locus-tag	class	description
TM2_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TM2_00020	COG0592	DNA-directed DNA polymerase activity
TM2_00030	COG2501	S4 domain
TM2_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TM2_00060	COG0187	DNA topoisomerase II activity
TM2_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TM2_00090	COG0516	GMP reductase activity
TM2_00090	COG0517	IMP dehydrogenase activity
TM2_00100	COG1686	Belongs to the peptidase S11 family
TM2_00110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_00120	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TM2_00130	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TM2_00140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TM2_00150	COG0840	transmembrane signaling receptor activity
TM2_00160	COG1428	Deoxynucleoside kinase
TM2_00170	COG1428	Deoxynucleoside kinase
TM2_00180	COG1388	LysM domain
TM2_00180	COG3858	chitin binding
TM2_00190	COG1335	isochorismatase
TM2_00200	COG0590	tRNA wobble adenosine to inosine editing
TM2_00210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TM2_00220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TM2_00230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TM2_00270	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
TM2_00280	COG3853	Toxic anion resistance protein (TelA)
TM2_00290	COG1982	Orn Lys Arg decarboxylase major
TM2_00300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TM2_00310	COG3870	Protein conserved in bacteria
TM2_00320	COG1728	Protein conserved in bacteria
TM2_00330	COG0470	DNA polymerase III
TM2_00340	COG1774	PSP1 C-terminal conserved region
TM2_00350	COG4467	Involved in initiation control of chromosome replication
TM2_00360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TM2_00370	COG2827	Endonuclease containing a URI domain
TM2_00380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TM2_00390	COG2002	toxin-antitoxin pair type II binding
TM2_00400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM2_00400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM2_00410	COG0084	hydrolase, TatD family'
TM2_00420	COG3583	domain protein
TM2_00420	COG3584	3D domain protein
TM2_00430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TM2_00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TM2_00460	COG4466	Protein conserved in bacteria
TM2_00480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TM2_00490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TM2_00500	COG0251	oxidation-reduction process
TM2_00510	COG2088	sporulation resulting in formation of a cellular spore
TM2_00530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TM2_00540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TM2_00550	COG0193	aminoacyl-tRNA hydrolase activity
TM2_00570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TM2_00580	COG2002	toxin-antitoxin pair type II binding
TM2_00590	COG2244	polysaccharide biosynthetic process
TM2_00600	COG3956	TIGRFAM MazG family protein
TM2_00610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TM2_00630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TM2_00640	COG1098	S1 RNA binding domain
TM2_00650	COG2208	phosphoserine phosphatase activity
TM2_00660	COG2304	oxidoreductase activity
TM2_00670	COG0515	serine threonine protein kinase
TM2_00680	COG0037	tRNA processing
TM2_00690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TM2_00700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TM2_00710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TM2_00720	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TM2_00730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TM2_00740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TM2_00750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TM2_00760	COG0512	Glutamine amidotransferase of anthranilate synthase
TM2_00770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TM2_00780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TM2_00790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TM2_00800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TM2_00810	COG1396	sequence-specific DNA binding
TM2_00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TM2_00830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TM2_00840	COG4463	regulation of RNA biosynthetic process
TM2_00850	COG3880	PFAM UvrB UvrC protein
TM2_00860	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TM2_00870	COG0542	response to heat
TM2_00880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TM2_00890	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TM2_00900	COG4956	integral membrane protein (PIN domain superfamily)
TM2_00910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TM2_00920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TM2_00930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TM2_00940	COG1045	serine acetyltransferase
TM2_00950	COG0215	cysteine-tRNA ligase activity
TM2_00960	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TM2_00970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TM2_00980	COG3688	RNA-binding protein containing a PIN domain
TM2_00990	COG1595	DNA-templated transcription, initiation
TM2_01000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TM2_01010	COG0250	Participates in transcription elongation, termination and antitermination
TM2_01030	COG0081	regulation of translation
TM2_01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TM2_01050	COG0222	ribosome binding
TM2_01060	COG2813	Specifically methylates the guanine in position
TM2_01070	COG0085	RNA polymerase activity
TM2_01080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TM2_01090	COG1358	cellular component organization or biogenesis
TM2_01100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TM2_01110	COG0049	tRNA binding
TM2_01120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TM2_01130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TM2_01140	COG0596	Alpha beta hydrolase
TM2_01160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TM2_01170	COG0088	Forms part of the polypeptide exit tunnel
TM2_01180	COG0089	rRNA binding
TM2_01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TM2_01200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TM2_01210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TM2_01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TM2_01230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TM2_01240	COG0255	Belongs to the universal ribosomal protein uL29 family
TM2_01250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TM2_01260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TM2_01270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TM2_01280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TM2_01290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TM2_01300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TM2_01310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TM2_01320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TM2_01330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TM2_01340	COG1841	ribosomal large subunit assembly
TM2_01350	COG0200	Binds to the 23S rRNA
TM2_01360	COG0201	protein transport
TM2_01370	COG0563	adenylate kinase activity
TM2_01380	COG0024	Methionine aminopeptidase
TM2_01390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TM2_01400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TM2_01410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TM2_01420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TM2_01430	COG0202	RNA polymerase activity
TM2_01440	COG0203	ribosomal protein L17
TM2_01450	COG1122	ATPase activity
TM2_01460	COG1122	ATPase activity
TM2_01470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TM2_01480	COG0101	tRNA pseudouridine synthase activity
TM2_01490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TM2_01500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TM2_01510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TM2_01560	COG0860	N-Acetylmuramoyl-L-alanine amidase
TM2_01570	COG0489	protein tyrosine kinase activity
TM2_01590	COG2194	sulfuric ester hydrolase activity
TM2_01600	COG0726	polysaccharide deacetylase
TM2_01630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM2_01640	COG0659	secondary active sulfate transmembrane transporter activity
TM2_01650	COG0385	Bile acid
TM2_01660	COG3876	Protein conserved in bacteria
TM2_01670	COG1472	Belongs to the glycosyl hydrolase 3 family
TM2_01680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TM2_01690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_01690	COG1263	PTS System
TM2_01700	COG1737	Transcriptional regulator
TM2_01710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TM2_01730	COG1595	DNA-templated transcription, initiation
TM2_01740	COG5662	AntiSigma factor
TM2_01750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TM2_01760	COG4856	YbbR-like protein
TM2_01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TM2_01780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TM2_01820	COG1131	(ABC) transporter
TM2_01840	COG0577	efflux transmembrane transporter activity
TM2_01840	COG1136	(ABC) transporter
TM2_01860	COG1695	Transcriptional regulator
TM2_01880	COG1131	(ABC) transporter
TM2_01910	COG1413	lyase activity
TM2_01920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_01940	COG2311	Membrane
TM2_01980	COG1476	TRANSCRIPTIONal
TM2_02000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TM2_02010	COG2207	Transcriptional regulator
TM2_02040	COG1131	(ABC) transporter
TM2_02080	COG1113	amino acid transport
TM2_02090	COG0584	glycerophosphoryl diester phosphodiesterase
TM2_02100	COG2271	Major facilitator Superfamily
TM2_02120	COG1331	Highly conserved protein containing a thioredoxin domain
TM2_02130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TM2_02160	COG1131	(ABC) transporter
TM2_02220	COG1937	Protein conserved in bacteria
TM2_02230	COG2210	Belongs to the sulfur carrier protein TusA family
TM2_02250	COG0425	Belongs to the sulfur carrier protein TusA family
TM2_02250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TM2_02260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TM2_02260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_02270	COG0425	Belongs to the sulfur carrier protein TusA family
TM2_02280	COG0730	response to heat
TM2_02290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TM2_02300	COG2814	Major facilitator Superfamily
TM2_02330	COG1846	Transcriptional regulator
TM2_02340	COG1683	Conserved Protein
TM2_02360	COG0656	L-ascorbic acid biosynthetic process
TM2_02370	COG0371	Dehydrogenase
TM2_02380	COG1054	Belongs to the UPF0176 family
TM2_02390	COG0531	amino acid
TM2_02410	COG3711	transcriptional antiterminator
TM2_02420	COG1263	PTS System
TM2_02420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_02420	COG2190	(PTS) system
TM2_02430	COG2723	6-phospho-beta-galactosidase activity
TM2_02460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_02460	COG3711	transcriptional antiterminator
TM2_02470	COG1940	carbohydrate kinase activity
TM2_02480	COG0383	alpha-mannosidase activity
TM2_02490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_02500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_02510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_02510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_02520	COG1404	Belongs to the peptidase S8 family
TM2_02550	COG0833	amino acid
TM2_02560	COG2040	homocysteine
TM2_02570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM2_02580	COG1695	Transcriptional regulator
TM2_02610	COG2814	Major facilitator Superfamily
TM2_02620	COG0456	acetyltransferase
TM2_02650	COG1404	Belongs to the peptidase S8 family
TM2_02670	COG1309	transcriptional regulator
TM2_02680	COG1917	Cupin 2, conserved barrel domain protein
TM2_02690	COG1846	Transcriptional regulator
TM2_02700	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_02710	COG0531	amino acid
TM2_02730	COG0596	Alpha beta hydrolase
TM2_02740	COG1115	amino acid carrier protein
TM2_02750	COG2066	Belongs to the glutaminase family
TM2_02760	COG4191	Histidine kinase
TM2_02770	COG0784	Response regulator, receiver
TM2_02780	COG3012	SEC-C Motif Domain Protein
TM2_02780	COG1405	negative regulation of cell septum assembly
TM2_02800	COG0667	Aldo Keto reductase
TM2_02810	COG3290	protein histidine kinase activity
TM2_02820	COG3279	Response regulator of the LytR AlgR family
TM2_02830	COG4555	ABC transporter
TM2_02840	COG1668	transmembrane transport
TM2_02880	COG3773	Cell wall hydrolase
TM2_02890	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_02910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_02920	COG2310	stress, protein
TM2_02930	COG2310	stress, protein
TM2_02940	COG2310	stress, protein
TM2_02950	COG0861	Integral membrane protein TerC family
TM2_03010	COG3853	Toxic anion resistance protein (TelA)
TM2_03020	COG0517	IMP dehydrogenase activity
TM2_03020	COG4175	Glycine betaine
TM2_03030	COG4176	ABC-type proline glycine betaine transport system permease component
TM2_03040	COG2113	Glycine betaine
TM2_03070	COG1473	amidohydrolase
TM2_03080	COG1288	antiporter activity
TM2_03090	COG0039	L-malate dehydrogenase activity
TM2_03100	COG1620	l-lactate permease
TM2_03110	COG1609	Transcriptional regulator
TM2_03120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TM2_03130	COG0561	phosphatase activity
TM2_03140	COG0673	inositol 2-dehydrogenase activity
TM2_03150	COG0738	Major facilitator superfamily
TM2_03160	COG1280	lysine exporter protein (LysE YggA)
TM2_03180	COG3403	YqcI/YcgG family
TM2_03190	COG1113	amino acid transport
TM2_03200	COG3665	Urea carboxylase-associated protein
TM2_03210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TM2_03230	COG1012	belongs to the aldehyde dehydrogenase family
TM2_03240	COG0710	3-dehydroquinate dehydratase activity
TM2_03250	COG0028	Belongs to the TPP enzyme family
TM2_03270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TM2_03280	COG2271	Major facilitator Superfamily
TM2_03310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TM2_03320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TM2_03340	COG0477	Major facilitator Superfamily
TM2_03350	COG2226	methyltransferase
TM2_03360	COG0583	DNA-binding transcription factor activity
TM2_03370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TM2_03380	COG3458	cephalosporin-C deacetylase activity
TM2_03400	COG3541	Predicted nucleotidyltransferase
TM2_03410	COG0506	proline dehydrogenase activity
TM2_03420	COG1012	belongs to the aldehyde dehydrogenase family
TM2_03430	COG2508	Transcriptional regulator
TM2_03440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TM2_03450	COG0765	amino acid transport
TM2_03460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_03480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TM2_03490	COG1522	sequence-specific DNA binding
TM2_03500	COG2746	aminoglycoside 3-N-acetyltransferase activity
TM2_03520	COG0840	transmembrane signaling receptor activity
TM2_03520	COG3290	protein histidine kinase activity
TM2_03530	COG3209	COG3209 Rhs family protein
TM2_03570	COG3842	ATPase activity
TM2_03580	COG1176	ABC-type spermidine putrescine transport system, permease component I
TM2_03600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TM2_03610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TM2_03620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TM2_03650	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
TM2_03660	COG0697	spore germination
TM2_03670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_03690	COG3708	Transcriptional regulator
TM2_03690	COG2207	Transcriptional regulator
TM2_03710	COG2364	Membrane
TM2_03720	COG1126	abc transporter atp-binding protein
TM2_03730	COG0765	amino acid transport
TM2_03740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_03750	COG0412	Dienelactone hydrolase
TM2_03760	COG0833	amino acid
TM2_03770	COG3104	oligopeptide transport
TM2_03780	COG5434	Belongs to the glycosyl hydrolase 28 family
TM2_03790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_03800	COG0456	acetyltransferase
TM2_03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_03820	COG0765	amino acid transport
TM2_03830	COG1126	abc transporter atp-binding protein
TM2_03840	COG1473	amidohydrolase
TM2_03850	COG2079	MmgE PrpD family protein
TM2_03870	COG0745	RESPONSE REGULATOR receiver
TM2_03880	COG3850	Histidine kinase
TM2_03880	COG5002	protein histidine kinase activity
TM2_03890	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_03900	COG0527	aspartate kinase activity
TM2_03910	COG2814	Major facilitator Superfamily
TM2_03920	COG1309	transcriptional regulator
TM2_03940	COG0640	Transcriptional regulator
TM2_03960	COG0583	DNA-binding transcription factor activity
TM2_03970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_03980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TM2_03990	COG0531	amino acid
TM2_04000	COG1012	belongs to the aldehyde dehydrogenase family
TM2_04010	COG2249	NAD(P)H dehydrogenase (quinone) activity
TM2_04020	COG4549	nuclear export factor GLE1
TM2_04030	COG1276	copper resistance
TM2_04030	COG2372	response to copper ion
TM2_04040	COG2213	PTS system mannitol-specific
TM2_04050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_04060	COG0246	Mannitol dehydrogenase
TM2_04070	COG0840	transmembrane signaling receptor activity
TM2_04140	COG0346	lactoylglutathione lyase activity
TM2_04160	COG0561	phosphatase activity
TM2_04170	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TM2_04180	COG1914	H( )-stimulated, divalent metal cation uptake system
TM2_04190	COG4336	lyase activity
TM2_04200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TM2_04210	COG1984	allophanate hydrolase subunit 2
