locus-tag class description HTY60_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HTY60_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HTY60_00015 ENOG410848D S4 domain protein YaaA HTY60_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HTY60_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HTY60_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HTY60_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HTY60_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HTY60_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HTY60_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HTY60_00095 ENOG4105BZW Glycerate kinase HTY60_00105 ENOG4105ZMH deoxynucleoside kinase HTY60_00115 ENOG4105VRS hydrolase family 18 HTY60_00120 ENOG4105GTG Isochorismatase HTY60_00125 ENOG4108Z6B deaminase HTY60_00135 ENOG4105C6E dna polymerase iii HTY60_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HTY60_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HTY60_00155 ENOG41067KS pro-sigma K processing HTY60_00195 ENOG4105CDW Resistance protein HTY60_00200 ENOG4105CXN decarboxylase HTY60_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HTY60_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II HTY60_00215 ENOG4105XVJ Protein of unknown function (DUF327) HTY60_00220 ENOG4105FA2 dna polymerase iii HTY60_00225 ENOG4105MA4 psp1 domain protein HTY60_00235 ENOG41060K3 Methyltransferase HTY60_00240 ENOG4105VC4 domain protein HTY60_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HTY60_00250 ENOG4105KRN Transcriptional regulator, abrb family HTY60_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HTY60_00260 ENOG4105F8V Hydrolase, tatD family HTY60_00265 ENOG41069ER domain protein HTY60_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HTY60_00280 ENOG4105XFA sporulation peptidase YabG HTY60_00285 ENOG4105W42 Veg protein HTY60_00290 ENOG4105XEW small acid-soluble spore protein HTY60_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HTY60_00300 ENOG4105DFT pur operon repressor HTY60_00305 ENOG4105KME endoribonuclease L-psp HTY60_00310 ENOG4105K4W Could be involved in septation (By similarity) HTY60_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HTY60_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HTY60_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HTY60_00340 ENOG4108JA2 transcriptioN-repair coupling factor HTY60_00345 ENOG4108M14 stage v sporulation protein t HTY60_00355 ENOG4108IY2 MazG family HTY60_00360 ENOG41082I2 s4 domain protein HTY60_00365 ENOG4105VYY sporulation protein yabp HTY60_00380 ENOG41060GV RNA binding s1 domain protein HTY60_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HTY60_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase HTY60_00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HTY60_00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HTY60_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HTY60_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HTY60_00440 ENOG4105C6T cysteine synthase HTY60_00445 ENOG4105CRQ synthase (Component I) HTY60_00450 ENOG4105DDQ anthranilate synthase HTY60_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HTY60_00460 ENOG4105EEI dihydropteroate synthase HTY60_00465 ENOG4105KRF dihydroneopterin aldolase HTY60_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HTY60_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HTY60_00485 ENOG4105CRK lysyL-tRNA synthetase HTY60_00570 ENOG4108Z0C Uvrb UvrC protein HTY60_00575 ENOG41066A3 ATP guanido phosphotransferase HTY60_00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HTY60_00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HTY60_00595 ENOG4105CTP PilT protein domain protein HTY60_00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HTY60_00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HTY60_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HTY60_00615 ENOG4105D7W serine acetyltransferase HTY60_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HTY60_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 HTY60_00635 ENOG4105M0M Tetracycline resistance protein HTY60_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HTY60_00670 ENOG4108VZM 50s ribosomal protein L10 HTY60_00680 ENOG4107Y49 methyltransferase HTY60_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HTY60_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HTY60_00695 ENOG4105XPM ribosomal protein HTY60_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HTY60_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HTY60_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HTY60_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HTY60_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HTY60_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HTY60_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HTY60_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HTY60_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HTY60_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HTY60_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HTY60_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HTY60_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HTY60_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HTY60_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HTY60_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HTY60_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HTY60_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HTY60_00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HTY60_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HTY60_00850 ENOG41067V7 50S ribosomal protein L36 HTY60_00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HTY60_00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HTY60_00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HTY60_00870 ENOG4108ZT0 50S ribosomal protein l17 HTY60_00875 ENOG4108JJB ABC transporter HTY60_00880 ENOG4108JJB ABC transporter HTY60_00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HTY60_00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HTY60_00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HTY60_00900 ENOG4108UJD 30S ribosomal protein S9 HTY60_00905 ENOG4108I0C methyltransferase HTY60_00920 ENOG4105D1F ATP-binding protein HTY60_00935 ENOG4108NMV polysaccharide deacetylase HTY60_01000 ENOG4108JPW Aminotransferase HTY60_01010 ENOG4105CPQ Dehydrogenase HTY60_01015 ENOG4105CHH sulfate transporter HTY60_01025 ENOG4108SA1 esterase HTY60_01045 ENOG410874W AraC family transcriptional regulator HTY60_01050 ENOG4105EHZ conserved protein UCP016719 HTY60_01055 ENOG4105D17 glycoside hydrolase, family 3 domain protein HTY60_01070 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HTY60_01080 ENOG4105EWC Purine nucleoside phosphorylase HTY60_01110 ENOG4105EMN RNA polymerase sigma factor HTY60_01120 ENOG4105C8B TIGR00159 family HTY60_01125 ENOG4107U5W ybbr family HTY60_01130 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HTY60_01160 ENOG4106K80 HTY60_01170 ENOG41067MG lrgb family HTY60_01180 ENOG41061AU MarR family Transcriptional regulator HTY60_01195 ENOG4105BZU Histidine kinase HTY60_01200 ENOG4105WH1 Two component transcriptional regulator luxr family HTY60_01205 ENOG4105CJ1 ABC, transporter HTY60_01215 ENOG41090VJ ABC-2 type transporter HTY60_01230 ENOG4106DDH Sporulation-specific SASP protein HTY60_01245 ENOG4107QTZ amino acid HTY60_01255 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HTY60_01260 ENOG4105CXY transporter HTY60_01280 ENOG4107SCQ Iron-containing alcohol dehydrogenase HTY60_01285 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HTY60_01290 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HTY60_01295 ENOG4107ZTW SNARE associated Golgi HTY60_01310 ENOG4105C72 UPF0176 protein HTY60_01320 ENOG4105CM2 brancheD-chain amino acid aminotransferase HTY60_01325 ENOG4108IQI permease HTY60_01330 ENOG4108J5H Homocysteine s-methyltransferase HTY60_01365 ENOG41076HS cation diffusion facilitator family transporter HTY60_01375 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HTY60_01380 ENOG4108VGI doxx family HTY60_01385 ENOG4105XXY Thioredoxin HTY60_01405 ENOG4105DGI Alkaline phosphatase HTY60_01410 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HTY60_01415 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HTY60_01420 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HTY60_01425 ENOG4107EPV Aminotransferase class V HTY60_01430 ENOG4105C0R drug resistance transporter emrb qaca subfamily HTY60_01435 ENOG4105J7D transcriptional regulator HTY60_01445 ENOG41060AI SEC-C motif HTY60_01450 ENOG4107SET aldo keto reductase HTY60_01480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HTY60_01495 ENOG4105U3E Transcriptional regulator HTY60_01500 ENOG4105DSE periplasmic solute binding protein HTY60_01505 ENOG4105DIK (ABC) transporter HTY60_01515 ENOG4105DEN Luciferase family HTY60_01520 ENOG4108N0M stress protein HTY60_01525 ENOG4106FN3 tellurium resistance protein HTY60_01530 ENOG4106FN3 tellurium resistance protein HTY60_01535 ENOG4107TS3 membrane protein, TerC HTY60_01540 ENOG4108TTB tellurium resistance protein HTY60_01550 ENOG41079KZ Major Facilitator Superfamily HTY60_01555 ENOG4108IJ7 Glycine betaine HTY60_01560 ENOG4107SQ8 Glycine betaine HTY60_01590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HTY60_01625 ENOG4105EIG urea carboxylase-associated protein 1 HTY60_01630 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HTY60_01635 ENOG4108WBH protein TIM barrel HTY60_01645 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HTY60_01650 ENOG4105I82 acetyl xylan esterase HTY60_01655 ENOG410756H nucleotidyltransferase HTY60_01665 ENOG4105C26 Dehydrogenase HTY60_01675 ENOG4107YHD transcriptional regulator HTY60_01680 ENOG4105CAY ferredoxin--nadp reductase HTY60_01685 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HTY60_01690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HTY60_01695 ENOG4108IFG nitrite reductase, (NAD(P)H) HTY60_01705 ENOG4105CKI cobalamin synthesis protein HTY60_01710 ENOG4105E2A Dehydrogenase HTY60_01715 ENOG4105HHM rdd domain containing protein HTY60_01725 ENOG4105CS2 ec 3.2.1.21 HTY60_01740 ENOG41080HJ 6-phospho 3-hexuloisomerase HTY60_01745 ENOG4108VA3 3-hexulose-6-phosphate synthase HTY60_01750 ENOG4105KVH Transcriptional regulator HTY60_01755 ENOG4105CEY Amp-dependent synthetase and ligase HTY60_01775 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HTY60_01790 ENOG4105CDA abc transporter atp-binding protein HTY60_01795 ENOG4105DRP amino acid AbC transporter HTY60_01805 ENOG4106P55 Transcriptional regulator HTY60_01810 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HTY60_01815 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HTY60_01820 ENOG41069ZX HTY60_01830 ENOG4105DUX Transporter HTY60_01845 ENOG4105E1K spore germination protein HTY60_01870 ENOG4105EAB amino acid AbC transporter HTY60_01875 ENOG4108HW4 amino acid AbC transporter HTY60_01890 ENOG4108PGP mmge prpd family protein HTY60_01900 ENOG4107WD8 ABC transporter, permease HTY60_01905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HTY60_01910 ENOG4105BZU Histidine kinase HTY60_01930 ENOG4105CFH Aspartokinase HTY60_01935 ENOG4105DHS permease protein HTY60_01940 ENOG4105CM4 permease protein HTY60_01945 ENOG4108IPW abc transporter atp-binding protein HTY60_01960 ENOG4105R8C Transcriptional regulator HTY60_01965 ENOG4108DBC nitroreductase HTY60_01970 ENOG41067V3 Antibiotic biosynthesis monooxygenase HTY60_01975 ENOG4105YVS arsR family transcriptional regulator HTY60_01985 ENOG4108JPW Aminotransferase HTY60_01990 ENOG4105C26 Dehydrogenase HTY60_02000 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HTY60_02005 ENOG4105KTB nuclear export factor GLE1 HTY60_02010 ENOG4108T5E Copper resistance protein HTY60_02015 ENOG4108ZYE Transcriptional regulator HTY60_02035 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HTY60_02055 ENOG4105E7W lamb ycsf family protein HTY60_02060 ENOG4105C5A transporter HTY60_02065 ENOG4105CFM UPF0317 protein HTY60_02070 ENOG4105P4J Allophanate hydrolase, subunit 1 HTY60_02080 ENOG4107258 Transcriptional regulator HTY60_02085 ENOG4105XJB lipolytic protein G-D-S-L family HTY60_02095 ENOG41061CK Antibiotic biosynthesis monooxygenase HTY60_02100 ENOG4107RVG penicillin-binding protein HTY60_02105 ENOG4107QM2 Aldo Keto reductase HTY60_02110 ENOG4105ETD TRANSCRIPTIONal HTY60_02120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HTY60_02135 ENOG410606W general stress protein HTY60_02145 ENOG4105VCH membrane HTY60_02155 ENOG4105C9U ATP-dependent DNA helicase RecQ HTY60_02170 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HTY60_02175 ENOG4107R8N Glycosyl transferase, family 2 HTY60_02185 ENOG4105C0X amino acid HTY60_02200 ENOG41068KG domain protein HTY60_02205 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HTY60_02240 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HTY60_02250 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HTY60_02255 ENOG4105RXJ HTY60_02260 ENOG4105KPY Small multidrug resistance protein HTY60_02265 ENOG4105EU9 HTY60_02270 ENOG4105QVS general stress protein HTY60_02275 ENOG41082W1 Cupin 2, conserved barrel domain protein HTY60_02295 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HTY60_02300 ENOG4108MRH transcriptional regulatory protein HTY60_02305 ENOG4107QJT sodium dicarboxylate symporter HTY60_02310 ENOG4106F5Q Membrane HTY60_02315 ENOG4105CJ1 ABC, transporter HTY60_02330 ENOG4105FDT acyl-CoA dehydrogenase HTY60_02350 ENOG4105SZ6 Thioredoxin HTY60_02355 ENOG4105CPF Cell wall formation (By similarity) HTY60_02360 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HTY60_02365 ENOG4105C1J atp-dependent rna helicase HTY60_02370 ENOG410905X membrane-flanked domain protein HTY60_02375 ENOG4105CKV Membrane HTY60_02385 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HTY60_02390 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HTY60_02395 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HTY60_02405 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HTY60_02410 ENOG4107MMM Anti-sigma-factor