locus-tag	class	description
I3J23_00005	COG1819	glycosyl
I3J23_00010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I3J23_00015	COG0534	Mate efflux family protein
I3J23_00020	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_00025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J23_00030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J23_00040	COG2962	Rard protein
I3J23_00055	COG1942	4-Oxalocrotonate Tautomerase
I3J23_00065	COG1733	regulation of RNA biosynthetic process
I3J23_00070	COG0778	Nitroreductase
I3J23_00075	COG0400	carboxylic ester hydrolase activity
I3J23_00080	COG0346	lactoylglutathione lyase activity
I3J23_00090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J23_00100	COG2723	6-phospho-beta-galactosidase activity
I3J23_00105	COG2188	Transcriptional regulator
I3J23_00110	COG0793	Belongs to the peptidase S41A family
I3J23_00110	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_00115	COG2226	methyltransferase
I3J23_00125	COG1876	peptidase activity
I3J23_00145	COG0671	phosphoesterase, PA-phosphatase related
I3J23_00180	COG1509	lysine 2,3-aminomutase activity
I3J23_00185	COG0456	acetyltransferase
I3J23_00190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J23_00195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I3J23_00200	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I3J23_00205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J23_00210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I3J23_00220	COG0456	acetyltransferase
I3J23_00225	COG0463	Glycosyl transferase, family 2
I3J23_00240	COG4641	Protein conserved in bacteria
I3J23_00250	COG1086	Polysaccharide biosynthesis protein
I3J23_00290	COG1388	LysM domain
I3J23_00295	COG0457	Tetratricopeptide repeat
I3J23_00305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J23_00320	COG2197	response regulator
I3J23_00325	COG4585	Histidine kinase
I3J23_00340	COG3157	Type VI secretion system effector, Hcp
I3J23_00345	COG5444	nuclease activity
I3J23_00350	COG4282	regulation of fungal-type cell wall biogenesis
I3J23_00355	COG1525	nuclease
I3J23_00370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J23_00390	COG1846	Transcriptional regulator
I3J23_00395	COG4698	Protein conserved in bacteria
I3J23_00400	COG2755	lipolytic protein G-D-S-L family
I3J23_00405	COG1999	signal sequence binding
I3J23_00415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J23_00420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I3J23_00425	COG1272	protein, Hemolysin III
I3J23_00430	COG0204	Acyl-transferase
I3J23_00435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I3J23_00450	COG2136	Putative SAM-dependent methyltransferase
I3J23_00450	COG2521	methyltransferase
I3J23_00465	COG1413	lyase activity
I3J23_00470	COG1418	mRNA catabolic process
I3J23_00475	COG0386	Belongs to the glutathione peroxidase family
I3J23_00485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I3J23_00495	COG1278	Cold shock
I3J23_00515	COG0328	RNA-DNA hybrid ribonuclease activity
I3J23_00520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I3J23_00525	COG0328	RNA-DNA hybrid ribonuclease activity
I3J23_00535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J23_00550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I3J23_00560	COG1755	Isoprenylcysteine carboxyl methyltransferase
I3J23_00565	COG3424	synthase
I3J23_00590	COG1335	isochorismatase
I3J23_00620	COG5632	N-Acetylmuramoyl-L-alanine amidase
I3J23_00625	COG4824	toxin secretion phage lysis holin
I3J23_00645	COG5434	Belongs to the glycosyl hydrolase 28 family
I3J23_00650	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3J23_00660	COG3953	SLT domain
I3J23_00660	COG5280	Phage tail tape measure protein TP901
I3J23_00770	COG1595	DNA-templated transcription, initiation
I3J23_00810	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I3J23_00815	COG1484	DNA-dependent DNA replication
I3J23_00820	COG3935	DnaD domain protein
I3J23_00855	COG3645	SOS response
I3J23_00855	COG3646	Phage regulatory protein
I3J23_00870	COG3620	sequence-specific DNA binding
I3J23_00875	COG0582	viral genome integration into host DNA
I3J23_00880	COG2233	PERMEase
I3J23_00890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I3J23_00895	COG1199	ATP-dependent helicase activity
I3J23_00910	COG0116	Belongs to the methyltransferase superfamily
I3J23_00940	COG3359	exonuclease
I3J23_00945	COG1205	dead DEAH box helicase
I3J23_00945	COG1111	helicase
I3J23_00950	COG2190	(PTS) system
I3J23_00955	COG0071	Belongs to the small heat shock protein (HSP20) family
I3J23_00995	COG4499	WXG100 protein secretion system (Wss), protein YukC
I3J23_00995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J23_01005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I3J23_01010	COG3935	DnaD domain protein
I3J23_01020	COG0436	Aminotransferase
I3J23_01025	COG5353	protein conserved in bacteria
I3J23_01035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I3J23_01035	COG1199	ATP-dependent helicase activity
I3J23_01065	COG0438	transferase activity, transferring glycosyl groups
I3J23_01070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J23_01085	COG1694	Mazg nucleotide pyrophosphohydrolase
I3J23_01090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_01095	COG2140	Oxalate decarboxylase
I3J23_01105	COG4347	Protein of unknown function (DUF1405)
I3J23_01110	COG2010	Cytochrome c
I3J23_01110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J23_01115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I3J23_01120	COG0723	plastoquinol--plastocyanin reductase activity
I3J23_01135	COG0457	Tetratricopeptide repeat
I3J23_01145	COG0287	Prephenate dehydrogenase
I3J23_01180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J23_01185	COG4401	Chorismate mutase type I
I3J23_01200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I3J23_01205	COG0105	UTP biosynthetic process
I3J23_01210	COG0142	geranyltranstransferase activity
I3J23_01220	COG0142	geranyltranstransferase activity
I3J23_01235	COG0776	regulation of translation
I3J23_01240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I3J23_01280	COG0539	negative regulation of cytoplasmic translation
I3J23_01295	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I3J23_01300	COG2959	enzyme of heme biosynthesis
I3J23_01305	COG3773	Cell wall hydrolase
I3J23_01305	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_01310	COG2339	peptidase activity
I3J23_01315	COG0492	ferredoxin-NADP+ reductase activity
I3J23_01320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J23_01325	COG4862	establishment of competence for transformation
I3J23_01330	COG1408	metallophosphoesterase
I3J23_01340	COG1388	LysM domain
I3J23_01345	COG1266	CAAX protease self-immunity
I3J23_01350	COG0514	ATP-dependent DNA helicase (RecQ)
I3J23_01355	COG4955	Helix-turn-helix domain
I3J23_01360	COG1141	Ferredoxin
I3J23_01365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I3J23_01370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J23_01380	COG1595	DNA-templated transcription, initiation
I3J23_01385	COG5002	protein histidine kinase activity
I3J23_01390	COG0745	RESPONSE REGULATOR receiver
I3J23_01395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J23_01400	COG1333	cytochrome c biogenesis protein
I3J23_01405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_01410	COG1187	pseudouridine synthase activity
I3J23_01415	COG0700	Nucleoside recognition
I3J23_01420	COG2715	membrane protein required for spore maturation
I3J23_01425	COG1686	Belongs to the peptidase S11 family
I3J23_01450	COG1547	Domain of unknown function (DUF309)
I3J23_01455	COG0456	acetyltransferase
I3J23_01470	COG0307	riboflavin synthase, alpha
I3J23_01475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3J23_01475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I3J23_01485	COG0681	Belongs to the peptidase S26 family
I3J23_01495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I3J23_01500	COG4086	secreted protein
I3J23_01505	COG0019	diaminopimelate decarboxylase activity
I3J23_01510	COG0697	spore germination
I3J23_01525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J23_01545	COG1191	sigma factor activity
I3J23_01555	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_01560	COG1686	Belongs to the peptidase S11 family
I3J23_01565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I3J23_01570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I3J23_01575	COG4974	Belongs to the 'phage' integrase family
I3J23_01585	COG0735	belongs to the Fur family
I3J23_01590	COG1300	Membrane
I3J23_01605	COG0281	malic enzyme
I3J23_01610	COG1757	Na H antiporter
I3J23_01615	COG1027	Aspartate ammonia-lyase
I3J23_01620	COG0252	asparaginase activity
I3J23_01625	COG1396	sequence-specific DNA binding
I3J23_01630	COG1379	DNA repair
I3J23_01635	COG0494	nUDIX hydrolase
I3J23_01645	COG0667	Aldo Keto reductase
I3J23_01655	COG1073	alpha beta
I3J23_01665	COG4918	Iron-sulphur cluster biosynthesis
I3J23_01670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I3J23_01670	COG0456	acetyltransferase
I3J23_01675	COG2329	Antibiotic biosynthesis monooxygenase
I3J23_01680	COG0456	acetyltransferase
I3J23_01685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3J23_01700	COG0628	permease
I3J23_01710	COG0346	lactoylglutathione lyase activity
I3J23_01720	COG3048	D-serine ammonia-lyase activity
I3J23_01725	COG0300	oxidoreductase activity
I3J23_01730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_01735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J23_01740	COG1024	Enoyl-CoA hydratase
I3J23_01745	COG3425	synthase
I3J23_01750	COG2124	cytochrome p450
I3J23_01755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_01755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01755	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01755	COG3321	synthase
I3J23_01755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_01760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_01760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_01760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01760	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01760	COG3321	synthase
I3J23_01765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01765	COG0300	oxidoreductase activity
I3J23_01765	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_01765	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01765	COG3321	synthase
I3J23_01770	COG0300	oxidoreductase activity
I3J23_01770	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_01770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01770	COG3321	synthase
I3J23_01770	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_01775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_01775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01775	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01775	COG3321	synthase
I3J23_01780	COG0300	oxidoreductase activity
I3J23_01780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01780	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01780	COG3321	synthase
I3J23_01780	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_01785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_01785	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01785	COG3321	synthase
I3J23_01785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_01790	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_01795	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_01810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I3J23_01810	COG2070	2-Nitropropane dioxygenase
I3J23_01815	COG0250	Participates in transcription elongation, termination and antitermination
I3J23_01835	COG0596	Alpha beta hydrolase
I3J23_01850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I3J23_01855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3J23_01870	COG0706	membrane insertase activity
I3J23_01875	COG2195	Cleaves the N-terminal amino acid of tripeptides
I3J23_01880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J23_01885	COG0346	lactoylglutathione lyase activity
I3J23_01895	COG1376	ErfK ybiS ycfS ynhG family protein
I3J23_01900	COG4129	membrane
I3J23_01905	COG1126	abc transporter atp-binding protein
I3J23_01910	COG0765	amino acid transport
I3J23_01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_01925	COG1597	lipid kinase activity
I3J23_01930	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J23_01935	COG0022	dehydrogenase e1 component
I3J23_01940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I3J23_01945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J23_01950	COG3426	butyrate kinase activity
I3J23_01955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J23_01960	COG0280	phosphate acetyltransferase
I3J23_01965	COG3829	transcription factor binding
I3J23_01965	COG3290	protein histidine kinase activity
I3J23_01975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I3J23_01980	COG2079	MmgE PrpD family protein
I3J23_01985	COG0372	Belongs to the citrate synthase family
I3J23_01990	COG1960	acyl-CoA dehydrogenase activity
I3J23_01995	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J23_02000	COG0183	Belongs to the thiolase family
I3J23_02005	COG0584	glycerophosphoryl diester phosphodiesterase
I3J23_02010	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_02035	COG1902	pentaerythritol trinitrate reductase activity
I3J23_02050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J23_02055	COG0745	RESPONSE REGULATOR receiver
I3J23_02060	COG0750	zinc metalloprotease
I3J23_02065	COG0497	DNA recombination
I3J23_02075	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I3J23_02085	COG0142	geranyltranstransferase activity
I3J23_02095	COG1570	exodeoxyribonuclease VII activity
I3J23_02110	COG1302	Protein conserved in bacteria
I3J23_02115	COG0439	Biotin carboxylase
I3J23_02120	COG0511	ligase activity, forming carbon-carbon bonds
I3J23_02160	COG3854	ATPases associated with a variety of cellular activities
I3J23_02175	COG0006	proline dipeptidase activity
I3J23_02185	COG3872	metal-dependent enzyme
I3J23_02195	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3J23_02210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J23_02230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J23_02245	COG1396	sequence-specific DNA binding
I3J23_02255	COG0681	Belongs to the peptidase S26 family
I3J23_02280	COG4940	Competence protein ComGF
I3J23_02290	COG4970	Tfp pilus assembly protein FimT
I3J23_02295	COG4537	Required for transformation and DNA binding
I3J23_02300	COG1459	type II secretion system
I3J23_02305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I3J23_02310	COG0598	Magnesium transport protein CorA
I3J23_02315	COG1253	flavin adenine dinucleotide binding
I3J23_02320	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_02330	COG1393	Belongs to the ArsC family
I3J23_02340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_02350	COG0011	TIGRFAM Protein of
I3J23_02360	COG2866	Carboxypeptidase
I3J23_02365	COG1940	carbohydrate kinase activity
I3J23_02370	COG4483	Protein conserved in bacteria
I3J23_02375	COG1757	Na H antiporter
I3J23_02385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I3J23_02400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J23_02405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3J23_02410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3J23_02415	COG0581	inorganic phosphate transmembrane transporter activity
I3J23_02420	COG0573	inorganic phosphate transmembrane transporter activity
I3J23_02425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I3J23_02430	COG0768	penicillin binding
I3J23_02435	COG0477	Major facilitator Superfamily
I3J23_02440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J23_02445	COG2839	Protein conserved in bacteria
I3J23_02450	COG5521	maltodextrose utilization protein MalA
I3J23_02455	COG1388	LysM domain
I3J23_02465	COG4709	membrane
I3J23_02470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I3J23_02475	COG0735	belongs to the Fur family
I3J23_02480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_02495	COG0513	Belongs to the DEAD box helicase family
I3J23_02510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3J23_02515	COG2384	SAM-dependent methyltransferase
I3J23_02520	COG2010	Cytochrome c
I3J23_02525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3J23_02530	COG0358	DNA primase activity
I3J23_02545	COG0517	IMP dehydrogenase activity
I3J23_02550	COG0751	glycine-tRNA ligase activity
I3J23_02570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I3J23_02575	COG0295	cytidine deaminase activity
I3J23_02580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I3J23_02590	COG1480	7TM receptor with intracellular HD hydrolase
I3J23_02595	COG1702	phosphate starvation-inducible protein PhoH
