locus-tag class description XM40_00010 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) XM40_00020 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) XM40_00025 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) XM40_00030 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) XM40_00035 ENOG4105BZW Glycerate kinase XM40_00045 ENOG4105ZMH deoxynucleoside kinase XM40_00055 ENOG4105VRS hydrolase family 18 XM40_00060 ENOG4105GTG Isochorismatase XM40_00065 ENOG4108Z6B deaminase XM40_00070 ENOG4105C6E dna polymerase iii XM40_00075 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) XM40_00080 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) XM40_00090 ENOG41067KS pro-sigma K processing XM40_00120 ENOG4105CDW Resistance protein XM40_00125 ENOG4105CXN decarboxylase XM40_00130 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) XM40_00135 ENOG4105X0R protein from nitrogen regulatory protein P-II XM40_00140 ENOG4105XVJ Protein of unknown function (DUF327) XM40_00145 ENOG4105FA2 dna polymerase iii XM40_00150 ENOG4105MA4 psp1 domain protein XM40_00160 ENOG41060K3 Methyltransferase XM40_00165 ENOG4105VC4 domain protein XM40_00170 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) XM40_00175 ENOG4105KRN Transcriptional regulator, abrb family XM40_00180 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) XM40_00185 ENOG4105F8V Hydrolase, tatD family XM40_00190 ENOG41069ER domain protein XM40_00200 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) XM40_00205 ENOG4105XFA sporulation peptidase YabG XM40_00210 ENOG4105W42 Veg protein XM40_00215 ENOG4105XEW small acid-soluble spore protein XM40_00220 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) XM40_00225 ENOG4105DFT pur operon repressor XM40_00230 ENOG4105KME endoribonuclease L-psp XM40_00235 ENOG4105K4W Could be involved in septation (By similarity) XM40_00240 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) XM40_00245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase XM40_00250 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) XM40_00265 ENOG4108JA2 transcriptioN-repair coupling factor XM40_00270 ENOG4108M14 stage v sporulation protein t XM40_00280 ENOG4108IY2 MazG family XM40_00285 ENOG41082I2 s4 domain protein XM40_00290 ENOG4105VYY sporulation protein yabp XM40_00305 ENOG41060GV RNA binding s1 domain protein XM40_00335 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) XM40_00340 ENOG4108UGV hypoxanthine phosphoribosyltransferase XM40_00345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) XM40_00350 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) XM40_00355 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) XM40_00360 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase XM40_00365 ENOG4105C6T cysteine synthase XM40_00370 ENOG4105CRQ synthase (Component I) XM40_00375 ENOG4105DDQ anthranilate synthase XM40_00380 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 XM40_00385 ENOG4105EEI dihydropteroate synthase XM40_00390 ENOG4105KRF dihydroneopterin aldolase XM40_00395 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase XM40_00405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) XM40_00410 ENOG4105CRK lysyL-tRNA synthetase XM40_00495 ENOG4108Z0C Uvrb UvrC protein XM40_00500 ENOG41066A3 ATP guanido phosphotransferase XM40_00510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) XM40_00515 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) XM40_00520 ENOG4105CTP PilT protein domain protein XM40_00525 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) XM40_00530 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) XM40_00535 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) XM40_00540 ENOG4105D7W serine acetyltransferase XM40_00550 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) XM40_00555 ENOG4105C2N RNA methyltransferase TrmH family group 3 XM40_00560 ENOG4105M0M Tetracycline resistance protein XM40_00580 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) XM40_00585 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) XM40_00595 ENOG4108VZM 50s ribosomal protein L10 XM40_00600 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) XM40_00605 ENOG4107Y49 methyltransferase XM40_00610 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) XM40_00615 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) XM40_00620 ENOG4105XPM ribosomal protein XM40_00625 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) XM40_00630 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) XM40_00635 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) XM40_00640 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) XM40_00645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase XM40_00650 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) XM40_00655 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) XM40_00660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) XM40_00665 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) XM40_00670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity XM40_00675 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) XM40_00680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) XM40_00685 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) XM40_00690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) XM40_00695 ENOG41082SA 50s ribosomal protein l29 XM40_00700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal XM40_00705 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) XM40_00715 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits XM40_00720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) XM40_00725 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) XM40_00730 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) XM40_00735 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) XM40_00740 ENOG4105VPB 50S ribosomal protein L30 XM40_00745 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) XM40_00750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) XM40_00755 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) XM40_00760 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) XM40_00765 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) XM40_00775 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits XM40_00780 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) XM40_00785 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) XM40_00790 ENOG4108ZT0 50S ribosomal protein l17 XM40_00795 ENOG4108JJB ABC transporter XM40_00800 ENOG4108JJB ABC transporter XM40_00805 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) XM40_00810 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) XM40_00815 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) XM40_00820 ENOG4108UJD 30S ribosomal protein S9 XM40_00825 ENOG4108I0C methyltransferase XM40_00845 ENOG4105D1F ATP-binding protein XM40_00860 ENOG4108NMV polysaccharide deacetylase XM40_00980 ENOG4108JPW Aminotransferase XM40_00995 ENOG4105CHH sulfate transporter XM40_01005 ENOG4108SA1 esterase XM40_01025 ENOG410874W AraC family transcriptional regulator XM40_01030 ENOG4105EHZ conserved protein UCP016719 XM40_01035 ENOG4105D17 glycoside hydrolase, family 3 domain protein XM40_01050 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate XM40_01060 ENOG4105EWC Purine nucleoside phosphorylase XM40_01090 ENOG4105EMN RNA polymerase sigma factor XM40_01100 ENOG4105C8B TIGR00159 family XM40_01105 ENOG4107U5W ybbr family XM40_01110 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) XM40_01135 ENOG41067MG lrgb family XM40_01145 ENOG41061AU MarR family Transcriptional regulator XM40_01160 ENOG4105BZU Histidine kinase XM40_01165 ENOG4105WH1 Two component transcriptional regulator luxr family XM40_01170 ENOG4105CJ1 ABC, transporter XM40_01195 ENOG4106DDH Sporulation-specific SASP protein XM40_01210 ENOG4107QTZ amino acid XM40_01215 ENOG4107VXM glycerophosphoryl diester phosphodiesterase XM40_01220 ENOG4105CXY transporter XM40_01255 ENOG4107SCQ Iron-containing alcohol dehydrogenase XM40_01260 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR XM40_01265 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase XM40_01270 ENOG4107ZTW SNARE associated Golgi XM40_01285 ENOG4105C72 UPF0176 protein XM40_01295 ENOG4105CM2 brancheD-chain amino acid aminotransferase XM40_01300 ENOG4108IQI permease XM40_01305 ENOG4108J5H Homocysteine s-methyltransferase XM40_01315 ENOG4105CSV Glutaminase XM40_01340 ENOG41076HS cation diffusion facilitator family transporter XM40_01345 ENOG4108TVJ Nitroreductase XM40_01350 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase XM40_01355 ENOG4108VGI doxx family XM40_01360 ENOG4105XXY Thioredoxin XM40_01375 ENOG4105DGI Alkaline phosphatase XM40_01380 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) XM40_01385 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) XM40_01390 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) XM40_01395 ENOG4107EPV Aminotransferase class V XM40_01400 ENOG4105C0R drug resistance transporter emrb qaca subfamily XM40_01405 ENOG4105J7D transcriptional regulator XM40_01410 ENOG4107RB3 L-asparaginase XM40_01415 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold XM40_01420 ENOG41060AI SEC-C motif XM40_01425 ENOG4107SET aldo keto reductase XM40_01455 ENOG4105H9W Short-chain dehydrogenase reductase Sdr XM40_01465 ENOG4105DSE periplasmic solute binding protein XM40_01470 ENOG4105DIK (ABC) transporter XM40_01480 ENOG4105DEN Luciferase family XM40_01485 ENOG4108N0M stress protein XM40_01490 ENOG4106FN3 tellurium resistance protein XM40_01495 ENOG4106FN3 tellurium resistance protein XM40_01500 ENOG4107TS3 membrane protein, TerC XM40_01505 ENOG4108TTB tellurium resistance protein XM40_01515 ENOG41079KZ Major Facilitator Superfamily XM40_01520 ENOG4108IJ7 Glycine betaine XM40_01525 ENOG4107SQ8 Glycine betaine XM40_01555 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) XM40_01585 ENOG4105EIG urea carboxylase-associated protein 1 XM40_01590 ENOG4107RA1 nh(3)-dependent nad( ) synthetase XM40_01600 ENOG4105I1F Resistance protein XM40_01605 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) XM40_01610 ENOG4105DJB Major Facilitator Superfamily XM40_01615 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) XM40_01620 ENOG4105I82 acetyl xylan esterase XM40_01625 ENOG410756H nucleotidyltransferase XM40_01635 ENOG4105C26 Dehydrogenase XM40_01640 ENOG4105CK7 Sodium proline symporter XM40_01645 ENOG4107YHD transcriptional regulator XM40_01650 ENOG4105CAY ferredoxin--nadp reductase XM40_01655 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) XM40_01660 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit XM40_01665 ENOG4108IFG nitrite reductase, (NAD(P)H) XM40_01670 ENOG4105CKI cobalamin synthesis protein XM40_01675 ENOG4105E2A Dehydrogenase XM40_01680 ENOG4105HHM rdd domain containing protein XM40_01705 ENOG41080HJ 6-phospho 3-hexuloisomerase XM40_01710 ENOG4108VA3 3-hexulose-6-phosphate synthase XM40_01715 ENOG4105KVH Transcriptional regulator XM40_01720 ENOG4105CEY Amp-dependent synthetase and ligase XM40_01740 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) XM40_01755 ENOG4105CDA abc transporter atp-binding protein XM40_01760 ENOG4105DRP amino acid AbC transporter XM40_01770 ENOG4106P55 Transcriptional regulator XM40_01775 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase XM40_01780 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) XM40_01785 ENOG41069ZX XM40_01790 ENOG41069ZX XM40_01795 ENOG4105DUX Transporter XM40_01810 ENOG4105E1K spore germination protein XM40_01825 ENOG4105CPU Monooxygenase XM40_01830 ENOG4108XSB acetyltransferase, (GNAT) family XM40_01835 ENOG4105EAB amino acid AbC transporter XM40_01840 ENOG4108HW4 amino acid AbC transporter XM40_01850 ENOG4105CH2 amidohydrolase XM40_01855 ENOG4108PGP mmge prpd family protein XM40_01865 ENOG4107WD8 ABC transporter, permease XM40_01870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XM40_01875 ENOG4105BZU Histidine kinase XM40_01890 ENOG4105CFH Aspartokinase XM40_01895 ENOG4105DHS permease protein XM40_01900 ENOG4105CM4 permease protein XM40_01905 ENOG4108IPW abc transporter atp-binding protein XM40_01920 ENOG4105R8C Transcriptional regulator XM40_01925 ENOG4108DBC nitroreductase XM40_01930 ENOG41067V3 Antibiotic biosynthesis monooxygenase XM40_01935 ENOG4105YVS arsR family transcriptional regulator XM40_01945 ENOG4108JPW Aminotransferase XM40_01950 ENOG4105C26 Dehydrogenase XM40_01960 ENOG4105H9W Short-chain dehydrogenase reductase Sdr XM40_01965 ENOG4105KTB nuclear export factor GLE1 XM40_01970 ENOG4108T5E Copper resistance protein XM40_01975 ENOG4108ZYE Transcriptional regulator XM40_01995 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase XM40_02010 ENOG4105E7W lamb ycsf family protein XM40_02015 ENOG4105C5A transporter XM40_02020 ENOG4105CFM UPF0317 protein XM40_02025 ENOG4105P4J Allophanate hydrolase, subunit 1 XM40_02035 ENOG4107258 Transcriptional regulator XM40_02040 ENOG4105XJB lipolytic protein G-D-S-L family XM40_02050 ENOG41061CK Antibiotic biosynthesis monooxygenase XM40_02055 ENOG4107RVG penicillin-binding protein XM40_02060 ENOG4107QM2 Aldo Keto reductase XM40_02065 ENOG4105ETD TRANSCRIPTIONal XM40_02075 ENOG4105CYX Short-chain dehydrogenase reductase Sdr XM40_02090 ENOG410606W general stress protein XM40_02100 ENOG4105VCH membrane XM40_02110 ENOG4105C9U ATP-dependent DNA helicase RecQ XM40_02125 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) XM40_02130 ENOG4107R8N Glycosyl transferase, family 2 XM40_02140 ENOG4105C0X amino acid XM40_02180 