antagonist HTY60_02415 ENOG4105FUA antagonist HTY60_02420 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HTY60_02425 ENOG4107SGM protein serine threonine phosphatase HTY60_02430 ENOG4105WN5 stage II sporulation protein HTY60_02435 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HTY60_02445 ENOG41064BQ Phosphatase HTY60_02460 ENOG410906U SprT-like HTY60_02505 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HTY60_02525 ENOG4106DF4 Sigma-70, region 4 HTY60_02545 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HTY60_02550 ENOG41068WC Domain of unknown function (DUF955) HTY60_02555 ENOG4108IMY Transcriptional regulator HTY60_02570 ENOG4108RYM conjugative transposon protein HTY60_02575 ENOG4106BHR ftsk SpoIIIE family protein HTY60_02580 ENOG4106128 DNA-binding helix-turn-helix protein HTY60_02640 ENOG4105P1M Domain of unknown function (DUF1874) HTY60_02650 ENOG4105K4H Nlp p60 protein HTY60_02690 ENOG4106ANW SMI1_KNR4 HTY60_02695 ENOG4106BHF HTY60_02710 ENOG410847I Transcriptional regulator, BadM Rrf2 family HTY60_02720 ENOG4105VEQ Cold shock protein HTY60_02740 ENOG4107U9B transcriptional regulator HTY60_02745 ENOG4105DXI Major Facilitator superfamily HTY60_02760 ENOG4105DNP FAD linked oxidase domain protein HTY60_02770 ENOG4105PGM cation diffusion facilitator family transporter HTY60_02780 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HTY60_02785 ENOG4108U7W acetyltransferase HTY60_02790 ENOG41086D8 Transcriptional regulator HTY60_02810 ENOG4105DQ4 alcohol dehydrogenase HTY60_02815 ENOG4105VUF Transcriptional regulator HTY60_02825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HTY60_02835 ENOG4105EQ0 Major Facilitator superfamily HTY60_02840 ENOG4108JGH Tetr family transcriptional regulator HTY60_02845 ENOG4105T38 integral membrane protein HTY60_02850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HTY60_02865 ENOG4105E2A Dehydrogenase HTY60_02870 ENOG4105PGS Spore coat protein HTY60_02880 ENOG4105EYF MMPL domain protein HTY60_02900 ENOG4108JYZ YitT family HTY60_02910 ENOG4105C2C drug resistance transporter, Bcr CflA HTY60_02915 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HTY60_02935 ENOG41090E6 transcriptional regulator MERR family HTY60_02950 ENOG4105EBM Alpha Beta Hydrolase Fold protein HTY60_02955 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HTY60_02960 ENOG4105DRR Transcriptional regulator, GntR family HTY60_02975 ENOG4105FQP Beta-lactamase HTY60_02985 ENOG41090UD (LipO)protein HTY60_02990 ENOG4108SUT Major Facilitator Superfamily HTY60_02995 ENOG4108TZY GntR Family Transcriptional Regulator HTY60_03000 ENOG4105JXH GntR family transcriptional regulator HTY60_03005 ENOG4105DJ2 Major Facilitator Superfamily HTY60_03025 ENOG4107QTZ amino acid HTY60_03045 ENOG4107QNK )-transporter HTY60_03090 ENOG4105K8N protein family UPF0079, ATPase HTY60_03095 ENOG41072GX Peptidase M22 Glycoprotease HTY60_03100 ENOG410801F ribosomal-protein-alanine acetyltransferase HTY60_03105 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HTY60_03110 ENOG4105C5H ABC transporter HTY60_03115 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HTY60_03120 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HTY60_03125 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HTY60_03130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HTY60_03140 ENOG4108TYN CAAX amino terminal protease family protein HTY60_03150 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HTY60_03220 ENOG4108PNI recT protein HTY60_03365 ENOG4105IG6 Phage terminase, large subunit HTY60_03490 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HTY60_03500 ENOG4105ESF Peptidoglycan binding domain protein HTY60_03515 ENOG4105PGZ NB-ARC domain HTY60_03520 ENOG4105CPQ Dehydrogenase HTY60_03525 ENOG4105CT4 transporter HTY60_03540 ENOG41087YS Phage shock protein A HTY60_03545 ENOG4105DQX Zinc finger domain HTY60_03550 ENOG4108WV1 Pfam:DUF477 HTY60_03560 ENOG4105EXC Acyl-transferase HTY60_03565 ENOG4108P49 AntiSigma factor HTY60_03570 ENOG4105JVQ RNA Polymerase HTY60_03600 ENOG4107STQ Multicopper oxidase HTY60_03605 ENOG4105C85 amino acid HTY60_03615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HTY60_03630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HTY60_03645 ENOG4105C7N Xanthine uracil vitamin C permease HTY60_03670 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HTY60_03675 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HTY60_03680 ENOG4105C83 adenylosuccinate lyase HTY60_03685 ENOG4105C8V SAICAR synthetase HTY60_03690 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HTY60_03695 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HTY60_03700 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HTY60_03710 ENOG4105CXB phosphoribosylaminoimidazole synthetase HTY60_03715 ENOG4108V3E phosphoribosylglycinamide formyltransferase HTY60_03720 ENOG4105DC1 bifunctional purine biosynthesis protein purh HTY60_03725 ENOG4105C12 Phosphoribosylglycinamide synthetase HTY60_03735 ENOG4105DVH amino acid HTY60_03750 ENOG4108R5T secreted protein HTY60_03755 ENOG4105KGF protein, YerC YecD HTY60_03760 ENOG4105CBC glutamate synthase HTY60_03770 ENOG4105C4R Atp-dependent dna helicase HTY60_03775 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HTY60_03785 ENOG4105CRN Aminoglycoside phosphotransferase HTY60_03790 ENOG4105KT7 mgtC SapB transporter HTY60_03795 ENOG4105CK7 Sodium proline symporter HTY60_03800 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HTY60_03805 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HTY60_03810 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HTY60_03815 ENOG4108IG5 Transcriptional regulator HTY60_03825 ENOG4105CBD Diacylglycerol kinase HTY60_03830 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HTY60_03845 ENOG4105CJ1 ABC, transporter HTY60_03880 ENOG4106BHF HTY60_03885 ENOG4105CDY transcriptional regulatory protein HTY60_03895 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HTY60_03910 ENOG4105WEF catalase HTY60_03915 ENOG4105M18 -acetyltransferase HTY60_03925 ENOG4105H67 Protein of unknown function (DUF421) HTY60_03930 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HTY60_03935 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HTY60_03955 ENOG4106I4J membrane HTY60_03960 ENOG41082F9 transcriptional regulator HTY60_03965 ENOG41061H0 Monooxygenase HTY60_03970 ENOG4108R1P HTY60_03975 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HTY60_03985 ENOG4105E0M Sulfatase HTY60_03990 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HTY60_04000 ENOG41090R9 glycosyltransferase HTY60_04005 ENOG4107R51 Glycosyl transferase, family 2 HTY60_04010 ENOG41090R9 glycosyltransferase HTY60_04015 ENOG4105EU0 Major facilitator Superfamily HTY60_04020 ENOG4105CUB amino acid HTY60_04025 ENOG4105C26 Dehydrogenase HTY60_04030 ENOG4105FKZ Methyl-accepting chemotaxis HTY60_04035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HTY60_04040 ENOG4107TVC Glycosyl transferase, family 2 HTY60_04045 ENOG4105C5H ABC transporter HTY60_04050 ENOG4107SWG transcriptional regulator MERR family HTY60_04055 ENOG4105DXB Major Facilitator superfamily HTY60_04060 ENOG4105C5H ABC transporter HTY60_04065 ENOG4105FDU atp-dependent rna helicase HTY60_04085 ENOG4108J20 pectate lyase HTY60_04090 ENOG4107QPK )-transporter HTY60_04115 ENOG4108NEV two component transcriptional regulator, LytTR family HTY60_04125 ENOG4108Z6X (sortase) family HTY60_04135 ENOG4108MRH transcriptional regulatory protein HTY60_04160 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) HTY60_04165 ENOG4108RPX mosc domain containing protein HTY60_04185 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HTY60_04230 ENOG4105CG3 alpha amylase, catalytic region HTY60_04235 ENOG4107414 GntR family transcriptional regulator HTY60_04240 ENOG4108RCM Nitroreductase HTY60_04255 ENOG4105CGH 5'-nucleotidase HTY60_04260 ENOG4107RKG DJ-1/PfpI family HTY60_04275 ENOG4105FF2 Type I DHQase HTY60_04290 ENOG4105KJF protein tyrosine phosphatase HTY60_04300 ENOG4107U9T Pfam:Ribonuclease_BN HTY60_04305 ENOG4108ISG Major Facilitator HTY60_04310 ENOG4105UPD Calcium Proton HTY60_04320 ENOG4105D8X mechanosensitive ion channel HTY60_04350 ENOG4105D7N magnesium and cobalt transport protein CorA HTY60_04360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HTY60_04370 ENOG4105BZ1 (ABC) transporter HTY60_04375 ENOG4105CJA serine threonine protein kinase HTY60_04395 ENOG4107RUY (E1 component), alpha subunit HTY60_04405 ENOG4107QKR Dehydrogenase HTY60_04415 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HTY60_04425 ENOG4105F8D glycoside hydrolase family 4 HTY60_04430 ENOG4108Q3X Transcriptional regulator HTY60_04435 ENOG4105CI1 PTS System HTY60_04445 ENOG4105BZ1 (ABC) transporter HTY60_04450 ENOG4105BZ1 (ABC) transporter HTY60_04460 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HTY60_04470 ENOG4105U3E Transcriptional regulator HTY60_04475 ENOG4105DYS nad(p)h dehydrogenase (quinone) HTY60_04480 ENOG4105H93 Acyltransferase family HTY60_04490 ENOG4108YYS metal-dependent hydrolase (By similarity) HTY60_04495 ENOG4105C0R drug resistance transporter emrb qaca subfamily HTY60_04500 ENOG410834F Transcriptional regulator HTY60_04510 ENOG4105JAB phenazine biosynthesis protein, phzf family HTY60_04515 ENOG4107Y03 Nitroreductase HTY60_04530 ENOG4105ECP epimerase HTY60_04535 ENOG410902V Modulates RecA activity (By similarity) HTY60_04555 ENOG4108TCS Glutamyl endopeptidase HTY60_04590 ENOG4105CKK Glycosyl transferase, family 2 HTY60_04595 ENOG4105EJV Membrane HTY60_04600 ENOG41067AE Membrane-bound metal-dependent hydrolase HTY60_04605 ENOG4105VTR Integrase HTY60_04645 ENOG4108ZUE Phage regulatory protein rha HTY60_04670 ENOG4105CDU Replicative dna helicase HTY60_04735 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HTY60_04850 ENOG4105CEN a g-specific adenine glycosylase HTY60_04855 ENOG4106BXE HTY60_04860 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HTY60_04880 ENOG4105BZ1 (ABC) transporter HTY60_04885 ENOG4107NBY Membrane HTY60_04890 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HTY60_04895 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HTY60_04900 ENOG4105G5W regulator Fur family HTY60_04905 ENOG4105TUA UPF0295 protein HTY60_05005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HTY60_05170 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HTY60_05175 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HTY60_05190 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HTY60_05200 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HTY60_05205 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HTY60_05260 ENOG4108J9Q DNA ligase HTY60_05400 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HTY60_05415 ENOG41068G1 HTY60_05435 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HTY60_05475 ENOG4105EC3 peptidase S51, dipeptidase E HTY60_05480 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HTY60_05485 ENOG4105DNP FAD linked oxidase domain protein HTY60_05495 ENOG4105DEF Extracellular solute-binding protein, family 5 HTY60_05505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HTY60_05510 ENOG4105C3U ABC transporter HTY60_05530 ENOG4105E2Y ABC, transporter HTY60_05535 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HTY60_05540 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HTY60_05555 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HTY60_05560 ENOG4107D63 HTY60_05565 ENOG4105VZ8 Transcriptional regulator HTY60_05580 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HTY60_05590 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HTY60_05610 ENOG4105CYN Serine protein kinase HTY60_05620 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HTY60_05625 ENOG4105CW7 secretion protein, HlyD family HTY60_05630 ENOG4105C0R drug resistance transporter emrb qaca subfamily HTY60_05635 ENOG4105CS1 NAD(P)H quinone oxidoreductase HTY60_05650 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HTY60_05655 ENOG4105CZV ABC transporter HTY60_05660 ENOG4105CJ1 ABC, transporter HTY60_05665 ENOG4108TU7 Inherit from COG: (ABC) transporter HTY60_05670 ENOG4105VEQ Cold shock protein HTY60_05680 ENOG4105BZU Histidine kinase HTY60_05690 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HTY60_05725 ENOG4108YBP pseudouridine synthase HTY60_05735 ENOG41080XP Cbs domain HTY60_05740 ENOG4107YBY Hydrolase HTY60_05745 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HTY60_05750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HTY60_05755 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HTY60_05765 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HTY60_05770 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HTY60_05780 ENOG4105BZU Histidine kinase HTY60_05785 ENOG4105WH1 Two component transcriptional regulator luxr family HTY60_05820 ENOG4105ED1 spovr family HTY60_05825 ENOG4105G6Z alkaline phosphatase HTY60_05840 ENOG4105BZN citrate synthase HTY60_05845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HTY60_05850 ENOG4105CUB amino acid HTY60_05855 ENOG4105C8J )-transporter HTY60_05865 ENOG4105J37 HTY60_05870 ENOG4108AEY RNA polymerase sigma factor HTY60_05875 ENOG4105F6E Acyl-transferase HTY60_05880 ENOG4105C37 (CBS) domain HTY60_05890 ENOG4105CHM Aminotransferase HTY60_05895 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HTY60_05900 ENOG4105C37 (CBS) domain HTY60_05910 ENOG4105WMR Protein CrcB homolog HTY60_05915 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HTY60_05925 ENOG4105D64 Mechanosensitive ion channel HTY60_05930 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HTY60_05935 ENOG4107VMI polysaccharide deacetylase HTY60_05940 ENOG4105F0I Aminotransferase HTY60_05945 ENOG4105W1N transcriptional regulator HTY60_05950 ENOG4105IIP Membrane HTY60_05960 ENOG4105BZ1 (ABC) transporter HTY60_05965 ENOG4105BZ1 (ABC) transporter HTY60_05985 ENOG410839P HTY60_05995 ENOG4106MP8 UPF0754 membrane protein HTY60_06000 ENOG4105WZB UPF0342 protein HTY60_06010 ENOG4105D4P Coproporphyrinogen iii oxidase HTY60_06020 ENOG4107S91 Sodium hydrogen exchanger HTY60_06025 ENOG4105NCW Trka-c domain protein HTY60_06035 ENOG4105CGU