I3J23_02600	COG0561	phosphatase activity
I3J23_02615	COG4864	UPF0365 protein
I3J23_02620	COG1030	water channel activity
I3J23_02625	COG1610	YqeY-like protein
I3J23_02635	COG1283	sodium-dependent phosphate transmembrane transporter activity
I3J23_02640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I3J23_02645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3J23_02675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J23_02690	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_02705	COG1466	dna polymerase III delta subunit
I3J23_02720	COG0658	competence protein
I3J23_02720	COG2333	competence protein COMEC
I3J23_02725	COG2131	deaminase
I3J23_02730	COG1555	photosystem II stabilization
I3J23_02730	COG1596	polysaccharide export
I3J23_02735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3J23_02740	COG2226	methyltransferase
I3J23_02745	COG0799	negative regulation of ribosome biogenesis
I3J23_02750	COG1713	HD superfamily hydrolase involved in NAD metabolism
I3J23_02760	COG1534	Rna-binding protein
I3J23_02765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3J23_02770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I3J23_02775	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I3J23_02785	COG2755	lipolytic protein G-D-S-L family
I3J23_02795	COG0398	Pfam SNARE associated Golgi protein
I3J23_02820	COG2207	Transcriptional regulator
I3J23_02820	COG3708	Transcriptional regulator
I3J23_02825	COG0563	adenylate kinase activity
I3J23_02830	COG2814	Major facilitator Superfamily
I3J23_02850	COG5444	nuclease activity
I3J23_02890	COG0456	acetyltransferase
I3J23_02895	COG2318	DinB family
I3J23_02905	COG0561	phosphatase activity
I3J23_02920	COG1482	cell wall glycoprotein biosynthetic process
I3J23_02925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3J23_02925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3J23_02925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_02930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_02930	COG3711	transcriptional antiterminator
I3J23_02940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3J23_02945	COG0583	DNA-binding transcription factor activity
I3J23_02950	COG2814	Major facilitator Superfamily
I3J23_02955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3J23_02955	COG2124	cytochrome p450
I3J23_02960	COG1309	transcriptional regulator
I3J23_02965	COG2226	methyltransferase
I3J23_02980	COG2116	formate transmembrane transporter activity
I3J23_02985	COG5609	conserved protein (DUF2294)
I3J23_02990	COG3383	formate dehydrogenase (NAD+) activity
I3J23_02995	COG2427	Protein of unknown function (DUF1641)
I3J23_03005	COG0626	cystathionine gamma-synthase activity
I3J23_03010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J23_03035	COG0768	penicillin binding
I3J23_03050	COG0826	peptidase U32
I3J23_03055	COG0826	peptidase U32
I3J23_03060	COG4122	O-methyltransferase activity
I3J23_03065	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I3J23_03080	COG4472	Bacterial protein of unknown function (DUF965)
I3J23_03090	COG0628	permease
I3J23_03095	COG1126	abc transporter atp-binding protein
I3J23_03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_03105	COG0765	amino acid transport
I3J23_03110	COG0765	amino acid transport
I3J23_03125	COG3881	PFAM PRC-barrel domain
I3J23_03130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3J23_03135	COG0457	Tetratricopeptide repeat
I3J23_03145	COG1104	cysteine desulfurase activity
I3J23_03150	COG1959	2 iron, 2 sulfur cluster binding
I3J23_03155	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3J23_03160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I3J23_03185	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_03185	COG3103	Sh3 type 3 domain protein
I3J23_03185	COG4991	sh3 domain protein
I3J23_03195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3J23_03205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I3J23_03205	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I3J23_03210	COG5416	Lipopolysaccharide assembly protein A domain
I3J23_03215	COG0490	domain, Protein
I3J23_03220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J23_03220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I3J23_03230	COG2244	polysaccharide biosynthetic process
I3J23_03235	COG2323	membrane
I3J23_03245	COG1862	Preprotein translocase
I3J23_03290	COG1388	LysM domain
I3J23_03300	COG0157	Belongs to the NadC ModD family
I3J23_03305	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3J23_03310	COG1104	cysteine desulfurase activity
I3J23_03315	COG1827	regulation of RNA biosynthetic process
I3J23_03320	COG0077	Prephenate dehydratase
I3J23_03335	COG3290	protein histidine kinase activity
I3J23_03340	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I3J23_03345	COG2868	ribosomal protein
I3J23_03355	COG1994	Peptidase M50
I3J23_03360	COG0739	heme binding
I3J23_03365	COG2894	cell division
I3J23_03375	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I3J23_03385	COG1077	Cell shape determining protein MreB Mrl
I3J23_03405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I3J23_03410	COG0285	dihydrofolate synthase activity
I3J23_03415	COG0525	valine-tRNA ligase activity
I3J23_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J23_03430	COG1388	LysM domain
I3J23_03440	COG0113	porphobilinogen synthase activity
I3J23_03445	COG1587	Uroporphyrinogen-III synthase
I3J23_03455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I3J23_03475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I3J23_03480	COG0470	DNA polymerase III
I3J23_03480	COG1067	ATP-dependent peptidase activity
I3J23_03495	COG0457	Tetratricopeptide repeat
I3J23_03495	COG1477	protein flavinylation
I3J23_03510	COG0473	3-isopropylmalate dehydrogenase activity
I3J23_03525	COG0440	acetolactate synthase activity
I3J23_03530	COG0028	Belongs to the TPP enzyme family
I3J23_03560	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I3J23_03580	COG0622	Phosphoesterase
I3J23_03585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I3J23_03595	COG5401	PFAM Sporulation and spore germination
I3J23_03605	COG1846	Transcriptional regulator
I3J23_03610	COG2197	response regulator
I3J23_03615	COG0824	Thioesterase
I3J23_03620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I3J23_03625	COG1053	succinate dehydrogenase
I3J23_03630	COG2009	succinate dehydrogenase
I3J23_03635	COG1719	4-vinyl reductase, 4VR
I3J23_03640	COG0527	aspartate kinase activity
I3J23_03650	COG3118	belongs to the thioredoxin family
I3J23_03655	COG3534	alpha-L-arabinofuranosidase
I3J23_03660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I3J23_03665	COG2086	electron transfer activity
I3J23_03670	COG1024	Enoyl-CoA hydratase
I3J23_03675	COG1309	transcriptional regulator
I3J23_03680	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_03690	COG3766	membrane
I3J23_03700	COG1796	DNA polymerase
I3J23_03700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J23_03705	COG1286	toxin biosynthetic process
I3J23_03720	COG0072	phenylalanine-tRNA ligase activity
I3J23_03720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J23_03725	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I3J23_03730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J23_03740	COG3835	regulator
I3J23_03745	COG0277	FAD linked oxidase domain protein
I3J23_03750	COG0247	lactate metabolic process
I3J23_03755	COG1966	Carbon starvation protein
I3J23_03760	COG3534	alpha-L-arabinofuranosidase
I3J23_03765	COG0395	ABC-type sugar transport system, permease component
I3J23_03770	COG1175	transmembrane transport
I3J23_03775	COG1653	transport
I3J23_03785	COG0647	UMP catabolic process
I3J23_03790	COG0235	Class ii aldolase
I3J23_03795	COG1069	ribulokinase activity
I3J23_03800	COG2160	L-arabinose isomerase activity
I3J23_03805	COG3507	Belongs to the glycosyl hydrolase 43 family
I3J23_03810	COG1363	Peptidase, m42
I3J23_03820	COG3326	Membrane
I3J23_03825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I3J23_03835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3J23_03840	COG1346	cytolysis
I3J23_03845	COG1380	Effector of murein hydrolase LrgA
I3J23_03850	COG3279	Response regulator of the LytR AlgR family
I3J23_03855	COG3275	phosphorelay sensor kinase activity
I3J23_03860	COG1011	Hydrolase
I3J23_03875	COG0398	Pfam SNARE associated Golgi protein
I3J23_03880	COG1484	DNA-dependent DNA replication
I3J23_03885	COG3611	Membrane attachment protein
I3J23_03900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J23_03905	COG1733	regulation of RNA biosynthetic process
I3J23_03910	COG2814	Major facilitator Superfamily
I3J23_03915	COG0656	L-ascorbic acid biosynthetic process
I3J23_03920	COG0237	dephospho-CoA kinase activity
I3J23_03925	COG1971	Probably functions as a manganese efflux pump
I3J23_03930	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I3J23_03935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J23_03935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I3J23_03940	COG5002	protein histidine kinase activity
I3J23_03945	COG0745	RESPONSE REGULATOR receiver
I3J23_03955	COG0538	isocitrate dehydrogenase activity
I3J23_03960	COG0372	Belongs to the citrate synthase family
I3J23_03980	COG0628	permease
I3J23_03985	COG3030	protein affecting phage T7 exclusion by the F plasmid
I3J23_03990	COG0469	pyruvate kinase activity
I3J23_04010	COG0281	malic enzyme
I3J23_04015	COG0587	DNA-directed DNA polymerase activity
I3J23_04035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I3J23_04045	COG4109	DRTGG domain
I3J23_04055	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_04070	COG0521	Mo-molybdopterin cofactor biosynthetic process
I3J23_04080	COG0827	DNA restriction-modification system
I3J23_04085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I3J23_04090	COG3874	Sporulation protein YtfJ
I3J23_04100	COG1714	RDD family
I3J23_04105	COG0616	signal peptide processing
I3J23_04110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J23_04115	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I3J23_04120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J23_04135	COG1104	cysteine desulfurase activity
I3J23_04140	COG1114	Component of the transport system for branched-chain amino acids
I3J23_04150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I3J23_04155	COG1309	transcriptional regulator
I3J23_04160	COG1956	GAF domain-containing protein
I3J23_04165	COG2199	diguanylate cyclase activity
I3J23_04165	COG2203	Gaf domain
I3J23_04175	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_04180	COG4282	regulation of fungal-type cell wall biogenesis
I3J23_04185	COG1017	nitric oxide dioxygenase activity
I3J23_04185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J23_04195	COG0693	protein deglycase activity
I3J23_04210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I3J23_04215	COG1378	Sugar-specific transcriptional regulator TrmB
I3J23_04235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I3J23_04240	COG0454	-acetyltransferase
I3J23_04245	COG0517	IMP dehydrogenase activity
I3J23_04250	COG0123	including yeast histone deacetylase and acetoin utilization protein
I3J23_04255	COG1360	Flagellar Motor Protein
I3J23_04260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3J23_04265	COG1609	Transcriptional regulator
I3J23_04270	COG1605	Chorismate mutase
I3J23_04270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I3J23_04275	COG3118	belongs to the thioredoxin family
I3J23_04280	COG4980	gas vesicle protein
I3J23_04285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I3J23_04295	COG1674	ftsk spoiiie
I3J23_04300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J23_04310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_04320	COG1363	Peptidase, m42
I3J23_04325	COG5584	Small secreted protein
I3J23_04330	COG0281	malic enzyme
I3J23_04335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_04350	COG0510	thiamine kinase activity
I3J23_04355	COG1597	lipid kinase activity
I3J23_04365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I3J23_04370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J23_04375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J23_04380	COG2252	PERMEase
I3J23_04385	COG4473	ABC transporter
I3J23_04390	COG1131	(ABC) transporter
I3J23_04395	COG1349	DNA-binding transcription factor activity
I3J23_04400	COG1187	pseudouridine synthase activity
I3J23_04405	COG2244	polysaccharide biosynthetic process
I3J23_04410	COG2081	HI0933 family
I3J23_04415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J23_04425	COG1609	Transcriptional regulator
I3J23_04430	COG1653	transport
I3J23_04435	COG1175	transmembrane transport
I3J23_04440	COG0395	ABC-type sugar transport system, permease component
I3J23_04445	COG1486	melibiose metabolic process
I3J23_04455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J23_04470	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_04470	COG2202	Pas domain
I3J23_04475	COG2814	Major facilitator Superfamily
I3J23_04480	COG5522	Integral membrane protein (intg_mem_TP0381)
I3J23_04485	COG0577	efflux transmembrane transporter activity
I3J23_04490	COG1136	(ABC) transporter
I3J23_04495	COG2205	protein histidine kinase activity
I3J23_04500	COG0745	RESPONSE REGULATOR receiver
I3J23_04505	COG0577	efflux transmembrane transporter activity
I3J23_04510	COG1136	(ABC) transporter
I3J23_04530	COG1131	(ABC) transporter
I3J23_04535	COG1725	Transcriptional regulator
I3J23_04545	COG1242	4 iron, 4 sulfur cluster binding
I3J23_04550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I3J23_04560	COG0584	glycerophosphoryl diester phosphodiesterase
I3J23_04570	COG2267	carboxylic ester hydrolase activity
I3J23_04575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I3J23_04580	COG1113	amino acid transport
I3J23_04585	COG0367	asparagine synthase
I3J23_04605	COG1506	peptidase
I3J23_04610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3J23_04615	COG1116	anion transmembrane transporter activity
I3J23_04620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J23_04625	COG0494	nUDIX hydrolase
I3J23_04630	COG4824	toxin secretion phage lysis holin
I3J23_04635	COG0783	Belongs to the Dps family
I3J23_04660	COG0288	reversible hydration of carbon dioxide
I3J23_04670	COG1271	oxidase subunit
I3J23_04675	COG1294	oxidase, subunit
I3J23_04685	COG4948	Mandelate Racemase Muconate Lactonizing
I3J23_04695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I3J23_04700	COG0596	Alpha beta hydrolase
I3J23_04710	COG1169	isochorismate synthase
I3J23_04715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3J23_04720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I3J23_04845	COG3859	Proton-coupled thiamine transporter YuaJ
I3J23_04850	COG2268	Band 7 protein
I3J23_04855	COG1585	Membrane protein implicated in regulation of membrane protease activity
I3J23_04860	COG2318	DinB family
I3J23_04870	COG1454	alcohol dehydrogenase
I3J23_04875	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_04880	COG1510	regulation of RNA biosynthetic process
I3J23_04890	COG0569	domain protein
I3J23_04895	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3J23_04900	COG1017	nitric oxide dioxygenase activity
I3J23_04900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I3J23_04940	COG0628	permease
I3J23_04945	COG0673	inositol 2-dehydrogenase activity
I3J23_04950	COG0693	protein deglycase activity
I3J23_04955	COG0840	transmembrane signaling receptor activity
I3J23_04960	COG0840	transmembrane signaling receptor activity
I3J23_04965	COG0840	transmembrane signaling receptor activity
I3J23_04970	COG0840	transmembrane signaling receptor activity
I3J23_04985	COG2070	2-Nitropropane dioxygenase
I3J23_04990	COG0432	Pfam Uncharacterised protein family UPF0047
I3J23_04995	COG0366	Alpha amylase catalytic
I3J23_05000	COG1253	flavin adenine dinucleotide binding
I3J23_05005	COG2738	Putative neutral zinc metallopeptidase
I3J23_05020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I3J23_05045	COG1335	isochorismatase
I3J23_05050	COG1979	alcohol dehydrogenase
I3J23_05055	COG1979	alcohol dehydrogenase
I3J23_05060	COG2155	Conserved Protein
I3J23_05065	COG1098	S1 RNA binding domain
I3J23_05070	COG0436	Aminotransferase
I3J23_05075	COG1522	sequence-specific DNA binding
I3J23_05080	COG2267	carboxylic ester hydrolase activity
I3J23_05090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3J23_05095	COG2205	protein histidine kinase activity
I3J23_05105	COG5018	Exonuclease
I3J23_05110	COG2814	Major facilitator Superfamily
I3J23_05115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J23_05120	COG3011	Protein conserved in bacteria
I3J23_05130	COG3290	protein histidine kinase activity
I3J23_05135	COG4565	transcriptional regulatory protein