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) XM40_02195 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) XM40_02200 ENOG4105RXJ XM40_02205 ENOG4105KPY Small multidrug resistance protein XM40_02210 ENOG4105EU9 XM40_02215 ENOG4105QVS general stress protein XM40_02220 ENOG41082W1 Cupin 2, conserved barrel domain protein XM40_02235 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit XM40_02240 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism XM40_02245 ENOG4108MRH transcriptional regulatory protein XM40_02250 ENOG4107QJT sodium dicarboxylate symporter XM40_02255 ENOG4106F5Q Membrane XM40_02260 ENOG4105CJ1 ABC, transporter XM40_02275 ENOG4105FDT acyl-CoA dehydrogenase XM40_02290 ENOG4105SZ6 Thioredoxin XM40_02295 ENOG4105CPF Cell wall formation (By similarity) XM40_02300 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) XM40_02305 ENOG4105C1J atp-dependent rna helicase XM40_02310 ENOG410905X membrane-flanked domain protein XM40_02315 ENOG4105CKV Membrane XM40_02325 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) XM40_02330 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein XM40_02335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) XM40_02345 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) XM40_02350 ENOG4107MMM Anti-sigma-factor antagonist XM40_02355 ENOG4105FUA antagonist XM40_02360 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase XM40_02365 ENOG4107SGM protein serine threonine phosphatase XM40_02370 ENOG4105WN5 stage II sporulation protein XM40_02375 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) XM40_02385 ENOG41064BQ Phosphatase XM40_02395 ENOG410906U SprT-like XM40_02435 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein XM40_02445 ENOG4105CSH Transporter XM40_02460 ENOG4105K56 Transcriptional regulator XM40_02470 ENOG4108ZMQ domain protein XM40_02480 ENOG4108Z40 Transcriptional regulator XM40_02485 ENOG4108RYK Nad-dependent epimerase dehydratase XM40_02490 ENOG4105VEQ Cold shock protein XM40_02495 ENOG4105XTG Pfam:DUF156 XM40_02500 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase XM40_02505 ENOG4105VFE sira family XM40_02510 ENOG4107TPS domain protein XM40_02515 ENOG4105VFE sira family XM40_02520 ENOG41087NI Sulfite exporter TauE/SafE XM40_02540 ENOG4105IRW patatin-like phospholipase family protein XM40_02550 ENOG4107RCH Diaminopropionate ammonia-lyase XM40_02555 ENOG4108WYP Transcriptional regulator XM40_02560 ENOG4105KME endoribonuclease L-psp XM40_02565 ENOG4105C44 Serine transporter XM40_02570 ENOG4105CH2 amidohydrolase XM40_02575 ENOG4108MCI Transcriptional regulator, ARAC family XM40_02580 ENOG4105CE7 Amidase, hydantoinase carbamoylase family XM40_02585 ENOG4107U9B transcriptional regulator XM40_02590 ENOG4105DXI Major Facilitator superfamily XM40_02595 ENOG41062IR nudix hydrolase XM40_02610 ENOG4105DNP FAD linked oxidase domain protein XM40_02620 ENOG4105PGM cation diffusion facilitator family transporter XM40_02625 ENOG4105H3G oxidoreductase XM40_02640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) XM40_02665 ENOG4105DQ4 alcohol dehydrogenase XM40_02670 ENOG4105VUF Transcriptional regulator XM40_02680 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XM40_02695 ENOG4105EQ0 Major Facilitator superfamily XM40_02700 ENOG4108JGH Tetr family transcriptional regulator XM40_02715 ENOG4105E2A Dehydrogenase XM40_02720 ENOG4105PGS Spore coat protein XM40_02735 ENOG4105ENE Histidine kinase XM40_02740 ENOG4108VB1 regulatoR XM40_02745 ENOG4105EYF MMPL domain protein XM40_02765 ENOG4108JYZ YitT family XM40_02775 ENOG4105C2C drug resistance transporter, Bcr CflA XM40_02780 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) XM40_02800 ENOG41090E6 transcriptional regulator MERR family XM40_02815 ENOG4105F2W methyltransferase XM40_02820 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) XM40_02825 ENOG4105DRR Transcriptional regulator, GntR family XM40_02845 ENOG4105FQP Beta-lactamase XM40_02850 ENOG41090UD (LipO)protein XM40_02855 ENOG4108SUT Major Facilitator Superfamily XM40_02860 ENOG4108TZY GntR Family Transcriptional Regulator XM40_02865 ENOG4105JXH GntR family transcriptional regulator XM40_02870 ENOG4105DJ2 Major Facilitator Superfamily XM40_02890 ENOG4107QTZ amino acid XM40_02910 ENOG4107QNK )-transporter XM40_02950 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) XM40_02955 ENOG4105K8N protein family UPF0079, ATPase XM40_02960 ENOG41072GX Peptidase M22 Glycoprotease XM40_02965 ENOG410801F ribosomal-protein-alanine acetyltransferase XM40_02970 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) XM40_02975 ENOG4105C5H ABC transporter XM40_02980 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) XM40_02985 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) XM40_02990 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) XM40_02995 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) XM40_03005 ENOG4108TYN CAAX amino terminal protease family protein XM40_03010 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) XM40_03015 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) XM40_03020 ENOG4105ESF Peptidoglycan binding domain protein XM40_03035 ENOG4105PGZ NB-ARC domain XM40_03040 ENOG4105CPQ Dehydrogenase XM40_03045 ENOG4105CT4 transporter XM40_03060 ENOG41087YS Phage shock protein A XM40_03065 ENOG4105DQX Zinc finger domain XM40_03070 ENOG4108WV1 Pfam:DUF477 XM40_03080 ENOG4105EXC Acyl-transferase XM40_03085 ENOG4108P49 AntiSigma factor XM40_03090 ENOG4105JVQ RNA Polymerase XM40_03120 ENOG4107STQ Multicopper oxidase XM40_03125 ENOG4105C85 amino acid XM40_03130 ENOG4105C7R Atpase associated with various cellular activities aaa_3 XM40_03145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) XM40_03160 ENOG4105C7N Xanthine uracil vitamin C permease XM40_03180 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) XM40_03185 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit XM40_03190 ENOG4105C83 adenylosuccinate lyase XM40_03195 ENOG4105C8V SAICAR synthetase XM40_03200 ENOG4105VR9 phosphoribosylformylglycinamidine synthase XM40_03205 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I XM40_03210 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii XM40_03220 ENOG4105CXB phosphoribosylaminoimidazole synthetase XM40_03225 ENOG4108V3E phosphoribosylglycinamide formyltransferase XM40_03230 ENOG4105DC1 bifunctional purine biosynthesis protein purh XM40_03235 ENOG4105C12 Phosphoribosylglycinamide synthetase XM40_03250 ENOG4108R5T secreted protein XM40_03255 ENOG4105KGF protein, YerC YecD XM40_03260 ENOG4105CBC glutamate synthase XM40_03275 ENOG4105C4R Atp-dependent dna helicase XM40_03280 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) XM40_03290 ENOG4105CRN Aminoglycoside phosphotransferase XM40_03295 ENOG4105KT7 mgtC SapB transporter XM40_03300 ENOG4105CK7 Sodium proline symporter XM40_03305 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) XM40_03310 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) XM40_03315 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) XM40_03320 ENOG4108IG5 Transcriptional regulator XM40_03330 ENOG4105CBD Diacylglycerol kinase XM40_03335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) XM40_03345 ENOG4105CJ1 ABC, transporter XM40_03380 ENOG4105CDY transcriptional regulatory protein XM40_03390 ENOG41075D4 Aminoglycoside 6-adenylyltransferase XM40_03405 ENOG4105WEF catalase XM40_03410 ENOG4105M18 -acetyltransferase XM40_03420 ENOG4105H67 Protein of unknown function (DUF421) XM40_03425 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) XM40_03430 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily XM40_03445 ENOG4106I4J membrane XM40_03455 ENOG4108R1P XM40_03460 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) XM40_03470 ENOG4105E0M Sulfatase XM40_03475 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase XM40_03485 ENOG41090R9 glycosyltransferase XM40_03490 ENOG4107R51 Glycosyl transferase, family 2 XM40_03495 ENOG41090R9 glycosyltransferase XM40_03500 ENOG4105EU0 Major facilitator Superfamily XM40_03505 ENOG4105CUB amino acid XM40_03510 ENOG4105C26 Dehydrogenase XM40_03515 ENOG4105FKZ Methyl-accepting chemotaxis XM40_03520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr XM40_03525 ENOG4107TVC Glycosyl transferase, family 2 XM40_03530 ENOG4105C5H ABC transporter XM40_03535 ENOG4107SWG transcriptional regulator MERR family XM40_03540 ENOG4105DXB Major Facilitator superfamily XM40_03545 ENOG4105C5H ABC transporter XM40_03550 ENOG4105FDU atp-dependent rna helicase XM40_03560 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein XM40_03575 ENOG4108J20 pectate lyase XM40_03580 ENOG4107QPK )-transporter XM40_03605 ENOG4108VAC response regulator XM40_03615 ENOG4108Z6X (sortase) family XM40_03625 ENOG4108MRH transcriptional regulatory protein XM40_03650 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) XM40_03655 ENOG4108RPX mosc domain containing protein XM40_03665 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) XM40_03705 ENOG4105C5Y PTS System XM40_03710 ENOG4105CG3 alpha amylase, catalytic region XM40_03715 ENOG4107414 GntR family transcriptional regulator XM40_03720 ENOG4108RCM Nitroreductase XM40_03735 ENOG4105CGH 5'-nucleotidase XM40_03740 ENOG4107RKG DJ-1/PfpI family XM40_03745 ENOG4105ETE Transcriptional regulator (LacI family XM40_03750 ENOG4105E2X shikimate dehydrogenase XM40_03755 ENOG4105FF2 Type I DHQase XM40_03770 ENOG4105KJF protein tyrosine phosphatase XM40_03780 ENOG4107U9T Pfam:Ribonuclease_BN XM40_03785 ENOG4108ISG Major Facilitator XM40_03790 ENOG4105UPD Calcium Proton XM40_03800 ENOG4105D8X mechanosensitive ion channel XM40_03820 ENOG4106KE4 Dehydrogenase XM40_03830 ENOG4105D7N magnesium and cobalt transport protein CorA XM40_03840 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) XM40_03860 ENOG4107RUY (E1 component), alpha subunit XM40_03870 ENOG4107QKR Dehydrogenase XM40_03880 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family XM40_03890 ENOG4105F8D glycoside hydrolase family 4 XM40_03895 ENOG4108Q3X Transcriptional regulator XM40_03900 ENOG4105CI1 PTS System XM40_03905 ENOG4105BZ1 (ABC) transporter XM40_03910 ENOG4105BZ1 (ABC) transporter XM40_03920 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase XM40_03925 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) XM40_03930 ENOG4105U3E Transcriptional regulator XM40_03935 ENOG4105DYS nad(p)h dehydrogenase (quinone) XM40_03940 ENOG4105H93 Acyltransferase family XM40_03955 ENOG4108YYS metal-dependent hydrolase (By similarity) XM40_03960 ENOG4105C0R drug resistance transporter emrb qaca subfamily XM40_03965 ENOG410834F Transcriptional regulator XM40_03975 ENOG4105JAB phenazine biosynthesis protein, phzf family XM40_03980 ENOG4107Y03 Nitroreductase XM40_03990 ENOG4105ECP epimerase XM40_03995 ENOG410902V Modulates RecA activity (By similarity) XM40_04005 ENOG4105F27 Major Facilitator XM40_04015 ENOG4108TCS Glutamyl endopeptidase XM40_04035 ENOG4106AKJ XM40_04040 ENOG4105D74 hydrolase XM40_04045 ENOG4105CKK Glycosyl transferase, family 2 XM40_04050 ENOG4105EJV Membrane XM40_04055 ENOG41067AE Membrane-bound metal-dependent hydrolase XM40_04060 ENOG4105CEN a g-specific adenine glycosylase XM40_04065 ENOG4106BXE XM40_04070 ENOG4105CAN Short-chain dehydrogenase reductase Sdr XM40_04090 ENOG4105BZ1 (ABC) transporter XM40_04095 ENOG4107NBY Membrane XM40_04100 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase XM40_04105 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XM40_04110 ENOG4105G5W regulator Fur family XM40_04115 ENOG4105TUA UPF0295 protein XM40_04225 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) XM40_04230 ENOG4105DNP FAD linked oxidase domain protein XM40_04240 ENOG4105DEF Extracellular solute-binding protein, family 5 XM40_04250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XM40_04255 ENOG4105C3U ABC transporter XM40_04260 ENOG4108JQ7 (ABC) transporter XM40_04275 ENOG4105E2Y ABC, transporter XM40_04280 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein XM40_04285 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component XM40_04295 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) XM40_04300 ENOG4107D63 XM40_04305 ENOG4105VZ8 Transcriptional regulator XM40_04320 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) XM40_04330 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) XM40_04350 ENOG4105CYN Serine protein kinase XM40_04360 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes XM40_04365 ENOG4105CW7 secretion protein, HlyD family XM40_04370 ENOG4105C0R drug resistance transporter emrb qaca subfamily XM40_04375 ENOG4105CS1 NAD(P)H quinone oxidoreductase XM40_04390 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family XM40_04395 ENOG4105CZV ABC transporter XM40_04400 ENOG4105CJ1 ABC, transporter XM40_04405 ENOG4108TU7 Inherit from COG: (ABC) transporter XM40_04410 ENOG4105VEQ Cold shock protein XM40_04420 ENOG4105BZU Histidine kinase XM40_04460 ENOG4108YBP pseudouridine synthase XM40_04470 ENOG41080XP Cbs domain XM40_04475 ENOG4107YBY Hydrolase XM40_04480 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase XM40_04485 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) XM40_04490 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator XM40_04500 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) XM40_04505 ENOG4105C6V Glycerol-3-phosphate dehydrogenase XM40_04555 ENOG4105ED1 spovr family XM40_04560 ENOG4105G6Z alkaline phosphatase XM40_04575 ENOG4105BZN citrate synthase XM40_04580 ENOG4105CYX Short-chain dehydrogenase reductase Sdr