locus-tag class description KSO_000015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) KSO_000030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KSO_000035 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KSO_000050 ENOG4107QJE Chromosome Partitioning Protein KSO_000055 ENOG4105FA0 parb-like partition protein KSO_000060 ENOG4108ZDA Sporulation protein YyaC KSO_000075 ENOG4105VDK protein, conserved in bacteria KSO_000080 ENOG4108J2R molybdopterin oxidoreductase KSO_000085 ENOG4105C3G gtp-binding protein KSO_000090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KSO_000095 ENOG4108UUM single-stranded DNA-binding protein KSO_000100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KSO_000110 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KSO_000115 ENOG4105CGK Exodeoxyribonuclease III KSO_000125 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KSO_000135 ENOG4107FCW Abortive infection protein KSO_000140 ENOG4105C7Z Conserved Protein KSO_000150 ENOG4108IMY Transcriptional regulator KSO_000155 ENOG410847I Transcriptional regulator, BadM Rrf2 family KSO_000165 ENOG4107Y9U Membrane KSO_000175 ENOG4105DTD Dehydrogenase KSO_000180 ENOG4105CMU LysR family (Transcriptional regulator KSO_000205 ENOG4108U05 Transcriptional regulator KSO_000215 ENOG4105FS7 Transcriptional regulator KSO_000220 ENOG4108TVJ Nitroreductase KSO_000240 ENOG4107XBN GntR Family Transcriptional Regulator KSO_000245 ENOG4108HKT sucrose-6-phosphate hydrolase KSO_000250 ENOG4105EDQ levansucrase EC 2.4.1.10 KSO_000255 ENOG4108UZ3 Transporter KSO_000260 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KSO_000265 ENOG4105KVH Transcriptional regulator KSO_000280 ENOG4108XMW Membrane KSO_000285 ENOG4105BZR domain protein KSO_000305 ENOG4105CPK Glycosyl transferase (Group 1 KSO_000310 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KSO_000320 ENOG4107QPH glycogen) synthase KSO_000325 ENOG4105EDW glycosyl transferase, family 39 KSO_000345 ENOG4105CDU Replicative dna helicase KSO_000350 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KSO_000355 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis KSO_000365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KSO_000370 ENOG4105BZU Histidine kinase KSO_000385 ENOG4105Q2H domain protein KSO_000390 ENOG4105C0H protease KSO_000405 ENOG41062D9 Histidine kinase KSO_000410 ENOG4105D06 uba thif-type nad fad binding protein KSO_000425 ENOG4105C5H ABC transporter KSO_000435 ENOG4108JUB Transcriptional regulator KSO_000440 ENOG41082BM Transcriptional regulator, arsr family KSO_000450 ENOG4105C8Y Acetylornithine aminotransferase KSO_000455 ENOG4108IQI permease KSO_000460 ENOG41066UZ arginase EC 3.5.3.1 KSO_000475 ENOG4105WQG acetyltransferase KSO_000480 ENOG4105CPC Aldo Keto reductase KSO_000485 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KSO_000510 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KSO_000525 ENOG4105DQ6 Transposase KSO_000560 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KSO_000570 ENOG4105XRQ Xanthine dehydrogenase accessory factor KSO_000590 ENOG4108XHQ (2Fe-2S)-binding domain protein KSO_000595 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KSO_000600 ENOG4105C85 amino acid KSO_000605 ENOG4108JU3 Alkyl hydroperoxide reductase KSO_000610 ENOG4105D3R alkyl hydroperoxide reductase KSO_000620 ENOG41085PJ rdd domain containing protein KSO_000625 ENOG4105F27 Major Facilitator KSO_000630 ENOG4105WAB arsR family transcriptional regulator KSO_000640 ENOG4108ITS PQQ enzyme repeat KSO_000645 ENOG4105C26 Dehydrogenase KSO_000650 ENOG4105ST3 Transcriptional regulator KSO_000655 ENOG4105ECK Fatty Acid Desaturase KSO_000660 ENOG4108ZGX Histidine kinase KSO_000665 ENOG4108S01 response regulator KSO_000670 ENOG41061TZ Short-chain dehydrogenase reductase Sdr KSO_000680 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) KSO_000685 ENOG4107QNK )-transporter KSO_000690 ENOG4105CPC Aldo Keto reductase KSO_000700 ENOG4105C26 Dehydrogenase KSO_000710 ENOG4105EDK PfkB domain protein KSO_000720 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KSO_000730 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KSO_000735 ENOG4105F0H myo-inositol catabolism protein KSO_000740 ENOG4105WZ4 isomerase KSO_000775 ENOG4108V5C ABC transporter KSO_000805 ENOG410667J hydrolase KSO_000810 ENOG4107RHR regulatoR KSO_000815 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) KSO_000820 ENOG4105D9N nucleoside KSO_000825 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KSO_000835 ENOG4107W25 arginase agmatinase formiminoglutamase KSO_000840 ENOG4105CI2 imidazolone-5-propionate hydrolase KSO_000845 ENOG4105CGP Urocanate hydratase KSO_000850 ENOG4105C84 Histidine ammonia-lyase KSO_000860 ENOG4106Z5D Glycoside Hydrolase Family 43 KSO_000865 ENOG4105M6F mutator MutT protein KSO_000875 ENOG4107YZX Universal stress protein KSO_000885 ENOG4108NR7 pectate lyase KSO_000960 ENOG4105C1J atp-dependent rna helicase KSO_000965 ENOG4105DEU major facilitator superfamily KSO_000990 ENOG4105D4T Citrate transporter KSO_000995 ENOG4105CH6 catalase KSO_001020 ENOG4105DHI Methyltransferase KSO_001050 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KSO_001055 ENOG4105CMR udp-glucose 4-epimerase KSO_001065 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KSO_001080 ENOG4107BJW polysaccharide deacetylase KSO_001085 ENOG4105D2K citrate carrier protein KSO_001090 ENOG4105C4M (Ubiquinol oxidase) subunit I KSO_001095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KSO_001100 ENOG4108JJ9 ABC, transporter KSO_001105 ENOG4108JJ8 (ABC) transporter KSO_001110 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) KSO_001115 ENOG4105ETS cytosine purines uracil thiamine allantoin KSO_001120 ENOG4107QHE Choloylglycine hydrolase KSO_001125 ENOG4105CH6 catalase KSO_001135 ENOG4105DG6 mannose-6-phosphate isomerase KSO_001140 ENOG4105EVU fructokinase KSO_001145 ENOG4105CS2 ec 3.2.1.21 KSO_001150 ENOG4105CK1 PTS System KSO_001155 ENOG4105VCP PTS System KSO_001160 ENOG4105VZJ PTS System KSO_001165 ENOG4107R5R arsenical pump membrane protein KSO_001170 ENOG41082YX Transcriptional regulator, arsr family KSO_001180 ENOG4105EHG Permease protein KSO_001185 ENOG4105DQ5 transport system permease protein KSO_001200 ENOG4105EMD TRANSCRIPTIONal KSO_001205 ENOG4105VZJ PTS System KSO_001210 ENOG4105CK1 PTS System KSO_001215 ENOG4105VCP PTS System KSO_001220 ENOG4105F8D glycoside hydrolase family 4 KSO_001225 ENOG4105CM2 brancheD-chain amino acid aminotransferase KSO_001230 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KSO_001235 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) KSO_001240 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KSO_001245 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) KSO_001255 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KSO_001265 ENOG4105X1N Glycosyl transferase family 8 KSO_001270 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin KSO_001275 ENOG4105CK1 PTS System KSO_001285 ENOG4105DR4 Methyltransferase KSO_001290 ENOG4107TXC Transcriptional regulator KSO_001305 ENOG41067MG lrgb family KSO_001310 ENOG4105VAW lrga family KSO_001315 ENOG4105CMU LysR family (Transcriptional regulator KSO_001320 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase KSO_001325 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KSO_001330 ENOG410650H (LipO)protein KSO_001335 ENOG4105DBE peroxidase KSO_001340 ENOG4107ZXU DSBA oxidoreductase KSO_001365 ENOG4105WH5 Teichoic acid glycosylation protein KSO_001375 ENOG4107BMA Transglycosylase associated protein KSO_001380 ENOG4105E2S oxidase) subunit II KSO_001385 ENOG4105BZ9 Cytochrome C oxidase, subunit I KSO_001405 ENOG4105I4A GCN5-related N-acetyltransferase KSO_001415 ENOG4108DBC nitroreductase KSO_001420 ENOG4105DEN Luciferase family KSO_001425 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin KSO_001440 ENOG4105C5Y PTS System KSO_001455 ENOG4105DWF phosphomethylpyrimidine kinase KSO_001475 ENOG4108RJ9 Glycosyl transferase, family 2 KSO_001480 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KSO_001515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KSO_001520 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD KSO_001530 ENOG4107TY6 Acylneuraminate cytidylyltransferase KSO_001535 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG KSO_001540 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KSO_001545 ENOG4105C1B dTDP-glucose 4-6-dehydratase KSO_001550 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KSO_001555 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase KSO_001565 ENOG4105D82 Glutamate dehydrogenase KSO_001570 ENOG4105C26 Dehydrogenase KSO_001585 ENOG4105C2C drug resistance transporter, Bcr CflA KSO_001590 ENOG4105FCW Major Facilitator superfamily KSO_001620 ENOG4105CHM Aminotransferase KSO_001630 ENOG4107JTW chlorite dismutase KSO_001635 ENOG4108IJ2 phosphate acetyltransferase KSO_001640 ENOG4105HMI Membrane KSO_001645 ENOG4105DUM transcriptional regulator, lysR family KSO_001650 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) KSO_001655 ENOG4105CJ1 ABC, transporter KSO_001665 ENOG4105K7K Transcriptional regulator KSO_001670 ENOG4108VCI transcription factor, rsfa family KSO_001680 ENOG4105DCI Phosphohydrolase KSO_001690 ENOG4105CUB amino acid KSO_001700 ENOG41067TZ transcriptional regulator, MarR family KSO_001705 ENOG41069HH 4-oxalocrotonate tautomerase KSO_001710 ENOG4108Z4T Peptidase M50 KSO_001715 ENOG4108XFG YwhD family KSO_001725 ENOG4105BZ4 penicillin-binding protein KSO_001730 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KSO_001735 ENOG4105CYW agmatinase KSO_001775 ENOG4107JM4 Tetratricopeptide repeat KSO_001780 ENOG410684U Domain of unknown function (DUF1934) KSO_001785 ENOG4105C75 arginyL-tRNA synthetase KSO_001795 ENOG4107V6Q Cyclic nucleotide-binding domain KSO_001815 ENOG4108IUE nitrate reductase beta subunit KSO_001820 ENOG4105R3A Nitrate reductase KSO_001835 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KSO_001840 ENOG4105BZ1 (ABC) transporter KSO_001850 ENOG4105E5J UV damage endonuclease KSO_001860 ENOG4105DF6 Fe-S oxidoreductase KSO_001870 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) KSO_001880 ENOG410812K response regulator receiver protein KSO_001885 ENOG4105D2N Aldolase KSO_001895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KSO_001900 ENOG4105CBT Fructose-1,6-bisphosphatase KSO_001910 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KSO_001915 ENOG41082DI 50s ribosomal protein l31 KSO_001920 ENOG4107104 thymidine kinase KSO_001925 ENOG4105C6K Malic enzyme KSO_001930 ENOG4107TT2 Auxin Efflux Carrier KSO_001940 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KSO_001945 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KSO_001950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KSO_001960 ENOG4108ZXQ stage ii sporulation protein r KSO_001970 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KSO_001975 ENOG410815N Probably functions as a manganese efflux pump (By similarity) KSO_001980 ENOG4107WAU Protein tyrosine phosphatase KSO_001985 ENOG4108YZG isomerase KSO_001990 ENOG4108UIC UPF0340 protein KSO_001995 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KSO_002000 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KSO_002010 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) KSO_002025 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KSO_002030 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KSO_002035 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KSO_002040 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KSO_002045 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KSO_002055 ENOG4106778 Protein of unknown function (DUF1146) KSO_002065 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KSO_002080 ENOG4108TF4 von Willebrand factor, type A KSO_002090 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KSO_002095 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KSO_002115 ENOG4108YZ9 Urea amidohydrolase subunit gamma KSO_002120 ENOG4105KI2 Urea amidohydrolase subunit beta KSO_002125 ENOG4105CQM Urea amidohydrolase subunit alpha KSO_002130 ENOG4108Z40 Transcriptional regulator KSO_002140 ENOG4107T94 Endo-14-beta-xylanase KSO_002150 ENOG4106BRK KSO_002155 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KSO_002175 ENOG4107TCE N-acetyltransferase KSO_002180 ENOG4105FRN stage II sporulation protein KSO_002190 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KSO_002195 ENOG4105CNI cell division protein FtsW KSO_002205 ENOG4105BZU Histidine kinase KSO_002210 ENOG4105D3W isochorismatase KSO_002215 ENOG41080V3 Major Facilitator superfamily KSO_002220 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KSO_002225 ENOG4105CZM Major Facilitator KSO_002230 ENOG4107MII Sugar-specific transcriptional regulator TrmB KSO_002235 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KSO_002240 ENOG4105DFF Rod shape-determining protein mreb KSO_002250 ENOG4105CGA flagellar basal-body rod protein FlgG KSO_002260 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KSO_002265 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KSO_002280 ENOG4105Z8H single-stranded DNA-binding protein KSO_002285 ENOG4105E98 transcriptional regulator DeoR family KSO_002290 ENOG410667J hydrolase KSO_002295 ENOG4105C0D helicase KSO_002300 ENOG4105KBK Zinc finger, swim domain protein KSO_002310 ENOG4105HTX biosynthesis protein KSO_002315 ENOG4107YJ4 chain length determinant protein KSO_002320 ENOG4108RB3 Capsular polysaccharide biosynthesis protein KSO_002330 ENOG4105C6Y Udp-glucose 6-dehydrogenase KSO_002335 ENOG4108XI2 Domain of unknown function (DUF1963) KSO_002375 ENOG4107EV6 Inherit from COG: YD repeat protein KSO_002400 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) KSO_002405 ENOG4107V2S Transcriptional regulator KSO_002410 ENOG4108WS4 fmn reductase KSO_002420 ENOG4105FGV Chromate KSO_002425 ENOG4105CAH Chromate KSO_002435 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KSO_002445 ENOG4107XC4 flavin reductase domain protein, FMN-binding KSO_002460 ENOG4106UIA KSO_002480 ENOG4107RSM transcriptional regulator KSO_002490 ENOG4107FQX Alpha-acetolactate decarboxylase KSO_002495 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KSO_002505 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KSO_002510 ENOG4105CNN ABC, transporter KSO_002515 ENOG4105C2J ABC transporter KSO_002520 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) KSO_002525 