locus-tag class description EXD81_00005 ENOG4108VPT UPF0234 protein EXD81_00015 ENOG4105MA6 gCN5-related N-acetyltransferase EXD81_00020 ENOG4105MYW Pentapeptide repeat protein EXD81_00030 ENOG4105SF0 DinB family EXD81_00035 ENOG4106HBX Transcriptional Regulator AraC Family EXD81_00040 ENOG4105UQX Mate efflux family protein EXD81_00070 ENOG4105ERH Fumarylacetoacetate hydrolase EXD81_00125 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EXD81_00130 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination EXD81_00135 ENOG4108QY0 Membrane EXD81_00145 ENOG4108IG5 Transcriptional regulator EXD81_00155 ENOG4108KK1 membrane protein AbrB duplication EXD81_00160 ENOG4108INS Transcriptional regulator EXD81_00165 ENOG4107SCK Monooxygenase EXD81_00180 ENOG41060YP EXD81_00185 ENOG4106CAD Protein of unknown function (DUF3311) EXD81_00190 ENOG4105E1V na solute symporter EXD81_00195 ENOG4105K8R UPF0145 protein EXD81_00200 ENOG4105X3H Excalibur domain protein EXD81_00230 ENOG4105XVF Competence transcription factor EXD81_00255 ENOG4107ZYJ bioY protein EXD81_00270 ENOG4107TB6 phosphoglycerate mutase EXD81_00310 ENOG4105DF9 Lipoate-protein, ligase EXD81_00315 ENOG4108RQ5 Beta-lactamase domain-containing protein EXD81_00320 ENOG4106AXD EXD81_00330 ENOG4105DER m42 family EXD81_00345 ENOG4105ECB domain protein EXD81_00360 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EXD81_00365 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EXD81_00370 ENOG4105BZ4 penicillin-binding protein EXD81_00375 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EXD81_00405 ENOG4105K59 histidine triad (HIT) protein EXD81_00410 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EXD81_00415 ENOG4105NBU tryptophan transport protein EXD81_00465 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EXD81_00475 ENOG4105EQI Metal Dependent Phosphohydrolase EXD81_00480 ENOG4106D4I domain protein EXD81_00485 ENOG4107VRP DNA repair exonuclease EXD81_00490 ENOG4105RHA ABC transporter, permease EXD81_00515 ENOG4105NCW Trka-c domain protein EXD81_00520 ENOG4107S91 Sodium hydrogen exchanger EXD81_00530 ENOG4105D4P Coproporphyrinogen iii oxidase EXD81_00545 ENOG4105WZB UPF0342 protein EXD81_00585 ENOG4105BZ1 (ABC) transporter EXD81_00590 ENOG4105BZ1 (ABC) transporter EXD81_00600 ENOG4105IIP Membrane EXD81_00610 ENOG4105F0I Aminotransferase EXD81_00615 ENOG4107VMI polysaccharide deacetylase EXD81_00620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EXD81_00635 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EXD81_00640 ENOG4105WMR Protein CrcB homolog EXD81_00650 ENOG4105C37 (CBS) domain EXD81_00655 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase EXD81_00660 ENOG4105CHM Aminotransferase EXD81_00670 ENOG4105C37 (CBS) domain EXD81_00675 ENOG4105F6E Acyl-transferase EXD81_00680 ENOG4108AEY RNA polymerase sigma factor EXD81_00695 ENOG4105C8J )-transporter EXD81_00705 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EXD81_00710 ENOG4105BZN citrate synthase EXD81_00725 ENOG4105G6Z alkaline phosphatase EXD81_00730 ENOG4105ED1 spovr family EXD81_00770 ENOG4105WH1 Two component transcriptional regulator luxr family EXD81_00775 ENOG4105BZU Histidine kinase EXD81_00790 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EXD81_00800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EXD81_00805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EXD81_00810 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EXD81_00815 ENOG4107YBY Hydrolase EXD81_00820 ENOG41080XP Cbs domain EXD81_00830 ENOG4108YBP pseudouridine synthase EXD81_00885 ENOG4105VEQ Cold shock protein EXD81_00890 ENOG4108TU7 Inherit from COG: (ABC) transporter EXD81_00895 ENOG4105CJ1 ABC, transporter EXD81_00900 ENOG4105CZV ABC transporter EXD81_00905 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EXD81_00920 ENOG4105CS1 NAD(P)H quinone oxidoreductase EXD81_00925 ENOG4105C0R drug resistance transporter emrb qaca subfamily EXD81_00930 ENOG4105CW7 secretion protein, HlyD family EXD81_00935 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EXD81_00950 ENOG4105CYN Serine protein kinase EXD81_00970 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EXD81_00995 ENOG4105VZ8 Transcriptional regulator EXD81_01000 ENOG4107D63 EXD81_01005 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EXD81_01015 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EXD81_01020 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EXD81_01025 ENOG4105E2Y ABC, transporter EXD81_01045 ENOG4108JQ7 (ABC) transporter EXD81_01055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EXD81_01065 ENOG4105DEF Extracellular solute-binding protein, family 5 EXD81_01075 ENOG4105DNP FAD linked oxidase domain protein EXD81_01085 ENOG4105EC3 peptidase S51, dipeptidase E EXD81_01090 ENOG4107S6Z Na H antiporter EXD81_01195 ENOG4105TUA UPF0295 protein EXD81_01200 ENOG4105G5W regulator Fur family EXD81_01205 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EXD81_01210 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EXD81_01215 ENOG4107NBY Membrane EXD81_01240 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EXD81_01245 ENOG4106BXE EXD81_01255 ENOG41067AE Membrane-bound metal-dependent hydrolase EXD81_01260 ENOG4105EJV Membrane EXD81_01270 ENOG4105D74 hydrolase EXD81_01275 ENOG4106AKJ EXD81_01295 ENOG4108TCS Glutamyl endopeptidase EXD81_01315 ENOG410902V Modulates RecA activity (By similarity) EXD81_01320 ENOG4105ECP epimerase EXD81_01335 ENOG4107Y03 Nitroreductase EXD81_01340 ENOG4105JAB phenazine biosynthesis protein, phzf family EXD81_01350 ENOG410834F Transcriptional regulator EXD81_01355 ENOG4105C0R drug resistance transporter emrb qaca subfamily EXD81_01360 ENOG4108YYS metal-dependent hydrolase (By similarity) EXD81_01375 ENOG4105H93 Acyltransferase family EXD81_01385 ENOG4105U3E Transcriptional regulator EXD81_01390 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EXD81_01400 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EXD81_01410 ENOG4105BZ1 (ABC) transporter EXD81_01415 ENOG4105BZ1 (ABC) transporter EXD81_01430 ENOG4108Q3X Transcriptional regulator EXD81_01435 ENOG4105F8D glycoside hydrolase family 4 EXD81_01445 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EXD81_01455 ENOG4107QKR Dehydrogenase EXD81_01465 ENOG4107RUY (E1 component), alpha subunit EXD81_01490 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EXD81_01500 ENOG4105D7N magnesium and cobalt transport protein CorA EXD81_01510 ENOG4106KE4 Dehydrogenase EXD81_01540 ENOG4105UPD Calcium Proton EXD81_01545 ENOG4108ISG Major Facilitator EXD81_01550 ENOG4107U9T Pfam:Ribonuclease_BN EXD81_01560 ENOG4105KJF protein tyrosine phosphatase EXD81_01575 ENOG4105FF2 Type I DHQase EXD81_01580 ENOG4105E2X shikimate dehydrogenase EXD81_01585 ENOG4105ETE Transcriptional regulator (LacI family EXD81_01590 ENOG4107RKG DJ-1/PfpI family EXD81_01610 ENOG4108RCM Nitroreductase EXD81_01615 ENOG4107414 GntR family transcriptional regulator EXD81_01620 ENOG4105CG3 alpha amylase, catalytic region EXD81_01625 ENOG4105C5Y PTS System EXD81_01665 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EXD81_01685 ENOG4108RPX mosc domain containing protein EXD81_01690 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) EXD81_01715 ENOG4108MRH transcriptional regulatory protein EXD81_01750 ENOG4108J20 pectate lyase EXD81_01775 ENOG4105FDU atp-dependent rna helicase EXD81_01785 ENOG4105DXB Major Facilitator superfamily EXD81_01790 ENOG4107SWG transcriptional regulator MERR family EXD81_01795 ENOG4105C5H ABC transporter EXD81_01800 ENOG4107TVC Glycosyl transferase, family 2 EXD81_01805 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EXD81_01810 ENOG4105FKZ Methyl-accepting chemotaxis EXD81_01815 ENOG4105C26 Dehydrogenase EXD81_01820 ENOG4105CUB amino acid EXD81_01825 ENOG4105EU0 Major facilitator Superfamily EXD81_01830 ENOG41090R9 glycosyltransferase EXD81_01835 ENOG4107R51 Glycosyl transferase, family 2 EXD81_01840 ENOG41090R9 glycosyltransferase EXD81_01850 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EXD81_01855 ENOG4105E0M Sulfatase EXD81_01865 ENOG4108R1P EXD81_01870 ENOG41061H0 Monooxygenase EXD81_01875 ENOG41082F9 transcriptional regulator EXD81_01880 ENOG4106I4J membrane EXD81_01900 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EXD81_01905 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) EXD81_01910 ENOG4105H67 Protein of unknown function (DUF421) EXD81_01920 ENOG4105M18 -acetyltransferase EXD81_01940 ENOG4105CDY transcriptional regulatory protein EXD81_02015 ENOG4105CJ1 ABC, transporter EXD81_02025 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EXD81_02030 ENOG4105CBD Diacylglycerol kinase EXD81_02040 ENOG4108IG5 Transcriptional regulator EXD81_02045 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EXD81_02050 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EXD81_02055 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EXD81_02060 ENOG4105CK7 Sodium proline symporter EXD81_02090 ENOG4105C4R Atp-dependent dna helicase EXD81_02105 ENOG4105KGF protein, YerC YecD EXD81_02110 ENOG4108R5T secreted protein EXD81_02125 ENOG4105C12 Phosphoribosylglycinamide synthetase EXD81_02130 ENOG4105DC1 bifunctional purine biosynthesis protein purh EXD81_02135 ENOG4108V3E phosphoribosylglycinamide formyltransferase EXD81_02140 ENOG4105CXB phosphoribosylaminoimidazole synthetase EXD81_02150 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EXD81_02155 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EXD81_02160 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EXD81_02170 ENOG4105C83 adenylosuccinate lyase EXD81_02175 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EXD81_02180 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EXD81_02205 ENOG4105C7N Xanthine uracil vitamin C permease EXD81_02220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EXD81_02235 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EXD81_02245 ENOG4105C85 amino acid EXD81_02250 ENOG4107STQ Multicopper oxidase EXD81_02275 ENOG4105JVQ RNA Polymerase EXD81_02280 ENOG4108P49 AntiSigma factor EXD81_02300 ENOG4105DQX Zinc finger domain EXD81_02305 ENOG41087YS Phage shock protein A EXD81_02325 ENOG4105CPQ Dehydrogenase EXD81_02345 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EXD81_02350 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EXD81_02370 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EXD81_02375 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EXD81_02380 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EXD81_02385 ENOG4105C5H ABC transporter EXD81_02395 ENOG410801F ribosomal-protein-alanine acetyltransferase EXD81_02400 ENOG41072GX Peptidase M22 Glycoprotease EXD81_02405 ENOG4105K8N protein family UPF0079, ATPase EXD81_02450 ENOG4107QNK )-transporter EXD81_02470 ENOG4107QTZ amino acid EXD81_02490 ENOG4105DJ2 Major Facilitator Superfamily EXD81_02495 ENOG4105JXH GntR family transcriptional regulator EXD81_02500 ENOG4108TZY GntR Family Transcriptional Regulator EXD81_02505 ENOG4108SUT Major Facilitator Superfamily EXD81_02510 ENOG41090UD (LipO)protein EXD81_02515 ENOG4105FQP Beta-lactamase EXD81_02560 ENOG41090E6 transcriptional regulator MERR family EXD81_02580 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EXD81_02585 ENOG4105C2C drug resistance transporter, Bcr CflA EXD81_02595 ENOG4108JYZ YitT family EXD81_02615 ENOG4105EYF MMPL domain protein EXD81_02620 ENOG4108VB1 regulatoR EXD81_02625 ENOG4105ENE Histidine kinase EXD81_02635 ENOG4105PGS Spore coat protein EXD81_02640 ENOG4105E2A Dehydrogenase EXD81_02660 ENOG4105T38 integral membrane protein EXD81_02665 ENOG4108JGH Tetr family transcriptional regulator EXD81_02685 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EXD81_02695 ENOG4105VUF Transcriptional regulator EXD81_02700 ENOG4105DQ4 