I3J23_05140	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J23_05145	COG3845	ABC transporter
I3J23_05150	COG4603	Belongs to the binding-protein-dependent transport system permease family
I3J23_05155	COG1079	Belongs to the binding-protein-dependent transport system permease family
I3J23_05165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I3J23_05165	COG2111	Na H antiporter
I3J23_05170	COG2111	Na H antiporter
I3J23_05175	COG1006	Multisubunit Na H antiporter MnhC subunit
I3J23_05180	COG0651	ATP synthesis coupled electron transport
I3J23_05185	COG1863	multisubunit Na H antiporter MnhE subunit
I3J23_05190	COG2212	antiporter activity
I3J23_05195	COG1320	monovalent cation:proton antiporter activity
I3J23_05200	COG2050	protein possibly involved in aromatic compounds catabolism
I3J23_05205	COG2197	response regulator
I3J23_05210	COG4585	Histidine kinase
I3J23_05220	COG0142	geranyltranstransferase activity
I3J23_05240	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I3J23_05245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I3J23_05250	COG1335	isochorismatase
I3J23_05255	COG5506	Protein of unknown function (DUF1694)
I3J23_05270	COG0628	permease
I3J23_05280	COG1418	mRNA catabolic process
I3J23_05285	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_05295	COG1511	domain protein
I3J23_05300	COG0433	COG0433 Predicted ATPase
I3J23_05300	COG1674	ftsk spoiiie
I3J23_05305	COG4499	WXG100 protein secretion system (Wss), protein YukC
I3J23_05310	COG5417	Belongs to the EsaB family
I3J23_05315	COG4842	Belongs to the WXG100 family
I3J23_05320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I3J23_05320	COG2508	Transcriptional regulator
I3J23_05325	COG0686	Belongs to the AlaDH PNT family
I3J23_05330	COG5634	Uncharacterized conserved protein (DUF2278)
I3J23_05335	COG3251	PFAM MbtH domain protein
I3J23_05340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_05345	COG3433	isochorismatase activity
I3J23_05345	COG1535	isochorismatase
I3J23_05350	COG1021	2,3-dihydroxybenzoate-AMP ligase
I3J23_05355	COG1169	isochorismate synthase
I3J23_05360	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_05365	COG2819	hydrolase of the alpha beta superfamily
I3J23_05370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J23_05375	COG1268	BioY protein
I3J23_05380	COG2056	Na+-H+ antiporter family
I3J23_05390	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I3J23_05395	COG3584	3D domain protein
I3J23_05410	COG1252	NADH dehydrogenase
I3J23_05440	COG1131	(ABC) transporter
I3J23_05465	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I3J23_05470	COG0316	Belongs to the HesB IscA family
I3J23_05480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3J23_05490	COG1252	NADH dehydrogenase
I3J23_05495	COG4837	Protein of unknown function (DUF1462)
I3J23_05500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I3J23_05505	COG0823	Involved in the tonB-independent uptake of proteins
I3J23_05505	COG1506	peptidase
I3J23_05505	COG4946	Tricorn protease homolog
I3J23_05515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I3J23_05520	COG0460	homoserine dehydrogenase
I3J23_05525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J23_05530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I3J23_05535	COG0647	UMP catabolic process
I3J23_05540	COG2445	Protein of unknown function DUF86
I3J23_05545	COG4470	Protein conserved in bacteria
I3J23_05555	COG0739	heme binding
I3J23_05565	COG0737	Belongs to the 5'-nucleotidase family
I3J23_05570	COG0730	response to heat
I3J23_05575	COG1801	Protein of unknown function DUF72
I3J23_05590	COG2508	Transcriptional regulator
I3J23_05605	COG2814	Major facilitator Superfamily
I3J23_05610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I3J23_05615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J23_05620	COG2356	endonuclease I
I3J23_05625	COG3842	ATPase activity
I3J23_05630	COG2188	Transcriptional regulator
I3J23_05635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J23_05640	COG0395	ABC-type sugar transport system, permease component
I3J23_05645	COG1175	transmembrane transport
I3J23_05650	COG1653	transport
I3J23_05655	COG2222	sugar isomerase
I3J23_05660	COG0789	Transcriptional regulator
I3J23_05675	COG0322	excinuclease ABC activity
I3J23_05680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J23_05685	COG2226	methyltransferase
I3J23_05695	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_05700	COG0719	Fe-S assembly protein
I3J23_05705	COG0822	iron-sulfur transferase activity
I3J23_05710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J23_05715	COG0719	Fe-S assembly protein
I3J23_05720	COG0396	ATPase activity
I3J23_05730	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J23_05735	COG1464	Belongs to the NlpA lipoprotein family
I3J23_05740	COG2011	ABC-type metal ion transport system permease component
I3J23_05745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I3J23_05755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_05760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I3J23_05775	COG1393	Belongs to the ArsC family
I3J23_05780	COG1960	acyl-CoA dehydrogenase activity
I3J23_05785	COG0183	Belongs to the thiolase family
I3J23_05790	COG1024	Enoyl-CoA hydratase
I3J23_05790	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3J23_05810	COG5577	PFAM Coat F domain
I3J23_05815	COG1846	Transcriptional regulator
I3J23_05820	COG0477	Major facilitator Superfamily
I3J23_05825	COG0583	DNA-binding transcription factor activity
I3J23_05845	COG1120	ATPase activity
I3J23_05860	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_05865	COG0783	Belongs to the Dps family
I3J23_05870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J23_05875	COG0745	RESPONSE REGULATOR receiver
I3J23_05880	COG2205	protein histidine kinase activity
I3J23_05880	COG2770	Histidine kinase
I3J23_05890	COG1309	transcriptional regulator
I3J23_05895	COG0114	fumarate hydratase activity
I3J23_05905	COG0697	spore germination
I3J23_05910	COG0814	amino acid
I3J23_05920	COG2197	response regulator
I3J23_05925	COG4585	Histidine kinase
I3J23_05930	COG4758	membrane
I3J23_05935	COG3595	metallopeptidase activity
I3J23_05940	COG1842	Phage shock protein A
I3J23_05945	COG4758	membrane
I3J23_05950	COG2814	Major facilitator Superfamily
I3J23_05955	COG2096	Adenosyltransferase
I3J23_05960	COG1120	ATPase activity
I3J23_05965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_05970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J23_05975	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_05980	COG3386	PFAM SMP-30 Gluconolaconase
I3J23_05985	COG2205	protein histidine kinase activity
I3J23_05990	COG0745	RESPONSE REGULATOR receiver
I3J23_06000	COG1191	sigma factor activity
I3J23_06010	COG2140	Oxalate decarboxylase
I3J23_06020	COG1120	ATPase activity
I3J23_06025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_06030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_06035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J23_06040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I3J23_06045	COG0531	amino acid
I3J23_06055	COG1988	membrane-bound metal-dependent
I3J23_06060	COG1368	sulfuric ester hydrolase activity
I3J23_06065	COG1910	domain protein
I3J23_06070	COG0725	ABC transporter, periplasmic molybdate-binding protein
I3J23_06075	COG4149	molybdate abc transporter
I3J23_06080	COG2197	response regulator
I3J23_06085	COG3850	Histidine kinase
I3J23_06090	COG1131	(ABC) transporter
I3J23_06100	COG0842	Transport permease protein
I3J23_06105	COG0656	L-ascorbic acid biosynthetic process
I3J23_06125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3J23_06130	COG3973	AAA domain
I3J23_06135	COG2860	membrane
I3J23_06145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I3J23_06150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I3J23_06155	COG2217	Heavy metal translocating P-type atpase
I3J23_06160	COG2217	Heavy metal translocating P-type atpase
I3J23_06165	COG2608	mercury ion transmembrane transporter activity
I3J23_06170	COG1937	Protein conserved in bacteria
I3J23_06175	COG0673	inositol 2-dehydrogenase activity
I3J23_06190	COG2814	Major facilitator Superfamily
I3J23_06205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_06210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I3J23_06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_06220	COG1126	abc transporter atp-binding protein
I3J23_06225	COG0765	amino acid transport
I3J23_06230	COG0765	amino acid transport
I3J23_06235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_06240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_06245	COG0454	-acetyltransferase
I3J23_06250	COG0583	DNA-binding transcription factor activity
I3J23_06255	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_06260	COG2732	(Barnase) inhibitor
I3J23_06275	COG0557	exoribonuclease II activity
I3J23_06280	COG1647	Serine aminopeptidase, S33
I3J23_06285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J23_06290	COG1476	TRANSCRIPTIONal
I3J23_06295	COG1396	sequence-specific DNA binding
I3J23_06300	COG1396	sequence-specific DNA binding
I3J23_06305	COG1733	regulation of RNA biosynthetic process
I3J23_06330	COG1131	(ABC) transporter
I3J23_06335	COG1174	glycine betaine transport
I3J23_06340	COG1732	Glycine betaine
I3J23_06345	COG1174	glycine betaine transport
I3J23_06350	COG0517	IMP dehydrogenase activity
I3J23_06350	COG1125	glycine betaine transport
I3J23_06355	COG1510	regulation of RNA biosynthetic process
I3J23_06360	COG1174	glycine betaine transport
I3J23_06365	COG1732	Glycine betaine
I3J23_06370	COG1174	glycine betaine transport
I3J23_06375	COG0517	IMP dehydrogenase activity
I3J23_06375	COG1125	glycine betaine transport
I3J23_06380	COG1510	regulation of RNA biosynthetic process
I3J23_06385	COG2095	MarC family integral membrane protein
I3J23_06390	COG3064	Membrane
I3J23_06395	COG4640	response to antibiotic
I3J23_06400	COG0456	acetyltransferase
I3J23_06415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I3J23_06430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3J23_06435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_06440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3J23_06450	COG2234	aminopeptidase activity
I3J23_06470	COG0126	phosphoglycerate kinase activity
I3J23_06475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I3J23_06480	COG2390	Transcriptional regulator
I3J23_06485	COG2814	Major facilitator Superfamily
I3J23_06490	COG1609	Transcriptional regulator
I3J23_06495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_06505	COG0583	DNA-binding transcription factor activity
I3J23_06510	COG0697	spore germination
I3J23_06515	COG1113	amino acid transport
I3J23_06520	COG1737	Transcriptional regulator
I3J23_06525	COG1070	Carbohydrate kinase
I3J23_06550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J23_06555	COG2186	Transcriptional regulator
I3J23_06560	COG1620	l-lactate permease
I3J23_06565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I3J23_06575	COG5039	Polysaccharide pyruvyl transferase
I3J23_06580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3J23_06585	COG0110	maltose O-acetyltransferase activity
I3J23_06590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I3J23_06595	COG2244	polysaccharide biosynthetic process
I3J23_06600	COG1216	Glycosyl transferase, family 2
I3J23_06605	COG5039	Polysaccharide pyruvyl transferase
I3J23_06610	COG1216	Glycosyl transferase, family 2
I3J23_06620	COG0438	transferase activity, transferring glycosyl groups
I3J23_06625	COG1215	transferase activity, transferring glycosyl groups
I3J23_06630	COG0438	transferase activity, transferring glycosyl groups
I3J23_06635	COG1086	Polysaccharide biosynthesis protein
I3J23_06640	COG0489	protein tyrosine kinase activity
I3J23_06645	COG3944	biosynthesis protein
I3J23_06650	COG1396	sequence-specific DNA binding
I3J23_06655	COG2272	Belongs to the type-B carboxylesterase lipase family
I3J23_06665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I3J23_06670	COG2364	Membrane
I3J23_06675	COG0456	acetyltransferase
I3J23_06680	COG3479	Phenolic acid decarboxylase
I3J23_06740	COG2223	nitrite transmembrane transporter activity
I3J23_06745	COG1609	Transcriptional regulator
I3J23_06755	COG0583	DNA-binding transcription factor activity
I3J23_06760	COG2828	Protein conserved in bacteria
I3J23_06765	COG0477	Major facilitator Superfamily
I3J23_06765	COG2814	Major facilitator Superfamily
I3J23_06770	COG1611	Belongs to the LOG family
I3J23_06775	COG1694	Mazg nucleotide pyrophosphohydrolase
I3J23_06780	COG0659	secondary active sulfate transmembrane transporter activity
I3J23_06785	COG0288	reversible hydration of carbon dioxide
I3J23_06790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J23_06795	COG4290	ribonuclease
I3J23_06800	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I3J23_06805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_06815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I3J23_06825	COG1051	belongs to the nudix hydrolase family
I3J23_06830	COG0492	ferredoxin-NADP+ reductase activity
I3J23_06835	COG3883	PFAM NLP P60 protein
I3J23_06835	COG0791	NLP P60 protein
I3J23_06840	COG0457	Tetratricopeptide repeat
I3J23_06845	COG5002	protein histidine kinase activity
I3J23_06850	COG0745	RESPONSE REGULATOR receiver
I3J23_06860	COG1132	(ABC) transporter
I3J23_06865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I3J23_06865	COG0140	phosphoribosyl-ATP diphosphatase activity
I3J23_06890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I3J23_06905	COG4990	cell redox homeostasis
I3J23_06910	COG0110	maltose O-acetyltransferase activity
I3J23_06930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I3J23_06940	COG2188	Transcriptional regulator
I3J23_06945	COG1309	transcriptional regulator
I3J23_06950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I3J23_06955	COG1950	PFAM Membrane protein of
I3J23_06960	COG1983	PspC domain protein
I3J23_06965	COG3595	metallopeptidase activity
I3J23_06980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3J23_06990	COG4897	Protein conserved in bacteria
I3J23_06995	COG0574	Belongs to the PEP-utilizing enzyme family
I3J23_06995	COG3848	Pyruvate phosphate dikinase
I3J23_07000	COG1309	transcriptional regulator
I3J23_07005	COG2814	Major facilitator Superfamily
I3J23_07040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J23_07050	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_07050	COG0793	Belongs to the peptidase S41A family
I3J23_07055	COG3420	alginic acid biosynthetic process
I3J23_07060	COG2177	Part of the ABC transporter FtsEX involved in
I3J23_07065	COG2884	Cell division ATP-binding protein ftsE
I3J23_07070	COG2010	Cytochrome c
I3J23_07075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_07090	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3J23_07105	COG1516	flagellar protein fliS
I3J23_07110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I3J23_07115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3J23_07135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I3J23_07140	COG1256	bacterial-type flagellum assembly
I3J23_07140	COG4786	Flagellar basal body rod
I3J23_07145	COG3418	PFAM FlgN family protein
I3J23_07150	COG2747	anti-sigma28 factor FlgM
I3J23_07160	COG1040	competence protein
I3J23_07170	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I3J23_07175	COG1307	EDD domain protein, DegV family
I3J23_07180	COG2197	response regulator
I3J23_07185	COG4585	Histidine kinase
I3J23_07190	COG1739	Uncharacterized protein family UPF0029
I3J23_07195	COG1316	TRANSCRIPTIONal
I3J23_07200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3J23_07205	COG0438	transferase activity, transferring glycosyl groups
I3J23_07210	COG1215	transferase activity, transferring glycosyl groups
I3J23_07215	COG3206	protein involved in exopolysaccharide biosynthesis
I3J23_07220	COG3307	-O-antigen
I3J23_07225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J23_07230	COG0297	glycogen (starch) synthase activity
I3J23_07230	COG0438	transferase activity, transferring glycosyl groups
I3J23_07235	COG2244	polysaccharide biosynthetic process
I3J23_07245	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_07245	COG2247	cell wall binding repeat
I3J23_07250	COG2385	sporulation resulting in formation of a cellular spore
I3J23_07250	COG2247	cell wall binding repeat
I3J23_07260	COG1316	TRANSCRIPTIONal
I3J23_07265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I3J23_07270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J23_07275	COG1134	teichoic acid transport
I3J23_07280	COG1682	transport, permease protein
I3J23_07285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I3J23_07295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3J23_07300	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I3J23_07305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I3J23_07310	COG4193	domain, Protein