ENOG4108RVA ribokinase KSO_002530 ENOG4105ETE Transcriptional regulator (LacI family KSO_002545 ENOG4105E1K spore germination protein KSO_002550 ENOG4105N98 Capsule biosynthesis protein capB KSO_002560 ENOG4105PNM synthesis protein KSO_002570 ENOG4105K4H Nlp p60 protein KSO_002575 ENOG4106UBQ KSO_002580 ENOG4105J7I hydrolase KSO_002585 ENOG4108KGH TRANSCRIPTIONal KSO_002590 ENOG4105C54 Major Facilitator superfamily KSO_002595 ENOG4107R8N Glycosyl transferase, family 2 KSO_002600 ENOG4108NHD germination protein KSO_002615 ENOG4105DG6 mannose-6-phosphate isomerase KSO_002625 ENOG4107RZX Teichoic acid biosynthesis protein KSO_002635 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase KSO_002645 ENOG4107SJB teichoic acid biosynthesis KSO_002655 ENOG4105EY8 ABC transporter KSO_002660 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KSO_002665 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KSO_002680 ENOG4105JFG SpoIID LytB domain protein KSO_002685 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KSO_002690 ENOG4105D3Q Sugar transferase KSO_002695 ENOG4105PSV Polysaccharide Biosynthesis Protein KSO_002700 ENOG4107RA4 Glycosyl transferase (Group 1 KSO_002705 ENOG4105C6Y Udp-glucose 6-dehydrogenase KSO_002710 ENOG4105QZI O-Antigen Polymerase KSO_002725 ENOG4107EF8 Glycosyl transferase (Group 1 KSO_002730 ENOG4105ESV Glycosyl transferase, family 4 KSO_002735 ENOG4108KGH TRANSCRIPTIONal KSO_002740 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KSO_002745 ENOG4105BZU Histidine kinase KSO_002750 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_002770 ENOG41081UC Inherit from COG: Competence protein KSO_002775 ENOG4105RU3 KSO_002790 ENOG4105E1Q flagellar hook-associated protein KSO_002795 ENOG4105DTJ flagellar hook-associated protein KSO_002805 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) KSO_002810 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) KSO_002815 ENOG4105I03 Flagellin KSO_002820 ENOG4107RT6 flagellar hook-associated KSO_002825 ENOG4105MQ3 flagellar protein FliS KSO_002840 ENOG4105MS2 ribosomal subunit Interface protein KSO_002845 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KSO_002850 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KSO_002865 ENOG4105CAK Cell division ATP-binding protein ftsE KSO_002870 ENOG4105CRP Part of the ABC transporter FtsEX involved in KSO_002875 ENOG4108M26 parallel beta-helix repeat protein KSO_002880 ENOG4105CN1 protease KSO_002925 ENOG4105MKU Transcriptional regulator KSO_002940 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KSO_002945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KSO_002960 ENOG4108PY7 KSO_002965 ENOG41067S9 phage shock protein C, PspC KSO_002970 ENOG41086DT Membrane protein of unknown function KSO_002975 ENOG41088CQ domain protein KSO_002980 ENOG4105J7D transcriptional regulator KSO_002985 ENOG4105FDP GntR family transcriptional regulator KSO_002990 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KSO_002995 ENOG4105CE4 GlcNAc 6-P deacetylase KSO_003000 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) KSO_003010 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KSO_003015 ENOG4108S4C acetyltransferase KSO_003025 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) KSO_003030 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KSO_003035 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KSO_003040 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KSO_003045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KSO_003050 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase KSO_003055 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KSO_003060 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KSO_003065 ENOG4105BZ1 (ABC) transporter KSO_003070 ENOG4105GIG KSO_003075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KSO_003080 ENOG4105BZU Histidine kinase KSO_003095 ENOG4105C3M thioredoxin reductase KSO_003105 ENOG4108Z4K mutator MutT protein KSO_003110 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) KSO_003115 ENOG4105CHW UPF0052 protein KSO_003120 ENOG4105CIE May be required for sporulation (By similarity) KSO_003125 ENOG4105KRI phosphocarrier protein (HPr KSO_003130 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KSO_003135 ENOG4105GGE ribonuclease KSO_003140 ENOG4105C5I Dehydrogenase KSO_003145 ENOG4108V2W Carbonate dehydratase KSO_003150 ENOG4105CHH sulfate transporter KSO_003155 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain KSO_003160 ENOG4108URH decarboxylase KSO_003170 ENOG4105C7F AcnD-accessory protein PrpF KSO_003175 ENOG4108KAM Transcriptional regulator KSO_003180 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KSO_003185 ENOG4105ETE Transcriptional regulator (LacI family KSO_003190 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) KSO_003195 ENOG4108HKT sucrose-6-phosphate hydrolase KSO_003215 ENOG4107QQR Sporulation KSO_003245 ENOG4105NI3 Protein of unknown function (DUF3237) KSO_003250 ENOG4105PY6 Phenolic acid decarboxylase KSO_003255 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 KSO_003265 ENOG4105NAE bifunctional deaminase-reductase domain protein KSO_003275 ENOG4105EBR Carboxylesterase KSO_003285 ENOG4105HTX biosynthesis protein KSO_003290 ENOG4108QV3 biosynthesis protein KSO_003300 ENOG4108PQP glycosyl transferase group 1 KSO_003305 ENOG4105K64 Glycosyl transferase, family 2 KSO_003310 ENOG4108KMV Glycosyl transferase (Group 1 KSO_003315 ENOG41068W6 Capsular polysaccharide biosynthesis protein KSO_003320 ENOG4107QRS glycosyltransferase group 2 family protein KSO_003330 ENOG4105K64 Glycosyl transferase, family 2 KSO_003340 ENOG4105D3Q Sugar transferase KSO_003345 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family KSO_003350 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KSO_003355 ENOG4108ZPC Polysaccharide pyruvyl transferase KSO_003365 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_003370 ENOG4105DAA L-lactate KSO_003375 ENOG4105JXH GntR family transcriptional regulator KSO_003380 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KSO_003385 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KSO_003390 ENOG4107QR9 Iron-sulfur cluster binding protein KSO_003400 ENOG4105C6Z Gluconate KSO_003405 ENOG4105CMG Carbohydrate kinase KSO_003410 ENOG4106KNT transcriptional regulator KSO_003415 ENOG410667J hydrolase KSO_003440 ENOG4107RT3 EamA-like transporter family KSO_003445 ENOG4105GZI Transcriptional regulator KSO_003455 ENOG4105DEN Luciferase family KSO_003460 ENOG4105CMD Transcriptional regulator, GntR family KSO_003475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KSO_003485 ENOG4105BZA Phosphoglycerate kinase KSO_003490 ENOG4105CP7 Triose-phosphate isomerase KSO_003495 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KSO_003500 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KSO_003505 ENOG4105IIU Aminopeptidase KSO_003510 ENOG4107QQG Dehydrogenase KSO_003515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KSO_003520 ENOG4108IAJ Nad-dependent epimerase dehydratase KSO_003525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KSO_003540 ENOG4105FJR Lmbe family KSO_003555 ENOG4108W0I acetyltransferase KSO_003560 ENOG4105T65 Membrane-associated protein KSO_003575 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein KSO_003580 ENOG4107HG4 Transcriptional regulator KSO_003585 ENOG4108IJ8 ABC transporter KSO_003590 ENOG4105E90 ABC transporter KSO_003595 ENOG4108HQR Glycine betaine KSO_003600 ENOG4105R40 Glycine betaine carnitine choline KSO_003605 ENOG4107HG4 Transcriptional regulator KSO_003610 ENOG4108IJ8 ABC transporter KSO_003615 ENOG4105E90 ABC transporter KSO_003620 ENOG4108HQR Glycine betaine KSO_003625 ENOG4105R40 Glycine betaine carnitine choline KSO_003630 ENOG4105DA5 (ABC) transporter KSO_003655 ENOG4105KVH Transcriptional regulator KSO_003675 ENOG4105XZU Preprotein translocase, subunit SecG KSO_003685 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KSO_003695 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) KSO_003710 ENOG41067XF inhibitor KSO_003715 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KSO_003720 ENOG4108KSA LysR family transcriptional regulator KSO_003725 ENOG4108XSB acetyltransferase, (GNAT) family KSO_003750 ENOG4105CDA abc transporter atp-binding protein KSO_003755 ENOG4105DEN Luciferase family KSO_003790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KSO_003795 ENOG4105D9R oxidoreductase KSO_003800 ENOG4105VPX protein, conserved in bacteria KSO_003805 ENOG410681U heavy metal transport detoxification protein KSO_003810 ENOG4105C59 p-type ATPase KSO_003815 ENOG4105C59 p-type ATPase KSO_003820 ENOG4107ZQN disulfide bond KSO_003835 ENOG4105EN6 Membrane KSO_003840 ENOG4105EEM helicase KSO_003845 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KSO_003850 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KSO_003860 ENOG4105EEQ Na H antiporter KSO_003875 ENOG4108KYE ABC-2 type transporter KSO_003885 ENOG4105CJ1 ABC, transporter KSO_003890 ENOG4105BZU Histidine kinase KSO_003895 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_003900 ENOG4105E0C molybdate abc transporter KSO_003905 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KSO_003910 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KSO_003915 ENOG4107QZ2 Sulfatase KSO_003920 ENOG4107K5X Membrane-bound metal-dependent hydrolase KSO_003930 ENOG4105D5Q Arginine ornithine antiporter KSO_003935 ENOG4105JQZ Methyltransferase KSO_003945 ENOG4105DQ5 transport system permease protein KSO_003950 ENOG4105EHG Permease protein KSO_003955 ENOG4105E0A ABC, transporter KSO_003965 ENOG4105F0F Oxalate decarboxylase KSO_003975 ENOG4106DF4 Sigma-70, region 4 KSO_003985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KSO_003995 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein KSO_004000 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KSO_004005 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) KSO_004010 ENOG4105EHG Permease protein KSO_004015 ENOG4105E0A ABC, transporter KSO_004020 ENOG4108WBT adenosyltransferase KSO_004035 ENOG41087YS Phage shock protein A KSO_004050 ENOG4105ENE Histidine kinase KSO_004055 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_004080 ENOG4105C9Q fumarate hydratase class II KSO_004085 ENOG41067SE Tetr family transcriptional regulator KSO_004095 ENOG4105F3H Histidine kinase KSO_004105 ENOG4105C0H protease KSO_004110 ENOG4105HUF DNA protection during starvation protein KSO_004115 ENOG4105E1F short-chain dehydrogenase reductase KSO_004130 ENOG4105E0A ABC, transporter KSO_004150 ENOG4105C5Q Transcriptional regulator KSO_004155 ENOG4105C0R drug resistance transporter emrb qaca subfamily KSO_004160 ENOG41067TZ transcriptional regulator, MarR family KSO_004190 ENOG4105CHU acetyl-coa acetyltransferase KSO_004195 ENOG4105C1G acyl-Coa dehydrogenase KSO_004200 ENOG41080E8 Transcriptional regulator, Spx MgsR family KSO_004205 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KSO_004235 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KSO_004240 ENOG4108UMI ABC transporter, permease KSO_004245 ENOG4105D01 (LipO)protein KSO_004260 ENOG4105C3K feS assembly ATPase SufC KSO_004265 ENOG4105JRK feS assembly protein SufD KSO_004270 ENOG4105C9B Cysteine desulfurase KSO_004275 ENOG4108UNV SUF system FeS assembly protein, NifU family KSO_004280 ENOG4105DIW FeS assembly protein SUFB KSO_004285 ENOG41083Q9 chitosanase KSO_004300 ENOG4107VFR oxidoreductase KSO_004305 ENOG4105PKS Excinuclease abc c subunit domain protein KSO_004320 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine KSO_004325 ENOG4105XN3 extracellular solute-binding protein family 1 KSO_004330 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KSO_004335 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KSO_004340 ENOG4108KPW sugar kinase KSO_004345 ENOG4105FDP GntR family transcriptional regulator KSO_004350 ENOG4108IJ9 (ABC) transporter KSO_004355 ENOG4108K8S endonuclease I KSO_004365 ENOG4105C5R Aminotransferase KSO_004380 ENOG4105G9B Transcriptional regulator KSO_004385 ENOG4105CD3 dihydroorotase KSO_004395 ENOG4105I3N Conserved Protein KSO_004405 ENOG4107R8B 5'-nucleotidase KSO_004410 ENOG4108YTE sporulation protein YunB KSO_004415 ENOG4105FAA peptidase M23 KSO_004420 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KSO_004425 ENOG4105MMD transcriptional regulator KSO_004435 ENOG4105D4U had-superfamily hydrolase, subfamily iia KSO_004440 ENOG4108W5N phosphatidylglycerophosphatase a KSO_004450 ENOG4105D6E homoserine dehydrogenase KSO_004455 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) KSO_004460 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) KSO_004465 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KSO_004470 ENOG41083MR nifu domain-containing protein KSO_004485 ENOG4105ZKE UPF0349 protein KSO_004495 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) KSO_004500 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KSO_004505 ENOG4108VHC Short-chain dehydrogenase reductase Sdr KSO_004535 ENOG4105CJ1 ABC, transporter KSO_004550 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) KSO_004565 ENOG4105CEP NADH dehydrogenase KSO_004585 ENOG41069ER domain protein KSO_004595 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KSO_004615 ENOG4105NIV Esterase KSO_004620 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KSO_004625 ENOG4105E4F Isochorismate synthase KSO_004630 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase KSO_004635 ENOG4105WQI isochorismatase KSO_004640 ENOG4105CEY Amp-dependent synthetase and ligase KSO_004645 ENOG4105WQT MbtH domain protein KSO_004655 ENOG4105DCF alanine dehydrogenase KSO_004660 ENOG4108K8K Transcriptional regulator KSO_004695 ENOG410904N short-chain dehydrogenase reductase KSO_004710 ENOG4105C02 permease KSO_004735 ENOG4105DAP Nicotinate phosphoribosyltransferase KSO_004740 ENOG4105D58 Diguanylate phosphodiesterase KSO_004770 ENOG4105BZU Histidine kinase KSO_004780 ENOG4105KA0 thioesterase Superfamily protein KSO_004785 ENOG4105KJM monovalent cation h antiporter subunit g KSO_004795 ENOG4105SC1 monovalent cation H antiporter subunit E KSO_004800 ENOG4108JPZ Monovalent cation H antiporter subunit D KSO_004805 ENOG4108ZE9 Monovalent cation H antiporter subunit C KSO_004810 ENOG4105HC0 Na H antiporter KSO_004815 ENOG4105D65 subunit l KSO_004830 ENOG4105UIB (ABC) transporter KSO_004835 ENOG4108JQ9 ABC transporter