alcohol dehydrogenase EXD81_02725 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EXD81_02735 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein EXD81_02750 ENOG4105PGM cation diffusion facilitator family transporter EXD81_02760 ENOG4105DNP FAD linked oxidase domain protein EXD81_02775 ENOG41082W1 Cupin 2, conserved barrel domain protein EXD81_02785 ENOG4105IRW patatin-like phospholipase family protein EXD81_02790 ENOG4105DCM major facilitator superfamily EXD81_02815 ENOG41087NI Sulfite exporter TauE/SafE EXD81_02820 ENOG4105VFE sira family EXD81_02825 ENOG4107TPS domain protein EXD81_02830 ENOG4105VFE sira family EXD81_02840 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EXD81_02845 ENOG4105XTG Pfam:DUF156 EXD81_02850 ENOG4108VJ1 Transcriptional regulator (CarD family EXD81_02855 ENOG4105VEQ Cold shock protein EXD81_02890 ENOG4105DWF phosphomethylpyrimidine kinase EXD81_02925 ENOG4108Z40 Transcriptional regulator EXD81_02940 ENOG4108ZMQ domain protein EXD81_02965 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EXD81_02980 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EXD81_02995 ENOG410847I Transcriptional regulator, BadM Rrf2 family EXD81_03080 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) EXD81_03120 ENOG410906U SprT-like EXD81_03135 ENOG41064BQ Phosphatase EXD81_03145 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EXD81_03150 ENOG4105WN5 stage II sporulation protein EXD81_03160 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EXD81_03165 ENOG4105FUA antagonist EXD81_03170 ENOG4107MMM Anti-sigma-factor antagonist EXD81_03175 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EXD81_03185 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EXD81_03190 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EXD81_03195 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EXD81_03205 ENOG4105CKV Membrane EXD81_03210 ENOG410905X membrane-flanked domain protein EXD81_03215 ENOG4105C1J atp-dependent rna helicase EXD81_03220 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EXD81_03225 ENOG4105CPF Cell wall formation (By similarity) EXD81_03230 ENOG4105SZ6 Thioredoxin EXD81_03250 ENOG4105FDT acyl-CoA dehydrogenase EXD81_03265 ENOG4105CJ1 ABC, transporter EXD81_03270 ENOG4106F5Q Membrane EXD81_03275 ENOG4107QJT sodium dicarboxylate symporter EXD81_03280 ENOG4108MRH transcriptional regulatory protein EXD81_03285 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EXD81_03290 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EXD81_03305 ENOG41082W1 Cupin 2, conserved barrel domain protein EXD81_03310 ENOG4105QVS general stress protein EXD81_03315 ENOG4105EU9 EXD81_03320 ENOG4105KPY Small multidrug resistance protein EXD81_03325 ENOG4105RXJ EXD81_03330 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EXD81_03345 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EXD81_03395 ENOG4105C0X amino acid EXD81_03405 ENOG4107R8N Glycosyl transferase, family 2 EXD81_03435 ENOG4105VCH membrane EXD81_03445 ENOG410606W general stress protein EXD81_03460 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EXD81_03470 ENOG4105ETD TRANSCRIPTIONal EXD81_03475 ENOG4107QM2 Aldo Keto reductase EXD81_03480 ENOG4107RVG penicillin-binding protein EXD81_03485 ENOG41061CK Antibiotic biosynthesis monooxygenase EXD81_03495 ENOG4105XJB lipolytic protein G-D-S-L family EXD81_03500 ENOG4107258 Transcriptional regulator EXD81_03515 ENOG4105CFM UPF0317 protein EXD81_03520 ENOG4105C5A transporter EXD81_03525 ENOG4105E7W lamb ycsf family protein EXD81_03565 ENOG4108ZYE Transcriptional regulator EXD81_03570 ENOG4108T5E Copper resistance protein EXD81_03575 ENOG4105KTB nuclear export factor GLE1 EXD81_03580 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EXD81_03595 ENOG4108JPW Aminotransferase EXD81_03605 ENOG4105YVS arsR family transcriptional regulator EXD81_03610 ENOG41067V3 Antibiotic biosynthesis monooxygenase EXD81_03615 ENOG4108DBC nitroreductase EXD81_03620 ENOG4105R8C Transcriptional regulator EXD81_03635 ENOG4108IPW abc transporter atp-binding protein EXD81_03645 ENOG4105DHS permease protein EXD81_03650 ENOG4105CFH Aspartokinase EXD81_03680 ENOG4107WD8 ABC transporter, permease EXD81_03690 ENOG4108PGP mmge prpd family protein EXD81_03695 ENOG4105CH2 amidohydrolase EXD81_03705 ENOG4108HW4 amino acid AbC transporter EXD81_03710 ENOG4105EAB amino acid AbC transporter EXD81_03720 ENOG4105CPU Monooxygenase EXD81_03735 ENOG4105E1K spore germination protein EXD81_03750 ENOG4105DUX Transporter EXD81_03755 ENOG41069ZX EXD81_03760 ENOG41069ZX EXD81_03765 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EXD81_03770 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EXD81_03775 ENOG4106P55 Transcriptional regulator EXD81_03785 ENOG4105DRP amino acid AbC transporter EXD81_03790 ENOG4105CDA abc transporter atp-binding protein EXD81_03805 ENOG4105W8Z 4'-phosphopantetheinyl transferase EXD81_03815 ENOG4105SX7 Transporter EXD81_03850 ENOG4105KVH Transcriptional regulator EXD81_03875 ENOG4105CS2 ec 3.2.1.21 EXD81_03895 ENOG4105CKI cobalamin synthesis protein EXD81_03915 ENOG4108IFG nitrite reductase, (NAD(P)H) EXD81_03920 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EXD81_03930 ENOG4105CAY ferredoxin--nadp reductase EXD81_03935 ENOG4107YHD transcriptional regulator EXD81_03940 ENOG4105CK7 Sodium proline symporter EXD81_03945 ENOG4105C26 Dehydrogenase EXD81_03955 ENOG410756H nucleotidyltransferase EXD81_03960 ENOG4105I82 acetyl xylan esterase EXD81_03970 ENOG4105DJB Major Facilitator Superfamily EXD81_03975 ENOG4108WBH protein TIM barrel EXD81_03980 ENOG4105I1F Resistance protein EXD81_03990 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EXD81_03995 ENOG4105EIG urea carboxylase-associated protein 1 EXD81_04025 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EXD81_04055 ENOG4107SQ8 Glycine betaine EXD81_04060 ENOG4108IJ7 Glycine betaine EXD81_04065 ENOG41079KZ Major Facilitator Superfamily EXD81_04075 ENOG4108TTB tellurium resistance protein EXD81_04080 ENOG4107TS3 membrane protein, TerC EXD81_04085 ENOG4106FN3 tellurium resistance protein EXD81_04090 ENOG4106FN3 tellurium resistance protein EXD81_04095 ENOG4108N0M stress protein EXD81_04100 ENOG4105DEN Luciferase family EXD81_04115 ENOG4105DSE periplasmic solute binding protein EXD81_04125 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EXD81_04155 ENOG4107SET aldo keto reductase EXD81_04160 ENOG41060AI SEC-C motif EXD81_04165 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EXD81_04180 ENOG4105C0R drug resistance transporter emrb qaca subfamily EXD81_04185 ENOG4107EPV Aminotransferase class V EXD81_04190 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EXD81_04195 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EXD81_04200 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EXD81_04205 ENOG4105DGI Alkaline phosphatase EXD81_04230 ENOG4105XXY Thioredoxin EXD81_04235 ENOG4108VGI doxx family EXD81_04240 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EXD81_04250 ENOG41076HS cation diffusion facilitator family transporter EXD81_04280 ENOG4105CSV Glutaminase EXD81_04290 ENOG4108J5H Homocysteine s-methyltransferase EXD81_04310 ENOG4105C72 UPF0176 protein EXD81_04325 ENOG4107ZTW SNARE associated Golgi EXD81_04330 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EXD81_04335 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EXD81_04340 ENOG4107SCQ Iron-containing alcohol dehydrogenase EXD81_04390 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EXD81_04405 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) EXD81_04425 ENOG4106DDH Sporulation-specific SASP protein EXD81_04450 ENOG4105CJ1 ABC, transporter EXD81_04455 ENOG4105WH1 Two component transcriptional regulator luxr family EXD81_04475 ENOG41061AU MarR family Transcriptional regulator EXD81_04485 ENOG41067MG lrgb family EXD81_04495 ENOG4106K80 EXD81_04530 ENOG4105C8B TIGR00159 family EXD81_04540 ENOG4105EMN RNA polymerase sigma factor EXD81_04570 ENOG4105EWC Purine nucleoside phosphorylase EXD81_04600 ENOG4105EHZ conserved protein UCP016719 EXD81_04605 ENOG410874W AraC family transcriptional regulator EXD81_04625 ENOG4108SA1 esterase EXD81_04635 ENOG4105CHH sulfate transporter EXD81_04650 ENOG4108JPW Aminotransferase EXD81_04715 ENOG4108NMV polysaccharide deacetylase EXD81_04730 ENOG4105D1F ATP-binding protein EXD81_04750 ENOG4108I0C methyltransferase EXD81_04755 ENOG4108UJD 30S ribosomal protein S9 EXD81_04765 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EXD81_04775 ENOG4108JJB ABC transporter EXD81_04780 ENOG4108JJB ABC transporter EXD81_04785 ENOG4108ZT0 50S ribosomal protein l17 EXD81_04790 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EXD81_04795 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EXD81_04800 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EXD81_04810 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EXD81_04820 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EXD81_04825 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EXD81_04840 ENOG4105VPB 50S ribosomal protein L30 EXD81_04845 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EXD81_04850 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EXD81_04855 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EXD81_04860 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EXD81_04870 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EXD81_04885 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EXD81_04890 ENOG41082SA 50s ribosomal protein l29 EXD81_04895 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EXD81_04900 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EXD81_04905 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EXD81_04910 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EXD81_04915 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EXD81_04920 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EXD81_04930 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EXD81_04935 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EXD81_04940 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EXD81_04945 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EXD81_04950 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EXD81_04955 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EXD81_04960 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EXD81_04965 ENOG4105XPM ribosomal protein EXD81_04970 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EXD81_04975 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EXD81_04985 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EXD81_04990 ENOG4108VZM 50s ribosomal protein L10 EXD81_05000 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EXD81_05005 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EXD81_05030 ENOG4105C2N RNA methyltransferase TrmH family group 3 EXD81_05035 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EXD81_05050 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EXD81_05055 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EXD81_05060 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EXD81_05065 ENOG4105CTP PilT protein domain protein EXD81_05085 ENOG41066A3 ATP guanido phosphotransferase EXD81_05175 ENOG4105CRK lysyL-tRNA synthetase EXD81_05195 ENOG4105KRF dihydroneopterin aldolase EXD81_05205 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EXD81_05210 ENOG4105DDQ anthranilate synthase EXD81_05215 ENOG4105CRQ synthase (Component I) EXD81_05220 ENOG4105C6T cysteine synthase EXD81_05225 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EXD81_05230 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EXD81_05235 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EXD81_05245 ENOG4108UGV hypoxanthine phosphoribosyltransferase EXD81_05250 