locus-tag class description SB45_00010 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) SB45_00020 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) SB45_00025 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) SB45_00030 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) SB45_00035 ENOG4105BZW Glycerate kinase SB45_00045 ENOG4105ZMH deoxynucleoside kinase SB45_00055 ENOG4105VRS hydrolase family 18 SB45_00060 ENOG4105GTG Isochorismatase SB45_00065 ENOG4108Z6B deaminase SB45_00070 ENOG4105C6E dna polymerase iii SB45_00075 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) SB45_00080 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) SB45_00090 ENOG41067KS pro-sigma K processing SB45_00120 ENOG4105CDW Resistance protein SB45_00125 ENOG4105CXN decarboxylase SB45_00130 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) SB45_00135 ENOG4105X0R protein from nitrogen regulatory protein P-II SB45_00140 ENOG4105XVJ Protein of unknown function (DUF327) SB45_00145 ENOG4105FA2 dna polymerase iii SB45_00150 ENOG4105MA4 psp1 domain protein SB45_00160 ENOG41060K3 Methyltransferase SB45_00165 ENOG4105VC4 domain protein SB45_00170 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) SB45_00175 ENOG4105KRN Transcriptional regulator, abrb family SB45_00180 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) SB45_00185 ENOG4105F8V Hydrolase, tatD family SB45_00190 ENOG41069ER domain protein SB45_00200 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) SB45_00205 ENOG4105XFA sporulation peptidase YabG SB45_00210 ENOG4105W42 Veg protein SB45_00215 ENOG4105XEW small acid-soluble spore protein SB45_00220 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) SB45_00225 ENOG4105DFT pur operon repressor SB45_00230 ENOG4105KME endoribonuclease L-psp SB45_00235 ENOG4105K4W Could be involved in septation (By similarity) SB45_00240 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) SB45_00245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase SB45_00250 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) SB45_00265 ENOG4108JA2 transcriptioN-repair coupling factor SB45_00270 ENOG4108M14 stage v sporulation protein t SB45_00280 ENOG4108IY2 MazG family SB45_00285 ENOG41082I2 s4 domain protein SB45_00290 ENOG4105VYY sporulation protein yabp SB45_00305 ENOG41060GV RNA binding s1 domain protein SB45_00335 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) SB45_00340 ENOG4108UGV hypoxanthine phosphoribosyltransferase SB45_00345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) SB45_00350 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) SB45_00355 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) SB45_00360 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase SB45_00365 ENOG4105C6T cysteine synthase SB45_00370 ENOG4105CRQ synthase (Component I) SB45_00375 ENOG4105DDQ anthranilate synthase SB45_00380 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 SB45_00385 ENOG4105EEI dihydropteroate synthase SB45_00390 ENOG4105KRF dihydroneopterin aldolase SB45_00395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase SB45_00405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) SB45_00410 ENOG4105CRK lysyL-tRNA synthetase SB45_00495 ENOG4108Z0C Uvrb UvrC protein SB45_00500 ENOG41066A3 ATP guanido phosphotransferase SB45_00510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) SB45_00515 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) SB45_00520 ENOG4105CTP PilT protein domain protein SB45_00525 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) SB45_00530 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) SB45_00535 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) SB45_00540 ENOG4105D7W serine acetyltransferase SB45_00550 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) SB45_00555 ENOG4105C2N RNA methyltransferase TrmH family group 3 SB45_00560 ENOG4105M0M Tetracycline resistance protein SB45_00580 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) SB45_00585 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) SB45_00595 ENOG4108VZM 50s ribosomal protein L10 SB45_00600 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) SB45_00605 ENOG4107Y49 methyltransferase SB45_00610 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SB45_00615 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SB45_00620 ENOG4105XPM ribosomal protein SB45_00625 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) SB45_00630 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) SB45_00635 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) SB45_00640 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) SB45_00645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase SB45_00650 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) SB45_00655 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) SB45_00660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) SB45_00665 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) SB45_00670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity SB45_00675 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) SB45_00680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) SB45_00685 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) SB45_00690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) SB45_00695 ENOG41082SA 50s ribosomal protein l29 SB45_00700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal SB45_00705 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) SB45_00715 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits SB45_00720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) SB45_00725 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) SB45_00730 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) SB45_00735 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) SB45_00740 ENOG4105VPB 50S ribosomal protein L30 SB45_00745 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) SB45_00750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) SB45_00755 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) SB45_00760 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) SB45_00765 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) SB45_00775 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits SB45_00780 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) SB45_00785 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SB45_00790 ENOG4108ZT0 50S ribosomal protein l17 SB45_00795 ENOG4108JJB ABC transporter SB45_00800 ENOG4108JJB ABC transporter SB45_00805 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) SB45_00810 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) SB45_00815 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) SB45_00820 ENOG4108UJD 30S ribosomal protein S9 SB45_00825 ENOG4108I0C methyltransferase SB45_00845 ENOG4105D1F ATP-binding protein SB45_00860 ENOG4108NMV polysaccharide deacetylase SB45_00960 ENOG4108JPW Aminotransferase SB45_00975 ENOG4105CHH sulfate transporter SB45_00985 ENOG4108SA1 esterase SB45_01005 ENOG410874W AraC family transcriptional regulator SB45_01010 ENOG4105EHZ conserved protein UCP016719 SB45_01015 ENOG4105D17 glycoside hydrolase, family 3 domain protein SB45_01030 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate SB45_01040 ENOG4105EWC Purine nucleoside phosphorylase SB45_01070 ENOG4105EMN RNA polymerase sigma factor SB45_01080 ENOG4105C8B TIGR00159 family SB45_01085 ENOG4107U5W ybbr family SB45_01090 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) SB45_01115 ENOG41067MG lrgb family SB45_01125 ENOG41061AU MarR family Transcriptional regulator SB45_01140 ENOG4105BZU Histidine kinase SB45_01145 ENOG4105WH1 Two component transcriptional regulator luxr family SB45_01150 ENOG4105CJ1 ABC, transporter SB45_01175 ENOG4106DDH Sporulation-specific SASP protein SB45_01190 ENOG4107QTZ amino acid SB45_01195 ENOG4107VXM glycerophosphoryl diester phosphodiesterase SB45_01200 ENOG4105CXY transporter SB45_01235 ENOG4107SCQ Iron-containing alcohol dehydrogenase SB45_01240 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR SB45_01245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase SB45_01250 ENOG4107ZTW SNARE associated Golgi SB45_01265 ENOG4105C72 UPF0176 protein SB45_01275 ENOG4105CM2 brancheD-chain amino acid aminotransferase SB45_01280 ENOG4108IQI permease SB45_01285 ENOG4108J5H Homocysteine s-methyltransferase SB45_01295 ENOG4105CSV Glutaminase SB45_01320 ENOG41076HS cation diffusion facilitator family transporter SB45_01325 ENOG4108TVJ Nitroreductase SB45_01330 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase SB45_01335 ENOG4108VGI doxx family SB45_01340 ENOG4105XXY Thioredoxin SB45_01355 ENOG4105DGI Alkaline phosphatase SB45_01360 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) SB45_01365 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) SB45_01370 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) SB45_01375 ENOG4107EPV Aminotransferase class V SB45_01380 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB45_01385 ENOG4105J7D transcriptional regulator SB45_01390 ENOG4107RB3 L-asparaginase SB45_01395 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold SB45_01400 ENOG41060AI SEC-C motif SB45_01405 ENOG4107SET aldo keto reductase SB45_01435 ENOG4105H9W Short-chain dehydrogenase reductase Sdr SB45_01445 ENOG4105DSE periplasmic solute binding protein SB45_01450 ENOG4105DIK (ABC) transporter SB45_01460 ENOG4105DEN Luciferase family SB45_01465 ENOG4108N0M stress protein SB45_01470 ENOG4106FN3 tellurium resistance protein SB45_01475 ENOG4106FN3 tellurium resistance protein SB45_01480 ENOG4107TS3 membrane protein, TerC SB45_01485 ENOG4108TTB tellurium resistance protein SB45_01495 ENOG41079KZ Major Facilitator Superfamily SB45_01500 ENOG4108IJ7 Glycine betaine SB45_01505 ENOG4107SQ8 Glycine betaine SB45_01535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) SB45_01565 ENOG4105EIG urea carboxylase-associated protein 1 SB45_01570 ENOG4107RA1 nh(3)-dependent nad( ) synthetase SB45_01580 ENOG4105I1F Resistance protein SB45_01585 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) SB45_01590 ENOG4105DJB Major Facilitator Superfamily SB45_01595 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) SB45_01600 ENOG4105I82 acetyl xylan esterase SB45_01605 ENOG410756H nucleotidyltransferase SB45_01615 ENOG4105C26 Dehydrogenase SB45_01620 ENOG4105CK7 Sodium proline symporter SB45_01625 ENOG4107YHD transcriptional regulator SB45_01630 ENOG4105CAY ferredoxin--nadp reductase SB45_01635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) SB45_01640 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit SB45_01645 ENOG4108IFG nitrite reductase, (NAD(P)H) SB45_01650 ENOG4105CKI cobalamin synthesis protein SB45_01655 ENOG4105E2A Dehydrogenase SB45_01660 ENOG4105HHM rdd domain containing protein SB45_01685 ENOG41080HJ 6-phospho 3-hexuloisomerase SB45_01690 ENOG4108VA3 3-hexulose-6-phosphate synthase SB45_01695 ENOG4105KVH Transcriptional regulator SB45_01700 ENOG4105CEY Amp-dependent synthetase and ligase SB45_01720 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) SB45_01735 ENOG4105CDA abc transporter atp-binding protein SB45_01740 ENOG4105DRP amino acid AbC transporter SB45_01750 ENOG4106P55 Transcriptional regulator SB45_01755 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase SB45_01760 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) SB45_01765 ENOG41069ZX SB45_01770 ENOG41069ZX SB45_01775 ENOG4105DUX Transporter SB45_01790 ENOG4105E1K spore germination protein SB45_01805 ENOG4105CPU Monooxygenase SB45_01810 ENOG4108XSB acetyltransferase, (GNAT) family SB45_01815 ENOG4105EAB amino acid AbC transporter SB45_01820 ENOG4108HW4 amino acid AbC transporter SB45_01830 ENOG4105CH2 amidohydrolase SB45_01835 ENOG4108PGP mmge prpd family protein SB45_01845 ENOG4107WD8 ABC transporter, permease SB45_01850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB45_01855 ENOG4105BZU Histidine kinase SB45_01870 ENOG4105CFH Aspartokinase SB45_01875 ENOG4105DHS permease protein SB45_01880 ENOG4105CM4 permease protein SB45_01885 ENOG4108IPW abc transporter atp-binding protein SB45_01900 ENOG4105R8C Transcriptional regulator SB45_01905 ENOG4108DBC nitroreductase SB45_01910 ENOG41067V3 Antibiotic biosynthesis monooxygenase SB45_01915 ENOG4105YVS arsR family transcriptional regulator SB45_01925 ENOG4108JPW Aminotransferase SB45_01930 ENOG4105C26 Dehydrogenase SB45_01940 ENOG4105H9W Short-chain dehydrogenase reductase Sdr SB45_01945 ENOG4105KTB nuclear export factor GLE1 SB45_01950 ENOG4108T5E Copper resistance protein SB45_01955 ENOG4108ZYE Transcriptional regulator SB45_01975 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase SB45_01990 ENOG4105E7W lamb ycsf family protein SB45_01995 ENOG4105C5A transporter SB45_02000 ENOG4105CFM UPF0317 protein SB45_02005 ENOG4105P4J Allophanate hydrolase, subunit 1 SB45_02015 ENOG4107258 Transcriptional regulator SB45_02020 ENOG4105XJB lipolytic protein G-D-S-L family SB45_02030 ENOG41061CK Antibiotic biosynthesis monooxygenase SB45_02035 ENOG4107RVG penicillin-binding protein SB45_02040 ENOG4107QM2 Aldo Keto reductase SB45_02045 ENOG4105ETD TRANSCRIPTIONal SB45_02055 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB45_02070 ENOG410606W general stress protein SB45_02080 ENOG4105VCH membrane SB45_02090 ENOG4105C9U ATP-dependent DNA helicase RecQ SB45_02105 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) SB45_02110 ENOG4107R8N Glycosyl transferase, family 2 SB45_02120 ENOG4105C0X amino acid SB45_02160 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) SB45_02175 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) SB45_02180 ENOG4105RXJ SB45_02185 ENOG4105KPY Small multidrug resistance protein SB45_02190 ENOG4105EU9 SB45_02195 ENOG4105QVS general stress protein SB45_02200 ENOG41082W1 Cupin 2, conserved barrel domain protein SB45_02215 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit SB45_02220 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism SB45_02225 ENOG4108MRH transcriptional regulatory protein SB45_02230 ENOG4107QJT sodium dicarboxylate symporter SB45_02235 ENOG4106F5Q Membrane SB45_02240 ENOG4105CJ1 ABC, transporter SB45_02255 ENOG4105FDT acyl-CoA dehydrogenase SB45_02270 ENOG4105SZ6 Thioredoxin SB45_02275 ENOG4105CPF Cell wall formation (By similarity) SB45_02280 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) SB45_02285 