locus-tag class description FOG69_00010 ENOG4108Z0C Uvrb UvrC protein FOG69_00015 ENOG41066A3 ATP guanido phosphotransferase FOG69_00025 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOG69_00030 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FOG69_00035 ENOG4105CTP PilT protein domain protein FOG69_00040 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOG69_00045 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOG69_00050 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOG69_00055 ENOG4105D7W serine acetyltransferase FOG69_00065 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FOG69_00070 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOG69_00075 ENOG4105M0M Tetracycline resistance protein FOG69_00095 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOG69_00100 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOG69_00110 ENOG4108VZM 50s ribosomal protein L10 FOG69_00115 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOG69_00120 ENOG4107Y49 methyltransferase FOG69_00125 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOG69_00130 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOG69_00135 ENOG4105XPM ribosomal protein FOG69_00140 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOG69_00145 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOG69_00150 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOG69_00155 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOG69_00160 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOG69_00165 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOG69_00170 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOG69_00175 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOG69_00180 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOG69_00185 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOG69_00190 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOG69_00195 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOG69_00200 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOG69_00205 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOG69_00210 ENOG41082SA 50s ribosomal protein l29 FOG69_00215 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOG69_00220 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOG69_00230 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOG69_00240 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOG69_00245 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOG69_00250 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOG69_00255 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOG69_00260 ENOG4105VPB 50S ribosomal protein L30 FOG69_00265 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOG69_00270 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOG69_00275 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOG69_00280 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOG69_00290 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOG69_00300 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOG69_00305 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOG69_00310 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOG69_00315 ENOG4108ZT0 50S ribosomal protein l17 FOG69_00320 ENOG4108JJB ABC transporter FOG69_00325 ENOG4108JJB ABC transporter FOG69_00330 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOG69_00335 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOG69_00340 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOG69_00345 ENOG4108UJD 30S ribosomal protein S9 FOG69_00350 ENOG4108I0C methyltransferase FOG69_00365 ENOG4105D1F ATP-binding protein FOG69_00380 ENOG4108NMV polysaccharide deacetylase FOG69_00445 ENOG4108JPW Aminotransferase FOG69_00455 ENOG4105CPQ Dehydrogenase FOG69_00460 ENOG4105CHH sulfate transporter FOG69_00470 ENOG4108SA1 esterase FOG69_00490 ENOG410874W AraC family transcriptional regulator FOG69_00495 ENOG4105EHZ conserved protein UCP016719 FOG69_00500 ENOG4105D17 glycoside hydrolase, family 3 domain protein FOG69_00515 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOG69_00525 ENOG4105EWC Purine nucleoside phosphorylase FOG69_00555 ENOG4105EMN RNA polymerase sigma factor FOG69_00565 ENOG4105C8B TIGR00159 family FOG69_00570 ENOG4107U5W ybbr family FOG69_00575 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOG69_00610 ENOG4106K80 FOG69_00620 ENOG41067MG lrgb family FOG69_00630 ENOG41061AU MarR family Transcriptional regulator FOG69_00645 ENOG4105BZU Histidine kinase FOG69_00650 ENOG4105WH1 Two component transcriptional regulator luxr family FOG69_00655 ENOG4105CJ1 ABC, transporter FOG69_00665 ENOG41090VJ ABC-2 type transporter FOG69_00680 ENOG4106DDH Sporulation-specific SASP protein FOG69_00695 ENOG4107QTZ amino acid FOG69_00710 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOG69_00715 ENOG4105CXY transporter FOG69_00745 ENOG4107SCQ Iron-containing alcohol dehydrogenase FOG69_00750 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOG69_00755 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOG69_00760 ENOG4107ZTW SNARE associated Golgi FOG69_00775 ENOG4105C72 UPF0176 protein FOG69_00790 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOG69_00795 ENOG4108IQI permease FOG69_00800 ENOG4108J5H Homocysteine s-methyltransferase FOG69_00810 ENOG4105CSV Glutaminase FOG69_00835 ENOG41076HS cation diffusion facilitator family transporter FOG69_00840 ENOG4108TVJ Nitroreductase FOG69_00845 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOG69_00850 ENOG4108VGI doxx family FOG69_00855 ENOG4105XXY Thioredoxin FOG69_00875 ENOG4105DGI Alkaline phosphatase FOG69_00880 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOG69_00885 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOG69_00890 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FOG69_00895 ENOG4107EPV Aminotransferase class V FOG69_00900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOG69_00905 ENOG4105J7D transcriptional regulator FOG69_00910 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FOG69_00915 ENOG41060AI SEC-C motif FOG69_00920 ENOG4107SET aldo keto reductase FOG69_00950 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOG69_00965 ENOG4105U3E Transcriptional regulator FOG69_00970 ENOG4105DSE periplasmic solute binding protein FOG69_00975 ENOG4105DIK (ABC) transporter FOG69_00985 ENOG4105DEN Luciferase family FOG69_00990 ENOG4108N0M stress protein FOG69_00995 ENOG4106FN3 tellurium resistance protein FOG69_01000 ENOG4106FN3 tellurium resistance protein FOG69_01005 ENOG4107TS3 membrane protein, TerC FOG69_01010 ENOG4108TTB tellurium resistance protein FOG69_01020 ENOG41079KZ Major Facilitator Superfamily FOG69_01025 ENOG4108IJ7 Glycine betaine FOG69_01030 ENOG4107SQ8 Glycine betaine FOG69_01060 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOG69_01090 ENOG4105EIG urea carboxylase-associated protein 1 FOG69_01095 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FOG69_01100 ENOG4108WBH protein TIM barrel FOG69_01105 ENOG4105DJB Major Facilitator Superfamily FOG69_01110 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOG69_01115 ENOG4105I82 acetyl xylan esterase FOG69_01120 ENOG410756H nucleotidyltransferase FOG69_01130 ENOG4105C26 Dehydrogenase FOG69_01140 ENOG4107YHD transcriptional regulator FOG69_01145 ENOG4105CAY ferredoxin--nadp reductase FOG69_01150 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOG69_01155 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOG69_01160 ENOG4108IFG nitrite reductase, (NAD(P)H) FOG69_01170 ENOG4105CKI cobalamin synthesis protein FOG69_01175 ENOG4105E2A Dehydrogenase FOG69_01180 ENOG4105HHM rdd domain containing protein FOG69_01190 ENOG4105CS2 ec 3.2.1.21 FOG69_01205 ENOG41080HJ 6-phospho 3-hexuloisomerase FOG69_01210 ENOG4108VA3 3-hexulose-6-phosphate synthase FOG69_01215 ENOG4105KVH Transcriptional regulator FOG69_01220 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_01240 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOG69_01255 ENOG4105CDA abc transporter atp-binding protein FOG69_01260 ENOG4105DRP amino acid AbC transporter FOG69_01270 ENOG4106P55 Transcriptional regulator FOG69_01275 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOG69_01280 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOG69_01285 ENOG41069ZX FOG69_01290 ENOG41069ZX FOG69_01295 ENOG4105DUX Transporter FOG69_01310 ENOG4105E1K spore germination protein FOG69_01325 ENOG4105CPU Monooxygenase FOG69_01330 ENOG4108XSB acetyltransferase, (GNAT) family FOG69_01335 ENOG4105EAB amino acid AbC transporter FOG69_01340 ENOG4108HW4 amino acid AbC transporter FOG69_01350 ENOG4105CH2 amidohydrolase FOG69_01355 ENOG4108PGP mmge prpd family protein FOG69_01365 ENOG4107WD8 ABC transporter, permease FOG69_01370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_01375 ENOG4105BZU Histidine kinase FOG69_01395 ENOG4105CFH Aspartokinase FOG69_01400 ENOG4105DHS permease protein FOG69_01405 ENOG4105CM4 permease protein FOG69_01410 ENOG4108IPW abc transporter atp-binding protein FOG69_01425 ENOG4105R8C Transcriptional regulator FOG69_01430 ENOG4108DBC nitroreductase FOG69_01435 ENOG41067V3 Antibiotic biosynthesis monooxygenase FOG69_01440 ENOG4105YVS arsR family transcriptional regulator FOG69_01450 ENOG4108JPW Aminotransferase FOG69_01455 ENOG4105C26 Dehydrogenase FOG69_01465 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOG69_01470 ENOG4105KTB nuclear export factor GLE1 FOG69_01475 ENOG4108T5E Copper resistance protein FOG69_01480 ENOG4108ZYE Transcriptional regulator FOG69_01500 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FOG69_01520 ENOG4105E7W lamb ycsf family protein FOG69_01525 ENOG4105C5A transporter FOG69_01530 ENOG4105CFM UPF0317 protein FOG69_01535 ENOG4105P4J Allophanate hydrolase, subunit 1 FOG69_01545 ENOG4107258 Transcriptional regulator FOG69_01550 ENOG4105XJB lipolytic protein G-D-S-L family FOG69_01560 ENOG41061CK Antibiotic biosynthesis monooxygenase FOG69_01565 ENOG4107RVG penicillin-binding protein FOG69_01570 ENOG4107QM2 Aldo Keto reductase FOG69_01575 ENOG4105ETD TRANSCRIPTIONal FOG69_01590 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOG69_01605 ENOG410606W general stress protein FOG69_01615 ENOG4105VCH membrane FOG69_01625 ENOG4105C9U ATP-dependent DNA helicase RecQ FOG69_01640 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOG69_01655 ENOG4105C0X amino acid FOG69_01670 ENOG41068KG domain protein FOG69_01675 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOG69_01710 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOG69_01720 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) FOG69_01725 ENOG4105RXJ FOG69_01730 ENOG4105KPY Small multidrug resistance protein FOG69_01735 ENOG4105EU9 FOG69_01740 ENOG4105QVS general stress protein FOG69_01745 ENOG41082W1 Cupin 2, conserved barrel domain protein FOG69_01760 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOG69_01765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOG69_01770 ENOG4108MRH transcriptional regulatory protein FOG69_01775 ENOG4107QJT sodium dicarboxylate symporter FOG69_01780 ENOG4106F5Q Membrane FOG69_01785 ENOG4105CJ1 ABC, transporter FOG69_01800 ENOG4105FDT acyl-CoA dehydrogenase FOG69_01825 ENOG4105SZ6 Thioredoxin FOG69_01830 ENOG4105CPF Cell wall formation (By similarity) FOG69_01835 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOG69_01840 ENOG4105C1J atp-dependent rna helicase FOG69_01845 ENOG410905X membrane-flanked domain protein FOG69_01850 ENOG4105CKV Membrane FOG69_01860 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOG69_01865 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOG69_01870 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOG69_01880 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOG69_01885 ENOG4107MMM Anti-sigma-factor antagonist FOG69_01890 ENOG4105FUA antagonist FOG69_01895 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FOG69_01900 ENOG4107SGM protein serine threonine phosphatase FOG69_01905 ENOG4105WN5 stage II sporulation protein FOG69_01910 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FOG69_01920 ENOG41064BQ Phosphatase FOG69_01935 ENOG410906U SprT-like FOG69_01985 ENOG4105K56 Transcriptional regulator FOG69_01995 ENOG410645S MarR family Transcriptional regulator FOG69_02000 ENOG4105DCM major facilitator superfamily FOG69_02005 ENOG4105D3P Mannan endo-1,4-beta-mannosidase FOG69_02010 ENOG4106128 DNA-binding helix-turn-helix protein FOG69_02030 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOG69_02040 ENOG4105VEQ Cold shock protein FOG69_02060 ENOG4107U9B transcriptional regulator FOG69_02065 ENOG4105DXI Major Facilitator superfamily FOG69_02070 ENOG4105IRW patatin-like phospholipase family protein FOG69_02080 ENOG4105DNP FAD linked oxidase domain protein FOG69_02090 ENOG4105PGM cation diffusion facilitator family transporter FOG69_02100 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOG69_02105 ENOG4108U7W acetyltransferase FOG69_02110 ENOG41086D8 Transcriptional regulator FOG69_02135 ENOG4105DQ4 alcohol dehydrogenase FOG69_02140 ENOG4105VUF Transcriptional regulator FOG69_02150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOG69_02160 ENOG4105EQ0 Major Facilitator superfamily FOG69_02165 ENOG4108JGH Tetr family transcriptional regulator FOG69_02170 ENOG4105T38 integral membrane protein FOG69_02175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOG69_02190 ENOG4105E2A Dehydrogenase FOG69_02195 ENOG4105PGS Spore coat protein FOG69_02205 ENOG4105EYF MMPL domain protein FOG69_02225 ENOG4108JYZ YitT family FOG69_02235 ENOG4105C2C drug resistance transporter, Bcr CflA FOG69_02240 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOG69_02260 ENOG41090E6 transcriptional regulator MERR family FOG69_02275 ENOG4105EBM Alpha Beta Hydrolase Fold protein FOG69_02280 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOG69_02285 ENOG4105DRR Transcriptional regulator, GntR family FOG69_02300 ENOG4105FQP Beta-lactamase FOG69_02305 ENOG41090UD (LipO)protein FOG69_02310 ENOG4108SUT Major Facilitator Superfamily FOG69_02315 ENOG4108TZY GntR Family Transcriptional Regulator FOG69_02320 ENOG4105JXH GntR family transcriptional regulator FOG69_02325 ENOG4105DJ2 Major Facilitator Superfamily FOG69_02345 ENOG4107QTZ amino acid FOG69_02365 ENOG4107QNK )-transporter FOG69_02405 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FOG69_02410 ENOG4105K8N protein family UPF0079, ATPase FOG69_02415 ENOG41072GX Peptidase M22 Glycoprotease FOG69_02420 ENOG410801F