locus-tag class description A1R12_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A1R12_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A1R12_00015 ENOG410848D S4 domain protein YaaA A1R12_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A1R12_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A1R12_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A1R12_00060 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) A1R12_00070 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) A1R12_00075 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) A1R12_00080 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) A1R12_00085 ENOG4105BZW Glycerate kinase A1R12_00095 ENOG4105ZMH deoxynucleoside kinase A1R12_00105 ENOG4105VRS hydrolase family 18 A1R12_00110 ENOG4105GTG Isochorismatase A1R12_00115 ENOG4108Z6B deaminase A1R12_00125 ENOG4105C6E dna polymerase iii A1R12_00130 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) A1R12_00135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) A1R12_00145 ENOG41067KS pro-sigma K processing A1R12_00175 ENOG4105CDW Resistance protein A1R12_00180 ENOG4105CXN decarboxylase A1R12_00185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) A1R12_00190 ENOG4105X0R protein from nitrogen regulatory protein P-II A1R12_00195 ENOG4105XVJ Protein of unknown function (DUF327) A1R12_00200 ENOG4105FA2 dna polymerase iii A1R12_00205 ENOG4105MA4 psp1 domain protein A1R12_00215 ENOG41060K3 Methyltransferase A1R12_00220 ENOG4105VC4 domain protein A1R12_00225 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) A1R12_00230 ENOG4105KRN Transcriptional regulator, abrb family A1R12_00235 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) A1R12_00240 ENOG4105F8V Hydrolase, tatD family A1R12_00245 ENOG41069ER domain protein A1R12_00255 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) A1R12_00260 ENOG4105XFA sporulation peptidase YabG A1R12_00265 ENOG4105W42 Veg protein A1R12_00270 ENOG4105XEW small acid-soluble spore protein A1R12_00275 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) A1R12_00280 ENOG4105DFT pur operon repressor A1R12_00285 ENOG4105KME endoribonuclease L-psp A1R12_00290 ENOG4105K4W Could be involved in septation (By similarity) A1R12_00295 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) A1R12_00300 ENOG4105C5T Phosphoribosyl pyrophosphate synthase A1R12_00305 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) A1R12_00320 ENOG4108JA2 transcriptioN-repair coupling factor A1R12_00325 ENOG4108M14 stage v sporulation protein t A1R12_00335 ENOG4108IY2 MazG family A1R12_00340 ENOG41082I2 s4 domain protein A1R12_00345 ENOG4105VYY sporulation protein yabp A1R12_00360 ENOG41060GV RNA binding s1 domain protein A1R12_00390 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) A1R12_00395 ENOG4108UGV hypoxanthine phosphoribosyltransferase A1R12_00400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) A1R12_00405 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) A1R12_00410 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) A1R12_00415 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase A1R12_00420 ENOG4105C6T cysteine synthase A1R12_00425 ENOG4105CRQ synthase (Component I) A1R12_00430 ENOG4105DDQ anthranilate synthase A1R12_00435 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 A1R12_00440 ENOG4105EEI dihydropteroate synthase A1R12_00445 ENOG4105KRF dihydroneopterin aldolase A1R12_00450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A1R12_00460 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) A1R12_00465 ENOG4105CRK lysyL-tRNA synthetase A1R12_00555 ENOG4108Z0C Uvrb UvrC protein A1R12_00560 ENOG41066A3 ATP guanido phosphotransferase A1R12_00570 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) A1R12_00575 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) A1R12_00580 ENOG4105CTP PilT protein domain protein A1R12_00585 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) A1R12_00590 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) A1R12_00595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) A1R12_00600 ENOG4105D7W serine acetyltransferase A1R12_00610 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) A1R12_00615 ENOG4105C2N RNA methyltransferase TrmH family group 3 A1R12_00620 ENOG4105M0M Tetracycline resistance protein A1R12_00640 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A1R12_00645 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) A1R12_00655 ENOG4108VZM 50s ribosomal protein L10 A1R12_00660 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) A1R12_00665 ENOG4107Y49 methyltransferase A1R12_00670 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A1R12_00675 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A1R12_00680 ENOG4105XPM ribosomal protein A1R12_00685 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) A1R12_00690 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) A1R12_00695 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) A1R12_00700 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) A1R12_00705 ENOG4107SKW Inherit from COG: Alpha beta hydrolase A1R12_00710 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) A1R12_00715 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) A1R12_00720 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) A1R12_00725 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) A1R12_00730 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity A1R12_00735 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) A1R12_00740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) A1R12_00745 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) A1R12_00750 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) A1R12_00755 ENOG41082SA 50s ribosomal protein l29 A1R12_00760 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal A1R12_00775 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits A1R12_00780 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) A1R12_00785 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) A1R12_00790 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) A1R12_00795 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) A1R12_00800 ENOG4105VPB 50S ribosomal protein L30 A1R12_00805 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) A1R12_00810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) A1R12_00815 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A1R12_00820 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) A1R12_00825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) A1R12_00835 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits A1R12_00840 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) A1R12_00845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) A1R12_00850 ENOG4108ZT0 50S ribosomal protein l17 A1R12_00855 ENOG4108JJB ABC transporter A1R12_00860 ENOG4108JJB ABC transporter A1R12_00865 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) A1R12_00870 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) A1R12_00875 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) A1R12_00880 ENOG4108UJD 30S ribosomal protein S9 A1R12_00885 ENOG4108I0C methyltransferase A1R12_00905 ENOG4105D1F ATP-binding protein A1R12_00920 ENOG4108NMV polysaccharide deacetylase A1R12_01025 ENOG4108JPW Aminotransferase A1R12_01040 ENOG4105CHH sulfate transporter A1R12_01050 ENOG4108SA1 esterase A1R12_01070 ENOG410874W AraC family transcriptional regulator A1R12_01075 ENOG4105EHZ conserved protein UCP016719 A1R12_01080 ENOG4105D17 glycoside hydrolase, family 3 domain protein A1R12_01095 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate A1R12_01105 ENOG4105EWC Purine nucleoside phosphorylase A1R12_01135 ENOG4105EMN RNA polymerase sigma factor A1R12_01145 ENOG4105C8B TIGR00159 family A1R12_01150 ENOG4107U5W ybbr family A1R12_01155 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) A1R12_01195 ENOG4106K80 A1R12_01205 ENOG41067MG lrgb family A1R12_01215 ENOG41061AU MarR family Transcriptional regulator A1R12_01230 ENOG4105BZU Histidine kinase A1R12_01235 ENOG4105WH1 Two component transcriptional regulator luxr family A1R12_01240 ENOG4105CJ1 ABC, transporter A1R12_01265 ENOG4106DDH Sporulation-specific SASP protein A1R12_01280 ENOG4107QTZ amino acid A1R12_01300 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A1R12_01305 ENOG4105CXY transporter A1R12_01340 ENOG4107SCQ Iron-containing alcohol dehydrogenase A1R12_01345 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A1R12_01350 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase A1R12_01355 ENOG4107ZTW SNARE associated Golgi A1R12_01370 ENOG4105C72 UPF0176 protein A1R12_01380 ENOG4105CM2 brancheD-chain amino acid aminotransferase A1R12_01385 ENOG4108IQI permease A1R12_01390 ENOG4108J5H Homocysteine s-methyltransferase A1R12_01400 ENOG4105CSV Glutaminase A1R12_01430 ENOG41076HS cation diffusion facilitator family transporter A1R12_01435 ENOG4108TVJ Nitroreductase A1R12_01440 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase A1R12_01445 ENOG4108VGI doxx family A1R12_01450 ENOG4105XXY Thioredoxin A1R12_01465 ENOG4105DGI Alkaline phosphatase A1R12_01470 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A1R12_01475 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A1R12_01480 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) A1R12_01485 ENOG4107EPV Aminotransferase class V A1R12_01490 ENOG4105C0R drug resistance transporter emrb qaca subfamily A1R12_01495 ENOG4105J7D transcriptional regulator A1R12_01500 ENOG4107RB3 L-asparaginase A1R12_01505 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold A1R12_01510 ENOG41060AI SEC-C motif A1R12_01515 ENOG4107SET aldo keto reductase A1R12_01545 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A1R12_01555 ENOG4105DSE periplasmic solute binding protein A1R12_01560 ENOG4105DIK (ABC) transporter A1R12_01570 ENOG4105DEN Luciferase family A1R12_01575 ENOG4108N0M stress protein A1R12_01580 ENOG4106FN3 tellurium resistance protein A1R12_01585 ENOG4106FN3 tellurium resistance protein A1R12_01590 ENOG4107TS3 membrane protein, TerC A1R12_01595 ENOG4108TTB tellurium resistance protein A1R12_01605 ENOG41079KZ Major Facilitator Superfamily A1R12_01610 ENOG4108IJ7 Glycine betaine A1R12_01615 ENOG4107SQ8 Glycine betaine A1R12_01645 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) A1R12_01675 ENOG4105EIG urea carboxylase-associated protein 1 A1R12_01680 ENOG4107RA1 nh(3)-dependent nad( ) synthetase A1R12_01685 ENOG4105DQ6 Transposase A1R12_01695 ENOG4105I1F Resistance protein A1R12_01700 ENOG4108WBH protein TIM barrel A1R12_01705 ENOG4105DJB Major Facilitator Superfamily A1R12_01710 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) A1R12_01715 ENOG4105I82 acetyl xylan esterase A1R12_01720 ENOG410756H nucleotidyltransferase A1R12_01730 ENOG4105C26 Dehydrogenase A1R12_01735 ENOG4105CK7 Sodium proline symporter A1R12_01740 ENOG4107YHD transcriptional regulator A1R12_01745 ENOG4105CAY ferredoxin--nadp reductase A1R12_01750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A1R12_01755 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit A1R12_01760 ENOG4108IFG nitrite reductase, (NAD(P)H) A1R12_01765 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) A1R12_01780 ENOG4105CKI cobalamin synthesis protein A1R12_01785 ENOG4105E2A Dehydrogenase A1R12_01790 ENOG4105HHM rdd domain containing protein A1R12_01815 ENOG41080HJ 6-phospho 3-hexuloisomerase A1R12_01820 ENOG4108VA3 3-hexulose-6-phosphate synthase A1R12_01825 ENOG4105KVH Transcriptional regulator A1R12_01835 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_01855 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) A1R12_01865 ENOG4105SX7 Transporter A1R12_01885 ENOG4105CDA abc transporter atp-binding protein A1R12_01890 ENOG4105DRP amino acid AbC transporter A1R12_01900 ENOG4106P55 Transcriptional regulator A1R12_01905 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase A1R12_01910 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) A1R12_01915 ENOG41069ZX A1R12_01920 ENOG41069ZX A1R12_01925 ENOG4105DUX Transporter A1R12_01940 ENOG4105E1K spore germination protein A1R12_01955 ENOG4105CPU Monooxygenase A1R12_01960 ENOG4108XSB acetyltransferase, (GNAT) family A1R12_01965 ENOG4105EAB amino acid AbC transporter A1R12_01970 ENOG4108HW4 amino acid AbC transporter A1R12_01980 ENOG4105CH2 amidohydrolase A1R12_01985 ENOG4108PGP mmge prpd family protein A1R12_01995 ENOG4107WD8 ABC transporter, permease A1R12_02000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A1R12_02005 ENOG4105BZU Histidine kinase A1R12_02020 ENOG4105CFH Aspartokinase A1R12_02025 ENOG4105DHS permease protein A1R12_02030 ENOG4105CM4 permease protein A1R12_02035 ENOG4108IPW abc transporter atp-binding protein A1R12_02050 ENOG4105R8C Transcriptional regulator A1R12_02055 ENOG4108DBC nitroreductase A1R12_02060 ENOG41067V3 Antibiotic biosynthesis monooxygenase A1R12_02065 ENOG4105YVS arsR family transcriptional regulator A1R12_02075 ENOG4108JPW Aminotransferase A1R12_02080 ENOG4105C26 Dehydrogenase A1R12_02090 ENOG4105H9W Short-chain dehydrogenase reductase Sdr A1R12_02095 ENOG4105KTB nuclear export factor GLE1 A1R12_02100 ENOG4108T5E Copper resistance protein A1R12_02105 ENOG4108ZYE Transcriptional regulator A1R12_02125 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase A1R12_02140 ENOG4105E7W lamb ycsf family protein A1R12_02145 ENOG4105C5A transporter A1R12_02150 ENOG4105CFM UPF0317 protein A1R12_02155 ENOG4105P4J Allophanate hydrolase, subunit 1 A1R12_02165 ENOG4107258 Transcriptional regulator A1R12_02170 ENOG4105XJB lipolytic protein G-D-S-L family A1R12_02180 ENOG41061CK Antibiotic biosynthesis monooxygenase A1R12_02185 ENOG4107RVG penicillin-binding protein A1R12_02190 ENOG4107QM2 Aldo Keto reductase A1R12_02195 ENOG4105ETD TRANSCRIPTIONal A1R12_02205 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A1R12_02220 ENOG410606W general stress protein A1R12_02230 ENOG4105VCH membrane A1R12_02240 ENOG4105C9U ATP-dependent DNA helicase RecQ A1R12_02255 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) A1R12_02260 ENOG4107R8N Glycosyl transferase, family 2 A1R12_02270 ENOG4105C0X amino acid A1R12_02330 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) A1R12_02340 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) A1R12_02345 ENOG4105RXJ A1R12_02350 ENOG4105KPY Small multidrug resistance protein A1R12_02355 ENOG4105EU9 A1R12_02360 ENOG4105QVS general stress protein A1R12_02365 ENOG41082W1 Cupin 2, conserved barrel domain protein A1R12_02380 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit A1R12_02385 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism A1R12_02390 ENOG4108MRH transcriptional regulatory protein A1R12_02395 ENOG4107QJT sodium dicarboxylate symporter A1R12_02400 ENOG4106F5Q Membrane A1R12_02405 