locus-tag	class	description
A1R12_00010	COG0592	DNA-directed DNA polymerase activity
A1R12_00015	COG2501	S4 domain
A1R12_00030	COG0187	DNA topoisomerase II activity
A1R12_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1R12_00060	COG0516	GMP reductase activity
A1R12_00060	COG0517	IMP dehydrogenase activity
A1R12_00065	COG1686	Belongs to the peptidase S11 family
A1R12_00085	COG1929	Belongs to the glycerate kinase type-1 family
A1R12_00095	COG1428	Deoxynucleoside kinase
A1R12_00100	COG1428	Deoxynucleoside kinase
A1R12_00105	COG3858	chitin binding
A1R12_00105	COG1388	LysM domain
A1R12_00110	COG1335	isochorismatase
A1R12_00115	COG0590	tRNA wobble adenosine to inosine editing
A1R12_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A1R12_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A1R12_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A1R12_00170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
A1R12_00175	COG3853	Toxic anion resistance protein (TelA)
A1R12_00180	COG1982	Orn Lys Arg decarboxylase major
A1R12_00190	COG3870	Protein conserved in bacteria
A1R12_00195	COG1728	Protein conserved in bacteria
A1R12_00200	COG0470	DNA polymerase III
A1R12_00205	COG1774	PSP1 C-terminal conserved region
A1R12_00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A1R12_00225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A1R12_00230	COG2002	toxin-antitoxin pair type II binding
A1R12_00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1R12_00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1R12_00240	COG0084	hydrolase, TatD family'
A1R12_00245	COG3584	3D domain protein
A1R12_00245	COG3583	domain protein
A1R12_00250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A1R12_00255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A1R12_00265	COG4466	Protein conserved in bacteria
A1R12_00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A1R12_00285	COG0251	oxidation-reduction process
A1R12_00300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A1R12_00320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A1R12_00325	COG2002	toxin-antitoxin pair type II binding
A1R12_00330	COG2244	polysaccharide biosynthetic process
A1R12_00335	COG3956	TIGRFAM MazG family protein
A1R12_00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A1R12_00355	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A1R12_00360	COG1098	S1 RNA binding domain
A1R12_00375	COG2208	phosphoserine phosphatase activity
A1R12_00380	COG2304	oxidoreductase activity
A1R12_00385	COG0515	serine threonine protein kinase
A1R12_00390	COG0037	tRNA processing
A1R12_00400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A1R12_00415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1R12_00420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1R12_00425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1R12_00430	COG0512	Glutamine amidotransferase of anthranilate synthase
A1R12_00435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1R12_00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A1R12_00445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A1R12_00450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A1R12_00455	COG1396	sequence-specific DNA binding
A1R12_00460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1R12_00465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A1R12_00550	COG4463	regulation of RNA biosynthetic process
A1R12_00555	COG3880	PFAM UvrB UvrC protein
A1R12_00565	COG0542	response to heat
A1R12_00570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A1R12_00575	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A1R12_00580	COG4956	integral membrane protein (PIN domain superfamily)
A1R12_00600	COG1045	serine acetyltransferase
A1R12_00610	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A1R12_00615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1R12_00620	COG3688	RNA-binding protein containing a PIN domain
A1R12_00625	COG1595	DNA-templated transcription, initiation
A1R12_00630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A1R12_00635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1R12_00640	COG0250	Participates in transcription elongation, termination and antitermination
A1R12_00645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A1R12_00660	COG0222	ribosome binding
A1R12_00665	COG2813	Specifically methylates the guanine in position
A1R12_00680	COG1358	cellular component organization or biogenesis
A1R12_00705	COG0596	Alpha beta hydrolase
A1R12_00710	COG0051	transcription antitermination factor activity, RNA binding
A1R12_00725	COG0089	rRNA binding
A1R12_00735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A1R12_00740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A1R12_00750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A1R12_00755	COG0255	Belongs to the universal ribosomal protein uL29 family
A1R12_00800	COG1841	ribosomal large subunit assembly
A1R12_00810	COG0201	protein transport
A1R12_00820	COG0024	Methionine aminopeptidase
A1R12_00825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A1R12_00830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A1R12_00855	COG1122	ATPase activity
A1R12_00860	COG1122	ATPase activity
A1R12_00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A1R12_00885	COG2226	methyltransferase
A1R12_00890	COG2318	DinB family
A1R12_00900	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_00905	COG0489	protein tyrosine kinase activity
A1R12_00915	COG2194	sulfuric ester hydrolase activity
A1R12_00920	COG0726	polysaccharide deacetylase
A1R12_01020	COG0738	Major facilitator superfamily
A1R12_01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1R12_01040	COG0659	secondary active sulfate transmembrane transporter activity
A1R12_01045	COG0385	Bile acid
A1R12_01050	COG2819	hydrolase of the alpha beta superfamily
A1R12_01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1R12_01070	COG2207	Transcriptional regulator
A1R12_01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1R12_01075	COG3876	Protein conserved in bacteria
A1R12_01080	COG1472	Belongs to the glycosyl hydrolase 3 family
A1R12_01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1R12_01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_01090	COG1263	PTS System
A1R12_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1R12_01105	COG1683	Conserved Protein
A1R12_01135	COG1595	DNA-templated transcription, initiation
A1R12_01140	COG5662	AntiSigma factor
A1R12_01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A1R12_01150	COG4856	YbbR-like protein
A1R12_01205	COG1346	cytolysis
A1R12_01210	COG1380	Effector of murein hydrolase LrgA
A1R12_01215	COG1846	Transcriptional regulator
A1R12_01220	COG1113	amino acid transport
A1R12_01225	COG1011	Hydrolase
A1R12_01230	COG4585	Histidine kinase
A1R12_01235	COG2197	response regulator
A1R12_01240	COG1131	(ABC) transporter
A1R12_01280	COG0531	amino acid
A1R12_01300	COG0584	glycerophosphoryl diester phosphodiesterase
A1R12_01305	COG2271	Major facilitator Superfamily
A1R12_01315	COG2368	4-hydroxyphenylacetate
A1R12_01325	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_01340	COG0371	Dehydrogenase
A1R12_01350	COG1183	phosphatidylcholine synthase activity
A1R12_01355	COG0586	Pfam SNARE associated Golgi protein
A1R12_01360	COG0688	phosphatidylethanolamine metabolic process
A1R12_01375	COG1301	dicarboxylic acid transport
A1R12_01380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1R12_01385	COG0833	amino acid
A1R12_01390	COG2040	homocysteine
A1R12_01395	COG1115	amino acid carrier protein
A1R12_01400	COG2066	Belongs to the glutaminase family
A1R12_01405	COG4191	Histidine kinase
A1R12_01410	COG0784	Response regulator, receiver
A1R12_01430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A1R12_01435	COG0778	Nitroreductase
A1R12_01440	COG0346	lactoylglutathione lyase activity
A1R12_01445	COG2259	Doxx family
A1R12_01450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_01460	COG3773	Cell wall hydrolase
A1R12_01465	COG3540	Alkaline phosphatase
A1R12_01470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1R12_01475	COG0805	protein transport
A1R12_01485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1R12_01490	COG0477	Major facilitator Superfamily
A1R12_01495	COG1309	transcriptional regulator
A1R12_01500	COG0252	asparaginase activity
A1R12_01505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A1R12_01510	COG1405	negative regulation of cell septum assembly
A1R12_01510	COG3012	SEC-C Motif Domain Protein
A1R12_01515	COG0667	Aldo Keto reductase
A1R12_01525	COG1595	DNA-templated transcription, initiation
A1R12_01530	COG1595	DNA-templated transcription, initiation
A1R12_01535	COG1876	peptidase activity
A1R12_01540	COG0457	Tetratricopeptide repeat
A1R12_01545	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_01550	COG0366	Alpha amylase catalytic
A1R12_01555	COG0803	Belongs to the bacterial solute-binding protein 9 family
A1R12_01560	COG1121	(ABC) transporter
A1R12_01565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A1R12_01570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1R12_01575	COG2310	stress, protein
A1R12_01580	COG2310	stress, protein
A1R12_01585	COG2310	stress, protein
A1R12_01590	COG0861	Integral membrane protein TerC family
A1R12_01600	COG3853	Toxic anion resistance protein (TelA)
A1R12_01605	COG0477	Major facilitator Superfamily
A1R12_01610	COG0517	IMP dehydrogenase activity
A1R12_01610	COG4175	Glycine betaine
A1R12_01615	COG4176	ABC-type proline glycine betaine transport system permease component
A1R12_01620	COG2113	Glycine betaine
A1R12_01625	COG1473	amidohydrolase
A1R12_01630	COG1288	antiporter activity
A1R12_01640	COG0366	Alpha amylase catalytic
A1R12_01650	COG2814	Major facilitator Superfamily
A1R12_01655	COG1846	Transcriptional regulator
A1R12_01660	COG1280	lysine exporter protein (LysE YggA)
A1R12_01665	COG3403	YqcI/YcgG family
A1R12_01670	COG1113	amino acid transport
A1R12_01675	COG3665	Urea carboxylase-associated protein
A1R12_01685	COG2801	Transposase and inactivated derivatives
A1R12_01695	COG1660	Displays ATPase and GTPase activities
A1R12_01700	COG1082	Xylose isomerase domain protein TIM barrel
A1R12_01705	COG2271	Major facilitator Superfamily
A1R12_01710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A1R12_01715	COG3458	cephalosporin-C deacetylase activity
A1R12_01720	COG3541	Predicted nucleotidyltransferase
A1R12_01725	COG0506	proline dehydrogenase activity
A1R12_01730	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_01735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1R12_01740	COG2508	Transcriptional regulator
A1R12_01750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A1R12_01750	COG1587	Uroporphyrinogen-III synthase
A1R12_01755	COG2146	nitrite reductase [NAD(P)H] activity
A1R12_01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1R12_01765	COG0243	molybdopterin cofactor binding
A1R12_01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1R12_01775	COG2223	nitrite transmembrane transporter activity
A1R12_01780	COG0523	cobalamin synthesis protein
A1R12_01785	COG1063	alcohol dehydrogenase
A1R12_01790	COG1714	RDD family
A1R12_01810	COG3209	COG3209 Rhs family protein
A1R12_01815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1R12_01820	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A1R12_01825	COG1733	regulation of RNA biosynthetic process
A1R12_01835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_01840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_01850	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A1R12_01865	COG0697	spore germination
A1R12_01880	COG2364	Membrane
A1R12_01885	COG1126	abc transporter atp-binding protein
A1R12_01890	COG0765	amino acid transport
A1R12_01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_01900	COG0583	DNA-binding transcription factor activity
A1R12_01905	COG0163	prenyltransferase activity
A1R12_01910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A1R12_01925	COG3104	oligopeptide transport
A1R12_01930	COG5434	Belongs to the glycosyl hydrolase 28 family
A1R12_01940	COG0697	spore germination
A1R12_01950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A1R12_01965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_01970	COG0765	amino acid transport
A1R12_01975	COG1126	abc transporter atp-binding protein
A1R12_01985	COG2079	MmgE PrpD family protein
A1R12_01990	COG1136	(ABC) transporter
A1R12_01995	COG0577	efflux transmembrane transporter activity
A1R12_02000	COG0745	RESPONSE REGULATOR receiver
A1R12_02005	COG3850	Histidine kinase
A1R12_02005	COG5002	protein histidine kinase activity
A1R12_02010	COG0457	Tetratricopeptide repeat
A1R12_02020	COG0527	aspartate kinase activity
A1R12_02025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_02030	COG4605	iron ion homeostasis
A1R12_02035	COG4604	ABC transporter, ATP-binding protein
A1R12_02040	COG4607	ABC-type enterochelin transport system periplasmic component
A1R12_02045	COG2814	Major facilitator Superfamily
A1R12_02050	COG1309	transcriptional regulator
A1R12_02055	COG0778	Nitroreductase
A1R12_02060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A1R12_02065	COG0640	Transcriptional regulator
A1R12_02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_02075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1R12_02080	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_02085	COG4975	Glucose uptake
A1R12_02090	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_02095	COG4549	nuclear export factor GLE1
A1R12_02100	COG1276	copper resistance
A1R12_02100	COG2372	response to copper ion
A1R12_02105	COG1349	DNA-binding transcription factor activity
A1R12_02115	COG2213	PTS system mannitol-specific
A1R12_02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_02130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A1R12_02135	COG0561	phosphatase activity
A1R12_02145	COG1914	H( )-stimulated, divalent metal cation uptake system
A1R12_02155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A1R12_02160	COG1984	allophanate hydrolase subunit 2
A1R12_02165	COG1414	Transcriptional regulator
A1R12_02170	COG2755	lipolytic protein G-D-S-L family
A1R12_02180	COG2329	Antibiotic biosynthesis monooxygenase
A1R12_02185	COG0768	penicillin binding
A1R12_02190	COG4989	oxidoreductase activity
A1R12_02195	COG3711	transcriptional antiterminator
A1R12_02200	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_02205	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_02210	COG1917	Cupin 2, conserved barrel domain protein
A1R12_02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1R12_02220	COG3871	stress protein (general stress protein 26)
A1R12_02230	COG2814	Major facilitator Superfamily
A1R12_02235	COG1522	sequence-specific DNA binding
A1R12_02240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1R12_02240	COG0551	DNA topoisomerase type I activity
A1R12_02245	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A1R12_02250	COG3706	GGDEF domain
A1R12_02255	COG5298	Protein conserved in bacteria
A1R12_02260	COG1215	transferase activity, transferring glycosyl groups
A1R12_02270	COG0531	amino acid
A1R12_02275	COG0494	nUDIX hydrolase
A1R12_02280	COG0028	Belongs to the TPP enzyme family
A1R12_02330	COG1914	H( )-stimulated, divalent metal cation uptake system
A1R12_02340	COG4876	unkown
A1R12_02350	COG2076	Multidrug Resistance protein
A1R12_02355	COG2217	Heavy metal translocating P-type atpase
A1R12_02360	COG3729	General stress protein
A1R12_02365	COG0662	Cupin 2, conserved barrel domain protein
A1R12_02370	COG2329	Antibiotic biosynthesis monooxygenase
A1R12_02375	COG3546	catalase activity
A1R12_02380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A1R12_02385	COG3290	protein histidine kinase activity
A1R12_02390	COG4565	transcriptional regulatory protein
A1R12_02395	COG1301	dicarboxylic acid transport
A1R12_02400	COG0628	permease
A1R12_02405	COG1131	(ABC) transporter
A1R12_02410	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A1R12_02420	COG1960	acyl-CoA dehydrogenase activity
A1R12_02430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A1R12_02435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_02445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A1R12_02450	COG0513	Belongs to the DEAD box helicase family
A1R12_02455	COG3402	PFAM membrane-flanked domain
A1R12_02460	COG3428	Bacterial PH domain
A1R12_02465	COG0705	Rhomboid family
A1R12_02475	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A1R12_02480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1R12_02485	COG0864	Transcriptional regulator
A1R12_02490	COG2337	Toxic component of a toxin-antitoxin (TA) module
