locus-tag class description EQK04_00025 ENOG4105CDW Resistance protein EQK04_00030 ENOG4105CXN decarboxylase EQK04_00035 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EQK04_00040 ENOG4105X0R protein from nitrogen regulatory protein P-II EQK04_00045 ENOG4105XVJ Protein of unknown function (DUF327) EQK04_00050 ENOG4105FA2 dna polymerase iii EQK04_00055 ENOG4105MA4 psp1 domain protein EQK04_00060 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) EQK04_00065 ENOG41060K3 Methyltransferase EQK04_00070 ENOG4105VC4 domain protein EQK04_00075 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EQK04_00080 ENOG4105KRN Transcriptional regulator, abrb family EQK04_00090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EQK04_00095 ENOG4105F8V Hydrolase, tatD family EQK04_00100 ENOG41069ER domain protein EQK04_00110 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EQK04_00115 ENOG4105XFA sporulation peptidase YabG EQK04_00120 ENOG4105W42 Veg protein EQK04_00125 ENOG4105XEW small acid-soluble spore protein EQK04_00130 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EQK04_00135 ENOG4105DFT pur operon repressor EQK04_00140 ENOG4105KME endoribonuclease L-psp EQK04_00150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EQK04_00155 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EQK04_00160 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EQK04_00165 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EQK04_00175 ENOG4108JA2 transcriptioN-repair coupling factor EQK04_00180 ENOG4108M14 stage v sporulation protein t EQK04_00190 ENOG4108IY2 MazG family EQK04_00195 ENOG41082I2 s4 domain protein EQK04_00200 ENOG4105VYY sporulation protein yabp EQK04_00215 ENOG41060GV RNA binding s1 domain protein EQK04_00245 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EQK04_00250 ENOG4108UGV hypoxanthine phosphoribosyltransferase EQK04_00255 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EQK04_00260 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EQK04_00265 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EQK04_00270 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EQK04_00275 ENOG4105C6T cysteine synthase EQK04_00280 ENOG4105CRQ synthase (Component I) EQK04_00285 ENOG4105DDQ anthranilate synthase EQK04_00290 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EQK04_00295 ENOG4105EEI dihydropteroate synthase EQK04_00300 ENOG4105KRF dihydroneopterin aldolase EQK04_00305 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EQK04_00315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EQK04_00320 ENOG4105CRK lysyL-tRNA synthetase EQK04_00405 ENOG4108Z0C Uvrb UvrC protein EQK04_00410 ENOG41066A3 ATP guanido phosphotransferase EQK04_00420 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EQK04_00425 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EQK04_00430 ENOG4105CTP PilT protein domain protein EQK04_00435 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EQK04_00440 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EQK04_00445 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EQK04_00450 ENOG4105D7W serine acetyltransferase EQK04_00455 ENOG4105C8N cysteinyl-tRNA synthetase EQK04_00460 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EQK04_00465 ENOG4105C2N RNA methyltransferase TrmH family group 3 EQK04_00470 ENOG4105M0M Tetracycline resistance protein EQK04_00490 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EQK04_00500 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EQK04_00505 ENOG4108VZM 50s ribosomal protein L10 EQK04_00510 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EQK04_00515 ENOG4107Y49 methyltransferase EQK04_00520 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQK04_00525 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQK04_00530 ENOG4105XPM ribosomal protein EQK04_00535 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EQK04_00540 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EQK04_00545 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EQK04_00555 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EQK04_00560 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EQK04_00565 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EQK04_00570 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EQK04_00575 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EQK04_00580 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EQK04_00585 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EQK04_00590 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EQK04_00595 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EQK04_00600 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EQK04_00605 ENOG41082SA 50s ribosomal protein l29 EQK04_00610 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EQK04_00615 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EQK04_00620 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EQK04_00625 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EQK04_00630 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQK04_00635 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EQK04_00640 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EQK04_00645 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EQK04_00650 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EQK04_00655 ENOG4105VPB 50S ribosomal protein L30 EQK04_00660 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EQK04_00665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EQK04_00670 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EQK04_00675 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EQK04_00685 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EQK04_00690 ENOG41067V7 50S ribosomal protein L36 EQK04_00695 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EQK04_00700 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EQK04_00705 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EQK04_00710 ENOG4108ZT0 50S ribosomal protein l17 EQK04_00715 ENOG4108JJB ABC transporter EQK04_00720 ENOG4108JJB ABC transporter EQK04_00725 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQK04_00730 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EQK04_00735 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EQK04_00740 ENOG4108UJD 30S ribosomal protein S9 EQK04_00770 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQK04_00795 ENOG4105D1F ATP-binding protein EQK04_00810 ENOG4108NMV polysaccharide deacetylase EQK04_00840 ENOG4105I03 Flagellin EQK04_00845 ENOG4105CHH sulfate transporter EQK04_00855 ENOG4105EHZ conserved protein UCP016719 EQK04_00860 ENOG4105D17 glycoside hydrolase, family 3 domain protein EQK04_00880 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EQK04_00915 ENOG4105EMN RNA polymerase sigma factor EQK04_00925 ENOG4105C8B TIGR00159 family EQK04_00930 ENOG4107U5W ybbr family EQK04_00935 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EQK04_00940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EQK04_00960 ENOG4105DA5 (ABC) transporter EQK04_00970 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EQK04_00975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EQK04_00980 ENOG4105U3E Transcriptional regulator EQK04_00995 ENOG4107ZBH radical SAM domain protein EQK04_01000 ENOG41066N6 Abortive infection protein EQK04_01005 ENOG4108WUZ (ABC) transporter EQK04_01050 ENOG4105VZ8 Transcriptional regulator EQK04_01060 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EQK04_01080 ENOG4105CJ1 ABC, transporter EQK04_01100 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EQK04_01105 ENOG4105CXY transporter EQK04_01115 ENOG4105C7Z Conserved Protein EQK04_01120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQK04_01135 ENOG4105WAB arsR family transcriptional regulator EQK04_01150 ENOG4105XTG Pfam:DUF156 EQK04_01155 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EQK04_01165 ENOG4105VFE sira family EQK04_01170 ENOG4107TPS domain protein EQK04_01175 ENOG4105VFE sira family EQK04_01180 ENOG41087NI Sulfite exporter TauE/SafE EQK04_01190 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) EQK04_01195 ENOG4108SUT Major Facilitator Superfamily EQK04_01220 ENOG4105EWC Purine nucleoside phosphorylase EQK04_01240 ENOG4107SCQ Iron-containing alcohol dehydrogenase EQK04_01245 ENOG4105C72 UPF0176 protein EQK04_01250 ENOG4107QTZ amino acid EQK04_01260 ENOG4105CID antiterminator EQK04_01265 ENOG4105C5Y PTS System EQK04_01270 ENOG4105CS2 ec 3.2.1.21 EQK04_01285 ENOG4105EMD TRANSCRIPTIONal EQK04_01290 ENOG4105EVU fructokinase EQK04_01295 ENOG4105C8I hydrolase, family 38 EQK04_01300 ENOG4105DM4 PTS System EQK04_01305 ENOG4108YRF PTS System EQK04_01315 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_01330 ENOG4108IQI permease EQK04_01335 ENOG4108J5H Homocysteine s-methyltransferase EQK04_01340 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EQK04_01365 ENOG4105C2C drug resistance transporter, Bcr CflA EQK04_01370 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQK04_01385 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_01395 ENOG4105J7D transcriptional regulator EQK04_01405 ENOG41067TZ transcriptional regulator, MarR family EQK04_01415 ENOG4105CUB amino acid EQK04_01425 ENOG4105D74 hydrolase EQK04_01435 ENOG4105CSV Glutaminase EQK04_01450 ENOG41060AI SEC-C motif EQK04_01460 ENOG4107SET aldo keto reductase EQK04_01470 ENOG4107Y7X LytTR EQK04_01475 ENOG4108IUW ABC transporter EQK04_01480 ENOG4108SDH ABC, transporter EQK04_01505 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQK04_01515 ENOG4105DEN Luciferase family EQK04_01520 ENOG4108N0M stress protein EQK04_01525 ENOG4106FN3 tellurium resistance protein EQK04_01530 ENOG4106FN3 tellurium resistance protein EQK04_01535 ENOG4107TS3 membrane protein, TerC EQK04_01560 ENOG4108TTB tellurium resistance protein EQK04_01570 ENOG4108IJ7 Glycine betaine EQK04_01575 ENOG4107SQ8 Glycine betaine EQK04_01605 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQK04_01625 ENOG4105TRI Hydrolase EQK04_01665 ENOG4105EIG urea carboxylase-associated protein 1 EQK04_01670 ENOG4107RMH nh(3)-dependent nad( ) synthetase EQK04_01685 ENOG4105FF2 Type I DHQase EQK04_01690 ENOG4105C7K acetolactate synthase EQK04_01700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EQK04_01705 ENOG4105DJB Major Facilitator Superfamily EQK04_01720 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EQK04_01725 ENOG41089UC methyltransferase, type 11 EQK04_01730 ENOG4105C5Q Transcriptional regulator EQK04_01735 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQK04_01740 ENOG4105I82 acetyl xylan esterase EQK04_01750 ENOG410756H nucleotidyltransferase EQK04_01760 ENOG4105C26 Dehydrogenase EQK04_01765 ENOG4107YHD transcriptional regulator EQK04_01770 ENOG4107R5R arsenical pump membrane protein EQK04_01775 ENOG4105E5Q amino acid AbC transporter EQK04_01780 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EQK04_01790 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EQK04_01800 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EQK04_01810 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_01840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EQK04_01845 ENOG4105F38 ABC transporter, permease EQK04_01855 ENOG4105CEY Amp-dependent synthetase and ligase EQK04_01885 ENOG4105SX7 Transporter EQK04_01900 ENOG41086D8 Transcriptional regulator EQK04_01915 ENOG4105CDA abc transporter atp-binding protein EQK04_01920 ENOG4105DRP amino acid AbC transporter EQK04_01935 ENOG4108IQI permease EQK04_01940 ENOG4105DUX Transporter EQK04_01960 ENOG4105EAB amino acid AbC transporter EQK04_01965 ENOG4108HW4 amino acid AbC transporter EQK04_01980 ENOG4108PGP mmge prpd family protein EQK04_01990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQK04_01995 ENOG4105BZU Histidine kinase EQK04_02005 ENOG4105CFH Aspartokinase EQK04_02015 ENOG4105R8C Transcriptional regulator EQK04_02025 ENOG4105YVS arsR family transcriptional regulator EQK04_02035 ENOG4105EGI Transcriptional regulator EQK04_02045 ENOG4108JPW Aminotransferase EQK04_02050 ENOG4107QTZ amino acid EQK04_02055 ENOG4105C26 Dehydrogenase EQK04_02060 ENOG4105DYS nad(p)h dehydrogenase (quinone) EQK04_02065 ENOG4105KTB nuclear export factor GLE1 EQK04_02070 ENOG4108T5E Copper resistance protein EQK04_02085 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EQK04_02090 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_02130 ENOG4105X3H Excalibur domain protein EQK04_02140 ENOG4105E7W lamb ycsf family protein EQK04_02145 ENOG4105C5A transporter EQK04_02150 ENOG4105CFM UPF0317 protein EQK04_02155 ENOG4105P4J Allophanate hydrolase, subunit 1 EQK04_02165 ENOG4107258 Transcriptional regulator EQK04_02170 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQK04_02175 ENOG4105XJB lipolytic protein G-D-S-L family EQK04_02185 ENOG4105ETD TRANSCRIPTIONal EQK04_02190 ENOG4105HMZ Methyltransferase EQK04_02195 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EQK04_02200 ENOG410606W general stress protein EQK04_02220 ENOG4105VCH membrane EQK04_02225 ENOG4105DRR Transcriptional regulator, GntR family EQK04_02230 ENOG4106AXJ AraC family transcriptional regulator EQK04_02235 ENOG410631K Membrane EQK04_02240 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQK04_02245 ENOG4105C9U ATP-dependent DNA helicase RecQ EQK04_02260 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EQK04_02265 ENOG4107R8N Glycosyl transferase, family 2 EQK04_02275 ENOG4105C0X amino acid EQK04_02320 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EQK04_02325 ENOG4107BMA Transglycosylase associated protein EQK04_02330 ENOG4105EU9 EQK04_02335 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EQK04_02340 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EQK04_02345 ENOG4108MRH transcriptional regulatory protein EQK04_02350 ENOG4107QJT sodium dicarboxylate symporter EQK04_02355 ENOG4106F5Q Membrane EQK04_02365 ENOG4105CJ1 ABC, transporter EQK04_02385 ENOG4105SZ6 Thioredoxin EQK04_02390 ENOG4105CPF Cell wall formation (By similarity) EQK04_02395 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EQK04_02410 ENOG4105C1J atp-dependent rna helicase EQK04_02415 ENOG410905X membrane-flanked