ENOG4105CJ1 ABC, transporter A1R12_02420 ENOG4105FDT acyl-CoA dehydrogenase A1R12_02435 ENOG4105SZ6 Thioredoxin A1R12_02440 ENOG4105CPF Cell wall formation (By similarity) A1R12_02445 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) A1R12_02450 ENOG4105C1J atp-dependent rna helicase A1R12_02455 ENOG410905X membrane-flanked domain protein A1R12_02460 ENOG4105CKV Membrane A1R12_02470 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) A1R12_02475 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein A1R12_02480 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A1R12_02490 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) A1R12_02495 ENOG4107MMM Anti-sigma-factor antagonist A1R12_02500 ENOG4105FUA antagonist A1R12_02505 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase A1R12_02510 ENOG4107SGM protein serine threonine phosphatase A1R12_02515 ENOG4105WN5 stage II sporulation protein A1R12_02520 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) A1R12_02530 ENOG41064BQ Phosphatase A1R12_02540 ENOG410906U SprT-like A1R12_02580 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A1R12_02590 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein A1R12_02610 ENOG4105CSH Transporter A1R12_02635 ENOG4108Z40 Transcriptional regulator A1R12_02640 ENOG4108RYK Nad-dependent epimerase dehydratase A1R12_02645 ENOG4105VEQ Cold shock protein A1R12_02650 ENOG4108VJ1 Transcriptional regulator (CarD family A1R12_02670 ENOG4105IRW patatin-like phospholipase family protein A1R12_02680 ENOG41082W1 Cupin 2, conserved barrel domain protein A1R12_02695 ENOG4105DNP FAD linked oxidase domain protein A1R12_02705 ENOG4105PGM cation diffusion facilitator family transporter A1R12_02710 ENOG4105H3G oxidoreductase A1R12_02720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A1R12_02755 ENOG4105DWF phosphomethylpyrimidine kinase A1R12_02770 ENOG4105DQ4 alcohol dehydrogenase A1R12_02775 ENOG4105VUF Transcriptional regulator A1R12_02785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A1R12_02800 ENOG4105EQ0 Major Facilitator superfamily A1R12_02805 ENOG4108JGH Tetr family transcriptional regulator A1R12_02810 ENOG4105T38 integral membrane protein A1R12_02815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A1R12_02830 ENOG4105E2A Dehydrogenase A1R12_02835 ENOG4105PGS Spore coat protein A1R12_02850 ENOG4105ENE Histidine kinase A1R12_02855 ENOG4108VB1 regulatoR A1R12_02860 ENOG4105EYF MMPL domain protein A1R12_02880 ENOG4108JYZ YitT family A1R12_02890 ENOG4105C2C drug resistance transporter, Bcr CflA A1R12_02895 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A1R12_02915 ENOG41090E6 transcriptional regulator MERR family A1R12_02925 ENOG4105F2W methyltransferase A1R12_02930 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A1R12_02935 ENOG4105DRR Transcriptional regulator, GntR family A1R12_02955 ENOG4105FQP Beta-lactamase A1R12_02960 ENOG41090UD (LipO)protein A1R12_02965 ENOG4108SUT Major Facilitator Superfamily A1R12_02970 ENOG4108TZY GntR Family Transcriptional Regulator A1R12_02975 ENOG4105JXH GntR family transcriptional regulator A1R12_02980 ENOG4105DJ2 Major Facilitator Superfamily A1R12_03000 ENOG4107QTZ amino acid A1R12_03020 ENOG4107QNK )-transporter A1R12_03055 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) A1R12_03060 ENOG4105K8N protein family UPF0079, ATPase A1R12_03065 ENOG41072GX Peptidase M22 Glycoprotease A1R12_03070 ENOG410801F ribosomal-protein-alanine acetyltransferase A1R12_03075 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A1R12_03080 ENOG4105C5H ABC transporter A1R12_03085 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A1R12_03090 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) A1R12_03095 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) A1R12_03100 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) A1R12_03110 ENOG4108TYN CAAX amino terminal protease family protein A1R12_03115 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) A1R12_03120 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) A1R12_03130 ENOG4105PGZ NB-ARC domain A1R12_03135 ENOG4105CPQ Dehydrogenase A1R12_03140 ENOG4105CT4 transporter A1R12_03155 ENOG41087YS Phage shock protein A A1R12_03160 ENOG4105DQX Zinc finger domain A1R12_03165 ENOG4108WV1 Pfam:DUF477 A1R12_03175 ENOG4105EXC Acyl-transferase A1R12_03180 ENOG4108P49 AntiSigma factor A1R12_03185 ENOG4105JVQ RNA Polymerase A1R12_03210 ENOG4107STQ Multicopper oxidase A1R12_03215 ENOG4105C85 amino acid A1R12_03225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 A1R12_03240 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) A1R12_03260 ENOG4105C7N Xanthine uracil vitamin C permease A1R12_03285 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) A1R12_03290 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit A1R12_03295 ENOG4105C83 adenylosuccinate lyase A1R12_03300 ENOG4105C8V SAICAR synthetase A1R12_03305 ENOG4105VR9 phosphoribosylformylglycinamidine synthase A1R12_03310 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I A1R12_03315 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii A1R12_03325 ENOG4105CXB phosphoribosylaminoimidazole synthetase A1R12_03330 ENOG4108V3E phosphoribosylglycinamide formyltransferase A1R12_03335 ENOG4105DC1 bifunctional purine biosynthesis protein purh A1R12_03340 ENOG4105C12 Phosphoribosylglycinamide synthetase A1R12_03355 ENOG4108R5T secreted protein A1R12_03360 ENOG4105KGF protein, YerC YecD A1R12_03365 ENOG4105CBC glutamate synthase A1R12_03380 ENOG4105C4R Atp-dependent dna helicase A1R12_03385 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) A1R12_03395 ENOG4105CRN Aminoglycoside phosphotransferase A1R12_03400 ENOG4105KT7 mgtC SapB transporter A1R12_03405 ENOG4105CK7 Sodium proline symporter A1R12_03410 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A1R12_03415 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) A1R12_03420 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) A1R12_03425 ENOG4108IG5 Transcriptional regulator A1R12_03435 ENOG4105CBD Diacylglycerol kinase A1R12_03440 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A1R12_03450 ENOG4105CJ1 ABC, transporter A1R12_03475 ENOG4105CDY transcriptional regulatory protein A1R12_03495 ENOG4105WEF catalase A1R12_03500 ENOG4105M18 -acetyltransferase A1R12_03510 ENOG4105H67 Protein of unknown function (DUF421) A1R12_03515 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) A1R12_03520 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily A1R12_03535 ENOG4106I4J membrane A1R12_03545 ENOG41082F9 transcriptional regulator A1R12_03550 ENOG41061H0 Monooxygenase A1R12_03555 ENOG4108R1P A1R12_03560 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A1R12_03575 ENOG4105CJ1 ABC, transporter A1R12_03585 ENOG4105E0M Sulfatase A1R12_03590 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase A1R12_03600 ENOG41090R9 glycosyltransferase A1R12_03605 ENOG4107R51 Glycosyl transferase, family 2 A1R12_03610 ENOG41090R9 glycosyltransferase A1R12_03615 ENOG4105EU0 Major facilitator Superfamily A1R12_03620 ENOG4105CUB amino acid A1R12_03625 ENOG4105C26 Dehydrogenase A1R12_03630 ENOG4105FKZ Methyl-accepting chemotaxis A1R12_03635 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A1R12_03640 ENOG4107TVC Glycosyl transferase, family 2 A1R12_03645 ENOG4105C5H ABC transporter A1R12_03650 ENOG4107SWG transcriptional regulator MERR family A1R12_03655 ENOG4105DXB Major Facilitator superfamily A1R12_03660 ENOG4105C5H ABC transporter A1R12_03665 ENOG4105FDU atp-dependent rna helicase A1R12_03675 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein A1R12_03690 ENOG4108J20 pectate lyase A1R12_03695 ENOG4107QPK )-transporter A1R12_03720 ENOG4108VAC response regulator A1R12_03730 ENOG4108Z6X (sortase) family A1R12_03740 ENOG4108MRH transcriptional regulatory protein A1R12_03765 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) A1R12_03770 ENOG4108RPX mosc domain containing protein A1R12_03780 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) A1R12_03820 ENOG4105C5Y PTS System A1R12_03825 ENOG4105CG3 alpha amylase, catalytic region A1R12_03830 ENOG4107414 GntR family transcriptional regulator A1R12_03835 ENOG4108RCM Nitroreductase A1R12_03850 ENOG4105CGH 5'-nucleotidase A1R12_03855 ENOG4107RKG DJ-1/PfpI family A1R12_03860 ENOG4105ETE Transcriptional regulator (LacI family A1R12_03865 ENOG4105E2X shikimate dehydrogenase A1R12_03870 ENOG4105FF2 Type I DHQase A1R12_03885 ENOG4105KJF protein tyrosine phosphatase A1R12_03895 ENOG4107U9T Pfam:Ribonuclease_BN A1R12_03900 ENOG4108ISG Major Facilitator A1R12_03905 ENOG4105UPD Calcium Proton A1R12_03915 ENOG4105D8X mechanosensitive ion channel A1R12_03935 ENOG4106KE4 Dehydrogenase A1R12_03945 ENOG4105D7N magnesium and cobalt transport protein CorA A1R12_03955 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) A1R12_03975 ENOG4107RUY (E1 component), alpha subunit A1R12_03985 ENOG4107QKR Dehydrogenase A1R12_03995 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family A1R12_04005 ENOG4105F8D glycoside hydrolase family 4 A1R12_04010 ENOG4108Q3X Transcriptional regulator A1R12_04015 ENOG4105CI1 PTS System A1R12_04020 ENOG4105BZ1 (ABC) transporter A1R12_04025 ENOG4105BZ1 (ABC) transporter A1R12_04035 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase A1R12_04045 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A1R12_04050 ENOG4105U3E Transcriptional regulator A1R12_04055 ENOG4105DYS nad(p)h dehydrogenase (quinone) A1R12_04060 ENOG4105H93 Acyltransferase family A1R12_04075 ENOG4108YYS metal-dependent hydrolase (By similarity) A1R12_04080 ENOG4105C0R drug resistance transporter emrb qaca subfamily A1R12_04085 ENOG410834F Transcriptional regulator A1R12_04095 ENOG4105JAB phenazine biosynthesis protein, phzf family A1R12_04100 ENOG4107Y03 Nitroreductase A1R12_04110 ENOG4105ECP epimerase A1R12_04115 ENOG410902V Modulates RecA activity (By similarity) A1R12_04125 ENOG4105F27 Major Facilitator A1R12_04135 ENOG4108TCS Glutamyl endopeptidase A1R12_04155 ENOG4106AKJ A1R12_04160 ENOG4105D74 hydrolase A1R12_04165 ENOG4105CKK Glycosyl transferase, family 2 A1R12_04170 ENOG4105EJV Membrane A1R12_04175 ENOG41067AE Membrane-bound metal-dependent hydrolase A1R12_04180 ENOG4105CEN a g-specific adenine glycosylase A1R12_04185 ENOG4106BXE A1R12_04190 ENOG4105CAN Short-chain dehydrogenase reductase Sdr A1R12_04210 ENOG4105BZ1 (ABC) transporter A1R12_04215 ENOG4107NBY Membrane A1R12_04220 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A1R12_04225 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A1R12_04230 ENOG4105G5W regulator Fur family A1R12_04235 ENOG4105TUA UPF0295 protein A1R12_04335 ENOG4107S6Z Na H antiporter A1R12_04340 ENOG4105EC3 peptidase S51, dipeptidase E A1R12_04345 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) A1R12_04350 ENOG4105DNP FAD linked oxidase domain protein A1R12_04360 ENOG4105DEF Extracellular solute-binding protein, family 5 A1R12_04370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A1R12_04375 ENOG4105C3U ABC transporter A1R12_04380 ENOG4108JQ7 (ABC) transporter A1R12_04395 ENOG4105E2Y ABC, transporter A1R12_04400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein A1R12_04405 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component A1R12_04415 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) A1R12_04420 ENOG4107D63 A1R12_04425 ENOG4105VZ8 Transcriptional regulator A1R12_04440 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) A1R12_04450 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) A1R12_04470 ENOG4105CYN Serine protein kinase A1R12_04480 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes A1R12_04485 ENOG4105CW7 secretion protein, HlyD family A1R12_04490 ENOG4105C0R drug resistance transporter emrb qaca subfamily A1R12_04495 ENOG4105CS1 NAD(P)H quinone oxidoreductase A1R12_04510 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family A1R12_04515 ENOG4105CZV ABC transporter A1R12_04520 ENOG4105CJ1 ABC, transporter A1R12_04525 ENOG4108TU7 Inherit from COG: (ABC) transporter A1R12_04530 ENOG4105VEQ Cold shock protein A1R12_04540 ENOG4105BZU Histidine kinase A1R12_04580 ENOG4108YBP pseudouridine synthase A1R12_04590 ENOG41080XP Cbs domain A1R12_04595 ENOG4107YBY Hydrolase A1R12_04600 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A1R12_04605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A1R12_04610 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator A1R12_04620 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) A1R12_04625 ENOG4105C6V Glycerol-3-phosphate dehydrogenase A1R12_04635 ENOG4105BZU Histidine kinase A1R12_04640 ENOG4105WH1 Two component transcriptional regulator luxr family A1R12_04675 ENOG4105ED1 spovr family A1R12_04680 ENOG4105G6Z alkaline phosphatase A1R12_04695 ENOG4105BZN citrate synthase A1R12_04700 ENOG4105CYX Short-chain dehydrogenase reductase Sdr A1R12_04705 ENOG4105CUB amino acid A1R12_04710 ENOG4105C8J )-transporter A1R12_04720 ENOG4105J37 A1R12_04725 ENOG4108AEY RNA polymerase sigma factor A1R12_04730 ENOG4105F6E Acyl-transferase A1R12_04735 ENOG4105C37 (CBS) domain A1R12_04745 ENOG4105CHM Aminotransferase A1R12_04750 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase A1R12_04755 ENOG4105C37 (CBS) domain A1R12_04765 ENOG4105WMR Protein CrcB homolog A1R12_04770 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A1R12_04775 ENOG4105D64 Mechanosensitive ion channel A1R12_04780 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) A1R12_04785 ENOG4107VMI polysaccharide deacetylase A1R12_04790 ENOG4105F0I Aminotransferase A1R12_04795 ENOG4105W1N transcriptional regulator A1R12_04800 ENOG4105IIP Membrane A1R12_04810 ENOG4105BZ1 (ABC) transporter A1R12_04815 ENOG4105BZ1 (ABC) transporter A1R12_04835 ENOG410839P A1R12_04845 ENOG4106MP8 UPF0754 membrane protein A1R12_04850 ENOG4105WZB UPF0342 protein A1R12_04855 ENOG4105F1N DNA alkylation repair A1R12_04865 ENOG4105D4P Coproporphyrinogen iii oxidase A1R12_04875 ENOG4107S91 Sodium hydrogen exchanger A1R12_04880 ENOG4105NCW Trka-c domain protein A1R12_04890 ENOG4105CGU Enoyl-CoA hydratase A1R12_04900 ENOG4108IUX (ABC) transporter A1R12_04905 ENOG4105RHA ABC transporter, permease A1R12_04910 ENOG4107VRP DNA repair exonuclease A1R12_04915 ENOG4106D4I domain protein A1R12_04920 ENOG4105EQI Metal Dependent Phosphohydrolase A1R12_04930 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) A1R12_04970 ENOG4105NBU tryptophan transport protein A1R12_04975 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) A1R12_04980 ENOG4105K59 histidine triad (HIT) protein A1R12_05010 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation A1R12_05015 ENOG4105BZ4 penicillin-binding protein A1R12_05020 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) A1R12_05025 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) A1R12_05030 ENOG4105C1Q