locus-tag	class	description
KEF49_00010	COG0592	DNA-directed DNA polymerase activity
KEF49_00015	COG2501	S4 domain
KEF49_00030	COG0187	DNA topoisomerase II activity
KEF49_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KEF49_00070	COG0516	GMP reductase activity
KEF49_00070	COG0517	IMP dehydrogenase activity
KEF49_00075	COG1686	Belongs to the peptidase S11 family
KEF49_00095	COG1929	Belongs to the glycerate kinase type-1 family
KEF49_00105	COG1428	Deoxynucleoside kinase
KEF49_00110	COG1428	Deoxynucleoside kinase
KEF49_00115	COG1388	LysM domain
KEF49_00115	COG3858	chitin binding
KEF49_00120	COG1335	isochorismatase
KEF49_00125	COG0590	tRNA wobble adenosine to inosine editing
KEF49_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KEF49_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KEF49_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KEF49_00195	COG3853	Toxic anion resistance protein (TelA)
KEF49_00200	COG1982	Orn Lys Arg decarboxylase major
KEF49_00210	COG3870	Protein conserved in bacteria
KEF49_00215	COG1728	Protein conserved in bacteria
KEF49_00220	COG0470	DNA polymerase III
KEF49_00225	COG1774	PSP1 C-terminal conserved region
KEF49_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KEF49_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KEF49_00250	COG2002	toxin-antitoxin pair type II binding
KEF49_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KEF49_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KEF49_00260	COG0084	hydrolase, TatD family'
KEF49_00265	COG3584	3D domain protein
KEF49_00265	COG3583	domain protein
KEF49_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KEF49_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KEF49_00285	COG4466	Protein conserved in bacteria
KEF49_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KEF49_00305	COG0251	oxidation-reduction process
KEF49_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KEF49_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KEF49_00345	COG2002	toxin-antitoxin pair type II binding
KEF49_00350	COG2244	polysaccharide biosynthetic process
KEF49_00355	COG3956	TIGRFAM MazG family protein
KEF49_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KEF49_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KEF49_00380	COG1098	S1 RNA binding domain
KEF49_00395	COG2208	phosphoserine phosphatase activity
KEF49_00400	COG2304	oxidoreductase activity
KEF49_00405	COG0515	serine threonine protein kinase
KEF49_00410	COG0037	tRNA processing
KEF49_00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KEF49_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KEF49_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KEF49_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KEF49_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KEF49_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
KEF49_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KEF49_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KEF49_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KEF49_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KEF49_00475	COG1396	sequence-specific DNA binding
KEF49_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KEF49_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KEF49_00565	COG4463	regulation of RNA biosynthetic process
KEF49_00570	COG3880	PFAM UvrB UvrC protein
KEF49_00580	COG0542	response to heat
KEF49_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KEF49_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KEF49_00595	COG4956	integral membrane protein (PIN domain superfamily)
KEF49_00615	COG1045	serine acetyltransferase
KEF49_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KEF49_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KEF49_00635	COG3688	RNA-binding protein containing a PIN domain
KEF49_00640	COG1595	DNA-templated transcription, initiation
KEF49_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KEF49_00655	COG0250	Participates in transcription elongation, termination and antitermination
KEF49_00680	COG2813	Specifically methylates the guanine in position
KEF49_00695	COG1358	cellular component organization or biogenesis
KEF49_00720	COG0596	Alpha beta hydrolase
KEF49_00830	COG0201	protein transport
KEF49_00840	COG0024	Methionine aminopeptidase
KEF49_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KEF49_00875	COG1122	ATPase activity
KEF49_00880	COG1122	ATPase activity
KEF49_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KEF49_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KEF49_00905	COG2226	methyltransferase
KEF49_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_00920	COG0489	protein tyrosine kinase activity
KEF49_00930	COG2194	sulfuric ester hydrolase activity
KEF49_00935	COG0726	polysaccharide deacetylase
KEF49_00995	COG0738	Major facilitator superfamily
KEF49_01000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KEF49_01015	COG0659	secondary active sulfate transmembrane transporter activity
KEF49_01020	COG0385	Bile acid
KEF49_01025	COG2819	hydrolase of the alpha beta superfamily
KEF49_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KEF49_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KEF49_01045	COG2207	Transcriptional regulator
KEF49_01050	COG3876	Protein conserved in bacteria
KEF49_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
KEF49_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KEF49_01065	COG1263	PTS System
KEF49_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KEF49_01080	COG1683	Conserved Protein
KEF49_01110	COG1595	DNA-templated transcription, initiation
KEF49_01115	COG5662	AntiSigma factor
KEF49_01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KEF49_01125	COG4856	YbbR-like protein
KEF49_01150	COG0515	serine threonine protein kinase
KEF49_01160	COG2226	methyltransferase
KEF49_01170	COG1346	cytolysis
KEF49_01175	COG1380	Effector of murein hydrolase LrgA
KEF49_01180	COG1846	Transcriptional regulator
KEF49_01185	COG1113	amino acid transport
KEF49_01190	COG1011	Hydrolase
KEF49_01195	COG4585	Histidine kinase
KEF49_01200	COG2197	response regulator
KEF49_01205	COG1131	(ABC) transporter
KEF49_01225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KEF49_01245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_01245	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_01245	COG3321	synthase
KEF49_01245	COG4221	oxidoreductase activity
KEF49_01250	COG0300	oxidoreductase activity
KEF49_01250	COG3321	synthase
KEF49_01250	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_01250	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_01290	COG0531	amino acid
KEF49_01300	COG0584	glycerophosphoryl diester phosphodiesterase
KEF49_01305	COG2271	Major facilitator Superfamily
KEF49_01315	COG2368	4-hydroxyphenylacetate
KEF49_01325	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_01340	COG0371	Dehydrogenase
KEF49_01350	COG1183	phosphatidylcholine synthase activity
KEF49_01355	COG0586	Pfam SNARE associated Golgi protein
KEF49_01360	COG0688	phosphatidylethanolamine metabolic process
KEF49_01375	COG1301	dicarboxylic acid transport
KEF49_01380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KEF49_01385	COG0833	amino acid
KEF49_01390	COG2040	homocysteine
KEF49_01395	COG1115	amino acid carrier protein
KEF49_01400	COG2066	Belongs to the glutaminase family
KEF49_01405	COG4191	Histidine kinase
KEF49_01410	COG0784	Response regulator, receiver
KEF49_01415	COG3173	Aminoglycoside phosphotransferase
KEF49_01425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KEF49_01430	COG0778	Nitroreductase
KEF49_01435	COG0346	lactoylglutathione lyase activity
KEF49_01440	COG2259	Doxx family
KEF49_01445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_01460	COG3773	Cell wall hydrolase
KEF49_01465	COG3540	Alkaline phosphatase
KEF49_01470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KEF49_01475	COG0805	protein transport
KEF49_01480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KEF49_01485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KEF49_01490	COG0477	Major facilitator Superfamily
KEF49_01495	COG1309	transcriptional regulator
KEF49_01500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KEF49_01505	COG3012	SEC-C Motif Domain Protein
KEF49_01505	COG1405	negative regulation of cell septum assembly
KEF49_01510	COG0667	Aldo Keto reductase
KEF49_01520	COG1595	DNA-templated transcription, initiation
KEF49_01525	COG1595	DNA-templated transcription, initiation
KEF49_01530	COG1876	peptidase activity
KEF49_01535	COG0457	Tetratricopeptide repeat
KEF49_01540	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_01545	COG0366	Alpha amylase catalytic
KEF49_01550	COG0803	Belongs to the bacterial solute-binding protein 9 family
KEF49_01555	COG1121	(ABC) transporter
KEF49_01560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KEF49_01565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_01570	COG2310	stress, protein
KEF49_01575	COG2310	stress, protein
KEF49_01580	COG2310	stress, protein
KEF49_01585	COG0861	Integral membrane protein TerC family
KEF49_01595	COG3853	Toxic anion resistance protein (TelA)
KEF49_01600	COG0477	Major facilitator Superfamily
KEF49_01605	COG4175	Glycine betaine
KEF49_01605	COG0517	IMP dehydrogenase activity
KEF49_01610	COG4176	ABC-type proline glycine betaine transport system permease component
KEF49_01615	COG2113	Glycine betaine
KEF49_01620	COG1473	amidohydrolase
KEF49_01625	COG1288	antiporter activity
KEF49_01645	COG2814	Major facilitator Superfamily
KEF49_01650	COG1846	Transcriptional regulator
KEF49_01655	COG1280	lysine exporter protein (LysE YggA)
KEF49_01660	COG3403	YqcI/YcgG family
KEF49_01665	COG1113	amino acid transport
KEF49_01670	COG3665	Urea carboxylase-associated protein
KEF49_01680	COG1082	Xylose isomerase domain protein TIM barrel
KEF49_01685	COG2271	Major facilitator Superfamily
KEF49_01690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KEF49_01695	COG3458	cephalosporin-C deacetylase activity
KEF49_01700	COG3541	Predicted nucleotidyltransferase
KEF49_01705	COG0506	proline dehydrogenase activity
KEF49_01710	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_01715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KEF49_01720	COG2508	Transcriptional regulator
KEF49_01730	COG1587	Uroporphyrinogen-III synthase
KEF49_01730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KEF49_01735	COG2146	nitrite reductase [NAD(P)H] activity
KEF49_01740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KEF49_01750	COG0523	cobalamin synthesis protein
KEF49_01755	COG1063	alcohol dehydrogenase
KEF49_01760	COG1714	RDD family
KEF49_01770	COG2723	6-phospho-beta-galactosidase activity
KEF49_01780	COG3209	COG3209 Rhs family protein
KEF49_01785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KEF49_01790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KEF49_01795	COG1733	regulation of RNA biosynthetic process
KEF49_01800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_01805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_01810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_01815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KEF49_01830	COG2364	Membrane
KEF49_01835	COG1126	abc transporter atp-binding protein
KEF49_01840	COG0765	amino acid transport
KEF49_01845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_01850	COG0583	DNA-binding transcription factor activity
KEF49_01855	COG0163	prenyltransferase activity
KEF49_01860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KEF49_01875	COG3104	oligopeptide transport
KEF49_01880	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_01890	COG0697	spore germination
KEF49_01900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KEF49_01905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_01910	COG0456	acetyltransferase
KEF49_01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_01920	COG0765	amino acid transport
KEF49_01925	COG1126	abc transporter atp-binding protein
KEF49_01930	COG1473	amidohydrolase
KEF49_01935	COG2079	MmgE PrpD family protein
KEF49_01940	COG1136	(ABC) transporter
KEF49_01945	COG0577	efflux transmembrane transporter activity
KEF49_01950	COG0745	RESPONSE REGULATOR receiver
KEF49_01955	COG3850	Histidine kinase
KEF49_01955	COG5002	protein histidine kinase activity
KEF49_01960	COG0457	Tetratricopeptide repeat
KEF49_01975	COG0527	aspartate kinase activity
KEF49_01980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_01985	COG4605	iron ion homeostasis
KEF49_01990	COG4604	ABC transporter, ATP-binding protein
KEF49_01995	COG4607	ABC-type enterochelin transport system periplasmic component
KEF49_02000	COG2814	Major facilitator Superfamily
KEF49_02005	COG1309	transcriptional regulator
KEF49_02010	COG0778	Nitroreductase
KEF49_02015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KEF49_02020	COG0640	Transcriptional regulator
KEF49_02025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KEF49_02030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KEF49_02035	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_02040	COG4975	Glucose uptake
KEF49_02045	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_02050	COG4549	nuclear export factor GLE1
KEF49_02055	COG2372	response to copper ion
KEF49_02055	COG1276	copper resistance
KEF49_02060	COG1349	DNA-binding transcription factor activity
KEF49_02070	COG2213	PTS system mannitol-specific
KEF49_02075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_02085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KEF49_02095	COG0561	phosphatase activity
KEF49_02105	COG1914	H( )-stimulated, divalent metal cation uptake system
KEF49_02115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KEF49_02120	COG1984	allophanate hydrolase subunit 2
KEF49_02125	COG1414	Transcriptional regulator
KEF49_02130	COG2755	lipolytic protein G-D-S-L family
KEF49_02140	COG2329	Antibiotic biosynthesis monooxygenase
KEF49_02145	COG0768	penicillin binding
KEF49_02150	COG4989	oxidoreductase activity
KEF49_02155	COG3711	transcriptional antiterminator
KEF49_02160	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_02165	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_02170	COG1917	Cupin 2, conserved barrel domain protein
KEF49_02175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KEF49_02180	COG3871	stress protein (general stress protein 26)
KEF49_02190	COG2814	Major facilitator Superfamily
KEF49_02195	COG1522	sequence-specific DNA binding
KEF49_02200	COG0551	DNA topoisomerase type I activity
KEF49_02200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KEF49_02205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KEF49_02210	COG3706	GGDEF domain
KEF49_02215	COG5298	Protein conserved in bacteria
KEF49_02220	COG1215	transferase activity, transferring glycosyl groups
KEF49_02230	COG0531	amino acid
KEF49_02235	COG0028	Belongs to the TPP enzyme family
KEF49_02260	COG1914	H( )-stimulated, divalent metal cation uptake system
KEF49_02270	COG4876	unkown
KEF49_02275	COG2217	Heavy metal translocating P-type atpase
KEF49_02280	COG3729	General stress protein
KEF49_02290	COG3546	catalase activity
KEF49_02295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KEF49_02300	COG3290	protein histidine kinase activity
KEF49_02305	COG4565	transcriptional regulatory protein
KEF49_02310	COG1301	dicarboxylic acid transport
KEF49_02315	COG0628	permease
KEF49_02320	COG1131	(ABC) transporter
KEF49_02325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KEF49_02335	COG1960	acyl-CoA dehydrogenase activity
KEF49_02350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KEF49_02355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_02365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KEF49_02370	COG0513	Belongs to the DEAD box helicase family
KEF49_02375	COG3402	PFAM membrane-flanked domain
KEF49_02380	COG3428	Bacterial PH domain
KEF49_02385	COG0705	Rhomboid family
KEF49_02400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KEF49_02405	COG0864	Transcriptional regulator
KEF49_02410	COG2337	Toxic component of a toxin-antitoxin (TA) module