KSO_004840 ENOG4105DIH basic membrane KSO_004850 ENOG4108MRH transcriptional regulatory protein KSO_004865 ENOG4105KIR Thiol-disulfide oxidoreductase dcc KSO_004870 ENOG4105BZ4 penicillin-binding protein KSO_004885 ENOG4105Y38 Kinase-associated protein B KSO_004890 ENOG4108HGU Histidine kinase KSO_004895 ENOG4105C87 Aminotransferase class I and II KSO_004905 ENOG4108MUZ hydrolase KSO_004910 ENOG4108ZB6 transcriptional regulator AsnC family KSO_004915 ENOG4105CHM Aminotransferase KSO_004925 ENOG4105WG9 Conserved Protein KSO_004930 ENOG4107QW4 alcohol dehydrogenase KSO_004940 ENOG4105CHJ isochorismatase hydrolase KSO_004950 ENOG4107QYV phosphohexose isomerase KSO_004965 ENOG4107PBV potassium channel KSO_004970 ENOG4107PBV potassium channel KSO_004985 ENOG4105C37 (CBS) domain KSO_004995 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme KSO_005000 ENOG4105EA8 2-Nitropropane dioxygenase KSO_005015 ENOG4105C8Q Methyl-accepting chemotaxis KSO_005020 ENOG4105C8Q Methyl-accepting chemotaxis KSO_005025 ENOG4105C8Q Methyl-accepting chemotaxis KSO_005030 ENOG4105C8Q Methyl-accepting chemotaxis KSO_005035 ENOG4108Z0Z intracellular protease Pfpi family KSO_005040 ENOG4105EE0 oxidoreductase KSO_005050 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KSO_005095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KSO_005100 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KSO_005115 ENOG4105TRT Transcriptional regulator KSO_005120 ENOG4105C26 Dehydrogenase KSO_005125 ENOG4108JB8 alcohol dehydrogenase KSO_005130 ENOG4108VNY MOSC domain protein KSO_005135 ENOG4106DF1 KSO_005145 ENOG4105DZ6 Band 7 protein KSO_005150 ENOG4105N67 Proton-coupled thiamine transporter YuaJ KSO_005165 ENOG4105E4F Isochorismate synthase KSO_005170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KSO_005175 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KSO_005180 ENOG4108IPT Naphthoate synthase KSO_005185 ENOG4105CEY Amp-dependent synthetase and ligase KSO_005190 ENOG4105DTQ mandelate racemase muconate lactonizing KSO_005210 ENOG4105NRA 50s ribosomal protein l31 type b KSO_005215 ENOG4108V2W Carbonate dehydratase KSO_005220 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KSO_005225 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) KSO_005240 ENOG4108RMU ferritin dps family protein KSO_005255 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KSO_005265 ENOG4105D2X ABC transporter substrate-binding protein KSO_005280 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KSO_005290 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KSO_005295 ENOG4105CAQ asparagine synthetase KSO_005300 ENOG4105C85 amino acid KSO_005305 ENOG4108Z0R Transferase KSO_005310 ENOG4105E8V Alpha Beta Hydrolase Fold protein KSO_005320 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KSO_005335 ENOG4105N5T Radical SAM Protein KSO_005350 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KSO_005355 ENOG4105DVE abc transporter atp-binding protein KSO_005375 ENOG4105C19 ABC transporter KSO_005380 ENOG4107R34 abc transporter permease protein KSO_005390 ENOG4105EWM Histidine kinase KSO_005395 ENOG4105C19 ABC transporter KSO_005410 ENOG410605W Major Facilitator KSO_005415 ENOG4105BZU Histidine kinase KSO_005425 ENOG4105C8T Leucyl-tRNA synthetase KSO_005430 ENOG41085GJ domain protein KSO_005445 ENOG4105I1K ABC transporter KSO_005450 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component KSO_005470 ENOG4105C94 Transporter KSO_005475 ENOG4105CBX hi0933 family KSO_005490 ENOG4105YW5 deoR family transcriptional regulator KSO_005505 ENOG4105C7N Xanthine uracil vitamin C permease KSO_005510 ENOG4107QSE Dipeptidase KSO_005515 ENOG4105C6T cysteine synthase KSO_005520 ENOG4107F58 2'-5' rna ligase KSO_005535 ENOG4108V15 phosphotransferase enzyme family KSO_005545 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KSO_005550 ENOG4105C8F Beta-lactamase domain protein KSO_005555 ENOG4105C6K Malic enzyme KSO_005570 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KSO_005585 ENOG4108VDD TRNA binding domain protein KSO_005595 ENOG4105DFU Cell wall formation (By similarity) KSO_005615 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KSO_005620 ENOG4105ETE Transcriptional regulator (LacI family KSO_005625 ENOG4107R0U MotA TolQ exbB proton channel KSO_005630 ENOG4105ER2 Ompa motb domain protein KSO_005635 ENOG4105DGU Histone deacetylase KSO_005640 ENOG4105W87 Cbs domain KSO_005645 ENOG4105F1V Acetoin utilization protein KSO_005655 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KSO_005675 ENOG4108NGU Transcriptional regulator KSO_005700 ENOG4108Z0Z intracellular protease Pfpi family KSO_005710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KSO_005720 ENOG4105C26 Dehydrogenase KSO_005725 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KSO_005735 ENOG4105BZU Histidine kinase KSO_005745 ENOG4105U5Y Transcriptional regulator KSO_005770 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) KSO_005780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KSO_005785 ENOG4105EFZ amidohydrolase KSO_005790 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KSO_005795 ENOG4105D07 Signal peptide peptidase, SppA KSO_005800 ENOG4105VK3 rdd domain containing protein KSO_005810 ENOG4105KBJ sporulation protein ytfj KSO_005815 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KSO_005825 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KSO_005830 ENOG4105EPU Molybdenum cofactor synthesis domain protein KSO_005835 ENOG4105CDH Citrulline--aspartate ligase KSO_005840 ENOG4105CH7 arginosuccinase KSO_005855 ENOG4105E8R UPF0173 metal-dependent hydrolase KSO_005870 ENOG4105SFS phosphoesterase RecJ domain protein KSO_005875 ENOG4106EVM KSO_005885 ENOG4105VV2 KSO_005890 ENOG4105C0B DNA polymerase III (alpha subunit) KSO_005895 ENOG4105C6K Malic enzyme KSO_005900 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) KSO_005905 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) KSO_005910 ENOG4105CTQ phosphohexokinase KSO_005915 ENOG4105CA9 Pyruvate kinase KSO_005920 ENOG4105FS0 cytoplasmic membrane protein KSO_005925 ENOG4108REF Sporulation integral membrane protein ytvi KSO_005935 ENOG4105G7B Protein of unknown function (DUF2992) KSO_005940 ENOG4105BZN citrate synthase KSO_005945 ENOG4108HMX isocitrate dehydrogenase (NADP) KSO_005960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KSO_005965 ENOG4105BZU Histidine kinase KSO_005970 ENOG4105C2M dna polymerase I KSO_005975 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KSO_005985 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KSO_005990 ENOG4105CV8 reductase KSO_005995 ENOG4105F27 Major Facilitator KSO_006000 ENOG4105KVH Transcriptional regulator KSO_006005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KSO_006010 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KSO_006040 ENOG4108TDW sporulation protein YtxC KSO_006045 ENOG4105C22 threonyL-tRNA synthetase KSO_006050 ENOG4105U0R haloacid dehalogenase-like hydrolase KSO_006060 ENOG4108HRK Histidine kinase KSO_006065 ENOG4105DY9 regulatoR KSO_006075 ENOG41067MG lrgb family KSO_006080 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KSO_006085 ENOG4105VJV 50s ribosomal protein L35 KSO_006090 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KSO_006105 ENOG4105CN9 Peptidase m42 family protein KSO_006115 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase KSO_006125 ENOG4105EF1 ribulokinase KSO_006130 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase KSO_006140 ENOG4108MDK Dehydrogenase KSO_006155 ENOG4105DRS transport system, permease KSO_006160 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KSO_006170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KSO_006175 ENOG4105CQB FAD linked oxidase domain protein KSO_006185 ENOG41067MF small acid-soluble spore protein KSO_006190 ENOG4108RWN rrna methyltransferase KSO_006195 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KSO_006200 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KSO_006205 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KSO_006220 ENOG4105DCG PHP domain protein KSO_006225 ENOG4105C98 muts2 protein KSO_006235 ENOG4108YV3 Protein of unknown function (DUF2711) KSO_006240 ENOG4105CEY Amp-dependent synthetase and ligase KSO_006245 ENOG4107Z3H Transcriptional regulator, TetR family KSO_006250 ENOG41060WC Enoyl-CoA hydratase KSO_006255 ENOG4105BZJ Electron transfer flavoprotein KSO_006260 ENOG4105C10 Electron transfer flavoprotein KSO_006265 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KSO_006270 ENOG4105K63 Thioredoxin KSO_006275 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KSO_006280 ENOG4105CFH Aspartokinase KSO_006290 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KSO_006300 ENOG4105E33 succinate dehydrogenase KSO_006310 ENOG4105PFC Transcriptional regulator KSO_006315 ENOG41067TZ transcriptional regulator, MarR family KSO_006320 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KSO_006325 ENOG4108XJQ germination protein KSO_006330 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KSO_006335 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KSO_006340 ENOG4105M59 Phosphodiesterase, mj0936 family KSO_006365 ENOG4105C7K acetolactate synthase KSO_006370 ENOG4108ZP8 Acetolactate synthase small subunit KSO_006375 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KSO_006385 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KSO_006390 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KSO_006395 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KSO_006410 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KSO_006415 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KSO_006420 ENOG4108IUQ atp-dependent protease KSO_006425 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KSO_006430 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KSO_006440 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) KSO_006450 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KSO_006460 ENOG4105D52 delta-aminolevulinic acid dehydratase KSO_006465 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KSO_006470 ENOG41068KH stage VI sporulation protein D KSO_006475 ENOG4106AR7 Spore coat protein KSO_006485 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KSO_006490 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KSO_006495 ENOG4106A3R peptidase KSO_006505 ENOG4108Z03 MAF-like protein KSO_006510 ENOG4105W5Q DNA repair protein (RadC KSO_006515 ENOG4105DFF Rod shape-determining protein mreb KSO_006520 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KSO_006525 ENOG4105YHC Rod shape-determining protein MreD KSO_006530 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KSO_006535 ENOG4107QMS site-determining protein KSO_006550 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KSO_006555 ENOG4105X36 (ribosomal) protein KSO_006560 ENOG4105K46 50S ribosomal protein l27 KSO_006575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KSO_006585 ENOG4105CQC Prephenate dehydratase KSO_006600 ENOG4108IYU L-aspartate oxidase KSO_006605 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KSO_006610 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KSO_006615 ENOG4106678 morphogenetic protein associated with SpoVID KSO_006635 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KSO_006640 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KSO_006645 ENOG41061AI Protein of unknown function (DUF2905) KSO_006650 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) KSO_006655 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) KSO_006660 ENOG4105VIE preprotein translocase, subunit YajC KSO_006665 ENOG4105NAP KSO_006670 ENOG4108QG2 Membrane KSO_006675 ENOG4105CKP Polysaccharide Biosynthesis Protein KSO_006685 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KSO_006690 ENOG4105NCW Trka-c domain protein KSO_006695 ENOG41067VP Protein of unknown function (DUF1049) KSO_006700 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) KSO_006710 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KSO_006715 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) KSO_006720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KSO_006735 ENOG4105CUT histidyl-tRNA synthetase KSO_006740 ENOG4105C9M aspartyl-trna synthetase KSO_006745 ENOG4105CUZ uba thif-type nad fad binding protein KSO_006750 ENOG4105D1H recombination factor protein RarA KSO_006760 ENOG4105C3J Cysteine desulfurase KSO_006765 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KSO_006775 ENOG4105C7H Helicase, RecD TraA family KSO_006785 ENOG41060CR KSO_006795 ENOG4105DRP amino acid AbC transporter KSO_006800 ENOG4105EAD ABC transporter KSO_006805 ENOG4105CT1 (ABC) transporter KSO_006810 ENOG4105CDA abc transporter atp-binding protein KSO_006815 ENOG4105C02 permease KSO_006820 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KSO_006825 ENOG4105VBH UPF0297 protein KSO_006830 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KSO_006840 ENOG4105HHA aminodeoxychorismate lyase KSO_006845 ENOG4108VQJ O-methyltransferase KSO_006850 ENOG4105XYU peptidase (U32 family) KSO_006855 ENOG4105CFP Peptidase U32 KSO_007005 ENOG410682Q Phage transcriptional regulator, ArpU KSO_007105 ENOG4108FKH Transglycosylase SLT domain KSO_007115 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KSO_007125 ENOG41068G1 KSO_007145 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KSO_007165 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KSO_007170 ENOG4107XRG penicillin-binding protein KSO_007200 ENOG4105C28 cystathionine KSO_007215 ENOG4108JB9 formate dehydrogenase KSO_007220 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KSO_007225 ENOG4105TMB Formate nitrite transporter KSO_007245 ENOG41082JN Transcriptional regulator KSO_007250 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KSO_007255 ENOG4105D94 Major Facilitator Superfamily KSO_007260 ENOG4107RSM transcriptional regulator KSO_007265 ENOG4108Z66 YbaK ebsC protein KSO_007285 ENOG4105DM4 PTS System KSO_007290 ENOG4105DG6 mannose-6-phosphate isomerase KSO_007300 ENOG4108HCJ Hydrolase KSO_007305 ENOG4105DQF Hydrolase KSO_007320 ENOG4108U7W acetyltransferase KSO_007325 ENOG4108J8C transporter major facilitator family protein KSO_007335 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KSO_007345 ENOG41086D8 Transcriptional regulator KSO_007360 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_007370 ENOG41080BT SNARE associated Golgi KSO_007395 