A1R12_02495	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_02500	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_02505	COG2172	sigma factor antagonist activity
A1R12_02510	COG2208	phosphoserine phosphatase activity
A1R12_02515	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_02525	COG1191	sigma factor activity
A1R12_02530	COG2208	phosphoserine phosphatase activity
A1R12_02535	COG2183	response to ionizing radiation
A1R12_02580	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1R12_02590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A1R12_02595	COG1522	sequence-specific DNA binding
A1R12_02610	COG0477	Major facilitator Superfamily
A1R12_02635	COG1959	2 iron, 2 sulfur cluster binding
A1R12_02640	COG2910	NAD(P)H-binding
A1R12_02645	COG1278	Cold shock
A1R12_02650	COG1329	Transcriptional regulator
A1R12_02655	COG1794	racemase activity, acting on amino acids and derivatives
A1R12_02670	COG3621	Patatin-like phospholipase
A1R12_02680	COG0662	Cupin 2, conserved barrel domain protein
A1R12_02695	COG0277	FAD linked oxidase domain protein
A1R12_02720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1R12_02755	COG0351	phosphomethylpyrimidine kinase
A1R12_02770	COG1064	alcohol dehydrogenase
A1R12_02775	COG0789	Transcriptional regulator
A1R12_02785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_02800	COG2814	Major facilitator Superfamily
A1R12_02805	COG1309	transcriptional regulator
A1R12_02810	COG0697	spore germination
A1R12_02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_02820	COG5577	PFAM Coat F domain
A1R12_02830	COG1063	alcohol dehydrogenase
A1R12_02835	COG5577	PFAM Coat F domain
A1R12_02850	COG4585	Histidine kinase
A1R12_02855	COG2197	response regulator
A1R12_02860	COG2409	Drug exporters of the RND superfamily
A1R12_02865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A1R12_02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1R12_02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_02890	COG2814	Major facilitator Superfamily
A1R12_02895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1R12_02905	COG0730	response to heat
A1R12_02910	COG0456	acetyltransferase
A1R12_02915	COG0789	Transcriptional regulator
A1R12_02915	COG4978	Transcriptional regulator
A1R12_02920	COG1051	belongs to the nudix hydrolase family
A1R12_02925	COG2226	methyltransferase
A1R12_02930	COG0473	3-isopropylmalate dehydrogenase activity
A1R12_02935	COG1802	Transcriptional regulator
A1R12_02940	COG1819	glycosyl
A1R12_02955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1R12_02960	COG1388	LysM domain
A1R12_02965	COG2814	Major facilitator Superfamily
A1R12_02970	COG2188	Transcriptional regulator
A1R12_02975	COG2186	Transcriptional regulator
A1R12_02980	COG2807	transmembrane transport
A1R12_02985	COG2076	Multidrug Resistance protein
A1R12_02990	COG2076	Multidrug Resistance protein
A1R12_02995	COG1309	transcriptional regulator
A1R12_03000	COG0531	amino acid
A1R12_03010	COG3832	glyoxalase III activity
A1R12_03015	COG0604	alcohol dehydrogenase
A1R12_03020	COG2814	Major facilitator Superfamily
A1R12_03055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A1R12_03060	COG0802	atpase or kinase
A1R12_03065	COG1214	PFAM Peptidase M22, glycoprotease
A1R12_03070	COG0456	acetyltransferase
A1R12_03075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A1R12_03080	COG0488	(ABC) transporter
A1R12_03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1R12_03100	COG0805	protein transport
A1R12_03110	COG1266	CAAX protease self-immunity
A1R12_03115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A1R12_03130	COG0457	Tetratricopeptide repeat
A1R12_03135	COG1063	alcohol dehydrogenase
A1R12_03140	COG2211	Major facilitator Superfamily
A1R12_03145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1R12_03155	COG1842	Phage shock protein A
A1R12_03160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A1R12_03165	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A1R12_03170	COG4260	virion core protein, lumpy skin disease virus
A1R12_03175	COG2755	lipolytic protein G-D-S-L family
A1R12_03175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A1R12_03185	COG1595	DNA-templated transcription, initiation
A1R12_03190	COG1063	alcohol dehydrogenase
A1R12_03195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A1R12_03200	COG0823	Involved in the tonB-independent uptake of proteins
A1R12_03210	COG2132	Multicopper oxidase
A1R12_03215	COG1113	amino acid transport
A1R12_03220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A1R12_03225	COG0714	Associated with various cellular activities
A1R12_03230	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A1R12_03235	COG1305	Transglutaminase-like
A1R12_03260	COG2252	PERMEase
A1R12_03265	COG3064	Membrane
A1R12_03285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A1R12_03290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A1R12_03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A1R12_03300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A1R12_03305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1R12_03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A1R12_03330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A1R12_03335	COG0138	bifunctional purine biosynthesis protein purh
A1R12_03340	COG0151	Belongs to the GarS family
A1R12_03350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A1R12_03355	COG1470	cell adhesion involved in biofilm formation
A1R12_03360	COG4496	protein, YerC YecD
A1R12_03365	COG0069	glutamate synthase activity
A1R12_03380	COG0210	DNA helicase
A1R12_03390	COG4851	CamS sex pheromone cAM373 precursor
A1R12_03395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A1R12_03400	COG1285	pathogenesis
A1R12_03405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1R12_03425	COG1309	transcriptional regulator
A1R12_03430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1R12_03435	COG1597	lipid kinase activity
A1R12_03440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1R12_03450	COG1131	(ABC) transporter
A1R12_03470	COG5444	nuclease activity
A1R12_03495	COG3546	catalase activity
A1R12_03500	COG0454	-acetyltransferase
A1R12_03510	COG2323	membrane
A1R12_03515	COG2329	Antibiotic biosynthesis monooxygenase
A1R12_03520	COG0346	lactoylglutathione lyase activity
A1R12_03525	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_03530	COG0196	riboflavin kinase activity
A1R12_03535	COG0670	Belongs to the BI1 family
A1R12_03545	COG1846	Transcriptional regulator
A1R12_03550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1R12_03560	COG2124	cytochrome p450
A1R12_03560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A1R12_03575	COG1131	(ABC) transporter
A1R12_03585	COG1368	sulfuric ester hydrolase activity
A1R12_03590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A1R12_03595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_03600	COG1442	glycosyl transferase family 8
A1R12_03605	COG1216	Glycosyl transferase, family 2
A1R12_03610	COG1442	glycosyl transferase family 8
A1R12_03615	COG2223	nitrite transmembrane transporter activity
A1R12_03620	COG0531	amino acid
A1R12_03625	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_03630	COG0840	transmembrane signaling receptor activity
A1R12_03635	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_03640	COG0457	Tetratricopeptide repeat
A1R12_03640	COG0463	Glycosyl transferase, family 2
A1R12_03645	COG0488	(ABC) transporter
A1R12_03650	COG0789	Transcriptional regulator
A1R12_03655	COG2814	Major facilitator Superfamily
A1R12_03660	COG0488	(ABC) transporter
A1R12_03665	COG0513	Belongs to the DEAD box helicase family
A1R12_03670	COG0456	acetyltransferase
A1R12_03675	COG2130	NADP-dependent
A1R12_03690	COG3866	Pectate lyase
A1R12_03695	COG0471	metal ion transport
A1R12_03715	COG2972	Histidine kinase
A1R12_03715	COG0745	RESPONSE REGULATOR receiver
A1R12_03720	COG3279	Response regulator of the LytR AlgR family
A1R12_03730	COG3764	Sortase (surface protein transpeptidase)
A1R12_03735	COG3290	protein histidine kinase activity
A1R12_03740	COG4565	transcriptional regulatory protein
A1R12_03745	COG3181	Tripartite tricarboxylate transporter family receptor
A1R12_03750	COG2851	Citrate transporter
A1R12_03755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_03760	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A1R12_03770	COG2258	MOSC domain
A1R12_03780	COG0024	Methionine aminopeptidase
A1R12_03785	COG1263	PTS System
A1R12_03785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_03795	COG1368	sulfuric ester hydrolase activity
A1R12_03805	COG0071	Belongs to the small heat shock protein (HSP20) family
A1R12_03820	COG1263	PTS System
A1R12_03820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_03825	COG0366	Alpha amylase catalytic
A1R12_03830	COG2188	Transcriptional regulator
A1R12_03835	COG0778	Nitroreductase
A1R12_03850	COG0737	Belongs to the 5'-nucleotidase family
A1R12_03855	COG0693	protein deglycase activity
A1R12_03860	COG1609	Transcriptional regulator
A1R12_03865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A1R12_03875	COG2814	Major facilitator Superfamily
A1R12_03885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1R12_03890	COG4980	gas vesicle protein
A1R12_03895	COG1295	ribonuclease BN
A1R12_03900	COG0477	Major facilitator Superfamily
A1R12_03905	COG0387	Pfam Sodium calcium exchanger
A1R12_03915	COG0668	transmembrane transport
A1R12_03920	COG0535	radical SAM domain protein
A1R12_03930	COG0726	polysaccharide deacetylase
A1R12_03935	COG2084	Dehydrogenase
A1R12_03945	COG0598	Magnesium transport protein CorA
A1R12_03950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A1R12_03955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1R12_03965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1R12_03970	COG4637	Psort location Cytoplasmic, score
A1R12_03975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1R12_03980	COG0022	dehydrogenase e1 component
A1R12_03985	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1R12_03990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1R12_03995	COG3284	Transcriptional regulator
A1R12_04005	COG1486	melibiose metabolic process
A1R12_04010	COG1737	Transcriptional regulator
A1R12_04015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_04015	COG1263	PTS System
A1R12_04020	COG1132	(ABC) transporter
A1R12_04025	COG1132	(ABC) transporter
A1R12_04030	COG2259	Doxx family
A1R12_04035	COG2514	catechol 2,3-dioxygenase activity
A1R12_04050	COG1695	Transcriptional regulator
A1R12_04055	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1R12_04060	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A1R12_04065	COG3848	Pyruvate phosphate dikinase
A1R12_04065	COG0574	Belongs to the PEP-utilizing enzyme family
A1R12_04070	COG2732	(Barnase) inhibitor
A1R12_04075	COG2318	DinB family
A1R12_04080	COG2814	Major facilitator Superfamily
A1R12_04085	COG1846	Transcriptional regulator
A1R12_04090	COG0392	lysyltransferase activity
A1R12_04090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A1R12_04095	COG0384	phenazine biosynthesis protein PhzF
A1R12_04100	COG0778	Nitroreductase
A1R12_04110	COG1090	epimerase
A1R12_04125	COG2814	Major facilitator Superfamily
A1R12_04135	COG3591	Belongs to the peptidase S1B family
A1R12_04150	COG3103	Sh3 type 3 domain protein
A1R12_04155	COG5658	integral membrane protein
A1R12_04160	COG0596	Alpha beta hydrolase
A1R12_04165	COG0463	Glycosyl transferase, family 2
A1R12_04170	COG4485	Bacterial membrane protein, YfhO
A1R12_04175	COG1988	membrane-bound metal-dependent
A1R12_04180	COG1194	a g-specific adenine glycosylase
A1R12_04190	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_04210	COG1132	(ABC) transporter
A1R12_04215	COG4129	membrane
A1R12_04225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A1R12_04230	COG0735	belongs to the Fur family
A1R12_04335	COG1757	Na H antiporter
A1R12_04340	COG3340	Belongs to the peptidase S51 family
A1R12_04350	COG0277	FAD linked oxidase domain protein
A1R12_04360	COG0747	negative chemotaxis
A1R12_04365	COG0601	transmembrane transport
A1R12_04370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1R12_04375	COG0444	Belongs to the ABC transporter superfamily
A1R12_04380	COG4608	Belongs to the ABC transporter superfamily
A1R12_04385	COG0753	catalase activity
A1R12_04395	COG1116	anion transmembrane transporter activity
A1R12_04400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1R12_04405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1R12_04425	COG1476	TRANSCRIPTIONal
A1R12_04435	COG3382	B3 4 domain protein
A1R12_04440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A1R12_04450	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A1R12_04455	COG0789	Transcriptional regulator
A1R12_04460	COG1664	Polymer-forming cytoskeletal
A1R12_04465	COG1664	Polymer-forming cytoskeletal
A1R12_04470	COG2766	serine protein kinase
A1R12_04480	COG1846	Transcriptional regulator
A1R12_04485	COG1566	PFAM secretion protein HlyD family protein
A1R12_04490	COG2814	Major facilitator Superfamily
A1R12_04495	COG0655	NAD(P)H dehydrogenase (quinone) activity
A1R12_04510	COG1725	Transcriptional regulator
A1R12_04515	COG1131	(ABC) transporter
A1R12_04520	COG1131	(ABC) transporter
A1R12_04525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A1R12_04530	COG1278	Cold shock
A1R12_04535	COG1464	Belongs to the NlpA lipoprotein family
A1R12_04540	COG3706	GGDEF domain
A1R12_04545	COG1823	symporter activity
A1R12_04565	COG5577	PFAM Coat F domain
A1R12_04570	COG4085	toxin activity
A1R12_04570	COG1525	nuclease
A1R12_04570	COG0737	Belongs to the 5'-nucleotidase family
A1R12_04575	COG3764	Sortase (surface protein transpeptidase)
A1R12_04580	COG0564	pseudouridine synthase activity
A1R12_04590	COG0517	IMP dehydrogenase activity
A1R12_04595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1R12_04600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1R12_04600	COG3153	acetyltransferase
A1R12_04605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A1R12_04610	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A1R12_04615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A1R12_04625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A1R12_04630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1R12_04635	COG4585	Histidine kinase
A1R12_04635	COG2203	Gaf domain
A1R12_04640	COG2197	response regulator
A1R12_04645	COG0431	NADPH-dependent FMN reductase
A1R12_04660	COG0791	NLP P60 protein
A1R12_04660	COG1388	LysM domain
A1R12_04665	COG1959	2 iron, 2 sulfur cluster binding
A1R12_04670	COG0668	transmembrane transport
A1R12_04675	COG2719	SpoVR family
A1R12_04680	COG1785	Belongs to the alkaline phosphatase family
A1R12_04685	COG0791	NLP P60 protein
A1R12_04685	COG1388	LysM domain
A1R12_04690	COG0583	DNA-binding transcription factor activity
A1R12_04695	COG0372	Belongs to the citrate synthase family
A1R12_04700	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_04705	COG0531	amino acid
A1R12_04710	COG0733	neurotransmitter:sodium symporter activity
A1R12_04725	COG1595	DNA-templated transcription, initiation
A1R12_04730	COG0204	Acyl-transferase
A1R12_04735	COG1253	flavin adenine dinucleotide binding
A1R12_04740	COG0789	Transcriptional regulator
A1R12_04745	COG0436	Aminotransferase
A1R12_04750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1R12_04755	COG1253	flavin adenine dinucleotide binding
A1R12_04760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1R12_04765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1R12_04770	COG0584	glycerophosphoryl diester phosphodiesterase
A1R12_04775	COG0668	transmembrane transport
A1R12_04780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A1R12_04785	COG0726	polysaccharide deacetylase
A1R12_04790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1R12_04795	COG3226	Transcriptional regulator
A1R12_04805	COG0589	response to stress
A1R12_04810	COG1132	(ABC) transporter
A1R12_04815	COG1132	(ABC) transporter
A1R12_04820	COG0702	epimerase
A1R12_04835	COG0189	ligase activity
A1R12_04840	COG0189	ligase activity
A1R12_04855	COG4335	DNA alkylation repair
A1R12_04860	COG0561	phosphatase activity
A1R12_04865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1R12_04875	COG0475	glutathione-regulated potassium exporter activity
A1R12_04880	COG0490	domain, Protein
A1R12_04890	COG1024	Enoyl-CoA hydratase
A1R12_04900	COG4152	abc transporter atp-binding protein
A1R12_04905	COG1668	transmembrane transport
A1R12_04910	COG0420	3'-5' exonuclease activity
A1R12_04915	COG4717	serine-type aminopeptidase activity
A1R12_04930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1R12_04960	COG4980	gas vesicle protein
A1R12_04975	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A1R12_04980	COG0537	adenosine 5'-monophosphoramidase activity