KEF49_02415	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_02420	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_02425	COG2172	sigma factor antagonist activity
KEF49_02430	COG2208	phosphoserine phosphatase activity
KEF49_02435	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_02445	COG1191	sigma factor activity
KEF49_02450	COG2208	phosphoserine phosphatase activity
KEF49_02455	COG2183	response to ionizing radiation
KEF49_02530	COG3764	Sortase (surface protein transpeptidase)
KEF49_02535	COG1278	Cold shock
KEF49_02540	COG1329	Transcriptional regulator
KEF49_02545	COG0662	Cupin 2, conserved barrel domain protein
KEF49_02550	COG1959	2 iron, 2 sulfur cluster binding
KEF49_02560	COG1278	Cold shock
KEF49_02590	COG0477	Major facilitator Superfamily
KEF49_02595	COG3621	Patatin-like phospholipase
KEF49_02625	COG0456	acetyltransferase
KEF49_02630	COG2207	Transcriptional regulator
KEF49_02630	COG3708	Transcriptional regulator
KEF49_02635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KEF49_02655	COG1064	alcohol dehydrogenase
KEF49_02660	COG0789	Transcriptional regulator
KEF49_02670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KEF49_02675	COG2808	Putative FMN-binding domain
KEF49_02680	COG0697	spore germination
KEF49_02685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KEF49_02690	COG5577	PFAM Coat F domain
KEF49_02700	COG1063	alcohol dehydrogenase
KEF49_02705	COG5577	PFAM Coat F domain
KEF49_02720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KEF49_02725	COG0488	(ABC) transporter
KEF49_02730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KEF49_02735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_02745	COG2814	Major facilitator Superfamily
KEF49_02750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KEF49_02760	COG0730	response to heat
KEF49_02765	COG0456	acetyltransferase
KEF49_02770	COG0789	Transcriptional regulator
KEF49_02770	COG4978	Transcriptional regulator
KEF49_02775	COG0697	spore germination
KEF49_02780	COG1051	belongs to the nudix hydrolase family
KEF49_02785	COG0596	Alpha beta hydrolase
KEF49_02790	COG0473	3-isopropylmalate dehydrogenase activity
KEF49_02795	COG1802	Transcriptional regulator
KEF49_02800	COG1819	glycosyl
KEF49_02810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KEF49_02820	COG1388	LysM domain
KEF49_02825	COG2814	Major facilitator Superfamily
KEF49_02835	COG2186	Transcriptional regulator
KEF49_02840	COG2807	transmembrane transport
KEF49_02845	COG2076	Multidrug Resistance protein
KEF49_02850	COG2076	Multidrug Resistance protein
KEF49_02855	COG1309	transcriptional regulator
KEF49_02860	COG0531	amino acid
KEF49_02870	COG3832	glyoxalase III activity
KEF49_02875	COG0604	alcohol dehydrogenase
KEF49_02880	COG2814	Major facilitator Superfamily
KEF49_02920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KEF49_02925	COG0802	atpase or kinase
KEF49_02930	COG1214	PFAM Peptidase M22, glycoprotease
KEF49_02935	COG0456	acetyltransferase
KEF49_02940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KEF49_02945	COG0488	(ABC) transporter
KEF49_02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KEF49_02965	COG0805	protein transport
KEF49_02975	COG1266	CAAX protease self-immunity
KEF49_02990	COG1073	alpha beta
KEF49_02995	COG0457	Tetratricopeptide repeat
KEF49_03000	COG1063	alcohol dehydrogenase
KEF49_03005	COG2211	Major facilitator Superfamily
KEF49_03010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KEF49_03020	COG1842	Phage shock protein A
KEF49_03025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KEF49_03030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KEF49_03035	COG4260	virion core protein, lumpy skin disease virus
KEF49_03040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KEF49_03040	COG2755	lipolytic protein G-D-S-L family
KEF49_03050	COG1595	DNA-templated transcription, initiation
KEF49_03055	COG1063	alcohol dehydrogenase
KEF49_03060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KEF49_03065	COG0823	Involved in the tonB-independent uptake of proteins
KEF49_03075	COG2132	Multicopper oxidase
KEF49_03080	COG1113	amino acid transport
KEF49_03090	COG0017	Asparaginyl-tRNA synthetase
KEF49_03105	COG1181	Belongs to the D-alanine--D-alanine ligase family
KEF49_03110	COG2175	clavaminate synthase activity
KEF49_03115	COG1794	racemase activity, acting on amino acids and derivatives
KEF49_03130	COG0714	Associated with various cellular activities
KEF49_03135	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KEF49_03140	COG1305	Transglutaminase-like
KEF49_03160	COG2252	PERMEase
KEF49_03165	COG3064	Membrane
KEF49_03185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KEF49_03190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KEF49_03195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KEF49_03200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KEF49_03205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KEF49_03220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KEF49_03230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KEF49_03235	COG0138	bifunctional purine biosynthesis protein purh
KEF49_03240	COG0151	Belongs to the GarS family
KEF49_03245	COG1522	sequence-specific DNA binding
KEF49_03250	COG0531	amino acid
KEF49_03260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KEF49_03265	COG1470	cell adhesion involved in biofilm formation
KEF49_03270	COG4496	protein, YerC YecD
KEF49_03275	COG0069	glutamate synthase activity
KEF49_03285	COG0210	DNA helicase
KEF49_03295	COG4851	CamS sex pheromone cAM373 precursor
KEF49_03300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KEF49_03305	COG1285	pathogenesis
KEF49_03310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KEF49_03330	COG1309	transcriptional regulator
KEF49_03335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KEF49_03340	COG1597	lipid kinase activity
KEF49_03345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KEF49_03385	COG5444	nuclease activity
KEF49_03415	COG3546	catalase activity
KEF49_03420	COG0454	-acetyltransferase
KEF49_03430	COG2323	membrane
KEF49_03435	COG2329	Antibiotic biosynthesis monooxygenase
KEF49_03440	COG0346	lactoylglutathione lyase activity
KEF49_03445	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_03450	COG5583	Uncharacterized small protein (DUF2292)
KEF49_03455	COG0196	riboflavin kinase activity
KEF49_03460	COG0670	Belongs to the BI1 family
KEF49_03470	COG1846	Transcriptional regulator
KEF49_03475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KEF49_03485	COG2124	cytochrome p450
KEF49_03485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KEF49_03490	COG1368	sulfuric ester hydrolase activity
KEF49_03495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KEF49_03500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KEF49_03505	COG1442	glycosyl transferase family 8
KEF49_03510	COG1216	Glycosyl transferase, family 2
KEF49_03515	COG1442	glycosyl transferase family 8
KEF49_03520	COG2223	nitrite transmembrane transporter activity
KEF49_03525	COG0531	amino acid
KEF49_03530	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_03535	COG0840	transmembrane signaling receptor activity
KEF49_03540	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_03545	COG0457	Tetratricopeptide repeat
KEF49_03545	COG0463	Glycosyl transferase, family 2
KEF49_03550	COG0488	(ABC) transporter
KEF49_03560	COG0789	Transcriptional regulator
KEF49_03565	COG2814	Major facilitator Superfamily
KEF49_03570	COG0488	(ABC) transporter
KEF49_03575	COG0513	Belongs to the DEAD box helicase family
KEF49_03580	COG2130	NADP-dependent
KEF49_03595	COG3866	Pectate lyase
KEF49_03600	COG0471	metal ion transport
KEF49_03605	COG0745	RESPONSE REGULATOR receiver
KEF49_03605	COG2972	Histidine kinase
KEF49_03620	COG3764	Sortase (surface protein transpeptidase)
KEF49_03625	COG3290	protein histidine kinase activity
KEF49_03630	COG4565	transcriptional regulatory protein
KEF49_03635	COG3181	Tripartite tricarboxylate transporter family receptor
KEF49_03640	COG2851	Citrate transporter
KEF49_03645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_03650	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KEF49_03660	COG2258	MOSC domain
KEF49_03680	COG0024	Methionine aminopeptidase
KEF49_03685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_03685	COG1263	PTS System
KEF49_03695	COG1368	sulfuric ester hydrolase activity
KEF49_03705	COG0071	Belongs to the small heat shock protein (HSP20) family
KEF49_03720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_03720	COG1263	PTS System
KEF49_03725	COG0366	Alpha amylase catalytic
KEF49_03730	COG2188	Transcriptional regulator
KEF49_03735	COG0778	Nitroreductase
KEF49_03750	COG0737	Belongs to the 5'-nucleotidase family
KEF49_03755	COG0693	protein deglycase activity
KEF49_03760	COG1609	Transcriptional regulator
KEF49_03785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KEF49_03790	COG4980	gas vesicle protein
KEF49_03795	COG1295	ribonuclease BN
KEF49_03800	COG0477	Major facilitator Superfamily
KEF49_03805	COG0387	Pfam Sodium calcium exchanger
KEF49_03815	COG0668	transmembrane transport
KEF49_03820	COG0535	radical SAM domain protein
KEF49_03830	COG0726	polysaccharide deacetylase
KEF49_03835	COG2084	Dehydrogenase
KEF49_03845	COG0598	Magnesium transport protein CorA
KEF49_03850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KEF49_03855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KEF49_03865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KEF49_03870	COG4637	Psort location Cytoplasmic, score
KEF49_03875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KEF49_03880	COG0022	dehydrogenase e1 component
KEF49_03885	COG0508	dehydrogenase complex catalyzes the overall conversion of
KEF49_03890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KEF49_03895	COG3284	Transcriptional regulator
KEF49_03905	COG1486	melibiose metabolic process
KEF49_03910	COG1737	Transcriptional regulator
KEF49_03915	COG1263	PTS System
KEF49_03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_03920	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_03925	COG1132	(ABC) transporter
KEF49_03930	COG1132	(ABC) transporter
KEF49_03935	COG2259	Doxx family
KEF49_03940	COG2514	catechol 2,3-dioxygenase activity
KEF49_03950	COG1695	Transcriptional regulator
KEF49_03955	COG2249	NAD(P)H dehydrogenase (quinone) activity
KEF49_03960	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
KEF49_03970	COG2732	(Barnase) inhibitor
KEF49_03975	COG2318	DinB family
KEF49_03980	COG2814	Major facilitator Superfamily
KEF49_03985	COG1846	Transcriptional regulator
KEF49_03990	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KEF49_03990	COG0392	lysyltransferase activity
KEF49_03995	COG0384	phenazine biosynthesis protein PhzF
KEF49_04000	COG0778	Nitroreductase
KEF49_04015	COG1090	epimerase
KEF49_04030	COG2814	Major facilitator Superfamily
KEF49_04040	COG3591	Belongs to the peptidase S1B family
KEF49_04055	COG3103	Sh3 type 3 domain protein
KEF49_04060	COG5658	integral membrane protein
KEF49_04065	COG0596	Alpha beta hydrolase
KEF49_04070	COG0463	Glycosyl transferase, family 2
KEF49_04075	COG4485	Bacterial membrane protein, YfhO
KEF49_04080	COG1988	membrane-bound metal-dependent
KEF49_04085	COG1194	a g-specific adenine glycosylase
KEF49_04095	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_04115	COG1132	(ABC) transporter
KEF49_04120	COG4129	membrane
KEF49_04130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KEF49_04135	COG0735	belongs to the Fur family
KEF49_04245	COG1757	Na H antiporter
KEF49_04250	COG3340	Belongs to the peptidase S51 family
KEF49_04260	COG0277	FAD linked oxidase domain protein
KEF49_04270	COG0747	negative chemotaxis
KEF49_04280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KEF49_04285	COG0444	Belongs to the ABC transporter superfamily
KEF49_04290	COG4608	Belongs to the ABC transporter superfamily
KEF49_04295	COG0753	catalase activity
KEF49_04305	COG1116	anion transmembrane transporter activity
KEF49_04310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KEF49_04315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KEF49_04335	COG1476	TRANSCRIPTIONal
KEF49_04345	COG3382	B3 4 domain protein
KEF49_04350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KEF49_04360	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KEF49_04365	COG0789	Transcriptional regulator
KEF49_04370	COG1664	Polymer-forming cytoskeletal
KEF49_04375	COG1664	Polymer-forming cytoskeletal
KEF49_04380	COG2766	serine protein kinase
KEF49_04390	COG1846	Transcriptional regulator
KEF49_04395	COG1566	PFAM secretion protein HlyD family protein
KEF49_04400	COG2814	Major facilitator Superfamily
KEF49_04405	COG0655	NAD(P)H dehydrogenase (quinone) activity
KEF49_04420	COG1725	Transcriptional regulator
KEF49_04425	COG1131	(ABC) transporter
KEF49_04430	COG1131	(ABC) transporter
KEF49_04435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KEF49_04440	COG1278	Cold shock
KEF49_04445	COG1464	Belongs to the NlpA lipoprotein family
KEF49_04450	COG3706	GGDEF domain
KEF49_04455	COG1823	symporter activity
KEF49_04480	COG5577	PFAM Coat F domain
KEF49_04485	COG0737	Belongs to the 5'-nucleotidase family
KEF49_04485	COG1525	nuclease
KEF49_04485	COG4085	toxin activity
KEF49_04490	COG3764	Sortase (surface protein transpeptidase)
KEF49_04495	COG0564	pseudouridine synthase activity
KEF49_04505	COG0517	IMP dehydrogenase activity
KEF49_04510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KEF49_04515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KEF49_04515	COG3153	acetyltransferase
KEF49_04520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KEF49_04525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KEF49_04530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KEF49_04540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KEF49_04545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KEF49_04550	COG2203	Gaf domain
KEF49_04550	COG4585	Histidine kinase
KEF49_04555	COG2197	response regulator
KEF49_04560	COG0431	NADPH-dependent FMN reductase
KEF49_04575	COG0791	NLP P60 protein
KEF49_04575	COG1388	LysM domain
KEF49_04580	COG1959	2 iron, 2 sulfur cluster binding
KEF49_04585	COG0668	transmembrane transport
KEF49_04590	COG2719	SpoVR family
KEF49_04595	COG1785	Belongs to the alkaline phosphatase family
KEF49_04600	COG0791	NLP P60 protein
KEF49_04600	COG1388	LysM domain
KEF49_04605	COG0583	DNA-binding transcription factor activity
KEF49_04610	COG0372	Belongs to the citrate synthase family
KEF49_04615	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_04620	COG0531	amino acid
KEF49_04625	COG0733	neurotransmitter:sodium symporter activity
KEF49_04640	COG1595	DNA-templated transcription, initiation
KEF49_04645	COG0204	Acyl-transferase
KEF49_04650	COG1253	flavin adenine dinucleotide binding
KEF49_04655	COG0789	Transcriptional regulator
KEF49_04660	COG0436	Aminotransferase
KEF49_04665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KEF49_04670	COG1253	flavin adenine dinucleotide binding
KEF49_04675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KEF49_04680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KEF49_04685	COG0584	glycerophosphoryl diester phosphodiesterase
KEF49_04695	COG0668	transmembrane transport
KEF49_04700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KEF49_04705	COG0726	polysaccharide deacetylase
KEF49_04710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KEF49_04715	COG3226	Transcriptional regulator
KEF49_04725	COG0589	response to stress
KEF49_04730	COG1132	(ABC) transporter
KEF49_04735	COG1132	(ABC) transporter
KEF49_04740	COG0702	epimerase
KEF49_04755	COG0189	ligase activity
KEF49_04760	COG0189	ligase activity
KEF49_04775	COG0561	phosphatase activity
KEF49_04780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KEF49_04790	COG0475	glutathione-regulated potassium exporter activity
KEF49_04795	COG0490	domain, Protein
KEF49_04805	COG1024	Enoyl-CoA hydratase
KEF49_04815	COG4152	abc transporter atp-binding protein
KEF49_04820	COG1668	transmembrane transport
KEF49_04825	COG0420	3'-5' exonuclease activity
KEF49_04830	COG4717	serine-type aminopeptidase activity