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KSO_007400 ENOG4105CQW ribosome biogenesis GTPase YqeH KSO_007405 ENOG4105E2X shikimate dehydrogenase KSO_007410 ENOG410812S Rna-binding protein KSO_007415 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KSO_007420 ENOG4108WF2 Metal Dependent Phosphohydrolase KSO_007430 ENOG4108D32 Methyltransferase KSO_007440 ENOG4105KQC Competence protein KSO_007445 ENOG4108UK2 deaminase KSO_007450 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KSO_007455 ENOG4105TQK DNA polymerase iii, delta' subunit KSO_007460 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) KSO_007465 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) KSO_007470 ENOG4108ZRV stage ii sporulation protein p KSO_007480 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) KSO_007485 ENOG4105CSA Coproporphyrinogen iii oxidase KSO_007490 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KSO_007495 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KSO_007500 ENOG4105CFG Acts as a chaperone (By similarity) KSO_007505 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) KSO_007510 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KSO_007515 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KSO_007520 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KSO_007535 ENOG4105KTH gatB Yqey KSO_007540 ENOG4105F7J membrane-bound serine protease KSO_007545 ENOG4105DI5 UPF0365 protein KSO_007555 ENOG41068P3 sporulation protein YqfC KSO_007560 ENOG4105EI1 sporulation protein yqfd KSO_007565 ENOG4105C9A Phoh family KSO_007570 ENOG4105CTJ Metal Dependent Phosphohydrolase KSO_007575 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) KSO_007580 ENOG4107YR5 Diacylglycerol kinase KSO_007585 ENOG4105KG3 cytidine deaminase KSO_007590 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KSO_007600 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) KSO_007605 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit KSO_007610 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KSO_007620 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) KSO_007625 ENOG4108UPT UPF0178 protein KSO_007630 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KSO_007635 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_007650 ENOG4105EGD dinuclear metal center protein, YbgI family KSO_007655 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KSO_007670 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) KSO_007675 ENOG41069ZM Protein of unknown function (DUF2624) KSO_007680 ENOG4108JYZ YitT family KSO_007685 ENOG4105N80 Ferric uptake regulator, Fur family KSO_007690 ENOG4108U5J '-nucleotidase KSO_007695 ENOG41063Y9 KSO_007700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KSO_007715 ENOG4105SXS Protein of unknown function (DUF456) KSO_007720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KSO_007730 ENOG4107RF6 penicillin-binding protein KSO_007735 ENOG4105CVA phosphate KSO_007740 ENOG4105C8U phosphate abc transporter KSO_007745 ENOG4105E2Z phosphate ABC transporter (Permease KSO_007750 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KSO_007755 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KSO_007760 ENOG41068DG YceG-like family KSO_007770 ENOG4105WDJ 50S ribosomal protein L33 KSO_007775 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KSO_007820 ENOG4105C5X domain protein KSO_007840 ENOG4105C37 (CBS) domain KSO_007900 ENOG4105VFR signal peptidase KSO_007910 ENOG4108IMY Transcriptional regulator KSO_007925 ENOG4105C0D helicase KSO_007930 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KSO_007940 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KSO_007945 ENOG4105WZW rhodanese family KSO_007950 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KSO_007970 ENOG4105CBJ Metal-dependent enzyme KSO_007980 ENOG4105DC7 peptidase M24 KSO_007985 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KSO_007995 ENOG4105CD2 stage iii sporulation protein aa KSO_008000 ENOG4105KR5 Stage iii sporulation protein KSO_008005 ENOG4108CQH stage III sporulation protein AC KSO_008010 ENOG4105KQ4 Stage iii sporulation protein ad KSO_008020 ENOG410644B Stage III sporulation protein af KSO_008040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KSO_008045 ENOG4108ZSR alkaline shock protein KSO_008055 ENOG4105M7K Involved in the transcription termination process (By similarity) KSO_008060 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KSO_008065 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KSO_008070 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KSO_008075 ENOG4105CTB Polyprenyl synthetase KSO_008080 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) KSO_008085 ENOG4105DX0 Hemolysin A KSO_008090 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) KSO_008095 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KSO_008100 ENOG4105S1Z Stage IV sporulation protein B KSO_008105 ENOG4107QQR Sporulation KSO_008110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KSO_008125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KSO_008160 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KSO_008165 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KSO_008175 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KSO_008180 ENOG4105C1G acyl-Coa dehydrogenase KSO_008190 ENOG4105DXD 2-methylcitrate dehydratase KSO_008195 ENOG4105CR4 methylisocitrate lyase KSO_008200 ENOG4106CCJ Protein of unknown function (DUF2627) KSO_008205 ENOG4108JUB Transcriptional regulator KSO_008215 ENOG4107RDP Dehydrogenase KSO_008220 ENOG4105CKM Branched-chain carboxylic acid kinase KSO_008235 ENOG4105CPP Dehydrogenase, E1 component KSO_008240 ENOG4105C7S Dehydrogenase KSO_008245 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KSO_008250 ENOG4108Y6J UPF0403 protein KSO_008255 ENOG4108HW3 (ABC) transporter KSO_008260 ENOG4105E5Q amino acid AbC transporter KSO_008265 ENOG4105CDA abc transporter atp-binding protein KSO_008270 ENOG4108QEG Membrane KSO_008275 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KSO_008280 ENOG4108ZVT methylmalonyl-coA epimerase KSO_008285 ENOG4108HNZ carboxyl transferase KSO_008290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KSO_008295 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) KSO_008305 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KSO_008310 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KSO_008315 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KSO_008320 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KSO_008325 ENOG410861F 50S ribosomal protein L33 KSO_008335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KSO_008345 ENOG4108K70 Transcriptional regulator KSO_008350 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KSO_008355 ENOG4107QKG PfaD family KSO_008370 ENOG4105CEY Amp-dependent synthetase and ligase KSO_008375 ENOG4105CHR reductase KSO_008385 ENOG4105C0W non-ribosomal peptide synthetase KSO_008395 ENOG4105C0W non-ribosomal peptide synthetase KSO_008400 ENOG4105C0W non-ribosomal peptide synthetase KSO_008415 ENOG4106A3M Cytochrome p-450 KSO_008420 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KSO_008425 ENOG4108KQ6 Enoyl-CoA hydratase KSO_008430 ENOG4105II7 pyrroline-5-carboxylate reductase KSO_008435 ENOG41069FQ Metallo-beta-lactamase superfamily KSO_008440 ENOG4108IXY short-chain dehydrogenase reductase KSO_008450 ENOG4105CS9 pantothenic acid kinase KSO_008455 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase KSO_008465 ENOG4105C02 permease KSO_008480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KSO_008485 ENOG4108XET gCN5-related N-acetyltransferase KSO_008490 ENOG4105KAC Antibiotic biosynthesis monooxygenase KSO_008495 ENOG4105RHY Pfam:UPF0157 KSO_008500 ENOG4106HZJ KSO_008520 ENOG4105CPC Aldo Keto reductase KSO_008530 ENOG4108YZ4 nudix hydrolase KSO_008540 ENOG4108IMY Transcriptional regulator KSO_008545 ENOG4105HDK L-asparaginase KSO_008550 ENOG4108IJ0 Aspartate ammonia-lyase KSO_008555 ENOG4105DFD Na H antiporter KSO_008575 ENOG4105MZ9 stage II sporulation protein m KSO_008580 ENOG4105I3K Ferric uptake regulator, Fur family KSO_008590 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KSO_008595 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) KSO_008600 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) KSO_008610 ENOG4105DZ1 carboxypeptidase KSO_008615 ENOG41082AN stage II sporulation protein KSO_008620 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KSO_008625 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_008640 ENOG41090VF Stage v sporulation protein ac KSO_008645 ENOG4105CZ3 stage V sporulation protein ad KSO_008655 ENOG4105G6R Stage v sporulation protein ae KSO_008665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KSO_008670 ENOG4105PTM secreted protein KSO_008675 ENOG4107ZE5 PPIases accelerate the folding of proteins KSO_008700 ENOG4108R6K riboflavin synthase, subunit alpha KSO_008705 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KSO_008710 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KSO_008735 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KSO_008740 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KSO_008750 ENOG4105DZ1 carboxypeptidase KSO_008755 ENOG4108JIC nucleoside recognition domain protein KSO_008765 ENOG4105FE9 pseudouridine synthase KSO_008775 ENOG4107TWT Cytochrome c biogenesis protein KSO_008780 ENOG4105CRE cytochrome C KSO_008785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KSO_008790 ENOG4105BZU Histidine kinase KSO_008805 ENOG4108JQ1 Dehydrogenase KSO_008810 ENOG4108SAX Membrane KSO_008820 ENOG4105T7X KSO_008825 ENOG4105C9U ATP-dependent DNA helicase RecQ KSO_008830 ENOG4105I7S Abortive infection protein KSO_008845 ENOG4107RGJ metallophosphoesterase KSO_008860 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KSO_008865 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) KSO_008875 ENOG4105MSI germination protein ypeb KSO_008890 ENOG4105CAT Cytidine monophosphate kinase KSO_008895 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KSO_008920 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KSO_008925 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KSO_008940 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KSO_008945 ENOG4105K70 DNA-binding protein KSO_008950 ENOG4105EUJ GTP cyclohydrolase i KSO_008955 ENOG4105WP2 Tryptophan RNA-binding attenuator protein KSO_008960 ENOG4105XXQ heptaprenyl diphosphate synthase component I KSO_008965 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KSO_008970 ENOG4105EAH synthase KSO_008975 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KSO_008980 ENOG4105BZU Histidine kinase KSO_008985 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KSO_008995 ENOG4105KHN chorismate mutase KSO_009000 ENOG4105CRQ synthase (Component I) KSO_009010 ENOG4105DK0 Indole-3-glycerol phosphate synthase KSO_009015 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KSO_009020 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KSO_009030 ENOG4105CIH Imidazole acetol-phosphate transaminase KSO_009040 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KSO_009045 ENOG41068YB TPR repeat-containing protein KSO_009065 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KSO_009085 ENOG4105F0F Oxalate decarboxylase KSO_009090 ENOG4108JYZ YitT family KSO_009095 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KSO_009100 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) KSO_009105 ENOG4108Z5K methylglyoxal synthase KSO_009110 ENOG4105FJR Lmbe family KSO_009115 ENOG4105CPK Glycosyl transferase (Group 1 KSO_009120 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate KSO_009130 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KSO_009140 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) KSO_009145 ENOG4105DVT helicase KSO_009150 ENOG4105YAC KSO_009160 ENOG4105CHM Aminotransferase KSO_009165 ENOG4105C5S asparaginyl-tRNA synthetase KSO_009175 ENOG4105CSM endonuclease III KSO_009185 ENOG4105BZ4 penicillin-binding protein KSO_009190 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KSO_009235 ENOG4108I5C dEAD DEAH box helicase KSO_009240 ENOG4107X2U Inherit from COG: Exonuclease-like protein KSO_009250 ENOG4108UKS UPF0398 protein KSO_009255 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) KSO_009260 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KSO_009280 ENOG4105DVT helicase KSO_009285 ENOG4105CTD carboxy-peptidase KSO_009290 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) KSO_009295 ENOG4105C2W permease KSO_009335 ENOG41065KQ synthase KSO_009345 ENOG410890F Dynamin family KSO_009370 ENOG41081VK Ribonuclease KSO_009410 ENOG4105CVG Homoserine O-transsuccinylase KSO_009415 ENOG4108V06 Glutathione peroxidase KSO_009430 ENOG4105C01 Dihydroxy-acid dehydratase KSO_009435 ENOG4108Y6J UPF0403 protein KSO_009440 ENOG4107YX5 Pfam:DUF548 KSO_009450 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KSO_009455 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KSO_009465 ENOG4108UT2 hemolysin iii KSO_009475 ENOG4105C7B Threonine dehydratase KSO_009485 ENOG4108KF3 Electron transport protein SCO1 SenC KSO_009490 ENOG41090WU lipolytic protein G-D-S-L family KSO_009495 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) KSO_009505 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KSO_009510 ENOG4105E0X reductase KSO_009515 ENOG4105C5E polysaccharide biosynthesis protein KSO_009555 ENOG4105FTQ Dna gyrase KSO_009560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KSO_009575 ENOG4107S4Y M20 DapE family protein YgeY KSO_009580 ENOG4108TSC N-acetyltransferase KSO_009585 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KSO_009620 ENOG410841Q phosphoesterase PA-phosphatase related protein KSO_009625 ENOG4106Z5R KSO_009635 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KSO_009640 ENOG4108VXD carboxy-peptidase KSO_009660 ENOG4108S3Y transcriptional regulator KSO_009665 ENOG4105CS2 ec 3.2.1.21 KSO_009680 ENOG4105E1V na solute symporter KSO_009695 ENOG4105FBA Phospholipase Carboxylesterase KSO_009715 ENOG41090U3 tautomerase KSO_009730 ENOG4105FR1 rard protein KSO_009750 ENOG4106SCS STAS domain KSO_009755 ENOG4107QMU Mate efflux family protein KSO_009770 ENOG41087PP glycosyltransferase MGT family KSO_009780 ENOG4105K4H Nlp p60 protein KSO_009790 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KSO_009795 ENOG4107T89 von Willebrand factor, type A