A1R12_04985	COG1131	(ABC) transporter
A1R12_04990	COG4473	ABC transporter
A1R12_05000	COG1473	amidohydrolase
A1R12_05005	COG3069	C4-dicarboxylate transmembrane transporter activity
A1R12_05010	COG2329	Antibiotic biosynthesis monooxygenase
A1R12_05015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1R12_05035	COG1309	transcriptional regulator
A1R12_05040	COG1511	domain protein
A1R12_05045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1R12_05055	COG1363	Peptidase, m42
A1R12_05060	COG1301	dicarboxylic acid transport
A1R12_05065	COG1234	tRNA 3'-trailer cleavage
A1R12_05070	COG0095	Lipoate-protein ligase
A1R12_05075	COG0702	epimerase
A1R12_05080	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_05090	COG0501	Belongs to the peptidase M48B family
A1R12_05095	COG1404	Belongs to the peptidase S8 family
A1R12_05105	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A1R12_05110	COG0406	alpha-ribazole phosphatase activity
A1R12_05115	COG0183	Belongs to the thiolase family
A1R12_05120	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_05125	COG1268	BioY protein
A1R12_05130	COG0840	transmembrane signaling receptor activity
A1R12_05135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1R12_05135	COG0723	plastoquinol--plastocyanin reductase activity
A1R12_05140	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_05150	COG4903	ComK protein
A1R12_05160	COG5646	InterPro IPR014922
A1R12_05185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1R12_05200	COG0398	Pfam SNARE associated Golgi protein
A1R12_05205	COG0681	Belongs to the peptidase S26 family
A1R12_05210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1R12_05215	COG1846	Transcriptional regulator
A1R12_05220	COG3180	Ammonia monooxygenase
A1R12_05225	COG2814	Major facilitator Superfamily
A1R12_05235	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A1R12_05255	COG0420	3'-5' exonuclease activity
A1R12_05260	COG0419	ATPase involved in DNA repair
A1R12_05265	COG1403	HNH endonuclease
A1R12_05305	COG0179	Fumarylacetoacetate (FAA) hydrolase
A1R12_05325	COG0367	asparagine synthase
A1R12_05330	COG1562	ergosterol biosynthetic process
A1R12_05335	COG0534	Mate efflux family protein
A1R12_05340	COG1917	Cupin 2, conserved barrel domain protein
A1R12_05340	COG2207	Transcriptional regulator
A1R12_05345	COG2318	DinB family
A1R12_05350	COG1279	arginine transmembrane transporter activity
A1R12_05355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_05360	COG1357	PFAM Pentapeptide repeats (8 copies)
A1R12_05365	COG2153	protein acetylation
A1R12_05370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A1R12_05370	COG0646	methionine synthase
A1R12_05380	COG2996	Protein conserved in bacteria
A1R12_05390	COG0840	transmembrane signaling receptor activity
A1R12_05395	COG2124	cytochrome p450
A1R12_05400	COG1307	EDD domain protein, DegV family
A1R12_05405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_05420	COG0561	phosphatase activity
A1R12_05425	COG1073	alpha beta
A1R12_05430	COG2151	metal-sulfur cluster biosynthetic enzyme
A1R12_05440	COG0277	FAD linked oxidase domain protein
A1R12_05445	COG2271	Major facilitator Superfamily
A1R12_05465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1R12_05470	COG0505	Belongs to the CarA family
A1R12_05475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A1R12_05480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A1R12_05500	COG2267	carboxylic ester hydrolase activity
A1R12_05510	COG1744	ABC transporter substrate-binding protein PnrA-like
A1R12_05525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1R12_05530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1R12_05535	COG5504	Zn-dependent protease
A1R12_05540	COG0444	Belongs to the ABC transporter superfamily
A1R12_05545	COG4608	Belongs to the ABC transporter superfamily
A1R12_05555	COG0601	transmembrane transport
A1R12_05560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1R12_05570	COG0180	Tryptophanyl-tRNA synthetase
A1R12_05575	COG4166	transmembrane transport
A1R12_05580	COG0601	transmembrane transport
A1R12_05585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1R12_05590	COG0444	Belongs to the ABC transporter superfamily
A1R12_05595	COG4608	Belongs to the ABC transporter superfamily
A1R12_05605	COG0456	acetyltransferase
A1R12_05610	COG1393	Belongs to the ArsC family
A1R12_05615	COG0861	Integral membrane protein TerC family
A1R12_05620	COG4862	establishment of competence for transformation
A1R12_05625	COG4469	Competence protein
A1R12_05630	COG1164	Oligoendopeptidase f
A1R12_05640	COG2346	COG2346, Truncated hemoglobins
A1R12_05645	COG0741	lytic transglycosylase activity
A1R12_05650	COG4116	CYTH
A1R12_05660	COG2357	RelA SpoT domain protein
A1R12_05665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A1R12_05670	COG0564	pseudouridine synthase activity
A1R12_05680	COG0569	domain protein
A1R12_05680	COG0475	glutathione-regulated potassium exporter activity
A1R12_05685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A1R12_05690	COG0352	thiamine-phosphate diphosphorylase activity
A1R12_05695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1R12_05700	COG2104	thiamine diphosphate biosynthetic process
A1R12_05710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A1R12_05715	COG0351	phosphomethylpyrimidine kinase
A1R12_05720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A1R12_05775	COG0210	DNA helicase
A1R12_05795	COG1131	(ABC) transporter
A1R12_05805	COG2153	protein acetylation
A1R12_05815	COG2382	esterase
A1R12_05820	COG0626	cystathionine gamma-synthase activity
A1R12_05825	COG0626	cystathionine gamma-synthase activity
A1R12_05895	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_05895	COG5632	N-Acetylmuramoyl-L-alanine amidase
A1R12_05905	COG5444	nuclease activity
A1R12_05930	COG0135	phosphoribosylanthranilate isomerase activity
A1R12_05940	COG2367	Beta-lactamase
A1R12_05945	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A1R12_05955	COG1846	Transcriptional regulator
A1R12_05965	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A1R12_05970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1R12_05975	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A1R12_05980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_05980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_05985	COG1447	Phosphotransferase system cellobiose-specific component IIA
A1R12_06020	COG1285	pathogenesis
A1R12_06030	COG2205	protein histidine kinase activity
A1R12_06040	COG3383	formate dehydrogenase (NAD+) activity
A1R12_06045	COG2427	Protein of unknown function (DUF1641)
A1R12_06050	COG2124	cytochrome p450
A1R12_06055	COG1819	glycosyl
A1R12_06065	COG1587	Uroporphyrinogen-III synthase
A1R12_06070	COG0390	transport system, permease component
A1R12_06075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1R12_06080	COG0697	spore germination
A1R12_06085	COG4297	protein containing double-stranded beta helix domain
A1R12_06095	COG1252	NADH dehydrogenase
A1R12_06105	COG2211	Major facilitator Superfamily
A1R12_06110	COG1609	Transcriptional regulator
A1R12_06115	COG0246	Mannitol dehydrogenase
A1R12_06120	COG2721	sulfolactate sulfo-lyase activity
A1R12_06125	COG0730	response to heat
A1R12_06130	COG2318	DinB family
A1R12_06135	COG0457	Tetratricopeptide repeat
A1R12_06140	COG5632	N-Acetylmuramoyl-L-alanine amidase
A1R12_06140	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_06140	COG1388	LysM domain
A1R12_06150	COG4195	phage-related replication protein
A1R12_06155	COG3546	catalase activity
A1R12_06160	COG2856	Zn peptidase
A1R12_06165	COG1396	sequence-specific DNA binding
A1R12_06175	COG1522	sequence-specific DNA binding
A1R12_06180	COG1484	DNA-dependent DNA replication
A1R12_06195	COG1595	DNA-templated transcription, initiation
A1R12_06200	COG3728	DNA packaging
A1R12_06200	COG5484	DNA packaging
A1R12_06205	COG1783	phage Terminase large subunit
A1R12_06210	COG5518	Phage portal protein
A1R12_06215	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A1R12_06220	COG4653	Phage capsid family
A1R12_06265	COG3953	SLT domain
A1R12_06265	COG3953	SLT domain
A1R12_06265	COG5412	phage tail tape measure protein
A1R12_06265	COG5412	phage tail tape measure protein
A1R12_06265	COG5412	phage tail tape measure protein
A1R12_06265	COG3953	SLT domain
A1R12_06270	COG1652	LysM domain
A1R12_06275	COG4193	domain, Protein
A1R12_06285	COG3628	GPW Gp25 family protein
A1R12_06290	COG3299	homolog of phage Mu protein gp47
A1R12_06295	COG3778	Protein conserved in bacteria
A1R12_06335	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_06335	COG5632	N-Acetylmuramoyl-L-alanine amidase
A1R12_06350	COG0306	phosphate transporter
A1R12_06355	COG1392	Phosphate transport regulator
A1R12_06360	COG0531	amino acid
A1R12_06365	COG0346	lactoylglutathione lyase activity
A1R12_06370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A1R12_06375	COG0463	Glycosyl transferase, family 2
A1R12_06380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1R12_06385	COG0477	Major facilitator Superfamily
A1R12_06390	COG2362	D-Aminopeptidase
A1R12_06395	COG0601	transmembrane transport
A1R12_06400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1R12_06405	COG0444	Belongs to the ABC transporter superfamily
A1R12_06410	COG4166	transmembrane transport
A1R12_06415	COG1619	proteins homologs of microcin C7 resistance protein MccF
A1R12_06420	COG4948	Mandelate Racemase Muconate Lactonizing
A1R12_06425	COG0791	NLP P60 protein
A1R12_06430	COG4608	Belongs to the ABC transporter superfamily
A1R12_06435	COG2706	6-phosphogluconolactonase activity
A1R12_06440	COG1834	amidinotransferase
A1R12_06445	COG1607	acyl-coa hydrolase
A1R12_06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1R12_06455	COG2076	Multidrug Resistance protein
A1R12_06460	COG2076	Multidrug Resistance protein
A1R12_06465	COG0788	formyltetrahydrofolate deformylase activity
A1R12_06470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A1R12_06480	COG1764	response to oxidative stress
A1R12_06485	COG1846	Transcriptional regulator
A1R12_06490	COG1764	response to oxidative stress
A1R12_06505	COG0463	Glycosyl transferase, family 2
A1R12_06505	COG0457	Tetratricopeptide repeat
A1R12_06515	COG2814	Major facilitator Superfamily
A1R12_06520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1R12_06530	COG1404	Belongs to the peptidase S8 family
A1R12_06535	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_06540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A1R12_06545	COG1122	ATPase activity
A1R12_06550	COG4721	ABC-type cobalt transport system, permease component
A1R12_06555	COG3858	chitin binding
A1R12_06555	COG1388	LysM domain
A1R12_06560	COG2239	Acts as a magnesium transporter
A1R12_06565	COG0789	Transcriptional regulator
A1R12_06575	COG1846	Transcriptional regulator
A1R12_06580	COG0726	polysaccharide deacetylase
A1R12_06585	COG1793	dna ligase
A1R12_06585	COG3285	dna ligase
A1R12_06590	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A1R12_06595	COG0586	Pfam SNARE associated Golgi protein
A1R12_06600	COG0861	Integral membrane protein TerC family
A1R12_06605	COG1191	sigma factor activity
A1R12_06630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A1R12_06635	COG2323	membrane
A1R12_06640	COG3594	Acyltransferase
A1R12_06645	COG5002	protein histidine kinase activity
A1R12_06650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1R12_06665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1R12_06670	COG0436	Aminotransferase
A1R12_06700	COG3852	Histidine kinase
A1R12_06705	COG1846	Transcriptional regulator
A1R12_06710	COG1360	Flagellar Motor Protein
A1R12_06715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A1R12_06720	COG0542	response to heat
A1R12_06725	COG3949	Membrane
A1R12_06740	COG0720	synthase
A1R12_06745	COG0602	queuosine metabolic process
A1R12_06755	COG1733	regulation of RNA biosynthetic process
A1R12_06760	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_06775	COG4873	Protein conserved in bacteria
A1R12_06785	COG3773	Cell wall hydrolase
A1R12_06790	COG2244	polysaccharide biosynthetic process
A1R12_06795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_06800	COG2217	Heavy metal translocating P-type atpase
A1R12_06805	COG0006	proline dipeptidase activity
A1R12_06810	COG1609	Transcriptional regulator
A1R12_06815	COG3711	transcriptional antiterminator
A1R12_06820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_06820	COG1263	PTS System
A1R12_06820	COG2190	(PTS) system
A1R12_06825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_06830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1R12_06840	COG1533	DNA photolyase activity
A1R12_06845	COG0840	transmembrane signaling receptor activity
A1R12_06850	COG2084	Dehydrogenase
A1R12_06855	COG2340	Cysteine-rich secretory protein family
A1R12_06860	COG0768	penicillin binding
A1R12_06865	COG4191	Histidine kinase
A1R12_06870	COG0436	Aminotransferase
A1R12_06875	COG0835	chemotaxis
A1R12_06875	COG0784	Response regulator, receiver
A1R12_06885	COG2814	Major facilitator Superfamily
A1R12_06890	COG1376	ErfK ybiS ycfS ynhG family protein
A1R12_06895	COG1408	metallophosphoesterase
A1R12_06900	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_06910	COG2200	EAL domain
A1R12_06915	COG4703	Protein of unknown function (DUF1797)
A1R12_06920	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A1R12_06930	COG0517	IMP dehydrogenase activity
A1R12_06935	COG0583	DNA-binding transcription factor activity
A1R12_06940	COG0716	FMN binding
A1R12_06950	COG0716	FMN binding
A1R12_06970	COG0668	transmembrane transport
A1R12_06975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_06995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A1R12_07000	COG0303	'Molybdopterin
A1R12_07005	COG1763	Mo-molybdopterin cofactor biosynthetic process
A1R12_07010	COG0314	molybdopterin synthase activity
A1R12_07015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A1R12_07025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1R12_07030	COG1136	(ABC) transporter
A1R12_07035	COG0577	efflux transmembrane transporter activity
A1R12_07040	COG1349	DNA-binding transcription factor activity
A1R12_07045	COG1105	Belongs to the carbohydrate kinase PfkB family
A1R12_07050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1R12_07050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_07050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1R12_07055	COG0681	Belongs to the peptidase S26 family
A1R12_07065	COG0488	(ABC) transporter
A1R12_07070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A1R12_07075	COG2309	aminopeptidase activity
A1R12_07080	COG1077	Cell shape determining protein MreB Mrl
A1R12_07090	COG2002	toxin-antitoxin pair type II binding
A1R12_07095	COG3852	Histidine kinase
A1R12_07100	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A1R12_07100	COG2105	PFAM AIG2 family protein
A1R12_07105	COG0569	domain protein
A1R12_07115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A1R12_07125	COG0561	phosphatase activity
A1R12_07130	COG0242	peptide deformylase activity
A1R12_07140	COG0497	DNA recombination
A1R12_07155	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_07155	COG3321	synthase
A1R12_07155	COG4221	oxidoreductase activity
A1R12_07155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_07160	COG4221	oxidoreductase activity
A1R12_07160	COG3321	synthase
A1R12_07160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_07160	COG0300	oxidoreductase activity
A1R12_07165	COG4221	oxidoreductase activity
A1R12_07165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_07165	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_07165	COG3321	synthase
A1R12_07170	COG3321	synthase
A1R12_07170	COG0300	oxidoreductase activity
A1R12_07170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_07170	COG4221	oxidoreductase activity
A1R12_07175	COG0300	oxidoreductase activity
A1R12_07175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_07175	COG4221	oxidoreductase activity
A1R12_07175	COG3321	synthase
A1R12_07180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_07180	COG3321	synthase
A1R12_07180	COG4221	oxidoreductase activity
A1R12_07180	COG0300	oxidoreductase activity
A1R12_07185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_07185	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_07185	COG3321	synthase
A1R12_07185	COG4221	oxidoreductase activity
A1R12_07190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1R12_07195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1R12_07200	COG0022	dehydrogenase e1 component
A1R12_07205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1R12_07210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1R12_07215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_07225	COG1982	Orn Lys Arg decarboxylase major