TM2_04220	COG1414	Transcriptional regulator
TM2_04230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TM2_04240	COG2755	lipolytic protein G-D-S-L family
TM2_04260	COG3711	transcriptional antiterminator
TM2_04270	COG2226	methyltransferase
TM2_04280	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_04290	COG3871	stress protein (general stress protein 26)
TM2_04320	COG2814	Major facilitator Superfamily
TM2_04330	COG1802	Transcriptional regulator
TM2_04340	COG2207	Transcriptional regulator
TM2_04340	COG1917	Cupin 2, conserved barrel domain protein
TM2_04350	COG0697	spore germination
TM2_04360	COG0473	3-isopropylmalate dehydrogenase activity
TM2_04370	COG0551	DNA topoisomerase type I activity
TM2_04370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TM2_04380	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
TM2_04390	COG3706	GGDEF domain
TM2_04400	COG5298	Protein conserved in bacteria
TM2_04410	COG1215	transferase activity, transferring glycosyl groups
TM2_04440	COG0531	amino acid
TM2_04450	COG0028	Belongs to the TPP enzyme family
TM2_04460	COG5444	nuclease activity
TM2_04500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TM2_04510	COG1914	H( )-stimulated, divalent metal cation uptake system
TM2_04520	COG2261	transglycosylase associated protein
TM2_04530	COG2217	Heavy metal translocating P-type atpase
TM2_04540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TM2_04550	COG3290	protein histidine kinase activity
TM2_04560	COG4565	transcriptional regulatory protein
TM2_04570	COG1301	dicarboxylic acid transport
TM2_04580	COG0628	permease
TM2_04590	COG1301	dicarboxylic acid transport
TM2_04600	COG1131	(ABC) transporter
TM2_04610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TM2_04640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_04650	COG1181	Belongs to the D-alanine--D-alanine ligase family
TM2_04660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TM2_04690	COG0513	Belongs to the DEAD box helicase family
TM2_04700	COG3402	PFAM membrane-flanked domain
TM2_04710	COG3428	Bacterial PH domain
TM2_04720	COG0705	Rhomboid family
TM2_04730	COG0736	holo-[acyl-carrier-protein] synthase activity
TM2_04740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TM2_04750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TM2_04760	COG0864	Transcriptional regulator
TM2_04770	COG2337	Toxic component of a toxin-antitoxin (TA) module
TM2_04780	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_04790	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_04800	COG2172	sigma factor antagonist activity
TM2_04810	COG2208	phosphoserine phosphatase activity
TM2_04820	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_04830	COG2172	sigma factor antagonist activity
TM2_04840	COG1191	sigma factor activity
TM2_04850	COG2208	phosphoserine phosphatase activity
TM2_04860	COG2183	response to ionizing radiation
TM2_04870	COG3091	SprT-like family
TM2_04880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TM2_04890	COG0022	dehydrogenase e1 component
TM2_04900	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_04910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TM2_04920	COG3284	Transcriptional regulator
TM2_04940	COG1278	Cold shock
TM2_04970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_04970	COG1263	PTS System
TM2_04970	COG2190	(PTS) system
TM2_04980	COG3394	polysaccharide catabolic process
TM2_04990	COG3711	transcriptional antiterminator
TM2_05000	COG1064	alcohol dehydrogenase
TM2_05010	COG0789	Transcriptional regulator
TM2_05050	COG0477	Major facilitator Superfamily
TM2_05060	COG0657	acetylesterase activity
TM2_05080	COG4221	oxidoreductase activity
TM2_05090	COG0252	asparaginase activity
TM2_05100	COG2267	carboxylic ester hydrolase activity
TM2_05130	COG2814	Major facilitator Superfamily
TM2_05240	COG1309	transcriptional regulator
TM2_05250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TM2_05260	COG1846	Transcriptional regulator
TM2_05270	COG0778	Nitroreductase
TM2_05300	COG1396	sequence-specific DNA binding
TM2_05320	COG0456	acetyltransferase
TM2_05340	COG4122	O-methyltransferase activity
TM2_05360	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TM2_05370	COG0697	spore germination
TM2_05390	COG1301	dicarboxylic acid transport
TM2_05410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TM2_05420	COG0802	atpase or kinase
TM2_05430	COG1214	PFAM Peptidase M22, glycoprotease
TM2_05440	COG0456	acetyltransferase
TM2_05450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TM2_05460	COG0488	(ABC) transporter
TM2_05470	COG0315	cyclic pyranopterin monophosphate synthase activity
TM2_05480	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TM2_05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TM2_05500	COG0805	protein transport
TM2_05530	COG1266	CAAX protease self-immunity
TM2_05540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TM2_05550	COG0459	protein refolding
TM2_05560	COG1846	Transcriptional regulator
TM2_05570	COG2808	Putative FMN-binding domain
TM2_05580	COG1876	peptidase activity
TM2_05630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TM2_05640	COG0823	Involved in the tonB-independent uptake of proteins
TM2_05660	COG2132	Multicopper oxidase
TM2_05670	COG1113	amino acid transport
TM2_05680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TM2_05690	COG0714	Associated with various cellular activities
TM2_05700	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
TM2_05710	COG1305	Transglutaminase-like
TM2_05720	COG0519	Catalyzes the synthesis of GMP from XMP
TM2_05720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TM2_05770	COG1674	ftsk spoiiie
TM2_05830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TM2_05850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TM2_05860	COG2207	Transcriptional regulator
TM2_05920	COG1595	DNA-templated transcription, initiation
TM2_05940	COG2814	Major facilitator Superfamily
TM2_05950	COG0583	DNA-binding transcription factor activity
TM2_05960	COG2252	PERMEase
TM2_05980	COG5583	Uncharacterized small protein (DUF2292)
TM2_05990	COG3064	Membrane
TM2_06000	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TM2_06020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TM2_06030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TM2_06040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TM2_06050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TM2_06060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TM2_06070	COG0047	phosphoribosylformylglycinamidine synthase activity
TM2_06080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TM2_06090	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TM2_06100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TM2_06110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TM2_06120	COG0138	bifunctional purine biosynthesis protein purh
TM2_06130	COG0151	Belongs to the GarS family
TM2_06180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TM2_06190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TM2_06200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TM2_06210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TM2_06230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TM2_06240	COG4496	protein, YerC YecD
TM2_06260	COG0069	glutamate synthase activity
TM2_06290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TM2_06300	COG0210	DNA helicase
TM2_06310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TM2_06320	COG4851	CamS sex pheromone cAM373 precursor
TM2_06330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TM2_06340	COG1285	pathogenesis
TM2_06350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TM2_06360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TM2_06370	COG0154	amidase activity
TM2_06380	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TM2_06390	COG1309	transcriptional regulator
TM2_06400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TM2_06410	COG1957	nucleoside hydrolase
TM2_06420	COG1597	lipid kinase activity
TM2_06430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TM2_06440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TM2_06470	COG1959	2 iron, 2 sulfur cluster binding
TM2_06480	COG0492	ferredoxin-NADP+ reductase activity
TM2_06520	COG1486	melibiose metabolic process
TM2_06540	COG2211	Major facilitator Superfamily
TM2_06600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TM2_06610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TM2_06620	COG1442	glycosyl transferase family 8
TM2_06630	COG1216	Glycosyl transferase, family 2
TM2_06640	COG1442	glycosyl transferase family 8
TM2_06650	COG2223	nitrite transmembrane transporter activity
TM2_06670	COG0471	metal ion transport
TM2_06700	COG0071	Belongs to the small heat shock protein (HSP20) family
TM2_06730	COG0531	amino acid
TM2_06740	COG0457	Tetratricopeptide repeat
TM2_06740	COG0463	Glycosyl transferase, family 2
TM2_06750	COG0488	(ABC) transporter
TM2_06760	COG1469	GTP cyclohydrolase I activity
TM2_06770	COG0789	Transcriptional regulator
TM2_06780	COG2814	Major facilitator Superfamily
TM2_06790	COG0488	(ABC) transporter
TM2_06800	COG0513	Belongs to the DEAD box helicase family
TM2_06850	COG2801	Transposase and inactivated derivatives
TM2_06860	COG2130	NADP-dependent
TM2_06900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_06900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_06910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TM2_06940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM2_06940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM2_06960	COG3290	protein histidine kinase activity
TM2_06970	COG4565	transcriptional regulatory protein
TM2_06980	COG3181	Tripartite tricarboxylate transporter family receptor
TM2_06990	COG2851	Citrate transporter
TM2_07010	COG3479	Phenolic acid decarboxylase
TM2_07020	COG1695	Transcriptional regulator
TM2_07030	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
TM2_07050	COG1254	Belongs to the acylphosphatase family
TM2_07060	COG2258	MOSC domain
TM2_07090	COG0024	Methionine aminopeptidase
TM2_07100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_07100	COG1263	PTS System
TM2_07110	COG3739	integral membrane protein
TM2_07150	COG1368	sulfuric ester hydrolase activity
TM2_07160	COG0076	glutamate decarboxylase activity
TM2_07170	COG0840	transmembrane signaling receptor activity
TM2_07190	COG1263	PTS System
TM2_07190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_07200	COG0366	Alpha amylase catalytic
TM2_07210	COG2188	Transcriptional regulator
TM2_07230	COG0737	Belongs to the 5'-nucleotidase family
TM2_07240	COG0693	protein deglycase activity
TM2_07250	COG4840	Belongs to the UPF0435 family
TM2_07260	COG1115	amino acid carrier protein
TM2_07270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TM2_07280	COG4980	gas vesicle protein
TM2_07290	COG1295	ribonuclease BN
TM2_07310	COG0477	Major facilitator Superfamily
TM2_07330	COG0387	Pfam Sodium calcium exchanger
TM2_07350	COG0217	transcriptional regulatory protein
TM2_07370	COG0668	transmembrane transport
TM2_07380	COG0535	radical SAM domain protein
TM2_07400	COG0726	polysaccharide deacetylase
TM2_07430	COG0598	Magnesium transport protein CorA
TM2_07450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TM2_07460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TM2_07500	COG1401	restriction endodeoxyribonuclease activity
TM2_07540	COG0789	Transcriptional regulator
TM2_07550	COG2814	Major facilitator Superfamily
TM2_07580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TM2_07670	COG2076	Multidrug Resistance protein
TM2_07680	COG2076	Multidrug Resistance protein
TM2_07690	COG1309	transcriptional regulator
TM2_07700	COG4637	Psort location Cytoplasmic, score
TM2_07710	COG2755	lipolytic protein G-D-S-L family
TM2_07720	COG0492	ferredoxin-NADP+ reductase activity
TM2_07730	COG2169	Transcriptional regulator
TM2_07740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TM2_07750	COG1132	(ABC) transporter
TM2_07760	COG1742	UPF0060 membrane protein
TM2_07770	COG1595	DNA-templated transcription, initiation
TM2_07800	COG2318	DinB family
TM2_07820	COG1846	Transcriptional regulator
TM2_07830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TM2_07830	COG0392	lysyltransferase activity
TM2_07870	COG0778	Nitroreductase
TM2_07890	COG1090	epimerase
TM2_07900	COG2137	regulation of response to DNA damage stimulus
TM2_07950	COG0463	Glycosyl transferase, family 2
TM2_07960	COG4485	Bacterial membrane protein, YfhO
TM2_07970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TM2_07990	COG2140	Oxalate decarboxylase
TM2_08010	COG1191	sigma factor activity
TM2_08030	COG1988	membrane-bound metal-dependent
TM2_08040	COG1194	a g-specific adenine glycosylase
TM2_08060	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_08090	COG3557	Belongs to the UPF0374 family
TM2_08100	COG1132	(ABC) transporter
TM2_08110	COG0444	Belongs to the ABC transporter superfamily
TM2_08120	COG4608	Belongs to the ABC transporter superfamily
TM2_08130	COG0747	negative chemotaxis
TM2_08140	COG0601	transmembrane transport
TM2_08150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM2_08160	COG4129	membrane
TM2_08170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TM2_08180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TM2_08190	COG0735	belongs to the Fur family
TM2_08310	COG1368	sulfuric ester hydrolase activity
TM2_08320	COG0681	Belongs to the peptidase S26 family
TM2_08330	COG2873	o-acetylhomoserine
TM2_08350	COG1116	anion transmembrane transporter activity
TM2_08360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TM2_08370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TM2_08410	COG1131	(ABC) transporter
TM2_08460	COG3382	B3 4 domain protein
TM2_08470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TM2_08490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TM2_08500	COG2766	serine protein kinase
TM2_08510	COG2718	Belongs to the UPF0229 family
TM2_08530	COG1566	PFAM secretion protein HlyD family protein
TM2_08540	COG2814	Major facilitator Superfamily
TM2_08550	COG0655	NAD(P)H dehydrogenase (quinone) activity
TM2_08570	COG1278	Cold shock
TM2_08580	COG3706	GGDEF domain
TM2_08630	COG5577	PFAM Coat F domain
TM2_08640	COG5002	protein histidine kinase activity
TM2_08650	COG4085	toxin activity
TM2_08650	COG0737	Belongs to the 5'-nucleotidase family
TM2_08650	COG1525	nuclease
TM2_08660	COG3764	Sortase (surface protein transpeptidase)
TM2_08670	COG0564	pseudouridine synthase activity
TM2_08690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TM2_08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TM2_08700	COG3153	acetyltransferase
TM2_08740	COG3835	regulator
TM2_08750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TM2_08760	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TM2_08770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TM2_08780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TM2_08790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TM2_08800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TM2_08810	COG2203	Gaf domain
TM2_08810	COG4585	Histidine kinase
TM2_08820	COG2197	response regulator
TM2_08850	COG0753	catalase activity
TM2_08860	COG1959	2 iron, 2 sulfur cluster binding
TM2_08870	COG1017	nitric oxide dioxygenase activity
TM2_08870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TM2_08880	COG2719	SpoVR family
TM2_08890	COG1785	Belongs to the alkaline phosphatase family
TM2_08900	COG0791	NLP P60 protein
TM2_08900	COG1388	LysM domain
TM2_08910	COG0531	amino acid
TM2_08940	COG1595	DNA-templated transcription, initiation
TM2_08950	COG0204	Acyl-transferase
TM2_08960	COG1253	flavin adenine dinucleotide binding
TM2_08970	COG0789	Transcriptional regulator
TM2_08980	COG1253	flavin adenine dinucleotide binding
TM2_09010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TM2_09020	COG0584	glycerophosphoryl diester phosphodiesterase
TM2_09030	COG0668	transmembrane transport
TM2_09040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TM2_09050	COG0726	polysaccharide deacetylase
TM2_09060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TM2_09070	COG0589	response to stress
TM2_09080	COG1132	(ABC) transporter
TM2_09090	COG1132	(ABC) transporter
TM2_09100	COG0702	epimerase
TM2_09120	COG3842	ATPase activity
TM2_09130	COG2508	Transcriptional regulator
TM2_09150	COG0189	ligase activity
TM2_09160	COG0189	ligase activity
TM2_09170	COG4399	Belongs to the UPF0754 family
TM2_09180	COG3679	Belongs to the UPF0342 family
TM2_09190	COG0561	phosphatase activity
TM2_09200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TM2_09220	COG0475	glutathione-regulated potassium exporter activity
TM2_09230	COG0490	domain, Protein
TM2_09240	COG1024	Enoyl-CoA hydratase
TM2_09260	COG0420	3'-5' exonuclease activity
TM2_09270	COG4717	serine-type aminopeptidase activity
TM2_09280	COG3481	metal-dependent phosphohydrolase, HD sub domain
TM2_09300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TM2_09330	COG1846	Transcriptional regulator
TM2_09340	COG4980	gas vesicle protein
TM2_09370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TM2_09380	COG0537	adenosine 5'-monophosphoramidase activity
TM2_09390	COG1131	(ABC) transporter
TM2_09400	COG4473	ABC transporter
TM2_09420	COG1473	amidohydrolase
TM2_09440	COG2329	Antibiotic biosynthesis monooxygenase
TM2_09450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TM2_09460	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TM2_09470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TM2_09480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TM2_09490	COG1309	transcriptional regulator
TM2_09500	COG1511	domain protein
TM2_09510	COG1363	Peptidase, m42
TM2_09520	COG1301	dicarboxylic acid transport