I3J23_07315	COG1482	cell wall glycoprotein biosynthetic process
I3J23_07320	COG0697	spore germination
I3J23_07325	COG0814	amino acid
I3J23_07335	COG1215	transferase activity, transferring glycosyl groups
I3J23_07340	COG2814	Major facilitator Superfamily
I3J23_07345	COG1316	TRANSCRIPTIONal
I3J23_07350	COG0561	phosphatase activity
I3J23_07355	COG2433	Pfam Transposase IS66
I3J23_07360	COG0791	NLP P60 protein
I3J23_07370	COG2843	Capsule synthesis protein
I3J23_07380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I3J23_07385	COG0697	spore germination
I3J23_07390	COG0814	amino acid
I3J23_07400	COG1609	Transcriptional regulator
I3J23_07405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J23_07415	COG1129	ABC transporter
I3J23_07420	COG1172	Belongs to the binding-protein-dependent transport system permease family
I3J23_07425	COG1879	ABC-type sugar transport system periplasmic component
I3J23_07430	COG3103	Sh3 type 3 domain protein
I3J23_07435	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3J23_07440	COG3527	Alpha-acetolactate decarboxylase
I3J23_07445	COG0028	Belongs to the TPP enzyme family
I3J23_07450	COG0583	DNA-binding transcription factor activity
I3J23_07455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3J23_07470	COG5337	Spore coat protein CotH
I3J23_07480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I3J23_07490	COG0405	Gamma-glutamyltransferase
I3J23_07495	COG1522	sequence-specific DNA binding
I3J23_07500	COG2059	Chromate
I3J23_07505	COG2059	Chromate
I3J23_07515	COG0655	NAD(P)H dehydrogenase (quinone) activity
I3J23_07520	COG0583	DNA-binding transcription factor activity
I3J23_07540	COG5444	nuclease activity
I3J23_07555	COG3878	Protein conserved in bacteria
I3J23_07560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I3J23_07565	COG4464	protein tyrosine phosphatase activity
I3J23_07570	COG0489	protein tyrosine kinase activity
I3J23_07575	COG3944	biosynthesis protein
I3J23_07585	COG4715	Zinc finger, swim domain protein
I3J23_07590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I3J23_07595	COG0561	phosphatase activity
I3J23_07600	COG1349	DNA-binding transcription factor activity
I3J23_07605	COG0629	single-stranded DNA binding
I3J23_07630	COG0457	Tetratricopeptide repeat
I3J23_07635	COG4786	Flagellar basal body rod
I3J23_07640	COG4786	Flagellar basal body rod
I3J23_07645	COG1077	Cell shape determining protein MreB Mrl
I3J23_07650	COG1609	Transcriptional regulator
I3J23_07655	COG1846	Transcriptional regulator
I3J23_07660	COG2814	Major facilitator Superfamily
I3J23_07665	COG1953	Uracil, thiamine, allantoin
I3J23_07670	COG0477	Major facilitator Superfamily
I3J23_07675	COG1335	isochorismatase
I3J23_07680	COG0004	ammonium transporteR
I3J23_07685	COG0347	Belongs to the P(II) protein family
I3J23_07690	COG0772	Belongs to the SEDS family
I3J23_07695	COG0671	phosphoesterase, PA-phosphatase related
I3J23_07705	COG0739	heme binding
I3J23_07710	COG1247	-acetyltransferase
I3J23_07725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3J23_07735	COG0726	polysaccharide deacetylase
I3J23_07745	COG1959	2 iron, 2 sulfur cluster binding
I3J23_07760	COG0831	urea catabolic process
I3J23_07765	COG3237	CsbD-like
I3J23_07770	COG1994	Peptidase M50
I3J23_07775	COG0457	Tetratricopeptide repeat
I3J23_07785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I3J23_07795	COG2304	oxidoreductase activity
I3J23_07800	COG2304	oxidoreductase activity
I3J23_07805	COG2385	sporulation resulting in formation of a cellular spore
I3J23_07810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J23_07820	COG4836	Membrane
I3J23_07890	COG0698	ribose 5-phosphate isomerase
I3J23_07895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J23_07905	COG0009	L-threonylcarbamoyladenylate synthase
I3J23_07910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I3J23_07930	COG2890	protein-(glutamine-N5) methyltransferase activity
I3J23_07935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I3J23_07940	COG0346	lactoylglutathione lyase activity
I3J23_07945	COG0789	Transcriptional regulator
I3J23_07950	COG0679	Auxin Efflux Carrier
I3J23_07955	COG0281	malic enzyme
I3J23_07970	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I3J23_07975	COG1494	fructose-1,6-bisphosphatase
I3J23_07980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3J23_07990	COG0191	fructose-bisphosphate aldolase activity
I3J23_07995	COG2204	response regulator
I3J23_08000	COG4821	SIS domain
I3J23_08015	COG0247	lactate metabolic process
I3J23_08015	COG2181	nitrate reductase activity
I3J23_08020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3J23_08035	COG1132	(ABC) transporter
I3J23_08040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I3J23_08050	COG2181	nitrate reductase activity
I3J23_08055	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I3J23_08060	COG1140	nitrate reductase beta subunit
I3J23_08065	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I3J23_08070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J23_08080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J23_08085	COG2223	nitrite transmembrane transporter activity
I3J23_08095	COG4506	Protein conserved in bacteria
I3J23_08100	COG0457	Tetratricopeptide repeat
I3J23_08135	COG0010	Belongs to the arginase family
I3J23_08140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I3J23_08145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J23_08160	COG1994	Peptidase M50
I3J23_08165	COG1942	4-Oxalocrotonate Tautomerase
I3J23_08170	COG1846	Transcriptional regulator
I3J23_08175	COG0531	amino acid
I3J23_08180	COG3465	dGTPase activity
I3J23_08185	COG1078	dGTPase activity
I3J23_08200	COG1695	Transcriptional regulator
I3J23_08210	COG1131	(ABC) transporter
I3J23_08215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I3J23_08245	COG0583	DNA-binding transcription factor activity
I3J23_08250	COG2855	membrane
I3J23_08255	COG0280	phosphate acetyltransferase
I3J23_08265	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_08270	COG0436	Aminotransferase
I3J23_08300	COG2814	Major facilitator Superfamily
I3J23_08305	COG2814	Major facilitator Superfamily
I3J23_08310	COG0833	amino acid
I3J23_08315	COG4187	Peptidase family M20/M25/M40
I3J23_08320	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_08325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3J23_08335	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I3J23_08340	COG1091	dTDP-4-dehydrorhamnose reductase activity
I3J23_08345	COG1088	dTDP-glucose 4,6-dehydratase activity
I3J23_08350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I3J23_08355	COG3980	spore coat polysaccharide biosynthesis protein
I3J23_08360	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I3J23_08365	COG2089	acid synthase
I3J23_08370	COG0456	acetyltransferase
I3J23_08375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I3J23_08380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I3J23_08385	COG0463	Glycosyl transferase, family 2
I3J23_08395	COG2363	Small membrane protein
I3J23_08400	COG2233	PERMEase
I3J23_08415	COG1216	Glycosyl transferase, family 2
I3J23_08430	COG1695	Transcriptional regulator
I3J23_08435	COG0351	phosphomethylpyrimidine kinase
I3J23_08445	COG1621	beta-fructofuranosidase activity
I3J23_08450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_08450	COG1263	PTS System
I3J23_08455	COG3711	transcriptional antiterminator
I3J23_08465	COG1404	Belongs to the peptidase S8 family
I3J23_08470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_08475	COG0778	Nitroreductase
I3J23_08480	COG0772	Belongs to the SEDS family
I3J23_08485	COG0454	-acetyltransferase
I3J23_08505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J23_08510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J23_08515	COG2261	transglycosylase associated protein
I3J23_08520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I3J23_08530	COG2246	polysaccharide biosynthetic process
I3J23_08535	COG1309	transcriptional regulator
I3J23_08555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J23_08560	COG2837	iron assimilation
I3J23_08585	COG0583	DNA-binding transcription factor activity
I3J23_08595	COG1346	cytolysis
I3J23_08600	COG4895	conserved protein (DUF2196)
I3J23_08605	COG0789	Transcriptional regulator
I3J23_08610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I3J23_08615	COG0346	lactoylglutathione lyase activity
I3J23_08620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_08625	COG1404	Belongs to the peptidase S8 family
I3J23_08630	COG1442	glycosyl transferase family 8
I3J23_08635	COG2357	RelA SpoT domain protein
I3J23_08640	COG1575	Belongs to the MenA family. Type 1 subfamily
I3J23_08655	COG1696	Membrane protein involved in D-alanine export
I3J23_08665	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I3J23_08670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J23_08675	COG1486	melibiose metabolic process
I3J23_08680	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3J23_08685	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_08690	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_08695	COG3711	transcriptional antiterminator
I3J23_08695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_08705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_08710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_08720	COG0640	Transcriptional regulator
I3J23_08725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3J23_08730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_08735	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3J23_08740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_08745	COG2723	6-phospho-beta-galactosidase activity
I3J23_08750	COG1940	carbohydrate kinase activity
I3J23_08755	COG1482	cell wall glycoprotein biosynthetic process
I3J23_08765	COG0753	catalase activity
I3J23_08770	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I3J23_08775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I3J23_08780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I3J23_08785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I3J23_08790	COG4988	ABC transporter
I3J23_08795	COG1294	oxidase, subunit
I3J23_08800	COG1271	oxidase subunit
I3J23_08805	COG3493	citrate carrier protein
I3J23_08810	COG0726	polysaccharide deacetylase
I3J23_08815	COG3842	ATPase activity
I3J23_08820	COG2508	Transcriptional regulator
I3J23_08825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_08835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J23_08850	COG4894	glucomannan catabolic process
I3J23_08855	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I3J23_08860	COG0500	methyltransferase
I3J23_08865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3J23_08880	COG0753	catalase activity
I3J23_08880	COG0693	protein deglycase activity
I3J23_08885	COG2851	Citrate transporter
I3J23_08890	COG2273	Hydrolase Family 16
I3J23_08900	COG2270	Major facilitator Superfamily
I3J23_08905	COG0513	Belongs to the DEAD box helicase family
I3J23_08975	COG0697	spore germination
I3J23_08980	COG0589	response to stress
I3J23_08990	COG0494	nUDIX hydrolase
I3J23_08995	COG3507	Belongs to the glycosyl hydrolase 43 family
I3J23_09020	COG0010	Belongs to the arginase family
I3J23_09025	COG0833	amino acid
I3J23_09030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I3J23_09035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I3J23_09045	COG2390	Transcriptional regulator
I3J23_09050	COG0561	phosphatase activity
I3J23_09080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J23_09085	COG5294	Protein conserved in bacteria
I3J23_09090	COG0577	efflux transmembrane transporter activity
I3J23_09095	COG1136	(ABC) transporter
I3J23_09100	COG2205	protein histidine kinase activity
I3J23_09105	COG0745	RESPONSE REGULATOR receiver
I3J23_09120	COG1082	Xylose isomerase domain protein TIM barrel
I3J23_09130	COG2814	Major facilitator Superfamily
I3J23_09160	COG1349	DNA-binding transcription factor activity
I3J23_09165	COG0667	Aldo Keto reductase
I3J23_09170	COG2814	Major facilitator Superfamily
I3J23_09180	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_09185	COG2197	response regulator
I3J23_09190	COG4585	Histidine kinase
I3J23_09195	COG3239	Fatty acid desaturase
I3J23_09200	COG1309	transcriptional regulator
I3J23_09205	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_09210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I3J23_09220	COG0640	Transcriptional regulator
I3J23_09225	COG2814	Major facilitator Superfamily
I3J23_09230	COG1714	RDD family
I3J23_09240	COG0450	alkyl hydroperoxide reductase
I3J23_09245	COG3634	alkyl hydroperoxide reductase activity
I3J23_09250	COG1113	amino acid transport
I3J23_09260	COG2080	2 iron, 2 sulfur cluster binding
I3J23_09275	COG2068	MobA-Related Protein
I3J23_09280	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I3J23_09335	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I3J23_09340	COG0667	Aldo Keto reductase
I3J23_09345	COG0456	acetyltransferase
I3J23_09350	COG0457	Tetratricopeptide repeat
I3J23_09355	COG0010	Belongs to the arginase family
I3J23_09360	COG0833	amino acid
I3J23_09365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J23_09370	COG3829	transcription factor binding
I3J23_09380	COG0488	(ABC) transporter
I3J23_09395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3J23_09400	COG3850	Histidine kinase
I3J23_09400	COG5002	protein histidine kinase activity
I3J23_09405	COG0745	RESPONSE REGULATOR receiver
I3J23_09410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J23_09415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I3J23_09420	COG4853	Protein conserved in bacteria
I3J23_09425	COG4863	YycH protein
I3J23_09430	COG5002	protein histidine kinase activity
I3J23_09435	COG0745	RESPONSE REGULATOR receiver
I3J23_09465	COG0346	lactoylglutathione lyase activity
I3J23_09470	COG0305	Participates in initiation and elongation during chromosome replication
I3J23_09485	COG3093	addiction module antidote protein HigA
I3J23_09490	COG0297	glycogen (starch) synthase activity
I3J23_09500	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I3J23_09505	COG0438	transferase activity, transferring glycosyl groups
I3J23_09515	COG0515	serine threonine protein kinase
I3J23_09525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I3J23_09530	COG4241	membrane
I3J23_09540	COG5577	PFAM Coat F domain
I3J23_09545	COG1733	regulation of RNA biosynthetic process
I3J23_09555	COG0697	spore germination
I3J23_09560	COG1621	beta-fructofuranosidase activity
I3J23_09565	COG1621	beta-fructofuranosidase activity
I3J23_09570	COG1802	Transcriptional regulator
I3J23_09575	COG2318	DinB family
I3J23_09580	COG2211	Major facilitator Superfamily
I3J23_09590	COG0778	Nitroreductase
I3J23_09595	COG1846	Transcriptional regulator
I3J23_09600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_09605	COG1846	Transcriptional regulator
I3J23_09620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I3J23_09625	COG0583	DNA-binding transcription factor activity
I3J23_09630	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_09635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J23_09640	COG0697	spore germination
I3J23_09655	COG1959	2 iron, 2 sulfur cluster binding
I3J23_09670	COG1331	Highly conserved protein containing a thioredoxin domain
I3J23_09675	COG1266	CAAX protease self-immunity
I3J23_09680	COG0477	Major facilitator Superfamily
I3J23_09680	COG2814	Major facilitator Superfamily
I3J23_09685	COG0346	lactoylglutathione lyase activity
I3J23_09690	COG1609	Transcriptional regulator
I3J23_09695	COG0708	Exodeoxyribonuclease III
I3J23_09700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J23_09705	COG2169	Transcriptional regulator
I3J23_09715	COG0629	single-stranded DNA binding
I3J23_09725	COG0012	GTP binding
I3J23_09730	COG0243	molybdopterin cofactor binding
I3J23_09735	COG4481	Protein conserved in bacteria
I3J23_09740	COG3949	Membrane
I3J23_09755	COG1475	DNA binding
I3J23_09760	COG1192	Involved in chromosome partitioning
I3J23_09785	COG1847	R3H domain protein
I3J23_09790	COG0706	membrane insertase activity
I3J23_09810	COG0592	DNA-directed DNA polymerase activity
I3J23_09815	COG2501	S4 domain
I3J23_09830	COG0187	DNA topoisomerase II activity
I3J23_09835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J23_09870	COG0516	GMP reductase activity
I3J23_09870	COG0517	IMP dehydrogenase activity
I3J23_09875	COG1686	Belongs to the peptidase S11 family
I3J23_09895	COG1929	Belongs to the glycerate kinase type-1 family
I3J23_09905	COG1428	Deoxynucleoside kinase
I3J23_09910	COG1428	Deoxynucleoside kinase
I3J23_09915	COG1388	LysM domain