A1R12_07245	COG0483	inositol monophosphate 1-phosphatase activity
A1R12_07255	COG3227	Zinc metalloprotease (Elastase)
A1R12_07270	COG1595	DNA-templated transcription, initiation
A1R12_07300	COG4896	Protein conserved in bacteria
A1R12_07310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A1R12_07315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A1R12_07320	COG2066	Belongs to the glutaminase family
A1R12_07330	COG0772	Belongs to the SEDS family
A1R12_07335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A1R12_07350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1R12_07350	COG2010	Cytochrome c
A1R12_07355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1R12_07360	COG1845	cytochrome c oxidase, subunit III
A1R12_07365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A1R12_07370	COG3336	cytochrome c oxidase
A1R12_07380	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A1R12_07385	COG2340	Cysteine-rich secretory protein family
A1R12_07400	COG3679	Belongs to the UPF0342 family
A1R12_07410	COG0742	ribosomal rna small subunit methyltransferase
A1R12_07420	COG3314	Sporulation integral membrane protein YlbJ
A1R12_07425	COG1752	Esterase of the alpha-beta hydrolase superfamily
A1R12_07430	COG3480	Lon protease (S16) C-terminal proteolytic domain
A1R12_07440	COG1399	metal-binding, possibly nucleic acid-binding protein
A1R12_07455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A1R12_07475	COG4839	cell division protein FtsL
A1R12_07485	COG0768	penicillin binding
A1R12_07505	COG0772	Belongs to the SEDS family
A1R12_07520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A1R12_07525	COG0849	cell division
A1R12_07530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1R12_07535	COG4412	M6 family metalloprotease domain protein
A1R12_07535	COG1404	Belongs to the peptidase S8 family
A1R12_07545	COG1191	sigma factor activity
A1R12_07550	COG1191	sigma factor activity
A1R12_07555	COG1119	ATPase activity
A1R12_07560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1R12_07565	COG1873	PFAM PRC-barrel domain
A1R12_07575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A1R12_07585	COG0762	integral membrane protein
A1R12_07590	COG2302	S4 RNA-binding domain
A1R12_07595	COG3599	regulation of cell shape
A1R12_07605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A1R12_07610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1R12_07620	COG0564	pseudouridine synthase activity
A1R12_07630	COG2233	PERMEase
A1R12_07640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A1R12_07645	COG0505	Belongs to the CarA family
A1R12_07650	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A1R12_07665	COG0284	orotidine-5'-phosphate decarboxylase activity
A1R12_07670	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A1R12_07680	COG0306	phosphate transporter
A1R12_07695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A1R12_07700	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
A1R12_07705	COG1648	precorrin-2 dehydrogenase activity
A1R12_07715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A1R12_07720	COG1561	YicC-like family, N-terminal region
A1R12_07725	COG2052	Domain of unknown function (DUF370)
A1R12_07730	COG0194	GDP metabolic process
A1R12_07740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A1R12_07745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A1R12_07750	COG0242	peptide deformylase activity
A1R12_07760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A1R12_07760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A1R12_07770	COG0631	protein serine/threonine phosphatase activity
A1R12_07775	COG0515	serine threonine protein kinase
A1R12_07775	COG2815	serine threonine protein kinase
A1R12_07785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A1R12_07790	COG1564	THIamine pyrophosphokinase
A1R12_07805	COG1302	Protein conserved in bacteria
A1R12_07810	COG1461	Dihydroxyacetone kinase
A1R12_07815	COG1760	l-serine dehydratase
A1R12_07820	COG1760	l-serine dehydratase
A1R12_07825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A1R12_07840	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A1R12_07845	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_07850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_07860	COG1196	nuclear chromosome segregation
A1R12_07865	COG0552	protein localization to endoplasmic reticulum
A1R12_07880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A1R12_07890	COG1837	Belongs to the UPF0109 family
A1R12_07915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A1R12_07930	COG2257	FlhB HrpN YscU SpaS Family
A1R12_07940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1R12_07945	COG0758	DNA mediated transformation
A1R12_07950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1R12_07960	COG4974	Belongs to the 'phage' integrase family
A1R12_07980	COG1815	bacterial-type flagellum-dependent cell motility
A1R12_07985	COG1558	bacterial-type flagellum-dependent cell motility
A1R12_07990	COG1677	Flagellar hook-basal body complex protein FliE
A1R12_07995	COG1766	The M ring may be actively involved in energy transduction
A1R12_08000	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1R12_08005	COG1317	bacterial-type flagellum organization
A1R12_08010	COG1157	protein secretion by the type III secretion system
A1R12_08015	COG2882	bacterial-type flagellum organization
A1R12_08020	COG3334	PFAM MgtE intracellular
A1R12_08025	COG3144	bacterial-type flagellum assembly
A1R12_08030	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A1R12_08035	COG4786	Flagellar basal body rod
A1R12_08040	COG1582	Flagellar protein (FlbD)
A1R12_08045	COG1580	Controls the rotational direction of flagella during chemotaxis
A1R12_08050	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1R12_08055	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1R12_08055	COG1776	CheC inhibitor of MCP methylation
A1R12_08060	COG2201	protein-glutamate methylesterase activity
A1R12_08065	COG3190	flagellar
A1R12_08070	COG1338	Plays a role in the flagellum-specific transport system
A1R12_08075	COG1987	bacterial-type flagellum assembly
A1R12_08080	COG1684	flagellar biosynthetic protein fliR
A1R12_08085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A1R12_08090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A1R12_08095	COG1419	protein localization to endoplasmic reticulum
A1R12_08100	COG0455	bacterial-type flagellum organization
A1R12_08105	COG2201	protein-glutamate methylesterase activity
A1R12_08110	COG0643	Histidine kinase
A1R12_08110	COG2198	Histidine kinase
A1R12_08115	COG0835	chemotaxis
A1R12_08120	COG1776	CheC inhibitor of MCP methylation
A1R12_08130	COG1191	sigma factor activity
A1R12_08160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A1R12_08165	COG4589	Belongs to the CDS family
A1R12_08175	COG0750	zinc metalloprotease
A1R12_08185	COG2176	DNA-directed DNA polymerase activity
A1R12_08195	COG0195	Participates in both transcription termination and antitermination
A1R12_08200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A1R12_08205	COG1358	cellular component organization or biogenesis
A1R12_08215	COG1550	Protein conserved in bacteria
A1R12_08230	COG0196	riboflavin kinase activity
A1R12_08245	COG0726	polysaccharide deacetylase
A1R12_08250	COG0612	Peptidase, M16
A1R12_08255	COG1873	PFAM PRC-barrel domain
A1R12_08260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A1R12_08265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A1R12_08270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A1R12_08275	COG0527	aspartate kinase activity
A1R12_08285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A1R12_08290	COG0740	serine-type endopeptidase activity
A1R12_08300	COG4980	gas vesicle protein
A1R12_08300	COG1674	ftsk spoiiie
A1R12_08305	COG2188	Transcriptional regulator
A1R12_08310	COG2814	Major facilitator Superfamily
A1R12_08315	COG1846	Transcriptional regulator
A1R12_08320	COG1033	growth of symbiont in host cell
A1R12_08320	COG2409	Drug exporters of the RND superfamily
A1R12_08325	COG0612	Peptidase, M16
A1R12_08330	COG0612	Peptidase, M16
A1R12_08335	COG0300	oxidoreductase activity
A1R12_08350	COG1426	Protein conserved in bacteria
A1R12_08355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1R12_08370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1R12_08380	COG1692	metallophosphoesterase
A1R12_08385	COG2359	stage V sporulation protein S
A1R12_08405	COG4550	Control of competence regulator ComK, YlbF/YmcA
A1R12_08425	COG0582	viral genome integration into host DNA
A1R12_08445	COG2801	Transposase and inactivated derivatives
A1R12_08480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_08485	COG3425	synthase
A1R12_08490	COG1024	Enoyl-CoA hydratase
A1R12_08495	COG1024	Enoyl-CoA hydratase
A1R12_08500	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_08500	COG0300	oxidoreductase activity
A1R12_08500	COG3321	synthase
A1R12_08500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_08500	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_08505	COG4221	oxidoreductase activity
A1R12_08505	COG0300	oxidoreductase activity
A1R12_08505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_08505	COG3321	synthase
A1R12_08510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_08510	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_08510	COG3321	synthase
A1R12_08510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_08510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_08510	COG3321	synthase
A1R12_08510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_08510	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_08515	COG4221	oxidoreductase activity
A1R12_08515	COG3321	synthase
A1R12_08515	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_08515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_08520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A1R12_08520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A1R12_08520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_08520	COG3321	synthase
A1R12_08525	COG2124	cytochrome p450
A1R12_08530	COG3209	COG3209 Rhs family protein
A1R12_08535	COG3619	membrane
A1R12_08545	COG1404	Belongs to the peptidase S8 family
A1R12_08555	COG4195	phage-related replication protein
A1R12_08560	COG1764	response to oxidative stress
A1R12_08570	COG2076	Multidrug Resistance protein
A1R12_08610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1R12_08615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1R12_08620	COG4112	unkown
A1R12_08625	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_08635	COG0464	growth
A1R12_08640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A1R12_08645	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A1R12_08650	COG0789	Transcriptional regulator
A1R12_08655	COG0174	glutamine synthetase
A1R12_08680	COG2211	Major facilitator Superfamily
A1R12_08685	COG3507	Belongs to the glycosyl hydrolase 43 family
A1R12_08700	COG1070	Carbohydrate kinase
A1R12_08705	COG3848	Pyruvate phosphate dikinase
A1R12_08705	COG0574	Belongs to the PEP-utilizing enzyme family
A1R12_08725	COG1064	alcohol dehydrogenase
A1R12_08735	COG0456	acetyltransferase
A1R12_08755	COG3397	chitin binding
A1R12_08760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1R12_08770	COG5434	Belongs to the glycosyl hydrolase 28 family
A1R12_08775	COG0756	dUTP diphosphatase activity
A1R12_08780	COG4195	phage-related replication protein
A1R12_08810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1R12_08820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A1R12_08840	COG0785	Cytochrome C biogenesis protein
A1R12_08845	COG2201	protein-glutamate methylesterase activity
A1R12_08850	COG4846	Membrane protein involved in cytochrome C biogenesis
A1R12_08860	COG0071	Belongs to the small heat shock protein (HSP20) family
A1R12_08875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1R12_08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_08900	COG0824	Thioesterase
A1R12_08910	COG4841	protein insertion into membrane
A1R12_08920	COG1832	CoA-binding protein
A1R12_08925	COG0187	DNA topoisomerase II activity
A1R12_08930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1R12_08940	COG1115	amino acid carrier protein
A1R12_08950	COG1063	alcohol dehydrogenase
A1R12_08955	COG0800	Aldolase
A1R12_08960	COG1312	Catalyzes the dehydration of D-mannonate
A1R12_08965	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_08970	COG1609	Transcriptional regulator
A1R12_08975	COG2271	Major facilitator Superfamily
A1R12_09010	COG0457	Tetratricopeptide repeat
A1R12_09035	COG1136	(ABC) transporter
A1R12_09035	COG0577	efflux transmembrane transporter activity
A1R12_09065	COG2205	protein histidine kinase activity
A1R12_09070	COG0745	RESPONSE REGULATOR receiver
A1R12_09080	COG3507	Belongs to the glycosyl hydrolase 43 family
A1R12_09110	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_09115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A1R12_09120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A1R12_09125	COG2610	gluconate transmembrane transporter activity
A1R12_09130	COG2124	cytochrome p450
A1R12_09135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A1R12_09150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A1R12_09160	COG2246	polysaccharide biosynthetic process
A1R12_09165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A1R12_09170	COG0586	Pfam SNARE associated Golgi protein
A1R12_09175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1R12_09180	COG1024	Enoyl-CoA hydratase
A1R12_09185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1R12_09190	COG0511	ligase activity, forming carbon-carbon bonds
A1R12_09195	COG0439	Biotin carboxylase
A1R12_09200	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_09205	COG1960	acyl-CoA dehydrogenase activity
A1R12_09210	COG1649	PFAM Uncharacterised BCR, COG1649
A1R12_09220	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A1R12_09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_09230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_09240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_09245	COG2027	D-alanyl-D-alanine carboxypeptidase
A1R12_09250	COG2017	converts alpha-aldose to the beta-anomer
A1R12_09255	COG0534	Mate efflux family protein
A1R12_09270	COG0582	viral genome integration into host DNA
A1R12_09275	COG0166	Belongs to the GPI family
A1R12_09280	COG0405	Gamma-glutamyltransferase
A1R12_09285	COG2814	Major facilitator Superfamily
A1R12_09290	COG0640	Transcriptional regulator
A1R12_09295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A1R12_09305	COG0604	alcohol dehydrogenase
A1R12_09310	COG0493	'glutamate synthase
A1R12_09315	COG0070	glutamate synthase
A1R12_09315	COG0069	glutamate synthase activity
A1R12_09315	COG0067	glutamate synthase
A1R12_09320	COG0583	DNA-binding transcription factor activity
A1R12_09325	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A1R12_09340	COG0300	oxidoreductase activity
A1R12_09345	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A1R12_09355	COG2814	Major facilitator Superfamily
A1R12_09360	COG1070	Carbohydrate kinase
A1R12_09365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1R12_09370	COG0243	molybdopterin cofactor binding
A1R12_09400	COG5444	nuclease activity
A1R12_09405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1R12_09410	COG2207	Transcriptional regulator
A1R12_09410	COG0662	Cupin 2, conserved barrel domain protein
A1R12_09415	COG1309	transcriptional regulator
A1R12_09420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_09430	COG0640	Transcriptional regulator
A1R12_09435	COG0741	lytic transglycosylase activity
A1R12_09440	COG2322	membrane
A1R12_09455	COG1619	proteins homologs of microcin C7 resistance protein MccF
A1R12_09465	COG1388	LysM domain
A1R12_09465	COG3584	3D domain protein
A1R12_09470	COG0514	ATP-dependent DNA helicase (RecQ)
A1R12_09480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A1R12_09485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1R12_09500	COG0071	Belongs to the small heat shock protein (HSP20) family
A1R12_09525	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_09530	COG1657	PFAM Prenyltransferase squalene oxidase
A1R12_09535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1R12_09540	COG0733	neurotransmitter:sodium symporter activity
A1R12_09545	COG0385	Bile acid
A1R12_09550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_09555	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1R12_09565	COG4548	von Willebrand factor, type A
A1R12_09570	COG0714	Associated with various cellular activities
A1R12_09575	COG2032	superoxide dismutase activity