Enoyl-CoA hydratase HTY60_06045 ENOG4108IUX (ABC) transporter HTY60_06050 ENOG4105RHA ABC transporter, permease HTY60_06055 ENOG4107VRP DNA repair exonuclease HTY60_06065 ENOG4105EQI Metal Dependent Phosphohydrolase HTY60_06075 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HTY60_06120 ENOG4105NBU tryptophan transport protein HTY60_06125 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HTY60_06130 ENOG4105K59 histidine triad (HIT) protein HTY60_06160 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HTY60_06165 ENOG4105BZ4 penicillin-binding protein HTY60_06170 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HTY60_06175 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HTY60_06180 ENOG4105C1Q protoporphyrinogen oxidase HTY60_06190 ENOG4105ECB domain protein HTY60_06205 ENOG4105DER m42 family HTY60_06215 ENOG4106AXD HTY60_06220 ENOG4108RQ5 Beta-lactamase domain-containing protein HTY60_06225 ENOG4105DF9 Lipoate-protein, ligase HTY60_06235 ENOG4105CEY Amp-dependent synthetase and ligase HTY60_06245 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HTY60_06255 ENOG4108HUF Transporter HTY60_06260 ENOG4107TB6 phosphoglycerate mutase HTY60_06275 ENOG4107ZYJ bioY protein HTY60_06300 ENOG4105XVF Competence transcription factor HTY60_06305 ENOG4108ZMX Domain of unknown function (DU1801) HTY60_06320 ENOG4105X3H Excalibur domain protein HTY60_06325 ENOG4105K8R UPF0145 protein HTY60_06330 ENOG4105E1V na solute symporter HTY60_06335 ENOG4106CAD Protein of unknown function (DUF3311) HTY60_06340 ENOG41060YP HTY60_06355 ENOG4107SCK Monooxygenase HTY60_06360 ENOG4108INS Transcriptional regulator HTY60_06365 ENOG4108KK1 membrane protein AbrB duplication HTY60_06375 ENOG4108IG5 Transcriptional regulator HTY60_06385 ENOG4108QY0 Membrane HTY60_06390 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HTY60_06395 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HTY60_06405 ENOG4105EYH Exonuclease HTY60_06450 ENOG4105ERH Fumarylacetoacetate hydrolase HTY60_06460 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HTY60_06470 ENOG4105CAQ asparagine synthetase HTY60_06480 ENOG4105UQX Mate efflux family protein HTY60_06485 ENOG4106HBX Transcriptional Regulator AraC Family HTY60_06490 ENOG4105ETE Transcriptional regulator (LacI family HTY60_06495 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HTY60_06500 ENOG4105SF0 DinB family HTY60_06505 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HTY60_06510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HTY60_06515 ENOG4105MYW Pentapeptide repeat protein HTY60_06520 ENOG4105MA6 gCN5-related N-acetyltransferase HTY60_06530 ENOG4108VPT UPF0234 protein HTY60_06535 ENOG4105QNR S1 RNA binding domain protein HTY60_06540 ENOG4105DIH basic membrane HTY60_06545 ENOG4105C8Q Methyl-accepting chemotaxis HTY60_06555 ENOG4105EPR degv family HTY60_06560 ENOG4107AYK membrAne HTY60_06570 ENOG41073B9 HTY60_06580 ENOG4108KP7 hydrolase HTY60_06585 ENOG4108MXZ Esterase HTY60_06590 ENOG4105VG1 fes assembly suf system protein HTY60_06595 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HTY60_06600 ENOG4105IQ5 FAD linked oxidase domain protein HTY60_06610 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HTY60_06615 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HTY60_06620 ENOG4105CAS nag kinase HTY60_06625 ENOG4105C8Y Acetylornithine aminotransferase HTY60_06630 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HTY60_06640 ENOG4105DBV ornithine carbamoyltransferase HTY60_06665 ENOG4107RMD Basic membrane lipoprotein HTY60_06680 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HTY60_06685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HTY60_06695 ENOG4105C3U ABC transporter HTY60_06700 ENOG4108JQ7 (ABC) transporter HTY60_06715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HTY60_06725 ENOG4105C31 Tryptophanyl-tRNA synthetase HTY60_06730 ENOG4108J59 Extracellular solute-binding protein, family 5 HTY60_06735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HTY60_06740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HTY60_06750 ENOG4108JQ7 (ABC) transporter HTY60_06765 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HTY60_06770 ENOG4108ZCF integral membrane protein HTY60_06780 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HTY60_06790 ENOG4105DPN Oligoendopeptidase f HTY60_06800 ENOG4105T58 Dithiol-disulfide isomerase HTY60_06805 ENOG4108Z18 K06886 hemoglobin HTY60_06810 ENOG4105E4C Lytic transglycosylase catalytic HTY60_06815 ENOG4105MIX Adenylate cyclase HTY60_06830 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HTY60_06835 ENOG4105EMS pseudouridine synthase HTY60_06840 ENOG4107S1Q Phosphatase HTY60_06850 ENOG4105ETU transcriptional activator (TenA HTY60_06855 ENOG4108VEU Thiamine monophosphate synthase HTY60_06875 ENOG4105D06 uba thif-type nad fad binding protein HTY60_06880 ENOG4105DWF phosphomethylpyrimidine kinase HTY60_06885 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HTY60_06890 ENOG4107A88 HTY60_06940 ENOG4105ENA helicase HTY60_06960 ENOG4105CJ1 ABC, transporter HTY60_06975 ENOG4108ZMI UPF0477 protein HTY60_06985 ENOG4105C28 cystathionine HTY60_06990 ENOG4105C28 cystathionine HTY60_07045 ENOG4105DB4 HTY60_07065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HTY60_07115 ENOG4105C0R drug resistance transporter emrb qaca subfamily HTY60_07130 ENOG4105CK1 PTS System HTY60_07135 ENOG4105VCP PTS System HTY60_07140 ENOG4105CS2 ec 3.2.1.21 HTY60_07145 ENOG4105E98 transcriptional regulator DeoR family HTY60_07165 ENOG4105KT7 mgtC SapB transporter HTY60_07195 ENOG4105C4B ABC transporter, permease HTY60_07200 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HTY60_07210 ENOG41087PP glycosyltransferase MGT family HTY60_07215 ENOG4106A3M Cytochrome p-450 HTY60_07240 ENOG4105Q95 Cupin 2, conserved barrel domain protein HTY60_07260 ENOG4107KJX Transcriptional regulator HTY60_07270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HTY60_07275 ENOG4105BZU Histidine kinase HTY60_07290 ENOG4107TSN permease HTY60_07310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HTY60_07315 ENOG4105KWG Pfam:DUF1696 HTY60_07320 ENOG4105K7W phage-related replication protein HTY60_07325 ENOG410635T phage-like element pbsx protein HTY60_07370 ENOG4108TFU terminase (Small subunit) HTY60_07375 ENOG4105IG6 Phage terminase, large subunit HTY60_07380 ENOG4108MDF Phage Portal Protein HTY60_07405 ENOG41060SN HTY60_07420 ENOG4105PQS phage protein HTY60_07425 ENOG4105FR7 XkdM protein, phage-like element PBSX HTY60_07430 ENOG4105MTC XkdN-like protein HTY60_07440 ENOG4108FKH Transglycosylase SLT domain HTY60_07440 ENOG4108FKH Transglycosylase SLT domain HTY60_07440 ENOG4108FKH Transglycosylase SLT domain HTY60_07445 ENOG4108WZM domain protein HTY60_07450 ENOG4105X7F HTY60_07460 ENOG4105MFU Protein of unknown function (DUF2634) HTY60_07465 ENOG41066EA baseplate J family protein HTY60_07470 ENOG410906S phage-like element pbsx protein xkdt HTY60_07490 ENOG41068G1 HTY60_07520 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HTY60_07535 ENOG4105CJ3 phosphate transporter HTY60_07540 ENOG4107GRR phosphate transport regulator HTY60_07545 ENOG4107R7I amino acid HTY60_07555 ENOG4105EDW glycosyl transferase, family 39 HTY60_07560 ENOG4105CKK Glycosyl transferase, family 2 HTY60_07570 ENOG4105C0H protease HTY60_07580 ENOG4108ME1 Peptidase M55 D-aminopeptidase HTY60_07585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HTY60_07590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HTY60_07595 ENOG4105C3U ABC transporter HTY60_07605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HTY60_07610 ENOG4105DTQ mandelate racemase muconate lactonizing HTY60_07615 ENOG4107SN7 NLP P60 protein HTY60_07620 ENOG4108JQ7 (ABC) transporter HTY60_07625 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HTY60_07630 ENOG4107TUM Amidinotransferase HTY60_07635 ENOG4108S4H thioesterase Superfamily protein HTY60_07640 ENOG4108428 Inherit from COG: -acetyltransferase HTY60_07650 ENOG41080TC multidrug resistance protein HTY60_07655 ENOG4105CIY formyltetrahydrofolate deformylase HTY60_07660 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HTY60_07675 ENOG4105K56 Transcriptional regulator HTY60_07680 ENOG4108ZHJ Organic hydroperoxide resistance protein HTY60_07695 ENOG4107TVC Glycosyl transferase, family 2 HTY60_07710 ENOG4105D8G Major Facilitator superfamily HTY60_07715 ENOG4108Y4K DNA-binding transcriptional activator HTY60_07720 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HTY60_07725 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HTY60_07735 ENOG4108W7F transporter, permease HTY60_07740 ENOG4108JJB ABC transporter HTY60_07745 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HTY60_07750 ENOG4105VRS hydrolase family 18 HTY60_07760 ENOG4105CJW magnesium transporter HTY60_07765 ENOG4105V75 Transcriptional regulator HTY60_07790 ENOG4105DQE DNA ligase HTY60_07795 ENOG4105FDF Could be involved in DNA repair (By similarity) HTY60_07800 ENOG4105BZU Histidine kinase HTY60_07805 ENOG4107T5V SNARE associated Golgi HTY60_07810 ENOG4107TS3 membrane protein, TerC HTY60_07815 ENOG4108WZW RNA polymerase sigma HTY60_07825 ENOG410681C small acid-soluble spore protein HTY60_07835 ENOG4105D0M Protease HtpX homolog HTY60_07845 ENOG410900G Protein of unknown function (DUF421) HTY60_07855 ENOG4108TGC Acyltransferase HTY60_07860 ENOG4105BZU Histidine kinase HTY60_07865 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HTY60_07870 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HTY60_07880 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HTY60_07890 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HTY60_07895 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HTY60_07900 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HTY60_07905 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HTY60_07915 ENOG4105BZU Histidine kinase HTY60_07920 ENOG41090MY MarR family Transcriptional regulator HTY60_07925 ENOG4105ER2 Ompa motb domain protein HTY60_07930 ENOG4105E14 MotA TolQ exbB proton channel HTY60_07940 ENOG4108K88 Membrane HTY60_07955 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HTY60_07960 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HTY60_07965 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HTY60_07970 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HTY60_07990 ENOG4105F0V Cell wall hydrolase HTY60_08005 ENOG4105C59 p-type ATPase HTY60_08010 ENOG4105DC7 peptidase M24 HTY60_08030 ENOG4105KRI phosphocarrier protein (HPr HTY60_08035 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HTY60_08045 ENOG4105F6S Spore photoproduct lyase HTY60_08050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HTY60_08055 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HTY60_08065 ENOG4105K4I Scp-like extracellular HTY60_08075 ENOG4105BZU Histidine kinase HTY60_08080 ENOG4105CHM Aminotransferase HTY60_08090 ENOG4107R88 Chemotaxis protein (CheV) HTY60_08095 ENOG4105UIN HTY60_08105 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HTY60_08115 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HTY60_08125 ENOG4105EPM Diguanylate phosphodiesterase HTY60_08130 ENOG4107IN1 Protein of unknown function (DUF1797) HTY60_08135 ENOG4108XRC Protein of unknown function (DUF458) HTY60_08165 ENOG4105NQC Flavodoxin HTY60_08185 ENOG4105D8X mechanosensitive ion channel HTY60_08210 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HTY60_08215 ENOG4105D06 uba thif-type nad fad binding protein HTY60_08220 ENOG4105CVM Molybdenum cofactor synthesis domain protein HTY60_08225 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HTY60_08230 ENOG4108ZAF Molybdopterin HTY60_08235 ENOG41067WU Molybdopterin converting factor (Subunit 1) HTY60_08245 ENOG4107X8C Efflux transporter RND family MFP subunit HTY60_08250 ENOG4105C19 ABC transporter HTY60_08255 ENOG4107RBB ABC transporter, permease HTY60_08260 ENOG4105E98 transcriptional regulator DeoR family HTY60_08265 ENOG4105DE4 1-phosphofructokinase HTY60_08270 ENOG4105DM4 PTS System HTY60_08285 ENOG4105C5H ABC transporter HTY60_08290 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HTY60_08315 ENOG4105BZU Histidine kinase HTY60_08325 ENOG4107ZYR domain protein HTY60_08330 ENOG4105CPN adenine deaminase HTY60_08335 ENOG4105CN5 Metallo-Beta-Lactamase HTY60_08340 ENOG4106148 UPF0356 protein HTY60_08345 ENOG4108X4Q Hydrolase HTY60_08350 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HTY60_08370 ENOG4105CPP Dehydrogenase, E1 component HTY60_08375 ENOG4105C7S Dehydrogenase HTY60_08380 ENOG4107QN2 dihydrolipoyl dehydrogenase HTY60_08400 ENOG4105CXN decarboxylase HTY60_08405 ENOG4105WBI UPF0223 protein HTY60_08420 ENOG4105ECY inositol monophosphatase HTY60_08430 ENOG4105D4Y metalloprotease HTY60_08450 ENOG4105CI3 gtp-binding protein typa HTY60_08455 ENOG4105QA2 HTY60_08470 ENOG4108IAB Phoh family HTY60_08480 ENOG4105CSV Glutaminase HTY60_08490 ENOG4105CNI cell division protein FtsW HTY60_08495 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HTY60_08505 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HTY60_08515 ENOG4105BZ9 Cytochrome C oxidase, subunit I HTY60_08520 ENOG4105CCU oxidase (Subunit III) HTY60_08525 ENOG41064X9 cytochrome C oxidase subunit IV HTY60_08540 ENOG41080XQ Signal transduction protein with cbs domains HTY60_08545 ENOG4106UY4 Inherit from COG: Scp-like extracellular HTY60_08570 ENOG4106H78 methyltransferase HTY60_08575 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HTY60_08580 ENOG4105H20 Sporulation integral membrane protein YlbJ HTY60_08585 ENOG4105D78 K07001 NTE family protein HTY60_08590 ENOG41063PX domain protein HTY60_08595 ENOG4105CDE UPF0348 protein HTY60_08600 ENOG4105KNH Nucleic acid-binding protein HTY60_08630 ENOG4108V6E Cell division protein mraZ HTY60_08635 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HTY60_08645 ENOG4105CJN penicillin-binding protein HTY60_08650 ENOG4105CJN penicillin-binding protein HTY60_08655 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HTY60_08660 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HTY60_08665 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HTY60_08670 