domain protein EQK04_02420 ENOG4105CKV Membrane EQK04_02435 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EQK04_02440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EQK04_02450 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EQK04_02455 ENOG4107MMM Anti-sigma-factor antagonist EQK04_02460 ENOG4105FUA antagonist EQK04_02465 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EQK04_02470 ENOG4107SGM protein serine threonine phosphatase EQK04_02475 ENOG4105WN5 stage II sporulation protein EQK04_02480 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQK04_02490 ENOG41064BQ Phosphatase EQK04_02510 ENOG4107RUY (E1 component), alpha subunit EQK04_02520 ENOG4107QKR Dehydrogenase EQK04_02530 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EQK04_02575 ENOG4105VEQ Cold shock protein EQK04_02580 ENOG4105C5Y PTS System EQK04_02585 ENOG410901P UPF0249 protein EQK04_02590 ENOG4105CID antiterminator EQK04_02595 ENOG4105DQ4 alcohol dehydrogenase EQK04_02600 ENOG4105VUF Transcriptional regulator EQK04_02620 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQK04_02635 ENOG4107GJV short-chain dehydrogenase reductase EQK04_02645 ENOG4107RB3 L-asparaginase EQK04_02670 ENOG4105H93 Acyltransferase family EQK04_02675 ENOG4105EYF MMPL domain protein EQK04_02680 ENOG4105ENE Histidine kinase EQK04_02685 ENOG4108VB1 regulatoR EQK04_02715 ENOG4105VDT -acetyltransferase EQK04_02720 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EQK04_02730 ENOG4105ST3 Transcriptional regulator EQK04_02735 ENOG4105NAE bifunctional deaminase-reductase domain protein EQK04_02740 ENOG41090MY MarR family Transcriptional regulator EQK04_02745 ENOG4108TVJ Nitroreductase EQK04_02760 ENOG4108JCI Transcriptional regulator EQK04_02765 ENOG4108VP3 Lysine exporter protein (LysE YggA) EQK04_02770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EQK04_02795 ENOG4108UMN azlc family EQK04_02850 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EQK04_02855 ENOG4105K8N protein family UPF0079, ATPase EQK04_02860 ENOG41072GX Peptidase M22 Glycoprotease EQK04_02865 ENOG410801F ribosomal-protein-alanine acetyltransferase EQK04_02870 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQK04_02875 ENOG4105C5H ABC transporter EQK04_02880 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EQK04_02885 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EQK04_02890 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EQK04_02895 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EQK04_02910 ENOG4108TYN CAAX amino terminal protease family protein EQK04_02915 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EQK04_02920 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EQK04_02925 ENOG4108U05 Transcriptional regulator EQK04_02930 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EQK04_02940 ENOG4108VXD carboxy-peptidase EQK04_02980 ENOG4107STQ Multicopper oxidase EQK04_02985 ENOG4105C85 amino acid EQK04_02995 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EQK04_03010 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EQK04_03035 ENOG4108UIN ybak prolyl-trna synthetase associated region EQK04_03045 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EQK04_03055 ENOG4108DMH HTH_ARAC EQK04_03080 ENOG4105DY9 regulatoR EQK04_03085 ENOG4105KNA -acetyltransferase EQK04_03100 ENOG4105JVQ RNA Polymerase EQK04_03110 ENOG4108RWP Major Facilitator Superfamily protein EQK04_03115 ENOG4105GZI Transcriptional regulator EQK04_03120 ENOG4105C7N Xanthine uracil vitamin C permease EQK04_03135 ENOG4108U5N UPF0316 protein EQK04_03145 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EQK04_03150 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EQK04_03155 ENOG4105C83 adenylosuccinate lyase EQK04_03160 ENOG4105C8V SAICAR synthetase EQK04_03165 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EQK04_03175 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EQK04_03185 ENOG4105CXB phosphoribosylaminoimidazole synthetase EQK04_03190 ENOG4108V3E phosphoribosylglycinamide formyltransferase EQK04_03195 ENOG4105DC1 bifunctional purine biosynthesis protein purh EQK04_03200 ENOG4105C12 Phosphoribosylglycinamide synthetase EQK04_03220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQK04_03235 ENOG4107S4Y M20 DapE family protein YgeY EQK04_03250 ENOG4105KGF protein, YerC YecD EQK04_03260 ENOG4105CBC glutamate synthase EQK04_03275 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) EQK04_03280 ENOG4105C4R Atp-dependent dna helicase EQK04_03285 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EQK04_03295 ENOG4105CRN Aminoglycoside phosphotransferase EQK04_03300 ENOG4105KT7 mgtC SapB transporter EQK04_03305 ENOG4105CK7 Sodium proline symporter EQK04_03310 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQK04_03315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EQK04_03320 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EQK04_03325 ENOG4108IG5 Transcriptional regulator EQK04_03335 ENOG4105DU0 nucleoside hydrolase EQK04_03340 ENOG4105CBD Diacylglycerol kinase EQK04_03345 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQK04_03385 ENOG41062ES Transcriptional regulator EQK04_03390 ENOG4105C3M thioredoxin reductase EQK04_03405 ENOG4105F8D glycoside hydrolase family 4 EQK04_03410 ENOG4105HX0 Transcriptional regulator EQK04_03435 ENOG4108R1P EQK04_03445 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EQK04_03455 ENOG41090R9 glycosyltransferase EQK04_03460 ENOG4107R51 Glycosyl transferase, family 2 EQK04_03465 ENOG41090R9 glycosyltransferase EQK04_03470 ENOG4105EU0 Major facilitator Superfamily EQK04_03475 ENOG4107RVG penicillin-binding protein EQK04_03480 ENOG4105C8P )-transporter EQK04_03510 ENOG4105CUB amino acid EQK04_03515 ENOG4107TVC Glycosyl transferase, family 2 EQK04_03520 ENOG4105C5H ABC transporter EQK04_03525 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EQK04_03530 ENOG4107SWG transcriptional regulator MERR family EQK04_03535 ENOG4105DXB Major Facilitator superfamily EQK04_03540 ENOG4105C5H ABC transporter EQK04_03545 ENOG4105FDU atp-dependent rna helicase EQK04_03550 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EQK04_03570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EQK04_03575 ENOG4105E6M Sulphatase-modifying factor protein EQK04_03585 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EQK04_03600 ENOG4108MRH transcriptional regulatory protein EQK04_03620 ENOG4105PY6 Phenolic acid decarboxylase EQK04_03625 ENOG4105U3E Transcriptional regulator EQK04_03640 ENOG41084AG Acylphosphatase EQK04_03645 ENOG4108RPX mosc domain containing protein EQK04_03660 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EQK04_03670 ENOG4105NX3 Membrane EQK04_03690 ENOG4105DY8 decarboxylase EQK04_03705 ENOG4105C5Y PTS System EQK04_03710 ENOG4105CG3 alpha amylase, catalytic region EQK04_03715 ENOG4107414 GntR family transcriptional regulator EQK04_03725 ENOG4105CGH 5'-nucleotidase EQK04_03730 ENOG4107RKG DJ-1/PfpI family EQK04_03740 ENOG4105BZG amino acid carrier protein EQK04_03750 ENOG4105KJF protein tyrosine phosphatase EQK04_03760 ENOG4107U9T Pfam:Ribonuclease_BN EQK04_03765 ENOG4108Z9I -acetyltransferase EQK04_03770 ENOG4108ISG Major Facilitator EQK04_03780 ENOG4105UPD Calcium Proton EQK04_03795 ENOG4105CDY transcriptional regulatory protein EQK04_03805 ENOG4105D8X mechanosensitive ion channel EQK04_03830 ENOG4105D7N magnesium and cobalt transport protein CorA EQK04_03845 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EQK04_03865 ENOG4107TXC Transcriptional regulator EQK04_03870 ENOG4108RWP Major Facilitator Superfamily protein EQK04_03930 ENOG410839T multidrug resistance protein EQK04_03950 ENOG4107TDE lipolytic protein G-D-S-L family EQK04_03965 ENOG4108HUF Transporter EQK04_03970 ENOG4105BZ1 (ABC) transporter EQK04_03975 ENOG4105KK4 UPF0060 membrane protein EQK04_03980 ENOG4105K6V RNA polymerase EQK04_04000 ENOG4108YYS metal-dependent hydrolase (By similarity) EQK04_04010 ENOG410834F Transcriptional regulator EQK04_04035 ENOG4107Y03 Nitroreductase EQK04_04050 ENOG4105ECP epimerase EQK04_04055 ENOG4105KC9 Modulates RecA activity (By similarity) EQK04_04080 ENOG4105CKK Glycosyl transferase, family 2 EQK04_04085 ENOG4105EJV Membrane EQK04_04090 ENOG4105MSY salicylate hydroxylase EQK04_04105 ENOG4105F0F Oxalate decarboxylase EQK04_04115 ENOG4106DF4 Sigma-70, region 4 EQK04_04125 ENOG41067AE Membrane-bound metal-dependent hydrolase EQK04_04130 ENOG4105CEN a g-specific adenine glycosylase EQK04_04135 ENOG4106BXE EQK04_04140 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EQK04_04155 ENOG4105EVI UPF0374 protein EQK04_04160 ENOG4105BZ1 (ABC) transporter EQK04_04165 ENOG4105C3U ABC transporter EQK04_04170 ENOG4108JQ7 (ABC) transporter EQK04_04175 ENOG4105DEF Extracellular solute-binding protein, family 5 EQK04_04180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQK04_04185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQK04_04190 ENOG4107NBY Membrane EQK04_04195 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQK04_04200 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQK04_04205 ENOG4105G5W regulator Fur family EQK04_04350 ENOG4105E0M Sulfatase EQK04_04370 ENOG4105E2Y ABC, transporter EQK04_04375 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EQK04_04380 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EQK04_04395 ENOG4105CJ1 ABC, transporter EQK04_04430 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EQK04_04440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EQK04_04445 ENOG4105CYN Serine protein kinase EQK04_04450 ENOG4106AKX UPF0229 protein EQK04_04455 ENOG4105CW7 secretion protein, HlyD family EQK04_04460 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQK04_04465 ENOG4105CS1 NAD(P)H quinone oxidoreductase EQK04_04475 ENOG4105VEQ Cold shock protein EQK04_04485 ENOG4105BZU Histidine kinase EQK04_04515 ENOG4105BZU Histidine kinase EQK04_04530 ENOG4108YBP pseudouridine synthase EQK04_04540 ENOG4107YBY Hydrolase EQK04_04545 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EQK04_04565 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EQK04_04570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EQK04_04575 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EQK04_04585 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EQK04_04590 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EQK04_04600 ENOG4105BZU Histidine kinase EQK04_04605 ENOG4105WH1 Two component transcriptional regulator luxr family EQK04_04620 ENOG4105CH6 catalase EQK04_04625 ENOG4105KPV Transcriptional regulator EQK04_04630 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EQK04_04635 ENOG4105ED1 spovr family EQK04_04640 ENOG4105G6Z alkaline phosphatase EQK04_04650 ENOG4105CUB amino acid EQK04_04660 ENOG4105J37 EQK04_04665 ENOG4108AEY RNA polymerase sigma factor EQK04_04670 ENOG4105F6E Acyl-transferase EQK04_04675 ENOG4105C37 (CBS) domain EQK04_04685 ENOG4105C37 (CBS) domain EQK04_04695 ENOG4106A8V Protein CrcB homolog EQK04_04700 ENOG4105WMR Protein CrcB homolog EQK04_04705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQK04_04715 ENOG4105D64 Mechanosensitive ion channel EQK04_04720 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EQK04_04725 ENOG4107VMI polysaccharide deacetylase EQK04_04730 ENOG4105F0I Aminotransferase EQK04_04745 ENOG4105BZ1 (ABC) transporter EQK04_04750 ENOG4105BZ1 (ABC) transporter EQK04_04780 ENOG410839P EQK04_04790 ENOG4108UH6 UPF0754 membrane protein EQK04_04795 ENOG4105WZB UPF0342 protein EQK04_04805 ENOG4105D4P Coproporphyrinogen iii oxidase EQK04_04815 ENOG4107S91 Sodium hydrogen exchanger EQK04_04820 ENOG4105NCW Trka-c domain protein EQK04_04830 ENOG4105CGU Enoyl-CoA hydratase EQK04_04840 ENOG4107VRP DNA repair exonuclease EQK04_04845 ENOG4106D4I domain protein EQK04_04860 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EQK04_04905 ENOG4105NBU tryptophan transport protein EQK04_04910 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EQK04_04915 ENOG4105K59 histidine triad (HIT) protein EQK04_04950 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EQK04_04955 ENOG4105BZ4 penicillin-binding protein EQK04_04960 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EQK04_04965 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EQK04_04970 ENOG4105C1Q protoporphyrinogen oxidase EQK04_04980 ENOG4105ECB domain protein EQK04_04985 ENOG4105DER m42 family EQK04_04995 ENOG4106AXD EQK04_05000 ENOG4108RQ5 Beta-lactamase domain-containing protein EQK04_05005 ENOG4105DF9 Lipoate-protein, ligase EQK04_05010 ENOG4105CEY Amp-dependent synthetase and ligase EQK04_05020 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EQK04_05025 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_05030 ENOG4107TB6 phosphoglycerate mutase EQK04_05035 ENOG4106YBV Methyl-accepting chemotaxis EQK04_05055 ENOG4105XVF Competence transcription factor EQK04_05070 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQK04_05075 ENOG4105C0R drug resistance transporter emrb qaca subfamily EQK04_05080 ENOG41067XF inhibitor EQK04_05085 ENOG4105DHS permease protein EQK04_05090 ENOG4105CM4 permease protein EQK04_05095 ENOG4108IPW abc transporter atp-binding protein EQK04_05105 ENOG4108KGH TRANSCRIPTIONal EQK04_05120 ENOG41060YP EQK04_05140 ENOG4108KK1 membrane protein AbrB duplication EQK04_05170 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EQK04_05180 ENOG4105EYH Exonuclease EQK04_05240 ENOG4105ERH Fumarylacetoacetate hydrolase EQK04_05245 ENOG4106BKT UPF0344 protein EQK04_05255 ENOG4105CAQ asparagine synthetase EQK04_05275 ENOG4105UQX Mate efflux family protein EQK04_05280 ENOG4106HBX Transcriptional Regulator AraC Family EQK04_05305 ENOG4105DY8 decarboxylase EQK04_05350 ENOG4108VPT UPF0234 protein EQK04_05355 ENOG4105QNR S1 RNA binding domain protein EQK04_05360 ENOG4105DIH basic membrane EQK04_05365 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_05370 ENOG4105EPR degv family EQK04_05375 ENOG4107AYK membrAne EQK04_05385 ENOG41073B9 EQK04_05395 ENOG4108KP7 hydrolase EQK04_05400 ENOG4108MXZ Esterase EQK04_05405 ENOG4105VG1 fes assembly suf system protein EQK04_05410 ENOG4105IQ5 FAD linked oxidase domain