KSO_009800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 KSO_009805 ENOG4105C7S Dehydrogenase KSO_009815 ENOG4105C09 Bile acid KSO_009820 ENOG4105C8J )-transporter KSO_009825 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KSO_009830 ENOG4105EWU Squalene--hopene cyclase KSO_009835 ENOG4105C26 Dehydrogenase KSO_009880 ENOG4105SCY DNAK suppressor KSO_009885 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KSO_009895 ENOG4105C9U ATP-dependent DNA helicase RecQ KSO_009900 ENOG41069ER domain protein KSO_009925 ENOG4108SJC Membrane KSO_009940 ENOG4105KTU Transcriptional regulator, arsr family KSO_009950 ENOG4108W8B Beta-lactamase domain protein KSO_009960 ENOG4105FTV AraC Family Transcriptional Regulator KSO_009965 ENOG4108Z7R Chaperone CsaA KSO_009980 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr KSO_010000 ENOG4108J2R molybdopterin oxidoreductase KSO_010005 ENOG4108M3J Dehydrogenase KSO_010010 ENOG4107U6E carbohydrate kinase FGGY KSO_010015 ENOG4105IE8 Alpha-ketoglutarate permease KSO_010020 ENOG4108UB7 KSO_010045 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KSO_010050 ENOG4105C5Q Transcriptional regulator KSO_010055 ENOG4105CBC glutamate synthase KSO_010060 ENOG4105BZ8 glutamate synthase KSO_010070 ENOG4105CB2 alcohol dehydrogenase KSO_010075 ENOG4108KSA LysR family transcriptional regulator KSO_010085 ENOG4105WAB arsR family transcriptional regulator KSO_010090 ENOG4108RWP Major Facilitator Superfamily protein KSO_010095 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KSO_010120 ENOG4107QJQ Mate efflux family protein KSO_010125 ENOG4108N2V aldose 1-epimerase KSO_010130 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family KSO_010135 ENOG4105C0W non-ribosomal peptide synthetase KSO_010145 ENOG4105C0W non-ribosomal peptide synthetase KSO_010150 ENOG4105CEY Amp-dependent synthetase and ligase KSO_010160 ENOG4106U2H Protein of unknown function (DUF1360) KSO_010165 ENOG4105F32 YngK protein KSO_010170 ENOG4105C1G acyl-Coa dehydrogenase KSO_010175 ENOG4105CEY Amp-dependent synthetase and ligase KSO_010180 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KSO_010185 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KSO_010190 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KSO_010195 ENOG4105E39 Enoyl-CoA hydratase KSO_010200 ENOG4107QX3 carboxylase KSO_010205 ENOG4107T5V SNARE associated Golgi KSO_010210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KSO_010220 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) KSO_010225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KSO_010230 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KSO_010235 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) KSO_010240 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KSO_010245 ENOG4106A3M Cytochrome p-450 KSO_010250 ENOG4105CY2 Citrate transporter KSO_010255 ENOG4105D6N CoA-transferase, subunit a KSO_010260 ENOG4108IIH CoA-transferase subunit B KSO_010265 ENOG4105DTD Dehydrogenase KSO_010290 ENOG4107SYN Glycosyl hydrolases family 43 KSO_010300 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KSO_010330 ENOG4105FVX KSO_010345 ENOG4108I5G Major Facilitator superfamily KSO_010355 ENOG4105DMW Dehydrogenase reductase KSO_010370 ENOG4108UHU Aldolase KSO_010375 ENOG4105CPQ Dehydrogenase KSO_010405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KSO_010410 ENOG4105K4P CoA-binding domain protein KSO_010415 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KSO_010420 ENOG4105W8X HesB YadR YfhF-family protein KSO_010425 ENOG4105MI2 KSO_010435 ENOG41067CD Small, acid-soluble spore protein Tlp KSO_010450 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KSO_010455 ENOG4108I0Z Aconitate hydratase KSO_010490 ENOG4107QIV Cytochrome c biogenesis protein KSO_010500 ENOG4105VXM UPF0154 protein KSO_010510 ENOG4105CV1 Transketolase (EC 2.2.1.1) KSO_010515 ENOG4105VPS UPF0291 protein KSO_010520 ENOG4108SVB resolvase KSO_010530 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KSO_010555 ENOG4105K7W phage-related replication protein KSO_010560 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KSO_010580 ENOG41068WN KSO_010590 ENOG4108M1A Chitin-binding protein KSO_010615 ENOG4105EPI acetyltransferase, (GNAT) family KSO_010635 ENOG4105DQ4 alcohol dehydrogenase KSO_010645 ENOG4105D29 Helix-turn-helix type 11 domain protein KSO_010665 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KSO_010670 ENOG4105CMG Carbohydrate kinase KSO_010675 ENOG4105C93 Xylose Isomerase KSO_010685 ENOG4105DSG hydrolase family 43 KSO_010690 ENOG4105CT4 transporter KSO_010700 ENOG4105C5F glutamine synthetase KSO_010705 ENOG4105KV4 Transcriptional regulator KSO_010710 ENOG4105CXI aluminum resistance protein KSO_010715 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KSO_010720 ENOG4106F1P AAA ATPase, central domain protein KSO_010730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KSO_010735 ENOG4105U6W MutT NUDIX family protein KSO_010740 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KSO_010745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KSO_010770 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) KSO_010795 ENOG4108X3M OsmC Ohr family protein KSO_010800 ENOG4105K7W phage-related replication protein KSO_010810 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KSO_010820 ENOG4105XPP Protein of unknown function (DUF1275) KSO_010825 ENOG4105WFK nuclease KSO_010830 ENOG4106A3M Cytochrome p-450 KSO_010840 ENOG4105C0W non-ribosomal peptide synthetase KSO_010850 ENOG4107SQU synthase KSO_010855 ENOG4105C0W non-ribosomal peptide synthetase KSO_010860 ENOG4108KQ6 Enoyl-CoA hydratase KSO_010865 ENOG4108MGH Enoyl-CoA hydratase KSO_010870 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KSO_010875 ENOG41062T2 Acyl carrier protein KSO_010880 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KSO_010885 ENOG4108JA1 polyketide synthase KSO_010890 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KSO_010895 ENOG4108151 Beta-lactamase domain protein KSO_010905 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KSO_010925 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KSO_010930 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KSO_010935 ENOG4105CPQ Dehydrogenase KSO_010940 ENOG4105MCT stage V sporulation protein S KSO_010945 ENOG4105D48 metallophosphoesterase KSO_010955 ENOG4108A04 Beta-lactamase KSO_010960 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) KSO_010965 ENOG4105CEV competence damage-inducible protein KSO_010970 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KSO_010985 ENOG4105XZV Protein of unknown function (DUF3243) KSO_010990 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KSO_011005 ENOG4105EYF MMPL domain protein KSO_011020 ENOG4105FDP GntR family transcriptional regulator KSO_011025 ENOG4105CNU cell division protein FtsK KSO_011035 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KSO_011045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KSO_011055 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KSO_011060 ENOG4108S0H Dipicolinic acid synthetase, b subunit KSO_011065 ENOG4105E35 Dipicolinate synthase subunit A KSO_011075 ENOG4105C1V Peptidase, M16 KSO_011085 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KSO_011090 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KSO_011095 ENOG4105DTN riboflavin biosynthesis protein ribF KSO_011100 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KSO_011105 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KSO_011110 ENOG4105W7A Protein of unknown function (DUF503) KSO_011115 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KSO_011120 ENOG4105VHM ribosomal protein KSO_011125 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KSO_011130 ENOG4105CHV Transcription elongation factor NusA KSO_011135 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KSO_011140 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KSO_011145 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KSO_011150 ENOG4105DZP Membrane-associated zinc metalloprotease KSO_011160 ENOG4105KNE Phosphatidate cytidylyltransferase KSO_011165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KSO_011170 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KSO_011175 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) KSO_011185 ENOG4105CE9 30S ribosomal protein S2 KSO_011195 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_011200 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) KSO_011210 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis KSO_011215 ENOG4105CBS Chea signal transduction histidine kinase KSO_011220 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KSO_011230 ENOG4105FZW flagellar biosynthesis regulator FlhF KSO_011235 ENOG4105D7B Flagellar biosynthesis protein flha KSO_011240 ENOG4105D00 flagellar biosynthetic protein flhB KSO_011245 ENOG4105D19 Role in flagellar biosynthesis (By similarity) KSO_011250 ENOG4105VS8 Flagellar biosynthetic protein fliq KSO_011255 ENOG4105CN7 Flagellar biosynthetic protein FliP KSO_011265 ENOG4107YTP response regulator receiver protein KSO_011270 ENOG4105DD5 Flagellar motor switch protein KSO_011275 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KSO_011285 ENOG41068WV flagellar FlbD family protein KSO_011290 ENOG4108JQA flagellar KSO_011295 ENOG410822I Flagellar hook capping protein KSO_011300 ENOG410696Y Flagellar hook-length control protein KSO_011310 ENOG4106YF4 Flagellar biosynthesis chaperone KSO_011325 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KSO_011330 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KSO_011335 ENOG4105VQ0 flagellar hook-basal body complex protein fliE KSO_011340 ENOG4108ZC9 flagellar basal-body rod protein flgc KSO_011345 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) KSO_011355 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KSO_011360 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KSO_011365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KSO_011370 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) KSO_011375 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KSO_011385 ENOG4105C79 DNA protecting protein DprA KSO_011390 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KSO_011395 ENOG4105CMV Succinyl-CoA synthetase subunit beta KSO_011400 ENOG4105VM1 flagellar KSO_011410 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KSO_011415 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KSO_011420 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KSO_011425 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KSO_011440 ENOG4108BW8 UPF0109 protein KSO_011445 ENOG4105K5M 30s ribosomal protein S16 KSO_011455 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) KSO_011465 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KSO_011470 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) KSO_011475 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KSO_011480 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) KSO_011485 ENOG4105CHR reductase KSO_011490 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KSO_011495 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) KSO_011500 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) KSO_011505 ENOG4105CB5 ATP-dependent DNA helicase recG KSO_011510 ENOG4105EJQ L-serine dehydratase KSO_011520 ENOG4105DP4 dak2 domain fusion protein ylov KSO_011525 ENOG4108ZAA Alkaline-shock protein KSO_011530 ENOG4105VB9 50S ribosomal protein l28 KSO_011540 ENOG4105FJ0 thiamine KSO_011545 ENOG4105DJV ribulose-phosphate 3-epimerase KSO_011550 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KSO_011555 ENOG4105D9P serine threonine protein kinase KSO_011560 ENOG4108ZF3 Phosphatase KSO_011565 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KSO_011570 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KSO_011575 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KSO_011580 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KSO_011585 ENOG4105C25 Primosomal protein n' KSO_011590 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KSO_011600 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KSO_011605 ENOG4105KC4 UPF0296 protein KSO_011610 ENOG4105DSJ YicC domain protein KSO_011620 ENOG4105F23 Fibronectin-binding protein KSO_011625 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KSO_011630 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KSO_011635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KSO_011645 ENOG4107RIQ Sulfate adenylate transferase KSO_011665 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KSO_011670 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) KSO_011675 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) KSO_011680 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) KSO_011685 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KSO_011690 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KSO_011700 ENOG4105CXT aspartate transcarbamylase KSO_011710 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) KSO_011715 ENOG4105C34 Pseudouridine synthase KSO_011720 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) KSO_011730 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KSO_011745 ENOG4105DBK s4 domain protein KSO_011750 ENOG41067XK integral membrane protein KSO_011755 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) KSO_011760 ENOG4105DFA alanine racemase domain protein KSO_011765 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KSO_011770 ENOG4105WR5 sporulation protein, YlmC YmxH family KSO_011780 ENOG4105DKW ABC transporter KSO_011790 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KSO_011795 ENOG4105FFI sigma-e processing peptidase spoiiga KSO_011805 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KSO_011810 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KSO_011815 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KSO_011820 ENOG4105D4A Cell wall formation (By similarity) KSO_011825 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KSO_011830 ENOG4105CNI cell division protein FtsW KSO_011835 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KSO_011840 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KSO_011845 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KSO_011850 ENOG4105CJN penicillin-binding protein KSO_011855 ENOG4105CJN penicillin-binding protein KSO_011865 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KSO_011870 ENOG4108V6E Cell division