XM40_04585 ENOG4105CUB amino acid XM40_04590 ENOG4105C8J )-transporter XM40_04600 ENOG4105J37 XM40_04605 ENOG4108AEY RNA polymerase sigma factor XM40_04610 ENOG4105F6E Acyl-transferase XM40_04615 ENOG4105C37 (CBS) domain XM40_04625 ENOG4105CHM Aminotransferase XM40_04630 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase XM40_04635 ENOG4105C37 (CBS) domain XM40_04645 ENOG4105WMR Protein CrcB homolog XM40_04650 ENOG4108QXE glycerophosphoryl diester phosphodiesterase XM40_04655 ENOG4105D64 Mechanosensitive ion channel XM40_04660 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) XM40_04665 ENOG4107VMI polysaccharide deacetylase XM40_04670 ENOG4105F0I Aminotransferase XM40_04675 ENOG4105W1N transcriptional regulator XM40_04680 ENOG4105IIP Membrane XM40_04690 ENOG4105BZ1 (ABC) transporter XM40_04695 ENOG4105BZ1 (ABC) transporter XM40_04715 ENOG410839P XM40_04725 ENOG4106MP8 UPF0754 membrane protein XM40_04730 ENOG4105WZB UPF0342 protein XM40_04735 ENOG4105F1N DNA alkylation repair XM40_04745 ENOG4105D4P Coproporphyrinogen iii oxidase XM40_04755 ENOG4107S91 Sodium hydrogen exchanger XM40_04760 ENOG4105NCW Trka-c domain protein XM40_04770 ENOG4105CGU Enoyl-CoA hydratase XM40_04780 ENOG4108IUX (ABC) transporter XM40_04785 ENOG4105RHA ABC transporter, permease XM40_04790 ENOG4107VRP DNA repair exonuclease XM40_04795 ENOG4106D4I domain protein XM40_04800 ENOG4105EQI Metal Dependent Phosphohydrolase XM40_04810 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) XM40_04855 ENOG4105NBU tryptophan transport protein XM40_04860 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) XM40_04865 ENOG4105K59 histidine triad (HIT) protein XM40_04895 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation XM40_04900 ENOG4105BZ4 penicillin-binding protein XM40_04905 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) XM40_04910 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) XM40_04915 ENOG4105C1Q protoporphyrinogen oxidase XM40_04925 ENOG4105ECB domain protein XM40_04940 ENOG4105DER m42 family XM40_04950 ENOG4108RQ5 Beta-lactamase domain-containing protein XM40_04955 ENOG4105DF9 Lipoate-protein, ligase XM40_04965 ENOG4105CEY Amp-dependent synthetase and ligase XM40_04975 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 XM40_04995 ENOG4107TB6 phosphoglycerate mutase XM40_05005 ENOG4107F3J Amp-dependent synthetase and ligase XM40_05010 ENOG4107ZYJ bioY protein XM40_05015 ENOG4106YBV Methyl-accepting chemotaxis XM40_05035 ENOG4105XVF Competence transcription factor XM40_05045 ENOG4108ZMX Domain of unknown function (DU1801) XM40_05055 ENOG4105X3H Excalibur domain protein XM40_05060 ENOG4105K8R UPF0145 protein XM40_05065 ENOG4105E1V na solute symporter XM40_05070 ENOG4106CAD Protein of unknown function (DUF3311) XM40_05075 ENOG41060YP XM40_05090 ENOG4107SCK Monooxygenase XM40_05095 ENOG4108INS Transcriptional regulator XM40_05100 ENOG4108KK1 membrane protein AbrB duplication XM40_05110 ENOG4108IG5 Transcriptional regulator XM40_05120 ENOG4108QY0 Membrane XM40_05125 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination XM40_05130 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation XM40_05140 ENOG4105EYH Exonuclease XM40_05185 ENOG4105ERH Fumarylacetoacetate hydrolase XM40_05205 ENOG4105CAQ asparagine synthetase XM40_05215 ENOG4105UQX Mate efflux family protein XM40_05220 ENOG4106HBX Transcriptional Regulator AraC Family XM40_05225 ENOG4105ETE Transcriptional regulator (LacI family XM40_05230 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) XM40_05235 ENOG4105SF0 DinB family XM40_05240 ENOG4105MYW Pentapeptide repeat protein XM40_05245 ENOG4105MA6 gCN5-related N-acetyltransferase XM40_05255 ENOG4108VPT UPF0234 protein XM40_05260 ENOG4105QNR S1 RNA binding domain protein XM40_05265 ENOG4105DIH basic membrane XM40_05270 ENOG4105C8Q Methyl-accepting chemotaxis XM40_05275 ENOG4105EPR degv family XM40_05280 ENOG4107AYK membrAne XM40_05290 ENOG41073B9 XM40_05295 ENOG4108KP7 hydrolase XM40_05300 ENOG4108MXZ Esterase XM40_05305 ENOG4105VG1 fes assembly suf system protein XM40_05310 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) XM40_05315 ENOG4105IQ5 FAD linked oxidase domain protein XM40_05325 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase XM40_05335 ENOG4105CAS nag kinase XM40_05340 ENOG4105C8Y Acetylornithine aminotransferase XM40_05345 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain XM40_05355 ENOG4105DBV ornithine carbamoyltransferase XM40_05385 ENOG4107RMD Basic membrane lipoprotein XM40_05400 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) XM40_05405 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) XM40_05415 ENOG4105C3U ABC transporter XM40_05420 ENOG4108JQ7 (ABC) transporter XM40_05435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XM40_05455 ENOG4105C31 Tryptophanyl-tRNA synthetase XM40_05460 ENOG4108J59 Extracellular solute-binding protein, family 5 XM40_05465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component XM40_05470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XM40_05480 ENOG4108JQ7 (ABC) transporter XM40_05495 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) XM40_05500 ENOG4108ZCF integral membrane protein XM40_05505 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis XM40_05515 ENOG4105DPN Oligoendopeptidase f XM40_05525 ENOG4105T58 Dithiol-disulfide isomerase XM40_05530 ENOG4108Z18 K06886 hemoglobin XM40_05535 ENOG4105E4C Lytic transglycosylase catalytic XM40_05540 ENOG4105MIX Adenylate cyclase XM40_05555 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) XM40_05560 ENOG4105EMS pseudouridine synthase XM40_05565 ENOG4107S1Q Phosphatase XM40_05575 ENOG4105ETU transcriptional activator (TenA XM40_05580 ENOG4108VEU Thiamine monophosphate synthase XM40_05600 ENOG4105D06 uba thif-type nad fad binding protein XM40_05605 ENOG4105DWF phosphomethylpyrimidine kinase XM40_05610 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH XM40_05615 ENOG4107A88 XM40_05665 ENOG4105ENA helicase XM40_05685 ENOG4105CJ1 ABC, transporter XM40_05700 ENOG4108ZMI UPF0477 protein XM40_05710 ENOG4105C28 cystathionine XM40_05715 ENOG4105C28 cystathionine XM40_05730 ENOG4106BHF XM40_05740 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase XM40_05770 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase XM40_05775 ENOG4105CMR udp-glucose 4-epimerase XM40_05780 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) XM40_05785 ENOG4105CK1 PTS System XM40_05790 ENOG4105VCP PTS System XM40_05800 ENOG4105E98 transcriptional regulator DeoR family XM40_05820 ENOG4105KT7 mgtC SapB transporter XM40_05835 ENOG4108IEG Formate dehydrogenase Alpha subunit XM40_05845 ENOG4106A3M Cytochrome p-450 XM40_05850 ENOG41087PP glycosyltransferase MGT family XM40_05860 ENOG4105EXQ uroporphyrinogen iii synthase hem4 XM40_05865 ENOG4105C4B ABC transporter, permease XM40_05870 ENOG4108IXI (ABC) transporter XM40_05880 ENOG4105Q95 Cupin 2, conserved barrel domain protein XM40_05895 ENOG4105D2H Uronic isomerase XM40_05900 ENOG4105CT4 transporter XM40_05905 ENOG4107KJX Transcriptional regulator XM40_05915 ENOG4105CTX dehydratase XM40_05920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XM40_05925 ENOG4105F3H Histidine kinase XM40_05945 ENOG4105BZU Histidine kinase XM40_05950 ENOG4105WH1 Two component transcriptional regulator luxr family XM40_05965 ENOG4108JJA ABC, transporter XM40_05975 ENOG4107TSN permease XM40_05995 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XM40_06000 ENOG4105KWG Pfam:DUF1696 XM40_06005 ENOG4105K7W phage-related replication protein XM40_06010 ENOG410635T phage-like element pbsx protein XM40_06050 ENOG4108TFU terminase (Small subunit) XM40_06055 ENOG4105IG6 Phage terminase, large subunit XM40_06060 ENOG4108MDF Phage Portal Protein XM40_06085 ENOG41060SN XM40_06100 ENOG4105PQS phage protein XM40_06105 ENOG4105FR7 XkdM protein, phage-like element PBSX XM40_06110 ENOG4105MTC XkdN-like protein XM40_06115 ENOG4108FKH Transglycosylase SLT domain XM40_06115 ENOG4108FKH Transglycosylase SLT domain XM40_06115 ENOG4108FKH Transglycosylase SLT domain XM40_06120 ENOG4108WZM domain protein XM40_06125 ENOG4105X7F XM40_06135 ENOG4105MFU Protein of unknown function (DUF2634) XM40_06140 ENOG41066EA baseplate J family protein XM40_06145 ENOG410906S phage-like element pbsx protein xkdt XM40_06155 ENOG41068G1 XM40_06185 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XM40_06200 ENOG4105CJ3 phosphate transporter XM40_06205 ENOG4107GRR phosphate transport regulator XM40_06210 ENOG4107R7I amino acid XM40_06220 ENOG4105EDW glycosyl transferase, family 39 XM40_06225 ENOG4105CKK Glycosyl transferase, family 2 XM40_06230 ENOG4105C0H protease XM40_06240 ENOG4108ME1 Peptidase M55 D-aminopeptidase XM40_06245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component XM40_06250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XM40_06255 ENOG4105C3U ABC transporter XM40_06265 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A XM40_06270 ENOG4105DTQ mandelate racemase muconate lactonizing XM40_06275 ENOG4107SN7 NLP P60 protein XM40_06280 ENOG4108JQ7 (ABC) transporter XM40_06285 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) XM40_06290 ENOG4107TUM Amidinotransferase XM40_06295 ENOG4108S4H thioesterase Superfamily protein XM40_06300 ENOG4108428 Inherit from COG: -acetyltransferase XM40_06310 ENOG41080TC multidrug resistance protein XM40_06315 ENOG4105CIY formyltetrahydrofolate deformylase XM40_06320 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) XM40_06335 ENOG4105K56 Transcriptional regulator XM40_06340 ENOG4108ZHJ Organic hydroperoxide resistance protein XM40_06355 ENOG4107TVC Glycosyl transferase, family 2 XM40_06365 ENOG4105D8G Major Facilitator superfamily XM40_06370 ENOG4108Y4K DNA-binding transcriptional activator XM40_06375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) XM40_06380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin XM40_06390 ENOG4108W7F transporter, permease XM40_06395 ENOG4108JJB ABC transporter XM40_06400 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein XM40_06405 ENOG4105VRS hydrolase family 18 XM40_06410 ENOG4105CJW magnesium transporter XM40_06415 ENOG4105V75 Transcriptional regulator XM40_06435 ENOG4105DQE DNA ligase XM40_06440 ENOG4105FDF Could be involved in DNA repair (By similarity) XM40_06450 ENOG4107T5V SNARE associated Golgi XM40_06455 ENOG4107TS3 membrane protein, TerC XM40_06460 ENOG4108WZW RNA polymerase sigma XM40_06470 ENOG410681C small acid-soluble spore protein XM40_06480 ENOG4105D0M Protease HtpX homolog XM40_06490 ENOG410900G Protein of unknown function (DUF421) XM40_06495 ENOG4108TGC Acyltransferase XM40_06500 ENOG4105BZU Histidine kinase XM40_06505 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) XM40_06510 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) XM40_06520 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase XM40_06530 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate XM40_06535 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) XM40_06540 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) XM40_06545 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) XM40_06555 ENOG4105BZU Histidine kinase XM40_06560 ENOG41090MY MarR family Transcriptional regulator XM40_06565 ENOG4105ER2 Ompa motb domain protein XM40_06570 ENOG4105E14 MotA TolQ exbB proton channel XM40_06585 ENOG4108K88 Membrane XM40_06595 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) XM40_06600 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase XM40_06605 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) XM40_06610 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) XM40_06660 ENOG4105F0V Cell wall hydrolase XM40_06675 ENOG4105C59 p-type ATPase XM40_06680 ENOG4105DC7 peptidase M24 XM40_06690 ENOG4105CID antiterminator XM40_06700 ENOG4105KRI phosphocarrier protein (HPr XM40_06705 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) XM40_06715 ENOG4105F6S Spore photoproduct lyase XM40_06720 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer XM40_06725 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase XM40_06740 ENOG4105K4I Scp-like extracellular XM40_06750 ENOG4105BZU Histidine kinase XM40_06755 ENOG4105CHM Aminotransferase XM40_06760 ENOG4107R88 Chemotaxis protein (CheV) XM40_06765 ENOG4105UIN XM40_06775 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein XM40_06785 ENOG4105K6S Short-chain dehydrogenase reductase Sdr XM40_06795 ENOG4105EPM Diguanylate phosphodiesterase XM40_06800 ENOG4107IN1 Protein of unknown function (DUF1797) XM40_06805 ENOG4108XRC Protein of unknown function (DUF458) XM40_06835 ENOG4105NQC Flavodoxin XM40_06855 ENOG4105D8X mechanosensitive ion channel XM40_06860 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XM40_06875 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) XM40_06880 ENOG4105D06 uba thif-type nad fad binding protein XM40_06885 ENOG4105CVM Molybdenum cofactor synthesis domain protein XM40_06890 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein XM40_06895 ENOG4108ZAF Molybdopterin XM40_06900 ENOG41067WU Molybdopterin converting factor (Subunit 1) XM40_06910 ENOG4107X8C Efflux transporter RND family MFP subunit XM40_06915 ENOG4105C19 ABC transporter XM40_06920 ENOG4107RBB ABC transporter, permease XM40_06925 ENOG4105E98 transcriptional regulator DeoR family XM40_06930 ENOG4105DE4 1-phosphofructokinase XM40_06935 ENOG4105DM4 PTS System XM40_06950 ENOG4105C5H ABC transporter XM40_06955 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) XM40_06980 ENOG4105BZU Histidine kinase