protoporphyrinogen oxidase A1R12_05040 ENOG4105ECB domain protein A1R12_05055 ENOG4105DER m42 family A1R12_05065 ENOG4108RQ5 Beta-lactamase domain-containing protein A1R12_05070 ENOG4105DF9 Lipoate-protein, ligase A1R12_05080 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_05090 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 A1R12_05105 ENOG4108HUF Transporter A1R12_05110 ENOG4107TB6 phosphoglycerate mutase A1R12_05120 ENOG4107F3J Amp-dependent synthetase and ligase A1R12_05125 ENOG4107ZYJ bioY protein A1R12_05130 ENOG4106YBV Methyl-accepting chemotaxis A1R12_05150 ENOG4105XVF Competence transcription factor A1R12_05160 ENOG4108ZMX Domain of unknown function (DU1801) A1R12_05175 ENOG4105X3H Excalibur domain protein A1R12_05180 ENOG4105K8R UPF0145 protein A1R12_05185 ENOG4105E1V na solute symporter A1R12_05190 ENOG4106CAD Protein of unknown function (DUF3311) A1R12_05195 ENOG41060YP A1R12_05210 ENOG4107SCK Monooxygenase A1R12_05215 ENOG4108INS Transcriptional regulator A1R12_05220 ENOG4108KK1 membrane protein AbrB duplication A1R12_05230 ENOG4108IG5 Transcriptional regulator A1R12_05245 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination A1R12_05250 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation A1R12_05260 ENOG4105EYH Exonuclease A1R12_05305 ENOG4105ERH Fumarylacetoacetate hydrolase A1R12_05325 ENOG4105CAQ asparagine synthetase A1R12_05335 ENOG4105UQX Mate efflux family protein A1R12_05340 ENOG4106HBX Transcriptional Regulator AraC Family A1R12_05345 ENOG4105SF0 DinB family A1R12_05350 ENOG4108ZUB Lysine exporter protein (Lyse ygga) A1R12_05355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A1R12_05360 ENOG4105MYW Pentapeptide repeat protein A1R12_05365 ENOG4105MA6 gCN5-related N-acetyltransferase A1R12_05375 ENOG4108VPT UPF0234 protein A1R12_05380 ENOG4105QNR S1 RNA binding domain protein A1R12_05385 ENOG4105DIH basic membrane A1R12_05390 ENOG4105C8Q Methyl-accepting chemotaxis A1R12_05395 ENOG4107E6A Cytochrome p-450 A1R12_05400 ENOG4105EPR degv family A1R12_05405 ENOG4107AYK membrAne A1R12_05415 ENOG41073B9 A1R12_05420 ENOG4108KP7 hydrolase A1R12_05425 ENOG4108MXZ Esterase A1R12_05430 ENOG4105VG1 fes assembly suf system protein A1R12_05435 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) A1R12_05440 ENOG4105IQ5 FAD linked oxidase domain protein A1R12_05450 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase A1R12_05460 ENOG4105CAS nag kinase A1R12_05465 ENOG4105C8Y Acetylornithine aminotransferase A1R12_05470 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A1R12_05480 ENOG4105DBV ornithine carbamoyltransferase A1R12_05510 ENOG4107RMD Basic membrane lipoprotein A1R12_05525 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) A1R12_05530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) A1R12_05540 ENOG4105C3U ABC transporter A1R12_05545 ENOG4108JQ7 (ABC) transporter A1R12_05560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A1R12_05570 ENOG4105C31 Tryptophanyl-tRNA synthetase A1R12_05575 ENOG4108J59 Extracellular solute-binding protein, family 5 A1R12_05580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A1R12_05585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A1R12_05595 ENOG4108JQ7 (ABC) transporter A1R12_05610 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) A1R12_05615 ENOG4108ZCF integral membrane protein A1R12_05620 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis A1R12_05630 ENOG4105DPN Oligoendopeptidase f A1R12_05635 ENOG4105T58 Dithiol-disulfide isomerase A1R12_05640 ENOG4108Z18 K06886 hemoglobin A1R12_05645 ENOG4105E4C Lytic transglycosylase catalytic A1R12_05650 ENOG4105MIX Adenylate cyclase A1R12_05665 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A1R12_05670 ENOG4105EMS pseudouridine synthase A1R12_05675 ENOG4107S1Q Phosphatase A1R12_05685 ENOG4105ETU transcriptional activator (TenA A1R12_05690 ENOG4108VEU Thiamine monophosphate synthase A1R12_05710 ENOG4105D06 uba thif-type nad fad binding protein A1R12_05715 ENOG4105DWF phosphomethylpyrimidine kinase A1R12_05720 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH A1R12_05725 ENOG4107A88 A1R12_05775 ENOG4105ENA helicase A1R12_05795 ENOG4105CJ1 ABC, transporter A1R12_05810 ENOG4108ZMI UPF0477 protein A1R12_05820 ENOG4105C28 cystathionine A1R12_05825 ENOG4105C28 cystathionine A1R12_05895 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A1R12_05905 ENOG4106BHF A1R12_05930 ENOG410907G A1R12_05965 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase A1R12_05970 ENOG4105CMR udp-glucose 4-epimerase A1R12_05975 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) A1R12_05980 ENOG4105CK1 PTS System A1R12_05985 ENOG4105VCP PTS System A1R12_06020 ENOG4105KT7 mgtC SapB transporter A1R12_06040 ENOG4108IEG Formate dehydrogenase Alpha subunit A1R12_06050 ENOG4106A3M Cytochrome p-450 A1R12_06055 ENOG41087PP glycosyltransferase MGT family A1R12_06065 ENOG4105EXQ uroporphyrinogen iii synthase hem4 A1R12_06070 ENOG4105C4B ABC transporter, permease A1R12_06075 ENOG4108IXI (ABC) transporter A1R12_06085 ENOG4105Q95 Cupin 2, conserved barrel domain protein A1R12_06100 ENOG4105D2H Uronic isomerase A1R12_06105 ENOG4105CT4 transporter A1R12_06110 ENOG4107KJX Transcriptional regulator A1R12_06115 ENOG4107QZW Altronate oxidoreductase A1R12_06120 ENOG4105CTX dehydratase A1R12_06125 ENOG4107TSN permease A1R12_06140 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase A1R12_06145 ENOG4105KWG Pfam:DUF1696 A1R12_06150 ENOG4105K7W phage-related replication protein A1R12_06155 ENOG4105WEF catalase A1R12_06160 ENOG410635T phage-like element pbsx protein A1R12_06200 ENOG4108TFU terminase (Small subunit) A1R12_06205 ENOG4105IG6 Phage terminase, large subunit A1R12_06210 ENOG4108MDF Phage Portal Protein A1R12_06235 ENOG41060SN A1R12_06250 ENOG4105PQS phage protein A1R12_06255 ENOG4105FR7 XkdM protein, phage-like element PBSX A1R12_06260 ENOG4105MTC XkdN-like protein A1R12_06265 ENOG4108FKH Transglycosylase SLT domain A1R12_06265 ENOG4108FKH Transglycosylase SLT domain A1R12_06265 ENOG4108FKH Transglycosylase SLT domain A1R12_06270 ENOG4108WZM domain protein A1R12_06275 ENOG4105X7F A1R12_06285 ENOG4105MFU Protein of unknown function (DUF2634) A1R12_06290 ENOG41066EA baseplate J family protein A1R12_06295 ENOG410906S phage-like element pbsx protein xkdt A1R12_06305 ENOG41068G1 A1R12_06335 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A1R12_06350 ENOG4105CJ3 phosphate transporter A1R12_06355 ENOG4107GRR phosphate transport regulator A1R12_06360 ENOG4107R7I amino acid A1R12_06370 ENOG4105EDW glycosyl transferase, family 39 A1R12_06375 ENOG4105CKK Glycosyl transferase, family 2 A1R12_06380 ENOG4105C0H protease A1R12_06390 ENOG4108ME1 Peptidase M55 D-aminopeptidase A1R12_06395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component A1R12_06400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component A1R12_06405 ENOG4105C3U ABC transporter A1R12_06415 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A A1R12_06420 ENOG4105DTQ mandelate racemase muconate lactonizing A1R12_06425 ENOG4107SN7 NLP P60 protein A1R12_06430 ENOG4108JQ7 (ABC) transporter A1R12_06435 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) A1R12_06440 ENOG4107TUM Amidinotransferase A1R12_06445 ENOG4108S4H thioesterase Superfamily protein A1R12_06450 ENOG4108428 Inherit from COG: -acetyltransferase A1R12_06460 ENOG41080TC multidrug resistance protein A1R12_06465 ENOG4105CIY formyltetrahydrofolate deformylase A1R12_06470 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A1R12_06485 ENOG4105K56 Transcriptional regulator A1R12_06490 ENOG4108ZHJ Organic hydroperoxide resistance protein A1R12_06505 ENOG4107TVC Glycosyl transferase, family 2 A1R12_06515 ENOG4105D8G Major Facilitator superfamily A1R12_06520 ENOG4108Y4K DNA-binding transcriptional activator A1R12_06525 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) A1R12_06530 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A1R12_06540 ENOG4108W7F transporter, permease A1R12_06545 ENOG4108JJB ABC transporter A1R12_06550 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein A1R12_06555 ENOG4105VRS hydrolase family 18 A1R12_06560 ENOG4105CJW magnesium transporter A1R12_06565 ENOG4105V75 Transcriptional regulator A1R12_06585 ENOG4105DQE DNA ligase A1R12_06590 ENOG4105FDF Could be involved in DNA repair (By similarity) A1R12_06595 ENOG4107T5V SNARE associated Golgi A1R12_06600 ENOG4107TS3 membrane protein, TerC A1R12_06605 ENOG4108WZW RNA polymerase sigma A1R12_06615 ENOG410681C small acid-soluble spore protein A1R12_06625 ENOG4105D0M Protease HtpX homolog A1R12_06635 ENOG410900G Protein of unknown function (DUF421) A1R12_06640 ENOG4108TGC Acyltransferase A1R12_06645 ENOG4105BZU Histidine kinase A1R12_06650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A1R12_06655 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) A1R12_06665 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase A1R12_06675 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate A1R12_06680 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) A1R12_06685 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) A1R12_06690 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) A1R12_06700 ENOG4105BZU Histidine kinase A1R12_06705 ENOG41090MY MarR family Transcriptional regulator A1R12_06710 ENOG4105ER2 Ompa motb domain protein A1R12_06715 ENOG4105E14 MotA TolQ exbB proton channel A1R12_06725 ENOG4108K88 Membrane A1R12_06735 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) A1R12_06740 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase A1R12_06745 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) A1R12_06750 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) A1R12_06760 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr A1R12_06785 ENOG4105F0V Cell wall hydrolase A1R12_06800 ENOG4105C59 p-type ATPase A1R12_06805 ENOG4105DC7 peptidase M24 A1R12_06815 ENOG4105CID antiterminator A1R12_06825 ENOG4105KRI phosphocarrier protein (HPr A1R12_06830 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) A1R12_06840 ENOG4105F6S Spore photoproduct lyase A1R12_06845 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer A1R12_06850 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase A1R12_06855 ENOG4105K4I Scp-like extracellular A1R12_06865 ENOG4105BZU Histidine kinase A1R12_06870 ENOG4105CHM Aminotransferase A1R12_06875 ENOG4107R88 Chemotaxis protein (CheV) A1R12_06880 ENOG4105UIN A1R12_06890 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein A1R12_06900 ENOG4105K6S Short-chain dehydrogenase reductase Sdr A1R12_06910 ENOG4105EPM Diguanylate phosphodiesterase A1R12_06915 ENOG4107IN1 Protein of unknown function (DUF1797) A1R12_06920 ENOG4108XRC Protein of unknown function (DUF458) A1R12_06950 ENOG4105NQC Flavodoxin A1R12_06970 ENOG4105D8X mechanosensitive ion channel A1R12_06975 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A1R12_06990 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) A1R12_06995 ENOG4105D06 uba thif-type nad fad binding protein A1R12_07000 ENOG4105CVM Molybdenum cofactor synthesis domain protein A1R12_07005 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein A1R12_07010 ENOG4108ZAF Molybdopterin A1R12_07015 ENOG41067WU Molybdopterin converting factor (Subunit 1) A1R12_07025 ENOG4107X8C Efflux transporter RND family MFP subunit A1R12_07030 ENOG4105C19 ABC transporter A1R12_07035 ENOG4107RBB ABC transporter, permease A1R12_07040 ENOG4105E98 transcriptional regulator DeoR family A1R12_07045 ENOG4105DE4 1-phosphofructokinase A1R12_07050 ENOG4105DM4 PTS System A1R12_07065 ENOG4105C5H ABC transporter A1R12_07070 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) A1R12_07095 ENOG4105BZU Histidine kinase A1R12_07105 ENOG4107ZYR domain protein A1R12_07110 ENOG4105CPN adenine deaminase A1R12_07115 ENOG4105CN5 Metallo-Beta-Lactamase A1R12_07120 ENOG4106148 UPF0356 protein A1R12_07125 ENOG4108X4Q Hydrolase A1R12_07130 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A1R12_07150 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A1R12_07155 ENOG4105C0W non-ribosomal peptide synthetase A1R12_07160 ENOG4107SQU synthase A1R12_07165 ENOG4105C0W non-ribosomal peptide synthetase A1R12_07170 ENOG4107SQU synthase A1R12_07175 ENOG4107SQU synthase A1R12_07180 ENOG4107SQU synthase A1R12_07185 ENOG4105C0W non-ribosomal peptide synthetase A1R12_07190 ENOG4105FQP Beta-lactamase A1R12_07200 ENOG4105CPP Dehydrogenase, E1 component A1R12_07205 ENOG4105C7S Dehydrogenase A1R12_07210 ENOG4107QN2 dihydrolipoyl dehydrogenase A1R12_07225 ENOG4105CXN decarboxylase A1R12_07230 ENOG4105WBI UPF0223 protein A1R12_07245 ENOG4105ECY inositol monophosphatase A1R12_07255 ENOG4105D4Y metalloprotease A1R12_07290 ENOG4105CI3 gtp-binding protein typa A1R12_07295 ENOG4105QA2 A1R12_07310 ENOG4108IAB Phoh family A1R12_07320 ENOG4105CSV Glutaminase A1R12_07330 ENOG4105CNI cell division protein FtsW A1R12_07335 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) A1R12_07345 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) A1R12_07355 ENOG4105BZ9 Cytochrome C oxidase, subunit I A1R12_07360 ENOG4105CCU oxidase (Subunit III) A1R12_07365 ENOG41064X9 cytochrome C oxidase subunit IV A1R12_07380 ENOG41080XQ Signal transduction protein with cbs domains A1R12_07385 ENOG4106UY4 Inherit from COG: Scp-like extracellular A1R12_07410 ENOG4106H78 methyltransferase A1R12_07415 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) A1R12_07420 ENOG4105H20 Sporulation integral membrane protein YlbJ A1R12_07425 ENOG4105D78 K07001 NTE family protein A1R12_07430 ENOG41063PX domain protein A1R12_07435 ENOG4105CDE UPF0348 protein A1R12_07440 ENOG4105KNH Nucleic acid-binding protein A1R12_07465 ENOG4108V6E Cell division protein mraZ A1R12_07470 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) A1R12_07480 ENOG4105CJN penicillin-binding protein A1R12_07485 ENOG4105CJN penicillin-binding protein A1R12_07490 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) A1R12_07495 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) A1R12_07500 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) A1R12_07505 ENOG4105CNI cell division protein FtsW A1R12_07510 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) A1R12_07515 ENOG4105D4A Cell wall formation (By similarity) A1R12_07520 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) A1R12_07525 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) A1R12_07530 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) A1R12_07540 ENOG4105FFI sigma-e processing peptidase spoiiga A1R12_07545 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_07555 ENOG4105DKW ABC transporter A1R12_07565 ENOG4105WR5 sporulation protein, YlmC YmxH family A1R12_07570 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase A1R12_07575 ENOG4105DFA alanine racemase domain protein