protein EQK04_05420 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EQK04_05425 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EQK04_05430 ENOG4105CAS nag kinase EQK04_05435 ENOG4105C8Y Acetylornithine aminotransferase EQK04_05440 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQK04_05450 ENOG4105DBV ornithine carbamoyltransferase EQK04_05480 ENOG4107RMD Basic membrane lipoprotein EQK04_05495 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EQK04_05500 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EQK04_05510 ENOG4105C3U ABC transporter EQK04_05515 ENOG4108JQ7 (ABC) transporter EQK04_05530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQK04_05540 ENOG4105C31 Tryptophanyl-tRNA synthetase EQK04_05545 ENOG4108J59 Extracellular solute-binding protein, family 5 EQK04_05550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQK04_05555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQK04_05565 ENOG4108JQ7 (ABC) transporter EQK04_05580 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EQK04_05585 ENOG4108ZCF integral membrane protein EQK04_05590 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EQK04_05595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQK04_05605 ENOG4105DPN Oligoendopeptidase f EQK04_05615 ENOG4105T58 Dithiol-disulfide isomerase EQK04_05620 ENOG4108Z18 K06886 hemoglobin EQK04_05625 ENOG4105E4C Lytic transglycosylase catalytic EQK04_05630 ENOG4105MIX Adenylate cyclase EQK04_05635 ENOG4106EFP UPF0738 protein EQK04_05645 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQK04_05650 ENOG4105EMS pseudouridine synthase EQK04_05655 ENOG4107S1Q Phosphatase EQK04_05665 ENOG4105ETU transcriptional activator (TenA EQK04_05670 ENOG4108VEU Thiamine monophosphate synthase EQK04_05685 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EQK04_05690 ENOG4105D06 uba thif-type nad fad binding protein EQK04_05695 ENOG4105DWF phosphomethylpyrimidine kinase EQK04_05700 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EQK04_05705 ENOG4107A88 EQK04_05755 ENOG4105ENA helicase EQK04_05780 ENOG4105C28 cystathionine EQK04_05785 ENOG4105C28 cystathionine EQK04_05795 ENOG41067QW Transcriptional regulator EQK04_05835 ENOG4105N14 lysine exporter protein LysE YggA EQK04_05905 ENOG4107V2S Transcriptional regulator EQK04_05910 ENOG4105DJ2 Major Facilitator Superfamily EQK04_05940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EQK04_05950 ENOG4105PF9 Transcriptional regulator EQK04_05960 ENOG4105I03 Flagellin EQK04_05965 ENOG4105I03 Flagellin EQK04_05970 ENOG4105I03 Flagellin EQK04_05975 ENOG4105I03 Flagellin EQK04_05995 ENOG4105K7W phage-related replication protein EQK04_06000 ENOG410635T phage-like element pbsx protein EQK04_06005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EQK04_06025 ENOG4105CJ3 phosphate transporter EQK04_06030 ENOG4107GRR phosphate transport regulator EQK04_06040 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EQK04_06045 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EQK04_06050 ENOG4108I5D sulfate abc transporter EQK04_06055 ENOG4105ECW sulfate abc transporter EQK04_06060 ENOG4108IJ6 ABC transporter EQK04_06070 ENOG4105DT3 PTS system, galactitol-specific IIc component EQK04_06090 ENOG4107RUY (E1 component), alpha subunit EQK04_06095 ENOG4105CPP Dehydrogenase, E1 component EQK04_06100 ENOG4107QKR Dehydrogenase EQK04_06110 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EQK04_06115 ENOG4105CHR reductase EQK04_06120 ENOG4107RHR regulatoR EQK04_06130 ENOG4107R7I amino acid EQK04_06145 ENOG4105C0H protease EQK04_06155 ENOG4108ME1 Peptidase M55 D-aminopeptidase EQK04_06160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQK04_06165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQK04_06170 ENOG4105C3U ABC transporter EQK04_06180 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQK04_06185 ENOG4105DTQ mandelate racemase muconate lactonizing EQK04_06190 ENOG4107SN7 NLP P60 protein EQK04_06195 ENOG4108JQ7 (ABC) transporter EQK04_06200 ENOG4107TUM Amidinotransferase EQK04_06205 ENOG4108S4H thioesterase Superfamily protein EQK04_06210 ENOG4105K7K Transcriptional regulator EQK04_06225 ENOG4108428 Inherit from COG: -acetyltransferase EQK04_06230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQK04_06235 ENOG410839T multidrug resistance protein EQK04_06240 ENOG41080TC multidrug resistance protein EQK04_06250 ENOG4105CIY formyltetrahydrofolate deformylase EQK04_06255 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQK04_06260 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQK04_06280 ENOG4105K56 Transcriptional regulator EQK04_06285 ENOG4108ZHJ Organic hydroperoxide resistance protein EQK04_06290 ENOG4107Y2X deaminase EQK04_06295 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EQK04_06300 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_06315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQK04_06320 ENOG41062D9 Histidine kinase EQK04_06330 ENOG4106849 propeptide, pepSY amd peptidase M4 EQK04_06340 ENOG4105CJW magnesium transporter EQK04_06360 ENOG4105V75 Transcriptional regulator EQK04_06375 ENOG4105BZU Histidine kinase EQK04_06380 ENOG4107T5V SNARE associated Golgi EQK04_06385 ENOG4107TS3 membrane protein, TerC EQK04_06390 ENOG4108WZW RNA polymerase sigma EQK04_06400 ENOG410681C small acid-soluble spore protein EQK04_06410 ENOG4105D0M Protease HtpX homolog EQK04_06420 ENOG410900G Protein of unknown function (DUF421) EQK04_06430 ENOG4108TGC Acyltransferase EQK04_06435 ENOG4105BZU Histidine kinase EQK04_06440 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EQK04_06445 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EQK04_06450 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EQK04_06460 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EQK04_06465 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EQK04_06470 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EQK04_06475 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EQK04_06485 ENOG4105BZU Histidine kinase EQK04_06490 ENOG41090MY MarR family Transcriptional regulator EQK04_06495 ENOG4105ER2 Ompa motb domain protein EQK04_06500 ENOG4105E14 MotA TolQ exbB proton channel EQK04_06510 ENOG4108K88 Membrane EQK04_06515 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EQK04_06520 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EQK04_06525 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EQK04_06530 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EQK04_06555 ENOG4105F0V Cell wall hydrolase EQK04_06570 ENOG4105C59 p-type ATPase EQK04_06575 ENOG4105DC7 peptidase M24 EQK04_06585 ENOG4105CID antiterminator EQK04_06595 ENOG4105KRI phosphocarrier protein (HPr EQK04_06600 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EQK04_06610 ENOG4105F6S Spore photoproduct lyase EQK04_06615 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EQK04_06620 ENOG4105CHR reductase EQK04_06625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQK04_06630 ENOG4105K4I Scp-like extracellular EQK04_06640 ENOG4105BZU Histidine kinase EQK04_06645 ENOG4105CHM Aminotransferase EQK04_06655 ENOG41085PJ rdd domain containing protein EQK04_06665 ENOG4107R88 Chemotaxis protein (CheV) EQK04_06670 ENOG4105UIN EQK04_06675 ENOG4108MCI Transcriptional regulator, ARAC family EQK04_06680 ENOG4108UZ3 Transporter EQK04_06700 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein EQK04_06710 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EQK04_06715 ENOG4105EPM Diguanylate phosphodiesterase EQK04_06720 ENOG4105WEF catalase EQK04_06725 ENOG4107IN1 Protein of unknown function (DUF1797) EQK04_06730 ENOG4108XRC Protein of unknown function (DUF458) EQK04_06765 ENOG4105NQC Flavodoxin EQK04_06770 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EQK04_06780 ENOG4106AUC UPF0180 protein EQK04_06785 ENOG4105D8X mechanosensitive ion channel EQK04_06790 ENOG4105D3R alkyl hydroperoxide reductase EQK04_06795 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQK04_06810 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EQK04_06815 ENOG4105D06 uba thif-type nad fad binding protein EQK04_06820 ENOG4105CVM Molybdenum cofactor synthesis domain protein EQK04_06825 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EQK04_06830 ENOG4108ZAF Molybdopterin EQK04_06835 ENOG41067WU Molybdopterin converting factor (Subunit 1) EQK04_06850 ENOG4107X8C Efflux transporter RND family MFP subunit EQK04_06855 ENOG4105C19 ABC transporter EQK04_06860 ENOG4107RBB ABC transporter, permease EQK04_06865 ENOG4105E98 transcriptional regulator DeoR family EQK04_06870 ENOG4105DE4 1-phosphofructokinase EQK04_06875 ENOG4105DM4 PTS System EQK04_06890 ENOG4105C5H ABC transporter EQK04_06920 ENOG4105BZU Histidine kinase EQK04_06930 ENOG4107ZYR domain protein EQK04_06935 ENOG4105CPN adenine deaminase EQK04_06940 ENOG4105CN5 Metallo-Beta-Lactamase EQK04_06950 ENOG4108X4Q Hydrolase EQK04_06955 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQK04_06975 ENOG4105CPP Dehydrogenase, E1 component EQK04_06980 ENOG4105C7S Dehydrogenase EQK04_06985 ENOG4107QN2 dihydrolipoyl dehydrogenase EQK04_07000 ENOG4105CXN decarboxylase EQK04_07010 ENOG4108WQ8 UPF0637 protein EQK04_07020 ENOG4105ECY inositol monophosphatase EQK04_07055 ENOG4105CI3 gtp-binding protein typa EQK04_07060 ENOG4105QA2 EQK04_07075 ENOG4108IAB Phoh family EQK04_07085 ENOG4105CSV Glutaminase EQK04_07095 ENOG4105CNI cell division protein FtsW EQK04_07100 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EQK04_07105 ENOG4105CVP deoxyribo-dipyrimidine photolyase EQK04_07115 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EQK04_07125 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQK04_07130 ENOG4105CCU oxidase (Subunit III) EQK04_07135 ENOG41064X9 cytochrome C oxidase subunit IV EQK04_07150 ENOG41080XQ Signal transduction protein with cbs domains EQK04_07155 ENOG4106UY4 Inherit from COG: Scp-like extracellular EQK04_07180 ENOG4105WUC UPF0298 protein EQK04_07185 ENOG4106H78 methyltransferase EQK04_07190 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EQK04_07195 ENOG4105H20 Sporulation integral membrane protein YlbJ EQK04_07200 ENOG4105D78 K07001 NTE family protein EQK04_07205 ENOG41063PX domain protein EQK04_07210 ENOG4105CDE UPF0348 protein EQK04_07215 ENOG4105KNH Nucleic acid-binding protein EQK04_07220 ENOG41067VY 50S ribosomal protein L32 EQK04_07245 ENOG4108V6E Cell division protein mraZ EQK04_07250 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EQK04_07260 ENOG4105CJN penicillin-binding protein EQK04_07270 ENOG4105CJN penicillin-binding protein EQK04_07275 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EQK04_07280 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EQK04_07285 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EQK04_07290 ENOG4105CNI cell division protein FtsW EQK04_07295 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EQK04_07300 ENOG4105D4A Cell wall formation (By similarity) EQK04_07305 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EQK04_07310 ENOG4108R2U division initiation protein EQK04_07320 ENOG4105K67 small basic protein EQK04_07325 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EQK04_07330 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EQK04_07340 ENOG4105FFI sigma-e processing peptidase spoiiga EQK04_07345 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_07355 ENOG4105DKT Transcriptional regulator EQK04_07370 ENOG410787A Pts system, glucitol sorbitol-specific EQK04_07375 ENOG4105DZY Pts system, glucitol sorbitol-specific EQK04_07380 ENOG4105VI0 Pts system, glucitol sorbitol-specific EQK04_07385 ENOG4105DKW ABC transporter EQK04_07390 ENOG4105WR5 sporulation protein, YlmC YmxH family EQK04_07395 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EQK04_07400 ENOG4105DFA alanine racemase domain protein EQK04_07405 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EQK04_07410 ENOG41067XK integral membrane protein EQK04_07415 ENOG4105DBK s4 domain protein EQK04_07425 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EQK04_07435 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EQK04_07440 ENOG4105C34 Pseudouridine synthase EQK04_07445 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EQK04_07455 ENOG4105CXT aspartate transcarbamylase EQK04_07460 ENOG4105CD3 dihydroorotase EQK04_07465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EQK04_07470 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EQK04_07475 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EQK04_07480 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) EQK04_07485 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EQK04_07490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EQK04_07500 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EQK04_07510 ENOG4107RIQ Sulfate adenylate transferase EQK04_07515 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) EQK04_07520 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EQK04_07525 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EQK04_07530 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EQK04_07545 ENOG4105DSJ YicC domain protein EQK04_07550 ENOG4105KC4 UPF0296 protein EQK04_07555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EQK04_07565 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EQK04_07570 ENOG4105C25 Primosomal protein n' EQK04_07575 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EQK04_07580 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EQK04_07585 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EQK04_07590 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EQK04_07595 ENOG4108ZF3 Phosphatase EQK04_07600 ENOG4105D9P serine threonine protein kinase EQK04_07605 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EQK04_07610 ENOG4105DJV ribulose-phosphate 3-epimerase EQK04_07615 ENOG4105FJ0 thiamine EQK04_07625 ENOG4105VB9 50S ribosomal protein l28 EQK04_07630 ENOG4108ZAA Alkaline-shock protein EQK04_07635 ENOG4105DP4 dak2 domain fusion protein ylov EQK04_07645 ENOG4105EJQ L-serine dehydratase EQK04_07650 ENOG4105CB5 ATP-dependent DNA helicase recG EQK04_07655 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EQK04_07660 