TM2_09540	COG1234	tRNA 3'-trailer cleavage
TM2_09550	COG0095	Lipoate-protein ligase
TM2_09560	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_09580	COG0501	Belongs to the peptidase M48B family
TM2_09590	COG1404	Belongs to the peptidase S8 family
TM2_09600	COG0406	alpha-ribazole phosphatase activity
TM2_09610	COG0840	transmembrane signaling receptor activity
TM2_09620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TM2_09620	COG0723	plastoquinol--plastocyanin reductase activity
TM2_09630	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_09650	COG4903	ComK protein
TM2_09680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_09690	COG2814	Major facilitator Superfamily
TM2_09700	COG2732	(Barnase) inhibitor
TM2_09710	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_09720	COG4605	iron ion homeostasis
TM2_09730	COG4604	ABC transporter, ATP-binding protein
TM2_09740	COG4607	ABC-type enterochelin transport system periplasmic component
TM2_09750	COG1316	TRANSCRIPTIONal
TM2_09780	COG0398	Pfam SNARE associated Golgi protein
TM2_09790	COG0681	Belongs to the peptidase S26 family
TM2_09800	COG3180	Ammonia monooxygenase
TM2_09830	COG2259	Doxx family
TM2_09840	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TM2_09850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
TM2_09860	COG1074	ATP-dependent DNA helicase activity
TM2_09870	COG0420	3'-5' exonuclease activity
TM2_09880	COG0419	ATPase involved in DNA repair
TM2_09890	COG1403	HNH endonuclease
TM2_09970	COG5337	Spore coat protein CotH
TM2_09980	COG0179	Fumarylacetoacetate (FAA) hydrolase
TM2_10010	COG0367	asparagine synthase
TM2_10040	COG1562	ergosterol biosynthetic process
TM2_10050	COG0534	Mate efflux family protein
TM2_10060	COG1917	Cupin 2, conserved barrel domain protein
TM2_10060	COG2207	Transcriptional regulator
TM2_10110	COG0076	glutamate decarboxylase activity
TM2_10180	COG0646	methionine synthase
TM2_10180	COG1410	methionine synthase
TM2_10190	COG0646	methionine synthase
TM2_10190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TM2_10200	COG1666	GTP binding
TM2_10210	COG2996	Protein conserved in bacteria
TM2_10220	COG1744	ABC transporter substrate-binding protein PnrA-like
TM2_10230	COG0840	transmembrane signaling receptor activity
TM2_10240	COG1307	EDD domain protein, DegV family
TM2_10250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM2_10290	COG0561	phosphatase activity
TM2_10300	COG1073	alpha beta
TM2_10310	COG2151	metal-sulfur cluster biosynthetic enzyme
TM2_10320	COG0277	FAD linked oxidase domain protein
TM2_10330	COG2271	Major facilitator Superfamily
TM2_10340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TM2_10350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TM2_10360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TM2_10370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TM2_10380	COG0505	Belongs to the CarA family
TM2_10390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TM2_10400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TM2_10430	COG2814	Major facilitator Superfamily
TM2_10450	COG2267	carboxylic ester hydrolase activity
TM2_10470	COG1744	ABC transporter substrate-binding protein PnrA-like
TM2_10500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TM2_10510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TM2_10520	COG5504	Zn-dependent protease
TM2_10530	COG0444	Belongs to the ABC transporter superfamily
TM2_10540	COG4608	Belongs to the ABC transporter superfamily
TM2_10560	COG0601	transmembrane transport
TM2_10570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM2_10590	COG0180	Tryptophanyl-tRNA synthetase
TM2_10600	COG4166	transmembrane transport
TM2_10610	COG0601	transmembrane transport
TM2_10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM2_10630	COG0444	Belongs to the ABC transporter superfamily
TM2_10640	COG4608	Belongs to the ABC transporter superfamily
TM2_10660	COG0456	acetyltransferase
TM2_10670	COG1393	Belongs to the ArsC family
TM2_10680	COG0861	Integral membrane protein TerC family
TM2_10690	COG4862	establishment of competence for transformation
TM2_10700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TM2_10720	COG1164	Oligoendopeptidase f
TM2_10740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TM2_10750	COG2346	COG2346, Truncated hemoglobins
TM2_10760	COG0741	lytic transglycosylase activity
TM2_10770	COG4116	CYTH
TM2_10790	COG2357	RelA SpoT domain protein
TM2_10800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TM2_10810	COG0564	pseudouridine synthase activity
TM2_10820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TM2_10830	COG0569	domain protein
TM2_10830	COG0475	glutathione-regulated potassium exporter activity
TM2_10840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TM2_10850	COG0352	thiamine-phosphate diphosphorylase activity
TM2_10870	COG2104	thiamine diphosphate biosynthetic process
TM2_10880	COG2022	thiamine diphosphate biosynthetic process
TM2_10890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TM2_10900	COG0351	phosphomethylpyrimidine kinase
TM2_10910	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TM2_11020	COG0210	DNA helicase
TM2_11040	COG2153	protein acetylation
TM2_11050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TM2_11060	COG2382	esterase
TM2_11070	COG0626	cystathionine gamma-synthase activity
TM2_11080	COG0626	cystathionine gamma-synthase activity
TM2_11200	COG0825	malonyl-CoA metabolic process
TM2_11240	COG0457	Tetratricopeptide repeat
TM2_11310	COG3173	Aminoglycoside phosphotransferase
TM2_11320	COG0583	DNA-binding transcription factor activity
TM2_11360	COG0583	DNA-binding transcription factor activity
TM2_11370	COG2807	transmembrane transport
TM2_11420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TM2_11440	COG1309	transcriptional regulator
TM2_11460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM2_11470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM2_11510	COG4195	phage-related replication protein
TM2_11520	COG2856	Zn peptidase
TM2_11530	COG3409	Peptidoglycan-binding domain 1 protein
TM2_11530	COG5632	N-Acetylmuramoyl-L-alanine amidase
TM2_11560	COG0306	phosphate transporter
TM2_11570	COG1392	Phosphate transport regulator
TM2_11590	COG0405	Gamma-glutamyltransferase
TM2_11600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TM2_11620	COG4208	sulfate ABC transporter
TM2_11630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TM2_11650	COG3775	system Galactitol-specific IIC component
TM2_11680	COG1063	alcohol dehydrogenase
TM2_11690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TM2_11700	COG0022	dehydrogenase e1 component
TM2_11700	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_11720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TM2_11730	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_11740	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_11750	COG2390	Transcriptional regulator
TM2_11770	COG0531	amino acid
TM2_11780	COG0346	lactoylglutathione lyase activity
TM2_11790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TM2_11800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TM2_11810	COG2362	D-Aminopeptidase
TM2_11820	COG0601	transmembrane transport
TM2_11830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM2_11840	COG0444	Belongs to the ABC transporter superfamily
TM2_11850	COG4166	transmembrane transport
TM2_11860	COG1619	proteins homologs of microcin C7 resistance protein MccF
TM2_11870	COG4948	Mandelate Racemase Muconate Lactonizing
TM2_11880	COG0791	NLP P60 protein
TM2_11890	COG4608	Belongs to the ABC transporter superfamily
TM2_11900	COG1834	amidinotransferase
TM2_11910	COG1607	acyl-coa hydrolase
TM2_11920	COG1695	Transcriptional regulator
TM2_11950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TM2_11970	COG2076	Multidrug Resistance protein
TM2_11980	COG2076	Multidrug Resistance protein
TM2_12000	COG0788	formyltetrahydrofolate deformylase activity
TM2_12010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TM2_12020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TM2_12030	COG0457	Tetratricopeptide repeat
TM2_12050	COG1764	response to oxidative stress
TM2_12060	COG1846	Transcriptional regulator
TM2_12070	COG1764	response to oxidative stress
TM2_12080	COG0590	tRNA wobble adenosine to inosine editing
TM2_12090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TM2_12100	COG1404	Belongs to the peptidase S8 family
TM2_12130	COG0745	RESPONSE REGULATOR receiver
TM2_12140	COG5002	protein histidine kinase activity
TM2_12140	COG3850	Histidine kinase
TM2_12150	COG3212	peptidase
TM2_12160	COG3212	peptidase
TM2_12190	COG2239	Acts as a magnesium transporter
TM2_12210	COG0583	DNA-binding transcription factor activity
TM2_12240	COG0789	Transcriptional regulator
TM2_12270	COG1846	Transcriptional regulator
TM2_12280	COG5001	Diguanylate cyclase
TM2_12280	COG3300	MHYT domain
TM2_12290	COG0586	Pfam SNARE associated Golgi protein
TM2_12300	COG0861	Integral membrane protein TerC family
TM2_12310	COG1191	sigma factor activity
TM2_12350	COG0501	Belongs to the peptidase M48B family
TM2_12360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TM2_12370	COG2323	membrane
TM2_12400	COG3594	Acyltransferase
TM2_12410	COG5002	protein histidine kinase activity
TM2_12420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TM2_12440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TM2_12450	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
TM2_12460	COG0436	Aminotransferase
TM2_12470	COG1850	ribulose-bisphosphate carboxylase activity
TM2_12480	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
TM2_12490	COG0235	Class ii aldolase
TM2_12500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TM2_12520	COG3852	Histidine kinase
TM2_12530	COG1846	Transcriptional regulator
TM2_12540	COG1360	Flagellar Motor Protein
TM2_12550	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TM2_12560	COG0542	response to heat
TM2_12570	COG3949	Membrane
TM2_12580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TM2_12590	COG0720	synthase
TM2_12600	COG0602	queuosine metabolic process
TM2_12610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TM2_12630	COG4873	Protein conserved in bacteria
TM2_12650	COG3773	Cell wall hydrolase
TM2_12660	COG2244	polysaccharide biosynthetic process
TM2_12670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_12680	COG2217	Heavy metal translocating P-type atpase
TM2_12690	COG0006	proline dipeptidase activity
TM2_12710	COG1609	Transcriptional regulator
TM2_12720	COG3711	transcriptional antiterminator
TM2_12730	COG1263	PTS System
TM2_12730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_12730	COG2190	(PTS) system
TM2_12740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_12750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TM2_12770	COG1533	DNA photolyase activity
TM2_12780	COG0840	transmembrane signaling receptor activity
TM2_12800	COG2084	Dehydrogenase
TM2_12810	COG2340	Cysteine-rich secretory protein family
TM2_12820	COG0768	penicillin binding
TM2_12830	COG4191	Histidine kinase
TM2_12840	COG0436	Aminotransferase
TM2_12850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TM2_12870	COG1714	RDD family
TM2_12890	COG0835	chemotaxis
TM2_12890	COG0784	Response regulator, receiver
TM2_12910	COG1917	Cupin 2, conserved barrel domain protein
TM2_12910	COG2207	Transcriptional regulator
TM2_12920	COG0697	spore germination
TM2_12950	COG2814	Major facilitator Superfamily
TM2_12960	COG1376	ErfK ybiS ycfS ynhG family protein
TM2_12970	COG1408	metallophosphoesterase
TM2_12980	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_12990	COG2200	EAL domain
TM2_13000	COG3546	catalase activity
TM2_13010	COG4703	Protein of unknown function (DUF1797)
TM2_13020	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TM2_13040	COG0517	IMP dehydrogenase activity
TM2_13050	COG0583	DNA-binding transcription factor activity
TM2_13070	COG0716	FMN binding
TM2_13090	COG0716	FMN binding
TM2_13100	COG2171	N-acyltransferase activity
TM2_13110	COG1473	amidohydrolase
TM2_13130	COG0668	transmembrane transport
TM2_13140	COG0450	alkyl hydroperoxide reductase
TM2_13150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_13180	COG0746	molybdenum cofactor guanylyltransferase activity
TM2_13190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TM2_13200	COG0303	'Molybdopterin
TM2_13210	COG1763	Mo-molybdopterin cofactor biosynthetic process
TM2_13220	COG0314	molybdopterin synthase activity
TM2_13230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TM2_13260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TM2_13270	COG1136	(ABC) transporter
TM2_13280	COG0577	efflux transmembrane transporter activity
TM2_13290	COG1349	DNA-binding transcription factor activity
TM2_13300	COG1105	Belongs to the carbohydrate kinase PfkB family
TM2_13310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_13310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_13310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_13320	COG0681	Belongs to the peptidase S26 family
TM2_13340	COG0488	(ABC) transporter
TM2_13350	COG2309	aminopeptidase activity
TM2_13370	COG1077	Cell shape determining protein MreB Mrl
TM2_13380	COG2002	toxin-antitoxin pair type II binding
TM2_13390	COG3852	Histidine kinase
TM2_13400	COG2105	PFAM AIG2 family protein
TM2_13400	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
TM2_13410	COG0569	domain protein
TM2_13420	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TM2_13430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TM2_13440	COG5503	Protein of unknown function (DUF1447)
TM2_13450	COG0561	phosphatase activity
TM2_13460	COG0242	peptide deformylase activity
TM2_13490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TM2_13500	COG0022	dehydrogenase e1 component
TM2_13510	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_13520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TM2_13530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_13550	COG1982	Orn Lys Arg decarboxylase major
TM2_13560	COG4476	Belongs to the UPF0223 family
TM2_13570	COG4493	Belongs to the UPF0637 family
TM2_13590	COG0483	inositol monophosphate 1-phosphatase activity
TM2_13620	COG1595	DNA-templated transcription, initiation
TM2_13660	COG1217	gtp-binding protein TYPA
TM2_13680	COG4896	Protein conserved in bacteria
TM2_13700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TM2_13710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TM2_13720	COG2066	Belongs to the glutaminase family
TM2_13730	COG4838	Belongs to the UPF0358 family
TM2_13740	COG0772	Belongs to the SEDS family
TM2_13750	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TM2_13760	COG0415	Belongs to the DNA photolyase family
TM2_13770	COG1612	heme a metabolic process
TM2_13780	COG0109	protoheme IX farnesyltransferase activity
TM2_13790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TM2_13790	COG2010	Cytochrome c
TM2_13800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TM2_13810	COG1845	cytochrome c oxidase, subunit III
TM2_13820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TM2_13830	COG3336	cytochrome c oxidase
TM2_13850	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TM2_13860	COG2340	Cysteine-rich secretory protein family
TM2_13900	COG3679	Belongs to the UPF0342 family
TM2_13910	COG4471	UPF0298 protein
TM2_13920	COG0742	ribosomal rna small subunit methyltransferase
TM2_13930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TM2_13940	COG3314	Sporulation integral membrane protein YlbJ
TM2_13950	COG1752	Esterase of the alpha-beta hydrolase superfamily
TM2_13960	COG3480	Lon protease (S16) C-terminal proteolytic domain
TM2_13990	COG1399	metal-binding, possibly nucleic acid-binding protein
TM2_14000	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TM2_14020	COG0454	-acetyltransferase
TM2_14030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TM2_14040	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TM2_14050	COG2001	Belongs to the MraZ family
TM2_14060	COG0275	rRNA processing
TM2_14070	COG4839	cell division protein FtsL
TM2_14080	COG0768	penicillin binding
TM2_14090	COG0768	penicillin binding
TM2_14100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TM2_14110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TM2_14120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TM2_14130	COG0772	Belongs to the SEDS family
TM2_14140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TM2_14150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TM2_14160	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TM2_14170	COG3879	Bacterial protein of unknown function (DUF881)
TM2_14180	COG3879	Bacterial protein of unknown function (DUF881)
TM2_14190	COG3856	small basic protein
TM2_14200	COG0849	cell division
TM2_14210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TM2_14220	COG4412	M6 family metalloprotease domain protein
TM2_14220	COG1404	Belongs to the peptidase S8 family
TM2_14240	COG1191	sigma factor activity
TM2_14250	COG1191	sigma factor activity
TM2_14260	COG2390	Transcriptional regulator
TM2_14290	COG3730	PTS system glucitol sorbitol-specific
TM2_14300	COG3732	PTS system glucitol sorbitol-specific
TM2_14330	COG1119	ATPase activity
TM2_14340	COG1873	PFAM PRC-barrel domain
TM2_14350	COG1496	oxidoreductase activity
TM2_14360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TM2_14370	COG1799	cell septum assembly
TM2_14380	COG0762	integral membrane protein
TM2_14390	COG2302	S4 RNA-binding domain
TM2_14400	COG3599	regulation of cell shape
TM2_14410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TM2_14420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TM2_14430	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TM2_14440	COG0564	pseudouridine synthase activity