A1R12_07580 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) A1R12_07585 ENOG41067XK integral membrane protein A1R12_07590 ENOG4105DBK s4 domain protein A1R12_07605 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) A1R12_07615 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) A1R12_07620 ENOG4105C34 Pseudouridine synthase A1R12_07625 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) A1R12_07635 ENOG4105CXT aspartate transcarbamylase A1R12_07645 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain A1R12_07650 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain A1R12_07655 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) A1R12_07660 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) A1R12_07665 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) A1R12_07670 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) A1R12_07685 ENOG4107RIQ Sulfate adenylate transferase A1R12_07695 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) A1R12_07700 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein A1R12_07705 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein A1R12_07710 ENOG4105F23 Fibronectin-binding protein A1R12_07720 ENOG4105DSJ YicC domain protein A1R12_07725 ENOG4105KC4 UPF0296 protein A1R12_07730 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) A1R12_07740 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase A1R12_07745 ENOG4105C25 Primosomal protein n' A1R12_07750 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) A1R12_07755 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) A1R12_07760 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B A1R12_07765 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs A1R12_07770 ENOG4108ZF3 Phosphatase A1R12_07775 ENOG4105D9P serine threonine protein kinase A1R12_07780 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) A1R12_07785 ENOG4105DJV ribulose-phosphate 3-epimerase A1R12_07790 ENOG4105FJ0 thiamine A1R12_07800 ENOG4105VB9 50S ribosomal protein l28 A1R12_07805 ENOG4108ZAA Alkaline-shock protein A1R12_07810 ENOG4105DP4 dak2 domain fusion protein ylov A1R12_07820 ENOG4105EJQ L-serine dehydratase A1R12_07825 ENOG4105CB5 ATP-dependent DNA helicase recG A1R12_07830 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) A1R12_07835 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) A1R12_07840 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A1R12_07845 ENOG4105CHR reductase A1R12_07850 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) A1R12_07855 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) A1R12_07860 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) A1R12_07865 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) A1R12_07875 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) A1R12_07885 ENOG4105K5M 30s ribosomal protein S16 A1R12_07890 ENOG4108BW8 UPF0109 protein A1R12_07905 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) A1R12_07910 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) A1R12_07915 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) A1R12_07920 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A1R12_07930 ENOG4105VM1 flagellar A1R12_07935 ENOG4105CMV Succinyl-CoA synthetase subunit beta A1R12_07940 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha A1R12_07945 ENOG4105C79 DNA protecting protein DprA A1R12_07950 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) A1R12_07955 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) A1R12_07960 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A1R12_07965 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) A1R12_07970 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) A1R12_07980 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) A1R12_07985 ENOG4108ZC9 flagellar basal-body rod protein flgc A1R12_07990 ENOG4105VQ0 flagellar hook-basal body complex protein fliE A1R12_07995 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) A1R12_08000 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A1R12_08015 ENOG4106YF4 Flagellar biosynthesis chaperone A1R12_08025 ENOG410696Y Flagellar hook-length control protein A1R12_08030 ENOG410822I Flagellar hook capping protein A1R12_08035 ENOG4108JQA flagellar A1R12_08040 ENOG41068WV flagellar FlbD family protein A1R12_08050 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) A1R12_08055 ENOG4105DD5 Flagellar motor switch protein A1R12_08060 ENOG4107YTP response regulator receiver protein A1R12_08070 ENOG4105CN7 Flagellar biosynthetic protein FliP A1R12_08075 ENOG4105VS8 Flagellar biosynthetic protein fliq A1R12_08080 ENOG4105D19 Role in flagellar biosynthesis (By similarity) A1R12_08085 ENOG4105D00 flagellar biosynthetic protein flhB A1R12_08090 ENOG4105D7B Flagellar biosynthesis protein flha A1R12_08095 ENOG4105FZW flagellar biosynthesis regulator FlhF A1R12_08105 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) A1R12_08110 ENOG4105CBS Chea signal transduction histidine kinase A1R12_08115 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis A1R12_08125 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) A1R12_08130 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_08140 ENOG4105CE9 30S ribosomal protein S2 A1R12_08150 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) A1R12_08155 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) A1R12_08160 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) A1R12_08165 ENOG4105KNE Phosphatidate cytidylyltransferase A1R12_08175 ENOG4105DZP Membrane-associated zinc metalloprotease A1R12_08180 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) A1R12_08185 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) A1R12_08190 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) A1R12_08195 ENOG4105CHV Transcription elongation factor NusA A1R12_08200 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination A1R12_08205 ENOG4105VHM ribosomal protein A1R12_08210 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) A1R12_08215 ENOG4105W7A Protein of unknown function (DUF503) A1R12_08220 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) A1R12_08225 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) A1R12_08230 ENOG4105DTN riboflavin biosynthesis protein ribF A1R12_08235 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) A1R12_08240 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) A1R12_08250 ENOG4105C1V Peptidase, M16 A1R12_08260 ENOG4105E35 Dipicolinate synthase subunit A A1R12_08265 ENOG4108S0H Dipicolinic acid synthetase, b subunit A1R12_08270 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) A1R12_08280 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) A1R12_08290 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit A1R12_08300 ENOG4105CNU cell division protein FtsK A1R12_08305 ENOG4105FDP GntR family transcriptional regulator A1R12_08320 ENOG4105EYF MMPL domain protein A1R12_08335 ENOG4108RKS Short-chain dehydrogenase reductase Sdr A1R12_08340 ENOG4105XZV Protein of unknown function (DUF3243) A1R12_08355 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase A1R12_08360 ENOG4105CEV competence damage-inducible protein A1R12_08365 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) A1R12_08370 ENOG4108A04 Beta-lactamase A1R12_08380 ENOG4105D48 metallophosphoesterase A1R12_08385 ENOG4105MCT stage V sporulation protein S A1R12_08390 ENOG4105CPQ Dehydrogenase A1R12_08395 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A1R12_08400 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A1R12_08420 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) A1R12_08445 ENOG4105DQ6 Transposase A1R12_08460 ENOG4108151 Beta-lactamase domain protein A1R12_08465 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A1R12_08470 ENOG4108JA1 polyketide synthase A1R12_08475 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase A1R12_08480 ENOG41062T2 Acyl carrier protein A1R12_08485 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase A1R12_08490 ENOG4108MGH Enoyl-CoA hydratase A1R12_08495 ENOG4108KQ6 Enoyl-CoA hydratase A1R12_08500 ENOG4105C0W non-ribosomal peptide synthetase A1R12_08505 ENOG4107SQU synthase A1R12_08515 ENOG4105C0W non-ribosomal peptide synthetase A1R12_08525 ENOG4106A3M Cytochrome p-450 A1R12_08530 ENOG4105WFK nuclease A1R12_08535 ENOG4105XPP Protein of unknown function (DUF1275) A1R12_08545 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin A1R12_08555 ENOG4105K7W phage-related replication protein A1R12_08560 ENOG4108X3M OsmC Ohr family protein A1R12_08585 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) A1R12_08610 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A1R12_08615 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) A1R12_08620 ENOG4105U6W MutT NUDIX family protein A1R12_08625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A1R12_08635 ENOG4106F1P AAA ATPase, central domain protein A1R12_08640 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) A1R12_08645 ENOG4105CXI aluminum resistance protein A1R12_08650 ENOG4105KV4 Transcriptional regulator A1R12_08655 ENOG4105C5F glutamine synthetase A1R12_08680 ENOG4105CT4 transporter A1R12_08685 ENOG4105DSG hydrolase family 43 A1R12_08695 ENOG4105C93 Xylose Isomerase A1R12_08700 ENOG4105CMG Carbohydrate kinase A1R12_08705 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) A1R12_08725 ENOG4105DQ4 alcohol dehydrogenase A1R12_08735 ENOG4105EPI acetyltransferase, (GNAT) family A1R12_08755 ENOG4108M1A Chitin-binding protein A1R12_08760 ENOG41068WN A1R12_08775 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) A1R12_08780 ENOG4105K7W phage-related replication protein A1R12_08800 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) A1R12_08810 ENOG4108SVB resolvase A1R12_08815 ENOG4105VPS UPF0291 protein A1R12_08820 ENOG4105CV1 Transketolase (EC 2.2.1.1) A1R12_08830 ENOG4105VXM UPF0154 protein A1R12_08840 ENOG4107QIV Cytochrome c biogenesis protein A1R12_08875 ENOG4108I0Z Aconitate hydratase A1R12_08880 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen A1R12_08895 ENOG41067CD Small, acid-soluble spore protein Tlp A1R12_08905 ENOG4105MI2 A1R12_08910 ENOG4105W8X HesB YadR YfhF-family protein A1R12_08915 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) A1R12_08920 ENOG4105K4P CoA-binding domain protein A1R12_08925 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A1R12_08950 ENOG4105CPQ Dehydrogenase A1R12_08955 ENOG4108UHU Aldolase A1R12_08960 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) A1R12_08965 ENOG4105DMW Dehydrogenase reductase A1R12_08975 ENOG4108I5G Major Facilitator superfamily A1R12_08990 ENOG4105FVX A1R12_09035 ENOG4107R39 (ABC) transporter A1R12_09070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A1R12_09080 ENOG4107SYN Glycosyl hydrolases family 43 A1R12_09110 ENOG4105DTD Dehydrogenase A1R12_09115 ENOG4108IIH CoA-transferase subunit B A1R12_09120 ENOG4105D6N CoA-transferase, subunit a A1R12_09125 ENOG4105CY2 Citrate transporter A1R12_09130 ENOG4106A3M Cytochrome p-450 A1R12_09135 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) A1R12_09140 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) A1R12_09145 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) A1R12_09150 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A1R12_09155 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) A1R12_09165 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A1R12_09170 ENOG4107T5V SNARE associated Golgi A1R12_09175 ENOG4107QX3 carboxylase A1R12_09180 ENOG4105E39 Enoyl-CoA hydratase A1R12_09185 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase A1R12_09190 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit A1R12_09195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A1R12_09200 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_09205 ENOG4105C1G acyl-Coa dehydrogenase A1R12_09210 ENOG4105F32 YngK protein A1R12_09215 ENOG4106U2H Protein of unknown function (DUF1360) A1R12_09225 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_09230 ENOG4105C0W non-ribosomal peptide synthetase A1R12_09240 ENOG4105C0W non-ribosomal peptide synthetase A1R12_09245 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family A1R12_09250 ENOG4108N2V aldose 1-epimerase A1R12_09255 ENOG4107QJQ Mate efflux family protein A1R12_09280 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A1R12_09285 ENOG4108RWP Major Facilitator Superfamily protein A1R12_09290 ENOG4105WAB arsR family transcriptional regulator A1R12_09295 ENOG4105C22 threonyL-tRNA synthetase A1R12_09300 ENOG4108KSA LysR family transcriptional regulator A1R12_09305 ENOG4105CB2 alcohol dehydrogenase A1R12_09310 ENOG4105BZ8 glutamate synthase A1R12_09315 ENOG4105CBC glutamate synthase A1R12_09320 ENOG4105C5Q Transcriptional regulator A1R12_09325 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) A1R12_09350 ENOG4108UB7 A1R12_09355 ENOG4105IE8 Alpha-ketoglutarate permease A1R12_09360 ENOG4107U6E carbohydrate kinase FGGY A1R12_09365 ENOG4108M3J Dehydrogenase A1R12_09370 ENOG4108J2R molybdopterin oxidoreductase A1R12_09395 ENOG4106ANW SMI1_KNR4 A1R12_09400 ENOG4106BHF A1R12_09405 ENOG4108Z7R Chaperone CsaA A1R12_09410 ENOG4105FTV AraC Family Transcriptional Regulator A1R12_09420 ENOG4108W8B Beta-lactamase domain protein A1R12_09430 ENOG4105KTU Transcriptional regulator, arsr family A1R12_09440 ENOG4108SJC Membrane A1R12_09465 ENOG41069ER domain protein A1R12_09470 ENOG4105C9U ATP-dependent DNA helicase RecQ A1R12_09480 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A1R12_09485 ENOG4105SCY DNAK suppressor A1R12_09525 ENOG4105C26 Dehydrogenase A1R12_09530 ENOG4105EWU Squalene--hopene cyclase A1R12_09535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A1R12_09540 ENOG4105C8J )-transporter A1R12_09545 ENOG4105C09 Bile acid A1R12_09555 ENOG4105C7S Dehydrogenase A1R12_09560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 A1R12_09565 ENOG4107T89 von Willebrand factor, type A A1R12_09570 ENOG4105GMT ATPase associated with various cellular activities aaa_5 A1R12_09580 ENOG4105K4H Nlp p60 protein A1R12_09585 ENOG41087PP glycosyltransferase MGT family A1R12_09595 ENOG4107QMU Mate efflux family protein A1R12_09600 ENOG4106SCS STAS domain A1R12_09620 ENOG4105FR1 rard protein A1R12_09635 ENOG41090U3 tautomerase A1R12_09655 ENOG4105FBA Phospholipase Carboxylesterase A1R12_09670 ENOG4105E1V na solute symporter A1R12_09680 ENOG4105CS2 ec 3.2.1.21 A1R12_09685 ENOG4108S3Y transcriptional regulator A1R12_09705 ENOG4108VXD carboxy-peptidase A1R12_09710 ENOG4105D3A purine nucleoside phosphorylase DeoD-type A1R12_09715 ENOG4106Z5R A1R12_09720 ENOG410841Q phosphoesterase PA-phosphatase related protein A1R12_09745 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein A1R12_09750 ENOG4108TSC N-acetyltransferase A1R12_09755 ENOG4107S4Y M20 DapE family protein YgeY