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EXD81_05280 ENOG41060GV RNA binding s1 domain protein EXD81_05295 ENOG4105VYY sporulation protein yabp EXD81_05300 ENOG41082I2 s4 domain protein EXD81_05315 ENOG4108M14 stage v sporulation protein t EXD81_05320 ENOG4108JA2 transcriptioN-repair coupling factor EXD81_05335 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EXD81_05340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EXD81_05345 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EXD81_05350 ENOG4105K4W Could be involved in septation (By similarity) EXD81_05355 ENOG4105KME endoribonuclease L-psp EXD81_05360 ENOG4105DFT pur operon repressor EXD81_05365 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EXD81_05370 ENOG4105XEW small acid-soluble spore protein EXD81_05375 ENOG4105W42 Veg protein EXD81_05400 ENOG4105F8V Hydrolase, tatD family EXD81_05410 ENOG4105KRN Transcriptional regulator, abrb family EXD81_05415 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EXD81_05420 ENOG4105VC4 domain protein EXD81_05425 ENOG41060K3 Methyltransferase EXD81_05435 ENOG4105MA4 psp1 domain protein EXD81_05450 ENOG4105X0R protein from nitrogen regulatory protein P-II EXD81_05455 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EXD81_05460 ENOG4105CXN decarboxylase EXD81_05465 ENOG4105CDW Resistance protein EXD81_05525 ENOG4105C6E dna polymerase iii EXD81_05535 ENOG4108Z6B deaminase EXD81_05540 ENOG4105GTG Isochorismatase EXD81_05545 ENOG4105VRS hydrolase family 18 EXD81_05555 ENOG4105ZMH deoxynucleoside kinase EXD81_05565 ENOG4105BZW Glycerate kinase EXD81_05570 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EXD81_05575 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EXD81_05580 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EXD81_05625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EXD81_05645 ENOG410848D S4 domain protein YaaA EXD81_05650 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EXD81_05655 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EXD81_05665 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EXD81_05680 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EXD81_05685 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EXD81_05700 ENOG4107QJE Chromosome Partitioning Protein EXD81_05710 ENOG4108ZDA Sporulation protein YyaC EXD81_05725 ENOG4105VDK protein, conserved in bacteria EXD81_05735 ENOG4105C3G gtp-binding protein EXD81_05740 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EXD81_05745 ENOG4108UUM single-stranded DNA-binding protein EXD81_05750 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EXD81_05760 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EXD81_05765 ENOG4105CGK Exodeoxyribonuclease III EXD81_05775 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EXD81_05785 ENOG4107FCW Abortive infection protein EXD81_05790 ENOG4105C7Z Conserved Protein EXD81_05795 ENOG4107Y9U Membrane EXD81_05805 ENOG4105DTD Dehydrogenase EXD81_05815 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EXD81_05825 ENOG41082BV acetyltransferase EXD81_05840 ENOG4105FS7 Transcriptional regulator EXD81_05845 ENOG4108TVJ Nitroreductase EXD81_05855 ENOG4107RSM transcriptional regulator EXD81_05860 ENOG4105D94 Major Facilitator Superfamily EXD81_05865 ENOG4108VP3 Lysine exporter protein (LysE YggA) EXD81_05870 ENOG4107V2S Transcriptional regulator EXD81_05885 ENOG4107XBN GntR Family Transcriptional Regulator EXD81_05890 ENOG4108HKT sucrose-6-phosphate hydrolase EXD81_05905 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EXD81_05930 ENOG4105BZR domain protein EXD81_05950 ENOG4105CPK Glycosyl transferase (Group 1 EXD81_05965 ENOG4107QPH glycogen) synthase EXD81_05970 ENOG4105EDW glycosyl transferase, family 39 EXD81_05995 ENOG4105CDU Replicative dna helicase EXD81_06000 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EXD81_06005 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EXD81_06035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EXD81_06040 ENOG4105BZU Histidine kinase EXD81_06055 ENOG4105Q2H domain protein EXD81_06070 ENOG41062D9 Histidine kinase EXD81_06075 ENOG4105D06 uba thif-type nad fad binding protein EXD81_06090 ENOG4105C5H ABC transporter EXD81_06100 ENOG4108JUB Transcriptional regulator EXD81_06105 ENOG41082BM Transcriptional regulator, arsr family EXD81_06115 ENOG4105C8Y Acetylornithine aminotransferase EXD81_06120 ENOG4108IQI permease EXD81_06125 ENOG41066UZ arginase EC 3.5.3.1 EXD81_06135 ENOG4105WQG acetyltransferase EXD81_06140 ENOG4105CPC Aldo Keto reductase EXD81_06145 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) EXD81_06170 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EXD81_06175 ENOG4108MIB EXD81_06240 ENOG4108XHQ (2Fe-2S)-binding domain protein EXD81_06245 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 EXD81_06255 ENOG4108JU3 Alkyl hydroperoxide reductase EXD81_06260 ENOG4105D3R alkyl hydroperoxide reductase EXD81_06270 ENOG41085PJ rdd domain containing protein EXD81_06275 ENOG4105F27 Major Facilitator EXD81_06280 ENOG4105WAB arsR family transcriptional regulator EXD81_06310 ENOG4105ECK Fatty Acid Desaturase EXD81_06320 ENOG4108S01 response regulator EXD81_06325 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EXD81_06335 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EXD81_06340 ENOG4107QNK )-transporter EXD81_06375 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EXD81_06385 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EXD81_06390 ENOG4105F0H myo-inositol catabolism protein EXD81_06395 ENOG4105WZ4 isomerase EXD81_06420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EXD81_06455 ENOG4108V5C ABC transporter EXD81_06485 ENOG410667J hydrolase EXD81_06490 ENOG4107RHR regulatoR EXD81_06495 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EXD81_06500 ENOG4105D9N nucleoside EXD81_06505 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EXD81_06515 ENOG4107W25 arginase agmatinase formiminoglutamase EXD81_06520 ENOG4105CI2 imidazolone-5-propionate hydrolase EXD81_06525 ENOG4105CGP Urocanate hydratase EXD81_06530 ENOG4105C84 Histidine ammonia-lyase EXD81_06540 ENOG4106Z5D Glycoside Hydrolase Family 43 EXD81_06545 ENOG4105M6F mutator MutT protein EXD81_06560 ENOG4105C5Y PTS System EXD81_06565 ENOG4105CS2 ec 3.2.1.21 EXD81_06570 ENOG4107YZX Universal stress protein EXD81_06580 ENOG4108NR7 pectate lyase EXD81_06625 ENOG4105C1J atp-dependent rna helicase EXD81_06630 ENOG4105DEU major facilitator superfamily EXD81_06635 ENOG4105CID antiterminator EXD81_06670 ENOG4105DHI Methyltransferase EXD81_06685 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EXD81_06690 ENOG4105CMR udp-glucose 4-epimerase EXD81_06700 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EXD81_06715 ENOG4107BJW polysaccharide deacetylase EXD81_06720 ENOG4105D2K citrate carrier protein EXD81_06725 ENOG4105C4M (Ubiquinol oxidase) subunit I EXD81_06730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EXD81_06740 ENOG4108JJ8 (ABC) transporter EXD81_06745 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EXD81_06755 ENOG4107QHE Choloylglycine hydrolase EXD81_06760 ENOG4105CH6 catalase EXD81_06770 ENOG4105DG6 mannose-6-phosphate isomerase EXD81_06775 ENOG4105EVU fructokinase EXD81_06785 ENOG4105CK1 PTS System EXD81_06790 ENOG4105VCP PTS System EXD81_06795 ENOG4105VZJ PTS System EXD81_06805 ENOG41082YX Transcriptional regulator, arsr family EXD81_06815 ENOG4105EHG Permease protein EXD81_06830 ENOG4105EMD TRANSCRIPTIONal EXD81_06835 ENOG4105VZJ PTS System EXD81_06840 ENOG4105CK1 PTS System EXD81_06850 ENOG4105F8D glycoside hydrolase family 4 EXD81_06855 ENOG4105CM2 brancheD-chain amino acid aminotransferase EXD81_06860 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EXD81_06865 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) EXD81_06870 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EXD81_06875 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EXD81_06890 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EXD81_06900 ENOG4105X1N Glycosyl transferase family 8 EXD81_06905 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EXD81_06910 ENOG4105CK1 PTS System EXD81_06920 ENOG4105DR4 Methyltransferase EXD81_06930 ENOG4107TXC Transcriptional regulator EXD81_06940 ENOG41067MG lrgb family EXD81_06945 ENOG4105VAW lrga family EXD81_06950 ENOG4105CMU LysR family (Transcriptional regulator EXD81_06955 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EXD81_06965 ENOG410650H (LipO)protein EXD81_06970 ENOG4105DBE peroxidase EXD81_06975 ENOG4107ZXU DSBA oxidoreductase EXD81_07000 ENOG4105WH5 Teichoic acid glycosylation protein EXD81_07015 ENOG4107BMA Transglycosylase associated protein EXD81_07020 ENOG4105E2S oxidase) subunit II EXD81_07025 ENOG4105BZ9 Cytochrome C oxidase, subunit I EXD81_07045 ENOG4105I4A GCN5-related N-acetyltransferase EXD81_07060 ENOG4108DBC nitroreductase EXD81_07065 ENOG4105DEN Luciferase family EXD81_07085 ENOG4105C5Y PTS System EXD81_07100 ENOG4105DWF phosphomethylpyrimidine kinase EXD81_07120 ENOG4108RJ9 Glycosyl transferase, family 2 EXD81_07125 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EXD81_07160 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EXD81_07165 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD EXD81_07175 ENOG4107TY6 Acylneuraminate cytidylyltransferase EXD81_07180 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG EXD81_07185 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EXD81_07190 ENOG4105C1B dTDP-glucose 4-6-dehydratase EXD81_07195 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EXD81_07200 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase EXD81_07210 ENOG4105D82 Glutamate dehydrogenase EXD81_07215 ENOG4105C26 Dehydrogenase EXD81_07265 ENOG4105CHM Aminotransferase EXD81_07275 ENOG4107JTW chlorite dismutase EXD81_07280 ENOG4108IJ2 phosphate acetyltransferase EXD81_07285 ENOG4105HMI Membrane EXD81_07290 ENOG4105DUM transcriptional regulator, lysR family EXD81_07295 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EXD81_07315 ENOG4108TU7 Inherit from COG: (ABC) transporter EXD81_07320 ENOG4105CJ1 ABC, transporter EXD81_07330 ENOG4105K7K Transcriptional regulator EXD81_07335 ENOG4108VCI transcription factor, rsfa family EXD81_07345 ENOG4105DCI Phosphohydrolase EXD81_07355 ENOG4105CUB amino acid EXD81_07365 ENOG41067TZ transcriptional regulator, MarR family EXD81_07370 ENOG41069HH 4-oxalocrotonate tautomerase EXD81_07375 ENOG4108Z4T Peptidase M50 EXD81_07380 ENOG4108XFG YwhD family EXD81_07390 ENOG4105BZ4 penicillin-binding protein EXD81_07395 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EXD81_07470 ENOG410684U Domain of unknown function (DUF1934) EXD81_07540 ENOG4105E5J UV damage endonuclease EXD81_07550 ENOG4105DF6 Fe-S oxidoreductase EXD81_07560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EXD81_07570 ENOG410812K response regulator receiver protein EXD81_07575 ENOG4105D2N Aldolase EXD81_07585 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EXD81_07600 ENOG41082DI 50s ribosomal protein l31 EXD81_07605 ENOG4107104 thymidine kinase EXD81_07610 ENOG4105C6K Malic enzyme EXD81_07615 ENOG4107TT2 Auxin Efflux Carrier EXD81_07625 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EXD81_07630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EXD81_07650 ENOG4108ZXQ stage ii sporulation protein r EXD81_07660 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EXD81_07665 ENOG410815N Probably functions as a manganese efflux pump (By similarity) EXD81_07670 ENOG4107WAU Protein tyrosine phosphatase EXD81_07675 ENOG4108YZG isomerase EXD81_07680 ENOG4108UIC UPF0340 protein EXD81_07690 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EXD81_07700 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EXD81_07720 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EXD81_07725 