KEF49_04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KEF49_04880	COG4980	gas vesicle protein
KEF49_04895	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KEF49_04900	COG0537	adenosine 5'-monophosphoramidase activity
KEF49_04905	COG1131	(ABC) transporter
KEF49_04910	COG4473	ABC transporter
KEF49_04920	COG1473	amidohydrolase
KEF49_04925	COG3069	C4-dicarboxylate transmembrane transporter activity
KEF49_04930	COG2329	Antibiotic biosynthesis monooxygenase
KEF49_04935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KEF49_04945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KEF49_04950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KEF49_04955	COG1309	transcriptional regulator
KEF49_04960	COG1511	domain protein
KEF49_04965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KEF49_04975	COG1363	Peptidase, m42
KEF49_04980	COG1301	dicarboxylic acid transport
KEF49_04990	COG1234	tRNA 3'-trailer cleavage
KEF49_04995	COG0095	Lipoate-protein ligase
KEF49_05000	COG0702	epimerase
KEF49_05005	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_05015	COG0501	Belongs to the peptidase M48B family
KEF49_05020	COG1404	Belongs to the peptidase S8 family
KEF49_05025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KEF49_05030	COG0406	alpha-ribazole phosphatase activity
KEF49_05035	COG0183	Belongs to the thiolase family
KEF49_05040	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_05045	COG1268	BioY protein
KEF49_05050	COG0840	transmembrane signaling receptor activity
KEF49_05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KEF49_05055	COG0723	plastoquinol--plastocyanin reductase activity
KEF49_05060	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_05070	COG4903	ComK protein
KEF49_05075	COG5646	InterPro IPR014922
KEF49_05100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KEF49_05115	COG0398	Pfam SNARE associated Golgi protein
KEF49_05120	COG0681	Belongs to the peptidase S26 family
KEF49_05125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KEF49_05130	COG1846	Transcriptional regulator
KEF49_05135	COG3180	Ammonia monooxygenase
KEF49_05140	COG2814	Major facilitator Superfamily
KEF49_05150	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KEF49_05155	COG2323	membrane
KEF49_05170	COG0420	3'-5' exonuclease activity
KEF49_05175	COG0419	ATPase involved in DNA repair
KEF49_05180	COG1403	HNH endonuclease
KEF49_05220	COG0179	Fumarylacetoacetate (FAA) hydrolase
KEF49_05230	COG1404	Belongs to the peptidase S8 family
KEF49_05240	COG0367	asparagine synthase
KEF49_05245	COG1562	ergosterol biosynthetic process
KEF49_05250	COG0534	Mate efflux family protein
KEF49_05255	COG2207	Transcriptional regulator
KEF49_05255	COG1917	Cupin 2, conserved barrel domain protein
KEF49_05260	COG1609	Transcriptional regulator
KEF49_05265	COG0673	inositol 2-dehydrogenase activity
KEF49_05270	COG2318	DinB family
KEF49_05280	COG1357	PFAM Pentapeptide repeats (8 copies)
KEF49_05290	COG0646	methionine synthase
KEF49_05290	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KEF49_05300	COG2996	Protein conserved in bacteria
KEF49_05305	COG1744	ABC transporter substrate-binding protein PnrA-like
KEF49_05310	COG0840	transmembrane signaling receptor activity
KEF49_05315	COG2124	cytochrome p450
KEF49_05325	COG1307	EDD domain protein, DegV family
KEF49_05330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_05350	COG0561	phosphatase activity
KEF49_05355	COG1073	alpha beta
KEF49_05360	COG2151	metal-sulfur cluster biosynthetic enzyme
KEF49_05370	COG0277	FAD linked oxidase domain protein
KEF49_05375	COG2271	Major facilitator Superfamily
KEF49_05385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KEF49_05395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KEF49_05400	COG0505	Belongs to the CarA family
KEF49_05405	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KEF49_05410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KEF49_05425	COG2267	carboxylic ester hydrolase activity
KEF49_05435	COG1744	ABC transporter substrate-binding protein PnrA-like
KEF49_05450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KEF49_05455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KEF49_05460	COG5504	Zn-dependent protease
KEF49_05465	COG0444	Belongs to the ABC transporter superfamily
KEF49_05470	COG4608	Belongs to the ABC transporter superfamily
KEF49_05480	COG0601	transmembrane transport
KEF49_05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KEF49_05495	COG0180	Tryptophanyl-tRNA synthetase
KEF49_05500	COG4166	transmembrane transport
KEF49_05505	COG0601	transmembrane transport
KEF49_05510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KEF49_05515	COG0444	Belongs to the ABC transporter superfamily
KEF49_05520	COG4608	Belongs to the ABC transporter superfamily
KEF49_05530	COG0456	acetyltransferase
KEF49_05535	COG1393	Belongs to the ArsC family
KEF49_05540	COG0861	Integral membrane protein TerC family
KEF49_05550	COG4862	establishment of competence for transformation
KEF49_05555	COG4469	Competence protein
KEF49_05560	COG1164	Oligoendopeptidase f
KEF49_05570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KEF49_05575	COG2346	COG2346, Truncated hemoglobins
KEF49_05580	COG0741	lytic transglycosylase activity
KEF49_05585	COG4116	CYTH
KEF49_05595	COG2357	RelA SpoT domain protein
KEF49_05600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KEF49_05605	COG0564	pseudouridine synthase activity
KEF49_05615	COG0569	domain protein
KEF49_05615	COG0475	glutathione-regulated potassium exporter activity
KEF49_05620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KEF49_05625	COG0352	thiamine-phosphate diphosphorylase activity
KEF49_05630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KEF49_05635	COG2104	thiamine diphosphate biosynthetic process
KEF49_05645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KEF49_05650	COG0351	phosphomethylpyrimidine kinase
KEF49_05655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KEF49_05710	COG0210	DNA helicase
KEF49_05740	COG2153	protein acetylation
KEF49_05750	COG2382	esterase
KEF49_05755	COG0626	cystathionine gamma-synthase activity
KEF49_05760	COG0626	cystathionine gamma-synthase activity
KEF49_05815	COG2367	Beta-lactamase
KEF49_05820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KEF49_05840	COG1285	pathogenesis
KEF49_05850	COG2205	protein histidine kinase activity
KEF49_05860	COG3383	formate dehydrogenase (NAD+) activity
KEF49_05865	COG2427	Protein of unknown function (DUF1641)
KEF49_05870	COG2124	cytochrome p450
KEF49_05875	COG1819	glycosyl
KEF49_05885	COG1587	Uroporphyrinogen-III synthase
KEF49_05890	COG0390	transport system, permease component
KEF49_05895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KEF49_05900	COG0697	spore germination
KEF49_05905	COG4297	protein containing double-stranded beta helix domain
KEF49_05915	COG1252	NADH dehydrogenase
KEF49_05925	COG1609	Transcriptional regulator
KEF49_05935	COG0730	response to heat
KEF49_05940	COG2318	DinB family
KEF49_05945	COG0457	Tetratricopeptide repeat
KEF49_05955	COG1388	LysM domain
KEF49_05955	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_05955	COG5632	N-Acetylmuramoyl-L-alanine amidase
KEF49_05965	COG4195	phage-related replication protein
KEF49_05970	COG2856	Zn peptidase
KEF49_05975	COG1396	sequence-specific DNA binding
KEF49_05985	COG1522	sequence-specific DNA binding
KEF49_05990	COG1484	DNA-dependent DNA replication
KEF49_06010	COG1595	DNA-templated transcription, initiation
KEF49_06015	COG3728	DNA packaging
KEF49_06015	COG5484	DNA packaging
KEF49_06020	COG1783	phage Terminase large subunit
KEF49_06025	COG5518	Phage portal protein
KEF49_06030	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KEF49_06035	COG4653	Phage capsid family
KEF49_06085	COG5412	phage tail tape measure protein
KEF49_06085	COG3953	SLT domain
KEF49_06085	COG5412	phage tail tape measure protein
KEF49_06085	COG3953	SLT domain
KEF49_06090	COG1652	LysM domain
KEF49_06095	COG4193	domain, Protein
KEF49_06105	COG3628	GPW Gp25 family protein
KEF49_06110	COG3299	homolog of phage Mu protein gp47
KEF49_06115	COG3778	Protein conserved in bacteria
KEF49_06155	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_06155	COG5632	N-Acetylmuramoyl-L-alanine amidase
KEF49_06170	COG0306	phosphate transporter
KEF49_06175	COG1392	Phosphate transport regulator
KEF49_06180	COG0531	amino acid
KEF49_06185	COG0346	lactoylglutathione lyase activity
KEF49_06190	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KEF49_06195	COG0463	Glycosyl transferase, family 2
KEF49_06205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KEF49_06210	COG0477	Major facilitator Superfamily
KEF49_06215	COG2362	D-Aminopeptidase
KEF49_06220	COG0601	transmembrane transport
KEF49_06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KEF49_06230	COG0444	Belongs to the ABC transporter superfamily
KEF49_06235	COG4166	transmembrane transport
KEF49_06240	COG1619	proteins homologs of microcin C7 resistance protein MccF
KEF49_06245	COG4948	Mandelate Racemase Muconate Lactonizing
KEF49_06250	COG0791	NLP P60 protein
KEF49_06255	COG4608	Belongs to the ABC transporter superfamily
KEF49_06260	COG2706	6-phosphogluconolactonase activity
KEF49_06265	COG1834	amidinotransferase
KEF49_06270	COG1607	acyl-coa hydrolase
KEF49_06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KEF49_06280	COG2076	Multidrug Resistance protein
KEF49_06285	COG2076	Multidrug Resistance protein
KEF49_06290	COG0788	formyltetrahydrofolate deformylase activity
KEF49_06295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KEF49_06305	COG1764	response to oxidative stress
KEF49_06310	COG1846	Transcriptional regulator
KEF49_06315	COG1764	response to oxidative stress
KEF49_06330	COG0463	Glycosyl transferase, family 2
KEF49_06330	COG0457	Tetratricopeptide repeat
KEF49_06340	COG2814	Major facilitator Superfamily
KEF49_06345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KEF49_06355	COG1404	Belongs to the peptidase S8 family
KEF49_06360	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_06365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KEF49_06370	COG1122	ATPase activity
KEF49_06375	COG4721	ABC-type cobalt transport system, permease component
KEF49_06380	COG1388	LysM domain
KEF49_06380	COG3858	chitin binding
KEF49_06390	COG2239	Acts as a magnesium transporter
KEF49_06395	COG0789	Transcriptional regulator
KEF49_06410	COG1846	Transcriptional regulator
KEF49_06415	COG0726	polysaccharide deacetylase
KEF49_06420	COG1793	dna ligase
KEF49_06420	COG3285	dna ligase
KEF49_06425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KEF49_06430	COG5001	Diguanylate cyclase
KEF49_06430	COG3300	MHYT domain
KEF49_06435	COG0586	Pfam SNARE associated Golgi protein
KEF49_06440	COG0861	Integral membrane protein TerC family
KEF49_06445	COG1191	sigma factor activity
KEF49_06470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KEF49_06475	COG2323	membrane
KEF49_06485	COG3594	Acyltransferase
KEF49_06490	COG5002	protein histidine kinase activity
KEF49_06495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KEF49_06510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KEF49_06515	COG0436	Aminotransferase
KEF49_06545	COG3852	Histidine kinase
KEF49_06550	COG1846	Transcriptional regulator
KEF49_06555	COG1360	Flagellar Motor Protein
KEF49_06560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KEF49_06565	COG0542	response to heat
KEF49_06570	COG3949	Membrane
KEF49_06585	COG0720	synthase
KEF49_06590	COG0602	queuosine metabolic process
KEF49_06605	COG4873	Protein conserved in bacteria
KEF49_06615	COG3773	Cell wall hydrolase
KEF49_06620	COG2244	polysaccharide biosynthetic process
KEF49_06625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_06630	COG2217	Heavy metal translocating P-type atpase
KEF49_06635	COG0006	proline dipeptidase activity
KEF49_06640	COG1609	Transcriptional regulator
KEF49_06645	COG3711	transcriptional antiterminator
KEF49_06650	COG2190	(PTS) system
KEF49_06650	COG1263	PTS System
KEF49_06650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_06655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_06660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KEF49_06670	COG1533	DNA photolyase activity
KEF49_06675	COG0840	transmembrane signaling receptor activity
KEF49_06680	COG2084	Dehydrogenase
KEF49_06685	COG2340	Cysteine-rich secretory protein family
KEF49_06690	COG0768	penicillin binding
KEF49_06695	COG4191	Histidine kinase
KEF49_06700	COG0436	Aminotransferase
KEF49_06710	COG0784	Response regulator, receiver
KEF49_06710	COG0835	chemotaxis
KEF49_06720	COG2814	Major facilitator Superfamily
KEF49_06725	COG1376	ErfK ybiS ycfS ynhG family protein
KEF49_06730	COG1408	metallophosphoesterase
KEF49_06735	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_06745	COG2200	EAL domain
KEF49_06750	COG4703	Protein of unknown function (DUF1797)
KEF49_06755	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KEF49_06765	COG0517	IMP dehydrogenase activity
KEF49_06770	COG0583	DNA-binding transcription factor activity
KEF49_06775	COG0716	FMN binding
KEF49_06785	COG0716	FMN binding
KEF49_06805	COG0668	transmembrane transport
KEF49_06810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_06830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KEF49_06835	COG0303	'Molybdopterin
KEF49_06840	COG1763	Mo-molybdopterin cofactor biosynthetic process
KEF49_06845	COG0314	molybdopterin synthase activity
KEF49_06850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KEF49_06860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KEF49_06865	COG1136	(ABC) transporter
KEF49_06870	COG0577	efflux transmembrane transporter activity
KEF49_06875	COG1349	DNA-binding transcription factor activity
KEF49_06880	COG1105	Belongs to the carbohydrate kinase PfkB family
KEF49_06885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KEF49_06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_06885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KEF49_06890	COG0681	Belongs to the peptidase S26 family
KEF49_06900	COG0488	(ABC) transporter
KEF49_06905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KEF49_06910	COG2309	aminopeptidase activity
KEF49_06920	COG1077	Cell shape determining protein MreB Mrl
KEF49_06925	COG2002	toxin-antitoxin pair type II binding
KEF49_06930	COG3852	Histidine kinase
KEF49_06935	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KEF49_06935	COG2105	PFAM AIG2 family protein
KEF49_06940	COG0569	domain protein
KEF49_06950	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KEF49_06960	COG0561	phosphatase activity
KEF49_06965	COG0242	peptide deformylase activity
KEF49_06975	COG0497	DNA recombination
KEF49_06980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KEF49_06985	COG0022	dehydrogenase e1 component
KEF49_06990	COG0508	dehydrogenase complex catalyzes the overall conversion of
KEF49_06995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KEF49_07000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_07015	COG1982	Orn Lys Arg decarboxylase major
KEF49_07035	COG0483	inositol monophosphate 1-phosphatase activity
KEF49_07045	COG3227	Zinc metalloprotease (Elastase)
KEF49_07070	COG1217	gtp-binding protein TYPA
KEF49_07080	COG4896	Protein conserved in bacteria
KEF49_07090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KEF49_07095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KEF49_07100	COG2066	Belongs to the glutaminase family
KEF49_07110	COG0772	Belongs to the SEDS family
KEF49_07115	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KEF49_07130	COG2010	Cytochrome c
KEF49_07130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KEF49_07135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KEF49_07140	COG1845	cytochrome c oxidase, subunit III
KEF49_07145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KEF49_07150	COG3336	cytochrome c oxidase
KEF49_07160	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KEF49_07165	COG2340	Cysteine-rich secretory protein family
KEF49_07180	COG3679	Belongs to the UPF0342 family
KEF49_07190	COG0742	ribosomal rna small subunit methyltransferase