ENOG4105CNI cell division protein FtsW HTY60_08675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HTY60_08680 ENOG4105D4A Cell wall formation (By similarity) HTY60_08685 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HTY60_08690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HTY60_08695 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HTY60_08705 ENOG4105FFI sigma-e processing peptidase spoiiga HTY60_08710 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_08720 ENOG4105DKW ABC transporter HTY60_08730 ENOG4105WR5 sporulation protein, YlmC YmxH family HTY60_08735 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HTY60_08740 ENOG4105DFA alanine racemase domain protein HTY60_08745 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HTY60_08750 ENOG41067XK integral membrane protein HTY60_08755 ENOG4105DBK s4 domain protein HTY60_08765 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HTY60_08775 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HTY60_08780 ENOG4105C34 Pseudouridine synthase HTY60_08785 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HTY60_08795 ENOG4105CXT aspartate transcarbamylase HTY60_08805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HTY60_08810 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HTY60_08815 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HTY60_08820 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HTY60_08825 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HTY60_08830 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HTY60_08845 ENOG4107RIQ Sulfate adenylate transferase HTY60_08855 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HTY60_08860 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HTY60_08865 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HTY60_08885 ENOG4105DSJ YicC domain protein HTY60_08890 ENOG4105KC4 UPF0296 protein HTY60_08895 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HTY60_08905 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HTY60_08910 ENOG4105C25 Primosomal protein n' HTY60_08915 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HTY60_08920 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HTY60_08925 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HTY60_08930 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HTY60_08935 ENOG4108ZF3 Phosphatase HTY60_08940 ENOG4105D9P serine threonine protein kinase HTY60_08945 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HTY60_08950 ENOG4105DJV ribulose-phosphate 3-epimerase HTY60_08955 ENOG4105FJ0 thiamine HTY60_08965 ENOG4105VB9 50S ribosomal protein l28 HTY60_08970 ENOG4108ZAA Alkaline-shock protein HTY60_08975 ENOG4105DP4 dak2 domain fusion protein ylov HTY60_08985 ENOG4105EJQ L-serine dehydratase HTY60_08990 ENOG4105CB5 ATP-dependent DNA helicase recG HTY60_08995 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HTY60_09000 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HTY60_09005 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HTY60_09010 ENOG4105CHR reductase HTY60_09020 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HTY60_09025 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HTY60_09030 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HTY60_09035 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HTY60_09045 ENOG4105K5M 30s ribosomal protein S16 HTY60_09050 ENOG4108BW8 UPF0109 protein HTY60_09065 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HTY60_09070 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HTY60_09075 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HTY60_09080 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HTY60_09090 ENOG4105VM1 flagellar HTY60_09095 ENOG4105CMV Succinyl-CoA synthetase subunit beta HTY60_09100 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HTY60_09105 ENOG4105C79 DNA protecting protein DprA HTY60_09110 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HTY60_09115 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HTY60_09120 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HTY60_09125 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HTY60_09130 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HTY60_09140 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HTY60_09145 ENOG4108ZC9 flagellar basal-body rod protein flgc HTY60_09150 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HTY60_09155 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HTY60_09160 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HTY60_09175 ENOG4106YF4 Flagellar biosynthesis chaperone HTY60_09185 ENOG410696Y Flagellar hook-length control protein HTY60_09190 ENOG410822I Flagellar hook capping protein HTY60_09195 ENOG4108JQA flagellar HTY60_09200 ENOG41068WV flagellar FlbD family protein HTY60_09210 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HTY60_09215 ENOG4105DD5 Flagellar motor switch protein HTY60_09220 ENOG4107YTP response regulator receiver protein HTY60_09230 ENOG4105CN7 Flagellar biosynthetic protein FliP HTY60_09235 ENOG4105VS8 Flagellar biosynthetic protein fliq HTY60_09240 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HTY60_09245 ENOG4105D00 flagellar biosynthetic protein flhB HTY60_09250 ENOG4105D7B Flagellar biosynthesis protein flha HTY60_09255 ENOG4105FZW flagellar biosynthesis regulator FlhF HTY60_09270 ENOG4105CBS Chea signal transduction histidine kinase HTY60_09275 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HTY60_09285 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HTY60_09290 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_09300 ENOG4105CE9 30S ribosomal protein S2 HTY60_09310 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HTY60_09315 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HTY60_09320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HTY60_09325 ENOG4105KNE Phosphatidate cytidylyltransferase HTY60_09335 ENOG4105DZP Membrane-associated zinc metalloprotease HTY60_09340 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HTY60_09345 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HTY60_09350 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HTY60_09355 ENOG4105CHV Transcription elongation factor NusA HTY60_09360 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HTY60_09365 ENOG4105VHM ribosomal protein HTY60_09370 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HTY60_09375 ENOG4105W7A Protein of unknown function (DUF503) HTY60_09380 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HTY60_09385 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HTY60_09390 ENOG4105DTN riboflavin biosynthesis protein ribF HTY60_09395 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HTY60_09400 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HTY60_09410 ENOG4105C1V Peptidase, M16 HTY60_09420 ENOG4105E35 Dipicolinate synthase subunit A HTY60_09425 ENOG4108S0H Dipicolinic acid synthetase, b subunit HTY60_09430 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HTY60_09440 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HTY60_09450 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HTY60_09460 ENOG4105CNU cell division protein FtsK HTY60_09465 ENOG4105FDP GntR family transcriptional regulator HTY60_09480 ENOG4105EYF MMPL domain protein HTY60_09495 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HTY60_09500 ENOG4105XZV Protein of unknown function (DUF3243) HTY60_09515 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HTY60_09520 ENOG4105CEV competence damage-inducible protein HTY60_09525 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HTY60_09530 ENOG4108A04 Beta-lactamase HTY60_09540 ENOG4105D48 metallophosphoesterase HTY60_09545 ENOG4105MCT stage V sporulation protein S HTY60_09550 ENOG4105CPQ Dehydrogenase HTY60_09555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HTY60_09560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HTY60_09580 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HTY60_09585 ENOG4108151 Beta-lactamase domain protein HTY60_09590 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HTY60_09595 ENOG4108JA1 polyketide synthase HTY60_09600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HTY60_09605 ENOG41062T2 Acyl carrier protein HTY60_09610 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HTY60_09615 ENOG4108MGH Enoyl-CoA hydratase HTY60_09620 ENOG4108KQ6 Enoyl-CoA hydratase HTY60_09625 ENOG4105C0W non-ribosomal peptide synthetase HTY60_09630 ENOG4107SQU synthase HTY60_09640 ENOG4105C0W non-ribosomal peptide synthetase HTY60_09650 ENOG4106A3M Cytochrome p-450 HTY60_09655 ENOG4105WFK nuclease HTY60_09660 ENOG4105XPP Protein of unknown function (DUF1275) HTY60_09670 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HTY60_09680 ENOG4105K7W phage-related replication protein HTY60_09685 ENOG4108X3M OsmC Ohr family protein HTY60_09710 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HTY60_09735 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HTY60_09740 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HTY60_09745 ENOG4105U6W MutT NUDIX family protein HTY60_09755 ENOG4106F1P AAA ATPase, central domain protein HTY60_09760 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HTY60_09765 ENOG4105CXI aluminum resistance protein HTY60_09770 ENOG4105KV4 Transcriptional regulator HTY60_09775 ENOG4105C5F glutamine synthetase HTY60_09780 ENOG4105VTR Integrase HTY60_09790 ENOG4107Y9E nuclease HTY60_09805 ENOG4106BHF HTY60_09810 ENOG4106ANW SMI1_KNR4 HTY60_09825 ENOG4108YTE sporulation protein YunB HTY60_09835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HTY60_09845 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HTY60_09865 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HTY60_09885 ENOG410780I phosphoprotein phosphatase activity HTY60_09920 ENOG41090VF Stage v sporulation protein ac HTY60_09925 ENOG4105CZ3 stage V sporulation protein ad HTY60_09940 ENOG4108QY0 Membrane HTY60_09950 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HTY60_09955 ENOG4105H67 Protein of unknown function (DUF421) HTY60_09960 ENOG4108UB7 HTY60_09985 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HTY60_09990 ENOG4105C5Q Transcriptional regulator HTY60_09995 ENOG4105CBC glutamate synthase HTY60_10000 ENOG4105BZ8 glutamate synthase HTY60_10005 ENOG4105C22 threonyL-tRNA synthetase HTY60_10010 ENOG4105WAB arsR family transcriptional regulator HTY60_10015 ENOG4108RWP Major Facilitator Superfamily protein HTY60_10020 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HTY60_10045 ENOG4107QJQ Mate efflux family protein HTY60_10050 ENOG4108N2V aldose 1-epimerase HTY60_10055 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HTY60_10060 ENOG4105CEY Amp-dependent synthetase and ligase HTY60_10070 ENOG4106U2H Protein of unknown function (DUF1360) HTY60_10075 ENOG4105F32 YngK protein HTY60_10080 ENOG4105C1G acyl-Coa dehydrogenase HTY60_10090 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HTY60_10095 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HTY60_10100 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HTY60_10105 ENOG4105E39 Enoyl-CoA hydratase HTY60_10110 ENOG4107QX3 carboxylase HTY60_10115 ENOG4107T5V SNARE associated Golgi HTY60_10120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HTY60_10135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HTY60_10140 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HTY60_10145 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HTY60_10150 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HTY60_10160 ENOG4105D6N CoA-transferase, subunit a HTY60_10165 ENOG4108IIH CoA-transferase subunit B HTY60_10170 ENOG4105DTD Dehydrogenase HTY60_10195 ENOG4107SYN Glycosyl hydrolases family 43 HTY60_10205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HTY60_10220 ENOG4105FVX HTY60_10255 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HTY60_10260 ENOG4105K4P CoA-binding domain protein HTY60_10265 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HTY60_10270 ENOG4105W8X HesB YadR YfhF-family protein HTY60_10275 ENOG4105MI2 HTY60_10285 ENOG41067CD Small, acid-soluble spore protein Tlp HTY60_10300 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HTY60_10305 ENOG4108I0Z Aconitate hydratase HTY60_10340 ENOG4107QIV Cytochrome c biogenesis protein HTY60_10350 ENOG4105VXM UPF0154 protein HTY60_10360 ENOG4105CV1 Transketolase (EC 2.2.1.1) HTY60_10365 ENOG4105VPS UPF0291 protein HTY60_10370 ENOG4108SVB resolvase HTY60_10380 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HTY60_10405 ENOG4105K7W phage-related replication protein HTY60_10415 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HTY60_10420 ENOG4105YB8 TM2 domain containing protein HTY60_10445 ENOG4108M1A Chitin-binding protein HTY60_10480 ENOG4105EPI acetyltransferase, (GNAT) family HTY60_10500 ENOG4105DQ4 alcohol dehydrogenase HTY60_10515 ENOG4105H67 Protein of unknown function (DUF421) HTY60_10520 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HTY60_10530 ENOG4108QY0 Membrane HTY60_10545 ENOG4105CZ3 stage V sporulation protein ad HTY60_10550 ENOG41090VF Stage v sporulation protein ac HTY60_10585 ENOG4105IE8 Alpha-ketoglutarate permease HTY60_10590 ENOG4107U6E carbohydrate kinase FGGY HTY60_10600 ENOG4108J2R molybdopterin oxidoreductase HTY60_10630 ENOG4108Z7R Chaperone CsaA HTY60_10635 ENOG4105FTV AraC Family Transcriptional Regulator HTY60_10645 ENOG4108W8B Beta-lactamase domain protein HTY60_10655 ENOG4105KTU Transcriptional regulator, arsr family HTY60_10665 ENOG4108SJC Membrane HTY60_10690 ENOG41069ER domain protein HTY60_10695 ENOG4105C9U ATP-dependent DNA helicase RecQ HTY60_10705 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HTY60_10710 ENOG4105SCY DNAK suppressor HTY60_10755 ENOG4105C26 Dehydrogenase HTY60_10760 ENOG4105EWU Squalene--hopene cyclase HTY60_10765 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HTY60_10770 ENOG4105C8J )-transporter HTY60_10775 ENOG4105C09 Bile acid HTY60_10785 ENOG4105C7S Dehydrogenase HTY60_10790 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HTY60_10795 ENOG4107T89 von Willebrand factor, type A HTY60_10800 