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EXD81_07730 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EXD81_07735 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EXD81_07745 ENOG4106778 Protein of unknown function (DUF1146) EXD81_07755 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EXD81_07775 ENOG4108TF4 von Willebrand factor, type A EXD81_07780 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EXD81_07785 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EXD81_07805 ENOG4108YZ9 Urea amidohydrolase subunit gamma EXD81_07810 ENOG4105KI2 Urea amidohydrolase subunit beta EXD81_07815 ENOG4105CQM Urea amidohydrolase subunit alpha EXD81_07820 ENOG4108Z40 Transcriptional regulator EXD81_07830 ENOG4107T94 Endo-14-beta-xylanase EXD81_07840 ENOG4106BRK EXD81_07860 ENOG4107TCE N-acetyltransferase EXD81_07865 ENOG4105FRN stage II sporulation protein EXD81_07875 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EXD81_07880 ENOG4105CNI cell division protein FtsW EXD81_07890 ENOG4105BZU Histidine kinase EXD81_07895 ENOG4105D3W isochorismatase EXD81_07905 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EXD81_07910 ENOG4105CZM Major Facilitator EXD81_07915 ENOG4107MII Sugar-specific transcriptional regulator TrmB EXD81_07920 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EXD81_07925 ENOG4105DFF Rod shape-determining protein mreb EXD81_07935 ENOG4105CGA flagellar basal-body rod protein FlgG EXD81_07945 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EXD81_07950 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EXD81_07965 ENOG4105Z8H single-stranded DNA-binding protein EXD81_07970 ENOG4105E98 transcriptional regulator DeoR family EXD81_07975 ENOG410667J hydrolase EXD81_07985 ENOG4105KBK Zinc finger, swim domain protein EXD81_08000 ENOG4105HTX biosynthesis protein EXD81_08005 ENOG4107YJ4 chain length determinant protein EXD81_08015 ENOG4105C6Y Udp-glucose 6-dehydrogenase EXD81_08020 ENOG4108XI2 Domain of unknown function (DUF1963) EXD81_08080 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EXD81_08085 ENOG4105FGV Chromate EXD81_08090 ENOG4105CAH Chromate EXD81_08100 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EXD81_08110 ENOG4107XC4 flavin reductase domain protein, FMN-binding EXD81_08140 ENOG4107RSM transcriptional regulator EXD81_08150 ENOG4107FQX Alpha-acetolactate decarboxylase EXD81_08155 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EXD81_08165 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EXD81_08170 ENOG4105CNN ABC, transporter EXD81_08175 ENOG4105C2J ABC transporter EXD81_08180 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EXD81_08190 ENOG4105ETE Transcriptional regulator (LacI family EXD81_08200 ENOG4105E1K spore germination protein EXD81_08210 ENOG4105N98 Capsule biosynthesis protein capB EXD81_08225 ENOG4105K4H Nlp p60 protein EXD81_08235 ENOG4105J7I hydrolase EXD81_08240 ENOG4108KGH TRANSCRIPTIONal EXD81_08245 ENOG4105C54 Major Facilitator superfamily EXD81_08250 ENOG4107R8N Glycosyl transferase, family 2 EXD81_08255 ENOG4108NHD germination protein EXD81_08270 ENOG4105DG6 mannose-6-phosphate isomerase EXD81_08310 ENOG4105EY8 ABC transporter EXD81_08350 ENOG4105PSV Polysaccharide Biosynthesis Protein EXD81_08355 ENOG4107RA4 Glycosyl transferase (Group 1 EXD81_08360 ENOG4105C6Y Udp-glucose 6-dehydrogenase EXD81_08365 ENOG4105QZI O-Antigen Polymerase EXD81_08380 ENOG4107EF8 Glycosyl transferase (Group 1 EXD81_08385 ENOG4105ESV Glycosyl transferase, family 4 EXD81_08390 ENOG4108KGH TRANSCRIPTIONal EXD81_08400 ENOG4105BZU Histidine kinase EXD81_08405 ENOG4105WH1 Two component transcriptional regulator luxr family EXD81_08425 ENOG41081UC Inherit from COG: Competence protein EXD81_08430 ENOG4105RU3 EXD81_08445 ENOG4105E1Q flagellar hook-associated protein EXD81_08450 ENOG4105DTJ flagellar hook-associated protein EXD81_08460 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EXD81_08465 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EXD81_08470 ENOG4105I03 Flagellin EXD81_08475 ENOG4107RT6 flagellar hook-associated EXD81_08480 ENOG4105MQ3 flagellar protein FliS EXD81_08495 ENOG4105MS2 ribosomal subunit Interface protein EXD81_08500 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EXD81_08520 ENOG4105CAK Cell division ATP-binding protein ftsE EXD81_08565 ENOG4105MKU Transcriptional regulator EXD81_08580 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EXD81_08585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EXD81_08600 ENOG4108PY7 EXD81_08605 ENOG41067S9 phage shock protein C, PspC EXD81_08610 ENOG41086DT Membrane protein of unknown function EXD81_08620 ENOG4105J7D transcriptional regulator EXD81_08625 ENOG4105FDP GntR family transcriptional regulator EXD81_08630 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EXD81_08640 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EXD81_08655 ENOG4108S4C acetyltransferase EXD81_08665 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EXD81_08670 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EXD81_08675 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EXD81_08680 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EXD81_08685 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EXD81_08690 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EXD81_08695 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EXD81_08700 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EXD81_08705 ENOG4105BZ1 (ABC) transporter EXD81_08710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EXD81_08715 ENOG4105BZU Histidine kinase EXD81_08730 ENOG4105C3M thioredoxin reductase EXD81_08740 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EXD81_08745 ENOG4105CHW UPF0052 protein EXD81_08750 ENOG4105CIE May be required for sporulation (By similarity) EXD81_08755 ENOG4105KRI phosphocarrier protein (HPr EXD81_08760 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EXD81_08765 ENOG4105GGE ribonuclease EXD81_08770 ENOG4105C5I Dehydrogenase EXD81_08780 ENOG4108V2W Carbonate dehydratase EXD81_08785 ENOG4105CHH sulfate transporter EXD81_08795 ENOG4108URH decarboxylase EXD81_08800 ENOG4105FKQ transcriptional regulator EXD81_08805 ENOG4108IUK alpha amylase, catalytic EXD81_08810 ENOG4107FKK extracellular solute-binding protein family 1 EXD81_08815 ENOG4105D56 permease protein EXD81_08820 ENOG4105EG2 ABC transporter, permease EXD81_08840 ENOG4107URF beta-phospho-glucomutase EXD81_08845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EXD81_08850 ENOG4105ETE Transcriptional regulator (LacI family EXD81_08855 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EXD81_08900 ENOG4105NI3 Protein of unknown function (DUF3237) EXD81_08905 ENOG4105PY6 Phenolic acid decarboxylase EXD81_08910 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EXD81_08920 ENOG4105NAE bifunctional deaminase-reductase domain protein EXD81_08925 ENOG4105EBR Carboxylesterase EXD81_08940 ENOG4108QV3 biosynthesis protein EXD81_08950 ENOG4108PQP glycosyl transferase group 1 EXD81_08955 ENOG4105K64 Glycosyl transferase, family 2 EXD81_08960 ENOG4108KMV Glycosyl transferase (Group 1 EXD81_08965 ENOG41068W6 Capsular polysaccharide biosynthesis protein EXD81_08970 ENOG4107QRS glycosyltransferase group 2 family protein EXD81_08990 ENOG4105D3Q Sugar transferase EXD81_08995 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EXD81_09000 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EXD81_09005 ENOG4108ZPC Polysaccharide pyruvyl transferase EXD81_09015 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EXD81_09020 ENOG4105DAA L-lactate EXD81_09025 ENOG4105JXH GntR family transcriptional regulator EXD81_09030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EXD81_09040 ENOG4107QR9 Iron-sulfur cluster binding protein EXD81_09050 ENOG4105C6Z Gluconate EXD81_09055 ENOG4105CMG Carbohydrate kinase EXD81_09060 ENOG4106KNT transcriptional regulator EXD81_09070 ENOG4107RT3 EamA-like transporter family EXD81_09085 ENOG4105CMD Transcriptional regulator, GntR family EXD81_09100 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EXD81_09120 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EXD81_09125 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EXD81_09140 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EXD81_09145 ENOG4108IAJ Nad-dependent epimerase dehydratase EXD81_09165 ENOG4105FJR Lmbe family EXD81_09195 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EXD81_09200 ENOG4107HG4 Transcriptional regulator EXD81_09205 ENOG4108IJ8 ABC transporter EXD81_09210 ENOG4105E90 ABC transporter EXD81_09215 ENOG4108HQR Glycine betaine EXD81_09220 ENOG4105R40 Glycine betaine carnitine choline EXD81_09225 ENOG4107HG4 Transcriptional regulator EXD81_09230 ENOG4108IJ8 ABC transporter EXD81_09235 ENOG4105E90 ABC transporter EXD81_09240 ENOG4108HQR Glycine betaine EXD81_09245 ENOG4105R40 Glycine betaine carnitine choline EXD81_09250 ENOG4105DA5 (ABC) transporter EXD81_09275 ENOG4105KVH Transcriptional regulator EXD81_09295 ENOG4105XZU Preprotein translocase, subunit SecG EXD81_09305 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EXD81_09310 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EXD81_09320 ENOG41067XF inhibitor EXD81_09325 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EXD81_09330 ENOG4108KSA LysR family transcriptional regulator EXD81_09335 ENOG4108XSB acetyltransferase, (GNAT) family EXD81_09360 ENOG4105CDA abc transporter atp-binding protein EXD81_09365 ENOG4105DEN Luciferase family EXD81_09380 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EXD81_09385 ENOG4105D9R oxidoreductase EXD81_09390 ENOG4105VPX protein, conserved in bacteria EXD81_09395 ENOG410681U heavy metal transport detoxification protein EXD81_09410 ENOG4107ZQN disulfide bond EXD81_09425 ENOG4105EN6 Membrane EXD81_09435 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EXD81_09450 ENOG4105EEQ Na H antiporter EXD81_09465 ENOG4108KYE ABC-2 type transporter EXD81_09475 ENOG4105CJ1 ABC, transporter EXD81_09480 ENOG4105BZU Histidine kinase EXD81_09485 ENOG4105WH1 Two component transcriptional regulator luxr family EXD81_09490 ENOG4105E0C molybdate abc transporter EXD81_09495 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EXD81_09500 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EXD81_09510 ENOG4107K5X Membrane-bound metal-dependent hydrolase EXD81_09525 ENOG4105D5Q Arginine ornithine antiporter EXD81_09535 ENOG4105DQ5 transport system permease protein EXD81_09545 ENOG4105E0A ABC, transporter EXD81_09555 ENOG4105F0F Oxalate decarboxylase EXD81_09565 ENOG4106DF4 Sigma-70, region 4 EXD81_09575 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EXD81_09585 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EXD81_09590 ENOG4105EWI Short-chain dehydrogenase reductase Sdr EXD81_09595 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EXD81_09600 ENOG4105EHG Permease protein EXD81_09605 ENOG4105E0A ABC, transporter EXD81_09610 ENOG4108WBT adenosyltransferase EXD81_09625 ENOG41087YS Phage shock protein A EXD81_09640 ENOG4105ENE Histidine kinase EXD81_09645 ENOG4105WH1 Two component transcriptional regulator luxr family EXD81_09675 ENOG41067SE Tetr family transcriptional regulator EXD81_09685 ENOG4105F3H Histidine kinase EXD81_09710 ENOG4105HUF DNA protection during starvation protein EXD81_09730 ENOG4105E0A ABC, transporter EXD81_09750 ENOG4105C5Q Transcriptional regulator EXD81_09760 ENOG41067TZ transcriptional regulator, MarR family EXD81_09790 ENOG4105CHU acetyl-coa acetyltransferase EXD81_09795 ENOG4105C1G acyl-Coa dehydrogenase EXD81_09800 ENOG41080E8 Transcriptional regulator, Spx MgsR family EXD81_09805 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EXD81_09830 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EXD81_09835 ENOG4108UMI ABC