I3J23_09915	COG3858	chitin binding
I3J23_09920	COG1335	isochorismatase
I3J23_09925	COG0590	tRNA wobble adenosine to inosine editing
I3J23_09935	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I3J23_09940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I3J23_09990	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I3J23_09995	COG3853	Toxic anion resistance protein (TelA)
I3J23_10000	COG1982	Orn Lys Arg decarboxylase major
I3J23_10010	COG3870	Protein conserved in bacteria
I3J23_10015	COG1728	Protein conserved in bacteria
I3J23_10020	COG0470	DNA polymerase III
I3J23_10025	COG1774	PSP1 C-terminal conserved region
I3J23_10035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I3J23_10045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I3J23_10050	COG2002	toxin-antitoxin pair type II binding
I3J23_10055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J23_10055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J23_10060	COG0084	hydrolase, TatD family'
I3J23_10065	COG3584	3D domain protein
I3J23_10065	COG3583	domain protein
I3J23_10070	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I3J23_10075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I3J23_10085	COG4466	Protein conserved in bacteria
I3J23_10100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3J23_10105	COG0251	oxidation-reduction process
I3J23_10120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I3J23_10140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I3J23_10145	COG2002	toxin-antitoxin pair type II binding
I3J23_10150	COG2244	polysaccharide biosynthetic process
I3J23_10155	COG3956	TIGRFAM MazG family protein
I3J23_10160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I3J23_10175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I3J23_10180	COG1098	S1 RNA binding domain
I3J23_10195	COG2208	phosphoserine phosphatase activity
I3J23_10200	COG2304	oxidoreductase activity
I3J23_10205	COG0515	serine threonine protein kinase
I3J23_10210	COG0037	tRNA processing
I3J23_10215	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3J23_10220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3J23_10235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3J23_10240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I3J23_10245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I3J23_10250	COG0512	Glutamine amidotransferase of anthranilate synthase
I3J23_10255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J23_10260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3J23_10265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3J23_10270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I3J23_10275	COG1396	sequence-specific DNA binding
I3J23_10280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3J23_10285	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3J23_10365	COG4463	regulation of RNA biosynthetic process
I3J23_10370	COG3880	PFAM UvrB UvrC protein
I3J23_10380	COG0542	response to heat
I3J23_10385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I3J23_10390	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I3J23_10395	COG4956	integral membrane protein (PIN domain superfamily)
I3J23_10415	COG1045	serine acetyltransferase
I3J23_10425	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I3J23_10430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3J23_10435	COG3688	RNA-binding protein containing a PIN domain
I3J23_10440	COG1595	DNA-templated transcription, initiation
I3J23_10450	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3J23_10455	COG0250	Participates in transcription elongation, termination and antitermination
I3J23_10480	COG2813	Specifically methylates the guanine in position
I3J23_10495	COG1358	cellular component organization or biogenesis
I3J23_10520	COG0596	Alpha beta hydrolase
I3J23_10630	COG0201	protein transport
I3J23_10640	COG0024	Methionine aminopeptidase
I3J23_10650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I3J23_10675	COG1122	ATPase activity
I3J23_10680	COG1122	ATPase activity
I3J23_10685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I3J23_10705	COG2226	methyltransferase
I3J23_10710	COG2318	DinB family
I3J23_10720	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_10725	COG0489	protein tyrosine kinase activity
I3J23_10735	COG2194	sulfuric ester hydrolase activity
I3J23_10740	COG0726	polysaccharide deacetylase
I3J23_10800	COG0738	Major facilitator superfamily
I3J23_10805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J23_10820	COG0659	secondary active sulfate transmembrane transporter activity
I3J23_10825	COG0385	Bile acid
I3J23_10830	COG2819	hydrolase of the alpha beta superfamily
I3J23_10835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J23_10850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I3J23_10850	COG2207	Transcriptional regulator
I3J23_10855	COG3876	Protein conserved in bacteria
I3J23_10860	COG1472	Belongs to the glycosyl hydrolase 3 family
I3J23_10865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J23_10870	COG1263	PTS System
I3J23_10870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_10880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J23_10885	COG1683	Conserved Protein
I3J23_10915	COG1595	DNA-templated transcription, initiation
I3J23_10920	COG5662	AntiSigma factor
I3J23_10925	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I3J23_10930	COG4856	YbbR-like protein
I3J23_10970	COG1346	cytolysis
I3J23_10975	COG1380	Effector of murein hydrolase LrgA
I3J23_10980	COG1846	Transcriptional regulator
I3J23_10985	COG1113	amino acid transport
I3J23_10990	COG1011	Hydrolase
I3J23_10995	COG4585	Histidine kinase
I3J23_11000	COG2197	response regulator
I3J23_11005	COG1131	(ABC) transporter
I3J23_11045	COG0531	amino acid
I3J23_11050	COG0584	glycerophosphoryl diester phosphodiesterase
I3J23_11055	COG2271	Major facilitator Superfamily
I3J23_11065	COG2368	4-hydroxyphenylacetate
I3J23_11075	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_11090	COG0371	Dehydrogenase
I3J23_11100	COG1183	phosphatidylcholine synthase activity
I3J23_11105	COG0586	Pfam SNARE associated Golgi protein
I3J23_11110	COG0688	phosphatidylethanolamine metabolic process
I3J23_11125	COG1301	dicarboxylic acid transport
I3J23_11130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J23_11135	COG0833	amino acid
I3J23_11140	COG2040	homocysteine
I3J23_11145	COG1115	amino acid carrier protein
I3J23_11150	COG2066	Belongs to the glutaminase family
I3J23_11155	COG4191	Histidine kinase
I3J23_11160	COG0784	Response regulator, receiver
I3J23_11165	COG3173	Aminoglycoside phosphotransferase
I3J23_11175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I3J23_11180	COG0778	Nitroreductase
I3J23_11185	COG0346	lactoylglutathione lyase activity
I3J23_11190	COG2259	Doxx family
I3J23_11195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_11205	COG3773	Cell wall hydrolase
I3J23_11210	COG3540	Alkaline phosphatase
I3J23_11215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J23_11220	COG0805	protein transport
I3J23_11230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3J23_11235	COG0477	Major facilitator Superfamily
I3J23_11240	COG1309	transcriptional regulator
I3J23_11245	COG0252	asparaginase activity
I3J23_11250	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I3J23_11255	COG3012	SEC-C Motif Domain Protein
I3J23_11255	COG1405	negative regulation of cell septum assembly
I3J23_11260	COG0667	Aldo Keto reductase
I3J23_11270	COG1595	DNA-templated transcription, initiation
I3J23_11275	COG1595	DNA-templated transcription, initiation
I3J23_11280	COG1876	peptidase activity
I3J23_11285	COG0457	Tetratricopeptide repeat
I3J23_11290	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_11295	COG0366	Alpha amylase catalytic
I3J23_11300	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3J23_11305	COG1121	(ABC) transporter
I3J23_11310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I3J23_11315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_11320	COG2310	stress, protein
I3J23_11325	COG2310	stress, protein
I3J23_11330	COG2310	stress, protein
I3J23_11335	COG0861	Integral membrane protein TerC family
I3J23_11345	COG3853	Toxic anion resistance protein (TelA)
I3J23_11350	COG0477	Major facilitator Superfamily
I3J23_11355	COG0517	IMP dehydrogenase activity
I3J23_11355	COG4175	Glycine betaine
I3J23_11360	COG4176	ABC-type proline glycine betaine transport system permease component
I3J23_11365	COG2113	Glycine betaine
I3J23_11370	COG1473	amidohydrolase
I3J23_11375	COG1288	antiporter activity
I3J23_11385	COG0366	Alpha amylase catalytic
I3J23_11395	COG2814	Major facilitator Superfamily
I3J23_11400	COG1846	Transcriptional regulator
I3J23_11405	COG1280	lysine exporter protein (LysE YggA)
I3J23_11410	COG3403	YqcI/YcgG family
I3J23_11415	COG1113	amino acid transport
I3J23_11420	COG3665	Urea carboxylase-associated protein
I3J23_11435	COG1660	Displays ATPase and GTPase activities
I3J23_11445	COG2271	Major facilitator Superfamily
I3J23_11450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I3J23_11455	COG3458	cephalosporin-C deacetylase activity
I3J23_11460	COG3541	Predicted nucleotidyltransferase
I3J23_11465	COG0506	proline dehydrogenase activity
I3J23_11470	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_11475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J23_11480	COG2508	Transcriptional regulator
I3J23_11490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J23_11490	COG1587	Uroporphyrinogen-III synthase
I3J23_11495	COG2146	nitrite reductase [NAD(P)H] activity
I3J23_11500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I3J23_11505	COG0523	cobalamin synthesis protein
I3J23_11510	COG1063	alcohol dehydrogenase
I3J23_11515	COG1714	RDD family
I3J23_11525	COG2723	6-phospho-beta-galactosidase activity
I3J23_11540	COG3209	COG3209 Rhs family protein
I3J23_11545	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I3J23_11550	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I3J23_11555	COG1733	regulation of RNA biosynthetic process
I3J23_11560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_11565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_11570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_11575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I3J23_11590	COG2364	Membrane
I3J23_11595	COG1126	abc transporter atp-binding protein
I3J23_11600	COG0765	amino acid transport
I3J23_11605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_11610	COG0583	DNA-binding transcription factor activity
I3J23_11615	COG0163	prenyltransferase activity
I3J23_11620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I3J23_11635	COG3104	oligopeptide transport
I3J23_11640	COG5434	Belongs to the glycosyl hydrolase 28 family
I3J23_11650	COG0697	spore germination
I3J23_11660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I3J23_11665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I3J23_11670	COG0456	acetyltransferase
I3J23_11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3J23_11680	COG0765	amino acid transport
I3J23_11685	COG1126	abc transporter atp-binding protein
I3J23_11690	COG1473	amidohydrolase
I3J23_11695	COG2079	MmgE PrpD family protein
I3J23_11700	COG1136	(ABC) transporter
I3J23_11705	COG0577	efflux transmembrane transporter activity
I3J23_11710	COG0745	RESPONSE REGULATOR receiver
I3J23_11715	COG5002	protein histidine kinase activity
I3J23_11715	COG3850	Histidine kinase
I3J23_11720	COG0457	Tetratricopeptide repeat
I3J23_11735	COG0527	aspartate kinase activity
I3J23_11740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I3J23_11745	COG4605	iron ion homeostasis
I3J23_11750	COG4604	ABC transporter, ATP-binding protein
I3J23_11755	COG4607	ABC-type enterochelin transport system periplasmic component
I3J23_11760	COG2814	Major facilitator Superfamily
I3J23_11765	COG1309	transcriptional regulator
I3J23_11770	COG0778	Nitroreductase
I3J23_11775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I3J23_11780	COG0640	Transcriptional regulator
I3J23_11785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J23_11790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I3J23_11795	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_11800	COG4975	Glucose uptake
I3J23_11805	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_11810	COG4549	nuclear export factor GLE1
I3J23_11815	COG2372	response to copper ion
I3J23_11815	COG1276	copper resistance
I3J23_11820	COG1349	DNA-binding transcription factor activity
I3J23_11830	COG2213	PTS system mannitol-specific
I3J23_11835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_11845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I3J23_11855	COG0561	phosphatase activity
I3J23_11865	COG1914	H( )-stimulated, divalent metal cation uptake system
I3J23_11875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I3J23_11880	COG1984	allophanate hydrolase subunit 2
I3J23_11885	COG1414	Transcriptional regulator
I3J23_11890	COG2755	lipolytic protein G-D-S-L family
I3J23_11900	COG2329	Antibiotic biosynthesis monooxygenase
I3J23_11905	COG0768	penicillin binding
I3J23_11910	COG4989	oxidoreductase activity
I3J23_11915	COG3711	transcriptional antiterminator
I3J23_11920	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_11925	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_11930	COG1917	Cupin 2, conserved barrel domain protein
I3J23_11935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J23_11940	COG3871	stress protein (general stress protein 26)
I3J23_11950	COG2814	Major facilitator Superfamily
I3J23_11955	COG1522	sequence-specific DNA binding
I3J23_11960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J23_11960	COG0551	DNA topoisomerase type I activity
I3J23_11965	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I3J23_11970	COG3706	GGDEF domain
I3J23_11975	COG5298	Protein conserved in bacteria
I3J23_11980	COG1215	transferase activity, transferring glycosyl groups
I3J23_11990	COG0531	amino acid
I3J23_11995	COG0494	nUDIX hydrolase
I3J23_12000	COG0028	Belongs to the TPP enzyme family
I3J23_12055	COG0457	Tetratricopeptide repeat
I3J23_12075	COG1914	H( )-stimulated, divalent metal cation uptake system
I3J23_12085	COG4876	unkown
I3J23_12095	COG2076	Multidrug Resistance protein
I3J23_12100	COG2217	Heavy metal translocating P-type atpase
I3J23_12105	COG3729	General stress protein
I3J23_12110	COG0662	Cupin 2, conserved barrel domain protein
I3J23_12115	COG2329	Antibiotic biosynthesis monooxygenase
I3J23_12120	COG3546	catalase activity
I3J23_12125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I3J23_12130	COG3290	protein histidine kinase activity
I3J23_12135	COG4565	transcriptional regulatory protein
I3J23_12140	COG1301	dicarboxylic acid transport
I3J23_12145	COG0628	permease
I3J23_12150	COG1131	(ABC) transporter
I3J23_12155	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I3J23_12165	COG1960	acyl-CoA dehydrogenase activity
I3J23_12180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I3J23_12185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_12195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3J23_12200	COG0513	Belongs to the DEAD box helicase family
I3J23_12205	COG3402	PFAM membrane-flanked domain
I3J23_12210	COG3428	Bacterial PH domain
I3J23_12215	COG0705	Rhomboid family
I3J23_12225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I3J23_12230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3J23_12235	COG0864	Transcriptional regulator
I3J23_12240	COG2337	Toxic component of a toxin-antitoxin (TA) module
I3J23_12245	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_12250	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_12255	COG2172	sigma factor antagonist activity
I3J23_12260	COG2208	phosphoserine phosphatase activity
I3J23_12265	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_12275	COG1191	sigma factor activity
I3J23_12280	COG2208	phosphoserine phosphatase activity
I3J23_12285	COG2183	response to ionizing radiation
I3J23_12335	COG0457	Tetratricopeptide repeat
I3J23_12340	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3J23_12355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I3J23_12360	COG0477	Major facilitator Superfamily
I3J23_12370	COG1764	response to oxidative stress
I3J23_12375	COG1846	Transcriptional regulator
I3J23_12385	COG2030	dehydratase
I3J23_12395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I3J23_12400	COG1959	2 iron, 2 sulfur cluster binding
I3J23_12405	COG2910	NAD(P)H-binding
I3J23_12410	COG1278	Cold shock
I3J23_12420	COG1937	Protein conserved in bacteria
I3J23_12425	COG2210	Belongs to the sulfur carrier protein TusA family
I3J23_12435	COG0425	Belongs to the sulfur carrier protein TusA family