TM2_14450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TM2_14460	COG2233	PERMEase
TM2_14470	COG0540	Belongs to the ATCase OTCase family
TM2_14480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TM2_14490	COG0505	Belongs to the CarA family
TM2_14500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TM2_14510	COG0543	2 iron, 2 sulfur cluster binding
TM2_14520	COG0167	dihydroorotate dehydrogenase activity
TM2_14530	COG0284	orotidine-5'-phosphate decarboxylase activity
TM2_14540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TM2_14560	COG0175	sulfate reduction
TM2_14570	COG0306	phosphate transporter
TM2_14580	COG2046	Belongs to the sulfate adenylyltransferase family
TM2_14590	COG0529	Catalyzes the synthesis of activated sulfate
TM2_14600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TM2_14610	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
TM2_14620	COG1648	precorrin-2 dehydrogenase activity
TM2_14640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TM2_14650	COG1561	YicC-like family, N-terminal region
TM2_14660	COG2052	Domain of unknown function (DUF370)
TM2_14670	COG0194	GDP metabolic process
TM2_14680	COG1758	RNA polymerase activity
TM2_14690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TM2_14700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TM2_14710	COG0242	peptide deformylase activity
TM2_14720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TM2_14730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TM2_14730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TM2_14740	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TM2_14750	COG0631	protein serine/threonine phosphatase activity
TM2_14760	COG0515	serine threonine protein kinase
TM2_14760	COG2815	serine threonine protein kinase
TM2_14770	COG1162	GTPase activity
TM2_14780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TM2_14790	COG1564	THIamine pyrophosphokinase
TM2_14800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TM2_14810	COG1302	Protein conserved in bacteria
TM2_14820	COG1461	Dihydroxyacetone kinase
TM2_14830	COG1760	l-serine dehydratase
TM2_14840	COG1760	l-serine dehydratase
TM2_14850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TM2_14860	COG1349	DNA-binding transcription factor activity
TM2_14870	COG0416	fatty acid biosynthetic process
TM2_14880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TM2_14890	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_14900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TM2_14920	COG1196	nuclear chromosome segregation
TM2_14930	COG0552	protein localization to endoplasmic reticulum
TM2_14940	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
TM2_14950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TM2_14960	COG0228	four-way junction DNA binding
TM2_14970	COG1837	Belongs to the UPF0109 family
TM2_14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TM2_15000	COG0336	Belongs to the RNA methyltransferase TrmD family
TM2_15010	COG0335	large ribosomal subunit rRNA binding
TM2_15020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TM2_15030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TM2_15050	COG2257	FlhB HrpN YscU SpaS Family
TM2_15060	COG0045	succinate-CoA ligase (ADP-forming) activity
TM2_15070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TM2_15080	COG0758	DNA mediated transformation
TM2_15090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TM2_15100	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TM2_15110	COG4974	Belongs to the 'phage' integrase family
TM2_15120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TM2_15130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TM2_15140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TM2_15150	COG1815	bacterial-type flagellum-dependent cell motility
TM2_15160	COG1558	bacterial-type flagellum-dependent cell motility
TM2_15170	COG1677	Flagellar hook-basal body complex protein FliE
TM2_15180	COG1766	The M ring may be actively involved in energy transduction
TM2_15190	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TM2_15200	COG1317	bacterial-type flagellum organization
TM2_15210	COG1157	protein secretion by the type III secretion system
TM2_15220	COG2882	bacterial-type flagellum organization
TM2_15230	COG3334	PFAM MgtE intracellular
TM2_15240	COG3144	bacterial-type flagellum assembly
TM2_15250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TM2_15260	COG4786	Flagellar basal body rod
TM2_15270	COG1582	Flagellar protein (FlbD)
TM2_15280	COG1580	Controls the rotational direction of flagella during chemotaxis
TM2_15290	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TM2_15300	COG1776	CheC inhibitor of MCP methylation
TM2_15300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TM2_15310	COG2201	protein-glutamate methylesterase activity
TM2_15320	COG3190	flagellar
TM2_15330	COG1338	Plays a role in the flagellum-specific transport system
TM2_15340	COG1987	bacterial-type flagellum assembly
TM2_15350	COG1684	flagellar biosynthetic protein fliR
TM2_15360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TM2_15370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TM2_15380	COG1419	protein localization to endoplasmic reticulum
TM2_15390	COG0455	bacterial-type flagellum organization
TM2_15400	COG2201	protein-glutamate methylesterase activity
TM2_15410	COG0643	Histidine kinase
TM2_15410	COG2198	Histidine kinase
TM2_15420	COG0835	chemotaxis
TM2_15430	COG1776	CheC inhibitor of MCP methylation
TM2_15450	COG1191	sigma factor activity
TM2_15480	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TM2_15490	COG0528	UMP kinase activity
TM2_15500	COG0233	cytoplasmic translational termination
TM2_15510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TM2_15520	COG4589	Belongs to the CDS family
TM2_15530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TM2_15540	COG0750	zinc metalloprotease
TM2_15550	COG0442	prolyl-tRNA aminoacylation
TM2_15560	COG2176	DNA-directed DNA polymerase activity
TM2_15590	COG3693	PFAM glycoside hydrolase, family 10
TM2_15610	COG0779	Required for maturation of 30S ribosomal subunits
TM2_15620	COG0195	Participates in both transcription termination and antitermination
TM2_15630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TM2_15640	COG1358	cellular component organization or biogenesis
TM2_15650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TM2_15660	COG1550	Protein conserved in bacteria
TM2_15670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TM2_15680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TM2_15690	COG0196	riboflavin kinase activity
TM2_15700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TM2_15710	COG1185	polyribonucleotide nucleotidyltransferase activity
TM2_15720	COG0726	polysaccharide deacetylase
TM2_15730	COG0612	Peptidase, M16
TM2_15750	COG1873	PFAM PRC-barrel domain
TM2_15760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TM2_15770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TM2_15780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TM2_15790	COG0527	aspartate kinase activity
TM2_15810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TM2_15820	COG0740	serine-type endopeptidase activity
TM2_15840	COG1674	ftsk spoiiie
TM2_15840	COG4980	gas vesicle protein
TM2_15850	COG2188	Transcriptional regulator
TM2_15860	COG2814	Major facilitator Superfamily
TM2_15870	COG1033	growth of symbiont in host cell
TM2_15870	COG2409	Drug exporters of the RND superfamily
TM2_15880	COG0612	Peptidase, M16
TM2_15890	COG0612	Peptidase, M16
TM2_15910	COG2409	Drug exporters of the RND superfamily
TM2_15910	COG1033	growth of symbiont in host cell
TM2_15920	COG0300	oxidoreductase activity
TM2_15950	COG1426	Protein conserved in bacteria
TM2_15960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TM2_15970	COG1058	Belongs to the CinA family
TM2_15970	COG1546	Belongs to the CinA family
TM2_15980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TM2_15990	COG1418	mRNA catabolic process
TM2_16000	COG1692	metallophosphoesterase
TM2_16010	COG2359	stage V sporulation protein S
TM2_16020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TM2_16030	COG1063	alcohol dehydrogenase
TM2_16040	COG0156	8-amino-7-oxononanoate synthase activity
TM2_16050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM2_16060	COG4550	Control of competence regulator ComK, YlbF/YmcA
TM2_16090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TM2_16100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TM2_16140	COG1329	Transcriptional regulator
TM2_16150	COG4195	phage-related replication protein
TM2_16160	COG0457	Tetratricopeptide repeat
TM2_16170	COG1404	Belongs to the peptidase S8 family
TM2_16180	COG4195	phage-related replication protein
TM2_16190	COG1764	response to oxidative stress
TM2_16200	COG2076	Multidrug Resistance protein
TM2_16250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TM2_16260	COG1923	regulation of RNA biosynthetic process
TM2_16290	COG1780	Probably involved in ribonucleotide reductase function
TM2_16300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TM2_16310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TM2_16320	COG4112	unkown
TM2_16340	COG0464	growth
TM2_16350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TM2_16360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TM2_16370	COG0789	Transcriptional regulator
TM2_16380	COG0174	glutamine synthetase
TM2_16420	COG0457	Tetratricopeptide repeat
TM2_16460	COG0604	alcohol dehydrogenase
TM2_16480	COG5444	nuclease activity
TM2_16520	COG5646	InterPro IPR014922
TM2_16570	COG0457	Tetratricopeptide repeat
TM2_16590	COG3619	membrane
TM2_16600	COG1793	dna ligase
TM2_16600	COG3285	dna ligase
TM2_16610	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TM2_16620	COG4876	unkown
TM2_16640	COG1959	2 iron, 2 sulfur cluster binding
TM2_16650	COG0702	epimerase
TM2_16660	COG0247	lactate metabolic process
TM2_16670	COG1139	Iron-sulfur cluster binding protein
TM2_16680	COG1556	Lactate utilization protein
TM2_16720	COG2323	membrane
TM2_16730	COG1309	transcriptional regulator
TM2_16740	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TM2_16740	COG2124	cytochrome p450
TM2_16750	COG3591	Belongs to the peptidase S1B family
TM2_16760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TM2_16770	COG3209	COG3209 Rhs family protein
TM2_16780	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_16810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TM2_16820	COG1388	LysM domain
TM2_16830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TM2_16840	COG4224	UPF0291 protein
TM2_16850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TM2_16870	COG3763	UPF0154 protein
TM2_16880	COG0785	Cytochrome C biogenesis protein
TM2_16890	COG4846	Membrane protein involved in cytochrome C biogenesis
TM2_16910	COG0071	Belongs to the small heat shock protein (HSP20) family
TM2_16940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TM2_16950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_16990	COG0824	Thioesterase
TM2_17010	COG4841	protein insertion into membrane
TM2_17020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TM2_17030	COG1832	CoA-binding protein
TM2_17040	COG0187	DNA topoisomerase II activity
TM2_17050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TM2_17080	COG0738	Major facilitator superfamily
TM2_17090	COG0473	3-isopropylmalate dehydrogenase activity
TM2_17100	COG0110	maltose O-acetyltransferase activity
TM2_17110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TM2_17120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TM2_17130	COG0640	Transcriptional regulator
TM2_17160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TM2_17170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TM2_17190	COG1309	transcriptional regulator
TM2_17200	COG2249	NAD(P)H dehydrogenase (quinone) activity
TM2_17210	COG1733	regulation of RNA biosynthetic process
TM2_17230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TM2_17240	COG0251	oxidation-reduction process
TM2_17310	COG0657	acetylesterase activity
TM2_17340	COG2205	protein histidine kinase activity
TM2_17350	COG0745	RESPONSE REGULATOR receiver
TM2_17370	COG3507	Belongs to the glycosyl hydrolase 43 family
TM2_17380	COG1012	belongs to the aldehyde dehydrogenase family
TM2_17390	COG1486	melibiose metabolic process
TM2_17400	COG0395	ABC-type sugar transport system, permease component
TM2_17410	COG1175	transmembrane transport
TM2_17420	COG1653	transport
TM2_17430	COG1609	Transcriptional regulator
TM2_17440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TM2_17470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_17490	COG0456	acetyltransferase
TM2_17500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_17520	COG1846	Transcriptional regulator
TM2_17530	COG2814	Major facilitator Superfamily
TM2_17550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_17550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_17550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_17560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_17560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TM2_17560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_17570	COG1105	Belongs to the carbohydrate kinase PfkB family
TM2_17590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TM2_17630	COG1012	belongs to the aldehyde dehydrogenase family
TM2_17640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
TM2_17650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TM2_17660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TM2_17670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TM2_17680	COG1024	Enoyl-CoA hydratase
TM2_17690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TM2_17700	COG0511	ligase activity, forming carbon-carbon bonds
TM2_17710	COG0439	Biotin carboxylase
TM2_17720	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_17730	COG1960	acyl-CoA dehydrogenase activity
TM2_17740	COG1649	PFAM Uncharacterised BCR, COG1649
TM2_17750	COG2365	Tyrosine phosphatase family
TM2_17760	COG1349	DNA-binding transcription factor activity
TM2_17770	COG1942	4-Oxalocrotonate Tautomerase
TM2_17790	COG3835	regulator
TM2_17800	COG0277	FAD linked oxidase domain protein
TM2_17810	COG0247	lactate metabolic process
TM2_17850	COG0166	Belongs to the GPI family
TM2_17860	COG2246	polysaccharide biosynthetic process
TM2_17870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TM2_17880	COG0586	Pfam SNARE associated Golgi protein
TM2_17890	COG1587	Uroporphyrinogen-III synthase
TM2_17910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_17950	COG0534	Mate efflux family protein
TM2_17960	COG2027	D-alanyl-D-alanine carboxypeptidase
TM2_17970	COG4677	pectinesterase activity
TM2_17980	COG2323	membrane
TM2_17990	COG2146	nitrite reductase [NAD(P)H] activity
TM2_18000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TM2_18010	COG0243	molybdopterin cofactor binding
TM2_18020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TM2_18030	COG2223	nitrite transmembrane transporter activity
TM2_18040	COG0493	'glutamate synthase
TM2_18050	COG0067	glutamate synthase
TM2_18050	COG0069	glutamate synthase activity
TM2_18050	COG0070	glutamate synthase
TM2_18060	COG0583	DNA-binding transcription factor activity
TM2_18080	COG1132	(ABC) transporter
TM2_18090	COG0789	Transcriptional regulator
TM2_18090	COG4978	Transcriptional regulator
TM2_18100	COG0454	-acetyltransferase
TM2_18110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TM2_18120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TM2_18130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TM2_18150	COG0243	molybdopterin cofactor binding
TM2_18170	COG1070	Carbohydrate kinase
TM2_18180	COG2115	Belongs to the xylose isomerase family
TM2_18190	COG1940	carbohydrate kinase activity
TM2_18210	COG2211	Major facilitator Superfamily
TM2_18220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM2_18230	COG1994	Peptidase M50
TM2_18270	COG1309	transcriptional regulator
TM2_18280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_18290	COG3708	Transcriptional regulator
TM2_18300	COG2378	regulation of single-species biofilm formation
TM2_18320	COG0640	Transcriptional regulator
TM2_18330	COG0531	amino acid
TM2_18340	COG0741	lytic transglycosylase activity
TM2_18350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TM2_18360	COG2079	MmgE PrpD family protein
TM2_18370	COG0372	Belongs to the citrate synthase family
TM2_18380	COG2322	membrane
TM2_18400	COG1388	LysM domain
TM2_18400	COG3584	3D domain protein
TM2_18410	COG0514	ATP-dependent DNA helicase (RecQ)
TM2_18430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TM2_18480	COG1012	belongs to the aldehyde dehydrogenase family
TM2_18490	COG1657	PFAM Prenyltransferase squalene oxidase
TM2_18500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TM2_18510	COG0385	Bile acid
TM2_18520	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_18530	COG0567	Dehydrogenase, E1 component
TM2_18540	COG4548	von Willebrand factor, type A
TM2_18550	COG0714	Associated with various cellular activities
TM2_18560	COG2032	superoxide dismutase activity
TM2_18570	COG0791	NLP P60 protein
TM2_18570	COG1388	LysM domain
TM2_18580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TM2_18600	COG0534	Mate efflux family protein
TM2_18610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TM2_18620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TM2_18640	COG2962	Rard protein
TM2_18670	COG1733	regulation of RNA biosynthetic process
TM2_18680	COG0778	Nitroreductase
TM2_18700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TM2_18710	COG0793	Belongs to the peptidase S41A family