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EQK04_07665 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EQK04_07670 ENOG4105CHR reductase EQK04_07675 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EQK04_07680 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EQK04_07685 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EQK04_07690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EQK04_07695 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EQK04_07705 ENOG4105K5M 30s ribosomal protein S16 EQK04_07710 ENOG4108BW8 UPF0109 protein EQK04_07720 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EQK04_07725 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EQK04_07730 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EQK04_07735 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EQK04_07740 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQK04_07750 ENOG4105VM1 flagellar EQK04_07755 ENOG4105CMV Succinyl-CoA synthetase subunit beta EQK04_07760 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EQK04_07765 ENOG4105C79 DNA protecting protein DprA EQK04_07770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EQK04_07775 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EQK04_07780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQK04_07785 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EQK04_07790 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EQK04_07800 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EQK04_07805 ENOG4108ZC9 flagellar basal-body rod protein flgc EQK04_07810 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EQK04_07815 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EQK04_07820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQK04_07835 ENOG4106YF4 Flagellar biosynthesis chaperone EQK04_07845 ENOG410696Y Flagellar hook-length control protein EQK04_07850 ENOG410822I Flagellar hook capping protein EQK04_07855 ENOG4108JQA flagellar EQK04_07860 ENOG41068WV flagellar FlbD family protein EQK04_07870 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EQK04_07875 ENOG4105DD5 Flagellar motor switch protein EQK04_07880 ENOG4107YTP response regulator receiver protein EQK04_07890 ENOG4105CN7 Flagellar biosynthetic protein FliP EQK04_07895 ENOG4105VS8 Flagellar biosynthetic protein fliq EQK04_07900 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EQK04_07905 ENOG4105D00 flagellar biosynthetic protein flhB EQK04_07910 ENOG4105D7B Flagellar biosynthesis protein flha EQK04_07915 ENOG4105FZW flagellar biosynthesis regulator FlhF EQK04_07925 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EQK04_07930 ENOG4105CBS Chea signal transduction histidine kinase EQK04_07935 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EQK04_07945 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EQK04_07950 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_07960 ENOG4105CE9 30S ribosomal protein S2 EQK04_07965 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EQK04_07975 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EQK04_07980 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EQK04_07985 ENOG4105KNE Phosphatidate cytidylyltransferase EQK04_07990 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EQK04_07995 ENOG4105DZP Membrane-associated zinc metalloprotease EQK04_08000 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EQK04_08005 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EQK04_08015 ENOG4105CYP glycoside hydrolase, family EQK04_08035 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EQK04_08040 ENOG4105CHV Transcription elongation factor NusA EQK04_08045 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EQK04_08050 ENOG4105VHM ribosomal protein EQK04_08055 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EQK04_08060 ENOG4105W7A Protein of unknown function (DUF503) EQK04_08065 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EQK04_08070 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EQK04_08075 ENOG4105DTN riboflavin biosynthesis protein ribF EQK04_08080 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EQK04_08085 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EQK04_08095 ENOG4105C1V Peptidase, M16 EQK04_08110 ENOG4105E35 Dipicolinate synthase subunit A EQK04_08115 ENOG4108S0H Dipicolinic acid synthetase, b subunit EQK04_08120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EQK04_08130 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQK04_08140 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EQK04_08150 ENOG4105CNU cell division protein FtsK EQK04_08155 ENOG4105FDP GntR family transcriptional regulator EQK04_08165 ENOG4105EYF MMPL domain protein EQK04_08185 ENOG4105EYF MMPL domain protein EQK04_08190 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EQK04_08195 ENOG4105XZV Protein of unknown function (DUF3243) EQK04_08210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EQK04_08215 ENOG4105CEV competence damage-inducible protein EQK04_08220 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EQK04_08225 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) EQK04_08230 ENOG4105D48 metallophosphoesterase EQK04_08235 ENOG4105MCT stage V sporulation protein S EQK04_08245 ENOG4105CPQ Dehydrogenase EQK04_08250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EQK04_08255 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQK04_08270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EQK04_08275 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EQK04_08295 ENOG4108VJ1 Transcriptional regulator (CarD family EQK04_08300 ENOG4105K7W phage-related replication protein EQK04_08310 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_08315 ENOG4105K7W phage-related replication protein EQK04_08320 ENOG4108X3M OsmC Ohr family protein EQK04_08350 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EQK04_08370 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EQK04_08375 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQK04_08380 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EQK04_08385 ENOG4105U6W MutT NUDIX family protein EQK04_08395 ENOG4106F1P AAA ATPase, central domain protein EQK04_08400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EQK04_08405 ENOG4105CXI aluminum resistance protein EQK04_08410 ENOG4105KV4 Transcriptional regulator EQK04_08415 ENOG4105C5F glutamine synthetase EQK04_08480 ENOG4108ZMX Domain of unknown function (DU1801) EQK04_08500 ENOG410780I phosphoprotein phosphatase activity EQK04_08510 ENOG4105XPP Protein of unknown function (DUF1275) EQK04_08515 ENOG4105DQE DNA ligase EQK04_08520 ENOG4105FDF Could be involved in DNA repair (By similarity) EQK04_08525 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EQK04_08535 ENOG4108Z40 Transcriptional regulator EQK04_08540 ENOG4105ECR NmrA family EQK04_08550 ENOG4107R5T Cysteine-rich domain EQK04_08555 ENOG4107QR9 Iron-sulfur cluster binding protein EQK04_08560 ENOG41080R8 Conserved Protein EQK04_08575 ENOG4108QY0 Membrane EQK04_08580 ENOG41082JN Transcriptional regulator EQK04_08585 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQK04_08590 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases EQK04_08595 ENOG4105EDW glycosyl transferase, family 39 EQK04_08600 ENOG4105WFK nuclease EQK04_08605 ENOG4106SCS STAS domain EQK04_08620 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EQK04_08630 ENOG4108SVB resolvase EQK04_08635 ENOG4105VPS UPF0291 protein EQK04_08640 ENOG4105CV1 Transketolase (EC 2.2.1.1) EQK04_08650 ENOG4105VXM UPF0154 protein EQK04_08660 ENOG4107QIV Cytochrome c biogenesis protein EQK04_08690 ENOG4108I0Z Aconitate hydratase EQK04_08695 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQK04_08720 ENOG4105MI2 EQK04_08725 ENOG4105W8X HesB YadR YfhF-family protein EQK04_08730 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EQK04_08735 ENOG4105K4P CoA-binding domain protein EQK04_08740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQK04_08755 ENOG4106UW1 Major Facilitator superfamily EQK04_08760 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQK04_08770 ENOG4108UXE Protein tyrosine phosphatase EQK04_08775 ENOG4107R5R arsenical pump membrane protein EQK04_08780 ENOG41082YX Transcriptional regulator, arsr family EQK04_08790 ENOG4107ZXU DSBA oxidoreductase EQK04_08805 ENOG4105ST3 Transcriptional regulator EQK04_08810 ENOG4105DYS nad(p)h dehydrogenase (quinone) EQK04_08815 ENOG4105KVH Transcriptional regulator EQK04_08820 ENOG4105C6T cysteine synthase EQK04_08825 ENOG4105KME endoribonuclease L-psp EQK04_08840 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) EQK04_08870 ENOG4108Z6Z Transcriptional regulator EQK04_08875 ENOG4105CS2 ec 3.2.1.21 EQK04_08880 ENOG4105C5Y PTS System EQK04_08900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQK04_08910 ENOG4107SYN Glycosyl hydrolases family 43 EQK04_08945 ENOG4105UP7 3-epimerase EQK04_08960 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EQK04_09015 ENOG4105DM4 PTS System EQK04_09020 ENOG4105DM4 PTS System EQK04_09025 ENOG4105DE4 1-phosphofructokinase EQK04_09030 ENOG4105HX0 Transcriptional regulator EQK04_09035 ENOG4107RZC phospholipase d EQK04_09055 ENOG4105C26 Dehydrogenase EQK04_09060 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EQK04_09070 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQK04_09075 ENOG4107QX3 carboxylase EQK04_09080 ENOG4105E39 Enoyl-CoA hydratase EQK04_09085 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EQK04_09090 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EQK04_09095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQK04_09100 ENOG4105CEY Amp-dependent synthetase and ligase EQK04_09105 ENOG4105C1G acyl-Coa dehydrogenase EQK04_09110 ENOG4105F32 YngK protein EQK04_09120 ENOG4105E98 transcriptional regulator DeoR family EQK04_09125 ENOG41090U3 tautomerase EQK04_09140 ENOG4105CQB FAD linked oxidase domain protein EQK04_09145 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EQK04_09155 ENOG4108B31 Spore germination protein EQK04_09175 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQK04_09180 ENOG4107T5V SNARE associated Golgi EQK04_09185 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EQK04_09195 ENOG4105DEN Luciferase family EQK04_09210 ENOG4107QJQ Mate efflux family protein EQK04_09215 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EQK04_09220 ENOG4105NBR Pectinesterase EQK04_09225 ENOG4105H67 Protein of unknown function (DUF421) EQK04_09230 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EQK04_09235 ENOG4108IFG nitrite reductase, (NAD(P)H) EQK04_09240 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EQK04_09255 ENOG4105BZ8 glutamate synthase EQK04_09260 ENOG4105CBC glutamate synthase EQK04_09265 ENOG4105C5Q Transcriptional regulator EQK04_09275 ENOG4105BZ1 (ABC) transporter EQK04_09280 ENOG41090E6 transcriptional regulator MERR family EQK04_09285 ENOG4108UYN gCN5-related N-acetyltransferase EQK04_09290 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EQK04_09295 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EQK04_09300 ENOG4105II7 pyrroline-5-carboxylate reductase EQK04_09310 ENOG4108J2R molybdopterin oxidoreductase EQK04_09320 ENOG4105CMG Carbohydrate kinase EQK04_09330 ENOG4105E2R ROK family EQK04_09340 ENOG4105CT4 transporter EQK04_09345 ENOG4108Z7R Chaperone CsaA EQK04_09355 ENOG4105FVX EQK04_09375 ENOG4108W8B Beta-lactamase domain protein EQK04_09385 ENOG4105D29 Helix-turn-helix type 11 domain protein EQK04_09395 ENOG4105KTU Transcriptional regulator, arsr family EQK04_09400 ENOG4105CUB amino acid EQK04_09410 ENOG4105CR4 methylisocitrate lyase EQK04_09415 ENOG4105DXD 2-methylcitrate dehydratase EQK04_09425 ENOG4108SJC Membrane EQK04_09435 ENOG41069ER domain protein EQK04_09440 ENOG4105C9U ATP-dependent DNA helicase RecQ EQK04_09450 ENOG4105SCY DNAK suppressor EQK04_09475 ENOG4105C26 Dehydrogenase EQK04_09480 ENOG4105EWU Squalene--hopene cyclase EQK04_09485 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQK04_09490 ENOG4105C09 Bile acid EQK04_09495 ENOG4105C7S Dehydrogenase EQK04_09500 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EQK04_09505 ENOG4107T89 von Willebrand factor, type A EQK04_09510 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EQK04_09520 ENOG4105K4H Nlp p60 protein EQK04_09530 ENOG4107QMU Mate efflux family protein EQK04_09550 ENOG4105FR1 rard protein EQK04_09580 ENOG4105E1V na solute symporter EQK04_09605 ENOG4108VXD carboxy-peptidase EQK04_09610 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EQK04_09615 ENOG4106Z5R EQK04_09620 ENOG410841Q phosphoesterase PA-phosphatase related protein EQK04_09635 ENOG4105VSD UPF0346 protein EQK04_09645 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EQK04_09650 ENOG4108JUB Transcriptional regulator EQK04_09680 ENOG4105C5E polysaccharide biosynthesis protein EQK04_09685 ENOG4105E0X reductase EQK04_09690 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EQK04_09720 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EQK04_09725 ENOG41090WU lipolytic protein G-D-S-L family EQK04_09730 ENOG4108KF3 Electron transport protein SCO1 SenC EQK04_09735 ENOG4108RCR degv family EQK04_09745 ENOG4105C7B Threonine dehydratase EQK04_09755 ENOG4108UT2 hemolysin iii EQK04_09765 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EQK04_09770 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EQK04_09785 ENOG4107YX5 Pfam:DUF548 EQK04_09790 ENOG4108Y6J UPF0403 protein EQK04_09795 ENOG4105C01 Dihydroxy-acid dehydratase EQK04_09810 ENOG4108V06 Glutathione peroxidase EQK04_09815 ENOG4105CKU formyltetrahydrofolate synthetase EQK04_09820 ENOG4105CVG Homoserine O-transsuccinylase EQK04_09825 ENOG4108QBV Monogalactosyldiacylglycerol synthase EQK04_09860 ENOG41081VK Ribonuclease EQK04_09880 ENOG410890F Dynamin family EQK04_09895 ENOG41065KQ synthase EQK04_09900 ENOG4105RHY Pfam:UPF0157 EQK04_09905 ENOG4107VMI polysaccharide deacetylase EQK04_09910 ENOG4105C2W permease EQK04_09920 ENOG4105CTD carboxy-peptidase EQK04_09925 ENOG4105DVT helicase EQK04_09935 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EQK04_09945 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) EQK04_09950 