ribosomal-protein-alanine acetyltransferase FOG69_02425 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOG69_02430 ENOG4105C5H ABC transporter FOG69_02435 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOG69_02440 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FOG69_02445 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOG69_02450 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOG69_02460 ENOG4108TYN CAAX amino terminal protease family protein FOG69_02465 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOG69_02470 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOG69_02475 ENOG4105ESF Peptidoglycan binding domain protein FOG69_02490 ENOG4105PGZ NB-ARC domain FOG69_02495 ENOG4105CPQ Dehydrogenase FOG69_02515 ENOG41087YS Phage shock protein A FOG69_02520 ENOG4105DQX Zinc finger domain FOG69_02525 ENOG4108WV1 Pfam:DUF477 FOG69_02535 ENOG4105EXC Acyl-transferase FOG69_02540 ENOG4108P49 AntiSigma factor FOG69_02545 ENOG4105JVQ RNA Polymerase FOG69_02570 ENOG4107STQ Multicopper oxidase FOG69_02575 ENOG4105C85 amino acid FOG69_02590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOG69_02605 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOG69_02620 ENOG4105C7N Xanthine uracil vitamin C permease FOG69_02645 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOG69_02650 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOG69_02655 ENOG4105C83 adenylosuccinate lyase FOG69_02660 ENOG4105C8V SAICAR synthetase FOG69_02665 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOG69_02670 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I FOG69_02675 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FOG69_02685 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOG69_02690 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOG69_02695 ENOG4105DC1 bifunctional purine biosynthesis protein purh FOG69_02700 ENOG4105C12 Phosphoribosylglycinamide synthetase FOG69_02710 ENOG4105DVH amino acid FOG69_02725 ENOG4108R5T secreted protein FOG69_02730 ENOG4105KGF protein, YerC YecD FOG69_02735 ENOG4105CBC glutamate synthase FOG69_02745 ENOG4105C4R Atp-dependent dna helicase FOG69_02750 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOG69_02760 ENOG4105CRN Aminoglycoside phosphotransferase FOG69_02765 ENOG4105KT7 mgtC SapB transporter FOG69_02770 ENOG4105CK7 Sodium proline symporter FOG69_02775 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOG69_02780 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOG69_02785 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOG69_02790 ENOG4108IG5 Transcriptional regulator FOG69_02800 ENOG4105CBD Diacylglycerol kinase FOG69_02805 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOG69_02820 ENOG4105CJ1 ABC, transporter FOG69_02855 ENOG4106BHF FOG69_02860 ENOG4105CDY transcriptional regulatory protein FOG69_02870 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOG69_02885 ENOG4105WEF catalase FOG69_02890 ENOG4105M18 -acetyltransferase FOG69_02900 ENOG4105H67 Protein of unknown function (DUF421) FOG69_02905 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOG69_02910 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOG69_02930 ENOG4106I4J membrane FOG69_02935 ENOG41082F9 transcriptional regulator FOG69_02940 ENOG41061H0 Monooxygenase FOG69_02945 ENOG4108R1P FOG69_02950 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOG69_02960 ENOG4105E0M Sulfatase FOG69_02965 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOG69_02975 ENOG41090R9 glycosyltransferase FOG69_02980 ENOG4107R51 Glycosyl transferase, family 2 FOG69_02985 ENOG41090R9 glycosyltransferase FOG69_02990 ENOG4105EU0 Major facilitator Superfamily FOG69_02995 ENOG4105CUB amino acid FOG69_03000 ENOG4105C26 Dehydrogenase FOG69_03005 ENOG4105FKZ Methyl-accepting chemotaxis FOG69_03010 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOG69_03015 ENOG4107TVC Glycosyl transferase, family 2 FOG69_03020 ENOG4105C5H ABC transporter FOG69_03025 ENOG4107SWG transcriptional regulator MERR family FOG69_03030 ENOG4105DXB Major Facilitator superfamily FOG69_03035 ENOG4105C5H ABC transporter FOG69_03040 ENOG4105FDU atp-dependent rna helicase FOG69_03045 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOG69_03060 ENOG4108J20 pectate lyase FOG69_03065 ENOG4107QPK )-transporter FOG69_03090 ENOG4108NEV two component transcriptional regulator, LytTR family FOG69_03100 ENOG4108Z6X (sortase) family FOG69_03110 ENOG4108MRH transcriptional regulatory protein FOG69_03135 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) FOG69_03140 ENOG4108RPX mosc domain containing protein FOG69_03155 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOG69_03195 ENOG4105C5Y PTS System FOG69_03200 ENOG4105CG3 alpha amylase, catalytic region FOG69_03205 ENOG4107414 GntR family transcriptional regulator FOG69_03210 ENOG4108RCM Nitroreductase FOG69_03225 ENOG4105CGH 5'-nucleotidase FOG69_03230 ENOG4107RKG DJ-1/PfpI family FOG69_03235 ENOG4105ETE Transcriptional regulator (LacI family FOG69_03240 ENOG4105E2X shikimate dehydrogenase FOG69_03245 ENOG4105FF2 Type I DHQase FOG69_03260 ENOG4105KJF protein tyrosine phosphatase FOG69_03270 ENOG4107U9T Pfam:Ribonuclease_BN FOG69_03280 ENOG4108ISG Major Facilitator FOG69_03285 ENOG4105UPD Calcium Proton FOG69_03295 ENOG4105D8X mechanosensitive ion channel FOG69_03315 ENOG4106KE4 Dehydrogenase FOG69_03325 ENOG4105D7N magnesium and cobalt transport protein CorA FOG69_03335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOG69_03350 ENOG4105BZ1 (ABC) transporter FOG69_03355 ENOG4105CJA serine threonine protein kinase FOG69_03375 ENOG4107RUY (E1 component), alpha subunit FOG69_03385 ENOG4107QKR Dehydrogenase FOG69_03395 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOG69_03405 ENOG4105F8D glycoside hydrolase family 4 FOG69_03410 ENOG4108Q3X Transcriptional regulator FOG69_03415 ENOG4105CI1 PTS System FOG69_03425 ENOG4105BZ1 (ABC) transporter FOG69_03430 ENOG4105BZ1 (ABC) transporter FOG69_03440 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOG69_03450 ENOG4105U3E Transcriptional regulator FOG69_03455 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOG69_03460 ENOG4105H93 Acyltransferase family FOG69_03470 ENOG4108YYS metal-dependent hydrolase (By similarity) FOG69_03475 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOG69_03480 ENOG410834F Transcriptional regulator FOG69_03490 ENOG4105JAB phenazine biosynthesis protein, phzf family FOG69_03495 ENOG4107Y03 Nitroreductase FOG69_03510 ENOG4105ECP epimerase FOG69_03515 ENOG410902V Modulates RecA activity (By similarity) FOG69_03525 ENOG4105F27 Major Facilitator FOG69_03535 ENOG4108TCS Glutamyl endopeptidase FOG69_03555 ENOG4106AKJ FOG69_03560 ENOG4105D74 hydrolase FOG69_03565 ENOG4105CKK Glycosyl transferase, family 2 FOG69_03570 ENOG4105EJV Membrane FOG69_03575 ENOG41067AE Membrane-bound metal-dependent hydrolase FOG69_03580 ENOG4105CEN a g-specific adenine glycosylase FOG69_03585 ENOG4106BXE FOG69_03590 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FOG69_03610 ENOG4105BZ1 (ABC) transporter FOG69_03615 ENOG4107NBY Membrane FOG69_03620 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOG69_03625 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOG69_03630 ENOG4105G5W regulator Fur family FOG69_03635 ENOG4105TUA UPF0295 protein FOG69_03740 ENOG4107S6Z Na H antiporter FOG69_03745 ENOG4105EC3 peptidase S51, dipeptidase E FOG69_03750 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FOG69_03755 ENOG4105DNP FAD linked oxidase domain protein FOG69_03765 ENOG4105DEF Extracellular solute-binding protein, family 5 FOG69_03775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOG69_03780 ENOG4105C3U ABC transporter FOG69_03800 ENOG4105E2Y ABC, transporter FOG69_03805 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOG69_03810 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOG69_03830 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOG69_03835 ENOG4107D63 FOG69_03840 ENOG4105VZ8 Transcriptional regulator FOG69_03855 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOG69_03865 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOG69_03885 ENOG4105CYN Serine protein kinase FOG69_03895 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOG69_03900 ENOG4105CW7 secretion protein, HlyD family FOG69_03905 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOG69_03910 ENOG4105CS1 NAD(P)H quinone oxidoreductase FOG69_03925 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOG69_03930 ENOG4105CZV ABC transporter FOG69_03935 ENOG4105CJ1 ABC, transporter FOG69_03940 ENOG4108TU7 Inherit from COG: (ABC) transporter FOG69_03945 ENOG4105VEQ Cold shock protein FOG69_03955 ENOG4105BZU Histidine kinase FOG69_03965 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOG69_04000 ENOG4108YBP pseudouridine synthase FOG69_04010 ENOG41080XP Cbs domain FOG69_04015 ENOG4107YBY Hydrolase FOG69_04020 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOG69_04025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOG69_04030 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOG69_04040 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOG69_04045 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOG69_04055 ENOG4105BZU Histidine kinase FOG69_04060 ENOG4105WH1 Two component transcriptional regulator luxr family FOG69_04095 ENOG4105ED1 spovr family FOG69_04100 ENOG4105G6Z alkaline phosphatase FOG69_04115 ENOG4105BZN citrate synthase FOG69_04120 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOG69_04125 ENOG4105CUB amino acid FOG69_04130 ENOG4105C8J )-transporter FOG69_04140 ENOG4105J37 FOG69_04145 ENOG4108AEY RNA polymerase sigma factor FOG69_04150 ENOG4105F6E Acyl-transferase FOG69_04155 ENOG4105C37 (CBS) domain FOG69_04165 ENOG4105CHM Aminotransferase FOG69_04170 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase FOG69_04175 ENOG4105C37 (CBS) domain FOG69_04185 ENOG4105WMR Protein CrcB homolog FOG69_04190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOG69_04200 ENOG4105D64 Mechanosensitive ion channel FOG69_04205 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOG69_04210 ENOG4107VMI polysaccharide deacetylase FOG69_04215 ENOG4105F0I Aminotransferase FOG69_04220 ENOG4105W1N transcriptional regulator FOG69_04225 ENOG4105IIP Membrane FOG69_04235 ENOG4105BZ1 (ABC) transporter FOG69_04240 ENOG4105BZ1 (ABC) transporter FOG69_04260 ENOG410839P FOG69_04270 ENOG4106MP8 UPF0754 membrane protein FOG69_04275 ENOG4105WZB UPF0342 protein FOG69_04285 ENOG4105D4P Coproporphyrinogen iii oxidase FOG69_04295 ENOG4107S91 Sodium hydrogen exchanger FOG69_04300 ENOG4105NCW Trka-c domain protein FOG69_04310 ENOG4105CGU Enoyl-CoA hydratase FOG69_04320 ENOG4108IUX (ABC) transporter FOG69_04325 ENOG4105RHA ABC transporter, permease FOG69_04330 ENOG4107VRP DNA repair exonuclease FOG69_04335 ENOG4106D4I domain protein FOG69_04340 ENOG4105EQI Metal Dependent Phosphohydrolase FOG69_04350 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOG69_04400 ENOG4105NBU tryptophan transport protein FOG69_04405 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOG69_04410 ENOG4105K59 histidine triad (HIT) protein FOG69_04440 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOG69_04445 ENOG4105BZ4 penicillin-binding protein FOG69_04450 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOG69_04455 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOG69_04460 ENOG4105C1Q protoporphyrinogen oxidase FOG69_04470 ENOG4105ECB domain protein FOG69_04485 ENOG4105DER m42 family FOG69_04495 ENOG4106AXD FOG69_04500 ENOG4108RQ5 Beta-lactamase domain-containing protein FOG69_04505 ENOG4105DF9 Lipoate-protein, ligase FOG69_04515 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_04525 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOG69_04540 ENOG4108HUF Transporter FOG69_04545 ENOG4107TB6 phosphoglycerate mutase FOG69_04555 ENOG4107F3J Amp-dependent synthetase and ligase FOG69_04560 ENOG4107ZYJ bioY protein FOG69_04565 ENOG4106YBV Methyl-accepting chemotaxis FOG69_04585 ENOG4105XVF Competence transcription factor FOG69_04590 ENOG4108ZMX Domain of unknown function (DU1801) FOG69_04605 ENOG4105X3H Excalibur domain protein FOG69_04610 ENOG4105K8R UPF0145 protein FOG69_04615 ENOG4105E1V na solute symporter FOG69_04620 ENOG4106CAD Protein of unknown function (DUF3311) FOG69_04625 ENOG41060YP FOG69_04640 ENOG4107SCK Monooxygenase FOG69_04645 ENOG4108INS Transcriptional regulator FOG69_04650 ENOG4108KK1 membrane protein AbrB duplication FOG69_04660 ENOG4108IG5 Transcriptional regulator FOG69_04670 ENOG4108QY0 Membrane FOG69_04675 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOG69_04680 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOG69_04690 ENOG4105EYH Exonuclease FOG69_04735 ENOG4105ERH Fumarylacetoacetate hydrolase FOG69_04745 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOG69_04755 ENOG4105CAQ asparagine synthetase FOG69_04765 ENOG4105UQX Mate efflux family protein FOG69_04770 ENOG4106HBX Transcriptional Regulator AraC Family FOG69_04775 ENOG4105ETE Transcriptional regulator (LacI family FOG69_04780 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOG69_04785 ENOG4105SF0 DinB family FOG69_04790 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOG69_04795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOG69_04800 ENOG4105MYW Pentapeptide repeat protein FOG69_04805 ENOG4105MA6 gCN5-related N-acetyltransferase FOG69_04815 ENOG4108VPT UPF0234 protein FOG69_04820 ENOG4105QNR S1 RNA binding domain protein FOG69_04825 ENOG4105DIH basic membrane FOG69_04830 ENOG4105C8Q Methyl-accepting chemotaxis FOG69_04835 ENOG4107E6A Cytochrome p-450 FOG69_04845 ENOG4105EPR degv family FOG69_04850 ENOG4107AYK membrAne FOG69_04860 ENOG41073B9 FOG69_04865 ENOG4108KP7 hydrolase FOG69_04870 ENOG4108MXZ Esterase FOG69_04875 ENOG4105VG1 fes assembly suf system protein FOG69_04880 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOG69_04885 ENOG4105IQ5 FAD linked oxidase domain protein FOG69_04895 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOG69_04905 ENOG4105CAS nag kinase FOG69_04910 ENOG4105C8Y Acetylornithine aminotransferase FOG69_04915 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOG69_04925 ENOG4105DBV ornithine carbamoyltransferase FOG69_04955 ENOG4107RMD Basic membrane lipoprotein FOG69_04970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOG69_04975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOG69_04985 ENOG4105C3U ABC transporter FOG69_04990 ENOG4108JQ7 (ABC) transporter FOG69_05005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOG69_05015 ENOG4105C31 Tryptophanyl-tRNA synthetase FOG69_05025 ENOG4108J59 Extracellular solute-binding protein, family 5 FOG69_05030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOG69_05035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOG69_05045 ENOG4108JQ7 (ABC) transporter FOG69_05060 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FOG69_05065 ENOG4108ZCF integral membrane protein FOG69_05070 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FOG69_05080 ENOG4105DPN Oligoendopeptidase f FOG69_05085 ENOG4105T58 Dithiol-disulfide isomerase FOG69_05090 ENOG4108Z18 K06886 hemoglobin FOG69_05095 ENOG4105E4C Lytic transglycosylase catalytic FOG69_05100 ENOG4105MIX Adenylate cyclase FOG69_05115 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOG69_05120 ENOG4105EMS pseudouridine synthase FOG69_05125 ENOG4107S1Q Phosphatase FOG69_05135 ENOG4105ETU transcriptional activator (TenA FOG69_05140 ENOG4108VEU Thiamine monophosphate synthase FOG69_05160 ENOG4105D06 uba thif-type nad fad binding protein FOG69_05165 ENOG4105DWF phosphomethylpyrimidine kinase FOG69_05170 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOG69_05175 ENOG4107A88 FOG69_05225 ENOG4105ENA helicase FOG69_05245 ENOG4105CJ1 ABC, transporter FOG69_05260 ENOG4108ZMI UPF0477 protein FOG69_05270 ENOG4105C28 cystathionine FOG69_05275 ENOG4105C28 cystathionine FOG69_05285 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOG69_05290 ENOG410635T phage-like element pbsx protein FOG69_05300 ENOG4107Y9E nuclease FOG69_05305 ENOG41067QW Transcriptional regulator FOG69_05365 ENOG4105QBX endodeoxyribonuclease RusA FOG69_05440 ENOG4107KNS FOG69_05530 ENOG4108FKH Transglycosylase SLT domain FOG69_05570 ENOG41068G1 FOG69_05620 ENOG4106BHF FOG69_05650 ENOG4105VTR Integrase FOG69_05705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOG69_05765 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOG69_05785 ENOG4105CK1 PTS System FOG69_05790 ENOG4105VCP PTS System FOG69_05795 ENOG4105CS2 ec 3.2.1.21 FOG69_05800 ENOG4105E98 transcriptional regulator DeoR family FOG69_05820 ENOG4105KT7 mgtC SapB transporter FOG69_05840 ENOG4108IEG Formate dehydrogenase Alpha subunit FOG69_05850 ENOG4106A3M Cytochrome p-450 FOG69_05855 ENOG41087PP glycosyltransferase MGT family FOG69_05865 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FOG69_05870 ENOG4105C4B ABC transporter, permease FOG69_05875 ENOG4108IXI (ABC) transporter FOG69_05885 ENOG4105Q95 Cupin 2, conserved barrel domain protein FOG69_05900 ENOG4105D2H Uronic isomerase FOG69_05905 ENOG4107KJX Transcriptional regulator FOG69_05915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_05920 ENOG4105F3H Histidine kinase FOG69_05935 ENOG4107TSN permease FOG69_05955 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOG69_05960 ENOG4105KWG Pfam:DUF1696 FOG69_05965 ENOG4105K7W phage-related replication protein FOG69_05970 ENOG410635T phage-like element pbsx protein FOG69_06010 ENOG4108TFU terminase (Small subunit) FOG69_06015 ENOG4105IG6 Phage terminase, large subunit FOG69_06020 ENOG4108MDF Phage Portal Protein FOG69_06045 ENOG41060SN FOG69_06060 ENOG4105PQS phage protein FOG69_06065 ENOG4105FR7 XkdM protein, phage-like element PBSX FOG69_06070 ENOG4105MTC XkdN-like protein FOG69_06080 ENOG4108FKH Transglycosylase SLT domain FOG69_06080 ENOG4108FKH Transglycosylase SLT domain FOG69_06080 ENOG4108FKH Transglycosylase SLT domain FOG69_06085 ENOG4108WZM domain protein FOG69_06090 ENOG4105X7F FOG69_06100 ENOG4105MFU Protein of unknown function (DUF2634) FOG69_06105 ENOG41066EA baseplate J family protein FOG69_06110 ENOG410906S phage-like element pbsx protein xkdt FOG69_06120 ENOG41068G1 FOG69_06150 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOG69_06165 ENOG4105CJ3 phosphate transporter FOG69_06170 ENOG4107GRR phosphate transport regulator FOG69_06175 ENOG4107R7I amino acid FOG69_06185 ENOG4105EDW glycosyl transferase, family 39 FOG69_06190 ENOG4105CKK Glycosyl transferase, family 2 FOG69_06195 ENOG4105C0H protease FOG69_06205 ENOG4108ME1 Peptidase M55 D-aminopeptidase FOG69_06210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOG69_06215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOG69_06220 ENOG4105C3U ABC transporter FOG69_06230 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOG69_06235 ENOG4105DTQ mandelate racemase muconate lactonizing FOG69_06240 ENOG4107SN7 NLP P60 protein FOG69_06245 ENOG4108JQ7 (ABC) transporter FOG69_06250 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOG69_06255 ENOG4107TUM Amidinotransferase FOG69_06260 ENOG4108S4H thioesterase Superfamily protein FOG69_06265 ENOG4108428 Inherit from COG: -acetyltransferase FOG69_06275 ENOG41080TC multidrug resistance protein FOG69_06280 ENOG4105CIY formyltetrahydrofolate deformylase FOG69_06285 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOG69_06300 ENOG4105K56 Transcriptional regulator FOG69_06305 ENOG4108ZHJ Organic hydroperoxide resistance protein FOG69_06320 ENOG4107TVC Glycosyl transferase, family 2 FOG69_06335 ENOG4105D8G Major Facilitator superfamily FOG69_06340 ENOG4108Y4K DNA-binding transcriptional activator FOG69_06345 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOG69_06350 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOG69_06360 ENOG4108W7F transporter, permease FOG69_06365 ENOG4108JJB ABC transporter FOG69_06370 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FOG69_06375 ENOG4105VRS hydrolase family 18 FOG69_06390 ENOG4105CJW magnesium transporter FOG69_06395 ENOG4105V75 Transcriptional regulator FOG69_06420 ENOG4105DQE DNA ligase FOG69_06425 ENOG4105FDF Could be involved in DNA repair (By similarity) FOG69_06430 ENOG4105BZU Histidine kinase FOG69_06435 ENOG4107T5V SNARE associated Golgi FOG69_06440 ENOG4107TS3 membrane protein, TerC FOG69_06445 ENOG4108WZW RNA polymerase sigma FOG69_06455 ENOG410681C small acid-soluble spore protein FOG69_06465 ENOG4105D0M Protease HtpX homolog FOG69_06475 ENOG410900G Protein of unknown function (DUF421) FOG69_06485 ENOG4108TGC Acyltransferase FOG69_06490 ENOG4105BZU Histidine kinase FOG69_06495 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOG69_06500 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOG69_06510 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOG69_06520 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FOG69_06525 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FOG69_06530 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOG69_06535 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOG69_06550 ENOG4105BZU Histidine kinase FOG69_06555 ENOG41090MY MarR family Transcriptional regulator FOG69_06560 ENOG4105ER2 Ompa motb domain protein FOG69_06565 ENOG4105E14 MotA TolQ exbB proton channel FOG69_06580 ENOG4108K88 Membrane FOG69_06590 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOG69_06595 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FOG69_06600 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOG69_06605 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOG69_06625 ENOG4105F0V Cell wall hydrolase FOG69_06640 ENOG4105C59 p-type ATPase FOG69_06645 ENOG4105DC7 peptidase M24 FOG69_06655 ENOG4105CID antiterminator FOG69_06665 ENOG4105KRI phosphocarrier protein (HPr FOG69_06670 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOG69_06680 ENOG4105F6S Spore photoproduct lyase FOG69_06685 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOG69_06690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOG69_06700 ENOG4105K4I Scp-like extracellular FOG69_06710 ENOG4105BZU Histidine kinase FOG69_06715 ENOG4105CHM Aminotransferase FOG69_06725 ENOG4107R88 Chemotaxis protein (CheV) FOG69_06730 ENOG4105UIN FOG69_06740 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein FOG69_06750 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOG69_06760 ENOG4105EPM Diguanylate phosphodiesterase FOG69_06765 ENOG4107IN1 Protein of unknown function (DUF1797) FOG69_06770 ENOG4108XRC Protein of unknown function (DUF458) FOG69_06800 ENOG4105NQC Flavodoxin FOG69_06820 ENOG4105D8X mechanosensitive ion channel FOG69_06830 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOG69_06845 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FOG69_06850 ENOG4105D06 uba thif-type nad fad binding protein FOG69_06855 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOG69_06860 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOG69_06865 ENOG4108ZAF Molybdopterin FOG69_06870 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOG69_06880 ENOG4107X8C Efflux transporter RND family MFP subunit FOG69_06885 ENOG4105C19 ABC transporter FOG69_06890 ENOG4107RBB ABC transporter, permease FOG69_06895 ENOG4105E98 transcriptional regulator DeoR family FOG69_06900 ENOG4105DE4 1-phosphofructokinase FOG69_06905 ENOG4105DM4 PTS System FOG69_06920 ENOG4105C5H ABC transporter FOG69_06925 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOG69_06955 ENOG4105BZU Histidine kinase FOG69_06965 ENOG4107ZYR domain protein FOG69_06970 ENOG4105CPN adenine deaminase FOG69_06975 ENOG4105CN5 Metallo-Beta-Lactamase FOG69_06980 ENOG4106148 UPF0356 protein FOG69_06990 ENOG4108X4Q Hydrolase FOG69_06995 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOG69_07015 ENOG4105CPP Dehydrogenase, E1 component FOG69_07020 ENOG4105C7S Dehydrogenase FOG69_07025 ENOG4107QN2 dihydrolipoyl dehydrogenase FOG69_07045 ENOG4105CXN decarboxylase FOG69_07050 ENOG4105WBI UPF0223 protein FOG69_07070 ENOG4105ECY inositol monophosphatase FOG69_07080 ENOG4105D4Y metalloprotease FOG69_07105 ENOG4105CI3 gtp-binding protein typa FOG69_07110 ENOG4105QA2 FOG69_07125 ENOG4108IAB Phoh family FOG69_07135 ENOG4105CSV Glutaminase FOG69_07145 ENOG4105CNI cell division protein FtsW FOG69_07150 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOG69_07160 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOG69_07170 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOG69_07175 ENOG4105CCU oxidase (Subunit III) FOG69_07180 ENOG41064X9 cytochrome C oxidase subunit IV FOG69_07195 ENOG41080XQ Signal transduction protein with cbs domains FOG69_07200 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOG69_07225 ENOG4106H78 methyltransferase FOG69_07230 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOG69_07235 ENOG4105H20 Sporulation integral membrane protein YlbJ FOG69_07240 ENOG4105D78 K07001 NTE family protein FOG69_07245 ENOG41063PX domain protein FOG69_07250 ENOG4105CDE UPF0348 protein FOG69_07255 ENOG4105KNH Nucleic acid-binding protein FOG69_07260 ENOG41067VY 50S ribosomal protein L32 FOG69_07285 ENOG4108V6E Cell division protein mraZ FOG69_07290 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOG69_07300 ENOG4105CJN penicillin-binding protein FOG69_07305 ENOG4105CJN penicillin-binding protein FOG69_07310 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOG69_07315 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOG69_07320 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOG69_07325 ENOG4105CNI cell division protein FtsW FOG69_07330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOG69_07335 ENOG4105D4A Cell wall formation (By similarity) FOG69_07340 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOG69_07345 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOG69_07350 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOG69_07360 ENOG4105FFI sigma-e processing peptidase spoiiga FOG69_07365 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_07375 ENOG4105DKW ABC transporter FOG69_07385 ENOG4105WR5 sporulation protein, YlmC YmxH family FOG69_07390 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOG69_07395 ENOG4105DFA alanine racemase domain protein FOG69_07400 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FOG69_07405 ENOG41067XK integral membrane protein FOG69_07410 ENOG4105DBK s4 domain protein FOG69_07425 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOG69_07435 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOG69_07440 ENOG4105C34 Pseudouridine synthase FOG69_07445 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FOG69_07455 ENOG4105CXT aspartate transcarbamylase FOG69_07465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOG69_07470 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOG69_07475 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOG69_07480 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FOG69_07485 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FOG69_07490 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOG69_07505 ENOG4107RIQ Sulfate adenylate transferase FOG69_07515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOG69_07525 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOG69_07535 ENOG4105F23 Fibronectin-binding protein FOG69_07545 ENOG4105DSJ YicC domain protein FOG69_07550 ENOG4105KC4 UPF0296 protein FOG69_07555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOG69_07565 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOG69_07570 ENOG4105C25 Primosomal protein n' FOG69_07575 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOG69_07580 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOG69_07585 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOG69_07590 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOG69_07595 ENOG4108ZF3 Phosphatase FOG69_07600 ENOG4105D9P serine threonine protein kinase FOG69_07605 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOG69_07610 ENOG4105DJV ribulose-phosphate 3-epimerase FOG69_07615 ENOG4105FJ0 thiamine FOG69_07625 ENOG4105VB9 50S ribosomal protein l28 FOG69_07630 ENOG4108ZAA Alkaline-shock protein FOG69_07635 ENOG4105DP4 dak2 domain fusion protein ylov FOG69_07645 ENOG4105EJQ L-serine dehydratase FOG69_07650 ENOG4105CB5 ATP-dependent DNA helicase recG FOG69_07655 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FOG69_07660 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOG69_07665 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOG69_07670 ENOG4105CHR reductase FOG69_07675 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOG69_07680 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOG69_07685 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOG69_07690 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOG69_07695 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FOG69_07705 ENOG4105K5M 30s ribosomal protein S16 FOG69_07710 ENOG4108BW8 UPF0109 protein FOG69_07725 