TM2_18710	COG3409	Peptidoglycan-binding domain 1 protein
TM2_18720	COG2226	methyltransferase
TM2_18740	COG1876	peptidase activity
TM2_18750	COG0813	purine-nucleoside phosphorylase activity
TM2_18770	COG0671	phosphoesterase, PA-phosphatase related
TM2_18810	COG4479	Belongs to the UPF0346 family
TM2_18830	COG1509	lysine 2,3-aminomutase activity
TM2_18840	COG3829	transcription factor binding
TM2_18850	COG0463	Glycosyl transferase, family 2
TM2_18880	COG4641	Protein conserved in bacteria
TM2_18900	COG1086	Polysaccharide biosynthesis protein
TM2_18910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TM2_18920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TM2_18930	COG1846	Transcriptional regulator
TM2_18970	COG4698	Protein conserved in bacteria
TM2_18980	COG2755	lipolytic protein G-D-S-L family
TM2_18990	COG1999	signal sequence binding
TM2_19020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TM2_19030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TM2_19040	COG1272	protein, Hemolysin III
TM2_19050	COG0204	Acyl-transferase
TM2_19060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TM2_19070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
TM2_19080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TM2_19100	COG2136	Putative SAM-dependent methyltransferase
TM2_19100	COG2521	methyltransferase
TM2_19120	COG0129	dihydroxy-acid dehydratase activity
TM2_19130	COG1413	lyase activity
TM2_19140	COG1418	mRNA catabolic process
TM2_19150	COG0386	Belongs to the glutathione peroxidase family
TM2_19160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TM2_19170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TM2_19180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TM2_19200	COG1278	Cold shock
TM2_19230	COG0328	RNA-DNA hybrid ribonuclease activity
TM2_19240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TM2_19250	COG0328	RNA-DNA hybrid ribonuclease activity
TM2_19260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TM2_19290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TM2_19300	COG1755	Isoprenylcysteine carboxyl methyltransferase
TM2_19310	COG3424	synthase
TM2_19320	COG0456	acetyltransferase
TM2_19320	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TM2_19330	COG0726	polysaccharide deacetylase
TM2_19340	COG2233	PERMEase
TM2_19350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TM2_19360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TM2_19370	COG1199	ATP-dependent helicase activity
TM2_19390	COG0116	Belongs to the methyltransferase superfamily
TM2_19400	COG3599	regulation of cell shape
TM2_19410	COG4474	Belongs to the UPF0398 family
TM2_19420	COG3359	exonuclease
TM2_19430	COG1111	helicase
TM2_19430	COG1205	dead DEAH box helicase
TM2_19440	COG1902	pentaerythritol trinitrate reductase activity
TM2_19450	COG2190	(PTS) system
TM2_19460	COG0071	Belongs to the small heat shock protein (HSP20) family
TM2_19510	COG3331	DNA recombination
TM2_19520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TM2_19520	COG4499	WXG100 protein secretion system (Wss), protein YukC
TM2_19540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TM2_19550	COG3935	DnaD domain protein
TM2_19560	COG0017	Asparaginyl-tRNA synthetase
TM2_19570	COG5353	protein conserved in bacteria
TM2_19590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TM2_19590	COG1199	ATP-dependent helicase activity
TM2_19600	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TM2_19610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TM2_19620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TM2_19640	COG0617	tRNA 3'-terminal CCA addition
TM2_19650	COG0438	transferase activity, transferring glycosyl groups
TM2_19660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TM2_19670	COG1803	Methylglyoxal synthase
TM2_19680	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TM2_19690	COG1694	Mazg nucleotide pyrophosphohydrolase
TM2_19700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM2_19720	COG4347	Protein of unknown function (DUF1405)
TM2_19730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TM2_19730	COG2010	Cytochrome c
TM2_19740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TM2_19750	COG0723	plastoquinol--plastocyanin reductase activity
TM2_19770	COG5582	Belongs to the UPF0302 family
TM2_19780	COG0457	Tetratricopeptide repeat
TM2_19790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TM2_19800	COG0287	Prephenate dehydrogenase
TM2_19810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TM2_19820	COG0159	tryptophan synthase activity
TM2_19830	COG0133	tryptophan synthase activity
TM2_19840	COG0135	phosphoribosylanthranilate isomerase activity
TM2_19850	COG0134	indole-3-glycerol-phosphate synthase activity
TM2_19860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TM2_19880	COG4401	Chorismate mutase type I
TM2_19890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TM2_19900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TM2_19910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TM2_19930	COG0105	UTP biosynthetic process
TM2_19940	COG0142	geranyltranstransferase activity
TM2_19950	COG2226	methyltransferase
TM2_19960	COG0142	geranyltranstransferase activity
TM2_19980	COG0302	gtp cyclohydrolase
TM2_19990	COG0776	regulation of translation
TM2_20000	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TM2_20030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TM2_20040	COG1160	GTP binding
TM2_20090	COG1304	FMN binding
TM2_20100	COG0539	negative regulation of cytoplasmic translation
TM2_20110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TM2_20130	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
TM2_20140	COG2959	enzyme of heme biosynthesis
TM2_20150	COG3773	Cell wall hydrolase
TM2_20150	COG3409	Peptidoglycan-binding domain 1 protein
TM2_20160	COG2339	peptidase activity
TM2_20170	COG0492	ferredoxin-NADP+ reductase activity
TM2_20180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TM2_20190	COG4862	establishment of competence for transformation
TM2_20200	COG1408	metallophosphoesterase
TM2_20220	COG1388	LysM domain
TM2_20230	COG1266	CAAX protease self-immunity
TM2_20240	COG0514	ATP-dependent DNA helicase (RecQ)
TM2_20250	COG4955	Helix-turn-helix domain
TM2_20260	COG1141	Ferredoxin
TM2_20270	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TM2_20280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TM2_20310	COG1595	DNA-templated transcription, initiation
TM2_20320	COG5002	protein histidine kinase activity
TM2_20330	COG0745	RESPONSE REGULATOR receiver
TM2_20340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TM2_20350	COG1333	cytochrome c biogenesis protein
TM2_20360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_20370	COG1187	pseudouridine synthase activity
TM2_20380	COG0700	Nucleoside recognition
TM2_20390	COG2715	membrane protein required for spore maturation
TM2_20400	COG1686	Belongs to the peptidase S11 family
TM2_20420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TM2_20430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TM2_20440	COG1547	Domain of unknown function (DUF309)
TM2_20450	COG0456	acetyltransferase
TM2_20460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TM2_20470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_20470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_20480	COG0307	riboflavin synthase, alpha
TM2_20520	COG2814	Major facilitator Superfamily
TM2_20530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TM2_20540	COG4086	secreted protein
TM2_20550	COG0019	diaminopimelate decarboxylase activity
TM2_20560	COG0697	spore germination
TM2_20590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TM2_20630	COG1191	sigma factor activity
TM2_20640	COG2172	sigma factor antagonist activity
TM2_20660	COG1686	Belongs to the peptidase S11 family
TM2_20670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TM2_20680	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TM2_20690	COG4974	Belongs to the 'phage' integrase family
TM2_20710	COG0735	belongs to the Fur family
TM2_20720	COG1300	Membrane
TM2_20730	COG1404	Belongs to the peptidase S8 family
TM2_20750	COG2153	protein acetylation
TM2_20760	COG1379	DNA repair
TM2_20770	COG0494	nUDIX hydrolase
TM2_20780	COG0667	Aldo Keto reductase
TM2_20820	COG1073	alpha beta
TM2_20830	COG0457	Tetratricopeptide repeat
TM2_20850	COG4918	Iron-sulphur cluster biosynthesis
TM2_20860	COG4305	rare lipoprotein A
TM2_20870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TM2_20870	COG0456	acetyltransferase
TM2_20880	COG0456	acetyltransferase
TM2_20900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TM2_20920	COG2211	Major facilitator Superfamily
TM2_20930	COG1072	(Pantothenic acid kinase))
TM2_20940	COG0446	pyridine nucleotide-disulphide oxidoreductase
TM2_20960	COG0300	oxidoreductase activity
TM2_20970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_20980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TM2_21000	COG4187	Peptidase family M20/M25/M40
TM2_21010	COG1902	pentaerythritol trinitrate reductase activity
TM2_21020	COG0596	Alpha beta hydrolase
TM2_21030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM2_21050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TM2_21060	COG2188	Transcriptional regulator
TM2_21070	COG2723	6-phospho-beta-galactosidase activity
TM2_21080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_21090	COG1447	Phosphotransferase system cellobiose-specific component IIA
TM2_21100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_21110	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_21130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TM2_21140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TM2_21160	COG0706	membrane insertase activity
TM2_21170	COG0835	chemotaxis
TM2_21180	COG2195	Cleaves the N-terminal amino acid of tripeptides
TM2_21190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TM2_21200	COG0346	lactoylglutathione lyase activity
TM2_21210	COG1376	ErfK ybiS ycfS ynhG family protein
TM2_21220	COG4129	membrane
TM2_21230	COG1126	abc transporter atp-binding protein
TM2_21240	COG0765	amino acid transport
TM2_21250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_21270	COG1597	lipid kinase activity
TM2_21290	COG0508	dehydrogenase complex catalyzes the overall conversion of
TM2_21300	COG0022	dehydrogenase e1 component
TM2_21310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TM2_21320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TM2_21330	COG3426	butyrate kinase activity
TM2_21340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TM2_21350	COG0280	phosphate acetyltransferase
TM2_21360	COG3290	protein histidine kinase activity
TM2_21360	COG3829	transcription factor binding
TM2_21380	COG0584	glycerophosphoryl diester phosphodiesterase
TM2_21390	COG0457	Tetratricopeptide repeat
TM2_21400	COG0745	RESPONSE REGULATOR receiver
TM2_21410	COG0750	zinc metalloprotease
TM2_21420	COG0497	DNA recombination
TM2_21430	COG1438	arginine binding
TM2_21440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TM2_21450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TM2_21460	COG0142	geranyltranstransferase activity
TM2_21470	COG1722	exodeoxyribonuclease VII activity
TM2_21480	COG1570	exodeoxyribonuclease VII activity
TM2_21490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TM2_21500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TM2_21510	COG1302	Protein conserved in bacteria
TM2_21520	COG0439	Biotin carboxylase
TM2_21530	COG0511	ligase activity, forming carbon-carbon bonds
TM2_21610	COG3854	ATPases associated with a variety of cellular activities
TM2_21630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TM2_21640	COG0006	proline dipeptidase activity
TM2_21650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TM2_21670	COG3872	metal-dependent enzyme
TM2_21690	COG1752	Esterase of the alpha-beta hydrolase superfamily
TM2_21700	COG1321	iron dependent repressor
TM2_21710	COG0095	Lipoate-protein ligase
TM2_21720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TM2_21730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TM2_21740	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TM2_21750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TM2_21760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TM2_21810	COG0681	Belongs to the peptidase S26 family
TM2_21880	COG4970	Tfp pilus assembly protein FimT
TM2_21890	COG4537	Required for transformation and DNA binding
TM2_21900	COG1459	type II secretion system
TM2_21910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TM2_21930	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_21940	COG1393	Belongs to the ArsC family
TM2_21960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_21980	COG0011	TIGRFAM Protein of
TM2_21990	COG2814	Major facilitator Superfamily
TM2_22000	COG2866	Carboxypeptidase
TM2_22010	COG1368	sulfuric ester hydrolase activity
TM2_22020	COG1940	carbohydrate kinase activity
TM2_22030	COG4483	Protein conserved in bacteria
TM2_22040	COG0457	Tetratricopeptide repeat
TM2_22040	COG0705	Rhomboid family
TM2_22070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TM2_22080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TM2_22110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TM2_22120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TM2_22130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TM2_22140	COG0581	inorganic phosphate transmembrane transporter activity
TM2_22150	COG0573	inorganic phosphate transmembrane transporter activity
TM2_22160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TM2_22170	COG0768	penicillin binding
TM2_22180	COG0477	Major facilitator Superfamily
TM2_22190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TM2_22200	COG2839	Protein conserved in bacteria
TM2_22210	COG5521	maltodextrose utilization protein MalA
TM2_22220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TM2_22230	COG1388	LysM domain
TM2_22240	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TM2_22250	COG4709	membrane
TM2_22260	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
TM2_22270	COG1940	carbohydrate kinase activity
TM2_22280	COG0735	belongs to the Fur family
TM2_22290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TM2_22300	COG1121	(ABC) transporter
TM2_22310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM2_22340	COG0513	Belongs to the DEAD box helicase family
TM2_22360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TM2_22370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TM2_22380	COG2384	SAM-dependent methyltransferase
TM2_22390	COG2010	Cytochrome c
TM2_22400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TM2_22410	COG0358	DNA primase activity
TM2_22420	COG1671	Belongs to the UPF0178 family
TM2_22430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TM2_22440	COG0517	IMP dehydrogenase activity
TM2_22450	COG0751	glycine-tRNA ligase activity
TM2_22460	COG0752	glycyl-tRNA synthetase alpha subunit
TM2_22470	COG1381	Involved in DNA repair and RecF pathway recombination
TM2_22490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TM2_22500	COG0295	cytidine deaminase activity
TM2_22510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TM2_22520	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TM2_22530	COG1480	7TM receptor with intracellular HD hydrolase
TM2_22540	COG1702	phosphate starvation-inducible protein PhoH
TM2_22550	COG0561	phosphatase activity
TM2_22580	COG4864	UPF0365 protein
TM2_22590	COG1030	water channel activity
TM2_22600	COG1610	YqeY-like protein
TM2_22620	COG1283	sodium-dependent phosphate transmembrane transporter activity
TM2_22630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM2_22640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TM2_22650	COG2264	protein methyltransferase activity
TM2_22660	COG0484	heat shock protein binding
TM2_22670	COG0443	Heat shock 70 kDa protein
TM2_22680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TM2_22690	COG1420	regulation of RNA biosynthetic process
TM2_22700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TM2_22710	COG0481	GTPase activity
TM2_22730	COG0860	N-Acetylmuramoyl-L-alanine amidase
TM2_22740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TM2_22750	COG0268	Binds directly to 16S ribosomal RNA
TM2_22760	COG1466	dna polymerase III delta subunit
TM2_22780	COG0658	competence protein
TM2_22780	COG2333	competence protein COMEC
TM2_22790	COG0658	competence protein
TM2_22790	COG2333	competence protein COMEC
TM2_22800	COG2131	deaminase
TM2_22810	COG1596	polysaccharide export
TM2_22810	COG1555	photosystem II stabilization
TM2_22820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TM2_22830	COG2226	methyltransferase
TM2_22840	COG0799	negative regulation of ribosome biogenesis
TM2_22850	COG1713	HD superfamily hydrolase involved in NAD metabolism
TM2_22860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TM2_22870	COG1534	Rna-binding protein
TM2_22880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TM2_22890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TM2_22900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TM2_22920	COG2755	lipolytic protein G-D-S-L family
TM2_22940	COG0457	Tetratricopeptide repeat
TM2_22990	COG0726	polysaccharide deacetylase
TM2_23060	COG1131	(ABC) transporter
TM2_23110	COG2160	L-arabinose isomerase activity
TM2_23150	COG1609	Transcriptional regulator
TM2_23170	COG1846	Transcriptional regulator
TM2_23190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TM2_23200	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TM2_23210	COG1733	regulation of RNA biosynthetic process
TM2_23220	COG0657	acetylesterase activity
TM2_23340	COG2602	Beta-lactamase
TM2_23350	COG1960	acyl-CoA dehydrogenase activity