protein mraZ KSO_011895 ENOG41067VY 50S ribosomal protein L32 KSO_011900 ENOG4105KNH Nucleic acid-binding protein KSO_011910 ENOG4105CDE UPF0348 protein KSO_011915 ENOG41063PX domain protein KSO_011920 ENOG4105D78 K07001 NTE family protein KSO_011925 ENOG4105H20 Sporulation integral membrane protein YlbJ KSO_011930 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KSO_011935 ENOG4106H78 methyltransferase KSO_011965 ENOG4106UY4 Inherit from COG: Scp-like extracellular KSO_011970 ENOG41080XQ Signal transduction protein with cbs domains KSO_011985 ENOG41064X9 cytochrome C oxidase subunit IV KSO_011990 ENOG4105CCU oxidase (Subunit III) KSO_011995 ENOG4105BZ9 Cytochrome C oxidase, subunit I KSO_012005 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KSO_012015 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KSO_012020 ENOG4105CNI cell division protein FtsW KSO_012030 ENOG4105CSV Glutaminase KSO_012040 ENOG4108IAB Phoh family KSO_012055 ENOG4105QA2 KSO_012060 ENOG4105CI3 gtp-binding protein typa KSO_012080 ENOG4105D4Y metalloprotease KSO_012090 ENOG4105ECY inositol monophosphatase KSO_012105 ENOG4105WBI UPF0223 protein KSO_012115 ENOG4105CXN decarboxylase KSO_012135 ENOG4107QN2 dihydrolipoyl dehydrogenase KSO_012140 ENOG4105C7S Dehydrogenase KSO_012145 ENOG4105CPP Dehydrogenase, E1 component KSO_012155 ENOG4105FQP Beta-lactamase KSO_012160 ENOG4105C0W non-ribosomal peptide synthetase KSO_012165 ENOG4107SQU synthase KSO_012170 ENOG4107SQU synthase KSO_012175 ENOG4107SQU synthase KSO_012180 ENOG4105C0W non-ribosomal peptide synthetase KSO_012185 ENOG4107SQU synthase KSO_012190 ENOG4105C0W non-ribosomal peptide synthetase KSO_012195 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KSO_012210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KSO_012215 ENOG4108X4Q Hydrolase KSO_012220 ENOG4106148 UPF0356 protein KSO_012225 ENOG4105CN5 Metallo-Beta-Lactamase KSO_012230 ENOG4105CPN adenine deaminase KSO_012235 ENOG4107ZYR domain protein KSO_012245 ENOG4105BZU Histidine kinase KSO_012270 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KSO_012275 ENOG4105C5H ABC transporter KSO_012290 ENOG4105DM4 PTS System KSO_012295 ENOG4105DE4 1-phosphofructokinase KSO_012300 ENOG4105E98 transcriptional regulator DeoR family KSO_012305 ENOG4107RBB ABC transporter, permease KSO_012310 ENOG4105C19 ABC transporter KSO_012315 ENOG4107X8C Efflux transporter RND family MFP subunit KSO_012325 ENOG41067WU Molybdopterin converting factor (Subunit 1) KSO_012330 ENOG4108ZAF Molybdopterin KSO_012335 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KSO_012340 ENOG4105CVM Molybdenum cofactor synthesis domain protein KSO_012345 ENOG4105D06 uba thif-type nad fad binding protein KSO_012350 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KSO_012365 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KSO_012370 ENOG4105D8X mechanosensitive ion channel KSO_012390 ENOG4105NQC Flavodoxin KSO_012420 ENOG4108XRC Protein of unknown function (DUF458) KSO_012425 ENOG4107IN1 Protein of unknown function (DUF1797) KSO_012430 ENOG4105EPM Diguanylate phosphodiesterase KSO_012445 ENOG4105K6S Short-chain dehydrogenase reductase Sdr KSO_012455 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein KSO_012465 ENOG4105UIN KSO_012470 ENOG4107R88 Chemotaxis protein (CheV) KSO_012480 ENOG4105CHM Aminotransferase KSO_012485 ENOG4105BZU Histidine kinase KSO_012495 ENOG4105K4I Scp-like extracellular KSO_012510 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KSO_012515 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KSO_012520 ENOG4105F6S Spore photoproduct lyase KSO_012530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KSO_012535 ENOG4105KRI phosphocarrier protein (HPr KSO_012545 ENOG4105CID antiterminator KSO_012560 ENOG4105DC7 peptidase M24 KSO_012565 ENOG4105C59 p-type ATPase KSO_012580 ENOG4105F0V Cell wall hydrolase KSO_012600 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KSO_012605 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KSO_012610 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase KSO_012615 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KSO_012625 ENOG4108K88 Membrane KSO_012640 ENOG4105E14 MotA TolQ exbB proton channel KSO_012645 ENOG4105ER2 Ompa motb domain protein KSO_012650 ENOG41090MY MarR family Transcriptional regulator KSO_012655 ENOG4105BZU Histidine kinase KSO_012665 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KSO_012670 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) KSO_012675 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) KSO_012680 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KSO_012690 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KSO_012700 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KSO_012710 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KSO_012715 ENOG4105BZU Histidine kinase KSO_012720 ENOG4108TGC Acyltransferase KSO_012740 ENOG4105D0M Protease HtpX homolog KSO_012750 ENOG410681C small acid-soluble spore protein KSO_012760 ENOG4108WZW RNA polymerase sigma KSO_012765 ENOG4107TS3 membrane protein, TerC KSO_012770 ENOG4107T5V SNARE associated Golgi KSO_012780 ENOG4105FDF Could be involved in DNA repair (By similarity) KSO_012785 ENOG4105DQE DNA ligase KSO_012810 ENOG4105V75 Transcriptional regulator KSO_012815 ENOG4105CJW magnesium transporter KSO_012830 ENOG4105VRS hydrolase family 18 KSO_012835 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein KSO_012840 ENOG4108JJB ABC transporter KSO_012845 ENOG4108W7F transporter, permease KSO_012860 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KSO_012865 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) KSO_012870 ENOG4108Y4K DNA-binding transcriptional activator KSO_012875 ENOG4105D8G Major Facilitator superfamily KSO_012885 ENOG4107TVC Glycosyl transferase, family 2 KSO_012900 ENOG4108ZHJ Organic hydroperoxide resistance protein KSO_012905 ENOG4105K56 Transcriptional regulator KSO_012920 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KSO_012925 ENOG4105CIY formyltetrahydrofolate deformylase KSO_012930 ENOG41080TC multidrug resistance protein KSO_012940 ENOG4108428 Inherit from COG: -acetyltransferase KSO_012945 ENOG4108S4H thioesterase Superfamily protein KSO_012950 ENOG4107TUM Amidinotransferase KSO_012955 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KSO_012960 ENOG4108JQ7 (ABC) transporter KSO_012965 ENOG4107SN7 NLP P60 protein KSO_012970 ENOG4105DTQ mandelate racemase muconate lactonizing KSO_012975 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KSO_012985 ENOG4105C3U ABC transporter KSO_012990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KSO_012995 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KSO_013000 ENOG4108ME1 Peptidase M55 D-aminopeptidase KSO_013010 ENOG4105C0H protease KSO_013020 ENOG4105CKK Glycosyl transferase, family 2 KSO_013025 ENOG4105EDW glycosyl transferase, family 39 KSO_013035 ENOG4107R7I amino acid KSO_013045 ENOG4107GRR phosphate transport regulator KSO_013050 ENOG4105CJ3 phosphate transporter KSO_013070 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KSO_013100 ENOG41068G1 KSO_013110 ENOG410906S phage-like element pbsx protein xkdt KSO_013115 ENOG41066EA baseplate J family protein KSO_013120 ENOG4105MFU Protein of unknown function (DUF2634) KSO_013130 ENOG4105X7F KSO_013135 ENOG4108WZM domain protein KSO_013140 ENOG4108FKH Transglycosylase SLT domain KSO_013140 ENOG4108FKH Transglycosylase SLT domain KSO_013140 ENOG4108FKH Transglycosylase SLT domain KSO_013150 ENOG4105MTC XkdN-like protein KSO_013155 ENOG4105FR7 XkdM protein, phage-like element PBSX KSO_013160 ENOG4105PQS phage protein KSO_013175 ENOG41060SN KSO_013200 ENOG4108MDF Phage Portal Protein KSO_013205 ENOG4105IG6 Phage terminase, large subunit KSO_013210 ENOG4108TFU terminase (Small subunit) KSO_013255 ENOG410635T phage-like element pbsx protein KSO_013265 ENOG4105K7W phage-related replication protein KSO_013270 ENOG4105KWG Pfam:DUF1696 KSO_013275 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KSO_013295 ENOG4107TSN permease KSO_013305 ENOG4108JJA ABC, transporter KSO_013320 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_013325 ENOG4105BZU Histidine kinase KSO_013350 ENOG4105F3H Histidine kinase KSO_013355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KSO_013360 ENOG4105CTX dehydratase KSO_013365 ENOG4107QZW Altronate oxidoreductase KSO_013370 ENOG4107KJX Transcriptional regulator KSO_013375 ENOG4105CT4 transporter KSO_013380 ENOG4105D2H Uronic isomerase KSO_013395 ENOG4105Q95 Cupin 2, conserved barrel domain protein KSO_013405 ENOG4108IXI (ABC) transporter KSO_013410 ENOG4105C4B ABC transporter, permease KSO_013415 ENOG4105EXQ uroporphyrinogen iii synthase hem4 KSO_013425 ENOG41087PP glycosyltransferase MGT family KSO_013430 ENOG4106A3M Cytochrome p-450 KSO_013440 ENOG4108IEG Formate dehydrogenase Alpha subunit KSO_013460 ENOG4105KT7 mgtC SapB transporter KSO_013465 ENOG4105K56 Transcriptional regulator KSO_013480 ENOG4105E98 transcriptional regulator DeoR family KSO_013490 ENOG4105VCP PTS System KSO_013495 ENOG4105CK1 PTS System KSO_013500 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KSO_013505 ENOG4105CMR udp-glucose 4-epimerase KSO_013510 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase KSO_013540 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase KSO_013550 ENOG4106BHF KSO_013585 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KSO_013765 ENOG4105QBX endodeoxyribonuclease RusA KSO_013845 ENOG41067QW Transcriptional regulator KSO_013855 ENOG410635T phage-like element pbsx protein KSO_013860 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) KSO_013865 ENOG4105C28 cystathionine KSO_013870 ENOG4105C28 cystathionine KSO_013885 ENOG4108ZMI UPF0477 protein KSO_013900 ENOG4105CJ1 ABC, transporter KSO_013920 ENOG4105ENA helicase KSO_013970 ENOG4107A88 KSO_013975 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KSO_013980 ENOG4105DWF phosphomethylpyrimidine kinase KSO_013985 ENOG4105D06 uba thif-type nad fad binding protein KSO_014005 ENOG4108VEU Thiamine monophosphate synthase KSO_014010 ENOG4105ETU transcriptional activator (TenA KSO_014020 ENOG4107S1Q Phosphatase KSO_014025 ENOG4105EMS pseudouridine synthase KSO_014030 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KSO_014045 ENOG4105MIX Adenylate cyclase KSO_014050 ENOG4105E4C Lytic transglycosylase catalytic KSO_014055 ENOG4108Z18 K06886 hemoglobin KSO_014060 ENOG4105T58 Dithiol-disulfide isomerase KSO_014070 ENOG4105DPN Oligoendopeptidase f KSO_014080 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis KSO_014085 ENOG4108ZCF integral membrane protein KSO_014090 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) KSO_014105 ENOG4108JQ7 (ABC) transporter KSO_014115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KSO_014120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KSO_014125 ENOG4108J59 Extracellular solute-binding protein, family 5 KSO_014130 ENOG4105C31 Tryptophanyl-tRNA synthetase KSO_014140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KSO_014155 ENOG4108JQ7 (ABC) transporter KSO_014160 ENOG4105C3U ABC transporter KSO_014170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KSO_014175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KSO_014190 ENOG4107RMD Basic membrane lipoprotein KSO_014220 ENOG4105DBV ornithine carbamoyltransferase KSO_014230 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KSO_014235 ENOG4105C8Y Acetylornithine aminotransferase KSO_014240 ENOG4105CAS nag kinase KSO_014250 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KSO_014260 ENOG4105IQ5 FAD linked oxidase domain protein KSO_014265 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KSO_014270 ENOG4105VG1 fes assembly suf system protein KSO_014275 ENOG4108MXZ Esterase KSO_014280 ENOG4108KP7 hydrolase KSO_014290 ENOG41073B9 KSO_014305 ENOG4107AYK membrAne KSO_014310 ENOG4105EPR degv family KSO_014320 ENOG4105C8Q Methyl-accepting chemotaxis KSO_014325 ENOG4105DIH basic membrane KSO_014330 ENOG4105QNR S1 RNA binding domain protein KSO_014335 ENOG4108VPT UPF0234 protein KSO_014345 ENOG4105MA6 gCN5-related N-acetyltransferase KSO_014350 ENOG4105MYW Pentapeptide repeat protein KSO_014355 ENOG4105SF0 DinB family KSO_014360 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KSO_014365 ENOG4105ETE Transcriptional regulator (LacI family KSO_014370 ENOG4106HBX Transcriptional Regulator AraC Family KSO_014375 ENOG4105UQX Mate efflux family protein KSO_014385 ENOG4105CAQ asparagine synthetase KSO_014405 ENOG4105ERH Fumarylacetoacetate hydrolase KSO_014450 ENOG4105EYH Exonuclease KSO_014460 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KSO_014465 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination KSO_014470 ENOG4108QY0 Membrane KSO_014480 ENOG4108IG5 Transcriptional regulator KSO_014490 ENOG4108KK1 membrane protein AbrB duplication KSO_014495 ENOG4108INS Transcriptional regulator KSO_014500 ENOG4107SCK Monooxygenase KSO_014515 ENOG41060YP KSO_014520 ENOG4106CAD Protein of unknown function (DUF3311) KSO_014525 ENOG4105E1V na solute symporter KSO_014530 ENOG4105K8R UPF0145 protein KSO_014535 ENOG4105X3H Excalibur domain protein KSO_014545 ENOG4108ZMX Domain of unknown function (DU1801) KSO_014555 ENOG4105XVF Competence transcription factor KSO_014575 ENOG4106YBV Methyl-accepting chemotaxis KSO_014580 ENOG4107ZYJ bioY protein KSO_014585 ENOG4107F3J Amp-dependent synthetase and ligase KSO_014595 ENOG4107TB6 phosphoglycerate mutase KSO_014600 ENOG4108HUF Transporter KSO_014615 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KSO_014625 ENOG4105CEY Amp-dependent synthetase and ligase KSO_014635 ENOG4105DF9 Lipoate-protein, ligase KSO_014640 ENOG4108RQ5 Beta-lactamase domain-containing protein KSO_014645 ENOG4106AXD KSO_014655 ENOG4105DER m42 family KSO_014670 ENOG4105ECB domain protein KSO_014680 ENOG4105C1Q protoporphyrinogen oxidase KSO_014685 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KSO_014690 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KSO_014695 ENOG4105BZ4 penicillin-binding protein KSO_014700 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KSO_014730 ENOG4105K59 histidine triad (HIT) protein KSO_014735 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) KSO_014740 ENOG4105NBU tryptophan transport protein KSO_014780 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KSO_014790 ENOG4105EQI Metal Dependent Phosphohydrolase