transporter, permease EXD81_09840 ENOG4105D01 (LipO)protein EXD81_09855 ENOG4105C3K feS assembly ATPase SufC EXD81_09860 ENOG4105JRK feS assembly protein SufD EXD81_09865 ENOG4105C9B Cysteine desulfurase EXD81_09870 ENOG4108UNV SUF system FeS assembly protein, NifU family EXD81_09875 ENOG4105DIW FeS assembly protein SUFB EXD81_09880 ENOG41083Q9 chitosanase EXD81_09895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EXD81_09900 ENOG4107VFR oxidoreductase EXD81_09905 ENOG4105PKS Excinuclease abc c subunit domain protein EXD81_09915 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine EXD81_09925 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EXD81_09930 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EXD81_09935 ENOG4108KPW sugar kinase EXD81_09940 ENOG4105FDP GntR family transcriptional regulator EXD81_09950 ENOG4108K8S endonuclease I EXD81_09960 ENOG4105C5R Aminotransferase EXD81_09970 ENOG4106CGH Phage Mu protein F like protein EXD81_09990 ENOG4105G9B Transcriptional regulator EXD81_09995 ENOG4105CD3 dihydroorotase EXD81_10005 ENOG4105I3N Conserved Protein EXD81_10015 ENOG4107R8B 5'-nucleotidase EXD81_10020 ENOG4108YTE sporulation protein YunB EXD81_10025 ENOG4105FAA peptidase M23 EXD81_10040 ENOG4105MMD transcriptional regulator EXD81_10050 ENOG4105D4U had-superfamily hydrolase, subfamily iia EXD81_10065 ENOG4105D6E homoserine dehydrogenase EXD81_10070 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EXD81_10075 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EXD81_10080 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EXD81_10085 ENOG41083MR nifu domain-containing protein EXD81_10100 ENOG4105ZKE UPF0349 protein EXD81_10110 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EXD81_10115 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EXD81_10160 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) EXD81_10175 ENOG4105CEP NADH dehydrogenase EXD81_10190 ENOG41069ER domain protein EXD81_10200 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EXD81_10220 ENOG4105NIV Esterase EXD81_10225 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EXD81_10230 ENOG4105E4F Isochorismate synthase EXD81_10235 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EXD81_10240 ENOG4105WQI isochorismatase EXD81_10250 ENOG4105WQT MbtH domain protein EXD81_10260 ENOG4105DCF alanine dehydrogenase EXD81_10265 ENOG4108K8K Transcriptional regulator EXD81_10300 ENOG410904N short-chain dehydrogenase reductase EXD81_10385 ENOG4105KA0 thioesterase Superfamily protein EXD81_10390 ENOG4105KJM monovalent cation h antiporter subunit g EXD81_10400 ENOG4105SC1 monovalent cation H antiporter subunit E EXD81_10405 ENOG4108JPZ Monovalent cation H antiporter subunit D EXD81_10415 ENOG4105HC0 Na H antiporter EXD81_10420 ENOG4105D65 subunit l EXD81_10435 ENOG4105UIB (ABC) transporter EXD81_10440 ENOG4108JQ9 ABC transporter EXD81_10445 ENOG4105DIH basic membrane EXD81_10450 ENOG4108MRH transcriptional regulatory protein EXD81_10465 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EXD81_10470 ENOG4105BZ4 penicillin-binding protein EXD81_10485 ENOG4105Y38 Kinase-associated protein B EXD81_10505 ENOG4108MUZ hydrolase EXD81_10510 ENOG4108ZB6 transcriptional regulator AsnC family EXD81_10515 ENOG4105CHM Aminotransferase EXD81_10525 ENOG4105WG9 Conserved Protein EXD81_10530 ENOG4107QW4 alcohol dehydrogenase EXD81_10555 ENOG4107QYV phosphohexose isomerase EXD81_10570 ENOG4107PBV potassium channel EXD81_10575 ENOG4107PBV potassium channel EXD81_10590 ENOG4105C37 (CBS) domain EXD81_10600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EXD81_10605 ENOG4105EA8 2-Nitropropane dioxygenase EXD81_10625 ENOG4105C8Q Methyl-accepting chemotaxis EXD81_10630 ENOG4105C8Q Methyl-accepting chemotaxis EXD81_10635 ENOG4105C8Q Methyl-accepting chemotaxis EXD81_10640 ENOG4108Z0Z intracellular protease Pfpi family EXD81_10645 ENOG4105EE0 oxidoreductase EXD81_10655 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EXD81_10665 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) EXD81_10670 ENOG410635T phage-like element pbsx protein EXD81_10680 ENOG41067QW Transcriptional regulator EXD81_10745 ENOG4105QBX endodeoxyribonuclease RusA EXD81_10945 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EXD81_10995 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EXD81_11000 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EXD81_11015 ENOG4105TRT Transcriptional regulator EXD81_11020 ENOG4105C26 Dehydrogenase EXD81_11030 ENOG4108VNY MOSC domain protein EXD81_11035 ENOG4106DF1 EXD81_11050 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EXD81_11190 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EXD81_11200 ENOG4108IPT Naphthoate synthase EXD81_11235 ENOG4105NRA 50s ribosomal protein l31 type b EXD81_11240 ENOG4108V2W Carbonate dehydratase EXD81_11245 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EXD81_11250 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EXD81_11265 ENOG4108RMU ferritin dps family protein EXD81_11280 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EXD81_11290 ENOG4105D2X ABC transporter substrate-binding protein EXD81_11305 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EXD81_11310 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EXD81_11315 ENOG4105CAQ asparagine synthetase EXD81_11330 ENOG4105E8V Alpha Beta Hydrolase Fold protein EXD81_11360 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EXD81_11365 ENOG4105DVE abc transporter atp-binding protein EXD81_11380 ENOG4105C19 ABC transporter EXD81_11385 ENOG4107R34 abc transporter permease protein EXD81_11395 ENOG4105EWM Histidine kinase EXD81_11400 ENOG4105C19 ABC transporter EXD81_11415 ENOG410605W Major Facilitator EXD81_11420 ENOG4105BZU Histidine kinase EXD81_11430 ENOG4105C8T Leucyl-tRNA synthetase EXD81_11435 ENOG41085GJ domain protein EXD81_11450 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component EXD81_11470 ENOG4105C94 Transporter EXD81_11490 ENOG4105YW5 deoR family transcriptional regulator EXD81_11515 ENOG4105C6T cysteine synthase EXD81_11520 ENOG4107F58 2'-5' rna ligase EXD81_11535 ENOG4108V15 phosphotransferase enzyme family EXD81_11550 ENOG4105C8F Beta-lactamase domain protein EXD81_11555 ENOG4105C6K Malic enzyme EXD81_11570 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EXD81_11585 ENOG4108VDD TRNA binding domain protein EXD81_11595 ENOG4105DFU Cell wall formation (By similarity) EXD81_11615 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EXD81_11620 ENOG4105ETE Transcriptional regulator (LacI family EXD81_11625 ENOG4105ETE Transcriptional regulator (LacI family EXD81_11630 ENOG4107R0U MotA TolQ exbB proton channel EXD81_11635 ENOG4105ER2 Ompa motb domain protein EXD81_11640 ENOG4105DGU Histone deacetylase EXD81_11645 ENOG4105W87 Cbs domain EXD81_11650 ENOG4105F1V Acetoin utilization protein EXD81_11680 ENOG4108NGU Transcriptional regulator EXD81_11700 ENOG4108Z0Z intracellular protease Pfpi family EXD81_11710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EXD81_11775 ENOG4105C26 Dehydrogenase EXD81_11780 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EXD81_11800 ENOG4105U5Y Transcriptional regulator EXD81_11825 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EXD81_11835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EXD81_11840 ENOG4105EFZ amidohydrolase EXD81_11845 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EXD81_11850 ENOG4105D07 Signal peptide peptidase, SppA EXD81_11855 ENOG4105VK3 rdd domain containing protein EXD81_11870 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EXD81_11880 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EXD81_11885 ENOG4105EPU Molybdenum cofactor synthesis domain protein EXD81_11905 ENOG4105E8R UPF0173 metal-dependent hydrolase EXD81_11925 ENOG4106EVM EXD81_11935 ENOG4105VV2 EXD81_11945 ENOG4105C6K Malic enzyme EXD81_11950 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EXD81_11955 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EXD81_11960 ENOG4105CTQ phosphohexokinase EXD81_11970 ENOG4105FS0 cytoplasmic membrane protein EXD81_11975 ENOG4108REF Sporulation integral membrane protein ytvi EXD81_11990 ENOG4105BZN citrate synthase EXD81_11995 ENOG4108HMX isocitrate dehydrogenase (NADP) EXD81_12005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EXD81_12015 ENOG4105C2M dna polymerase I EXD81_12020 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EXD81_12030 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EXD81_12035 ENOG4105CV8 reductase EXD81_12040 ENOG4105F27 Major Facilitator EXD81_12045 ENOG4105KVH Transcriptional regulator EXD81_12050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EXD81_12055 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EXD81_12080 ENOG4108TDW sporulation protein YtxC EXD81_12085 ENOG4105C22 threonyL-tRNA synthetase EXD81_12090 ENOG4105U0R haloacid dehalogenase-like hydrolase EXD81_12095 ENOG4108HRK Histidine kinase EXD81_12100 ENOG4105DY9 regulatoR EXD81_12110 ENOG41067MG lrgb family EXD81_12115 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EXD81_12120 ENOG4105VJV 50s ribosomal protein L35 EXD81_12125 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EXD81_12130 ENOG410696E Membrane EXD81_12140 ENOG4105CN9 Peptidase m42 family protein EXD81_12145 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase EXD81_12160 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EXD81_12170 ENOG4108MDK Dehydrogenase EXD81_12190 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EXD81_12200 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EXD81_12205 ENOG4105CQB FAD linked oxidase domain protein EXD81_12235 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EXD81_12250 ENOG4105DCG PHP domain protein EXD81_12255 ENOG4105C98 muts2 protein EXD81_12265 ENOG4108YV3 Protein of unknown function (DUF2711) EXD81_12270 ENOG4105CEY Amp-dependent synthetase and ligase EXD81_12280 ENOG41060WC Enoyl-CoA hydratase EXD81_12285 ENOG4105BZJ Electron transfer flavoprotein EXD81_12290 ENOG4105C10 Electron transfer flavoprotein EXD81_12295 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EXD81_12300 ENOG4105K63 Thioredoxin EXD81_12315 ENOG4105CFH Aspartokinase EXD81_12325 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EXD81_12335 ENOG4105E33 succinate dehydrogenase EXD81_12360 ENOG41067QW Transcriptional regulator EXD81_12365 ENOG4106A7E Transcriptional regulator EXD81_12370 ENOG4105WXW Antirepressor EXD81_12400 ENOG4108NF7 phage-type endonuclease EXD81_12405 ENOG4108PNI recT protein EXD81_12415 ENOG4106CVF DNA replication protein EXD81_12520 ENOG4107KNS EXD81_12650 ENOG41068G1 EXD81_12730 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EXD81_12735 ENOG4107Y5K Resolvase EXD81_12740 ENOG4105PFC Transcriptional regulator EXD81_12750 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EXD81_12755 ENOG4108XJQ germination protein EXD81_12760 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EXD81_12765 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EXD81_12770 ENOG4105M59 Phosphodiesterase, mj0936 family EXD81_12800 ENOG4108ZP8 Acetolactate synthase small subunit EXD81_12815 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EXD81_12820 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EXD81_12825 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EXD81_12835 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EXD81_12840 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EXD81_12850 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EXD81_12855 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EXD81_12865 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EXD81_12875 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EXD81_12885 ENOG4105D52 delta-aminolevulinic acid dehydratase EXD81_12895 ENOG41068KH stage