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HTY60_10815 ENOG41087PP glycosyltransferase MGT family HTY60_10825 ENOG4107QMU Mate efflux family protein HTY60_10830 ENOG4106SCS STAS domain HTY60_10850 ENOG4105FR1 rard protein HTY60_10865 ENOG41090U3 tautomerase HTY60_10895 ENOG4105E1V na solute symporter HTY60_10905 ENOG4105CS2 ec 3.2.1.21 HTY60_10910 ENOG4108S3Y transcriptional regulator HTY60_10930 ENOG4108VXD carboxy-peptidase HTY60_10935 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HTY60_10945 ENOG4106Z5R HTY60_10950 ENOG410841Q phosphoesterase PA-phosphatase related protein HTY60_10970 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HTY60_10985 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HTY60_10990 ENOG4108TSC N-acetyltransferase HTY60_10995 ENOG4107S4Y M20 DapE family protein YgeY HTY60_11010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HTY60_11015 ENOG4105FTQ Dna gyrase HTY60_11055 ENOG4105C5E polysaccharide biosynthesis protein HTY60_11065 ENOG4105DMF Dehydrogenase HTY60_11085 ENOG4105C5E polysaccharide biosynthesis protein HTY60_11090 ENOG4105E0X reductase HTY60_11095 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HTY60_11105 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HTY60_11110 ENOG41090WU lipolytic protein G-D-S-L family HTY60_11115 ENOG4108KF3 Electron transport protein SCO1 SenC HTY60_11125 ENOG4105C7B Threonine dehydratase HTY60_11135 ENOG4108UT2 hemolysin iii HTY60_11145 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HTY60_11150 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HTY60_11160 ENOG4107YX5 Pfam:DUF548 HTY60_11165 ENOG4108Y6J UPF0403 protein HTY60_11170 ENOG4105C01 Dihydroxy-acid dehydratase HTY60_11185 ENOG4108V06 Glutathione peroxidase HTY60_11190 ENOG4105CVG Homoserine O-transsuccinylase HTY60_11235 ENOG41081VK Ribonuclease HTY60_11260 ENOG410890F Dynamin family HTY60_11275 ENOG41065KQ synthase HTY60_11295 ENOG4105C2W permease HTY60_11300 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HTY60_11310 ENOG4105DVT helicase HTY60_11330 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HTY60_11340 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HTY60_11345 ENOG4108UKS UPF0398 protein HTY60_11360 ENOG4107X2U Inherit from COG: Exonuclease-like protein HTY60_11365 ENOG4108I5C dEAD DEAH box helicase HTY60_11410 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HTY60_11415 ENOG4105BZ4 penicillin-binding protein HTY60_11425 ENOG4105CSM endonuclease III HTY60_11435 ENOG4105C5S asparaginyl-tRNA synthetase HTY60_11440 ENOG4105CHM Aminotransferase HTY60_11450 ENOG4105YAC HTY60_11455 ENOG4105DVT helicase HTY60_11460 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HTY60_11470 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HTY60_11480 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HTY60_11485 ENOG4105CPK Glycosyl transferase (Group 1 HTY60_11490 ENOG4105FJR Lmbe family HTY60_11495 ENOG4108Z5K methylglyoxal synthase HTY60_11500 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HTY60_11505 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HTY60_11510 ENOG4108JYZ YitT family HTY60_11515 ENOG4105F0F Oxalate decarboxylase HTY60_11535 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HTY60_11555 ENOG41068YB TPR repeat-containing protein HTY60_11560 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HTY60_11570 ENOG4105CIH Imidazole acetol-phosphate transaminase HTY60_11580 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HTY60_11585 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HTY60_11590 ENOG4105DK0 Indole-3-glycerol phosphate synthase HTY60_11600 ENOG4105CRQ synthase (Component I) HTY60_11605 ENOG4105KHN chorismate mutase HTY60_11615 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HTY60_11620 ENOG4105BZU Histidine kinase HTY60_11625 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HTY60_11630 ENOG4105EAH synthase HTY60_11635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HTY60_11640 ENOG4105XXQ heptaprenyl diphosphate synthase component I HTY60_11645 ENOG4105WP2 Tryptophan RNA-binding attenuator protein HTY60_11650 ENOG4105EUJ GTP cyclohydrolase i HTY60_11655 ENOG4105K70 DNA-binding protein HTY60_11660 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HTY60_11675 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HTY60_11680 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HTY60_11700 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HTY60_11705 ENOG4105CAT Cytidine monophosphate kinase HTY60_11720 ENOG4105MSI germination protein ypeb HTY60_11730 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HTY60_11735 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HTY60_11750 ENOG4107RGJ metallophosphoesterase HTY60_11765 ENOG4105I7S Abortive infection protein HTY60_11770 ENOG4105C9U ATP-dependent DNA helicase RecQ HTY60_11775 ENOG4105T7X HTY60_11785 ENOG4108SAX Membrane HTY60_11790 ENOG4108JQ1 Dehydrogenase HTY60_11805 ENOG4105BZU Histidine kinase HTY60_11810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HTY60_11815 ENOG4105CRE cytochrome C HTY60_11820 ENOG4107TWT Cytochrome c biogenesis protein HTY60_11830 ENOG4105FE9 pseudouridine synthase HTY60_11840 ENOG4108JIC nucleoside recognition domain protein HTY60_11845 ENOG4105DZ1 carboxypeptidase HTY60_11855 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HTY60_11860 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HTY60_11880 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HTY60_11885 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HTY60_11890 ENOG4108R6K riboflavin synthase, subunit alpha HTY60_11915 ENOG4107ZE5 PPIases accelerate the folding of proteins HTY60_11920 ENOG4105PTM secreted protein HTY60_11925 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HTY60_11935 ENOG4105G6R Stage v sporulation protein ae HTY60_11945 ENOG4105CZ3 stage V sporulation protein ad HTY60_11950 ENOG41090VF Stage v sporulation protein ac HTY60_11965 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_11970 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HTY60_11975 ENOG41082AN stage II sporulation protein HTY60_11980 ENOG4105DZ1 carboxypeptidase HTY60_11985 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HTY60_11990 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HTY60_11995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HTY60_12005 ENOG4105I3K Ferric uptake regulator, Fur family HTY60_12010 ENOG4105MZ9 stage II sporulation protein m HTY60_12030 ENOG4105DFD Na H antiporter HTY60_12035 ENOG4108IJ0 Aspartate ammonia-lyase HTY60_12040 ENOG4105HDK L-asparaginase HTY60_12045 ENOG4108IMY Transcriptional regulator HTY60_12055 ENOG4108YZ4 nudix hydrolase HTY60_12065 ENOG4105CPC Aldo Keto reductase HTY60_12085 ENOG4106HZJ HTY60_12090 ENOG4105RHY Pfam:UPF0157 HTY60_12095 ENOG4108XET gCN5-related N-acetyltransferase HTY60_12100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HTY60_12115 ENOG4105C02 permease HTY60_12125 ENOG4105CS9 pantothenic acid kinase HTY60_12135 ENOG4108IXY short-chain dehydrogenase reductase HTY60_12140 ENOG41069FQ Metallo-beta-lactamase superfamily HTY60_12145 ENOG4105II7 pyrroline-5-carboxylate reductase HTY60_12150 ENOG4108K70 Transcriptional regulator HTY60_12170 ENOG410861F 50S ribosomal protein L33 HTY60_12175 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HTY60_12180 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HTY60_12185 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HTY60_12190 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HTY60_12200 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HTY60_12205 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HTY60_12215 ENOG4108ZVT methylmalonyl-coA epimerase HTY60_12225 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HTY60_12230 ENOG4108QEG Membrane HTY60_12235 ENOG4105CDA abc transporter atp-binding protein HTY60_12240 ENOG4105E5Q amino acid AbC transporter HTY60_12245 ENOG4108HW3 (ABC) transporter HTY60_12250 ENOG4108Y6J UPF0403 protein HTY60_12255 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HTY60_12260 ENOG4105C7S Dehydrogenase HTY60_12265 ENOG4105CPP Dehydrogenase, E1 component HTY60_12280 ENOG4105CKM Branched-chain carboxylic acid kinase HTY60_12285 ENOG4107RDP Dehydrogenase HTY60_12295 ENOG4108JUB Transcriptional regulator HTY60_12300 ENOG4106CCJ Protein of unknown function (DUF2627) HTY60_12305 ENOG4105CR4 methylisocitrate lyase HTY60_12310 ENOG4105DXD 2-methylcitrate dehydratase HTY60_12320 ENOG4105C1G acyl-Coa dehydrogenase HTY60_12335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HTY60_12340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HTY60_12365 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HTY60_12380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HTY60_12385 ENOG4107QQR Sporulation HTY60_12390 ENOG4105S1Z Stage IV sporulation protein B HTY60_12395 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HTY60_12400 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HTY60_12405 ENOG4105DX0 Hemolysin A HTY60_12410 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HTY60_12415 ENOG4105CTB Polyprenyl synthetase HTY60_12420 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HTY60_12425 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HTY60_12430 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HTY60_12435 ENOG4105M7K Involved in the transcription termination process (By similarity) HTY60_12440 ENOG4108ZSR alkaline shock protein HTY60_12445 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HTY60_12465 ENOG410644B Stage III sporulation protein af HTY60_12475 ENOG4105KQ4 Stage iii sporulation protein ad HTY60_12480 ENOG4108CQH stage III sporulation protein AC HTY60_12485 ENOG4105KR5 Stage iii sporulation protein HTY60_12490 ENOG4105CD2 stage iii sporulation protein aa HTY60_12500 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HTY60_12505 ENOG4105DC7 peptidase M24 HTY60_12515 ENOG4105CBJ Metal-dependent enzyme HTY60_12535 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HTY60_12540 ENOG4105WZW rhodanese family HTY60_12545 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HTY60_12555 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HTY60_12560 ENOG4105C0D helicase HTY60_12575 ENOG4108IMY Transcriptional regulator HTY60_12585 ENOG4105VFR signal peptidase HTY60_12645 ENOG4105C37 (CBS) domain HTY60_12670 ENOG4105C5X domain protein HTY60_12715 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HTY60_12730 ENOG41068DG YceG-like family HTY60_12735 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HTY60_12740 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HTY60_12745 ENOG4105E2Z phosphate ABC transporter (Permease HTY60_12750 ENOG4105C8U phosphate abc transporter HTY60_12755 ENOG4105CVA phosphate HTY60_12760 ENOG4107RF6 penicillin-binding protein HTY60_12770 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HTY60_12775 ENOG4105SXS Protein of unknown function (DUF456) HTY60_12790 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HTY60_12795 ENOG41063Y9 HTY60_12800 ENOG4108U5J '-nucleotidase HTY60_12805 ENOG4105N80 Ferric uptake regulator, Fur family HTY60_12810 ENOG4108JYZ YitT family HTY60_12815 ENOG41069ZM Protein of unknown function (DUF2624) HTY60_12820 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HTY60_12835 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HTY60_12840 ENOG4105EGD dinuclear metal center protein, YbgI family HTY60_12855 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_12860 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HTY60_12865 ENOG4108UPT UPF0178 protein HTY60_12870 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HTY60_12880 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HTY60_12885 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HTY60_12890 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HTY60_12900 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HTY60_12905 ENOG4105KG3 cytidine deaminase HTY60_12910 ENOG4107YR5 Diacylglycerol kinase HTY60_12915 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HTY60_12925 ENOG4105C9A Phoh family HTY60_12930 ENOG4105EI1 sporulation protein yqfd HTY60_12935 ENOG41068P3 sporulation protein YqfC HTY60_12945 ENOG4105DI5 UPF0365 protein HTY60_12950 ENOG4105F7J membrane-bound serine protease HTY60_12955 ENOG4105KTH gatB Yqey HTY60_12970 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HTY60_12975 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HTY60_12980 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HTY60_12985 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HTY60_12990 ENOG4105CFG Acts as a chaperone (By similarity) HTY60_12995 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HTY60_13000 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HTY60_13005 ENOG4105CSA Coproporphyrinogen iii oxidase HTY60_13010 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HTY60_13020 ENOG4108ZRV stage ii sporulation protein p HTY60_13025 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HTY60_13030 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HTY60_13035 ENOG4105TQK DNA polymerase iii, delta' subunit HTY60_13050 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HTY60_13055 ENOG4108UK2 deaminase HTY60_13060 ENOG4105KQC Competence protein HTY60_13070 ENOG4108D32 Methyltransferase HTY60_13080 ENOG4108WF2 Metal Dependent Phosphohydrolase HTY60_13085 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HTY60_13090 ENOG410812S Rna-binding protein HTY60_13095 ENOG4105E2X shikimate dehydrogenase HTY60_13100 ENOG4105CQW ribosome biogenesis GTPase YqeH HTY60_13105 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HTY60_13125 ENOG41080BT SNARE associated Golgi HTY60_13140 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_13160 ENOG4105CHR reductase HTY60_13175 ENOG4105DDQ anthranilate synthase HTY60_13200 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HTY60_13215 ENOG4105D29 Helix-turn-helix type 11 domain protein HTY60_13220 ENOG4108V4B ThiJ pfpI HTY60_13275 ENOG4105KVH Transcriptional regulator HTY60_13315 