KSO_014795 ENOG4106D4I domain protein KSO_014800 ENOG4107VRP DNA repair exonuclease KSO_014805 ENOG4105RHA ABC transporter, permease KSO_014810 ENOG4108IUX (ABC) transporter KSO_014820 ENOG4105CGU Enoyl-CoA hydratase KSO_014830 ENOG4105NCW Trka-c domain protein KSO_014835 ENOG4107S91 Sodium hydrogen exchanger KSO_014845 ENOG4105D4P Coproporphyrinogen iii oxidase KSO_014855 ENOG4105F1N DNA alkylation repair KSO_014860 ENOG4105WZB UPF0342 protein KSO_014865 ENOG4106MP8 UPF0754 membrane protein KSO_014875 ENOG410839P KSO_014900 ENOG4105BZ1 (ABC) transporter KSO_014905 ENOG4105BZ1 (ABC) transporter KSO_014915 ENOG4105IIP Membrane KSO_014920 ENOG4105W1N transcriptional regulator KSO_014925 ENOG4105F0I Aminotransferase KSO_014930 ENOG4107VMI polysaccharide deacetylase KSO_014935 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KSO_014940 ENOG4105D64 Mechanosensitive ion channel KSO_014950 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KSO_014955 ENOG4105WMR Protein CrcB homolog KSO_014965 ENOG4105C37 (CBS) domain KSO_014970 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase KSO_014975 ENOG4105CHM Aminotransferase KSO_014985 ENOG4105C37 (CBS) domain KSO_014990 ENOG4105F6E Acyl-transferase KSO_014995 ENOG4108AEY RNA polymerase sigma factor KSO_015000 ENOG4105J37 KSO_015010 ENOG4105C8J )-transporter KSO_015015 ENOG4105CUB amino acid KSO_015020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KSO_015025 ENOG4105BZN citrate synthase KSO_015040 ENOG4105G6Z alkaline phosphatase KSO_015045 ENOG4105ED1 spovr family KSO_015080 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_015085 ENOG4105BZU Histidine kinase KSO_015095 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KSO_015100 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KSO_015110 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KSO_015115 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KSO_015120 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KSO_015125 ENOG4107YBY Hydrolase KSO_015130 ENOG41080XP Cbs domain KSO_015140 ENOG4108YBP pseudouridine synthase KSO_015180 ENOG4105BZU Histidine kinase KSO_015190 ENOG4105VEQ Cold shock protein KSO_015195 ENOG4108TU7 Inherit from COG: (ABC) transporter KSO_015200 ENOG4105CJ1 ABC, transporter KSO_015205 ENOG4105CZV ABC transporter KSO_015210 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KSO_015225 ENOG4105CS1 NAD(P)H quinone oxidoreductase KSO_015230 ENOG4105C0R drug resistance transporter emrb qaca subfamily KSO_015235 ENOG4105CW7 secretion protein, HlyD family KSO_015240 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes KSO_015250 ENOG4105CYN Serine protein kinase KSO_015275 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KSO_015285 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KSO_015295 ENOG4105VZ8 Transcriptional regulator KSO_015300 ENOG4107D63 KSO_015305 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KSO_015315 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KSO_015320 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KSO_015325 ENOG4105E2Y ABC, transporter KSO_015345 ENOG4108JQ7 (ABC) transporter KSO_015350 ENOG4105C3U ABC transporter KSO_015355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KSO_015365 ENOG4105DEF Extracellular solute-binding protein, family 5 KSO_015375 ENOG4105DNP FAD linked oxidase domain protein KSO_015380 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KSO_015385 ENOG4105EC3 peptidase S51, dipeptidase E KSO_015400 ENOG4105TUA UPF0295 protein KSO_015405 ENOG4105G5W regulator Fur family KSO_015410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KSO_015415 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KSO_015420 ENOG4107NBY Membrane KSO_015425 ENOG4105BZ1 (ABC) transporter KSO_015445 ENOG4105CAN Short-chain dehydrogenase reductase Sdr KSO_015450 ENOG4106BXE KSO_015455 ENOG4105CEN a g-specific adenine glycosylase KSO_015460 ENOG41067AE Membrane-bound metal-dependent hydrolase KSO_015465 ENOG4105EJV Membrane KSO_015470 ENOG4105CKK Glycosyl transferase, family 2 KSO_015475 ENOG4105D74 hydrolase KSO_015480 ENOG4106AKJ KSO_015500 ENOG4108TCS Glutamyl endopeptidase KSO_015510 ENOG4105F27 Major Facilitator KSO_015520 ENOG410902V Modulates RecA activity (By similarity) KSO_015525 ENOG4105ECP epimerase KSO_015540 ENOG4107Y03 Nitroreductase KSO_015545 ENOG4105JAB phenazine biosynthesis protein, phzf family KSO_015555 ENOG410834F Transcriptional regulator KSO_015560 ENOG4105C0R drug resistance transporter emrb qaca subfamily KSO_015565 ENOG4108YYS metal-dependent hydrolase (By similarity) KSO_015580 ENOG4105H93 Acyltransferase family KSO_015585 ENOG4105DYS nad(p)h dehydrogenase (quinone) KSO_015590 ENOG4105U3E Transcriptional regulator KSO_015595 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KSO_015600 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KSO_015610 ENOG4105BZ1 (ABC) transporter KSO_015615 ENOG4105BZ1 (ABC) transporter KSO_015620 ENOG4105CI1 PTS System KSO_015625 ENOG4108Q3X Transcriptional regulator KSO_015630 ENOG4105F8D glycoside hydrolase family 4 KSO_015640 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KSO_015650 ENOG4107QKR Dehydrogenase KSO_015660 ENOG4107RUY (E1 component), alpha subunit KSO_015680 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KSO_015690 ENOG4105D7N magnesium and cobalt transport protein CorA KSO_015700 ENOG4106KE4 Dehydrogenase KSO_015720 ENOG4105D8X mechanosensitive ion channel KSO_015730 ENOG4105UPD Calcium Proton KSO_015735 ENOG4108ISG Major Facilitator KSO_015745 ENOG4107U9T Pfam:Ribonuclease_BN KSO_015755 ENOG4105KJF protein tyrosine phosphatase KSO_015770 ENOG4105FF2 Type I DHQase KSO_015775 ENOG4105E2X shikimate dehydrogenase KSO_015780 ENOG4105ETE Transcriptional regulator (LacI family KSO_015785 ENOG4107RKG DJ-1/PfpI family KSO_015790 ENOG4105CGH 5'-nucleotidase KSO_015805 ENOG4108RCM Nitroreductase KSO_015810 ENOG4107414 GntR family transcriptional regulator KSO_015815 ENOG4105CG3 alpha amylase, catalytic region KSO_015820 ENOG4105C5Y PTS System KSO_015860 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KSO_015880 ENOG4108RPX mosc domain containing protein KSO_015885 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) KSO_015910 ENOG4108MRH transcriptional regulatory protein KSO_015920 ENOG4108Z6X (sortase) family KSO_015930 ENOG4108VAC response regulator KSO_015955 ENOG4107QPK )-transporter KSO_015960 ENOG4108J20 pectate lyase KSO_015975 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KSO_015990 ENOG4105FDU atp-dependent rna helicase KSO_015995 ENOG4105C5H ABC transporter KSO_016000 ENOG4105DXB Major Facilitator superfamily KSO_016005 ENOG4107SWG transcriptional regulator MERR family KSO_016010 ENOG4105C5H ABC transporter KSO_016015 ENOG4107TVC Glycosyl transferase, family 2 KSO_016020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KSO_016025 ENOG4105FKZ Methyl-accepting chemotaxis KSO_016030 ENOG4105C26 Dehydrogenase KSO_016035 ENOG4105CUB amino acid KSO_016040 ENOG4105EU0 Major facilitator Superfamily KSO_016045 ENOG41090R9 glycosyltransferase KSO_016050 ENOG4107R51 Glycosyl transferase, family 2 KSO_016055 ENOG41090R9 glycosyltransferase KSO_016065 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase KSO_016070 ENOG4105E0M Sulfatase KSO_016080 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KSO_016085 ENOG4108R1P KSO_016090 ENOG41061H0 Monooxygenase KSO_016095 ENOG41082F9 transcriptional regulator KSO_016100 ENOG4106I4J membrane KSO_016120 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KSO_016125 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KSO_016130 ENOG4105H67 Protein of unknown function (DUF421) KSO_016140 ENOG4105M18 -acetyltransferase KSO_016145 ENOG4105WEF catalase KSO_016160 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KSO_016170 ENOG4105CDY transcriptional regulatory protein KSO_016195 ENOG4105CJ1 ABC, transporter KSO_016205 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KSO_016210 ENOG4105CBD Diacylglycerol kinase KSO_016220 ENOG4108IG5 Transcriptional regulator KSO_016225 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KSO_016230 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KSO_016235 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KSO_016240 ENOG4105CK7 Sodium proline symporter KSO_016245 ENOG4105KT7 mgtC SapB transporter KSO_016250 ENOG4105CRN Aminoglycoside phosphotransferase KSO_016260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KSO_016265 ENOG4105C4R Atp-dependent dna helicase KSO_016280 ENOG4105CBC glutamate synthase KSO_016285 ENOG4105KGF protein, YerC YecD KSO_016290 ENOG4108R5T secreted protein KSO_016305 ENOG4105C12 Phosphoribosylglycinamide synthetase KSO_016310 ENOG4105DC1 bifunctional purine biosynthesis protein purh KSO_016315 ENOG4108V3E phosphoribosylglycinamide formyltransferase KSO_016320 ENOG4105CXB phosphoribosylaminoimidazole synthetase KSO_016330 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii KSO_016335 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KSO_016340 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KSO_016345 ENOG4105C8V SAICAR synthetase KSO_016350 ENOG4105C83 adenylosuccinate lyase KSO_016355 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KSO_016360 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KSO_016380 ENOG4105C7N Xanthine uracil vitamin C permease KSO_016395 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KSO_016410 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KSO_016415 ENOG4105C85 amino acid KSO_016420 ENOG4107STQ Multicopper oxidase KSO_016450 ENOG4105JVQ RNA Polymerase KSO_016455 ENOG4108P49 AntiSigma factor KSO_016460 ENOG4105EXC Acyl-transferase KSO_016470 ENOG4108WV1 Pfam:DUF477 KSO_016475 ENOG4105DQX Zinc finger domain KSO_016480 ENOG41087YS Phage shock protein A KSO_016495 ENOG4105CT4 transporter KSO_016500 ENOG4105CPQ Dehydrogenase KSO_016505 ENOG4105PGZ NB-ARC domain KSO_016525 ENOG4105ESF Peptidoglycan binding domain protein KSO_016530 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KSO_016535 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KSO_016540 ENOG4108TYN CAAX amino terminal protease family protein KSO_016550 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KSO_016555 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KSO_016560 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) KSO_016565 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KSO_016570 ENOG4105C5H ABC transporter KSO_016575 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KSO_016580 ENOG410801F ribosomal-protein-alanine acetyltransferase KSO_016585 ENOG41072GX Peptidase M22 Glycoprotease KSO_016590 ENOG4105K8N protein family UPF0079, ATPase KSO_016595 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) KSO_016600 ENOG4107QNK )-transporter KSO_016620 ENOG4107QTZ amino acid KSO_016640 ENOG4105DJ2 Major Facilitator Superfamily KSO_016645 ENOG4105JXH GntR family transcriptional regulator KSO_016650 ENOG4108TZY GntR Family Transcriptional Regulator KSO_016655 ENOG4108SUT Major Facilitator Superfamily KSO_016660 ENOG41090UD (LipO)protein KSO_016695 ENOG4105DRR Transcriptional regulator, GntR family KSO_016700 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KSO_016705 ENOG4105EBM Alpha Beta Hydrolase Fold protein KSO_016720 ENOG41090E6 transcriptional regulator MERR family KSO_016740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KSO_016745 ENOG4105C2C drug resistance transporter, Bcr CflA KSO_016755 ENOG4108JYZ YitT family KSO_016775 ENOG4105EYF MMPL domain protein KSO_016780 ENOG4108VB1 regulatoR KSO_016785 ENOG4105ENE Histidine kinase KSO_016800 ENOG4105PGS Spore coat protein KSO_016805 ENOG4105E2A Dehydrogenase KSO_016820 ENOG4108JGH Tetr family transcriptional regulator KSO_016825 ENOG4105EQ0 Major Facilitator superfamily KSO_016840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KSO_016850 ENOG4105VUF Transcriptional regulator KSO_016855 ENOG4105DQ4 alcohol dehydrogenase KSO_016880 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KSO_016890 ENOG4108U7W acetyltransferase KSO_016900 ENOG4105H3G oxidoreductase KSO_016905 ENOG4105PGM cation diffusion facilitator family transporter KSO_016920 ENOG4105DNP FAD linked oxidase domain protein KSO_016935 ENOG41062IR nudix hydrolase KSO_016940 ENOG4105DXI Major Facilitator superfamily KSO_016945 ENOG4107U9B transcriptional regulator KSO_016950 ENOG4105CE7 Amidase, hydantoinase carbamoylase family KSO_016955 ENOG4108MCI Transcriptional regulator, ARAC family KSO_016960 ENOG4105CH2 amidohydrolase KSO_016965 ENOG4105C44 Serine transporter KSO_016970 ENOG4105KME endoribonuclease L-psp KSO_016975 ENOG4108WYP Transcriptional regulator KSO_016980 ENOG4107RCH Diaminopropionate ammonia-lyase KSO_016990 ENOG4105IRW patatin-like phospholipase family protein KSO_017010 ENOG41087NI Sulfite exporter TauE/SafE KSO_017015 ENOG4105VFE sira family KSO_017020 ENOG4107TPS domain protein KSO_017025 ENOG4105VFE sira family KSO_017030 ENOG4105C72 UPF0176 protein KSO_017035 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase KSO_017040 ENOG4105XTG Pfam:DUF156 KSO_017045 ENOG4105VEQ Cold shock protein KSO_017050 ENOG4108RYK Nad-dependent epimerase dehydratase KSO_017055 ENOG4108Z40 Transcriptional regulator KSO_017065 ENOG4108ZMQ domain protein KSO_017075 ENOG4105K56 Transcriptional regulator KSO_017090 ENOG4105CSH Transporter KSO_017105 ENOG4106BHF KSO_017110 ENOG4106ANW SMI1_KNR4 KSO_017140 ENOG4106BHR ftsk SpoIIIE family protein KSO_017145 ENOG410906U SprT-like KSO_017160 ENOG41064BQ Phosphatase KSO_017170 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KSO_017175 ENOG4105WN5 stage II sporulation protein KSO_017180 ENOG4107SGM protein serine threonine phosphatase KSO_017185 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase KSO_017190 ENOG4105FUA antagonist KSO_017195 ENOG4107MMM Anti-sigma-factor antagonist KSO_017200 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KSO_017210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KSO_017215 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein KSO_017220 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KSO_017230 ENOG4105CKV Membrane KSO_017235 ENOG410905X membrane-flanked domain protein KSO_017240 ENOG4105C1J atp-dependent rna helicase KSO_017250 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KSO_017255 ENOG4105CPF Cell wall formation (By similarity) KSO_017260 ENOG4105SZ6 Thioredoxin KSO_017280 ENOG4105FDT acyl-CoA dehydrogenase KSO_017295 ENOG4105CJ1 ABC, transporter KSO_017300 ENOG4106F5Q Membrane KSO_017305 ENOG4107QJT sodium dicarboxylate symporter KSO_017310 ENOG4108MRH transcriptional regulatory protein KSO_017315 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KSO_017320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KSO_017335 ENOG41082W1 Cupin 2, conserved barrel domain protein KSO_017340 ENOG4105QVS general stress protein KSO_017345 ENOG4105EU9 KSO_017350 ENOG4105KPY Small multidrug resistance protein KSO_017355 ENOG4105RXJ KSO_017360 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) KSO_017370 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KSO_017410 ENOG4105C0X amino acid KSO_017420 ENOG4107R8N Glycosyl transferase, family 2 KSO_017425 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KSO_017440 ENOG4105C9U ATP-dependent DNA helicase RecQ KSO_017450 ENOG4105VCH membrane KSO_017460 ENOG410606W general stress protein KSO_017475 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KSO_017485 ENOG4105ETD TRANSCRIPTIONal KSO_017490 ENOG4107QM2 Aldo Keto reductase KSO_017495 ENOG4107RVG penicillin-binding protein KSO_017500 ENOG41061CK Antibiotic biosynthesis monooxygenase KSO_017510 ENOG4105XJB lipolytic protein G-D-S-L family KSO_017515 ENOG4107258 Transcriptional regulator KSO_017525 ENOG4105P4J Allophanate hydrolase, subunit 1 KSO_017530 ENOG4105CFM UPF0317 protein KSO_017535 ENOG4105C5A transporter KSO_017540 ENOG4105E7W lamb ycsf family protein KSO_017560 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase KSO_017580 ENOG4108ZYE Transcriptional regulator KSO_017585 ENOG4108T5E Copper resistance protein KSO_017590 ENOG4105KTB nuclear export factor GLE1 KSO_017595 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KSO_017610 ENOG4105C26 Dehydrogenase KSO_017615 ENOG4108JPW Aminotransferase KSO_017625 ENOG4105YVS arsR family transcriptional regulator KSO_017630 ENOG41067V3 Antibiotic biosynthesis monooxygenase KSO_017635 ENOG4108DBC nitroreductase KSO_017640 ENOG4105R8C Transcriptional regulator KSO_017655 ENOG4108IPW abc transporter atp-binding protein KSO_017660 ENOG4105CM4 permease protein KSO_017665 ENOG4105DHS permease protein KSO_017670 ENOG4105CFH Aspartokinase KSO_017690 ENOG4105BZU Histidine kinase KSO_017695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KSO_017700 ENOG4107WD8 ABC transporter, permease KSO_017710 ENOG4108PGP mmge prpd family protein KSO_017715 ENOG4105CH2 amidohydrolase KSO_017725 ENOG4108HW4 amino acid AbC transporter KSO_017730 ENOG4105EAB amino acid AbC transporter KSO_017735 ENOG4108XSB acetyltransferase, (GNAT) family KSO_017740 ENOG4105CPU Monooxygenase KSO_017755 ENOG4105E1K spore germination protein KSO_017770 ENOG4105DUX Transporter KSO_017775 ENOG41069ZX KSO_017780 ENOG41069ZX KSO_017785 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KSO_017790 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase KSO_017795 ENOG4106P55 Transcriptional regulator KSO_017805 ENOG4105DRP amino acid AbC transporter KSO_017810 ENOG4105CDA abc transporter atp-binding protein KSO_017825 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KSO_017845 ENOG4105CEY Amp-dependent synthetase and ligase KSO_017850 ENOG4105KVH Transcriptional regulator KSO_017855 ENOG4108VA3 3-hexulose-6-phosphate synthase KSO_017860 ENOG41080HJ 6-phospho 3-hexuloisomerase KSO_017875 ENOG4105CS2 ec 3.2.1.21 KSO_017880 ENOG4105CS2 ec 3.2.1.21 KSO_017890 ENOG4105HHM rdd domain containing protein KSO_017895 ENOG4105E2A Dehydrogenase KSO_017900 ENOG4105CKI cobalamin synthesis protein KSO_017905 ENOG4108IFG nitrite reductase, (NAD(P)H) KSO_017910 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KSO_017915 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KSO_017920 ENOG4105CAY ferredoxin--nadp reductase KSO_017925 ENOG4107YHD transcriptional regulator KSO_017930 ENOG4105CK7 Sodium proline symporter KSO_017935 ENOG4105C26 Dehydrogenase KSO_017945 ENOG410756H nucleotidyltransferase KSO_017950 ENOG4105I82 acetyl xylan esterase KSO_017955 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KSO_017960 ENOG4105DJB Major Facilitator Superfamily KSO_017970 ENOG4105I1F Resistance protein KSO_017980 ENOG4107RA1 nh(3)-dependent nad( ) synthetase KSO_017985 ENOG4105EIG urea carboxylase-associated protein 1 KSO_018015 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KSO_018045 ENOG4107SQ8 Glycine betaine KSO_018050 ENOG4108IJ7 Glycine betaine KSO_018055 ENOG41079KZ Major Facilitator Superfamily KSO_018065 ENOG4108TTB tellurium resistance protein KSO_018070 ENOG4107TS3 membrane protein, TerC KSO_018075 ENOG4106FN3 tellurium resistance protein KSO_018080 ENOG4106FN3 tellurium resistance protein KSO_018085 ENOG4108N0M stress protein KSO_018090 ENOG4105DEN Luciferase family KSO_018100 ENOG4105DIK (ABC) transporter KSO_018105 ENOG4105DSE periplasmic solute binding protein KSO_018115 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KSO_018145 ENOG4107SET aldo keto reductase KSO_018150 ENOG41060AI SEC-C motif KSO_018155 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KSO_018170 ENOG4105J7D transcriptional regulator KSO_018175 ENOG4105C0R drug resistance transporter emrb qaca subfamily KSO_018180 ENOG4107EPV Aminotransferase class V KSO_018185 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) KSO_018190 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KSO_018195 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KSO_018200 ENOG4105DGI Alkaline phosphatase KSO_018215 ENOG4105XXY Thioredoxin KSO_018220 ENOG4108VGI doxx family KSO_018225 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KSO_018230 ENOG4108TVJ Nitroreductase KSO_018235 ENOG41076HS cation diffusion facilitator family transporter KSO_018260 ENOG4105CSV Glutaminase KSO_018270 ENOG4108J5H Homocysteine s-methyltransferase KSO_018275 ENOG4108IQI permease KSO_018280 ENOG4105CM2 brancheD-chain amino acid aminotransferase KSO_018290 ENOG4105C72 UPF0176 protein KSO_018305 ENOG4107ZTW SNARE associated Golgi KSO_018310 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KSO_018315 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KSO_018320 ENOG4107SCQ Iron-containing alcohol dehydrogenase KSO_018355 ENOG4105CXY transporter KSO_018360 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KSO_018375 ENOG4107QTZ amino acid KSO_018390 ENOG4106DDH Sporulation-specific SASP protein KSO_018415 ENOG4105CJ1 ABC, transporter KSO_018420 ENOG4105WH1 Two component transcriptional regulator luxr family KSO_018425 ENOG4105BZU Histidine kinase KSO_018440 ENOG41061AU MarR family Transcriptional regulator KSO_018450 ENOG41067MG lrgb family KSO_018460 ENOG4106K80 KSO_018490 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KSO_018495 ENOG4107U5W ybbr family KSO_018500 ENOG4105C8B TIGR00159 family KSO_018510 ENOG4105EMN RNA polymerase sigma factor KSO_018520 ENOG4105EWC Purine nucleoside phosphorylase KSO_018530 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate KSO_018545 ENOG4105D17 glycoside hydrolase, family 3 domain protein KSO_018550 ENOG4105EHZ conserved protein UCP016719 KSO_018555 ENOG410874W AraC family transcriptional regulator KSO_018575 ENOG4108SA1 esterase KSO_018585 ENOG4105CHH sulfate transporter KSO_018600 ENOG4108JPW Aminotransferase KSO_018610 ENOG4108NMV polysaccharide deacetylase KSO_018625 ENOG4105D1F ATP-binding protein KSO_018645 ENOG4108I0C methyltransferase KSO_018650 ENOG4108UJD 30S ribosomal protein S9 KSO_018655 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KSO_018660 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KSO_018665 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KSO_018670 ENOG4108JJB ABC transporter KSO_018675 ENOG4108JJB ABC transporter KSO_018680 ENOG4108ZT0 50S ribosomal protein l17 KSO_018685 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KSO_018690 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KSO_018695 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KSO_018705 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) KSO_018710 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KSO_018715 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KSO_018720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KSO_018725 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KSO_018730 ENOG4105VPB 50S ribosomal protein L30 KSO_018735 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) KSO_018740 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KSO_018745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KSO_018750 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KSO_018760 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KSO_018770 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) KSO_018775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KSO_018780 ENOG41082SA 50s ribosomal protein l29 KSO_018785 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KSO_018790 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) KSO_018795 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KSO_018800 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KSO_018805 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity KSO_018810 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KSO_018815 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KSO_018820 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KSO_018825 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KSO_018830 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KSO_018835 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KSO_018840 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KSO_018845 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) KSO_018850 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KSO_018855 ENOG4105XPM ribosomal protein KSO_018860 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KSO_018865 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KSO_018870 ENOG4107Y49 methyltransferase KSO_018875 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KSO_018880 ENOG4108VZM 50s ribosomal protein L10 KSO_018890 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KSO_018895 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KSO_018915 ENOG4105M0M Tetracycline resistance protein KSO_018920 ENOG4105C2N RNA methyltransferase TrmH family group 3 KSO_018925 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) KSO_018935 ENOG4105D7W serine acetyltransferase KSO_018940 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KSO_018945 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KSO_018950 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) KSO_018955 ENOG4105CTP PilT protein domain protein KSO_018960 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) KSO_018965 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KSO_018975 ENOG41066A3 ATP guanido phosphotransferase KSO_018980 ENOG4108Z0C Uvrb UvrC protein KSO_018990 ENOG4105CRK lysyL-tRNA synthetase KSO_018995 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KSO_019005 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KSO_019010 ENOG4105KRF dihydroneopterin aldolase KSO_019015 ENOG4105EEI dihydropteroate synthase KSO_019020 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 KSO_019025 ENOG4105DDQ anthranilate synthase KSO_019030 ENOG4105CRQ synthase (Component I) KSO_019035 ENOG4105C6T cysteine synthase KSO_019040 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase KSO_019045 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KSO_019050 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) KSO_019055 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KSO_019060 ENOG4108UGV hypoxanthine phosphoribosyltransferase KSO_019065 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KSO_019085 ENOG41060GV RNA binding s1 domain protein KSO_019100 ENOG4105VYY sporulation protein yabp KSO_019105 ENOG41082I2 s4 domain protein KSO_019110 ENOG4108IY2 MazG family KSO_019120 ENOG4108M14 stage v sporulation protein t KSO_019125 ENOG4108JA2 transcriptioN-repair coupling factor KSO_019140 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KSO_019145 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KSO_019150 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KSO_019155 ENOG4105K4W Could be involved in septation (By similarity) KSO_019160 ENOG4105KME endoribonuclease L-psp KSO_019165 ENOG4105DFT pur operon repressor KSO_019170 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KSO_019175 ENOG4105XEW small acid-soluble spore protein KSO_019180 ENOG4105W42 Veg protein KSO_019185 ENOG4105XFA sporulation peptidase YabG KSO_019190 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KSO_019200 ENOG41069ER domain protein KSO_019205 ENOG4105F8V Hydrolase, tatD family KSO_019210 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KSO_019215 ENOG4105KRN Transcriptional regulator, abrb family KSO_019220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KSO_019225 ENOG4105VC4 domain protein KSO_019230 ENOG41060K3 Methyltransferase KSO_019240 ENOG4105MA4 psp1 domain protein KSO_019245 ENOG4105FA2 dna polymerase iii KSO_019250 ENOG4105XVJ Protein of unknown function (DUF327) KSO_019255 ENOG4105X0R protein from nitrogen regulatory protein P-II KSO_019260 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KSO_019265 ENOG4105CXN decarboxylase KSO_019270 ENOG4105CDW Resistance protein KSO_019290 ENOG41067KS pro-sigma K processing KSO_019300 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) KSO_019305 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KSO_019310 ENOG4105C6E dna polymerase iii KSO_019315 ENOG4108Z6B deaminase KSO_019320 ENOG4105GTG Isochorismatase KSO_019325 ENOG4105VRS hydrolase family 18 KSO_019335 ENOG4105ZMH deoxynucleoside kinase KSO_019340 ENOG4105BZW Glycerate kinase KSO_019345 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KSO_019350 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) KSO_019355 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) KSO_019365 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KSO_019375 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KSO_019380 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KSO_019390 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) KSO_019395 ENOG410848D S4 domain protein YaaA KSO_019400 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KSO_019405 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)