VI sporulation protein D EXD81_12910 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EXD81_12915 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EXD81_12930 ENOG4108Z03 MAF-like protein EXD81_12940 ENOG4108C33 Resolvase EXD81_12950 ENOG4108IMY Transcriptional regulator EXD81_12970 ENOG4108ZUE Phage regulatory protein rha EXD81_12995 ENOG4105CDU Replicative dna helicase EXD81_13175 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase EXD81_13200 ENOG4105DFF Rod shape-determining protein mreb EXD81_13205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EXD81_13210 ENOG4105YHC Rod shape-determining protein MreD EXD81_13215 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EXD81_13220 ENOG4107QMS site-determining protein EXD81_13235 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EXD81_13240 ENOG4105X36 (ribosomal) protein EXD81_13245 ENOG4105K46 50S ribosomal protein l27 EXD81_13255 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EXD81_13265 ENOG4105CQC Prephenate dehydratase EXD81_13280 ENOG4108IYU L-aspartate oxidase EXD81_13290 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EXD81_13295 ENOG4106678 morphogenetic protein associated with SpoVID EXD81_13325 ENOG41061AI Protein of unknown function (DUF2905) EXD81_13335 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EXD81_13340 ENOG4105VIE preprotein translocase, subunit YajC EXD81_13345 ENOG4105NAP EXD81_13365 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EXD81_13370 ENOG4105NCW Trka-c domain protein EXD81_13375 ENOG41067VP Protein of unknown function (DUF1049) EXD81_13390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EXD81_13395 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EXD81_13400 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EXD81_13405 ENOG4105CUT histidyl-tRNA synthetase EXD81_13410 ENOG4105C9M aspartyl-trna synthetase EXD81_13420 ENOG4105CUZ uba thif-type nad fad binding protein EXD81_13435 ENOG4105C3J Cysteine desulfurase EXD81_13440 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EXD81_13450 ENOG4105C7H Helicase, RecD TraA family EXD81_13460 ENOG41060CR EXD81_13470 ENOG4105DRP amino acid AbC transporter EXD81_13475 ENOG4105EAD ABC transporter EXD81_13485 ENOG4105CDA abc transporter atp-binding protein EXD81_13495 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EXD81_13500 ENOG4105VBH UPF0297 protein EXD81_13505 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EXD81_13520 ENOG4108VQJ O-methyltransferase EXD81_13525 ENOG4105XYU peptidase (U32 family) EXD81_13540 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EXD81_13545 ENOG4107XRG penicillin-binding protein EXD81_13575 ENOG4105C28 cystathionine EXD81_13590 ENOG4108JB9 formate dehydrogenase EXD81_13595 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EXD81_13620 ENOG41082JN Transcriptional regulator EXD81_13625 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EXD81_13635 ENOG4107RSM transcriptional regulator EXD81_13640 ENOG4108Z66 YbaK ebsC protein EXD81_13655 ENOG4105DM4 PTS System EXD81_13660 ENOG4105DG6 mannose-6-phosphate isomerase EXD81_13705 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EXD81_13755 ENOG41080BT SNARE associated Golgi EXD81_13775 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EXD81_13780 ENOG4105CQW ribosome biogenesis GTPase YqeH EXD81_13785 ENOG4105E2X shikimate dehydrogenase EXD81_13790 ENOG410812S Rna-binding protein EXD81_13795 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EXD81_13800 ENOG4108WF2 Metal Dependent Phosphohydrolase EXD81_13810 ENOG4108D32 Methyltransferase EXD81_13820 ENOG4105KQC Competence protein EXD81_13825 ENOG4108UK2 deaminase EXD81_13870 ENOG4105CSA Coproporphyrinogen iii oxidase EXD81_13875 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EXD81_13880 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EXD81_13890 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EXD81_13895 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EXD81_13900 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EXD81_13905 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EXD81_13920 ENOG4105KTH gatB Yqey EXD81_13925 ENOG4105F7J membrane-bound serine protease EXD81_13930 ENOG4105DI5 UPF0365 protein EXD81_13940 ENOG41068P3 sporulation protein YqfC EXD81_13950 ENOG4105C9A Phoh family EXD81_13955 ENOG4105CTJ Metal Dependent Phosphohydrolase EXD81_13960 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EXD81_13965 ENOG4107YR5 Diacylglycerol kinase EXD81_13970 ENOG4105KG3 cytidine deaminase EXD81_13985 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) EXD81_13990 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EXD81_13995 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EXD81_14005 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EXD81_14010 ENOG4108UPT UPF0178 protein EXD81_14015 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EXD81_14020 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EXD81_14035 ENOG4105EGD dinuclear metal center protein, YbgI family EXD81_14040 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EXD81_14055 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EXD81_14060 ENOG41069ZM Protein of unknown function (DUF2624) EXD81_14065 ENOG4108JYZ YitT family EXD81_14070 ENOG4105N80 Ferric uptake regulator, Fur family EXD81_14075 ENOG4108U5J '-nucleotidase EXD81_14080 ENOG41063Y9 EXD81_14100 ENOG4105SXS Protein of unknown function (DUF456) EXD81_14105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EXD81_14115 ENOG4107RF6 penicillin-binding protein EXD81_14125 ENOG4105C8U phosphate abc transporter EXD81_14130 ENOG4105E2Z phosphate ABC transporter (Permease EXD81_14135 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EXD81_14145 ENOG41068DG YceG-like family EXD81_14155 ENOG4105WDJ 50S ribosomal protein L33 EXD81_14160 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EXD81_14205 ENOG4105C5X domain protein EXD81_14290 ENOG4105VFR signal peptidase EXD81_14300 ENOG4108IMY Transcriptional regulator EXD81_14320 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EXD81_14330 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EXD81_14335 ENOG4105WZW rhodanese family EXD81_14340 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EXD81_14360 ENOG4105CBJ Metal-dependent enzyme EXD81_14370 ENOG4105DC7 peptidase M24 EXD81_14375 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EXD81_14385 ENOG4105CD2 stage iii sporulation protein aa EXD81_14390 ENOG4105KR5 Stage iii sporulation protein EXD81_14400 ENOG4105KQ4 Stage iii sporulation protein ad EXD81_14435 ENOG4108ZSR alkaline shock protein EXD81_14440 ENOG4105M7K Involved in the transcription termination process (By similarity) EXD81_14450 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EXD81_14455 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EXD81_14460 ENOG4105CTB Polyprenyl synthetase EXD81_14465 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EXD81_14470 ENOG4105DX0 Hemolysin A EXD81_14475 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EXD81_14490 ENOG4107QQR Sporulation EXD81_14500 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EXD81_14515 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EXD81_14535 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EXD81_14550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EXD81_14565 ENOG4105DXD 2-methylcitrate dehydratase EXD81_14570 ENOG4105CR4 methylisocitrate lyase EXD81_14575 ENOG4106CCJ Protein of unknown function (DUF2627) EXD81_14580 ENOG4108JUB Transcriptional regulator EXD81_14590 ENOG4107RDP Dehydrogenase EXD81_14610 ENOG4105CPP Dehydrogenase, E1 component EXD81_14615 ENOG4105C7S Dehydrogenase EXD81_14620 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EXD81_14625 ENOG4108Y6J UPF0403 protein EXD81_14630 ENOG4108HW3 (ABC) transporter EXD81_14635 ENOG4105E5Q amino acid AbC transporter EXD81_14640 ENOG4105CDA abc transporter atp-binding protein EXD81_14645 ENOG4108QEG Membrane EXD81_14650 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EXD81_14665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EXD81_14680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EXD81_14685 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EXD81_14690 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EXD81_14695 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EXD81_14700 ENOG410861F 50S ribosomal protein L33 EXD81_14710 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EXD81_14720 ENOG4108K70 Transcriptional regulator EXD81_14730 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EXD81_14760 ENOG4105CHR reductase EXD81_14770 ENOG4105C0W non-ribosomal peptide synthetase EXD81_14800 ENOG4106A3M Cytochrome p-450 EXD81_14810 ENOG4108KQ6 Enoyl-CoA hydratase EXD81_14815 ENOG4105II7 pyrroline-5-carboxylate reductase EXD81_14835 ENOG4105CS9 pantothenic acid kinase EXD81_14840 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase EXD81_14865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EXD81_14870 ENOG4108XET gCN5-related N-acetyltransferase EXD81_14875 ENOG4105KAC Antibiotic biosynthesis monooxygenase EXD81_14880 ENOG4105RHY Pfam:UPF0157 EXD81_14885 ENOG4106HZJ EXD81_14905 ENOG4105CPC Aldo Keto reductase EXD81_14925 ENOG4108IMY Transcriptional regulator EXD81_14930 ENOG4105HDK L-asparaginase EXD81_14935 ENOG4108IJ0 Aspartate ammonia-lyase EXD81_14960 ENOG4105MZ9 stage II sporulation protein m EXD81_14965 ENOG4105I3K Ferric uptake regulator, Fur family EXD81_14980 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EXD81_14985 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EXD81_14995 ENOG41082AN stage II sporulation protein EXD81_15000 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EXD81_15020 ENOG41090VF Stage v sporulation protein ac EXD81_15035 ENOG4105G6R Stage v sporulation protein ae EXD81_15050 ENOG4105PTM secreted protein EXD81_15055 ENOG4107ZE5 PPIases accelerate the folding of proteins EXD81_15080 ENOG4108R6K riboflavin synthase, subunit alpha EXD81_15085 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EXD81_15090 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EXD81_15115 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EXD81_15130 ENOG4108JIC nucleoside recognition domain protein EXD81_15140 ENOG4105FE9 pseudouridine synthase EXD81_15150 ENOG4107TWT Cytochrome c biogenesis protein EXD81_15155 ENOG4105CRE cytochrome C EXD81_15160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EXD81_15205 ENOG4105I7S Abortive infection protein EXD81_15220 ENOG4107RGJ metallophosphoesterase EXD81_15235 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EXD81_15290 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EXD81_15305 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EXD81_15310 ENOG4105K70 DNA-binding protein EXD81_15315 ENOG4105EUJ GTP cyclohydrolase i EXD81_15320 ENOG4105WP2 Tryptophan RNA-binding attenuator protein EXD81_15325 ENOG4105XXQ heptaprenyl diphosphate synthase component I EXD81_15330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EXD81_15335 ENOG4105EAH synthase EXD81_15340 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EXD81_15345 ENOG4105BZU Histidine kinase EXD81_15350 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EXD81_15360 ENOG4105KHN chorismate mutase EXD81_15365 ENOG4105CRQ synthase (Component I) EXD81_15380 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EXD81_15385 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EXD81_15395 ENOG4105CIH Imidazole acetol-phosphate transaminase EXD81_15405 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EXD81_15410 ENOG41068YB TPR repeat-containing protein EXD81_15430 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EXD81_15450 ENOG4105F0F Oxalate decarboxylase EXD81_15455 ENOG4108JYZ YitT