XM40_06990 ENOG4107ZYR domain protein XM40_06995 ENOG4105CPN adenine deaminase XM40_07000 ENOG4105CN5 Metallo-Beta-Lactamase XM40_07005 ENOG4106148 UPF0356 protein XM40_07010 ENOG4108X4Q Hydrolase XM40_07015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) XM40_07030 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase XM40_07035 ENOG4105C0W non-ribosomal peptide synthetase XM40_07040 ENOG4107SQU synthase XM40_07045 ENOG4105C0W non-ribosomal peptide synthetase XM40_07050 ENOG4107SQU synthase XM40_07055 ENOG4107SQU synthase XM40_07060 ENOG4107SQU synthase XM40_07065 ENOG4105C0W non-ribosomal peptide synthetase XM40_07070 ENOG4105FQP Beta-lactamase XM40_07080 ENOG4105CPP Dehydrogenase, E1 component XM40_07085 ENOG4105C7S Dehydrogenase XM40_07090 ENOG4107QN2 dihydrolipoyl dehydrogenase XM40_07105 ENOG4105CXN decarboxylase XM40_07110 ENOG4105WBI UPF0223 protein XM40_07125 ENOG4105ECY inositol monophosphatase XM40_07135 ENOG4105D4Y metalloprotease XM40_07170 ENOG4105CI3 gtp-binding protein typa XM40_07175 ENOG4105QA2 XM40_07190 ENOG4108IAB Phoh family XM40_07200 ENOG4105CSV Glutaminase XM40_07210 ENOG4105CNI cell division protein FtsW XM40_07215 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) XM40_07225 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) XM40_07235 ENOG4105BZ9 Cytochrome C oxidase, subunit I XM40_07240 ENOG4105CCU oxidase (Subunit III) XM40_07245 ENOG41064X9 cytochrome C oxidase subunit IV XM40_07260 ENOG41080XQ Signal transduction protein with cbs domains XM40_07265 ENOG4106UY4 Inherit from COG: Scp-like extracellular XM40_07295 ENOG4106H78 methyltransferase XM40_07300 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) XM40_07305 ENOG4105H20 Sporulation integral membrane protein YlbJ XM40_07310 ENOG4105D78 K07001 NTE family protein XM40_07315 ENOG41063PX domain protein XM40_07320 ENOG4105CDE UPF0348 protein XM40_07325 ENOG4105KNH Nucleic acid-binding protein XM40_07350 ENOG4108V6E Cell division protein mraZ XM40_07355 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) XM40_07365 ENOG4105CJN penicillin-binding protein XM40_07370 ENOG4105CJN penicillin-binding protein XM40_07375 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) XM40_07380 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) XM40_07385 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) XM40_07390 ENOG4105CNI cell division protein FtsW XM40_07395 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) XM40_07400 ENOG4105D4A Cell wall formation (By similarity) XM40_07405 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) XM40_07410 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) XM40_07415 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) XM40_07425 ENOG4105FFI sigma-e processing peptidase spoiiga XM40_07430 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_07440 ENOG4105DKW ABC transporter XM40_07450 ENOG4105WR5 sporulation protein, YlmC YmxH family XM40_07455 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase XM40_07460 ENOG4105DFA alanine racemase domain protein XM40_07465 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) XM40_07470 ENOG41067XK integral membrane protein XM40_07475 ENOG4105DBK s4 domain protein XM40_07490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) XM40_07500 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) XM40_07505 ENOG4105C34 Pseudouridine synthase XM40_07510 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) XM40_07520 ENOG4105CXT aspartate transcarbamylase XM40_07530 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain XM40_07535 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain XM40_07540 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) XM40_07545 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) XM40_07550 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) XM40_07555 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) XM40_07570 ENOG4107RIQ Sulfate adenylate transferase XM40_07580 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) XM40_07585 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein XM40_07590 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein XM40_07595 ENOG4105F23 Fibronectin-binding protein XM40_07605 ENOG4105DSJ YicC domain protein XM40_07610 ENOG4105KC4 UPF0296 protein XM40_07615 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) XM40_07625 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase XM40_07630 ENOG4105C25 Primosomal protein n' XM40_07635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) XM40_07640 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) XM40_07645 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B XM40_07650 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs XM40_07655 ENOG4108ZF3 Phosphatase XM40_07660 ENOG4105D9P serine threonine protein kinase XM40_07665 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) XM40_07670 ENOG4105DJV ribulose-phosphate 3-epimerase XM40_07675 ENOG4105FJ0 thiamine XM40_07685 ENOG4105VB9 50S ribosomal protein l28 XM40_07690 ENOG4108ZAA Alkaline-shock protein XM40_07695 ENOG4105DP4 dak2 domain fusion protein ylov XM40_07705 ENOG4105EJQ L-serine dehydratase XM40_07710 ENOG4105CB5 ATP-dependent DNA helicase recG XM40_07715 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) XM40_07720 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) XM40_07725 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase XM40_07730 ENOG4105CHR reductase XM40_07735 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) XM40_07740 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) XM40_07745 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) XM40_07750 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) XM40_07760 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) XM40_07770 ENOG4105K5M 30s ribosomal protein S16 XM40_07775 ENOG4108BW8 UPF0109 protein XM40_07790 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) XM40_07795 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) XM40_07800 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) XM40_07805 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) XM40_07815 ENOG4105VM1 flagellar XM40_07820 ENOG4105CMV Succinyl-CoA synthetase subunit beta XM40_07825 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha XM40_07830 ENOG4105C79 DNA protecting protein DprA XM40_07835 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) XM40_07840 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) XM40_07845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) XM40_07850 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) XM40_07855 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) XM40_07865 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) XM40_07870 ENOG4108ZC9 flagellar basal-body rod protein flgc XM40_07875 ENOG4105VQ0 flagellar hook-basal body complex protein fliE XM40_07880 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) XM40_07885 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) XM40_07900 ENOG4106YF4 Flagellar biosynthesis chaperone XM40_07910 ENOG410696Y Flagellar hook-length control protein XM40_07915 ENOG410822I Flagellar hook capping protein XM40_07920 ENOG4108JQA flagellar XM40_07925 ENOG41068WV flagellar FlbD family protein XM40_07935 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) XM40_07940 ENOG4105DD5 Flagellar motor switch protein XM40_07945 ENOG4107YTP response regulator receiver protein XM40_07955 ENOG4105CN7 Flagellar biosynthetic protein FliP XM40_07960 ENOG4105VS8 Flagellar biosynthetic protein fliq XM40_07965 ENOG4105D19 Role in flagellar biosynthesis (By similarity) XM40_07970 ENOG4105D00 flagellar biosynthetic protein flhB XM40_07975 ENOG4105D7B Flagellar biosynthesis protein flha XM40_07980 ENOG4105FZW flagellar biosynthesis regulator FlhF XM40_07990 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) XM40_07995 ENOG4105CBS Chea signal transduction histidine kinase XM40_08000 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis XM40_08010 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) XM40_08015 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_08025 ENOG4105CE9 30S ribosomal protein S2 XM40_08035 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) XM40_08040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) XM40_08045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) XM40_08050 ENOG4105KNE Phosphatidate cytidylyltransferase XM40_08060 ENOG4105DZP Membrane-associated zinc metalloprotease XM40_08065 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) XM40_08070 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) XM40_08075 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) XM40_08080 ENOG4105CHV Transcription elongation factor NusA XM40_08085 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination XM40_08090 ENOG4105VHM ribosomal protein XM40_08095 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) XM40_08100 ENOG4105W7A Protein of unknown function (DUF503) XM40_08105 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) XM40_08110 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) XM40_08115 ENOG4105DTN riboflavin biosynthesis protein ribF XM40_08120 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) XM40_08125 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) XM40_08135 ENOG4105C1V Peptidase, M16 XM40_08145 ENOG4105E35 Dipicolinate synthase subunit A XM40_08150 ENOG4108S0H Dipicolinic acid synthetase, b subunit XM40_08155 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) XM40_08165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) XM40_08175 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit XM40_08185 ENOG4105CNU cell division protein FtsK XM40_08190 ENOG4105FDP GntR family transcriptional regulator XM40_08205 ENOG4105EYF MMPL domain protein XM40_08220 ENOG4108RKS Short-chain dehydrogenase reductase Sdr XM40_08225 ENOG4105XZV Protein of unknown function (DUF3243) XM40_08240 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase XM40_08245 ENOG4105CEV competence damage-inducible protein XM40_08250 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) XM40_08255 ENOG4108A04 Beta-lactamase XM40_08265 ENOG4105D48 metallophosphoesterase XM40_08270 ENOG4105MCT stage V sporulation protein S XM40_08275 ENOG4105CPQ Dehydrogenase XM40_08280 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) XM40_08285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) XM40_08305 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) XM40_08310 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) XM40_08320 ENOG4108IMY Transcriptional regulator XM40_08405 ENOG410682Q Phage transcriptional regulator, ArpU XM40_08505 ENOG4108FKH Transglycosylase SLT domain XM40_08515 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj XM40_08525 ENOG41068G1 XM40_08550 ENOG4108151 Beta-lactamase domain protein XM40_08555 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase XM40_08560 ENOG4108JA1 polyketide synthase XM40_08565 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase XM40_08570 ENOG41062T2 Acyl carrier protein XM40_08575 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase XM40_08580 ENOG4108MGH Enoyl-CoA hydratase XM40_08585 ENOG4108KQ6 Enoyl-CoA hydratase XM40_08590 ENOG4105C0W non-ribosomal peptide synthetase XM40_08595 ENOG4107SQU synthase XM40_08605 ENOG4105C0W non-ribosomal peptide synthetase XM40_08615 ENOG4106A3M Cytochrome p-450 XM40_08620 ENOG4105WFK nuclease XM40_08625 ENOG4105XPP Protein of unknown function (DUF1275) XM40_08635 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin XM40_08645 ENOG4105K7W phage-related replication protein XM40_08650 ENOG4108X3M OsmC Ohr family protein XM40_08675 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) XM40_08700 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) XM40_08705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) XM40_08710 ENOG4105U6W MutT NUDIX family protein XM40_08725 ENOG4106F1P AAA ATPase, central domain protein XM40_08730 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) XM40_08735 ENOG4105CXI aluminum resistance protein XM40_08740 ENOG4105KV4 Transcriptional regulator XM40_08745 ENOG4105C5F glutamine synthetase XM40_08755 ENOG4105CT4 transporter XM40_08760 ENOG4105DSG hydrolase family 43 XM40_08770 ENOG4105C93 Xylose Isomerase XM40_08775 ENOG4105CMG Carbohydrate kinase XM40_08780 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) XM40_08800 ENOG4105DQ4 alcohol dehydrogenase XM40_08830 ENOG4108M1A Chitin-binding protein XM40_08850 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) XM40_08855 ENOG4105K7W phage-related replication protein XM40_08875 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) XM40_08885 ENOG4108SVB resolvase XM40_08890 ENOG4105VPS UPF0291 protein XM40_08895 ENOG4105CV1 Transketolase (EC 2.2.1.1) XM40_08905 ENOG4105VXM UPF0154 protein XM40_08915 ENOG4107QIV Cytochrome c biogenesis protein XM40_08950 ENOG4108I0Z Aconitate hydratase XM40_08955 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XM40_08970 ENOG41067CD Small, acid-soluble spore protein Tlp XM40_08980 ENOG4105MI2 XM40_08985 ENOG4105W8X HesB YadR YfhF-family protein XM40_08990 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) XM40_08995 ENOG4105K4P CoA-binding domain protein XM40_09000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) XM40_09025 ENOG4105CPQ Dehydrogenase XM40_09030 ENOG4108UHU Aldolase XM40_09035 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) XM40_09040 ENOG4105DMW Dehydrogenase reductase XM40_09050 ENOG4108I5G