locus-tag class description KHU1_0002 ENOG4108JPW Aminotransferase KHU1_0004 ENOG4105CPQ Dehydrogenase KHU1_0005 ENOG4105CHH sulfate transporter KHU1_0007 ENOG4108SA1 esterase KHU1_0011 ENOG410874W AraC family transcriptional regulator KHU1_0012 ENOG410874W AraC family transcriptional regulator KHU1_0013 ENOG4105EHZ conserved protein UCP016719 KHU1_0014 ENOG4105D17 glycoside hydrolase, family 3 domain protein KHU1_0017 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate KHU1_0019 ENOG4105EWC Purine nucleoside phosphorylase KHU1_0020 ENOG4105EMN RNA polymerase sigma factor KHU1_0022 ENOG4105C8B TIGR00159 family KHU1_0023 ENOG4107U5W ybbr family KHU1_0024 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) KHU1_0028 ENOG4106K80 KHU1_0030 ENOG41067MG lrgb family KHU1_0032 ENOG41061AU MarR family Transcriptional regulator KHU1_0035 ENOG4105BZU Histidine kinase KHU1_0036 ENOG4105WH1 Two component transcriptional regulator luxr family KHU1_0037 ENOG4105CJ1 ABC, transporter KHU1_0041 ENOG4106DDH Sporulation-specific SASP protein KHU1_0044 ENOG4107QTZ amino acid KHU1_0048 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KHU1_0049 ENOG4105CXY transporter KHU1_0056 ENOG4107SCQ Iron-containing alcohol dehydrogenase KHU1_0057 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KHU1_0058 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KHU1_0059 ENOG4107ZTW SNARE associated Golgi KHU1_0062 ENOG4105C72 UPF0176 protein KHU1_0064 ENOG4105CM2 brancheD-chain amino acid aminotransferase KHU1_0065 ENOG4108IQI permease KHU1_0066 ENOG4108J5H Homocysteine s-methyltransferase KHU1_0068 ENOG4105CSV Glutaminase KHU1_0074 ENOG41076HS cation diffusion facilitator family transporter KHU1_0075 ENOG4108TVJ Nitroreductase KHU1_0076 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KHU1_0077 ENOG4108VGI doxx family KHU1_0078 ENOG4105XXY Thioredoxin KHU1_0081 ENOG4105DGI Alkaline phosphatase KHU1_0082 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KHU1_0083 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KHU1_0084 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) KHU1_0085 ENOG4107EPV Aminotransferase class V KHU1_0086 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHU1_0087 ENOG4105J7D transcriptional regulator KHU1_0088 ENOG4107RB3 L-asparaginase KHU1_0089 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold KHU1_0090 ENOG41060AI SEC-C motif KHU1_0091 ENOG4107SET aldo keto reductase KHU1_0097 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KHU1_0099 ENOG4105DSE periplasmic solute binding protein KHU1_0100 ENOG4105DIK (ABC) transporter KHU1_0102 ENOG4105DEN Luciferase family KHU1_0103 ENOG4108N0M stress protein KHU1_0104 ENOG4106FN3 tellurium resistance protein KHU1_0105 ENOG4106FN3 tellurium resistance protein KHU1_0106 ENOG4107TS3 membrane protein, TerC KHU1_0107 ENOG4108TTB tellurium resistance protein KHU1_0109 ENOG41079KZ Major Facilitator Superfamily KHU1_0110 ENOG4108IJ7 Glycine betaine KHU1_0111 ENOG4107SQ8 Glycine betaine KHU1_0117 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KHU1_0123 ENOG4105EIG urea carboxylase-associated protein 1 KHU1_0124 ENOG4107RA1 nh(3)-dependent nad( ) synthetase KHU1_0126 ENOG4108WBH protein TIM barrel KHU1_0127 ENOG4105DJB Major Facilitator Superfamily KHU1_0128 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) KHU1_0129 ENOG4105I82 acetyl xylan esterase KHU1_0130 ENOG410756H nucleotidyltransferase KHU1_0132 ENOG4105C26 Dehydrogenase KHU1_0133 ENOG4105CK7 Sodium proline symporter KHU1_0134 ENOG4107YHD transcriptional regulator KHU1_0135 ENOG4105CAY ferredoxin--nadp reductase KHU1_0136 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KHU1_0137 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KHU1_0138 ENOG4108IFG nitrite reductase, (NAD(P)H) KHU1_0139 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) KHU1_0142 ENOG4105CKI cobalamin synthesis protein KHU1_0143 ENOG4105E2A Dehydrogenase KHU1_0144 ENOG4105HHM rdd domain containing protein KHU1_0146 ENOG4105CS2 ec 3.2.1.21 KHU1_0149 ENOG41080HJ 6-phospho 3-hexuloisomerase KHU1_0150 ENOG4108VA3 3-hexulose-6-phosphate synthase KHU1_0151 ENOG4105KVH Transcriptional regulator KHU1_0153 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_0157 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) KHU1_0159 ENOG4105SX7 Transporter KHU1_0163 ENOG4105CDA abc transporter atp-binding protein KHU1_0164 ENOG4105DRP amino acid AbC transporter KHU1_0166 ENOG4106P55 Transcriptional regulator KHU1_0167 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase KHU1_0168 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) KHU1_0169 ENOG41069ZX KHU1_0170 ENOG41069ZX KHU1_0171 ENOG4105DUX Transporter KHU1_0174 ENOG4105E1K spore germination protein KHU1_0177 ENOG4105CPU Monooxygenase KHU1_0178 ENOG4108XSB acetyltransferase, (GNAT) family KHU1_0179 ENOG4105EAB amino acid AbC transporter KHU1_0180 ENOG4108HW4 amino acid AbC transporter KHU1_0182 ENOG4105CH2 amidohydrolase KHU1_0183 ENOG4108PGP mmge prpd family protein KHU1_0185 ENOG4107WD8 ABC transporter, permease KHU1_0186 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHU1_0187 ENOG4105BZU Histidine kinase KHU1_0190 ENOG4105CFH Aspartokinase KHU1_0191 ENOG4105DHS permease protein KHU1_0192 ENOG4105CM4 permease protein KHU1_0193 ENOG4108IPW abc transporter atp-binding protein KHU1_0196 ENOG4105R8C Transcriptional regulator KHU1_0197 ENOG4108DBC nitroreductase KHU1_0198 ENOG41067V3 Antibiotic biosynthesis monooxygenase KHU1_0199 ENOG4105YVS arsR family transcriptional regulator KHU1_0201 ENOG4108JPW Aminotransferase KHU1_0202 ENOG4105C26 Dehydrogenase KHU1_0204 ENOG4105H9W Short-chain dehydrogenase reductase Sdr KHU1_0205 ENOG4105KTB nuclear export factor GLE1 KHU1_0206 ENOG4108T5E Copper resistance protein KHU1_0207 ENOG4108ZYE Transcriptional regulator KHU1_0211 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase KHU1_0214 ENOG4105E7W lamb ycsf family protein KHU1_0215 ENOG4105C5A transporter KHU1_0216 ENOG4105CFM UPF0317 protein KHU1_0217 ENOG4105P4J Allophanate hydrolase, subunit 1 KHU1_0219 ENOG4107258 Transcriptional regulator KHU1_0220 ENOG4105XJB lipolytic protein G-D-S-L family KHU1_0221 ENOG41061CK Antibiotic biosynthesis monooxygenase KHU1_0222 ENOG4107RVG penicillin-binding protein KHU1_0223 ENOG4107QM2 Aldo Keto reductase KHU1_0224 ENOG4105ETD TRANSCRIPTIONal KHU1_0226 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHU1_0229 ENOG410606W general stress protein KHU1_0231 ENOG4105VCH membrane KHU1_0233 ENOG4105C9U ATP-dependent DNA helicase RecQ KHU1_0236 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KHU1_0237 ENOG4107R8N Glycosyl transferase, family 2 KHU1_0239 ENOG4105C0X amino acid KHU1_0243 ENOG4105X7F KHU1_0246 ENOG4105MFU Protein of unknown function (DUF2634) KHU1_0250 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KHU1_0253 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) KHU1_0254 ENOG4105RXJ KHU1_0255 ENOG4105KPY Small multidrug resistance protein KHU1_0256 ENOG4105EU9 KHU1_0257 ENOG4105QVS general stress protein KHU1_0258 ENOG41082W1 Cupin 2, conserved barrel domain protein KHU1_0261 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit KHU1_0262 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KHU1_0263 ENOG4108MRH transcriptional regulatory protein KHU1_0264 ENOG4107QJT sodium dicarboxylate symporter KHU1_0265 ENOG4106F5Q Membrane KHU1_0266 ENOG4105CJ1 ABC, transporter KHU1_0269 ENOG4105FDT acyl-CoA dehydrogenase KHU1_0271 ENOG4105SZ6 Thioredoxin KHU1_0272 ENOG4105CPF Cell wall formation (By similarity) KHU1_0273 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KHU1_0274 ENOG4105C1J atp-dependent rna helicase KHU1_0275 ENOG410905X membrane-flanked domain protein KHU1_0276 ENOG4105CKV Membrane KHU1_0278 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) KHU1_0279 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein KHU1_0280 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KHU1_0282 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KHU1_0283 ENOG4107MMM Anti-sigma-factor antagonist KHU1_0284 ENOG4105FUA antagonist KHU1_0285 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase KHU1_0286 ENOG4107SGM protein serine threonine phosphatase KHU1_0287 ENOG4105WN5 stage II sporulation protein KHU1_0288 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KHU1_0290 ENOG41064BQ Phosphatase KHU1_0292 ENOG410906U SprT-like KHU1_0295 ENOG410847I Transcriptional regulator, BadM Rrf2 family KHU1_0296 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KHU1_0297 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KHU1_0299 ENOG4105CSH Transporter KHU1_0300 ENOG4105K56 Transcriptional regulator KHU1_0302 ENOG4108ZMQ domain protein KHU1_0304 ENOG4108Z40 Transcriptional regulator KHU1_0305 ENOG4108RYK Nad-dependent epimerase dehydratase KHU1_0306 ENOG4105M4P Tetr family transcriptional regulator KHU1_0307 ENOG4105E1F short-chain dehydrogenase reductase KHU1_0308 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein KHU1_0309 ENOG4105ECK Fatty Acid Desaturase KHU1_0310 ENOG4105VEQ Cold shock protein KHU1_0311 ENOG4108VJ1 Transcriptional regulator (CarD family KHU1_0315 ENOG410645S MarR family Transcriptional regulator KHU1_0316 ENOG4105DCM major facilitator superfamily KHU1_0317 ENOG4105IRW patatin-like phospholipase family protein KHU1_0319 ENOG41082W1 Cupin 2, conserved barrel domain protein KHU1_0321 ENOG4105DNP FAD linked oxidase domain protein KHU1_0323 ENOG4105PGM cation diffusion facilitator family transporter KHU1_0324 ENOG4105H3G oxidoreductase KHU1_0326 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KHU1_0333 ENOG4105DWF phosphomethylpyrimidine kinase KHU1_0336 ENOG4105DQ4 alcohol dehydrogenase KHU1_0337 ENOG4105VUF Transcriptional regulator KHU1_0339 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHU1_0342 ENOG4105EQ0 Major Facilitator superfamily KHU1_0343 ENOG4108JGH Tetr family transcriptional regulator KHU1_0344 ENOG4105T38 integral membrane protein KHU1_0345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHU1_0348 ENOG4105E2A Dehydrogenase KHU1_0349 ENOG4105PGS Spore coat protein KHU1_0352 ENOG4105ENE Histidine kinase KHU1_0353 ENOG4108VB1 regulatoR KHU1_0354 ENOG4105EYF MMPL domain protein KHU1_0358 ENOG4108JYZ YitT family KHU1_0360 ENOG4105C2C drug resistance transporter, Bcr CflA KHU1_0361 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KHU1_0365 ENOG41090E6 transcriptional regulator MERR family KHU1_0368 ENOG4105F2W methyltransferase KHU1_0369 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KHU1_0370 ENOG4105DRR Transcriptional regulator, GntR family KHU1_0374 ENOG4105FQP Beta-lactamase KHU1_0375 ENOG41090UD (LipO)protein KHU1_0376 ENOG4108SUT Major Facilitator Superfamily KHU1_0377 ENOG4108TZY GntR Family Transcriptional Regulator KHU1_0378 ENOG4105JXH GntR family transcriptional regulator KHU1_0379 ENOG4105DJ2 Major Facilitator Superfamily KHU1_0383 ENOG4107QTZ amino acid KHU1_0387 ENOG4107QNK )-transporter KHU1_0388 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) KHU1_0389 ENOG4105K8N protein family UPF0079, ATPase KHU1_0390 ENOG41072GX Peptidase M22 Glycoprotease KHU1_0391 ENOG410801F ribosomal-protein-alanine acetyltransferase KHU1_0392 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KHU1_0393 ENOG4105C5H ABC transporter KHU1_0394 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KHU1_0395 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) KHU1_0396 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) KHU1_0397 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KHU1_0399 ENOG4108TYN CAAX amino terminal protease family protein KHU1_0400 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) KHU1_0401 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) KHU1_0403 ENOG4105PGZ NB-ARC domain KHU1_0404 ENOG4105CPQ Dehydrogenase KHU1_0405 ENOG4105CT4 transporter KHU1_0408 ENOG41087YS Phage shock protein A KHU1_0409 ENOG4105DQX Zinc finger domain KHU1_0410 ENOG4108WV1 Pfam:DUF477 KHU1_0412 ENOG4105EXC Acyl-transferase KHU1_0413 ENOG4108P49 AntiSigma factor KHU1_0414 ENOG4105JVQ RNA Polymerase KHU1_0419 ENOG4107STQ Multicopper oxidase KHU1_0420 ENOG4105C85 amino acid KHU1_0422 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KHU1_0425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KHU1_0429 ENOG4105C7N Xanthine uracil vitamin C permease KHU1_0435 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KHU1_0436 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KHU1_0437 ENOG4105C83 adenylosuccinate lyase KHU1_0438 ENOG4105C8V SAICAR synthetase KHU1_0439 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KHU1_0440 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I KHU1_0441 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii KHU1_0443 ENOG4105CXB phosphoribosylaminoimidazole synthetase KHU1_0444 ENOG4108V3E phosphoribosylglycinamide formyltransferase KHU1_0445 ENOG4105DC1 bifunctional purine biosynthesis protein purh KHU1_0446 ENOG4105C12 Phosphoribosylglycinamide synthetase KHU1_0449 ENOG4108R5T secreted protein KHU1_0450 ENOG4105KGF protein, YerC YecD KHU1_0451 ENOG4105CBC glutamate synthase KHU1_0454 ENOG4105C4R Atp-dependent dna helicase KHU1_0455 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) KHU1_0457 ENOG4105CRN Aminoglycoside phosphotransferase KHU1_0458 ENOG4105DQ6 Transposase KHU1_0460 ENOG4105KT7 mgtC SapB transporter KHU1_0461 ENOG4105CK7 Sodium proline symporter KHU1_0463 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KHU1_0464 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KHU1_0465 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) KHU1_0466 ENOG4108IG5 Transcriptional regulator KHU1_0468 ENOG4105CBD Diacylglycerol kinase KHU1_0469 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KHU1_0471 ENOG4105CJ1 ABC, transporter KHU1_0482 ENOG4105CDY transcriptional regulatory protein KHU1_0484 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KHU1_0487 ENOG4105WEF catalase KHU1_0488 ENOG4105M18 -acetyltransferase KHU1_0490 ENOG4105H67 Protein of unknown function (DUF421) KHU1_0491 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KHU1_0492 