ENOG4108UKS UPF0398 protein EQK04_09960 ENOG4107X2U Inherit from COG: Exonuclease-like protein EQK04_09965 ENOG4108I5C dEAD DEAH box helicase EQK04_09970 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQK04_10010 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) EQK04_10015 ENOG4105BZ4 penicillin-binding protein EQK04_10025 ENOG4105CSM endonuclease III EQK04_10045 ENOG4105YAC EQK04_10050 ENOG4105DVT helicase EQK04_10055 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EQK04_10060 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EQK04_10065 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EQK04_10075 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EQK04_10080 ENOG4105CPK Glycosyl transferase (Group 1 EQK04_10085 ENOG4105FJR Lmbe family EQK04_10090 ENOG4108Z5K methylglyoxal synthase EQK04_10095 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EQK04_10100 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EQK04_10105 ENOG4108JYZ YitT family EQK04_10125 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EQK04_10140 ENOG4108SXZ UPF0302 protein EQK04_10145 ENOG41068YB TPR repeat-containing protein EQK04_10150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EQK04_10160 ENOG4105CIH Imidazole acetol-phosphate transaminase EQK04_10165 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EQK04_10170 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EQK04_10175 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EQK04_10180 ENOG4105DK0 Indole-3-glycerol phosphate synthase EQK04_10185 ENOG4108I0Q anthranilate phosphoribosyltransferase EQK04_10195 ENOG4105KHN chorismate mutase EQK04_10200 ENOG4105D49 3-dehydroquinate synthase EQK04_10205 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EQK04_10210 ENOG4105BZU Histidine kinase EQK04_10215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EQK04_10220 ENOG4105EAH synthase EQK04_10225 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EQK04_10230 ENOG4105XXQ heptaprenyl diphosphate synthase component I EQK04_10240 ENOG4105EUJ GTP cyclohydrolase i EQK04_10245 ENOG4105K70 DNA-binding protein EQK04_10250 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EQK04_10265 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EQK04_10270 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EQK04_10275 ENOG41065D1 EQK04_10280 ENOG4105S2F EQK04_10305 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EQK04_10310 ENOG4105CAT Cytidine monophosphate kinase EQK04_10325 ENOG4105MSI germination protein ypeb EQK04_10335 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) EQK04_10340 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EQK04_10355 ENOG4107RGJ metallophosphoesterase EQK04_10370 ENOG4105I7S Abortive infection protein EQK04_10375 ENOG4105C9U ATP-dependent DNA helicase RecQ EQK04_10380 ENOG4105T7X EQK04_10390 ENOG4108SAX Membrane EQK04_10395 ENOG4108JQ1 Dehydrogenase EQK04_10415 ENOG4105BZU Histidine kinase EQK04_10420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQK04_10425 ENOG4105CRE cytochrome C EQK04_10430 ENOG4107TWT Cytochrome c biogenesis protein EQK04_10440 ENOG4105FE9 pseudouridine synthase EQK04_10450 ENOG4108JIC nucleoside recognition domain protein EQK04_10455 ENOG4105DZ1 carboxypeptidase EQK04_10465 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EQK04_10470 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EQK04_10495 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EQK04_10500 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EQK04_10505 ENOG4108R6K riboflavin synthase, subunit alpha EQK04_10535 ENOG4107ZE5 PPIases accelerate the folding of proteins EQK04_10540 ENOG4105PTM secreted protein EQK04_10545 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EQK04_10555 ENOG4105G6R Stage v sporulation protein ae EQK04_10565 ENOG4105CZ3 stage V sporulation protein ad EQK04_10570 ENOG41090VF Stage v sporulation protein ac EQK04_10585 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_10590 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EQK04_10595 ENOG41082AN stage II sporulation protein EQK04_10600 ENOG4105DZ1 carboxypeptidase EQK04_10605 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EQK04_10610 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EQK04_10615 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EQK04_10625 ENOG4105I3K Ferric uptake regulator, Fur family EQK04_10630 ENOG4105MZ9 stage II sporulation protein m EQK04_10650 ENOG4107YB6 acetyltransferase, (GNAT) family EQK04_10660 ENOG4108YZ4 nudix hydrolase EQK04_10665 ENOG4105CPC Aldo Keto reductase EQK04_10690 ENOG4106HZJ EQK04_10695 ENOG4108YQE rare lipoprotein a EQK04_10700 ENOG4105RHY Pfam:UPF0157 EQK04_10705 ENOG4108XET gCN5-related N-acetyltransferase EQK04_10715 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQK04_10725 ENOG4105E5W Transporter EQK04_10735 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EQK04_10745 ENOG4108IXY short-chain dehydrogenase reductase EQK04_10750 ENOG41069FQ Metallo-beta-lactamase superfamily EQK04_10755 ENOG4105II7 pyrroline-5-carboxylate reductase EQK04_10770 ENOG4105D4P Coproporphyrinogen iii oxidase EQK04_10780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EQK04_10790 ENOG4105XT2 Transcriptional regulator EQK04_10795 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EQK04_10800 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EQK04_10805 ENOG4108TZY GntR Family Transcriptional Regulator EQK04_10810 ENOG4105CS2 ec 3.2.1.21 EQK04_10815 ENOG4105CK1 PTS System EQK04_10820 ENOG4105VCP PTS System EQK04_10825 ENOG4105VZJ PTS System EQK04_10835 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EQK04_10840 ENOG4105CSC Glucose uptake protein EQK04_10845 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EQK04_10850 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EQK04_10860 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) EQK04_10865 ENOG4108V3W Chemotaxis protein, CheW EQK04_10870 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQK04_10875 ENOG4108HNZ carboxyl transferase EQK04_10880 ENOG4108ZVT methylmalonyl-coA epimerase EQK04_10885 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EQK04_10890 ENOG4108QEG Membrane EQK04_10895 ENOG4105CDA abc transporter atp-binding protein EQK04_10900 ENOG4105E5Q amino acid AbC transporter EQK04_10905 ENOG4108HW3 (ABC) transporter EQK04_10910 ENOG4108Y6J UPF0403 protein EQK04_10915 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EQK04_10925 ENOG4105C7S Dehydrogenase EQK04_10930 ENOG4105CPP Dehydrogenase, E1 component EQK04_10945 ENOG4105CKM Branched-chain carboxylic acid kinase EQK04_10950 ENOG4107RDP Dehydrogenase EQK04_10960 ENOG4108JUB Transcriptional regulator EQK04_10965 ENOG4106CCJ Protein of unknown function (DUF2627) EQK04_10970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EQK04_10980 ENOG4107QQR Sporulation EQK04_10985 ENOG4105S1Z Stage IV sporulation protein B EQK04_10990 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EQK04_10995 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EQK04_11000 ENOG4105DX0 Hemolysin A EQK04_11005 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EQK04_11010 ENOG4105CTB Polyprenyl synthetase EQK04_11015 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQK04_11020 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EQK04_11025 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EQK04_11030 ENOG4105M7K Involved in the transcription termination process (By similarity) EQK04_11035 ENOG4108ZSR alkaline shock protein EQK04_11040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EQK04_11060 ENOG410644B Stage III sporulation protein af EQK04_11070 ENOG4105KQ4 Stage iii sporulation protein ad EQK04_11075 ENOG4108CQH stage III sporulation protein AC EQK04_11080 ENOG4105KR5 Stage iii sporulation protein EQK04_11085 ENOG4105CD2 stage iii sporulation protein aa EQK04_11095 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EQK04_11100 ENOG4105DC7 peptidase M24 EQK04_11105 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EQK04_11115 ENOG4105CBJ Metal-dependent enzyme EQK04_11130 ENOG4105KST dependent repressor EQK04_11135 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EQK04_11140 ENOG4105WZW rhodanese family EQK04_11145 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EQK04_11155 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EQK04_11160 ENOG4105C0D helicase EQK04_11185 ENOG4105VFR signal peptidase EQK04_11225 ENOG4106855 Competence protein EQK04_11260 ENOG4105C5X domain protein EQK04_11290 ENOG4105E0M Sulfatase EQK04_11305 ENOG4107ZXI Rhomboid family EQK04_11315 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EQK04_11320 ENOG4105WDJ 50S ribosomal protein L33 EQK04_11335 ENOG41068DG YceG-like family EQK04_11340 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQK04_11345 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EQK04_11350 ENOG4105E2Z phosphate ABC transporter (Permease EQK04_11355 ENOG4105C8U phosphate abc transporter EQK04_11360 ENOG4105CVA phosphate EQK04_11365 ENOG4107RF6 penicillin-binding protein EQK04_11375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EQK04_11380 ENOG4105SXS Protein of unknown function (DUF456) EQK04_11390 ENOG4105D9U N-acetyltransferase EQK04_11400 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EQK04_11405 ENOG41063Y9 EQK04_11410 ENOG4108U5J '-nucleotidase EQK04_11415 ENOG41066F8 ROK family EQK04_11420 ENOG4105N80 Ferric uptake regulator, Fur family EQK04_11425 ENOG4105FAV ABC, transporter EQK04_11430 ENOG4105FDK ABC transporter EQK04_11435 ENOG4108JYZ YitT family EQK04_11440 ENOG41069ZM Protein of unknown function (DUF2624) EQK04_11445 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EQK04_11460 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EQK04_11465 ENOG4105EGD dinuclear metal center protein, YbgI family EQK04_11480 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_11485 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EQK04_11490 ENOG4108UPT UPF0178 protein EQK04_11495 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EQK04_11505 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EQK04_11510 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EQK04_11515 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EQK04_11525 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EQK04_11530 ENOG4105KG3 cytidine deaminase EQK04_11535 ENOG4107YR5 Diacylglycerol kinase EQK04_11540 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EQK04_11545 ENOG4105CTJ Metal Dependent Phosphohydrolase EQK04_11550 ENOG4105C9A Phoh family EQK04_11555 ENOG4105EI1 sporulation protein yqfd EQK04_11560 ENOG41068P3 sporulation protein YqfC EQK04_11570 ENOG4105DI5 UPF0365 protein EQK04_11575 ENOG4105F7J membrane-bound serine protease EQK04_11580 ENOG4105KTH gatB Yqey EQK04_11595 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EQK04_11600 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EQK04_11605 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EQK04_11610 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EQK04_11620 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EQK04_11625 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EQK04_11630 ENOG4105CSA Coproporphyrinogen iii oxidase EQK04_11635 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EQK04_11645 ENOG4108ZRV stage ii sporulation protein p EQK04_11660 ENOG4105TQK DNA polymerase iii, delta' subunit EQK04_11670 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EQK04_11675 ENOG4108UK2 deaminase EQK04_11680 ENOG4105KQC Competence protein EQK04_11690 ENOG4108D32 Methyltransferase EQK04_11700 ENOG4108WF2 Metal Dependent Phosphohydrolase EQK04_11705 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EQK04_11710 ENOG410812S Rna-binding protein EQK04_11715 ENOG4105E2X shikimate dehydrogenase EQK04_11720 ENOG4105CQW ribosome biogenesis GTPase YqeH EQK04_11725 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EQK04_11750 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_11775 ENOG4108ZJ4 polysaccharide deacetylase EQK04_11810 ENOG4105CJ1 ABC, transporter EQK04_11835 ENOG4107QNK )-transporter EQK04_11840 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EQK04_11855 ENOG4105CMD Transcriptional regulator, GntR family EQK04_11865 ENOG4105NTK Transcriptional repressor Mpra EQK04_11875 ENOG41080HJ 6-phospho 3-hexuloisomerase EQK04_11880 ENOG4108VA3 3-hexulose-6-phosphate synthase EQK04_11885 ENOG4105KVH Transcriptional regulator EQK04_11955 ENOG4108HWY Beta-lactamase EQK04_11960 ENOG4105FDT acyl-CoA dehydrogenase EQK04_11980 ENOG4105E5Q amino acid AbC transporter EQK04_11985 ENOG4105WEF catalase EQK04_12000 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EQK04_12015 ENOG4107V2S Transcriptional regulator EQK04_12020 ENOG4108KYE ABC-2 type transporter EQK04_12025 ENOG41090VJ ABC-2 type transporter EQK04_12030 ENOG4105CJ1 ABC, transporter EQK04_12035 ENOG4105E2A Dehydrogenase EQK04_12060 ENOG4105C28 cystathionine EQK04_12070 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EQK04_12075 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EQK04_12090 ENOG4107XRG penicillin-binding protein EQK04_12095 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EQK04_12100 ENOG4107S03 uridine kinase EQK04_12105 ENOG4105CFP Peptidase U32 EQK04_12110 ENOG4105XYU peptidase (U32 family) EQK04_12120 ENOG4105HHA aminodeoxychorismate lyase EQK04_12130 ENOG4107F3J Amp-dependent synthetase and ligase EQK04_12135 ENOG4107ZYJ bioY protein EQK04_12140 ENOG4105VPH UPF0473 protein EQK04_12145 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EQK04_12150 ENOG4105VBH UPF0297 protein EQK04_12160 ENOG4105C02 permease EQK04_12165 ENOG4105CDA abc transporter atp-binding protein EQK04_12170 ENOG4105CT1 (ABC) transporter EQK04_12175 ENOG4105EAD ABC transporter EQK04_12180 ENOG4105DRP amino acid AbC transporter EQK04_12190 ENOG41060CR EQK04_12200 ENOG4105C7H Helicase, RecD TraA family EQK04_12210 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EQK04_12215 ENOG4105C3J Cysteine desulfurase EQK04_12225 ENOG4105D1H recombination factor protein RarA EQK04_12230 ENOG4105CUZ uba thif-type