Major Facilitator superfamily XM40_09065 ENOG4105FVX XM40_09105 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XM40_09115 ENOG4107SYN Glycosyl hydrolases family 43 XM40_09140 ENOG4105DTD Dehydrogenase XM40_09145 ENOG4108IIH CoA-transferase subunit B XM40_09150 ENOG4105D6N CoA-transferase, subunit a XM40_09155 ENOG4105CY2 Citrate transporter XM40_09160 ENOG4106A3M Cytochrome p-450 XM40_09165 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) XM40_09170 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) XM40_09175 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) XM40_09180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) XM40_09185 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) XM40_09195 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase XM40_09200 ENOG4107T5V SNARE associated Golgi XM40_09205 ENOG4107QX3 carboxylase XM40_09210 ENOG4105E39 Enoyl-CoA hydratase XM40_09215 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase XM40_09220 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit XM40_09225 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase XM40_09230 ENOG4105CEY Amp-dependent synthetase and ligase XM40_09235 ENOG4105C1G acyl-Coa dehydrogenase XM40_09240 ENOG4105F32 YngK protein XM40_09245 ENOG4106U2H Protein of unknown function (DUF1360) XM40_09255 ENOG4105CEY Amp-dependent synthetase and ligase XM40_09310 ENOG4106ANW SMI1_KNR4 XM40_09315 ENOG4106BHF XM40_09390 ENOG4105C0W non-ribosomal peptide synthetase XM40_09400 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family XM40_09405 ENOG4108N2V aldose 1-epimerase XM40_09410 ENOG4107QJQ Mate efflux family protein XM40_09435 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) XM40_09440 ENOG4108RWP Major Facilitator Superfamily protein XM40_09445 ENOG4105WAB arsR family transcriptional regulator XM40_09455 ENOG4108KSA LysR family transcriptional regulator XM40_09460 ENOG4105CB2 alcohol dehydrogenase XM40_09465 ENOG4105BZ8 glutamate synthase XM40_09470 ENOG4105CBC glutamate synthase XM40_09475 ENOG4105C5Q Transcriptional regulator XM40_09480 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) XM40_09505 ENOG4108UB7 XM40_09510 ENOG4105IE8 Alpha-ketoglutarate permease XM40_09515 ENOG4107U6E carbohydrate kinase FGGY XM40_09520 ENOG4108M3J Dehydrogenase XM40_09525 ENOG4108J2R molybdopterin oxidoreductase XM40_09545 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr XM40_09555 ENOG4108Z7R Chaperone CsaA XM40_09560 ENOG4105FTV AraC Family Transcriptional Regulator XM40_09570 ENOG4108W8B Beta-lactamase domain protein XM40_09580 ENOG4105KTU Transcriptional regulator, arsr family XM40_09590 ENOG4108SJC Membrane XM40_09615 ENOG41069ER domain protein XM40_09620 ENOG4105C9U ATP-dependent DNA helicase RecQ XM40_09625 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) XM40_09630 ENOG4105SCY DNAK suppressor XM40_09670 ENOG4105C26 Dehydrogenase XM40_09675 ENOG4105EWU Squalene--hopene cyclase XM40_09680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) XM40_09685 ENOG4105C8J )-transporter XM40_09690 ENOG4105C09 Bile acid XM40_09700 ENOG4105C7S Dehydrogenase XM40_09705 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 XM40_09710 ENOG4107T89 von Willebrand factor, type A XM40_09715 ENOG4105GMT ATPase associated with various cellular activities aaa_5 XM40_09725 ENOG4105K4H Nlp p60 protein XM40_09730 ENOG41087PP glycosyltransferase MGT family XM40_09740 ENOG4107QMU Mate efflux family protein XM40_09745 ENOG4106SCS STAS domain XM40_09765 ENOG4105FR1 rard protein XM40_09780 ENOG41090U3 tautomerase XM40_09800 ENOG4105FBA Phospholipase Carboxylesterase XM40_09815 ENOG4105E1V na solute symporter XM40_09825 ENOG4105CS2 ec 3.2.1.21 XM40_09830 ENOG4108S3Y transcriptional regulator XM40_09850 ENOG4108VXD carboxy-peptidase XM40_09855 ENOG4105D3A purine nucleoside phosphorylase DeoD-type XM40_09860 ENOG4106Z5R XM40_09865 ENOG410841Q phosphoesterase PA-phosphatase related protein XM40_09895 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein XM40_09900 ENOG4108TSC N-acetyltransferase XM40_09905 ENOG4107S4Y M20 DapE family protein YgeY XM40_09920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) XM40_09925 ENOG4105FTQ Dna gyrase XM40_09975 ENOG4105E0X reductase XM40_09980 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) XM40_09990 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) XM40_09995 ENOG41090WU lipolytic protein G-D-S-L family XM40_10000 ENOG4108KF3 Electron transport protein SCO1 SenC XM40_10010 ENOG4105C7B Threonine dehydratase XM40_10020 ENOG4108UT2 hemolysin iii XM40_10030 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) XM40_10035 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) XM40_10045 ENOG4107YX5 Pfam:DUF548 XM40_10050 ENOG4108Y6J UPF0403 protein XM40_10055 ENOG4105C01 Dihydroxy-acid dehydratase XM40_10070 ENOG4108V06 Glutathione peroxidase XM40_10075 ENOG4105CVG Homoserine O-transsuccinylase XM40_10115 ENOG41081VK Ribonuclease XM40_10135 ENOG410890F Dynamin family XM40_10145 ENOG41065KQ synthase XM40_10180 ENOG4105C2W permease XM40_10185 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) XM40_10190 ENOG4105CTD carboxy-peptidase XM40_10195 ENOG4105DVT helicase XM40_10210 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) XM40_10215 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) XM40_10220 ENOG4108UKS UPF0398 protein XM40_10225 ENOG4107X2U Inherit from COG: Exonuclease-like protein XM40_10230 ENOG4108I5C dEAD DEAH box helicase XM40_10275 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) XM40_10280 ENOG4105BZ4 penicillin-binding protein XM40_10290 ENOG4105CSM endonuclease III XM40_10300 ENOG4105C5S asparaginyl-tRNA synthetase XM40_10305 ENOG4105CHM Aminotransferase XM40_10315 ENOG4105DVT helicase XM40_10320 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) XM40_10330 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) XM40_10340 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate XM40_10345 ENOG4105CPK Glycosyl transferase (Group 1 XM40_10350 ENOG4105FJR Lmbe family XM40_10355 ENOG4108Z5K methylglyoxal synthase XM40_10360 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) XM40_10365 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase XM40_10370 ENOG4108JYZ YitT family XM40_10375 ENOG4105F0F Oxalate decarboxylase XM40_10395 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) XM40_10415 ENOG41068YB TPR repeat-containing protein XM40_10420 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase XM40_10430 ENOG4105CIH Imidazole acetol-phosphate transaminase XM40_10440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) XM40_10445 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase XM40_10450 ENOG4105DK0 Indole-3-glycerol phosphate synthase XM40_10460 ENOG4105CRQ synthase (Component I) XM40_10465 ENOG4105KHN chorismate mutase XM40_10475 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase XM40_10480 ENOG4105BZU Histidine kinase XM40_10485 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) XM40_10490 ENOG4105EAH synthase XM40_10495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) XM40_10500 ENOG4105XXQ heptaprenyl diphosphate synthase component I XM40_10505 ENOG4105WP2 Tryptophan RNA-binding attenuator protein XM40_10510 ENOG4105EUJ GTP cyclohydrolase i XM40_10515 ENOG4105K70 DNA-binding protein XM40_10520 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) XM40_10535 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase XM40_10540 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) XM40_10555 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) XM40_10560 ENOG4105CAT Cytidine monophosphate kinase XM40_10570 ENOG4105MSI germination protein ypeb XM40_10580 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) XM40_10585 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase XM40_10600 ENOG4107RGJ metallophosphoesterase XM40_10615 ENOG4105I7S Abortive infection protein XM40_10620 ENOG4105C9U ATP-dependent DNA helicase RecQ XM40_10625 ENOG4105T7X XM40_10635 ENOG4108SAX Membrane XM40_10640 ENOG4108JQ1 Dehydrogenase XM40_10655 ENOG4105BZU Histidine kinase XM40_10660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XM40_10665 ENOG4105CRE cytochrome C XM40_10670 ENOG4107TWT Cytochrome c biogenesis protein XM40_10680 ENOG4105FE9 pseudouridine synthase XM40_10690 ENOG4108JIC nucleoside recognition domain protein XM40_10695 ENOG4105DZ1 carboxypeptidase XM40_10705 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) XM40_10710 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) XM40_10725 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) XM40_10730 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) XM40_10735 ENOG4108R6K riboflavin synthase, subunit alpha XM40_10760 ENOG4107ZE5 PPIases accelerate the folding of proteins XM40_10765 ENOG4105PTM secreted protein XM40_10770 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) XM40_10780 ENOG4105G6R Stage v sporulation protein ae XM40_10790 ENOG4105CZ3 stage V sporulation protein ad XM40_10795 ENOG41090VF Stage v sporulation protein ac XM40_10810 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_10815 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) XM40_10820 ENOG41082AN stage II sporulation protein XM40_10825 ENOG4105DZ1 carboxypeptidase XM40_10830 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) XM40_10835 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) XM40_10840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) XM40_10850 ENOG4105I3K Ferric uptake regulator, Fur family XM40_10855 ENOG4105MZ9 stage II sporulation protein m XM40_10875 ENOG4105DFD Na H antiporter XM40_10880 ENOG4108IJ0 Aspartate ammonia-lyase XM40_10885 ENOG4105HDK L-asparaginase XM40_10890 ENOG4108IMY Transcriptional regulator XM40_10900 ENOG4108YZ4 nudix hydrolase XM40_10910 ENOG4105CPC Aldo Keto reductase XM40_10930 ENOG4106HZJ XM40_10935 ENOG4105RHY Pfam:UPF0157 XM40_10940 ENOG4105KAC Antibiotic biosynthesis monooxygenase XM40_10945 ENOG4108XET gCN5-related N-acetyltransferase XM40_10950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) XM40_10965 ENOG4105C02 permease XM40_10970 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase XM40_10975 ENOG4105CS9 pantothenic acid kinase XM40_10985 ENOG4108IXY short-chain dehydrogenase reductase XM40_10990 ENOG41069FQ Metallo-beta-lactamase superfamily XM40_10995 ENOG4105II7 pyrroline-5-carboxylate reductase XM40_11000 ENOG4108KQ6 Enoyl-CoA hydratase XM40_11005 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase XM40_11010 ENOG4106A3M Cytochrome p-450 XM40_11025 ENOG4105C0W non-ribosomal peptide synthetase XM40_11030 ENOG4105C0W non-ribosomal peptide synthetase XM40_11040 ENOG4105C0W non-ribosomal peptide synthetase XM40_11050 ENOG4105CHR reductase XM40_11055 ENOG4105CEY Amp-dependent synthetase and ligase XM40_11070 ENOG4107QKG PfaD family XM40_11075 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) XM40_11080 ENOG4108K70 Transcriptional regulator XM40_11090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase XM40_11100 ENOG410861F 50S ribosomal protein L33 XM40_11105 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) XM40_11110 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase XM40_11115 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) XM40_11120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) XM40_11130 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) XM40_11135 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) XM40_11140 ENOG4108HNZ carboxyl transferase XM40_11145 ENOG4108ZVT methylmalonyl-coA epimerase XM40_11150 ENOG4108VZI ErfK ybiS ycfS ynhG family protein XM40_11155 ENOG4108QEG Membrane XM40_11160 ENOG4105CDA abc transporter atp-binding protein XM40_11165 ENOG4105E5Q amino acid AbC transporter XM40_11170 ENOG4108HW3 (ABC) transporter XM40_11175 ENOG4108Y6J UPF0403 protein XM40_11180 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) XM40_11185 ENOG4105C7S Dehydrogenase XM40_11190 ENOG4105CPP Dehydrogenase, E1 component XM40_11205 ENOG4105CKM Branched-chain carboxylic acid kinase XM40_11210 ENOG4107RDP Dehydrogenase XM40_11220 ENOG4108JUB Transcriptional regulator XM40_11225 ENOG4106CCJ Protein of unknown function (DUF2627) XM40_11230 ENOG4105CR4 methylisocitrate lyase XM40_11235 ENOG4105DXD 2-methylcitrate dehydratase XM40_11245 ENOG4105C1G acyl-Coa dehydrogenase XM40_11250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase XM40_11260 ENOG4108QXE glycerophosphoryl diester phosphodiesterase XM40_11265 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase XM40_11290 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase XM40_11305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) XM40_11310 ENOG4107QQR Sporulation XM40_11315 ENOG4105S1Z Stage IV sporulation protein B XM40_11320 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) XM40_11325 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) XM40_11330 ENOG4105DX0 Hemolysin A XM40_11335 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) XM40_11340 ENOG4105CTB Polyprenyl synthetase XM40_11345 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) XM40_11350 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) XM40_11355 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) XM40_11360 ENOG4105M7K Involved in the transcription termination process (By similarity) XM40_11365 ENOG4108ZSR alkaline shock protein XM40_11370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase XM40_11390 ENOG410644B Stage III sporulation protein af XM40_11400 ENOG4105KQ4 Stage iii sporulation