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HTY60_13320 ENOG4108J8C transporter major facilitator family protein HTY60_13330 ENOG4108U7W acetyltransferase HTY60_13345 ENOG4108HCJ Hydrolase HTY60_13360 ENOG4105DG6 mannose-6-phosphate isomerase HTY60_13365 ENOG4105DM4 PTS System HTY60_13380 ENOG4108Z66 YbaK ebsC protein HTY60_13385 ENOG4107RSM transcriptional regulator HTY60_13390 ENOG4105D94 Major Facilitator Superfamily HTY60_13395 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HTY60_13400 ENOG41082JN Transcriptional regulator HTY60_13420 ENOG4105TMB Formate nitrite transporter HTY60_13425 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HTY60_13430 ENOG4108JB9 formate dehydrogenase HTY60_13445 ENOG4105C28 cystathionine HTY60_13475 ENOG4107XRG penicillin-binding protein HTY60_13480 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HTY60_13490 ENOG4105CFP Peptidase U32 HTY60_13495 ENOG4105XYU peptidase (U32 family) HTY60_13505 ENOG4105HHA aminodeoxychorismate lyase HTY60_13515 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HTY60_13520 ENOG4105VBH UPF0297 protein HTY60_13525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HTY60_13530 ENOG4105C02 permease HTY60_13535 ENOG4105CDA abc transporter atp-binding protein HTY60_13540 ENOG4105CT1 (ABC) transporter HTY60_13545 ENOG4105EAD ABC transporter HTY60_13550 ENOG4105DRP amino acid AbC transporter HTY60_13560 ENOG41060CR HTY60_13570 ENOG4105C7H Helicase, RecD TraA family HTY60_13580 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HTY60_13585 ENOG4105C3J Cysteine desulfurase HTY60_13595 ENOG4105D1H recombination factor protein RarA HTY60_13600 ENOG4105CUZ uba thif-type nad fad binding protein HTY60_13610 ENOG4105C9M aspartyl-trna synthetase HTY60_13615 ENOG4105CUT histidyl-tRNA synthetase HTY60_13625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HTY60_13630 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HTY60_13635 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HTY60_13645 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HTY60_13650 ENOG41067VP Protein of unknown function (DUF1049) HTY60_13655 ENOG4105NCW Trka-c domain protein HTY60_13660 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HTY60_13670 ENOG4105CKP Polysaccharide Biosynthesis Protein HTY60_13675 ENOG4108QG2 Membrane HTY60_13680 ENOG4105NAP HTY60_13685 ENOG4105VIE preprotein translocase, subunit YajC HTY60_13690 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HTY60_13695 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HTY60_13700 ENOG41061AI Protein of unknown function (DUF2905) HTY60_13705 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HTY60_13710 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HTY60_13725 ENOG4106678 morphogenetic protein associated with SpoVID HTY60_13730 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HTY60_13735 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HTY60_13740 ENOG4108IYU L-aspartate oxidase HTY60_13755 ENOG4105CQC Prephenate dehydratase HTY60_13765 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HTY60_13775 ENOG4105K46 50S ribosomal protein l27 HTY60_13780 ENOG4105X36 (ribosomal) protein HTY60_13785 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HTY60_13800 ENOG4107QMS site-determining protein HTY60_13805 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HTY60_13810 ENOG4105YHC Rod shape-determining protein MreD HTY60_13820 ENOG4105DFF Rod shape-determining protein mreb HTY60_13825 ENOG4105W5Q DNA repair protein (RadC HTY60_13830 ENOG4108Z03 MAF-like protein HTY60_13840 ENOG4106A3R peptidase HTY60_13845 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HTY60_13850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HTY60_13860 ENOG4106AR7 Spore coat protein HTY60_13865 ENOG41068KH stage VI sporulation protein D HTY60_13870 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HTY60_13875 ENOG4105D52 delta-aminolevulinic acid dehydratase HTY60_13885 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HTY60_13895 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HTY60_13905 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HTY60_13910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HTY60_13915 ENOG4108IUQ atp-dependent protease HTY60_13920 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HTY60_13925 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HTY60_13935 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HTY60_13940 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HTY60_13945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HTY60_13955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HTY60_13960 ENOG4108ZP8 Acetolactate synthase small subunit HTY60_13965 ENOG4105C7K acetolactate synthase HTY60_13990 ENOG4105M59 Phosphodiesterase, mj0936 family HTY60_13995 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HTY60_14000 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HTY60_14005 ENOG4108XJQ germination protein HTY60_14010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HTY60_14015 ENOG41067TZ transcriptional regulator, MarR family HTY60_14020 ENOG4105PFC Transcriptional regulator HTY60_14030 ENOG4105E33 succinate dehydrogenase HTY60_14040 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HTY60_14050 ENOG4105CFH Aspartokinase HTY60_14055 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HTY60_14060 ENOG4105K63 Thioredoxin HTY60_14065 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HTY60_14070 ENOG4105C10 Electron transfer flavoprotein HTY60_14075 ENOG4105BZJ Electron transfer flavoprotein HTY60_14080 ENOG41060WC Enoyl-CoA hydratase HTY60_14085 ENOG4107Z3H Transcriptional regulator, TetR family HTY60_14090 ENOG4105CEY Amp-dependent synthetase and ligase HTY60_14095 ENOG4108YV3 Protein of unknown function (DUF2711) HTY60_14105 ENOG4105C98 muts2 protein HTY60_14110 ENOG4105DCG PHP domain protein HTY60_14125 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HTY60_14130 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HTY60_14135 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HTY60_14140 ENOG4108RWN rrna methyltransferase HTY60_14145 ENOG41067MF small acid-soluble spore protein HTY60_14155 ENOG4105CQB FAD linked oxidase domain protein HTY60_14160 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HTY60_14170 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HTY60_14175 ENOG4105DRS transport system, permease HTY60_14190 ENOG4108MDK Dehydrogenase HTY60_14200 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HTY60_14205 ENOG4105EF1 ribulokinase HTY60_14215 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HTY60_14220 ENOG4105CN9 Peptidase m42 family protein HTY60_14230 ENOG410696E Membrane HTY60_14235 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HTY60_14240 ENOG4105VJV 50s ribosomal protein L35 HTY60_14245 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HTY60_14250 ENOG41067MG lrgb family HTY60_14260 ENOG4105DY9 regulatoR HTY60_14265 ENOG4108HRK Histidine kinase HTY60_14275 ENOG4105C22 threonyL-tRNA synthetase HTY60_14280 ENOG4108TDW sporulation protein YtxC HTY60_14305 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HTY60_14310 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HTY60_14315 ENOG4105KVH Transcriptional regulator HTY60_14320 ENOG4105F27 Major Facilitator HTY60_14325 ENOG4105CV8 reductase HTY60_14330 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HTY60_14340 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HTY60_14345 ENOG4105C2M dna polymerase I HTY60_14350 ENOG4105BZU Histidine kinase HTY60_14355 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HTY60_14365 ENOG4108HMX isocitrate dehydrogenase (NADP) HTY60_14370 ENOG4105BZN citrate synthase HTY60_14380 ENOG4108REF Sporulation integral membrane protein ytvi HTY60_14385 ENOG4105FS0 cytoplasmic membrane protein HTY60_14390 ENOG4105CA9 Pyruvate kinase HTY60_14395 ENOG4105CTQ phosphohexokinase HTY60_14400 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HTY60_14405 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HTY60_14410 ENOG4105C6K Malic enzyme HTY60_14415 ENOG4105C0B DNA polymerase III (alpha subunit) HTY60_14420 ENOG4105VV2 HTY60_14430 ENOG4106EVM HTY60_14435 ENOG4105SFS phosphoesterase RecJ domain protein HTY60_14450 ENOG4105E8R UPF0173 metal-dependent hydrolase HTY60_14460 ENOG4105CH7 arginosuccinase HTY60_14465 ENOG4105CDH Citrulline--aspartate ligase HTY60_14470 ENOG4105EPU Molybdenum cofactor synthesis domain protein HTY60_14475 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HTY60_14485 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HTY60_14490 ENOG4105KBJ sporulation protein ytfj HTY60_14500 ENOG4105VK3 rdd domain containing protein HTY60_14505 ENOG4105D07 Signal peptide peptidase, SppA HTY60_14510 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HTY60_14515 ENOG4105EFZ amidohydrolase HTY60_14520 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HTY60_14530 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HTY60_14555 ENOG4105U5Y Transcriptional regulator HTY60_14565 ENOG4105BZU Histidine kinase HTY60_14570 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HTY60_14575 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HTY60_14605 ENOG4108NGU Transcriptional regulator HTY60_14610 ENOG4108UMN azlc family HTY60_14620 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HTY60_14630 ENOG4105F1V Acetoin utilization protein HTY60_14635 ENOG4105W87 Cbs domain HTY60_14640 ENOG4105DGU Histone deacetylase HTY60_14645 ENOG4105ER2 Ompa motb domain protein HTY60_14650 ENOG4107R0U MotA TolQ exbB proton channel HTY60_14655 ENOG4105ETE Transcriptional regulator (LacI family HTY60_14660 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HTY60_14680 ENOG4105DFU Cell wall formation (By similarity) HTY60_14690 ENOG4108VDD TRNA binding domain protein HTY60_14705 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HTY60_14725 ENOG4105C8F Beta-lactamase domain protein HTY60_14730 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HTY60_14740 ENOG4108V15 phosphotransferase enzyme family HTY60_14755 ENOG4107F58 2'-5' rna ligase HTY60_14760 ENOG4105C6T cysteine synthase HTY60_14765 ENOG4107QSE Dipeptidase HTY60_14770 ENOG4105C7N Xanthine uracil vitamin C permease HTY60_14785 ENOG4105YW5 deoR family transcriptional regulator HTY60_14800 ENOG4105CBX hi0933 family HTY60_14805 ENOG4105C94 Transporter HTY60_14845 ENOG41085GJ domain protein HTY60_14850 ENOG4105C8T Leucyl-tRNA synthetase HTY60_14860 ENOG4105BZU Histidine kinase HTY60_14865 ENOG410605W Major Facilitator HTY60_14880 ENOG4105C19 ABC transporter HTY60_14885 ENOG4105EWM Histidine kinase HTY60_14895 ENOG4107R34 abc transporter permease protein HTY60_14900 ENOG4105C19 ABC transporter HTY60_14920 ENOG4105DVE abc transporter atp-binding protein HTY60_14940 ENOG4105N5T Radical SAM Protein HTY60_14960 ENOG4105E8V Alpha Beta Hydrolase Fold protein HTY60_14965 ENOG4108Z0R Transferase HTY60_14970 ENOG4105C85 amino acid HTY60_14975 ENOG4105CAQ asparagine synthetase HTY60_14980 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HTY60_14985 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HTY60_15000 ENOG4105D2X ABC transporter substrate-binding protein HTY60_15010 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HTY60_15025 ENOG4108RMU ferritin dps family protein HTY60_15040 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HTY60_15045 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HTY60_15050 ENOG4108V2W Carbonate dehydratase HTY60_15055 ENOG4105NRA 50s ribosomal protein l31 type b HTY60_15075 ENOG4105DTQ mandelate racemase muconate lactonizing HTY60_15080 ENOG4105CEY Amp-dependent synthetase and ligase HTY60_15085 ENOG4108IPT Naphthoate synthase HTY60_15090 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HTY60_15095 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HTY60_15100 ENOG4105E4F Isochorismate synthase HTY60_15235 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HTY60_15240 ENOG4105DZ6 Band 7 protein HTY60_15250 ENOG4106DF1 HTY60_15255 ENOG4108VNY MOSC domain protein HTY60_15260 ENOG4108JB8 alcohol dehydrogenase HTY60_15270 ENOG4105TRT Transcriptional regulator HTY60_15285 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HTY60_15290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HTY60_15355 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HTY60_15375 ENOG41068G1 HTY60_15395 ENOG4108FKH Transglycosylase SLT domain HTY60_15535 ENOG4105VTR Integrase HTY60_15545 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HTY60_15555 ENOG4105EE0 oxidoreductase HTY60_15560 ENOG4108Z0Z intracellular protease Pfpi family HTY60_15570 ENOG4105C8Q Methyl-accepting chemotaxis HTY60_15575 ENOG4105C8Q Methyl-accepting chemotaxis HTY60_15580 ENOG4105C8Q Methyl-accepting chemotaxis HTY60_15595 ENOG4105EA8 2-Nitropropane dioxygenase HTY60_15610 ENOG4105C37 (CBS) domain HTY60_15625 ENOG4107PBV potassium channel HTY60_15630 ENOG4107PBV potassium channel HTY60_15645 ENOG4107QYV phosphohexose isomerase HTY60_15655 ENOG4107QW4 alcohol dehydrogenase HTY60_15660 ENOG4105WG9 Conserved Protein HTY60_15670 ENOG4105CHM Aminotransferase HTY60_15675 ENOG4108ZB6 transcriptional regulator AsnC family HTY60_15680 ENOG4108MUZ hydrolase HTY60_15690 ENOG4105C87 Aminotransferase class I and II HTY60_15695 ENOG4108HGU Histidine kinase HTY60_15700 ENOG4105Y38 Kinase-associated protein B HTY60_15715 ENOG4105BZ4 penicillin-binding protein HTY60_15720 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HTY60_15735 ENOG4108MRH transcriptional regulatory protein HTY60_15740 ENOG4105DIH basic membrane HTY60_15745 ENOG4108JQ9 ABC transporter HTY60_15750 ENOG4105UIB (ABC) transporter HTY60_15765 ENOG4105D65 subunit l HTY60_15770 ENOG4105HC0 Na H antiporter HTY60_15775 ENOG4108ZE9 Monovalent cation H antiporter subunit C HTY60_15780 ENOG4108JPZ Monovalent cation H antiporter subunit D HTY60_15785 ENOG4105SC1 monovalent cation H antiporter subunit E HTY60_15795 ENOG4105KJM monovalent cation h antiporter subunit g HTY60_15800 ENOG4105KA0 thioesterase Superfamily protein HTY60_15810 ENOG4105BZU