TM2_23360	COG1126	abc transporter atp-binding protein
TM2_23370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_23380	COG0765	amino acid transport
TM2_23400	COG3546	catalase activity
TM2_23410	COG1063	alcohol dehydrogenase
TM2_23430	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_23450	COG1115	amino acid carrier protein
TM2_23460	COG0583	DNA-binding transcription factor activity
TM2_23470	COG0842	Transport permease protein
TM2_23480	COG1511	domain protein
TM2_23480	COG0842	Transport permease protein
TM2_23500	COG1131	(ABC) transporter
TM2_23510	COG1063	alcohol dehydrogenase
TM2_23520	COG2226	methyltransferase
TM2_23570	COG0626	cystathionine gamma-synthase activity
TM2_23580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TM2_23590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TM2_23600	COG2226	methyltransferase
TM2_23630	COG0768	penicillin binding
TM2_23640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TM2_23650	COG0572	uridine kinase
TM2_23660	COG0826	peptidase U32
TM2_23670	COG0826	peptidase U32
TM2_23680	COG4122	O-methyltransferase activity
TM2_23690	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TM2_23700	COG0183	Belongs to the thiolase family
TM2_23710	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_23720	COG1268	BioY protein
TM2_23730	COG3906	Belongs to the UPF0473 family
TM2_23740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TM2_23750	COG4472	Bacterial protein of unknown function (DUF965)
TM2_23760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TM2_23770	COG0628	permease
TM2_23780	COG1126	abc transporter atp-binding protein
TM2_23790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_23800	COG0765	amino acid transport
TM2_23810	COG0765	amino acid transport
TM2_23840	COG3881	PFAM PRC-barrel domain
TM2_23850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TM2_23860	COG0457	Tetratricopeptide repeat
TM2_23870	COG0482	sulfurtransferase activity
TM2_23880	COG1104	cysteine desulfurase activity
TM2_23890	COG1959	2 iron, 2 sulfur cluster binding
TM2_23900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TM2_23910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TM2_23930	COG0124	histidyl-tRNA synthetase
TM2_23950	COG4991	sh3 domain protein
TM2_23950	COG0860	N-Acetylmuramoyl-L-alanine amidase
TM2_23950	COG3103	Sh3 type 3 domain protein
TM2_23960	COG1490	D-aminoacyl-tRNA deacylase activity
TM2_23970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TM2_23980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TM2_23990	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TM2_23990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TM2_24000	COG5416	Lipopolysaccharide assembly protein A domain
TM2_24010	COG0490	domain, Protein
TM2_24020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TM2_24020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TM2_24040	COG2244	polysaccharide biosynthetic process
TM2_24050	COG2323	membrane
TM2_24070	COG1862	Preprotein translocase
TM2_24080	COG0343	queuine tRNA-ribosyltransferase activity
TM2_24090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TM2_24110	COG2255	four-way junction helicase activity
TM2_24120	COG0632	four-way junction helicase activity
TM2_24140	COG2112	serine threonine protein kinase
TM2_24170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TM2_24200	COG1388	LysM domain
TM2_24210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TM2_24220	COG0157	Belongs to the NadC ModD family
TM2_24230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TM2_24240	COG1104	cysteine desulfurase activity
TM2_24250	COG1827	regulation of RNA biosynthetic process
TM2_24260	COG0077	Prephenate dehydratase
TM2_24270	COG4492	Belongs to the UPF0735 family
TM2_24280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TM2_24290	COG3290	protein histidine kinase activity
TM2_24300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TM2_24310	COG2868	ribosomal protein
TM2_24320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TM2_24330	COG1994	Peptidase M50
TM2_24340	COG0739	heme binding
TM2_24350	COG2894	cell division
TM2_24360	COG0850	regulation of cytokinetic process
TM2_24370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
TM2_24390	COG1077	Cell shape determining protein MreB Mrl
TM2_24400	COG2003	Belongs to the UPF0758 family
TM2_24410	COG0424	maF-like protein
TM2_24440	COG0285	dihydrofolate synthase activity
TM2_24450	COG0525	valine-tRNA ligase activity
TM2_24470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TM2_24480	COG1388	LysM domain
TM2_24490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TM2_24500	COG0113	porphobilinogen synthase activity
TM2_24510	COG1587	Uroporphyrinogen-III synthase
TM2_24520	COG0181	hydroxymethylbilane synthase activity
TM2_24530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TM2_24540	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TM2_24590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TM2_24600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TM2_24610	COG0470	DNA polymerase III
TM2_24610	COG1067	ATP-dependent peptidase activity
TM2_24620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TM2_24630	COG0544	peptidyl-prolyl cis-trans isomerase activity
TM2_24640	COG0457	Tetratricopeptide repeat
TM2_24640	COG1477	protein flavinylation
TM2_24650	COG0066	3-isopropylmalate dehydratase activity
TM2_24660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TM2_24670	COG0473	3-isopropylmalate dehydrogenase activity
TM2_24680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TM2_24690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TM2_24700	COG0440	acetolactate synthase activity
TM2_24710	COG0028	Belongs to the TPP enzyme family
TM2_24720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TM2_24730	COG2706	6-phosphogluconolactonase activity
TM2_24740	COG3339	Conserved Protein
TM2_24750	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
TM2_24760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TM2_24770	COG1696	Membrane protein involved in D-alanine export
TM2_24880	COG0582	viral genome integration into host DNA
TM2_24910	COG0622	Phosphoesterase
TM2_24920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TM2_24930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TM2_24940	COG5401	PFAM Sporulation and spore germination
TM2_24950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TM2_24960	COG1846	Transcriptional regulator
TM2_24970	COG2197	response regulator
TM2_24980	COG2851	Citrate transporter
TM2_24990	COG0583	DNA-binding transcription factor activity
TM2_25000	COG2828	Protein conserved in bacteria
TM2_25020	COG0824	Thioesterase
TM2_25030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TM2_25040	COG1053	succinate dehydrogenase
TM2_25050	COG2009	succinate dehydrogenase
TM2_25060	COG1719	4-vinyl reductase, 4VR
TM2_25070	COG0527	aspartate kinase activity
TM2_25080	COG0322	excinuclease ABC activity
TM2_25090	COG3118	belongs to the thioredoxin family
TM2_25100	COG3534	alpha-L-arabinofuranosidase
TM2_25110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TM2_25120	COG2086	electron transfer activity
TM2_25130	COG1024	Enoyl-CoA hydratase
TM2_25140	COG1309	transcriptional regulator
TM2_25150	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_25170	COG3766	membrane
TM2_25180	COG1193	negative regulation of DNA recombination
TM2_25190	COG1796	DNA polymerase
TM2_25190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TM2_25200	COG1286	toxin biosynthetic process
TM2_25210	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TM2_25220	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TM2_25230	COG0072	phenylalanine-tRNA ligase activity
TM2_25230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM2_25240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TM2_25250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TM2_25270	COG1966	Carbon starvation protein
TM2_25280	COG1363	Peptidase, m42
TM2_25300	COG3326	Membrane
TM2_25310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TM2_25320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TM2_25330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TM2_25350	COG1011	Hydrolase
TM2_25370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TM2_25390	COG0398	Pfam SNARE associated Golgi protein
TM2_25400	COG1484	DNA-dependent DNA replication
TM2_25410	COG3611	Membrane attachment protein
TM2_25420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TM2_25440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TM2_25450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TM2_25460	COG0237	dephospho-CoA kinase activity
TM2_25470	COG1971	Probably functions as a manganese efflux pump
TM2_25480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TM2_25490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TM2_25490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TM2_25500	COG5002	protein histidine kinase activity
TM2_25510	COG0745	RESPONSE REGULATOR receiver
TM2_25520	COG0039	L-malate dehydrogenase activity
TM2_25530	COG0538	isocitrate dehydrogenase activity
TM2_25540	COG0372	Belongs to the citrate synthase family
TM2_25550	COG2707	UPF0756 membrane protein
TM2_25560	COG0628	permease
TM2_25570	COG3030	protein affecting phage T7 exclusion by the F plasmid
TM2_25590	COG0205	6-phosphofructokinase activity
TM2_25600	COG0825	malonyl-CoA metabolic process
TM2_25610	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TM2_25620	COG0281	malic enzyme
TM2_25630	COG0587	DNA-directed DNA polymerase activity
TM2_25670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TM2_25690	COG4109	DRTGG domain
TM2_25700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TM2_25710	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_25730	COG0165	Argininosuccinate lyase
TM2_25740	COG0137	argininosuccinate synthase activity
TM2_25750	COG0521	Mo-molybdopterin cofactor biosynthetic process
TM2_25760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TM2_25770	COG0827	DNA restriction-modification system
TM2_25780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TM2_25790	COG3874	Sporulation protein YtfJ
TM2_25810	COG1714	RDD family
TM2_25820	COG0616	signal peptide processing
TM2_25830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TM2_25850	COG3239	Fatty acid desaturase
TM2_25860	COG4585	Histidine kinase
TM2_25870	COG2197	response regulator
TM2_25880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_25890	COG0745	RESPONSE REGULATOR receiver
TM2_25900	COG2205	protein histidine kinase activity
TM2_25910	COG1136	(ABC) transporter
TM2_25920	COG0577	efflux transmembrane transporter activity
TM2_25930	COG0402	S-adenosylhomocysteine deaminase activity
TM2_25940	COG2249	NAD(P)H dehydrogenase (quinone) activity
TM2_25990	COG1279	arginine transmembrane transporter activity
TM2_26000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TM2_26020	COG0301	tRNA thio-modification
TM2_26030	COG1104	cysteine desulfurase activity
TM2_26040	COG1114	Component of the transport system for branched-chain amino acids
TM2_26050	COG1114	Component of the transport system for branched-chain amino acids
TM2_26060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
TM2_26070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TM2_26080	COG1309	transcriptional regulator
TM2_26090	COG1956	GAF domain-containing protein
TM2_26100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TM2_26120	COG1335	isochorismatase
TM2_26140	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TM2_26150	COG2329	Antibiotic biosynthesis monooxygenase
TM2_26160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TM2_26170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TM2_26180	COG0454	-acetyltransferase
TM2_26190	COG0517	IMP dehydrogenase activity
TM2_26200	COG0123	including yeast histone deacetylase and acetoin utilization protein
TM2_26210	COG1609	Transcriptional regulator
TM2_26220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TM2_26220	COG1605	Chorismate mutase
TM2_26230	COG3118	belongs to the thioredoxin family
TM2_26240	COG4980	gas vesicle protein
TM2_26250	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
TM2_26260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TM2_26270	COG1674	ftsk spoiiie
TM2_26280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM2_26290	COG4848	Belongs to the UPF0354 family
TM2_26300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_26330	COG1363	Peptidase, m42
TM2_26340	COG5584	Small secreted protein
TM2_26350	COG0281	malic enzyme
TM2_26360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_26370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TM2_26390	COG0510	thiamine kinase activity
TM2_26400	COG1597	lipid kinase activity
TM2_26420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TM2_26430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TM2_26440	COG3340	Belongs to the peptidase S51 family
TM2_26450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TM2_26460	COG2252	PERMEase
TM2_26470	COG1349	DNA-binding transcription factor activity
TM2_26480	COG1187	pseudouridine synthase activity
TM2_26490	COG2244	polysaccharide biosynthetic process
TM2_26500	COG2081	HI0933 family
TM2_26520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TM2_26530	COG3196	Protein conserved in bacteria
TM2_26550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TM2_26560	COG5578	integral membrane protein
TM2_26570	COG0673	inositol 2-dehydrogenase activity
TM2_26580	COG1653	transport
TM2_26590	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
TM2_26600	COG4209	transmembrane transport
TM2_26610	COG2207	Transcriptional regulator
TM2_26620	COG1733	regulation of RNA biosynthetic process
TM2_26630	COG2814	Major facilitator Superfamily
TM2_26640	COG0656	L-ascorbic acid biosynthetic process
TM2_26650	COG1653	transport
TM2_26660	COG0395	ABC-type sugar transport system, permease component
TM2_26670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TM2_26680	COG1073	alpha beta
TM2_26690	COG0495	leucyl-tRNA aminoacylation
TM2_26710	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_26710	COG2202	Pas domain
TM2_26720	COG2433	Pfam Transposase IS66
TM2_26730	COG0577	efflux transmembrane transporter activity
TM2_26740	COG1136	(ABC) transporter
TM2_26760	COG1131	(ABC) transporter
TM2_26770	COG1725	Transcriptional regulator
TM2_26810	COG1242	4 iron, 4 sulfur cluster binding
TM2_26820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TM2_26830	COG4326	sporulation control protein
TM2_26850	COG2267	carboxylic ester hydrolase activity
TM2_26860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TM2_26870	COG0367	asparagine synthase
TM2_26880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TM2_26890	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TM2_26910	COG1506	peptidase
TM2_26920	COG1233	COG1233 Phytoene dehydrogenase and related
TM2_26960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TM2_26970	COG1116	anion transmembrane transporter activity
TM2_26980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TM2_26990	COG0494	nUDIX hydrolase
TM2_27000	COG2310	stress, protein
TM2_27030	COG4824	toxin secretion phage lysis holin
TM2_27050	COG0783	Belongs to the Dps family
TM2_27080	COG1854	S-ribosylhomocysteine lyase activity
TM2_27090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TM2_27100	COG0288	reversible hydration of carbon dioxide
TM2_27110	COG0803	Belongs to the bacterial solute-binding protein 9 family
TM2_27110	COG3443	Belongs to the bacterial solute-binding protein 9 family
TM2_27130	COG1271	oxidase subunit
TM2_27140	COG1294	oxidase, subunit
TM2_27170	COG4948	Mandelate Racemase Muconate Lactonizing
TM2_27180	COG0318	PFAM AMP-dependent synthetase and ligase
TM2_27190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TM2_27200	COG0596	Alpha beta hydrolase
TM2_27210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TM2_27220	COG1169	isochorismate synthase
TM2_27230	COG1575	Belongs to the MenA family. Type 1 subfamily
TM2_27240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TM2_27260	COG3859	Proton-coupled thiamine transporter YuaJ
TM2_27280	COG1247	-acetyltransferase
TM2_27290	COG3339	Conserved Protein
TM2_27300	COG0772	Belongs to the SEDS family
TM2_27310	COG0772	Belongs to the SEDS family
TM2_27320	COG2268	Band 7 protein
TM2_27330	COG1585	Membrane protein implicated in regulation of membrane protease activity
TM2_27340	COG2318	DinB family
TM2_27350	COG1454	alcohol dehydrogenase
TM2_27360	COG1012	belongs to the aldehyde dehydrogenase family
TM2_27370	COG1510	regulation of RNA biosynthetic process
TM2_27390	COG3409	Peptidoglycan-binding domain 1 protein
TM2_27390	COG5632	N-Acetylmuramoyl-L-alanine amidase
TM2_27500	COG3778	Protein conserved in bacteria
TM2_27510	COG3299	homolog of phage Mu protein gp47
TM2_27520	COG3628	GPW Gp25 family protein
TM2_27540	COG4193	domain, Protein
TM2_27550	COG1652	LysM domain
TM2_27560	COG5280	Phage tail tape measure protein TP901
TM2_27560	COG3953	SLT domain
TM2_27560	COG5280	Phage tail tape measure protein TP901
TM2_27560	COG3953	SLT domain
TM2_27660	COG4653	Phage capsid family
TM2_27670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
TM2_27680	COG5518	Phage portal protein
TM2_27690	COG1783	phage Terminase large subunit
TM2_27700	COG5484	DNA packaging
TM2_27710	COG1595	DNA-templated transcription, initiation
TM2_27730	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
TM2_27770	COG1396	sequence-specific DNA binding
TM2_27800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TM2_27830	COG0628	permease
TM2_27850	COG0673	inositol 2-dehydrogenase activity
TM2_27860	COG0693	protein deglycase activity