protein ad XM40_11405 ENOG4108CQH stage III sporulation protein AC XM40_11410 ENOG4105KR5 Stage iii sporulation protein XM40_11415 ENOG4105CD2 stage iii sporulation protein aa XM40_11425 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) XM40_11430 ENOG4105DC7 peptidase M24 XM40_11440 ENOG4105CBJ Metal-dependent enzyme XM40_11460 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) XM40_11465 ENOG4105WZW rhodanese family XM40_11470 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor XM40_11480 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) XM40_11485 ENOG4105C0D helicase XM40_11500 ENOG4108IMY Transcriptional regulator XM40_11510 ENOG4105VFR signal peptidase XM40_11570 ENOG4105C37 (CBS) domain XM40_11595 ENOG4105C5X domain protein XM40_11635 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase XM40_11645 ENOG41068DG YceG-like family XM40_11650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) XM40_11655 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) XM40_11660 ENOG4105E2Z phosphate ABC transporter (Permease XM40_11665 ENOG4105C8U phosphate abc transporter XM40_11670 ENOG4105CVA phosphate XM40_11675 ENOG4107RF6 penicillin-binding protein XM40_11685 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) XM40_11690 ENOG4105SXS Protein of unknown function (DUF456) XM40_11705 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) XM40_11710 ENOG41063Y9 XM40_11715 ENOG4108U5J '-nucleotidase XM40_11720 ENOG4105N80 Ferric uptake regulator, Fur family XM40_11725 ENOG4108JYZ YitT family XM40_11730 ENOG41069ZM Protein of unknown function (DUF2624) XM40_11735 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) XM40_11750 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) XM40_11755 ENOG4105EGD dinuclear metal center protein, YbgI family XM40_11770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_11775 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) XM40_11780 ENOG4108UPT UPF0178 protein XM40_11785 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) XM40_11795 ENOG4105C38 Glycyl-tRNA synthetase beta subunit XM40_11800 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit XM40_11805 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) XM40_11810 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) XM40_11815 ENOG4105KG3 cytidine deaminase XM40_11820 ENOG4107YR5 Diacylglycerol kinase XM40_11825 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) XM40_11830 ENOG4105CTJ Metal Dependent Phosphohydrolase XM40_11835 ENOG4105C9A Phoh family XM40_11840 ENOG4105EI1 sporulation protein yqfd XM40_11845 ENOG41068P3 sporulation protein YqfC XM40_11855 ENOG4105DI5 UPF0365 protein XM40_11860 ENOG4105F7J membrane-bound serine protease XM40_11865 ENOG4105KTH gatB Yqey XM40_11880 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) XM40_11885 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) XM40_11890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) XM40_11895 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) XM40_11900 ENOG4105CFG Acts as a chaperone (By similarity) XM40_11905 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ XM40_11910 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) XM40_11915 ENOG4105CSA Coproporphyrinogen iii oxidase XM40_11920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) XM40_11930 ENOG4108ZRV stage ii sporulation protein p XM40_11935 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) XM40_11940 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) XM40_11945 ENOG4105TQK DNA polymerase iii, delta' subunit XM40_11955 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 XM40_11960 ENOG4108UK2 deaminase XM40_11965 ENOG4105KQC Competence protein XM40_11975 ENOG4108D32 Methyltransferase XM40_11985 ENOG4108WF2 Metal Dependent Phosphohydrolase XM40_11990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) XM40_11995 ENOG410812S Rna-binding protein XM40_12000 ENOG4105E2X shikimate dehydrogenase XM40_12005 ENOG4105CQW ribosome biogenesis GTPase YqeH XM40_12010 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase XM40_12030 ENOG41080BT SNARE associated Golgi XM40_12040 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_12055 ENOG41086D8 Transcriptional regulator XM40_12060 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) XM40_12070 ENOG4108J8C transporter major facilitator family protein XM40_12075 ENOG4108U7W acetyltransferase XM40_12090 ENOG4105DQF Hydrolase XM40_12095 ENOG4108HCJ Hydrolase XM40_12105 ENOG4105DG6 mannose-6-phosphate isomerase XM40_12110 ENOG4105DM4 PTS System XM40_12125 ENOG4108Z66 YbaK ebsC protein XM40_12130 ENOG4107RSM transcriptional regulator XM40_12135 ENOG4105D94 Major Facilitator Superfamily XM40_12140 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) XM40_12145 ENOG41082JN Transcriptional regulator XM40_12160 ENOG4105TMB Formate nitrite transporter XM40_12165 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) XM40_12170 ENOG4108JB9 formate dehydrogenase XM40_12185 ENOG4105C28 cystathionine XM40_12215 ENOG4107XRG penicillin-binding protein XM40_12220 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) XM40_12230 ENOG4105CFP Peptidase U32 XM40_12235 ENOG4105XYU peptidase (U32 family) XM40_12240 ENOG4108VQJ O-methyltransferase XM40_12245 ENOG4105HHA aminodeoxychorismate lyase XM40_12255 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) XM40_12260 ENOG4105VBH UPF0297 protein XM40_12265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) XM40_12270 ENOG4105C02 permease XM40_12275 ENOG4105CDA abc transporter atp-binding protein XM40_12280 ENOG4105CT1 (ABC) transporter XM40_12285 ENOG4105EAD ABC transporter XM40_12290 ENOG4105DRP amino acid AbC transporter XM40_12295 ENOG41060CR XM40_12305 ENOG4105C7H Helicase, RecD TraA family XM40_12315 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) XM40_12320 ENOG4105C3J Cysteine desulfurase XM40_12330 ENOG4105D1H recombination factor protein RarA XM40_12335 ENOG4105CUZ uba thif-type nad fad binding protein XM40_12340 ENOG4105C9M aspartyl-trna synthetase XM40_12345 ENOG4105CUT histidyl-tRNA synthetase XM40_12350 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase XM40_12355 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) XM40_12360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) XM40_12370 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) XM40_12375 ENOG41067VP Protein of unknown function (DUF1049) XM40_12380 ENOG4105NCW Trka-c domain protein XM40_12385 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) XM40_12395 ENOG4105CKP Polysaccharide Biosynthesis Protein XM40_12400 ENOG4108QG2 Membrane XM40_12405 ENOG4105NAP XM40_12410 ENOG4105VIE preprotein translocase, subunit YajC XM40_12415 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) XM40_12420 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) XM40_12425 ENOG41061AI Protein of unknown function (DUF2905) XM40_12430 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) XM40_12435 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) XM40_12455 ENOG4106678 morphogenetic protein associated with SpoVID XM40_12460 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) XM40_12465 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase XM40_12470 ENOG4108IYU L-aspartate oxidase XM40_12485 ENOG4105CQC Prephenate dehydratase XM40_12495 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control XM40_12505 ENOG4105K46 50S ribosomal protein l27 XM40_12510 ENOG4105X36 (ribosomal) protein XM40_12515 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) XM40_12530 ENOG4107QMS site-determining protein XM40_12535 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) XM40_12540 ENOG4105YHC Rod shape-determining protein MreD XM40_12545 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) XM40_12550 ENOG4105DFF Rod shape-determining protein mreb XM40_12555 ENOG4105W5Q DNA repair protein (RadC XM40_12560 ENOG4108Z03 MAF-like protein XM40_12570 ENOG4106A3R peptidase XM40_12575 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase XM40_12580 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) XM40_12590 ENOG4106AR7 Spore coat protein XM40_12595 ENOG41068KH stage VI sporulation protein D XM40_12600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase XM40_12605 ENOG4105D52 delta-aminolevulinic acid dehydratase XM40_12615 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) XM40_12625 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) XM40_12635 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) XM40_12640 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) XM40_12645 ENOG4108IUQ atp-dependent protease XM40_12650 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) XM40_12655 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation XM40_12665 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) XM40_12670 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) XM40_12675 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) XM40_12685 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase XM40_12690 ENOG4108ZP8 Acetolactate synthase small subunit XM40_12695 ENOG4105C7K acetolactate synthase XM40_12725 ENOG4107SCJ type I restriction enzyme EcoKI subunit R XM40_12745 ENOG4105M59 Phosphodiesterase, mj0936 family XM40_12750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) XM40_12755 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) XM40_12760 ENOG4108XJQ germination protein XM40_12765 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) XM40_12770 ENOG41067TZ transcriptional regulator, MarR family XM40_12775 ENOG4105PFC Transcriptional regulator XM40_12785 ENOG4105E33 succinate dehydrogenase XM40_12795 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit XM40_12805 ENOG4105CFH Aspartokinase XM40_12810 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) XM40_12815 ENOG4105K63 Thioredoxin XM40_12820 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) XM40_12825 ENOG4105C10 Electron transfer flavoprotein XM40_12830 ENOG4105BZJ Electron transfer flavoprotein XM40_12835 ENOG41060WC Enoyl-CoA hydratase XM40_12840 ENOG4107Z3H Transcriptional regulator, TetR family XM40_12845 ENOG4105CEY Amp-dependent synthetase and ligase XM40_12860 ENOG4105C98 muts2 protein XM40_12865 ENOG4105DCG PHP domain protein XM40_12880 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) XM40_12885 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) XM40_12890 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) XM40_12895 ENOG4108RWN rrna methyltransferase XM40_12900 ENOG41067MF small acid-soluble spore protein XM40_12910 ENOG4105CQB FAD linked oxidase domain protein XM40_12915 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) XM40_12925 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) XM40_12930 ENOG4105DRS transport system, permease XM40_12945 ENOG4108MDK Dehydrogenase XM40_12955 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase XM40_12960 ENOG4105EF1 ribulokinase XM40_12970 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase XM40_12975 ENOG4105CN9 Peptidase m42 family protein XM40_12985 ENOG410696E Membrane XM40_12990 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) XM40_12995 ENOG4105VJV 50s ribosomal protein L35 XM40_13000 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) XM40_13005 ENOG41067MG lrgb family XM40_13015 ENOG4105DY9 regulatoR XM40_13020 ENOG4108HRK Histidine kinase XM40_13025 ENOG4105U0R haloacid dehalogenase-like hydrolase XM40_13030 ENOG4105C22 threonyL-tRNA synthetase XM40_13035 ENOG4108TDW sporulation protein YtxC XM40_13060 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) XM40_13065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase XM40_13070 ENOG4105KVH Transcriptional regulator XM40_13075 ENOG4105F27 Major Facilitator XM40_13080 ENOG4105CV8 reductase XM40_13085 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) XM40_13095 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) XM40_13100 ENOG4105C2M dna polymerase I XM40_13105 ENOG4105BZU Histidine kinase XM40_13110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XM40_13120 ENOG4108HMX isocitrate dehydrogenase (NADP) XM40_13125 ENOG4105BZN citrate synthase XM40_13130 ENOG4105G7B Protein of unknown function (DUF2992) XM40_13140 ENOG4108REF Sporulation integral membrane protein ytvi XM40_13145 ENOG4105FS0 cytoplasmic membrane protein XM40_13150 ENOG4105CA9 Pyruvate kinase XM40_13155 ENOG4105CTQ phosphohexokinase XM40_13160 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) XM40_13165 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) XM40_13175 ENOG4105C6K Malic enzyme XM40_13180 ENOG4105C0B DNA polymerase III (alpha subunit) XM40_13185 ENOG4105VV2 XM40_13195 ENOG4106EVM XM40_13200 ENOG4105SFS phosphoesterase RecJ domain protein XM40_13215 ENOG4105E8R UPF0173 metal-dependent hydrolase XM40_13225 ENOG4105CH7 arginosuccinase XM40_13230 ENOG4105CDH Citrulline--aspartate ligase XM40_13235 ENOG4105EPU Molybdenum cofactor synthesis domain protein XM40_13240 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) XM40_13250 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) XM40_13255 ENOG4105KBJ sporulation protein ytfj XM40_13265 ENOG4105VK3 rdd domain containing protein XM40_13270 ENOG4105D07 Signal peptide peptidase, SppA XM40_13275 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) XM40_13280 ENOG4105EFZ amidohydrolase XM40_13285 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) XM40_13295 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) XM40_13320 ENOG4105U5Y Transcriptional regulator