Histidine kinase HTY60_15835 ENOG4105D58 Diguanylate phosphodiesterase HTY60_15840 ENOG4105DAP Nicotinate phosphoribosyltransferase HTY60_15865 ENOG4105C02 permease HTY60_15880 ENOG410904N short-chain dehydrogenase reductase HTY60_15915 ENOG4108K8K Transcriptional regulator HTY60_15920 ENOG4105DCF alanine dehydrogenase HTY60_15930 ENOG4105WQT MbtH domain protein HTY60_15940 ENOG4105WQI isochorismatase HTY60_15945 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HTY60_15950 ENOG4105E4F Isochorismate synthase HTY60_15955 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HTY60_15960 ENOG4105NIV Esterase HTY60_15980 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HTY60_16005 ENOG4105CEP NADH dehydrogenase HTY60_16020 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HTY60_16035 ENOG4105CJ1 ABC, transporter HTY60_16060 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HTY60_16065 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HTY60_16070 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HTY60_16080 ENOG4105ZKE UPF0349 protein HTY60_16095 ENOG41083MR nifu domain-containing protein HTY60_16105 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HTY60_16110 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HTY60_16115 ENOG4105D6E homoserine dehydrogenase HTY60_16125 ENOG4108W5N phosphatidylglycerophosphatase a HTY60_16130 ENOG4105D4U had-superfamily hydrolase, subfamily iia HTY60_16140 ENOG4105MMD transcriptional regulator HTY60_16145 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HTY60_16150 ENOG4105FAA peptidase M23 HTY60_16155 ENOG4108YTE sporulation protein YunB HTY60_16160 ENOG4107R8B 5'-nucleotidase HTY60_16170 ENOG4105I3N Conserved Protein HTY60_16180 ENOG4105CD3 dihydroorotase HTY60_16185 ENOG4105G9B Transcriptional regulator HTY60_16195 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HTY60_16210 ENOG4105C5R Aminotransferase HTY60_16220 ENOG4108K8S endonuclease I HTY60_16225 ENOG4108IJ9 (ABC) transporter HTY60_16230 ENOG4105FDP GntR family transcriptional regulator HTY60_16235 ENOG4108KPW sugar kinase HTY60_16240 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HTY60_16245 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HTY60_16250 ENOG4105XN3 extracellular solute-binding protein family 1 HTY60_16255 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HTY60_16260 ENOG4108Z6Z Transcriptional regulator HTY60_16285 ENOG4105PKS Excinuclease abc c subunit domain protein HTY60_16290 ENOG4107VFR oxidoreductase HTY60_16305 ENOG41083Q9 chitosanase HTY60_16325 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HTY60_16345 ENOG41068G1 HTY60_16355 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HTY60_16365 ENOG4108FKH Transglycosylase SLT domain HTY60_16465 ENOG4105C2M dna polymerase I HTY60_16515 ENOG4108IMY Transcriptional regulator HTY60_16530 ENOG4105DIW FeS assembly protein SUFB HTY60_16535 ENOG4108UNV SUF system FeS assembly protein, NifU family HTY60_16540 ENOG4105C9B Cysteine desulfurase HTY60_16545 ENOG4105JRK feS assembly protein SufD HTY60_16550 ENOG4105C3K feS assembly ATPase SufC HTY60_16565 ENOG4105D01 (LipO)protein HTY60_16570 ENOG4108UMI ABC transporter, permease HTY60_16575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HTY60_16600 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HTY60_16605 ENOG41080E8 Transcriptional regulator, Spx MgsR family HTY60_16610 ENOG4105C1G acyl-Coa dehydrogenase HTY60_16615 ENOG4105CHU acetyl-coa acetyltransferase HTY60_16645 ENOG41067TZ transcriptional regulator, MarR family HTY60_16650 ENOG4105C0R drug resistance transporter emrb qaca subfamily HTY60_16675 ENOG4105E0A ABC, transporter HTY60_16690 ENOG4105E1F short-chain dehydrogenase reductase HTY60_16695 ENOG4105HUF DNA protection during starvation protein HTY60_16700 ENOG4105C0H protease HTY60_16710 ENOG4105F3H Histidine kinase HTY60_16720 ENOG41067SE Tetr family transcriptional regulator HTY60_16725 ENOG4105C9Q fumarate hydratase class II HTY60_16750 ENOG4105WH1 Two component transcriptional regulator luxr family HTY60_16755 ENOG4105ENE Histidine kinase HTY60_16770 ENOG41087YS Phage shock protein A HTY60_16785 ENOG4108WBT adenosyltransferase HTY60_16790 ENOG4105E0A ABC, transporter HTY60_16795 ENOG4105EHG Permease protein HTY60_16800 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HTY60_16805 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HTY60_16810 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HTY60_16820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HTY60_16830 ENOG4106DF4 Sigma-70, region 4 HTY60_16840 ENOG4105F0F Oxalate decarboxylase HTY60_16850 ENOG4105E0A ABC, transporter HTY60_16855 ENOG4105EHG Permease protein HTY60_16860 ENOG4105DQ5 transport system permease protein HTY60_16870 ENOG4105JQZ Methyltransferase HTY60_16875 ENOG4105D5Q Arginine ornithine antiporter HTY60_16885 ENOG4107K5X Membrane-bound metal-dependent hydrolase HTY60_16895 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HTY60_16900 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HTY60_16905 ENOG4105E0C molybdate abc transporter HTY60_16910 ENOG4105WH1 Two component transcriptional regulator luxr family HTY60_16920 ENOG4105CJ1 ABC, transporter HTY60_16930 ENOG4108KYE ABC-2 type transporter HTY60_16945 ENOG4105EEQ Na H antiporter HTY60_16950 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HTY60_16955 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HTY60_16965 ENOG4105EN6 Membrane HTY60_16980 ENOG4107ZQN disulfide bond HTY60_16985 ENOG4105C59 p-type ATPase HTY60_16990 ENOG4105C59 p-type ATPase HTY60_16995 ENOG410681U heavy metal transport detoxification protein HTY60_17000 ENOG4105VPX protein, conserved in bacteria HTY60_17005 ENOG4105D9R oxidoreductase HTY60_17010 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HTY60_17025 ENOG4105DEN Luciferase family HTY60_17030 ENOG4105CDA abc transporter atp-binding protein HTY60_17055 ENOG4108XSB acetyltransferase, (GNAT) family HTY60_17060 ENOG4108KSA LysR family transcriptional regulator HTY60_17065 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HTY60_17070 ENOG41067XF inhibitor HTY60_17080 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HTY60_17085 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HTY60_17095 ENOG4105XZU Preprotein translocase, subunit SecG HTY60_17115 ENOG4105KVH Transcriptional regulator HTY60_17140 ENOG4105DA5 (ABC) transporter HTY60_17145 ENOG4105R40 Glycine betaine carnitine choline HTY60_17150 ENOG4108HQR Glycine betaine HTY60_17155 ENOG4105E90 ABC transporter HTY60_17160 ENOG4108IJ8 ABC transporter HTY60_17165 ENOG4107HG4 Transcriptional regulator HTY60_17170 ENOG4105R40 Glycine betaine carnitine choline HTY60_17175 ENOG4108HQR Glycine betaine HTY60_17180 ENOG4105E90 ABC transporter HTY60_17185 ENOG4108IJ8 ABC transporter HTY60_17190 ENOG4107HG4 Transcriptional regulator HTY60_17195 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HTY60_17205 ENOG4105T65 Membrane-associated protein HTY60_17210 ENOG4108W0I acetyltransferase HTY60_17225 ENOG4105FJR Lmbe family HTY60_17245 ENOG4108IAJ Nad-dependent epimerase dehydratase HTY60_17250 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HTY60_17255 ENOG4107QQG Dehydrogenase HTY60_17260 ENOG4105IIU Aminopeptidase HTY60_17265 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HTY60_17270 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HTY60_17275 ENOG4105CP7 Triose-phosphate isomerase HTY60_17280 ENOG4105BZA Phosphoglycerate kinase HTY60_17285 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HTY60_17300 ENOG4105CMD Transcriptional regulator, GntR family HTY60_17305 ENOG4105DEN Luciferase family HTY60_17315 ENOG4107RT3 EamA-like transporter family HTY60_17330 ENOG4106KNT transcriptional regulator HTY60_17335 ENOG4105CMG Carbohydrate kinase HTY60_17340 ENOG4105C6Z Gluconate HTY60_17350 ENOG4107QR9 Iron-sulfur cluster binding protein HTY60_17355 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HTY60_17360 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HTY60_17365 ENOG4105JXH GntR family transcriptional regulator HTY60_17370 ENOG4105DAA L-lactate HTY60_17375 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HTY60_17395 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HTY60_17400 ENOG4105D3Q Sugar transferase HTY60_17410 ENOG4105K64 Glycosyl transferase, family 2 HTY60_17420 ENOG4107QRS glycosyltransferase group 2 family protein HTY60_17425 ENOG41068W6 Capsular polysaccharide biosynthesis protein HTY60_17430 ENOG4108KMV Glycosyl transferase (Group 1 HTY60_17435 ENOG4105K64 Glycosyl transferase, family 2 HTY60_17440 ENOG4108PQP glycosyl transferase group 1 HTY60_17450 ENOG4108QV3 biosynthesis protein HTY60_17455 ENOG4105HTX biosynthesis protein HTY60_17465 ENOG4105EBR Carboxylesterase HTY60_17475 ENOG4105NAE bifunctional deaminase-reductase domain protein HTY60_17480 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HTY60_17495 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HTY60_17500 ENOG4105PY6 Phenolic acid decarboxylase HTY60_17505 ENOG4105NI3 Protein of unknown function (DUF3237) HTY60_17540 ENOG4108HKT sucrose-6-phosphate hydrolase HTY60_17545 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HTY60_17550 ENOG4105ETE Transcriptional regulator (LacI family HTY60_17555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HTY60_17560 ENOG4108KAM Transcriptional regulator HTY60_17565 ENOG4105C7F AcnD-accessory protein PrpF HTY60_17580 ENOG4108URH decarboxylase HTY60_17585 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HTY60_17590 ENOG4105CHH sulfate transporter HTY60_17595 ENOG4108V2W Carbonate dehydratase HTY60_17600 ENOG4105C5I Dehydrogenase HTY60_17605 ENOG4105GGE ribonuclease HTY60_17610 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HTY60_17615 ENOG4105KRI phosphocarrier protein (HPr HTY60_17620 ENOG4105CIE May be required for sporulation (By similarity) HTY60_17625 ENOG4105CHW UPF0052 protein HTY60_17630 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HTY60_17635 ENOG4108Z4K mutator MutT protein HTY60_17640 ENOG4105C3M thioredoxin reductase HTY60_17655 ENOG4105BZU Histidine kinase HTY60_17660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HTY60_17665 ENOG4105BZ1 (ABC) transporter HTY60_17670 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HTY60_17675 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HTY60_17680 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HTY60_17685 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HTY60_17690 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HTY60_17695 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HTY60_17700 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HTY60_17705 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HTY60_17715 ENOG4108S4C acetyltransferase HTY60_17720 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HTY60_17730 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HTY60_17735 ENOG4105CE4 GlcNAc 6-P deacetylase HTY60_17740 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HTY60_17750 ENOG4105J7D transcriptional regulator HTY60_17755 ENOG41088CQ domain protein HTY60_17760 ENOG41086DT Membrane protein of unknown function HTY60_17765 ENOG41067S9 phage shock protein C, PspC HTY60_17770 ENOG4108PY7 HTY60_17785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HTY60_17790 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HTY60_17805 ENOG4105MKU Transcriptional regulator HTY60_17835 ENOG4105CN1 protease HTY60_17840 ENOG4108M26 parallel beta-helix repeat protein HTY60_17845 ENOG4105CRP Part of the ABC transporter FtsEX involved in HTY60_17850 ENOG4105CAK Cell division ATP-binding protein ftsE HTY60_17870 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HTY60_17875 ENOG4105MS2 ribosomal subunit Interface protein HTY60_17890 ENOG4105MQ3 flagellar protein FliS HTY60_17895 ENOG4107RT6 flagellar hook-associated HTY60_17900 ENOG4105I03 Flagellin HTY60_17905 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HTY60_17910 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HTY60_17920 ENOG4105DTJ flagellar hook-associated protein HTY60_17940 ENOG4105RU3 HTY60_17945 ENOG41081UC Inherit from COG: Competence protein HTY60_17965 ENOG4105WH1 Two component transcriptional regulator luxr family HTY60_17970 ENOG4105BZU Histidine kinase HTY60_17975 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HTY60_17980 ENOG4108KGH TRANSCRIPTIONal HTY60_17985 ENOG4105ESV Glycosyl transferase, family 4 HTY60_17990 ENOG4107EF8 Glycosyl transferase (Group 1 HTY60_18005 ENOG4105QZI O-Antigen Polymerase HTY60_18010 ENOG4105C6Y Udp-glucose 6-dehydrogenase HTY60_18015 ENOG4107RA4 Glycosyl transferase (Group 1 HTY60_18020 ENOG4105PSV Polysaccharide Biosynthesis Protein HTY60_18025 ENOG4105D3Q Sugar transferase HTY60_18030 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HTY60_18035 ENOG4105JFG SpoIID LytB domain protein HTY60_18045 ENOG4108KGH TRANSCRIPTIONal HTY60_18050 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HTY60_18055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HTY60_18060 ENOG4105EY8 ABC transporter HTY60_18070 ENOG4107SJB teichoic acid biosynthesis HTY60_18075 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HTY60_18080 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HTY60_18090 ENOG4107RZX Teichoic acid biosynthesis protein HTY60_18100 ENOG4105DG6 mannose-6-phosphate isomerase HTY60_18115 ENOG4108NHD germination protein HTY60_18120 ENOG4108NHD germination protein HTY60_18125 ENOG4108SHN Glycosyl transferase, family 2 HTY60_18130 ENOG4105C54 Major Facilitator superfamily HTY60_18135 ENOG4108KGH TRANSCRIPTIONal HTY60_18140 ENOG4105J7I hydrolase HTY60_18145 ENOG4106UBQ HTY60_18150 ENOG4105K4H Nlp p60 protein HTY60_18160 ENOG4105PNM synthesis protein HTY60_18170 ENOG4105N98 Capsule biosynthesis protein capB HTY60_18190 ENOG4105ETE Transcriptional regulator (LacI family HTY60_18195 ENOG4108RVA ribokinase HTY60_18200 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HTY60_18205 ENOG4105C2J ABC transporter HTY60_18210 ENOG4105CNN ABC, transporter HTY60_18215 