TM2_27870	COG0840	transmembrane signaling receptor activity
TM2_27880	COG0840	transmembrane signaling receptor activity
TM2_27890	COG0840	transmembrane signaling receptor activity
TM2_27900	COG0840	transmembrane signaling receptor activity
TM2_27930	COG2070	2-Nitropropane dioxygenase
TM2_27940	COG0432	Pfam Uncharacterised protein family UPF0047
TM2_27950	COG1253	flavin adenine dinucleotide binding
TM2_27960	COG2738	Putative neutral zinc metallopeptidase
TM2_27980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TM2_28010	COG0166	Belongs to the GPI family
TM2_28020	COG1979	alcohol dehydrogenase
TM2_28030	COG1979	alcohol dehydrogenase
TM2_28040	COG2155	Conserved Protein
TM2_28050	COG1098	S1 RNA binding domain
TM2_28060	COG0436	Aminotransferase
TM2_28070	COG1522	sequence-specific DNA binding
TM2_28080	COG2267	carboxylic ester hydrolase activity
TM2_28100	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TM2_28110	COG2205	protein histidine kinase activity
TM2_28140	COG5018	Exonuclease
TM2_28150	COG2814	Major facilitator Superfamily
TM2_28160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TM2_28170	COG3011	Protein conserved in bacteria
TM2_28190	COG3290	protein histidine kinase activity
TM2_28200	COG4565	transcriptional regulatory protein
TM2_28210	COG1744	ABC transporter substrate-binding protein PnrA-like
TM2_28220	COG3845	ABC transporter
TM2_28230	COG4603	Belongs to the binding-protein-dependent transport system permease family
TM2_28240	COG1079	Belongs to the binding-protein-dependent transport system permease family
TM2_28250	COG3493	citrate carrier protein
TM2_28270	COG2111	Na H antiporter
TM2_28270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TM2_28280	COG2111	Na H antiporter
TM2_28290	COG1006	Multisubunit Na H antiporter MnhC subunit
TM2_28300	COG0651	ATP synthesis coupled electron transport
TM2_28310	COG1863	multisubunit Na H antiporter MnhE subunit
TM2_28320	COG2212	antiporter activity
TM2_28330	COG1320	monovalent cation:proton antiporter activity
TM2_28340	COG2050	protein possibly involved in aromatic compounds catabolism
TM2_28350	COG2197	response regulator
TM2_28360	COG4585	Histidine kinase
TM2_28380	COG0142	geranyltranstransferase activity
TM2_28410	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TM2_28420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TM2_28430	COG1335	isochorismatase
TM2_28440	COG5506	Protein of unknown function (DUF1694)
TM2_28480	COG0628	permease
TM2_28510	COG1418	mRNA catabolic process
TM2_28520	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_28540	COG1511	domain protein
TM2_28550	COG0433	COG0433 Predicted ATPase
TM2_28550	COG1674	ftsk spoiiie
TM2_28560	COG4499	WXG100 protein secretion system (Wss), protein YukC
TM2_28570	COG5417	Belongs to the EsaB family
TM2_28580	COG4842	Belongs to the WXG100 family
TM2_28590	COG2508	Transcriptional regulator
TM2_28590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TM2_28600	COG0686	Belongs to the AlaDH PNT family
TM2_28610	COG1268	BioY protein
TM2_28620	COG2056	Na+-H+ antiporter family
TM2_28630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TM2_28650	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TM2_28660	COG3584	3D domain protein
TM2_28690	COG1252	NADH dehydrogenase
TM2_28700	COG0492	ferredoxin-NADP+ reductase activity
TM2_28730	COG0316	Belongs to the HesB IscA family
TM2_28740	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TM2_28750	COG4844	belongs to the
TM2_28760	COG1252	NADH dehydrogenase
TM2_28780	COG4837	Protein of unknown function (DUF1462)
TM2_28790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TM2_28800	COG0823	Involved in the tonB-independent uptake of proteins
TM2_28800	COG1506	peptidase
TM2_28800	COG4946	Tricorn protease homolog
TM2_28810	COG0083	homoserine kinase activity
TM2_28820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TM2_28830	COG0460	homoserine dehydrogenase
TM2_28840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TM2_28850	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TM2_28860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TM2_28870	COG0647	UMP catabolic process
TM2_28880	COG2445	Protein of unknown function DUF86
TM2_28890	COG4470	Protein conserved in bacteria
TM2_28910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TM2_28920	COG0739	heme binding
TM2_28960	COG3377	Domain of unknown function (DUF1805)
TM2_28970	COG0737	Belongs to the 5'-nucleotidase family
TM2_28980	COG1801	Protein of unknown function DUF72
TM2_28990	COG2508	Transcriptional regulator
TM2_29000	COG2140	Oxalate decarboxylase
TM2_29010	COG2814	Major facilitator Superfamily
TM2_29020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TM2_29030	COG2356	endonuclease I
TM2_29050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_29060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_29070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_29110	COG0642	Histidine kinase
TM2_29110	COG5002	protein histidine kinase activity
TM2_29120	COG0745	RESPONSE REGULATOR receiver
TM2_29130	COG2311	Membrane
TM2_29150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TM2_29160	COG1090	epimerase
TM2_29170	COG1309	transcriptional regulator
TM2_29210	COG0719	Fe-S assembly protein
TM2_29220	COG0822	iron-sulfur transferase activity
TM2_29230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TM2_29240	COG0719	Fe-S assembly protein
TM2_29250	COG0396	ATPase activity
TM2_29270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TM2_29280	COG1464	Belongs to the NlpA lipoprotein family
TM2_29290	COG2011	ABC-type metal ion transport system permease component
TM2_29300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TM2_29320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_29330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
TM2_29350	COG0509	glycine decarboxylation via glycine cleavage system
TM2_29360	COG1393	Belongs to the ArsC family
TM2_29370	COG1960	acyl-CoA dehydrogenase activity
TM2_29380	COG0183	Belongs to the thiolase family
TM2_29390	COG1024	Enoyl-CoA hydratase
TM2_29390	COG1250	3-hydroxyacyl-CoA dehydrogenase
TM2_29420	COG5577	PFAM Coat F domain
TM2_29440	COG1120	ATPase activity
TM2_29460	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_29470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TM2_29480	COG0745	RESPONSE REGULATOR receiver
TM2_29490	COG2205	protein histidine kinase activity
TM2_29490	COG2770	Histidine kinase
TM2_29510	COG1309	transcriptional regulator
TM2_29520	COG0114	fumarate hydratase activity
TM2_29540	COG0697	spore germination
TM2_29550	COG0814	amino acid
TM2_29580	COG2197	response regulator
TM2_29590	COG4585	Histidine kinase
TM2_29600	COG4758	membrane
TM2_29620	COG1842	Phage shock protein A
TM2_29630	COG4758	membrane
TM2_29640	COG2096	Adenosyltransferase
TM2_29650	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_29660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TM2_29680	COG3604	Transcriptional regulator
TM2_29710	COG1454	alcohol dehydrogenase
TM2_29720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TM2_29730	COG1120	ATPase activity
TM2_29740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_29750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_29770	COG2721	sulfolactate sulfo-lyase activity
TM2_29780	COG0246	Mannitol dehydrogenase
TM2_29790	COG1609	Transcriptional regulator
TM2_29800	COG1904	glucuronate isomerase
TM2_29810	COG2205	protein histidine kinase activity
TM2_29820	COG0745	RESPONSE REGULATOR receiver
TM2_29830	COG1120	ATPase activity
TM2_29840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_29850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_29860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_29870	COG0531	amino acid
TM2_29900	COG1988	membrane-bound metal-dependent
TM2_29910	COG1368	sulfuric ester hydrolase activity
TM2_29920	COG0725	ABC transporter, periplasmic molybdate-binding protein
TM2_29930	COG4149	molybdate abc transporter
TM2_29940	COG0656	L-ascorbic acid biosynthetic process
TM2_29950	COG1940	carbohydrate kinase activity
TM2_29960	COG0025	NhaP-type Na H and K H
TM2_29970	COG2860	membrane
TM2_29980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TM2_29990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TM2_30000	COG2217	Heavy metal translocating P-type atpase
TM2_30010	COG1121	(ABC) transporter
TM2_30020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TM2_30030	COG0803	Belongs to the bacterial solute-binding protein 9 family
TM2_30050	COG3226	Transcriptional regulator
TM2_30060	COG0784	Response regulator, receiver
TM2_30070	COG4191	Histidine kinase
TM2_30080	COG1027	Aspartate ammonia-lyase
TM2_30110	COG2217	Heavy metal translocating P-type atpase
TM2_30120	COG2608	mercury ion transmembrane transporter activity
TM2_30130	COG1937	Protein conserved in bacteria
TM2_30190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TM2_30200	COG0557	exoribonuclease II activity
TM2_30210	COG1647	Serine aminopeptidase, S33
TM2_30220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TM2_30230	COG2002	toxin-antitoxin pair type II binding
TM2_30240	COG1476	TRANSCRIPTIONal
TM2_30250	COG1396	sequence-specific DNA binding
TM2_30270	COG1396	sequence-specific DNA binding
TM2_30280	COG1733	regulation of RNA biosynthetic process
TM2_30290	COG1174	glycine betaine transport
TM2_30300	COG1732	Glycine betaine
TM2_30310	COG1174	glycine betaine transport
TM2_30320	COG0517	IMP dehydrogenase activity
TM2_30320	COG1125	glycine betaine transport
TM2_30330	COG1510	regulation of RNA biosynthetic process
TM2_30340	COG2095	MarC family integral membrane protein
TM2_30360	COG0456	acetyltransferase
TM2_30400	COG1131	(ABC) transporter
TM2_30420	COG0148	phosphopyruvate hydratase activity
TM2_30430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TM2_30440	COG0149	triose-phosphate isomerase activity
TM2_30450	COG0126	phosphoglycerate kinase activity
TM2_30460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TM2_30470	COG2390	Transcriptional regulator
TM2_30480	COG0833	amino acid
TM2_30490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TM2_30500	COG3829	transcription factor binding
TM2_30510	COG2186	Transcriptional regulator
TM2_30520	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TM2_30540	COG0534	Mate efflux family protein
TM2_30550	COG4608	Belongs to the ABC transporter superfamily
TM2_30560	COG0444	Belongs to the ABC transporter superfamily
TM2_30570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM2_30580	COG0601	transmembrane transport
TM2_30590	COG0747	negative chemotaxis
TM2_30600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TM2_30610	COG0110	maltose O-acetyltransferase activity
TM2_30620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TM2_30630	COG2244	polysaccharide biosynthetic process
TM2_30640	COG5039	Polysaccharide pyruvyl transferase
TM2_30650	COG1216	Glycosyl transferase, family 2
TM2_30670	COG0438	transferase activity, transferring glycosyl groups
TM2_30680	COG1215	transferase activity, transferring glycosyl groups
TM2_30690	COG0438	transferase activity, transferring glycosyl groups
TM2_30700	COG1086	Polysaccharide biosynthesis protein
TM2_30710	COG0489	protein tyrosine kinase activity
TM2_30720	COG3944	biosynthesis protein
TM2_30730	COG1396	sequence-specific DNA binding
TM2_30750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_30760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_30770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_30790	COG0726	polysaccharide deacetylase
TM2_30800	COG0488	(ABC) transporter
TM2_30810	COG4608	Belongs to the ABC transporter superfamily
TM2_30840	COG0601	transmembrane transport
TM2_30850	COG0747	negative chemotaxis
TM2_30860	COG1819	glycosyl
TM2_30890	COG0740	serine-type endopeptidase activity
TM2_30900	COG1611	Belongs to the LOG family
TM2_30910	COG1694	Mazg nucleotide pyrophosphohydrolase
TM2_30920	COG0659	secondary active sulfate transmembrane transporter activity
TM2_30930	COG0288	reversible hydration of carbon dioxide
TM2_30940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TM2_30960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
TM2_30970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_30980	COG1481	regulation of sporulation
TM2_30990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TM2_31000	COG1660	Displays ATPase and GTPase activities
TM2_31010	COG1051	belongs to the nudix hydrolase family
TM2_31020	COG0492	ferredoxin-NADP+ reductase activity
TM2_31030	COG0791	NLP P60 protein
TM2_31030	COG3883	PFAM NLP P60 protein
TM2_31050	COG0457	Tetratricopeptide repeat
TM2_31060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TM2_31060	COG0140	phosphoribosyl-ATP diphosphatase activity
TM2_31070	COG0107	imidazoleglycerol-phosphate synthase activity
TM2_31080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TM2_31090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TM2_31100	COG0131	Imidazoleglycerol-phosphate dehydratase
TM2_31110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TM2_31120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TM2_31130	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TM2_31140	COG4990	cell redox homeostasis
TM2_31150	COG2910	NAD(P)H-binding
TM2_31160	COG1959	2 iron, 2 sulfur cluster binding
TM2_31170	COG0110	maltose O-acetyltransferase activity
TM2_31180	COG0546	phosphoglycolate phosphatase activity
TM2_31190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TM2_31210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TM2_31220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TM2_31230	COG0363	glucosamine-6-phosphate deaminase activity
TM2_31240	COG2188	Transcriptional regulator
TM2_31250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TM2_31260	COG1950	PFAM Membrane protein of
TM2_31270	COG1983	PspC domain protein
TM2_31280	COG3595	metallopeptidase activity
TM2_31310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TM2_31330	COG4897	Protein conserved in bacteria
TM2_31340	COG0574	Belongs to the PEP-utilizing enzyme family
TM2_31340	COG3848	Pyruvate phosphate dikinase
TM2_31350	COG1309	transcriptional regulator
TM2_31360	COG2814	Major facilitator Superfamily
TM2_31380	COG0745	RESPONSE REGULATOR receiver
TM2_31390	COG5002	protein histidine kinase activity
TM2_31400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TM2_31410	COG0463	Glycosyl transferase, family 2
TM2_31420	COG1113	amino acid transport
TM2_31430	COG0778	Nitroreductase
TM2_31440	COG1733	regulation of RNA biosynthetic process
TM2_31450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TM2_31470	COG3409	Peptidoglycan-binding domain 1 protein
TM2_31470	COG0793	Belongs to the peptidase S41A family
TM2_31480	COG0730	response to heat
TM2_31490	COG0791	NLP P60 protein
TM2_31490	COG3883	PFAM NLP P60 protein
TM2_31500	COG2177	Part of the ABC transporter FtsEX involved in
TM2_31510	COG2884	Cell division ATP-binding protein ftsE
TM2_31520	COG2010	Cytochrome c
TM2_31530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM2_31560	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TM2_31570	COG0653	protein targeting
TM2_31580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TM2_31590	COG0840	transmembrane signaling receptor activity
TM2_31620	COG1516	flagellar protein fliS
TM2_31630	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TM2_31640	COG1334	flagellar protein FlaG
TM2_31650	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TM2_31660	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TM2_31680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM2_31690	COG1256	bacterial-type flagellum assembly
TM2_31690	COG4786	Flagellar basal body rod
TM2_31700	COG3418	PFAM FlgN family protein
TM2_31730	COG1040	competence protein
TM2_31750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
TM2_31760	COG1307	EDD domain protein, DegV family
TM2_31770	COG2197	response regulator
TM2_31780	COG4585	Histidine kinase
TM2_31790	COG1739	Uncharacterized protein family UPF0029
TM2_31800	COG1316	TRANSCRIPTIONal
TM2_31810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TM2_31820	COG0438	transferase activity, transferring glycosyl groups
TM2_31830	COG1215	transferase activity, transferring glycosyl groups
TM2_31840	COG3206	protein involved in exopolysaccharide biosynthesis
TM2_31850	COG3307	-O-antigen
TM2_31860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TM2_31870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TM2_31880	COG0438	transferase activity, transferring glycosyl groups
TM2_31880	COG0297	glycogen (starch) synthase activity
TM2_31890	COG2244	polysaccharide biosynthetic process
TM2_31920	COG0860	N-Acetylmuramoyl-L-alanine amidase
TM2_31920	COG2247	cell wall binding repeat
TM2_31930	COG0860	N-Acetylmuramoyl-L-alanine amidase
TM2_31930	COG2247	cell wall binding repeat
TM2_31940	COG2247	cell wall binding repeat
TM2_31940	COG2385	sporulation resulting in formation of a cellular spore
TM2_31960	COG1316	TRANSCRIPTIONal
TM2_31970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TM2_31980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TM2_31990	COG1134	teichoic acid transport
TM2_32000	COG1682	transport, permease protein
TM2_32020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TM2_32040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TM2_32050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TM2_32060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TM2_32070	COG4193	domain, Protein
TM2_32080	COG1482	cell wall glycoprotein biosynthetic process
TM2_32100	COG1175	transmembrane transport
TM2_32110	COG1653	transport
TM2_32120	COG2197	response regulator
TM2_32130	COG2972	Histidine kinase
TM2_32150	COG0454	-acetyltransferase
TM2_32160	COG0800	Aldolase