KEF49_07200	COG3314	Sporulation integral membrane protein YlbJ
KEF49_07205	COG1752	Esterase of the alpha-beta hydrolase superfamily
KEF49_07210	COG3480	Lon protease (S16) C-terminal proteolytic domain
KEF49_07220	COG1399	metal-binding, possibly nucleic acid-binding protein
KEF49_07240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KEF49_07260	COG4839	cell division protein FtsL
KEF49_07265	COG0768	penicillin binding
KEF49_07270	COG0768	penicillin binding
KEF49_07290	COG0772	Belongs to the SEDS family
KEF49_07305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KEF49_07310	COG0849	cell division
KEF49_07315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KEF49_07330	COG1191	sigma factor activity
KEF49_07335	COG1191	sigma factor activity
KEF49_07340	COG1119	ATPase activity
KEF49_07345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KEF49_07350	COG1873	PFAM PRC-barrel domain
KEF49_07355	COG1496	oxidoreductase activity
KEF49_07360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KEF49_07370	COG0762	integral membrane protein
KEF49_07375	COG2302	S4 RNA-binding domain
KEF49_07380	COG3599	regulation of cell shape
KEF49_07385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KEF49_07390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KEF49_07400	COG0564	pseudouridine synthase activity
KEF49_07410	COG2233	PERMEase
KEF49_07420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KEF49_07425	COG0505	Belongs to the CarA family
KEF49_07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KEF49_07445	COG0284	orotidine-5'-phosphate decarboxylase activity
KEF49_07450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KEF49_07460	COG0306	phosphate transporter
KEF49_07475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KEF49_07480	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KEF49_07485	COG1648	precorrin-2 dehydrogenase activity
KEF49_07500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KEF49_07505	COG1561	YicC-like family, N-terminal region
KEF49_07515	COG0194	GDP metabolic process
KEF49_07525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KEF49_07530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KEF49_07535	COG0242	peptide deformylase activity
KEF49_07545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KEF49_07545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KEF49_07555	COG0631	protein serine/threonine phosphatase activity
KEF49_07560	COG0515	serine threonine protein kinase
KEF49_07560	COG2815	serine threonine protein kinase
KEF49_07570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KEF49_07575	COG1564	THIamine pyrophosphokinase
KEF49_07590	COG1302	Protein conserved in bacteria
KEF49_07595	COG1461	Dihydroxyacetone kinase
KEF49_07600	COG1760	l-serine dehydratase
KEF49_07605	COG1760	l-serine dehydratase
KEF49_07610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KEF49_07625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KEF49_07630	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_07645	COG1196	nuclear chromosome segregation
KEF49_07650	COG0552	protein localization to endoplasmic reticulum
KEF49_07660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KEF49_07670	COG1837	Belongs to the UPF0109 family
KEF49_07695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KEF49_07710	COG2257	FlhB HrpN YscU SpaS Family
KEF49_07720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KEF49_07725	COG0758	DNA mediated transformation
KEF49_07730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KEF49_07740	COG4974	Belongs to the 'phage' integrase family
KEF49_07760	COG1815	bacterial-type flagellum-dependent cell motility
KEF49_07765	COG1558	bacterial-type flagellum-dependent cell motility
KEF49_07770	COG1677	Flagellar hook-basal body complex protein FliE
KEF49_07775	COG1766	The M ring may be actively involved in energy transduction
KEF49_07780	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KEF49_07785	COG1317	bacterial-type flagellum organization
KEF49_07790	COG1157	protein secretion by the type III secretion system
KEF49_07795	COG2882	bacterial-type flagellum organization
KEF49_07800	COG3334	PFAM MgtE intracellular
KEF49_07805	COG3144	bacterial-type flagellum assembly
KEF49_07810	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KEF49_07815	COG4786	Flagellar basal body rod
KEF49_07820	COG1582	Flagellar protein (FlbD)
KEF49_07825	COG1580	Controls the rotational direction of flagella during chemotaxis
KEF49_07830	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KEF49_07835	COG1776	CheC inhibitor of MCP methylation
KEF49_07835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KEF49_07840	COG2201	protein-glutamate methylesterase activity
KEF49_07845	COG3190	flagellar
KEF49_07850	COG1338	Plays a role in the flagellum-specific transport system
KEF49_07855	COG1987	bacterial-type flagellum assembly
KEF49_07860	COG1684	flagellar biosynthetic protein fliR
KEF49_07865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KEF49_07870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KEF49_07875	COG1419	protein localization to endoplasmic reticulum
KEF49_07880	COG0455	bacterial-type flagellum organization
KEF49_07885	COG2201	protein-glutamate methylesterase activity
KEF49_07890	COG0643	Histidine kinase
KEF49_07890	COG2198	Histidine kinase
KEF49_07895	COG0835	chemotaxis
KEF49_07900	COG1776	CheC inhibitor of MCP methylation
KEF49_07910	COG1191	sigma factor activity
KEF49_07940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KEF49_07945	COG4589	Belongs to the CDS family
KEF49_07955	COG0750	zinc metalloprotease
KEF49_07965	COG2176	DNA-directed DNA polymerase activity
KEF49_07975	COG0195	Participates in both transcription termination and antitermination
KEF49_07980	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KEF49_07985	COG1358	cellular component organization or biogenesis
KEF49_07995	COG1550	Protein conserved in bacteria
KEF49_08010	COG0196	riboflavin kinase activity
KEF49_08025	COG0726	polysaccharide deacetylase
KEF49_08030	COG0612	Peptidase, M16
KEF49_08035	COG1873	PFAM PRC-barrel domain
KEF49_08040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KEF49_08045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KEF49_08050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KEF49_08055	COG0527	aspartate kinase activity
KEF49_08065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KEF49_08070	COG0740	serine-type endopeptidase activity
KEF49_08080	COG4980	gas vesicle protein
KEF49_08080	COG1674	ftsk spoiiie
KEF49_08085	COG2188	Transcriptional regulator
KEF49_08090	COG2814	Major facilitator Superfamily
KEF49_08095	COG1846	Transcriptional regulator
KEF49_08100	COG1033	growth of symbiont in host cell
KEF49_08100	COG2409	Drug exporters of the RND superfamily
KEF49_08105	COG0612	Peptidase, M16
KEF49_08110	COG0612	Peptidase, M16
KEF49_08115	COG0300	oxidoreductase activity
KEF49_08130	COG1426	Protein conserved in bacteria
KEF49_08135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KEF49_08150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KEF49_08160	COG1692	metallophosphoesterase
KEF49_08165	COG2359	stage V sporulation protein S
KEF49_08185	COG4550	Control of competence regulator ComK, YlbF/YmcA
KEF49_08205	COG4974	Belongs to the 'phage' integrase family
KEF49_08235	COG0346	lactoylglutathione lyase activity
KEF49_08245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KEF49_08280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KEF49_08285	COG3425	synthase
KEF49_08290	COG1024	Enoyl-CoA hydratase
KEF49_08295	COG1024	Enoyl-CoA hydratase
KEF49_08300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_08300	COG0300	oxidoreductase activity
KEF49_08300	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_08300	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_08300	COG3321	synthase
KEF49_08305	COG3321	synthase
KEF49_08305	COG4221	oxidoreductase activity
KEF49_08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KEF49_08305	COG0300	oxidoreductase activity
KEF49_08310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_08310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KEF49_08310	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_08310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_08310	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_08310	COG3321	synthase
KEF49_08310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KEF49_08310	COG3321	synthase
KEF49_08310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KEF49_08310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KEF49_08315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_08315	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_08315	COG3321	synthase
KEF49_08315	COG4221	oxidoreductase activity
KEF49_08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KEF49_08320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KEF49_08320	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KEF49_08320	COG3321	synthase
KEF49_08325	COG2124	cytochrome p450
KEF49_08330	COG3209	COG3209 Rhs family protein
KEF49_08335	COG3619	membrane
KEF49_08345	COG1404	Belongs to the peptidase S8 family
KEF49_08355	COG4195	phage-related replication protein
KEF49_08360	COG1764	response to oxidative stress
KEF49_08370	COG2076	Multidrug Resistance protein
KEF49_08410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KEF49_08415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KEF49_08420	COG4112	unkown
KEF49_08425	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_08430	COG0464	growth
KEF49_08435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KEF49_08440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KEF49_08445	COG0789	Transcriptional regulator
KEF49_08450	COG0174	glutamine synthetase
KEF49_08455	COG0726	polysaccharide deacetylase
KEF49_08460	COG2124	cytochrome p450
KEF49_08465	COG2211	Major facilitator Superfamily
KEF49_08470	COG3507	Belongs to the glycosyl hydrolase 43 family
KEF49_08485	COG1070	Carbohydrate kinase
KEF49_08495	COG0574	Belongs to the PEP-utilizing enzyme family
KEF49_08495	COG3848	Pyruvate phosphate dikinase
KEF49_08505	COG1063	alcohol dehydrogenase
KEF49_08515	COG0457	Tetratricopeptide repeat
KEF49_08530	COG2318	DinB family
KEF49_08535	COG1064	alcohol dehydrogenase
KEF49_08575	COG3397	chitin binding
KEF49_08595	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_08600	COG2314	TM2 domain
KEF49_08605	COG0756	dUTP diphosphatase activity
KEF49_08610	COG4195	phage-related replication protein
KEF49_08645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KEF49_08655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KEF49_08675	COG0785	Cytochrome C biogenesis protein
KEF49_08680	COG2201	protein-glutamate methylesterase activity
KEF49_08685	COG4846	Membrane protein involved in cytochrome C biogenesis
KEF49_08695	COG0071	Belongs to the small heat shock protein (HSP20) family
KEF49_08710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KEF49_08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_08735	COG0824	Thioesterase
KEF49_08745	COG4841	protein insertion into membrane
KEF49_08755	COG1832	CoA-binding protein
KEF49_08760	COG0187	DNA topoisomerase II activity
KEF49_08765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KEF49_08775	COG1115	amino acid carrier protein
KEF49_08810	COG2205	protein histidine kinase activity
KEF49_08815	COG0745	RESPONSE REGULATOR receiver
KEF49_08825	COG3507	Belongs to the glycosyl hydrolase 43 family
KEF49_08850	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_08855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KEF49_08860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KEF49_08865	COG2124	cytochrome p450
KEF49_08885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KEF49_08895	COG2246	polysaccharide biosynthetic process
KEF49_08905	COG0586	Pfam SNARE associated Golgi protein
KEF49_08910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KEF49_08915	COG1024	Enoyl-CoA hydratase
KEF49_08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KEF49_08925	COG0511	ligase activity, forming carbon-carbon bonds
KEF49_08930	COG0439	Biotin carboxylase
KEF49_08935	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_08940	COG1960	acyl-CoA dehydrogenase activity
KEF49_08945	COG1649	PFAM Uncharacterised BCR, COG1649
KEF49_08970	COG2027	D-alanyl-D-alanine carboxypeptidase
KEF49_08975	COG2017	converts alpha-aldose to the beta-anomer
KEF49_08980	COG0534	Mate efflux family protein
KEF49_08995	COG0582	viral genome integration into host DNA
KEF49_09000	COG0166	Belongs to the GPI family
KEF49_09005	COG0405	Gamma-glutamyltransferase
KEF49_09010	COG2814	Major facilitator Superfamily
KEF49_09015	COG0640	Transcriptional regulator
KEF49_09020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KEF49_09030	COG0604	alcohol dehydrogenase
KEF49_09040	COG0493	'glutamate synthase
KEF49_09045	COG0070	glutamate synthase
KEF49_09045	COG0069	glutamate synthase activity
KEF49_09045	COG0067	glutamate synthase
KEF49_09050	COG0583	DNA-binding transcription factor activity
KEF49_09055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KEF49_09070	COG0300	oxidoreductase activity
KEF49_09075	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KEF49_09085	COG1136	(ABC) transporter
KEF49_09085	COG0577	efflux transmembrane transporter activity
KEF49_09090	COG1136	(ABC) transporter
KEF49_09095	COG3850	Histidine kinase
KEF49_09095	COG5002	protein histidine kinase activity
KEF49_09100	COG2814	Major facilitator Superfamily
KEF49_09105	COG1070	Carbohydrate kinase
KEF49_09110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KEF49_09115	COG0243	molybdopterin cofactor binding
KEF49_09130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KEF49_09135	COG0662	Cupin 2, conserved barrel domain protein
KEF49_09135	COG2207	Transcriptional regulator
KEF49_09140	COG1309	transcriptional regulator
KEF49_09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_09155	COG0640	Transcriptional regulator
KEF49_09160	COG0741	lytic transglycosylase activity
KEF49_09165	COG2322	membrane
KEF49_09180	COG1619	proteins homologs of microcin C7 resistance protein MccF
KEF49_09190	COG1388	LysM domain
KEF49_09190	COG3584	3D domain protein
KEF49_09195	COG0514	ATP-dependent DNA helicase (RecQ)
KEF49_09205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KEF49_09210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KEF49_09225	COG0071	Belongs to the small heat shock protein (HSP20) family
KEF49_09250	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_09255	COG1657	PFAM Prenyltransferase squalene oxidase
KEF49_09260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KEF49_09265	COG0733	neurotransmitter:sodium symporter activity
KEF49_09270	COG0385	Bile acid
KEF49_09275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_09280	COG0508	dehydrogenase complex catalyzes the overall conversion of
KEF49_09290	COG4548	von Willebrand factor, type A
KEF49_09295	COG0714	Associated with various cellular activities
KEF49_09300	COG2032	superoxide dismutase activity
KEF49_09305	COG0791	NLP P60 protein
KEF49_09305	COG1388	LysM domain
KEF49_09310	COG1819	glycosyl
KEF49_09315	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KEF49_09320	COG0534	Mate efflux family protein
KEF49_09325	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_09330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KEF49_09335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KEF49_09345	COG2962	Rard protein
KEF49_09360	COG1942	4-Oxalocrotonate Tautomerase
KEF49_09365	COG1733	regulation of RNA biosynthetic process
KEF49_09370	COG0778	Nitroreductase
KEF49_09375	COG0400	carboxylic ester hydrolase activity
KEF49_09380	COG0346	lactoylglutathione lyase activity
KEF49_09390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KEF49_09400	COG2723	6-phospho-beta-galactosidase activity
KEF49_09405	COG2188	Transcriptional regulator
KEF49_09410	COG0793	Belongs to the peptidase S41A family
KEF49_09410	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_09415	COG2226	methyltransferase