family EXD81_15460 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EXD81_15465 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EXD81_15470 ENOG4108Z5K methylglyoxal synthase EXD81_15475 ENOG4105FJR Lmbe family EXD81_15480 ENOG4105CPK Glycosyl transferase (Group 1 EXD81_15485 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EXD81_15495 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EXD81_15505 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EXD81_15515 ENOG4105YAC EXD81_15525 ENOG4105CHM Aminotransferase EXD81_15530 ENOG4105C5S asparaginyl-tRNA synthetase EXD81_15540 ENOG4105CSM endonuclease III EXD81_15550 ENOG4105BZ4 penicillin-binding protein EXD81_15555 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) EXD81_15600 ENOG4108I5C dEAD DEAH box helicase EXD81_15620 ENOG4108UKS UPF0398 protein EXD81_15625 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) EXD81_15635 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EXD81_15650 ENOG4105DVT helicase EXD81_15665 ENOG4105C2W permease EXD81_15735 ENOG41081VK Ribonuclease EXD81_15780 ENOG4105CVG Homoserine O-transsuccinylase EXD81_15785 ENOG4108V06 Glutathione peroxidase EXD81_15800 ENOG4105C01 Dihydroxy-acid dehydratase EXD81_15805 ENOG4108Y6J UPF0403 protein EXD81_15810 ENOG4107YX5 Pfam:DUF548 EXD81_15820 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EXD81_15825 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EXD81_15835 ENOG4108UT2 hemolysin iii EXD81_15845 ENOG4105C7B Threonine dehydratase EXD81_15860 ENOG41090WU lipolytic protein G-D-S-L family EXD81_15865 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EXD81_15875 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EXD81_15880 ENOG4105E0X reductase EXD81_15885 ENOG4105C5E polysaccharide biosynthesis protein EXD81_15925 ENOG4105FTQ Dna gyrase EXD81_15930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EXD81_15945 ENOG4107S4Y M20 DapE family protein YgeY EXD81_15950 ENOG4108TSC N-acetyltransferase EXD81_15955 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EXD81_15985 ENOG410841Q phosphoesterase PA-phosphatase related protein EXD81_15990 ENOG4106Z5R EXD81_16000 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EXD81_16060 ENOG4105FBA Phospholipase Carboxylesterase EXD81_16080 ENOG41090U3 tautomerase EXD81_16115 ENOG4106SCS STAS domain EXD81_16120 ENOG4107QMU Mate efflux family protein EXD81_16130 ENOG41087PP glycosyltransferase MGT family EXD81_16145 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EXD81_16155 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EXD81_16160 ENOG4105C7S Dehydrogenase EXD81_16170 ENOG4105C09 Bile acid EXD81_16185 ENOG4105EWU Squalene--hopene cyclase EXD81_16235 ENOG4105SCY DNAK suppressor EXD81_16240 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EXD81_16250 ENOG4105C9U ATP-dependent DNA helicase RecQ EXD81_16255 ENOG41069ER domain protein EXD81_16290 ENOG4105KTU Transcriptional regulator, arsr family EXD81_16300 ENOG4108W8B Beta-lactamase domain protein EXD81_16310 ENOG4105FTV AraC Family Transcriptional Regulator EXD81_16315 ENOG4108Z7R Chaperone CsaA EXD81_16325 ENOG4106ANW SMI1_KNR4 EXD81_16355 ENOG4108M3J Dehydrogenase EXD81_16360 ENOG4107U6E carbohydrate kinase FGGY EXD81_16405 ENOG4105C5Q Transcriptional regulator EXD81_16415 ENOG4105BZ8 glutamate synthase EXD81_16425 ENOG4105CB2 alcohol dehydrogenase EXD81_16430 ENOG4108KSA LysR family transcriptional regulator EXD81_16435 ENOG4105C22 threonyL-tRNA synthetase EXD81_16440 ENOG4105WAB arsR family transcriptional regulator EXD81_16445 ENOG4108RWP Major Facilitator Superfamily protein EXD81_16450 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EXD81_16475 ENOG4107QJQ Mate efflux family protein EXD81_16480 ENOG4108N2V aldose 1-epimerase EXD81_16485 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EXD81_16505 ENOG4105C0W non-ribosomal peptide synthetase EXD81_16520 ENOG4106U2H Protein of unknown function (DUF1360) EXD81_16525 ENOG4105F32 YngK protein EXD81_16530 ENOG4105C1G acyl-Coa dehydrogenase EXD81_16535 ENOG4105CEY Amp-dependent synthetase and ligase EXD81_16540 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EXD81_16545 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EXD81_16550 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EXD81_16555 ENOG4105E39 Enoyl-CoA hydratase EXD81_16560 ENOG4107QX3 carboxylase EXD81_16565 ENOG4107T5V SNARE associated Golgi EXD81_16570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EXD81_16580 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) EXD81_16585 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EXD81_16590 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EXD81_16595 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EXD81_16600 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EXD81_16610 ENOG4105CY2 Citrate transporter EXD81_16615 ENOG4105D6N CoA-transferase, subunit a EXD81_16620 ENOG4108IIH CoA-transferase subunit B EXD81_16625 ENOG4105DTD Dehydrogenase EXD81_16650 ENOG4107SYN Glycosyl hydrolases family 43 EXD81_16695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EXD81_16725 ENOG4108I5G Major Facilitator superfamily EXD81_16735 ENOG4105DMW Dehydrogenase reductase EXD81_16740 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EXD81_16745 ENOG4108UHU Aldolase EXD81_16750 ENOG4105CPQ Dehydrogenase EXD81_16780 ENOG4105K4P CoA-binding domain protein EXD81_16785 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EXD81_16790 ENOG4105W8X HesB YadR YfhF-family protein EXD81_16795 ENOG4105MI2 EXD81_16805 ENOG41067CD Small, acid-soluble spore protein Tlp EXD81_16820 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EXD81_16825 ENOG4108I0Z Aconitate hydratase EXD81_16860 ENOG4107QIV Cytochrome c biogenesis protein EXD81_16870 ENOG4105VXM UPF0154 protein EXD81_16885 ENOG4105VPS UPF0291 protein EXD81_16890 ENOG4108SVB resolvase EXD81_16900 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EXD81_16920 ENOG4105K7W phage-related replication protein EXD81_16930 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EXD81_16960 ENOG4108M1A Chitin-binding protein EXD81_16995 ENOG4105EPI acetyltransferase, (GNAT) family EXD81_17015 ENOG4105DQ4 alcohol dehydrogenase EXD81_17050 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EXD81_17055 ENOG4105CMG Carbohydrate kinase EXD81_17060 ENOG4105C93 Xylose Isomerase EXD81_17075 ENOG4105CT4 transporter EXD81_17085 ENOG4105C5F glutamine synthetase EXD81_17095 ENOG4105CXI aluminum resistance protein EXD81_17100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EXD81_17105 ENOG4106F1P AAA ATPase, central domain protein EXD81_17115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EXD81_17120 ENOG4105U6W MutT NUDIX family protein EXD81_17155 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EXD81_17180 ENOG4108X3M OsmC Ohr family protein EXD81_17185 ENOG4105K7W phage-related replication protein EXD81_17195 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EXD81_17215 ENOG4106A3M Cytochrome p-450 EXD81_17250 ENOG4108MGH Enoyl-CoA hydratase EXD81_17255 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase EXD81_17260 ENOG41062T2 Acyl carrier protein EXD81_17265 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EXD81_17270 ENOG4108JA1 polyketide synthase EXD81_17275 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EXD81_17295 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EXD81_17320 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EXD81_17325 ENOG4105CPQ Dehydrogenase EXD81_17330 ENOG4105MCT stage V sporulation protein S EXD81_17335 ENOG4105D48 metallophosphoesterase EXD81_17345 ENOG4108A04 Beta-lactamase EXD81_17350 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EXD81_17355 ENOG4105CEV competence damage-inducible protein EXD81_17360 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EXD81_17375 ENOG4105XZV Protein of unknown function (DUF3243) EXD81_17380 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EXD81_17410 ENOG4105FDP GntR family transcriptional regulator EXD81_17425 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EXD81_17435 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EXD81_17445 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EXD81_17455 ENOG4105E35 Dipicolinate synthase subunit A EXD81_17465 ENOG4105C1V Peptidase, M16 EXD81_17475 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EXD81_17480 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EXD81_17485 ENOG4105DTN riboflavin biosynthesis protein ribF EXD81_17490 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EXD81_17495 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EXD81_17500 ENOG4105W7A Protein of unknown function (DUF503) EXD81_17505 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EXD81_17510 ENOG4105VHM ribosomal protein EXD81_17515 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EXD81_17520 ENOG4105CHV Transcription elongation factor NusA EXD81_17525 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EXD81_17535 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EXD81_17540 ENOG4105DZP Membrane-associated zinc metalloprotease EXD81_17555 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EXD81_17560 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EXD81_17565 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EXD81_17575 ENOG4105CE9 30S ribosomal protein S2 EXD81_17585 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EXD81_17590 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EXD81_17600 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EXD81_17605 ENOG4105CBS Chea signal transduction histidine kinase EXD81_17610 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EXD81_17620 ENOG4105FZW flagellar biosynthesis regulator FlhF EXD81_17640 ENOG4105VS8 Flagellar biosynthetic protein fliq EXD81_17645 ENOG4105CN7 Flagellar biosynthetic protein FliP EXD81_17655 ENOG4107YTP response regulator receiver protein EXD81_17660 ENOG4105DD5 Flagellar motor switch protein EXD81_17675 ENOG41068WV flagellar FlbD family protein EXD81_17680 ENOG4108JQA flagellar EXD81_17685 ENOG410822I Flagellar hook capping protein EXD81_17690 ENOG410696Y Flagellar hook-length control protein EXD81_17700 ENOG4106YF4 Flagellar biosynthesis chaperone EXD81_17715 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EXD81_17720 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EXD81_17725 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EXD81_17730 ENOG4108ZC9 flagellar basal-body rod protein flgc EXD81_17735 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EXD81_17750 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EXD81_17760 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EXD81_17765 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EXD81_17775 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EXD81_17780 ENOG4105CMV Succinyl-CoA synthetase subunit beta EXD81_17785 ENOG4105VM1 flagellar EXD81_17795 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EXD81_17800 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EXD81_17805 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EXD81_17810 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EXD81_17825 ENOG4108BW8 UPF0109 protein EXD81_17830 ENOG4105K5M 30s ribosomal protein S16 EXD81_17840 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EXD81_17860 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EXD81_17865 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EXD81_17870 ENOG4105CHR reductase EXD81_17875 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EXD81_17880 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EXD81_17885 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EXD81_17895 ENOG4105EJQ L-serine dehydratase EXD81_17905 ENOG4105DP4 dak2 domain fusion