A1R12_09580	COG0791	NLP P60 protein
A1R12_09580	COG1388	LysM domain
A1R12_09585	COG1819	glycosyl
A1R12_09590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A1R12_09595	COG0534	Mate efflux family protein
A1R12_09600	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_09605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1R12_09610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1R12_09620	COG2962	Rard protein
A1R12_09635	COG1942	4-Oxalocrotonate Tautomerase
A1R12_09645	COG1733	regulation of RNA biosynthetic process
A1R12_09650	COG0778	Nitroreductase
A1R12_09655	COG0400	carboxylic ester hydrolase activity
A1R12_09660	COG0346	lactoylglutathione lyase activity
A1R12_09670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1R12_09680	COG2723	6-phospho-beta-galactosidase activity
A1R12_09685	COG2188	Transcriptional regulator
A1R12_09690	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_09690	COG0793	Belongs to the peptidase S41A family
A1R12_09695	COG2226	methyltransferase
A1R12_09705	COG1876	peptidase activity
A1R12_09720	COG0671	phosphoesterase, PA-phosphatase related
A1R12_09745	COG1509	lysine 2,3-aminomutase activity
A1R12_09750	COG0456	acetyltransferase
A1R12_09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1R12_09760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A1R12_09765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A1R12_09770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A1R12_09775	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A1R12_09785	COG0456	acetyltransferase
A1R12_09790	COG0463	Glycosyl transferase, family 2
A1R12_09805	COG4641	Protein conserved in bacteria
A1R12_09815	COG1086	Polysaccharide biosynthesis protein
A1R12_09830	COG1388	LysM domain
A1R12_09835	COG0457	Tetratricopeptide repeat
A1R12_09845	COG3391	amine dehydrogenase activity
A1R12_09865	COG5444	nuclease activity
A1R12_09870	COG4282	regulation of fungal-type cell wall biogenesis
A1R12_09875	COG1525	nuclease
A1R12_09880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1R12_09900	COG1846	Transcriptional regulator
A1R12_09905	COG4698	Protein conserved in bacteria
A1R12_09910	COG2755	lipolytic protein G-D-S-L family
A1R12_09915	COG1999	signal sequence binding
A1R12_09925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1R12_09930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A1R12_09935	COG1272	protein, Hemolysin III
A1R12_09940	COG0204	Acyl-transferase
A1R12_09945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A1R12_09960	COG2136	Putative SAM-dependent methyltransferase
A1R12_09960	COG2521	methyltransferase
A1R12_09975	COG1413	lyase activity
A1R12_09980	COG1418	mRNA catabolic process
A1R12_09985	COG0386	Belongs to the glutathione peroxidase family
A1R12_09995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1R12_10000	COG1278	Cold shock
A1R12_10020	COG0328	RNA-DNA hybrid ribonuclease activity
A1R12_10025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A1R12_10030	COG0328	RNA-DNA hybrid ribonuclease activity
A1R12_10040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1R12_10050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A1R12_10055	COG1755	Isoprenylcysteine carboxyl methyltransferase
A1R12_10060	COG3424	synthase
A1R12_10085	COG1335	isochorismatase
A1R12_10120	COG5632	N-Acetylmuramoyl-L-alanine amidase
A1R12_10125	COG4824	toxin secretion phage lysis holin
A1R12_10145	COG5434	Belongs to the glycosyl hydrolase 28 family
A1R12_10150	COG1705	Flagellar rod assembly protein muramidase FlgJ
A1R12_10160	COG3953	SLT domain
A1R12_10160	COG5280	Phage tail tape measure protein TP901
A1R12_10245	COG1595	DNA-templated transcription, initiation
A1R12_10270	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1R12_10275	COG1484	DNA-dependent DNA replication
A1R12_10280	COG3935	DnaD domain protein
A1R12_10320	COG3646	Phage regulatory protein
A1R12_10320	COG3645	SOS response
A1R12_10330	COG3620	sequence-specific DNA binding
A1R12_10335	COG0582	viral genome integration into host DNA
A1R12_10340	COG2233	PERMEase
A1R12_10350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A1R12_10355	COG1199	ATP-dependent helicase activity
A1R12_10365	COG0116	Belongs to the methyltransferase superfamily
A1R12_10385	COG3359	exonuclease
A1R12_10390	COG1111	helicase
A1R12_10390	COG1205	dead DEAH box helicase
A1R12_10395	COG2190	(PTS) system
A1R12_10400	COG0071	Belongs to the small heat shock protein (HSP20) family
A1R12_10440	COG4499	WXG100 protein secretion system (Wss), protein YukC
A1R12_10440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1R12_10450	COG2801	Transposase and inactivated derivatives
A1R12_10460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A1R12_10465	COG3935	DnaD domain protein
A1R12_10475	COG0436	Aminotransferase
A1R12_10480	COG5353	protein conserved in bacteria
A1R12_10485	COG1199	ATP-dependent helicase activity
A1R12_10485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1R12_10515	COG0438	transferase activity, transferring glycosyl groups
A1R12_10520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1R12_10535	COG1694	Mazg nucleotide pyrophosphohydrolase
A1R12_10540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_10545	COG2140	Oxalate decarboxylase
A1R12_10555	COG4347	Protein of unknown function (DUF1405)
A1R12_10560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A1R12_10560	COG2010	Cytochrome c
A1R12_10565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A1R12_10570	COG0723	plastoquinol--plastocyanin reductase activity
A1R12_10585	COG0457	Tetratricopeptide repeat
A1R12_10595	COG0287	Prephenate dehydrogenase
A1R12_10630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1R12_10635	COG4401	Chorismate mutase type I
A1R12_10650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A1R12_10655	COG0105	UTP biosynthetic process
A1R12_10660	COG0142	geranyltranstransferase activity
A1R12_10670	COG0142	geranyltranstransferase activity
A1R12_10685	COG0776	regulation of translation
A1R12_10690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A1R12_10725	COG0539	negative regulation of cytoplasmic translation
A1R12_10735	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A1R12_10740	COG2959	enzyme of heme biosynthesis
A1R12_10745	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_10745	COG3773	Cell wall hydrolase
A1R12_10750	COG2339	peptidase activity
A1R12_10755	COG0492	ferredoxin-NADP+ reductase activity
A1R12_10760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1R12_10765	COG4862	establishment of competence for transformation
A1R12_10770	COG1408	metallophosphoesterase
A1R12_10780	COG1388	LysM domain
A1R12_10785	COG1266	CAAX protease self-immunity
A1R12_10790	COG0514	ATP-dependent DNA helicase (RecQ)
A1R12_10795	COG4955	Helix-turn-helix domain
A1R12_10800	COG1141	Ferredoxin
A1R12_10805	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A1R12_10810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1R12_10820	COG1595	DNA-templated transcription, initiation
A1R12_10825	COG5002	protein histidine kinase activity
A1R12_10830	COG0745	RESPONSE REGULATOR receiver
A1R12_10835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1R12_10840	COG1333	cytochrome c biogenesis protein
A1R12_10845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_10850	COG1187	pseudouridine synthase activity
A1R12_10855	COG0700	Nucleoside recognition
A1R12_10860	COG2715	membrane protein required for spore maturation
A1R12_10865	COG1686	Belongs to the peptidase S11 family
A1R12_10885	COG1547	Domain of unknown function (DUF309)
A1R12_10890	COG0456	acetyltransferase
A1R12_10905	COG0307	riboflavin synthase, alpha
A1R12_10910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1R12_10910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1R12_10920	COG0681	Belongs to the peptidase S26 family
A1R12_10930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1R12_10935	COG4086	secreted protein
A1R12_10940	COG0019	diaminopimelate decarboxylase activity
A1R12_10945	COG0697	spore germination
A1R12_10960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1R12_10980	COG1191	sigma factor activity
A1R12_10990	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_10995	COG1686	Belongs to the peptidase S11 family
A1R12_11000	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A1R12_11005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A1R12_11010	COG4974	Belongs to the 'phage' integrase family
A1R12_11020	COG0735	belongs to the Fur family
A1R12_11025	COG1300	Membrane
A1R12_11040	COG0281	malic enzyme
A1R12_11045	COG1757	Na H antiporter
A1R12_11050	COG1027	Aspartate ammonia-lyase
A1R12_11055	COG0252	asparaginase activity
A1R12_11060	COG1396	sequence-specific DNA binding
A1R12_11065	COG1379	DNA repair
A1R12_11070	COG0494	nUDIX hydrolase
A1R12_11080	COG0667	Aldo Keto reductase
A1R12_11090	COG1073	alpha beta
A1R12_11100	COG4918	Iron-sulphur cluster biosynthesis
A1R12_11105	COG0456	acetyltransferase
A1R12_11105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A1R12_11110	COG2329	Antibiotic biosynthesis monooxygenase
A1R12_11115	COG0456	acetyltransferase
A1R12_11120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1R12_11135	COG0628	permease
A1R12_11140	COG0346	lactoylglutathione lyase activity
A1R12_11150	COG3048	D-serine ammonia-lyase activity
A1R12_11155	COG0300	oxidoreductase activity
A1R12_11160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_11165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A1R12_11170	COG1024	Enoyl-CoA hydratase
A1R12_11175	COG3425	synthase
A1R12_11180	COG2124	cytochrome p450
A1R12_11185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11185	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11185	COG3321	synthase
A1R12_11185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_11190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_11190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11190	COG3321	synthase
A1R12_11190	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_11195	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11195	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_11195	COG0300	oxidoreductase activity
A1R12_11195	COG3321	synthase
A1R12_11200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11200	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11200	COG3321	synthase
A1R12_11200	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_11200	COG0300	oxidoreductase activity
A1R12_11210	COG3321	synthase
A1R12_11210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_11210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1R12_11210	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11215	COG3321	synthase
A1R12_11215	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_11215	COG0300	oxidoreductase activity
A1R12_11215	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_11225	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_11230	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_11245	COG2070	2-Nitropropane dioxygenase
A1R12_11245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A1R12_11250	COG0250	Participates in transcription elongation, termination and antitermination
A1R12_11265	COG0596	Alpha beta hydrolase
A1R12_11280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A1R12_11285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A1R12_11300	COG0706	membrane insertase activity
A1R12_11305	COG2195	Cleaves the N-terminal amino acid of tripeptides
A1R12_11310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1R12_11315	COG0346	lactoylglutathione lyase activity
A1R12_11320	COG1376	ErfK ybiS ycfS ynhG family protein
A1R12_11325	COG4129	membrane
A1R12_11330	COG1126	abc transporter atp-binding protein
A1R12_11335	COG0765	amino acid transport
A1R12_11340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_11350	COG1597	lipid kinase activity
A1R12_11355	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1R12_11360	COG0022	dehydrogenase e1 component
A1R12_11365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1R12_11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1R12_11375	COG3426	butyrate kinase activity
A1R12_11380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1R12_11385	COG0280	phosphate acetyltransferase
A1R12_11390	COG3829	transcription factor binding
A1R12_11390	COG3290	protein histidine kinase activity
A1R12_11400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A1R12_11405	COG2079	MmgE PrpD family protein
A1R12_11410	COG0372	Belongs to the citrate synthase family
A1R12_11415	COG1960	acyl-CoA dehydrogenase activity
A1R12_11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1R12_11425	COG0183	Belongs to the thiolase family
A1R12_11430	COG0584	glycerophosphoryl diester phosphodiesterase
A1R12_11435	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_11460	COG1902	pentaerythritol trinitrate reductase activity
A1R12_11475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1R12_11480	COG0745	RESPONSE REGULATOR receiver
A1R12_11485	COG0750	zinc metalloprotease
A1R12_11490	COG0497	DNA recombination
A1R12_11500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A1R12_11510	COG0142	geranyltranstransferase activity
A1R12_11520	COG1570	exodeoxyribonuclease VII activity
A1R12_11535	COG1302	Protein conserved in bacteria
A1R12_11540	COG0439	Biotin carboxylase
A1R12_11545	COG0511	ligase activity, forming carbon-carbon bonds
A1R12_11585	COG3854	ATPases associated with a variety of cellular activities
A1R12_11600	COG0006	proline dipeptidase activity
A1R12_11610	COG3872	metal-dependent enzyme
A1R12_11620	COG1752	Esterase of the alpha-beta hydrolase superfamily
A1R12_11635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A1R12_11655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A1R12_11670	COG1396	sequence-specific DNA binding
A1R12_11680	COG0681	Belongs to the peptidase S26 family
A1R12_11705	COG4940	Competence protein ComGF
A1R12_11715	COG4970	Tfp pilus assembly protein FimT
A1R12_11720	COG4537	Required for transformation and DNA binding
A1R12_11725	COG1459	type II secretion system
A1R12_11730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A1R12_11735	COG0598	Magnesium transport protein CorA
A1R12_11740	COG1253	flavin adenine dinucleotide binding
A1R12_11745	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_11755	COG1393	Belongs to the ArsC family
A1R12_11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_11770	COG0011	TIGRFAM Protein of
A1R12_11780	COG2866	Carboxypeptidase
A1R12_11785	COG1940	carbohydrate kinase activity
A1R12_11790	COG4483	Protein conserved in bacteria
A1R12_11795	COG1757	Na H antiporter
A1R12_11800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1R12_11810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A1R12_11815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1R12_11820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1R12_11825	COG0581	inorganic phosphate transmembrane transporter activity
A1R12_11830	COG0573	inorganic phosphate transmembrane transporter activity
A1R12_11835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A1R12_11850	COG0477	Major facilitator Superfamily
A1R12_11855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1R12_11860	COG2839	Protein conserved in bacteria
A1R12_11865	COG5521	maltodextrose utilization protein MalA
A1R12_11870	COG1388	LysM domain
A1R12_11880	COG4709	membrane
A1R12_11885	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
A1R12_11890	COG0735	belongs to the Fur family
A1R12_11895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_11910	COG0513	Belongs to the DEAD box helicase family
A1R12_11925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A1R12_11930	COG2384	SAM-dependent methyltransferase
A1R12_11935	COG2010	Cytochrome c
A1R12_11940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1R12_11945	COG0358	DNA primase activity
A1R12_11960	COG0517	IMP dehydrogenase activity
A1R12_11965	COG0751	glycine-tRNA ligase activity
A1R12_11980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A1R12_11985	COG0295	cytidine deaminase activity
A1R12_11990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A1R12_12000	COG1480	7TM receptor with intracellular HD hydrolase
A1R12_12005	COG1702	phosphate starvation-inducible protein PhoH
A1R12_12010	COG0561	phosphatase activity
A1R12_12025	COG4864	UPF0365 protein
A1R12_12030	COG1030	water channel activity
A1R12_12035	COG1610	YqeY-like protein
A1R12_12040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A1R12_12045	COG1283	sodium-dependent phosphate transmembrane transporter activity