KEF49_09425	COG1876	peptidase activity
KEF49_09445	COG0671	phosphoesterase, PA-phosphatase related
KEF49_09465	COG0346	lactoylglutathione lyase activity
KEF49_09480	COG1509	lysine 2,3-aminomutase activity
KEF49_09485	COG0456	acetyltransferase
KEF49_09490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KEF49_09495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KEF49_09500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KEF49_09505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KEF49_09515	COG0456	acetyltransferase
KEF49_09520	COG0463	Glycosyl transferase, family 2
KEF49_09535	COG4641	Protein conserved in bacteria
KEF49_09545	COG1086	Polysaccharide biosynthesis protein
KEF49_09570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KEF49_09575	COG1086	Polysaccharide biosynthesis protein
KEF49_09590	COG1846	Transcriptional regulator
KEF49_09595	COG4698	Protein conserved in bacteria
KEF49_09600	COG2755	lipolytic protein G-D-S-L family
KEF49_09605	COG1999	signal sequence binding
KEF49_09615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KEF49_09620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KEF49_09625	COG1272	protein, Hemolysin III
KEF49_09630	COG0204	Acyl-transferase
KEF49_09635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KEF49_09650	COG2136	Putative SAM-dependent methyltransferase
KEF49_09650	COG2521	methyltransferase
KEF49_09665	COG1413	lyase activity
KEF49_09670	COG1418	mRNA catabolic process
KEF49_09675	COG0386	Belongs to the glutathione peroxidase family
KEF49_09685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KEF49_09695	COG1278	Cold shock
KEF49_09715	COG0328	RNA-DNA hybrid ribonuclease activity
KEF49_09720	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KEF49_09725	COG0328	RNA-DNA hybrid ribonuclease activity
KEF49_09735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KEF49_09750	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KEF49_09760	COG1755	Isoprenylcysteine carboxyl methyltransferase
KEF49_09765	COG3424	synthase
KEF49_09790	COG0438	transferase activity, transferring glycosyl groups
KEF49_09805	COG4824	toxin secretion phage lysis holin
KEF49_09825	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_09830	COG1705	Flagellar rod assembly protein muramidase FlgJ
KEF49_09840	COG5280	Phage tail tape measure protein TP901
KEF49_09840	COG3953	SLT domain
KEF49_09945	COG1595	DNA-templated transcription, initiation
KEF49_09970	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
KEF49_09975	COG1484	DNA-dependent DNA replication
KEF49_09980	COG3935	DnaD domain protein
KEF49_10030	COG3620	sequence-specific DNA binding
KEF49_10035	COG0582	viral genome integration into host DNA
KEF49_10040	COG2233	PERMEase
KEF49_10050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KEF49_10055	COG1199	ATP-dependent helicase activity
KEF49_10070	COG0116	Belongs to the methyltransferase superfamily
KEF49_10100	COG3359	exonuclease
KEF49_10130	COG1674	ftsk spoiiie
KEF49_10150	COG0457	Tetratricopeptide repeat
KEF49_10175	COG5444	nuclease activity
KEF49_10185	COG5632	N-Acetylmuramoyl-L-alanine amidase
KEF49_10185	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_10215	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_10230	COG5280	Phage tail tape measure protein TP901
KEF49_10230	COG3953	SLT domain
KEF49_10280	COG0740	serine-type endopeptidase activity
KEF49_10345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KEF49_10350	COG3420	alginic acid biosynthetic process
KEF49_10350	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_10355	COG4195	phage-related replication protein
KEF49_10435	COG3584	3D domain protein
KEF49_10455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KEF49_10455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KEF49_10460	COG1191	sigma factor activity
KEF49_10545	COG3620	sequence-specific DNA binding
KEF49_10550	COG3620	sequence-specific DNA binding
KEF49_10565	COG2190	(PTS) system
KEF49_10570	COG0071	Belongs to the small heat shock protein (HSP20) family
KEF49_10610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KEF49_10610	COG4499	WXG100 protein secretion system (Wss), protein YukC
KEF49_10620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KEF49_10625	COG3935	DnaD domain protein
KEF49_10635	COG0436	Aminotransferase
KEF49_10640	COG5353	protein conserved in bacteria
KEF49_10650	COG1199	ATP-dependent helicase activity
KEF49_10650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KEF49_10680	COG0438	transferase activity, transferring glycosyl groups
KEF49_10685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KEF49_10700	COG1694	Mazg nucleotide pyrophosphohydrolase
KEF49_10705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_10710	COG2140	Oxalate decarboxylase
KEF49_10720	COG4347	Protein of unknown function (DUF1405)
KEF49_10725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KEF49_10725	COG2010	Cytochrome c
KEF49_10730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KEF49_10735	COG0723	plastoquinol--plastocyanin reductase activity
KEF49_10750	COG0457	Tetratricopeptide repeat
KEF49_10760	COG0287	Prephenate dehydrogenase
KEF49_10795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KEF49_10800	COG4401	Chorismate mutase type I
KEF49_10815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KEF49_10820	COG0105	UTP biosynthetic process
KEF49_10825	COG0142	geranyltranstransferase activity
KEF49_10835	COG0142	geranyltranstransferase activity
KEF49_10850	COG0776	regulation of translation
KEF49_10855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KEF49_10895	COG0539	negative regulation of cytoplasmic translation
KEF49_10910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KEF49_10915	COG2959	enzyme of heme biosynthesis
KEF49_10920	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_10920	COG3773	Cell wall hydrolase
KEF49_10925	COG2339	peptidase activity
KEF49_10930	COG0492	ferredoxin-NADP+ reductase activity
KEF49_10935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KEF49_10940	COG4862	establishment of competence for transformation
KEF49_10945	COG1408	metallophosphoesterase
KEF49_10955	COG1388	LysM domain
KEF49_10960	COG1266	CAAX protease self-immunity
KEF49_10965	COG0514	ATP-dependent DNA helicase (RecQ)
KEF49_10970	COG4955	Helix-turn-helix domain
KEF49_10975	COG1141	Ferredoxin
KEF49_10980	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KEF49_10985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KEF49_10995	COG1595	DNA-templated transcription, initiation
KEF49_11000	COG5002	protein histidine kinase activity
KEF49_11005	COG0745	RESPONSE REGULATOR receiver
KEF49_11010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KEF49_11015	COG1333	cytochrome c biogenesis protein
KEF49_11020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_11025	COG1187	pseudouridine synthase activity
KEF49_11030	COG0700	Nucleoside recognition
KEF49_11035	COG2715	membrane protein required for spore maturation
KEF49_11040	COG1686	Belongs to the peptidase S11 family
KEF49_11065	COG1547	Domain of unknown function (DUF309)
KEF49_11070	COG0456	acetyltransferase
KEF49_11075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KEF49_11085	COG0307	riboflavin synthase, alpha
KEF49_11090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KEF49_11090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KEF49_11100	COG0681	Belongs to the peptidase S26 family
KEF49_11110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KEF49_11115	COG4086	secreted protein
KEF49_11120	COG0019	diaminopimelate decarboxylase activity
KEF49_11125	COG0697	spore germination
KEF49_11140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KEF49_11160	COG1191	sigma factor activity
KEF49_11170	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_11175	COG1686	Belongs to the peptidase S11 family
KEF49_11180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KEF49_11185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KEF49_11190	COG4974	Belongs to the 'phage' integrase family
KEF49_11200	COG0735	belongs to the Fur family
KEF49_11205	COG1300	Membrane
KEF49_11215	COG0281	malic enzyme
KEF49_11220	COG1757	Na H antiporter
KEF49_11225	COG1027	Aspartate ammonia-lyase
KEF49_11230	COG0252	asparaginase activity
KEF49_11235	COG1396	sequence-specific DNA binding
KEF49_11240	COG1379	DNA repair
KEF49_11245	COG0494	nUDIX hydrolase
KEF49_11255	COG0667	Aldo Keto reductase
KEF49_11265	COG1073	alpha beta
KEF49_11275	COG4918	Iron-sulphur cluster biosynthesis
KEF49_11280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KEF49_11280	COG0456	acetyltransferase
KEF49_11285	COG0456	acetyltransferase
KEF49_11290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KEF49_11305	COG0628	permease
KEF49_11320	COG3048	D-serine ammonia-lyase activity
KEF49_11325	COG0300	oxidoreductase activity
KEF49_11330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_11335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KEF49_11355	COG0596	Alpha beta hydrolase
KEF49_11370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KEF49_11375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KEF49_11390	COG0706	membrane insertase activity
KEF49_11395	COG2195	Cleaves the N-terminal amino acid of tripeptides
KEF49_11400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KEF49_11405	COG0346	lactoylglutathione lyase activity
KEF49_11415	COG1376	ErfK ybiS ycfS ynhG family protein
KEF49_11420	COG4129	membrane
KEF49_11425	COG1126	abc transporter atp-binding protein
KEF49_11430	COG0765	amino acid transport
KEF49_11435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_11445	COG1597	lipid kinase activity
KEF49_11450	COG0508	dehydrogenase complex catalyzes the overall conversion of
KEF49_11455	COG0022	dehydrogenase e1 component
KEF49_11460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KEF49_11465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KEF49_11470	COG3426	butyrate kinase activity
KEF49_11475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KEF49_11480	COG0280	phosphate acetyltransferase
KEF49_11485	COG3829	transcription factor binding
KEF49_11485	COG3290	protein histidine kinase activity
KEF49_11495	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KEF49_11500	COG2079	MmgE PrpD family protein
KEF49_11505	COG0372	Belongs to the citrate synthase family
KEF49_11510	COG1960	acyl-CoA dehydrogenase activity
KEF49_11515	COG1250	3-hydroxyacyl-CoA dehydrogenase
KEF49_11520	COG0183	Belongs to the thiolase family
KEF49_11525	COG0584	glycerophosphoryl diester phosphodiesterase
KEF49_11530	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_11555	COG1902	pentaerythritol trinitrate reductase activity
KEF49_11570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KEF49_11575	COG0745	RESPONSE REGULATOR receiver
KEF49_11580	COG0750	zinc metalloprotease
KEF49_11585	COG0497	DNA recombination
KEF49_11595	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KEF49_11605	COG0142	geranyltranstransferase activity
KEF49_11615	COG1570	exodeoxyribonuclease VII activity
KEF49_11630	COG1302	Protein conserved in bacteria
KEF49_11635	COG0439	Biotin carboxylase
KEF49_11640	COG0511	ligase activity, forming carbon-carbon bonds
KEF49_11680	COG3854	ATPases associated with a variety of cellular activities
KEF49_11695	COG0006	proline dipeptidase activity
KEF49_11705	COG3872	metal-dependent enzyme
KEF49_11715	COG1752	Esterase of the alpha-beta hydrolase superfamily
KEF49_11730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KEF49_11750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KEF49_11765	COG1396	sequence-specific DNA binding
KEF49_11775	COG0681	Belongs to the peptidase S26 family
KEF49_11800	COG4940	Competence protein ComGF
KEF49_11810	COG4970	Tfp pilus assembly protein FimT
KEF49_11815	COG4537	Required for transformation and DNA binding
KEF49_11820	COG1459	type II secretion system
KEF49_11825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KEF49_11830	COG0598	Magnesium transport protein CorA
KEF49_11835	COG1253	flavin adenine dinucleotide binding
KEF49_11840	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_11850	COG1393	Belongs to the ArsC family
KEF49_11860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_11870	COG0011	TIGRFAM Protein of
KEF49_11880	COG2866	Carboxypeptidase
KEF49_11885	COG1940	carbohydrate kinase activity
KEF49_11890	COG4483	Protein conserved in bacteria
KEF49_11895	COG1757	Na H antiporter
KEF49_11905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KEF49_11920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KEF49_11925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KEF49_11930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KEF49_11935	COG0581	inorganic phosphate transmembrane transporter activity
KEF49_11940	COG0573	inorganic phosphate transmembrane transporter activity
KEF49_11945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KEF49_11950	COG0768	penicillin binding
KEF49_11955	COG0477	Major facilitator Superfamily
KEF49_11960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KEF49_11965	COG2839	Protein conserved in bacteria
KEF49_11970	COG5521	maltodextrose utilization protein MalA
KEF49_11975	COG1388	LysM domain
KEF49_11985	COG4709	membrane
KEF49_11990	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KEF49_11995	COG0735	belongs to the Fur family
KEF49_12000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_12015	COG0513	Belongs to the DEAD box helicase family
KEF49_12030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KEF49_12035	COG2384	SAM-dependent methyltransferase
KEF49_12040	COG2010	Cytochrome c
KEF49_12045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KEF49_12050	COG0358	DNA primase activity
KEF49_12065	COG0517	IMP dehydrogenase activity
KEF49_12070	COG0751	glycine-tRNA ligase activity
KEF49_12090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KEF49_12095	COG0295	cytidine deaminase activity
KEF49_12100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KEF49_12110	COG1480	7TM receptor with intracellular HD hydrolase
KEF49_12115	COG1702	phosphate starvation-inducible protein PhoH
KEF49_12120	COG0561	phosphatase activity
KEF49_12135	COG4864	UPF0365 protein
KEF49_12140	COG1030	water channel activity
KEF49_12145	COG1610	YqeY-like protein
KEF49_12155	COG1283	sodium-dependent phosphate transmembrane transporter activity
KEF49_12160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KEF49_12165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KEF49_12195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KEF49_12210	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_12225	COG1466	dna polymerase III delta subunit
KEF49_12240	COG0658	competence protein
KEF49_12240	COG2333	competence protein COMEC
KEF49_12245	COG2131	deaminase
KEF49_12250	COG1555	photosystem II stabilization
KEF49_12250	COG1596	polysaccharide export
KEF49_12255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KEF49_12260	COG2226	methyltransferase
KEF49_12265	COG0799	negative regulation of ribosome biogenesis
KEF49_12270	COG1713	HD superfamily hydrolase involved in NAD metabolism
KEF49_12280	COG1534	Rna-binding protein
KEF49_12285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KEF49_12290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KEF49_12295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KEF49_12305	COG2755	lipolytic protein G-D-S-L family
KEF49_12315	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_12315	COG5632	N-Acetylmuramoyl-L-alanine amidase
KEF49_12320	COG0398	Pfam SNARE associated Golgi protein
KEF49_12355	COG0563	adenylate kinase activity
KEF49_12380	COG2318	DinB family
KEF49_12385	COG0561	phosphatase activity
KEF49_12390	COG0561	phosphatase activity
KEF49_12400	COG1482	cell wall glycoprotein biosynthetic process
KEF49_12405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KEF49_12405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KEF49_12405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_12410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_12410	COG3711	transcriptional antiterminator