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOG69_07730 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOG69_07735 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOG69_07740 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOG69_07750 ENOG4105VM1 flagellar FOG69_07755 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOG69_07760 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOG69_07765 ENOG4105C79 DNA protecting protein DprA FOG69_07770 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOG69_07775 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FOG69_07780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOG69_07785 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOG69_07790 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOG69_07805 ENOG4108ZC9 flagellar basal-body rod protein flgc FOG69_07810 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOG69_07815 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOG69_07820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOG69_07835 ENOG4106YF4 Flagellar biosynthesis chaperone FOG69_07845 ENOG410696Y Flagellar hook-length control protein FOG69_07850 ENOG410822I Flagellar hook capping protein FOG69_07855 ENOG4108JQA flagellar FOG69_07860 ENOG41068WV flagellar FlbD family protein FOG69_07870 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOG69_07875 ENOG4105DD5 Flagellar motor switch protein FOG69_07880 ENOG4107YTP response regulator receiver protein FOG69_07890 ENOG4105CN7 Flagellar biosynthetic protein FliP FOG69_07895 ENOG4105VS8 Flagellar biosynthetic protein fliq FOG69_07900 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOG69_07905 ENOG4105D00 flagellar biosynthetic protein flhB FOG69_07910 ENOG4105D7B Flagellar biosynthesis protein flha FOG69_07915 ENOG4105FZW flagellar biosynthesis regulator FlhF FOG69_07925 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOG69_07930 ENOG4105CBS Chea signal transduction histidine kinase FOG69_07935 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FOG69_07945 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FOG69_07950 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_07960 ENOG4105CE9 30S ribosomal protein S2 FOG69_07970 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOG69_07975 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOG69_07980 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOG69_07985 ENOG4105KNE Phosphatidate cytidylyltransferase FOG69_07995 ENOG4105DZP Membrane-associated zinc metalloprotease FOG69_08000 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOG69_08005 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOG69_08010 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOG69_08015 ENOG4105CHV Transcription elongation factor NusA FOG69_08020 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOG69_08025 ENOG4105VHM ribosomal protein FOG69_08030 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOG69_08035 ENOG4105W7A Protein of unknown function (DUF503) FOG69_08040 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOG69_08045 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOG69_08050 ENOG4105DTN riboflavin biosynthesis protein ribF FOG69_08055 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOG69_08060 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOG69_08070 ENOG4105C1V Peptidase, M16 FOG69_08080 ENOG4105E35 Dipicolinate synthase subunit A FOG69_08085 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOG69_08090 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOG69_08100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOG69_08110 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOG69_08120 ENOG4105CNU cell division protein FtsK FOG69_08125 ENOG4105FDP GntR family transcriptional regulator FOG69_08140 ENOG4105EYF MMPL domain protein FOG69_08155 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOG69_08160 ENOG4105XZV Protein of unknown function (DUF3243) FOG69_08175 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOG69_08180 ENOG4105CEV competence damage-inducible protein FOG69_08185 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOG69_08190 ENOG4108A04 Beta-lactamase FOG69_08200 ENOG4105D48 metallophosphoesterase FOG69_08205 ENOG4105MCT stage V sporulation protein S FOG69_08210 ENOG4105CPQ Dehydrogenase FOG69_08215 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOG69_08220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOG69_08240 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOG69_08245 ENOG4108151 Beta-lactamase domain protein FOG69_08250 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOG69_08255 ENOG4108JA1 polyketide synthase FOG69_08260 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOG69_08265 ENOG41062T2 Acyl carrier protein FOG69_08270 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase FOG69_08275 ENOG4108MGH Enoyl-CoA hydratase FOG69_08280 ENOG4108KQ6 Enoyl-CoA hydratase FOG69_08285 ENOG4105C0W non-ribosomal peptide synthetase FOG69_08290 ENOG4107SQU synthase FOG69_08300 ENOG4105C0W non-ribosomal peptide synthetase FOG69_08310 ENOG4106A3M Cytochrome p-450 FOG69_08315 ENOG4105WFK nuclease FOG69_08320 ENOG4105XPP Protein of unknown function (DUF1275) FOG69_08330 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOG69_08340 ENOG4105K7W phage-related replication protein FOG69_08345 ENOG4108X3M OsmC Ohr family protein FOG69_08370 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOG69_08395 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOG69_08400 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOG69_08405 ENOG4105U6W MutT NUDIX family protein FOG69_08415 ENOG4106F1P AAA ATPase, central domain protein FOG69_08420 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOG69_08425 ENOG4105CXI aluminum resistance protein FOG69_08430 ENOG4105KV4 Transcriptional regulator FOG69_08435 ENOG4105C5F glutamine synthetase FOG69_08470 ENOG4107T94 Endo-14-beta-xylanase FOG69_08480 ENOG4105CT4 transporter FOG69_08485 ENOG4105DSG hydrolase family 43 FOG69_08495 ENOG4105C93 Xylose Isomerase FOG69_08500 ENOG4105CMG Carbohydrate kinase FOG69_08510 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOG69_08530 ENOG410780I phosphoprotein phosphatase activity FOG69_08550 ENOG4105DQ4 alcohol dehydrogenase FOG69_08570 ENOG4105EPI acetyltransferase, (GNAT) family FOG69_08605 ENOG4108M1A Chitin-binding protein FOG69_08625 ENOG4105YB8 TM2 domain containing protein FOG69_08630 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOG69_08640 ENOG4105K7W phage-related replication protein FOG69_08660 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOG69_08670 ENOG4108SVB resolvase FOG69_08675 ENOG4105VPS UPF0291 protein FOG69_08680 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOG69_08690 ENOG4105VXM UPF0154 protein FOG69_08700 ENOG4107QIV Cytochrome c biogenesis protein FOG69_08735 ENOG4108I0Z Aconitate hydratase FOG69_08740 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOG69_08755 ENOG41067CD Small, acid-soluble spore protein Tlp FOG69_08765 ENOG4105MI2 FOG69_08770 ENOG4105W8X HesB YadR YfhF-family protein FOG69_08775 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOG69_08780 ENOG4105K4P CoA-binding domain protein FOG69_08785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOG69_08815 ENOG4105FVX FOG69_08835 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOG69_08845 ENOG4107SYN Glycosyl hydrolases family 43 FOG69_08875 ENOG4105DTD Dehydrogenase FOG69_08880 ENOG4108IIH CoA-transferase subunit B FOG69_08885 ENOG4105D6N CoA-transferase, subunit a FOG69_08890 ENOG4106A3M Cytochrome p-450 FOG69_08895 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOG69_08900 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FOG69_08905 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOG69_08910 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOG69_08925 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOG69_08930 ENOG4107T5V SNARE associated Golgi FOG69_08935 ENOG4107QX3 carboxylase FOG69_08940 ENOG4105E39 Enoyl-CoA hydratase FOG69_08945 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOG69_08950 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOG69_08955 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOG69_08960 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_08965 ENOG4105C1G acyl-Coa dehydrogenase FOG69_08970 ENOG4105F32 YngK protein FOG69_08975 ENOG4106U2H Protein of unknown function (DUF1360) FOG69_08985 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_08995 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FOG69_09000 ENOG4108N2V aldose 1-epimerase FOG69_09005 ENOG4107QJQ Mate efflux family protein FOG69_09030 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOG69_09035 ENOG4108RWP Major Facilitator Superfamily protein FOG69_09040 ENOG4105WAB arsR family transcriptional regulator FOG69_09045 ENOG4105C22 threonyL-tRNA synthetase FOG69_09050 ENOG4108KSA LysR family transcriptional regulator FOG69_09055 ENOG4105CB2 alcohol dehydrogenase FOG69_09065 ENOG4105BZ8 glutamate synthase FOG69_09070 ENOG4105CBC glutamate synthase FOG69_09075 ENOG4105C5Q Transcriptional regulator FOG69_09080 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOG69_09105 ENOG4108UB7 FOG69_09110 ENOG4105IE8 Alpha-ketoglutarate permease FOG69_09115 ENOG4107U6E carbohydrate kinase FGGY FOG69_09120 ENOG4108M3J Dehydrogenase FOG69_09125 ENOG4108J2R molybdopterin oxidoreductase FOG69_09155 ENOG4108Z7R Chaperone CsaA FOG69_09160 ENOG4105FTV AraC Family Transcriptional Regulator FOG69_09170 ENOG4108W8B Beta-lactamase domain protein FOG69_09180 ENOG4105KTU Transcriptional regulator, arsr family FOG69_09190 ENOG4108SJC Membrane FOG69_09215 ENOG41069ER domain protein FOG69_09220 ENOG4105C9U ATP-dependent DNA helicase RecQ FOG69_09230 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOG69_09235 ENOG4105SCY DNAK suppressor FOG69_09280 ENOG4105C26 Dehydrogenase FOG69_09285 ENOG4105EWU Squalene--hopene cyclase FOG69_09290 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOG69_09295 ENOG4105C8J )-transporter FOG69_09300 ENOG4105C09 Bile acid FOG69_09310 ENOG4105C7S Dehydrogenase FOG69_09315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOG69_09320 ENOG4107T89 von Willebrand factor, type A FOG69_09325 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOG69_09335 ENOG4105K4H Nlp p60 protein FOG69_09340 ENOG41087PP glycosyltransferase MGT family FOG69_09350 ENOG4107QMU Mate efflux family protein FOG69_09355 ENOG4106SCS STAS domain FOG69_09375 ENOG4105FR1 rard protein FOG69_09390 ENOG41090U3 tautomerase FOG69_09410 ENOG4105FBA Phospholipase Carboxylesterase FOG69_09425 ENOG4105E1V na solute symporter FOG69_09435 ENOG4105CS2 ec 3.2.1.21 FOG69_09440 ENOG4108S3Y transcriptional regulator FOG69_09460 ENOG4108VXD carboxy-peptidase FOG69_09465 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOG69_09475 ENOG4106Z5R FOG69_09480 ENOG410841Q phosphoesterase PA-phosphatase related protein FOG69_09495 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOG69_09510 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOG69_09515 ENOG4108TSC N-acetyltransferase FOG69_09520 ENOG4107S4Y M20 DapE family protein YgeY FOG69_09535 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOG69_09545 ENOG4105FTQ Dna gyrase FOG69_09585 ENOG4105C5E polysaccharide biosynthesis protein FOG69_09595 ENOG4105DMF Dehydrogenase FOG69_09615 ENOG4105C5E polysaccharide biosynthesis protein FOG69_09620 ENOG4105E0X reductase FOG69_09625 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOG69_09635 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FOG69_09640 ENOG41090WU lipolytic protein G-D-S-L family FOG69_09645 ENOG4108KF3 Electron transport protein SCO1 SenC FOG69_09655 ENOG4105C7B Threonine dehydratase FOG69_09665 ENOG4108UT2 hemolysin iii FOG69_09675 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOG69_09680 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOG69_09690 ENOG4107YX5 Pfam:DUF548 FOG69_09695 ENOG4108Y6J UPF0403 protein FOG69_09700 ENOG4105C01 Dihydroxy-acid dehydratase FOG69_09715 ENOG4108V06 Glutathione peroxidase FOG69_09720 ENOG4105CVG Homoserine O-transsuccinylase FOG69_09765 ENOG41081VK Ribonuclease FOG69_09790 ENOG410890F Dynamin family FOG69_09805 ENOG41065KQ synthase FOG69_09835 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOG69_09865 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOG69_09870 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOG69_09890 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOG69_09935 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOG69_09940 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOG69_10020 ENOG4105DVF Cytosine-specific methyltransferase FOG69_10030 ENOG4106210 phosphatase activity FOG69_10095 ENOG4108R1E Serine threonine protein phosphatase 1 FOG69_10105 ENOG4105K7W phage-related replication protein FOG69_10140 ENOG4108RAV Conserved protein FOG69_10145 ENOG4108J9Q DNA ligase FOG69_10290 ENOG4107D0N FOG69_10370 ENOG4107NTZ FOG69_10400 ENOG4108ZUE Phage regulatory protein rha FOG69_10405 ENOG4105C4R Atp-dependent dna helicase FOG69_10425 ENOG4108NE4 FOG69_10465 ENOG4105ZUG FOG69_10470 ENOG4105K70 DNA-binding protein FOG69_10490 ENOG4106QVS FOG69_10570 ENOG41068G1 FOG69_10615 ENOG4105D9P serine threonine protein kinase FOG69_10660 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOG69_10685 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOG69_10715 ENOG4106BHF FOG69_10730 ENOG4107Y9E nuclease FOG69_10745 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FOG69_10750 ENOG4105CTD carboxy-peptidase FOG69_10755 ENOG4105DVT helicase FOG69_10775 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOG69_10785 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FOG69_10790 ENOG4108UKS UPF0398 protein FOG69_10805 ENOG4107X2U Inherit from COG: Exonuclease-like protein FOG69_10810 ENOG4108I5C dEAD DEAH box helicase FOG69_10855 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOG69_10860 ENOG4105BZ4 penicillin-binding protein FOG69_10870 ENOG4105CSM endonuclease III FOG69_10880 ENOG4105C5S asparaginyl-tRNA synthetase FOG69_10885 ENOG4105CHM Aminotransferase FOG69_10895 ENOG4105YAC FOG69_10900 ENOG4105DVT helicase FOG69_10905 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FOG69_10915 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOG69_10925 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOG69_10930 ENOG4105CPK Glycosyl transferase (Group 1 FOG69_10935 ENOG4105FJR Lmbe family FOG69_10940 ENOG4108Z5K methylglyoxal synthase FOG69_10945 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOG69_10950 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOG69_10955 ENOG4108JYZ YitT family FOG69_10960 ENOG4105F0F Oxalate decarboxylase FOG69_10980 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOG69_11000 ENOG41068YB TPR repeat-containing protein FOG69_11005 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOG69_11015 ENOG4105CIH Imidazole acetol-phosphate transaminase FOG69_11025 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOG69_11030 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FOG69_11035 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOG69_11045 ENOG4105CRQ synthase (Component I) FOG69_11050 ENOG4105KHN chorismate mutase FOG69_11060 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOG69_11065 ENOG4105BZU Histidine kinase FOG69_11070 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOG69_11075 ENOG4105EAH synthase FOG69_11080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOG69_11085 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOG69_11090 ENOG4105WP2 Tryptophan RNA-binding attenuator protein FOG69_11095 ENOG4105EUJ GTP cyclohydrolase i FOG69_11100 ENOG4105K70 DNA-binding protein FOG69_11105 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOG69_11120 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOG69_11125 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOG69_11145 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOG69_11150 ENOG4105CAT Cytidine monophosphate kinase FOG69_11160 ENOG4105MSI germination protein ypeb FOG69_11170 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) FOG69_11175 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOG69_11190 ENOG4107RGJ metallophosphoesterase FOG69_11205 ENOG4105I7S Abortive infection protein FOG69_11210 ENOG4105C9U ATP-dependent DNA helicase RecQ FOG69_11215 ENOG4105T7X FOG69_11225 ENOG4108SAX Membrane FOG69_11230 ENOG4108JQ1 Dehydrogenase FOG69_11245 ENOG4105BZU Histidine kinase FOG69_11250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_11255 ENOG4105CRE cytochrome C FOG69_11260 ENOG4107TWT Cytochrome c biogenesis protein FOG69_11270 ENOG4105FE9 pseudouridine synthase FOG69_11280 ENOG4108JIC nucleoside recognition domain protein FOG69_11285 ENOG4105DZ1 carboxypeptidase FOG69_11295 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOG69_11300 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOG69_11325 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOG69_11330 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOG69_11335 ENOG4108R6K riboflavin synthase, subunit alpha FOG69_11360 ENOG4107ZE5 PPIases accelerate the folding of proteins FOG69_11365 ENOG4105PTM secreted protein FOG69_11370 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOG69_11380 ENOG4105G6R Stage v sporulation protein ae FOG69_11390 ENOG4105CZ3 stage V sporulation protein ad FOG69_11395 ENOG41090VF Stage v sporulation protein ac FOG69_11410 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_11415 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FOG69_11420 ENOG41082AN stage II sporulation protein FOG69_11425 ENOG4105DZ1 carboxypeptidase FOG69_11430 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FOG69_11435 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FOG69_11440 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOG69_11450 ENOG4105I3K Ferric uptake regulator, Fur family FOG69_11455 ENOG4105MZ9 stage II sporulation protein m FOG69_11475 ENOG4105DFD Na H antiporter FOG69_11480 ENOG4108IJ0 Aspartate ammonia-lyase FOG69_11485 ENOG4105HDK L-asparaginase FOG69_11490 ENOG4108IMY Transcriptional regulator FOG69_11500 ENOG4108YZ4 nudix hydrolase FOG69_11510 ENOG4105CPC Aldo Keto reductase FOG69_11530 ENOG4106HZJ FOG69_11535 ENOG4105RHY Pfam:UPF0157 FOG69_11540 ENOG4108XET gCN5-related N-acetyltransferase FOG69_11545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOG69_11560 ENOG4105C02 permease FOG69_11570 ENOG4105CS9 pantothenic acid kinase FOG69_11580 ENOG4108IXY short-chain dehydrogenase reductase FOG69_11585 ENOG41069FQ Metallo-beta-lactamase superfamily FOG69_11590 ENOG4105II7 pyrroline-5-carboxylate reductase FOG69_11600 ENOG4108K70 Transcriptional regulator FOG69_11610 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOG69_11620 ENOG410861F 50S ribosomal protein L33 FOG69_11625 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOG69_11630 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOG69_11635 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOG69_11640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOG69_11650 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FOG69_11655 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOG69_11660 ENOG4108HNZ carboxyl transferase FOG69_11665 ENOG4108ZVT methylmalonyl-coA epimerase FOG69_11670 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOG69_11675 ENOG4108QEG Membrane FOG69_11680 ENOG4105CDA abc transporter atp-binding protein FOG69_11685 ENOG4105E5Q amino acid AbC transporter FOG69_11690 ENOG4108HW3 (ABC) transporter FOG69_11695 ENOG4108Y6J UPF0403 protein FOG69_11700 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOG69_11705 ENOG4105C7S Dehydrogenase FOG69_11710 ENOG4105CPP Dehydrogenase, E1 component FOG69_11725 ENOG4105CKM Branched-chain carboxylic acid kinase FOG69_11730 ENOG4107RDP Dehydrogenase FOG69_11740 ENOG4108JUB Transcriptional regulator FOG69_11745 ENOG4106CCJ Protein of unknown function (DUF2627) FOG69_11750 ENOG4105CR4 methylisocitrate lyase FOG69_11755 ENOG4105DXD 2-methylcitrate dehydratase FOG69_11765 ENOG4105C1G acyl-Coa dehydrogenase FOG69_11770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOG69_11780 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOG69_11785 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOG69_11805 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOG69_11820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOG69_11825 ENOG4107QQR Sporulation FOG69_11830 ENOG4105S1Z Stage IV sporulation protein B FOG69_11835 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOG69_11840 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOG69_11845 ENOG4105DX0 Hemolysin A FOG69_11850 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOG69_11855 ENOG4105CTB Polyprenyl synthetase FOG69_11860 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOG69_11865 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOG69_11870 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOG69_11875 ENOG4105M7K Involved in the transcription termination process (By similarity) FOG69_11880 ENOG4108ZSR alkaline shock protein FOG69_11885 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOG69_11905 ENOG410644B Stage III sporulation protein af FOG69_11915 ENOG4105KQ4 Stage iii sporulation protein ad FOG69_11920 ENOG4108CQH stage III sporulation protein AC FOG69_11925 ENOG4105KR5 Stage iii sporulation protein FOG69_11930 ENOG4105CD2 stage iii sporulation protein aa FOG69_11940 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOG69_11945 ENOG4105DC7 peptidase M24 FOG69_11955 ENOG4105CBJ Metal-dependent enzyme FOG69_11975 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOG69_11980 ENOG4105WZW rhodanese family FOG69_11985 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOG69_11995 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOG69_12000 ENOG4105C0D helicase FOG69_12015 ENOG4108IMY Transcriptional regulator FOG69_12025 ENOG4105VFR signal peptidase FOG69_12085 ENOG4105C37 (CBS) domain FOG69_12110 ENOG4105C5X domain protein FOG69_12155 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOG69_12160 ENOG4105WDJ 50S ribosomal protein L33 FOG69_12170 ENOG41068DG YceG-like family FOG69_12175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOG69_12180 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOG69_12185 ENOG4105E2Z phosphate ABC transporter (Permease FOG69_12190 ENOG4105C8U phosphate abc transporter FOG69_12195 ENOG4105CVA phosphate FOG69_12200 ENOG4107RF6 penicillin-binding protein FOG69_12210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOG69_12215 ENOG4105SXS Protein of unknown function (DUF456) FOG69_12230 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FOG69_12235 ENOG41063Y9 FOG69_12240 ENOG4108U5J '-nucleotidase FOG69_12245 ENOG4105N80 Ferric uptake regulator, Fur family FOG69_12250 ENOG4108JYZ YitT family FOG69_12255 ENOG41069ZM Protein of unknown function (DUF2624) FOG69_12260 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FOG69_12275 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOG69_12280 ENOG4105EGD dinuclear metal center protein, YbgI family FOG69_12295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_12300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOG69_12305 ENOG4108UPT UPF0178 protein FOG69_12310 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FOG69_12320 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOG69_12325 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOG69_12330 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) FOG69_12340 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOG69_12345 ENOG4105KG3 cytidine deaminase FOG69_12350 ENOG4107YR5 Diacylglycerol kinase FOG69_12355 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOG69_12360 ENOG4105CTJ Metal Dependent Phosphohydrolase FOG69_12365 ENOG4105C9A Phoh family FOG69_12370 ENOG4105EI1 sporulation protein yqfd FOG69_12375 ENOG41068P3 sporulation protein YqfC FOG69_12385 ENOG4105DI5 UPF0365 protein FOG69_12390 ENOG4105F7J membrane-bound serine protease FOG69_12395 ENOG4105KTH gatB Yqey FOG69_12410 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOG69_12415 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOG69_12420 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOG69_12425 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOG69_12430 ENOG4105CFG Acts as a chaperone (By similarity) FOG69_12435 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOG69_12440 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOG69_12445 ENOG4105CSA Coproporphyrinogen iii oxidase FOG69_12450 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOG69_12460 ENOG4108ZRV stage ii sporulation protein p FOG69_12465 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) FOG69_12470 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOG69_12475 ENOG4105TQK DNA polymerase iii, delta' subunit FOG69_12490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOG69_12495 ENOG4108UK2 deaminase FOG69_12500 ENOG4105KQC Competence protein FOG69_12510 ENOG4108D32 Methyltransferase FOG69_12520 ENOG4108WF2 Metal Dependent Phosphohydrolase FOG69_12525 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOG69_12530 ENOG410812S Rna-binding protein FOG69_12535 ENOG4105E2X shikimate dehydrogenase FOG69_12540 ENOG4105CQW ribosome biogenesis GTPase YqeH FOG69_12545 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOG69_12565 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOG69_12570 ENOG41080BT SNARE associated Golgi FOG69_12585 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_12605 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_12610 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOG69_12620 ENOG4108J8C transporter major facilitator family protein FOG69_12630 ENOG4108U7W acetyltransferase FOG69_12640 ENOG4108HCJ Hydrolase FOG69_12645 ENOG4108HCJ Hydrolase FOG69_12655 ENOG4105DG6 mannose-6-phosphate isomerase FOG69_12660 ENOG4105DM4 PTS System FOG69_12675 ENOG4108Z66 YbaK ebsC protein FOG69_12680 ENOG4107RSM transcriptional regulator FOG69_12685 ENOG4105D94 Major Facilitator Superfamily FOG69_12690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOG69_12695 ENOG41082JN Transcriptional regulator FOG69_12710 ENOG4105TMB Formate nitrite transporter FOG69_12715 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOG69_12720 ENOG4108JB9 formate dehydrogenase FOG69_12735 ENOG4105C28 cystathionine FOG69_12765 ENOG4107XRG penicillin-binding protein FOG69_12770 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOG69_12780 ENOG4105CFP Peptidase U32 FOG69_12785 ENOG4105XYU peptidase (U32 family) FOG69_12790 ENOG4108VQJ O-methyltransferase FOG69_12795 ENOG4105HHA aminodeoxychorismate lyase FOG69_12805 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOG69_12810 ENOG4105VBH UPF0297 protein FOG69_12815 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOG69_12820 ENOG4105C02 permease FOG69_12825 ENOG4105CDA abc transporter atp-binding protein FOG69_12830 ENOG4105CT1 (ABC) transporter FOG69_12835 ENOG4105EAD ABC transporter FOG69_12840 ENOG4105DRP amino acid AbC transporter FOG69_12850 ENOG41060CR FOG69_12860 ENOG4105C7H Helicase, RecD TraA family FOG69_12870 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOG69_12875 ENOG4105C3J Cysteine desulfurase FOG69_12885 ENOG4105D1H recombination factor protein RarA FOG69_12890 ENOG4105CUZ uba thif-type nad fad binding protein FOG69_12900 ENOG4105C9M aspartyl-trna synthetase FOG69_12905 ENOG4105CUT histidyl-tRNA synthetase FOG69_12915 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOG69_12920 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOG69_12925 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOG69_12935 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOG69_12940 ENOG41067VP Protein of unknown function (DUF1049) FOG69_12945 ENOG4105NCW Trka-c domain protein FOG69_12950 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOG69_12960 ENOG4105CKP Polysaccharide Biosynthesis Protein FOG69_12965 ENOG4108QG2 Membrane FOG69_12970 ENOG4105NAP FOG69_12975 ENOG4105VIE preprotein translocase, subunit YajC FOG69_12980 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOG69_12985 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOG69_12990 ENOG41061AI Protein of unknown function (DUF2905) FOG69_12995 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOG69_13000 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOG69_13015 ENOG4106678 morphogenetic protein associated with SpoVID FOG69_13020 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOG69_13025 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOG69_13030 ENOG4108IYU L-aspartate oxidase FOG69_13045 ENOG4105CQC Prephenate dehydratase FOG69_13055 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOG69_13065 ENOG4105K46 50S ribosomal protein l27 