protein ylov EXD81_17910 ENOG4108ZAA Alkaline-shock protein EXD81_17915 ENOG4105VB9 50S ribosomal protein l28 EXD81_17925 ENOG4105FJ0 thiamine EXD81_17930 ENOG4105DJV ribulose-phosphate 3-epimerase EXD81_17935 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EXD81_17940 ENOG4105D9P serine threonine protein kinase EXD81_17945 ENOG4108ZF3 Phosphatase EXD81_17950 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EXD81_17955 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EXD81_17960 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EXD81_17965 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EXD81_17975 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EXD81_17985 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EXD81_17990 ENOG4105KC4 UPF0296 protein EXD81_17995 ENOG4105DSJ YicC domain protein EXD81_18005 ENOG4105F23 Fibronectin-binding protein EXD81_18015 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EXD81_18020 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EXD81_18025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EXD81_18055 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EXD81_18075 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EXD81_18085 ENOG4105CXT aspartate transcarbamylase EXD81_18095 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EXD81_18100 ENOG4105C34 Pseudouridine synthase EXD81_18105 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EXD81_18115 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EXD81_18130 ENOG4105DBK s4 domain protein EXD81_18135 ENOG41067XK integral membrane protein EXD81_18140 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EXD81_18145 ENOG4105DFA alanine racemase domain protein EXD81_18150 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EXD81_18155 ENOG4105WR5 sporulation protein, YlmC YmxH family EXD81_18175 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EXD81_18190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EXD81_18200 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EXD81_18205 ENOG4105D4A Cell wall formation (By similarity) EXD81_18215 ENOG4105CNI cell division protein FtsW EXD81_18220 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EXD81_18225 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EXD81_18230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EXD81_18250 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EXD81_18255 ENOG4108V6E Cell division protein mraZ EXD81_18280 ENOG41067VY 50S ribosomal protein L32 EXD81_18285 ENOG4105KNH Nucleic acid-binding protein EXD81_18300 ENOG4105D78 K07001 NTE family protein EXD81_18305 ENOG4105H20 Sporulation integral membrane protein YlbJ EXD81_18315 ENOG4106H78 methyltransferase EXD81_18340 ENOG4106UY4 Inherit from COG: Scp-like extracellular EXD81_18345 ENOG41080XQ Signal transduction protein with cbs domains EXD81_18360 ENOG41064X9 cytochrome C oxidase subunit IV EXD81_18365 ENOG4105CCU oxidase (Subunit III) EXD81_18380 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EXD81_18430 ENOG4105QA2 EXD81_18435 ENOG4105CI3 gtp-binding protein typa EXD81_18460 ENOG4105D4Y metalloprotease EXD81_18470 ENOG4105ECY inositol monophosphatase EXD81_18490 ENOG4105WBI UPF0223 protein EXD81_18495 ENOG4105CXN decarboxylase EXD81_18515 ENOG4107QN2 dihydrolipoyl dehydrogenase EXD81_18520 ENOG4105C7S Dehydrogenase EXD81_18525 ENOG4105CPP Dehydrogenase, E1 component EXD81_18535 ENOG4105FQP Beta-lactamase EXD81_18545 ENOG4105C0W non-ribosomal peptide synthetase EXD81_18595 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EXD81_18600 ENOG4108X4Q Hydrolase EXD81_18605 ENOG4106148 UPF0356 protein EXD81_18610 ENOG4105CN5 Metallo-Beta-Lactamase EXD81_18615 ENOG4105CPN adenine deaminase EXD81_18620 ENOG4107ZYR domain protein EXD81_18630 ENOG4105BZU Histidine kinase EXD81_18660 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EXD81_18665 ENOG4105C5H ABC transporter EXD81_18680 ENOG4105DM4 PTS System EXD81_18690 ENOG4105E98 transcriptional regulator DeoR family EXD81_18700 ENOG4105C19 ABC transporter EXD81_18715 ENOG41067WU Molybdopterin converting factor (Subunit 1) EXD81_18720 ENOG4108ZAF Molybdopterin EXD81_18725 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EXD81_18735 ENOG4105D06 uba thif-type nad fad binding protein EXD81_18740 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EXD81_18755 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EXD81_18760 ENOG4105D8X mechanosensitive ion channel EXD81_18780 ENOG4105NQC Flavodoxin EXD81_18810 ENOG4108XRC Protein of unknown function (DUF458) EXD81_18815 ENOG4107IN1 Protein of unknown function (DUF1797) EXD81_18840 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein EXD81_18850 ENOG4105UIN EXD81_18855 ENOG4107R88 Chemotaxis protein (CheV) EXD81_18880 ENOG4105K4I Scp-like extracellular EXD81_18900 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EXD81_18905 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EXD81_18910 ENOG4105F6S Spore photoproduct lyase EXD81_18920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EXD81_18925 ENOG4105KRI phosphocarrier protein (HPr EXD81_18935 ENOG4105CID antiterminator EXD81_18945 ENOG4105DC7 peptidase M24 EXD81_18950 ENOG4105C59 p-type ATPase EXD81_18965 ENOG4105F0V Cell wall hydrolase EXD81_18990 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EXD81_19000 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EXD81_19005 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EXD81_19010 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EXD81_19015 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EXD81_19025 ENOG4108K88 Membrane EXD81_19040 ENOG4105E14 MotA TolQ exbB proton channel EXD81_19050 ENOG41090MY MarR family Transcriptional regulator EXD81_19055 ENOG4105BZU Histidine kinase EXD81_19065 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EXD81_19070 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EXD81_19075 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EXD81_19080 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EXD81_19090 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EXD81_19100 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EXD81_19105 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EXD81_19110 ENOG4105BZU Histidine kinase EXD81_19115 ENOG4108TGC Acyltransferase EXD81_19125 ENOG410900G Protein of unknown function (DUF421) EXD81_19135 ENOG4105D0M Protease HtpX homolog EXD81_19145 ENOG410681C small acid-soluble spore protein EXD81_19155 ENOG4108WZW RNA polymerase sigma EXD81_19160 ENOG4107TS3 membrane protein, TerC EXD81_19165 ENOG4107T5V SNARE associated Golgi EXD81_19170 ENOG4105FDF Could be involved in DNA repair (By similarity) EXD81_19200 ENOG4105V75 Transcriptional regulator EXD81_19205 ENOG4105CJW magnesium transporter EXD81_19225 ENOG4105VRS hydrolase family 18 EXD81_19230 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EXD81_19235 ENOG4108JJB ABC transporter EXD81_19240 ENOG4108W7F transporter, permease EXD81_19250 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EXD81_19255 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EXD81_19260 ENOG4108Y4K DNA-binding transcriptional activator EXD81_19265 ENOG4105D8G Major Facilitator superfamily EXD81_19275 ENOG4107TVC Glycosyl transferase, family 2 EXD81_19290 ENOG4108ZHJ Organic hydroperoxide resistance protein EXD81_19295 ENOG4105K56 Transcriptional regulator EXD81_19310 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EXD81_19315 ENOG4105CIY formyltetrahydrofolate deformylase EXD81_19320 ENOG41080TC multidrug resistance protein EXD81_19330 ENOG4108428 Inherit from COG: -acetyltransferase EXD81_19335 ENOG4108S4H thioesterase Superfamily protein EXD81_19340 ENOG4107TUM Amidinotransferase EXD81_19345 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EXD81_19350 ENOG4108JQ7 (ABC) transporter EXD81_19365 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EXD81_19375 ENOG4105C3U ABC transporter EXD81_19380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EXD81_19385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EXD81_19390 ENOG4108ME1 Peptidase M55 D-aminopeptidase EXD81_19400 ENOG4105C0H protease EXD81_19405 ENOG4105CKK Glycosyl transferase, family 2 EXD81_19420 ENOG4107R7I amino acid EXD81_19425 ENOG4107GRR phosphate transport regulator EXD81_19430 ENOG4105CJ3 phosphate transporter EXD81_19445 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EXD81_19485 ENOG410906S phage-like element pbsx protein xkdt EXD81_19490 ENOG41066EA baseplate J family protein EXD81_19495 ENOG4105MFU Protein of unknown function (DUF2634) EXD81_19505 ENOG4105X7F EXD81_19510 ENOG4108WZM domain protein EXD81_19525 ENOG4105MTC XkdN-like protein EXD81_19535 ENOG4105PQS phage protein EXD81_19550 ENOG41060SN EXD81_19575 ENOG4108MDF Phage Portal Protein EXD81_19580 ENOG4105IG6 Phage terminase, large subunit EXD81_19585 ENOG4108TFU terminase (Small subunit) EXD81_19625 ENOG410635T phage-like element pbsx protein EXD81_19635 ENOG4105K7W phage-related replication protein EXD81_19640 ENOG4105KWG Pfam:DUF1696 EXD81_19660 ENOG4107TSN permease EXD81_19690 ENOG4105BZU Histidine kinase EXD81_19710 ENOG4105F3H Histidine kinase EXD81_19715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EXD81_19720 ENOG4105CTX dehydratase EXD81_19725 ENOG4107QZW Altronate oxidoreductase EXD81_19730 ENOG4107KJX Transcriptional regulator EXD81_19735 ENOG4105CT4 transporter EXD81_19740 ENOG4105D2H Uronic isomerase EXD81_19755 ENOG4105Q95 Cupin 2, conserved barrel domain protein EXD81_19765 ENOG4108IXI (ABC) transporter EXD81_19770 ENOG4105C4B ABC transporter, permease EXD81_19775 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EXD81_19785 ENOG41087PP glycosyltransferase MGT family EXD81_19825 ENOG4105KT7 mgtC SapB transporter EXD81_19855 ENOG4105VCP PTS System EXD81_19870 ENOG4105CMR udp-glucose 4-epimerase EXD81_19930 ENOG4105C28 cystathionine EXD81_19935 ENOG4105C28 cystathionine EXD81_19945 ENOG4108ZMI UPF0477 protein EXD81_19980 ENOG4105ENA helicase EXD81_20035 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EXD81_20040 ENOG4105DWF phosphomethylpyrimidine kinase EXD81_20045 ENOG4105D06 uba thif-type nad fad binding protein EXD81_20065 ENOG4108VEU Thiamine monophosphate synthase EXD81_20085 ENOG4107S1Q Phosphatase EXD81_20090 ENOG4105EMS pseudouridine synthase EXD81_20115 ENOG4105E4C Lytic transglycosylase catalytic EXD81_20120 ENOG4108Z18 K06886 hemoglobin EXD81_20130 ENOG4105DPN Oligoendopeptidase f EXD81_20140 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EXD81_20145 ENOG4108ZCF integral membrane protein EXD81_20150 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EXD81_20165 ENOG4108JQ7 (ABC) transporter EXD81_20175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EXD81_20180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EXD81_20190 ENOG4105C31 Tryptophanyl-tRNA synthetase EXD81_20200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EXD81_20220 ENOG4105C3U ABC transporter EXD81_20235 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EXD81_20250 ENOG4107RMD Basic membrane lipoprotein EXD81_20280 ENOG4105DBV ornithine carbamoyltransferase EXD81_20290 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EXD81_20295 ENOG4105C8Y Acetylornithine aminotransferase EXD81_20300 ENOG4105CAS nag kinase EXD81_20310 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EXD81_20325 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EXD81_20330 ENOG4105VG1 fes assembly suf system protein EXD81_20335 ENOG4108MXZ Esterase EXD81_20340 ENOG4108KP7 hydrolase EXD81_20345 ENOG41073B9 EXD81_20355 ENOG4107AYK membrAne EXD81_20360 ENOG4105EPR degv family EXD81_20370 ENOG4107E6A Cytochrome p-450 EXD81_20375 ENOG4105C8Q Methyl-accepting chemotaxis EXD81_20385 ENOG4105QNR S1 RNA binding domain protein