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily KHU1_0494 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein KHU1_0495 ENOG4108I5D sulfate abc transporter KHU1_0500 ENOG4106I4J membrane KHU1_0501 ENOG41082F9 transcriptional regulator KHU1_0502 ENOG41061H0 Monooxygenase KHU1_0503 ENOG4108R1P KHU1_0504 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHU1_0505 ENOG4105E0M Sulfatase KHU1_0506 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase KHU1_0508 ENOG41090R9 glycosyltransferase KHU1_0509 ENOG4107R51 Glycosyl transferase, family 2 KHU1_0510 ENOG41090R9 glycosyltransferase KHU1_0511 ENOG4105EU0 Major facilitator Superfamily KHU1_0512 ENOG4105CUB amino acid KHU1_0513 ENOG4105C26 Dehydrogenase KHU1_0514 ENOG4105FKZ Methyl-accepting chemotaxis KHU1_0515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHU1_0516 ENOG4107TVC Glycosyl transferase, family 2 KHU1_0517 ENOG4105C5H ABC transporter KHU1_0518 ENOG4107SWG transcriptional regulator MERR family KHU1_0519 ENOG4105DXB Major Facilitator superfamily KHU1_0520 ENOG4105C5H ABC transporter KHU1_0521 ENOG4105FDU atp-dependent rna helicase KHU1_0523 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein KHU1_0526 ENOG4108J20 pectate lyase KHU1_0527 ENOG4107QPK )-transporter KHU1_0533 ENOG4108MRH transcriptional regulatory protein KHU1_0538 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) KHU1_0539 ENOG4108RPX mosc domain containing protein KHU1_0541 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KHU1_0549 ENOG4105C5Y PTS System KHU1_0550 ENOG4105CG3 alpha amylase, catalytic region KHU1_0551 ENOG4107414 GntR family transcriptional regulator KHU1_0552 ENOG4108RCM Nitroreductase KHU1_0555 ENOG4105CGH 5'-nucleotidase KHU1_0556 ENOG4107RKG DJ-1/PfpI family KHU1_0557 ENOG4105ETE Transcriptional regulator (LacI family KHU1_0558 ENOG4105E2X shikimate dehydrogenase KHU1_0559 ENOG4105FF2 Type I DHQase KHU1_0562 ENOG4105KJF protein tyrosine phosphatase KHU1_0564 ENOG4107U9T Pfam:Ribonuclease_BN KHU1_0565 ENOG4108ISG Major Facilitator KHU1_0566 ENOG4105UPD Calcium Proton KHU1_0568 ENOG4105D8X mechanosensitive ion channel KHU1_0572 ENOG4106KE4 Dehydrogenase KHU1_0574 ENOG4105D7N magnesium and cobalt transport protein CorA KHU1_0576 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KHU1_0580 ENOG4107RUY (E1 component), alpha subunit KHU1_0582 ENOG4107QKR Dehydrogenase KHU1_0584 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KHU1_0586 ENOG4105F8D glycoside hydrolase family 4 KHU1_0587 ENOG4108Q3X Transcriptional regulator KHU1_0588 ENOG4105CI1 PTS System KHU1_0589 ENOG4105BZ1 (ABC) transporter KHU1_0590 ENOG4105BZ1 (ABC) transporter KHU1_0592 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KHU1_0593 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KHU1_0594 ENOG4105U3E Transcriptional regulator KHU1_0595 ENOG4105DYS nad(p)h dehydrogenase (quinone) KHU1_0596 ENOG4105H93 Acyltransferase family KHU1_0599 ENOG4108YYS metal-dependent hydrolase (By similarity) KHU1_0600 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHU1_0601 ENOG410834F Transcriptional regulator KHU1_0603 ENOG4105JAB phenazine biosynthesis protein, phzf family KHU1_0604 ENOG4107Y03 Nitroreductase KHU1_0606 ENOG4105ECP epimerase KHU1_0607 ENOG410902V Modulates RecA activity (By similarity) KHU1_0609 ENOG4105F27 Major Facilitator KHU1_0611 ENOG4108TCS Glutamyl endopeptidase KHU1_0615 ENOG4106AKJ KHU1_0616 ENOG4105D74 hydrolase KHU1_0617 ENOG4105CKK Glycosyl transferase, family 2 KHU1_0618 ENOG4105EJV Membrane KHU1_0619 ENOG41067AE Membrane-bound metal-dependent hydrolase KHU1_0620 ENOG4105CEN a g-specific adenine glycosylase KHU1_0621 ENOG4106BXE KHU1_0622 ENOG4105CAN Short-chain dehydrogenase reductase Sdr KHU1_0626 ENOG4105BZ1 (ABC) transporter KHU1_0627 ENOG4107NBY Membrane KHU1_0628 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KHU1_0629 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KHU1_0630 ENOG4105G5W regulator Fur family KHU1_0631 ENOG4105TUA UPF0295 protein KHU1_0633 ENOG4107S6Z Na H antiporter KHU1_0634 ENOG4105EC3 peptidase S51, dipeptidase E KHU1_0635 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) KHU1_0636 ENOG4105DNP FAD linked oxidase domain protein KHU1_0638 ENOG4105DEF Extracellular solute-binding protein, family 5 KHU1_0640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHU1_0641 ENOG4105C3U ABC transporter KHU1_0642 ENOG4108JQ7 (ABC) transporter KHU1_0645 ENOG4105E2Y ABC, transporter KHU1_0646 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KHU1_0647 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KHU1_0649 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) KHU1_0650 ENOG4107D63 KHU1_0651 ENOG4105VZ8 Transcriptional regulator KHU1_0653 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KHU1_0655 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KHU1_0659 ENOG4105CYN Serine protein kinase KHU1_0661 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes KHU1_0662 ENOG4105CW7 secretion protein, HlyD family KHU1_0663 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHU1_0664 ENOG4105CS1 NAD(P)H quinone oxidoreductase KHU1_0667 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KHU1_0668 ENOG4105CZV ABC transporter KHU1_0669 ENOG4105CJ1 ABC, transporter KHU1_0670 ENOG4108TU7 Inherit from COG: (ABC) transporter KHU1_0671 ENOG4105VEQ Cold shock protein KHU1_0673 ENOG4105BZU Histidine kinase KHU1_0681 ENOG4108YBP pseudouridine synthase KHU1_0683 ENOG41080XP Cbs domain KHU1_0684 ENOG4107YBY Hydrolase KHU1_0685 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KHU1_0686 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHU1_0687 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KHU1_0689 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) KHU1_0690 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KHU1_0692 ENOG4105BZU Histidine kinase KHU1_0693 ENOG4105WH1 Two component transcriptional regulator luxr family KHU1_0701 ENOG4105G6Z alkaline phosphatase KHU1_0704 ENOG4105BZN citrate synthase KHU1_0705 ENOG4105CYX Short-chain dehydrogenase reductase Sdr KHU1_0706 ENOG4105CUB amino acid KHU1_0707 ENOG4105C8J )-transporter KHU1_0709 ENOG4105J37 KHU1_0710 ENOG4108AEY RNA polymerase sigma factor KHU1_0711 ENOG4105F6E Acyl-transferase KHU1_0712 ENOG4105C37 (CBS) domain KHU1_0715 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase KHU1_0716 ENOG4105C37 (CBS) domain KHU1_0718 ENOG4105WMR Protein CrcB homolog KHU1_0719 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KHU1_0720 ENOG4105D64 Mechanosensitive ion channel KHU1_0722 ENOG4105DQ6 Transposase KHU1_0723 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KHU1_0724 ENOG4107VMI polysaccharide deacetylase KHU1_0725 ENOG4105F0I Aminotransferase KHU1_0726 ENOG4105W1N transcriptional regulator KHU1_0727 ENOG4105IIP Membrane KHU1_0729 ENOG4105BZ1 (ABC) transporter KHU1_0730 ENOG4105BZ1 (ABC) transporter KHU1_0735 ENOG410839P KHU1_0737 ENOG4106MP8 UPF0754 membrane protein KHU1_0738 ENOG4105WZB UPF0342 protein KHU1_0739 ENOG4105F1N DNA alkylation repair KHU1_0741 ENOG4105D4P Coproporphyrinogen iii oxidase KHU1_0743 ENOG4107S91 Sodium hydrogen exchanger KHU1_0744 ENOG4105NCW Trka-c domain protein KHU1_0746 ENOG4105CGU Enoyl-CoA hydratase KHU1_0748 ENOG4108IUX (ABC) transporter KHU1_0749 ENOG4105RHA ABC transporter, permease KHU1_0750 ENOG4107VRP DNA repair exonuclease KHU1_0751 ENOG4106D4I domain protein KHU1_0752 ENOG4105EQI Metal Dependent Phosphohydrolase KHU1_0754 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KHU1_0763 ENOG4105NBU tryptophan transport protein KHU1_0764 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) KHU1_0765 ENOG4105K59 histidine triad (HIT) protein KHU1_0771 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KHU1_0772 ENOG4105BZ4 penicillin-binding protein KHU1_0773 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KHU1_0774 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KHU1_0775 ENOG4105C1Q protoporphyrinogen oxidase KHU1_0777 ENOG4105ECB domain protein KHU1_0780 ENOG4105DER m42 family KHU1_0782 ENOG4108RQ5 Beta-lactamase domain-containing protein KHU1_0783 ENOG4105DF9 Lipoate-protein, ligase KHU1_0785 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_0787 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KHU1_0790 ENOG4108HUF Transporter KHU1_0791 ENOG4107TB6 phosphoglycerate mutase KHU1_0793 ENOG4107F3J Amp-dependent synthetase and ligase KHU1_0794 ENOG4107ZYJ bioY protein KHU1_0795 ENOG4106YBV Methyl-accepting chemotaxis KHU1_0799 ENOG4105XVF Competence transcription factor KHU1_0801 ENOG4108ZMX Domain of unknown function (DU1801) KHU1_0804 ENOG4105X3H Excalibur domain protein KHU1_0805 ENOG4105K8R UPF0145 protein KHU1_0806 ENOG4105E1V na solute symporter KHU1_0807 ENOG4106CAD Protein of unknown function (DUF3311) KHU1_0808 ENOG41060YP KHU1_0811 ENOG4107SCK Monooxygenase KHU1_0812 ENOG4108INS Transcriptional regulator KHU1_0813 ENOG4108KK1 membrane protein AbrB duplication KHU1_0815 ENOG4108IG5 Transcriptional regulator KHU1_0817 ENOG4108QY0 Membrane KHU1_0818 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination KHU1_0819 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KHU1_0821 ENOG4105EYH Exonuclease KHU1_0830 ENOG4105ERH Fumarylacetoacetate hydrolase KHU1_0834 ENOG4105CAQ asparagine synthetase KHU1_0836 ENOG4105UQX Mate efflux family protein KHU1_0837 ENOG4106HBX Transcriptional Regulator AraC Family KHU1_0838 ENOG4105SF0 DinB family KHU1_0839 ENOG4108ZUB Lysine exporter protein (Lyse ygga) KHU1_0840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHU1_0841 ENOG4105MYW Pentapeptide repeat protein KHU1_0842 ENOG4105MA6 gCN5-related N-acetyltransferase KHU1_0844 ENOG4108VPT UPF0234 protein KHU1_0845 ENOG4105QNR S1 RNA binding domain protein KHU1_0846 ENOG4105DIH basic membrane KHU1_0847 ENOG4105C8Q Methyl-accepting chemotaxis KHU1_0848 ENOG4107E6A Cytochrome p-450 KHU1_0849 ENOG4105EPR degv family KHU1_0850 ENOG4107AYK membrAne KHU1_0852 ENOG41073B9 KHU1_0853 ENOG4108KP7 hydrolase KHU1_0854 ENOG4108MXZ Esterase KHU1_0855 ENOG4105VG1 fes assembly suf system protein KHU1_0856 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KHU1_0857 ENOG4105IQ5 FAD linked oxidase domain protein KHU1_0859 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase KHU1_0861 ENOG4105CAS nag kinase KHU1_0862 ENOG4105C8Y Acetylornithine aminotransferase KHU1_0863 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KHU1_0865 ENOG4105DBV ornithine carbamoyltransferase KHU1_0871 ENOG4107RMD Basic membrane lipoprotein KHU1_0874 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KHU1_0875 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KHU1_0877 ENOG4105C3U ABC transporter KHU1_0878 ENOG4108JQ7 (ABC) transporter KHU1_0881 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHU1_0883 ENOG4105C31 Tryptophanyl-tRNA synthetase KHU1_0884 ENOG4108J59 Extracellular solute-binding protein, family 5 KHU1_0885 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KHU1_0886 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHU1_0888 ENOG4108JQ7 (ABC) transporter KHU1_0891 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) KHU1_0892 ENOG4108ZCF integral membrane protein KHU1_0893 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis KHU1_0895 ENOG4105DPN Oligoendopeptidase f KHU1_0897 ENOG4105T58 Dithiol-disulfide isomerase KHU1_0898 ENOG4108Z18 K06886 hemoglobin KHU1_0899 ENOG4105E4C Lytic transglycosylase catalytic KHU1_0900 ENOG4105MIX Adenylate cyclase KHU1_0903 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KHU1_0904 ENOG4105EMS pseudouridine synthase KHU1_0905 ENOG4107S1Q Phosphatase KHU1_0907 ENOG4105ETU transcriptional activator (TenA KHU1_0908 ENOG4108VEU Thiamine monophosphate synthase KHU1_0912 ENOG4105D06 uba thif-type nad fad binding protein KHU1_0913 ENOG4105DWF phosphomethylpyrimidine kinase KHU1_0914 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH KHU1_0915 ENOG4107A88 KHU1_0924 ENOG4105ENA helicase KHU1_0928 ENOG4105CJ1 ABC, transporter KHU1_0931 ENOG4108ZMI UPF0477 protein KHU1_0933 ENOG4105C28 cystathionine KHU1_0934 ENOG4105C28 cystathionine KHU1_0935 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) KHU1_0936 ENOG410635T phage-like element pbsx protein KHU1_0951 ENOG4105QBX endodeoxyribonuclease RusA KHU1_0979 ENOG4108FKH Transglycosylase SLT domain KHU1_0987 ENOG41068G1 KHU1_0992 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KHU1_0996 ENOG4106BHF KHU1_1001 ENOG4106BHF KHU1_1002 ENOG4106BHF KHU1_1011 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHU1_1014 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase KHU1_1015 ENOG4105CMR udp-glucose 4-epimerase KHU1_1016 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KHU1_1017 ENOG4105CK1 PTS System KHU1_1018 ENOG4105VCP PTS System KHU1_1025 ENOG4105KT7 mgtC SapB transporter KHU1_1030 ENOG4108IEG Formate dehydrogenase Alpha subunit KHU1_1032 ENOG4106A3M Cytochrome p-450 KHU1_1033 ENOG41087PP glycosyltransferase MGT family KHU1_1035 ENOG4105EXQ uroporphyrinogen iii synthase hem4 KHU1_1036 ENOG4105C4B ABC transporter, permease KHU1_1037 ENOG4108IXI (ABC) transporter KHU1_1039 ENOG4105Q95 Cupin 2, conserved barrel domain protein KHU1_1042 ENOG4105D2H Uronic isomerase KHU1_1043 ENOG4105CT4 transporter KHU1_1044 ENOG4107KJX Transcriptional regulator KHU1_1045 ENOG4107QZW Altronate oxidoreductase KHU1_1046 ENOG4105CTX dehydratase KHU1_1047 ENOG4107TSN permease KHU1_1050 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KHU1_1051 ENOG4105KWG Pfam:DUF1696 KHU1_1052 ENOG4105K7W phage-related replication protein KHU1_1053 ENOG410635T phage-like element pbsx protein KHU1_1061 ENOG4108TFU terminase (Small subunit) KHU1_1062 ENOG4105IG6 Phage terminase, large subunit KHU1_1063 ENOG4108MDF Phage Portal Protein KHU1_1068 ENOG41060SN KHU1_1071 ENOG4105PQS phage protein KHU1_1072 ENOG4105FR7 XkdM protein, phage-like element PBSX KHU1_1073 ENOG4105MTC XkdN-like protein KHU1_1074 ENOG4108FKH Transglycosylase SLT domain KHU1_1074 ENOG4108FKH Transglycosylase SLT domain KHU1_1074 ENOG4108FKH Transglycosylase SLT domain KHU1_1075 ENOG4108WZM domain protein KHU1_1076 ENOG4105X7F KHU1_1078 ENOG4105MFU