A1R12_09770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) A1R12_09775 ENOG4105FTQ Dna gyrase A1R12_09835 ENOG410780I phosphoprotein phosphatase activity A1R12_09860 ENOG4106ANW SMI1_KNR4 A1R12_09865 ENOG4106BHF A1R12_09875 ENOG4107Y9E nuclease A1R12_09890 ENOG4105E0X reductase A1R12_09895 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) A1R12_09905 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) A1R12_09910 ENOG41090WU lipolytic protein G-D-S-L family A1R12_09915 ENOG4108KF3 Electron transport protein SCO1 SenC A1R12_09925 ENOG4105C7B Threonine dehydratase A1R12_09935 ENOG4108UT2 hemolysin iii A1R12_09945 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) A1R12_09950 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) A1R12_09960 ENOG4107YX5 Pfam:DUF548 A1R12_09965 ENOG4108Y6J UPF0403 protein A1R12_09970 ENOG4105C01 Dihydroxy-acid dehydratase A1R12_09985 ENOG4108V06 Glutathione peroxidase A1R12_09990 ENOG4105CVG Homoserine O-transsuccinylase A1R12_10030 ENOG41081VK Ribonuclease A1R12_10050 ENOG410890F Dynamin family A1R12_10060 ENOG41065KQ synthase A1R12_10120 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase A1R12_10140 ENOG41068G1 A1R12_10150 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj A1R12_10160 ENOG4108FKH Transglycosylase SLT domain A1R12_10270 ENOG4105QBX endodeoxyribonuclease RusA A1R12_10320 ENOG4108ZUE Phage regulatory protein rha A1R12_10330 ENOG41067QW Transcriptional regulator A1R12_10335 ENOG4105VTR Integrase A1R12_10340 ENOG4105C2W permease A1R12_10345 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) A1R12_10350 ENOG4105CTD carboxy-peptidase A1R12_10355 ENOG4105DVT helicase A1R12_10365 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) A1R12_10375 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) A1R12_10380 ENOG4108UKS UPF0398 protein A1R12_10385 ENOG4107X2U Inherit from COG: Exonuclease-like protein A1R12_10390 ENOG4108I5C dEAD DEAH box helicase A1R12_10435 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) A1R12_10440 ENOG4105BZ4 penicillin-binding protein A1R12_10450 ENOG4105DQ6 Transposase A1R12_10460 ENOG4105CSM endonuclease III A1R12_10470 ENOG4105C5S asparaginyl-tRNA synthetase A1R12_10475 ENOG4105CHM Aminotransferase A1R12_10485 ENOG4105DVT helicase A1R12_10490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) A1R12_10500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) A1R12_10510 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate A1R12_10515 ENOG4105CPK Glycosyl transferase (Group 1 A1R12_10520 ENOG4105FJR Lmbe family A1R12_10525 ENOG4108Z5K methylglyoxal synthase A1R12_10530 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) A1R12_10535 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase A1R12_10540 ENOG4108JYZ YitT family A1R12_10545 ENOG4105F0F Oxalate decarboxylase A1R12_10565 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) A1R12_10585 ENOG41068YB TPR repeat-containing protein A1R12_10590 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase A1R12_10600 ENOG4105CIH Imidazole acetol-phosphate transaminase A1R12_10610 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) A1R12_10615 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase A1R12_10620 ENOG4105DK0 Indole-3-glycerol phosphate synthase A1R12_10630 ENOG4105CRQ synthase (Component I) A1R12_10635 ENOG4105KHN chorismate mutase A1R12_10645 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase A1R12_10650 ENOG4105BZU Histidine kinase A1R12_10655 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) A1R12_10660 ENOG4105EAH synthase A1R12_10665 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A1R12_10670 ENOG4105XXQ heptaprenyl diphosphate synthase component I A1R12_10675 ENOG4105WP2 Tryptophan RNA-binding attenuator protein A1R12_10680 ENOG4105EUJ GTP cyclohydrolase i A1R12_10685 ENOG4105K70 DNA-binding protein A1R12_10690 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) A1R12_10705 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase A1R12_10710 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) A1R12_10725 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) A1R12_10730 ENOG4105CAT Cytidine monophosphate kinase A1R12_10740 ENOG4105MSI germination protein ypeb A1R12_10750 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) A1R12_10755 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase A1R12_10770 ENOG4107RGJ metallophosphoesterase A1R12_10785 ENOG4105I7S Abortive infection protein A1R12_10790 ENOG4105C9U ATP-dependent DNA helicase RecQ A1R12_10795 ENOG4105T7X A1R12_10805 ENOG4108SAX Membrane A1R12_10810 ENOG4108JQ1 Dehydrogenase A1R12_10825 ENOG4105BZU Histidine kinase A1R12_10830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A1R12_10835 ENOG4105CRE cytochrome C A1R12_10840 ENOG4107TWT Cytochrome c biogenesis protein A1R12_10850 ENOG4105FE9 pseudouridine synthase A1R12_10860 ENOG4108JIC nucleoside recognition domain protein A1R12_10865 ENOG4105DZ1 carboxypeptidase A1R12_10875 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) A1R12_10880 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) A1R12_10895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) A1R12_10900 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) A1R12_10905 ENOG4108R6K riboflavin synthase, subunit alpha A1R12_10930 ENOG4107ZE5 PPIases accelerate the folding of proteins A1R12_10935 ENOG4105PTM secreted protein A1R12_10940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) A1R12_10950 ENOG4105G6R Stage v sporulation protein ae A1R12_10960 ENOG4105CZ3 stage V sporulation protein ad A1R12_10965 ENOG41090VF Stage v sporulation protein ac A1R12_10980 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_10985 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) A1R12_10990 ENOG41082AN stage II sporulation protein A1R12_10995 ENOG4105DZ1 carboxypeptidase A1R12_11000 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) A1R12_11005 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) A1R12_11010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) A1R12_11020 ENOG4105I3K Ferric uptake regulator, Fur family A1R12_11025 ENOG4105MZ9 stage II sporulation protein m A1R12_11045 ENOG4105DFD Na H antiporter A1R12_11050 ENOG4108IJ0 Aspartate ammonia-lyase A1R12_11055 ENOG4105HDK L-asparaginase A1R12_11060 ENOG4108IMY Transcriptional regulator A1R12_11070 ENOG4108YZ4 nudix hydrolase A1R12_11080 ENOG4105CPC Aldo Keto reductase A1R12_11100 ENOG4106HZJ A1R12_11105 ENOG4105RHY Pfam:UPF0157 A1R12_11110 ENOG4105KAC Antibiotic biosynthesis monooxygenase A1R12_11115 ENOG4108XET gCN5-related N-acetyltransferase A1R12_11120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A1R12_11135 ENOG4105C02 permease A1R12_11140 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase A1R12_11145 ENOG4105CS9 pantothenic acid kinase A1R12_11155 ENOG4108IXY short-chain dehydrogenase reductase A1R12_11160 ENOG41069FQ Metallo-beta-lactamase superfamily A1R12_11165 ENOG4105II7 pyrroline-5-carboxylate reductase A1R12_11170 ENOG4108KQ6 Enoyl-CoA hydratase A1R12_11175 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase A1R12_11180 ENOG4106A3M Cytochrome p-450 A1R12_11195 ENOG4105C0W non-ribosomal peptide synthetase A1R12_11200 ENOG4105C0W non-ribosomal peptide synthetase A1R12_11215 ENOG4105C0W non-ribosomal peptide synthetase A1R12_11225 ENOG4105CHR reductase A1R12_11230 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_11245 ENOG4107QKG PfaD family A1R12_11250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) A1R12_11260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A1R12_11270 ENOG410861F 50S ribosomal protein L33 A1R12_11275 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) A1R12_11280 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase A1R12_11285 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) A1R12_11290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) A1R12_11300 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) A1R12_11305 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A1R12_11310 ENOG4108HNZ carboxyl transferase A1R12_11315 ENOG4108ZVT methylmalonyl-coA epimerase A1R12_11320 ENOG4108VZI ErfK ybiS ycfS ynhG family protein A1R12_11325 ENOG4108QEG Membrane A1R12_11330 ENOG4105CDA abc transporter atp-binding protein A1R12_11335 ENOG4105E5Q amino acid AbC transporter A1R12_11340 ENOG4108HW3 (ABC) transporter A1R12_11345 ENOG4108Y6J UPF0403 protein A1R12_11350 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) A1R12_11355 ENOG4105C7S Dehydrogenase A1R12_11360 ENOG4105CPP Dehydrogenase, E1 component A1R12_11375 ENOG4105CKM Branched-chain carboxylic acid kinase A1R12_11380 ENOG4107RDP Dehydrogenase A1R12_11390 ENOG4108JUB Transcriptional regulator A1R12_11395 ENOG4106CCJ Protein of unknown function (DUF2627) A1R12_11400 ENOG4105CR4 methylisocitrate lyase A1R12_11405 ENOG4105DXD 2-methylcitrate dehydratase A1R12_11415 ENOG4105C1G acyl-Coa dehydrogenase A1R12_11420 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase A1R12_11430 ENOG4108QXE glycerophosphoryl diester phosphodiesterase A1R12_11435 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A1R12_11460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase A1R12_11475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) A1R12_11480 ENOG4107QQR Sporulation A1R12_11485 ENOG4105S1Z Stage IV sporulation protein B A1R12_11490 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) A1R12_11495 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) A1R12_11500 ENOG4105DX0 Hemolysin A A1R12_11505 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) A1R12_11510 ENOG4105CTB Polyprenyl synthetase A1R12_11515 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A1R12_11520 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) A1R12_11525 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) A1R12_11530 ENOG4105M7K Involved in the transcription termination process (By similarity) A1R12_11535 ENOG4108ZSR alkaline shock protein A1R12_11540 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase A1R12_11560 ENOG410644B Stage III sporulation protein af A1R12_11570 ENOG4105KQ4 Stage iii sporulation protein ad A1R12_11575 ENOG4108CQH stage III sporulation protein AC A1R12_11580 ENOG4105KR5 Stage iii sporulation protein A1R12_11585 ENOG4105CD2 stage iii sporulation protein aa A1R12_11595 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) A1R12_11600 ENOG4105DC7 peptidase M24 A1R12_11610 ENOG4105CBJ Metal-dependent enzyme A1R12_11630 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) A1R12_11635 ENOG4105WZW rhodanese family A1R12_11640 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor A1R12_11650 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) A1R12_11655 ENOG4105C0D helicase A1R12_11670 ENOG4108IMY Transcriptional regulator A1R12_11680 ENOG4105VFR signal peptidase A1R12_11740 ENOG4105C37 (CBS) domain A1R12_11765 ENOG4105C5X domain protein A1R12_11800 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase A1R12_11810 ENOG41068DG YceG-like family A1R12_11815 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A1R12_11820 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) A1R12_11825 ENOG4105E2Z phosphate ABC transporter (Permease A1R12_11830 ENOG4105C8U phosphate abc transporter A1R12_11835 ENOG4105CVA phosphate A1R12_11845 ENOG4107RF6 penicillin-binding protein A1R12_11855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) A1R12_11860 ENOG4105SXS Protein of unknown function (DUF456) A1R12_11875 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) A1R12_11880 ENOG41063Y9 A1R12_11885 ENOG4108U5J '-nucleotidase A1R12_11890 ENOG4105N80 Ferric uptake regulator, Fur family A1R12_11895 ENOG4108JYZ YitT family A1R12_11900 ENOG41069ZM Protein of unknown function (DUF2624) A1R12_11905 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) A1R12_11920 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) A1R12_11925 ENOG4105EGD dinuclear metal center protein, YbgI family A1R12_11940 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_11945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) A1R12_11950 ENOG4108UPT UPF0178 protein A1R12_11955 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) A1R12_11965 ENOG4105C38 Glycyl-tRNA synthetase beta subunit A1R12_11970 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit A1R12_11975 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) A1R12_11980 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) A1R12_11985 ENOG4105KG3 cytidine deaminase A1R12_11990 ENOG4107YR5 Diacylglycerol kinase A1R12_11995 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) A1R12_12000 ENOG4105CTJ Metal Dependent Phosphohydrolase A1R12_12005 ENOG4105C9A Phoh family A1R12_12010 ENOG4105EI1 sporulation protein yqfd A1R12_12015 ENOG41068P3 sporulation protein YqfC A1R12_12025 ENOG4105DI5 UPF0365 protein A1R12_12030 ENOG4105F7J membrane-bound serine protease A1R12_12035 ENOG4105KTH gatB Yqey A1R12_12050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) A1R12_12055 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) A1R12_12060 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) A1R12_12065 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) A1R12_12070 ENOG4105CFG Acts as a chaperone (By similarity) A1R12_12075 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ A1R12_12080 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) A1R12_12085 ENOG4105CSA Coproporphyrinogen iii oxidase A1R12_12090 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) A1R12_12100 ENOG4108ZRV stage ii sporulation protein p A1R12_12105 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) A1R12_12110 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) A1R12_12115 ENOG4105TQK DNA polymerase iii, delta' subunit A1R12_12120 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 A1R12_12125 ENOG4108UK2 deaminase A1R12_12130 ENOG4105KQC Competence protein A1R12_12140 ENOG4108D32 Methyltransferase A1R12_12150 ENOG4108WF2 Metal Dependent Phosphohydrolase A1R12_12155 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) A1R12_12160 ENOG410812S Rna-binding protein A1R12_12165 ENOG4105E2X shikimate dehydrogenase A1R12_12170 ENOG4105CQW ribosome biogenesis GTPase YqeH A1R12_12175 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase A1R12_12195 ENOG41080BT SNARE associated Golgi A1R12_12210 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_12260 ENOG4108SWU Histidine kinase A1R12_12265 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A1R12_12270 ENOG4105DHF Membrane A1R12_12275 ENOG4108UYN gCN5-related N-acetyltransferase A1R12_12280 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) A1R12_12290 ENOG4108J8C transporter major facilitator family protein A1R12_12305 ENOG4108U7W acetyltransferase A1R12_12320 ENOG4105DQF Hydrolase A1R12_12325 ENOG4108HCJ Hydrolase