I3J23_12435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J23_12440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_12440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3J23_12445	COG0425	Belongs to the sulfur carrier protein TusA family
I3J23_12450	COG0730	response to heat
I3J23_12455	COG1794	racemase activity, acting on amino acids and derivatives
I3J23_12470	COG3621	Patatin-like phospholipase
I3J23_12480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3J23_12485	COG1802	Transcriptional regulator
I3J23_12490	COG0251	oxidation-reduction process
I3J23_12495	COG0814	amino acid
I3J23_12500	COG1473	amidohydrolase
I3J23_12505	COG1917	Cupin 2, conserved barrel domain protein
I3J23_12505	COG2207	Transcriptional regulator
I3J23_12515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J23_12520	COG0477	Major facilitator Superfamily
I3J23_12540	COG0277	FAD linked oxidase domain protein
I3J23_12570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I3J23_12595	COG1064	alcohol dehydrogenase
I3J23_12600	COG0789	Transcriptional regulator
I3J23_12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3J23_12625	COG2814	Major facilitator Superfamily
I3J23_12630	COG1309	transcriptional regulator
I3J23_12635	COG5577	PFAM Coat F domain
I3J23_12645	COG1063	alcohol dehydrogenase
I3J23_12650	COG5577	PFAM Coat F domain
I3J23_12660	COG4585	Histidine kinase
I3J23_12665	COG2197	response regulator
I3J23_12670	COG2409	Drug exporters of the RND superfamily
I3J23_12675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3J23_12680	COG0488	(ABC) transporter
I3J23_12685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J23_12690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_12700	COG2814	Major facilitator Superfamily
I3J23_12705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J23_12715	COG0730	response to heat
I3J23_12720	COG0456	acetyltransferase
I3J23_12725	COG4978	Transcriptional regulator
I3J23_12725	COG0789	Transcriptional regulator
I3J23_12730	COG0697	spore germination
I3J23_12735	COG1051	belongs to the nudix hydrolase family
I3J23_12740	COG2226	methyltransferase
I3J23_12745	COG0473	3-isopropylmalate dehydrogenase activity
I3J23_12750	COG1802	Transcriptional regulator
I3J23_12755	COG1819	glycosyl
I3J23_12770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J23_12780	COG1388	LysM domain
I3J23_12785	COG2814	Major facilitator Superfamily
I3J23_12790	COG2188	Transcriptional regulator
I3J23_12795	COG2186	Transcriptional regulator
I3J23_12800	COG2807	transmembrane transport
I3J23_12805	COG2076	Multidrug Resistance protein
I3J23_12810	COG2076	Multidrug Resistance protein
I3J23_12815	COG1309	transcriptional regulator
I3J23_12820	COG0531	amino acid
I3J23_12830	COG3832	glyoxalase III activity
I3J23_12835	COG0604	alcohol dehydrogenase
I3J23_12840	COG2814	Major facilitator Superfamily
I3J23_12880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I3J23_12885	COG0802	atpase or kinase
I3J23_12890	COG1214	PFAM Peptidase M22, glycoprotease
I3J23_12895	COG0456	acetyltransferase
I3J23_12900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I3J23_12905	COG0488	(ABC) transporter
I3J23_12920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I3J23_12925	COG0805	protein transport
I3J23_12935	COG1266	CAAX protease self-immunity
I3J23_12995	COG1131	(ABC) transporter
I3J23_13000	COG0842	Transport permease protein
I3J23_13005	COG0457	Tetratricopeptide repeat
I3J23_13010	COG1063	alcohol dehydrogenase
I3J23_13015	COG2211	Major facilitator Superfamily
I3J23_13020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3J23_13030	COG1842	Phage shock protein A
I3J23_13035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3J23_13040	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I3J23_13045	COG4260	virion core protein, lumpy skin disease virus
I3J23_13050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3J23_13050	COG2755	lipolytic protein G-D-S-L family
I3J23_13060	COG1595	DNA-templated transcription, initiation
I3J23_13065	COG1063	alcohol dehydrogenase
I3J23_13070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I3J23_13075	COG0823	Involved in the tonB-independent uptake of proteins
I3J23_13090	COG2132	Multicopper oxidase
I3J23_13095	COG1113	amino acid transport
I3J23_13100	COG0714	Associated with various cellular activities
I3J23_13105	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I3J23_13110	COG1305	Transglutaminase-like
I3J23_13130	COG2252	PERMEase
I3J23_13135	COG3064	Membrane
I3J23_13155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3J23_13160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3J23_13165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3J23_13170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I3J23_13175	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3J23_13190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I3J23_13200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I3J23_13205	COG0138	bifunctional purine biosynthesis protein purh
I3J23_13210	COG0151	Belongs to the GarS family
I3J23_13220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I3J23_13225	COG1470	cell adhesion involved in biofilm formation
I3J23_13230	COG4496	protein, YerC YecD
I3J23_13235	COG0069	glutamate synthase activity
I3J23_13245	COG0210	DNA helicase
I3J23_13255	COG4851	CamS sex pheromone cAM373 precursor
I3J23_13260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I3J23_13265	COG1285	pathogenesis
I3J23_13270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J23_13290	COG1309	transcriptional regulator
I3J23_13295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I3J23_13300	COG1597	lipid kinase activity
I3J23_13305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J23_13315	COG1131	(ABC) transporter
I3J23_13340	COG5444	nuclease activity
I3J23_13375	COG3546	catalase activity
I3J23_13380	COG0454	-acetyltransferase
I3J23_13390	COG2323	membrane
I3J23_13395	COG2329	Antibiotic biosynthesis monooxygenase
I3J23_13400	COG0346	lactoylglutathione lyase activity
I3J23_13405	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_13410	COG5583	Uncharacterized small protein (DUF2292)
I3J23_13415	COG0196	riboflavin kinase activity
I3J23_13420	COG0670	Belongs to the BI1 family
I3J23_13430	COG1846	Transcriptional regulator
I3J23_13435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J23_13445	COG2124	cytochrome p450
I3J23_13445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I3J23_13460	COG1131	(ABC) transporter
I3J23_13505	COG4106	trans-aconitate 2-methyltransferase activity
I3J23_13510	COG1368	sulfuric ester hydrolase activity
I3J23_13515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I3J23_13520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_13525	COG1442	glycosyl transferase family 8
I3J23_13530	COG1216	Glycosyl transferase, family 2
I3J23_13535	COG1442	glycosyl transferase family 8
I3J23_13540	COG2223	nitrite transmembrane transporter activity
I3J23_13545	COG0531	amino acid
I3J23_13550	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_13555	COG0840	transmembrane signaling receptor activity
I3J23_13560	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_13565	COG0463	Glycosyl transferase, family 2
I3J23_13565	COG0457	Tetratricopeptide repeat
I3J23_13570	COG0488	(ABC) transporter
I3J23_13575	COG0789	Transcriptional regulator
I3J23_13580	COG2814	Major facilitator Superfamily
I3J23_13585	COG0488	(ABC) transporter
I3J23_13590	COG0513	Belongs to the DEAD box helicase family
I3J23_13600	COG2130	NADP-dependent
I3J23_13615	COG3866	Pectate lyase
I3J23_13620	COG0471	metal ion transport
I3J23_13640	COG0745	RESPONSE REGULATOR receiver
I3J23_13640	COG2972	Histidine kinase
I3J23_13645	COG3279	Response regulator of the LytR AlgR family
I3J23_13655	COG3764	Sortase (surface protein transpeptidase)
I3J23_13660	COG3290	protein histidine kinase activity
I3J23_13665	COG4565	transcriptional regulatory protein
I3J23_13670	COG3181	Tripartite tricarboxylate transporter family receptor
I3J23_13675	COG2851	Citrate transporter
I3J23_13680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_13685	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I3J23_13695	COG2258	MOSC domain
I3J23_13715	COG0024	Methionine aminopeptidase
I3J23_13720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_13720	COG1263	PTS System
I3J23_13730	COG1368	sulfuric ester hydrolase activity
I3J23_13740	COG0071	Belongs to the small heat shock protein (HSP20) family
I3J23_13755	COG1263	PTS System
I3J23_13755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_13760	COG0366	Alpha amylase catalytic
I3J23_13765	COG2188	Transcriptional regulator
I3J23_13770	COG0778	Nitroreductase
I3J23_13785	COG0737	Belongs to the 5'-nucleotidase family
I3J23_13790	COG0693	protein deglycase activity
I3J23_13795	COG1609	Transcriptional regulator
I3J23_13810	COG2814	Major facilitator Superfamily
I3J23_13820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3J23_13825	COG4980	gas vesicle protein
I3J23_13830	COG1295	ribonuclease BN
I3J23_13835	COG0477	Major facilitator Superfamily
I3J23_13840	COG0387	Pfam Sodium calcium exchanger
I3J23_13850	COG0668	transmembrane transport
I3J23_13855	COG0535	radical SAM domain protein
I3J23_13865	COG0726	polysaccharide deacetylase
I3J23_13870	COG2084	Dehydrogenase
I3J23_13880	COG0598	Magnesium transport protein CorA
I3J23_13885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I3J23_13890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I3J23_13900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I3J23_13905	COG4637	Psort location Cytoplasmic, score
I3J23_13910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I3J23_13915	COG0022	dehydrogenase e1 component
I3J23_13920	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J23_13925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J23_13930	COG3284	Transcriptional regulator
I3J23_13940	COG1486	melibiose metabolic process
I3J23_13945	COG1737	Transcriptional regulator
I3J23_13950	COG1263	PTS System
I3J23_13950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_13955	COG1132	(ABC) transporter
I3J23_13960	COG1132	(ABC) transporter
I3J23_13965	COG2259	Doxx family
I3J23_13970	COG2514	catechol 2,3-dioxygenase activity
I3J23_13980	COG1695	Transcriptional regulator
I3J23_13985	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3J23_13990	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I3J23_13995	COG3848	Pyruvate phosphate dikinase
I3J23_13995	COG0574	Belongs to the PEP-utilizing enzyme family
I3J23_14000	COG2732	(Barnase) inhibitor
I3J23_14005	COG2318	DinB family
I3J23_14010	COG2814	Major facilitator Superfamily
I3J23_14015	COG1846	Transcriptional regulator
I3J23_14020	COG0392	lysyltransferase activity
I3J23_14020	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I3J23_14025	COG0384	phenazine biosynthesis protein PhzF
I3J23_14030	COG0778	Nitroreductase
I3J23_14045	COG1090	epimerase
I3J23_14060	COG2814	Major facilitator Superfamily
I3J23_14070	COG3591	Belongs to the peptidase S1B family
I3J23_14085	COG3103	Sh3 type 3 domain protein
I3J23_14090	COG5658	integral membrane protein
I3J23_14095	COG0596	Alpha beta hydrolase
I3J23_14100	COG0463	Glycosyl transferase, family 2
I3J23_14105	COG4485	Bacterial membrane protein, YfhO
I3J23_14110	COG1988	membrane-bound metal-dependent
I3J23_14115	COG1194	a g-specific adenine glycosylase
I3J23_14125	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_14145	COG1132	(ABC) transporter
I3J23_14150	COG4129	membrane
I3J23_14160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I3J23_14165	COG0735	belongs to the Fur family
I3J23_14275	COG3340	Belongs to the peptidase S51 family
I3J23_14285	COG0277	FAD linked oxidase domain protein
I3J23_14295	COG0747	negative chemotaxis
I3J23_14300	COG0601	transmembrane transport
I3J23_14305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J23_14310	COG0444	Belongs to the ABC transporter superfamily
I3J23_14315	COG4608	Belongs to the ABC transporter superfamily
I3J23_14320	COG0753	catalase activity
I3J23_14330	COG1116	anion transmembrane transporter activity
I3J23_14335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I3J23_14340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3J23_14360	COG1476	TRANSCRIPTIONal
I3J23_14370	COG3382	B3 4 domain protein
I3J23_14375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I3J23_14385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3J23_14390	COG0789	Transcriptional regulator
I3J23_14395	COG1664	Polymer-forming cytoskeletal
I3J23_14400	COG1664	Polymer-forming cytoskeletal
I3J23_14405	COG2766	serine protein kinase
I3J23_14415	COG1846	Transcriptional regulator
I3J23_14420	COG1566	PFAM secretion protein HlyD family protein
I3J23_14425	COG2814	Major facilitator Superfamily
I3J23_14430	COG0655	NAD(P)H dehydrogenase (quinone) activity
I3J23_14445	COG1725	Transcriptional regulator
I3J23_14450	COG1131	(ABC) transporter
I3J23_14455	COG1131	(ABC) transporter
I3J23_14460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I3J23_14465	COG1278	Cold shock
I3J23_14470	COG1464	Belongs to the NlpA lipoprotein family
I3J23_14475	COG3706	GGDEF domain
I3J23_14480	COG1823	symporter activity
I3J23_14500	COG5577	PFAM Coat F domain
I3J23_14505	COG0737	Belongs to the 5'-nucleotidase family
I3J23_14505	COG1525	nuclease
I3J23_14505	COG4085	toxin activity
I3J23_14510	COG3764	Sortase (surface protein transpeptidase)
I3J23_14515	COG0564	pseudouridine synthase activity
I3J23_14525	COG0517	IMP dehydrogenase activity
I3J23_14530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3J23_14535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J23_14535	COG3153	acetyltransferase
I3J23_14540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J23_14545	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I3J23_14550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3J23_14560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I3J23_14565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I3J23_14580	COG0431	NADPH-dependent FMN reductase
I3J23_14595	COG0791	NLP P60 protein
I3J23_14595	COG1388	LysM domain
I3J23_14600	COG1959	2 iron, 2 sulfur cluster binding
I3J23_14605	COG0668	transmembrane transport
I3J23_14610	COG2719	SpoVR family
I3J23_14615	COG1785	Belongs to the alkaline phosphatase family
I3J23_14620	COG0791	NLP P60 protein
I3J23_14620	COG1388	LysM domain
I3J23_14625	COG0583	DNA-binding transcription factor activity
I3J23_14630	COG0372	Belongs to the citrate synthase family
I3J23_14635	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_14640	COG0531	amino acid
I3J23_14645	COG0733	neurotransmitter:sodium symporter activity
I3J23_14660	COG1595	DNA-templated transcription, initiation
I3J23_14665	COG0204	Acyl-transferase
I3J23_14670	COG1253	flavin adenine dinucleotide binding
I3J23_14675	COG0789	Transcriptional regulator
I3J23_14680	COG0436	Aminotransferase
I3J23_14685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J23_14690	COG1253	flavin adenine dinucleotide binding
I3J23_14695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J23_14700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I3J23_14705	COG0584	glycerophosphoryl diester phosphodiesterase
I3J23_14715	COG0668	transmembrane transport
I3J23_14720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3J23_14725	COG0726	polysaccharide deacetylase
I3J23_14730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3J23_14735	COG3226	Transcriptional regulator
I3J23_14745	COG0589	response to stress
I3J23_14750	COG1132	(ABC) transporter
I3J23_14755	COG1132	(ABC) transporter
I3J23_14760	COG0702	epimerase
I3J23_14775	COG0189	ligase activity
I3J23_14780	COG0189	ligase activity
I3J23_14795	COG4335	DNA alkylation repair
I3J23_14800	COG0561	phosphatase activity
I3J23_14805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I3J23_14815	COG0475	glutathione-regulated potassium exporter activity
I3J23_14820	COG0490	domain, Protein
I3J23_14830	COG1024	Enoyl-CoA hydratase
I3J23_14840	COG4152	abc transporter atp-binding protein
I3J23_14845	COG1668	transmembrane transport
I3J23_14850	COG0420	3'-5' exonuclease activity
I3J23_14855	COG4717	serine-type aminopeptidase activity
I3J23_14870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I3J23_14905	COG4980	gas vesicle protein
I3J23_14920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3J23_14925	COG0537	adenosine 5'-monophosphoramidase activity
I3J23_14930	COG1131	(ABC) transporter
I3J23_14935	COG4473	ABC transporter
I3J23_14945	COG1473	amidohydrolase
I3J23_14955	COG2329	Antibiotic biosynthesis monooxygenase
I3J23_14960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3J23_14970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I3J23_14975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I3J23_14980	COG1309	transcriptional regulator