Protein of unknown function (DUF2634) KHU1_1079 ENOG41066EA baseplate J family protein KHU1_1080 ENOG410906S phage-like element pbsx protein xkdt KHU1_1082 ENOG41068G1 KHU1_1088 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KHU1_1091 ENOG4105CJ3 phosphate transporter KHU1_1092 ENOG4107GRR phosphate transport regulator KHU1_1093 ENOG4107R7I amino acid KHU1_1095 ENOG4105EDW glycosyl transferase, family 39 KHU1_1096 ENOG4105CKK Glycosyl transferase, family 2 KHU1_1097 ENOG4105C0H protease KHU1_1099 ENOG4108ME1 Peptidase M55 D-aminopeptidase KHU1_1100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KHU1_1101 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KHU1_1102 ENOG4105C3U ABC transporter KHU1_1104 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KHU1_1105 ENOG4105DTQ mandelate racemase muconate lactonizing KHU1_1106 ENOG4107SN7 NLP P60 protein KHU1_1107 ENOG4108JQ7 (ABC) transporter KHU1_1108 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KHU1_1109 ENOG4107TUM Amidinotransferase KHU1_1110 ENOG4108S4H thioesterase Superfamily protein KHU1_1111 ENOG4108428 Inherit from COG: -acetyltransferase KHU1_1113 ENOG41080TC multidrug resistance protein KHU1_1114 ENOG4105CIY formyltetrahydrofolate deformylase KHU1_1115 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KHU1_1118 ENOG4105K56 Transcriptional regulator KHU1_1119 ENOG4108ZHJ Organic hydroperoxide resistance protein KHU1_1122 ENOG4107TVC Glycosyl transferase, family 2 KHU1_1124 ENOG4105D8G Major Facilitator superfamily KHU1_1125 ENOG4108Y4K DNA-binding transcriptional activator KHU1_1126 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) KHU1_1127 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHU1_1129 ENOG4108W7F transporter, permease KHU1_1130 ENOG4108JJB ABC transporter KHU1_1131 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein KHU1_1133 ENOG4105VRS hydrolase family 18 KHU1_1134 ENOG4105CJW magnesium transporter KHU1_1135 ENOG4105V75 Transcriptional regulator KHU1_1139 ENOG4105DQE DNA ligase KHU1_1140 ENOG4105FDF Could be involved in DNA repair (By similarity) KHU1_1141 ENOG4107T5V SNARE associated Golgi KHU1_1142 ENOG4107TS3 membrane protein, TerC KHU1_1143 ENOG4108WZW RNA polymerase sigma KHU1_1145 ENOG410681C small acid-soluble spore protein KHU1_1147 ENOG4105D0M Protease HtpX homolog KHU1_1149 ENOG410900G Protein of unknown function (DUF421) KHU1_1150 ENOG4108TGC Acyltransferase KHU1_1151 ENOG4105BZU Histidine kinase KHU1_1152 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KHU1_1153 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KHU1_1155 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KHU1_1157 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate KHU1_1159 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) KHU1_1160 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KHU1_1163 ENOG41090MY MarR family Transcriptional regulator KHU1_1164 ENOG4105ER2 Ompa motb domain protein KHU1_1165 ENOG4105E14 MotA TolQ exbB proton channel KHU1_1168 ENOG4108K88 Membrane KHU1_1170 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) KHU1_1171 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase KHU1_1172 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KHU1_1173 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KHU1_1175 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr KHU1_1176 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) KHU1_1177 ENOG4105FEA Spore maturation protein KHU1_1183 ENOG4105F0V Cell wall hydrolase KHU1_1186 ENOG4105C59 p-type ATPase KHU1_1187 ENOG4105DC7 peptidase M24 KHU1_1189 ENOG4105CID antiterminator KHU1_1191 ENOG4105KRI phosphocarrier protein (HPr KHU1_1192 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KHU1_1194 ENOG4105F6S Spore photoproduct lyase KHU1_1195 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KHU1_1196 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KHU1_1197 ENOG4105K4I Scp-like extracellular KHU1_1199 ENOG4105BZU Histidine kinase KHU1_1200 ENOG4105CHM Aminotransferase KHU1_1201 ENOG4107R88 Chemotaxis protein (CheV) KHU1_1202 ENOG4105UIN KHU1_1204 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein KHU1_1206 ENOG4105K6S Short-chain dehydrogenase reductase Sdr KHU1_1208 ENOG4105EPM Diguanylate phosphodiesterase KHU1_1209 ENOG4107IN1 Protein of unknown function (DUF1797) KHU1_1210 ENOG4108XRC Protein of unknown function (DUF458) KHU1_1216 ENOG4105NQC Flavodoxin KHU1_1220 ENOG4105D8X mechanosensitive ion channel KHU1_1221 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KHU1_1224 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) KHU1_1225 ENOG4105D06 uba thif-type nad fad binding protein KHU1_1226 ENOG4105CVM Molybdenum cofactor synthesis domain protein KHU1_1227 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KHU1_1228 ENOG4108ZAF Molybdopterin KHU1_1229 ENOG41067WU Molybdopterin converting factor (Subunit 1) KHU1_1231 ENOG4107X8C Efflux transporter RND family MFP subunit KHU1_1232 ENOG4105C19 ABC transporter KHU1_1233 ENOG4107RBB ABC transporter, permease KHU1_1234 ENOG4105E98 transcriptional regulator DeoR family KHU1_1235 ENOG4105DE4 1-phosphofructokinase KHU1_1236 ENOG4105DM4 PTS System KHU1_1239 ENOG4105C5H ABC transporter KHU1_1240 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KHU1_1245 ENOG4105BZU Histidine kinase KHU1_1247 ENOG4107ZYR domain protein KHU1_1248 ENOG4105CPN adenine deaminase KHU1_1249 ENOG4105CN5 Metallo-Beta-Lactamase KHU1_1250 ENOG4106148 UPF0356 protein KHU1_1251 ENOG4108X4Q Hydrolase KHU1_1252 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KHU1_1256 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KHU1_1257 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1258 ENOG4107SQU synthase KHU1_1259 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1260 ENOG4107SQU synthase KHU1_1261 ENOG4107SQU synthase KHU1_1262 ENOG4107SQU synthase KHU1_1263 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1264 ENOG4105FQP Beta-lactamase KHU1_1266 ENOG4105CPP Dehydrogenase, E1 component KHU1_1267 ENOG4105C7S Dehydrogenase KHU1_1268 ENOG4107QN2 dihydrolipoyl dehydrogenase KHU1_1271 ENOG4105CXN decarboxylase KHU1_1272 ENOG4105WBI UPF0223 protein KHU1_1275 ENOG4105ECY inositol monophosphatase KHU1_1277 ENOG4105D4Y metalloprotease KHU1_1280 ENOG4105CI3 gtp-binding protein typa KHU1_1281 ENOG4105QA2 KHU1_1284 ENOG4108IAB Phoh family KHU1_1286 ENOG4105CSV Glutaminase KHU1_1288 ENOG4105CNI cell division protein FtsW KHU1_1289 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KHU1_1291 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) KHU1_1293 ENOG4105BZ9 Cytochrome C oxidase, subunit I KHU1_1294 ENOG4105CCU oxidase (Subunit III) KHU1_1295 ENOG41064X9 cytochrome C oxidase subunit IV KHU1_1298 ENOG41080XQ Signal transduction protein with cbs domains KHU1_1299 ENOG4106UY4 Inherit from COG: Scp-like extracellular KHU1_1305 ENOG4106H78 methyltransferase KHU1_1306 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) KHU1_1307 ENOG4105H20 Sporulation integral membrane protein YlbJ KHU1_1308 ENOG4105D78 K07001 NTE family protein KHU1_1309 ENOG41063PX domain protein KHU1_1310 ENOG4105CDE UPF0348 protein KHU1_1311 ENOG4105KNH Nucleic acid-binding protein KHU1_1312 ENOG41067VY 50S ribosomal protein L32 KHU1_1317 ENOG4108V6E Cell division protein mraZ KHU1_1318 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) KHU1_1320 ENOG4105CJN penicillin-binding protein KHU1_1321 ENOG4105CJN penicillin-binding protein KHU1_1322 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KHU1_1323 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) KHU1_1324 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) KHU1_1325 ENOG4105CNI cell division protein FtsW KHU1_1326 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KHU1_1327 ENOG4105D4A Cell wall formation (By similarity) KHU1_1328 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KHU1_1329 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KHU1_1330 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KHU1_1332 ENOG4105FFI sigma-e processing peptidase spoiiga KHU1_1333 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHU1_1335 ENOG4105DKW ABC transporter KHU1_1337 ENOG4105WR5 sporulation protein, YlmC YmxH family KHU1_1338 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KHU1_1339 ENOG4105DFA alanine racemase domain protein KHU1_1340 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) KHU1_1341 ENOG41067XK integral membrane protein KHU1_1342 ENOG4105DBK s4 domain protein KHU1_1344 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KHU1_1346 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) KHU1_1347 ENOG4105C34 Pseudouridine synthase KHU1_1348 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) KHU1_1350 ENOG4105CXT aspartate transcarbamylase KHU1_1352 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KHU1_1353 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain KHU1_1354 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) KHU1_1355 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) KHU1_1356 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) KHU1_1357 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) KHU1_1360 ENOG4107RIQ Sulfate adenylate transferase KHU1_1362 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KHU1_1363 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KHU1_1364 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KHU1_1365 ENOG4105F23 Fibronectin-binding protein KHU1_1367 ENOG4105DSJ YicC domain protein KHU1_1368 ENOG4105KC4 UPF0296 protein KHU1_1369 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) KHU1_1371 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KHU1_1373 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KHU1_1374 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) KHU1_1375 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KHU1_1376 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs KHU1_1377 ENOG4108ZF3 Phosphatase KHU1_1378 ENOG4105D9P serine threonine protein kinase KHU1_1379 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KHU1_1381 ENOG4105FJ0 thiamine KHU1_1382 ENOG4105VB9 50S ribosomal protein l28 KHU1_1383 ENOG4108ZAA Alkaline-shock protein KHU1_1384 ENOG4105DP4 dak2 domain fusion protein ylov KHU1_1386 ENOG4105EJQ L-serine dehydratase KHU1_1387 ENOG4105CB5 ATP-dependent DNA helicase recG KHU1_1388 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) KHU1_1389 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) KHU1_1390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KHU1_1391 ENOG4105CHR reductase KHU1_1392 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) KHU1_1393 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) KHU1_1394 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) KHU1_1395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KHU1_1397 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) KHU1_1399 ENOG4105K5M 30s ribosomal protein S16 KHU1_1400 ENOG4108BW8 UPF0109 protein KHU1_1403 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) KHU1_1404 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) KHU1_1405 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KHU1_1406 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KHU1_1408 ENOG4105VM1 flagellar KHU1_1409 ENOG4105CMV Succinyl-CoA synthetase subunit beta KHU1_1410 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KHU1_1411 ENOG4105C79 DNA protecting protein DprA KHU1_1412 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KHU1_1413 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) KHU1_1414 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KHU1_1415 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) KHU1_1416 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) KHU1_1418 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) KHU1_1419 ENOG4108ZC9 flagellar basal-body rod protein flgc KHU1_1420 ENOG4105VQ0 flagellar hook-basal body complex protein fliE KHU1_1421 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) KHU1_1422 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KHU1_1425 ENOG4106YF4 Flagellar biosynthesis chaperone KHU1_1427 ENOG410696Y Flagellar hook-length control protein KHU1_1428 ENOG410822I Flagellar hook capping protein KHU1_1429 ENOG4108JQA flagellar KHU1_1430 ENOG41068WV flagellar FlbD family protein KHU1_1432 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KHU1_1433 ENOG4105DD5 Flagellar motor switch protein KHU1_1434 ENOG4107YTP response regulator receiver protein KHU1_1436 ENOG4105CN7 Flagellar biosynthetic protein FliP KHU1_1437 ENOG4105VS8 Flagellar biosynthetic protein fliq KHU1_1439 ENOG4105D00 flagellar biosynthetic protein flhB KHU1_1440 ENOG4105D7B Flagellar biosynthesis protein flha KHU1_1441 ENOG4105FZW flagellar biosynthesis regulator FlhF KHU1_1443 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) KHU1_1444 ENOG4105CBS Chea signal transduction histidine kinase KHU1_1445 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis KHU1_1447 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) KHU1_1448 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHU1_1450 ENOG4105CE9 30S ribosomal protein S2 KHU1_1452 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) KHU1_1453 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) KHU1_1454 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KHU1_1455 ENOG4105KNE Phosphatidate cytidylyltransferase KHU1_1457 ENOG4105DZP Membrane-associated zinc metalloprotease KHU1_1458 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) KHU1_1459 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KHU1_1460 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) KHU1_1461 ENOG4105CHV Transcription elongation factor NusA KHU1_1462 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KHU1_1463 ENOG4105VHM ribosomal protein KHU1_1464 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) KHU1_1465 ENOG4105W7A Protein of unknown function (DUF503) KHU1_1466 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) KHU1_1467 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KHU1_1468 ENOG4105DTN riboflavin biosynthesis protein ribF KHU1_1469 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) KHU1_1470 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) KHU1_1472 ENOG4105C1V Peptidase, M16 KHU1_1474 ENOG4105E35 Dipicolinate synthase subunit A KHU1_1475 ENOG4108S0H Dipicolinic acid synthetase, b subunit KHU1_1476 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KHU1_1478 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KHU1_1480 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KHU1_1482 ENOG4105CNU cell division protein FtsK KHU1_1483 ENOG4105FDP GntR family transcriptional regulator KHU1_1486 ENOG4105EYF MMPL domain protein KHU1_1489 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KHU1_1490 ENOG4105XZV Protein of unknown function (DUF3243) KHU1_1493 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KHU1_1494 ENOG4105CEV competence damage-inducible protein KHU1_1495 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) KHU1_1496 ENOG4108A04 Beta-lactamase KHU1_1498 ENOG4105D48 metallophosphoesterase KHU1_1499 ENOG4105MCT stage V sporulation protein S KHU1_1500 ENOG4105CPQ Dehydrogenase KHU1_1501 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KHU1_1502 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KHU1_1506 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) KHU1_1507 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) KHU1_1512 ENOG4108151 Beta-lactamase domain protein KHU1_1513 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KHU1_1514 ENOG4108JA1 polyketide synthase KHU1_1515 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KHU1_1516 ENOG41062T2 Acyl carrier protein KHU1_1517 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KHU1_1518 ENOG4108MGH Enoyl-CoA hydratase KHU1_1519 ENOG4108KQ6 Enoyl-CoA hydratase KHU1_1520 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1521 ENOG4107SQU synthase KHU1_1523 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1525 ENOG4106A3M Cytochrome p-450 KHU1_1526 ENOG4105WFK nuclease KHU1_1527 ENOG4105XPP Protein of unknown function (DUF1275) KHU1_1529 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin KHU1_1531 ENOG4105K7W phage-related replication protein KHU1_1532 ENOG4108X3M OsmC Ohr family protein KHU1_1542 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KHU1_1544 ENOG4105U6W MutT NUDIX family protein KHU1_1547 ENOG4106F1P AAA ATPase, central domain protein KHU1_1548 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KHU1_1549 ENOG4105CXI aluminum resistance protein KHU1_1550 ENOG4105KV4 Transcriptional regulator KHU1_1551 ENOG4105C5F glutamine synthetase KHU1_1553 ENOG4105CT4 transporter KHU1_1554 ENOG4105DSG hydrolase family 43 KHU1_1556 ENOG4105C93 Xylose Isomerase KHU1_1557 ENOG4105CMG Carbohydrate kinase KHU1_1558 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KHU1_1562 ENOG4105DQ4 alcohol dehydrogenase KHU1_1564 ENOG4105EPI acetyltransferase, (GNAT) family KHU1_1572 ENOG4108M1A Chitin-binding protein KHU1_1575 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KHU1_1576 ENOG4105K7W phage-related replication protein KHU1_1580 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) KHU1_1582 ENOG4108SVB resolvase KHU1_1583 ENOG4105VPS UPF0291 protein KHU1_1584 ENOG4105CV1 Transketolase (EC 2.2.1.1) KHU1_1586 ENOG4105VXM UPF0154 protein KHU1_1588 ENOG4107QIV Cytochrome c biogenesis protein KHU1_1595 ENOG4108I0Z Aconitate hydratase KHU1_1596 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KHU1_1599 ENOG41067CD Small, acid-soluble spore protein Tlp KHU1_1601 ENOG4105MI2 KHU1_1602 ENOG4105W8X HesB YadR YfhF-family protein KHU1_1603 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KHU1_1604 ENOG4105K4P CoA-binding domain protein KHU1_1605 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHU1_1610 ENOG4105CPQ Dehydrogenase KHU1_1611 ENOG4108UHU Aldolase KHU1_1612 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) KHU1_1613 ENOG4105DMW Dehydrogenase reductase KHU1_1615 ENOG4108I5G Major Facilitator superfamily KHU1_1618 ENOG4105FVX KHU1_1624 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHU1_1626 ENOG4107SYN Glycosyl hydrolases family 43 KHU1_1631 ENOG4105DTD Dehydrogenase KHU1_1632 ENOG4108IIH CoA-transferase subunit B KHU1_1633 ENOG4105D6N CoA-transferase, subunit a KHU1_1634 ENOG4105CY2 Citrate transporter KHU1_1635 ENOG4106A3M Cytochrome p-450 KHU1_1636 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KHU1_1637 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) KHU1_1638 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KHU1_1639 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHU1_1640 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) KHU1_1642 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KHU1_1643 ENOG4107T5V SNARE associated Golgi KHU1_1644 ENOG4107QX3 carboxylase KHU1_1645 ENOG4105E39 Enoyl-CoA hydratase KHU1_1646 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KHU1_1647 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KHU1_1648 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KHU1_1649 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_1650 ENOG4105C1G acyl-Coa dehydrogenase KHU1_1651 ENOG4105F32 YngK protein KHU1_1652 ENOG4106U2H Protein of unknown function (DUF1360) KHU1_1655 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1658 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family KHU1_1659 ENOG4108N2V aldose 1-epimerase KHU1_1660 ENOG4107QJQ Mate efflux family protein KHU1_1664 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KHU1_1665 ENOG4108RWP Major Facilitator Superfamily protein KHU1_1666 ENOG4105WAB arsR family transcriptional regulator KHU1_1667 ENOG4105C22 threonyL-tRNA synthetase KHU1_1668 ENOG4108KSA LysR family transcriptional regulator KHU1_1669 ENOG4105CB2 alcohol dehydrogenase KHU1_1670 ENOG4105BZ8 glutamate synthase KHU1_1671 ENOG4105CBC glutamate synthase KHU1_1672 ENOG4105C5Q Transcriptional regulator KHU1_1673 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KHU1_1678 ENOG4108UB7 KHU1_1679 ENOG4105IE8 Alpha-ketoglutarate permease KHU1_1680 ENOG4107U6E carbohydrate kinase FGGY KHU1_1681 ENOG4108M3J Dehydrogenase KHU1_1682 ENOG4108J2R molybdopterin oxidoreductase KHU1_1687 ENOG4106ANW SMI1_KNR4 KHU1_1688 ENOG4106BHF KHU1_1689 ENOG4108Z7R Chaperone CsaA KHU1_1690 ENOG4105FTV AraC Family Transcriptional Regulator KHU1_1692 ENOG4108W8B Beta-lactamase domain protein KHU1_1694 ENOG4105KTU Transcriptional regulator, arsr family KHU1_1696 ENOG4108SJC Membrane KHU1_1701 ENOG41069ER domain protein KHU1_1702 ENOG4105C9U ATP-dependent DNA helicase RecQ KHU1_1703 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KHU1_1704 ENOG4105SCY DNAK suppressor KHU1_1712 ENOG4105C26 Dehydrogenase KHU1_1713 ENOG4105EWU Squalene--hopene cyclase KHU1_1714 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KHU1_1715 ENOG4105C8J )-transporter KHU1_1716 ENOG4105C09 Bile acid KHU1_1718 ENOG4105C7S Dehydrogenase KHU1_1719 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 KHU1_1720 ENOG4107T89 von Willebrand factor, type A KHU1_1721 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KHU1_1723 ENOG4105K4H Nlp p60 protein KHU1_1724 ENOG41087PP glycosyltransferase MGT family KHU1_1726 ENOG4107QMU Mate efflux family protein KHU1_1727 ENOG4106SCS STAS domain KHU1_1731 ENOG4105FR1 rard protein KHU1_1734 ENOG41090U3 tautomerase KHU1_1738 ENOG4105FBA Phospholipase Carboxylesterase KHU1_1741 ENOG4105E1V na solute symporter KHU1_1743 ENOG4105CS2 ec 3.2.1.21 KHU1_1744 ENOG4108S3Y transcriptional regulator KHU1_1748 ENOG4108VXD carboxy-peptidase KHU1_1749 ENOG4105D3A purine nucleoside phosphorylase DeoD-type KHU1_1750 ENOG4106Z5R KHU1_1751 ENOG410841Q phosphoesterase PA-phosphatase related protein KHU1_1758 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KHU1_1759 ENOG4108TSC N-acetyltransferase KHU1_1760 ENOG4107S4Y M20 DapE family protein YgeY KHU1_1763 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KHU1_1764 ENOG4105FTQ Dna gyrase KHU1_1771 ENOG4105C5E polysaccharide biosynthesis protein KHU1_1772 ENOG4105E0X reductase KHU1_1773 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KHU1_1775 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) KHU1_1776 ENOG41090WU lipolytic protein G-D-S-L family KHU1_1777 ENOG4108KF3 Electron transport protein SCO1 SenC KHU1_1781 ENOG4108UT2 hemolysin iii KHU1_1783 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) KHU1_1784 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) KHU1_1786 ENOG4107YX5 Pfam:DUF548 KHU1_1787 ENOG4108Y6J UPF0403 protein KHU1_1788 ENOG4105C01 Dihydroxy-acid dehydratase KHU1_1791 ENOG4108V06 Glutathione peroxidase KHU1_1792 ENOG4105CVG Homoserine O-transsuccinylase KHU1_1800 ENOG41081VK Ribonuclease KHU1_1804 ENOG410890F Dynamin family KHU1_1806 ENOG41065KQ synthase KHU1_1810 ENOG410900G Protein of unknown function (DUF421) KHU1_1811 ENOG410900G Protein of unknown function (DUF421) KHU1_1814 ENOG4105C2W permease KHU1_1815 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) KHU1_1816 ENOG4105CTD carboxy-peptidase KHU1_1819 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KHU1_1820 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) KHU1_1821 ENOG4108UKS UPF0398 protein KHU1_1823 ENOG4107X2U Inherit from COG: Exonuclease-like protein KHU1_1824 ENOG4108I5C dEAD DEAH box helicase KHU1_1832 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) KHU1_1833 ENOG4105BZ4 penicillin-binding protein KHU1_1835 ENOG4105CSM endonuclease III KHU1_1837 ENOG4105C5S asparaginyl-tRNA synthetase KHU1_1840 ENOG4105DVT helicase KHU1_1841 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) KHU1_1843 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) KHU1_1845 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate KHU1_1846 ENOG4105CPK Glycosyl transferase (Group 1 KHU1_1847 ENOG4105FJR Lmbe family KHU1_1848 ENOG4108Z5K methylglyoxal synthase KHU1_1849 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) KHU1_1850 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KHU1_1851 ENOG4108JYZ YitT family KHU1_1852 ENOG4105F0F Oxalate decarboxylase KHU1_1856 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KHU1_1860 ENOG41068YB TPR repeat-containing protein KHU1_1862 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase KHU1_1864 ENOG4105CIH Imidazole acetol-phosphate transaminase KHU1_1866 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) KHU1_1867 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase KHU1_1868 ENOG4105DK0 Indole-3-glycerol phosphate synthase KHU1_1870 ENOG4105CRQ synthase (Component I) KHU1_1871 ENOG4105KHN chorismate mutase KHU1_1873 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KHU1_1874 ENOG4105BZU Histidine kinase KHU1_1875 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) KHU1_1876 ENOG4105EAH synthase KHU1_1877 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KHU1_1878 ENOG4105XXQ heptaprenyl diphosphate synthase component I KHU1_1879 ENOG4105WP2 Tryptophan RNA-binding attenuator protein KHU1_1880 ENOG4105EUJ GTP cyclohydrolase i KHU1_1881 ENOG4105K70 DNA-binding protein KHU1_1882 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KHU1_1885 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase KHU1_1886 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) KHU1_1889 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) KHU1_1890 ENOG4105CAT Cytidine monophosphate kinase KHU1_1893 ENOG4105MSI germination protein ypeb KHU1_1895 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) KHU1_1896 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KHU1_1899 ENOG4107RGJ metallophosphoesterase KHU1_1902 ENOG4105I7S Abortive infection protein KHU1_1903 ENOG4105C9U ATP-dependent DNA helicase RecQ KHU1_1904 ENOG4105T7X KHU1_1906 ENOG4108SAX Membrane KHU1_1907 ENOG4108JQ1 Dehydrogenase KHU1_1910 ENOG4105BZU Histidine kinase KHU1_1911 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHU1_1912 ENOG4105CRE cytochrome C KHU1_1913 ENOG4107TWT Cytochrome c biogenesis protein KHU1_1915 ENOG4105FE9 pseudouridine synthase KHU1_1917 ENOG4108JIC nucleoside recognition domain protein KHU1_1918 ENOG4105DZ1 carboxypeptidase KHU1_1920 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) KHU1_1921 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) KHU1_1924 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) KHU1_1925 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) KHU1_1926 ENOG4108R6K riboflavin synthase, subunit alpha KHU1_1931 ENOG4107ZE5 PPIases accelerate the folding of proteins KHU1_1932 ENOG4105PTM secreted protein KHU1_1933 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KHU1_1935 ENOG4105G6R Stage v sporulation protein ae KHU1_1937 ENOG4105CZ3 stage V sporulation protein ad KHU1_1938 ENOG41090VF Stage v sporulation protein ac KHU1_1941 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHU1_1942 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) KHU1_1943 ENOG41082AN stage II sporulation protein KHU1_1944 ENOG4105DZ1 carboxypeptidase KHU1_1945 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) KHU1_1946 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) KHU1_1947 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KHU1_1949 ENOG4105I3K Ferric uptake regulator, Fur family KHU1_1950 ENOG4105MZ9 stage II sporulation protein m KHU1_1954 ENOG4105DFD Na H antiporter KHU1_1955 ENOG4108IJ0 Aspartate ammonia-lyase KHU1_1956 ENOG4105HDK L-asparaginase KHU1_1957 ENOG4108IMY Transcriptional regulator KHU1_1959 ENOG4108YZ4 nudix hydrolase KHU1_1960 ENOG4105CPC Aldo Keto reductase KHU1_1964 ENOG4106HZJ KHU1_1965 ENOG4105RHY Pfam:UPF0157 KHU1_1966 ENOG4105KAC Antibiotic biosynthesis monooxygenase KHU1_1967 ENOG4108XET gCN5-related N-acetyltransferase KHU1_1968 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KHU1_1971 ENOG4105C02 permease KHU1_1972 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase KHU1_1973 ENOG4105CS9 pantothenic acid kinase KHU1_1975 ENOG4108IXY short-chain dehydrogenase reductase KHU1_1976 ENOG41069FQ Metallo-beta-lactamase superfamily KHU1_1977 ENOG4105II7 pyrroline-5-carboxylate reductase KHU1_1978 ENOG4108KQ6 Enoyl-CoA hydratase KHU1_1979 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase KHU1_1980 ENOG4106A3M Cytochrome p-450 KHU1_1983 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1984 ENOG4105C0W non-ribosomal peptide synthetase KHU1_1987 ENOG4107SQU synthase KHU1_1988 ENOG4105CHR reductase KHU1_1989 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_1992 ENOG4107QKG PfaD family KHU1_1993 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KHU1_1994 ENOG4108K70 Transcriptional regulator KHU1_1996 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KHU1_1998 ENOG410861F 50S ribosomal protein L33 KHU1_1999 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KHU1_2000 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KHU1_2001 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KHU1_2002 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KHU1_2004 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) KHU1_2005 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KHU1_2006 ENOG4108HNZ carboxyl transferase KHU1_2007 ENOG4108ZVT methylmalonyl-coA epimerase KHU1_2008 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KHU1_2009 ENOG4108QEG Membrane KHU1_2010 ENOG4105CDA abc transporter atp-binding protein KHU1_2011 ENOG4105E5Q amino acid AbC transporter KHU1_2012 ENOG4108HW3 (ABC) transporter KHU1_2014 ENOG4105DQ6 Transposase KHU1_2015 ENOG4108Y6J UPF0403 protein KHU1_2016 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KHU1_2017 ENOG4105C7S Dehydrogenase KHU1_2018 ENOG4105CPP Dehydrogenase, E1 component KHU1_2021 ENOG4105CKM Branched-chain carboxylic acid kinase KHU1_2022 ENOG4107RDP Dehydrogenase KHU1_2024 ENOG4108JUB Transcriptional regulator KHU1_2025 ENOG4106CCJ Protein of unknown function (DUF2627) KHU1_2026 ENOG4105CR4 methylisocitrate lyase KHU1_2027 ENOG4105DXD 2-methylcitrate dehydratase KHU1_2029 ENOG4105C1G acyl-Coa dehydrogenase KHU1_2030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KHU1_2032 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KHU1_2033 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHU1_2038 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KHU1_2041 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KHU1_2042 ENOG4107QQR Sporulation KHU1_2043 ENOG4105S1Z Stage IV sporulation protein B KHU1_2044 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KHU1_2045 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) KHU1_2046 ENOG4105DX0 Hemolysin A KHU1_2048 ENOG4105CTB Polyprenyl synthetase KHU1_2049 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KHU1_2050 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) KHU1_2051 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) KHU1_2052 ENOG4105M7K Involved in the transcription termination process (By similarity) KHU1_2053 ENOG4108ZSR alkaline shock protein KHU1_2054 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KHU1_2058 ENOG410644B Stage III sporulation protein af KHU1_2060 ENOG4105KQ4 Stage iii sporulation protein ad KHU1_2061 ENOG4108CQH stage III sporulation protein AC KHU1_2062 ENOG4105KR5 Stage iii sporulation protein KHU1_2063 ENOG4105CD2 stage iii sporulation protein aa KHU1_2065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) KHU1_2066 ENOG4105DC7 peptidase M24 KHU1_2068 ENOG4105CBJ Metal-dependent enzyme KHU1_2072 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KHU1_2073 ENOG4105WZW rhodanese family KHU1_2074 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor KHU1_2076 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) KHU1_2077 ENOG4105C0D helicase KHU1_2080 ENOG4108IMY Transcriptional regulator KHU1_2082 ENOG4105VFR signal peptidase KHU1_2094 ENOG4105C37 (CBS) domain KHU1_2098 ENOG4105C5X domain protein KHU1_2105 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KHU1_2106 ENOG4105WDJ 50S ribosomal protein L33 KHU1_2108 ENOG41068DG YceG-like family KHU1_2109 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KHU1_2110 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KHU1_2111 ENOG4105E2Z phosphate ABC transporter (Permease KHU1_2112 ENOG4105C8U phosphate abc transporter KHU1_2113 ENOG4105CVA phosphate KHU1_2114 ENOG4107RF6 penicillin-binding protein KHU1_2116 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KHU1_2117 ENOG4105SXS Protein of unknown function (DUF456) KHU1_2120 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) KHU1_2121 ENOG41063Y9 KHU1_2122 ENOG4108U5J '-nucleotidase KHU1_2123 ENOG4105N80 Ferric uptake regulator, Fur family KHU1_2124 ENOG4108JYZ YitT family KHU1_2125 ENOG41069ZM Protein of unknown function (DUF2624) KHU1_2126 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) KHU1_2129 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) KHU1_2130 ENOG4105EGD dinuclear metal center protein, YbgI family KHU1_2133 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHU1_2134 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KHU1_2135 ENOG4108UPT UPF0178 protein KHU1_2136 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) KHU1_2138 ENOG4105C38 Glycyl-tRNA synthetase beta subunit KHU1_2139 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit KHU1_2140 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) KHU1_2142 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KHU1_2143 ENOG4105KG3 cytidine deaminase KHU1_2144 ENOG4107YR5 Diacylglycerol kinase KHU1_2145 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) KHU1_2146 ENOG4105CTJ Metal Dependent Phosphohydrolase KHU1_2147 ENOG4105C9A Phoh family KHU1_2148 ENOG4105EI1 sporulation protein yqfd KHU1_2149 ENOG41068P3 sporulation protein YqfC KHU1_2151 ENOG4105DI5 UPF0365 protein KHU1_2152 ENOG4105F7J membrane-bound serine protease KHU1_2153 ENOG4105KTH gatB Yqey KHU1_2156 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KHU1_2157 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KHU1_2158 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) KHU1_2159 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) KHU1_2160 ENOG4105CFG Acts as a chaperone (By similarity) KHU1_2161 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KHU1_2162 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) KHU1_2163 ENOG4105CSA Coproporphyrinogen iii oxidase KHU1_2164 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) KHU1_2166 ENOG4108ZRV stage ii sporulation protein p KHU1_2167 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) KHU1_2168 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) KHU1_2169 ENOG4105TQK DNA polymerase iii, delta' subunit KHU1_2170 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KHU1_2171 ENOG4108UK2 deaminase KHU1_2172 ENOG4105KQC Competence protein KHU1_2174 ENOG4108D32 Methyltransferase KHU1_2176 ENOG4108WF2 Metal Dependent Phosphohydrolase KHU1_2177 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) KHU1_2178 ENOG410812S Rna-binding protein KHU1_2179 ENOG4105E2X shikimate dehydrogenase KHU1_2180 ENOG4105CQW ribosome biogenesis GTPase YqeH KHU1_2181 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KHU1_2185 ENOG41080BT SNARE associated Golgi KHU1_2191 ENOG4106BHF KHU1_2194 ENOG41086D8 Transcriptional regulator KHU1_2196 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KHU1_2197 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KHU1_2198 ENOG4108J8C transporter major facilitator family protein KHU1_2199 ENOG4108U7W acetyltransferase KHU1_2202 ENOG4108HCJ Hydrolase KHU1_2203 ENOG4108HCJ Hydrolase KHU1_2205 ENOG4105DG6 mannose-6-phosphate isomerase KHU1_2206 ENOG4105DM4 PTS System KHU1_2209 ENOG4108Z66 YbaK ebsC protein KHU1_2210 ENOG4107RSM transcriptional regulator KHU1_2211 ENOG4105D94 Major Facilitator Superfamily KHU1_2212 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHU1_2213 ENOG41082JN Transcriptional regulator KHU1_2216 ENOG4105TMB Formate nitrite transporter KHU1_2217 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KHU1_2218 ENOG4108JB9 formate dehydrogenase KHU1_2221 ENOG4105C28 cystathionine KHU1_2227 ENOG4107XRG penicillin-binding protein KHU1_2228 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) KHU1_2230 ENOG4105CFP Peptidase U32 KHU1_2231 ENOG4105XYU peptidase (U32 family) KHU1_2232 ENOG4108VQJ O-methyltransferase KHU1_2233 ENOG4105HHA aminodeoxychorismate lyase KHU1_2235 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) KHU1_2236 ENOG4105VBH UPF0297 protein KHU1_2237 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KHU1_2238 ENOG4105C02 permease KHU1_2239 ENOG4105CDA abc transporter atp-binding protein KHU1_2240 ENOG4105CT1 (ABC) transporter KHU1_2241 ENOG4105EAD ABC transporter KHU1_2242 ENOG4105DRP amino acid AbC transporter KHU1_2243 ENOG41060CR KHU1_2245 ENOG4105C7H Helicase, RecD TraA family KHU1_2247 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KHU1_2248 ENOG4105C3J Cysteine desulfurase KHU1_2250 ENOG4105D1H recombination factor protein RarA KHU1_2251 ENOG4105CUZ uba thif-type nad fad binding protein KHU1_2252 ENOG4105C9M aspartyl-trna synthetase KHU1_2253 ENOG4105CUT histidyl-tRNA synthetase KHU1_2254 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHU1_2255 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) KHU1_2256 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KHU1_2259 ENOG41067VP Protein of unknown function (DUF1049) KHU1_2260 ENOG4105NCW Trka-c domain protein KHU1_2261 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KHU1_2263 ENOG4105CKP Polysaccharide Biosynthesis Protein KHU1_2264 ENOG4108QG2 Membrane KHU1_2265 ENOG4105NAP KHU1_2266 ENOG4105VIE preprotein translocase, subunit YajC KHU1_2267 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) KHU1_2268 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) KHU1_2269 ENOG41061AI Protein of unknown function (DUF2905) KHU1_2270 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) KHU1_2271 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) KHU1_2274 ENOG4106678 morphogenetic protein associated with SpoVID KHU1_2275 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) KHU1_2276 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KHU1_2277 ENOG4108IYU L-aspartate oxidase KHU1_2280 ENOG4105CQC Prephenate dehydratase KHU1_2282 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KHU1_2284 ENOG4105K46 50S ribosomal protein l27 KHU1_2285 ENOG4105X36 (ribosomal) protein KHU1_2286 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) KHU1_2289 ENOG4107QMS site-determining protein KHU1_2290 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) KHU1_2291 ENOG4105YHC Rod shape-determining protein MreD KHU1_2292 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KHU1_2293 ENOG4105DFF Rod shape-determining protein mreb KHU1_2294 ENOG4105W5Q DNA repair protein (RadC KHU1_2295 ENOG4108Z03 MAF-like protein KHU1_2297 ENOG4106A3R peptidase KHU1_2298 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KHU1_2299 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KHU1_2301 ENOG4106AR7 Spore coat protein KHU1_2302 ENOG41068KH stage VI sporulation protein D KHU1_2303 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase KHU1_2304 ENOG4105D52 delta-aminolevulinic acid dehydratase KHU1_2306 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) KHU1_2308 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) KHU1_2310 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) KHU1_2311 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) KHU1_2312 ENOG4108IUQ atp-dependent protease KHU1_2313 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) KHU1_2314 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KHU1_2316 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KHU1_2317 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) KHU1_2318 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KHU1_2320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KHU1_2321 ENOG4108ZP8 Acetolactate synthase small subunit KHU1_2322 ENOG4105C7K acetolactate synthase KHU1_2325 ENOG4105M59 Phosphodiesterase, mj0936 family KHU1_2326 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KHU1_2327 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) KHU1_2328 ENOG4108XJQ germination protein KHU1_2329 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KHU1_2330 ENOG41067TZ transcriptional regulator, MarR family KHU1_2331 ENOG4105PFC Transcriptional regulator KHU1_2333 ENOG4105E33 succinate dehydrogenase KHU1_2335 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KHU1_2337 ENOG4105CFH Aspartokinase KHU1_2338 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KHU1_2339 ENOG4105K63 Thioredoxin KHU1_2340 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KHU1_2341 ENOG4105C10 Electron transfer flavoprotein KHU1_2342 ENOG4105BZJ Electron transfer flavoprotein KHU1_2343 ENOG41060WC Enoyl-CoA hydratase KHU1_2344 ENOG4107Z3H Transcriptional regulator, TetR family KHU1_2345 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_2346 ENOG4108YV3 Protein of unknown function (DUF2711) KHU1_2348 ENOG4105C98 muts2 protein KHU1_2349 ENOG4105DCG PHP domain protein KHU1_2352 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) KHU1_2353 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KHU1_2354 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) KHU1_2355 ENOG4108RWN rrna methyltransferase KHU1_2356 ENOG41067MF small acid-soluble spore protein KHU1_2358 ENOG4105CQB FAD linked oxidase domain protein KHU1_2359 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KHU1_2361 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) KHU1_2362 ENOG4105DRS transport system, permease KHU1_2365 ENOG4108MDK Dehydrogenase KHU1_2367 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase KHU1_2368 ENOG4105EF1 ribulokinase KHU1_2370 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase KHU1_2371 ENOG4105CN9 Peptidase m42 family protein KHU1_2373 ENOG410696E Membrane KHU1_2374 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) KHU1_2375 ENOG4105VJV 50s ribosomal protein L35 KHU1_2376 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KHU1_2377 ENOG41067MG lrgb family KHU1_2379 ENOG4105DY9 regulatoR KHU1_2380 ENOG4108HRK Histidine kinase KHU1_2381 ENOG4105U0R haloacid dehalogenase-like hydrolase KHU1_2382 ENOG4105C22 threonyL-tRNA synthetase KHU1_2383 ENOG4108TDW sporulation protein YtxC KHU1_2388 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KHU1_2389 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KHU1_2390 ENOG4105KVH Transcriptional regulator KHU1_2391 ENOG4105F27 Major Facilitator KHU1_2392 ENOG4105CV8 reductase KHU1_2393 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KHU1_2395 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KHU1_2396 ENOG4105C2M dna polymerase I KHU1_2397 ENOG4105BZU Histidine kinase KHU1_2398 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHU1_2400 ENOG4108HMX isocitrate dehydrogenase (NADP) KHU1_2401 ENOG4105BZN citrate synthase KHU1_2403 ENOG4105G7B Protein of unknown function (DUF2992) KHU1_2405 ENOG4108REF Sporulation integral membrane protein ytvi KHU1_2406 ENOG4105FS0 cytoplasmic membrane protein KHU1_2407 ENOG4105CA9 Pyruvate kinase KHU1_2408 ENOG4105CTQ phosphohexokinase KHU1_2409 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) KHU1_2410 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) KHU1_2412 ENOG4105C6K Malic enzyme KHU1_2413 ENOG4105C0B DNA polymerase III (alpha subunit) KHU1_2414 ENOG4105VV2 KHU1_2416 ENOG4106EVM KHU1_2417 ENOG4105SFS phosphoesterase RecJ domain protein KHU1_2420 ENOG4105E8R UPF0173 metal-dependent hydrolase KHU1_2422 ENOG4105CH7 arginosuccinase KHU1_2423 ENOG4105CDH Citrulline--aspartate ligase KHU1_2424 ENOG4105EPU Molybdenum cofactor synthesis domain protein KHU1_2425 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KHU1_2427 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KHU1_2428 ENOG4105KBJ sporulation protein ytfj KHU1_2430 ENOG4105VK3 rdd domain containing protein KHU1_2431 ENOG4105D07 Signal peptide peptidase, SppA KHU1_2432 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KHU1_2433 ENOG4105EFZ amidohydrolase KHU1_2434 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KHU1_2436 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) KHU1_2441 ENOG4105U5Y Transcriptional regulator KHU1_2443 ENOG4105BZU Histidine kinase KHU1_2445 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) KHU1_2446 ENOG4105C26 Dehydrogenase KHU1_2451 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KHU1_2453 ENOG4108Z0Z intracellular protease Pfpi family KHU1_2457 ENOG4108NGU Transcriptional regulator KHU1_2460 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KHU1_2462 ENOG4105F1V Acetoin utilization protein KHU1_2463 ENOG4105W87 Cbs domain KHU1_2464 ENOG4105DGU Histone deacetylase KHU1_2465 ENOG4105ER2 Ompa motb domain protein KHU1_2466 ENOG4107R0U MotA TolQ exbB proton channel KHU1_2467 ENOG4105ETE Transcriptional regulator (LacI family KHU1_2468 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KHU1_2472 ENOG4105DFU Cell wall formation (By similarity) KHU1_2474 ENOG4108VDD TRNA binding domain protein KHU1_2477 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ KHU1_2480 ENOG4105C6K Malic enzyme KHU1_2481 ENOG4105C8F Beta-lactamase domain protein KHU1_2482 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) KHU1_2484 ENOG4108V15 phosphotransferase enzyme family KHU1_2487 ENOG4107F58 2'-5' rna ligase KHU1_2488 ENOG4105C6T cysteine synthase KHU1_2489 ENOG4107QSE Dipeptidase KHU1_2490 ENOG4105C7N Xanthine uracil vitamin C permease KHU1_2493 ENOG4105YW5 deoR family transcriptional regulator KHU1_2496 ENOG4105CBX hi0933 family KHU1_2497 ENOG4105C94 Transporter KHU1_2499 ENOG4105DQ6 Transposase KHU1_2503 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component KHU1_2504 ENOG4105I1K ABC transporter KHU1_2507 ENOG41085GJ domain protein KHU1_2508 ENOG4105C8T Leucyl-tRNA synthetase KHU1_2510 ENOG4105BZU Histidine kinase KHU1_2511 ENOG410605W Major Facilitator KHU1_2514 ENOG4105C19 ABC transporter KHU1_2515 ENOG4105EWM Histidine kinase KHU1_2517 ENOG4107R34 abc transporter permease protein KHU1_2518 ENOG4105C19 ABC transporter KHU1_2522 ENOG4105DVE abc transporter atp-binding protein KHU1_2523 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KHU1_2525 ENOG4105N5T Radical SAM Protein KHU1_2528 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KHU1_2530 ENOG4105E8V Alpha Beta Hydrolase Fold protein KHU1_2531 ENOG4108Z0R Transferase KHU1_2532 ENOG4105C85 amino acid KHU1_2533 ENOG4105CAQ asparagine synthetase KHU1_2534 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP KHU1_2535 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase KHU1_2538 ENOG4105D2X ABC transporter substrate-binding protein KHU1_2540 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KHU1_2543 ENOG4108RMU ferritin dps family protein KHU1_2545 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) KHU1_2546 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) KHU1_2547 ENOG4108V2W Carbonate dehydratase KHU1_2548 ENOG4105NRA 50s ribosomal protein l31 type b KHU1_2552 ENOG4105CC5 ABC transporter KHU1_2553 ENOG4105DTQ mandelate racemase muconate lactonizing KHU1_2554 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_2555 ENOG4108IPT Naphthoate synthase KHU1_2556 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KHU1_2557 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KHU1_2558 ENOG4105E4F Isochorismate synthase KHU1_2561 ENOG4105N67 Proton-coupled thiamine transporter YuaJ KHU1_2562 ENOG4105DZ6 Band 7 protein KHU1_2564 ENOG4106DF1 KHU1_2565 ENOG4108VNY MOSC domain protein KHU1_2566 ENOG4108JB8 alcohol dehydrogenase KHU1_2567 ENOG4105C26 Dehydrogenase KHU1_2568 ENOG4105TRT Transcriptional regulator KHU1_2571 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj KHU1_2572 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KHU1_2575 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KHU1_2577 ENOG4105EE0 oxidoreductase KHU1_2578 ENOG4108Z0Z intracellular protease Pfpi family KHU1_2579 ENOG4105C8Q Methyl-accepting chemotaxis KHU1_2580 ENOG4105C8Q Methyl-accepting chemotaxis KHU1_2581 ENOG4105C8Q Methyl-accepting chemotaxis KHU1_2582 ENOG4105C8Q Methyl-accepting chemotaxis KHU1_2585 ENOG4105EA8 2-Nitropropane dioxygenase KHU1_2586 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme KHU1_2588 ENOG4105C37 (CBS) domain KHU1_2591 ENOG4107PBV potassium channel KHU1_2592 ENOG4107PBV potassium channel KHU1_2595 ENOG4107QYV phosphohexose isomerase KHU1_2598 ENOG4105CHJ isochorismatase hydrolase KHU1_2600 ENOG4107QW4 alcohol dehydrogenase KHU1_2601 ENOG4105WG9 Conserved Protein KHU1_2603 ENOG4105CHM Aminotransferase KHU1_2604 ENOG4108ZB6 transcriptional regulator AsnC family KHU1_2605 ENOG4108MUZ hydrolase KHU1_2607 ENOG4105C87 Aminotransferase class I and II KHU1_2608 ENOG4108HGU Histidine kinase KHU1_2609 ENOG4105Y38 Kinase-associated protein B KHU1_2612 ENOG4105BZ4 penicillin-binding protein KHU1_2613 ENOG4105KIR Thiol-disulfide oxidoreductase dcc KHU1_2616 ENOG4108MRH transcriptional regulatory protein KHU1_2617 ENOG4105DIH basic membrane KHU1_2618 ENOG4108JQ9 ABC transporter KHU1_2619 ENOG4105UIB (ABC) transporter KHU1_2622 ENOG4105D65 subunit l KHU1_2623 ENOG4105HC0 Na H antiporter KHU1_2624 ENOG4108ZE9 Monovalent cation H antiporter subunit C KHU1_2625 ENOG4108JPZ Monovalent cation H antiporter subunit D KHU1_2626 ENOG4105SC1 monovalent cation H antiporter subunit E KHU1_2628 ENOG4105KJM monovalent cation h antiporter subunit g KHU1_2629 ENOG4105KA0 thioesterase Superfamily protein KHU1_2631 ENOG4105BZU Histidine kinase KHU1_2636 ENOG4105D58 Diguanylate phosphodiesterase KHU1_2637 ENOG4105DAP Nicotinate phosphoribosyltransferase KHU1_2642 ENOG4105C02 permease KHU1_2645 ENOG410904N short-chain dehydrogenase reductase KHU1_2652 ENOG4108K8K Transcriptional regulator KHU1_2653 ENOG4105DCF alanine dehydrogenase KHU1_2655 ENOG4105WQT MbtH domain protein KHU1_2656 ENOG4105CEY Amp-dependent synthetase and ligase KHU1_2657 ENOG4105WQI isochorismatase KHU1_2658 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase KHU1_2659 ENOG4105E4F Isochorismate synthase KHU1_2660 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KHU1_2661 ENOG4105NIV Esterase KHU1_2665 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) KHU1_2667 ENOG4105DQ6 Transposase KHU1_2669 ENOG41069ER domain protein KHU1_2671 ENOG4105CEP NADH dehydrogenase KHU1_2674 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) KHU1_2677 ENOG4105CJ1 ABC, transporter KHU1_2681 ENOG4105D9U N-acetyltransferase KHU1_2682 ENOG4108VHC Short-chain dehydrogenase reductase Sdr KHU1_2683 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KHU1_2684 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) KHU1_2686 ENOG4105ZKE UPF0349 protein KHU1_2689 ENOG41083MR nifu domain-containing protein KHU1_2690 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KHU1_2691 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) KHU1_2692 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) KHU1_2693 ENOG4105D6E homoserine dehydrogenase KHU1_2695 ENOG4108W5N phosphatidylglycerophosphatase a KHU1_2696 ENOG4105D4U had-superfamily hydrolase, subfamily iia KHU1_2698 ENOG4105MMD transcriptional regulator KHU1_2699 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) KHU1_2700 ENOG4105FAA peptidase M23 KHU1_2701 ENOG4108YTE sporulation protein YunB KHU1_2702 ENOG4107R8B 5'-nucleotidase KHU1_2704 ENOG4105I3N Conserved Protein KHU1_2706 ENOG4105CD3 dihydroorotase KHU1_2707 ENOG4105G9B Transcriptional regulator KHU1_2711 ENOG4105C5R Aminotransferase KHU1_2713 ENOG4108K8S endonuclease I KHU1_2714 ENOG4108IJ9 (ABC) transporter KHU1_2715 ENOG4105FDP GntR family transcriptional regulator KHU1_2716 ENOG4108KPW sugar kinase KHU1_2717 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component KHU1_2718 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component KHU1_2719 ENOG4105XN3 extracellular solute-binding protein family 1 KHU1_2720 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine KHU1_2726 ENOG4105PKS Excinuclease abc c subunit domain protein KHU1_2727 ENOG4107VFR oxidoreductase KHU1_2728 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KHU1_2730 ENOG41083Q9 chitosanase KHU1_2731 ENOG4105DIW FeS assembly protein SUFB KHU1_2732 ENOG4108UNV SUF system FeS assembly protein, NifU family KHU1_2733 ENOG4105C9B Cysteine desulfurase KHU1_2734 ENOG4105JRK feS assembly protein SufD KHU1_2735 ENOG4105C3K feS assembly ATPase SufC KHU1_2737 ENOG4105D01 (LipO)protein KHU1_2738 ENOG4108UMI ABC transporter, permease KHU1_2739 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KHU1_2744 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) KHU1_2745 ENOG41080E8 Transcriptional regulator, Spx MgsR family KHU1_2746 ENOG4105C1G acyl-Coa dehydrogenase KHU1_2747 ENOG4105CHU acetyl-coa acetyltransferase KHU1_2752 ENOG41067TZ transcriptional regulator, MarR family KHU1_2753 ENOG4105C0R drug resistance transporter emrb qaca subfamily KHU1_2754 ENOG4105C5Q Transcriptional regulator KHU1_2758 ENOG4105E0A ABC, transporter KHU1_2761 ENOG4105E1F short-chain dehydrogenase reductase KHU1_2762 ENOG4105HUF DNA protection during starvation protein KHU1_2763 ENOG4105C0H protease KHU1_2765 ENOG4105F3H Histidine kinase KHU1_2766 ENOG41067SE Tetr family transcriptional regulator KHU1_2767 ENOG4105C9Q fumarate hydratase class II KHU1_2772 ENOG4105WH1 Two component transcriptional regulator luxr family KHU1_2773 ENOG4105ENE Histidine kinase KHU1_2776 ENOG41087YS Phage shock protein A KHU1_2779 ENOG4108WBT adenosyltransferase KHU1_2780 ENOG4105E0A ABC, transporter KHU1_2781 ENOG4105EHG Permease protein KHU1_2782 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) KHU1_2783 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KHU1_2784 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein KHU1_2786 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHU1_2788 ENOG4106DF4 Sigma-70, region 4 KHU1_2789 ENOG4105F0F Oxalate decarboxylase KHU1_2791 ENOG4105E0A ABC, transporter KHU1_2792 ENOG4105EHG Permease protein KHU1_2795 ENOG4105D5Q Arginine ornithine antiporter KHU1_2797 ENOG4107K5X Membrane-bound metal-dependent hydrolase KHU1_2798 ENOG4107QZ2 Sulfatase KHU1_2799 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KHU1_2800 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KHU1_2801 ENOG4105E0C molybdate abc transporter KHU1_2802 ENOG4105WH1 Two component transcriptional regulator luxr family KHU1_2803 ENOG4105BZU Histidine kinase KHU1_2804 ENOG4105CJ1 ABC, transporter KHU1_2806 ENOG4108KYE ABC-2 type transporter KHU1_2809 ENOG4105EEQ Na H antiporter KHU1_2811 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KHU1_2812 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KHU1_2813 ENOG4105EEM helicase KHU1_2814 ENOG4105EN6 Membrane KHU1_2817 ENOG4107ZQN disulfide bond KHU1_2818 ENOG4105C59 p-type ATPase KHU1_2819 ENOG4105C59 p-type ATPase KHU1_2820 ENOG410681U heavy metal transport detoxification protein KHU1_2821 ENOG4105VPX protein, conserved in bacteria KHU1_2822 ENOG4105D9R oxidoreductase KHU1_2823 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KHU1_2826 ENOG4105DEN Luciferase family KHU1_2827 ENOG4105CDA abc transporter atp-binding protein KHU1_2832 ENOG4108XSB acetyltransferase, (GNAT) family KHU1_2833 ENOG4108KSA LysR family transcriptional regulator KHU1_2834 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KHU1_2835 ENOG41067XF inhibitor KHU1_2836 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) KHU1_2837 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KHU1_2839 ENOG4105XZU Preprotein translocase, subunit SecG KHU1_2843 ENOG4105KVH Transcriptional regulator KHU1_2848 ENOG4105DA5 (ABC) transporter KHU1_2849 ENOG4105R40 Glycine betaine carnitine choline KHU1_2850 ENOG4108HQR Glycine betaine KHU1_2851 ENOG4105E90 ABC transporter KHU1_2852 ENOG4108IJ8 ABC transporter KHU1_2853 ENOG4107HG4 Transcriptional regulator KHU1_2854 ENOG4105R40 Glycine betaine carnitine choline KHU1_2855 ENOG4108HQR Glycine betaine KHU1_2856 ENOG4105E90 ABC transporter KHU1_2857 ENOG4108IJ8 ABC transporter KHU1_2858 ENOG4107HG4 Transcriptional regulator KHU1_2859 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein KHU1_2861 ENOG4105T65 Membrane-associated protein KHU1_2862 ENOG4108W0I acetyltransferase KHU1_2865 ENOG4105FJR Lmbe family KHU1_2868 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KHU1_2869 ENOG4108IAJ Nad-dependent epimerase dehydratase KHU1_2870 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KHU1_2871 ENOG4107QQG Dehydrogenase KHU1_2872 ENOG4105IIU Aminopeptidase KHU1_2873 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) KHU1_2874 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KHU1_2875 ENOG4105CP7 Triose-phosphate isomerase KHU1_2876 ENOG4105BZA Phosphoglycerate kinase KHU1_2878 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KHU1_2881 ENOG4105CMD Transcriptional regulator, GntR family KHU1_2882 ENOG4105DEN Luciferase family KHU1_2884 ENOG4105GZI Transcriptional regulator KHU1_2885 ENOG4107RT3 EamA-like transporter family KHU1_2887 ENOG4106KNT transcriptional regulator KHU1_2888 ENOG4105CMG Carbohydrate kinase KHU1_2889 ENOG4105C6Z Gluconate KHU1_2891 ENOG4107QR9 Iron-sulfur cluster binding protein KHU1_2892 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KHU1_2893 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KHU1_2894 ENOG4105JXH GntR family transcriptional regulator KHU1_2895 ENOG4105DAA L-lactate KHU1_2896 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KHU1_2898 ENOG4108ZPC Polysaccharide pyruvyl transferase KHU1_2899 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KHU1_2900 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family KHU1_2901 ENOG4105D3Q Sugar transferase KHU1_2903 ENOG4105K64 Glycosyl transferase, family 2 KHU1_2905 ENOG4107QRS glycosyltransferase group 2 family protein KHU1_2906 ENOG41068W6 Capsular polysaccharide biosynthesis protein KHU1_2907 ENOG4108KMV Glycosyl transferase (Group 1 KHU1_2908 ENOG4105K64 Glycosyl transferase, family 2 KHU1_2909 ENOG4108PQP glycosyl transferase group 1 KHU1_2911 ENOG4108QV3 biosynthesis protein KHU1_2912 ENOG4105HTX biosynthesis protein KHU1_2914 ENOG4105EBR Carboxylesterase KHU1_2916 ENOG4105NAE bifunctional deaminase-reductase domain protein KHU1_2918 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 KHU1_2919 ENOG4105PY6 Phenolic acid decarboxylase KHU1_2926 ENOG4108HKT sucrose-6-phosphate hydrolase KHU1_2927 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) KHU1_2928 ENOG4105ETE Transcriptional regulator (LacI family KHU1_2929 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KHU1_2930 ENOG4108KAM Transcriptional regulator KHU1_2931 ENOG4105C7F AcnD-accessory protein PrpF KHU1_2933 ENOG4108URH decarboxylase KHU1_2934 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain KHU1_2935 ENOG4105CHH sulfate transporter KHU1_2936 ENOG4108V2W Carbonate dehydratase KHU1_2937 ENOG4105C5I Dehydrogenase KHU1_2938 ENOG4105GGE ribonuclease KHU1_2939 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KHU1_2940 ENOG4105KRI phosphocarrier protein (HPr KHU1_2941 ENOG4105CIE May be required for sporulation (By similarity) KHU1_2942 ENOG4105CHW UPF0052 protein KHU1_2943 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) KHU1_2944 ENOG4108Z4K mutator MutT protein KHU1_2945 ENOG4105C3M thioredoxin reductase KHU1_2948 ENOG4105BZU Histidine kinase KHU1_2949 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHU1_2950 ENOG4105BZ1 (ABC) transporter KHU1_2951 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase KHU1_2952 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) KHU1_2953 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase KHU1_2954 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) KHU1_2955 ENOG4105ECC imidazole-glycerol-phosphate dehydratase KHU1_2956 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KHU1_2957 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) KHU1_2958 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) KHU1_2960 ENOG4108S4C acetyltransferase KHU1_2961 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KHU1_2963 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) KHU1_2964 ENOG4105CE4 GlcNAc 6-P deacetylase KHU1_2965 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) KHU1_2966 ENOG4105FDP GntR family transcriptional regulator KHU1_2967 ENOG4105J7D transcriptional regulator KHU1_2968 ENOG41088CQ domain protein KHU1_2969 ENOG41086DT Membrane protein of unknown function KHU1_2970 ENOG41067S9 phage shock protein C, PspC KHU1_2971 ENOG4108PY7 KHU1_2974 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KHU1_2975 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KHU1_2978 ENOG4105MKU Transcriptional regulator KHU1_2989 ENOG4105CN1 protease KHU1_2990 ENOG4108M26 parallel beta-helix repeat protein KHU1_2991 ENOG4105CRP Part of the ABC transporter FtsEX involved in KHU1_2992 ENOG4105CAK Cell division ATP-binding protein ftsE KHU1_2995 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KHU1_2996 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KHU1_2997 ENOG4105MS2 ribosomal subunit Interface protein KHU1_3000 ENOG4105MQ3 flagellar protein FliS KHU1_3001 ENOG4107RT6 flagellar hook-associated KHU1_3002 ENOG4105I03 Flagellin KHU1_3003 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) KHU1_3004 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) KHU1_3006 ENOG4105DTJ flagellar hook-associated protein KHU1_3007 ENOG4105E1Q flagellar hook-associated protein KHU1_3010 ENOG4105RU3 KHU1_3011 ENOG41081UC Inherit from COG: Competence protein KHU1_3015 ENOG4105WH1 Two component transcriptional regulator luxr family KHU1_3016 ENOG4105BZU Histidine kinase KHU1_3017 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KHU1_3018 ENOG4108KGH TRANSCRIPTIONal KHU1_3019 ENOG4105ESV Glycosyl transferase, family 4 KHU1_3020 ENOG4107EF8 Glycosyl transferase (Group 1 KHU1_3023 ENOG4105QZI O-Antigen Polymerase KHU1_3024 ENOG4105C6Y Udp-glucose 6-dehydrogenase KHU1_3025 ENOG4107RA4 Glycosyl transferase (Group 1 KHU1_3026 ENOG4105PSV Polysaccharide Biosynthesis Protein KHU1_3027 ENOG4105D3Q Sugar transferase KHU1_3028 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase KHU1_3029 ENOG4105JFG SpoIID LytB domain protein KHU1_3032 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KHU1_3033 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KHU1_3034 ENOG4105EY8 ABC transporter KHU1_3036 ENOG4107SJB teichoic acid biosynthesis KHU1_3038 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase KHU1_3040 ENOG4107RZX Teichoic acid biosynthesis protein KHU1_3042 ENOG4105DG6 mannose-6-phosphate isomerase KHU1_3045 ENOG4108NHD germination protein KHU1_3046 ENOG4107R8N Glycosyl transferase, family 2 KHU1_3047 ENOG4105C54 Major Facilitator superfamily KHU1_3048 ENOG4108KGH TRANSCRIPTIONal KHU1_3049 ENOG4105J7I hydrolase KHU1_3050 ENOG4106UBQ KHU1_3051 ENOG4105K4H Nlp p60 protein KHU1_3052 ENOG4105PNM synthesis protein KHU1_3054 ENOG4105N98 Capsule biosynthesis protein capB KHU1_3055 ENOG4105E1K spore germination protein KHU1_3058 ENOG4105ETE Transcriptional regulator (LacI family KHU1_3059 ENOG4108RVA ribokinase KHU1_3060 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) KHU1_3061 ENOG4105C2J ABC transporter KHU1_3062 ENOG4105CNN ABC, transporter KHU1_3063 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KHU1_3065 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein KHU1_3066 ENOG4107FQX Alpha-acetolactate decarboxylase KHU1_3068 ENOG4107RSM transcriptional regulator KHU1_3071 ENOG4106UIA KHU1_3074 ENOG4107XC4 flavin reductase domain protein, FMN-binding KHU1_3075 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) KHU1_3077 ENOG4105CAH Chromate KHU1_3078 ENOG4105FGV Chromate KHU1_3079 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) KHU1_3080 ENOG4106YAD MORN repeat variant KHU1_3084 ENOG4108XI2 Domain of unknown function (DUF1963) KHU1_3085 ENOG4105C6Y Udp-glucose 6-dehydrogenase KHU1_3086 ENOG4108RB3 Capsular polysaccharide biosynthesis protein KHU1_3087 ENOG4107YJ4 chain length determinant protein KHU1_3088 ENOG4105HTX biosynthesis protein KHU1_3091 ENOG4105KBK Zinc finger, swim domain protein KHU1_3092 ENOG4105C0D helicase KHU1_3093 ENOG410667J hydrolase KHU1_3094 ENOG4105E98 transcriptional regulator DeoR family KHU1_3095 ENOG4105Z8H single-stranded DNA-binding protein KHU1_3098 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) KHU1_3099 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) KHU1_3101 ENOG4105CGA flagellar basal-body rod protein FlgG KHU1_3103 ENOG4105DFF Rod shape-determining protein mreb KHU1_3104 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KHU1_3105 ENOG4107MII Sugar-specific transcriptional regulator TrmB KHU1_3106 ENOG4105CZM Major Facilitator KHU1_3107 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease KHU1_3108 ENOG41080V3 Major Facilitator superfamily KHU1_3109 ENOG4105D3W isochorismatase KHU1_3111 ENOG4105BZU Histidine kinase KHU1_3113 ENOG4105CNI cell division protein FtsW KHU1_3114 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KHU1_3116 ENOG4105FRN stage II sporulation protein KHU1_3117 ENOG4107TCE N-acetyltransferase KHU1_3120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KHU1_3121 ENOG4106BRK KHU1_3122 ENOG4107T94 Endo-14-beta-xylanase KHU1_3123 ENOG4108Z40 Transcriptional regulator KHU1_3124 ENOG4105CQM Urea amidohydrolase subunit alpha KHU1_3125 ENOG4105KI2 Urea amidohydrolase subunit beta KHU1_3126 ENOG4108YZ9 Urea amidohydrolase subunit gamma KHU1_3130 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KHU1_3131 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KHU1_3132 ENOG4108TF4 von Willebrand factor, type A KHU1_3135 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KHU1_3137 ENOG4106778 Protein of unknown function (DUF1146) KHU1_3139 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) KHU1_3140 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) KHU1_3141 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) KHU1_3142 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) KHU1_3143 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) KHU1_3146 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) KHU1_3148 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) KHU1_3149 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) KHU1_3150 ENOG4108UIC UPF0340 protein KHU1_3151 ENOG4108YZG isomerase KHU1_3152 ENOG4107WAU Protein tyrosine phosphatase KHU1_3153 ENOG410815N Probably functions as a manganese efflux pump (By similarity) KHU1_3154 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KHU1_3156 ENOG4108ZXQ stage ii sporulation protein r KHU1_3159 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KHU1_3160 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KHU1_3161 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KHU1_3163 ENOG4107TT2 Auxin Efflux Carrier KHU1_3164 ENOG4105C6K Malic enzyme KHU1_3165 ENOG4107104 thymidine kinase KHU1_3166 ENOG41082DI 50s ribosomal protein l31 KHU1_3167 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KHU1_3168 ENOG4105CBT Fructose-1,6-bisphosphatase KHU1_3169 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KHU1_3171 ENOG4105D2N Aldolase KHU1_3172 ENOG410812K response regulator receiver protein KHU1_3174 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) KHU1_3176 ENOG4105DF6 Fe-S oxidoreductase KHU1_3178 ENOG4105E5J UV damage endonuclease KHU1_3180 ENOG4105BZ1 (ABC) transporter KHU1_3181 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KHU1_3184 ENOG4105R3A Nitrate reductase KHU1_3185 ENOG4108IUE nitrate reductase beta subunit KHU1_3189 ENOG4107V6Q Cyclic nucleotide-binding domain KHU1_3191 ENOG4105C75 arginyL-tRNA synthetase KHU1_3192 ENOG410684U Domain of unknown function (DUF1934) KHU1_3196 ENOG4107JM4 Tetratricopeptide repeat KHU1_3205 ENOG4105CYW agmatinase KHU1_3206 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KHU1_3207 ENOG4105BZ4 penicillin-binding protein KHU1_3209 ENOG4108XFG YwhD family KHU1_3210 ENOG4108Z4T Peptidase M50 KHU1_3211 ENOG41069HH 4-oxalocrotonate tautomerase KHU1_3212 ENOG41067TZ transcriptional regulator, MarR family KHU1_3213 ENOG4105CUB amino acid KHU1_3215 ENOG4105DCI Phosphohydrolase KHU1_3217 ENOG4108VCI transcription factor, rsfa family KHU1_3218 ENOG4105K7K Transcriptional regulator KHU1_3220 ENOG4105CJ1 ABC, transporter KHU1_3221 ENOG4108TU7 Inherit from COG: (ABC) transporter KHU1_3225 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) KHU1_3226 ENOG4105DUM transcriptional regulator, lysR family KHU1_3227 ENOG4105HMI Membrane KHU1_3228 ENOG4108IJ2 phosphate acetyltransferase KHU1_3229 ENOG4107JTW chlorite dismutase KHU1_3231 ENOG4105CHM Aminotransferase KHU1_3237 ENOG4105FCW Major Facilitator superfamily KHU1_3238 ENOG4105C2C drug resistance transporter, Bcr CflA KHU1_3241 ENOG4105C26 Dehydrogenase KHU1_3242 ENOG4105D82 Glutamate dehydrogenase KHU1_3244 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase KHU1_3245 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KHU1_3246 ENOG4105C1B dTDP-glucose 4-6-dehydratase KHU1_3247 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KHU1_3248 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG KHU1_3249 ENOG4107TY6 Acylneuraminate cytidylyltransferase KHU1_3251 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD KHU1_3252 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase KHU1_3259 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) KHU1_3260 ENOG4108RJ9 Glycosyl transferase, family 2 KHU1_3264 ENOG4105DWF phosphomethylpyrimidine kinase KHU1_3267 ENOG4105C5Y PTS System KHU1_3270 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin KHU1_3271 ENOG4105DEN Luciferase family KHU1_3272 ENOG4105DQ6 Transposase KHU1_3274 ENOG4108DBC nitroreductase KHU1_3276 ENOG4105I4A GCN5-related N-acetyltransferase KHU1_3280 ENOG4105BZ9 Cytochrome C oxidase, subunit I KHU1_3281 ENOG4105E2S oxidase) subunit II KHU1_3282 ENOG4107BMA Transglycosylase associated protein KHU1_3284 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) KHU1_3285 ENOG4105WH5 Teichoic acid glycosylation protein KHU1_3290 ENOG4107ZXU DSBA oxidoreductase KHU1_3291 ENOG4105DBE peroxidase KHU1_3292 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) KHU1_3293 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase KHU1_3294 ENOG4105CMU LysR family (Transcriptional regulator KHU1_3295 ENOG4105VAW lrga family KHU1_3296 ENOG41067MG lrgb family KHU1_3298 ENOG4105DR4 Methyltransferase KHU1_3300 ENOG4105CK1 PTS System KHU1_3301 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin KHU1_3302 ENOG4105X1N Glycosyl transferase family 8 KHU1_3304 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KHU1_3305 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) KHU1_3306 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KHU1_3307 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) KHU1_3308 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KHU1_3309 ENOG4105CM2 brancheD-chain amino acid aminotransferase KHU1_3310 ENOG4105F8D glycoside hydrolase family 4 KHU1_3311 ENOG4105VCP PTS System KHU1_3312 ENOG4105CK1 PTS System KHU1_3313 ENOG4105VZJ PTS System KHU1_3314 ENOG4105EMD TRANSCRIPTIONal KHU1_3317 ENOG4105DQ5 transport system permease protein KHU1_3318 ENOG4105EHG Permease protein KHU1_3320 ENOG41082YX Transcriptional regulator, arsr family KHU1_3321 ENOG4107R5R arsenical pump membrane protein KHU1_3322 ENOG4105VZJ PTS System KHU1_3323 ENOG4105VCP PTS System KHU1_3324 ENOG4105CK1 PTS System KHU1_3325 ENOG4105CS2 ec 3.2.1.21 KHU1_3326 ENOG4105EVU fructokinase KHU1_3327 ENOG4105DG6 mannose-6-phosphate isomerase KHU1_3329 ENOG4105CH6 catalase KHU1_3330 ENOG4107QHE Choloylglycine hydrolase KHU1_3331 ENOG4105ETS cytosine purines uracil thiamine allantoin KHU1_3332 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) KHU1_3333 ENOG4108JJ8 (ABC) transporter KHU1_3334 ENOG4108JJ9 ABC, transporter KHU1_3335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KHU1_3336 ENOG4105C4M (Ubiquinol oxidase) subunit I KHU1_3337 ENOG4105D2K citrate carrier protein KHU1_3338 ENOG4107BJW polysaccharide deacetylase KHU1_3341 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KHU1_3343 ENOG4105CMR udp-glucose 4-epimerase KHU1_3344 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KHU1_3347 ENOG4105DHI Methyltransferase KHU1_3352 ENOG4105CH6 catalase KHU1_3353 ENOG4105D4T Citrate transporter KHU1_3355 ENOG4105CID antiterminator KHU1_3356 ENOG4105DEU major facilitator superfamily KHU1_3357 ENOG4105C1J atp-dependent rna helicase KHU1_3366 ENOG4105CNA YD repeat protein KHU1_3367 ENOG4108NR7 pectate lyase KHU1_3369 ENOG4107YZX Universal stress protein KHU1_3378 ENOG4106Z5D Glycoside Hydrolase Family 43 KHU1_3380 ENOG4105C84 Histidine ammonia-lyase KHU1_3381 ENOG4105CGP Urocanate hydratase KHU1_3382 ENOG4105CI2 imidazolone-5-propionate hydrolase KHU1_3383 ENOG4107W25 arginase agmatinase formiminoglutamase KHU1_3385 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KHU1_3386 ENOG4105D9N nucleoside KHU1_3387 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) KHU1_3388 ENOG4107RHR regulatoR KHU1_3389 ENOG410667J hydrolase KHU1_3395 ENOG4108V5C ABC transporter KHU1_3402 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHU1_3407 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KHU1_3412 ENOG4105WZ4 isomerase KHU1_3413 ENOG4105F0H myo-inositol catabolism protein KHU1_3414 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) KHU1_3416 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KHU1_3418 ENOG4105EDK PfkB domain protein KHU1_3420 ENOG4105C26 Dehydrogenase KHU1_3423 ENOG4105CPC Aldo Keto reductase KHU1_3424 ENOG4107QNK )-transporter KHU1_3425 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) KHU1_3427 ENOG41061TZ Short-chain dehydrogenase reductase Sdr KHU1_3428 ENOG4108S01 response regulator KHU1_3429 ENOG4108ZGX Histidine kinase KHU1_3430 ENOG4105ECK Fatty Acid Desaturase KHU1_3431 ENOG4105ST3 Transcriptional regulator KHU1_3432 ENOG4105C26 Dehydrogenase KHU1_3433 ENOG4108ITS PQQ enzyme repeat KHU1_3435 ENOG4105WAB arsR family transcriptional regulator KHU1_3436 ENOG4105F27 Major Facilitator KHU1_3437 ENOG41085PJ rdd domain containing protein KHU1_3439 ENOG4105D3R alkyl hydroperoxide reductase KHU1_3440 ENOG4108JU3 Alkyl hydroperoxide reductase KHU1_3441 ENOG4107R3N Filamentation induced by cAMP protein fic KHU1_3442 ENOG4105C85 amino acid KHU1_3443 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 KHU1_3444 ENOG4108XHQ (2Fe-2S)-binding domain protein KHU1_3448 ENOG4105XRQ Xanthine dehydrogenase accessory factor KHU1_3451 ENOG4106H3A restriction KHU1_3453 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) KHU1_3456 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) KHU1_3457 ENOG4105CPC Aldo Keto reductase KHU1_3458 ENOG4105WQG acetyltransferase KHU1_3460 ENOG41066UZ arginase EC 3.5.3.1 KHU1_3461 ENOG4108IQI permease KHU1_3462 ENOG4105C8Y Acetylornithine aminotransferase KHU1_3464 ENOG41082BM Transcriptional regulator, arsr family KHU1_3465 ENOG4108JUB Transcriptional regulator KHU1_3467 ENOG4105C5H ABC transporter KHU1_3470 ENOG4105D06 uba thif-type nad fad binding protein KHU1_3471 ENOG4105GR3 Histidine kinase KHU1_3472 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHU1_3473 ENOG4105C0H protease KHU1_3474 ENOG4105Q2H domain protein KHU1_3477 ENOG4105BZU Histidine kinase KHU1_3478 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KHU1_3479 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis KHU1_3480 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KHU1_3481 ENOG4105CDU Replicative dna helicase KHU1_3484 ENOG4105EDW glycosyl transferase, family 39 KHU1_3487 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR KHU1_3488 ENOG4105CPK Glycosyl transferase (Group 1 KHU1_3492 ENOG4105BZR domain protein KHU1_3493 ENOG4108XMW Membrane KHU1_3495 ENOG4105KVH Transcriptional regulator KHU1_3496 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase KHU1_3498 ENOG4105DQ6 Transposase KHU1_3499 ENOG4108UZ3 Transporter KHU1_3500 ENOG4105EDQ levansucrase EC 2.4.1.10 KHU1_3501 ENOG4108HKT sucrose-6-phosphate hydrolase KHU1_3502 ENOG4107XBN GntR Family Transcriptional Regulator KHU1_3505 ENOG4107V2S Transcriptional regulator KHU1_3506 ENOG4108VP3 Lysine exporter protein (LysE YggA) KHU1_3508 ENOG4108TVJ Nitroreductase KHU1_3509 ENOG4105FS7 Transcriptional regulator KHU1_3511 ENOG4108U05 Transcriptional regulator KHU1_3512 ENOG41082BV acetyltransferase KHU1_3514 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase KHU1_3515 ENOG4105CMU LysR family (Transcriptional regulator KHU1_3516 ENOG4105DTD Dehydrogenase KHU1_3518 ENOG4107Y9U Membrane KHU1_3519 ENOG4105C7Z Conserved Protein KHU1_3520 ENOG4107FCW Abortive infection protein KHU1_3522 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KHU1_3524 ENOG4105CGK Exodeoxyribonuclease III KHU1_3525 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KHU1_3527 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) KHU1_3528 ENOG4108UUM single-stranded DNA-binding protein KHU1_3529 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) KHU1_3530 ENOG4105C3G gtp-binding protein KHU1_3531 ENOG4108J2R molybdopterin oxidoreductase KHU1_3532 ENOG4105VDK protein, conserved in bacteria KHU1_3535 ENOG4108ZDA Sporulation protein YyaC KHU1_3536 ENOG4105FA0 parb-like partition protein KHU1_3537 ENOG4107QJE Chromosome Partitioning Protein KHU1_3540 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) KHU1_3541 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KHU1_3544 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) KHU1_3546 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) KHU1_3547 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KHU1_3548 ENOG410848D S4 domain protein YaaA KHU1_3549 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) KHU1_3551 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHU1_3552 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KHU1_3554 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KHU1_3556 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) KHU1_3557 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) KHU1_3558 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) KHU1_3559 ENOG4105BZW Glycerate kinase KHU1_3560 ENOG4105ZMH deoxynucleoside kinase KHU1_3562 ENOG4105VRS hydrolase family 18 KHU1_3563 ENOG4105GTG Isochorismatase KHU1_3564 ENOG4108Z6B deaminase KHU1_3565 ENOG4105C6E dna polymerase iii KHU1_3566 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) KHU1_3567 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) KHU1_3569 ENOG41067KS pro-sigma K processing KHU1_3572 ENOG4105CDW Resistance protein KHU1_3573 ENOG4105CXN decarboxylase KHU1_3574 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) KHU1_3575 ENOG4105X0R protein from nitrogen regulatory protein P-II KHU1_3576 ENOG4105XVJ Protein of unknown function (DUF327) KHU1_3577 ENOG4105FA2 dna polymerase iii KHU1_3578 ENOG4105MA4 psp1 domain protein KHU1_3580 ENOG41060K3 Methyltransferase KHU1_3581 ENOG4105VC4 domain protein KHU1_3582 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KHU1_3583 ENOG4105KRN Transcriptional regulator, abrb family KHU1_3584 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KHU1_3585 ENOG4105F8V Hydrolase, tatD family KHU1_3586 ENOG41069ER domain protein KHU1_3588 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) KHU1_3589 ENOG4105XFA sporulation peptidase YabG KHU1_3590 ENOG4105W42 Veg protein KHU1_3591 ENOG4105XEW small acid-soluble spore protein KHU1_3592 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) KHU1_3593 ENOG4105DFT pur operon repressor KHU1_3594 ENOG4105KME endoribonuclease L-psp KHU1_3595 ENOG4105K4W Could be involved in septation (By similarity) KHU1_3596 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) KHU1_3597 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KHU1_3598 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) KHU1_3601 ENOG4108JA2 transcriptioN-repair coupling factor KHU1_3602 ENOG4108M14 stage v sporulation protein t KHU1_3604 ENOG4108IY2 MazG family KHU1_3605 ENOG41082I2 s4 domain protein KHU1_3606 ENOG4105VYY sporulation protein yabp KHU1_3609 ENOG41060GV RNA binding s1 domain protein KHU1_3613 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KHU1_3614 ENOG4108UGV hypoxanthine phosphoribosyltransferase KHU1_3615 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KHU1_3616 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) KHU1_3617 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) KHU1_3618 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase KHU1_3619 ENOG4105C6T cysteine synthase KHU1_3620 ENOG4105CRQ synthase (Component I) KHU1_3621 ENOG4105DDQ anthranilate synthase KHU1_3622 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 KHU1_3623 ENOG4105EEI dihydropteroate synthase KHU1_3624 ENOG4105KRF dihydroneopterin aldolase KHU1_3625 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KHU1_3627 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KHU1_3628 ENOG4105CRK lysyL-tRNA synthetase KHU1_3630 ENOG4108Z0C Uvrb UvrC protein KHU1_3631 ENOG41066A3 ATP guanido phosphotransferase KHU1_3633 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KHU1_3634 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) KHU1_3635 ENOG4105CTP PilT protein domain protein KHU1_3636 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) KHU1_3637 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) KHU1_3638 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) KHU1_3639 ENOG4105D7W serine acetyltransferase KHU1_3641 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) KHU1_3642 ENOG4105C2N RNA methyltransferase TrmH family group 3 KHU1_3643 ENOG4105M0M Tetracycline resistance protein KHU1_3647 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KHU1_3648 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) KHU1_3650 ENOG4108VZM 50s ribosomal protein L10 KHU1_3651 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) KHU1_3652 ENOG4107Y49 methyltransferase KHU1_3653 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KHU1_3654 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KHU1_3655 ENOG4105XPM ribosomal protein KHU1_3656 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) KHU1_3657 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) KHU1_3658 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) KHU1_3659 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) KHU1_3660 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KHU1_3661 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) KHU1_3662 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) KHU1_3663 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) KHU1_3664 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) KHU1_3665 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity KHU1_3666 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) KHU1_3667 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) KHU1_3668 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) KHU1_3669 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) KHU1_3670 ENOG41082SA 50s ribosomal protein l29 KHU1_3671 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal KHU1_3674 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits KHU1_3676 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) KHU1_3677 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KHU1_3678 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) KHU1_3679 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) KHU1_3680 ENOG4105VPB 50S ribosomal protein L30 KHU1_3681 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) KHU1_3682 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KHU1_3683 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) KHU1_3684 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KHU1_3685 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) KHU1_3687 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits KHU1_3688 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) KHU1_3689 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KHU1_3690 ENOG4108ZT0 50S ribosomal protein l17 KHU1_3691 ENOG4108JJB ABC transporter KHU1_3692 ENOG4108JJB ABC transporter KHU1_3693 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KHU1_3694 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KHU1_3695 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) KHU1_3696 ENOG4108UJD 30S ribosomal protein S9 KHU1_3697 ENOG4108I0C methyltransferase KHU1_3701 ENOG4105D1F ATP-binding protein KHU1_3704 ENOG4108NMV polysaccharide deacetylase