A1R12_12335 ENOG4105DG6 mannose-6-phosphate isomerase A1R12_12340 ENOG4105DM4 PTS System A1R12_12355 ENOG4108Z66 YbaK ebsC protein A1R12_12360 ENOG4107RSM transcriptional regulator A1R12_12365 ENOG4105D94 Major Facilitator Superfamily A1R12_12370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A1R12_12375 ENOG41082JN Transcriptional regulator A1R12_12390 ENOG4105TMB Formate nitrite transporter A1R12_12395 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) A1R12_12400 ENOG4108JB9 formate dehydrogenase A1R12_12415 ENOG4105C28 cystathionine A1R12_12445 ENOG4107XRG penicillin-binding protein A1R12_12450 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) A1R12_12460 ENOG4105CFP Peptidase U32 A1R12_12465 ENOG4105XYU peptidase (U32 family) A1R12_12470 ENOG4108VQJ O-methyltransferase A1R12_12475 ENOG4105HHA aminodeoxychorismate lyase A1R12_12485 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) A1R12_12490 ENOG4105VBH UPF0297 protein A1R12_12495 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) A1R12_12500 ENOG4105C02 permease A1R12_12505 ENOG4105CDA abc transporter atp-binding protein A1R12_12510 ENOG4105CT1 (ABC) transporter A1R12_12515 ENOG4105EAD ABC transporter A1R12_12520 ENOG4105DRP amino acid AbC transporter A1R12_12525 ENOG41060CR A1R12_12535 ENOG4105C7H Helicase, RecD TraA family A1R12_12545 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) A1R12_12550 ENOG4105C3J Cysteine desulfurase A1R12_12560 ENOG4105D1H recombination factor protein RarA A1R12_12565 ENOG4105CUZ uba thif-type nad fad binding protein A1R12_12575 ENOG4105C9M aspartyl-trna synthetase A1R12_12580 ENOG4105CUT histidyl-tRNA synthetase A1R12_12585 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A1R12_12590 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) A1R12_12595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) A1R12_12605 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) A1R12_12610 ENOG41067VP Protein of unknown function (DUF1049) A1R12_12615 ENOG4105NCW Trka-c domain protein A1R12_12620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) A1R12_12630 ENOG4105CKP Polysaccharide Biosynthesis Protein A1R12_12635 ENOG4108QG2 Membrane A1R12_12640 ENOG4105NAP A1R12_12645 ENOG4105VIE preprotein translocase, subunit YajC A1R12_12650 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) A1R12_12655 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) A1R12_12660 ENOG41061AI Protein of unknown function (DUF2905) A1R12_12665 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) A1R12_12670 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) A1R12_12690 ENOG4106678 morphogenetic protein associated with SpoVID A1R12_12695 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) A1R12_12700 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase A1R12_12705 ENOG4108IYU L-aspartate oxidase A1R12_12720 ENOG4105CQC Prephenate dehydratase A1R12_12730 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control A1R12_12740 ENOG4105K46 50S ribosomal protein l27 A1R12_12745 ENOG4105X36 (ribosomal) protein A1R12_12750 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) A1R12_12765 ENOG4107QMS site-determining protein A1R12_12770 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) A1R12_12775 ENOG4105YHC Rod shape-determining protein MreD A1R12_12780 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) A1R12_12785 ENOG4105DFF Rod shape-determining protein mreb A1R12_12790 ENOG4105W5Q DNA repair protein (RadC A1R12_12795 ENOG4108Z03 MAF-like protein A1R12_12805 ENOG4106A3R peptidase A1R12_12810 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase A1R12_12815 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) A1R12_12825 ENOG4106AR7 Spore coat protein A1R12_12830 ENOG41068KH stage VI sporulation protein D A1R12_12835 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase A1R12_12840 ENOG4105D52 delta-aminolevulinic acid dehydratase A1R12_12850 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) A1R12_12860 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) A1R12_12870 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) A1R12_12875 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) A1R12_12880 ENOG4108IUQ atp-dependent protease A1R12_12885 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) A1R12_12890 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation A1R12_12900 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A1R12_12905 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) A1R12_12910 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) A1R12_12920 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase A1R12_12925 ENOG4108ZP8 Acetolactate synthase small subunit A1R12_12930 ENOG4105C7K acetolactate synthase A1R12_12960 ENOG4107SCJ type I restriction enzyme EcoKI subunit R A1R12_12980 ENOG4105M59 Phosphodiesterase, mj0936 family A1R12_12985 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) A1R12_12990 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) A1R12_12995 ENOG4108XJQ germination protein A1R12_13000 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) A1R12_13005 ENOG41067TZ transcriptional regulator, MarR family A1R12_13010 ENOG4105PFC Transcriptional regulator A1R12_13020 ENOG4105E33 succinate dehydrogenase A1R12_13030 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit A1R12_13040 ENOG4105CFH Aspartokinase A1R12_13045 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) A1R12_13050 ENOG4105K63 Thioredoxin A1R12_13055 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) A1R12_13060 ENOG4105C10 Electron transfer flavoprotein A1R12_13065 ENOG4105BZJ Electron transfer flavoprotein A1R12_13070 ENOG41060WC Enoyl-CoA hydratase A1R12_13075 ENOG4107Z3H Transcriptional regulator, TetR family A1R12_13080 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_13085 ENOG4108YV3 Protein of unknown function (DUF2711) A1R12_13095 ENOG4105C98 muts2 protein A1R12_13100 ENOG4105DCG PHP domain protein A1R12_13115 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) A1R12_13120 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) A1R12_13125 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) A1R12_13130 ENOG4108RWN rrna methyltransferase A1R12_13135 ENOG41067MF small acid-soluble spore protein A1R12_13145 ENOG4105CQB FAD linked oxidase domain protein A1R12_13150 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A1R12_13160 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) A1R12_13165 ENOG4105DRS transport system, permease A1R12_13180 ENOG4108MDK Dehydrogenase A1R12_13190 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase A1R12_13195 ENOG4105EF1 ribulokinase A1R12_13205 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase A1R12_13210 ENOG4105CN9 Peptidase m42 family protein A1R12_13220 ENOG410696E Membrane A1R12_13225 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) A1R12_13230 ENOG4105VJV 50s ribosomal protein L35 A1R12_13235 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) A1R12_13240 ENOG41067MG lrgb family A1R12_13250 ENOG4105DY9 regulatoR A1R12_13255 ENOG4108HRK Histidine kinase A1R12_13260 ENOG4105U0R haloacid dehalogenase-like hydrolase A1R12_13265 ENOG4105C22 threonyL-tRNA synthetase A1R12_13270 ENOG4108TDW sporulation protein YtxC A1R12_13295 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) A1R12_13300 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A1R12_13305 ENOG4105KVH Transcriptional regulator A1R12_13310 ENOG4105F27 Major Facilitator A1R12_13315 ENOG4105CV8 reductase A1R12_13320 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) A1R12_13330 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) A1R12_13335 ENOG4105C2M dna polymerase I A1R12_13340 ENOG4105BZU Histidine kinase A1R12_13345 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A1R12_13355 ENOG4108HMX isocitrate dehydrogenase (NADP) A1R12_13360 ENOG4105BZN citrate synthase A1R12_13365 ENOG4105G7B Protein of unknown function (DUF2992) A1R12_13375 ENOG4108REF Sporulation integral membrane protein ytvi A1R12_13380 ENOG4105FS0 cytoplasmic membrane protein A1R12_13385 ENOG4105CA9 Pyruvate kinase A1R12_13390 ENOG4105CTQ phosphohexokinase A1R12_13395 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) A1R12_13400 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) A1R12_13410 ENOG4105C6K Malic enzyme A1R12_13415 ENOG4105C0B DNA polymerase III (alpha subunit) A1R12_13420 ENOG4105VV2 A1R12_13430 ENOG4106EVM A1R12_13435 ENOG4105SFS phosphoesterase RecJ domain protein A1R12_13450 ENOG4105E8R UPF0173 metal-dependent hydrolase A1R12_13460 ENOG4105CH7 arginosuccinase A1R12_13465 ENOG4105CDH Citrulline--aspartate ligase A1R12_13470 ENOG4105EPU Molybdenum cofactor synthesis domain protein A1R12_13475 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) A1R12_13485 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) A1R12_13490 ENOG4105KBJ sporulation protein ytfj A1R12_13500 ENOG4105VK3 rdd domain containing protein A1R12_13505 ENOG4105D07 Signal peptide peptidase, SppA A1R12_13510 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) A1R12_13515 ENOG4105EFZ amidohydrolase A1R12_13520 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) A1R12_13530 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) A1R12_13555 ENOG4105U5Y Transcriptional regulator A1R12_13565 ENOG4105BZU Histidine kinase A1R12_13570 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) A1R12_13575 ENOG4105C26 Dehydrogenase A1R12_13585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A1R12_13595 ENOG4108Z0Z intracellular protease Pfpi family A1R12_13615 ENOG4108NGU Transcriptional regulator A1R12_13630 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) A1R12_13640 ENOG4105F1V Acetoin utilization protein A1R12_13645 ENOG4105W87 Cbs domain A1R12_13650 ENOG4105DGU Histone deacetylase A1R12_13655 ENOG4105ER2 Ompa motb domain protein A1R12_13660 ENOG4107R0U MotA TolQ exbB proton channel A1R12_13665 ENOG4105ETE Transcriptional regulator (LacI family A1R12_13670 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase A1R12_13690 ENOG4105DFU Cell wall formation (By similarity) A1R12_13700 ENOG4108VDD TRNA binding domain protein A1R12_13715 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ A1R12_13730 ENOG4105C6K Malic enzyme A1R12_13735 ENOG4105C8F Beta-lactamase domain protein A1R12_13740 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) A1R12_13750 ENOG4108V15 phosphotransferase enzyme family A1R12_13765 ENOG4107F58 2'-5' rna ligase A1R12_13770 ENOG4105C6T cysteine synthase A1R12_13775 ENOG4107QSE Dipeptidase A1R12_13780 ENOG4105C7N Xanthine uracil vitamin C permease A1R12_13795 ENOG4105YW5 deoR family transcriptional regulator A1R12_13810 ENOG4105CBX hi0933 family A1R12_13815 ENOG4105C94 Transporter A1R12_13835 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component A1R12_13840 ENOG4105I1K ABC transporter A1R12_13855 ENOG41085GJ domain protein A1R12_13860 ENOG4105C8T Leucyl-tRNA synthetase A1R12_13870 ENOG4105BZU Histidine kinase A1R12_13875 ENOG410605W Major Facilitator A1R12_13890 ENOG4105C19 ABC transporter A1R12_13895 ENOG4105EWM Histidine kinase A1R12_13905 ENOG4107R34 abc transporter permease protein A1R12_13910 ENOG4105C19 ABC transporter A1R12_13930 ENOG4105DVE abc transporter atp-binding protein A1R12_13935 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family A1R12_13955 ENOG4105N5T Radical SAM Protein A1R12_13970 ENOG4107VXM glycerophosphoryl diester phosphodiesterase A1R12_13980 ENOG4105E8V Alpha Beta Hydrolase Fold protein A1R12_13985 ENOG4108Z0R Transferase A1R12_13990 ENOG4105C85 amino acid A1R12_13995 ENOG4105CAQ asparagine synthetase A1R12_14000 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP A1R12_14005 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase A1R12_14020 ENOG4105D2X ABC transporter substrate-binding protein A1R12_14030 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component A1R12_14045 ENOG4108RMU ferritin dps family protein A1R12_14060 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) A1R12_14065 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) A1R12_14070 ENOG4108V2W Carbonate dehydratase A1R12_14075 ENOG4105NRA 50s ribosomal protein l31 type b A1R12_14100 ENOG4105DTQ mandelate racemase muconate lactonizing A1R12_14105 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_14110 ENOG4108IPT Naphthoate synthase A1R12_14115 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) A1R12_14120 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) A1R12_14125 ENOG4105E4F Isochorismate synthase A1R12_14270 ENOG4105N67 Proton-coupled thiamine transporter YuaJ A1R12_14275 ENOG4105DZ6 Band 7 protein A1R12_14285 ENOG4106DF1 A1R12_14290 ENOG4108VNY MOSC domain protein A1R12_14295 ENOG4108JB8 alcohol dehydrogenase A1R12_14300 ENOG4105C26 Dehydrogenase A1R12_14305 ENOG4105TRT Transcriptional regulator A1R12_14320 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj A1R12_14325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) A1R12_14345 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) A1R12_14355 ENOG4105EE0 oxidoreductase A1R12_14360 ENOG4108Z0Z intracellular protease Pfpi family A1R12_14365 ENOG4105C8Q Methyl-accepting chemotaxis A1R12_14370 ENOG4105C8Q Methyl-accepting chemotaxis A1R12_14375 ENOG4105C8Q Methyl-accepting chemotaxis A1R12_14380 ENOG4105C8Q Methyl-accepting chemotaxis A1R12_14395 ENOG4105EA8 2-Nitropropane dioxygenase A1R12_14400 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme A1R12_14410 ENOG4105C37 (CBS) domain A1R12_14425 ENOG4107PBV potassium channel A1R12_14430 ENOG4107PBV potassium channel A1R12_14445 ENOG4107QYV phosphohexose isomerase A1R12_14460 ENOG4105CHJ isochorismatase hydrolase A1R12_14470 ENOG4107QW4 alcohol dehydrogenase A1R12_14475 ENOG4105WG9 Conserved Protein A1R12_14485 ENOG4105CHM Aminotransferase A1R12_14490 ENOG4108ZB6 transcriptional regulator AsnC family A1R12_14495 ENOG4108MUZ hydrolase A1R12_14505 ENOG4105C87 Aminotransferase class I and II A1R12_14510 ENOG4108HGU Histidine kinase A1R12_14515 ENOG4105Y38 Kinase-associated protein B A1R12_14530 ENOG4105BZ4 penicillin-binding protein A1R12_14535 ENOG4105KIR Thiol-disulfide oxidoreductase dcc A1R12_14550 ENOG4108MRH transcriptional regulatory protein A1R12_14555 ENOG4105DIH basic membrane A1R12_14560 ENOG4108JQ9 ABC transporter A1R12_14565 ENOG4105UIB (ABC) transporter A1R12_14580 ENOG4105D65 subunit l A1R12_14585 ENOG4105HC0 Na H antiporter A1R12_14590 ENOG4108ZE9 Monovalent cation H antiporter subunit C A1R12_14595 ENOG4108JPZ Monovalent cation H antiporter subunit D A1R12_14600 ENOG4105SC1 monovalent cation H antiporter subunit E A1R12_14610 ENOG4105KJM monovalent cation h antiporter subunit g A1R12_14615 ENOG4105KA0 thioesterase Superfamily protein A1R12_14625 ENOG4105BZU Histidine kinase A1R12_14650 ENOG4105D58 Diguanylate