FOG69_13070 ENOG4105X36 (ribosomal) protein FOG69_13075 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOG69_13090 ENOG4107QMS site-determining protein FOG69_13095 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOG69_13100 ENOG4105YHC Rod shape-determining protein MreD FOG69_13105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOG69_13110 ENOG4105DFF Rod shape-determining protein mreb FOG69_13115 ENOG4105W5Q DNA repair protein (RadC FOG69_13120 ENOG4108Z03 MAF-like protein FOG69_13130 ENOG4106A3R peptidase FOG69_13135 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOG69_13140 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOG69_13150 ENOG4106AR7 Spore coat protein FOG69_13155 ENOG41068KH stage VI sporulation protein D FOG69_13160 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOG69_13165 ENOG4105D52 delta-aminolevulinic acid dehydratase FOG69_13175 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOG69_13185 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOG69_13195 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOG69_13200 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOG69_13205 ENOG4108IUQ atp-dependent protease FOG69_13210 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOG69_13215 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOG69_13225 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOG69_13230 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOG69_13235 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOG69_13245 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOG69_13250 ENOG4108ZP8 Acetolactate synthase small subunit FOG69_13255 ENOG4105C7K acetolactate synthase FOG69_13280 ENOG4105M59 Phosphodiesterase, mj0936 family FOG69_13285 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOG69_13290 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOG69_13295 ENOG4108XJQ germination protein FOG69_13300 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOG69_13305 ENOG41067TZ transcriptional regulator, MarR family FOG69_13310 ENOG4105PFC Transcriptional regulator FOG69_13320 ENOG4105E33 succinate dehydrogenase FOG69_13330 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOG69_13340 ENOG4105CFH Aspartokinase FOG69_13345 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOG69_13350 ENOG4105K63 Thioredoxin FOG69_13355 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOG69_13360 ENOG4105C10 Electron transfer flavoprotein FOG69_13365 ENOG4105BZJ Electron transfer flavoprotein FOG69_13370 ENOG41060WC Enoyl-CoA hydratase FOG69_13375 ENOG4107Z3H Transcriptional regulator, TetR family FOG69_13380 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_13395 ENOG4105C98 muts2 protein FOG69_13400 ENOG4105DCG PHP domain protein FOG69_13415 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOG69_13420 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOG69_13425 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOG69_13430 ENOG4108RWN rrna methyltransferase FOG69_13435 ENOG41067MF small acid-soluble spore protein FOG69_13445 ENOG4105CQB FAD linked oxidase domain protein FOG69_13450 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOG69_13460 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FOG69_13465 ENOG4105DRS transport system, permease FOG69_13480 ENOG4108MDK Dehydrogenase FOG69_13490 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FOG69_13495 ENOG4105EF1 ribulokinase FOG69_13505 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FOG69_13510 ENOG4105CN9 Peptidase m42 family protein FOG69_13520 ENOG410696E Membrane FOG69_13525 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOG69_13530 ENOG4105VJV 50s ribosomal protein L35 FOG69_13535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOG69_13540 ENOG41067MG lrgb family FOG69_13550 ENOG4105DY9 regulatoR FOG69_13555 ENOG4108HRK Histidine kinase FOG69_13560 ENOG4105U0R haloacid dehalogenase-like hydrolase FOG69_13565 ENOG4105C22 threonyL-tRNA synthetase FOG69_13570 ENOG4108TDW sporulation protein YtxC FOG69_13595 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOG69_13600 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOG69_13605 ENOG4105KVH Transcriptional regulator FOG69_13610 ENOG4105F27 Major Facilitator FOG69_13615 ENOG4105CV8 reductase FOG69_13620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOG69_13630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOG69_13635 ENOG4105C2M dna polymerase I FOG69_13640 ENOG4105BZU Histidine kinase FOG69_13645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOG69_13655 ENOG4108HMX isocitrate dehydrogenase (NADP) FOG69_13660 ENOG4105BZN citrate synthase FOG69_13670 ENOG4108REF Sporulation integral membrane protein ytvi FOG69_13675 ENOG4105FS0 cytoplasmic membrane protein FOG69_13680 ENOG4105CA9 Pyruvate kinase FOG69_13685 ENOG4105CTQ phosphohexokinase FOG69_13690 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOG69_13695 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOG69_13700 ENOG4105C6K Malic enzyme FOG69_13705 ENOG4105C0B DNA polymerase III (alpha subunit) FOG69_13710 ENOG4105VV2 FOG69_13720 ENOG4106EVM FOG69_13725 ENOG4105SFS phosphoesterase RecJ domain protein FOG69_13740 ENOG4105E8R UPF0173 metal-dependent hydrolase FOG69_13750 ENOG4105CH7 arginosuccinase FOG69_13755 ENOG4105CDH Citrulline--aspartate ligase FOG69_13760 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOG69_13765 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOG69_13775 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOG69_13780 ENOG4105KBJ sporulation protein ytfj FOG69_13790 ENOG4105VK3 rdd domain containing protein FOG69_13795 ENOG4105D07 Signal peptide peptidase, SppA FOG69_13800 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOG69_13805 ENOG4105EFZ amidohydrolase FOG69_13810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOG69_13820 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FOG69_13845 ENOG4105U5Y Transcriptional regulator FOG69_13855 ENOG4105BZU Histidine kinase FOG69_13865 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOG69_13870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOG69_13900 ENOG4108NGU Transcriptional regulator FOG69_13905 ENOG4108UMN azlc family FOG69_13915 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOG69_13925 ENOG4105F1V Acetoin utilization protein FOG69_13930 ENOG4105W87 Cbs domain FOG69_13935 ENOG4105DGU Histone deacetylase FOG69_13940 ENOG4105ER2 Ompa motb domain protein FOG69_13945 ENOG4107R0U MotA TolQ exbB proton channel FOG69_13950 ENOG4105ETE Transcriptional regulator (LacI family FOG69_13955 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOG69_13975 ENOG4105DFU Cell wall formation (By similarity) FOG69_13985 ENOG4108VDD TRNA binding domain protein FOG69_14000 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FOG69_14015 ENOG4105C6K Malic enzyme FOG69_14020 ENOG4105C8F Beta-lactamase domain protein FOG69_14025 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOG69_14035 ENOG4108V15 phosphotransferase enzyme family FOG69_14050 ENOG4107F58 2'-5' rna ligase FOG69_14055 ENOG4105C6T cysteine synthase FOG69_14060 ENOG4107QSE Dipeptidase FOG69_14065 ENOG4105C7N Xanthine uracil vitamin C permease FOG69_14080 ENOG4105YW5 deoR family transcriptional regulator FOG69_14095 ENOG4105CBX hi0933 family FOG69_14100 ENOG4105C94 Transporter FOG69_14120 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FOG69_14125 ENOG4105I1K ABC transporter FOG69_14140 ENOG41085GJ domain protein FOG69_14145 ENOG4105C8T Leucyl-tRNA synthetase FOG69_14155 ENOG4105BZU Histidine kinase FOG69_14160 ENOG410605W Major Facilitator FOG69_14175 ENOG4105C19 ABC transporter FOG69_14180 ENOG4105EWM Histidine kinase FOG69_14190 ENOG4107R34 abc transporter permease protein FOG69_14195 ENOG4105C19 ABC transporter FOG69_14215 ENOG4105DVE abc transporter atp-binding protein FOG69_14220 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOG69_14230 ENOG4105N5T Radical SAM Protein FOG69_14250 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOG69_14255 ENOG4108Z0R Transferase FOG69_14260 ENOG4105C85 amino acid FOG69_14265 ENOG4105CAQ asparagine synthetase FOG69_14270 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOG69_14275 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FOG69_14290 ENOG4105D2X ABC transporter substrate-binding protein FOG69_14300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOG69_14315 ENOG4108RMU ferritin dps family protein FOG69_14330 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FOG69_14335 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOG69_14340 ENOG4108V2W Carbonate dehydratase FOG69_14345 ENOG4105NRA 50s ribosomal protein l31 type b FOG69_14365 ENOG4105DTQ mandelate racemase muconate lactonizing FOG69_14370 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_14375 ENOG4108IPT Naphthoate synthase FOG69_14380 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOG69_14385 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOG69_14390 ENOG4105E4F Isochorismate synthase FOG69_14525 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOG69_14530 ENOG4105DZ6 Band 7 protein FOG69_14540 ENOG4106DF1 FOG69_14545 ENOG4108VNY MOSC domain protein FOG69_14550 ENOG4108JB8 alcohol dehydrogenase FOG69_14555 ENOG4105C26 Dehydrogenase FOG69_14560 ENOG4105TRT Transcriptional regulator FOG69_14575 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOG69_14580 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOG69_14655 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOG69_14675 ENOG41068G1 FOG69_14695 ENOG4108FKH Transglycosylase SLT domain FOG69_14840 ENOG4105VTR Integrase FOG69_14850 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOG69_14860 ENOG4105EE0 oxidoreductase FOG69_14865 ENOG4108Z0Z intracellular protease Pfpi family FOG69_14870 ENOG4105C8Q Methyl-accepting chemotaxis FOG69_14875 ENOG4105C8Q Methyl-accepting chemotaxis FOG69_14880 ENOG4105C8Q Methyl-accepting chemotaxis FOG69_14885 ENOG4105C8Q Methyl-accepting chemotaxis FOG69_14900 ENOG4105EA8 2-Nitropropane dioxygenase FOG69_14915 ENOG4105C37 (CBS) domain FOG69_14930 ENOG4107PBV potassium channel FOG69_14935 ENOG4107PBV potassium channel FOG69_14950 ENOG4107QYV phosphohexose isomerase FOG69_14960 ENOG4107QW4 alcohol dehydrogenase FOG69_14965 ENOG4105WG9 Conserved Protein FOG69_14975 ENOG4105CHM Aminotransferase FOG69_14980 ENOG4108ZB6 transcriptional regulator AsnC family FOG69_14985 ENOG4108MUZ hydrolase FOG69_14995 ENOG4105C87 Aminotransferase class I and II FOG69_15000 ENOG4108HGU Histidine kinase FOG69_15005 ENOG4105Y38 Kinase-associated protein B FOG69_15020 ENOG4105BZ4 penicillin-binding protein FOG69_15025 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FOG69_15040 ENOG4108MRH transcriptional regulatory protein FOG69_15045 ENOG4105DIH basic membrane FOG69_15050 ENOG4108JQ9 ABC transporter FOG69_15055 ENOG4105UIB (ABC) transporter FOG69_15070 ENOG4105D65 subunit l FOG69_15075 ENOG4105HC0 Na H antiporter FOG69_15080 ENOG4108ZE9 Monovalent cation H antiporter subunit C FOG69_15085 ENOG4108JPZ Monovalent cation H antiporter subunit D FOG69_15090 ENOG4105SC1 monovalent cation H antiporter subunit E FOG69_15100 ENOG4105KJM monovalent cation h antiporter subunit g FOG69_15105 ENOG4105KA0 thioesterase Superfamily protein FOG69_15115 ENOG4105BZU Histidine kinase FOG69_15145 ENOG4105D58 Diguanylate phosphodiesterase FOG69_15150 ENOG4105DAP Nicotinate phosphoribosyltransferase FOG69_15175 ENOG4105C02 permease FOG69_15190 ENOG410904N short-chain dehydrogenase reductase FOG69_15225 ENOG4108K8K Transcriptional regulator FOG69_15230 ENOG4105DCF alanine dehydrogenase FOG69_15240 ENOG4105WQT MbtH domain protein FOG69_15245 ENOG4105CEY Amp-dependent synthetase and ligase FOG69_15250 ENOG4105WQI isochorismatase FOG69_15255 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOG69_15260 ENOG4105E4F Isochorismate synthase FOG69_15265 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOG69_15270 ENOG4105NIV Esterase FOG69_15290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOG69_15300 ENOG41069ER domain protein FOG69_15315 ENOG4105CEP NADH dehydrogenase FOG69_15330 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FOG69_15345 ENOG4105CJ1 ABC, transporter FOG69_15370 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOG69_15390 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOG69_15410 ENOG41068G1 FOG69_15425 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOG69_15605 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOG69_15610 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOG69_15615 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOG69_15625 ENOG4105ZKE UPF0349 protein FOG69_15640 ENOG41083MR nifu domain-containing protein FOG69_15645 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOG69_15650 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOG69_15655 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FOG69_15660 ENOG4105D6E homoserine dehydrogenase FOG69_15670 ENOG4108W5N phosphatidylglycerophosphatase a FOG69_15675 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOG69_15685 ENOG4105MMD transcriptional regulator FOG69_15695 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOG69_15700 ENOG4105FAA peptidase M23 FOG69_15705 ENOG4108YTE sporulation protein YunB FOG69_15710 ENOG4107R8B 5'-nucleotidase FOG69_15720 ENOG4105I3N Conserved Protein FOG69_15730 ENOG4105CD3 dihydroorotase FOG69_15735 ENOG4105G9B Transcriptional regulator FOG69_15745 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) FOG69_15760 ENOG4105C5R Aminotransferase FOG69_15770 ENOG4108K8S endonuclease I FOG69_15775 ENOG4108IJ9 (ABC) transporter FOG69_15780 ENOG4105FDP GntR family transcriptional regulator FOG69_15785 ENOG4108KPW sugar kinase FOG69_15790 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FOG69_15795 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FOG69_15800 ENOG4105XN3 extracellular solute-binding protein family 1 FOG69_15805 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FOG69_15835 ENOG4105PKS Excinuclease abc c subunit domain protein FOG69_15840 ENOG4107VFR oxidoreductase FOG69_15855 ENOG41083Q9 chitosanase FOG69_15860 ENOG4105DIW FeS assembly protein SUFB FOG69_15865 ENOG4108UNV SUF system FeS assembly protein, NifU family FOG69_15870 ENOG4105C9B Cysteine desulfurase FOG69_15875 ENOG4105JRK feS assembly protein SufD FOG69_15880 ENOG4105C3K feS assembly ATPase SufC FOG69_15900 ENOG4105D01 (LipO)protein FOG69_15905 