A1R12_12050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1R12_12055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A1R12_12085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1R12_12100	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_12115	COG1466	dna polymerase III delta subunit
A1R12_12120	COG2333	competence protein COMEC
A1R12_12120	COG0658	competence protein
A1R12_12125	COG2131	deaminase
A1R12_12130	COG1555	photosystem II stabilization
A1R12_12130	COG1596	polysaccharide export
A1R12_12135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A1R12_12140	COG2226	methyltransferase
A1R12_12145	COG0799	negative regulation of ribosome biogenesis
A1R12_12150	COG1713	HD superfamily hydrolase involved in NAD metabolism
A1R12_12160	COG1534	Rna-binding protein
A1R12_12165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A1R12_12170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A1R12_12175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A1R12_12185	COG2755	lipolytic protein G-D-S-L family
A1R12_12190	COG0726	polysaccharide deacetylase
A1R12_12195	COG0398	Pfam SNARE associated Golgi protein
A1R12_12220	COG1794	racemase activity, acting on amino acids and derivatives
A1R12_12230	COG0656	L-ascorbic acid biosynthetic process
A1R12_12260	COG0642	Histidine kinase
A1R12_12260	COG5002	protein histidine kinase activity
A1R12_12265	COG0745	RESPONSE REGULATOR receiver
A1R12_12270	COG2311	Membrane
A1R12_12275	COG0454	-acetyltransferase
A1R12_12280	COG0563	adenylate kinase activity
A1R12_12290	COG2814	Major facilitator Superfamily
A1R12_12305	COG0456	acetyltransferase
A1R12_12310	COG2318	DinB family
A1R12_12320	COG0561	phosphatase activity
A1R12_12325	COG0561	phosphatase activity
A1R12_12335	COG1482	cell wall glycoprotein biosynthetic process
A1R12_12340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1R12_12340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1R12_12340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_12345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_12345	COG3711	transcriptional antiterminator
A1R12_12355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A1R12_12360	COG0583	DNA-binding transcription factor activity
A1R12_12365	COG2814	Major facilitator Superfamily
A1R12_12370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A1R12_12370	COG2124	cytochrome p450
A1R12_12375	COG1309	transcriptional regulator
A1R12_12380	COG2226	methyltransferase
A1R12_12390	COG2116	formate transmembrane transporter activity
A1R12_12395	COG5609	conserved protein (DUF2294)
A1R12_12400	COG3383	formate dehydrogenase (NAD+) activity
A1R12_12405	COG2427	Protein of unknown function (DUF1641)
A1R12_12415	COG0626	cystathionine gamma-synthase activity
A1R12_12420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1R12_12445	COG0768	penicillin binding
A1R12_12475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A1R12_12490	COG4472	Bacterial protein of unknown function (DUF965)
A1R12_12500	COG0628	permease
A1R12_12505	COG1126	abc transporter atp-binding protein
A1R12_12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_12515	COG0765	amino acid transport
A1R12_12520	COG0765	amino acid transport
A1R12_12530	COG3881	PFAM PRC-barrel domain
A1R12_12535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A1R12_12540	COG0457	Tetratricopeptide repeat
A1R12_12550	COG1104	cysteine desulfurase activity
A1R12_12555	COG1959	2 iron, 2 sulfur cluster binding
A1R12_12560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A1R12_12565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A1R12_12585	COG4991	sh3 domain protein
A1R12_12585	COG3103	Sh3 type 3 domain protein
A1R12_12585	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_12595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1R12_12605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A1R12_12605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A1R12_12610	COG5416	Lipopolysaccharide assembly protein A domain
A1R12_12615	COG0490	domain, Protein
A1R12_12620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1R12_12620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1R12_12630	COG2244	polysaccharide biosynthetic process
A1R12_12635	COG2323	membrane
A1R12_12645	COG1862	Preprotein translocase
A1R12_12690	COG1388	LysM domain
A1R12_12700	COG0157	Belongs to the NadC ModD family
A1R12_12705	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A1R12_12710	COG1104	cysteine desulfurase activity
A1R12_12715	COG1827	regulation of RNA biosynthetic process
A1R12_12720	COG0077	Prephenate dehydratase
A1R12_12735	COG3290	protein histidine kinase activity
A1R12_12740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A1R12_12745	COG2868	ribosomal protein
A1R12_12755	COG1994	Peptidase M50
A1R12_12760	COG0739	heme binding
A1R12_12765	COG2894	cell division
A1R12_12775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A1R12_12780	COG1792	Involved in formation and maintenance of cell shape
A1R12_12785	COG1077	Cell shape determining protein MreB Mrl
A1R12_12805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A1R12_12810	COG0285	dihydrofolate synthase activity
A1R12_12815	COG0525	valine-tRNA ligase activity
A1R12_12825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A1R12_12830	COG1388	LysM domain
A1R12_12840	COG0113	porphobilinogen synthase activity
A1R12_12845	COG1587	Uroporphyrinogen-III synthase
A1R12_12855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1R12_12875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A1R12_12880	COG0470	DNA polymerase III
A1R12_12880	COG1067	ATP-dependent peptidase activity
A1R12_12895	COG0457	Tetratricopeptide repeat
A1R12_12895	COG1477	protein flavinylation
A1R12_12910	COG0473	3-isopropylmalate dehydrogenase activity
A1R12_12925	COG0440	acetolactate synthase activity
A1R12_12930	COG0028	Belongs to the TPP enzyme family
A1R12_12945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1R12_12960	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A1R12_12980	COG0622	Phosphoesterase
A1R12_12985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A1R12_12995	COG5401	PFAM Sporulation and spore germination
A1R12_13005	COG1846	Transcriptional regulator
A1R12_13010	COG2197	response regulator
A1R12_13015	COG0824	Thioesterase
A1R12_13020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A1R12_13025	COG1053	succinate dehydrogenase
A1R12_13030	COG2009	succinate dehydrogenase
A1R12_13035	COG1719	4-vinyl reductase, 4VR
A1R12_13040	COG0527	aspartate kinase activity
A1R12_13050	COG3118	belongs to the thioredoxin family
A1R12_13055	COG3534	alpha-L-arabinofuranosidase
A1R12_13060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A1R12_13065	COG2086	electron transfer activity
A1R12_13070	COG1024	Enoyl-CoA hydratase
A1R12_13075	COG1309	transcriptional regulator
A1R12_13080	COG0318	PFAM AMP-dependent synthetase and ligase
A1R12_13090	COG3766	membrane
A1R12_13100	COG1796	DNA polymerase
A1R12_13100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A1R12_13105	COG1286	toxin biosynthetic process
A1R12_13120	COG0072	phenylalanine-tRNA ligase activity
A1R12_13120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1R12_13125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A1R12_13130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1R12_13140	COG3835	regulator
A1R12_13145	COG0277	FAD linked oxidase domain protein
A1R12_13150	COG0247	lactate metabolic process
A1R12_13155	COG1966	Carbon starvation protein
A1R12_13160	COG3534	alpha-L-arabinofuranosidase
A1R12_13165	COG0395	ABC-type sugar transport system, permease component
A1R12_13170	COG1175	transmembrane transport
A1R12_13175	COG1653	transport
A1R12_13185	COG0647	UMP catabolic process
A1R12_13190	COG0235	Class ii aldolase
A1R12_13195	COG1069	ribulokinase activity
A1R12_13200	COG2160	L-arabinose isomerase activity
A1R12_13205	COG3507	Belongs to the glycosyl hydrolase 43 family
A1R12_13210	COG1363	Peptidase, m42
A1R12_13220	COG3326	Membrane
A1R12_13225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A1R12_13235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A1R12_13240	COG1346	cytolysis
A1R12_13245	COG1380	Effector of murein hydrolase LrgA
A1R12_13250	COG3279	Response regulator of the LytR AlgR family
A1R12_13255	COG3275	phosphorelay sensor kinase activity
A1R12_13275	COG0398	Pfam SNARE associated Golgi protein
A1R12_13280	COG1484	DNA-dependent DNA replication
A1R12_13285	COG3611	Membrane attachment protein
A1R12_13300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1R12_13305	COG1733	regulation of RNA biosynthetic process
A1R12_13310	COG2814	Major facilitator Superfamily
A1R12_13315	COG0656	L-ascorbic acid biosynthetic process
A1R12_13320	COG0237	dephospho-CoA kinase activity
A1R12_13325	COG1971	Probably functions as a manganese efflux pump
A1R12_13330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1R12_13335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1R12_13335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1R12_13340	COG5002	protein histidine kinase activity
A1R12_13345	COG0745	RESPONSE REGULATOR receiver
A1R12_13355	COG0538	isocitrate dehydrogenase activity
A1R12_13360	COG0372	Belongs to the citrate synthase family
A1R12_13375	COG0628	permease
A1R12_13380	COG3030	protein affecting phage T7 exclusion by the F plasmid
A1R12_13385	COG0469	pyruvate kinase activity
A1R12_13410	COG0281	malic enzyme
A1R12_13415	COG0587	DNA-directed DNA polymerase activity
A1R12_13435	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A1R12_13445	COG4109	DRTGG domain
A1R12_13455	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_13470	COG0521	Mo-molybdopterin cofactor biosynthetic process
A1R12_13480	COG0827	DNA restriction-modification system
A1R12_13485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A1R12_13490	COG3874	Sporulation protein YtfJ
A1R12_13500	COG1714	RDD family
A1R12_13505	COG0616	signal peptide processing
A1R12_13510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A1R12_13515	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A1R12_13520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1R12_13535	COG1104	cysteine desulfurase activity
A1R12_13540	COG1114	Component of the transport system for branched-chain amino acids
A1R12_13550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A1R12_13555	COG1309	transcriptional regulator
A1R12_13560	COG1956	GAF domain-containing protein
A1R12_13565	COG2203	Gaf domain
A1R12_13565	COG2199	diguanylate cyclase activity
A1R12_13575	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_13580	COG4282	regulation of fungal-type cell wall biogenesis
A1R12_13585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1R12_13585	COG1017	nitric oxide dioxygenase activity
A1R12_13595	COG0693	protein deglycase activity
A1R12_13610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A1R12_13615	COG1378	Sugar-specific transcriptional regulator TrmB
A1R12_13635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1R12_13640	COG0454	-acetyltransferase
A1R12_13645	COG0517	IMP dehydrogenase activity
A1R12_13650	COG0123	including yeast histone deacetylase and acetoin utilization protein
A1R12_13655	COG1360	Flagellar Motor Protein
A1R12_13660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A1R12_13665	COG1609	Transcriptional regulator
A1R12_13670	COG1605	Chorismate mutase
A1R12_13670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A1R12_13675	COG3118	belongs to the thioredoxin family
A1R12_13680	COG4980	gas vesicle protein
A1R12_13685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A1R12_13695	COG1674	ftsk spoiiie
A1R12_13700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1R12_13710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_13720	COG1363	Peptidase, m42
A1R12_13725	COG5584	Small secreted protein
A1R12_13730	COG0281	malic enzyme
A1R12_13735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1R12_13750	COG0510	thiamine kinase activity
A1R12_13755	COG1597	lipid kinase activity
A1R12_13765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A1R12_13770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1R12_13775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1R12_13780	COG2252	PERMEase
A1R12_13785	COG4473	ABC transporter
A1R12_13790	COG1131	(ABC) transporter
A1R12_13795	COG1349	DNA-binding transcription factor activity
A1R12_13800	COG1187	pseudouridine synthase activity
A1R12_13805	COG2244	polysaccharide biosynthetic process
A1R12_13810	COG2081	HI0933 family
A1R12_13815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1R12_13845	COG1486	melibiose metabolic process
A1R12_13855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A1R12_13870	COG2202	Pas domain
A1R12_13870	COG1366	Belongs to the anti-sigma-factor antagonist family
A1R12_13875	COG2814	Major facilitator Superfamily
A1R12_13880	COG5522	Integral membrane protein (intg_mem_TP0381)
A1R12_13885	COG0577	efflux transmembrane transporter activity
A1R12_13890	COG1136	(ABC) transporter
A1R12_13895	COG2205	protein histidine kinase activity
A1R12_13900	COG0745	RESPONSE REGULATOR receiver
A1R12_13905	COG0577	efflux transmembrane transporter activity
A1R12_13910	COG1136	(ABC) transporter
A1R12_13930	COG1131	(ABC) transporter
A1R12_13935	COG1725	Transcriptional regulator
A1R12_13950	COG0477	Major facilitator Superfamily
A1R12_13955	COG1242	4 iron, 4 sulfur cluster binding
A1R12_13960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A1R12_13970	COG0584	glycerophosphoryl diester phosphodiesterase
A1R12_13980	COG2267	carboxylic ester hydrolase activity
A1R12_13985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A1R12_13990	COG1113	amino acid transport
A1R12_13995	COG0367	asparagine synthase
A1R12_14015	COG1506	peptidase
A1R12_14020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1R12_14025	COG1116	anion transmembrane transporter activity
A1R12_14030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1R12_14035	COG0494	nUDIX hydrolase
A1R12_14040	COG4824	toxin secretion phage lysis holin
A1R12_14045	COG0783	Belongs to the Dps family
A1R12_14070	COG0288	reversible hydration of carbon dioxide
A1R12_14080	COG1271	oxidase subunit
A1R12_14085	COG1294	oxidase, subunit
A1R12_14100	COG4948	Mandelate Racemase Muconate Lactonizing
A1R12_14110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A1R12_14115	COG0596	Alpha beta hydrolase
A1R12_14125	COG1169	isochorismate synthase
A1R12_14130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1R12_14135	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A1R12_14270	COG3859	Proton-coupled thiamine transporter YuaJ
A1R12_14275	COG2268	Band 7 protein
A1R12_14280	COG1585	Membrane protein implicated in regulation of membrane protease activity
A1R12_14285	COG2318	DinB family
A1R12_14295	COG1454	alcohol dehydrogenase
A1R12_14305	COG1510	regulation of RNA biosynthetic process
A1R12_14315	COG0569	domain protein
A1R12_14320	COG1705	Flagellar rod assembly protein muramidase FlgJ
A1R12_14325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1R12_14325	COG1017	nitric oxide dioxygenase activity
A1R12_14350	COG0628	permease
A1R12_14355	COG0673	inositol 2-dehydrogenase activity
A1R12_14360	COG0693	protein deglycase activity
A1R12_14365	COG0840	transmembrane signaling receptor activity
A1R12_14370	COG0840	transmembrane signaling receptor activity
A1R12_14375	COG0840	transmembrane signaling receptor activity
A1R12_14380	COG0840	transmembrane signaling receptor activity
A1R12_14395	COG2070	2-Nitropropane dioxygenase
A1R12_14400	COG0432	Pfam Uncharacterised protein family UPF0047
A1R12_14405	COG0366	Alpha amylase catalytic
A1R12_14410	COG1253	flavin adenine dinucleotide binding
A1R12_14415	COG2738	Putative neutral zinc metallopeptidase
A1R12_14430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A1R12_14460	COG1335	isochorismatase
A1R12_14465	COG1979	alcohol dehydrogenase
A1R12_14470	COG1979	alcohol dehydrogenase
A1R12_14475	COG2155	Conserved Protein
A1R12_14480	COG1098	S1 RNA binding domain
A1R12_14485	COG0436	Aminotransferase
A1R12_14490	COG1522	sequence-specific DNA binding
A1R12_14495	COG2267	carboxylic ester hydrolase activity
A1R12_14505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A1R12_14510	COG2205	protein histidine kinase activity
A1R12_14520	COG5018	Exonuclease
A1R12_14525	COG2814	Major facilitator Superfamily
A1R12_14530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1R12_14535	COG3011	Protein conserved in bacteria
A1R12_14545	COG3290	protein histidine kinase activity
A1R12_14550	COG4565	transcriptional regulatory protein
A1R12_14580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1R12_14580	COG2111	Na H antiporter
A1R12_14585	COG2111	Na H antiporter
A1R12_14590	COG1006	Multisubunit Na H antiporter MnhC subunit
A1R12_14595	COG0651	ATP synthesis coupled electron transport