I3J23_14985	COG1511	domain protein
I3J23_14990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J23_15000	COG1363	Peptidase, m42
I3J23_15005	COG1301	dicarboxylic acid transport
I3J23_15015	COG1234	tRNA 3'-trailer cleavage
I3J23_15020	COG0095	Lipoate-protein ligase
I3J23_15025	COG0702	epimerase
I3J23_15030	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_15040	COG0501	Belongs to the peptidase M48B family
I3J23_15045	COG1404	Belongs to the peptidase S8 family
I3J23_15050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I3J23_15055	COG0406	alpha-ribazole phosphatase activity
I3J23_15060	COG0183	Belongs to the thiolase family
I3J23_15065	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_15070	COG1268	BioY protein
I3J23_15075	COG0840	transmembrane signaling receptor activity
I3J23_15080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J23_15080	COG0723	plastoquinol--plastocyanin reductase activity
I3J23_15085	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_15095	COG4903	ComK protein
I3J23_15105	COG5646	InterPro IPR014922
I3J23_15125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3J23_15140	COG0398	Pfam SNARE associated Golgi protein
I3J23_15145	COG0681	Belongs to the peptidase S26 family
I3J23_15150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I3J23_15155	COG1846	Transcriptional regulator
I3J23_15160	COG3180	Ammonia monooxygenase
I3J23_15165	COG2814	Major facilitator Superfamily
I3J23_15175	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I3J23_15180	COG2323	membrane
I3J23_15195	COG0420	3'-5' exonuclease activity
I3J23_15200	COG0419	ATPase involved in DNA repair
I3J23_15205	COG1403	HNH endonuclease
I3J23_15245	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3J23_15260	COG0367	asparagine synthase
I3J23_15265	COG1562	ergosterol biosynthetic process
I3J23_15270	COG0534	Mate efflux family protein
I3J23_15275	COG1917	Cupin 2, conserved barrel domain protein
I3J23_15275	COG2207	Transcriptional regulator
I3J23_15280	COG1609	Transcriptional regulator
I3J23_15285	COG0673	inositol 2-dehydrogenase activity
I3J23_15290	COG2318	DinB family
I3J23_15295	COG1357	PFAM Pentapeptide repeats (8 copies)
I3J23_15300	COG2153	protein acetylation
I3J23_15305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3J23_15305	COG0646	methionine synthase
I3J23_15315	COG2996	Protein conserved in bacteria
I3J23_15320	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J23_15325	COG0840	transmembrane signaling receptor activity
I3J23_15335	COG1307	EDD domain protein, DegV family
I3J23_15340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I3J23_15360	COG0561	phosphatase activity
I3J23_15365	COG1073	alpha beta
I3J23_15370	COG2151	metal-sulfur cluster biosynthetic enzyme
I3J23_15380	COG0277	FAD linked oxidase domain protein
I3J23_15385	COG2271	Major facilitator Superfamily
I3J23_15395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I3J23_15405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I3J23_15410	COG0505	Belongs to the CarA family
I3J23_15415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J23_15420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I3J23_15435	COG2267	carboxylic ester hydrolase activity
I3J23_15445	COG1744	ABC transporter substrate-binding protein PnrA-like
I3J23_15460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I3J23_15465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I3J23_15470	COG5504	Zn-dependent protease
I3J23_15475	COG0444	Belongs to the ABC transporter superfamily
I3J23_15480	COG4608	Belongs to the ABC transporter superfamily
I3J23_15490	COG0601	transmembrane transport
I3J23_15495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J23_15515	COG0180	Tryptophanyl-tRNA synthetase
I3J23_15520	COG4166	transmembrane transport
I3J23_15525	COG0601	transmembrane transport
I3J23_15530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J23_15535	COG0444	Belongs to the ABC transporter superfamily
I3J23_15540	COG4608	Belongs to the ABC transporter superfamily
I3J23_15550	COG0456	acetyltransferase
I3J23_15555	COG1393	Belongs to the ArsC family
I3J23_15560	COG0861	Integral membrane protein TerC family
I3J23_15570	COG4862	establishment of competence for transformation
I3J23_15575	COG4469	Competence protein
I3J23_15580	COG1164	Oligoendopeptidase f
I3J23_15590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I3J23_15595	COG2346	COG2346, Truncated hemoglobins
I3J23_15600	COG0741	lytic transglycosylase activity
I3J23_15605	COG4116	CYTH
I3J23_15615	COG2357	RelA SpoT domain protein
I3J23_15620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I3J23_15625	COG0564	pseudouridine synthase activity
I3J23_15635	COG0569	domain protein
I3J23_15635	COG0475	glutathione-regulated potassium exporter activity
I3J23_15640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I3J23_15645	COG0352	thiamine-phosphate diphosphorylase activity
I3J23_15650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I3J23_15655	COG2104	thiamine diphosphate biosynthetic process
I3J23_15665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3J23_15670	COG0351	phosphomethylpyrimidine kinase
I3J23_15675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I3J23_15730	COG0210	DNA helicase
I3J23_15750	COG1131	(ABC) transporter
I3J23_15760	COG2153	protein acetylation
I3J23_15770	COG2382	esterase
I3J23_15775	COG0626	cystathionine gamma-synthase activity
I3J23_15780	COG0626	cystathionine gamma-synthase activity
I3J23_15795	COG5444	nuclease activity
I3J23_15805	COG0346	lactoylglutathione lyase activity
I3J23_15810	COG2367	Beta-lactamase
I3J23_15815	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I3J23_15825	COG1846	Transcriptional regulator
I3J23_15835	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I3J23_15840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3J23_15845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3J23_15850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_15850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I3J23_15855	COG1447	Phosphotransferase system cellobiose-specific component IIA
I3J23_15865	COG1349	DNA-binding transcription factor activity
I3J23_15885	COG1285	pathogenesis
I3J23_15900	COG2205	protein histidine kinase activity
I3J23_15910	COG3383	formate dehydrogenase (NAD+) activity
I3J23_15915	COG2427	Protein of unknown function (DUF1641)
I3J23_15920	COG2124	cytochrome p450
I3J23_15925	COG1819	glycosyl
I3J23_15935	COG1587	Uroporphyrinogen-III synthase
I3J23_15940	COG0390	transport system, permease component
I3J23_15945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I3J23_15950	COG0697	spore germination
I3J23_15955	COG4297	protein containing double-stranded beta helix domain
I3J23_15965	COG1252	NADH dehydrogenase
I3J23_15975	COG2211	Major facilitator Superfamily
I3J23_15980	COG1609	Transcriptional regulator
I3J23_15985	COG0246	Mannitol dehydrogenase
I3J23_15990	COG2721	sulfolactate sulfo-lyase activity
I3J23_15995	COG0730	response to heat
I3J23_16000	COG2318	DinB family
I3J23_16005	COG0457	Tetratricopeptide repeat
I3J23_16015	COG1388	LysM domain
I3J23_16015	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_16015	COG5632	N-Acetylmuramoyl-L-alanine amidase
I3J23_16025	COG4195	phage-related replication protein
I3J23_16030	COG2856	Zn peptidase
I3J23_16035	COG1396	sequence-specific DNA binding
I3J23_16045	COG1522	sequence-specific DNA binding
I3J23_16050	COG1484	DNA-dependent DNA replication
I3J23_16070	COG1595	DNA-templated transcription, initiation
I3J23_16075	COG3728	DNA packaging
I3J23_16075	COG5484	DNA packaging
I3J23_16080	COG1783	phage Terminase large subunit
I3J23_16085	COG5518	Phage portal protein
I3J23_16090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I3J23_16095	COG4653	Phage capsid family
I3J23_16145	COG3953	SLT domain
I3J23_16145	COG5412	phage tail tape measure protein
I3J23_16145	COG3953	SLT domain
I3J23_16145	COG3953	SLT domain
I3J23_16145	COG5412	phage tail tape measure protein
I3J23_16145	COG5412	phage tail tape measure protein
I3J23_16150	COG1652	LysM domain
I3J23_16155	COG4193	domain, Protein
I3J23_16165	COG3628	GPW Gp25 family protein
I3J23_16170	COG3299	homolog of phage Mu protein gp47
I3J23_16175	COG3778	Protein conserved in bacteria
I3J23_16215	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_16215	COG5632	N-Acetylmuramoyl-L-alanine amidase
I3J23_16230	COG0306	phosphate transporter
I3J23_16235	COG1392	Phosphate transport regulator
I3J23_16240	COG0531	amino acid
I3J23_16245	COG0346	lactoylglutathione lyase activity
I3J23_16250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I3J23_16255	COG0463	Glycosyl transferase, family 2
I3J23_16265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I3J23_16270	COG0477	Major facilitator Superfamily
I3J23_16275	COG2362	D-Aminopeptidase
I3J23_16280	COG0601	transmembrane transport
I3J23_16285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3J23_16290	COG0444	Belongs to the ABC transporter superfamily
I3J23_16295	COG4166	transmembrane transport
I3J23_16300	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J23_16305	COG4948	Mandelate Racemase Muconate Lactonizing
I3J23_16310	COG0791	NLP P60 protein
I3J23_16315	COG4608	Belongs to the ABC transporter superfamily
I3J23_16320	COG2706	6-phosphogluconolactonase activity
I3J23_16325	COG1834	amidinotransferase
I3J23_16330	COG1607	acyl-coa hydrolase
I3J23_16335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J23_16340	COG2076	Multidrug Resistance protein
I3J23_16345	COG2076	Multidrug Resistance protein
I3J23_16350	COG0788	formyltetrahydrofolate deformylase activity
I3J23_16355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J23_16365	COG1764	response to oxidative stress
I3J23_16370	COG1846	Transcriptional regulator
I3J23_16375	COG1764	response to oxidative stress
I3J23_16390	COG0463	Glycosyl transferase, family 2
I3J23_16390	COG0457	Tetratricopeptide repeat
I3J23_16400	COG2814	Major facilitator Superfamily
I3J23_16405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3J23_16415	COG1404	Belongs to the peptidase S8 family
I3J23_16420	COG1366	Belongs to the anti-sigma-factor antagonist family
I3J23_16425	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I3J23_16430	COG1122	ATPase activity
I3J23_16435	COG4721	ABC-type cobalt transport system, permease component
I3J23_16440	COG1388	LysM domain
I3J23_16440	COG3858	chitin binding
I3J23_16450	COG2239	Acts as a magnesium transporter
I3J23_16455	COG0789	Transcriptional regulator
I3J23_16470	COG1846	Transcriptional regulator
I3J23_16475	COG0726	polysaccharide deacetylase
I3J23_16480	COG3285	dna ligase
I3J23_16480	COG1793	dna ligase
I3J23_16485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I3J23_16490	COG0586	Pfam SNARE associated Golgi protein
I3J23_16495	COG0861	Integral membrane protein TerC family
I3J23_16500	COG1191	sigma factor activity
I3J23_16525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3J23_16530	COG2323	membrane
I3J23_16540	COG3594	Acyltransferase
I3J23_16545	COG5002	protein histidine kinase activity
I3J23_16550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3J23_16565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3J23_16570	COG0436	Aminotransferase
I3J23_16600	COG3852	Histidine kinase
I3J23_16605	COG1846	Transcriptional regulator
I3J23_16610	COG1360	Flagellar Motor Protein
I3J23_16615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I3J23_16620	COG0542	response to heat
I3J23_16625	COG3949	Membrane
I3J23_16640	COG0720	synthase
I3J23_16645	COG0602	queuosine metabolic process
I3J23_16660	COG4873	Protein conserved in bacteria
I3J23_16670	COG3773	Cell wall hydrolase
I3J23_16675	COG2244	polysaccharide biosynthetic process
I3J23_16680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_16685	COG2217	Heavy metal translocating P-type atpase
I3J23_16690	COG0006	proline dipeptidase activity
I3J23_16695	COG1609	Transcriptional regulator
I3J23_16700	COG3711	transcriptional antiterminator
I3J23_16705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I3J23_16705	COG1263	PTS System
I3J23_16705	COG2190	(PTS) system
I3J23_16710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_16715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3J23_16725	COG1533	DNA photolyase activity
I3J23_16730	COG0840	transmembrane signaling receptor activity
I3J23_16735	COG2084	Dehydrogenase
I3J23_16740	COG2340	Cysteine-rich secretory protein family
I3J23_16745	COG0768	penicillin binding
I3J23_16750	COG4191	Histidine kinase
I3J23_16755	COG0436	Aminotransferase
I3J23_16765	COG0835	chemotaxis
I3J23_16765	COG0784	Response regulator, receiver
I3J23_16775	COG2814	Major facilitator Superfamily
I3J23_16780	COG1376	ErfK ybiS ycfS ynhG family protein
I3J23_16785	COG1408	metallophosphoesterase
I3J23_16790	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_16800	COG2200	EAL domain
I3J23_16805	COG4703	Protein of unknown function (DUF1797)
I3J23_16810	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I3J23_16820	COG0517	IMP dehydrogenase activity
I3J23_16825	COG0583	DNA-binding transcription factor activity
I3J23_16830	COG0716	FMN binding
I3J23_16840	COG0716	FMN binding
I3J23_16860	COG0668	transmembrane transport
I3J23_16865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_16885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3J23_16890	COG0303	'Molybdopterin
I3J23_16895	COG1763	Mo-molybdopterin cofactor biosynthetic process
I3J23_16900	COG0314	molybdopterin synthase activity
I3J23_16905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I3J23_16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I3J23_16920	COG1136	(ABC) transporter
I3J23_16925	COG0577	efflux transmembrane transporter activity
I3J23_16930	COG1349	DNA-binding transcription factor activity
I3J23_16935	COG1105	Belongs to the carbohydrate kinase PfkB family
I3J23_16940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3J23_16940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I3J23_16940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3J23_16945	COG0681	Belongs to the peptidase S26 family
I3J23_16955	COG0488	(ABC) transporter
I3J23_16960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3J23_16965	COG2309	aminopeptidase activity
I3J23_16975	COG1077	Cell shape determining protein MreB Mrl
I3J23_16980	COG2002	toxin-antitoxin pair type II binding
I3J23_16985	COG3852	Histidine kinase
I3J23_16990	COG2105	PFAM AIG2 family protein
I3J23_16990	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I3J23_16995	COG0569	domain protein
I3J23_17005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J23_17015	COG0561	phosphatase activity
I3J23_17020	COG0242	peptide deformylase activity
I3J23_17030	COG0497	DNA recombination
I3J23_17040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_17040	COG3321	synthase
I3J23_17040	COG4221	oxidoreductase activity
I3J23_17040	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_17045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_17045	COG0300	oxidoreductase activity
I3J23_17045	COG3321	synthase
I3J23_17045	COG4221	oxidoreductase activity
I3J23_17050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_17050	COG4221	oxidoreductase activity
I3J23_17050	COG3321	synthase
I3J23_17050	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_17055	COG4221	oxidoreductase activity
I3J23_17055	COG3321	synthase
I3J23_17055	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_17055	COG0300	oxidoreductase activity
I3J23_17060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_17060	COG3321	synthase
I3J23_17060	COG4221	oxidoreductase activity
I3J23_17060	COG0300	oxidoreductase activity
I3J23_17065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_17065	COG0300	oxidoreductase activity
I3J23_17065	COG3321	synthase
I3J23_17065	COG4221	oxidoreductase activity
I3J23_17070	COG4221	oxidoreductase activity
I3J23_17070	COG3321	synthase
I3J23_17070	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_17070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_17075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J23_17080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I3J23_17085	COG0022	dehydrogenase e1 component
I3J23_17090	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J23_17095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3J23_17100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_17115	COG1982	Orn Lys Arg decarboxylase major
I3J23_17135	COG0483	inositol monophosphate 1-phosphatase activity
I3J23_17145	COG3227	Zinc metalloprotease (Elastase)
I3J23_17170	COG1217	gtp-binding protein TYPA
I3J23_17180	COG4896	Protein conserved in bacteria
I3J23_17190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I3J23_17195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I3J23_17200	COG2066	Belongs to the glutaminase family