XM40_13330 ENOG4105BZU Histidine kinase XM40_13335 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) XM40_13340 ENOG4105C26 Dehydrogenase XM40_13350 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) XM40_13360 ENOG4108Z0Z intracellular protease Pfpi family XM40_13380 ENOG4108NGU Transcriptional regulator XM40_13395 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) XM40_13405 ENOG4105F1V Acetoin utilization protein XM40_13410 ENOG4105W87 Cbs domain XM40_13415 ENOG4105DGU Histone deacetylase XM40_13420 ENOG4105ER2 Ompa motb domain protein XM40_13425 ENOG4107R0U MotA TolQ exbB proton channel XM40_13430 ENOG4105ETE Transcriptional regulator (LacI family XM40_13435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase XM40_13455 ENOG4105DFU Cell wall formation (By similarity) XM40_13465 ENOG4108VDD TRNA binding domain protein XM40_13480 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ XM40_13495 ENOG4105C6K Malic enzyme XM40_13500 ENOG4105C8F Beta-lactamase domain protein XM40_13505 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) XM40_13515 ENOG4108V15 phosphotransferase enzyme family XM40_13530 ENOG4107F58 2'-5' rna ligase XM40_13535 ENOG4105C6T cysteine synthase XM40_13540 ENOG4107QSE Dipeptidase XM40_13545 ENOG4105C7N Xanthine uracil vitamin C permease XM40_13560 ENOG4105YW5 deoR family transcriptional regulator XM40_13575 ENOG4105CBX hi0933 family XM40_13580 ENOG4105C94 Transporter XM40_13600 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component XM40_13605 ENOG4105I1K ABC transporter XM40_13620 ENOG41085GJ domain protein XM40_13625 ENOG4105C8T Leucyl-tRNA synthetase XM40_13635 ENOG4105BZU Histidine kinase XM40_13640 ENOG410605W Major Facilitator XM40_13655 ENOG4105C19 ABC transporter XM40_13660 ENOG4105EWM Histidine kinase XM40_13670 ENOG4107R34 abc transporter permease protein XM40_13675 ENOG4105C19 ABC transporter XM40_13695 ENOG4105DVE abc transporter atp-binding protein XM40_13700 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family XM40_13710 ENOG4105N5T Radical SAM Protein XM40_13725 ENOG4107VXM glycerophosphoryl diester phosphodiesterase XM40_13735 ENOG4105E8V Alpha Beta Hydrolase Fold protein XM40_13740 ENOG4108Z0R Transferase XM40_13745 ENOG4105C85 amino acid XM40_13750 ENOG4105CAQ asparagine synthetase XM40_13755 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP XM40_13760 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase XM40_13775 ENOG4105D2X ABC transporter substrate-binding protein XM40_13785 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component XM40_13800 ENOG4108RMU ferritin dps family protein XM40_13815 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) XM40_13820 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) XM40_13825 ENOG4108V2W Carbonate dehydratase XM40_13830 ENOG4105NRA 50s ribosomal protein l31 type b XM40_13845 ENOG4105DTQ mandelate racemase muconate lactonizing XM40_13850 ENOG4105CEY Amp-dependent synthetase and ligase XM40_13855 ENOG4108IPT Naphthoate synthase XM40_13860 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) XM40_13865 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) XM40_13870 ENOG4105E4F Isochorismate synthase XM40_14010 ENOG4105N67 Proton-coupled thiamine transporter YuaJ XM40_14015 ENOG4105DZ6 Band 7 protein XM40_14025 ENOG4106DF1 XM40_14030 ENOG4108VNY MOSC domain protein XM40_14035 ENOG4108JB8 alcohol dehydrogenase XM40_14040 ENOG4105C26 Dehydrogenase XM40_14045 ENOG4105TRT Transcriptional regulator XM40_14060 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj XM40_14065 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) XM40_14085 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) XM40_14095 ENOG4105EE0 oxidoreductase XM40_14100 ENOG4108Z0Z intracellular protease Pfpi family XM40_14105 ENOG4105C8Q Methyl-accepting chemotaxis XM40_14110 ENOG4105C8Q Methyl-accepting chemotaxis XM40_14115 ENOG4105C8Q Methyl-accepting chemotaxis XM40_14120 ENOG4105C8Q Methyl-accepting chemotaxis XM40_14135 ENOG4105EA8 2-Nitropropane dioxygenase XM40_14140 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme XM40_14150 ENOG4105C37 (CBS) domain XM40_14165 ENOG4107PBV potassium channel XM40_14170 ENOG4107PBV potassium channel XM40_14185 ENOG4107QYV phosphohexose isomerase XM40_14195 ENOG4105CHJ isochorismatase hydrolase XM40_14205 ENOG4107QW4 alcohol dehydrogenase XM40_14210 ENOG4105WG9 Conserved Protein XM40_14220 ENOG4105CHM Aminotransferase XM40_14225 ENOG4108ZB6 transcriptional regulator AsnC family XM40_14230 ENOG4108MUZ hydrolase XM40_14240 ENOG4105C87 Aminotransferase class I and II XM40_14245 ENOG4108HGU Histidine kinase XM40_14250 ENOG4105Y38 Kinase-associated protein B XM40_14265 ENOG4105BZ4 penicillin-binding protein XM40_14270 ENOG4105KIR Thiol-disulfide oxidoreductase dcc XM40_14285 ENOG4108MRH transcriptional regulatory protein XM40_14290 ENOG4105DIH basic membrane XM40_14295 ENOG4108JQ9 ABC transporter XM40_14300 ENOG4105UIB (ABC) transporter XM40_14315 ENOG4105D65 subunit l XM40_14320 ENOG4105HC0 Na H antiporter XM40_14325 ENOG4108ZE9 Monovalent cation H antiporter subunit C XM40_14330 ENOG4108JPZ Monovalent cation H antiporter subunit D XM40_14335 ENOG4105SC1 monovalent cation H antiporter subunit E XM40_14345 ENOG4105KJM monovalent cation h antiporter subunit g XM40_14350 ENOG4105KA0 thioesterase Superfamily protein XM40_14360 ENOG4105BZU Histidine kinase XM40_14385 ENOG4105D58 Diguanylate phosphodiesterase XM40_14390 ENOG4105DAP Nicotinate phosphoribosyltransferase XM40_14415 ENOG4105C02 permease XM40_14430 ENOG410904N short-chain dehydrogenase reductase XM40_14465 ENOG4108K8K Transcriptional regulator XM40_14470 ENOG4105DCF alanine dehydrogenase XM40_14480 ENOG4105WQT MbtH domain protein XM40_14485 ENOG4105CEY Amp-dependent synthetase and ligase XM40_14490 ENOG4105WQI isochorismatase XM40_14495 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase XM40_14500 ENOG4105E4F Isochorismate synthase XM40_14505 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase XM40_14510 ENOG4105NIV Esterase XM40_14530 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) XM40_14540 ENOG41069ER domain protein XM40_14550 ENOG4105CEP NADH dehydrogenase XM40_14565 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) XM40_14580 ENOG4105CJ1 ABC, transporter XM40_14605 ENOG4108VHC Short-chain dehydrogenase reductase Sdr XM40_14610 ENOG4108YX9 iron--sulfur cluster insertion protein erpA XM40_14615 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) XM40_14625 ENOG4105ZKE UPF0349 protein XM40_14640 ENOG41083MR nifu domain-containing protein XM40_14645 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein XM40_14650 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) XM40_14655 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) XM40_14660 ENOG4105D6E homoserine dehydrogenase XM40_14670 ENOG4108W5N phosphatidylglycerophosphatase a XM40_14675 ENOG4105D4U had-superfamily hydrolase, subfamily iia XM40_14685 ENOG4105MMD transcriptional regulator XM40_14690 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) XM40_14695 ENOG4105FAA peptidase M23 XM40_14700 ENOG4108YTE sporulation protein YunB XM40_14705 ENOG4107R8B 5'-nucleotidase XM40_14715 ENOG4105I3N Conserved Protein XM40_14725 ENOG4105CD3 dihydroorotase XM40_14730 ENOG4105G9B Transcriptional regulator XM40_14760 ENOG4105C5R Aminotransferase XM40_14770 ENOG4108K8S endonuclease I XM40_14775 ENOG4108IJ9 (ABC) transporter XM40_14780 ENOG4105FDP GntR family transcriptional regulator XM40_14785 ENOG4108KPW sugar kinase XM40_14790 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component XM40_14795 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component XM40_14800 ENOG4105XN3 extracellular solute-binding protein family 1 XM40_14805 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine XM40_14815 ENOG4105PKS Excinuclease abc c subunit domain protein XM40_14820 ENOG4107VFR oxidoreductase XM40_14830 ENOG41083Q9 chitosanase XM40_14835 ENOG4105DIW FeS assembly protein SUFB XM40_14840 ENOG4108UNV SUF system FeS assembly protein, NifU family XM40_14845 ENOG4105C9B Cysteine desulfurase XM40_14850 ENOG4105JRK feS assembly protein SufD XM40_14855 ENOG4105C3K feS assembly ATPase SufC XM40_14865 ENOG4105D01 (LipO)protein XM40_14870 ENOG4108UMI ABC transporter, permease XM40_14875 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) XM40_14900 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) XM40_14905 ENOG41080E8 Transcriptional regulator, Spx MgsR family XM40_14910 ENOG4105C1G acyl-Coa dehydrogenase XM40_14915 ENOG4105CHU acetyl-coa acetyltransferase XM40_14940 ENOG41067TZ transcriptional regulator, MarR family XM40_14945 ENOG4105C0R drug resistance transporter emrb qaca subfamily XM40_14950 ENOG4105C5Q Transcriptional regulator XM40_14970 ENOG4105E0A ABC, transporter XM40_14985 ENOG4105E1F short-chain dehydrogenase reductase XM40_14990 ENOG4105HUF DNA protection during starvation protein XM40_14995 ENOG4105C0H protease XM40_15005 ENOG4105F3H Histidine kinase XM40_15010 ENOG41067SE Tetr family transcriptional regulator XM40_15015 ENOG4105C9Q fumarate hydratase class II XM40_15040 ENOG4105WH1 Two component transcriptional regulator luxr family XM40_15045 ENOG4105ENE Histidine kinase XM40_15060 ENOG41087YS Phage shock protein A XM40_15075 ENOG4108WBT adenosyltransferase XM40_15080 ENOG4105E0A ABC, transporter XM40_15085 ENOG4105EHG Permease protein XM40_15090 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) XM40_15095 ENOG4105EWI Short-chain dehydrogenase reductase Sdr XM40_15100 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein XM40_15110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XM40_15120 ENOG4106DF4 Sigma-70, region 4 XM40_15125 ENOG4105F0F Oxalate decarboxylase XM40_15135 ENOG4105E0A ABC, transporter XM40_15140 ENOG4105EHG Permease protein XM40_15145 ENOG4105DQ5 transport system permease protein XM40_15155 ENOG4105JQZ Methyltransferase XM40_15160 ENOG4105D5Q Arginine ornithine antiporter XM40_15170 ENOG4107K5X Membrane-bound metal-dependent hydrolase XM40_15175 ENOG4107QZ2 Sulfatase XM40_15180 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family XM40_15185 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein XM40_15190 ENOG4105E0C molybdate abc transporter XM40_15195 ENOG4105WH1 Two component transcriptional regulator luxr family XM40_15200 ENOG4105BZU Histidine kinase XM40_15205 ENOG4105CJ1 ABC, transporter XM40_15215 ENOG4108KYE ABC-2 type transporter XM40_15230 ENOG4105EEQ Na H antiporter XM40_15240 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) XM40_15245 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) XM40_15250 ENOG4105EEM helicase XM40_15255 ENOG4105EN6 Membrane XM40_15270 ENOG4107ZQN disulfide bond XM40_15275 ENOG4105C59 p-type ATPase XM40_15280 ENOG4105C59 p-type ATPase XM40_15285 ENOG410681U heavy metal transport detoxification protein XM40_15290 ENOG4105VPX protein, conserved in bacteria XM40_15295 ENOG4105D9R oxidoreductase XM40_15300 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) XM40_15335 ENOG4105DEN Luciferase family XM40_15340 ENOG4105CDA abc transporter atp-binding protein XM40_15365 ENOG4108XSB acetyltransferase, (GNAT) family XM40_15370 ENOG4108KSA LysR family transcriptional regulator XM40_15375 ENOG4105EWI Short-chain dehydrogenase reductase Sdr XM40_15380 ENOG41067XF inhibitor XM40_15385 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) XM40_15390 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) XM40_15400 ENOG4105XZU Preprotein translocase, subunit SecG XM40_15420 ENOG4105KVH Transcriptional regulator XM40_15445 ENOG4105DA5 (ABC) transporter XM40_15450 ENOG4105R40 Glycine betaine carnitine choline XM40_15455 ENOG4108HQR Glycine betaine XM40_15460 ENOG4105E90 ABC transporter XM40_15465 ENOG4108IJ8 ABC transporter XM40_15470 ENOG4107HG4 Transcriptional regulator XM40_15475 ENOG4105R40 Glycine betaine carnitine choline XM40_15480 ENOG4108HQR Glycine betaine XM40_15485 ENOG4105E90 ABC transporter XM40_15490 ENOG4108IJ8 ABC transporter XM40_15495 ENOG4107HG4 Transcriptional regulator XM40_15500 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein XM40_15510 ENOG4105T65 Membrane-associated protein XM40_15515 ENOG4108W0I acetyltransferase XM40_15530 ENOG4105FJR Lmbe family XM40_15545 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase XM40_15550 ENOG4108IAJ Nad-dependent epimerase dehydratase XM40_15555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase XM40_15560 ENOG4107QQG Dehydrogenase XM40_15565 ENOG4105IIU Aminopeptidase XM40_15570 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) XM40_15575 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) XM40_15580 ENOG4105CP7 Triose-phosphate isomerase XM40_15585 ENOG4105BZA Phosphoglycerate kinase XM40_15595 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase XM40_15610 ENOG4105CMD Transcriptional regulator, GntR family XM40_15615 ENOG4105DEN Luciferase family XM40_15625 ENOG4105GZI Transcriptional regulator XM40_15630 ENOG4107RT3 EamA-like transporter family XM40_15640 ENOG4106KNT transcriptional regulator XM40_15645 ENOG4105CMG Carbohydrate kinase XM40_15650 ENOG4105C6Z Gluconate XM40_15660 ENOG4107QR9 Iron-sulfur cluster binding protein XM40_15665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) XM40_15670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XM40_15675 ENOG4105JXH GntR family transcriptional regulator XM40_15680 ENOG4105DAA L-lactate XM40_15685 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XM40_15695 ENOG4108ZPC Polysaccharide