KEF49_12420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KEF49_12425	COG0583	DNA-binding transcription factor activity
KEF49_12430	COG2814	Major facilitator Superfamily
KEF49_12435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KEF49_12435	COG2124	cytochrome p450
KEF49_12440	COG1309	transcriptional regulator
KEF49_12445	COG2226	methyltransferase
KEF49_12460	COG2116	formate transmembrane transporter activity
KEF49_12465	COG5609	conserved protein (DUF2294)
KEF49_12470	COG3383	formate dehydrogenase (NAD+) activity
KEF49_12475	COG2427	Protein of unknown function (DUF1641)
KEF49_12485	COG0626	cystathionine gamma-synthase activity
KEF49_12490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KEF49_12515	COG0768	penicillin binding
KEF49_12530	COG0826	peptidase U32
KEF49_12535	COG0826	peptidase U32
KEF49_12540	COG4122	O-methyltransferase activity
KEF49_12545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KEF49_12560	COG4472	Bacterial protein of unknown function (DUF965)
KEF49_12570	COG0628	permease
KEF49_12575	COG1126	abc transporter atp-binding protein
KEF49_12580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_12585	COG0765	amino acid transport
KEF49_12590	COG0765	amino acid transport
KEF49_12605	COG3881	PFAM PRC-barrel domain
KEF49_12610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KEF49_12615	COG0457	Tetratricopeptide repeat
KEF49_12625	COG1104	cysteine desulfurase activity
KEF49_12630	COG1959	2 iron, 2 sulfur cluster binding
KEF49_12635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KEF49_12640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KEF49_12665	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_12665	COG3103	Sh3 type 3 domain protein
KEF49_12665	COG4991	sh3 domain protein
KEF49_12670	COG1490	D-aminoacyl-tRNA deacylase activity
KEF49_12675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KEF49_12685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KEF49_12685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KEF49_12690	COG5416	Lipopolysaccharide assembly protein A domain
KEF49_12695	COG0490	domain, Protein
KEF49_12700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KEF49_12700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KEF49_12710	COG2244	polysaccharide biosynthetic process
KEF49_12715	COG2323	membrane
KEF49_12725	COG1862	Preprotein translocase
KEF49_12765	COG1388	LysM domain
KEF49_12775	COG0157	Belongs to the NadC ModD family
KEF49_12780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KEF49_12785	COG1104	cysteine desulfurase activity
KEF49_12790	COG1827	regulation of RNA biosynthetic process
KEF49_12795	COG0077	Prephenate dehydratase
KEF49_12810	COG3290	protein histidine kinase activity
KEF49_12815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KEF49_12820	COG2868	ribosomal protein
KEF49_12830	COG1994	Peptidase M50
KEF49_12835	COG0739	heme binding
KEF49_12840	COG2894	cell division
KEF49_12850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KEF49_12860	COG1077	Cell shape determining protein MreB Mrl
KEF49_12880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KEF49_12885	COG0285	dihydrofolate synthase activity
KEF49_12890	COG0525	valine-tRNA ligase activity
KEF49_12900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KEF49_12905	COG1388	LysM domain
KEF49_12915	COG0113	porphobilinogen synthase activity
KEF49_12920	COG1587	Uroporphyrinogen-III synthase
KEF49_12930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KEF49_12950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KEF49_12955	COG0470	DNA polymerase III
KEF49_12955	COG1067	ATP-dependent peptidase activity
KEF49_12970	COG0457	Tetratricopeptide repeat
KEF49_12970	COG1477	protein flavinylation
KEF49_12985	COG0473	3-isopropylmalate dehydrogenase activity
KEF49_13000	COG0440	acetolactate synthase activity
KEF49_13005	COG0028	Belongs to the TPP enzyme family
KEF49_13030	COG0622	Phosphoesterase
KEF49_13035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KEF49_13045	COG5401	PFAM Sporulation and spore germination
KEF49_13055	COG1846	Transcriptional regulator
KEF49_13060	COG2197	response regulator
KEF49_13065	COG0824	Thioesterase
KEF49_13070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KEF49_13075	COG1053	succinate dehydrogenase
KEF49_13080	COG2009	succinate dehydrogenase
KEF49_13085	COG1719	4-vinyl reductase, 4VR
KEF49_13090	COG0527	aspartate kinase activity
KEF49_13100	COG3118	belongs to the thioredoxin family
KEF49_13105	COG3534	alpha-L-arabinofuranosidase
KEF49_13110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KEF49_13115	COG2086	electron transfer activity
KEF49_13120	COG1024	Enoyl-CoA hydratase
KEF49_13125	COG1309	transcriptional regulator
KEF49_13130	COG0318	PFAM AMP-dependent synthetase and ligase
KEF49_13140	COG3766	membrane
KEF49_13150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KEF49_13150	COG1796	DNA polymerase
KEF49_13155	COG1286	toxin biosynthetic process
KEF49_13170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KEF49_13170	COG0072	phenylalanine-tRNA ligase activity
KEF49_13175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KEF49_13180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KEF49_13190	COG3835	regulator
KEF49_13195	COG0277	FAD linked oxidase domain protein
KEF49_13200	COG0247	lactate metabolic process
KEF49_13205	COG1966	Carbon starvation protein
KEF49_13210	COG3534	alpha-L-arabinofuranosidase
KEF49_13215	COG0395	ABC-type sugar transport system, permease component
KEF49_13220	COG1175	transmembrane transport
KEF49_13225	COG1653	transport
KEF49_13235	COG0647	UMP catabolic process
KEF49_13240	COG0235	Class ii aldolase
KEF49_13245	COG1069	ribulokinase activity
KEF49_13250	COG2160	L-arabinose isomerase activity
KEF49_13255	COG3507	Belongs to the glycosyl hydrolase 43 family
KEF49_13260	COG1363	Peptidase, m42
KEF49_13270	COG3326	Membrane
KEF49_13275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KEF49_13280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KEF49_13285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KEF49_13290	COG1346	cytolysis
KEF49_13300	COG3279	Response regulator of the LytR AlgR family
KEF49_13305	COG3275	phosphorelay sensor kinase activity
KEF49_13310	COG1011	Hydrolase
KEF49_13325	COG0398	Pfam SNARE associated Golgi protein
KEF49_13330	COG1484	DNA-dependent DNA replication
KEF49_13335	COG3611	Membrane attachment protein
KEF49_13350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KEF49_13355	COG1733	regulation of RNA biosynthetic process
KEF49_13360	COG2814	Major facilitator Superfamily
KEF49_13365	COG0656	L-ascorbic acid biosynthetic process
KEF49_13370	COG0237	dephospho-CoA kinase activity
KEF49_13375	COG1971	Probably functions as a manganese efflux pump
KEF49_13380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KEF49_13385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KEF49_13385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KEF49_13390	COG5002	protein histidine kinase activity
KEF49_13395	COG0745	RESPONSE REGULATOR receiver
KEF49_13405	COG0538	isocitrate dehydrogenase activity
KEF49_13410	COG0372	Belongs to the citrate synthase family
KEF49_13420	COG0628	permease
KEF49_13425	COG3030	protein affecting phage T7 exclusion by the F plasmid
KEF49_13430	COG0469	pyruvate kinase activity
KEF49_13450	COG0281	malic enzyme
KEF49_13455	COG0587	DNA-directed DNA polymerase activity
KEF49_13475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KEF49_13485	COG4109	DRTGG domain
KEF49_13495	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_13510	COG0521	Mo-molybdopterin cofactor biosynthetic process
KEF49_13520	COG0827	DNA restriction-modification system
KEF49_13525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KEF49_13530	COG3874	Sporulation protein YtfJ
KEF49_13540	COG1714	RDD family
KEF49_13545	COG0616	signal peptide processing
KEF49_13550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KEF49_13555	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KEF49_13560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KEF49_13575	COG1104	cysteine desulfurase activity
KEF49_13580	COG1114	Component of the transport system for branched-chain amino acids
KEF49_13590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KEF49_13595	COG1309	transcriptional regulator
KEF49_13600	COG1956	GAF domain-containing protein
KEF49_13605	COG2199	diguanylate cyclase activity
KEF49_13605	COG2203	Gaf domain
KEF49_13615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KEF49_13615	COG1017	nitric oxide dioxygenase activity
KEF49_13640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KEF49_13645	COG1378	Sugar-specific transcriptional regulator TrmB
KEF49_13650	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KEF49_13665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KEF49_13670	COG0454	-acetyltransferase
KEF49_13675	COG0517	IMP dehydrogenase activity
KEF49_13680	COG0123	including yeast histone deacetylase and acetoin utilization protein
KEF49_13685	COG1360	Flagellar Motor Protein
KEF49_13690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KEF49_13695	COG1609	Transcriptional regulator
KEF49_13700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KEF49_13700	COG1605	Chorismate mutase
KEF49_13705	COG3118	belongs to the thioredoxin family
KEF49_13710	COG4980	gas vesicle protein
KEF49_13715	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KEF49_13725	COG1674	ftsk spoiiie
KEF49_13730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KEF49_13740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_13750	COG1363	Peptidase, m42
KEF49_13755	COG5584	Small secreted protein
KEF49_13760	COG0281	malic enzyme
KEF49_13765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KEF49_13780	COG0510	thiamine kinase activity
KEF49_13785	COG1597	lipid kinase activity
KEF49_13795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KEF49_13800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KEF49_13805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KEF49_13810	COG2252	PERMEase
KEF49_13815	COG4473	ABC transporter
KEF49_13820	COG1131	(ABC) transporter
KEF49_13825	COG1349	DNA-binding transcription factor activity
KEF49_13830	COG1187	pseudouridine synthase activity
KEF49_13835	COG2244	polysaccharide biosynthetic process
KEF49_13840	COG2081	HI0933 family
KEF49_13845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KEF49_13855	COG1609	Transcriptional regulator
KEF49_13860	COG1653	transport
KEF49_13865	COG1175	transmembrane transport
KEF49_13870	COG0395	ABC-type sugar transport system, permease component
KEF49_13875	COG1486	melibiose metabolic process
KEF49_13885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KEF49_13900	COG2202	Pas domain
KEF49_13900	COG1366	Belongs to the anti-sigma-factor antagonist family
KEF49_13905	COG2814	Major facilitator Superfamily
KEF49_13910	COG5522	Integral membrane protein (intg_mem_TP0381)
KEF49_13915	COG0577	efflux transmembrane transporter activity
KEF49_13920	COG1136	(ABC) transporter
KEF49_13925	COG2205	protein histidine kinase activity
KEF49_13930	COG0745	RESPONSE REGULATOR receiver
KEF49_13935	COG0577	efflux transmembrane transporter activity
KEF49_13940	COG1136	(ABC) transporter
KEF49_13960	COG1131	(ABC) transporter
KEF49_13965	COG1725	Transcriptional regulator
KEF49_13975	COG1242	4 iron, 4 sulfur cluster binding
KEF49_13980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KEF49_13990	COG0584	glycerophosphoryl diester phosphodiesterase
KEF49_14000	COG2267	carboxylic ester hydrolase activity
KEF49_14005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KEF49_14010	COG1113	amino acid transport
KEF49_14015	COG0367	asparagine synthase
KEF49_14035	COG1506	peptidase
KEF49_14040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KEF49_14045	COG1116	anion transmembrane transporter activity
KEF49_14050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KEF49_14055	COG0494	nUDIX hydrolase
KEF49_14060	COG4824	toxin secretion phage lysis holin
KEF49_14065	COG0783	Belongs to the Dps family
KEF49_14090	COG0288	reversible hydration of carbon dioxide
KEF49_14100	COG1271	oxidase subunit
KEF49_14105	COG1294	oxidase, subunit
KEF49_14115	COG4948	Mandelate Racemase Muconate Lactonizing
KEF49_14125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KEF49_14130	COG0596	Alpha beta hydrolase
KEF49_14140	COG1169	isochorismate synthase
KEF49_14145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KEF49_14150	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KEF49_14275	COG3859	Proton-coupled thiamine transporter YuaJ
KEF49_14280	COG2268	Band 7 protein
KEF49_14285	COG1585	Membrane protein implicated in regulation of membrane protease activity
KEF49_14290	COG2318	DinB family
KEF49_14300	COG1454	alcohol dehydrogenase
KEF49_14305	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_14310	COG1510	regulation of RNA biosynthetic process
KEF49_14320	COG0569	domain protein
KEF49_14325	COG1705	Flagellar rod assembly protein muramidase FlgJ
KEF49_14330	COG1017	nitric oxide dioxygenase activity
KEF49_14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KEF49_14370	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_14370	COG5632	N-Acetylmuramoyl-L-alanine amidase
KEF49_14370	COG1388	LysM domain
KEF49_14395	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_14405	COG1705	Flagellar rod assembly protein muramidase FlgJ
KEF49_14485	COG0582	viral genome integration into host DNA
KEF49_14500	COG1216	Glycosyl transferase, family 2
KEF49_14510	COG4195	phage-related replication protein
KEF49_14515	COG3420	alginic acid biosynthetic process
KEF49_14515	COG5434	Belongs to the glycosyl hydrolase 28 family
KEF49_14550	COG1793	dna ligase
KEF49_14570	COG1595	DNA-templated transcription, initiation
KEF49_14595	COG3584	3D domain protein
KEF49_14595	COG1388	LysM domain
KEF49_14600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KEF49_14605	COG0756	dUTP diphosphatase activity
KEF49_14615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KEF49_14625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KEF49_14630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KEF49_14635	COG1780	Probably involved in ribonucleotide reductase function
KEF49_14655	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KEF49_14730	COG3655	Transcriptional regulator
KEF49_14750	COG1484	DNA-dependent DNA replication
KEF49_14795	COG4974	Belongs to the 'phage' integrase family
KEF49_14810	COG0628	permease
KEF49_14815	COG0673	inositol 2-dehydrogenase activity
KEF49_14820	COG0693	protein deglycase activity
KEF49_14825	COG0840	transmembrane signaling receptor activity
KEF49_14830	COG0840	transmembrane signaling receptor activity
KEF49_14835	COG0840	transmembrane signaling receptor activity
KEF49_14840	COG0840	transmembrane signaling receptor activity
KEF49_14855	COG2070	2-Nitropropane dioxygenase
KEF49_14860	COG0432	Pfam Uncharacterised protein family UPF0047
KEF49_14865	COG0366	Alpha amylase catalytic
KEF49_14870	COG1253	flavin adenine dinucleotide binding
KEF49_14875	COG2738	Putative neutral zinc metallopeptidase
KEF49_14890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KEF49_14915	COG1335	isochorismatase
KEF49_14920	COG1979	alcohol dehydrogenase
KEF49_14925	COG1979	alcohol dehydrogenase
KEF49_14930	COG2155	Conserved Protein
KEF49_14935	COG1098	S1 RNA binding domain
KEF49_14940	COG0436	Aminotransferase
KEF49_14945	COG1522	sequence-specific DNA binding
KEF49_14950	COG2267	carboxylic ester hydrolase activity
KEF49_14960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KEF49_14965	COG2205	protein histidine kinase activity
KEF49_14975	COG5018	Exonuclease
KEF49_14980	COG2814	Major facilitator Superfamily
KEF49_14985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KEF49_14990	COG3011	Protein conserved in bacteria
KEF49_15000	COG3290	protein histidine kinase activity
KEF49_15005	COG4565	transcriptional regulatory protein
KEF49_15010	COG1744	ABC transporter substrate-binding protein PnrA-like
KEF49_15015	COG3845	ABC transporter
KEF49_15020	COG4603	Belongs to the binding-protein-dependent transport system permease family
KEF49_15025	COG1079	Belongs to the binding-protein-dependent transport system permease family
KEF49_15035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KEF49_15035	COG2111	Na H antiporter
KEF49_15040	COG2111	Na H antiporter
KEF49_15045	COG1006	Multisubunit Na H antiporter MnhC subunit
KEF49_15050	COG0651	ATP synthesis coupled electron transport
KEF49_15055	COG1863	multisubunit Na H antiporter MnhE subunit
KEF49_15060	COG2212	antiporter activity
KEF49_15065	COG1320	monovalent cation:proton antiporter activity
KEF49_15070	COG2050	protein possibly involved in aromatic compounds catabolism
KEF49_15075	COG2197	response regulator
KEF49_15090	COG0142	geranyltranstransferase activity
KEF49_15105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KEF49_15110	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KEF49_15115	COG1335	isochorismatase
KEF49_15120	COG5506	Protein of unknown function (DUF1694)
KEF49_15135	COG0628	permease
KEF49_15145	COG1418	mRNA catabolic process
KEF49_15150	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_15160	COG1511	domain protein
KEF49_15165	COG1674	ftsk spoiiie
KEF49_15165	COG0433	COG0433 Predicted ATPase
KEF49_15170	COG4499	WXG100 protein secretion system (Wss), protein YukC
KEF49_15175	COG5417	Belongs to the EsaB family
KEF49_15180	COG4842	Belongs to the WXG100 family
KEF49_15185	COG2508	Transcriptional regulator
KEF49_15185	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KEF49_15190	COG0686	Belongs to the AlaDH PNT family
KEF49_15195	COG5634	Uncharacterized conserved protein (DUF2278)
KEF49_15200	COG3251	PFAM MbtH domain protein
KEF49_15205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KEF49_15210	COG3433	isochorismatase activity
KEF49_15210	COG1535	isochorismatase
KEF49_15215	COG1021	2,3-dihydroxybenzoate-AMP ligase
KEF49_15220	COG1169	isochorismate synthase
KEF49_15225	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_15230	COG2819	hydrolase of the alpha beta superfamily
KEF49_15235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KEF49_15240	COG1268	BioY protein
KEF49_15245	COG2056	Na+-H+ antiporter family
KEF49_15255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KEF49_15260	COG3584	3D domain protein
KEF49_15275	COG1252	NADH dehydrogenase
KEF49_15300	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KEF49_15305	COG0316	Belongs to the HesB IscA family
KEF49_15315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KEF49_15325	COG1252	NADH dehydrogenase
KEF49_15330	COG4837	Protein of unknown function (DUF1462)
KEF49_15335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KEF49_15340	COG0823	Involved in the tonB-independent uptake of proteins
KEF49_15340	COG1506	peptidase
KEF49_15340	COG4946	Tricorn protease homolog
KEF49_15350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KEF49_15355	COG0460	homoserine dehydrogenase
KEF49_15360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KEF49_15365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KEF49_15370	COG0647	UMP catabolic process
KEF49_15375	COG2445	Protein of unknown function DUF86
KEF49_15380	COG4470	Protein conserved in bacteria
KEF49_15390	COG0739	heme binding
KEF49_15400	COG0737	Belongs to the 5'-nucleotidase family
KEF49_15405	COG0730	response to heat
KEF49_15410	COG1801	Protein of unknown function DUF72
KEF49_15425	COG2508	Transcriptional regulator
KEF49_15435	COG2814	Major facilitator Superfamily
KEF49_15440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KEF49_15445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KEF49_15450	COG2356	endonuclease I
KEF49_15455	COG3842	ATPase activity
KEF49_15460	COG2188	Transcriptional regulator
KEF49_15465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KEF49_15470	COG0395	ABC-type sugar transport system, permease component
KEF49_15475	COG1175	transmembrane transport
KEF49_15480	COG1653	transport
KEF49_15485	COG2222	sugar isomerase
KEF49_15490	COG0789	Transcriptional regulator
KEF49_15515	COG0322	excinuclease ABC activity
KEF49_15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KEF49_15535	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_15550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KEF49_15560	COG0719	Fe-S assembly protein
KEF49_15565	COG0822	iron-sulfur transferase activity
KEF49_15570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KEF49_15575	COG0719	Fe-S assembly protein
KEF49_15580	COG0396	ATPase activity
KEF49_15590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KEF49_15595	COG1464	Belongs to the NlpA lipoprotein family
KEF49_15600	COG2011	ABC-type metal ion transport system permease component
KEF49_15605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KEF49_15615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KEF49_15620	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KEF49_15635	COG1393	Belongs to the ArsC family
KEF49_15640	COG1960	acyl-CoA dehydrogenase activity
KEF49_15645	COG0183	Belongs to the thiolase family
KEF49_15650	COG1250	3-hydroxyacyl-CoA dehydrogenase
KEF49_15650	COG1024	Enoyl-CoA hydratase
KEF49_15665	COG0477	Major facilitator Superfamily
KEF49_15675	COG5577	PFAM Coat F domain
KEF49_15680	COG1846	Transcriptional regulator
KEF49_15685	COG0477	Major facilitator Superfamily
KEF49_15700	COG1120	ATPase activity
KEF49_15715	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_15720	COG0783	Belongs to the Dps family
KEF49_15725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KEF49_15730	COG0745	RESPONSE REGULATOR receiver
KEF49_15735	COG2205	protein histidine kinase activity
KEF49_15735	COG2770	Histidine kinase
KEF49_15745	COG1309	transcriptional regulator
KEF49_15750	COG0114	fumarate hydratase activity
KEF49_15760	COG0697	spore germination
KEF49_15765	COG0814	amino acid
KEF49_15775	COG2197	response regulator
KEF49_15780	COG4585	Histidine kinase
KEF49_15785	COG4758	membrane
KEF49_15790	COG3595	metallopeptidase activity
KEF49_15795	COG1842	Phage shock protein A
KEF49_15800	COG4758	membrane
KEF49_15805	COG2814	Major facilitator Superfamily
KEF49_15810	COG2096	Adenosyltransferase
KEF49_15815	COG1120	ATPase activity
KEF49_15820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_15825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KEF49_15830	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_15835	COG3386	PFAM SMP-30 Gluconolaconase
KEF49_15840	COG2205	protein histidine kinase activity
KEF49_15845	COG0745	RESPONSE REGULATOR receiver
KEF49_15855	COG1191	sigma factor activity
KEF49_15865	COG2140	Oxalate decarboxylase
KEF49_15875	COG1120	ATPase activity
KEF49_15880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_15885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_15890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KEF49_15895	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KEF49_15900	COG0531	amino acid
KEF49_15910	COG1988	membrane-bound metal-dependent
KEF49_15915	COG1368	sulfuric ester hydrolase activity
KEF49_15920	COG1910	domain protein
KEF49_15925	COG0725	ABC transporter, periplasmic molybdate-binding protein
KEF49_15930	COG4149	molybdate abc transporter
KEF49_15935	COG2197	response regulator
KEF49_15945	COG1131	(ABC) transporter
KEF49_15955	COG0842	Transport permease protein
KEF49_15960	COG0656	L-ascorbic acid biosynthetic process
KEF49_15980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KEF49_15985	COG3973	AAA domain
KEF49_15990	COG2860	membrane
KEF49_16000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KEF49_16005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KEF49_16010	COG2217	Heavy metal translocating P-type atpase
KEF49_16015	COG2217	Heavy metal translocating P-type atpase
KEF49_16020	COG2608	mercury ion transmembrane transporter activity
KEF49_16025	COG1937	Protein conserved in bacteria
KEF49_16030	COG0673	inositol 2-dehydrogenase activity
KEF49_16040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_16045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KEF49_16050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_16055	COG1126	abc transporter atp-binding protein
KEF49_16060	COG0765	amino acid transport
KEF49_16065	COG0765	amino acid transport
KEF49_16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_16075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KEF49_16080	COG0454	-acetyltransferase
KEF49_16085	COG0583	DNA-binding transcription factor activity
KEF49_16090	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_16095	COG2732	(Barnase) inhibitor
KEF49_16115	COG0557	exoribonuclease II activity
KEF49_16120	COG1647	Serine aminopeptidase, S33
KEF49_16125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KEF49_16130	COG1476	TRANSCRIPTIONal
KEF49_16135	COG1396	sequence-specific DNA binding
KEF49_16140	COG1396	sequence-specific DNA binding
KEF49_16145	COG1733	regulation of RNA biosynthetic process
KEF49_16170	COG1131	(ABC) transporter
KEF49_16175	COG1174	glycine betaine transport
KEF49_16180	COG1732	Glycine betaine
KEF49_16185	COG1174	glycine betaine transport
KEF49_16190	COG0517	IMP dehydrogenase activity
KEF49_16190	COG1125	glycine betaine transport
KEF49_16195	COG1510	regulation of RNA biosynthetic process
KEF49_16200	COG1174	glycine betaine transport
KEF49_16205	COG1732	Glycine betaine
KEF49_16210	COG1174	glycine betaine transport
KEF49_16215	COG0517	IMP dehydrogenase activity
KEF49_16215	COG1125	glycine betaine transport
KEF49_16220	COG1510	regulation of RNA biosynthetic process
KEF49_16225	COG2095	MarC family integral membrane protein
KEF49_16230	COG3064	Membrane
KEF49_16235	COG4640	response to antibiotic
KEF49_16240	COG0456	acetyltransferase
KEF49_16255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KEF49_16275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KEF49_16280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KEF49_16290	COG2234	aminopeptidase activity
KEF49_16310	COG0126	phosphoglycerate kinase activity
KEF49_16315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KEF49_16320	COG2390	Transcriptional regulator
KEF49_16325	COG2814	Major facilitator Superfamily
KEF49_16330	COG1609	Transcriptional regulator
KEF49_16335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_16340	COG0583	DNA-binding transcription factor activity
KEF49_16345	COG0697	spore germination
KEF49_16350	COG1113	amino acid transport
KEF49_16360	COG1737	Transcriptional regulator
KEF49_16365	COG1070	Carbohydrate kinase
KEF49_16390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KEF49_16395	COG2186	Transcriptional regulator
KEF49_16400	COG1620	l-lactate permease
KEF49_16405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KEF49_16415	COG5039	Polysaccharide pyruvyl transferase
KEF49_16420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KEF49_16425	COG0110	maltose O-acetyltransferase activity
KEF49_16430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KEF49_16435	COG2244	polysaccharide biosynthetic process
KEF49_16440	COG1216	Glycosyl transferase, family 2
KEF49_16445	COG5039	Polysaccharide pyruvyl transferase
KEF49_16450	COG1216	Glycosyl transferase, family 2
KEF49_16460	COG0438	transferase activity, transferring glycosyl groups
KEF49_16465	COG1215	transferase activity, transferring glycosyl groups
KEF49_16470	COG0438	transferase activity, transferring glycosyl groups
KEF49_16475	COG1086	Polysaccharide biosynthesis protein
KEF49_16480	COG0489	protein tyrosine kinase activity
KEF49_16485	COG3944	biosynthesis protein
KEF49_16490	COG1396	sequence-specific DNA binding
KEF49_16495	COG2272	Belongs to the type-B carboxylesterase lipase family
KEF49_16500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KEF49_16515	COG2364	Membrane
KEF49_16520	COG0456	acetyltransferase
KEF49_16525	COG3479	Phenolic acid decarboxylase
KEF49_16570	COG2223	nitrite transmembrane transporter activity
KEF49_16575	COG1609	Transcriptional regulator
KEF49_16590	COG1611	Belongs to the LOG family
KEF49_16595	COG1694	Mazg nucleotide pyrophosphohydrolase
KEF49_16600	COG0659	secondary active sulfate transmembrane transporter activity
KEF49_16605	COG0288	reversible hydration of carbon dioxide
KEF49_16610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KEF49_16615	COG4290	ribonuclease
KEF49_16620	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KEF49_16625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_16635	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KEF49_16645	COG1051	belongs to the nudix hydrolase family
KEF49_16650	COG0492	ferredoxin-NADP+ reductase activity
KEF49_16655	COG3883	PFAM NLP P60 protein
KEF49_16655	COG0791	NLP P60 protein
KEF49_16660	COG0457	Tetratricopeptide repeat
KEF49_16665	COG5002	protein histidine kinase activity
KEF49_16670	COG0745	RESPONSE REGULATOR receiver
KEF49_16675	COG1132	(ABC) transporter
KEF49_16680	COG0140	phosphoribosyl-ATP diphosphatase activity
KEF49_16680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KEF49_16705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KEF49_16720	COG4990	cell redox homeostasis
KEF49_16725	COG0110	maltose O-acetyltransferase activity
KEF49_16745	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KEF49_16755	COG2188	Transcriptional regulator
KEF49_16760	COG1917	Cupin 2, conserved barrel domain protein
KEF49_16765	COG1309	transcriptional regulator
KEF49_16770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KEF49_16775	COG1950	PFAM Membrane protein of
KEF49_16780	COG1983	PspC domain protein
KEF49_16785	COG3595	metallopeptidase activity
KEF49_16800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KEF49_16810	COG4897	Protein conserved in bacteria
KEF49_16815	COG3848	Pyruvate phosphate dikinase
KEF49_16815	COG0574	Belongs to the PEP-utilizing enzyme family
KEF49_16820	COG1309	transcriptional regulator
KEF49_16825	COG2814	Major facilitator Superfamily
KEF49_16835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KEF49_16845	COG0793	Belongs to the peptidase S41A family
KEF49_16845	COG3409	Peptidoglycan-binding domain 1 protein
KEF49_16850	COG3420	alginic acid biosynthetic process
KEF49_16855	COG2177	Part of the ABC transporter FtsEX involved in
KEF49_16860	COG2884	Cell division ATP-binding protein ftsE
KEF49_16865	COG2010	Cytochrome c
KEF49_16870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_16885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KEF49_16900	COG1516	flagellar protein fliS
KEF49_16905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KEF49_16910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KEF49_16930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KEF49_16935	COG1256	bacterial-type flagellum assembly
KEF49_16935	COG4786	Flagellar basal body rod
KEF49_16940	COG3418	PFAM FlgN family protein
KEF49_16945	COG2747	anti-sigma28 factor FlgM
KEF49_16955	COG1040	competence protein
KEF49_16965	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KEF49_16970	COG1307	EDD domain protein, DegV family
KEF49_16975	COG2197	response regulator
KEF49_16980	COG4585	Histidine kinase
KEF49_16985	COG1739	Uncharacterized protein family UPF0029
KEF49_16990	COG1316	TRANSCRIPTIONal
KEF49_16995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KEF49_17000	COG0438	transferase activity, transferring glycosyl groups
KEF49_17005	COG1215	transferase activity, transferring glycosyl groups
KEF49_17010	COG3206	protein involved in exopolysaccharide biosynthesis
KEF49_17015	COG3307	-O-antigen
KEF49_17020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KEF49_17025	COG0297	glycogen (starch) synthase activity
KEF49_17025	COG0438	transferase activity, transferring glycosyl groups
KEF49_17030	COG2244	polysaccharide biosynthetic process
KEF49_17040	COG0860	N-Acetylmuramoyl-L-alanine amidase
KEF49_17040	COG2247	cell wall binding repeat
KEF49_17045	COG2385	sporulation resulting in formation of a cellular spore
KEF49_17045	COG2247	cell wall binding repeat
KEF49_17055	COG1316	TRANSCRIPTIONal
KEF49_17060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KEF49_17065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KEF49_17070	COG1134	teichoic acid transport
KEF49_17075	COG1682	transport, permease protein
KEF49_17080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KEF49_17085	COG0463	Glycosyl transferase, family 2
KEF49_17090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KEF49_17095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KEF49_17100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KEF49_17105	COG4193	domain, Protein
KEF49_17110	COG1482	cell wall glycoprotein biosynthetic process
KEF49_17115	COG0697	spore germination
KEF49_17120	COG0814	amino acid
KEF49_17130	COG1215	transferase activity, transferring glycosyl groups
KEF49_17135	COG2814	Major facilitator Superfamily
KEF49_17140	COG1316	TRANSCRIPTIONal
KEF49_17145	COG0561	phosphatase activity
KEF49_17175	COG0791	NLP P60 protein
KEF49_17185	COG2843	Capsule synthesis protein
KEF49_17195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KEF49_17200	COG0697	spore germination
KEF49_17205	COG0814	amino acid
KEF49_17215	COG1609	Transcriptional regulator
KEF49_17220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KEF49_17230	COG1129	ABC transporter
KEF49_17235	COG1172	Belongs to the binding-protein-dependent transport system permease family
KEF49_17240	COG1879	ABC-type sugar transport system periplasmic component
KEF49_17245	COG3103	Sh3 type 3 domain protein
KEF49_17250	COG2249	NAD(P)H dehydrogenase (quinone) activity
KEF49_17255	COG3527	Alpha-acetolactate decarboxylase
KEF49_17260	COG0028	Belongs to the TPP enzyme family
KEF49_17265	COG0583	DNA-binding transcription factor activity
KEF49_17270	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KEF49_17285	COG5337	Spore coat protein CotH
KEF49_17290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KEF49_17295	COG0405	Gamma-glutamyltransferase
KEF49_17300	COG1522	sequence-specific DNA binding
KEF49_17305	COG2059	Chromate
KEF49_17310	COG2059	Chromate
KEF49_17360	COG5444	nuclease activity
KEF49_17375	COG3878	Protein conserved in bacteria
KEF49_17380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KEF49_17385	COG4464	protein tyrosine phosphatase activity
KEF49_17390	COG0489	protein tyrosine kinase activity
KEF49_17395	COG3944	biosynthesis protein
KEF49_17405	COG4715	Zinc finger, swim domain protein
KEF49_17410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KEF49_17415	COG0561	phosphatase activity
KEF49_17420	COG1349	DNA-binding transcription factor activity
KEF49_17425	COG0629	single-stranded DNA binding
KEF49_17450	COG0457	Tetratricopeptide repeat
KEF49_17455	COG4786	Flagellar basal body rod
KEF49_17460	COG4786	Flagellar basal body rod
KEF49_17465	COG1077	Cell shape determining protein MreB Mrl
KEF49_17470	COG1609	Transcriptional regulator
KEF49_17475	COG1846	Transcriptional regulator
KEF49_17480	COG2814	Major facilitator Superfamily
KEF49_17485	COG1953	Uracil, thiamine, allantoin
KEF49_17490	COG0477	Major facilitator Superfamily
KEF49_17495	COG1335	isochorismatase
KEF49_17500	COG0004	ammonium transporteR
KEF49_17505	COG0347	Belongs to the P(II) protein family
KEF49_17510	COG0772	Belongs to the SEDS family
KEF49_17515	COG0671	phosphoesterase, PA-phosphatase related
KEF49_17525	COG0739	heme binding
KEF49_17530	COG1247	-acetyltransferase
KEF49_17545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KEF49_17555	COG2910	NAD(P)H-binding
KEF49_17560	COG1959	2 iron, 2 sulfur cluster binding
KEF49_17575	COG0831	urea catabolic process
KEF49_17580	COG3237	CsbD-like
KEF49_17585	COG1994	Peptidase M50
KEF49_17590	COG0457	Tetratricopeptide repeat
KEF49_17600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KEF49_17610	COG2304	oxidoreductase activity
KEF49_17615	COG2304	oxidoreductase activity
KEF49_17620	COG2385	sporulation resulting in formation of a cellular spore
KEF49_17625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KEF49_17635	COG4836	Membrane
KEF49_17705	COG0698	ribose 5-phosphate isomerase
KEF49_17710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KEF49_17720	COG0009	L-threonylcarbamoyladenylate synthase
KEF49_17725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KEF49_17745	COG2890	protein-(glutamine-N5) methyltransferase activity
KEF49_17750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KEF49_17755	COG0346	lactoylglutathione lyase activity
KEF49_17760	COG0789	Transcriptional regulator
KEF49_17765	COG0679	Auxin Efflux Carrier
KEF49_17770	COG0281	malic enzyme
KEF49_17785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KEF49_17790	COG1494	fructose-1,6-bisphosphatase
KEF49_17795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KEF49_17805	COG0191	fructose-bisphosphate aldolase activity
KEF49_17810	COG2204	response regulator
KEF49_17815	COG4821	SIS domain
KEF49_17830	COG0247	lactate metabolic process
KEF49_17830	COG2181	nitrate reductase activity
KEF49_17835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KEF49_17850	COG1132	(ABC) transporter
KEF49_17855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KEF49_17860	COG2181	nitrate reductase activity
KEF49_17865	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KEF49_17870	COG1140	nitrate reductase beta subunit
KEF49_17875	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KEF49_17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KEF49_17890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KEF49_17895	COG2223	nitrite transmembrane transporter activity
KEF49_17905	COG4506	Protein conserved in bacteria
KEF49_17915	COG3391	amine dehydrogenase activity
KEF49_17920	COG0457	Tetratricopeptide repeat
KEF49_17930	COG0010	Belongs to the arginase family
KEF49_17935	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KEF49_17940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KEF49_17955	COG1994	Peptidase M50
KEF49_17960	COG1942	4-Oxalocrotonate Tautomerase
KEF49_17965	COG1846	Transcriptional regulator
KEF49_17970	COG0531	amino acid
KEF49_17975	COG3465	dGTPase activity
KEF49_17980	COG1078	dGTPase activity
KEF49_17995	COG1695	Transcriptional regulator
KEF49_18005	COG1131	(ABC) transporter
KEF49_18010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KEF49_18040	COG0583	DNA-binding transcription factor activity
KEF49_18045	COG2855	membrane
KEF49_18050	COG0280	phosphate acetyltransferase
KEF49_18060	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_18065	COG0436	Aminotransferase
KEF49_18075	COG0151	Belongs to the GarS family
KEF49_18085	COG1917	Cupin 2, conserved barrel domain protein
KEF49_18090	COG0077	Prephenate dehydratase
KEF49_18095	COG2814	Major facilitator Superfamily
KEF49_18100	COG2814	Major facilitator Superfamily
KEF49_18105	COG0833	amino acid
KEF49_18110	COG4187	Peptidase family M20/M25/M40
KEF49_18115	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_18120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KEF49_18130	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KEF49_18135	COG1091	dTDP-4-dehydrorhamnose reductase activity
KEF49_18140	COG1088	dTDP-glucose 4,6-dehydratase activity
KEF49_18145	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KEF49_18150	COG3980	spore coat polysaccharide biosynthesis protein
KEF49_18155	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KEF49_18160	COG2089	acid synthase
KEF49_18165	COG0456	acetyltransferase
KEF49_18170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KEF49_18175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KEF49_18180	COG0463	Glycosyl transferase, family 2
KEF49_18190	COG2363	Small membrane protein
KEF49_18195	COG2233	PERMEase
KEF49_18210	COG1216	Glycosyl transferase, family 2
KEF49_18215	COG0351	phosphomethylpyrimidine kinase
KEF49_18225	COG1621	beta-fructofuranosidase activity
KEF49_18230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KEF49_18230	COG1263	PTS System
KEF49_18235	COG3711	transcriptional antiterminator
KEF49_18245	COG1404	Belongs to the peptidase S8 family
KEF49_18250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KEF49_18255	COG0778	Nitroreductase
KEF49_18260	COG0772	Belongs to the SEDS family
KEF49_18265	COG0454	-acetyltransferase
KEF49_18275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KEF49_18285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KEF49_18290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KEF49_18295	COG2261	transglycosylase associated protein
KEF49_18300	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KEF49_18305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KEF49_18310	COG2246	polysaccharide biosynthetic process
KEF49_18315	COG1309	transcriptional regulator
KEF49_18335	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KEF49_18340	COG2837	iron assimilation
KEF49_18345	COG2822	iron ion transport
KEF49_18350	COG0672	)-iron permease
KEF49_18365	COG0583	DNA-binding transcription factor activity
KEF49_18375	COG1346	cytolysis
KEF49_18380	COG4895	conserved protein (DUF2196)
KEF49_18385	COG0789	Transcriptional regulator
KEF49_18390	COG5504	Zn-dependent protease
KEF49_18405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KEF49_18410	COG0346	lactoylglutathione lyase activity
KEF49_18415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KEF49_18420	COG1404	Belongs to the peptidase S8 family
KEF49_18425	COG1442	glycosyl transferase family 8
KEF49_18430	COG1846	Transcriptional regulator
KEF49_18435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KEF49_18440	COG2357	RelA SpoT domain protein
KEF49_18445	COG1575	Belongs to the MenA family. Type 1 subfamily
KEF49_18460	COG1696	Membrane protein involved in D-alanine export
KEF49_18470	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KEF49_18475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KEF49_18480	COG1486	melibiose metabolic process
KEF49_18485	COG1447	Phosphotransferase system cellobiose-specific component IIA
KEF49_18490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KEF49_18495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KEF49_18500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KEF49_18500	COG3711	transcriptional antiterminator
KEF49_18510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_18515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KEF49_18525	COG0640	Transcriptional regulator
KEF49_18530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KEF49_18535	COG0753	catalase activity
KEF49_18540	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KEF49_18545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KEF49_18550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KEF49_18555	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KEF49_18560	COG4988	ABC transporter
KEF49_18565	COG1294	oxidase, subunit
KEF49_18570	COG1271	oxidase subunit
KEF49_18575	COG3493	citrate carrier protein
KEF49_18580	COG0726	polysaccharide deacetylase
KEF49_18585	COG3842	ATPase activity
KEF49_18590	COG2508	Transcriptional regulator
KEF49_18595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_18605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KEF49_18620	COG4894	glucomannan catabolic process
KEF49_18625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KEF49_18630	COG0500	methyltransferase
KEF49_18635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KEF49_18655	COG0753	catalase activity
KEF49_18655	COG0693	protein deglycase activity
KEF49_18660	COG2851	Citrate transporter
KEF49_18665	COG2273	Hydrolase Family 16
KEF49_18675	COG2270	Major facilitator Superfamily
KEF49_18680	COG0513	Belongs to the DEAD box helicase family
KEF49_18760	COG3209	COG3209 Rhs family protein
KEF49_18770	COG0697	spore germination
KEF49_18775	COG0589	response to stress
KEF49_18790	COG0494	nUDIX hydrolase
KEF49_18795	COG3507	Belongs to the glycosyl hydrolase 43 family
KEF49_18820	COG0010	Belongs to the arginase family
KEF49_18825	COG0833	amino acid
KEF49_18830	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KEF49_18835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KEF49_18845	COG2390	Transcriptional regulator
KEF49_18850	COG0561	phosphatase activity
KEF49_18880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KEF49_18885	COG5294	Protein conserved in bacteria
KEF49_18890	COG0577	efflux transmembrane transporter activity
KEF49_18895	COG1136	(ABC) transporter
KEF49_18900	COG2205	protein histidine kinase activity
KEF49_18905	COG0745	RESPONSE REGULATOR receiver
KEF49_18920	COG1082	Xylose isomerase domain protein TIM barrel
KEF49_18930	COG2814	Major facilitator Superfamily
KEF49_18960	COG1349	DNA-binding transcription factor activity
KEF49_18965	COG0667	Aldo Keto reductase
KEF49_18970	COG2814	Major facilitator Superfamily
KEF49_18980	COG1028	Short-chain dehydrogenase reductase Sdr
KEF49_18985	COG2197	response regulator
KEF49_18990	COG4585	Histidine kinase
KEF49_18995	COG3239	Fatty acid desaturase
KEF49_19000	COG1309	transcriptional regulator
KEF49_19005	COG1012	belongs to the aldehyde dehydrogenase family
KEF49_19010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KEF49_19020	COG0640	Transcriptional regulator
KEF49_19025	COG2814	Major facilitator Superfamily
KEF49_19030	COG1714	RDD family
KEF49_19040	COG0450	alkyl hydroperoxide reductase
KEF49_19045	COG3634	alkyl hydroperoxide reductase activity
KEF49_19055	COG1113	amino acid transport
KEF49_19080	COG2080	2 iron, 2 sulfur cluster binding
KEF49_19095	COG2068	MobA-Related Protein
KEF49_19100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KEF49_19140	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
KEF49_19145	COG0667	Aldo Keto reductase
KEF49_19150	COG0456	acetyltransferase
KEF49_19155	COG0457	Tetratricopeptide repeat
KEF49_19160	COG0010	Belongs to the arginase family
KEF49_19165	COG0833	amino acid
KEF49_19170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KEF49_19175	COG3829	transcription factor binding
KEF49_19185	COG5002	protein histidine kinase activity
KEF49_19190	COG0745	RESPONSE REGULATOR receiver
KEF49_19195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KEF49_19200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KEF49_19205	COG4853	Protein conserved in bacteria
KEF49_19210	COG4863	YycH protein
KEF49_19215	COG5002	protein histidine kinase activity
KEF49_19220	COG0745	RESPONSE REGULATOR receiver
KEF49_19250	COG0346	lactoylglutathione lyase activity
KEF49_19255	COG0305	Participates in initiation and elongation during chromosome replication
KEF49_19270	COG3093	addiction module antidote protein HigA
KEF49_19275	COG0438	transferase activity, transferring glycosyl groups
KEF49_19285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KEF49_19290	COG0438	transferase activity, transferring glycosyl groups
KEF49_19310	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KEF49_19315	COG4241	membrane
KEF49_19325	COG5577	PFAM Coat F domain
KEF49_19330	COG1733	regulation of RNA biosynthetic process
KEF49_19340	COG0697	spore germination
KEF49_19345	COG1621	beta-fructofuranosidase activity
KEF49_19350	COG1621	beta-fructofuranosidase activity
KEF49_19360	COG2318	DinB family
KEF49_19370	COG0778	Nitroreductase
KEF49_19375	COG1846	Transcriptional regulator
KEF49_19380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KEF49_19385	COG1846	Transcriptional regulator
KEF49_19390	COG2153	protein acetylation
KEF49_19395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KEF49_19400	COG0697	spore germination
KEF49_19405	COG1331	Highly conserved protein containing a thioredoxin domain
KEF49_19410	COG1266	CAAX protease self-immunity
KEF49_19415	COG0477	Major facilitator Superfamily
KEF49_19415	COG2814	Major facilitator Superfamily
KEF49_19420	COG0346	lactoylglutathione lyase activity
KEF49_19425	COG1609	Transcriptional regulator
KEF49_19430	COG0708	Exodeoxyribonuclease III
KEF49_19435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KEF49_19440	COG2169	Transcriptional regulator
KEF49_19450	COG0629	single-stranded DNA binding
KEF49_19460	COG0012	GTP binding
KEF49_19465	COG0243	molybdopterin cofactor binding
KEF49_19470	COG4481	Protein conserved in bacteria
KEF49_19475	COG3949	Membrane
KEF49_19490	COG1475	DNA binding
KEF49_19495	COG1192	Involved in chromosome partitioning
KEF49_19520	COG1847	R3H domain protein
KEF49_19525	COG0706	membrane insertase activity