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HTY60_18225 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HTY60_18230 ENOG4107FQX Alpha-acetolactate decarboxylase HTY60_18240 ENOG4107RSM transcriptional regulator HTY60_18255 ENOG4106UIA HTY60_18270 ENOG4107XC4 flavin reductase domain protein, FMN-binding HTY60_18280 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HTY60_18290 ENOG4105CAH Chromate HTY60_18295 ENOG4105FGV Chromate HTY60_18345 ENOG4108XI2 Domain of unknown function (DUF1963) HTY60_18350 ENOG4105C6Y Udp-glucose 6-dehydrogenase HTY60_18355 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HTY60_18360 ENOG4107YJ4 chain length determinant protein HTY60_18365 ENOG4105HTX biosynthesis protein HTY60_18375 ENOG4105KBK Zinc finger, swim domain protein HTY60_18380 ENOG4105C0D helicase HTY60_18385 ENOG410667J hydrolase HTY60_18390 ENOG4105E98 transcriptional regulator DeoR family HTY60_18395 ENOG4105Z8H single-stranded DNA-binding protein HTY60_18410 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HTY60_18415 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HTY60_18425 ENOG4105CGA flagellar basal-body rod protein FlgG HTY60_18435 ENOG4105DFF Rod shape-determining protein mreb HTY60_18440 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HTY60_18445 ENOG4107MII Sugar-specific transcriptional regulator TrmB HTY60_18455 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HTY60_18460 ENOG41080V3 Major Facilitator superfamily HTY60_18465 ENOG4105D3W isochorismatase HTY60_18470 ENOG4105BZU Histidine kinase HTY60_18480 ENOG4105CNI cell division protein FtsW HTY60_18485 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HTY60_18495 ENOG4105FRN stage II sporulation protein HTY60_18500 ENOG4107TCE N-acetyltransferase HTY60_18515 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HTY60_18525 ENOG4106BRK HTY60_18530 ENOG4108RYK Nad-dependent epimerase dehydratase HTY60_18535 ENOG4108Z40 Transcriptional regulator HTY60_18540 ENOG4105CQM Urea amidohydrolase subunit alpha HTY60_18545 ENOG4105KI2 Urea amidohydrolase subunit beta HTY60_18550 ENOG4108YZ9 Urea amidohydrolase subunit gamma HTY60_18570 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HTY60_18575 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HTY60_18585 ENOG4108TF4 von Willebrand factor, type A HTY60_18600 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HTY60_18610 ENOG4106778 Protein of unknown function (DUF1146) HTY60_18620 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HTY60_18625 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HTY60_18630 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HTY60_18635 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HTY60_18640 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HTY60_18655 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HTY60_18665 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HTY60_18670 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HTY60_18675 ENOG4108UIC UPF0340 protein HTY60_18680 ENOG4108YZG isomerase HTY60_18685 ENOG4107WAU Protein tyrosine phosphatase HTY60_18690 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HTY60_18695 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HTY60_18705 ENOG4108ZXQ stage ii sporulation protein r HTY60_18720 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HTY60_18725 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HTY60_18730 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HTY60_18740 ENOG4107TT2 Auxin Efflux Carrier HTY60_18745 ENOG4105C6K Malic enzyme HTY60_18750 ENOG4107104 thymidine kinase HTY60_18760 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HTY60_18765 ENOG4105CBT Fructose-1,6-bisphosphatase HTY60_18770 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HTY60_18780 ENOG4105D2N Aldolase HTY60_18785 ENOG410812K response regulator receiver protein HTY60_18795 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HTY60_18805 ENOG4105DF6 Fe-S oxidoreductase HTY60_18815 ENOG4105E5J UV damage endonuclease HTY60_18825 ENOG4105BZ1 (ABC) transporter HTY60_18830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HTY60_18840 ENOG4105R3A Nitrate reductase HTY60_18845 ENOG4108IUE nitrate reductase beta subunit HTY60_18865 ENOG4107V6Q Cyclic nucleotide-binding domain HTY60_18875 ENOG4105C75 arginyL-tRNA synthetase HTY60_18880 ENOG410684U Domain of unknown function (DUF1934) HTY60_18895 ENOG4107JM4 Tetratricopeptide repeat HTY60_18905 ENOG4105CYW agmatinase HTY60_18910 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HTY60_18915 ENOG4105BZ4 penicillin-binding protein HTY60_18925 ENOG4108XFG YwhD family HTY60_18930 ENOG4108Z4T Peptidase M50 HTY60_18935 ENOG41069HH 4-oxalocrotonate tautomerase HTY60_18940 ENOG41067TZ transcriptional regulator, MarR family HTY60_18945 ENOG4105CUB amino acid HTY60_18955 ENOG4105DCI Phosphohydrolase HTY60_18965 ENOG4108VCI transcription factor, rsfa family HTY60_18970 ENOG4105K7K Transcriptional regulator HTY60_18980 ENOG4105CJ1 ABC, transporter HTY60_18985 ENOG4108TU7 Inherit from COG: (ABC) transporter HTY60_19010 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HTY60_19015 ENOG4105DUM transcriptional regulator, lysR family HTY60_19020 ENOG4105HMI Membrane HTY60_19025 ENOG4108IJ2 phosphate acetyltransferase HTY60_19030 ENOG4107JTW chlorite dismutase HTY60_19050 ENOG4105CHM Aminotransferase HTY60_19060 ENOG4108M32 ATP-grasp domain HTY60_19080 ENOG4105FCW Major Facilitator superfamily HTY60_19085 ENOG4105C2C drug resistance transporter, Bcr CflA HTY60_19100 ENOG4105C26 Dehydrogenase HTY60_19105 ENOG4105D82 Glutamate dehydrogenase HTY60_19115 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HTY60_19120 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HTY60_19125 ENOG4105C1B dTDP-glucose 4-6-dehydratase HTY60_19130 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HTY60_19135 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HTY60_19140 ENOG4107TY6 Acylneuraminate cytidylyltransferase HTY60_19150 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HTY60_19155 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HTY60_19190 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HTY60_19195 ENOG4108RJ9 Glycosyl transferase, family 2 HTY60_19205 ENOG4105DWF phosphomethylpyrimidine kinase HTY60_19220 ENOG4105C5Y PTS System HTY60_19235 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HTY60_19240 ENOG4105DEN Luciferase family HTY60_19245 ENOG4105D29 Helix-turn-helix type 11 domain protein HTY60_19250 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HTY60_19265 ENOG4108DBC nitroreductase HTY60_19275 ENOG4105I4A GCN5-related N-acetyltransferase HTY60_19295 ENOG4105BZ9 Cytochrome C oxidase, subunit I HTY60_19300 ENOG4105E2S oxidase) subunit II HTY60_19305 ENOG4107BMA Transglycosylase associated protein HTY60_19315 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HTY60_19320 ENOG4105WH5 Teichoic acid glycosylation protein HTY60_19345 ENOG4107ZXU DSBA oxidoreductase HTY60_19350 ENOG4105DBE peroxidase HTY60_19355 ENOG410650H (LipO)protein HTY60_19360 ENOG4107SJW iron permease, FTR1 HTY60_19365 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HTY60_19370 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HTY60_19375 ENOG4105CMU LysR family (Transcriptional regulator HTY60_19380 ENOG4105VAW lrga family HTY60_19385 ENOG41067MG lrgb family HTY60_19395 ENOG4107TXC Transcriptional regulator HTY60_19405 ENOG4105DR4 Methyltransferase HTY60_19415 ENOG4105CK1 PTS System HTY60_19420 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HTY60_19425 ENOG4105X1N Glycosyl transferase family 8 HTY60_19435 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HTY60_19445 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HTY60_19450 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HTY60_19455 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HTY60_19460 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HTY60_19465 ENOG4105CM2 brancheD-chain amino acid aminotransferase HTY60_19470 ENOG4105F8D glycoside hydrolase family 4 HTY60_19475 ENOG4105VCP PTS System HTY60_19480 ENOG4105CK1 PTS System HTY60_19485 ENOG4105VZJ PTS System HTY60_19490 ENOG4105EMD TRANSCRIPTIONal HTY60_19500 ENOG4105DQ5 transport system permease protein HTY60_19505 ENOG4105EHG Permease protein HTY60_19515 ENOG41082YX Transcriptional regulator, arsr family HTY60_19520 ENOG4107R5R arsenical pump membrane protein HTY60_19525 ENOG4105VZJ PTS System HTY60_19530 ENOG4105VCP PTS System HTY60_19535 ENOG4105CK1 PTS System HTY60_19540 ENOG4105CS2 ec 3.2.1.21 HTY60_19545 ENOG4105EVU fructokinase HTY60_19550 ENOG4105DG6 mannose-6-phosphate isomerase HTY60_19560 ENOG4105CH6 catalase HTY60_19565 ENOG4107QHE Choloylglycine hydrolase HTY60_19570 ENOG4105ETS cytosine purines uracil thiamine allantoin HTY60_19580 ENOG4108JJ8 (ABC) transporter HTY60_19585 ENOG4108JJ9 ABC, transporter HTY60_19590 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HTY60_19595 ENOG4105C4M (Ubiquinol oxidase) subunit I HTY60_19600 ENOG4105D2K citrate carrier protein HTY60_19605 ENOG4107BJW polysaccharide deacetylase HTY60_19620 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HTY60_19630 ENOG4105CMR udp-glucose 4-epimerase HTY60_19635 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HTY60_19655 ENOG4105DHI Methyltransferase HTY60_19680 ENOG4105CH6 catalase HTY60_19695 ENOG4105CID antiterminator HTY60_19700 ENOG4105DEU major facilitator superfamily HTY60_19705 ENOG4105C1J atp-dependent rna helicase HTY60_19750 ENOG4108NR7 pectate lyase HTY60_19760 ENOG4107YZX Universal stress protein HTY60_19765 ENOG4105CS2 ec 3.2.1.21 HTY60_19770 ENOG4105C5Y PTS System HTY60_19785 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HTY60_19805 ENOG4106Z5D Glycoside Hydrolase Family 43 HTY60_19815 ENOG4105C84 Histidine ammonia-lyase HTY60_19820 ENOG4105CGP Urocanate hydratase HTY60_19825 ENOG4105CI2 imidazolone-5-propionate hydrolase HTY60_19830 ENOG4107W25 arginase agmatinase formiminoglutamase HTY60_19840 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HTY60_19845 ENOG4105D9N nucleoside HTY60_19850 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HTY60_19855 ENOG4107RHR regulatoR HTY60_19860 ENOG410667J hydrolase HTY60_19890 ENOG4108V5C ABC transporter HTY60_19925 ENOG4105WZ4 isomerase HTY60_19930 ENOG4105F0H myo-inositol catabolism protein HTY60_19935 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HTY60_19945 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HTY60_19955 ENOG4105EDK PfkB domain protein HTY60_19965 ENOG4105C26 Dehydrogenase HTY60_19975 ENOG4105CPC Aldo Keto reductase HTY60_19980 ENOG4107QNK )-transporter HTY60_19985 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HTY60_19990 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HTY60_19995 ENOG4108S01 response regulator HTY60_20000 ENOG4108ZGX Histidine kinase HTY60_20005 ENOG4105ECK Fatty Acid Desaturase HTY60_20010 ENOG4105ST3 Transcriptional regulator HTY60_20015 ENOG4105C26 Dehydrogenase HTY60_20020 ENOG4108ITS PQQ enzyme repeat HTY60_20030 ENOG4105WAB arsR family transcriptional regulator HTY60_20035 ENOG4105F27 Major Facilitator HTY60_20040 ENOG41085PJ rdd domain containing protein HTY60_20050 ENOG4105D3R alkyl hydroperoxide reductase HTY60_20055 ENOG4108JU3 Alkyl hydroperoxide reductase HTY60_20065 ENOG4105C85 amino acid HTY60_20115 ENOG41090VF Stage v sporulation protein ac HTY60_20120 ENOG4105CZ3 stage V sporulation protein ad HTY60_20135 ENOG4108QY0 Membrane HTY60_20160 ENOG4108XHQ (2Fe-2S)-binding domain protein HTY60_20180 ENOG4105XRQ Xanthine dehydrogenase accessory factor HTY60_20210 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HTY60_20230 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HTY60_20235 ENOG4105CPC Aldo Keto reductase HTY60_20240 ENOG4105WQG acetyltransferase HTY60_20250 ENOG41066UZ arginase EC 3.5.3.1 HTY60_20255 ENOG4108IQI permease HTY60_20260 ENOG4105C8Y Acetylornithine aminotransferase HTY60_20270 ENOG41082BM Transcriptional regulator, arsr family HTY60_20275 ENOG4108JUB Transcriptional regulator HTY60_20290 ENOG41062D9 Histidine kinase HTY60_20305 ENOG4105C0H protease HTY60_20310 ENOG4105Q2H domain protein HTY60_20325 ENOG4105BZU Histidine kinase HTY60_20330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HTY60_20355 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HTY60_20360 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HTY60_20365 ENOG4105CDU Replicative dna helicase HTY60_20395 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HTY60_20400 ENOG4105CPK Glycosyl transferase (Group 1 HTY60_20420 ENOG4105BZR domain protein HTY60_20425 ENOG4108XMW Membrane HTY60_20440 ENOG4105KVH Transcriptional regulator HTY60_20445 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HTY60_20450 ENOG4108UZ3 Transporter HTY60_20455 ENOG4105EDQ levansucrase EC 2.4.1.10 HTY60_20460 ENOG4108HKT sucrose-6-phosphate hydrolase HTY60_20485 ENOG4108TVJ Nitroreductase HTY60_20490 ENOG4105FS7 Transcriptional regulator HTY60_20500 ENOG4108U05 Transcriptional regulator HTY60_20505 ENOG41082BV acetyltransferase HTY60_20510 ENOG41085FC arsR family transcriptional regulator HTY60_20515 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HTY60_20535 ENOG4107FCW Abortive infection protein HTY60_20545 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HTY60_20555 ENOG4105CGK Exodeoxyribonuclease III HTY60_20560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HTY60_20570 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HTY60_20575 ENOG4108UUM single-stranded DNA-binding protein HTY60_20580 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HTY60_20585 ENOG4105C3G gtp-binding protein HTY60_20590 ENOG4108J2R molybdopterin oxidoreductase HTY60_20595 ENOG4105VDK protein, conserved in bacteria HTY60_20610 ENOG4108ZDA Sporulation protein YyaC HTY60_20615 ENOG4105FA0 parb-like partition protein HTY60_20620 ENOG4107QJE Chromosome Partitioning Protein HTY60_20635 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HTY60_20640 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HTY60_20655 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)