I3J23_17210	COG0772	Belongs to the SEDS family
I3J23_17215	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I3J23_17230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I3J23_17230	COG2010	Cytochrome c
I3J23_17235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I3J23_17240	COG1845	cytochrome c oxidase, subunit III
I3J23_17245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I3J23_17250	COG3336	cytochrome c oxidase
I3J23_17260	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I3J23_17265	COG2340	Cysteine-rich secretory protein family
I3J23_17280	COG3679	Belongs to the UPF0342 family
I3J23_17295	COG0742	ribosomal rna small subunit methyltransferase
I3J23_17305	COG3314	Sporulation integral membrane protein YlbJ
I3J23_17310	COG1752	Esterase of the alpha-beta hydrolase superfamily
I3J23_17315	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3J23_17325	COG1399	metal-binding, possibly nucleic acid-binding protein
I3J23_17345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I3J23_17365	COG4839	cell division protein FtsL
I3J23_17370	COG0768	penicillin binding
I3J23_17375	COG0768	penicillin binding
I3J23_17395	COG0772	Belongs to the SEDS family
I3J23_17410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I3J23_17415	COG0849	cell division
I3J23_17420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3J23_17425	COG4412	M6 family metalloprotease domain protein
I3J23_17425	COG1404	Belongs to the peptidase S8 family
I3J23_17435	COG1191	sigma factor activity
I3J23_17440	COG1191	sigma factor activity
I3J23_17445	COG1119	ATPase activity
I3J23_17450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3J23_17455	COG1873	PFAM PRC-barrel domain
I3J23_17460	COG1496	oxidoreductase activity
I3J23_17465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3J23_17475	COG0762	integral membrane protein
I3J23_17480	COG2302	S4 RNA-binding domain
I3J23_17485	COG3599	regulation of cell shape
I3J23_17490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I3J23_17495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3J23_17505	COG0564	pseudouridine synthase activity
I3J23_17515	COG2233	PERMEase
I3J23_17525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3J23_17530	COG0505	Belongs to the CarA family
I3J23_17535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I3J23_17550	COG0284	orotidine-5'-phosphate decarboxylase activity
I3J23_17555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I3J23_17565	COG0306	phosphate transporter
I3J23_17580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I3J23_17585	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I3J23_17590	COG1648	precorrin-2 dehydrogenase activity
I3J23_17600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3J23_17605	COG1561	YicC-like family, N-terminal region
I3J23_17615	COG0194	GDP metabolic process
I3J23_17625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3J23_17630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3J23_17635	COG0242	peptide deformylase activity
I3J23_17645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I3J23_17645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I3J23_17655	COG0631	protein serine/threonine phosphatase activity
I3J23_17660	COG0515	serine threonine protein kinase
I3J23_17660	COG2815	serine threonine protein kinase
I3J23_17670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3J23_17675	COG1564	THIamine pyrophosphokinase
I3J23_17690	COG1302	Protein conserved in bacteria
I3J23_17695	COG1461	Dihydroxyacetone kinase
I3J23_17700	COG1760	l-serine dehydratase
I3J23_17705	COG1760	l-serine dehydratase
I3J23_17710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I3J23_17725	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I3J23_17730	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_17745	COG1196	nuclear chromosome segregation
I3J23_17750	COG0552	protein localization to endoplasmic reticulum
I3J23_17765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I3J23_17775	COG1837	Belongs to the UPF0109 family
I3J23_17800	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I3J23_17815	COG2257	FlhB HrpN YscU SpaS Family
I3J23_17825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I3J23_17830	COG0758	DNA mediated transformation
I3J23_17835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3J23_17845	COG4974	Belongs to the 'phage' integrase family
I3J23_17865	COG1815	bacterial-type flagellum-dependent cell motility
I3J23_17870	COG1558	bacterial-type flagellum-dependent cell motility
I3J23_17875	COG1677	Flagellar hook-basal body complex protein FliE
I3J23_17880	COG1766	The M ring may be actively involved in energy transduction
I3J23_17885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3J23_17890	COG1317	bacterial-type flagellum organization
I3J23_17895	COG1157	protein secretion by the type III secretion system
I3J23_17900	COG2882	bacterial-type flagellum organization
I3J23_17905	COG3334	PFAM MgtE intracellular
I3J23_17910	COG3144	bacterial-type flagellum assembly
I3J23_17915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I3J23_17920	COG4786	Flagellar basal body rod
I3J23_17925	COG1582	Flagellar protein (FlbD)
I3J23_17930	COG1580	Controls the rotational direction of flagella during chemotaxis
I3J23_17935	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3J23_17940	COG1776	CheC inhibitor of MCP methylation
I3J23_17940	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I3J23_17945	COG2201	protein-glutamate methylesterase activity
I3J23_17950	COG3190	flagellar
I3J23_17955	COG1338	Plays a role in the flagellum-specific transport system
I3J23_17960	COG1987	bacterial-type flagellum assembly
I3J23_17965	COG1684	flagellar biosynthetic protein fliR
I3J23_17970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3J23_17975	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I3J23_17980	COG1419	protein localization to endoplasmic reticulum
I3J23_17985	COG0455	bacterial-type flagellum organization
I3J23_17990	COG2201	protein-glutamate methylesterase activity
I3J23_17995	COG2198	Histidine kinase
I3J23_17995	COG0643	Histidine kinase
I3J23_18000	COG0835	chemotaxis
I3J23_18005	COG1776	CheC inhibitor of MCP methylation
I3J23_18015	COG1191	sigma factor activity
I3J23_18045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I3J23_18050	COG4589	Belongs to the CDS family
I3J23_18060	COG0750	zinc metalloprotease
I3J23_18070	COG2176	DNA-directed DNA polymerase activity
I3J23_18080	COG0195	Participates in both transcription termination and antitermination
I3J23_18085	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I3J23_18090	COG1358	cellular component organization or biogenesis
I3J23_18100	COG1550	Protein conserved in bacteria
I3J23_18115	COG0196	riboflavin kinase activity
I3J23_18130	COG0726	polysaccharide deacetylase
I3J23_18135	COG0612	Peptidase, M16
I3J23_18140	COG1873	PFAM PRC-barrel domain
I3J23_18145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I3J23_18150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I3J23_18155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I3J23_18160	COG0527	aspartate kinase activity
I3J23_18170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3J23_18175	COG0740	serine-type endopeptidase activity
I3J23_18185	COG4980	gas vesicle protein
I3J23_18185	COG1674	ftsk spoiiie
I3J23_18190	COG2188	Transcriptional regulator
I3J23_18195	COG2814	Major facilitator Superfamily
I3J23_18200	COG1846	Transcriptional regulator
I3J23_18205	COG2409	Drug exporters of the RND superfamily
I3J23_18205	COG1033	growth of symbiont in host cell
I3J23_18210	COG0612	Peptidase, M16
I3J23_18215	COG0612	Peptidase, M16
I3J23_18220	COG0300	oxidoreductase activity
I3J23_18235	COG1426	Protein conserved in bacteria
I3J23_18240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3J23_18255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I3J23_18265	COG1692	metallophosphoesterase
I3J23_18270	COG2359	stage V sporulation protein S
I3J23_18290	COG4550	Control of competence regulator ComK, YlbF/YmcA
I3J23_18335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_18340	COG3425	synthase
I3J23_18345	COG1024	Enoyl-CoA hydratase
I3J23_18350	COG1024	Enoyl-CoA hydratase
I3J23_18355	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18355	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_18355	COG3321	synthase
I3J23_18355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_18355	COG0300	oxidoreductase activity
I3J23_18360	COG4221	oxidoreductase activity
I3J23_18360	COG3321	synthase
I3J23_18360	COG0300	oxidoreductase activity
I3J23_18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_18365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_18365	COG3321	synthase
I3J23_18365	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_18365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_18365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_18365	COG3321	synthase
I3J23_18365	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_18365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I3J23_18370	COG3321	synthase
I3J23_18370	COG4221	oxidoreductase activity
I3J23_18370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_18370	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I3J23_18375	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3J23_18375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I3J23_18375	COG3321	synthase
I3J23_18380	COG2124	cytochrome p450
I3J23_18385	COG3209	COG3209 Rhs family protein
I3J23_18390	COG3619	membrane
I3J23_18400	COG1404	Belongs to the peptidase S8 family
I3J23_18410	COG4195	phage-related replication protein
I3J23_18415	COG1764	response to oxidative stress
I3J23_18425	COG2076	Multidrug Resistance protein
I3J23_18465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J23_18470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3J23_18475	COG4112	unkown
I3J23_18480	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3J23_18485	COG0464	growth
I3J23_18490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3J23_18495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I3J23_18500	COG0789	Transcriptional regulator
I3J23_18505	COG0174	glutamine synthetase
I3J23_18515	COG2211	Major facilitator Superfamily
I3J23_18520	COG3507	Belongs to the glycosyl hydrolase 43 family
I3J23_18535	COG1070	Carbohydrate kinase
I3J23_18540	COG0574	Belongs to the PEP-utilizing enzyme family
I3J23_18540	COG3848	Pyruvate phosphate dikinase
I3J23_18560	COG2378	regulation of single-species biofilm formation
I3J23_18565	COG2318	DinB family
I3J23_18570	COG1064	alcohol dehydrogenase
I3J23_18600	COG3397	chitin binding
I3J23_18610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3J23_18625	COG5434	Belongs to the glycosyl hydrolase 28 family
I3J23_18630	COG0756	dUTP diphosphatase activity
I3J23_18635	COG4195	phage-related replication protein
I3J23_18670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I3J23_18680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I3J23_18700	COG0785	Cytochrome C biogenesis protein
I3J23_18705	COG2201	protein-glutamate methylesterase activity
I3J23_18710	COG4846	Membrane protein involved in cytochrome C biogenesis
I3J23_18720	COG0071	Belongs to the small heat shock protein (HSP20) family
I3J23_18735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I3J23_18740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I3J23_18760	COG0824	Thioesterase
I3J23_18770	COG4841	protein insertion into membrane
I3J23_18780	COG1832	CoA-binding protein
I3J23_18785	COG0187	DNA topoisomerase II activity
I3J23_18790	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3J23_18800	COG1115	amino acid carrier protein
I3J23_18810	COG1063	alcohol dehydrogenase
I3J23_18815	COG0800	Aldolase
I3J23_18820	COG1312	Catalyzes the dehydration of D-mannonate
I3J23_18825	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18830	COG1609	Transcriptional regulator
I3J23_18870	COG2205	protein histidine kinase activity
I3J23_18875	COG0745	RESPONSE REGULATOR receiver
I3J23_18885	COG3507	Belongs to the glycosyl hydrolase 43 family
I3J23_18910	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_18915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I3J23_18920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I3J23_18925	COG2610	gluconate transmembrane transporter activity
I3J23_18930	COG2124	cytochrome p450
I3J23_18950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3J23_18960	COG2246	polysaccharide biosynthetic process
I3J23_18965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I3J23_18970	COG0586	Pfam SNARE associated Golgi protein
I3J23_18975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3J23_18980	COG1024	Enoyl-CoA hydratase
I3J23_18985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I3J23_18990	COG0511	ligase activity, forming carbon-carbon bonds
I3J23_18995	COG0439	Biotin carboxylase
I3J23_19000	COG0318	PFAM AMP-dependent synthetase and ligase
I3J23_19005	COG1960	acyl-CoA dehydrogenase activity
I3J23_19010	COG1649	PFAM Uncharacterised BCR, COG1649
I3J23_19020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_19020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I3J23_19025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_19030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_19035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_19040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I3J23_19045	COG2027	D-alanyl-D-alanine carboxypeptidase
I3J23_19050	COG2017	converts alpha-aldose to the beta-anomer
I3J23_19055	COG0534	Mate efflux family protein
I3J23_19065	COG5444	nuclease activity
I3J23_19080	COG3409	Peptidoglycan-binding domain 1 protein
I3J23_19080	COG5632	N-Acetylmuramoyl-L-alanine amidase
I3J23_19085	COG4824	toxin secretion phage lysis holin
I3J23_19105	COG5434	Belongs to the glycosyl hydrolase 28 family
I3J23_19110	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3J23_19110	COG1388	LysM domain
I3J23_19180	COG4626	Terminase
I3J23_19180	COG1802	Transcriptional regulator
I3J23_19215	COG0582	viral genome integration into host DNA
I3J23_19220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I3J23_19225	COG1595	DNA-templated transcription, initiation
I3J23_19335	COG0582	viral genome integration into host DNA
I3J23_19340	COG0166	Belongs to the GPI family
I3J23_19345	COG0405	Gamma-glutamyltransferase
I3J23_19350	COG2814	Major facilitator Superfamily
I3J23_19355	COG0640	Transcriptional regulator
I3J23_19370	COG0604	alcohol dehydrogenase
I3J23_19375	COG0493	'glutamate synthase
I3J23_19380	COG0070	glutamate synthase
I3J23_19380	COG0067	glutamate synthase
I3J23_19380	COG0069	glutamate synthase activity
I3J23_19385	COG0583	DNA-binding transcription factor activity
I3J23_19390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I3J23_19405	COG0300	oxidoreductase activity
I3J23_19410	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I3J23_19420	COG2814	Major facilitator Superfamily
I3J23_19425	COG1070	Carbohydrate kinase
I3J23_19430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3J23_19435	COG0243	molybdopterin cofactor binding
I3J23_19455	COG1028	Short-chain dehydrogenase reductase Sdr
I3J23_19460	COG1733	regulation of RNA biosynthetic process
I3J23_19465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I3J23_19470	COG0662	Cupin 2, conserved barrel domain protein
I3J23_19470	COG2207	Transcriptional regulator
I3J23_19475	COG1309	transcriptional regulator
I3J23_19480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_19490	COG0640	Transcriptional regulator
I3J23_19495	COG0741	lytic transglycosylase activity
I3J23_19500	COG2322	membrane
I3J23_19515	COG1619	proteins homologs of microcin C7 resistance protein MccF
I3J23_19525	COG1388	LysM domain
I3J23_19525	COG3584	3D domain protein
I3J23_19530	COG0514	ATP-dependent DNA helicase (RecQ)
I3J23_19540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I3J23_19545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I3J23_19560	COG0071	Belongs to the small heat shock protein (HSP20) family
I3J23_19590	COG1012	belongs to the aldehyde dehydrogenase family
I3J23_19595	COG1657	PFAM Prenyltransferase squalene oxidase
I3J23_19600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I3J23_19605	COG0733	neurotransmitter:sodium symporter activity
I3J23_19610	COG0385	Bile acid
I3J23_19615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I3J23_19620	COG0508	dehydrogenase complex catalyzes the overall conversion of
I3J23_19630	COG4548	von Willebrand factor, type A
I3J23_19635	COG0714	Associated with various cellular activities
I3J23_19640	COG2032	superoxide dismutase activity
I3J23_19645	COG0791	NLP P60 protein
I3J23_19645	COG1388	LysM domain