ENOG4108UMI ABC transporter, permease FOG69_15910 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOG69_15935 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOG69_15940 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOG69_15945 ENOG4105C1G acyl-Coa dehydrogenase FOG69_15950 ENOG4105CHU acetyl-coa acetyltransferase FOG69_15980 ENOG41067TZ transcriptional regulator, MarR family FOG69_15985 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOG69_16015 ENOG4105E0A ABC, transporter FOG69_16030 ENOG4105E1F short-chain dehydrogenase reductase FOG69_16035 ENOG4105HUF DNA protection during starvation protein FOG69_16040 ENOG4105C0H protease FOG69_16050 ENOG4105F3H Histidine kinase FOG69_16060 ENOG41067SE Tetr family transcriptional regulator FOG69_16065 ENOG4105C9Q fumarate hydratase class II FOG69_16090 ENOG4105WH1 Two component transcriptional regulator luxr family FOG69_16095 ENOG4105ENE Histidine kinase FOG69_16110 ENOG41087YS Phage shock protein A FOG69_16125 ENOG4108WBT adenosyltransferase FOG69_16130 ENOG4105E0A ABC, transporter FOG69_16135 ENOG4105EHG Permease protein FOG69_16140 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOG69_16145 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOG69_16150 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOG69_16160 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOG69_16170 ENOG4106DF4 Sigma-70, region 4 FOG69_16180 ENOG4105F0F Oxalate decarboxylase FOG69_16190 ENOG4105E0A ABC, transporter FOG69_16195 ENOG4105EHG Permease protein FOG69_16200 ENOG4105DQ5 transport system permease protein FOG69_16210 ENOG4105JQZ Methyltransferase FOG69_16215 ENOG4105D5Q Arginine ornithine antiporter FOG69_16230 ENOG4107K5X Membrane-bound metal-dependent hydrolase FOG69_16235 ENOG4107QZ2 Sulfatase FOG69_16240 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOG69_16245 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOG69_16250 ENOG4105E0C molybdate abc transporter FOG69_16255 ENOG4105WH1 Two component transcriptional regulator luxr family FOG69_16265 ENOG4105CJ1 ABC, transporter FOG69_16275 ENOG4108KYE ABC-2 type transporter FOG69_16290 ENOG4105EEQ Na H antiporter FOG69_16300 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOG69_16305 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOG69_16310 ENOG4105EEM helicase FOG69_16315 ENOG4105EN6 Membrane FOG69_16330 ENOG4107ZQN disulfide bond FOG69_16335 ENOG4105C59 p-type ATPase FOG69_16340 ENOG4105C59 p-type ATPase FOG69_16345 ENOG410681U heavy metal transport detoxification protein FOG69_16350 ENOG4105VPX protein, conserved in bacteria FOG69_16355 ENOG4105D9R oxidoreductase FOG69_16360 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOG69_16375 ENOG4105DEN Luciferase family FOG69_16380 ENOG4105CDA abc transporter atp-binding protein FOG69_16405 ENOG4108XSB acetyltransferase, (GNAT) family FOG69_16410 ENOG4108KSA LysR family transcriptional regulator FOG69_16415 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOG69_16420 ENOG41067XF inhibitor FOG69_16430 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOG69_16435 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOG69_16445 ENOG4105XZU Preprotein translocase, subunit SecG FOG69_16465 ENOG4105KVH Transcriptional regulator FOG69_16490 ENOG4105DA5 (ABC) transporter FOG69_16495 ENOG4105R40 Glycine betaine carnitine choline FOG69_16500 ENOG4108HQR Glycine betaine FOG69_16505 ENOG4105E90 ABC transporter FOG69_16510 ENOG4108IJ8 ABC transporter FOG69_16515 ENOG4107HG4 Transcriptional regulator FOG69_16520 ENOG4105R40 Glycine betaine carnitine choline FOG69_16525 ENOG4108HQR Glycine betaine FOG69_16530 ENOG4105E90 ABC transporter FOG69_16535 ENOG4108IJ8 ABC transporter FOG69_16540 ENOG4107HG4 Transcriptional regulator FOG69_16545 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FOG69_16560 ENOG4108W0I acetyltransferase FOG69_16575 ENOG4105FJR Lmbe family FOG69_16595 ENOG4108IAJ Nad-dependent epimerase dehydratase FOG69_16600 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOG69_16605 ENOG4107QQG Dehydrogenase FOG69_16610 ENOG4105IIU Aminopeptidase FOG69_16615 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOG69_16620 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOG69_16625 ENOG4105CP7 Triose-phosphate isomerase FOG69_16630 ENOG4105BZA Phosphoglycerate kinase FOG69_16640 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOG69_16655 ENOG4105CMD Transcriptional regulator, GntR family FOG69_16660 ENOG4105DEN Luciferase family FOG69_16665 ENOG4105GZI Transcriptional regulator FOG69_16670 ENOG4107RT3 EamA-like transporter family FOG69_16680 ENOG4106KNT transcriptional regulator FOG69_16685 ENOG4105CMG Carbohydrate kinase FOG69_16690 ENOG4105C6Z Gluconate FOG69_16700 ENOG4107QR9 Iron-sulfur cluster binding protein FOG69_16705 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOG69_16715 ENOG4105JXH GntR family transcriptional regulator FOG69_16720 ENOG4105DAA L-lactate FOG69_16725 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOG69_16735 ENOG4108ZPC Polysaccharide pyruvyl transferase FOG69_16740 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOG69_16745 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FOG69_16750 ENOG4105D3Q Sugar transferase FOG69_16760 ENOG4105K64 Glycosyl transferase, family 2 FOG69_16770 ENOG4107QRS glycosyltransferase group 2 family protein FOG69_16775 ENOG41068W6 Capsular polysaccharide biosynthesis protein FOG69_16780 ENOG4108KMV Glycosyl transferase (Group 1 FOG69_16785 ENOG4105K64 Glycosyl transferase, family 2 FOG69_16790 ENOG4108PQP glycosyl transferase group 1 FOG69_16800 ENOG4108QV3 biosynthesis protein FOG69_16805 ENOG4105HTX biosynthesis protein FOG69_16815 ENOG4105EBR Carboxylesterase FOG69_16825 ENOG4105NAE bifunctional deaminase-reductase domain protein FOG69_16830 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FOG69_16845 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOG69_16850 ENOG4105PY6 Phenolic acid decarboxylase FOG69_16855 ENOG4105NI3 Protein of unknown function (DUF3237) FOG69_16895 ENOG4108HKT sucrose-6-phosphate hydrolase FOG69_16900 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FOG69_16905 ENOG4105ETE Transcriptional regulator (LacI family FOG69_16910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOG69_16915 ENOG4108KAM Transcriptional regulator FOG69_16920 ENOG4105C7F AcnD-accessory protein PrpF FOG69_16935 ENOG4108URH decarboxylase FOG69_16940 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FOG69_16945 ENOG4105CHH sulfate transporter FOG69_16950 ENOG4108V2W Carbonate dehydratase FOG69_16960 ENOG4105C5I Dehydrogenase FOG69_16965 ENOG4105GGE ribonuclease FOG69_16970 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOG69_16975 ENOG4105KRI phosphocarrier protein (HPr FOG69_16980 ENOG4105CIE May be required for sporulation (By similarity) FOG69_16985 ENOG4105CHW UPF0052 protein FOG69_16990 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOG69_16995 ENOG4108Z4K mutator MutT protein FOG69_17000 ENOG4105C3M thioredoxin reductase FOG69_17015 ENOG4105BZU Histidine kinase FOG69_17020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_17025 ENOG4105BZ1 (ABC) transporter FOG69_17030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOG69_17035 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOG69_17040 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOG69_17045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOG69_17050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOG69_17055 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOG69_17060 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOG69_17065 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FOG69_17075 ENOG4108S4C acetyltransferase FOG69_17080 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOG69_17090 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FOG69_17095 ENOG4105CE4 GlcNAc 6-P deacetylase FOG69_17100 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOG69_17105 ENOG4105FDP GntR family transcriptional regulator FOG69_17110 ENOG4105J7D transcriptional regulator FOG69_17115 ENOG41088CQ domain protein FOG69_17120 ENOG41086DT Membrane protein of unknown function FOG69_17125 ENOG41067S9 phage shock protein C, PspC FOG69_17130 ENOG4108PY7 FOG69_17145 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOG69_17150 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOG69_17165 ENOG4105MKU Transcriptional regulator FOG69_17195 ENOG4105CN1 protease FOG69_17200 ENOG4108M26 parallel beta-helix repeat protein FOG69_17205 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOG69_17210 ENOG4105CAK Cell division ATP-binding protein ftsE FOG69_17230 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOG69_17235 ENOG4105MS2 ribosomal subunit Interface protein FOG69_17250 ENOG4105MQ3 flagellar protein FliS FOG69_17255 ENOG4107RT6 flagellar hook-associated FOG69_17260 ENOG4105I03 Flagellin FOG69_17265 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FOG69_17270 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FOG69_17280 ENOG4105DTJ flagellar hook-associated protein FOG69_17285 ENOG4105E1Q flagellar hook-associated protein FOG69_17300 ENOG4105RU3 FOG69_17305 ENOG41081UC Inherit from COG: Competence protein FOG69_17325 ENOG4105WH1 Two component transcriptional regulator luxr family FOG69_17330 ENOG4105BZU Histidine kinase FOG69_17335 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOG69_17340 ENOG4108KGH TRANSCRIPTIONal FOG69_17345 ENOG4105ESV Glycosyl transferase, family 4 FOG69_17350 ENOG4107EF8 Glycosyl transferase (Group 1 FOG69_17365 ENOG4105QZI O-Antigen Polymerase FOG69_17370 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOG69_17375 ENOG4107RA4 Glycosyl transferase (Group 1 FOG69_17380 ENOG4105PSV Polysaccharide Biosynthesis Protein FOG69_17385 ENOG4105D3Q Sugar transferase FOG69_17390 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOG69_17395 ENOG4105JFG SpoIID LytB domain protein FOG69_17405 ENOG4108KGH TRANSCRIPTIONal FOG69_17410 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOG69_17415 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOG69_17420 ENOG4105EY8 ABC transporter FOG69_17430 ENOG4107SJB teichoic acid biosynthesis FOG69_17440 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FOG69_17450 ENOG4107RZX Teichoic acid biosynthesis protein FOG69_17460 ENOG4105DG6 mannose-6-phosphate isomerase FOG69_17475 ENOG4108NHD germination protein FOG69_17480 ENOG4108NHD germination protein FOG69_17485 ENOG4108SHN Glycosyl transferase, family 2 FOG69_17490 ENOG4105C54 Major Facilitator superfamily FOG69_17495 ENOG4108KGH TRANSCRIPTIONal FOG69_17500 ENOG4105J7I hydrolase FOG69_17505 ENOG4106UBQ FOG69_17510 ENOG4105K4H Nlp p60 protein FOG69_17525 ENOG4105PNM synthesis protein FOG69_17535 ENOG4105N98 Capsule biosynthesis protein capB FOG69_17545 ENOG4105E1K spore germination protein FOG69_17560 ENOG4105ETE Transcriptional regulator (LacI family FOG69_17565 ENOG4108RVA ribokinase FOG69_17570 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FOG69_17575 ENOG4105C2J ABC transporter FOG69_17580 ENOG4105CNN ABC, transporter FOG69_17585 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOG69_17595 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOG69_17600 ENOG4107FQX Alpha-acetolactate decarboxylase FOG69_17610 ENOG4107RSM transcriptional regulator FOG69_17625 ENOG4106UIA FOG69_17640 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOG69_17650 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOG69_17660 ENOG4105CAH Chromate FOG69_17665 ENOG4105FGV Chromate FOG69_17715 ENOG4108XI2 Domain of unknown function (DUF1963) FOG69_17720 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOG69_17725 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOG69_17730 ENOG4107YJ4 chain length determinant protein FOG69_17735 ENOG4105HTX biosynthesis protein FOG69_17750 ENOG4105KBK Zinc finger, swim domain protein FOG69_17755 ENOG4105C0D helicase FOG69_17760 ENOG410667J hydrolase FOG69_17765 ENOG4105E98 transcriptional regulator DeoR family FOG69_17770 ENOG4105Z8H single-stranded DNA-binding protein FOG69_17785 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FOG69_17790 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOG69_17800 ENOG4105CGA flagellar basal-body rod protein FlgG FOG69_17810 ENOG4105DFF Rod shape-determining protein mreb FOG69_17815 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOG69_17820 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOG69_17825 ENOG4105CZM Major Facilitator FOG69_17830 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FOG69_17840 ENOG4105D3W isochorismatase FOG69_17845 ENOG4105BZU Histidine kinase FOG69_17855 ENOG4105CNI cell division protein FtsW FOG69_17860 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOG69_17870 ENOG4105FRN stage II sporulation protein FOG69_17875 ENOG4107TCE N-acetyltransferase FOG69_17890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOG69_17900 ENOG4106BRK FOG69_17905 ENOG4108RYK Nad-dependent epimerase dehydratase FOG69_17910 ENOG4108Z40 Transcriptional regulator FOG69_17915 ENOG4105CQM Urea amidohydrolase subunit alpha FOG69_17920 ENOG4105KI2 Urea amidohydrolase subunit beta FOG69_17925 ENOG4108YZ9 Urea amidohydrolase subunit gamma FOG69_17945 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOG69_17950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOG69_17955 ENOG4108TF4 von Willebrand factor, type A FOG69_17970 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOG69_17980 ENOG4106778 Protein of unknown function (DUF1146) FOG69_17990 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOG69_17995 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOG69_18000 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOG69_18005 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOG69_18010 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOG69_18025 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOG69_18035 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOG69_18040 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOG69_18045 ENOG4108UIC UPF0340 protein FOG69_18050 ENOG4108YZG isomerase FOG69_18055 ENOG4107WAU Protein tyrosine phosphatase FOG69_18060 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FOG69_18065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOG69_18075 ENOG4108ZXQ stage ii sporulation protein r FOG69_18090 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOG69_18095 