A1R12_14600	COG1863	multisubunit Na H antiporter MnhE subunit
A1R12_14605	COG2212	antiporter activity
A1R12_14610	COG1320	monovalent cation:proton antiporter activity
A1R12_14615	COG2050	protein possibly involved in aromatic compounds catabolism
A1R12_14620	COG2197	response regulator
A1R12_14625	COG4585	Histidine kinase
A1R12_14635	COG0142	geranyltranstransferase activity
A1R12_14650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A1R12_14655	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A1R12_14660	COG1335	isochorismatase
A1R12_14665	COG5506	Protein of unknown function (DUF1694)
A1R12_14680	COG0628	permease
A1R12_14690	COG1418	mRNA catabolic process
A1R12_14695	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_14705	COG1511	domain protein
A1R12_14710	COG1674	ftsk spoiiie
A1R12_14710	COG0433	COG0433 Predicted ATPase
A1R12_14715	COG4499	WXG100 protein secretion system (Wss), protein YukC
A1R12_14720	COG5417	Belongs to the EsaB family
A1R12_14725	COG4842	Belongs to the WXG100 family
A1R12_14730	COG2508	Transcriptional regulator
A1R12_14730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A1R12_14735	COG0686	Belongs to the AlaDH PNT family
A1R12_14740	COG5634	Uncharacterized conserved protein (DUF2278)
A1R12_14745	COG3251	PFAM MbtH domain protein
A1R12_14750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1R12_14755	COG3433	isochorismatase activity
A1R12_14755	COG1535	isochorismatase
A1R12_14760	COG1021	2,3-dihydroxybenzoate-AMP ligase
A1R12_14765	COG1169	isochorismate synthase
A1R12_14770	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_14775	COG2819	hydrolase of the alpha beta superfamily
A1R12_14780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A1R12_14785	COG1268	BioY protein
A1R12_14790	COG2056	Na+-H+ antiporter family
A1R12_14800	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A1R12_14805	COG3584	3D domain protein
A1R12_14815	COG1252	NADH dehydrogenase
A1R12_14845	COG1131	(ABC) transporter
A1R12_14870	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A1R12_14875	COG0316	Belongs to the HesB IscA family
A1R12_14885	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1R12_14895	COG1252	NADH dehydrogenase
A1R12_14900	COG4837	Protein of unknown function (DUF1462)
A1R12_14905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A1R12_14910	COG0823	Involved in the tonB-independent uptake of proteins
A1R12_14910	COG4946	Tricorn protease homolog
A1R12_14910	COG1506	peptidase
A1R12_14920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A1R12_14925	COG0460	homoserine dehydrogenase
A1R12_14930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A1R12_14935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A1R12_14940	COG0647	UMP catabolic process
A1R12_14945	COG2445	Protein of unknown function DUF86
A1R12_14950	COG4470	Protein conserved in bacteria
A1R12_14960	COG0739	heme binding
A1R12_14970	COG0737	Belongs to the 5'-nucleotidase family
A1R12_14975	COG0730	response to heat
A1R12_14980	COG1801	Protein of unknown function DUF72
A1R12_14995	COG2508	Transcriptional regulator
A1R12_15000	COG0457	Tetratricopeptide repeat
A1R12_15015	COG2814	Major facilitator Superfamily
A1R12_15020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A1R12_15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1R12_15030	COG2356	endonuclease I
A1R12_15035	COG3842	ATPase activity
A1R12_15040	COG2188	Transcriptional regulator
A1R12_15045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1R12_15050	COG0395	ABC-type sugar transport system, permease component
A1R12_15055	COG1175	transmembrane transport
A1R12_15060	COG1653	transport
A1R12_15065	COG2222	sugar isomerase
A1R12_15070	COG0789	Transcriptional regulator
A1R12_15085	COG0322	excinuclease ABC activity
A1R12_15090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1R12_15095	COG2226	methyltransferase
A1R12_15105	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_15110	COG0719	Fe-S assembly protein
A1R12_15115	COG0822	iron-sulfur transferase activity
A1R12_15120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1R12_15125	COG0719	Fe-S assembly protein
A1R12_15130	COG0396	ATPase activity
A1R12_15135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1R12_15140	COG1464	Belongs to the NlpA lipoprotein family
A1R12_15145	COG2011	ABC-type metal ion transport system permease component
A1R12_15150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A1R12_15160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1R12_15165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A1R12_15180	COG1393	Belongs to the ArsC family
A1R12_15185	COG1960	acyl-CoA dehydrogenase activity
A1R12_15190	COG0183	Belongs to the thiolase family
A1R12_15195	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1R12_15195	COG1024	Enoyl-CoA hydratase
A1R12_15215	COG5577	PFAM Coat F domain
A1R12_15220	COG1846	Transcriptional regulator
A1R12_15225	COG0477	Major facilitator Superfamily
A1R12_15230	COG1942	4-Oxalocrotonate Tautomerase
A1R12_15235	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_15240	COG0583	DNA-binding transcription factor activity
A1R12_15245	COG0583	DNA-binding transcription factor activity
A1R12_15265	COG1120	ATPase activity
A1R12_15280	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_15285	COG0783	Belongs to the Dps family
A1R12_15290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1R12_15295	COG0745	RESPONSE REGULATOR receiver
A1R12_15300	COG2770	Histidine kinase
A1R12_15300	COG2205	protein histidine kinase activity
A1R12_15305	COG1309	transcriptional regulator
A1R12_15310	COG0114	fumarate hydratase activity
A1R12_15320	COG0697	spore germination
A1R12_15325	COG0814	amino acid
A1R12_15335	COG2197	response regulator
A1R12_15340	COG4585	Histidine kinase
A1R12_15345	COG4758	membrane
A1R12_15350	COG3595	metallopeptidase activity
A1R12_15355	COG1842	Phage shock protein A
A1R12_15360	COG4758	membrane
A1R12_15365	COG2814	Major facilitator Superfamily
A1R12_15370	COG2096	Adenosyltransferase
A1R12_15375	COG1120	ATPase activity
A1R12_15380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_15385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1R12_15390	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_15395	COG3386	PFAM SMP-30 Gluconolaconase
A1R12_15400	COG2205	protein histidine kinase activity
A1R12_15405	COG0745	RESPONSE REGULATOR receiver
A1R12_15415	COG1191	sigma factor activity
A1R12_15420	COG2140	Oxalate decarboxylase
A1R12_15430	COG1120	ATPase activity
A1R12_15435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_15440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_15445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1R12_15450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A1R12_15455	COG0531	amino acid
A1R12_15465	COG1988	membrane-bound metal-dependent
A1R12_15470	COG1368	sulfuric ester hydrolase activity
A1R12_15475	COG1910	domain protein
A1R12_15480	COG0725	ABC transporter, periplasmic molybdate-binding protein
A1R12_15485	COG4149	molybdate abc transporter
A1R12_15490	COG2197	response regulator
A1R12_15495	COG3850	Histidine kinase
A1R12_15500	COG1131	(ABC) transporter
A1R12_15510	COG0842	Transport permease protein
A1R12_15515	COG0656	L-ascorbic acid biosynthetic process
A1R12_15540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A1R12_15545	COG3973	AAA domain
A1R12_15550	COG2860	membrane
A1R12_15560	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A1R12_15565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1R12_15570	COG2217	Heavy metal translocating P-type atpase
A1R12_15575	COG2217	Heavy metal translocating P-type atpase
A1R12_15580	COG2608	mercury ion transmembrane transporter activity
A1R12_15585	COG1937	Protein conserved in bacteria
A1R12_15590	COG0673	inositol 2-dehydrogenase activity
A1R12_15600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1R12_15605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1R12_15610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1R12_15615	COG1126	abc transporter atp-binding protein
A1R12_15620	COG0765	amino acid transport
A1R12_15625	COG0765	amino acid transport
A1R12_15630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_15635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1R12_15640	COG0454	-acetyltransferase
A1R12_15645	COG0583	DNA-binding transcription factor activity
A1R12_15650	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_15655	COG2732	(Barnase) inhibitor
A1R12_15670	COG0557	exoribonuclease II activity
A1R12_15675	COG1647	Serine aminopeptidase, S33
A1R12_15680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1R12_15685	COG1476	TRANSCRIPTIONal
A1R12_15690	COG1396	sequence-specific DNA binding
A1R12_15695	COG1396	sequence-specific DNA binding
A1R12_15700	COG1733	regulation of RNA biosynthetic process
A1R12_15730	COG1174	glycine betaine transport
A1R12_15735	COG1732	Glycine betaine
A1R12_15740	COG1174	glycine betaine transport
A1R12_15745	COG1125	glycine betaine transport
A1R12_15745	COG0517	IMP dehydrogenase activity
A1R12_15750	COG1510	regulation of RNA biosynthetic process
A1R12_15755	COG1174	glycine betaine transport
A1R12_15760	COG1732	Glycine betaine
A1R12_15765	COG1174	glycine betaine transport
A1R12_15770	COG1125	glycine betaine transport
A1R12_15770	COG0517	IMP dehydrogenase activity
A1R12_15775	COG1510	regulation of RNA biosynthetic process
A1R12_15780	COG2095	MarC family integral membrane protein
A1R12_15790	COG3064	Membrane
A1R12_15795	COG4640	response to antibiotic
A1R12_15800	COG0456	acetyltransferase
A1R12_15815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1R12_15830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1R12_15835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1R12_15840	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1R12_15850	COG2234	aminopeptidase activity
A1R12_15870	COG0126	phosphoglycerate kinase activity
A1R12_15880	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1R12_15885	COG2390	Transcriptional regulator
A1R12_15890	COG2814	Major facilitator Superfamily
A1R12_15895	COG1609	Transcriptional regulator
A1R12_15905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1R12_15910	COG0583	DNA-binding transcription factor activity
A1R12_15915	COG0697	spore germination
A1R12_15920	COG1113	amino acid transport
A1R12_15930	COG1609	Transcriptional regulator
A1R12_15940	COG0561	phosphatase activity
A1R12_15945	COG1737	Transcriptional regulator
A1R12_15950	COG1070	Carbohydrate kinase
A1R12_15975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_15980	COG2186	Transcriptional regulator
A1R12_15985	COG1620	l-lactate permease
A1R12_15990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A1R12_16000	COG5039	Polysaccharide pyruvyl transferase
A1R12_16005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1R12_16010	COG0110	maltose O-acetyltransferase activity
A1R12_16015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A1R12_16020	COG2244	polysaccharide biosynthetic process
A1R12_16025	COG1216	Glycosyl transferase, family 2
A1R12_16030	COG5039	Polysaccharide pyruvyl transferase
A1R12_16035	COG1216	Glycosyl transferase, family 2
A1R12_16045	COG0438	transferase activity, transferring glycosyl groups
A1R12_16050	COG1215	transferase activity, transferring glycosyl groups
A1R12_16055	COG0438	transferase activity, transferring glycosyl groups
A1R12_16060	COG1086	Polysaccharide biosynthesis protein
A1R12_16065	COG0489	protein tyrosine kinase activity
A1R12_16070	COG3944	biosynthesis protein
A1R12_16075	COG1396	sequence-specific DNA binding
A1R12_16080	COG2272	Belongs to the type-B carboxylesterase lipase family
A1R12_16085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A1R12_16090	COG2364	Membrane
A1R12_16095	COG0456	acetyltransferase
A1R12_16100	COG3479	Phenolic acid decarboxylase
A1R12_16160	COG2223	nitrite transmembrane transporter activity
A1R12_16165	COG1609	Transcriptional regulator
A1R12_16175	COG0583	DNA-binding transcription factor activity
A1R12_16180	COG2828	Protein conserved in bacteria
A1R12_16185	COG0477	Major facilitator Superfamily
A1R12_16185	COG2814	Major facilitator Superfamily
A1R12_16190	COG1611	Belongs to the LOG family
A1R12_16195	COG1694	Mazg nucleotide pyrophosphohydrolase
A1R12_16200	COG0659	secondary active sulfate transmembrane transporter activity
A1R12_16205	COG0288	reversible hydration of carbon dioxide
A1R12_16215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A1R12_16220	COG0659	secondary active sulfate transmembrane transporter activity
A1R12_16225	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A1R12_16230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_16240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A1R12_16250	COG1051	belongs to the nudix hydrolase family
A1R12_16255	COG0492	ferredoxin-NADP+ reductase activity
A1R12_16260	COG0791	NLP P60 protein
A1R12_16260	COG3883	PFAM NLP P60 protein
A1R12_16265	COG0457	Tetratricopeptide repeat
A1R12_16270	COG5002	protein histidine kinase activity
A1R12_16275	COG0745	RESPONSE REGULATOR receiver
A1R12_16285	COG1132	(ABC) transporter
A1R12_16290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A1R12_16290	COG0140	phosphoribosyl-ATP diphosphatase activity
A1R12_16315	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A1R12_16330	COG4990	cell redox homeostasis
A1R12_16335	COG0110	maltose O-acetyltransferase activity
A1R12_16355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A1R12_16370	COG1309	transcriptional regulator
A1R12_16375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A1R12_16380	COG1950	PFAM Membrane protein of
A1R12_16385	COG1983	PspC domain protein
A1R12_16390	COG3595	metallopeptidase activity
A1R12_16405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1R12_16415	COG4897	Protein conserved in bacteria
A1R12_16420	COG0574	Belongs to the PEP-utilizing enzyme family
A1R12_16420	COG3848	Pyruvate phosphate dikinase
A1R12_16425	COG1309	transcriptional regulator
A1R12_16430	COG2814	Major facilitator Superfamily
A1R12_16480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1R12_16490	COG0793	Belongs to the peptidase S41A family
A1R12_16490	COG3409	Peptidoglycan-binding domain 1 protein
A1R12_16495	COG3420	alginic acid biosynthetic process
A1R12_16500	COG2177	Part of the ABC transporter FtsEX involved in
A1R12_16505	COG2884	Cell division ATP-binding protein ftsE
A1R12_16510	COG2010	Cytochrome c
A1R12_16515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_16520	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A1R12_16530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A1R12_16545	COG1516	flagellar protein fliS
A1R12_16550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A1R12_16555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A1R12_16575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A1R12_16580	COG1256	bacterial-type flagellum assembly
A1R12_16580	COG4786	Flagellar basal body rod
A1R12_16585	COG3418	PFAM FlgN family protein
A1R12_16590	COG2747	anti-sigma28 factor FlgM
A1R12_16600	COG1040	competence protein
A1R12_16610	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A1R12_16615	COG1307	EDD domain protein, DegV family
A1R12_16620	COG2197	response regulator
A1R12_16625	COG4585	Histidine kinase
A1R12_16630	COG1739	Uncharacterized protein family UPF0029
A1R12_16635	COG1316	TRANSCRIPTIONal
A1R12_16640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1R12_16645	COG0438	transferase activity, transferring glycosyl groups
A1R12_16650	COG1215	transferase activity, transferring glycosyl groups
A1R12_16655	COG3206	protein involved in exopolysaccharide biosynthesis
A1R12_16660	COG3307	-O-antigen
A1R12_16665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1R12_16670	COG0438	transferase activity, transferring glycosyl groups
A1R12_16670	COG0297	glycogen (starch) synthase activity
A1R12_16675	COG2244	polysaccharide biosynthetic process
A1R12_16685	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1R12_16685	COG2247	cell wall binding repeat
A1R12_16690	COG2247	cell wall binding repeat
A1R12_16690	COG2385	sporulation resulting in formation of a cellular spore
A1R12_16700	COG1316	TRANSCRIPTIONal
A1R12_16705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A1R12_16710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A1R12_16715	COG1134	teichoic acid transport
A1R12_16720	COG1682	transport, permease protein
A1R12_16725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A1R12_16735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A1R12_16740	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A1R12_16745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A1R12_16750	COG4193	domain, Protein
A1R12_16755	COG1482	cell wall glycoprotein biosynthetic process