nad fad binding protein EQK04_12240 ENOG4105C9M aspartyl-trna synthetase EQK04_12245 ENOG4105CUT histidyl-tRNA synthetase EQK04_12250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQK04_12255 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EQK04_12260 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EQK04_12265 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EQK04_12270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EQK04_12275 ENOG41067VP Protein of unknown function (DUF1049) EQK04_12280 ENOG4105NCW Trka-c domain protein EQK04_12285 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EQK04_12295 ENOG4105CKP Polysaccharide Biosynthesis Protein EQK04_12300 ENOG4108QG2 Membrane EQK04_12305 ENOG4105NAP EQK04_12310 ENOG4105VIE preprotein translocase, subunit YajC EQK04_12315 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EQK04_12320 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EQK04_12325 ENOG41061AI Protein of unknown function (DUF2905) EQK04_12330 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EQK04_12335 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EQK04_12355 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EQK04_12370 ENOG4106678 morphogenetic protein associated with SpoVID EQK04_12375 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EQK04_12380 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EQK04_12385 ENOG4108IYU L-aspartate oxidase EQK04_12400 ENOG4105CQC Prephenate dehydratase EQK04_12410 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EQK04_12420 ENOG4105K46 50S ribosomal protein l27 EQK04_12425 ENOG4105X36 (ribosomal) protein EQK04_12430 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EQK04_12445 ENOG4107QMS site-determining protein EQK04_12450 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EQK04_12455 ENOG4105YHC Rod shape-determining protein MreD EQK04_12465 ENOG4105DFF Rod shape-determining protein mreb EQK04_12470 ENOG4105W5Q DNA repair protein (RadC EQK04_12475 ENOG4108Z03 MAF-like protein EQK04_12485 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EQK04_12490 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EQK04_12495 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EQK04_12505 ENOG4106AR7 Spore coat protein EQK04_12510 ENOG41068KH stage VI sporulation protein D EQK04_12515 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EQK04_12520 ENOG4105D52 delta-aminolevulinic acid dehydratase EQK04_12530 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EQK04_12540 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EQK04_12560 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EQK04_12565 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EQK04_12570 ENOG4108IUQ atp-dependent protease EQK04_12575 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EQK04_12580 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EQK04_12590 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQK04_12595 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EQK04_12600 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EQK04_12605 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EQK04_12610 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EQK04_12615 ENOG4108ZP8 Acetolactate synthase small subunit EQK04_12620 ENOG4105C7K acetolactate synthase EQK04_12625 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQK04_12630 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EQK04_12640 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EQK04_12650 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EQK04_12655 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EQK04_12690 ENOG4107SCJ type I restriction enzyme EcoKI subunit R EQK04_12695 ENOG4107EV6 Inherit from COG: YD repeat protein EQK04_12710 ENOG4105M59 Phosphodiesterase, mj0936 family EQK04_12715 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EQK04_12720 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EQK04_12725 ENOG4108XJQ germination protein EQK04_12730 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EQK04_12735 ENOG41067TZ transcriptional regulator, MarR family EQK04_12740 ENOG4105PFC Transcriptional regulator EQK04_12765 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EQK04_12800 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EQK04_12880 ENOG4105CAR Terminase, large subunit EQK04_12925 ENOG410682Q Phage transcriptional regulator, ArpU EQK04_13005 ENOG4105PFC Transcriptional regulator EQK04_13015 ENOG4108KAM Transcriptional regulator EQK04_13020 ENOG4105C7F AcnD-accessory protein PrpF EQK04_13025 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EQK04_13035 ENOG4105E33 succinate dehydrogenase EQK04_13045 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EQK04_13060 ENOG4105CFH Aspartokinase EQK04_13065 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EQK04_13070 ENOG4105K63 Thioredoxin EQK04_13075 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EQK04_13080 ENOG4105C10 Electron transfer flavoprotein EQK04_13085 ENOG4105BZJ Electron transfer flavoprotein EQK04_13090 ENOG41060WC Enoyl-CoA hydratase EQK04_13095 ENOG4107Z3H Transcriptional regulator, TetR family EQK04_13100 ENOG4105CEY Amp-dependent synthetase and ligase EQK04_13115 ENOG4105C98 muts2 protein EQK04_13120 ENOG4105DCG PHP domain protein EQK04_13130 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EQK04_13135 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EQK04_13140 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EQK04_13145 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EQK04_13150 ENOG4108RWN rrna methyltransferase EQK04_13155 ENOG41067MF small acid-soluble spore protein EQK04_13165 ENOG4105CN9 Peptidase m42 family protein EQK04_13175 ENOG410696E Membrane EQK04_13180 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EQK04_13185 ENOG4105VJV 50s ribosomal protein L35 EQK04_13190 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EQK04_13205 ENOG4107SDU Methyl-accepting chemotaxis EQK04_13210 ENOG4105C22 threonyL-tRNA synthetase EQK04_13220 ENOG4108TDW sporulation protein YtxC EQK04_13240 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EQK04_13250 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EQK04_13255 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQK04_13260 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EQK04_13270 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EQK04_13275 ENOG4105C2M dna polymerase I EQK04_13280 ENOG4105BZU Histidine kinase EQK04_13285 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQK04_13290 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EQK04_13295 ENOG4108HMX isocitrate dehydrogenase (NADP) EQK04_13300 ENOG4105BZN citrate synthase EQK04_13305 ENOG4107CWS Protein of unknown function (DUF441) EQK04_13310 ENOG4108REF Sporulation integral membrane protein ytvi EQK04_13315 ENOG4105FS0 cytoplasmic membrane protein EQK04_13320 ENOG4105CA9 Pyruvate kinase EQK04_13325 ENOG4105CTQ phosphohexokinase EQK04_13335 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EQK04_13340 ENOG4105C6K Malic enzyme EQK04_13345 ENOG4105C0B DNA polymerase III (alpha subunit) EQK04_13350 ENOG4105VV2 EQK04_13360 ENOG4106EVM EQK04_13365 ENOG4105SFS phosphoesterase RecJ domain protein EQK04_13385 ENOG4105E8R UPF0173 metal-dependent hydrolase EQK04_13400 ENOG4105CH7 arginosuccinase EQK04_13405 ENOG4105CDH Citrulline--aspartate ligase EQK04_13410 ENOG4105EPU Molybdenum cofactor synthesis domain protein EQK04_13415 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EQK04_13425 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EQK04_13430 ENOG4105KBJ sporulation protein ytfj EQK04_13440 ENOG4105VK3 rdd domain containing protein EQK04_13445 ENOG4105D07 Signal peptide peptidase, SppA EQK04_13450 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EQK04_13455 ENOG4105C1J atp-dependent rna helicase EQK04_13460 ENOG4105ECK Fatty Acid Desaturase EQK04_13465 ENOG4108ZGX Histidine kinase EQK04_13470 ENOG4108S01 response regulator EQK04_13480 ENOG4105CJZ response regulator EQK04_13485 ENOG4105EWM Histidine kinase EQK04_13490 ENOG4105C19 ABC transporter EQK04_13500 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EQK04_13505 ENOG4108X0B nad(p)h dehydrogenase (quinone) EQK04_13520 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EQK04_13525 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EQK04_13535 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EQK04_13565 ENOG4105U5Y Transcriptional regulator EQK04_13575 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EQK04_13595 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EQK04_13600 ENOG4105KAC Antibiotic biosynthesis monooxygenase EQK04_13605 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EQK04_13615 ENOG4105F1V Acetoin utilization protein EQK04_13620 ENOG4105W87 Cbs domain EQK04_13625 ENOG4105DGU Histone deacetylase EQK04_13630 ENOG4105ETE Transcriptional regulator (LacI family EQK04_13635 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EQK04_13655 ENOG4105DFU Cell wall formation (By similarity) EQK04_13665 ENOG4108VDD TRNA binding domain protein EQK04_13670 ENOG4108NKM UPF0354 protein EQK04_13685 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EQK04_13700 ENOG4105C6K Malic enzyme EQK04_13705 ENOG4105C8F Beta-lactamase domain protein EQK04_13710 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EQK04_13720 ENOG4108V15 phosphotransferase enzyme family EQK04_13735 ENOG4107F58 2'-5' rna ligase EQK04_13740 ENOG4105C6T cysteine synthase EQK04_13745 ENOG4107UIE peptidase EQK04_13750 ENOG4107QSE Dipeptidase EQK04_13755 ENOG4105C7N Xanthine uracil vitamin C permease EQK04_13760 ENOG4105YW5 deoR family transcriptional regulator EQK04_13775 ENOG4105CBX hi0933 family EQK04_13785 ENOG4105C94 Transporter EQK04_13790 ENOG4106611 bacteriocin immunity EQK04_13800 ENOG41085GJ domain protein EQK04_13805 ENOG4105MU9 integral membrane protein EQK04_13810 ENOG4105DDC Oxidoreductase domain protein EQK04_13820 ENOG4105F5H Glycosyl Hydrolase Family 88 EQK04_13830 ENOG41075H3 AraC family transcriptional regulator EQK04_13835 ENOG4105KVH Transcriptional regulator EQK04_13840 ENOG4105F27 Major Facilitator EQK04_13845 ENOG4105CV8 reductase EQK04_13855 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EQK04_13865 ENOG4105NTD Inherit from COG: Hydrolase EQK04_13870 ENOG4105C8T Leucyl-tRNA synthetase EQK04_13880 ENOG4105BZU Histidine kinase EQK04_13885 ENOG4106UBQ EQK04_13890 ENOG4107R34 abc transporter permease protein EQK04_13895 ENOG4105C19 ABC transporter EQK04_13905 ENOG4105DVE abc transporter atp-binding protein EQK04_13910 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EQK04_13930 ENOG4105N5T Radical SAM Protein EQK04_13940 ENOG4108N23 SpoOM-related protein EQK04_13950 ENOG4105E8V Alpha Beta Hydrolase Fold protein EQK04_13955 ENOG4108Z0R Transferase EQK04_13960 ENOG4105CAQ asparagine synthetase EQK04_13965 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EQK04_13985 ENOG4105EWK phytoene EQK04_14005 ENOG4105D2X ABC transporter substrate-binding protein EQK04_14015 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EQK04_14025 ENOG4106FN3 tellurium resistance protein EQK04_14050 ENOG4108RMU ferritin dps family protein EQK04_14065 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EQK04_14070 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EQK04_14075 ENOG4108V2W Carbonate dehydratase EQK04_14080 ENOG4105DSE periplasmic solute binding protein EQK04_14085 ENOG4105NRA 50s ribosomal protein l31 type b EQK04_14115 ENOG4105DTQ mandelate racemase muconate lactonizing EQK04_14125 ENOG4108IPT Naphthoate synthase EQK04_14130 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EQK04_14135 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EQK04_14140 ENOG4105E4F Isochorismate synthase EQK04_14145 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EQK04_14155 ENOG4108606 TspO/MBR family EQK04_14280 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EQK04_14290 ENOG4105VRR gCN5-related N-acetyltransferase EQK04_14300 ENOG4105CNI cell division protein FtsW EQK04_14305 ENOG4105CNI cell division protein FtsW EQK04_14310 ENOG4105DZ6 Band 7 protein EQK04_14320 ENOG4106DF1 EQK04_14325 ENOG4108JB8 alcohol dehydrogenase EQK04_14335 ENOG4105TRT Transcriptional regulator EQK04_14350 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EQK04_14375 ENOG41068G1 EQK04_14380 ENOG41068G1 EQK04_14405 ENOG410906S phage-like element pbsx protein xkdt EQK04_14410 ENOG41066EA baseplate J family protein EQK04_14415 ENOG4105MFU Protein of unknown function (DUF2634) EQK04_14425 ENOG4105X7F EQK04_14430 ENOG4108WZM domain protein EQK04_14435 ENOG4108FKH Transglycosylase SLT domain EQK04_14435 ENOG4108FKH Transglycosylase SLT domain EQK04_14445 ENOG4105MTC XkdN-like protein EQK04_14455 ENOG4105FR7 XkdM protein, phage-like element PBSX EQK04_14460 ENOG4105PQS phage protein EQK04_14475 ENOG41060SN EQK04_14500 ENOG4108MDF Phage Portal Protein EQK04_14505 ENOG4105IG6 Phage terminase, large subunit EQK04_14525 ENOG4105QBX endodeoxyribonuclease RusA EQK04_14550 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EQK04_14560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EQK04_14575 ENOG4105EE0 oxidoreductase EQK04_14580 ENOG4108Z0Z intracellular protease Pfpi family EQK04_14585 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_14590 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_14595 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_14600 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_14615 ENOG4105EA8 2-Nitropropane dioxygenase EQK04_14620 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EQK04_14625 ENOG4105C37 (CBS) domain EQK04_14640 ENOG4107PBV potassium channel EQK04_14655 ENOG4107QYV phosphohexose isomerase EQK04_14665 ENOG4107QW4 alcohol dehydrogenase EQK04_14670 ENOG4105WG9 Conserved Protein EQK04_14680 ENOG4105CHM Aminotransferase EQK04_14685 ENOG4108ZB6 transcriptional regulator AsnC family EQK04_14690 ENOG4108MUZ hydrolase EQK04_14700 ENOG4105C87 Aminotransferase class I and II EQK04_14705 ENOG4108HGU Histidine kinase EQK04_14710 ENOG4105Y38 Kinase-associated