phosphodiesterase A1R12_14655 ENOG4105DAP Nicotinate phosphoribosyltransferase A1R12_14680 ENOG4105C02 permease A1R12_14695 ENOG410904N short-chain dehydrogenase reductase A1R12_14730 ENOG4108K8K Transcriptional regulator A1R12_14735 ENOG4105DCF alanine dehydrogenase A1R12_14745 ENOG4105WQT MbtH domain protein A1R12_14750 ENOG4105CEY Amp-dependent synthetase and ligase A1R12_14755 ENOG4105WQI isochorismatase A1R12_14760 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase A1R12_14765 ENOG4105E4F Isochorismate synthase A1R12_14770 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase A1R12_14775 ENOG4105NIV Esterase A1R12_14795 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) A1R12_14805 ENOG41069ER domain protein A1R12_14815 ENOG4105CEP NADH dehydrogenase A1R12_14830 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) A1R12_14845 ENOG4105CJ1 ABC, transporter A1R12_14870 ENOG4108VHC Short-chain dehydrogenase reductase Sdr A1R12_14875 ENOG4108YX9 iron--sulfur cluster insertion protein erpA A1R12_14880 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) A1R12_14890 ENOG4105ZKE UPF0349 protein A1R12_14905 ENOG41083MR nifu domain-containing protein A1R12_14910 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein A1R12_14915 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) A1R12_14920 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) A1R12_14925 ENOG4105D6E homoserine dehydrogenase A1R12_14935 ENOG4108W5N phosphatidylglycerophosphatase a A1R12_14940 ENOG4105D4U had-superfamily hydrolase, subfamily iia A1R12_14950 ENOG4105MMD transcriptional regulator A1R12_14955 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) A1R12_14960 ENOG4105FAA peptidase M23 A1R12_14965 ENOG4108YTE sporulation protein YunB A1R12_14970 ENOG4107R8B 5'-nucleotidase A1R12_14980 ENOG4105I3N Conserved Protein A1R12_14990 ENOG4105CD3 dihydroorotase A1R12_14995 ENOG4105G9B Transcriptional regulator A1R12_15020 ENOG4105C5R Aminotransferase A1R12_15030 ENOG4108K8S endonuclease I A1R12_15035 ENOG4108IJ9 (ABC) transporter A1R12_15040 ENOG4105FDP GntR family transcriptional regulator A1R12_15045 ENOG4108KPW sugar kinase A1R12_15050 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component A1R12_15055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component A1R12_15060 ENOG4105XN3 extracellular solute-binding protein family 1 A1R12_15065 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine A1R12_15085 ENOG4105PKS Excinuclease abc c subunit domain protein A1R12_15090 ENOG4107VFR oxidoreductase A1R12_15095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) A1R12_15105 ENOG41083Q9 chitosanase A1R12_15110 ENOG4105DIW FeS assembly protein SUFB A1R12_15115 ENOG4108UNV SUF system FeS assembly protein, NifU family A1R12_15120 ENOG4105C9B Cysteine desulfurase A1R12_15125 ENOG4105JRK feS assembly protein SufD A1R12_15130 ENOG4105C3K feS assembly ATPase SufC A1R12_15140 ENOG4105D01 (LipO)protein A1R12_15145 ENOG4108UMI ABC transporter, permease A1R12_15150 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) A1R12_15175 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) A1R12_15180 ENOG41080E8 Transcriptional regulator, Spx MgsR family A1R12_15185 ENOG4105C1G acyl-Coa dehydrogenase A1R12_15190 ENOG4105CHU acetyl-coa acetyltransferase A1R12_15220 ENOG41067TZ transcriptional regulator, MarR family A1R12_15225 ENOG4105C0R drug resistance transporter emrb qaca subfamily A1R12_15230 ENOG4105MDS 4-oxalocrotonate tautomerase A1R12_15240 ENOG4105EGI Transcriptional regulator A1R12_15245 ENOG4105C5Q Transcriptional regulator A1R12_15265 ENOG4105E0A ABC, transporter A1R12_15280 ENOG4105E1F short-chain dehydrogenase reductase A1R12_15285 ENOG4105HUF DNA protection during starvation protein A1R12_15290 ENOG4105C0H protease A1R12_15300 ENOG4105F3H Histidine kinase A1R12_15305 ENOG41067SE Tetr family transcriptional regulator A1R12_15310 ENOG4105C9Q fumarate hydratase class II A1R12_15335 ENOG4105WH1 Two component transcriptional regulator luxr family A1R12_15340 ENOG4105ENE Histidine kinase A1R12_15355 ENOG41087YS Phage shock protein A A1R12_15370 ENOG4108WBT adenosyltransferase A1R12_15375 ENOG4105E0A ABC, transporter A1R12_15380 ENOG4105EHG Permease protein A1R12_15385 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) A1R12_15390 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A1R12_15395 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein A1R12_15405 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A1R12_15415 ENOG4106DF4 Sigma-70, region 4 A1R12_15420 ENOG4105F0F Oxalate decarboxylase A1R12_15430 ENOG4105E0A ABC, transporter A1R12_15435 ENOG4105EHG Permease protein A1R12_15440 ENOG4105DQ5 transport system permease protein A1R12_15450 ENOG4105JQZ Methyltransferase A1R12_15455 ENOG4105D5Q Arginine ornithine antiporter A1R12_15465 ENOG4107K5X Membrane-bound metal-dependent hydrolase A1R12_15470 ENOG4107QZ2 Sulfatase A1R12_15475 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family A1R12_15480 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein A1R12_15485 ENOG4105E0C molybdate abc transporter A1R12_15490 ENOG4105WH1 Two component transcriptional regulator luxr family A1R12_15495 ENOG4105BZU Histidine kinase A1R12_15500 ENOG4105CJ1 ABC, transporter A1R12_15510 ENOG4108KYE ABC-2 type transporter A1R12_15525 ENOG4105EEQ Na H antiporter A1R12_15535 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) A1R12_15540 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) A1R12_15545 ENOG4105EEM helicase A1R12_15550 ENOG4105EN6 Membrane A1R12_15565 ENOG4107ZQN disulfide bond A1R12_15570 ENOG4105C59 p-type ATPase A1R12_15575 ENOG4105C59 p-type ATPase A1R12_15580 ENOG410681U heavy metal transport detoxification protein A1R12_15585 ENOG4105VPX protein, conserved in bacteria A1R12_15590 ENOG4105D9R oxidoreductase A1R12_15595 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) A1R12_15610 ENOG4105DEN Luciferase family A1R12_15615 ENOG4105CDA abc transporter atp-binding protein A1R12_15640 ENOG4108XSB acetyltransferase, (GNAT) family A1R12_15645 ENOG4108KSA LysR family transcriptional regulator A1R12_15650 ENOG4105EWI Short-chain dehydrogenase reductase Sdr A1R12_15655 ENOG41067XF inhibitor A1R12_15665 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) A1R12_15670 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) A1R12_15680 ENOG4105XZU Preprotein translocase, subunit SecG A1R12_15700 ENOG4105KVH Transcriptional regulator A1R12_15725 ENOG4105DA5 (ABC) transporter A1R12_15730 ENOG4105R40 Glycine betaine carnitine choline A1R12_15735 ENOG4108HQR Glycine betaine A1R12_15740 ENOG4105E90 ABC transporter A1R12_15745 ENOG4108IJ8 ABC transporter A1R12_15750 ENOG4107HG4 Transcriptional regulator A1R12_15755 ENOG4105R40 Glycine betaine carnitine choline A1R12_15760 ENOG4108HQR Glycine betaine A1R12_15765 ENOG4105E90 ABC transporter A1R12_15770 ENOG4108IJ8 ABC transporter A1R12_15775 ENOG4107HG4 Transcriptional regulator A1R12_15780 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein A1R12_15795 ENOG4105T65 Membrane-associated protein A1R12_15800 ENOG4108W0I acetyltransferase A1R12_15815 ENOG4105FJR Lmbe family A1R12_15830 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A1R12_15835 ENOG4108IAJ Nad-dependent epimerase dehydratase A1R12_15840 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A1R12_15845 ENOG4107QQG Dehydrogenase A1R12_15850 ENOG4105IIU Aminopeptidase A1R12_15855 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) A1R12_15860 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) A1R12_15865 ENOG4105CP7 Triose-phosphate isomerase A1R12_15870 ENOG4105BZA Phosphoglycerate kinase A1R12_15880 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase A1R12_15895 ENOG4105CMD Transcriptional regulator, GntR family A1R12_15905 ENOG4105DEN Luciferase family A1R12_15910 ENOG4105GZI Transcriptional regulator A1R12_15915 ENOG4107RT3 EamA-like transporter family A1R12_15940 ENOG410667J hydrolase A1R12_15945 ENOG4106KNT transcriptional regulator A1R12_15950 ENOG4105CMG Carbohydrate kinase A1R12_15955 ENOG4105C6Z Gluconate A1R12_15965 ENOG4107QR9 Iron-sulfur cluster binding protein A1R12_15970 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) A1R12_15975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family A1R12_15980 ENOG4105JXH GntR family transcriptional regulator A1R12_15985 ENOG4105DAA L-lactate A1R12_15990 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) A1R12_16000 ENOG4108ZPC Polysaccharide pyruvyl transferase A1R12_16005 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A1R12_16010 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family A1R12_16015 ENOG4105D3Q Sugar transferase A1R12_16025 ENOG4105K64 Glycosyl transferase, family 2 A1R12_16035 ENOG4107QRS glycosyltransferase group 2 family protein A1R12_16040 ENOG41068W6 Capsular polysaccharide biosynthesis protein A1R12_16045 ENOG4108KMV Glycosyl transferase (Group 1 A1R12_16050 ENOG4105K64 Glycosyl transferase, family 2 A1R12_16055 ENOG4108PQP glycosyl transferase group 1 A1R12_16065 ENOG4108QV3 biosynthesis protein A1R12_16070 ENOG4105HTX biosynthesis protein A1R12_16080 ENOG4105EBR Carboxylesterase A1R12_16085 ENOG4105NAE bifunctional deaminase-reductase domain protein A1R12_16095 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 A1R12_16100 ENOG4105PY6 Phenolic acid decarboxylase A1R12_16155 ENOG4108HKT sucrose-6-phosphate hydrolase A1R12_16160 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) A1R12_16165 ENOG4105ETE Transcriptional regulator (LacI family A1R12_16170 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) A1R12_16175 ENOG4108KAM Transcriptional regulator A1R12_16180 ENOG4105C7F AcnD-accessory protein PrpF A1R12_16190 ENOG4108URH decarboxylase A1R12_16195 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain A1R12_16200 ENOG4105CHH sulfate transporter A1R12_16205 ENOG4108V2W Carbonate dehydratase A1R12_16215 ENOG4105C5I Dehydrogenase A1R12_16220 ENOG4105CHH sulfate transporter A1R12_16225 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase A1R12_16230 ENOG4105KRI phosphocarrier protein (HPr A1R12_16235 ENOG4105CIE May be required for sporulation (By similarity) A1R12_16240 ENOG4105CHW UPF0052 protein A1R12_16245 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) A1R12_16250 ENOG4108Z4K mutator MutT protein A1R12_16255 ENOG4105C3M thioredoxin reductase A1R12_16270 ENOG4105BZU Histidine kinase A1R12_16275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A1R12_16280 ENOG4105GIG A1R12_16285 ENOG4105BZ1 (ABC) transporter A1R12_16290 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase A1R12_16295 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) A1R12_16300 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase A1R12_16305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) A1R12_16310 ENOG4105ECC imidazole-glycerol-phosphate dehydratase A1R12_16315 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) A1R12_16320 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) A1R12_16325 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) A1R12_16335 ENOG4108S4C acetyltransferase A1R12_16340 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) A1R12_16350 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) A1R12_16355 ENOG4105CE4 GlcNAc 6-P deacetylase A1R12_16360 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) A1R12_16365 ENOG4105FDP GntR family transcriptional regulator A1R12_16370 ENOG4105J7D transcriptional regulator A1R12_16375 ENOG41088CQ domain protein A1R12_16380 ENOG41086DT Membrane protein of unknown function A1R12_16385 ENOG41067S9 phage shock protein C, PspC A1R12_16390 ENOG4108PY7 A1R12_16405 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) A1R12_16410 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) A1R12_16425 ENOG4105MKU Transcriptional regulator A1R12_16490 ENOG4105CN1 protease A1R12_16495 ENOG4108M26 parallel beta-helix repeat protein A1R12_16500 ENOG4105CRP Part of the ABC transporter FtsEX involved in A1R12_16505 ENOG4105CAK Cell division ATP-binding protein ftsE A1R12_16520 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) A1R12_16525 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving A1R12_16530 ENOG4105MS2 ribosomal subunit Interface protein A1R12_16545 ENOG4105MQ3 flagellar protein FliS A1R12_16550 ENOG4107RT6 flagellar hook-associated A1R12_16555 ENOG4105I03 Flagellin A1R12_16560 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) A1R12_16565 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) A1R12_16575 ENOG4105DTJ flagellar hook-associated protein A1R12_16580 ENOG4105E1Q flagellar hook-associated protein A1R12_16595 ENOG4105RU3 A1R12_16600 ENOG41081UC Inherit from COG: Competence protein A1R12_16620 ENOG4105WH1 Two component transcriptional regulator luxr family A1R12_16625 ENOG4105BZU Histidine kinase A1R12_16630 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein A1R12_16635 ENOG4108KGH TRANSCRIPTIONal A1R12_16640 ENOG4105ESV Glycosyl transferase, family 4 A1R12_16645 ENOG4107EF8 Glycosyl transferase (Group 1 A1R12_16660 ENOG4105QZI O-Antigen Polymerase A1R12_16665 ENOG4105C6Y Udp-glucose 6-dehydrogenase A1R12_16670 ENOG4107RA4 Glycosyl transferase (Group 1 A1R12_16675 ENOG4105PSV Polysaccharide Biosynthesis Protein A1R12_16680 ENOG4105D3Q Sugar transferase A1R12_16685 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase A1R12_16690 ENOG4105JFG SpoIID LytB domain protein A1R12_16705 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase A1R12_16710 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase A1R12_16715 ENOG4105EY8 ABC transporter A1R12_16725 ENOG4107SJB teichoic acid biosynthesis A1R12_16735 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase A1R12_16745 ENOG4107RZX Teichoic acid biosynthesis protein A1R12_16755 ENOG4105DG6 mannose-6-phosphate isomerase A1R12_16770 ENOG4108NHD germination protein A1R12_16775 ENOG4107R8N Glycosyl transferase, family 2 A1R12_16780 ENOG4105C54 Major Facilitator superfamily A1R12_16785 ENOG4108KGH TRANSCRIPTIONal A1R12_16790 ENOG4105J7I hydrolase A1R12_16795 ENOG4106UBQ A1R12_16800 ENOG4105K4H Nlp p60 protein A1R12_16805 ENOG4105PNM synthesis protein A1R12_16815 ENOG4105N98 Capsule biosynthesis protein capB A1R12_16820 ENOG4105E1K spore germination protein A1R12_16835 ENOG4105ETE Transcriptional regulator (LacI family A1R12_16840 ENOG4108RVA ribokinase A1R12_16845 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) A1R12_16850 ENOG4105C2J ABC transporter A1R12_16855 ENOG4105CNN ABC, transporter A1R12_16860 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator A1R12_16870 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein A1R12_16875 ENOG4107FQX Alpha-acetolactate decarboxylase A1R12_16885 ENOG4107RSM transcriptional regulator A1R12_16900 ENOG4106UIA A1R12_16915 