TM2_32170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TM2_32180	COG1609	Transcriptional regulator
TM2_32190	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TM2_32200	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_32210	COG0697	spore germination
TM2_32220	COG0814	amino acid
TM2_32250	COG2814	Major facilitator Superfamily
TM2_32260	COG1316	TRANSCRIPTIONal
TM2_32270	COG0561	phosphatase activity
TM2_32280	COG0791	NLP P60 protein
TM2_32300	COG2843	Capsule synthesis protein
TM2_32320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TM2_32330	COG0697	spore germination
TM2_32360	COG1609	Transcriptional regulator
TM2_32370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TM2_32380	COG1869	D-ribose catabolic process
TM2_32390	COG1129	ABC transporter
TM2_32400	COG1172	Belongs to the binding-protein-dependent transport system permease family
TM2_32410	COG1879	ABC-type sugar transport system periplasmic component
TM2_32420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TM2_32430	COG0583	DNA-binding transcription factor activity
TM2_32440	COG0028	Belongs to the TPP enzyme family
TM2_32450	COG3527	Alpha-acetolactate decarboxylase
TM2_32460	COG1522	sequence-specific DNA binding
TM2_32470	COG2059	Chromate
TM2_32480	COG2059	Chromate
TM2_32490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TM2_32510	COG4715	Zinc finger, swim domain protein
TM2_32520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TM2_32530	COG2202	Pas domain
TM2_32530	COG1366	Belongs to the anti-sigma-factor antagonist family
TM2_32540	COG0561	phosphatase activity
TM2_32570	COG1970	mechanosensitive ion channel activity
TM2_32580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TM2_32590	COG0457	Tetratricopeptide repeat
TM2_32600	COG4786	Flagellar basal body rod
TM2_32610	COG4786	Flagellar basal body rod
TM2_32620	COG1077	Cell shape determining protein MreB Mrl
TM2_32630	COG1609	Transcriptional regulator
TM2_32650	COG1846	Transcriptional regulator
TM2_32660	COG2814	Major facilitator Superfamily
TM2_32670	COG0671	phosphoesterase, PA-phosphatase related
TM2_32680	COG0477	Major facilitator Superfamily
TM2_32690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_32700	COG0765	amino acid transport
TM2_32710	COG1126	abc transporter atp-binding protein
TM2_32720	COG0004	ammonium transporteR
TM2_32730	COG0347	Belongs to the P(II) protein family
TM2_32740	COG0739	heme binding
TM2_32750	COG1247	-acetyltransferase
TM2_32830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TM2_32840	COG0523	cobalamin synthesis protein
TM2_32850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TM2_32860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TM2_32870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TM2_32880	COG2223	nitrite transmembrane transporter activity
TM2_32900	COG2304	oxidoreductase activity
TM2_32910	COG2304	oxidoreductase activity
TM2_32920	COG2385	sporulation resulting in formation of a cellular spore
TM2_32930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TM2_32950	COG4836	Membrane
TM2_32970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TM2_32980	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TM2_32990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TM2_33000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TM2_33010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TM2_33020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TM2_33030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TM2_33040	COG0356	it plays a direct role in the translocation of protons across the membrane
TM2_33060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TM2_33070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TM2_33080	COG4475	Protein of unknown function (DUF436)
TM2_33090	COG0698	ribose 5-phosphate isomerase
TM2_33100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TM2_33110	COG1971	Probably functions as a manganese efflux pump
TM2_33120	COG0009	L-threonylcarbamoyladenylate synthase
TM2_33130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TM2_33160	COG2890	protein-(glutamine-N5) methyltransferase activity
TM2_33170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TM2_33180	COG0789	Transcriptional regulator
TM2_33190	COG0679	Auxin Efflux Carrier
TM2_33200	COG0281	malic enzyme
TM2_33210	COG1435	thymidine kinase activity
TM2_33220	COG0254	rRNA binding
TM2_33230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TM2_33240	COG1494	fructose-1,6-bisphosphatase
TM2_33250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TM2_33260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TM2_33270	COG0191	fructose-bisphosphate aldolase activity
TM2_33280	COG2204	response regulator
TM2_33290	COG4821	SIS domain
TM2_33300	COG0504	CTP synthase activity
TM2_33310	COG3343	RNA polymerase activity
TM2_33340	COG1960	acyl-CoA dehydrogenase activity
TM2_33350	COG1960	acyl-CoA dehydrogenase activity
TM2_33360	COG1250	3-hydroxyacyl-CoA dehydrogenase
TM2_33370	COG0183	Belongs to the thiolase family
TM2_33380	COG0247	lactate metabolic process
TM2_33380	COG2181	nitrate reductase activity
TM2_33390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TM2_33400	COG4294	response to UV
TM2_33420	COG1619	proteins homologs of microcin C7 resistance protein MccF
TM2_33440	COG1132	(ABC) transporter
TM2_33450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TM2_33460	COG1619	proteins homologs of microcin C7 resistance protein MccF
TM2_33470	COG0018	arginyl-trna synthetase
TM2_33480	COG4506	Protein conserved in bacteria
TM2_33500	COG0010	Belongs to the arginase family
TM2_33510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TM2_33520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TM2_33540	COG1994	Peptidase M50
TM2_33550	COG1942	4-Oxalocrotonate Tautomerase
TM2_33570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_33580	COG0583	DNA-binding transcription factor activity
TM2_33590	COG0431	NADPH-dependent FMN reductase
TM2_33600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_33610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TM2_33620	COG0454	-acetyltransferase
TM2_33630	COG0765	amino acid transport
TM2_33650	COG0765	amino acid transport
TM2_33660	COG1126	abc transporter atp-binding protein
TM2_33670	COG3465	dGTPase activity
TM2_33680	COG1078	dGTPase activity
TM2_33690	COG4844	belongs to the
TM2_33770	COG5444	nuclease activity
TM2_33830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TM2_33850	COG0280	phosphate acetyltransferase
TM2_33870	COG2814	Major facilitator Superfamily
TM2_33880	COG1522	sequence-specific DNA binding
TM2_33890	COG2814	Major facilitator Superfamily
TM2_33900	COG0077	Prephenate dehydratase
TM2_33910	COG1917	Cupin 2, conserved barrel domain protein
TM2_33920	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_33930	COG0151	Belongs to the GarS family
TM2_33940	COG0436	Aminotransferase
TM2_33950	COG1028	Short-chain dehydrogenase reductase Sdr
TM2_33960	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TM2_33970	COG1091	dTDP-4-dehydrorhamnose reductase activity
TM2_33980	COG1088	dTDP-glucose 4,6-dehydratase activity
TM2_33990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TM2_34000	COG3980	spore coat polysaccharide biosynthesis protein
TM2_34010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TM2_34020	COG2089	acid synthase
TM2_34030	COG0456	acetyltransferase
TM2_34040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TM2_34050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TM2_34060	COG0463	Glycosyl transferase, family 2
TM2_34100	COG2363	Small membrane protein
TM2_34110	COG2233	PERMEase
TM2_34130	COG1012	belongs to the aldehyde dehydrogenase family
TM2_34140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TM2_34150	COG1216	Glycosyl transferase, family 2
TM2_34170	COG0351	phosphomethylpyrimidine kinase
TM2_34200	COG1621	beta-fructofuranosidase activity
TM2_34210	COG1263	PTS System
TM2_34210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_34220	COG3711	transcriptional antiterminator
TM2_34240	COG1404	Belongs to the peptidase S8 family
TM2_34250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TM2_34260	COG0778	Nitroreductase
TM2_34270	COG0772	Belongs to the SEDS family
TM2_34290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TM2_34300	COG1845	cytochrome c oxidase, subunit III
TM2_34310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TM2_34320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TM2_34340	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
TM2_34350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TM2_34360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TM2_34390	COG2246	polysaccharide biosynthetic process
TM2_34430	COG3162	membrane
TM2_34440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TM2_34490	COG0352	thiamine-phosphate diphosphorylase activity
TM2_34500	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TM2_34510	COG0583	DNA-binding transcription factor activity
TM2_34520	COG1380	Effector of murein hydrolase LrgA
TM2_34530	COG1346	cytolysis
TM2_34540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TM2_34550	COG0346	lactoylglutathione lyase activity
TM2_34570	COG0765	amino acid transport
TM2_34580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TM2_34590	COG0457	Tetratricopeptide repeat
TM2_34610	COG2357	RelA SpoT domain protein
TM2_34620	COG1172	Belongs to the binding-protein-dependent transport system permease family
TM2_34630	COG1129	ABC transporter
TM2_34650	COG3420	alginic acid biosynthetic process
TM2_34660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TM2_34690	COG1486	melibiose metabolic process
TM2_34700	COG1447	Phosphotransferase system cellobiose-specific component IIA
TM2_34710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_34720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_34730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_34730	COG3711	transcriptional antiterminator
TM2_34760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TM2_34790	COG1595	DNA-templated transcription, initiation
TM2_34810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TM2_34820	COG4988	ABC transporter
TM2_34830	COG1294	oxidase, subunit
TM2_34840	COG1271	oxidase subunit
TM2_34850	COG1120	ATPase activity
TM2_34860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM2_34870	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TM2_34880	COG4509	Sortase family
TM2_34930	COG5386	Cell surface protein
TM2_34940	COG5386	Cell surface protein
TM2_34950	COG1733	regulation of RNA biosynthetic process
TM2_34960	COG2514	catechol 2,3-dioxygenase activity
TM2_34970	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_34970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM2_34980	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM2_34980	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM2_35000	COG0726	polysaccharide deacetylase
TM2_35010	COG1447	Phosphotransferase system cellobiose-specific component IIA
TM2_35020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_35030	COG2723	6-phospho-beta-galactosidase activity
TM2_35040	COG1312	Catalyzes the dehydration of D-mannonate
TM2_35050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TM2_35060	COG3711	transcriptional antiterminator
TM2_35060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TM2_35110	COG1757	Na H antiporter
TM2_35120	COG1027	Aspartate ammonia-lyase
TM2_35130	COG0252	asparaginase activity
TM2_35140	COG1396	sequence-specific DNA binding
TM2_35190	COG4842	Belongs to the WXG100 family
TM2_35200	COG2195	Cleaves the N-terminal amino acid of tripeptides
TM2_35230	COG1737	Transcriptional regulator
TM2_35240	COG2084	Dehydrogenase
TM2_35260	COG2610	gluconate transmembrane transporter activity
TM2_35270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TM2_35290	COG1136	(ABC) transporter
TM2_35300	COG2723	6-phospho-beta-galactosidase activity
TM2_35310	COG2190	(PTS) system
TM2_35310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_35310	COG1263	PTS System
TM2_35320	COG3711	transcriptional antiterminator
TM2_35340	COG3878	Protein conserved in bacteria
TM2_35360	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TM2_35370	COG1122	ATPase activity
TM2_35380	COG4721	ABC-type cobalt transport system, permease component
TM2_35390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TM2_35460	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
TM2_35470	COG0778	Nitroreductase
TM2_35480	COG1846	Transcriptional regulator
TM2_35490	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TM2_35500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TM2_35510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TM2_35520	COG2390	Transcriptional regulator
TM2_35540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TM2_35540	COG2755	lipolytic protein G-D-S-L family
TM2_35550	COG0477	Major facilitator Superfamily
TM2_35560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TM2_35570	COG2226	methyltransferase
TM2_35590	COG0561	phosphatase activity
TM2_35600	COG0789	Transcriptional regulator
TM2_35610	COG0673	inositol 2-dehydrogenase activity
TM2_35620	COG0840	transmembrane signaling receptor activity
TM2_35630	COG1113	amino acid transport
TM2_35640	COG4335	DNA alkylation repair
TM2_35660	COG1070	Carbohydrate kinase
TM2_35670	COG1737	Transcriptional regulator
TM2_35750	COG0583	DNA-binding transcription factor activity
TM2_35760	COG1609	Transcriptional regulator
TM2_35770	COG2182	Extracellular solute-binding protein
TM2_35780	COG1175	transmembrane transport
TM2_35790	COG3833	ABC-type maltose transport systems, permease component
TM2_35810	COG1874	Beta-galactosidase
TM2_35820	COG2851	Citrate transporter
TM2_35840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TM2_35850	COG1131	(ABC) transporter
TM2_35860	COG2824	Alkylphosphonate utilization operon protein PhnA
TM2_35870	COG1929	Belongs to the glycerate kinase type-1 family
TM2_35880	COG2610	gluconate transmembrane transporter activity
TM2_35890	COG3835	regulator
TM2_35900	COG1309	transcriptional regulator
TM2_35910	COG2814	Major facilitator Superfamily
TM2_35930	COG1136	(ABC) transporter
TM2_35950	COG0457	Tetratricopeptide repeat
TM2_35960	COG3711	transcriptional antiterminator
TM2_35970	COG2723	6-phospho-beta-galactosidase activity
TM2_35980	COG1263	PTS System
TM2_35980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TM2_35980	COG2190	(PTS) system
TM2_36030	COG0494	nUDIX hydrolase
TM2_36060	COG1113	amino acid transport
TM2_36070	COG1609	Transcriptional regulator
TM2_36080	COG2814	Major facilitator Superfamily
TM2_36090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TM2_36100	COG2814	Major facilitator Superfamily
TM2_36160	COG5444	nuclease activity
TM2_36190	COG2723	6-phospho-beta-galactosidase activity
TM2_36210	COG2188	Transcriptional regulator
TM2_36240	COG0384	phenazine biosynthesis protein PhzF
TM2_36250	COG0583	DNA-binding transcription factor activity
TM2_36290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TM2_36320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM2_36340	COG0210	DNA helicase
TM2_36380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TM2_36400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TM2_36420	COG4720	Psort location CytoplasmicMembrane, score
TM2_36460	COG0456	acetyltransferase
TM2_36470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TM2_36480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TM2_36490	COG4853	Protein conserved in bacteria
TM2_36500	COG4863	YycH protein
TM2_36510	COG5002	protein histidine kinase activity
TM2_36520	COG0745	RESPONSE REGULATOR receiver
TM2_36530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TM2_36550	COG2311	Membrane
TM2_36560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TM2_36570	COG1309	transcriptional regulator
TM2_36580	COG2124	cytochrome p450
TM2_36590	COG0346	lactoylglutathione lyase activity
TM2_36600	COG0305	Participates in initiation and elongation during chromosome replication
TM2_36630	COG2819	hydrolase of the alpha beta superfamily
TM2_36640	COG2207	Transcriptional regulator
TM2_36640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_36650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM2_36660	COG2819	hydrolase of the alpha beta superfamily
TM2_36670	COG3093	addiction module antidote protein HigA
TM2_36680	COG2807	transmembrane transport
TM2_36690	COG0359	binds to the 23S rRNA
TM2_36700	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TM2_36710	COG4241	membrane
TM2_36720	COG1227	inorganic diphosphatase activity
TM2_36740	COG1595	DNA-templated transcription, initiation
TM2_36760	COG0753	catalase activity
TM2_36770	COG0655	NAD(P)H dehydrogenase (quinone) activity
TM2_36780	COG0400	carboxylic ester hydrolase activity
TM2_36790	COG0346	lactoylglutathione lyase activity
TM2_36800	COG1174	glycine betaine transport
TM2_36810	COG1125	glycine betaine transport
TM2_36810	COG0517	IMP dehydrogenase activity
TM2_36820	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TM2_36830	COG0629	single-stranded DNA binding
TM2_36840	COG0360	Binds together with S18 to 16S ribosomal RNA
TM2_36850	COG0012	GTP binding
TM2_36860	COG4481	Protein conserved in bacteria
TM2_36890	COG3949	Membrane
TM2_36910	COG1475	DNA binding
TM2_36920	COG1192	Involved in chromosome partitioning
TM2_36940	COG1475	DNA binding
TM2_36950	COG0357	Ribosomal RNA small subunit methyltransferase G
TM2_36960	COG0445	tRNA wobble uridine modification
TM2_36970	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TM2_36980	COG1847	R3H domain protein
TM2_36990	COG0706	membrane insertase activity
TM2_37000	COG0594	ribonuclease P activity
TM2_37010	COG0230	Belongs to the bacterial ribosomal protein bL34 family