protein B EQK04_14725 ENOG4105BZ4 penicillin-binding protein EQK04_14730 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EQK04_14745 ENOG4108MRH transcriptional regulatory protein EQK04_14750 ENOG4105DIH basic membrane EQK04_14755 ENOG4108JQ9 ABC transporter EQK04_14760 ENOG4105UIB (ABC) transporter EQK04_14780 ENOG4105D65 subunit l EQK04_14785 ENOG4105HC0 Na H antiporter EQK04_14790 ENOG4108ZE9 Monovalent cation H antiporter subunit C EQK04_14795 ENOG4108JPZ Monovalent cation H antiporter subunit D EQK04_14800 ENOG4105SC1 monovalent cation H antiporter subunit E EQK04_14810 ENOG4105KJM monovalent cation h antiporter subunit g EQK04_14815 ENOG4105KA0 thioesterase Superfamily protein EQK04_14825 ENOG4105BZU Histidine kinase EQK04_14850 ENOG4105D58 Diguanylate phosphodiesterase EQK04_14855 ENOG4105DAP Nicotinate phosphoribosyltransferase EQK04_14885 ENOG4105C02 permease EQK04_14905 ENOG410904N short-chain dehydrogenase reductase EQK04_14940 ENOG4108K8K Transcriptional regulator EQK04_14945 ENOG4105DCF alanine dehydrogenase EQK04_14960 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EQK04_14970 ENOG41069ER domain protein EQK04_14980 ENOG4105CEP NADH dehydrogenase EQK04_14985 ENOG4105CAY ferredoxin--nadp reductase EQK04_15000 ENOG4107TXC Transcriptional regulator EQK04_15010 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EQK04_15015 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EQK04_15020 ENOG4105ZKE UPF0349 protein EQK04_15040 ENOG41083MR nifu domain-containing protein EQK04_15045 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EQK04_15055 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EQK04_15060 ENOG4105D6E homoserine dehydrogenase EQK04_15065 ENOG4105C5I Dehydrogenase EQK04_15075 ENOG4108W5N phosphatidylglycerophosphatase a EQK04_15095 ENOG4105D4U had-superfamily hydrolase, subfamily iia EQK04_15105 ENOG4105MMD transcriptional regulator EQK04_15110 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EQK04_15120 ENOG4105FAA peptidase M23 EQK04_15135 ENOG4108YTE sporulation protein YunB EQK04_15140 ENOG4105KZD Domain of unknown function (DUF1805) EQK04_15145 ENOG4107R8B 5'-nucleotidase EQK04_15150 ENOG4105I3N Conserved Protein EQK04_15155 ENOG4105G9B Transcriptional regulator EQK04_15160 ENOG4105F0F Oxalate decarboxylase EQK04_15170 ENOG4105C5R Aminotransferase EQK04_15175 ENOG4108K8S endonuclease I EQK04_15185 ENOG4108IHU transport system permease protein EQK04_15190 ENOG4105DQ5 transport system permease protein EQK04_15195 ENOG4108MES Periplasmic binding protein EQK04_15215 ENOG4108SWU Histidine kinase EQK04_15220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQK04_15225 ENOG4105DHF Membrane EQK04_15235 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EQK04_15245 ENOG4108IG5 Transcriptional regulator EQK04_15260 ENOG4105DIW FeS assembly protein SUFB EQK04_15265 ENOG4108UNV SUF system FeS assembly protein, NifU family EQK04_15270 ENOG4105C9B Cysteine desulfurase EQK04_15275 ENOG4105JRK feS assembly protein SufD EQK04_15280 ENOG4105C3K feS assembly ATPase SufC EQK04_15290 ENOG4105D01 (LipO)protein EQK04_15295 ENOG4108UMI ABC transporter, permease EQK04_15300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EQK04_15325 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EQK04_15330 ENOG41080E8 Transcriptional regulator, Spx MgsR family EQK04_15335 ENOG4105C1G acyl-Coa dehydrogenase EQK04_15340 ENOG4105CHU acetyl-coa acetyltransferase EQK04_15370 ENOG4105E0A ABC, transporter EQK04_15380 ENOG4105E1F short-chain dehydrogenase reductase EQK04_15390 ENOG4105C0H protease EQK04_15400 ENOG4105F3H Histidine kinase EQK04_15405 ENOG41067SE Tetr family transcriptional regulator EQK04_15410 ENOG4105C9Q fumarate hydratase class II EQK04_15440 ENOG4105WH1 Two component transcriptional regulator luxr family EQK04_15445 ENOG4105ENE Histidine kinase EQK04_15460 ENOG41087YS Phage shock protein A EQK04_15470 ENOG4108WBT adenosyltransferase EQK04_15475 ENOG4105CHR reductase EQK04_15480 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EQK04_15485 ENOG4107S2N Type III effector Hrp-dependent EQK04_15490 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EQK04_15505 ENOG4105C0A alcohol dehydrogenase EQK04_15510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EQK04_15515 ENOG4105E0A ABC, transporter EQK04_15520 ENOG4105EHG Permease protein EQK04_15525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EQK04_15535 ENOG4105CTX dehydratase EQK04_15540 ENOG4107QZW Altronate oxidoreductase EQK04_15545 ENOG4107KJX Transcriptional regulator EQK04_15550 ENOG4105D2H Uronic isomerase EQK04_15560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EQK04_15565 ENOG4105E0A ABC, transporter EQK04_15570 ENOG4105EHG Permease protein EQK04_15575 ENOG4105DQ5 transport system permease protein EQK04_15585 ENOG4105D5Q Arginine ornithine antiporter EQK04_15605 ENOG4107K5X Membrane-bound metal-dependent hydrolase EQK04_15610 ENOG4107QZ2 Sulfatase EQK04_15615 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EQK04_15620 ENOG4105E0C molybdate abc transporter EQK04_15630 ENOG4105EVU fructokinase EQK04_15635 ENOG4107SUZ Sodium/hydrogen exchanger family EQK04_15640 ENOG4105EN6 Membrane EQK04_15650 ENOG4107ZQN disulfide bond EQK04_15655 ENOG4105C59 p-type ATPase EQK04_15660 ENOG4105DIK (ABC) transporter EQK04_15665 ENOG4105CC5 ABC transporter EQK04_15670 ENOG4105DSE periplasmic solute binding protein EQK04_15675 ENOG4105IIP Membrane EQK04_15680 ENOG4105W1N transcriptional regulator EQK04_15695 ENOG4108IJ0 Aspartate ammonia-lyase EQK04_15710 ENOG4105C59 p-type ATPase EQK04_15715 ENOG410681U heavy metal transport detoxification protein EQK04_15720 ENOG4105VPX protein, conserved in bacteria EQK04_15755 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EQK04_15760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EQK04_15770 ENOG4105XZU Preprotein translocase, subunit SecG EQK04_15795 ENOG4105KVH Transcriptional regulator EQK04_15800 ENOG4105R40 Glycine betaine carnitine choline EQK04_15805 ENOG4108HQR Glycine betaine EQK04_15810 ENOG4105E90 ABC transporter EQK04_15815 ENOG4108IJ8 ABC transporter EQK04_15820 ENOG4107HG4 Transcriptional regulator EQK04_15825 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EQK04_15835 ENOG4108W0I acetyltransferase EQK04_15865 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EQK04_15875 ENOG4105CP7 Triose-phosphate isomerase EQK04_15880 ENOG4105BZA Phosphoglycerate kinase EQK04_15885 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EQK04_15900 ENOG4105C8Y Acetylornithine aminotransferase EQK04_15905 ENOG4108JUB Transcriptional regulator EQK04_15910 ENOG4105JXH GntR family transcriptional regulator EQK04_15915 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EQK04_15925 ENOG4107R73 Mate efflux family protein EQK04_15930 ENOG4108JQ7 (ABC) transporter EQK04_15935 ENOG4105C3U ABC transporter EQK04_15940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EQK04_15945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQK04_15950 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EQK04_15955 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQK04_15960 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EQK04_15965 ENOG4105D3Q Sugar transferase EQK04_15980 ENOG4107QRS glycosyltransferase group 2 family protein EQK04_15985 ENOG41068W6 Capsular polysaccharide biosynthesis protein EQK04_15990 ENOG4108KMV Glycosyl transferase (Group 1 EQK04_15995 ENOG4105K64 Glycosyl transferase, family 2 EQK04_16000 ENOG4108PQP glycosyl transferase group 1 EQK04_16010 ENOG4108QV3 biosynthesis protein EQK04_16015 ENOG4105HTX biosynthesis protein EQK04_16030 ENOG4108V5C ABC transporter EQK04_16035 ENOG4105EHG Permease protein EQK04_16040 ENOG4105DQ5 transport system permease protein EQK04_16045 ENOG4108ZJ4 polysaccharide deacetylase EQK04_16055 ENOG4108JQ7 (ABC) transporter EQK04_16070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EQK04_16075 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EQK04_16105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EQK04_16110 ENOG4108URH decarboxylase EQK04_16115 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain EQK04_16120 ENOG4105CHH sulfate transporter EQK04_16125 ENOG4108V2W Carbonate dehydratase EQK04_16130 ENOG4105C5I Dehydrogenase EQK04_16145 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EQK04_16150 ENOG4105KRI phosphocarrier protein (HPr EQK04_16155 ENOG4105CIE May be required for sporulation (By similarity) EQK04_16160 ENOG4105CHW UPF0052 protein EQK04_16165 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EQK04_16170 ENOG4108Z4K mutator MutT protein EQK04_16175 ENOG4105C3M thioredoxin reductase EQK04_16190 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EQK04_16195 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EQK04_16200 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EQK04_16205 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EQK04_16210 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EQK04_16215 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EQK04_16220 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EQK04_16225 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EQK04_16240 ENOG4108RYK Nad-dependent epimerase dehydratase EQK04_16245 ENOG4108Z40 Transcriptional regulator EQK04_16250 ENOG4108S4C acetyltransferase EQK04_16255 ENOG4107XGZ Hydrolase EQK04_16260 ENOG4105HKU nucleoside recognition domain-containing protein EQK04_16270 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EQK04_16275 ENOG4105CE4 GlcNAc 6-P deacetylase EQK04_16280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EQK04_16290 ENOG41088CQ domain protein EQK04_16295 ENOG41086DT Membrane protein of unknown function EQK04_16300 ENOG41067S9 phage shock protein C, PspC EQK04_16305 ENOG4108PY7 EQK04_16320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EQK04_16325 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EQK04_16340 ENOG4105MKU Transcriptional regulator EQK04_16355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQK04_16360 ENOG4105BZU Histidine kinase EQK04_16365 ENOG4105EDW glycosyl transferase, family 39 EQK04_16370 ENOG4105CKK Glycosyl transferase, family 2 EQK04_16380 ENOG4108RCM Nitroreductase EQK04_16385 ENOG4105KVH Transcriptional regulator EQK04_16400 ENOG4105CN1 protease EQK04_16415 ENOG4105CRP Part of the ABC transporter FtsEX involved in EQK04_16420 ENOG4105CAK Cell division ATP-binding protein ftsE EQK04_16455 ENOG4105MS2 ribosomal subunit Interface protein EQK04_16460 ENOG4105C8Q Methyl-accepting chemotaxis EQK04_16475 ENOG4105MQ3 flagellar protein FliS EQK04_16480 ENOG4107RT6 flagellar hook-associated EQK04_16485 ENOG41083S7 flagellar protein FlaG EQK04_16490 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EQK04_16495 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EQK04_16500 ENOG4105MKD EQK04_16505 ENOG4105DTJ flagellar hook-associated protein EQK04_16510 ENOG4105E1Q flagellar hook-associated protein EQK04_16525 ENOG4105RU3 EQK04_16530 ENOG41081UC Inherit from COG: Competence protein EQK04_16550 ENOG4105WH1 Two component transcriptional regulator luxr family EQK04_16555 ENOG4105BZU Histidine kinase EQK04_16560 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EQK04_16565 ENOG4108KGH TRANSCRIPTIONal EQK04_16570 ENOG4105ESV Glycosyl transferase, family 4 EQK04_16575 ENOG4107EF8 Glycosyl transferase (Group 1 EQK04_16590 ENOG4105QZI O-Antigen Polymerase EQK04_16595 ENOG4105C1B dTDP-glucose 4-6-dehydratase EQK04_16600 ENOG4105C6Y Udp-glucose 6-dehydrogenase EQK04_16605 ENOG4107RA4 Glycosyl transferase (Group 1 EQK04_16610 ENOG4105PSV Polysaccharide Biosynthesis Protein EQK04_16615 ENOG4105D3Q Sugar transferase EQK04_16625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQK04_16630 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EQK04_16635 ENOG4105JFG SpoIID LytB domain protein EQK04_16645 ENOG4108KGH TRANSCRIPTIONal EQK04_16650 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EQK04_16655 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EQK04_16660 ENOG4105EY8 ABC transporter EQK04_16670 ENOG4107SJB teichoic acid biosynthesis EQK04_16675 ENOG4107SJB teichoic acid biosynthesis EQK04_16685 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase EQK04_16695 ENOG4107RZX Teichoic acid biosynthesis protein EQK04_16705 ENOG4105DG6 mannose-6-phosphate isomerase EQK04_16715 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EQK04_16720 ENOG4108JP0 extracellular solute-binding protein family 1 EQK04_16725 ENOG4105WH1 Two component transcriptional regulator luxr family EQK04_16730 ENOG4105C2F Histidine kinase EQK04_16740 ENOG4105I4A GCN5-related N-acetyltransferase EQK04_16745 ENOG4108UHU Aldolase EQK04_16750 ENOG4105D7K pfkb domain protein EQK04_16755 ENOG4108M60 Transcriptional regulator EQK04_16760 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) EQK04_16765 ENOG4105CHR reductase EQK04_16780 ENOG4108NHD germination protein EQK04_16785 ENOG4107RGC Glycosyl transferase, family 2 EQK04_16790 ENOG4105C54 Major Facilitator superfamily EQK04_16795 ENOG4108KGH TRANSCRIPTIONal EQK04_16800 ENOG4105J7I hydrolase EQK04_16805 ENOG4105K4H Nlp p60 protein EQK04_16810 ENOG4105PNM synthesis protein EQK04_16820 ENOG4105N98 Capsule biosynthesis protein capB EQK04_16840 ENOG4105ETE Transcriptional regulator (LacI family EQK04_16845 ENOG4108RVA ribokinase EQK04_16850 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EQK04_16855 ENOG4105C2J ABC transporter EQK04_16860 ENOG4105CNN ABC, transporter EQK04_16865 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EQK04_16870 ENOG4107XC4 flavin reductase domain protein, FMN-binding EQK04_16875 ENOG4107RSM transcriptional regulator EQK04_16885 ENOG4107FQX Alpha-acetolactate decarboxylase EQK04_16895 ENOG4105CAH Chromate EQK04_16900 ENOG4105FGV Chromate EQK04_16905 ENOG4105C6Y Udp-glucose 6-dehydrogenase EQK04_16910 ENOG4105KBK Zinc finger, swim domain protein EQK04_16915 ENOG4105C0D helicase EQK04_16920 ENOG4105BZU Histidine kinase EQK04_16925 ENOG410667J hydrolase EQK04_16940 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EQK04_16945 