ENOG4107XC4 flavin reductase domain protein, FMN-binding A1R12_16925 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) A1R12_16935 ENOG4105CAH Chromate A1R12_16940 ENOG4105FGV Chromate A1R12_16945 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) A1R12_16980 ENOG4108XI2 Domain of unknown function (DUF1963) A1R12_16985 ENOG4105C6Y Udp-glucose 6-dehydrogenase A1R12_16990 ENOG4108RB3 Capsular polysaccharide biosynthesis protein A1R12_16995 ENOG4107YJ4 chain length determinant protein A1R12_17000 ENOG4105HTX biosynthesis protein A1R12_17005 ENOG4105KBK Zinc finger, swim domain protein A1R12_17010 ENOG4105C0D helicase A1R12_17015 ENOG410667J hydrolase A1R12_17020 ENOG4105E98 transcriptional regulator DeoR family A1R12_17025 ENOG4105Z8H single-stranded DNA-binding protein A1R12_17040 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) A1R12_17045 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) A1R12_17055 ENOG4105CGA flagellar basal-body rod protein FlgG A1R12_17065 ENOG4105DFF Rod shape-determining protein mreb A1R12_17070 ENOG4105MT0 Sporulation transcriptional regulator spoiiid A1R12_17075 ENOG4107MII Sugar-specific transcriptional regulator TrmB A1R12_17080 ENOG4105CZM Major Facilitator A1R12_17085 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease A1R12_17090 ENOG41080V3 Major Facilitator superfamily A1R12_17095 ENOG4105D3W isochorismatase A1R12_17100 ENOG4105BZU Histidine kinase A1R12_17110 ENOG4105CNI cell division protein FtsW A1R12_17115 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase A1R12_17125 ENOG4105FRN stage II sporulation protein A1R12_17130 ENOG4107TCE N-acetyltransferase A1R12_17145 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A1R12_17150 ENOG4106BRK A1R12_17160 ENOG4107T94 Endo-14-beta-xylanase A1R12_17165 ENOG4108Z40 Transcriptional regulator A1R12_17170 ENOG4105CQM Urea amidohydrolase subunit alpha A1R12_17175 ENOG4105KI2 Urea amidohydrolase subunit beta A1R12_17180 ENOG4108YZ9 Urea amidohydrolase subunit gamma A1R12_17200 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) A1R12_17205 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) A1R12_17210 ENOG4108TF4 von Willebrand factor, type A A1R12_17225 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A1R12_17235 ENOG4106778 Protein of unknown function (DUF1146) A1R12_17245 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) A1R12_17250 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) A1R12_17255 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) A1R12_17260 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) A1R12_17265 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) A1R12_17280 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) A1R12_17290 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) A1R12_17295 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) A1R12_17300 ENOG4108UIC UPF0340 protein A1R12_17305 ENOG4108YZG isomerase A1R12_17310 ENOG4107WAU Protein tyrosine phosphatase A1R12_17315 ENOG410815N Probably functions as a manganese efflux pump (By similarity) A1R12_17320 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) A1R12_17330 ENOG4108ZXQ stage ii sporulation protein r A1R12_17345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) A1R12_17350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) A1R12_17355 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase A1R12_17365 ENOG4107TT2 Auxin Efflux Carrier A1R12_17370 ENOG4105C6K Malic enzyme A1R12_17375 ENOG4107104 thymidine kinase A1R12_17380 ENOG41082DI 50s ribosomal protein l31 A1R12_17385 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) A1R12_17390 ENOG4105CBT Fructose-1,6-bisphosphatase A1R12_17395 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) A1R12_17405 ENOG4105D2N Aldolase A1R12_17410 ENOG410812K response regulator receiver protein A1R12_17420 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) A1R12_17430 ENOG4105DF6 Fe-S oxidoreductase A1R12_17440 ENOG4105E5J UV damage endonuclease A1R12_17450 ENOG4105BZ1 (ABC) transporter A1R12_17455 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) A1R12_17470 ENOG4105R3A Nitrate reductase A1R12_17475 ENOG4108IUE nitrate reductase beta subunit A1R12_17495 ENOG4107V6Q Cyclic nucleotide-binding domain A1R12_17505 ENOG4105C75 arginyL-tRNA synthetase A1R12_17510 ENOG410684U Domain of unknown function (DUF1934) A1R12_17530 ENOG4107JM4 Tetratricopeptide repeat A1R12_17575 ENOG4105CYW agmatinase A1R12_17580 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) A1R12_17585 ENOG4105BZ4 penicillin-binding protein A1R12_17595 ENOG4108XFG YwhD family A1R12_17600 ENOG4108Z4T Peptidase M50 A1R12_17605 ENOG41069HH 4-oxalocrotonate tautomerase A1R12_17610 ENOG41067TZ transcriptional regulator, MarR family A1R12_17615 ENOG4105CUB amino acid A1R12_17625 ENOG4105DCI Phosphohydrolase A1R12_17635 ENOG4108VCI transcription factor, rsfa family A1R12_17640 ENOG4105K7K Transcriptional regulator A1R12_17650 ENOG4105CJ1 ABC, transporter A1R12_17655 ENOG4108TU7 Inherit from COG: (ABC) transporter A1R12_17680 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) A1R12_17685 ENOG4105DUM transcriptional regulator, lysR family A1R12_17690 ENOG4105HMI Membrane A1R12_17695 ENOG4108IJ2 phosphate acetyltransferase A1R12_17700 ENOG4107JTW chlorite dismutase A1R12_17710 ENOG4105CHM Aminotransferase A1R12_17740 ENOG4105FCW Major Facilitator superfamily A1R12_17745 ENOG4105C2C drug resistance transporter, Bcr CflA A1R12_17760 ENOG4105C26 Dehydrogenase A1R12_17765 ENOG4105D82 Glutamate dehydrogenase A1R12_17775 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase A1R12_17780 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase A1R12_17785 ENOG4105C1B dTDP-glucose 4-6-dehydratase A1R12_17790 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) A1R12_17795 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG A1R12_17800 ENOG4107TY6 Acylneuraminate cytidylyltransferase A1R12_17810 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD A1R12_17815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase A1R12_17850 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) A1R12_17855 ENOG4108RJ9 Glycosyl transferase, family 2 A1R12_17860 ENOG4105DWF phosphomethylpyrimidine kinase A1R12_17875 ENOG4105C5Y PTS System A1R12_17890 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin A1R12_17895 ENOG4105DEN Luciferase family A1R12_17900 ENOG4108DBC nitroreductase A1R12_17910 ENOG4105I4A GCN5-related N-acetyltransferase A1R12_17930 ENOG4105BZ9 Cytochrome C oxidase, subunit I A1R12_17935 ENOG4105E2S oxidase) subunit II A1R12_17940 ENOG4107BMA Transglycosylase associated protein A1R12_17950 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) A1R12_17955 ENOG4105WH5 Teichoic acid glycosylation protein A1R12_17980 ENOG4107ZXU DSBA oxidoreductase A1R12_17985 ENOG4105DBE peroxidase A1R12_17990 ENOG410650H (LipO)protein A1R12_17995 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) A1R12_18000 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase A1R12_18005 ENOG4105CMU LysR family (Transcriptional regulator A1R12_18010 ENOG4105VAW lrga family A1R12_18015 ENOG41067MG lrgb family A1R12_18025 ENOG4107TXC Transcriptional regulator A1R12_18035 ENOG4105DR4 Methyltransferase A1R12_18045 ENOG4105CK1 PTS System A1R12_18050 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin A1R12_18055 ENOG4105X1N Glycosyl transferase family 8 A1R12_18070 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase A1R12_18080 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) A1R12_18085 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein A1R12_18090 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) A1R12_18095 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD A1R12_18100 ENOG4105CM2 brancheD-chain amino acid aminotransferase A1R12_18105 ENOG4105F8D glycoside hydrolase family 4 A1R12_18110 ENOG4105VCP PTS System A1R12_18115 ENOG4105CK1 PTS System A1R12_18120 ENOG4105VZJ PTS System A1R12_18125 ENOG4105EMD TRANSCRIPTIONal A1R12_18135 ENOG4105DQ5 transport system permease protein A1R12_18140 ENOG4105EHG Permease protein A1R12_18150 ENOG41082YX Transcriptional regulator, arsr family A1R12_18155 ENOG4107R5R arsenical pump membrane protein A1R12_18160 ENOG4105VZJ PTS System A1R12_18165 ENOG4105VCP PTS System A1R12_18170 ENOG4105CK1 PTS System A1R12_18175 ENOG4105CS2 ec 3.2.1.21 A1R12_18180 ENOG4105EVU fructokinase A1R12_18185 ENOG4105DG6 mannose-6-phosphate isomerase A1R12_18195 ENOG4105CH6 catalase A1R12_18200 ENOG4107QHE Choloylglycine hydrolase A1R12_18205 ENOG4105ETS cytosine purines uracil thiamine allantoin A1R12_18210 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) A1R12_18215 ENOG4108JJ8 (ABC) transporter A1R12_18220 ENOG4108JJ9 ABC, transporter A1R12_18225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii A1R12_18230 ENOG4105C4M (Ubiquinol oxidase) subunit I A1R12_18235 ENOG4105D2K citrate carrier protein A1R12_18240 ENOG4107BJW polysaccharide deacetylase A1R12_18255 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) A1R12_18265 ENOG4105CMR udp-glucose 4-epimerase A1R12_18270 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) A1R12_18285 ENOG4105DHI Methyltransferase A1R12_18310 ENOG4105CH6 catalase A1R12_18315 ENOG4105D4T Citrate transporter A1R12_18325 ENOG4105CID antiterminator A1R12_18330 ENOG4105DEU major facilitator superfamily A1R12_18335 ENOG4105C1J atp-dependent rna helicase A1R12_18405 ENOG4108NR7 pectate lyase A1R12_18415 ENOG4107YZX Universal stress protein A1R12_18460 ENOG4106Z5D Glycoside Hydrolase Family 43 A1R12_18470 ENOG4105C84 Histidine ammonia-lyase A1R12_18475 ENOG4105CGP Urocanate hydratase A1R12_18480 ENOG4105CI2 imidazolone-5-propionate hydrolase A1R12_18485 ENOG4107W25 arginase agmatinase formiminoglutamase A1R12_18495 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) A1R12_18500 ENOG4105D9N nucleoside A1R12_18505 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) A1R12_18510 ENOG4107RHR regulatoR A1R12_18515 ENOG410667J hydrolase A1R12_18545 ENOG4108V5C ABC transporter A1R12_18580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family A1R12_18605 ENOG4105WZ4 isomerase A1R12_18610 ENOG4105F0H myo-inositol catabolism protein A1R12_18615 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) A1R12_18625 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) A1R12_18635 ENOG4105EDK PfkB domain protein A1R12_18645 ENOG4105C26 Dehydrogenase A1R12_18655 ENOG4105CPC Aldo Keto reductase A1R12_18660 ENOG4107QNK )-transporter A1R12_18665 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) A1R12_18675 ENOG41061TZ Short-chain dehydrogenase reductase Sdr A1R12_18680 ENOG4108S01 response regulator A1R12_18685 ENOG4108ZGX Histidine kinase A1R12_18690 ENOG4105ECK Fatty Acid Desaturase A1R12_18700 ENOG4105ST3 Transcriptional regulator A1R12_18705 ENOG4105C26 Dehydrogenase A1R12_18710 ENOG4108ITS PQQ enzyme repeat A1R12_18720 ENOG4105WAB arsR family transcriptional regulator A1R12_18725 ENOG4105F27 Major Facilitator A1R12_18730 ENOG41085PJ rdd domain containing protein A1R12_18740 ENOG4105D3R alkyl hydroperoxide reductase A1R12_18745 ENOG4108JU3 Alkyl hydroperoxide reductase A1R12_18755 ENOG4105C85 amino acid A1R12_18760 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 A1R12_18765 ENOG4108XHQ (2Fe-2S)-binding domain protein A1R12_18785 ENOG4105XRQ Xanthine dehydrogenase accessory factor A1R12_18820 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) A1R12_18840 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) A1R12_18845 ENOG4105CPC Aldo Keto reductase A1R12_18850 ENOG4105WQG acetyltransferase A1R12_18860 ENOG41066UZ arginase EC 3.5.3.1 A1R12_18865 ENOG4108IQI permease A1R12_18870 ENOG4105C8Y Acetylornithine aminotransferase A1R12_18880 ENOG41082BM Transcriptional regulator, arsr family A1R12_18885 ENOG4108JUB Transcriptional regulator A1R12_18895 ENOG4105C5H ABC transporter A1R12_18910 ENOG4105D06 uba thif-type nad fad binding protein A1R12_18915 ENOG41062D9 Histidine kinase A1R12_18920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A1R12_18925 ENOG4105C0H protease A1R12_18930 ENOG4105Q2H domain protein A1R12_18945 ENOG4105BZU Histidine kinase A1R12_18950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family A1R12_18980 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis A1R12_18985 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase A1R12_18990 ENOG4105CDU Replicative dna helicase A1R12_19005 ENOG4105EDW glycosyl transferase, family 39 A1R12_19010 ENOG4107QPH glycogen) synthase A1R12_19020 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR A1R12_19025 ENOG4105CPK Glycosyl transferase (Group 1 A1R12_19045 ENOG4105DQ6 Transposase A1R12_19055 ENOG4105BZR domain protein A1R12_19060 ENOG4108XMW Membrane A1R12_19070 ENOG4105KVH Transcriptional regulator A1R12_19075 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase A1R12_19080 ENOG4108UZ3 Transporter A1R12_19090 ENOG4108HKT sucrose-6-phosphate hydrolase A1R12_19095 ENOG4107XBN GntR Family Transcriptional Regulator A1R12_19110 ENOG4106UX7 integral membrane protein A1R12_19120 ENOG4108TVJ Nitroreductase A1R12_19125 ENOG4105FS7 Transcriptional regulator A1R12_19135 ENOG4108U05 Transcriptional regulator A1R12_19140 ENOG41082BV acetyltransferase A1R12_19150 ENOG4107XGZ Hydrolase A1R12_19190 ENOG4107Y9U Membrane A1R12_19195 ENOG4107TVP HD domain protein A1R12_19205 ENOG4108Z5V transcriptional regulator, merr family A1R12_19210 ENOG4108UQV Membrane A1R12_19215 ENOG4105C7Z Conserved Protein A1R12_19220 ENOG4107FCW Abortive infection protein A1R12_19230 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase A1R12_19240 ENOG4105CGK Exodeoxyribonuclease III A1R12_19245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) A1R12_19255 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) A1R12_19260 ENOG4108UUM single-stranded DNA-binding protein A1R12_19265 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) A1R12_19270 ENOG4105C3G gtp-binding protein A1R12_19275 ENOG4108J2R molybdopterin oxidoreductase A1R12_19280 ENOG4105VDK protein, conserved in bacteria A1R12_19295 ENOG4108ZDA Sporulation protein YyaC A1R12_19300 ENOG4105FA0 parb-like partition protein A1R12_19305 ENOG4107QJE Chromosome Partitioning Protein A1R12_19320 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) A1R12_19325 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) A1R12_19340 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) A1R12_19345 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) A1R12_19350 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) A1R12_19355 ENOG410848D S4 domain protein YaaA A1R12_19360 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) A1R12_19370 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) A1R12_19375 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)