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOG69_18100 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOG69_18110 ENOG4107TT2 Auxin Efflux Carrier FOG69_18115 ENOG4105C6K Malic enzyme FOG69_18120 ENOG4107104 thymidine kinase FOG69_18125 ENOG41082DI 50s ribosomal protein l31 FOG69_18130 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOG69_18135 ENOG4105CBT Fructose-1,6-bisphosphatase FOG69_18140 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOG69_18150 ENOG4105D2N Aldolase FOG69_18155 ENOG410812K response regulator receiver protein FOG69_18165 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOG69_18175 ENOG4105DF6 Fe-S oxidoreductase FOG69_18185 ENOG4105E5J UV damage endonuclease FOG69_18195 ENOG4105BZ1 (ABC) transporter FOG69_18200 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOG69_18210 ENOG4105R3A Nitrate reductase FOG69_18215 ENOG4108IUE nitrate reductase beta subunit FOG69_18235 ENOG4107V6Q Cyclic nucleotide-binding domain FOG69_18245 ENOG4105C75 arginyL-tRNA synthetase FOG69_18250 ENOG410684U Domain of unknown function (DUF1934) FOG69_18270 ENOG4107JM4 Tetratricopeptide repeat FOG69_18280 ENOG4105CYW agmatinase FOG69_18285 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOG69_18290 ENOG4105BZ4 penicillin-binding protein FOG69_18300 ENOG4108XFG YwhD family FOG69_18305 ENOG4108Z4T Peptidase M50 FOG69_18310 ENOG41069HH 4-oxalocrotonate tautomerase FOG69_18315 ENOG41067TZ transcriptional regulator, MarR family FOG69_18325 ENOG4105CUB amino acid FOG69_18335 ENOG4105DCI Phosphohydrolase FOG69_18345 ENOG4108VCI transcription factor, rsfa family FOG69_18350 ENOG4105K7K Transcriptional regulator FOG69_18365 ENOG4108TU7 Inherit from COG: (ABC) transporter FOG69_18390 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOG69_18395 ENOG4105DUM transcriptional regulator, lysR family FOG69_18400 ENOG4105HMI Membrane FOG69_18405 ENOG4108IJ2 phosphate acetyltransferase FOG69_18410 ENOG4107JTW chlorite dismutase FOG69_18420 ENOG4105CHM Aminotransferase FOG69_18430 ENOG4108M32 ATP-grasp domain FOG69_18445 ENOG41061WN bacilysin biosynthesis protein FOG69_18450 ENOG4105FCW Major Facilitator superfamily FOG69_18455 ENOG4105C2C drug resistance transporter, Bcr CflA FOG69_18470 ENOG4105C26 Dehydrogenase FOG69_18475 ENOG4105D82 Glutamate dehydrogenase FOG69_18485 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase FOG69_18490 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOG69_18495 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOG69_18500 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOG69_18505 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG FOG69_18510 ENOG4107TY6 Acylneuraminate cytidylyltransferase FOG69_18520 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD FOG69_18525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOG69_18560 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOG69_18565 ENOG4108RJ9 Glycosyl transferase, family 2 FOG69_18575 ENOG4105DWF phosphomethylpyrimidine kinase FOG69_18590 ENOG4105C5Y PTS System FOG69_18605 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOG69_18610 ENOG4105DEN Luciferase family FOG69_18615 ENOG4105D29 Helix-turn-helix type 11 domain protein FOG69_18620 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOG69_18635 ENOG4108DBC nitroreductase FOG69_18645 ENOG4105I4A GCN5-related N-acetyltransferase FOG69_18665 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOG69_18670 ENOG4105E2S oxidase) subunit II FOG69_18675 ENOG4107BMA Transglycosylase associated protein FOG69_18685 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOG69_18690 ENOG4105WH5 Teichoic acid glycosylation protein FOG69_18715 ENOG4107ZXU DSBA oxidoreductase FOG69_18720 ENOG4105DBE peroxidase FOG69_18725 ENOG410650H (LipO)protein FOG69_18730 ENOG4107SJW iron permease, FTR1 FOG69_18735 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOG69_18740 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FOG69_18745 ENOG4105CMU LysR family (Transcriptional regulator FOG69_18750 ENOG4105VAW lrga family FOG69_18755 ENOG41067MG lrgb family FOG69_18765 ENOG4107TXC Transcriptional regulator FOG69_18775 ENOG4105DR4 Methyltransferase FOG69_18785 ENOG4105CK1 PTS System FOG69_18790 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FOG69_18795 ENOG4105X1N Glycosyl transferase family 8 FOG69_18805 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOG69_18825 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FOG69_18830 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOG69_18835 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOG69_18840 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOG69_18845 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOG69_18850 ENOG4105F8D glycoside hydrolase family 4 FOG69_18855 ENOG4105VCP PTS System FOG69_18860 ENOG4105CK1 PTS System FOG69_18865 ENOG4105VZJ PTS System FOG69_18870 ENOG4105EMD TRANSCRIPTIONal FOG69_18885 ENOG4105DQ5 transport system permease protein FOG69_18890 ENOG4105EHG Permease protein FOG69_18900 ENOG41082YX Transcriptional regulator, arsr family FOG69_18905 ENOG4107R5R arsenical pump membrane protein FOG69_18910 ENOG4105VZJ PTS System FOG69_18915 ENOG4105VCP PTS System FOG69_18920 ENOG4105CK1 PTS System FOG69_18925 ENOG4105CS2 ec 3.2.1.21 FOG69_18930 ENOG4105EVU fructokinase FOG69_18935 ENOG4105DG6 mannose-6-phosphate isomerase FOG69_18945 ENOG4105CH6 catalase FOG69_18950 ENOG4107QHE Choloylglycine hydrolase FOG69_18955 ENOG4105ETS cytosine purines uracil thiamine allantoin FOG69_18960 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOG69_18965 ENOG4108JJ8 (ABC) transporter FOG69_18970 ENOG4108JJ9 ABC, transporter FOG69_18975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOG69_18980 ENOG4105C4M (Ubiquinol oxidase) subunit I FOG69_18985 ENOG4105D2K citrate carrier protein FOG69_18990 ENOG4107BJW polysaccharide deacetylase FOG69_19005 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOG69_19015 ENOG4105CMR udp-glucose 4-epimerase FOG69_19020 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOG69_19035 ENOG4105DHI Methyltransferase FOG69_19060 ENOG4105CH6 catalase FOG69_19065 ENOG4105D4T Citrate transporter FOG69_19075 ENOG4105CID antiterminator FOG69_19080 ENOG4105DEU major facilitator superfamily FOG69_19085 ENOG4105C1J atp-dependent rna helicase FOG69_19125 ENOG4108NR7 pectate lyase FOG69_19135 ENOG4107YZX Universal stress protein FOG69_19140 ENOG4105CS2 ec 3.2.1.21 FOG69_19145 ENOG4105C5Y PTS System FOG69_19160 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOG69_19185 ENOG4106Z5D Glycoside Hydrolase Family 43 FOG69_19195 ENOG4105C84 Histidine ammonia-lyase FOG69_19200 ENOG4105CGP Urocanate hydratase FOG69_19205 ENOG4105CI2 imidazolone-5-propionate hydrolase FOG69_19210 ENOG4107W25 arginase agmatinase formiminoglutamase FOG69_19220 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOG69_19225 ENOG4105D9N nucleoside FOG69_19230 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FOG69_19235 ENOG4107RHR regulatoR FOG69_19240 ENOG410667J hydrolase FOG69_19270 ENOG4108V5C ABC transporter FOG69_19305 ENOG4105WZ4 isomerase FOG69_19310 ENOG4105F0H myo-inositol catabolism protein FOG69_19315 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FOG69_19325 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOG69_19335 ENOG4105EDK PfkB domain protein FOG69_19345 ENOG4105C26 Dehydrogenase FOG69_19355 ENOG4105CPC Aldo Keto reductase FOG69_19360 ENOG4107QNK )-transporter FOG69_19365 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOG69_19370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOG69_19375 ENOG4108S01 response regulator FOG69_19380 ENOG4108ZGX Histidine kinase FOG69_19385 ENOG4105ECK Fatty Acid Desaturase FOG69_19395 ENOG4105ST3 Transcriptional regulator FOG69_19400 ENOG4105C26 Dehydrogenase FOG69_19405 ENOG4108ITS PQQ enzyme repeat FOG69_19415 ENOG4105WAB arsR family transcriptional regulator FOG69_19420 ENOG4105F27 Major Facilitator FOG69_19425 ENOG41085PJ rdd domain containing protein FOG69_19435 ENOG4105D3R alkyl hydroperoxide reductase FOG69_19440 ENOG4108JU3 Alkyl hydroperoxide reductase FOG69_19450 ENOG4105C85 amino acid FOG69_19475 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FOG69_19480 ENOG4108XHQ (2Fe-2S)-binding domain protein FOG69_19490 ENOG4105C7W Xanthine dehydrogenase FOG69_19500 ENOG4105XRQ Xanthine dehydrogenase accessory factor FOG69_19530 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOG69_19550 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOG69_19555 ENOG4105CPC Aldo Keto reductase FOG69_19560 ENOG4105WQG acetyltransferase FOG69_19570 ENOG41066UZ arginase EC 3.5.3.1 FOG69_19575 ENOG4108IQI permease FOG69_19580 ENOG4105C8Y Acetylornithine aminotransferase FOG69_19590 ENOG41082BM Transcriptional regulator, arsr family FOG69_19595 ENOG4108JUB Transcriptional regulator FOG69_19610 ENOG41062D9 Histidine kinase FOG69_19615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_19625 ENOG4105C0H protease FOG69_19630 ENOG4105Q2H domain protein FOG69_19645 ENOG4105BZU Histidine kinase FOG69_19650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOG69_19680 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOG69_19685 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOG69_19690 ENOG4105CDU Replicative dna helicase FOG69_19725 ENOG4105CGN Glycosyl transferase (Group 1 FOG69_19745 ENOG4105BZR domain protein FOG69_19750 ENOG4108XMW Membrane FOG69_19765 ENOG4105KVH Transcriptional regulator FOG69_19770 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FOG69_19775 ENOG4108UZ3 Transporter FOG69_19780 ENOG4105EDQ levansucrase EC 2.4.1.10 FOG69_19785 ENOG4108HKT sucrose-6-phosphate hydrolase FOG69_19815 ENOG4108TVJ Nitroreductase FOG69_19820 ENOG4105FS7 Transcriptional regulator FOG69_19830 ENOG4108U05 Transcriptional regulator FOG69_19835 ENOG41082BV acetyltransferase FOG69_19850 ENOG4107Y9U Membrane FOG69_19855 ENOG4105C7Z Conserved Protein FOG69_19860 ENOG4107RRE RNA-directed DNA polymerase FOG69_19865 ENOG4105C7Z Conserved Protein FOG69_19870 ENOG4107FCW Abortive infection protein FOG69_19880 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOG69_19890 ENOG4105CGK Exodeoxyribonuclease III FOG69_19895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOG69_19905 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOG69_19910 ENOG4108UUM single-stranded DNA-binding protein FOG69_19915 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOG69_19920 ENOG4105C3G gtp-binding protein FOG69_19925 ENOG4108J2R molybdopterin oxidoreductase FOG69_19930 ENOG4105VDK protein, conserved in bacteria FOG69_19945 ENOG4108ZDA Sporulation protein YyaC FOG69_19950 ENOG4105FA0 parb-like partition protein FOG69_19955 ENOG4107QJE Chromosome Partitioning Protein FOG69_19970 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FOG69_19975 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOG69_19990 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOG69_20000 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOG69_20005 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOG69_20010 ENOG410848D S4 domain protein YaaA FOG69_20015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOG69_20025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOG69_20030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOG69_20065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOG69_20075 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FOG69_20080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FOG69_20085 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOG69_20090 ENOG4105BZW Glycerate kinase FOG69_20100 ENOG4105ZMH deoxynucleoside kinase FOG69_20110 ENOG4105VRS hydrolase family 18 FOG69_20115 ENOG4105GTG Isochorismatase FOG69_20120 ENOG4108Z6B deaminase FOG69_20130 ENOG4105C6E dna polymerase iii FOG69_20135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FOG69_20140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOG69_20150 ENOG41067KS pro-sigma K processing FOG69_20190 ENOG4105CDW Resistance protein FOG69_20195 ENOG4105CXN decarboxylase FOG69_20200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOG69_20205 ENOG4105X0R protein from nitrogen regulatory protein P-II FOG69_20210 ENOG4105XVJ Protein of unknown function (DUF327) FOG69_20215 ENOG4105FA2 dna polymerase iii FOG69_20220 ENOG4105MA4 psp1 domain protein FOG69_20230 ENOG41060K3 Methyltransferase FOG69_20235 ENOG4105VC4 domain protein FOG69_20240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOG69_20245 ENOG4105KRN Transcriptional regulator, abrb family FOG69_20250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOG69_20255 ENOG4105F8V Hydrolase, tatD family FOG69_20260 ENOG41069ER domain protein FOG69_20270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOG69_20275 ENOG4105XFA sporulation peptidase YabG FOG69_20280 ENOG4105W42 Veg protein FOG69_20285 ENOG4105XEW small acid-soluble spore protein FOG69_20290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOG69_20295 ENOG4105DFT pur operon repressor FOG69_20300 ENOG4105KME endoribonuclease L-psp FOG69_20305 ENOG4105K4W Could be involved in septation (By similarity) FOG69_20310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOG69_20315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOG69_20320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FOG69_20335 ENOG4108JA2 transcriptioN-repair coupling factor FOG69_20340 ENOG4108M14 stage v sporulation protein t FOG69_20350 ENOG4108IY2 MazG family FOG69_20355 ENOG41082I2 s4 domain protein FOG69_20360 ENOG4105VYY sporulation protein yabp FOG69_20375 ENOG41060GV RNA binding s1 domain protein FOG69_20405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOG69_20410 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOG69_20415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOG69_20420 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FOG69_20425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOG69_20430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase FOG69_20435 ENOG4105C6T cysteine synthase FOG69_20440 ENOG4105CRQ synthase (Component I) FOG69_20445 ENOG4105DDQ anthranilate synthase FOG69_20450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOG69_20455 ENOG4105EEI dihydropteroate synthase FOG69_20460 ENOG4105KRF dihydroneopterin aldolase FOG69_20465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOG69_20475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOG69_20480 ENOG4105CRK lysyL-tRNA synthetase