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EQK04_16955 ENOG4105CGA flagellar basal-body rod protein FlgG EQK04_16965 ENOG4105DFF Rod shape-determining protein mreb EQK04_16970 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EQK04_16975 ENOG4107MII Sugar-specific transcriptional regulator TrmB EQK04_16980 ENOG4105CZM Major Facilitator EQK04_16985 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EQK04_16990 ENOG41080V3 Major Facilitator superfamily EQK04_16995 ENOG4105EAB amino acid AbC transporter EQK04_17000 ENOG4105E5Q amino acid AbC transporter EQK04_17005 ENOG4105CDA abc transporter atp-binding protein EQK04_17010 ENOG4105BZU Histidine kinase EQK04_17020 ENOG4105FRN stage II sporulation protein EQK04_17025 ENOG4107TCE N-acetyltransferase EQK04_17070 ENOG4105WDJ 50S ribosomal protein L33 EQK04_17075 ENOG4105CKI cobalamin synthesis protein EQK04_17080 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EQK04_17090 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EQK04_17100 ENOG4108J2R molybdopterin oxidoreductase EQK04_17105 ENOG4108TF4 von Willebrand factor, type A EQK04_17120 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQK04_17130 ENOG4106778 Protein of unknown function (DUF1146) EQK04_17140 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EQK04_17145 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EQK04_17150 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EQK04_17155 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EQK04_17175 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EQK04_17185 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EQK04_17190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EQK04_17195 ENOG4108UIC UPF0340 protein EQK04_17200 ENOG4108YZG isomerase EQK04_17205 ENOG4107WAU Protein tyrosine phosphatase EQK04_17215 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EQK04_17225 ENOG4108ZXQ stage ii sporulation protein r EQK04_17235 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EQK04_17240 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EQK04_17250 ENOG4107TT2 Auxin Efflux Carrier EQK04_17255 ENOG4105C6K Malic enzyme EQK04_17260 ENOG4107104 thymidine kinase EQK04_17265 ENOG41082DI 50s ribosomal protein l31 EQK04_17270 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EQK04_17275 ENOG4105CBT Fructose-1,6-bisphosphatase EQK04_17280 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EQK04_17290 ENOG4105D2N Aldolase EQK04_17295 ENOG410812K response regulator receiver protein EQK04_17305 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EQK04_17315 ENOG41081I9 integral membrane protein EQK04_17325 ENOG4105C1G acyl-Coa dehydrogenase EQK04_17330 ENOG4105C1G acyl-Coa dehydrogenase EQK04_17335 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EQK04_17345 ENOG4105DF6 Fe-S oxidoreductase EQK04_17365 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EQK04_17375 ENOG4105BZ1 (ABC) transporter EQK04_17380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EQK04_17390 ENOG4105C75 arginyL-tRNA synthetase EQK04_17395 ENOG410684U Domain of unknown function (DUF1934) EQK04_17405 ENOG4105CYW agmatinase EQK04_17410 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EQK04_17415 ENOG4105BZ4 penicillin-binding protein EQK04_17420 ENOG4108XFG YwhD family EQK04_17425 ENOG4108Z4T Peptidase M50 EQK04_17430 ENOG41069HH 4-oxalocrotonate tautomerase EQK04_17445 ENOG4108KSA LysR family transcriptional regulator EQK04_17450 ENOG4108UZX fmn reductase EQK04_17455 ENOG4105DEN Luciferase family EQK04_17465 ENOG4108XSB acetyltransferase, (GNAT) family EQK04_17480 ENOG4105E5Q amino acid AbC transporter EQK04_17485 ENOG4105CDA abc transporter atp-binding protein EQK04_17495 ENOG4105DCI Phosphohydrolase EQK04_17500 ENOG4105QAT UPF0741 protein EQK04_17505 ENOG4108VCI transcription factor, rsfa family EQK04_17515 ENOG4107QZ7 Cellulose synthase catalytic subunit EQK04_17525 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EQK04_17550 ENOG4107EV6 Inherit from COG: YD repeat protein EQK04_17580 ENOG4105JSC dimethylmenaquinone methyltransferase EQK04_17590 ENOG4108IJ2 phosphate acetyltransferase EQK04_17595 ENOG4107JTW chlorite dismutase EQK04_17600 ENOG4105F27 Major Facilitator EQK04_17610 ENOG4105FCW Major Facilitator superfamily EQK04_17615 ENOG41061WN bacilysin biosynthesis protein EQK04_17620 ENOG4106CHD Bacilysin biosynthesis protein bacB EQK04_17625 ENOG4105CHR reductase EQK04_17630 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase EQK04_17635 ENOG4105CHM Aminotransferase EQK04_17645 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase EQK04_17650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EQK04_17655 ENOG4105C1B dTDP-glucose 4-6-dehydratase EQK04_17660 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EQK04_17665 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG EQK04_17670 ENOG4107TY6 Acylneuraminate cytidylyltransferase EQK04_17680 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD EQK04_17685 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EQK04_17730 ENOG4105C26 Dehydrogenase EQK04_17735 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EQK04_17740 ENOG4108RJ9 Glycosyl transferase, family 2 EQK04_17750 ENOG4105DWF phosphomethylpyrimidine kinase EQK04_17770 ENOG4105C5Y PTS System EQK04_17785 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EQK04_17795 ENOG4105DEN Luciferase family EQK04_17800 ENOG4108DBC nitroreductase EQK04_17815 ENOG41060D1 Quinol oxidase EQK04_17820 ENOG4105CCU oxidase (Subunit III) EQK04_17825 ENOG4105BZ9 Cytochrome C oxidase, subunit I EQK04_17830 ENOG4105E2S oxidase) subunit II EQK04_17845 ENOG4105CMR udp-glucose 4-epimerase EQK04_17850 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EQK04_17865 ENOG4105WH5 Teichoic acid glycosylation protein EQK04_17935 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EQK04_17940 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EQK04_17945 ENOG4105CMU LysR family (Transcriptional regulator EQK04_17950 ENOG4105VAW lrga family EQK04_17955 ENOG41067MG lrgb family EQK04_17960 ENOG4105DR4 Methyltransferase EQK04_17975 ENOG4105E5Q amino acid AbC transporter EQK04_17980 ENOG4107R0W ABC transporter EQK04_17995 ENOG4105CNN ABC, transporter EQK04_18000 ENOG4105C2J ABC transporter EQK04_18005 ENOG4108QGH periplasmic EQK04_18010 ENOG4108M26 parallel beta-helix repeat protein EQK04_18015 ENOG4105CM2 brancheD-chain amino acid aminotransferase EQK04_18030 ENOG4105F8D glycoside hydrolase family 4 EQK04_18035 ENOG4105VCP PTS System EQK04_18040 ENOG4105CK1 PTS System EQK04_18045 ENOG4105VZJ PTS System EQK04_18050 ENOG4105EMD TRANSCRIPTIONal EQK04_18065 ENOG4107R37 Glutamate dehydrogenase EQK04_18090 ENOG4108JJ8 (ABC) transporter EQK04_18095 ENOG4108JJ9 ABC, transporter EQK04_18100 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EQK04_18105 ENOG4105C4M (Ubiquinol oxidase) subunit I EQK04_18110 ENOG4105E0A ABC, transporter EQK04_18115 ENOG4105DQ5 transport system permease protein EQK04_18120 ENOG4108HUF Transporter EQK04_18125 ENOG4105KFN sortase, SrtB family EQK04_18150 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EQK04_18155 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EQK04_18160 ENOG4105KVH Transcriptional regulator EQK04_18165 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EQK04_18170 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EQK04_18175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EQK04_18185 ENOG4107BJW polysaccharide deacetylase EQK04_18190 ENOG4105VCP PTS System EQK04_18195 ENOG4105VZJ PTS System EQK04_18200 ENOG4105CS2 ec 3.2.1.21 EQK04_18210 ENOG4105CK1 PTS System EQK04_18215 ENOG4105EMD TRANSCRIPTIONal EQK04_18240 ENOG4105DFD Na H antiporter EQK04_18245 ENOG4108IJ0 Aspartate ammonia-lyase EQK04_18250 ENOG4105HDK L-asparaginase EQK04_18255 ENOG4108IMY Transcriptional regulator EQK04_18285 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EQK04_18300 ENOG4106KNT transcriptional regulator EQK04_18305 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EQK04_18315 ENOG4105C6Z Gluconate EQK04_18345 ENOG4105CS2 ec 3.2.1.21 EQK04_18350 ENOG4105C5Y PTS System EQK04_18355 ENOG4105CID antiterminator EQK04_18360 ENOG4108XI2 Domain of unknown function (DUF1963) EQK04_18370 ENOG4108W7F transporter, permease EQK04_18375 ENOG4108JJB ABC transporter EQK04_18380 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EQK04_18385 ENOG4105ETU transcriptional activator (TenA EQK04_18420 ENOG41067V3 Antibiotic biosynthesis monooxygenase EQK04_18425 ENOG4108TVJ Nitroreductase EQK04_18430 ENOG4105FS7 Transcriptional regulator EQK04_18435 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EQK04_18440 ENOG4105D9N nucleoside EQK04_18445 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EQK04_18450 ENOG4107RHR regulatoR EQK04_18460 ENOG4105EXC Acyl-transferase EQK04_18465 ENOG4105DXI Major Facilitator superfamily EQK04_18470 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EQK04_18475 ENOG4105HMZ Methyltransferase EQK04_18485 ENOG410667J hydrolase EQK04_18490 ENOG4105W1Y Transcriptional regulator EQK04_18495 ENOG4105EE0 oxidoreductase EQK04_18500 ENOG4105FKZ Methyl-accepting chemotaxis EQK04_18510 ENOG4105F1N DNA alkylation repair EQK04_18515 ENOG4105C6Z Gluconate EQK04_18520 ENOG4105CMG Carbohydrate kinase EQK04_18525 ENOG4106KNT transcriptional regulator EQK04_18565 ENOG4105DUM transcriptional regulator, lysR family EQK04_18575 ENOG4107FKK extracellular solute-binding protein family 1 EQK04_18585 ENOG4105EG2 ABC transporter, permease EQK04_18595 ENOG4105C4C beta-galactosidase EQK04_18600 ENOG4105D4T Citrate transporter EQK04_18610 ENOG4108TU7 Inherit from COG: (ABC) transporter EQK04_18615 ENOG4105CJ1 ABC, transporter EQK04_18620 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EQK04_18625 ENOG4105BZW Glycerate kinase EQK04_18630 ENOG4107QQ0 gntp family EQK04_18635 ENOG4107VHA regulatoR EQK04_18640 ENOG4105YA8 Transcriptional regulator EQK04_18655 ENOG4105C19 ABC transporter EQK04_18665 ENOG410780I phosphoprotein phosphatase activity EQK04_18670 ENOG4105CID antiterminator EQK04_18675 ENOG4105CS2 ec 3.2.1.21 EQK04_18680 ENOG4105C5Y PTS System EQK04_18705 ENOG4105M6F mutator MutT protein EQK04_18720 ENOG4105C85 amino acid EQK04_18725 ENOG4105ETE Transcriptional regulator (LacI family EQK04_18740 ENOG4105E2X shikimate dehydrogenase EQK04_18785 ENOG4105CS2 ec 3.2.1.21 EQK04_18795 ENOG4108S3Y transcriptional regulator EQK04_18810 ENOG4105JAB phenazine biosynthesis protein, phzf family EQK04_18815 ENOG41080UQ Transcriptional regulator EQK04_18835 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EQK04_18840 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EQK04_18865 ENOG4105C4R Atp-dependent dna helicase EQK04_18870 ENOG41088T4 Helicase IV EQK04_18880 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EQK04_18890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EQK04_18900 ENOG4108V7D UPF0397 protein EQK04_18920 ENOG4105WQG acetyltransferase EQK04_18925 ENOG4105C0H protease EQK04_18930 ENOG4105Q2H domain protein EQK04_18945 ENOG4105BZU Histidine kinase EQK04_18950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EQK04_18975 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EQK04_18990 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EQK04_18995 ENOG4105ST3 Transcriptional regulator EQK04_19000 ENOG4106A3M Cytochrome p-450 EQK04_19005 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EQK04_19010 ENOG4105CDU Replicative dna helicase EQK04_19015 ENOG4106K80 EQK04_19025 ENOG4105NIV Esterase EQK04_19030 ENOG410874W AraC family transcriptional regulator EQK04_19040 ENOG4108SA1 esterase EQK04_19050 ENOG4105DJ2 Major Facilitator Superfamily EQK04_19055 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EQK04_19060 ENOG4105BZR domain protein EQK04_19065 ENOG4108XMW Membrane EQK04_19070 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EQK04_19075 ENOG4108P49 AntiSigma factor EQK04_19080 ENOG4105JVQ RNA Polymerase EQK04_19090 ENOG4105CH6 catalase EQK04_19095 ENOG4105CS1 NAD(P)H quinone oxidoreductase EQK04_19100 ENOG4105FBA Phospholipase Carboxylesterase EQK04_19105 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EQK04_19110 ENOG4105E90 ABC transporter EQK04_19115 ENOG4108IJ8 ABC transporter EQK04_19120 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EQK04_19125 ENOG4108UUM single-stranded DNA-binding protein EQK04_19130 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EQK04_19135 ENOG4105C3G gtp-binding protein EQK04_19140 ENOG4105VDK protein, conserved in bacteria EQK04_19160 ENOG4108ZDA Sporulation protein YyaC EQK04_19165 ENOG4105FA0 parb-like partition protein EQK04_19170 ENOG4107QJE Chromosome Partitioning Protein EQK04_19185 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EQK04_19190 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EQK04_19195 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EQK04_19205 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EQK04_19210 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EQK04_19220 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EQK04_19225 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EQK04_19230 ENOG410848D S4 domain protein YaaA EQK04_19235 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EQK04_19245 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQK04_19250 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EQK04_19285 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EQK04_19295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EQK04_19300 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EQK04_19305 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EQK04_19310 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EQK04_19315 ENOG4105FKZ Methyl-accepting chemotaxis EQK04_19325 ENOG4105ZMH deoxynucleoside kinase EQK04_19335 ENOG4105VRS hydrolase family 18 EQK04_19340 ENOG4105GTG Isochorismatase EQK04_19345 ENOG4108Z6B deaminase EQK04_19355 ENOG4105C6E dna polymerase iii EQK04_19360 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EQK04_19365 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EQK04_19375 ENOG41067KS pro-sigma K processing