ENOG4105C1J atp-dependent rna helicase SB45_02290 ENOG410905X membrane-flanked domain protein SB45_02295 ENOG4105CKV Membrane SB45_02305 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) SB45_02310 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein SB45_02315 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) SB45_02325 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) SB45_02330 ENOG4107MMM Anti-sigma-factor antagonist SB45_02335 ENOG4105FUA antagonist SB45_02340 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase SB45_02345 ENOG4107SGM protein serine threonine phosphatase SB45_02350 ENOG4105WN5 stage II sporulation protein SB45_02355 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) SB45_02365 ENOG41064BQ Phosphatase SB45_02375 ENOG410906U SprT-like SB45_02415 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein SB45_02425 ENOG4105CSH Transporter SB45_02440 ENOG4105K56 Transcriptional regulator SB45_02450 ENOG4108ZMQ domain protein SB45_02460 ENOG4108Z40 Transcriptional regulator SB45_02465 ENOG4108RYK Nad-dependent epimerase dehydratase SB45_02470 ENOG4105VEQ Cold shock protein SB45_02475 ENOG4105XTG Pfam:DUF156 SB45_02480 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase SB45_02485 ENOG4105VFE sira family SB45_02490 ENOG4107TPS domain protein SB45_02495 ENOG4105VFE sira family SB45_02500 ENOG41087NI Sulfite exporter TauE/SafE SB45_02520 ENOG4105IRW patatin-like phospholipase family protein SB45_02530 ENOG4107RCH Diaminopropionate ammonia-lyase SB45_02535 ENOG4108WYP Transcriptional regulator SB45_02540 ENOG4105KME endoribonuclease L-psp SB45_02545 ENOG4105C44 Serine transporter SB45_02550 ENOG4105CH2 amidohydrolase SB45_02555 ENOG4108MCI Transcriptional regulator, ARAC family SB45_02560 ENOG4105CE7 Amidase, hydantoinase carbamoylase family SB45_02565 ENOG4107U9B transcriptional regulator SB45_02570 ENOG4105DXI Major Facilitator superfamily SB45_02575 ENOG41062IR nudix hydrolase SB45_02590 ENOG4105DNP FAD linked oxidase domain protein SB45_02600 ENOG4105PGM cation diffusion facilitator family transporter SB45_02605 ENOG4105H3G oxidoreductase SB45_02620 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SB45_02645 ENOG4105DQ4 alcohol dehydrogenase SB45_02650 ENOG4105VUF Transcriptional regulator SB45_02660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SB45_02675 ENOG4105EQ0 Major Facilitator superfamily SB45_02680 ENOG4108JGH Tetr family transcriptional regulator SB45_02695 ENOG4105E2A Dehydrogenase SB45_02700 ENOG4105PGS Spore coat protein SB45_02715 ENOG4105ENE Histidine kinase SB45_02720 ENOG4108VB1 regulatoR SB45_02725 ENOG4105EYF MMPL domain protein SB45_02745 ENOG4108JYZ YitT family SB45_02755 ENOG4105C2C drug resistance transporter, Bcr CflA SB45_02760 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) SB45_02780 ENOG41090E6 transcriptional regulator MERR family SB45_02795 ENOG4105F2W methyltransferase SB45_02800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SB45_02805 ENOG4105DRR Transcriptional regulator, GntR family SB45_02825 ENOG4105FQP Beta-lactamase SB45_02830 ENOG41090UD (LipO)protein SB45_02835 ENOG4108SUT Major Facilitator Superfamily SB45_02840 ENOG4108TZY GntR Family Transcriptional Regulator SB45_02845 ENOG4105JXH GntR family transcriptional regulator SB45_02850 ENOG4105DJ2 Major Facilitator Superfamily SB45_02870 ENOG4107QTZ amino acid SB45_02890 ENOG4107QNK )-transporter SB45_02925 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) SB45_02930 ENOG4105K8N protein family UPF0079, ATPase SB45_02935 ENOG41072GX Peptidase M22 Glycoprotease SB45_02940 ENOG410801F ribosomal-protein-alanine acetyltransferase SB45_02945 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SB45_02950 ENOG4105C5H ABC transporter SB45_02955 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) SB45_02960 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) SB45_02965 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) SB45_02970 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) SB45_02980 ENOG4108TYN CAAX amino terminal protease family protein SB45_02985 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) SB45_02990 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) SB45_02995 ENOG4105ESF Peptidoglycan binding domain protein SB45_03010 ENOG4105PGZ NB-ARC domain SB45_03015 ENOG4105CPQ Dehydrogenase SB45_03020 ENOG4105CT4 transporter SB45_03035 ENOG41087YS Phage shock protein A SB45_03040 ENOG4105DQX Zinc finger domain SB45_03045 ENOG4108WV1 Pfam:DUF477 SB45_03055 ENOG4105EXC Acyl-transferase SB45_03060 ENOG4108P49 AntiSigma factor SB45_03065 ENOG4105JVQ RNA Polymerase SB45_03095 ENOG4107STQ Multicopper oxidase SB45_03100 ENOG4105C85 amino acid SB45_03105 ENOG4105C7R Atpase associated with various cellular activities aaa_3 SB45_03120 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) SB45_03135 ENOG4105C7N Xanthine uracil vitamin C permease SB45_03155 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) SB45_03160 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit SB45_03165 ENOG4105C83 adenylosuccinate lyase SB45_03170 ENOG4105C8V SAICAR synthetase SB45_03175 ENOG4105VR9 phosphoribosylformylglycinamidine synthase SB45_03180 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I SB45_03185 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii SB45_03195 ENOG4105CXB phosphoribosylaminoimidazole synthetase SB45_03200 ENOG4108V3E phosphoribosylglycinamide formyltransferase SB45_03205 ENOG4105DC1 bifunctional purine biosynthesis protein purh SB45_03210 ENOG4105C12 Phosphoribosylglycinamide synthetase SB45_03225 ENOG4108R5T secreted protein SB45_03230 ENOG4105KGF protein, YerC YecD SB45_03235 ENOG4105CBC glutamate synthase SB45_03250 ENOG4105C4R Atp-dependent dna helicase SB45_03255 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) SB45_03265 ENOG4105CRN Aminoglycoside phosphotransferase SB45_03270 ENOG4105KT7 mgtC SapB transporter SB45_03275 ENOG4105CK7 Sodium proline symporter SB45_03280 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SB45_03285 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) SB45_03290 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SB45_03295 ENOG4108IG5 Transcriptional regulator SB45_03305 ENOG4105CBD Diacylglycerol kinase SB45_03310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SB45_03320 ENOG4105CJ1 ABC, transporter SB45_03355 ENOG4105CDY transcriptional regulatory protein SB45_03365 ENOG41075D4 Aminoglycoside 6-adenylyltransferase SB45_03380 ENOG4105WEF catalase SB45_03385 ENOG4105M18 -acetyltransferase SB45_03395 ENOG4105H67 Protein of unknown function (DUF421) SB45_03400 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) SB45_03405 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SB45_03420 ENOG4106I4J membrane SB45_03430 ENOG4108R1P SB45_03435 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SB45_03445 ENOG4105E0M Sulfatase SB45_03450 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase SB45_03460 ENOG41090R9 glycosyltransferase SB45_03465 ENOG4107R51 Glycosyl transferase, family 2 SB45_03470 ENOG41090R9 glycosyltransferase SB45_03475 ENOG4105EU0 Major facilitator Superfamily SB45_03480 ENOG4105CUB amino acid SB45_03485 ENOG4105C26 Dehydrogenase SB45_03490 ENOG4105FKZ Methyl-accepting chemotaxis SB45_03495 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB45_03500 ENOG4107TVC Glycosyl transferase, family 2 SB45_03505 ENOG4105C5H ABC transporter SB45_03510 ENOG4107SWG transcriptional regulator MERR family SB45_03515 ENOG4105DXB Major Facilitator superfamily SB45_03520 ENOG4105C5H ABC transporter SB45_03525 ENOG4105FDU atp-dependent rna helicase SB45_03535 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein SB45_03550 ENOG4108J20 pectate lyase SB45_03555 ENOG4107QPK )-transporter SB45_03580 ENOG4108VAC response regulator SB45_03590 ENOG4108Z6X (sortase) family SB45_03600 ENOG4108MRH transcriptional regulatory protein SB45_03625 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) SB45_03630 ENOG4108RPX mosc domain containing protein SB45_03640 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) SB45_03680 ENOG4105C5Y PTS System SB45_03685 ENOG4105CG3 alpha amylase, catalytic region SB45_03690 ENOG4107414 GntR family transcriptional regulator SB45_03695 ENOG4108RCM Nitroreductase SB45_03710 ENOG4105CGH 5'-nucleotidase SB45_03715 ENOG4107RKG DJ-1/PfpI family SB45_03720 ENOG4105ETE Transcriptional regulator (LacI family SB45_03725 ENOG4105E2X shikimate dehydrogenase SB45_03730 ENOG4105FF2 Type I DHQase SB45_03745 ENOG4105KJF protein tyrosine phosphatase SB45_03755 ENOG4107U9T Pfam:Ribonuclease_BN SB45_03760 ENOG4108ISG Major Facilitator SB45_03765 ENOG4105UPD Calcium Proton SB45_03775 ENOG4105D8X mechanosensitive ion channel SB45_03795 ENOG4106KE4 Dehydrogenase SB45_03805 ENOG4105D7N magnesium and cobalt transport protein CorA SB45_03815 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SB45_03835 ENOG4107RUY (E1 component), alpha subunit SB45_03845 ENOG4107QKR Dehydrogenase SB45_03855 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family SB45_03865 ENOG4105F8D glycoside hydrolase family 4 SB45_03870 ENOG4108Q3X Transcriptional regulator SB45_03875 ENOG4105CI1 PTS System SB45_03880 ENOG4105BZ1 (ABC) transporter SB45_03885 ENOG4105BZ1 (ABC) transporter SB45_03895 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase SB45_03900 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) SB45_03905 ENOG4105U3E Transcriptional regulator SB45_03910 ENOG4105DYS nad(p)h dehydrogenase (quinone) SB45_03915 ENOG4105H93 Acyltransferase family SB45_03930 ENOG4108YYS metal-dependent hydrolase (By similarity) SB45_03935 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB45_03940 ENOG410834F Transcriptional regulator SB45_03950 ENOG4105JAB phenazine biosynthesis protein, phzf family SB45_03955 ENOG4107Y03 Nitroreductase SB45_03965 ENOG4105ECP epimerase SB45_03970 ENOG410902V Modulates RecA activity (By similarity) SB45_03980 ENOG4105F27 Major Facilitator SB45_03990 ENOG4108TCS Glutamyl endopeptidase SB45_04010 ENOG4106AKJ SB45_04015 ENOG4105D74 hydrolase SB45_04020 ENOG4105CKK Glycosyl transferase, family 2 SB45_04025 ENOG4105EJV Membrane SB45_04030 ENOG41067AE Membrane-bound metal-dependent hydrolase SB45_04035 ENOG4105CEN a g-specific adenine glycosylase SB45_04040 ENOG4106BXE SB45_04045 ENOG4105CAN Short-chain dehydrogenase reductase Sdr SB45_04065 ENOG4105BZ1 (ABC) transporter SB45_04070 ENOG4107NBY Membrane SB45_04075 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SB45_04080 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SB45_04085 ENOG4105G5W regulator Fur family SB45_04090 ENOG4105TUA UPF0295 protein SB45_04195 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) SB45_04200 ENOG4105DNP FAD linked oxidase domain protein SB45_04210 ENOG4105DEF Extracellular solute-binding protein, family 5 SB45_04220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB45_04225 ENOG4105C3U ABC transporter SB45_04230 ENOG4108JQ7 (ABC) transporter SB45_04245 ENOG4105E2Y ABC, transporter SB45_04250 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein SB45_04255 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component SB45_04265 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) SB45_04270 ENOG4107D63 SB45_04275 ENOG4105VZ8 Transcriptional regulator SB45_04290 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) SB45_04300 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) SB45_04320 ENOG4105CYN Serine protein kinase SB45_04330 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes SB45_04335 ENOG4105CW7 secretion protein, HlyD family SB45_04340 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB45_04345 ENOG4105CS1 NAD(P)H quinone oxidoreductase SB45_04360 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family SB45_04365 ENOG4105CZV ABC transporter SB45_04370 ENOG4105CJ1 ABC, transporter SB45_04375 ENOG4108TU7 Inherit from COG: (ABC) transporter SB45_04380 ENOG4105VEQ Cold shock protein SB45_04390 ENOG4105BZU Histidine kinase SB45_04430 ENOG4108YBP pseudouridine synthase SB45_04440 ENOG41080XP Cbs domain SB45_04445 ENOG4107YBY Hydrolase SB45_04450 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase SB45_04455 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SB45_04460 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator SB45_04470 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) SB45_04475 ENOG4105C6V Glycerol-3-phosphate dehydrogenase SB45_04525 ENOG4105ED1 spovr family SB45_04530 ENOG4105G6Z alkaline phosphatase SB45_04545 ENOG4105BZN citrate synthase SB45_04550 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB45_04555 ENOG4105CUB amino acid SB45_04560 ENOG4105C8J )-transporter SB45_04570 ENOG4105J37 SB45_04575 ENOG4108AEY RNA polymerase sigma factor SB45_04580 ENOG4105F6E Acyl-transferase SB45_04585 ENOG4105C37 (CBS) domain SB45_04595 ENOG4105CHM Aminotransferase SB45_04600 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase SB45_04605 ENOG4105C37 (CBS) domain SB45_04615 ENOG4105WMR Protein CrcB homolog SB45_04620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SB45_04625 ENOG4105D64 Mechanosensitive ion channel SB45_04630 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) SB45_04635 ENOG4107VMI polysaccharide deacetylase SB45_04640 ENOG4105F0I Aminotransferase SB45_04645 ENOG4105W1N transcriptional regulator SB45_04650 ENOG4105IIP Membrane SB45_04660 ENOG4105BZ1 (ABC) transporter SB45_04665 ENOG4105BZ1 (ABC) transporter SB45_04685 ENOG410839P SB45_04695 ENOG4106MP8 UPF0754 membrane protein SB45_04700 ENOG4105WZB UPF0342 protein SB45_04705 ENOG4105F1N DNA alkylation repair SB45_04715 ENOG4105D4P Coproporphyrinogen iii oxidase SB45_04725 ENOG4107S91 Sodium hydrogen exchanger SB45_04730 ENOG4105NCW Trka-c domain protein SB45_04740 ENOG4105CGU Enoyl-CoA hydratase SB45_04750 ENOG4108IUX (ABC) transporter SB45_04755 ENOG4105RHA ABC transporter, permease SB45_04760 ENOG4107VRP DNA repair exonuclease SB45_04765 ENOG4106D4I domain protein SB45_04770 ENOG4105EQI Metal Dependent Phosphohydrolase SB45_04780 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) SB45_04830 ENOG4105NBU tryptophan transport protein SB45_04835 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) SB45_04840 ENOG4105K59 histidine triad (HIT) protein SB45_04870 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation SB45_04875 ENOG4105BZ4 penicillin-binding protein SB45_04880 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) SB45_04885 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) SB45_04890 ENOG4105C1Q protoporphyrinogen oxidase SB45_04900 ENOG4105ECB domain protein SB45_04915 ENOG4105DER m42 family SB45_04925 ENOG4108RQ5 Beta-lactamase domain-containing protein SB45_04930 ENOG4105DF9 Lipoate-protein, ligase SB45_04940 ENOG4105CEY Amp-dependent synthetase and ligase SB45_04950 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 SB45_04970 ENOG4107TB6 phosphoglycerate mutase SB45_04980 ENOG4107F3J Amp-dependent synthetase and ligase SB45_04985 ENOG4107ZYJ bioY protein SB45_04990 ENOG4106YBV Methyl-accepting chemotaxis SB45_05010 ENOG4105XVF Competence transcription factor SB45_05020 ENOG4108ZMX Domain of unknown function (DU1801) SB45_05030 ENOG4105X3H Excalibur domain protein SB45_05035 ENOG4105K8R UPF0145 protein SB45_05040 ENOG4105E1V na solute symporter SB45_05045 ENOG4106CAD Protein of unknown function (DUF3311) SB45_05050 ENOG41060YP SB45_05065 ENOG4107SCK Monooxygenase SB45_05070 ENOG4108INS Transcriptional regulator SB45_05075 ENOG4108KK1 membrane protein AbrB duplication SB45_05085 ENOG4108IG5 Transcriptional regulator SB45_05095 ENOG4108QY0 Membrane SB45_05100 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination SB45_05105 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation SB45_05115 ENOG4105EYH Exonuclease SB45_05160 ENOG4105ERH Fumarylacetoacetate hydrolase SB45_05180 ENOG4105CAQ asparagine synthetase SB45_05190 ENOG4105UQX Mate efflux family protein SB45_05195 ENOG4106HBX Transcriptional Regulator AraC Family SB45_05200 ENOG4105ETE Transcriptional regulator (LacI family SB45_05205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) SB45_05210 ENOG4105SF0 DinB family SB45_05215 ENOG4105MYW Pentapeptide repeat protein SB45_05220 ENOG4105MA6 gCN5-related N-acetyltransferase SB45_05230 ENOG4108VPT UPF0234 protein SB45_05235 ENOG4105QNR S1 RNA binding domain protein SB45_05240 ENOG4105DIH basic membrane SB45_05245 ENOG4105C8Q Methyl-accepting chemotaxis SB45_05250 ENOG4105EPR degv family SB45_05255 ENOG4107AYK membrAne SB45_05265 ENOG41073B9 SB45_05270 ENOG4108KP7 hydrolase SB45_05275 ENOG4108MXZ Esterase SB45_05280 ENOG4105VG1 fes assembly suf system protein SB45_05285 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) SB45_05290 ENOG4105IQ5 FAD linked oxidase domain protein SB45_05300 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase SB45_05310 ENOG4105CAS nag kinase SB45_05315 ENOG4105C8Y Acetylornithine aminotransferase SB45_05320 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain SB45_05330 ENOG4105DBV ornithine carbamoyltransferase SB45_05360 ENOG4107RMD Basic membrane lipoprotein SB45_05375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) SB45_05380 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) SB45_05390 ENOG4105C3U ABC transporter SB45_05395 ENOG4108JQ7 (ABC) transporter SB45_05410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB45_05430 ENOG4105C31 Tryptophanyl-tRNA synthetase SB45_05435 ENOG4108J59 Extracellular solute-binding protein, family 5 SB45_05440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SB45_05445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB45_05455 ENOG4108JQ7 (ABC) transporter SB45_05470 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) SB45_05475 ENOG4108ZCF integral membrane protein SB45_05480 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis SB45_05490 ENOG4105DPN Oligoendopeptidase f SB45_05500 ENOG4105T58 Dithiol-disulfide isomerase SB45_05505 ENOG4108Z18 K06886 hemoglobin SB45_05510 ENOG4105E4C Lytic transglycosylase catalytic SB45_05515 ENOG4105MIX Adenylate cyclase SB45_05530 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) SB45_05535 ENOG4105EMS pseudouridine synthase SB45_05540 ENOG4107S1Q Phosphatase SB45_05550 ENOG4105ETU transcriptional activator (TenA SB45_05555 ENOG4108VEU Thiamine monophosphate synthase SB45_05575 ENOG4105D06 uba thif-type nad fad binding protein SB45_05580 ENOG4105DWF phosphomethylpyrimidine kinase SB45_05585 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH SB45_05590 ENOG4107A88 SB45_05640 ENOG4105ENA helicase SB45_05660 ENOG4105CJ1 ABC, transporter SB45_05675 ENOG4108ZMI UPF0477 protein SB45_05685 ENOG4105C28 cystathionine SB45_05690 ENOG4105C28 cystathionine SB45_05705 ENOG4106BHF SB45_05715 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase SB45_05745 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase SB45_05750 ENOG4105CMR udp-glucose 4-epimerase SB45_05755 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) SB45_05760 ENOG4105CK1 PTS System SB45_05765 ENOG4105VCP PTS System SB45_05775 ENOG4105E98 transcriptional regulator DeoR family SB45_05795 ENOG4105KT7 mgtC SapB transporter SB45_05810 ENOG4108IEG Formate dehydrogenase Alpha subunit SB45_05820 ENOG4106A3M Cytochrome p-450 SB45_05825 ENOG41087PP glycosyltransferase MGT family SB45_05835 ENOG4105EXQ uroporphyrinogen iii synthase hem4 SB45_05840 ENOG4105C4B ABC transporter, permease SB45_05845 ENOG4108IXI (ABC) transporter SB45_05855 ENOG4105Q95 Cupin 2, conserved barrel domain protein SB45_05870 ENOG4105D2H Uronic isomerase SB45_05875 ENOG4105CT4 transporter SB45_05880 ENOG4107KJX Transcriptional regulator SB45_05890 ENOG4105CTX dehydratase SB45_05895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB45_05900 ENOG4105F3H Histidine kinase SB45_05920 ENOG4105BZU Histidine kinase SB45_05925 ENOG4105WH1 Two component transcriptional regulator luxr family SB45_05940 ENOG4108JJA ABC, transporter SB45_05950 ENOG4107TSN permease SB45_05970 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase SB45_05975 ENOG4105KWG Pfam:DUF1696 SB45_05980 ENOG4105K7W phage-related replication protein SB45_05985 ENOG410635T phage-like element pbsx protein SB45_06025 ENOG4108TFU terminase (Small subunit) SB45_06030 ENOG4105IG6 Phage terminase, large subunit SB45_06035 ENOG4108MDF Phage Portal Protein SB45_06060 ENOG41060SN SB45_06075 ENOG4105PQS phage protein SB45_06080 ENOG4105FR7 XkdM protein, phage-like element PBSX SB45_06085 ENOG4105MTC XkdN-like protein SB45_06090 ENOG4108FKH Transglycosylase SLT domain SB45_06090 ENOG4108FKH Transglycosylase SLT domain SB45_06090 ENOG4108FKH Transglycosylase SLT domain SB45_06095 ENOG4108WZM domain protein SB45_06100 ENOG4105X7F SB45_06110 ENOG4105MFU Protein of unknown function (DUF2634) SB45_06115 ENOG41066EA baseplate J family protein SB45_06120 ENOG410906S phage-like element pbsx protein xkdt SB45_06130 ENOG41068G1 SB45_06160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase SB45_06175 ENOG4105CJ3 phosphate transporter SB45_06180 ENOG4107GRR phosphate transport regulator SB45_06185 ENOG4107R7I amino acid SB45_06195 ENOG4105EDW glycosyl transferase, family 39 SB45_06200 ENOG4105CKK Glycosyl transferase, family 2 SB45_06205 ENOG4105C0H protease SB45_06215 ENOG4108ME1 Peptidase M55 D-aminopeptidase SB45_06220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SB45_06225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB45_06230 ENOG4105C3U ABC transporter SB45_06240 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A SB45_06245 ENOG4105DTQ mandelate racemase muconate lactonizing SB45_06250 ENOG4107SN7 NLP P60 protein SB45_06255 ENOG4108JQ7 (ABC) transporter SB45_06260 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) SB45_06265 ENOG4107TUM Amidinotransferase SB45_06270 ENOG4108S4H thioesterase Superfamily protein SB45_06275 ENOG4108428 Inherit from COG: -acetyltransferase SB45_06285 ENOG41080TC multidrug resistance protein SB45_06290 ENOG4105CIY formyltetrahydrofolate deformylase SB45_06295 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) SB45_06310 ENOG4105K56 Transcriptional regulator SB45_06315 ENOG4108ZHJ Organic hydroperoxide resistance protein SB45_06330 ENOG4107TVC Glycosyl transferase, family 2 SB45_06340 ENOG4105D8G Major Facilitator superfamily SB45_06345 ENOG4108Y4K DNA-binding transcriptional activator SB45_06350 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) SB45_06355 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SB45_06365 ENOG4108W7F transporter, permease SB45_06370 ENOG4108JJB ABC transporter SB45_06375 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein SB45_06380 ENOG4105VRS hydrolase family 18 SB45_06385 ENOG4105CJW magnesium transporter SB45_06390 ENOG4105V75 Transcriptional regulator SB45_06410 ENOG4105DQE DNA ligase SB45_06415 ENOG4105FDF Could be involved in DNA repair (By similarity) SB45_06425 ENOG4107T5V SNARE associated Golgi SB45_06430 ENOG4107TS3 membrane protein, TerC SB45_06435 ENOG4108WZW RNA polymerase sigma SB45_06445 ENOG410681C small acid-soluble spore protein SB45_06455 ENOG4105D0M Protease HtpX homolog SB45_06465 ENOG410900G Protein of unknown function (DUF421) SB45_06470 ENOG4108TGC Acyltransferase SB45_06475 ENOG4105BZU Histidine kinase SB45_06480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) SB45_06485 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) SB45_06495 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase SB45_06505 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate SB45_06510 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) SB45_06515 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) SB45_06520 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) SB45_06530 ENOG4105BZU Histidine kinase SB45_06535 ENOG41090MY MarR family Transcriptional regulator SB45_06540 ENOG4105ER2 Ompa motb domain protein SB45_06545 ENOG4105E14 MotA TolQ exbB proton channel SB45_06560 ENOG4108K88 Membrane SB45_06570 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) SB45_06575 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase SB45_06580 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) SB45_06585 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) SB45_06635 ENOG4105F0V Cell wall hydrolase SB45_06650 ENOG4105C59 p-type ATPase SB45_06655 ENOG4105DC7 peptidase M24 SB45_06665 ENOG4105CID antiterminator SB45_06675 ENOG4105KRI phosphocarrier protein (HPr SB45_06680 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) SB45_06690 ENOG4105F6S Spore photoproduct lyase SB45_06695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer SB45_06700 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase SB45_06715 ENOG4105K4I Scp-like extracellular SB45_06725 ENOG4105BZU Histidine kinase SB45_06730 ENOG4105CHM Aminotransferase SB45_06735 ENOG4107R88 Chemotaxis protein (CheV) SB45_06740 ENOG4105UIN SB45_06750 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein SB45_06760 ENOG4105K6S Short-chain dehydrogenase reductase Sdr SB45_06770 ENOG4105EPM Diguanylate phosphodiesterase SB45_06775 ENOG4107IN1 Protein of unknown function (DUF1797) SB45_06780 ENOG4108XRC Protein of unknown function (DUF458) SB45_06810 ENOG4105NQC Flavodoxin SB45_06830 ENOG4105D8X mechanosensitive ion channel SB45_06835 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SB45_06850 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) SB45_06855 ENOG4105D06 uba thif-type nad fad binding protein SB45_06860 ENOG4105CVM Molybdenum cofactor synthesis domain protein SB45_06865 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein SB45_06870 ENOG4108ZAF Molybdopterin SB45_06875 ENOG41067WU Molybdopterin converting factor (Subunit 1) SB45_06885 ENOG4107X8C Efflux transporter RND family MFP subunit SB45_06890 ENOG4105C19 ABC transporter SB45_06895 ENOG4107RBB ABC transporter, permease SB45_06900 ENOG4105E98 transcriptional regulator DeoR family SB45_06905 ENOG4105DE4 1-phosphofructokinase SB45_06910 ENOG4105DM4 PTS System SB45_06925 ENOG4105C5H ABC transporter SB45_06930 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) SB45_06955 ENOG4105BZU Histidine kinase SB45_06965 ENOG4107ZYR domain protein SB45_06970 ENOG4105CPN adenine deaminase SB45_06975 ENOG4105CN5 Metallo-Beta-Lactamase SB45_06980 ENOG4106148 UPF0356 protein SB45_06985 ENOG4108X4Q Hydrolase SB45_06990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SB45_07005 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SB45_07010 ENOG4105C0W non-ribosomal peptide synthetase SB45_07015 ENOG4107SQU synthase SB45_07020 ENOG4105C0W non-ribosomal peptide synthetase SB45_07025 ENOG4107SQU synthase SB45_07030 ENOG4107SQU synthase SB45_07035 ENOG4107SQU synthase SB45_07040 ENOG4105C0W non-ribosomal peptide synthetase SB45_07045 ENOG4105FQP Beta-lactamase SB45_07055 ENOG4105CPP Dehydrogenase, E1 component SB45_07060 ENOG4105C7S Dehydrogenase SB45_07065 ENOG4107QN2 dihydrolipoyl dehydrogenase SB45_07080 ENOG4105CXN decarboxylase SB45_07085 ENOG4105WBI UPF0223 protein SB45_07100 ENOG4105ECY inositol monophosphatase SB45_07110 ENOG4105D4Y metalloprotease SB45_07145 ENOG4105CI3 gtp-binding protein typa SB45_07150 ENOG4105QA2 SB45_07165 ENOG4108IAB Phoh family SB45_07175 ENOG4105CSV Glutaminase SB45_07185 ENOG4105CNI cell division protein FtsW SB45_07190 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) SB45_07200 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) SB45_07210 ENOG4105BZ9 Cytochrome C oxidase, subunit I SB45_07215 ENOG4105CCU oxidase (Subunit III) SB45_07220 ENOG41064X9 cytochrome C oxidase subunit IV SB45_07235 ENOG41080XQ Signal transduction protein with cbs domains SB45_07240 ENOG4106UY4 Inherit from COG: Scp-like extracellular SB45_07270 ENOG4106H78 methyltransferase SB45_07275 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) SB45_07280 ENOG4105H20 Sporulation integral membrane protein YlbJ SB45_07285 ENOG4105D78 K07001 NTE family protein SB45_07290 ENOG41063PX domain protein SB45_07295 ENOG4105CDE UPF0348 protein SB45_07300 ENOG4105KNH Nucleic acid-binding protein SB45_07325 ENOG4108V6E Cell division protein mraZ SB45_07330 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) SB45_07340 ENOG4105CJN penicillin-binding protein SB45_07345 ENOG4105CJN penicillin-binding protein SB45_07350 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) SB45_07355 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) SB45_07360 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) SB45_07365 ENOG4105CNI cell division protein FtsW SB45_07370 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) SB45_07375 ENOG4105D4A Cell wall formation (By similarity) SB45_07380 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) SB45_07385 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) SB45_07390 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) SB45_07400 ENOG4105FFI sigma-e processing peptidase spoiiga SB45_07405 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_07415 ENOG4105DKW ABC transporter SB45_07425 ENOG4105WR5 sporulation protein, YlmC YmxH family SB45_07430 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase SB45_07435 ENOG4105DFA alanine racemase domain protein SB45_07440 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) SB45_07445 ENOG41067XK integral membrane protein SB45_07450 ENOG4105DBK s4 domain protein SB45_07465 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) SB45_07475 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) SB45_07480 ENOG4105C34 Pseudouridine synthase SB45_07485 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) SB45_07495 ENOG4105CXT aspartate transcarbamylase SB45_07505 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain SB45_07510 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain SB45_07515 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) SB45_07520 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) SB45_07525 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) SB45_07530 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) SB45_07545 ENOG4107RIQ Sulfate adenylate transferase SB45_07555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) SB45_07560 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein SB45_07565 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein SB45_07570 ENOG4105F23 Fibronectin-binding protein SB45_07580 ENOG4105DSJ YicC domain protein SB45_07585 ENOG4105KC4 UPF0296 protein SB45_07590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) SB45_07600 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase SB45_07605 ENOG4105C25 Primosomal protein n' SB45_07610 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SB45_07615 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) SB45_07620 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B SB45_07625 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs SB45_07630 ENOG4108ZF3 Phosphatase SB45_07635 ENOG4105D9P serine threonine protein kinase SB45_07640 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) SB45_07645 ENOG4105DJV ribulose-phosphate 3-epimerase SB45_07650 ENOG4105FJ0 thiamine SB45_07660 ENOG4105VB9 50S ribosomal protein l28 SB45_07665 ENOG4108ZAA Alkaline-shock protein SB45_07670 ENOG4105DP4 dak2 domain fusion protein ylov SB45_07680 ENOG4105EJQ L-serine dehydratase SB45_07685 ENOG4105CB5 ATP-dependent DNA helicase recG SB45_07690 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) SB45_07695 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) SB45_07700 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SB45_07705 ENOG4105CHR reductase SB45_07710 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) SB45_07715 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) SB45_07720 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) SB45_07725 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) SB45_07735 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) SB45_07745 ENOG4105K5M 30s ribosomal protein S16 SB45_07750 ENOG4108BW8 UPF0109 protein SB45_07765 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) SB45_07770 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) SB45_07775 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) SB45_07780 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) SB45_07790 ENOG4105VM1 flagellar SB45_07795 ENOG4105CMV Succinyl-CoA synthetase subunit beta SB45_07800 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha SB45_07805 ENOG4105C79 DNA protecting protein DprA SB45_07810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) SB45_07815 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) SB45_07820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) SB45_07825 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) SB45_07830 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) SB45_07840 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) SB45_07845 ENOG4108ZC9 flagellar basal-body rod protein flgc SB45_07850 ENOG4105VQ0 flagellar hook-basal body complex protein fliE SB45_07855 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) SB45_07860 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SB45_07875 ENOG4106YF4 Flagellar biosynthesis chaperone SB45_07885 ENOG410696Y Flagellar hook-length control protein SB45_07890 ENOG410822I Flagellar hook capping protein SB45_07895 ENOG4108JQA flagellar SB45_07900 ENOG41068WV flagellar FlbD family protein SB45_07910 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SB45_07915 ENOG4105DD5 Flagellar motor switch protein SB45_07920 ENOG4107YTP response regulator receiver protein SB45_07930 ENOG4105CN7 Flagellar biosynthetic protein FliP SB45_07935 ENOG4105VS8 Flagellar biosynthetic protein fliq SB45_07940 ENOG4105D19 Role in flagellar biosynthesis (By similarity) SB45_07945 ENOG4105D00 flagellar biosynthetic protein flhB SB45_07950 ENOG4105D7B Flagellar biosynthesis protein flha SB45_07955 ENOG4105FZW flagellar biosynthesis regulator FlhF SB45_07965 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) SB45_07970 ENOG4105CBS Chea signal transduction histidine kinase SB45_07975 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis SB45_07985 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) SB45_07990 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_08000 ENOG4105CE9 30S ribosomal protein S2 SB45_08010 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) SB45_08015 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) SB45_08020 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) SB45_08025 ENOG4105KNE Phosphatidate cytidylyltransferase SB45_08035 ENOG4105DZP Membrane-associated zinc metalloprotease SB45_08040 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) SB45_08045 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) SB45_08050 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) SB45_08055 ENOG4105CHV Transcription elongation factor NusA SB45_08060 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination SB45_08065 ENOG4105VHM ribosomal protein SB45_08070 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) SB45_08075 ENOG4105W7A Protein of unknown function (DUF503) SB45_08080 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) SB45_08085 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) SB45_08090 ENOG4105DTN riboflavin biosynthesis protein ribF SB45_08095 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) SB45_08100 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) SB45_08110 ENOG4105C1V Peptidase, M16 SB45_08120 ENOG4105E35 Dipicolinate synthase subunit A SB45_08125 ENOG4108S0H Dipicolinic acid synthetase, b subunit SB45_08130 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) SB45_08140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SB45_08150 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit SB45_08160 ENOG4105CNU cell division protein FtsK SB45_08165 ENOG4105FDP GntR family transcriptional regulator SB45_08180 ENOG4105EYF MMPL domain protein SB45_08195 ENOG4108RKS Short-chain dehydrogenase reductase Sdr SB45_08200 ENOG4105XZV Protein of unknown function (DUF3243) SB45_08215 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase SB45_08220 ENOG4105CEV competence damage-inducible protein SB45_08225 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) SB45_08230 ENOG4108A04 Beta-lactamase SB45_08240 ENOG4105D48 metallophosphoesterase SB45_08245 ENOG4105MCT stage V sporulation protein S SB45_08250 ENOG4105CPQ Dehydrogenase SB45_08255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) SB45_08260 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SB45_08280 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) SB45_08285 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) SB45_08295 ENOG4108IMY Transcriptional regulator SB45_08380 ENOG410682Q Phage transcriptional regulator, ArpU SB45_08480 ENOG4108FKH Transglycosylase SLT domain SB45_08490 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj SB45_08500 ENOG41068G1 SB45_08520 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase SB45_08545 ENOG4108151 Beta-lactamase domain protein SB45_08550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SB45_08555 ENOG4108JA1 polyketide synthase SB45_08560 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SB45_08565 ENOG41062T2 Acyl carrier protein SB45_08570 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase SB45_08575 ENOG4108MGH Enoyl-CoA hydratase SB45_08580 ENOG4108KQ6 Enoyl-CoA hydratase SB45_08585 ENOG4105C0W non-ribosomal peptide synthetase SB45_08590 ENOG4107SQU synthase SB45_08600 ENOG4105C0W non-ribosomal peptide synthetase SB45_08610 ENOG4106A3M Cytochrome p-450 SB45_08615 ENOG4105WFK nuclease SB45_08620 ENOG4105XPP Protein of unknown function (DUF1275) SB45_08630 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SB45_08640 ENOG4105K7W phage-related replication protein SB45_08645 ENOG4108X3M OsmC Ohr family protein SB45_08670 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) SB45_08695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SB45_08700 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SB45_08705 ENOG4105U6W MutT NUDIX family protein SB45_08720 ENOG4106F1P AAA ATPase, central domain protein SB45_08725 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) SB45_08730 ENOG4105CXI aluminum resistance protein SB45_08735 ENOG4105KV4 Transcriptional regulator SB45_08740 ENOG4105C5F glutamine synthetase SB45_08750 ENOG4105CT4 transporter SB45_08755 ENOG4105DSG hydrolase family 43 SB45_08765 ENOG4105C93 Xylose Isomerase SB45_08770 ENOG4105CMG Carbohydrate kinase SB45_08775 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) SB45_08795 ENOG4105DQ4 alcohol dehydrogenase SB45_08825 ENOG4108M1A Chitin-binding protein SB45_08845 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) SB45_08850 ENOG4105K7W phage-related replication protein SB45_08870 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) SB45_08880 ENOG4108SVB resolvase SB45_08885 ENOG4105VPS UPF0291 protein SB45_08890 ENOG4105CV1 Transketolase (EC 2.2.1.1) SB45_08900 ENOG4105VXM UPF0154 protein SB45_08910 ENOG4107QIV Cytochrome c biogenesis protein SB45_08945 ENOG4108I0Z Aconitate hydratase SB45_08950 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SB45_08965 ENOG41067CD Small, acid-soluble spore protein Tlp SB45_08975 ENOG4105MI2 SB45_08980 ENOG4105W8X HesB YadR YfhF-family protein SB45_08985 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) SB45_08990 ENOG4105K4P CoA-binding domain protein SB45_08995 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SB45_09020 ENOG4105CPQ Dehydrogenase SB45_09025 ENOG4108UHU Aldolase SB45_09030 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) SB45_09035 ENOG4105DMW Dehydrogenase reductase SB45_09045 ENOG4108I5G Major Facilitator superfamily SB45_09060 ENOG4105FVX SB45_09100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SB45_09110 ENOG4107SYN Glycosyl hydrolases family 43 SB45_09135 ENOG4105DTD Dehydrogenase SB45_09140 ENOG4108IIH CoA-transferase subunit B SB45_09145 ENOG4105D6N CoA-transferase, subunit a SB45_09150 ENOG4105CY2 Citrate transporter SB45_09155 ENOG4106A3M Cytochrome p-450 SB45_09160 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) SB45_09165 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) SB45_09170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) SB45_09175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SB45_09180 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) SB45_09190 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SB45_09195 ENOG4107T5V SNARE associated Golgi SB45_09200 ENOG4107QX3 carboxylase SB45_09205 ENOG4105E39 Enoyl-CoA hydratase SB45_09210 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase SB45_09215 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit SB45_09220 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SB45_09225 ENOG4105CEY Amp-dependent synthetase and ligase SB45_09230 ENOG4105C1G acyl-Coa dehydrogenase SB45_09235 ENOG4105F32 YngK protein SB45_09240 ENOG4106U2H Protein of unknown function (DUF1360) SB45_09250 ENOG4105C0W non-ribosomal peptide synthetase SB45_09265 ENOG4105C0W non-ribosomal peptide synthetase SB45_09275 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family SB45_09280 ENOG4108N2V aldose 1-epimerase SB45_09285 ENOG4107QJQ Mate efflux family protein SB45_09310 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) SB45_09315 ENOG4108RWP Major Facilitator Superfamily protein SB45_09320 ENOG4105WAB arsR family transcriptional regulator SB45_09330 ENOG4108KSA LysR family transcriptional regulator SB45_09335 ENOG4105CB2 alcohol dehydrogenase SB45_09340 ENOG4105BZ8 glutamate synthase SB45_09345 ENOG4105CBC glutamate synthase SB45_09350 ENOG4105C5Q Transcriptional regulator SB45_09355 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) SB45_09380 ENOG4108UB7 SB45_09385 ENOG4105IE8 Alpha-ketoglutarate permease SB45_09390 ENOG4107U6E carbohydrate kinase FGGY SB45_09395 ENOG4108M3J Dehydrogenase SB45_09400 ENOG4108J2R molybdopterin oxidoreductase SB45_09420 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr SB45_09430 ENOG4108Z7R Chaperone CsaA SB45_09435 ENOG4105FTV AraC Family Transcriptional Regulator SB45_09445 ENOG4108W8B Beta-lactamase domain protein SB45_09455 ENOG4105KTU Transcriptional regulator, arsr family SB45_09465 ENOG4108SJC Membrane SB45_09490 ENOG41069ER domain protein SB45_09495 ENOG4105C9U ATP-dependent DNA helicase RecQ SB45_09500 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) SB45_09505 ENOG4105SCY DNAK suppressor SB45_09545 ENOG4105C26 Dehydrogenase SB45_09550 ENOG4105EWU Squalene--hopene cyclase SB45_09555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) SB45_09560 ENOG4105C8J )-transporter SB45_09565 ENOG4105C09 Bile acid SB45_09575 ENOG4105C7S Dehydrogenase SB45_09580 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 SB45_09585 ENOG4107T89 von Willebrand factor, type A SB45_09590 ENOG4105GMT ATPase associated with various cellular activities aaa_5 SB45_09600 ENOG4105K4H Nlp p60 protein SB45_09605 ENOG41087PP glycosyltransferase MGT family SB45_09615 ENOG4107QMU Mate efflux family protein SB45_09620 ENOG4106SCS STAS domain SB45_09640 ENOG4105FR1 rard protein SB45_09655 ENOG41090U3 tautomerase SB45_09675 ENOG4105FBA Phospholipase Carboxylesterase SB45_09690 ENOG4105E1V na solute symporter SB45_09700 ENOG4105CS2 ec 3.2.1.21 SB45_09705 ENOG4108S3Y transcriptional regulator SB45_09725 ENOG4108VXD carboxy-peptidase SB45_09730 ENOG4105D3A purine nucleoside phosphorylase DeoD-type SB45_09735 ENOG4106Z5R SB45_09740 ENOG410841Q phosphoesterase PA-phosphatase related protein SB45_09770 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein SB45_09775 ENOG4108TSC N-acetyltransferase SB45_09780 ENOG4107S4Y M20 DapE family protein YgeY SB45_09795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SB45_09800 ENOG4105FTQ Dna gyrase SB45_09930 ENOG4106ANW SMI1_KNR4 SB45_09935 ENOG4106BHF SB45_09960 ENOG4105E0X reductase SB45_09965 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) SB45_09975 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) SB45_09980 ENOG41090WU lipolytic protein G-D-S-L family SB45_09985 ENOG4108KF3 Electron transport protein SCO1 SenC SB45_09995 ENOG4105C7B Threonine dehydratase SB45_10005 ENOG4108UT2 hemolysin iii SB45_10015 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) SB45_10020 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) SB45_10030 ENOG4107YX5 Pfam:DUF548 SB45_10035 ENOG4108Y6J UPF0403 protein SB45_10040 ENOG4105C01 Dihydroxy-acid dehydratase SB45_10055 ENOG4108V06 Glutathione peroxidase SB45_10060 ENOG4105CVG Homoserine O-transsuccinylase SB45_10100 ENOG41081VK Ribonuclease SB45_10120 ENOG410890F Dynamin family SB45_10130 ENOG41065KQ synthase SB45_10165 ENOG4105C2W permease SB45_10170 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) SB45_10175 ENOG4105CTD carboxy-peptidase SB45_10180 ENOG4105DVT helicase SB45_10195 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) SB45_10200 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) SB45_10205 ENOG4108UKS UPF0398 protein SB45_10210 ENOG4107X2U Inherit from COG: Exonuclease-like protein SB45_10215 ENOG4108I5C dEAD DEAH box helicase SB45_10260 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) SB45_10265 ENOG4105BZ4 penicillin-binding protein SB45_10275 ENOG4105CSM endonuclease III SB45_10285 ENOG4105C5S asparaginyl-tRNA synthetase SB45_10290 ENOG4105CHM Aminotransferase SB45_10300 ENOG4105DVT helicase SB45_10305 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) SB45_10315 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) SB45_10325 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate SB45_10330 ENOG4105CPK Glycosyl transferase (Group 1 SB45_10335 ENOG4105FJR Lmbe family SB45_10340 ENOG4108Z5K methylglyoxal synthase SB45_10345 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) SB45_10350 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase SB45_10355 ENOG4108JYZ YitT family SB45_10360 ENOG4105F0F Oxalate decarboxylase SB45_10380 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) SB45_10400 ENOG41068YB TPR repeat-containing protein SB45_10405 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase SB45_10415 ENOG4105CIH Imidazole acetol-phosphate transaminase SB45_10425 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) SB45_10430 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase SB45_10435 ENOG4105DK0 Indole-3-glycerol phosphate synthase SB45_10445 ENOG4105CRQ synthase (Component I) SB45_10450 ENOG4105KHN chorismate mutase SB45_10460 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase SB45_10465 ENOG4105BZU Histidine kinase SB45_10470 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) SB45_10475 ENOG4105EAH synthase SB45_10480 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) SB45_10485 ENOG4105XXQ heptaprenyl diphosphate synthase component I SB45_10490 ENOG4105WP2 Tryptophan RNA-binding attenuator protein SB45_10495 ENOG4105EUJ GTP cyclohydrolase i SB45_10500 ENOG4105K70 DNA-binding protein SB45_10505 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) SB45_10520 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase SB45_10525 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) SB45_10540 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) SB45_10545 ENOG4105CAT Cytidine monophosphate kinase SB45_10555 ENOG4105MSI germination protein ypeb SB45_10565 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) SB45_10570 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase SB45_10585 ENOG4107RGJ metallophosphoesterase SB45_10600 ENOG4105I7S Abortive infection protein SB45_10605 ENOG4105C9U ATP-dependent DNA helicase RecQ SB45_10610 ENOG4105T7X SB45_10620 ENOG4108SAX Membrane SB45_10625 ENOG4108JQ1 Dehydrogenase SB45_10640 ENOG4105BZU Histidine kinase SB45_10645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB45_10650 ENOG4105CRE cytochrome C SB45_10655 ENOG4107TWT Cytochrome c biogenesis protein SB45_10665 ENOG4105FE9 pseudouridine synthase SB45_10675 ENOG4108JIC nucleoside recognition domain protein SB45_10680 ENOG4105DZ1 carboxypeptidase SB45_10690 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) SB45_10695 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) SB45_10710 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) SB45_10715 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) SB45_10720 ENOG4108R6K riboflavin synthase, subunit alpha SB45_10745 ENOG4107ZE5 PPIases accelerate the folding of proteins SB45_10750 ENOG4105PTM secreted protein SB45_10755 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) SB45_10765 ENOG4105G6R Stage v sporulation protein ae SB45_10775 ENOG4105CZ3 stage V sporulation protein ad SB45_10780 ENOG41090VF Stage v sporulation protein ac SB45_10795 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_10800 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) SB45_10805 ENOG41082AN stage II sporulation protein SB45_10810 ENOG4105DZ1 carboxypeptidase SB45_10815 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) SB45_10820 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) SB45_10825 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) SB45_10835 ENOG4105I3K Ferric uptake regulator, Fur family SB45_10840 ENOG4105MZ9 stage II sporulation protein m SB45_10860 ENOG4105DFD Na H antiporter SB45_10865 ENOG4108IJ0 Aspartate ammonia-lyase SB45_10870 ENOG4105HDK L-asparaginase SB45_10875 ENOG4108IMY Transcriptional regulator SB45_10885 ENOG4108YZ4 nudix hydrolase SB45_10895 ENOG4105CPC Aldo Keto reductase SB45_10915 ENOG4106HZJ SB45_10920 ENOG4105RHY Pfam:UPF0157 SB45_10925 ENOG4105KAC Antibiotic biosynthesis monooxygenase SB45_10930 ENOG4108XET gCN5-related N-acetyltransferase SB45_10935 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SB45_10950 ENOG4105C02 permease SB45_10955 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase SB45_10960 ENOG4105CS9 pantothenic acid kinase SB45_10970 ENOG4108IXY short-chain dehydrogenase reductase SB45_10975 ENOG41069FQ Metallo-beta-lactamase superfamily SB45_10980 ENOG4105II7 pyrroline-5-carboxylate reductase SB45_10985 ENOG4108KQ6 Enoyl-CoA hydratase SB45_10990 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase SB45_10995 ENOG4106A3M Cytochrome p-450 SB45_11010 ENOG4105C0W non-ribosomal peptide synthetase SB45_11015 ENOG4105C0W non-ribosomal peptide synthetase SB45_11025 ENOG4105C0W non-ribosomal peptide synthetase SB45_11035 ENOG4105CHR reductase SB45_11040 ENOG4105CEY Amp-dependent synthetase and ligase SB45_11055 ENOG4107QKG PfaD family SB45_11060 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) SB45_11065 ENOG4108K70 Transcriptional regulator SB45_11075 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase SB45_11085 ENOG410861F 50S ribosomal protein L33 SB45_11090 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) SB45_11095 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase SB45_11100 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) SB45_11105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SB45_11115 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) SB45_11120 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SB45_11125 ENOG4108HNZ carboxyl transferase SB45_11130 ENOG4108ZVT methylmalonyl-coA epimerase SB45_11135 ENOG4108VZI ErfK ybiS ycfS ynhG family protein SB45_11140 ENOG4108QEG Membrane SB45_11145 ENOG4105CDA abc transporter atp-binding protein SB45_11150 ENOG4105E5Q amino acid AbC transporter SB45_11155 ENOG4108HW3 (ABC) transporter SB45_11160 ENOG4108Y6J UPF0403 protein SB45_11165 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) SB45_11170 ENOG4105C7S Dehydrogenase SB45_11175 ENOG4105CPP Dehydrogenase, E1 component SB45_11190 ENOG4105CKM Branched-chain carboxylic acid kinase SB45_11195 ENOG4107RDP Dehydrogenase SB45_11205 ENOG4108JUB Transcriptional regulator SB45_11210 ENOG4106CCJ Protein of unknown function (DUF2627) SB45_11215 ENOG4105CR4 methylisocitrate lyase SB45_11220 ENOG4105DXD 2-methylcitrate dehydratase SB45_11230 ENOG4105C1G acyl-Coa dehydrogenase SB45_11235 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SB45_11245 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SB45_11250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SB45_11275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase SB45_11290 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) SB45_11295 ENOG4107QQR Sporulation SB45_11300 ENOG4105S1Z Stage IV sporulation protein B SB45_11305 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) SB45_11310 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) SB45_11315 ENOG4105DX0 Hemolysin A SB45_11320 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) SB45_11325 ENOG4105CTB Polyprenyl synthetase SB45_11330 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) SB45_11335 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) SB45_11340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) SB45_11345 ENOG4105M7K Involved in the transcription termination process (By similarity) SB45_11350 ENOG4108ZSR alkaline shock protein SB45_11355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SB45_11375 ENOG410644B Stage III sporulation protein af SB45_11385 ENOG4105KQ4 Stage iii sporulation protein ad SB45_11390 ENOG4108CQH stage III sporulation protein AC SB45_11395 ENOG4105KR5 Stage iii sporulation protein SB45_11400 ENOG4105CD2 stage iii sporulation protein aa SB45_11410 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) SB45_11415 ENOG4105DC7 peptidase M24 SB45_11425 ENOG4105CBJ Metal-dependent enzyme SB45_11445 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) SB45_11450 ENOG4105WZW rhodanese family SB45_11455 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor SB45_11465 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) SB45_11470 ENOG4105C0D helicase SB45_11485 ENOG4108IMY Transcriptional regulator SB45_11495 ENOG4105VFR signal peptidase SB45_11555 ENOG4105C37 (CBS) domain SB45_11580 ENOG4105C5X domain protein SB45_11620 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase SB45_11630 ENOG41068DG YceG-like family SB45_11635 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SB45_11640 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SB45_11645 ENOG4105E2Z phosphate ABC transporter (Permease SB45_11650 ENOG4105C8U phosphate abc transporter SB45_11655 ENOG4105CVA phosphate SB45_11660 ENOG4107RF6 penicillin-binding protein SB45_11670 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) SB45_11675 ENOG4105SXS Protein of unknown function (DUF456) SB45_11690 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) SB45_11695 ENOG41063Y9 SB45_11700 ENOG4108U5J '-nucleotidase SB45_11705 ENOG4105N80 Ferric uptake regulator, Fur family SB45_11710 ENOG4108JYZ YitT family SB45_11715 ENOG41069ZM Protein of unknown function (DUF2624) SB45_11720 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) SB45_11735 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) SB45_11740 ENOG4105EGD dinuclear metal center protein, YbgI family SB45_11755 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_11760 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) SB45_11765 ENOG4108UPT UPF0178 protein SB45_11770 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) SB45_11780 ENOG4105C38 Glycyl-tRNA synthetase beta subunit SB45_11785 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit SB45_11790 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) SB45_11795 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) SB45_11800 ENOG4105KG3 cytidine deaminase SB45_11805 ENOG4107YR5 Diacylglycerol kinase SB45_11810 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) SB45_11815 ENOG4105CTJ Metal Dependent Phosphohydrolase SB45_11820 ENOG4105C9A Phoh family SB45_11825 ENOG4105EI1 sporulation protein yqfd SB45_11830 ENOG41068P3 sporulation protein YqfC SB45_11840 ENOG4105DI5 UPF0365 protein SB45_11845 ENOG4105F7J membrane-bound serine protease SB45_11850 ENOG4105KTH gatB Yqey SB45_11865 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SB45_11870 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) SB45_11875 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) SB45_11880 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) SB45_11885 ENOG4105CFG Acts as a chaperone (By similarity) SB45_11890 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ SB45_11895 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) SB45_11900 ENOG4105CSA Coproporphyrinogen iii oxidase SB45_11905 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) SB45_11915 ENOG4108ZRV stage ii sporulation protein p SB45_11920 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) SB45_11925 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) SB45_11930 ENOG4105TQK DNA polymerase iii, delta' subunit SB45_11940 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 SB45_11945 ENOG4108UK2 deaminase SB45_11950 ENOG4105KQC Competence protein SB45_11960 ENOG4108D32 Methyltransferase SB45_11970 ENOG4108WF2 Metal Dependent Phosphohydrolase SB45_11975 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) SB45_11980 ENOG410812S Rna-binding protein SB45_11985 ENOG4105E2X shikimate dehydrogenase SB45_11990 ENOG4105CQW ribosome biogenesis GTPase YqeH SB45_11995 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase SB45_12015 ENOG41080BT SNARE associated Golgi SB45_12025 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_12040 ENOG41086D8 Transcriptional regulator SB45_12045 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) SB45_12055 ENOG4108J8C transporter major facilitator family protein SB45_12060 ENOG4108U7W acetyltransferase SB45_12075 ENOG4108HCJ Hydrolase SB45_12080 ENOG4108HCJ Hydrolase SB45_12090 ENOG4105DG6 mannose-6-phosphate isomerase SB45_12095 ENOG4105DM4 PTS System SB45_12110 ENOG4108Z66 YbaK ebsC protein SB45_12115 ENOG4107RSM transcriptional regulator SB45_12120 ENOG4105D94 Major Facilitator Superfamily SB45_12125 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SB45_12130 ENOG41082JN Transcriptional regulator SB45_12145 ENOG4105TMB Formate nitrite transporter SB45_12150 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) SB45_12155 ENOG4108JB9 formate dehydrogenase SB45_12170 ENOG4105C28 cystathionine SB45_12200 ENOG4107XRG penicillin-binding protein SB45_12205 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) SB45_12215 ENOG4105CFP Peptidase U32 SB45_12220 ENOG4105XYU peptidase (U32 family) SB45_12225 ENOG4108VQJ O-methyltransferase SB45_12230 ENOG4105HHA aminodeoxychorismate lyase SB45_12240 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) SB45_12245 ENOG4105VBH UPF0297 protein SB45_12250 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) SB45_12255 ENOG4105C02 permease SB45_12260 ENOG4105CDA abc transporter atp-binding protein SB45_12265 ENOG4105CT1 (ABC) transporter SB45_12270 ENOG4105EAD ABC transporter SB45_12275 ENOG4105DRP amino acid AbC transporter SB45_12280 ENOG41060CR SB45_12290 ENOG4105C7H Helicase, RecD TraA family SB45_12300 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) SB45_12305 ENOG4105C3J Cysteine desulfurase SB45_12315 ENOG4105D1H recombination factor protein RarA SB45_12320 ENOG4105CUZ uba thif-type nad fad binding protein SB45_12325 ENOG4105C9M aspartyl-trna synthetase SB45_12330 ENOG4105CUT histidyl-tRNA synthetase SB45_12335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SB45_12340 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) SB45_12345 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) SB45_12355 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) SB45_12360 ENOG41067VP Protein of unknown function (DUF1049) SB45_12365 ENOG4105NCW Trka-c domain protein SB45_12370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) SB45_12380 ENOG4105CKP Polysaccharide Biosynthesis Protein SB45_12385 ENOG4108QG2 Membrane SB45_12390 ENOG4105NAP SB45_12395 ENOG4105VIE preprotein translocase, subunit YajC SB45_12400 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) SB45_12405 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) SB45_12410 ENOG41061AI Protein of unknown function (DUF2905) SB45_12415 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) SB45_12420 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) SB45_12440 ENOG4106678 morphogenetic protein associated with SpoVID SB45_12445 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) SB45_12450 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase SB45_12455 ENOG4108IYU L-aspartate oxidase SB45_12470 ENOG4105CQC Prephenate dehydratase SB45_12480 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control SB45_12490 ENOG4105K46 50S ribosomal protein l27 SB45_12495 ENOG4105X36 (ribosomal) protein SB45_12500 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) SB45_12515 ENOG4107QMS site-determining protein SB45_12520 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) SB45_12525 ENOG4105YHC Rod shape-determining protein MreD SB45_12530 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) SB45_12535 ENOG4105DFF Rod shape-determining protein mreb SB45_12540 ENOG4105W5Q DNA repair protein (RadC SB45_12545 ENOG4108Z03 MAF-like protein SB45_12555 ENOG4106A3R peptidase SB45_12560 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase SB45_12565 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) SB45_12575 ENOG4106AR7 Spore coat protein SB45_12580 ENOG41068KH stage VI sporulation protein D SB45_12585 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SB45_12590 ENOG4105D52 delta-aminolevulinic acid dehydratase SB45_12600 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) SB45_12610 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) SB45_12620 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) SB45_12625 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) SB45_12630 ENOG4108IUQ atp-dependent protease SB45_12635 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) SB45_12640 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation SB45_12650 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SB45_12655 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SB45_12660 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SB45_12670 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase SB45_12675 ENOG4108ZP8 Acetolactate synthase small subunit SB45_12680 ENOG4105C7K acetolactate synthase SB45_12710 ENOG4107SCJ type I restriction enzyme EcoKI subunit R SB45_12730 ENOG4105M59 Phosphodiesterase, mj0936 family SB45_12735 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) SB45_12740 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) SB45_12745 ENOG4108XJQ germination protein SB45_12750 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) SB45_12755 ENOG41067TZ transcriptional regulator, MarR family SB45_12760 ENOG4105PFC Transcriptional regulator SB45_12770 ENOG4105E33 succinate dehydrogenase SB45_12780 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit SB45_12790 ENOG4105CFH Aspartokinase SB45_12795 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) SB45_12800 ENOG4105K63 Thioredoxin SB45_12805 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) SB45_12810 ENOG4105C10 Electron transfer flavoprotein SB45_12815 ENOG4105BZJ Electron transfer flavoprotein SB45_12820 ENOG41060WC Enoyl-CoA hydratase SB45_12825 ENOG4107Z3H Transcriptional regulator, TetR family SB45_12830 ENOG4105CEY Amp-dependent synthetase and ligase SB45_12845 ENOG4105C98 muts2 protein SB45_12850 ENOG4105DCG PHP domain protein SB45_12865 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) SB45_12870 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) SB45_12875 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) SB45_12880 ENOG4108RWN rrna methyltransferase SB45_12885 ENOG41067MF small acid-soluble spore protein SB45_12895 ENOG4105CQB FAD linked oxidase domain protein SB45_12900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SB45_12910 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) SB45_12915 ENOG4105DRS transport system, permease SB45_12930 ENOG4108MDK Dehydrogenase SB45_12940 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase SB45_12945 ENOG4105EF1 ribulokinase SB45_12955 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase SB45_12960 ENOG4105CN9 Peptidase m42 family protein SB45_12970 ENOG410696E Membrane SB45_12975 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) SB45_12980 ENOG4105VJV 50s ribosomal protein L35 SB45_12985 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) SB45_12990 ENOG41067MG lrgb family SB45_13000 ENOG4105DY9 regulatoR SB45_13005 ENOG4108HRK Histidine kinase SB45_13010 ENOG4105U0R haloacid dehalogenase-like hydrolase SB45_13015 ENOG4105C22 threonyL-tRNA synthetase SB45_13020 ENOG4108TDW sporulation protein YtxC SB45_13045 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) SB45_13050 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase SB45_13055 ENOG4105KVH Transcriptional regulator SB45_13060 ENOG4105F27 Major Facilitator SB45_13065 ENOG4105CV8 reductase SB45_13070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) SB45_13080 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) SB45_13085 ENOG4105C2M dna polymerase I SB45_13090 ENOG4105BZU Histidine kinase SB45_13095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SB45_13105 ENOG4108HMX isocitrate dehydrogenase (NADP) SB45_13110 ENOG4105BZN citrate synthase SB45_13115 ENOG4105G7B Protein of unknown function (DUF2992) SB45_13125 ENOG4108REF Sporulation integral membrane protein ytvi SB45_13130 ENOG4105FS0 cytoplasmic membrane protein SB45_13135 ENOG4105CA9 Pyruvate kinase SB45_13140 ENOG4105CTQ phosphohexokinase SB45_13145 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) SB45_13150 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) SB45_13160 ENOG4105C6K Malic enzyme SB45_13165 ENOG4105C0B DNA polymerase III (alpha subunit) SB45_13170 ENOG4105VV2 SB45_13180 ENOG4106EVM SB45_13185 ENOG4105SFS phosphoesterase RecJ domain protein SB45_13200 ENOG4105E8R UPF0173 metal-dependent hydrolase SB45_13210 ENOG4105CH7 arginosuccinase SB45_13215 ENOG4105CDH Citrulline--aspartate ligase SB45_13220 ENOG4105EPU Molybdenum cofactor synthesis domain protein SB45_13225 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) SB45_13235 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) SB45_13240 ENOG4105KBJ sporulation protein ytfj SB45_13250 ENOG4105VK3 rdd domain containing protein SB45_13255 ENOG4105D07 Signal peptide peptidase, SppA SB45_13260 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) SB45_13265 ENOG4105EFZ amidohydrolase SB45_13270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SB45_13280 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) SB45_13305 ENOG4105U5Y Transcriptional regulator SB45_13315 ENOG4105BZU Histidine kinase SB45_13320 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) SB45_13325 ENOG4105C26 Dehydrogenase SB45_13335 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) SB45_13345 ENOG4108Z0Z intracellular protease Pfpi family SB45_13365 ENOG4108NGU Transcriptional regulator SB45_13380 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) SB45_13390 ENOG4105F1V Acetoin utilization protein SB45_13395 ENOG4105W87 Cbs domain SB45_13400 ENOG4105DGU Histone deacetylase SB45_13405 ENOG4105ER2 Ompa motb domain protein SB45_13410 ENOG4107R0U MotA TolQ exbB proton channel SB45_13415 ENOG4105ETE Transcriptional regulator (LacI family SB45_13420 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase SB45_13440 ENOG4105DFU Cell wall formation (By similarity) SB45_13450 ENOG4108VDD TRNA binding domain protein SB45_13465 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ SB45_13480 ENOG4105C6K Malic enzyme SB45_13485 ENOG4105C8F Beta-lactamase domain protein SB45_13490 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) SB45_13500 ENOG4108V15 phosphotransferase enzyme family SB45_13515 ENOG4107F58 2'-5' rna ligase SB45_13520 ENOG4105C6T cysteine synthase SB45_13525 ENOG4107QSE Dipeptidase SB45_13530 ENOG4105C7N Xanthine uracil vitamin C permease SB45_13555 ENOG4105CBX hi0933 family SB45_13560 ENOG4105C94 Transporter SB45_13580 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component SB45_13585 ENOG4105I1K ABC transporter SB45_13600 ENOG41085GJ domain protein SB45_13605 ENOG4105C8T Leucyl-tRNA synthetase SB45_13615 ENOG4105BZU Histidine kinase SB45_13620 ENOG410605W Major Facilitator SB45_13635 ENOG4105C19 ABC transporter SB45_13640 ENOG4105EWM Histidine kinase SB45_13650 ENOG4107R34 abc transporter permease protein SB45_13655 ENOG4105C19 ABC transporter SB45_13675 ENOG4105DVE abc transporter atp-binding protein SB45_13680 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family SB45_13690 ENOG4105N5T Radical SAM Protein SB45_13705 ENOG4107VXM glycerophosphoryl diester phosphodiesterase SB45_13715 ENOG4105E8V Alpha Beta Hydrolase Fold protein SB45_13720 ENOG4108Z0R Transferase SB45_13725 ENOG4105C85 amino acid SB45_13730 ENOG4105CAQ asparagine synthetase SB45_13735 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP SB45_13740 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase SB45_13755 ENOG4105D2X ABC transporter substrate-binding protein SB45_13765 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component SB45_13780 ENOG4108RMU ferritin dps family protein SB45_13795 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) SB45_13800 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) SB45_13805 ENOG4108V2W Carbonate dehydratase SB45_13810 ENOG4105NRA 50s ribosomal protein l31 type b SB45_13825 ENOG4105DTQ mandelate racemase muconate lactonizing SB45_13830 ENOG4105CEY Amp-dependent synthetase and ligase SB45_13835 ENOG4108IPT Naphthoate synthase SB45_13840 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) SB45_13845 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) SB45_13850 ENOG4105E4F Isochorismate synthase SB45_13980 ENOG4105N67 Proton-coupled thiamine transporter YuaJ SB45_13985 ENOG4105DZ6 Band 7 protein SB45_13995 ENOG4106DF1 SB45_14000 ENOG4108VNY MOSC domain protein SB45_14005 ENOG4108JB8 alcohol dehydrogenase SB45_14010 ENOG4105C26 Dehydrogenase SB45_14015 ENOG4105TRT Transcriptional regulator SB45_14030 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj SB45_14035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) SB45_14055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) SB45_14065 ENOG4105EE0 oxidoreductase SB45_14070 ENOG4108Z0Z intracellular protease Pfpi family SB45_14075 ENOG4105C8Q Methyl-accepting chemotaxis SB45_14080 ENOG4105C8Q Methyl-accepting chemotaxis SB45_14085 ENOG4105C8Q Methyl-accepting chemotaxis SB45_14090 ENOG4105C8Q Methyl-accepting chemotaxis SB45_14105 ENOG4105EA8 2-Nitropropane dioxygenase SB45_14110 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme SB45_14120 ENOG4105C37 (CBS) domain SB45_14135 ENOG4107PBV potassium channel SB45_14140 ENOG4107PBV potassium channel SB45_14155 ENOG4107QYV phosphohexose isomerase SB45_14165 ENOG4105CHJ isochorismatase hydrolase SB45_14175 ENOG4107QW4 alcohol dehydrogenase SB45_14180 ENOG4105WG9 Conserved Protein SB45_14190 ENOG4105CHM Aminotransferase SB45_14195 ENOG4108ZB6 transcriptional regulator AsnC family SB45_14200 ENOG4108MUZ hydrolase SB45_14210 ENOG4105C87 Aminotransferase class I and II SB45_14215 ENOG4108HGU Histidine kinase SB45_14220 ENOG4105Y38 Kinase-associated protein B SB45_14235 ENOG4105BZ4 penicillin-binding protein SB45_14240 ENOG4105KIR Thiol-disulfide oxidoreductase dcc SB45_14255 ENOG4108MRH transcriptional regulatory protein SB45_14260 ENOG4105DIH basic membrane SB45_14265 ENOG4108JQ9 ABC transporter SB45_14270 ENOG4105UIB (ABC) transporter SB45_14285 ENOG4105D65 subunit l SB45_14290 ENOG4105HC0 Na H antiporter SB45_14295 ENOG4108ZE9 Monovalent cation H antiporter subunit C SB45_14300 ENOG4108JPZ Monovalent cation H antiporter subunit D SB45_14305 ENOG4105SC1 monovalent cation H antiporter subunit E SB45_14315 ENOG4105KJM monovalent cation h antiporter subunit g SB45_14320 ENOG4105KA0 thioesterase Superfamily protein SB45_14330 ENOG4105BZU Histidine kinase SB45_14355 ENOG4105D58 Diguanylate phosphodiesterase SB45_14360 ENOG4105DAP Nicotinate phosphoribosyltransferase SB45_14385 ENOG4105C02 permease SB45_14400 ENOG410904N short-chain dehydrogenase reductase SB45_14435 ENOG4108K8K Transcriptional regulator SB45_14440 ENOG4105DCF alanine dehydrogenase SB45_14450 ENOG4105WQT MbtH domain protein SB45_14455 ENOG4105CEY Amp-dependent synthetase and ligase SB45_14460 ENOG4105WQI isochorismatase SB45_14465 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase SB45_14470 ENOG4105E4F Isochorismate synthase SB45_14475 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase SB45_14480 ENOG4105NIV Esterase SB45_14500 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) SB45_14510 ENOG41069ER domain protein SB45_14520 ENOG4105CEP NADH dehydrogenase SB45_14535 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) SB45_14550 ENOG4105CJ1 ABC, transporter SB45_14575 ENOG4108VHC Short-chain dehydrogenase reductase Sdr SB45_14580 ENOG4108YX9 iron--sulfur cluster insertion protein erpA SB45_14585 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) SB45_14595 ENOG4105ZKE UPF0349 protein SB45_14610 ENOG41083MR nifu domain-containing protein SB45_14615 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein SB45_14620 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) SB45_14625 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) SB45_14630 ENOG4105D6E homoserine dehydrogenase SB45_14640 ENOG4108W5N phosphatidylglycerophosphatase a SB45_14645 ENOG4105D4U had-superfamily hydrolase, subfamily iia SB45_14655 ENOG4105MMD transcriptional regulator SB45_14660 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) SB45_14665 ENOG4105FAA peptidase M23 SB45_14670 ENOG4108YTE sporulation protein YunB SB45_14675 ENOG4107R8B 5'-nucleotidase SB45_14685 ENOG4105I3N Conserved Protein SB45_14695 ENOG4105CD3 dihydroorotase SB45_14700 ENOG4105G9B Transcriptional regulator SB45_14730 ENOG4105C5R Aminotransferase SB45_14740 ENOG4108K8S endonuclease I SB45_14745 ENOG4108IJ9 (ABC) transporter SB45_14750 ENOG4105FDP GntR family transcriptional regulator SB45_14755 ENOG4108KPW sugar kinase SB45_14760 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component SB45_14765 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component SB45_14770 ENOG4105XN3 extracellular solute-binding protein family 1 SB45_14775 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine SB45_14785 ENOG4105PKS Excinuclease abc c subunit domain protein SB45_14790 ENOG4107VFR oxidoreductase SB45_14800 ENOG41083Q9 chitosanase SB45_14805 ENOG4105DIW FeS assembly protein SUFB SB45_14810 ENOG4108UNV SUF system FeS assembly protein, NifU family SB45_14815 ENOG4105C9B Cysteine desulfurase SB45_14820 ENOG4105JRK feS assembly protein SufD SB45_14825 ENOG4105C3K feS assembly ATPase SufC SB45_14835 ENOG4105D01 (LipO)protein SB45_14840 ENOG4108UMI ABC transporter, permease SB45_14845 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) SB45_14870 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) SB45_14875 ENOG41080E8 Transcriptional regulator, Spx MgsR family SB45_14880 ENOG4105C1G acyl-Coa dehydrogenase SB45_14885 ENOG4105CHU acetyl-coa acetyltransferase SB45_14910 ENOG41067TZ transcriptional regulator, MarR family SB45_14915 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB45_14920 ENOG4105C5Q Transcriptional regulator SB45_14940 ENOG4105E0A ABC, transporter SB45_14955 ENOG4105E1F short-chain dehydrogenase reductase SB45_14960 ENOG4105HUF DNA protection during starvation protein SB45_14965 ENOG4105C0H protease SB45_14975 ENOG4105F3H Histidine kinase SB45_14980 ENOG41067SE Tetr family transcriptional regulator SB45_14985 ENOG4105C9Q fumarate hydratase class II SB45_15010 ENOG4105WH1 Two component transcriptional regulator luxr family SB45_15015 ENOG4105ENE Histidine kinase SB45_15030 ENOG41087YS Phage shock protein A SB45_15045 ENOG4108WBT adenosyltransferase SB45_15050 ENOG4105E0A ABC, transporter SB45_15055 ENOG4105EHG Permease protein SB45_15060 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) SB45_15065 ENOG4105EWI Short-chain dehydrogenase reductase Sdr SB45_15070 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein SB45_15080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SB45_15090 ENOG4106DF4 Sigma-70, region 4 SB45_15095 ENOG4105F0F Oxalate decarboxylase SB45_15105 ENOG4105E0A ABC, transporter SB45_15110 ENOG4105EHG Permease protein SB45_15115 ENOG4105DQ5 transport system permease protein SB45_15125 ENOG4105JQZ Methyltransferase SB45_15130 ENOG4105D5Q Arginine ornithine antiporter SB45_15140 ENOG4107K5X Membrane-bound metal-dependent hydrolase SB45_15145 ENOG4107QZ2 Sulfatase SB45_15150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family SB45_15155 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein SB45_15160 ENOG4105E0C molybdate abc transporter SB45_15165 ENOG4105WH1 Two component transcriptional regulator luxr family SB45_15170 ENOG4105BZU Histidine kinase SB45_15175 ENOG4105CJ1 ABC, transporter SB45_15185 ENOG4108KYE ABC-2 type transporter SB45_15200 ENOG4105EEQ Na H antiporter SB45_15210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) SB45_15215 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SB45_15220 ENOG4105EEM helicase SB45_15225 ENOG4105EN6 Membrane SB45_15240 ENOG4107ZQN disulfide bond SB45_15245 ENOG4105C59 p-type ATPase SB45_15250 ENOG4105C59 p-type ATPase SB45_15255 ENOG410681U heavy metal transport detoxification protein SB45_15260 ENOG4105VPX protein, conserved in bacteria SB45_15265 ENOG4105D9R oxidoreductase SB45_15270 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) SB45_15305 ENOG4105DEN Luciferase family SB45_15310 ENOG4105CDA abc transporter atp-binding protein SB45_15335 ENOG4108XSB acetyltransferase, (GNAT) family SB45_15340 ENOG4108KSA LysR family transcriptional regulator SB45_15345 ENOG4105EWI Short-chain dehydrogenase reductase Sdr SB45_15350 ENOG41067XF inhibitor SB45_15355 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) SB45_15360 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) SB45_15370 ENOG4105XZU Preprotein translocase, subunit SecG SB45_15390 ENOG4105KVH Transcriptional regulator SB45_15415 ENOG4105DA5 (ABC) transporter SB45_15420 ENOG4105R40 Glycine betaine carnitine choline SB45_15425 ENOG4108HQR Glycine betaine SB45_15430 ENOG4105E90 ABC transporter SB45_15435 ENOG4108IJ8 ABC transporter SB45_15440 ENOG4107HG4 Transcriptional regulator SB45_15445 ENOG4105R40 Glycine betaine carnitine choline SB45_15450 ENOG4108HQR Glycine betaine SB45_15455 ENOG4105E90 ABC transporter SB45_15460 ENOG4108IJ8 ABC transporter SB45_15465 ENOG4107HG4 Transcriptional regulator SB45_15470 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein SB45_15480 ENOG4105T65 Membrane-associated protein SB45_15485 ENOG4108W0I acetyltransferase SB45_15500 ENOG4105FJR Lmbe family SB45_15515 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SB45_15520 ENOG4108IAJ Nad-dependent epimerase dehydratase SB45_15525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SB45_15530 ENOG4107QQG Dehydrogenase SB45_15535 ENOG4105IIU Aminopeptidase SB45_15540 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) SB45_15545 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) SB45_15550 ENOG4105CP7 Triose-phosphate isomerase SB45_15555 ENOG4105BZA Phosphoglycerate kinase SB45_15565 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase SB45_15580 ENOG4105CMD Transcriptional regulator, GntR family SB45_15585 ENOG4105DEN Luciferase family SB45_15595 ENOG4105GZI Transcriptional regulator SB45_15600 ENOG4107RT3 EamA-like transporter family SB45_15610 ENOG4106KNT transcriptional regulator SB45_15615 ENOG4105CMG Carbohydrate kinase SB45_15620 ENOG4105C6Z Gluconate SB45_15630 ENOG4107QR9 Iron-sulfur cluster binding protein SB45_15635 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SB45_15640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SB45_15645 ENOG4105JXH GntR family transcriptional regulator SB45_15650 ENOG4105DAA L-lactate SB45_15655 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB45_15665 ENOG4108ZPC Polysaccharide pyruvyl transferase SB45_15670 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SB45_15675 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family SB45_15680 ENOG4105D3Q Sugar transferase SB45_15690 ENOG4105K64 Glycosyl transferase, family 2 SB45_15700 ENOG4107QRS glycosyltransferase group 2 family protein SB45_15705 ENOG41068W6 Capsular polysaccharide biosynthesis protein SB45_15710 ENOG4108KMV Glycosyl transferase (Group 1 SB45_15715 ENOG4105K64 Glycosyl transferase, family 2 SB45_15720 ENOG4108PQP glycosyl transferase group 1 SB45_15730 ENOG4108QV3 biosynthesis protein SB45_15735 ENOG4105HTX biosynthesis protein SB45_15745 ENOG4105EBR Carboxylesterase SB45_15750 ENOG4105NAE bifunctional deaminase-reductase domain protein SB45_15760 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 SB45_15765 ENOG4105PY6 Phenolic acid decarboxylase SB45_15810 ENOG4108HKT sucrose-6-phosphate hydrolase SB45_15815 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) SB45_15820 ENOG4105ETE Transcriptional regulator (LacI family SB45_15825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) SB45_15830 ENOG4108KAM Transcriptional regulator SB45_15835 ENOG4105C7F AcnD-accessory protein PrpF SB45_15845 ENOG4108URH decarboxylase SB45_15850 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain SB45_15855 ENOG4105CHH sulfate transporter SB45_15860 ENOG4108V2W Carbonate dehydratase SB45_15870 ENOG4105C5I Dehydrogenase SB45_15875 ENOG4105GGE ribonuclease SB45_15880 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase SB45_15885 ENOG4105KRI phosphocarrier protein (HPr SB45_15890 ENOG4105CIE May be required for sporulation (By similarity) SB45_15895 ENOG4105CHW UPF0052 protein SB45_15900 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) SB45_15905 ENOG4108Z4K mutator MutT protein SB45_15910 ENOG4105C3M thioredoxin reductase SB45_15925 ENOG4105BZU Histidine kinase SB45_15930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB45_15940 ENOG4105BZ1 (ABC) transporter SB45_15945 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase SB45_15950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) SB45_15955 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase SB45_15960 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) SB45_15965 ENOG4105ECC imidazole-glycerol-phosphate dehydratase SB45_15970 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) SB45_15975 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) SB45_15980 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) SB45_15990 ENOG4108S4C acetyltransferase SB45_15995 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) SB45_16005 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) SB45_16010 ENOG4105CE4 GlcNAc 6-P deacetylase SB45_16015 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) SB45_16020 ENOG4105FDP GntR family transcriptional regulator SB45_16025 ENOG4105J7D transcriptional regulator SB45_16030 ENOG41088CQ domain protein SB45_16035 ENOG41086DT Membrane protein of unknown function SB45_16040 ENOG41067S9 phage shock protein C, PspC SB45_16045 ENOG4108PY7 SB45_16060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) SB45_16065 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) SB45_16080 ENOG4105MKU Transcriptional regulator SB45_16120 ENOG4105CN1 protease SB45_16125 ENOG4108M26 parallel beta-helix repeat protein SB45_16130 ENOG4105CRP Part of the ABC transporter FtsEX involved in SB45_16135 ENOG4105CAK Cell division ATP-binding protein ftsE SB45_16150 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) SB45_16155 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving SB45_16160 ENOG4105MS2 ribosomal subunit Interface protein SB45_16175 ENOG4105MQ3 flagellar protein FliS SB45_16180 ENOG4107RT6 flagellar hook-associated SB45_16185 ENOG4105I03 Flagellin SB45_16190 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) SB45_16195 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) SB45_16205 ENOG4105DTJ flagellar hook-associated protein SB45_16210 ENOG4105E1Q flagellar hook-associated protein SB45_16225 ENOG4105RU3 SB45_16230 ENOG41081UC Inherit from COG: Competence protein SB45_16250 ENOG4105WH1 Two component transcriptional regulator luxr family SB45_16255 ENOG4105BZU Histidine kinase SB45_16260 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein SB45_16265 ENOG4108KGH TRANSCRIPTIONal SB45_16270 ENOG4105ESV Glycosyl transferase, family 4 SB45_16275 ENOG4107EF8 Glycosyl transferase (Group 1 SB45_16290 ENOG4105QZI O-Antigen Polymerase SB45_16295 ENOG4105C6Y Udp-glucose 6-dehydrogenase SB45_16300 ENOG4107RA4 Glycosyl transferase (Group 1 SB45_16305 ENOG4105PSV Polysaccharide Biosynthesis Protein SB45_16310 ENOG4105D3Q Sugar transferase SB45_16315 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SB45_16320 ENOG4105JFG SpoIID LytB domain protein SB45_16335 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase SB45_16340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SB45_16345 ENOG4105EY8 ABC transporter SB45_16355 ENOG4107SJB teichoic acid biosynthesis SB45_16365 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase SB45_16375 ENOG4107RZX Teichoic acid biosynthesis protein SB45_16385 ENOG4105DG6 mannose-6-phosphate isomerase SB45_16400 ENOG4108NHD germination protein SB45_16405 ENOG4107R8N Glycosyl transferase, family 2 SB45_16410 ENOG4105C54 Major Facilitator superfamily SB45_16415 ENOG4108KGH TRANSCRIPTIONal SB45_16420 ENOG4105J7I hydrolase SB45_16425 ENOG4106UBQ SB45_16430 ENOG4105K4H Nlp p60 protein SB45_16435 ENOG4105PNM synthesis protein SB45_16445 ENOG4105N98 Capsule biosynthesis protein capB SB45_16450 ENOG4105E1K spore germination protein SB45_16465 ENOG4105ETE Transcriptional regulator (LacI family SB45_16470 ENOG4108RVA ribokinase SB45_16475 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) SB45_16480 ENOG4105C2J ABC transporter SB45_16485 ENOG4105CNN ABC, transporter SB45_16490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator SB45_16500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein SB45_16505 ENOG4107FQX Alpha-acetolactate decarboxylase SB45_16515 ENOG4107RSM transcriptional regulator SB45_16530 ENOG4106UIA SB45_16545 ENOG4107XC4 flavin reductase domain protein, FMN-binding SB45_16565 ENOG4105CAH Chromate SB45_16570 ENOG4105FGV Chromate SB45_16580 ENOG4108WS4 fmn reductase SB45_16585 ENOG4107V2S Transcriptional regulator SB45_16590 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) SB45_16620 ENOG4108XI2 Domain of unknown function (DUF1963) SB45_16625 ENOG4105C6Y Udp-glucose 6-dehydrogenase SB45_16630 ENOG4108RB3 Capsular polysaccharide biosynthesis protein SB45_16635 ENOG4107YJ4 chain length determinant protein SB45_16640 ENOG4105HTX biosynthesis protein SB45_16650 ENOG4105KBK Zinc finger, swim domain protein SB45_16655 ENOG4105C0D helicase SB45_16660 ENOG410667J hydrolase SB45_16665 ENOG4105E98 transcriptional regulator DeoR family SB45_16670 ENOG4105Z8H single-stranded DNA-binding protein SB45_16685 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) SB45_16690 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) SB45_16700 ENOG4105CGA flagellar basal-body rod protein FlgG SB45_16710 ENOG4105DFF Rod shape-determining protein mreb SB45_16715 ENOG4105MT0 Sporulation transcriptional regulator spoiiid SB45_16720 ENOG4107MII Sugar-specific transcriptional regulator TrmB SB45_16725 ENOG4105CZM Major Facilitator SB45_16730 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease SB45_16735 ENOG41080V3 Major Facilitator superfamily SB45_16740 ENOG4105D3W isochorismatase SB45_16745 ENOG4105BZU Histidine kinase SB45_16755 ENOG4105CNI cell division protein FtsW SB45_16760 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase SB45_16770 ENOG4105FRN stage II sporulation protein SB45_16775 ENOG4107TCE N-acetyltransferase SB45_16790 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) SB45_16795 ENOG4106BRK SB45_16800 ENOG4107T94 Endo-14-beta-xylanase SB45_16810 ENOG4108Z40 Transcriptional regulator SB45_16815 ENOG4105CQM Urea amidohydrolase subunit alpha SB45_16820 ENOG4105KI2 Urea amidohydrolase subunit beta SB45_16825 ENOG4108YZ9 Urea amidohydrolase subunit gamma SB45_16845 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) SB45_16850 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) SB45_16855 ENOG4108TF4 von Willebrand factor, type A SB45_16870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SB45_16880 ENOG4106778 Protein of unknown function (DUF1146) SB45_16890 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) SB45_16895 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) SB45_16900 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) SB45_16905 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) SB45_16910 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) SB45_16925 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) SB45_16935 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) SB45_16940 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) SB45_16945 ENOG4108UIC UPF0340 protein SB45_16950 ENOG4108YZG isomerase SB45_16955 ENOG4107WAU Protein tyrosine phosphatase SB45_16960 ENOG410815N Probably functions as a manganese efflux pump (By similarity) SB45_16965 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SB45_16975 ENOG4108ZXQ stage ii sporulation protein r SB45_16990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) SB45_16995 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) SB45_17000 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase SB45_17010 ENOG4107TT2 Auxin Efflux Carrier SB45_17015 ENOG4105C6K Malic enzyme SB45_17020 ENOG4107104 thymidine kinase SB45_17025 ENOG41082DI 50s ribosomal protein l31 SB45_17030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) SB45_17035 ENOG4105CBT Fructose-1,6-bisphosphatase SB45_17040 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SB45_17050 ENOG4105D2N Aldolase SB45_17055 ENOG410812K response regulator receiver protein SB45_17065 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) SB45_17075 ENOG4105DF6 Fe-S oxidoreductase SB45_17085 ENOG4105E5J UV damage endonuclease SB45_17095 ENOG4105BZ1 (ABC) transporter SB45_17100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) SB45_17115 ENOG4105R3A Nitrate reductase SB45_17120 ENOG4108IUE nitrate reductase beta subunit SB45_17140 ENOG4107V6Q Cyclic nucleotide-binding domain SB45_17150 ENOG4105C75 arginyL-tRNA synthetase SB45_17155 ENOG410684U Domain of unknown function (DUF1934) SB45_17160 ENOG4107JM4 Tetratricopeptide repeat SB45_17195 ENOG4105CYW agmatinase SB45_17200 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) SB45_17205 ENOG4105BZ4 penicillin-binding protein SB45_17215 ENOG4108XFG YwhD family SB45_17220 ENOG4108Z4T Peptidase M50 SB45_17225 ENOG41069HH 4-oxalocrotonate tautomerase SB45_17230 ENOG41067TZ transcriptional regulator, MarR family SB45_17240 ENOG4105CUB amino acid SB45_17250 ENOG4105DCI Phosphohydrolase SB45_17260 ENOG4108VCI transcription factor, rsfa family SB45_17265 ENOG4105K7K Transcriptional regulator SB45_17275 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) SB45_17280 ENOG4105DUM transcriptional regulator, lysR family SB45_17285 ENOG4105HMI Membrane SB45_17290 ENOG4108IJ2 phosphate acetyltransferase SB45_17295 ENOG4107JTW chlorite dismutase SB45_17305 ENOG4105CHM Aminotransferase SB45_17335 ENOG4105FCW Major Facilitator superfamily SB45_17340 ENOG4105C2C drug resistance transporter, Bcr CflA SB45_17355 ENOG4105C26 Dehydrogenase SB45_17360 ENOG4105D82 Glutamate dehydrogenase SB45_17370 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase SB45_17375 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase SB45_17380 ENOG4105C1B dTDP-glucose 4-6-dehydratase SB45_17385 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) SB45_17390 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG SB45_17395 ENOG4107TY6 Acylneuraminate cytidylyltransferase SB45_17405 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD SB45_17410 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SB45_17445 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) SB45_17450 ENOG4108RJ9 Glycosyl transferase, family 2 SB45_17470 ENOG4105DWF phosphomethylpyrimidine kinase SB45_17485 ENOG4105C5Y PTS System SB45_17500 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin SB45_17505 ENOG4105DEN Luciferase family SB45_17510 ENOG4108DBC nitroreductase SB45_17515 ENOG4105C19 ABC transporter SB45_17540 ENOG4105I4A GCN5-related N-acetyltransferase SB45_17560 ENOG4105BZ9 Cytochrome C oxidase, subunit I SB45_17565 ENOG4105E2S oxidase) subunit II SB45_17570 ENOG4107BMA Transglycosylase associated protein SB45_17580 ENOG4105WH5 Teichoic acid glycosylation protein SB45_17605 ENOG4107ZXU DSBA oxidoreductase SB45_17610 ENOG4105DBE peroxidase SB45_17615 ENOG410650H (LipO)protein SB45_17620 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) SB45_17625 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase SB45_17630 ENOG4105CMU LysR family (Transcriptional regulator SB45_17635 ENOG4105VAW lrga family SB45_17640 ENOG41067MG lrgb family SB45_17650 ENOG4107TXC Transcriptional regulator SB45_17655 ENOG4105DR4 Methyltransferase SB45_17665 ENOG4105CK1 PTS System SB45_17670 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin SB45_17675 ENOG4105X1N Glycosyl transferase family 8 SB45_17685 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase SB45_17695 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) SB45_17700 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein SB45_17705 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) SB45_17710 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD SB45_17715 ENOG4105CM2 brancheD-chain amino acid aminotransferase SB45_17720 ENOG4105F8D glycoside hydrolase family 4 SB45_17725 ENOG4105VCP PTS System SB45_17730 ENOG4105CK1 PTS System SB45_17735 ENOG4105VZJ PTS System SB45_17740 ENOG4105EMD TRANSCRIPTIONal SB45_17750 ENOG4105DQ5 transport system permease protein SB45_17755 ENOG4105EHG Permease protein SB45_17765 ENOG41082YX Transcriptional regulator, arsr family SB45_17770 ENOG4107R5R arsenical pump membrane protein SB45_17775 ENOG4105VZJ PTS System SB45_17780 ENOG4105VCP PTS System SB45_17785 ENOG4105CK1 PTS System SB45_17790 ENOG4105CS2 ec 3.2.1.21 SB45_17795 ENOG4105EVU fructokinase SB45_17800 ENOG4105DG6 mannose-6-phosphate isomerase SB45_17810 ENOG4105CH6 catalase SB45_17815 ENOG4107QHE Choloylglycine hydrolase SB45_17820 ENOG4105ETS cytosine purines uracil thiamine allantoin SB45_17825 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) SB45_17830 ENOG4108JJ8 (ABC) transporter SB45_17835 ENOG4108JJ9 ABC, transporter SB45_17840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii SB45_17845 ENOG4105C4M (Ubiquinol oxidase) subunit I SB45_17850 ENOG4105D2K citrate carrier protein SB45_17855 ENOG4107BJW polysaccharide deacetylase SB45_17870 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) SB45_17880 ENOG4105CMR udp-glucose 4-epimerase SB45_17885 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SB45_17900 ENOG4105DHI Methyltransferase SB45_17925 ENOG4105CH6 catalase SB45_17930 ENOG4105D4T Citrate transporter SB45_17945 ENOG4105DEU major facilitator superfamily SB45_17950 ENOG4105C1J atp-dependent rna helicase SB45_18015 ENOG4108NR7 pectate lyase SB45_18025 ENOG4107YZX Universal stress protein SB45_18030 ENOG4105CS2 ec 3.2.1.21 SB45_18035 ENOG4105C5Y PTS System SB45_18050 ENOG4106Z5D Glycoside Hydrolase Family 43 SB45_18060 ENOG4105C84 Histidine ammonia-lyase SB45_18065 ENOG4105CGP Urocanate hydratase SB45_18070 ENOG4105CI2 imidazolone-5-propionate hydrolase SB45_18075 ENOG4107W25 arginase agmatinase formiminoglutamase SB45_18085 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) SB45_18090 ENOG4105D9N nucleoside SB45_18095 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) SB45_18100 ENOG4107RHR regulatoR SB45_18105 ENOG410667J hydrolase SB45_18135 ENOG4108V5C ABC transporter SB45_18170 ENOG4105WZ4 isomerase SB45_18175 ENOG4105F0H myo-inositol catabolism protein SB45_18180 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) SB45_18190 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) SB45_18200 ENOG4105EDK PfkB domain protein SB45_18210 ENOG4105C26 Dehydrogenase SB45_18220 ENOG4105CPC Aldo Keto reductase SB45_18225 ENOG4107QNK )-transporter SB45_18230 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) SB45_18240 ENOG41061TZ Short-chain dehydrogenase reductase Sdr SB45_18245 ENOG4108S01 response regulator SB45_18250 ENOG4108ZGX Histidine kinase SB45_18255 ENOG4105ECK Fatty Acid Desaturase SB45_18265 ENOG4105ST3 Transcriptional regulator SB45_18270 ENOG4105C26 Dehydrogenase SB45_18275 ENOG4108ITS PQQ enzyme repeat SB45_18285 ENOG4105WAB arsR family transcriptional regulator SB45_18290 ENOG4105F27 Major Facilitator SB45_18295 ENOG41085PJ rdd domain containing protein SB45_18305 ENOG4105D3R alkyl hydroperoxide reductase SB45_18310 ENOG4108JU3 Alkyl hydroperoxide reductase SB45_18315 ENOG4105C85 amino acid SB45_18320 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 SB45_18325 ENOG4108XHQ (2Fe-2S)-binding domain protein SB45_18345 ENOG4105XRQ Xanthine dehydrogenase accessory factor SB45_18365 ENOG4107QJE Chromosome Partitioning Protein SB45_18370 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) SB45_18385 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) SB45_18390 ENOG4105CPC Aldo Keto reductase SB45_18395 ENOG4105WQG acetyltransferase SB45_18405 ENOG41066UZ arginase EC 3.5.3.1 SB45_18410 ENOG4108IQI permease SB45_18415 ENOG4105C8Y Acetylornithine aminotransferase SB45_18425 ENOG41082BM Transcriptional regulator, arsr family SB45_18430 ENOG4108JUB Transcriptional regulator SB45_18440 ENOG4105C5H ABC transporter SB45_18455 ENOG4105D06 uba thif-type nad fad binding protein SB45_18460 ENOG4105BZU Histidine kinase SB45_18470 ENOG4105C0H protease SB45_18475 ENOG4105Q2H domain protein SB45_18490 ENOG4105BZU Histidine kinase SB45_18495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB45_18525 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis SB45_18530 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase SB45_18535 ENOG4105CDU Replicative dna helicase SB45_18555 ENOG4107QPH glycogen) synthase SB45_18565 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR SB45_18570 ENOG4105CPK Glycosyl transferase (Group 1 SB45_18590 ENOG4105BZR domain protein SB45_18595 ENOG4108XMW Membrane SB45_18610 ENOG4105KVH Transcriptional regulator SB45_18615 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase SB45_18620 ENOG4108UZ3 Transporter SB45_18625 ENOG4105EDQ levansucrase EC 2.4.1.10 SB45_18630 ENOG4108HKT sucrose-6-phosphate hydrolase SB45_18635 ENOG4107XBN GntR Family Transcriptional Regulator SB45_18655 ENOG4108TVJ Nitroreductase SB45_18660 ENOG4105FS7 Transcriptional regulator SB45_18670 ENOG4108U05 Transcriptional regulator SB45_18685 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase SB45_18690 ENOG4105CMU LysR family (Transcriptional regulator SB45_18695 ENOG4105DTD Dehydrogenase SB45_18705 ENOG4107Y9U Membrane SB45_18725 ENOG4105C7Z Conserved Protein SB45_18730 ENOG4107FCW Abortive infection protein SB45_18740 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase SB45_18750 ENOG4105CGK Exodeoxyribonuclease III SB45_18755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) SB45_18765 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) SB45_18770 ENOG4108UUM single-stranded DNA-binding protein SB45_18775 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) SB45_18780 ENOG4105C3G gtp-binding protein SB45_18785 ENOG4108J2R molybdopterin oxidoreductase SB45_18790 ENOG4105VDK protein, conserved in bacteria SB45_18805 ENOG4108ZDA Sporulation protein YyaC SB45_18810 ENOG4105FA0 parb-like partition protein SB45_18815 ENOG4107QJE Chromosome Partitioning Protein SB45_18830 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) SB45_18835 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) SB45_18850 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) SB45_18855 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) SB45_18860 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) SB45_18865 ENOG410848D S4 domain protein YaaA SB45_18870 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) SB45_18880 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SB45_18885 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)