A1R12_16760	COG0697	spore germination
A1R12_16765	COG0814	amino acid
A1R12_16775	COG1215	transferase activity, transferring glycosyl groups
A1R12_16780	COG2814	Major facilitator Superfamily
A1R12_16785	COG1316	TRANSCRIPTIONal
A1R12_16790	COG0561	phosphatase activity
A1R12_16795	COG2433	Pfam Transposase IS66
A1R12_16800	COG0791	NLP P60 protein
A1R12_16805	COG2843	Capsule synthesis protein
A1R12_16815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A1R12_16820	COG0697	spore germination
A1R12_16825	COG0814	amino acid
A1R12_16835	COG1609	Transcriptional regulator
A1R12_16840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1R12_16850	COG1129	ABC transporter
A1R12_16855	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1R12_16860	COG1879	ABC-type sugar transport system periplasmic component
A1R12_16865	COG3103	Sh3 type 3 domain protein
A1R12_16870	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1R12_16875	COG3527	Alpha-acetolactate decarboxylase
A1R12_16880	COG0028	Belongs to the TPP enzyme family
A1R12_16885	COG0583	DNA-binding transcription factor activity
A1R12_16890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A1R12_16905	COG5337	Spore coat protein CotH
A1R12_16915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1R12_16925	COG0405	Gamma-glutamyltransferase
A1R12_16930	COG1522	sequence-specific DNA binding
A1R12_16935	COG2059	Chromate
A1R12_16940	COG2059	Chromate
A1R12_16980	COG3878	Protein conserved in bacteria
A1R12_16985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1R12_16990	COG4464	protein tyrosine phosphatase activity
A1R12_16995	COG0489	protein tyrosine kinase activity
A1R12_17000	COG3944	biosynthesis protein
A1R12_17005	COG4715	Zinc finger, swim domain protein
A1R12_17010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A1R12_17015	COG0561	phosphatase activity
A1R12_17020	COG1349	DNA-binding transcription factor activity
A1R12_17025	COG0629	single-stranded DNA binding
A1R12_17050	COG0457	Tetratricopeptide repeat
A1R12_17055	COG4786	Flagellar basal body rod
A1R12_17060	COG4786	Flagellar basal body rod
A1R12_17065	COG1077	Cell shape determining protein MreB Mrl
A1R12_17070	COG1609	Transcriptional regulator
A1R12_17075	COG1846	Transcriptional regulator
A1R12_17080	COG2814	Major facilitator Superfamily
A1R12_17085	COG1953	Uracil, thiamine, allantoin
A1R12_17090	COG0477	Major facilitator Superfamily
A1R12_17095	COG1335	isochorismatase
A1R12_17100	COG0004	ammonium transporteR
A1R12_17105	COG0347	Belongs to the P(II) protein family
A1R12_17110	COG0772	Belongs to the SEDS family
A1R12_17115	COG0671	phosphoesterase, PA-phosphatase related
A1R12_17125	COG0739	heme binding
A1R12_17130	COG1247	-acetyltransferase
A1R12_17145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1R12_17160	COG0726	polysaccharide deacetylase
A1R12_17165	COG1959	2 iron, 2 sulfur cluster binding
A1R12_17180	COG0831	urea catabolic process
A1R12_17190	COG1994	Peptidase M50
A1R12_17195	COG0457	Tetratricopeptide repeat
A1R12_17205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A1R12_17210	COG2304	oxidoreductase activity
A1R12_17215	COG2304	oxidoreductase activity
A1R12_17220	COG2385	sporulation resulting in formation of a cellular spore
A1R12_17225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A1R12_17235	COG4836	Membrane
A1R12_17275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1R12_17305	COG0698	ribose 5-phosphate isomerase
A1R12_17310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1R12_17320	COG0009	L-threonylcarbamoyladenylate synthase
A1R12_17325	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A1R12_17345	COG2890	protein-(glutamine-N5) methyltransferase activity
A1R12_17350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A1R12_17355	COG0346	lactoylglutathione lyase activity
A1R12_17360	COG0789	Transcriptional regulator
A1R12_17365	COG0679	Auxin Efflux Carrier
A1R12_17370	COG0281	malic enzyme
A1R12_17380	COG0254	rRNA binding
A1R12_17385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A1R12_17390	COG1494	fructose-1,6-bisphosphatase
A1R12_17395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A1R12_17405	COG0191	fructose-bisphosphate aldolase activity
A1R12_17410	COG2204	response regulator
A1R12_17415	COG4821	SIS domain
A1R12_17430	COG0247	lactate metabolic process
A1R12_17430	COG2181	nitrate reductase activity
A1R12_17435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1R12_17450	COG1132	(ABC) transporter
A1R12_17455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1R12_17465	COG2181	nitrate reductase activity
A1R12_17470	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A1R12_17475	COG1140	nitrate reductase beta subunit
A1R12_17480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A1R12_17485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1R12_17495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1R12_17500	COG2223	nitrite transmembrane transporter activity
A1R12_17510	COG4506	Protein conserved in bacteria
A1R12_17520	COG3391	amine dehydrogenase activity
A1R12_17525	COG3391	amine dehydrogenase activity
A1R12_17530	COG0457	Tetratricopeptide repeat
A1R12_17575	COG0010	Belongs to the arginase family
A1R12_17580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A1R12_17585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1R12_17600	COG1994	Peptidase M50
A1R12_17605	COG1942	4-Oxalocrotonate Tautomerase
A1R12_17610	COG1846	Transcriptional regulator
A1R12_17615	COG0531	amino acid
A1R12_17620	COG3465	dGTPase activity
A1R12_17625	COG1078	dGTPase activity
A1R12_17640	COG1695	Transcriptional regulator
A1R12_17650	COG1131	(ABC) transporter
A1R12_17655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A1R12_17685	COG0583	DNA-binding transcription factor activity
A1R12_17690	COG2855	membrane
A1R12_17695	COG0280	phosphate acetyltransferase
A1R12_17705	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_17710	COG0436	Aminotransferase
A1R12_17740	COG2814	Major facilitator Superfamily
A1R12_17745	COG2814	Major facilitator Superfamily
A1R12_17750	COG0833	amino acid
A1R12_17755	COG4187	Peptidase family M20/M25/M40
A1R12_17760	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_17765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1R12_17775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A1R12_17780	COG1091	dTDP-4-dehydrorhamnose reductase activity
A1R12_17785	COG1088	dTDP-glucose 4,6-dehydratase activity
A1R12_17790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A1R12_17795	COG3980	spore coat polysaccharide biosynthesis protein
A1R12_17800	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
A1R12_17805	COG2089	acid synthase
A1R12_17810	COG0456	acetyltransferase
A1R12_17815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1R12_17820	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A1R12_17825	COG0463	Glycosyl transferase, family 2
A1R12_17835	COG2363	Small membrane protein
A1R12_17840	COG2233	PERMEase
A1R12_17855	COG1216	Glycosyl transferase, family 2
A1R12_17860	COG0351	phosphomethylpyrimidine kinase
A1R12_17870	COG1621	beta-fructofuranosidase activity
A1R12_17875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1R12_17875	COG1263	PTS System
A1R12_17880	COG3711	transcriptional antiterminator
A1R12_17890	COG1404	Belongs to the peptidase S8 family
A1R12_17895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1R12_17900	COG0778	Nitroreductase
A1R12_17905	COG0772	Belongs to the SEDS family
A1R12_17910	COG0454	-acetyltransferase
A1R12_17930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1R12_17935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1R12_17940	COG2261	transglycosylase associated protein
A1R12_17945	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A1R12_17950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A1R12_17955	COG2246	polysaccharide biosynthetic process
A1R12_17960	COG1309	transcriptional regulator
A1R12_17980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A1R12_17985	COG2837	iron assimilation
A1R12_17990	COG2822	iron ion transport
A1R12_18005	COG0583	DNA-binding transcription factor activity
A1R12_18015	COG1346	cytolysis
A1R12_18020	COG4895	conserved protein (DUF2196)
A1R12_18025	COG0789	Transcriptional regulator
A1R12_18030	COG5504	Zn-dependent protease
A1R12_18035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A1R12_18040	COG0346	lactoylglutathione lyase activity
A1R12_18045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_18050	COG1404	Belongs to the peptidase S8 family
A1R12_18055	COG1442	glycosyl transferase family 8
A1R12_18065	COG2357	RelA SpoT domain protein
A1R12_18070	COG1575	Belongs to the MenA family. Type 1 subfamily
A1R12_18085	COG1696	Membrane protein involved in D-alanine export
A1R12_18095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A1R12_18100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1R12_18105	COG1486	melibiose metabolic process
A1R12_18110	COG1447	Phosphotransferase system cellobiose-specific component IIA
A1R12_18115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_18120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_18125	COG3711	transcriptional antiterminator
A1R12_18125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1R12_18135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_18140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1R12_18150	COG0640	Transcriptional regulator
A1R12_18155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A1R12_18160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_18165	COG1447	Phosphotransferase system cellobiose-specific component IIA
A1R12_18170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1R12_18175	COG2723	6-phospho-beta-galactosidase activity
A1R12_18180	COG1940	carbohydrate kinase activity
A1R12_18185	COG1482	cell wall glycoprotein biosynthetic process
A1R12_18195	COG0753	catalase activity
A1R12_18200	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A1R12_18205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A1R12_18210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A1R12_18215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A1R12_18220	COG4988	ABC transporter
A1R12_18225	COG1294	oxidase, subunit
A1R12_18230	COG1271	oxidase subunit
A1R12_18235	COG3493	citrate carrier protein
A1R12_18240	COG0726	polysaccharide deacetylase
A1R12_18245	COG3842	ATPase activity
A1R12_18250	COG2508	Transcriptional regulator
A1R12_18255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_18265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1R12_18275	COG4894	glucomannan catabolic process
A1R12_18280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A1R12_18285	COG0500	methyltransferase
A1R12_18290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1R12_18310	COG0753	catalase activity
A1R12_18310	COG0693	protein deglycase activity
A1R12_18315	COG2851	Citrate transporter
A1R12_18320	COG2273	Hydrolase Family 16
A1R12_18325	COG3711	transcriptional antiterminator
A1R12_18330	COG2270	Major facilitator Superfamily
A1R12_18335	COG0513	Belongs to the DEAD box helicase family
A1R12_18410	COG0697	spore germination
A1R12_18415	COG0589	response to stress
A1R12_18460	COG3507	Belongs to the glycosyl hydrolase 43 family
A1R12_18485	COG0010	Belongs to the arginase family
A1R12_18490	COG0833	amino acid
A1R12_18495	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A1R12_18500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1R12_18510	COG2390	Transcriptional regulator
A1R12_18515	COG0561	phosphatase activity
A1R12_18545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1R12_18550	COG5294	Protein conserved in bacteria
A1R12_18555	COG0577	efflux transmembrane transporter activity
A1R12_18560	COG1136	(ABC) transporter
A1R12_18565	COG2205	protein histidine kinase activity
A1R12_18570	COG0745	RESPONSE REGULATOR receiver
A1R12_18575	COG2205	protein histidine kinase activity
A1R12_18580	COG0745	RESPONSE REGULATOR receiver
A1R12_18610	COG1082	Xylose isomerase domain protein TIM barrel
A1R12_18620	COG2814	Major facilitator Superfamily
A1R12_18650	COG1349	DNA-binding transcription factor activity
A1R12_18655	COG0667	Aldo Keto reductase
A1R12_18660	COG2814	Major facilitator Superfamily
A1R12_18675	COG1028	Short-chain dehydrogenase reductase Sdr
A1R12_18680	COG2197	response regulator
A1R12_18685	COG4585	Histidine kinase
A1R12_18690	COG3239	Fatty acid desaturase
A1R12_18700	COG1309	transcriptional regulator
A1R12_18705	COG1012	belongs to the aldehyde dehydrogenase family
A1R12_18710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1R12_18720	COG0640	Transcriptional regulator
A1R12_18725	COG2814	Major facilitator Superfamily
A1R12_18730	COG1714	RDD family
A1R12_18740	COG0450	alkyl hydroperoxide reductase
A1R12_18745	COG3634	alkyl hydroperoxide reductase activity
A1R12_18755	COG1113	amino acid transport
A1R12_18765	COG2080	2 iron, 2 sulfur cluster binding
A1R12_18780	COG2068	MobA-Related Protein
A1R12_18785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A1R12_18840	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A1R12_18845	COG0667	Aldo Keto reductase
A1R12_18850	COG0456	acetyltransferase
A1R12_18855	COG0457	Tetratricopeptide repeat
A1R12_18860	COG0010	Belongs to the arginase family
A1R12_18865	COG0833	amino acid
A1R12_18870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1R12_18875	COG5658	integral membrane protein
A1R12_18880	COG0640	Transcriptional regulator
A1R12_18885	COG3829	transcription factor binding
A1R12_18895	COG0488	(ABC) transporter
A1R12_18910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A1R12_18915	COG3850	Histidine kinase
A1R12_18915	COG5002	protein histidine kinase activity
A1R12_18920	COG0745	RESPONSE REGULATOR receiver
A1R12_18925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1R12_18930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A1R12_18935	COG4853	Protein conserved in bacteria
A1R12_18940	COG4863	YycH protein
A1R12_18945	COG5002	protein histidine kinase activity
A1R12_18950	COG0745	RESPONSE REGULATOR receiver
A1R12_18985	COG0346	lactoylglutathione lyase activity
A1R12_18990	COG0305	Participates in initiation and elongation during chromosome replication
A1R12_19005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A1R12_19010	COG0297	glycogen (starch) synthase activity
A1R12_19020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A1R12_19025	COG0438	transferase activity, transferring glycosyl groups
A1R12_19035	COG2112	serine threonine protein kinase
A1R12_19045	COG2801	Transposase and inactivated derivatives
A1R12_19055	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A1R12_19060	COG4241	membrane
A1R12_19065	COG5577	PFAM Coat F domain
A1R12_19070	COG1733	regulation of RNA biosynthetic process
A1R12_19080	COG0697	spore germination
A1R12_19090	COG1621	beta-fructofuranosidase activity
A1R12_19095	COG1802	Transcriptional regulator
A1R12_19100	COG2318	DinB family
A1R12_19105	COG2211	Major facilitator Superfamily
A1R12_19110	COG0697	spore germination
A1R12_19120	COG0778	Nitroreductase
A1R12_19125	COG1846	Transcriptional regulator
A1R12_19130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A1R12_19135	COG1846	Transcriptional regulator
A1R12_19140	COG2153	protein acetylation
A1R12_19150	COG0546	phosphoglycolate phosphatase activity
A1R12_19180	COG1404	Belongs to the peptidase S8 family
A1R12_19185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1R12_19190	COG0697	spore germination
A1R12_19195	COG1078	dGTPase activity
A1R12_19205	COG4978	Transcriptional regulator
A1R12_19205	COG0789	Transcriptional regulator
A1R12_19210	COG1811	Na channel or pump
A1R12_19215	COG1331	Highly conserved protein containing a thioredoxin domain
A1R12_19220	COG1266	CAAX protease self-immunity
A1R12_19225	COG0477	Major facilitator Superfamily
A1R12_19225	COG2814	Major facilitator Superfamily
A1R12_19230	COG0346	lactoylglutathione lyase activity
A1R12_19235	COG1609	Transcriptional regulator
A1R12_19240	COG0708	Exodeoxyribonuclease III
A1R12_19245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1R12_19250	COG2169	Transcriptional regulator
A1R12_19260	COG0629	single-stranded DNA binding
A1R12_19270	COG0012	GTP binding
A1R12_19275	COG0243	molybdopterin cofactor binding
A1R12_19280	COG4481	Protein conserved in bacteria
A1R12_19285	COG3949	Membrane
A1R12_19300	COG1475	DNA binding
A1R12_19305	COG1192	Involved in chromosome partitioning
A1R12_19330	COG1847	R3H domain protein
A1R12_19335	COG0706	membrane insertase activity
A1R12_19350	COG0592	DNA-directed DNA polymerase activity
A1R12_19355	COG2501	S4 domain
A1R12_19370	COG0187	DNA topoisomerase II activity
A1R12_19375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner