locus-tag	class	description
E3U39_00010	COG4282	regulation of fungal-type cell wall biogenesis
E3U39_00020	COG0174	glutamine synthetase
E3U39_00025	COG0789	Transcriptional regulator
E3U39_00030	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E3U39_00035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E3U39_00040	COG0464	growth
E3U39_00050	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_00055	COG4112	unkown
E3U39_00060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U39_00065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U39_00105	COG2076	Multidrug Resistance protein
E3U39_00115	COG1764	response to oxidative stress
E3U39_00120	COG4195	phage-related replication protein
E3U39_00130	COG1404	Belongs to the peptidase S8 family
E3U39_00140	COG3619	membrane
E3U39_00145	COG3209	COG3209 Rhs family protein
E3U39_00150	COG2124	cytochrome p450
E3U39_00155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00155	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E3U39_00155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E3U39_00155	COG3321	synthase
E3U39_00160	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_00160	COG4221	oxidoreductase activity
E3U39_00160	COG3321	synthase
E3U39_00160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_00165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_00165	COG3321	synthase
E3U39_00165	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_00165	COG3321	synthase
E3U39_00165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_00165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_00165	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_00170	COG3321	synthase
E3U39_00170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00170	COG0300	oxidoreductase activity
E3U39_00170	COG4221	oxidoreductase activity
E3U39_00175	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_00175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_00175	COG0300	oxidoreductase activity
E3U39_00175	COG3321	synthase
E3U39_00175	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_00180	COG1024	Enoyl-CoA hydratase
E3U39_00185	COG1024	Enoyl-CoA hydratase
E3U39_00190	COG3425	synthase
E3U39_00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00240	COG0582	viral genome integration into host DNA
E3U39_00265	COG4550	Control of competence regulator ComK, YlbF/YmcA
E3U39_00285	COG2359	stage V sporulation protein S
E3U39_00290	COG1692	metallophosphoesterase
E3U39_00300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3U39_00315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E3U39_00320	COG1426	Protein conserved in bacteria
E3U39_00335	COG0300	oxidoreductase activity
E3U39_00340	COG0612	Peptidase, M16
E3U39_00345	COG0612	Peptidase, M16
E3U39_00350	COG1033	growth of symbiont in host cell
E3U39_00350	COG2409	Drug exporters of the RND superfamily
E3U39_00355	COG1846	Transcriptional regulator
E3U39_00360	COG2814	Major facilitator Superfamily
E3U39_00365	COG2188	Transcriptional regulator
E3U39_00370	COG1674	ftsk spoiiie
E3U39_00370	COG4980	gas vesicle protein
E3U39_00380	COG0740	serine-type endopeptidase activity
E3U39_00385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E3U39_00395	COG0527	aspartate kinase activity
E3U39_00400	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E3U39_00405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3U39_00410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3U39_00415	COG1873	PFAM PRC-barrel domain
E3U39_00420	COG0612	Peptidase, M16
E3U39_00425	COG0726	polysaccharide deacetylase
E3U39_00440	COG0196	riboflavin kinase activity
E3U39_00455	COG1550	Protein conserved in bacteria
E3U39_00465	COG1358	cellular component organization or biogenesis
E3U39_00470	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E3U39_00475	COG0195	Participates in both transcription termination and antitermination
E3U39_00485	COG2176	DNA-directed DNA polymerase activity
E3U39_00495	COG0750	zinc metalloprotease
E3U39_00505	COG4589	Belongs to the CDS family
E3U39_00510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E3U39_00540	COG1191	sigma factor activity
E3U39_00550	COG1776	CheC inhibitor of MCP methylation
E3U39_00555	COG0835	chemotaxis
E3U39_00560	COG2198	Histidine kinase
E3U39_00560	COG0643	Histidine kinase
E3U39_00565	COG2201	protein-glutamate methylesterase activity
E3U39_00570	COG0455	bacterial-type flagellum organization
E3U39_00575	COG1419	protein localization to endoplasmic reticulum
E3U39_00580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3U39_00585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E3U39_00590	COG1684	flagellar biosynthetic protein fliR
E3U39_00595	COG1987	bacterial-type flagellum assembly
E3U39_00600	COG1338	Plays a role in the flagellum-specific transport system
E3U39_00605	COG3190	flagellar
E3U39_00610	COG2201	protein-glutamate methylesterase activity
E3U39_00615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3U39_00615	COG1776	CheC inhibitor of MCP methylation
E3U39_00620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3U39_00625	COG1580	Controls the rotational direction of flagella during chemotaxis
E3U39_00630	COG1582	Flagellar protein (FlbD)
E3U39_00635	COG4786	Flagellar basal body rod
E3U39_00640	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E3U39_00645	COG3144	bacterial-type flagellum assembly
E3U39_00650	COG3334	PFAM MgtE intracellular
E3U39_00655	COG2882	bacterial-type flagellum organization
E3U39_00660	COG1157	protein secretion by the type III secretion system
E3U39_00665	COG1317	bacterial-type flagellum organization
E3U39_00670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E3U39_00675	COG1766	The M ring may be actively involved in energy transduction
E3U39_00680	COG1677	Flagellar hook-basal body complex protein FliE
E3U39_00685	COG1558	bacterial-type flagellum-dependent cell motility
E3U39_00690	COG1815	bacterial-type flagellum-dependent cell motility
E3U39_00710	COG4974	Belongs to the 'phage' integrase family
E3U39_00720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3U39_00725	COG0758	DNA mediated transformation
E3U39_00730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E3U39_00740	COG2257	FlhB HrpN YscU SpaS Family
E3U39_00755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3U39_00780	COG1837	Belongs to the UPF0109 family
E3U39_00790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E3U39_00805	COG0552	protein localization to endoplasmic reticulum
E3U39_00810	COG1196	nuclear chromosome segregation
E3U39_00820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_00825	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_00830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3U39_00845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E3U39_00850	COG1760	l-serine dehydratase
E3U39_00855	COG1760	l-serine dehydratase
E3U39_00860	COG1461	Dihydroxyacetone kinase
E3U39_00865	COG1302	Protein conserved in bacteria
E3U39_00880	COG1564	THIamine pyrophosphokinase
E3U39_00885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E3U39_00895	COG0515	serine threonine protein kinase
E3U39_00895	COG2815	serine threonine protein kinase
E3U39_00900	COG0631	protein serine/threonine phosphatase activity
E3U39_00910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E3U39_00910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E3U39_00920	COG0242	peptide deformylase activity
E3U39_00925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3U39_00930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E3U39_00940	COG0194	GDP metabolic process
E3U39_00945	COG2052	Domain of unknown function (DUF370)
E3U39_00950	COG1561	YicC-like family, N-terminal region
E3U39_00955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E3U39_00970	COG1648	precorrin-2 dehydrogenase activity
E3U39_00975	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
E3U39_00980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3U39_00995	COG0306	phosphate transporter
E3U39_01005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E3U39_01010	COG0284	orotidine-5'-phosphate decarboxylase activity
E3U39_01025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3U39_01030	COG0505	Belongs to the CarA family
E3U39_01035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E3U39_01045	COG2233	PERMEase
E3U39_01055	COG0564	pseudouridine synthase activity
E3U39_01065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3U39_01070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E3U39_01080	COG3599	regulation of cell shape
E3U39_01085	COG2302	S4 RNA-binding domain
E3U39_01090	COG0762	integral membrane protein
E3U39_01100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E3U39_01110	COG1873	PFAM PRC-barrel domain
E3U39_01120	COG1119	ATPase activity
E3U39_01125	COG1191	sigma factor activity
E3U39_01130	COG1191	sigma factor activity
E3U39_01140	COG4412	M6 family metalloprotease domain protein
E3U39_01140	COG1404	Belongs to the peptidase S8 family
E3U39_01145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E3U39_01150	COG0849	cell division
E3U39_01155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E3U39_01170	COG0772	Belongs to the SEDS family
E3U39_01190	COG0768	penicillin binding
E3U39_01200	COG4839	cell division protein FtsL
E3U39_01220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3U39_01235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E3U39_01240	COG1399	metal-binding, possibly nucleic acid-binding protein
E3U39_01250	COG3480	Lon protease (S16) C-terminal proteolytic domain
E3U39_01255	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3U39_01260	COG3314	Sporulation integral membrane protein YlbJ
E3U39_01270	COG0742	ribosomal rna small subunit methyltransferase
E3U39_01285	COG3679	Belongs to the UPF0342 family
E3U39_01300	COG2340	Cysteine-rich secretory protein family
E3U39_01305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
E3U39_01315	COG3336	cytochrome c oxidase
E3U39_01320	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E3U39_01325	COG1845	cytochrome c oxidase, subunit III
E3U39_01330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U39_01335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U39_01335	COG2010	Cytochrome c
E3U39_01350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E3U39_01355	COG0772	Belongs to the SEDS family
E3U39_01365	COG2066	Belongs to the glutaminase family
E3U39_01370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3U39_01375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E3U39_01385	COG4896	Protein conserved in bacteria
E3U39_01415	COG1595	DNA-templated transcription, initiation
E3U39_01420	COG3227	Zinc metalloprotease (Elastase)
E3U39_01430	COG0483	inositol monophosphate 1-phosphatase activity
E3U39_01455	COG1982	Orn Lys Arg decarboxylase major
E3U39_01470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_01475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U39_01480	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U39_01485	COG0022	dehydrogenase e1 component
E3U39_01490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3U39_01495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3U39_01500	COG3321	synthase
E3U39_01500	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_01500	COG4221	oxidoreductase activity
E3U39_01500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_01505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_01505	COG3321	synthase
E3U39_01505	COG0300	oxidoreductase activity
E3U39_01505	COG4221	oxidoreductase activity
E3U39_01510	COG4221	oxidoreductase activity
E3U39_01510	COG3321	synthase
E3U39_01510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_01510	COG0300	oxidoreductase activity
E3U39_01515	COG0300	oxidoreductase activity
E3U39_01515	COG3321	synthase
E3U39_01515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_01515	COG4221	oxidoreductase activity
E3U39_01520	COG3321	synthase
E3U39_01520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_01520	COG4221	oxidoreductase activity
E3U39_01520	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_01525	COG4221	oxidoreductase activity
E3U39_01525	COG3321	synthase
E3U39_01525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_01525	COG0300	oxidoreductase activity
E3U39_01530	COG3321	synthase
E3U39_01530	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_01530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_01530	COG4221	oxidoreductase activity
E3U39_01545	COG0497	DNA recombination
E3U39_01555	COG0242	peptide deformylase activity
E3U39_01560	COG0561	phosphatase activity
E3U39_01570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E3U39_01580	COG0569	domain protein
E3U39_01585	COG2105	PFAM AIG2 family protein
E3U39_01585	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E3U39_01590	COG3852	Histidine kinase
E3U39_01595	COG2002	toxin-antitoxin pair type II binding
E3U39_01605	COG1077	Cell shape determining protein MreB Mrl
E3U39_01615	COG2309	aminopeptidase activity
E3U39_01620	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E3U39_01625	COG0488	(ABC) transporter
E3U39_01635	COG0681	Belongs to the peptidase S26 family
E3U39_01640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3U39_01640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_01640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3U39_01645	COG1105	Belongs to the carbohydrate kinase PfkB family
E3U39_01650	COG1349	DNA-binding transcription factor activity
E3U39_01655	COG0577	efflux transmembrane transporter activity
E3U39_01660	COG1136	(ABC) transporter
E3U39_01665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E3U39_01675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E3U39_01680	COG0314	molybdopterin synthase activity
E3U39_01685	COG1763	Mo-molybdopterin cofactor biosynthetic process
E3U39_01690	COG0303	'Molybdopterin
E3U39_01695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3U39_01715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_01720	COG0668	transmembrane transport
E3U39_01740	COG0716	FMN binding
E3U39_01750	COG0716	FMN binding
E3U39_01755	COG0583	DNA-binding transcription factor activity
E3U39_01760	COG0517	IMP dehydrogenase activity
E3U39_01770	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
E3U39_01775	COG4703	Protein of unknown function (DUF1797)
E3U39_01780	COG2200	EAL domain
E3U39_01790	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_01795	COG1408	metallophosphoesterase
E3U39_01800	COG1376	ErfK ybiS ycfS ynhG family protein
E3U39_01805	COG2814	Major facilitator Superfamily
E3U39_01815	COG0784	Response regulator, receiver
E3U39_01815	COG0835	chemotaxis
E3U39_01825	COG0436	Aminotransferase
E3U39_01830	COG4191	Histidine kinase
E3U39_01835	COG0768	penicillin binding
E3U39_01840	COG2340	Cysteine-rich secretory protein family
E3U39_01845	COG2084	Dehydrogenase
E3U39_01850	COG0840	transmembrane signaling receptor activity
E3U39_01855	COG1533	DNA photolyase activity
E3U39_01865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E3U39_01870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_01875	COG2190	(PTS) system
E3U39_01875	COG1263	PTS System
E3U39_01875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_01880	COG3711	transcriptional antiterminator
E3U39_01885	COG1609	Transcriptional regulator
E3U39_01890	COG0006	proline dipeptidase activity
E3U39_01895	COG2217	Heavy metal translocating P-type atpase
E3U39_01900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_01905	COG2244	polysaccharide biosynthetic process
E3U39_01910	COG3773	Cell wall hydrolase
E3U39_01920	COG4873	Protein conserved in bacteria
E3U39_01935	COG3858	chitin binding
E3U39_01940	COG1388	LysM domain
E3U39_01945	COG1388	LysM domain
E3U39_01945	COG4641	Protein conserved in bacteria
E3U39_01955	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_01960	COG1733	regulation of RNA biosynthetic process
E3U39_01970	COG0602	queuosine metabolic process
E3U39_01975	COG0720	synthase
E3U39_01990	COG3949	Membrane
E3U39_02000	COG0542	response to heat
E3U39_02005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3U39_02010	COG1360	Flagellar Motor Protein
E3U39_02015	COG1846	Transcriptional regulator
E3U39_02020	COG3852	Histidine kinase
E3U39_02050	COG0436	Aminotransferase
E3U39_02055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U39_02070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3U39_02075	COG5002	protein histidine kinase activity
E3U39_02080	COG3594	Acyltransferase
E3U39_02090	COG2323	membrane
E3U39_02095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E3U39_02120	COG1191	sigma factor activity
E3U39_02125	COG0861	Integral membrane protein TerC family
E3U39_02130	COG0586	Pfam SNARE associated Golgi protein
E3U39_02135	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E3U39_02140	COG1793	dna ligase
E3U39_02140	COG3285	dna ligase
E3U39_02145	COG0726	polysaccharide deacetylase
E3U39_02150	COG1846	Transcriptional regulator
E3U39_02165	COG0789	Transcriptional regulator
E3U39_02170	COG2239	Acts as a magnesium transporter
E3U39_02190	COG3858	chitin binding
E3U39_02190	COG1388	LysM domain
E3U39_02195	COG4721	ABC-type cobalt transport system, permease component
E3U39_02200	COG1122	ATPase activity
E3U39_02205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3U39_02210	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_02215	COG1404	Belongs to the peptidase S8 family
E3U39_02230	COG2814	Major facilitator Superfamily
E3U39_02240	COG0457	Tetratricopeptide repeat
E3U39_02240	COG0463	Glycosyl transferase, family 2
E3U39_02255	COG1764	response to oxidative stress
E3U39_02260	COG1846	Transcriptional regulator
E3U39_02265	COG1764	response to oxidative stress
E3U39_02275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3U39_02280	COG0788	formyltetrahydrofolate deformylase activity
E3U39_02285	COG2076	Multidrug Resistance protein
E3U39_02290	COG2076	Multidrug Resistance protein
E3U39_02295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_02300	COG1607	acyl-coa hydrolase
E3U39_02305	COG1834	amidinotransferase
E3U39_02310	COG2706	6-phosphogluconolactonase activity
E3U39_02315	COG4608	Belongs to the ABC transporter superfamily
E3U39_02320	COG0791	NLP P60 protein
E3U39_02325	COG4948	Mandelate Racemase Muconate Lactonizing
E3U39_02330	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3U39_02335	COG4166	transmembrane transport
E3U39_02340	COG0444	Belongs to the ABC transporter superfamily
E3U39_02345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U39_02350	COG0601	transmembrane transport
E3U39_02355	COG2362	D-Aminopeptidase
E3U39_02360	COG0477	Major facilitator Superfamily
E3U39_02365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U39_02370	COG0463	Glycosyl transferase, family 2
E3U39_02375	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3U39_02380	COG0346	lactoylglutathione lyase activity
E3U39_02385	COG0531	amino acid
E3U39_02390	COG1392	Phosphate transport regulator
E3U39_02395	COG0306	phosphate transporter
E3U39_02410	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_02410	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3U39_02450	COG3778	Protein conserved in bacteria
E3U39_02455	COG3299	homolog of phage Mu protein gp47
E3U39_02460	COG3628	GPW Gp25 family protein
E3U39_02470	COG4193	domain, Protein
E3U39_02475	COG1652	LysM domain
E3U39_02480	COG3953	SLT domain
E3U39_02480	COG5412	phage tail tape measure protein
E3U39_02480	COG3953	SLT domain
E3U39_02480	COG5412	phage tail tape measure protein
E3U39_02480	COG3953	SLT domain
E3U39_02480	COG5412	phage tail tape measure protein
E3U39_02530	COG4653	Phage capsid family
E3U39_02535	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E3U39_02540	COG5518	Phage portal protein
E3U39_02545	COG1783	phage Terminase large subunit
E3U39_02550	COG5484	DNA packaging
E3U39_02550	COG3728	DNA packaging
E3U39_02555	COG1595	DNA-templated transcription, initiation
E3U39_02570	COG1484	DNA-dependent DNA replication
E3U39_02575	COG1522	sequence-specific DNA binding
E3U39_02585	COG1396	sequence-specific DNA binding
E3U39_02595	COG2856	Zn peptidase
E3U39_02600	COG3546	catalase activity
E3U39_02605	COG4195	phage-related replication protein
E3U39_02615	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3U39_02615	COG1388	LysM domain
E3U39_02615	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_02625	COG0457	Tetratricopeptide repeat
E3U39_02630	COG2318	DinB family
E3U39_02635	COG0730	response to heat
E3U39_02640	COG2721	sulfolactate sulfo-lyase activity
E3U39_02645	COG0246	Mannitol dehydrogenase
E3U39_02650	COG1609	Transcriptional regulator
E3U39_02655	COG2211	Major facilitator Superfamily
E3U39_02665	COG1252	NADH dehydrogenase
E3U39_02675	COG4297	protein containing double-stranded beta helix domain
E3U39_02680	COG0697	spore germination
E3U39_02685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U39_02690	COG0390	transport system, permease component
E3U39_02695	COG1587	Uroporphyrinogen-III synthase
E3U39_02705	COG1819	glycosyl
E3U39_02710	COG2124	cytochrome p450
E3U39_02715	COG2427	Protein of unknown function (DUF1641)
E3U39_02720	COG3383	formate dehydrogenase (NAD+) activity
E3U39_02730	COG2205	protein histidine kinase activity
E3U39_02745	COG1285	pathogenesis
E3U39_02765	COG1349	DNA-binding transcription factor activity
E3U39_02775	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3U39_02780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_02780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_02785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3U39_02790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3U39_02795	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E3U39_02805	COG1846	Transcriptional regulator
E3U39_02810	COG0477	Major facilitator Superfamily
E3U39_02815	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3U39_02820	COG2367	Beta-lactamase
E3U39_02830	COG0135	phosphoribosylanthranilate isomerase activity
E3U39_02900	COG0626	cystathionine gamma-synthase activity
E3U39_02905	COG0626	cystathionine gamma-synthase activity
E3U39_02910	COG2382	esterase
E3U39_02920	COG2153	protein acetylation
E3U39_02930	COG1131	(ABC) transporter
E3U39_02950	COG0210	DNA helicase
E3U39_03005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E3U39_03010	COG0351	phosphomethylpyrimidine kinase
E3U39_03015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3U39_03025	COG2104	thiamine diphosphate biosynthetic process
E3U39_03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U39_03035	COG0352	thiamine-phosphate diphosphorylase activity
E3U39_03040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E3U39_03045	COG0569	domain protein
E3U39_03045	COG0475	glutathione-regulated potassium exporter activity
E3U39_03060	COG0564	pseudouridine synthase activity
E3U39_03065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3U39_03070	COG2357	RelA SpoT domain protein
E3U39_03080	COG4116	CYTH
E3U39_03085	COG0741	lytic transglycosylase activity
E3U39_03090	COG2346	COG2346, Truncated hemoglobins
E3U39_03100	COG1164	Oligoendopeptidase f
E3U39_03105	COG4469	Competence protein
E3U39_03110	COG4862	establishment of competence for transformation
E3U39_03115	COG0861	Integral membrane protein TerC family
E3U39_03120	COG1393	Belongs to the ArsC family
E3U39_03125	COG0456	acetyltransferase
E3U39_03135	COG4608	Belongs to the ABC transporter superfamily
E3U39_03140	COG0444	Belongs to the ABC transporter superfamily
E3U39_03145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U39_03150	COG0601	transmembrane transport
E3U39_03155	COG4166	transmembrane transport
E3U39_03160	COG0180	Tryptophanyl-tRNA synthetase
E3U39_03170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U39_03175	COG0601	transmembrane transport
E3U39_03185	COG4608	Belongs to the ABC transporter superfamily
E3U39_03190	COG0444	Belongs to the ABC transporter superfamily
E3U39_03195	COG5504	Zn-dependent protease
E3U39_03200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U39_03205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3U39_03220	COG1744	ABC transporter substrate-binding protein PnrA-like
E3U39_03230	COG2267	carboxylic ester hydrolase activity
E3U39_03250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E3U39_03255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E3U39_03260	COG0505	Belongs to the CarA family
E3U39_03265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3U39_03285	COG2271	Major facilitator Superfamily
E3U39_03290	COG0277	FAD linked oxidase domain protein
E3U39_03300	COG2151	metal-sulfur cluster biosynthetic enzyme
E3U39_03305	COG1073	alpha beta
E3U39_03310	COG0561	phosphatase activity
E3U39_03325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_03330	COG1307	EDD domain protein, DegV family
E3U39_03340	COG2124	cytochrome p450
E3U39_03345	COG0840	transmembrane signaling receptor activity
E3U39_03355	COG2996	Protein conserved in bacteria
E3U39_03365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E3U39_03365	COG0646	methionine synthase
E3U39_03370	COG2153	protein acetylation
E3U39_03375	COG1357	PFAM Pentapeptide repeats (8 copies)
E3U39_03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_03385	COG1279	arginine transmembrane transporter activity
E3U39_03390	COG2318	DinB family
E3U39_03395	COG1917	Cupin 2, conserved barrel domain protein
E3U39_03395	COG2207	Transcriptional regulator
E3U39_03400	COG0534	Mate efflux family protein
E3U39_03405	COG1562	ergosterol biosynthetic process
E3U39_03410	COG0367	asparagine synthase
E3U39_03425	COG0179	Fumarylacetoacetate (FAA) hydrolase
E3U39_03465	COG1403	HNH endonuclease
E3U39_03470	COG0419	ATPase involved in DNA repair
E3U39_03475	COG0420	3'-5' exonuclease activity
E3U39_03495	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
E3U39_03505	COG2814	Major facilitator Superfamily
E3U39_03510	COG3180	Ammonia monooxygenase
E3U39_03515	COG1846	Transcriptional regulator
E3U39_03520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U39_03525	COG0681	Belongs to the peptidase S26 family
E3U39_03530	COG0398	Pfam SNARE associated Golgi protein
E3U39_03545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U39_03570	COG5646	InterPro IPR014922
E3U39_03580	COG4903	ComK protein
E3U39_03590	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_03595	COG0723	plastoquinol--plastocyanin reductase activity
E3U39_03595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U39_03600	COG0840	transmembrane signaling receptor activity
E3U39_03605	COG1268	BioY protein
E3U39_03610	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_03615	COG0183	Belongs to the thiolase family
E3U39_03620	COG0406	alpha-ribazole phosphatase activity
E3U39_03625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E3U39_03635	COG1404	Belongs to the peptidase S8 family
E3U39_03640	COG0501	Belongs to the peptidase M48B family
E3U39_03650	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_03655	COG0702	epimerase
E3U39_03660	COG0095	Lipoate-protein ligase
E3U39_03665	COG1234	tRNA 3'-trailer cleavage
E3U39_03675	COG1301	dicarboxylic acid transport
E3U39_03680	COG1363	Peptidase, m42
E3U39_03690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3U39_03695	COG1511	domain protein
E3U39_03700	COG1309	transcriptional regulator
E3U39_03720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3U39_03725	COG2329	Antibiotic biosynthesis monooxygenase
E3U39_03730	COG3069	C4-dicarboxylate transmembrane transporter activity
E3U39_03735	COG1473	amidohydrolase
E3U39_03745	COG4473	ABC transporter
E3U39_03750	COG1131	(ABC) transporter
E3U39_03755	COG0537	adenosine 5'-monophosphoramidase activity
E3U39_03760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E3U39_03775	COG4980	gas vesicle protein
E3U39_03815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U39_03830	COG4717	serine-type aminopeptidase activity
E3U39_03835	COG0420	3'-5' exonuclease activity
E3U39_03840	COG1668	transmembrane transport
E3U39_03845	COG4152	abc transporter atp-binding protein
E3U39_03855	COG1024	Enoyl-CoA hydratase
E3U39_03865	COG0490	domain, Protein
E3U39_03870	COG0475	glutathione-regulated potassium exporter activity
E3U39_03880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3U39_03885	COG0561	phosphatase activity
E3U39_03890	COG4335	DNA alkylation repair
E3U39_03905	COG0189	ligase activity
E3U39_03910	COG0189	ligase activity
E3U39_03930	COG0702	epimerase
E3U39_03935	COG1132	(ABC) transporter
E3U39_03940	COG1132	(ABC) transporter
E3U39_03945	COG0589	response to stress
E3U39_03955	COG3226	Transcriptional regulator
E3U39_03960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U39_03965	COG0726	polysaccharide deacetylase
E3U39_03970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E3U39_03975	COG0668	transmembrane transport
E3U39_03985	COG0584	glycerophosphoryl diester phosphodiesterase
E3U39_03990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3U39_03995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E3U39_04000	COG1253	flavin adenine dinucleotide binding
E3U39_04005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U39_04010	COG0436	Aminotransferase
E3U39_04015	COG0789	Transcriptional regulator
E3U39_04020	COG1253	flavin adenine dinucleotide binding
E3U39_04025	COG0204	Acyl-transferase
E3U39_04030	COG1595	DNA-templated transcription, initiation
E3U39_04045	COG0733	neurotransmitter:sodium symporter activity
E3U39_04050	COG0531	amino acid
E3U39_04055	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_04060	COG0372	Belongs to the citrate synthase family
E3U39_04065	COG0583	DNA-binding transcription factor activity
E3U39_04070	COG0791	NLP P60 protein
E3U39_04070	COG1388	LysM domain
E3U39_04075	COG1785	Belongs to the alkaline phosphatase family
E3U39_04080	COG2719	SpoVR family
E3U39_04085	COG0668	transmembrane transport
E3U39_04095	COG1959	2 iron, 2 sulfur cluster binding
E3U39_04100	COG0791	NLP P60 protein
E3U39_04100	COG1388	LysM domain
E3U39_04115	COG0431	NADPH-dependent FMN reductase
E3U39_04120	COG2197	response regulator
E3U39_04130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E3U39_04135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E3U39_04145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E3U39_04150	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E3U39_04155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3U39_04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E3U39_04160	COG3153	acetyltransferase
E3U39_04165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E3U39_04170	COG0517	IMP dehydrogenase activity
E3U39_04180	COG0564	pseudouridine synthase activity
E3U39_04185	COG3764	Sortase (surface protein transpeptidase)
E3U39_04190	COG1525	nuclease
E3U39_04190	COG0737	Belongs to the 5'-nucleotidase family
E3U39_04190	COG4085	toxin activity
E3U39_04195	COG5577	PFAM Coat F domain
E3U39_04215	COG1823	symporter activity
E3U39_04220	COG3706	GGDEF domain
E3U39_04225	COG1464	Belongs to the NlpA lipoprotein family
E3U39_04235	COG1278	Cold shock
E3U39_04240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E3U39_04245	COG1131	(ABC) transporter
E3U39_04250	COG1131	(ABC) transporter
E3U39_04255	COG1725	Transcriptional regulator
E3U39_04270	COG0655	NAD(P)H dehydrogenase (quinone) activity
E3U39_04275	COG2814	Major facilitator Superfamily
E3U39_04280	COG1566	PFAM secretion protein HlyD family protein
E3U39_04285	COG1846	Transcriptional regulator
E3U39_04295	COG2766	serine protein kinase
E3U39_04300	COG1664	Polymer-forming cytoskeletal
E3U39_04305	COG1664	Polymer-forming cytoskeletal
E3U39_04310	COG0789	Transcriptional regulator
E3U39_04315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E3U39_04325	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E3U39_04330	COG3382	B3 4 domain protein
E3U39_04340	COG1476	TRANSCRIPTIONal
E3U39_04360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3U39_04365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3U39_04370	COG1116	anion transmembrane transporter activity
E3U39_04385	COG0753	catalase activity
E3U39_04390	COG4608	Belongs to the ABC transporter superfamily
E3U39_04395	COG0444	Belongs to the ABC transporter superfamily
E3U39_04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E3U39_04405	COG0601	transmembrane transport
E3U39_04410	COG0747	negative chemotaxis
E3U39_04420	COG0277	FAD linked oxidase domain protein
E3U39_04430	COG3340	Belongs to the peptidase S51 family
E3U39_04545	COG0735	belongs to the Fur family
E3U39_04550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E3U39_04560	COG4129	membrane
E3U39_04565	COG1132	(ABC) transporter
E3U39_04585	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_04595	COG1194	a g-specific adenine glycosylase
E3U39_04600	COG1988	membrane-bound metal-dependent
E3U39_04605	COG4485	Bacterial membrane protein, YfhO
E3U39_04610	COG0463	Glycosyl transferase, family 2
E3U39_04615	COG0596	Alpha beta hydrolase
E3U39_04620	COG5658	integral membrane protein
E3U39_04625	COG3103	Sh3 type 3 domain protein
E3U39_04640	COG3591	Belongs to the peptidase S1B family
E3U39_04650	COG2814	Major facilitator Superfamily
E3U39_04665	COG1090	epimerase
E3U39_04680	COG0778	Nitroreductase
E3U39_04685	COG0384	phenazine biosynthesis protein PhzF
E3U39_04690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
E3U39_04690	COG0392	lysyltransferase activity
E3U39_04695	COG1846	Transcriptional regulator
E3U39_04700	COG2814	Major facilitator Superfamily
E3U39_04705	COG2318	DinB family
E3U39_04710	COG2732	(Barnase) inhibitor
E3U39_04715	COG0574	Belongs to the PEP-utilizing enzyme family
E3U39_04715	COG3848	Pyruvate phosphate dikinase
E3U39_04725	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
E3U39_04730	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3U39_04735	COG1695	Transcriptional regulator
E3U39_04750	COG2514	catechol 2,3-dioxygenase activity
E3U39_04755	COG2259	Doxx family
E3U39_04760	COG1132	(ABC) transporter
E3U39_04765	COG1132	(ABC) transporter
E3U39_04770	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_04775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_04775	COG1263	PTS System
E3U39_04780	COG1737	Transcriptional regulator
E3U39_04785	COG1486	melibiose metabolic process
E3U39_04795	COG3284	Transcriptional regulator
E3U39_04800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U39_04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U39_04810	COG0022	dehydrogenase e1 component
E3U39_04815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3U39_04820	COG4637	Psort location Cytoplasmic, score
E3U39_04825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3U39_04840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3U39_04845	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E3U39_04850	COG0598	Magnesium transport protein CorA
E3U39_04860	COG2084	Dehydrogenase
E3U39_04865	COG0726	polysaccharide deacetylase
E3U39_04875	COG0535	radical SAM domain protein
E3U39_04880	COG0668	transmembrane transport
E3U39_04890	COG0387	Pfam Sodium calcium exchanger
E3U39_04895	COG0477	Major facilitator Superfamily
E3U39_04900	COG1295	ribonuclease BN
E3U39_04905	COG4980	gas vesicle protein
E3U39_04910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3U39_04920	COG2814	Major facilitator Superfamily
E3U39_04930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3U39_04935	COG1609	Transcriptional regulator
E3U39_04940	COG0693	protein deglycase activity
E3U39_04945	COG0737	Belongs to the 5'-nucleotidase family
E3U39_04960	COG0778	Nitroreductase
E3U39_04965	COG2188	Transcriptional regulator
E3U39_04970	COG0366	Alpha amylase catalytic
E3U39_04975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_04975	COG1263	PTS System
E3U39_04990	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U39_05000	COG1368	sulfuric ester hydrolase activity
E3U39_05010	COG1263	PTS System
E3U39_05010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_05015	COG0024	Methionine aminopeptidase
E3U39_05035	COG2258	MOSC domain
E3U39_05045	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
E3U39_05050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_05055	COG2851	Citrate transporter
E3U39_05060	COG3181	Tripartite tricarboxylate transporter family receptor
E3U39_05065	COG4565	transcriptional regulatory protein
E3U39_05070	COG3290	protein histidine kinase activity
E3U39_05090	COG0471	metal ion transport
E3U39_05095	COG3866	Pectate lyase
E3U39_05110	COG2130	NADP-dependent
E3U39_05115	COG0456	acetyltransferase
E3U39_05120	COG0513	Belongs to the DEAD box helicase family
E3U39_05125	COG0488	(ABC) transporter
E3U39_05130	COG2814	Major facilitator Superfamily
E3U39_05135	COG0789	Transcriptional regulator
E3U39_05140	COG0488	(ABC) transporter
E3U39_05145	COG0457	Tetratricopeptide repeat
E3U39_05145	COG0463	Glycosyl transferase, family 2
E3U39_05150	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_05155	COG0840	transmembrane signaling receptor activity
E3U39_05160	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_05165	COG0531	amino acid
E3U39_05170	COG2223	nitrite transmembrane transporter activity
E3U39_05175	COG1442	glycosyl transferase family 8
E3U39_05180	COG1216	Glycosyl transferase, family 2
E3U39_05185	COG1442	glycosyl transferase family 8
E3U39_05190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_05195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E3U39_05200	COG1368	sulfuric ester hydrolase activity
E3U39_05205	COG2124	cytochrome p450
E3U39_05205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3U39_05215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E3U39_05220	COG1846	Transcriptional regulator
E3U39_05230	COG0670	Belongs to the BI1 family
E3U39_05235	COG0196	riboflavin kinase activity
E3U39_05240	COG5583	Uncharacterized small protein (DUF2292)
E3U39_05245	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_05250	COG0346	lactoylglutathione lyase activity
E3U39_05255	COG2329	Antibiotic biosynthesis monooxygenase
E3U39_05260	COG2323	membrane
E3U39_05270	COG0454	-acetyltransferase
E3U39_05275	COG3546	catalase activity
E3U39_05305	COG5444	nuclease activity
E3U39_05335	COG1131	(ABC) transporter
E3U39_05345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E3U39_05350	COG1597	lipid kinase activity
E3U39_05355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E3U39_05360	COG1309	transcriptional regulator
E3U39_05380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U39_05385	COG1285	pathogenesis
E3U39_05390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3U39_05395	COG4851	CamS sex pheromone cAM373 precursor
E3U39_05405	COG0210	DNA helicase
E3U39_05415	COG0069	glutamate synthase activity
E3U39_05420	COG4496	protein, YerC YecD
E3U39_05425	COG1470	cell adhesion involved in biofilm formation
E3U39_05430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E3U39_05440	COG0151	Belongs to the GarS family
E3U39_05445	COG0138	bifunctional purine biosynthesis protein purh
E3U39_05450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E3U39_05460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E3U39_05475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E3U39_05480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E3U39_05485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E3U39_05490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E3U39_05495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E3U39_05515	COG3064	Membrane
E3U39_05520	COG2252	PERMEase
E3U39_05545	COG1305	Transglutaminase-like
E3U39_05550	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
E3U39_05555	COG0714	Associated with various cellular activities
E3U39_05560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3U39_05565	COG1113	amino acid transport
E3U39_05570	COG2132	Multicopper oxidase
E3U39_05580	COG0823	Involved in the tonB-independent uptake of proteins
E3U39_05585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E3U39_05590	COG1063	alcohol dehydrogenase
E3U39_05595	COG1595	DNA-templated transcription, initiation
E3U39_05605	COG2755	lipolytic protein G-D-S-L family
E3U39_05605	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E3U39_05610	COG4260	virion core protein, lumpy skin disease virus
E3U39_05615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E3U39_05620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E3U39_05625	COG1842	Phage shock protein A
E3U39_05635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3U39_05640	COG2211	Major facilitator Superfamily
E3U39_05645	COG1063	alcohol dehydrogenase
E3U39_05650	COG0457	Tetratricopeptide repeat
E3U39_05800	COG5484	DNA packaging
E3U39_05825	COG1595	DNA-templated transcription, initiation
E3U39_05920	COG1484	DNA-dependent DNA replication
E3U39_05925	COG3935	DnaD domain protein
E3U39_05935	COG3723	Recombinational DNA repair protein, rece pathway
E3U39_05940	COG5377	YqaJ viral recombinase family
E3U39_05990	COG1396	sequence-specific DNA binding
E3U39_06000	COG2856	Zn peptidase
E3U39_06015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E3U39_06020	COG1266	CAAX protease self-immunity
E3U39_06030	COG0805	protein transport
E3U39_06035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U39_06050	COG0488	(ABC) transporter
E3U39_06055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E3U39_06060	COG0456	acetyltransferase
E3U39_06065	COG1214	PFAM Peptidase M22, glycoprotease
E3U39_06070	COG0802	atpase or kinase
E3U39_06075	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E3U39_06115	COG2814	Major facilitator Superfamily
E3U39_06120	COG0604	alcohol dehydrogenase
E3U39_06125	COG3832	glyoxalase III activity
E3U39_06135	COG0531	amino acid
E3U39_06140	COG1309	transcriptional regulator
E3U39_06145	COG2076	Multidrug Resistance protein
E3U39_06150	COG2076	Multidrug Resistance protein
E3U39_06155	COG2807	transmembrane transport
E3U39_06160	COG2186	Transcriptional regulator
E3U39_06165	COG2188	Transcriptional regulator
E3U39_06170	COG2814	Major facilitator Superfamily
E3U39_06175	COG1388	LysM domain
E3U39_06180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3U39_06195	COG1819	glycosyl
E3U39_06200	COG1802	Transcriptional regulator
E3U39_06205	COG0473	3-isopropylmalate dehydrogenase activity
E3U39_06210	COG2226	methyltransferase
E3U39_06215	COG1051	belongs to the nudix hydrolase family
E3U39_06225	COG0456	acetyltransferase
E3U39_06230	COG0730	response to heat
E3U39_06240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E3U39_06245	COG2814	Major facilitator Superfamily
E3U39_06255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_06260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_06270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E3U39_06275	COG2409	Drug exporters of the RND superfamily
E3U39_06280	COG2197	response regulator
E3U39_06285	COG4585	Histidine kinase
E3U39_06300	COG5577	PFAM Coat F domain
E3U39_06305	COG1063	alcohol dehydrogenase
E3U39_06315	COG5577	PFAM Coat F domain
E3U39_06320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_06325	COG0697	spore germination
E3U39_06330	COG1309	transcriptional regulator
E3U39_06335	COG2814	Major facilitator Superfamily
E3U39_06350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_06360	COG0789	Transcriptional regulator
E3U39_06365	COG1064	alcohol dehydrogenase
E3U39_06380	COG0351	phosphomethylpyrimidine kinase
E3U39_06415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E3U39_06420	COG2318	DinB family
E3U39_06425	COG0662	Cupin 2, conserved barrel domain protein
E3U39_06450	COG0277	FAD linked oxidase domain protein
E3U39_06465	COG0662	Cupin 2, conserved barrel domain protein
E3U39_06475	COG3621	Patatin-like phospholipase
E3U39_06490	COG1794	racemase activity, acting on amino acids and derivatives
E3U39_06495	COG0730	response to heat
E3U39_06500	COG0425	Belongs to the sulfur carrier protein TusA family
E3U39_06505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U39_06505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_06510	COG0425	Belongs to the sulfur carrier protein TusA family
E3U39_06510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U39_06520	COG2210	Belongs to the sulfur carrier protein TusA family
E3U39_06525	COG1937	Protein conserved in bacteria
E3U39_06530	COG1329	Transcriptional regulator
E3U39_06535	COG1278	Cold shock
E3U39_06545	COG2910	NAD(P)H-binding
E3U39_06550	COG1959	2 iron, 2 sulfur cluster binding
E3U39_06565	COG2030	dehydratase
E3U39_06585	COG0477	Major facilitator Superfamily
E3U39_06590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3U39_06600	COG0457	Tetratricopeptide repeat
E3U39_06605	COG1090	epimerase
E3U39_06610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3U39_06615	COG1959	2 iron, 2 sulfur cluster binding
E3U39_06680	COG2183	response to ionizing radiation
E3U39_06685	COG2208	phosphoserine phosphatase activity
E3U39_06690	COG1191	sigma factor activity
E3U39_06700	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_06705	COG2208	phosphoserine phosphatase activity
E3U39_06710	COG2172	sigma factor antagonist activity
E3U39_06715	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_06720	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_06725	COG2337	Toxic component of a toxin-antitoxin (TA) module
E3U39_06730	COG0864	Transcriptional regulator
E3U39_06735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3U39_06740	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E3U39_06750	COG0705	Rhomboid family
E3U39_06755	COG3428	Bacterial PH domain
E3U39_06760	COG3402	PFAM membrane-flanked domain
E3U39_06765	COG0513	Belongs to the DEAD box helicase family
E3U39_06770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E3U39_06780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_06785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3U39_06800	COG1960	acyl-CoA dehydrogenase activity
E3U39_06810	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E3U39_06815	COG1131	(ABC) transporter
E3U39_06820	COG0628	permease
E3U39_06825	COG1301	dicarboxylic acid transport
E3U39_06830	COG4565	transcriptional regulatory protein
E3U39_06835	COG3290	protein histidine kinase activity
E3U39_06840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E3U39_06845	COG3546	catalase activity
E3U39_06850	COG2329	Antibiotic biosynthesis monooxygenase
E3U39_06855	COG0662	Cupin 2, conserved barrel domain protein
E3U39_06860	COG3729	General stress protein
E3U39_06865	COG2217	Heavy metal translocating P-type atpase
E3U39_06870	COG2076	Multidrug Resistance protein
E3U39_06900	COG1914	H( )-stimulated, divalent metal cation uptake system
E3U39_06950	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3U39_06950	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_06950	COG1388	LysM domain
E3U39_06955	COG0028	Belongs to the TPP enzyme family
E3U39_06965	COG0531	amino acid
E3U39_06975	COG1215	transferase activity, transferring glycosyl groups
E3U39_06980	COG5298	Protein conserved in bacteria
E3U39_06985	COG3706	GGDEF domain
E3U39_06990	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E3U39_06995	COG0551	DNA topoisomerase type I activity
E3U39_06995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E3U39_07000	COG1522	sequence-specific DNA binding
E3U39_07005	COG2814	Major facilitator Superfamily
E3U39_07015	COG3871	stress protein (general stress protein 26)
E3U39_07020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_07025	COG1917	Cupin 2, conserved barrel domain protein
E3U39_07030	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_07035	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_07040	COG3711	transcriptional antiterminator
E3U39_07045	COG4989	oxidoreductase activity
E3U39_07050	COG0768	penicillin binding
E3U39_07055	COG2329	Antibiotic biosynthesis monooxygenase
E3U39_07065	COG2755	lipolytic protein G-D-S-L family
E3U39_07070	COG1414	Transcriptional regulator
E3U39_07075	COG1984	allophanate hydrolase subunit 2
E3U39_07080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E3U39_07090	COG1914	H( )-stimulated, divalent metal cation uptake system
E3U39_07100	COG0561	phosphatase activity
E3U39_07110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E3U39_07120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_07125	COG2213	PTS system mannitol-specific
E3U39_07135	COG1349	DNA-binding transcription factor activity
E3U39_07140	COG2372	response to copper ion
E3U39_07140	COG1276	copper resistance
E3U39_07145	COG4549	nuclear export factor GLE1
E3U39_07150	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_07155	COG4975	Glucose uptake
E3U39_07160	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_07165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3U39_07170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_07175	COG0640	Transcriptional regulator
E3U39_07180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E3U39_07185	COG0778	Nitroreductase
E3U39_07190	COG1309	transcriptional regulator
E3U39_07195	COG2814	Major facilitator Superfamily
E3U39_07200	COG4607	ABC-type enterochelin transport system periplasmic component
E3U39_07205	COG4604	ABC transporter, ATP-binding protein
E3U39_07210	COG4605	iron ion homeostasis
E3U39_07215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_07220	COG0527	aspartate kinase activity
E3U39_07235	COG0457	Tetratricopeptide repeat
E3U39_07240	COG5002	protein histidine kinase activity
E3U39_07240	COG3850	Histidine kinase
E3U39_07245	COG0745	RESPONSE REGULATOR receiver
E3U39_07250	COG0577	efflux transmembrane transporter activity
E3U39_07255	COG1136	(ABC) transporter
E3U39_07260	COG2079	MmgE PrpD family protein
E3U39_07270	COG1126	abc transporter atp-binding protein
E3U39_07275	COG0765	amino acid transport
E3U39_07280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_07295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3U39_07305	COG0697	spore germination
E3U39_07315	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_07320	COG3104	oligopeptide transport
E3U39_07335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E3U39_07340	COG0163	prenyltransferase activity
E3U39_07345	COG0583	DNA-binding transcription factor activity
E3U39_07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_07355	COG0765	amino acid transport
E3U39_07360	COG1126	abc transporter atp-binding protein
E3U39_07365	COG2364	Membrane
E3U39_07380	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E3U39_07385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_07390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_07395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_07400	COG1733	regulation of RNA biosynthetic process
E3U39_07405	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E3U39_07410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E3U39_07415	COG3209	COG3209 Rhs family protein
E3U39_07425	COG2723	6-phospho-beta-galactosidase activity
E3U39_07435	COG1714	RDD family
E3U39_07440	COG1063	alcohol dehydrogenase
E3U39_07445	COG0523	cobalamin synthesis protein
E3U39_07450	COG2223	nitrite transmembrane transporter activity
E3U39_07455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3U39_07460	COG0243	molybdopterin cofactor binding
E3U39_07465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E3U39_07470	COG2146	nitrite reductase [NAD(P)H] activity
E3U39_07475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E3U39_07475	COG1587	Uroporphyrinogen-III synthase
E3U39_07485	COG2508	Transcriptional regulator
E3U39_07490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U39_07495	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_07500	COG0506	proline dehydrogenase activity
E3U39_07505	COG3541	Predicted nucleotidyltransferase
E3U39_07510	COG3458	cephalosporin-C deacetylase activity
E3U39_07515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E3U39_07520	COG2271	Major facilitator Superfamily
E3U39_07525	COG1082	Xylose isomerase domain protein TIM barrel
E3U39_07530	COG1660	Displays ATPase and GTPase activities
E3U39_07545	COG3665	Urea carboxylase-associated protein
E3U39_07550	COG1113	amino acid transport
E3U39_07555	COG3403	YqcI/YcgG family
E3U39_07560	COG1280	lysine exporter protein (LysE YggA)
E3U39_07565	COG1846	Transcriptional regulator
E3U39_07570	COG2814	Major facilitator Superfamily
E3U39_07580	COG0366	Alpha amylase catalytic
E3U39_07590	COG1288	antiporter activity
E3U39_07595	COG1473	amidohydrolase
E3U39_07600	COG2113	Glycine betaine
E3U39_07605	COG4176	ABC-type proline glycine betaine transport system permease component
E3U39_07610	COG4175	Glycine betaine
E3U39_07610	COG0517	IMP dehydrogenase activity
E3U39_07615	COG0477	Major facilitator Superfamily
E3U39_07620	COG3853	Toxic anion resistance protein (TelA)
E3U39_07630	COG0861	Integral membrane protein TerC family
E3U39_07635	COG2310	stress, protein
E3U39_07640	COG2310	stress, protein
E3U39_07645	COG2310	stress, protein
E3U39_07650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3U39_07655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E3U39_07660	COG1121	(ABC) transporter
E3U39_07665	COG0803	Belongs to the bacterial solute-binding protein 9 family
E3U39_07670	COG0366	Alpha amylase catalytic
E3U39_07675	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_07680	COG0457	Tetratricopeptide repeat
E3U39_07685	COG1876	peptidase activity
E3U39_07690	COG1595	DNA-templated transcription, initiation
E3U39_07695	COG1595	DNA-templated transcription, initiation
E3U39_07705	COG0667	Aldo Keto reductase
E3U39_07710	COG3012	SEC-C Motif Domain Protein
E3U39_07710	COG1405	negative regulation of cell septum assembly
E3U39_07715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E3U39_07720	COG0252	asparaginase activity
E3U39_07725	COG1309	transcriptional regulator
E3U39_07730	COG0477	Major facilitator Superfamily
E3U39_07735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U39_07745	COG0805	protein transport
E3U39_07750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E3U39_07755	COG3540	Alkaline phosphatase
E3U39_07765	COG3773	Cell wall hydrolase
E3U39_07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_07785	COG2259	Doxx family
E3U39_07790	COG0346	lactoylglutathione lyase activity
E3U39_07795	COG0778	Nitroreductase
E3U39_07800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3U39_07820	COG0784	Response regulator, receiver
E3U39_07825	COG4191	Histidine kinase
E3U39_07830	COG2066	Belongs to the glutaminase family
E3U39_07835	COG1115	amino acid carrier protein
E3U39_07840	COG2040	homocysteine
E3U39_07845	COG0833	amino acid
E3U39_07850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U39_07855	COG1301	dicarboxylic acid transport
E3U39_07870	COG0688	phosphatidylethanolamine metabolic process
E3U39_07875	COG0586	Pfam SNARE associated Golgi protein
E3U39_07880	COG1183	phosphatidylcholine synthase activity
E3U39_07890	COG0371	Dehydrogenase
E3U39_07905	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_07915	COG2368	4-hydroxyphenylacetate
E3U39_07930	COG2271	Major facilitator Superfamily
E3U39_07935	COG0584	glycerophosphoryl diester phosphodiesterase
E3U39_07945	COG0531	amino acid
E3U39_07985	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_07985	COG3321	synthase
E3U39_07985	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_07985	COG0300	oxidoreductase activity
E3U39_07985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_07990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_07990	COG4221	oxidoreductase activity
E3U39_07990	COG3321	synthase
E3U39_07990	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_08010	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E3U39_08030	COG1131	(ABC) transporter
E3U39_08035	COG2197	response regulator
E3U39_08040	COG4585	Histidine kinase
E3U39_08045	COG1011	Hydrolase
E3U39_08050	COG1113	amino acid transport
E3U39_08055	COG1846	Transcriptional regulator
E3U39_08060	COG1380	Effector of murein hydrolase LrgA
E3U39_08065	COG1346	cytolysis
E3U39_08105	COG4856	YbbR-like protein
E3U39_08110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3U39_08115	COG5662	AntiSigma factor
E3U39_08120	COG1595	DNA-templated transcription, initiation
E3U39_08150	COG1683	Conserved Protein
E3U39_08155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_08165	COG1263	PTS System
E3U39_08165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_08170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E3U39_08175	COG1472	Belongs to the glycosyl hydrolase 3 family
E3U39_08180	COG3876	Protein conserved in bacteria
E3U39_08185	COG2207	Transcriptional regulator
E3U39_08185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U39_08190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U39_08195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_08205	COG2819	hydrolase of the alpha beta superfamily
E3U39_08210	COG0385	Bile acid
E3U39_08215	COG0659	secondary active sulfate transmembrane transporter activity
E3U39_08230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E3U39_08295	COG0726	polysaccharide deacetylase
E3U39_08300	COG2194	sulfuric ester hydrolase activity
E3U39_08310	COG0489	protein tyrosine kinase activity
E3U39_08315	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_08325	COG2318	DinB family
E3U39_08330	COG2226	methyltransferase
E3U39_08350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E3U39_08355	COG1122	ATPase activity
E3U39_08360	COG1122	ATPase activity
E3U39_08385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E3U39_08390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E3U39_08400	COG0024	Methionine aminopeptidase
E3U39_08410	COG0201	protein transport
E3U39_08420	COG1841	ribosomal large subunit assembly
E3U39_08470	COG0255	Belongs to the universal ribosomal protein uL29 family
E3U39_08475	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E3U39_08485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E3U39_08490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E3U39_08500	COG0089	rRNA binding
E3U39_08515	COG0051	transcription antitermination factor activity, RNA binding
E3U39_08520	COG0596	Alpha beta hydrolase
E3U39_08545	COG1358	cellular component organization or biogenesis
E3U39_08560	COG2813	Specifically methylates the guanine in position
E3U39_08565	COG0222	ribosome binding
E3U39_08580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E3U39_08585	COG0250	Participates in transcription elongation, termination and antitermination
E3U39_08590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3U39_08595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3U39_08600	COG1595	DNA-templated transcription, initiation
E3U39_08605	COG3688	RNA-binding protein containing a PIN domain
E3U39_08610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3U39_08615	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
E3U39_08625	COG1045	serine acetyltransferase
E3U39_08645	COG4956	integral membrane protein (PIN domain superfamily)
E3U39_08650	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
E3U39_08655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E3U39_08660	COG0542	response to heat
E3U39_08670	COG3880	PFAM UvrB UvrC protein
E3U39_08675	COG4463	regulation of RNA biosynthetic process
E3U39_08755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E3U39_08760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E3U39_08765	COG1396	sequence-specific DNA binding
E3U39_08770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E3U39_08775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E3U39_08780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E3U39_08785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U39_08790	COG0512	Glutamine amidotransferase of anthranilate synthase
E3U39_08795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3U39_08800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3U39_08805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E3U39_08820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E3U39_08830	COG0037	tRNA processing
E3U39_08835	COG0515	serine threonine protein kinase
E3U39_08840	COG2304	oxidoreductase activity
E3U39_08845	COG2208	phosphoserine phosphatase activity
E3U39_08860	COG1098	S1 RNA binding domain
E3U39_08865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E3U39_08880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E3U39_08885	COG3956	TIGRFAM MazG family protein
E3U39_08890	COG2244	polysaccharide biosynthetic process
E3U39_08895	COG2002	toxin-antitoxin pair type II binding
E3U39_08900	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E3U39_08920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E3U39_08935	COG0251	oxidation-reduction process
E3U39_08940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E3U39_08955	COG4466	Protein conserved in bacteria
E3U39_08965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E3U39_08970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3U39_08975	COG3583	domain protein
E3U39_08975	COG3584	3D domain protein
E3U39_08980	COG0084	hydrolase, TatD family'
E3U39_08985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U39_08985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U39_08990	COG2002	toxin-antitoxin pair type II binding
E3U39_08995	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E3U39_09005	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E3U39_09015	COG1774	PSP1 C-terminal conserved region
E3U39_09020	COG0470	DNA polymerase III
E3U39_09025	COG1728	Protein conserved in bacteria
E3U39_09030	COG3870	Protein conserved in bacteria
E3U39_09040	COG1982	Orn Lys Arg decarboxylase major
E3U39_09045	COG3853	Toxic anion resistance protein (TelA)
E3U39_09050	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
E3U39_09085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E3U39_09090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E3U39_09095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E3U39_09105	COG0590	tRNA wobble adenosine to inosine editing
E3U39_09110	COG1335	isochorismatase
E3U39_09115	COG1388	LysM domain
E3U39_09115	COG3858	chitin binding
E3U39_09120	COG1428	Deoxynucleoside kinase
E3U39_09125	COG1428	Deoxynucleoside kinase
E3U39_09135	COG1929	Belongs to the glycerate kinase type-1 family
E3U39_09155	COG1686	Belongs to the peptidase S11 family
E3U39_09160	COG0517	IMP dehydrogenase activity
E3U39_09160	COG0516	GMP reductase activity
E3U39_09195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3U39_09200	COG0187	DNA topoisomerase II activity
E3U39_09215	COG2501	S4 domain
E3U39_09220	COG0592	DNA-directed DNA polymerase activity
E3U39_09230	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E3U39_09240	COG0706	membrane insertase activity
E3U39_09245	COG1847	R3H domain protein
E3U39_09270	COG1192	Involved in chromosome partitioning
E3U39_09275	COG1475	DNA binding
E3U39_09290	COG3949	Membrane
E3U39_09295	COG4481	Protein conserved in bacteria
E3U39_09300	COG0243	molybdopterin cofactor binding
E3U39_09305	COG0012	GTP binding
E3U39_09315	COG0629	single-stranded DNA binding
E3U39_09325	COG2169	Transcriptional regulator
E3U39_09330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E3U39_09335	COG0708	Exodeoxyribonuclease III
E3U39_09340	COG1609	Transcriptional regulator
E3U39_09345	COG0346	lactoylglutathione lyase activity
E3U39_09350	COG2814	Major facilitator Superfamily
E3U39_09350	COG0477	Major facilitator Superfamily
E3U39_09355	COG1266	CAAX protease self-immunity
E3U39_09360	COG1331	Highly conserved protein containing a thioredoxin domain
E3U39_09365	COG0697	spore germination
E3U39_09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_09375	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_09380	COG0583	DNA-binding transcription factor activity
E3U39_09385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3U39_09395	COG2153	protein acetylation
E3U39_09400	COG1846	Transcriptional regulator
E3U39_09405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_09410	COG1846	Transcriptional regulator
E3U39_09415	COG0778	Nitroreductase
E3U39_09425	COG0697	spore germination
E3U39_09430	COG2211	Major facilitator Superfamily
E3U39_09435	COG2318	DinB family
E3U39_09440	COG1802	Transcriptional regulator
E3U39_09445	COG1621	beta-fructofuranosidase activity
E3U39_09450	COG1621	beta-fructofuranosidase activity
E3U39_09455	COG0697	spore germination
E3U39_09465	COG1733	regulation of RNA biosynthetic process
E3U39_09470	COG5577	PFAM Coat F domain
E3U39_09480	COG4241	membrane
E3U39_09485	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E3U39_09495	COG2112	serine threonine protein kinase
E3U39_09505	COG0438	transferase activity, transferring glycosyl groups
E3U39_09510	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E3U39_09520	COG0297	glycogen (starch) synthase activity
E3U39_09525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E3U39_09530	COG3093	addiction module antidote protein HigA
E3U39_09550	COG0305	Participates in initiation and elongation during chromosome replication
E3U39_09555	COG0346	lactoylglutathione lyase activity
E3U39_09590	COG0745	RESPONSE REGULATOR receiver
E3U39_09595	COG5002	protein histidine kinase activity
E3U39_09600	COG4863	YycH protein
E3U39_09605	COG4853	Protein conserved in bacteria
E3U39_09610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E3U39_09615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U39_09620	COG0745	RESPONSE REGULATOR receiver
E3U39_09625	COG3850	Histidine kinase
E3U39_09625	COG5002	protein histidine kinase activity
E3U39_09630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E3U39_09645	COG0488	(ABC) transporter
E3U39_09655	COG3829	transcription factor binding
E3U39_09660	COG0640	Transcriptional regulator
E3U39_09665	COG5658	integral membrane protein
E3U39_09670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E3U39_09675	COG0833	amino acid
E3U39_09680	COG0010	Belongs to the arginase family
E3U39_09685	COG0457	Tetratricopeptide repeat
E3U39_09690	COG0456	acetyltransferase
E3U39_09695	COG0667	Aldo Keto reductase
E3U39_09700	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E3U39_09750	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E3U39_09755	COG2068	MobA-Related Protein
E3U39_09770	COG2080	2 iron, 2 sulfur cluster binding
E3U39_09780	COG1113	amino acid transport
E3U39_09785	COG3177	Filamentation induced by cAMP protein fic
E3U39_09790	COG3634	alkyl hydroperoxide reductase activity
E3U39_09795	COG0450	alkyl hydroperoxide reductase
E3U39_09805	COG1714	RDD family
E3U39_09810	COG2814	Major facilitator Superfamily
E3U39_09815	COG0640	Transcriptional regulator
E3U39_09825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E3U39_09830	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_09835	COG1309	transcriptional regulator
E3U39_09845	COG3239	Fatty acid desaturase
E3U39_09850	COG4585	Histidine kinase
E3U39_09855	COG2197	response regulator
E3U39_09860	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_09875	COG2814	Major facilitator Superfamily
E3U39_09880	COG0667	Aldo Keto reductase
E3U39_09885	COG1349	DNA-binding transcription factor activity
E3U39_09915	COG2814	Major facilitator Superfamily
E3U39_09925	COG1082	Xylose isomerase domain protein TIM barrel
E3U39_09955	COG0745	RESPONSE REGULATOR receiver
E3U39_09960	COG2205	protein histidine kinase activity
E3U39_09965	COG0745	RESPONSE REGULATOR receiver
E3U39_09970	COG2205	protein histidine kinase activity
E3U39_09975	COG1136	(ABC) transporter
E3U39_09980	COG0577	efflux transmembrane transporter activity
E3U39_09985	COG5294	Protein conserved in bacteria
E3U39_09990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U39_10020	COG0561	phosphatase activity
E3U39_10025	COG2390	Transcriptional regulator
E3U39_10035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3U39_10040	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E3U39_10045	COG0833	amino acid
E3U39_10050	COG0010	Belongs to the arginase family
E3U39_10075	COG3507	Belongs to the glycosyl hydrolase 43 family
E3U39_10080	COG0494	nUDIX hydrolase
E3U39_10095	COG0589	response to stress
E3U39_10100	COG0697	spore germination
E3U39_10110	COG3209	COG3209 Rhs family protein
E3U39_10200	COG0513	Belongs to the DEAD box helicase family
E3U39_10205	COG2270	Major facilitator Superfamily
E3U39_10210	COG3711	transcriptional antiterminator
E3U39_10215	COG2273	Hydrolase Family 16
E3U39_10220	COG2851	Citrate transporter
E3U39_10225	COG0753	catalase activity
E3U39_10225	COG0693	protein deglycase activity
E3U39_10245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3U39_10250	COG0500	methyltransferase
E3U39_10255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E3U39_10260	COG4894	glucomannan catabolic process
E3U39_10270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E3U39_10280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_10285	COG2508	Transcriptional regulator
E3U39_10290	COG3842	ATPase activity
E3U39_10295	COG0726	polysaccharide deacetylase
E3U39_10300	COG3493	citrate carrier protein
E3U39_10305	COG1271	oxidase subunit
E3U39_10310	COG1294	oxidase, subunit
E3U39_10315	COG4988	ABC transporter
E3U39_10320	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E3U39_10325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E3U39_10330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E3U39_10335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E3U39_10340	COG0753	catalase activity
E3U39_10350	COG1482	cell wall glycoprotein biosynthetic process
E3U39_10355	COG1940	carbohydrate kinase activity
E3U39_10360	COG2723	6-phospho-beta-galactosidase activity
E3U39_10365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_10370	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3U39_10375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_10380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3U39_10385	COG0640	Transcriptional regulator
E3U39_10395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_10400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_10415	COG3711	transcriptional antiterminator
E3U39_10415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_10420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_10425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_10430	COG1447	Phosphotransferase system cellobiose-specific component IIA
E3U39_10435	COG1486	melibiose metabolic process
E3U39_10440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E3U39_10445	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E3U39_10455	COG1696	Membrane protein involved in D-alanine export
E3U39_10480	COG1575	Belongs to the MenA family. Type 1 subfamily
E3U39_10495	COG1442	glycosyl transferase family 8
E3U39_10500	COG1404	Belongs to the peptidase S8 family
E3U39_10505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E3U39_10510	COG0346	lactoylglutathione lyase activity
E3U39_10515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E3U39_10520	COG5504	Zn-dependent protease
E3U39_10525	COG0789	Transcriptional regulator
E3U39_10530	COG4895	conserved protein (DUF2196)
E3U39_10535	COG1346	cytolysis
E3U39_10545	COG0583	DNA-binding transcription factor activity
E3U39_10560	COG2822	iron ion transport
E3U39_10565	COG2837	iron assimilation
E3U39_10570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E3U39_10590	COG1309	transcriptional regulator
E3U39_10595	COG2246	polysaccharide biosynthetic process
E3U39_10600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E3U39_10605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
E3U39_10610	COG2261	transglycosylase associated protein
E3U39_10615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E3U39_10620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E3U39_10640	COG0454	-acetyltransferase
E3U39_10645	COG0772	Belongs to the SEDS family
E3U39_10650	COG0778	Nitroreductase
E3U39_10655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3U39_10660	COG1404	Belongs to the peptidase S8 family
E3U39_10670	COG3711	transcriptional antiterminator
E3U39_10675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E3U39_10675	COG1263	PTS System
E3U39_10680	COG1621	beta-fructofuranosidase activity
E3U39_10690	COG0351	phosphomethylpyrimidine kinase
E3U39_10695	COG1216	Glycosyl transferase, family 2
E3U39_10710	COG2233	PERMEase
E3U39_10715	COG2363	Small membrane protein
E3U39_10725	COG0463	Glycosyl transferase, family 2
E3U39_10730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3U39_10735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U39_10740	COG0456	acetyltransferase
E3U39_10745	COG2089	acid synthase
E3U39_10750	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E3U39_10755	COG3980	spore coat polysaccharide biosynthesis protein
E3U39_10760	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E3U39_10765	COG1088	dTDP-glucose 4,6-dehydratase activity
E3U39_10770	COG1091	dTDP-4-dehydrorhamnose reductase activity
E3U39_10775	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E3U39_10785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3U39_10790	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_10795	COG4187	Peptidase family M20/M25/M40
E3U39_10800	COG0833	amino acid
E3U39_10805	COG2814	Major facilitator Superfamily
E3U39_10810	COG2814	Major facilitator Superfamily
E3U39_10840	COG0436	Aminotransferase
E3U39_10845	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_10855	COG0280	phosphate acetyltransferase
E3U39_10860	COG2855	membrane
E3U39_10865	COG0583	DNA-binding transcription factor activity
E3U39_10895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E3U39_10900	COG1131	(ABC) transporter
E3U39_10910	COG1695	Transcriptional regulator
E3U39_10925	COG1078	dGTPase activity
E3U39_10930	COG3465	dGTPase activity
E3U39_10935	COG0531	amino acid
E3U39_10945	COG1846	Transcriptional regulator
E3U39_10950	COG1942	4-Oxalocrotonate Tautomerase
E3U39_10955	COG1994	Peptidase M50
E3U39_10970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3U39_10975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E3U39_10980	COG0010	Belongs to the arginase family
E3U39_11025	COG0457	Tetratricopeptide repeat
E3U39_11030	COG4506	Protein conserved in bacteria
E3U39_11040	COG2223	nitrite transmembrane transporter activity
E3U39_11045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3U39_11055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E3U39_11060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E3U39_11065	COG1140	nitrate reductase beta subunit
E3U39_11070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E3U39_11075	COG2181	nitrate reductase activity
E3U39_11085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U39_11090	COG1132	(ABC) transporter
E3U39_11105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U39_11110	COG2181	nitrate reductase activity
E3U39_11110	COG0247	lactate metabolic process
E3U39_11125	COG4821	SIS domain
E3U39_11130	COG2204	response regulator
E3U39_11135	COG0191	fructose-bisphosphate aldolase activity
E3U39_11145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3U39_11150	COG1494	fructose-1,6-bisphosphatase
E3U39_11155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E3U39_11160	COG0254	rRNA binding
E3U39_11170	COG0281	malic enzyme
E3U39_11175	COG0679	Auxin Efflux Carrier
E3U39_11180	COG0789	Transcriptional regulator
E3U39_11185	COG0346	lactoylglutathione lyase activity
E3U39_11190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E3U39_11195	COG2890	protein-(glutamine-N5) methyltransferase activity
E3U39_11215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E3U39_11220	COG0009	L-threonylcarbamoyladenylate synthase
E3U39_11230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E3U39_11235	COG0698	ribose 5-phosphate isomerase
E3U39_11265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E3U39_11305	COG4836	Membrane
E3U39_11315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E3U39_11320	COG2385	sporulation resulting in formation of a cellular spore
E3U39_11330	COG2304	oxidoreductase activity
E3U39_11335	COG2304	oxidoreductase activity
E3U39_11340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E3U39_11350	COG0457	Tetratricopeptide repeat
E3U39_11355	COG1994	Peptidase M50
E3U39_11360	COG3237	CsbD-like
E3U39_11365	COG0831	urea catabolic process
E3U39_11380	COG1959	2 iron, 2 sulfur cluster binding
E3U39_11390	COG0726	polysaccharide deacetylase
E3U39_11400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E3U39_11415	COG1247	-acetyltransferase
E3U39_11420	COG0739	heme binding
E3U39_11430	COG0671	phosphoesterase, PA-phosphatase related
E3U39_11435	COG0772	Belongs to the SEDS family
E3U39_11440	COG0347	Belongs to the P(II) protein family
E3U39_11445	COG0004	ammonium transporteR
E3U39_11450	COG1335	isochorismatase
E3U39_11455	COG0477	Major facilitator Superfamily
E3U39_11460	COG1953	Uracil, thiamine, allantoin
E3U39_11465	COG2814	Major facilitator Superfamily
E3U39_11470	COG1846	Transcriptional regulator
E3U39_11475	COG1609	Transcriptional regulator
E3U39_11480	COG1077	Cell shape determining protein MreB Mrl
E3U39_11485	COG4786	Flagellar basal body rod
E3U39_11490	COG4786	Flagellar basal body rod
E3U39_11495	COG0457	Tetratricopeptide repeat
E3U39_11520	COG0629	single-stranded DNA binding
E3U39_11525	COG1349	DNA-binding transcription factor activity
E3U39_11530	COG0561	phosphatase activity
E3U39_11535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3U39_11540	COG4715	Zinc finger, swim domain protein
E3U39_11555	COG3944	biosynthesis protein
E3U39_11560	COG0489	protein tyrosine kinase activity
E3U39_11565	COG4464	protein tyrosine phosphatase activity
E3U39_11570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E3U39_11575	COG3878	Protein conserved in bacteria
E3U39_11590	COG5444	nuclease activity
E3U39_11645	COG2059	Chromate
E3U39_11650	COG2059	Chromate
E3U39_11655	COG1522	sequence-specific DNA binding
E3U39_11660	COG0405	Gamma-glutamyltransferase
E3U39_11670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E3U39_11680	COG5337	Spore coat protein CotH
E3U39_11695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E3U39_11700	COG0583	DNA-binding transcription factor activity
E3U39_11705	COG0028	Belongs to the TPP enzyme family
E3U39_11710	COG3527	Alpha-acetolactate decarboxylase
E3U39_11715	COG2249	NAD(P)H dehydrogenase (quinone) activity
E3U39_11720	COG3103	Sh3 type 3 domain protein
E3U39_11725	COG1879	ABC-type sugar transport system periplasmic component
E3U39_11730	COG1172	Belongs to the binding-protein-dependent transport system permease family
E3U39_11735	COG1129	ABC transporter
E3U39_11745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3U39_11750	COG1609	Transcriptional regulator
E3U39_11760	COG0814	amino acid
E3U39_11765	COG0697	spore germination
E3U39_11775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E3U39_11785	COG2843	Capsule synthesis protein
E3U39_11790	COG0791	NLP P60 protein
E3U39_11795	COG2433	Pfam Transposase IS66
E3U39_11800	COG0561	phosphatase activity
E3U39_11805	COG1316	TRANSCRIPTIONal
E3U39_11810	COG2814	Major facilitator Superfamily
E3U39_11815	COG1215	transferase activity, transferring glycosyl groups
E3U39_11825	COG0814	amino acid
E3U39_11830	COG0697	spore germination
E3U39_11835	COG1482	cell wall glycoprotein biosynthetic process
E3U39_11840	COG4193	domain, Protein
E3U39_11845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3U39_11850	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E3U39_11855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E3U39_11865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E3U39_11870	COG1682	transport, permease protein
E3U39_11875	COG1134	teichoic acid transport
E3U39_11880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3U39_11885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E3U39_11890	COG1316	TRANSCRIPTIONal
E3U39_11900	COG2385	sporulation resulting in formation of a cellular spore
E3U39_11900	COG2247	cell wall binding repeat
E3U39_11905	COG2247	cell wall binding repeat
E3U39_11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_11915	COG2244	polysaccharide biosynthetic process
E3U39_11920	COG0438	transferase activity, transferring glycosyl groups
E3U39_11920	COG0297	glycogen (starch) synthase activity
E3U39_11930	COG3307	-O-antigen
E3U39_11935	COG3206	protein involved in exopolysaccharide biosynthesis
E3U39_11940	COG1215	transferase activity, transferring glycosyl groups
E3U39_11945	COG0438	transferase activity, transferring glycosyl groups
E3U39_11950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E3U39_11955	COG1316	TRANSCRIPTIONal
E3U39_11960	COG1739	Uncharacterized protein family UPF0029
E3U39_11965	COG4585	Histidine kinase
E3U39_11970	COG2197	response regulator
E3U39_11975	COG1307	EDD domain protein, DegV family
E3U39_11980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
E3U39_11990	COG1040	competence protein
E3U39_12000	COG2747	anti-sigma28 factor FlgM
E3U39_12005	COG3418	PFAM FlgN family protein
E3U39_12010	COG1256	bacterial-type flagellum assembly
E3U39_12010	COG4786	Flagellar basal body rod
E3U39_12015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3U39_12035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E3U39_12040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E3U39_12045	COG1516	flagellar protein fliS
E3U39_12060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E3U39_12075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_12080	COG2010	Cytochrome c
E3U39_12085	COG2884	Cell division ATP-binding protein ftsE
E3U39_12090	COG2177	Part of the ABC transporter FtsEX involved in
E3U39_12095	COG3420	alginic acid biosynthetic process
E3U39_12100	COG0793	Belongs to the peptidase S41A family
E3U39_12100	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_12110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U39_12155	COG2814	Major facilitator Superfamily
E3U39_12160	COG1309	transcriptional regulator
E3U39_12165	COG0574	Belongs to the PEP-utilizing enzyme family
E3U39_12165	COG3848	Pyruvate phosphate dikinase
E3U39_12170	COG4897	Protein conserved in bacteria
E3U39_12180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E3U39_12195	COG3595	metallopeptidase activity
E3U39_12200	COG1983	PspC domain protein
E3U39_12205	COG1950	PFAM Membrane protein of
E3U39_12210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3U39_12215	COG1309	transcriptional regulator
E3U39_12230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E3U39_12250	COG0110	maltose O-acetyltransferase activity
E3U39_12255	COG4990	cell redox homeostasis
E3U39_12270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E3U39_12295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E3U39_12295	COG0140	phosphoribosyl-ATP diphosphatase activity
E3U39_12300	COG1132	(ABC) transporter
E3U39_12310	COG0745	RESPONSE REGULATOR receiver
E3U39_12315	COG5002	protein histidine kinase activity
E3U39_12320	COG0457	Tetratricopeptide repeat
E3U39_12325	COG3883	PFAM NLP P60 protein
E3U39_12325	COG0791	NLP P60 protein
E3U39_12330	COG0492	ferredoxin-NADP+ reductase activity
E3U39_12335	COG1051	belongs to the nudix hydrolase family
E3U39_12345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E3U39_12355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_12360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E3U39_12365	COG4290	ribonuclease
E3U39_12370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E3U39_12380	COG0288	reversible hydration of carbon dioxide
E3U39_12385	COG0659	secondary active sulfate transmembrane transporter activity
E3U39_12390	COG1694	Mazg nucleotide pyrophosphohydrolase
E3U39_12395	COG1611	Belongs to the LOG family
E3U39_12400	COG2814	Major facilitator Superfamily
E3U39_12400	COG0477	Major facilitator Superfamily
E3U39_12405	COG2828	Protein conserved in bacteria
E3U39_12410	COG0583	DNA-binding transcription factor activity
E3U39_12420	COG1609	Transcriptional regulator
E3U39_12425	COG2223	nitrite transmembrane transporter activity
E3U39_12465	COG3479	Phenolic acid decarboxylase
E3U39_12470	COG0456	acetyltransferase
E3U39_12475	COG2364	Membrane
E3U39_12480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3U39_12485	COG2272	Belongs to the type-B carboxylesterase lipase family
E3U39_12490	COG1396	sequence-specific DNA binding
E3U39_12495	COG3944	biosynthesis protein
E3U39_12500	COG0489	protein tyrosine kinase activity
E3U39_12505	COG1086	Polysaccharide biosynthesis protein
E3U39_12510	COG0438	transferase activity, transferring glycosyl groups
E3U39_12515	COG1215	transferase activity, transferring glycosyl groups
E3U39_12520	COG0438	transferase activity, transferring glycosyl groups
E3U39_12530	COG1216	Glycosyl transferase, family 2
E3U39_12535	COG5039	Polysaccharide pyruvyl transferase
E3U39_12540	COG1216	Glycosyl transferase, family 2
E3U39_12545	COG2244	polysaccharide biosynthetic process
E3U39_12550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E3U39_12555	COG0110	maltose O-acetyltransferase activity
E3U39_12560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U39_12565	COG5039	Polysaccharide pyruvyl transferase
E3U39_12575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E3U39_12580	COG1620	l-lactate permease
E3U39_12585	COG2186	Transcriptional regulator
E3U39_12590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E3U39_12615	COG1070	Carbohydrate kinase
E3U39_12620	COG1737	Transcriptional regulator
E3U39_12625	COG0561	phosphatase activity
E3U39_12635	COG1609	Transcriptional regulator
E3U39_12645	COG1113	amino acid transport
E3U39_12650	COG0697	spore germination
E3U39_12655	COG0583	DNA-binding transcription factor activity
E3U39_12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3U39_12670	COG1609	Transcriptional regulator
E3U39_12675	COG2814	Major facilitator Superfamily
E3U39_12680	COG2390	Transcriptional regulator
E3U39_12685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3U39_12695	COG0126	phosphoglycerate kinase activity
E3U39_12715	COG2234	aminopeptidase activity
E3U39_12725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U39_12730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_12735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E3U39_12750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3U39_12765	COG0456	acetyltransferase
E3U39_12770	COG4640	response to antibiotic
E3U39_12775	COG3064	Membrane
E3U39_12785	COG2095	MarC family integral membrane protein
E3U39_12790	COG1510	regulation of RNA biosynthetic process
E3U39_12795	COG0517	IMP dehydrogenase activity
E3U39_12795	COG1125	glycine betaine transport
E3U39_12800	COG1174	glycine betaine transport
E3U39_12805	COG1732	Glycine betaine
E3U39_12810	COG1174	glycine betaine transport
E3U39_12815	COG1510	regulation of RNA biosynthetic process
E3U39_12820	COG1125	glycine betaine transport
E3U39_12820	COG0517	IMP dehydrogenase activity
E3U39_12825	COG1174	glycine betaine transport
E3U39_12830	COG1732	Glycine betaine
E3U39_12835	COG1174	glycine betaine transport
E3U39_12900	COG1733	regulation of RNA biosynthetic process
E3U39_12905	COG1396	sequence-specific DNA binding
E3U39_12910	COG1396	sequence-specific DNA binding
E3U39_12915	COG1476	TRANSCRIPTIONal
E3U39_12920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E3U39_12925	COG1647	Serine aminopeptidase, S33
E3U39_12930	COG0557	exoribonuclease II activity
E3U39_12950	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_12955	COG0583	DNA-binding transcription factor activity
E3U39_12960	COG0454	-acetyltransferase
E3U39_12965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_12975	COG0765	amino acid transport
E3U39_12980	COG0765	amino acid transport
E3U39_12985	COG1126	abc transporter atp-binding protein
E3U39_12990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3U39_12995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E3U39_13000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E3U39_13015	COG2814	Major facilitator Superfamily
E3U39_13035	COG0673	inositol 2-dehydrogenase activity
E3U39_13040	COG1937	Protein conserved in bacteria
E3U39_13045	COG2608	mercury ion transmembrane transporter activity
E3U39_13050	COG2217	Heavy metal translocating P-type atpase
E3U39_13055	COG2217	Heavy metal translocating P-type atpase
E3U39_13060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E3U39_13065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E3U39_13075	COG2860	membrane
E3U39_13080	COG3973	AAA domain
E3U39_13085	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3U39_13110	COG0656	L-ascorbic acid biosynthetic process
E3U39_13115	COG0842	Transport permease protein
E3U39_13125	COG1131	(ABC) transporter
E3U39_13130	COG3850	Histidine kinase
E3U39_13135	COG2197	response regulator
E3U39_13140	COG4149	molybdate abc transporter
E3U39_13145	COG0725	ABC transporter, periplasmic molybdate-binding protein
E3U39_13150	COG1910	domain protein
E3U39_13155	COG1368	sulfuric ester hydrolase activity
E3U39_13160	COG1988	membrane-bound metal-dependent
E3U39_13175	COG0531	amino acid
E3U39_13180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E3U39_13185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U39_13190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_13195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_13200	COG1120	ATPase activity
E3U39_13210	COG2140	Oxalate decarboxylase
E3U39_13220	COG1191	sigma factor activity
E3U39_13230	COG0745	RESPONSE REGULATOR receiver
E3U39_13235	COG2205	protein histidine kinase activity
E3U39_13240	COG3386	PFAM SMP-30 Gluconolaconase
E3U39_13245	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_13250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E3U39_13255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E3U39_13260	COG1120	ATPase activity
E3U39_13265	COG2096	Adenosyltransferase
E3U39_13270	COG2814	Major facilitator Superfamily
E3U39_13275	COG4758	membrane
E3U39_13280	COG1842	Phage shock protein A
E3U39_13285	COG3595	metallopeptidase activity
E3U39_13290	COG4758	membrane
E3U39_13295	COG4585	Histidine kinase
E3U39_13300	COG2197	response regulator
E3U39_13310	COG0814	amino acid
E3U39_13315	COG0697	spore germination
E3U39_13325	COG0114	fumarate hydratase activity
E3U39_13330	COG1309	transcriptional regulator
E3U39_13340	COG2205	protein histidine kinase activity
E3U39_13340	COG2770	Histidine kinase
E3U39_13345	COG0745	RESPONSE REGULATOR receiver
E3U39_13355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E3U39_13360	COG0783	Belongs to the Dps family
E3U39_13365	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_13380	COG1120	ATPase activity
E3U39_13400	COG0583	DNA-binding transcription factor activity
E3U39_13415	COG0583	DNA-binding transcription factor activity
E3U39_13420	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_13425	COG1942	4-Oxalocrotonate Tautomerase
E3U39_13430	COG0477	Major facilitator Superfamily
E3U39_13435	COG1846	Transcriptional regulator
E3U39_13440	COG5577	PFAM Coat F domain
E3U39_13450	COG0477	Major facilitator Superfamily
E3U39_13465	COG1024	Enoyl-CoA hydratase
E3U39_13465	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3U39_13470	COG0183	Belongs to the thiolase family
E3U39_13475	COG1960	acyl-CoA dehydrogenase activity
E3U39_13480	COG1393	Belongs to the ArsC family
E3U39_13495	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
E3U39_13500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_13510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E3U39_13515	COG2011	ABC-type metal ion transport system permease component
E3U39_13520	COG1464	Belongs to the NlpA lipoprotein family
E3U39_13525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E3U39_13535	COG0396	ATPase activity
E3U39_13540	COG0719	Fe-S assembly protein
E3U39_13545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E3U39_13550	COG0822	iron-sulfur transferase activity
E3U39_13555	COG0719	Fe-S assembly protein
E3U39_13560	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_13570	COG2226	methyltransferase
E3U39_13575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E3U39_13580	COG0322	excinuclease ABC activity
E3U39_13595	COG0789	Transcriptional regulator
E3U39_13600	COG2222	sugar isomerase
E3U39_13605	COG1653	transport
E3U39_13610	COG1175	transmembrane transport
E3U39_13615	COG0395	ABC-type sugar transport system, permease component
E3U39_13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E3U39_13625	COG2188	Transcriptional regulator
E3U39_13630	COG3842	ATPase activity
E3U39_13635	COG2356	endonuclease I
E3U39_13640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3U39_13645	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E3U39_13650	COG2814	Major facilitator Superfamily
E3U39_13690	COG2508	Transcriptional regulator
E3U39_13705	COG1801	Protein of unknown function DUF72
E3U39_13710	COG0730	response to heat
E3U39_13715	COG0737	Belongs to the 5'-nucleotidase family
E3U39_13725	COG0739	heme binding
E3U39_13740	COG4470	Protein conserved in bacteria
E3U39_13745	COG2445	Protein of unknown function DUF86
E3U39_13750	COG0647	UMP catabolic process
E3U39_13755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E3U39_13760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3U39_13765	COG0460	homoserine dehydrogenase
E3U39_13770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E3U39_13780	COG4946	Tricorn protease homolog
E3U39_13780	COG0823	Involved in the tonB-independent uptake of proteins
E3U39_13780	COG1506	peptidase
E3U39_13785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E3U39_13790	COG4837	Protein of unknown function (DUF1462)
E3U39_13795	COG1252	NADH dehydrogenase
E3U39_13805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E3U39_13815	COG0316	Belongs to the HesB IscA family
E3U39_13820	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E3U39_13825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_13845	COG1131	(ABC) transporter
E3U39_13875	COG1252	NADH dehydrogenase
E3U39_13890	COG3584	3D domain protein
E3U39_13895	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
E3U39_13905	COG2056	Na+-H+ antiporter family
E3U39_13910	COG1268	BioY protein
E3U39_13915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E3U39_13920	COG2819	hydrolase of the alpha beta superfamily
E3U39_13925	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_13930	COG1169	isochorismate synthase
E3U39_13935	COG1021	2,3-dihydroxybenzoate-AMP ligase
E3U39_13940	COG1535	isochorismatase
E3U39_13940	COG3433	isochorismatase activity
E3U39_13945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_13950	COG3251	PFAM MbtH domain protein
E3U39_13955	COG5634	Uncharacterized conserved protein (DUF2278)
E3U39_13960	COG0686	Belongs to the AlaDH PNT family
E3U39_13965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E3U39_13965	COG2508	Transcriptional regulator
E3U39_13970	COG4842	Belongs to the WXG100 family
E3U39_13975	COG5417	Belongs to the EsaB family
E3U39_13980	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3U39_13985	COG0433	COG0433 Predicted ATPase
E3U39_13985	COG1674	ftsk spoiiie
E3U39_13990	COG1511	domain protein
E3U39_14000	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_14005	COG1418	mRNA catabolic process
E3U39_14015	COG0628	permease
E3U39_14030	COG5506	Protein of unknown function (DUF1694)
E3U39_14035	COG1335	isochorismatase
E3U39_14040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E3U39_14045	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E3U39_14065	COG0142	geranyltranstransferase activity
E3U39_14075	COG4585	Histidine kinase
E3U39_14080	COG2197	response regulator
E3U39_14085	COG2050	protein possibly involved in aromatic compounds catabolism
E3U39_14090	COG1320	monovalent cation:proton antiporter activity
E3U39_14095	COG2212	antiporter activity
E3U39_14100	COG1863	multisubunit Na H antiporter MnhE subunit
E3U39_14105	COG0651	ATP synthesis coupled electron transport
E3U39_14110	COG1006	Multisubunit Na H antiporter MnhC subunit
E3U39_14115	COG2111	Na H antiporter
E3U39_14120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E3U39_14120	COG2111	Na H antiporter
E3U39_14150	COG4565	transcriptional regulatory protein
E3U39_14155	COG3290	protein histidine kinase activity
E3U39_14165	COG3011	Protein conserved in bacteria
E3U39_14170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3U39_14175	COG2814	Major facilitator Superfamily
E3U39_14180	COG5018	Exonuclease
E3U39_14190	COG2205	protein histidine kinase activity
E3U39_14195	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E3U39_14205	COG2267	carboxylic ester hydrolase activity
E3U39_14210	COG1522	sequence-specific DNA binding
E3U39_14215	COG0436	Aminotransferase
E3U39_14220	COG1098	S1 RNA binding domain
E3U39_14225	COG2155	Conserved Protein
E3U39_14230	COG1979	alcohol dehydrogenase
E3U39_14235	COG1979	alcohol dehydrogenase
E3U39_14240	COG1335	isochorismatase
E3U39_14270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E3U39_14285	COG2738	Putative neutral zinc metallopeptidase
E3U39_14290	COG1253	flavin adenine dinucleotide binding
E3U39_14295	COG0366	Alpha amylase catalytic
E3U39_14300	COG0432	Pfam Uncharacterised protein family UPF0047
E3U39_14305	COG2070	2-Nitropropane dioxygenase
E3U39_14320	COG0840	transmembrane signaling receptor activity
E3U39_14325	COG0840	transmembrane signaling receptor activity
E3U39_14330	COG0840	transmembrane signaling receptor activity
E3U39_14335	COG0840	transmembrane signaling receptor activity
E3U39_14340	COG0693	protein deglycase activity
E3U39_14345	COG0673	inositol 2-dehydrogenase activity
E3U39_14350	COG0628	permease
E3U39_14365	COG0582	viral genome integration into host DNA
E3U39_14510	COG0739	heme binding
E3U39_14510	COG0741	lytic transglycosylase activity
E3U39_14510	COG1196	nuclear chromosome segregation
E3U39_14515	COG2433	Pfam Transposase IS66
E3U39_14575	COG1017	nitric oxide dioxygenase activity
E3U39_14575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3U39_14580	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3U39_14585	COG0569	domain protein
E3U39_14595	COG1510	regulation of RNA biosynthetic process
E3U39_14605	COG1454	alcohol dehydrogenase
E3U39_14615	COG2318	DinB family
E3U39_14620	COG1585	Membrane protein implicated in regulation of membrane protease activity
E3U39_14625	COG2268	Band 7 protein
E3U39_14630	COG3859	Proton-coupled thiamine transporter YuaJ
E3U39_14765	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E3U39_14770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3U39_14775	COG1169	isochorismate synthase
E3U39_14785	COG0596	Alpha beta hydrolase
E3U39_14790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E3U39_14800	COG4948	Mandelate Racemase Muconate Lactonizing
E3U39_14810	COG1294	oxidase, subunit
E3U39_14815	COG1271	oxidase subunit
E3U39_14825	COG0288	reversible hydration of carbon dioxide
E3U39_14850	COG0783	Belongs to the Dps family
E3U39_14855	COG4824	toxin secretion phage lysis holin
E3U39_14860	COG0494	nUDIX hydrolase
E3U39_14865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E3U39_14870	COG1116	anion transmembrane transporter activity
E3U39_14875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E3U39_14880	COG1506	peptidase
E3U39_14900	COG0367	asparagine synthase
E3U39_14905	COG1113	amino acid transport
E3U39_14910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E3U39_14915	COG2267	carboxylic ester hydrolase activity
E3U39_14925	COG0584	glycerophosphoryl diester phosphodiesterase
E3U39_14935	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E3U39_14940	COG1242	4 iron, 4 sulfur cluster binding
E3U39_14945	COG0477	Major facilitator Superfamily
E3U39_14960	COG1725	Transcriptional regulator
E3U39_14965	COG1131	(ABC) transporter
E3U39_14985	COG1136	(ABC) transporter
E3U39_14990	COG0577	efflux transmembrane transporter activity
E3U39_14995	COG0745	RESPONSE REGULATOR receiver
E3U39_15000	COG2205	protein histidine kinase activity
E3U39_15005	COG1136	(ABC) transporter
E3U39_15010	COG0577	efflux transmembrane transporter activity
E3U39_15015	COG5522	Integral membrane protein (intg_mem_TP0381)
E3U39_15020	COG2814	Major facilitator Superfamily
E3U39_15025	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_15025	COG2202	Pas domain
E3U39_15040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U39_15050	COG1486	melibiose metabolic process
E3U39_15080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E3U39_15085	COG2081	HI0933 family
E3U39_15090	COG2244	polysaccharide biosynthetic process
E3U39_15095	COG1187	pseudouridine synthase activity
E3U39_15100	COG1349	DNA-binding transcription factor activity
E3U39_15105	COG1131	(ABC) transporter
E3U39_15110	COG4473	ABC transporter
E3U39_15115	COG2252	PERMEase
E3U39_15120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3U39_15125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3U39_15130	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E3U39_15140	COG1597	lipid kinase activity
E3U39_15145	COG0510	thiamine kinase activity
E3U39_15160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_15165	COG0281	malic enzyme
E3U39_15170	COG5584	Small secreted protein
E3U39_15175	COG1363	Peptidase, m42
E3U39_15185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_15195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U39_15200	COG1674	ftsk spoiiie
E3U39_15210	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
E3U39_15215	COG4980	gas vesicle protein
E3U39_15220	COG3118	belongs to the thioredoxin family
E3U39_15225	COG1605	Chorismate mutase
E3U39_15225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E3U39_15230	COG1609	Transcriptional regulator
E3U39_15235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E3U39_15240	COG1360	Flagellar Motor Protein
E3U39_15245	COG0123	including yeast histone deacetylase and acetoin utilization protein
E3U39_15250	COG0517	IMP dehydrogenase activity
E3U39_15255	COG0454	-acetyltransferase
E3U39_15260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3U39_15285	COG1378	Sugar-specific transcriptional regulator TrmB
E3U39_15290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E3U39_15305	COG0693	protein deglycase activity
E3U39_15315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E3U39_15315	COG1017	nitric oxide dioxygenase activity
E3U39_15325	COG4282	regulation of fungal-type cell wall biogenesis
E3U39_15330	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_15345	COG2203	Gaf domain
E3U39_15345	COG2199	diguanylate cyclase activity
E3U39_15350	COG1956	GAF domain-containing protein
E3U39_15355	COG1309	transcriptional regulator
E3U39_15360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3U39_15370	COG1114	Component of the transport system for branched-chain amino acids
E3U39_15375	COG1104	cysteine desulfurase activity
E3U39_15390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E3U39_15395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E3U39_15400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E3U39_15405	COG0616	signal peptide processing
E3U39_15410	COG1714	RDD family
E3U39_15420	COG3874	Sporulation protein YtfJ
E3U39_15425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E3U39_15430	COG0827	DNA restriction-modification system
E3U39_15440	COG0521	Mo-molybdopterin cofactor biosynthetic process
E3U39_15455	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_15465	COG4109	DRTGG domain
E3U39_15475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E3U39_15495	COG0587	DNA-directed DNA polymerase activity
E3U39_15500	COG0281	malic enzyme
E3U39_15520	COG0469	pyruvate kinase activity
E3U39_15525	COG3030	protein affecting phage T7 exclusion by the F plasmid
E3U39_15530	COG0628	permease
E3U39_15545	COG0372	Belongs to the citrate synthase family
E3U39_15550	COG0538	isocitrate dehydrogenase activity
E3U39_15560	COG0745	RESPONSE REGULATOR receiver
E3U39_15565	COG5002	protein histidine kinase activity
E3U39_15570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3U39_15570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3U39_15575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E3U39_15580	COG1971	Probably functions as a manganese efflux pump
E3U39_15585	COG0237	dephospho-CoA kinase activity
E3U39_15590	COG0656	L-ascorbic acid biosynthetic process
E3U39_15595	COG2814	Major facilitator Superfamily
E3U39_15600	COG1733	regulation of RNA biosynthetic process
E3U39_15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E3U39_15620	COG3611	Membrane attachment protein
E3U39_15625	COG1484	DNA-dependent DNA replication
E3U39_15630	COG0398	Pfam SNARE associated Golgi protein
E3U39_15650	COG3275	phosphorelay sensor kinase activity
E3U39_15655	COG3279	Response regulator of the LytR AlgR family
E3U39_15660	COG1380	Effector of murein hydrolase LrgA
E3U39_15665	COG1346	cytolysis
E3U39_15670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E3U39_15680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E3U39_15685	COG3326	Membrane
E3U39_15695	COG1363	Peptidase, m42
E3U39_15700	COG3507	Belongs to the glycosyl hydrolase 43 family
E3U39_15705	COG2160	L-arabinose isomerase activity
E3U39_15710	COG1069	ribulokinase activity
E3U39_15715	COG0235	Class ii aldolase
E3U39_15720	COG0647	UMP catabolic process
E3U39_15730	COG1653	transport
E3U39_15735	COG1175	transmembrane transport
E3U39_15740	COG0395	ABC-type sugar transport system, permease component
E3U39_15745	COG3534	alpha-L-arabinofuranosidase
E3U39_15750	COG1966	Carbon starvation protein
E3U39_15755	COG0247	lactate metabolic process
E3U39_15760	COG0277	FAD linked oxidase domain protein
E3U39_15765	COG3835	regulator
E3U39_15775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E3U39_15780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E3U39_15785	COG0072	phenylalanine-tRNA ligase activity
E3U39_15785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U39_15800	COG1286	toxin biosynthetic process
E3U39_15805	COG1796	DNA polymerase
E3U39_15805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E3U39_15815	COG3766	membrane
E3U39_15825	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_15830	COG1309	transcriptional regulator
E3U39_15835	COG1024	Enoyl-CoA hydratase
E3U39_15840	COG2086	electron transfer activity
E3U39_15845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E3U39_15850	COG3534	alpha-L-arabinofuranosidase
E3U39_15855	COG3118	belongs to the thioredoxin family
E3U39_15870	COG0527	aspartate kinase activity
E3U39_15875	COG1719	4-vinyl reductase, 4VR
E3U39_15880	COG2009	succinate dehydrogenase
E3U39_15885	COG1053	succinate dehydrogenase
E3U39_15890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E3U39_15895	COG0824	Thioesterase
E3U39_15900	COG2197	response regulator
E3U39_15905	COG1846	Transcriptional regulator
E3U39_15915	COG5401	PFAM Sporulation and spore germination
E3U39_15925	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E3U39_15930	COG0622	Phosphoesterase
E3U39_15950	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E3U39_15960	COG0732	type I restriction modification DNA specificity domain
E3U39_15990	COG0028	Belongs to the TPP enzyme family
E3U39_15995	COG0440	acetolactate synthase activity
E3U39_16010	COG0473	3-isopropylmalate dehydrogenase activity
E3U39_16025	COG0457	Tetratricopeptide repeat
E3U39_16025	COG1477	protein flavinylation
E3U39_16040	COG1067	ATP-dependent peptidase activity
E3U39_16040	COG0470	DNA polymerase III
E3U39_16045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E3U39_16065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3U39_16075	COG1587	Uroporphyrinogen-III synthase
E3U39_16080	COG0113	porphobilinogen synthase activity
E3U39_16090	COG1388	LysM domain
E3U39_16095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E3U39_16105	COG0525	valine-tRNA ligase activity
E3U39_16110	COG0285	dihydrofolate synthase activity
E3U39_16115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E3U39_16135	COG1077	Cell shape determining protein MreB Mrl
E3U39_16140	COG1792	Involved in formation and maintenance of cell shape
E3U39_16145	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E3U39_16155	COG2894	cell division
E3U39_16160	COG0739	heme binding
E3U39_16165	COG1994	Peptidase M50
E3U39_16175	COG2868	ribosomal protein
E3U39_16180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E3U39_16185	COG3290	protein histidine kinase activity
E3U39_16200	COG0077	Prephenate dehydratase
E3U39_16205	COG1827	regulation of RNA biosynthetic process
E3U39_16210	COG1104	cysteine desulfurase activity
E3U39_16215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E3U39_16220	COG0157	Belongs to the NadC ModD family
E3U39_16230	COG1388	LysM domain
E3U39_16275	COG1862	Preprotein translocase
E3U39_16285	COG2323	membrane
E3U39_16290	COG2244	polysaccharide biosynthetic process
E3U39_16300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U39_16300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E3U39_16305	COG0490	domain, Protein
E3U39_16310	COG5416	Lipopolysaccharide assembly protein A domain
E3U39_16315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E3U39_16315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E3U39_16325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E3U39_16335	COG4991	sh3 domain protein
E3U39_16335	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_16335	COG3103	Sh3 type 3 domain protein
E3U39_16355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E3U39_16360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E3U39_16365	COG1959	2 iron, 2 sulfur cluster binding
E3U39_16370	COG1104	cysteine desulfurase activity
E3U39_16380	COG0457	Tetratricopeptide repeat
E3U39_16385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E3U39_16390	COG3881	PFAM PRC-barrel domain
E3U39_16405	COG0765	amino acid transport
E3U39_16410	COG0765	amino acid transport
E3U39_16415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_16420	COG1126	abc transporter atp-binding protein
E3U39_16425	COG0628	permease
E3U39_16435	COG4472	Bacterial protein of unknown function (DUF965)
E3U39_16450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3U39_16485	COG1396	sequence-specific DNA binding
E3U39_16600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E3U39_16605	COG0582	viral genome integration into host DNA
E3U39_16630	COG4626	Terminase
E3U39_16630	COG1802	Transcriptional regulator
E3U39_16705	COG1705	Flagellar rod assembly protein muramidase FlgJ
E3U39_16705	COG1388	LysM domain
E3U39_16710	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_16730	COG4824	toxin secretion phage lysis holin
E3U39_16735	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_16735	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3U39_16765	COG0768	penicillin binding
E3U39_16790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E3U39_16795	COG0626	cystathionine gamma-synthase activity
E3U39_16805	COG2427	Protein of unknown function (DUF1641)
E3U39_16810	COG3383	formate dehydrogenase (NAD+) activity
E3U39_16815	COG5609	conserved protein (DUF2294)
E3U39_16820	COG2116	formate transmembrane transporter activity
E3U39_16835	COG2226	methyltransferase
E3U39_16840	COG1309	transcriptional regulator
E3U39_16845	COG2124	cytochrome p450
E3U39_16845	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E3U39_16850	COG2814	Major facilitator Superfamily
E3U39_16855	COG0583	DNA-binding transcription factor activity
E3U39_16860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E3U39_16870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_16870	COG3711	transcriptional antiterminator
E3U39_16875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E3U39_16875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3U39_16875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E3U39_16880	COG1482	cell wall glycoprotein biosynthetic process
E3U39_16890	COG0561	phosphatase activity
E3U39_16895	COG0561	phosphatase activity
E3U39_16905	COG2318	DinB family
E3U39_16910	COG0456	acetyltransferase
E3U39_16920	COG2814	Major facilitator Superfamily
E3U39_16930	COG0563	adenylate kinase activity
E3U39_16935	COG0454	-acetyltransferase
E3U39_16945	COG2311	Membrane
E3U39_16950	COG0745	RESPONSE REGULATOR receiver
E3U39_16955	COG0642	Histidine kinase
E3U39_16955	COG5002	protein histidine kinase activity
E3U39_16985	COG0656	L-ascorbic acid biosynthetic process
E3U39_16995	COG0114	fumarate hydratase activity
E3U39_17005	COG1794	racemase activity, acting on amino acids and derivatives
E3U39_17030	COG0398	Pfam SNARE associated Golgi protein
E3U39_17035	COG0726	polysaccharide deacetylase
E3U39_17040	COG2755	lipolytic protein G-D-S-L family
E3U39_17050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E3U39_17055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
E3U39_17060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E3U39_17065	COG1534	Rna-binding protein
E3U39_17075	COG1713	HD superfamily hydrolase involved in NAD metabolism
E3U39_17080	COG0799	negative regulation of ribosome biogenesis
E3U39_17085	COG2226	methyltransferase
E3U39_17090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3U39_17095	COG1555	photosystem II stabilization
E3U39_17095	COG1596	polysaccharide export
E3U39_17100	COG2131	deaminase
E3U39_17105	COG2333	competence protein COMEC
E3U39_17105	COG0658	competence protein
E3U39_17120	COG1466	dna polymerase III delta subunit
E3U39_17135	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_17150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E3U39_17180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E3U39_17185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E3U39_17190	COG1283	sodium-dependent phosphate transmembrane transporter activity
E3U39_17195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E3U39_17200	COG1610	YqeY-like protein
E3U39_17205	COG1030	water channel activity
E3U39_17210	COG4864	UPF0365 protein
E3U39_17225	COG0561	phosphatase activity
E3U39_17230	COG1702	phosphate starvation-inducible protein PhoH
E3U39_17235	COG1480	7TM receptor with intracellular HD hydrolase
E3U39_17245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E3U39_17250	COG0295	cytidine deaminase activity
E3U39_17255	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E3U39_17275	COG0751	glycine-tRNA ligase activity
E3U39_17280	COG0517	IMP dehydrogenase activity
E3U39_17295	COG0358	DNA primase activity
E3U39_17300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E3U39_17305	COG2010	Cytochrome c
E3U39_17310	COG2384	SAM-dependent methyltransferase
E3U39_17315	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E3U39_17330	COG0513	Belongs to the DEAD box helicase family
E3U39_17345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_17350	COG0735	belongs to the Fur family
E3U39_17355	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
E3U39_17360	COG4709	membrane
E3U39_17370	COG1388	LysM domain
E3U39_17375	COG5521	maltodextrose utilization protein MalA
E3U39_17380	COG2839	Protein conserved in bacteria
E3U39_17385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3U39_17390	COG0477	Major facilitator Superfamily
E3U39_17400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E3U39_17405	COG0573	inorganic phosphate transmembrane transporter activity
E3U39_17410	COG0581	inorganic phosphate transmembrane transporter activity
E3U39_17415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U39_17420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E3U39_17425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E3U39_17435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E3U39_17440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E3U39_17450	COG1757	Na H antiporter
E3U39_17455	COG4483	Protein conserved in bacteria
E3U39_17460	COG1940	carbohydrate kinase activity
E3U39_17465	COG2866	Carboxypeptidase
E3U39_17475	COG0011	TIGRFAM Protein of
E3U39_17485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_17495	COG1393	Belongs to the ArsC family
E3U39_17505	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_17510	COG1253	flavin adenine dinucleotide binding
E3U39_17515	COG0598	Magnesium transport protein CorA
E3U39_17520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E3U39_17525	COG1459	type II secretion system
E3U39_17530	COG4537	Required for transformation and DNA binding
E3U39_17535	COG4970	Tfp pilus assembly protein FimT
E3U39_17545	COG4940	Competence protein ComGF
E3U39_17570	COG0681	Belongs to the peptidase S26 family
E3U39_17580	COG1396	sequence-specific DNA binding
E3U39_17595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E3U39_17615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E3U39_17630	COG1752	Esterase of the alpha-beta hydrolase superfamily
E3U39_17640	COG3872	metal-dependent enzyme
E3U39_17650	COG0006	proline dipeptidase activity
E3U39_17665	COG3854	ATPases associated with a variety of cellular activities
E3U39_17705	COG0511	ligase activity, forming carbon-carbon bonds
E3U39_17710	COG0439	Biotin carboxylase
E3U39_17715	COG1302	Protein conserved in bacteria
E3U39_17730	COG1570	exodeoxyribonuclease VII activity
E3U39_17740	COG0142	geranyltranstransferase activity
E3U39_17750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E3U39_17760	COG0497	DNA recombination
E3U39_17765	COG0750	zinc metalloprotease
E3U39_17770	COG0745	RESPONSE REGULATOR receiver
E3U39_17775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E3U39_17790	COG1902	pentaerythritol trinitrate reductase activity
E3U39_17815	COG0860	N-Acetylmuramoyl-L-alanine amidase
E3U39_17820	COG0584	glycerophosphoryl diester phosphodiesterase
E3U39_17825	COG0183	Belongs to the thiolase family
E3U39_17830	COG1250	3-hydroxyacyl-CoA dehydrogenase
E3U39_17835	COG1960	acyl-CoA dehydrogenase activity
E3U39_17840	COG0372	Belongs to the citrate synthase family
E3U39_17845	COG2079	MmgE PrpD family protein
E3U39_17850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E3U39_17860	COG3290	protein histidine kinase activity
E3U39_17860	COG3829	transcription factor binding
E3U39_17865	COG0280	phosphate acetyltransferase
E3U39_17870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3U39_17875	COG3426	butyrate kinase activity
E3U39_17880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E3U39_17885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E3U39_17890	COG0022	dehydrogenase e1 component
E3U39_17895	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U39_17900	COG1597	lipid kinase activity
E3U39_17915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E3U39_17920	COG0765	amino acid transport
E3U39_17925	COG1126	abc transporter atp-binding protein
E3U39_17930	COG4129	membrane
E3U39_17935	COG1376	ErfK ybiS ycfS ynhG family protein
E3U39_17940	COG0346	lactoylglutathione lyase activity
E3U39_17945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3U39_17950	COG2195	Cleaves the N-terminal amino acid of tripeptides
E3U39_17955	COG0706	membrane insertase activity
E3U39_17970	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E3U39_17975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E3U39_17990	COG0596	Alpha beta hydrolase
E3U39_18010	COG0250	Participates in transcription elongation, termination and antitermination
E3U39_18020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E3U39_18020	COG2070	2-Nitropropane dioxygenase
E3U39_18035	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_18040	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18045	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18045	COG3321	synthase
E3U39_18045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_18045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_18045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18050	COG0300	oxidoreductase activity
E3U39_18050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18050	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18050	COG3321	synthase
E3U39_18050	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_18055	COG3321	synthase
E3U39_18055	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_18055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_18055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18060	COG3321	synthase
E3U39_18060	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18060	COG0300	oxidoreductase activity
E3U39_18060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18060	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_18065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18065	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18065	COG3321	synthase
E3U39_18065	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_18065	COG0300	oxidoreductase activity
E3U39_18070	COG3321	synthase
E3U39_18070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18070	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_18070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_18075	COG3321	synthase
E3U39_18075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E3U39_18075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_18075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E3U39_18075	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_18080	COG2124	cytochrome p450
E3U39_18085	COG3425	synthase
E3U39_18090	COG1024	Enoyl-CoA hydratase
E3U39_18095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E3U39_18100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_18105	COG0300	oxidoreductase activity
E3U39_18110	COG3048	D-serine ammonia-lyase activity
E3U39_18120	COG0346	lactoylglutathione lyase activity
E3U39_18130	COG0628	permease
E3U39_18145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3U39_18150	COG0456	acetyltransferase
E3U39_18155	COG2329	Antibiotic biosynthesis monooxygenase
E3U39_18160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E3U39_18160	COG0456	acetyltransferase
E3U39_18165	COG4918	Iron-sulphur cluster biosynthesis
E3U39_18175	COG1073	alpha beta
E3U39_18185	COG0667	Aldo Keto reductase
E3U39_18195	COG0494	nUDIX hydrolase
E3U39_18200	COG1379	DNA repair
E3U39_18205	COG1396	sequence-specific DNA binding
E3U39_18210	COG0252	asparaginase activity
E3U39_18215	COG1027	Aspartate ammonia-lyase
E3U39_18220	COG1757	Na H antiporter
E3U39_18225	COG0281	malic enzyme
E3U39_18240	COG1300	Membrane
E3U39_18245	COG0735	belongs to the Fur family
E3U39_18255	COG4974	Belongs to the 'phage' integrase family
E3U39_18260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E3U39_18265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E3U39_18270	COG1686	Belongs to the peptidase S11 family
E3U39_18275	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_18285	COG1191	sigma factor activity
E3U39_18305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E3U39_18320	COG0697	spore germination
E3U39_18325	COG0019	diaminopimelate decarboxylase activity
E3U39_18330	COG4086	secreted protein
E3U39_18335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E3U39_18345	COG0681	Belongs to the peptidase S26 family
E3U39_18355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U39_18355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E3U39_18360	COG0307	riboflavin synthase, alpha
E3U39_18375	COG0456	acetyltransferase
E3U39_18385	COG1547	Domain of unknown function (DUF309)
E3U39_18410	COG1686	Belongs to the peptidase S11 family
E3U39_18415	COG2715	membrane protein required for spore maturation
E3U39_18420	COG0700	Nucleoside recognition
E3U39_18425	COG1187	pseudouridine synthase activity
E3U39_18430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_18435	COG1333	cytochrome c biogenesis protein
E3U39_18440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E3U39_18445	COG0745	RESPONSE REGULATOR receiver
E3U39_18450	COG5002	protein histidine kinase activity
E3U39_18455	COG1595	DNA-templated transcription, initiation
E3U39_18465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3U39_18470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E3U39_18475	COG1141	Ferredoxin
E3U39_18480	COG4955	Helix-turn-helix domain
E3U39_18485	COG0514	ATP-dependent DNA helicase (RecQ)
E3U39_18490	COG1266	CAAX protease self-immunity
E3U39_18495	COG1388	LysM domain
E3U39_18505	COG1408	metallophosphoesterase
E3U39_18510	COG4862	establishment of competence for transformation
E3U39_18515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E3U39_18520	COG0492	ferredoxin-NADP+ reductase activity
E3U39_18525	COG2339	peptidase activity
E3U39_18530	COG3773	Cell wall hydrolase
E3U39_18530	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_18535	COG2959	enzyme of heme biosynthesis
E3U39_18540	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E3U39_18550	COG0539	negative regulation of cytoplasmic translation
E3U39_18590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3U39_18595	COG0776	regulation of translation
E3U39_18610	COG0142	geranyltranstransferase activity
E3U39_18620	COG0142	geranyltranstransferase activity
E3U39_18625	COG0105	UTP biosynthetic process
E3U39_18630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E3U39_18645	COG4401	Chorismate mutase type I
E3U39_18650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E3U39_18685	COG0287	Prephenate dehydrogenase
E3U39_18700	COG0457	Tetratricopeptide repeat
E3U39_18715	COG0723	plastoquinol--plastocyanin reductase activity
E3U39_18720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3U39_18725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E3U39_18725	COG2010	Cytochrome c
E3U39_18730	COG4347	Protein of unknown function (DUF1405)
E3U39_18740	COG2140	Oxalate decarboxylase
E3U39_18745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E3U39_18750	COG1694	Mazg nucleotide pyrophosphohydrolase
E3U39_18765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3U39_18770	COG0438	transferase activity, transferring glycosyl groups
E3U39_18800	COG1199	ATP-dependent helicase activity
E3U39_18800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E3U39_18810	COG5353	protein conserved in bacteria
E3U39_18815	COG0436	Aminotransferase
E3U39_18825	COG3935	DnaD domain protein
E3U39_18830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E3U39_18840	COG4499	WXG100 protein secretion system (Wss), protein YukC
E3U39_18840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E3U39_18880	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U39_18885	COG2190	(PTS) system
E3U39_18890	COG1111	helicase
E3U39_18890	COG1205	dead DEAH box helicase
E3U39_18895	COG3359	exonuclease
E3U39_18925	COG0116	Belongs to the methyltransferase superfamily
E3U39_18940	COG1199	ATP-dependent helicase activity
E3U39_18945	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
E3U39_18965	COG1525	nuclease
E3U39_18970	COG4282	regulation of fungal-type cell wall biogenesis
E3U39_18975	COG5444	nuclease activity
E3U39_19015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E3U39_19020	COG0457	Tetratricopeptide repeat
E3U39_19040	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_19040	COG5632	N-Acetylmuramoyl-L-alanine amidase
E3U39_19045	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_19055	COG2433	Pfam Transposase IS66
E3U39_19065	COG0741	lytic transglycosylase activity
E3U39_19065	COG1196	nuclear chromosome segregation
E3U39_19065	COG0739	heme binding
E3U39_19085	COG0582	viral genome integration into host DNA
E3U39_19220	COG0776	regulation of translation
E3U39_19340	COG3655	Transcriptional regulator
E3U39_19345	COG3655	Transcriptional regulator
E3U39_19460	COG3655	Transcriptional regulator
E3U39_19525	COG4474	Belongs to the UPF0398 family
E3U39_19560	COG1793	dna ligase
E3U39_19565	COG2135	peptidase activity
E3U39_19585	COG4195	phage-related replication protein
E3U39_19590	COG3420	alginic acid biosynthetic process
E3U39_19590	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_19610	COG2404	hydrolase activity, acting on ester bonds
E3U39_19650	COG3584	3D domain protein
E3U39_19655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E3U39_19665	COG4133	protoheme IX ABC transporter activity
E3U39_19760	COG1780	Probably involved in ribonucleotide reductase function
E3U39_19765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U39_19765	COG1372	Participates in initiation and elongation during chromosome replication
E3U39_19775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E3U39_19785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_19795	COG0756	dUTP diphosphatase activity
E3U39_19815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E3U39_19820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3U39_19850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E3U39_19895	COG3331	DNA recombination
E3U39_19910	COG1335	isochorismatase
E3U39_19935	COG3424	synthase
E3U39_19940	COG1755	Isoprenylcysteine carboxyl methyltransferase
E3U39_19950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E3U39_19965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E3U39_19975	COG0328	RNA-DNA hybrid ribonuclease activity
E3U39_19980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E3U39_19985	COG0328	RNA-DNA hybrid ribonuclease activity
E3U39_20005	COG1278	Cold shock
E3U39_20015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E3U39_20025	COG0386	Belongs to the glutathione peroxidase family
E3U39_20030	COG1418	mRNA catabolic process
E3U39_20035	COG1413	lyase activity
E3U39_20050	COG2136	Putative SAM-dependent methyltransferase
E3U39_20050	COG2521	methyltransferase
E3U39_20065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E3U39_20070	COG0204	Acyl-transferase
E3U39_20075	COG1272	protein, Hemolysin III
E3U39_20080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E3U39_20085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E3U39_20095	COG1999	signal sequence binding
E3U39_20100	COG2755	lipolytic protein G-D-S-L family
E3U39_20105	COG4698	Protein conserved in bacteria
E3U39_20110	COG1846	Transcriptional regulator
E3U39_20130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3U39_20140	COG4282	regulation of fungal-type cell wall biogenesis
E3U39_20165	COG0457	Tetratricopeptide repeat
E3U39_20170	COG1388	LysM domain
E3U39_20230	COG1086	Polysaccharide biosynthesis protein
E3U39_20240	COG4641	Protein conserved in bacteria
E3U39_20255	COG0463	Glycosyl transferase, family 2
E3U39_20260	COG0456	acetyltransferase
E3U39_20270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E3U39_20275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3U39_20280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3U39_20285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3U39_20290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E3U39_20295	COG0456	acetyltransferase
E3U39_20300	COG1509	lysine 2,3-aminomutase activity
E3U39_20330	COG0671	phosphoesterase, PA-phosphatase related
E3U39_20350	COG1876	peptidase activity
E3U39_20360	COG2226	methyltransferase
E3U39_20365	COG3409	Peptidoglycan-binding domain 1 protein
E3U39_20365	COG0793	Belongs to the peptidase S41A family
E3U39_20370	COG2188	Transcriptional regulator
E3U39_20375	COG2723	6-phospho-beta-galactosidase activity
E3U39_20385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E3U39_20395	COG0346	lactoylglutathione lyase activity
E3U39_20400	COG0400	carboxylic ester hydrolase activity
E3U39_20405	COG0778	Nitroreductase
E3U39_20410	COG1733	regulation of RNA biosynthetic process
E3U39_20420	COG1942	4-Oxalocrotonate Tautomerase
E3U39_20435	COG2962	Rard protein
E3U39_20445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3U39_20450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E3U39_20455	COG1366	Belongs to the anti-sigma-factor antagonist family
E3U39_20460	COG0534	Mate efflux family protein
E3U39_20465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E3U39_20470	COG1819	glycosyl
E3U39_20475	COG1388	LysM domain
E3U39_20475	COG0791	NLP P60 protein
E3U39_20480	COG2032	superoxide dismutase activity
E3U39_20485	COG0714	Associated with various cellular activities
E3U39_20490	COG4548	von Willebrand factor, type A
E3U39_20500	COG0508	dehydrogenase complex catalyzes the overall conversion of
E3U39_20505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_20510	COG0385	Bile acid
E3U39_20515	COG0733	neurotransmitter:sodium symporter activity
E3U39_20520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E3U39_20525	COG1657	PFAM Prenyltransferase squalene oxidase
E3U39_20530	COG1012	belongs to the aldehyde dehydrogenase family
E3U39_20560	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U39_20575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E3U39_20580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E3U39_20590	COG0514	ATP-dependent DNA helicase (RecQ)
E3U39_20595	COG1388	LysM domain
E3U39_20595	COG3584	3D domain protein
E3U39_20605	COG1619	proteins homologs of microcin C7 resistance protein MccF
E3U39_20620	COG2322	membrane
E3U39_20625	COG0741	lytic transglycosylase activity
E3U39_20630	COG0640	Transcriptional regulator
E3U39_20640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E3U39_20645	COG1309	transcriptional regulator
E3U39_20650	COG2207	Transcriptional regulator
E3U39_20650	COG0662	Cupin 2, conserved barrel domain protein
E3U39_20655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E3U39_20660	COG5444	nuclease activity
E3U39_20690	COG0243	molybdopterin cofactor binding
E3U39_20695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E3U39_20700	COG1070	Carbohydrate kinase
E3U39_20705	COG2814	Major facilitator Superfamily
E3U39_20715	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
E3U39_20720	COG0300	oxidoreductase activity
E3U39_20735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E3U39_20740	COG0583	DNA-binding transcription factor activity
E3U39_20745	COG0070	glutamate synthase
E3U39_20745	COG0069	glutamate synthase activity
E3U39_20745	COG0067	glutamate synthase
E3U39_20750	COG0493	'glutamate synthase
E3U39_20755	COG0604	alcohol dehydrogenase
E3U39_20765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E3U39_20770	COG0640	Transcriptional regulator
E3U39_20775	COG2814	Major facilitator Superfamily
E3U39_20780	COG0405	Gamma-glutamyltransferase
E3U39_20785	COG0166	Belongs to the GPI family
E3U39_20790	COG0582	viral genome integration into host DNA
E3U39_20805	COG0534	Mate efflux family protein
E3U39_20810	COG2017	converts alpha-aldose to the beta-anomer
E3U39_20815	COG2027	D-alanyl-D-alanine carboxypeptidase
E3U39_20825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_20830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_20835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_20840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_20845	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E3U39_20845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E3U39_20855	COG1649	PFAM Uncharacterised BCR, COG1649
E3U39_20860	COG1960	acyl-CoA dehydrogenase activity
E3U39_20865	COG0318	PFAM AMP-dependent synthetase and ligase
E3U39_20870	COG0439	Biotin carboxylase
E3U39_20875	COG0511	ligase activity, forming carbon-carbon bonds
E3U39_20880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E3U39_20885	COG1024	Enoyl-CoA hydratase
E3U39_20890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E3U39_20895	COG0586	Pfam SNARE associated Golgi protein
E3U39_20900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E3U39_20905	COG2246	polysaccharide biosynthetic process
E3U39_20915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E3U39_20930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E3U39_20935	COG2124	cytochrome p450
E3U39_20940	COG2610	gluconate transmembrane transporter activity
E3U39_20945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E3U39_20950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E3U39_20955	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_20985	COG3507	Belongs to the glycosyl hydrolase 43 family
E3U39_20995	COG0745	RESPONSE REGULATOR receiver
E3U39_21000	COG2205	protein histidine kinase activity
E3U39_21040	COG2271	Major facilitator Superfamily
E3U39_21045	COG1609	Transcriptional regulator
E3U39_21050	COG1028	Short-chain dehydrogenase reductase Sdr
E3U39_21055	COG1312	Catalyzes the dehydration of D-mannonate
E3U39_21060	COG0800	Aldolase
E3U39_21065	COG1063	alcohol dehydrogenase
E3U39_21075	COG1115	amino acid carrier protein
E3U39_21085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E3U39_21090	COG0187	DNA topoisomerase II activity
E3U39_21095	COG1832	CoA-binding protein
E3U39_21105	COG4841	protein insertion into membrane
E3U39_21115	COG0824	Thioesterase
E3U39_21135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E3U39_21140	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E3U39_21155	COG0071	Belongs to the small heat shock protein (HSP20) family
E3U39_21165	COG4846	Membrane protein involved in cytochrome C biogenesis
E3U39_21170	COG2201	protein-glutamate methylesterase activity
E3U39_21175	COG0785	Cytochrome C biogenesis protein
E3U39_21195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E3U39_21205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E3U39_21235	COG4195	phage-related replication protein
E3U39_21245	COG0756	dUTP diphosphatase activity
E3U39_21250	COG5434	Belongs to the glycosyl hydrolase 28 family
E3U39_21260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E3U39_21270	COG3397	chitin binding
E3U39_21295	COG0456	acetyltransferase
E3U39_21320	COG1064	alcohol dehydrogenase
E3U39_21345	COG3848	Pyruvate phosphate dikinase
E3U39_21345	COG0574	Belongs to the PEP-utilizing enzyme family
E3U39_21350	COG1070	Carbohydrate kinase
E3U39_21365	COG3507	Belongs to the glycosyl hydrolase 43 family
E3U39_21370	COG2211	Major facilitator Superfamily