pyruvyl transferase XM40_15700 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase XM40_15705 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family XM40_15710 ENOG4105D3Q Sugar transferase XM40_15720 ENOG4105K64 Glycosyl transferase, family 2 XM40_15730 ENOG4107QRS glycosyltransferase group 2 family protein XM40_15735 ENOG41068W6 Capsular polysaccharide biosynthesis protein XM40_15740 ENOG4108KMV Glycosyl transferase (Group 1 XM40_15745 ENOG4105K64 Glycosyl transferase, family 2 XM40_15750 ENOG4108PQP glycosyl transferase group 1 XM40_15760 ENOG4108QV3 biosynthesis protein XM40_15765 ENOG4105HTX biosynthesis protein XM40_15775 ENOG4105EBR Carboxylesterase XM40_15780 ENOG4105NAE bifunctional deaminase-reductase domain protein XM40_15790 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 XM40_15795 ENOG4105PY6 Phenolic acid decarboxylase XM40_15840 ENOG4108HKT sucrose-6-phosphate hydrolase XM40_15845 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) XM40_15850 ENOG4105ETE Transcriptional regulator (LacI family XM40_15855 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XM40_15860 ENOG4108KAM Transcriptional regulator XM40_15865 ENOG4105C7F AcnD-accessory protein PrpF XM40_15875 ENOG4108URH decarboxylase XM40_15880 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain XM40_15885 ENOG4105CHH sulfate transporter XM40_15890 ENOG4108V2W Carbonate dehydratase XM40_15900 ENOG4105C5I Dehydrogenase XM40_15905 ENOG4105GGE ribonuclease XM40_15910 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase XM40_15915 ENOG4105KRI phosphocarrier protein (HPr XM40_15920 ENOG4105CIE May be required for sporulation (By similarity) XM40_15925 ENOG4105CHW UPF0052 protein XM40_15930 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) XM40_15935 ENOG4108Z4K mutator MutT protein XM40_15940 ENOG4105C3M thioredoxin reductase XM40_15955 ENOG4105BZU Histidine kinase XM40_15960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XM40_15970 ENOG4105BZ1 (ABC) transporter XM40_15975 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase XM40_15980 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) XM40_15985 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase XM40_15990 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) XM40_15995 ENOG4105ECC imidazole-glycerol-phosphate dehydratase XM40_16000 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) XM40_16005 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) XM40_16010 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) XM40_16020 ENOG4108S4C acetyltransferase XM40_16025 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) XM40_16035 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) XM40_16040 ENOG4105CE4 GlcNAc 6-P deacetylase XM40_16045 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) XM40_16050 ENOG4105FDP GntR family transcriptional regulator XM40_16055 ENOG4105J7D transcriptional regulator XM40_16060 ENOG41088CQ domain protein XM40_16065 ENOG41086DT Membrane protein of unknown function XM40_16070 ENOG41067S9 phage shock protein C, PspC XM40_16075 ENOG4108PY7 XM40_16090 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) XM40_16095 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) XM40_16110 ENOG4105MKU Transcriptional regulator XM40_16150 ENOG4105CN1 protease XM40_16155 ENOG4108M26 parallel beta-helix repeat protein XM40_16160 ENOG4105CRP Part of the ABC transporter FtsEX involved in XM40_16165 ENOG4105CAK Cell division ATP-binding protein ftsE XM40_16180 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) XM40_16185 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving XM40_16190 ENOG4105MS2 ribosomal subunit Interface protein XM40_16205 ENOG4105MQ3 flagellar protein FliS XM40_16210 ENOG4107RT6 flagellar hook-associated XM40_16215 ENOG4105I03 Flagellin XM40_16220 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) XM40_16225 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) XM40_16235 ENOG4105DTJ flagellar hook-associated protein XM40_16240 ENOG4105E1Q flagellar hook-associated protein XM40_16255 ENOG4105RU3 XM40_16260 ENOG41081UC Inherit from COG: Competence protein XM40_16280 ENOG4105WH1 Two component transcriptional regulator luxr family XM40_16285 ENOG4105BZU Histidine kinase XM40_16290 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein XM40_16295 ENOG4108KGH TRANSCRIPTIONal XM40_16300 ENOG4105ESV Glycosyl transferase, family 4 XM40_16305 ENOG4107EF8 Glycosyl transferase (Group 1 XM40_16320 ENOG4105QZI O-Antigen Polymerase XM40_16325 ENOG4105C6Y Udp-glucose 6-dehydrogenase XM40_16330 ENOG4107RA4 Glycosyl transferase (Group 1 XM40_16335 ENOG4105PSV Polysaccharide Biosynthesis Protein XM40_16340 ENOG4105D3Q Sugar transferase XM40_16345 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase XM40_16350 ENOG4105JFG SpoIID LytB domain protein XM40_16365 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase XM40_16370 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase XM40_16375 ENOG4105EY8 ABC transporter XM40_16385 ENOG4107SJB teichoic acid biosynthesis XM40_16395 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase XM40_16405 ENOG4107RZX Teichoic acid biosynthesis protein XM40_16415 ENOG4105DG6 mannose-6-phosphate isomerase XM40_16430 ENOG4108NHD germination protein XM40_16435 ENOG4107R8N Glycosyl transferase, family 2 XM40_16440 ENOG4105C54 Major Facilitator superfamily XM40_16445 ENOG4108KGH TRANSCRIPTIONal XM40_16450 ENOG4105J7I hydrolase XM40_16455 ENOG4106UBQ XM40_16460 ENOG4105K4H Nlp p60 protein XM40_16465 ENOG4105PNM synthesis protein XM40_16475 ENOG4105N98 Capsule biosynthesis protein capB XM40_16480 ENOG4105E1K spore germination protein XM40_16495 ENOG4105ETE Transcriptional regulator (LacI family XM40_16500 ENOG4108RVA ribokinase XM40_16505 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) XM40_16510 ENOG4105C2J ABC transporter XM40_16515 ENOG4105CNN ABC, transporter XM40_16520 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator XM40_16530 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein XM40_16535 ENOG4107FQX Alpha-acetolactate decarboxylase XM40_16545 ENOG4107RSM transcriptional regulator XM40_16560 ENOG4106UIA XM40_16575 ENOG4107XC4 flavin reductase domain protein, FMN-binding XM40_16595 ENOG4105CAH Chromate XM40_16600 ENOG4105FGV Chromate XM40_16610 ENOG4108WS4 fmn reductase XM40_16615 ENOG4107V2S Transcriptional regulator XM40_16620 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) XM40_16650 ENOG4108XI2 Domain of unknown function (DUF1963) XM40_16655 ENOG4105C6Y Udp-glucose 6-dehydrogenase XM40_16660 ENOG4108RB3 Capsular polysaccharide biosynthesis protein XM40_16665 ENOG4107YJ4 chain length determinant protein XM40_16670 ENOG4105HTX biosynthesis protein XM40_16675 ENOG4105KBK Zinc finger, swim domain protein XM40_16680 ENOG4105C0D helicase XM40_16685 ENOG410667J hydrolase XM40_16690 ENOG4105E98 transcriptional regulator DeoR family XM40_16695 ENOG4105Z8H single-stranded DNA-binding protein XM40_16710 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) XM40_16715 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) XM40_16725 ENOG4105CGA flagellar basal-body rod protein FlgG XM40_16735 ENOG4105DFF Rod shape-determining protein mreb XM40_16740 ENOG4105MT0 Sporulation transcriptional regulator spoiiid XM40_16745 ENOG4107MII Sugar-specific transcriptional regulator TrmB XM40_16750 ENOG4105CZM Major Facilitator XM40_16755 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease XM40_16760 ENOG41080V3 Major Facilitator superfamily XM40_16765 ENOG4105D3W isochorismatase XM40_16770 ENOG4105BZU Histidine kinase XM40_16780 ENOG4105CNI cell division protein FtsW XM40_16785 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase XM40_16795 ENOG4105FRN stage II sporulation protein XM40_16800 ENOG4107TCE N-acetyltransferase XM40_16815 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) XM40_16820 ENOG4106BRK XM40_16825 ENOG4107T94 Endo-14-beta-xylanase XM40_16835 ENOG4108Z40 Transcriptional regulator XM40_16840 ENOG4105CQM Urea amidohydrolase subunit alpha XM40_16845 ENOG4105KI2 Urea amidohydrolase subunit beta XM40_16850 ENOG4108YZ9 Urea amidohydrolase subunit gamma XM40_16870 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) XM40_16875 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) XM40_16880 ENOG4108TF4 von Willebrand factor, type A XM40_16895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) XM40_16905 ENOG4106778 Protein of unknown function (DUF1146) XM40_16915 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) XM40_16920 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) XM40_16925 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) XM40_16930 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) XM40_16935 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) XM40_16950 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) XM40_16960 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) XM40_16965 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) XM40_16970 ENOG4108UIC UPF0340 protein XM40_16975 ENOG4108YZG isomerase XM40_16980 ENOG4107WAU Protein tyrosine phosphatase XM40_16985 ENOG410815N Probably functions as a manganese efflux pump (By similarity) XM40_16990 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) XM40_17000 ENOG4108ZXQ stage ii sporulation protein r XM40_17015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) XM40_17020 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) XM40_17025 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase XM40_17035 ENOG4107TT2 Auxin Efflux Carrier XM40_17040 ENOG4105C6K Malic enzyme XM40_17045 ENOG4107104 thymidine kinase XM40_17050 ENOG41082DI 50s ribosomal protein l31 XM40_17055 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) XM40_17060 ENOG4105CBT Fructose-1,6-bisphosphatase XM40_17065 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) XM40_17075 ENOG4105D2N Aldolase XM40_17080 ENOG410812K response regulator receiver protein XM40_17090 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) XM40_17100 ENOG4105DF6 Fe-S oxidoreductase XM40_17110 ENOG4105E5J UV damage endonuclease XM40_17120 ENOG4105BZ1 (ABC) transporter XM40_17125 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) XM40_17140 ENOG4105R3A Nitrate reductase XM40_17145 ENOG4108IUE nitrate reductase beta subunit XM40_17165 ENOG4107V6Q Cyclic nucleotide-binding domain XM40_17175 ENOG4105C75 arginyL-tRNA synthetase XM40_17180 ENOG410684U Domain of unknown function (DUF1934) XM40_17185 ENOG4107JM4 Tetratricopeptide repeat XM40_17220 ENOG4105CYW agmatinase XM40_17225 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) XM40_17230 ENOG4105BZ4 penicillin-binding protein XM40_17240 ENOG4108XFG YwhD family XM40_17245 ENOG4108Z4T Peptidase M50 XM40_17250 ENOG41069HH 4-oxalocrotonate tautomerase XM40_17255 ENOG41067TZ transcriptional regulator, MarR family XM40_17265 ENOG4105CUB amino acid XM40_17275 ENOG4105DCI Phosphohydrolase XM40_17285 ENOG4108VCI transcription factor, rsfa family XM40_17290 ENOG4105K7K Transcriptional regulator XM40_17300 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) XM40_17305 ENOG4105DUM transcriptional regulator, lysR family XM40_17310 ENOG4105HMI Membrane XM40_17315 ENOG4108IJ2 phosphate acetyltransferase XM40_17320 ENOG4107JTW chlorite dismutase XM40_17330 ENOG4105CHM Aminotransferase XM40_17360 ENOG4105FCW Major Facilitator superfamily XM40_17365 ENOG4105C2C drug resistance transporter, Bcr CflA XM40_17380 ENOG4105C26 Dehydrogenase XM40_17385 ENOG4105D82 Glutamate dehydrogenase XM40_17395 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase XM40_17400 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase XM40_17405 ENOG4105C1B dTDP-glucose 4-6-dehydratase XM40_17410 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) XM40_17415 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG XM40_17420 ENOG4107TY6 Acylneuraminate cytidylyltransferase XM40_17430 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD XM40_17435 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase XM40_17470 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) XM40_17475 ENOG4108RJ9 Glycosyl transferase, family 2 XM40_17495 ENOG4105DWF phosphomethylpyrimidine kinase XM40_17510 ENOG4105C5Y PTS System XM40_17525 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin XM40_17530 ENOG4105DEN Luciferase family XM40_17535 ENOG4108DBC nitroreductase XM40_17540 ENOG4105C19 ABC transporter XM40_17565 ENOG4105I4A GCN5-related N-acetyltransferase XM40_17585 ENOG4105BZ9 Cytochrome C oxidase, subunit I XM40_17590 ENOG4105E2S oxidase) subunit II XM40_17595 ENOG4107BMA Transglycosylase associated protein XM40_17605 ENOG4105WH5 Teichoic acid glycosylation protein XM40_17630 ENOG4107ZXU DSBA oxidoreductase XM40_17635 ENOG4105DBE peroxidase XM40_17640 ENOG410650H (LipO)protein XM40_17645 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) XM40_17650 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase XM40_17655 ENOG4105CMU LysR family (Transcriptional regulator XM40_17660 ENOG4105VAW lrga family XM40_17665 ENOG41067MG lrgb family XM40_17675 ENOG4107TXC Transcriptional regulator XM40_17680 ENOG4105DR4 Methyltransferase XM40_17690 ENOG4105CK1 PTS System XM40_17695 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin XM40_17700 ENOG4105X1N Glycosyl transferase family 8 XM40_17710 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase XM40_17720 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) XM40_17725 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein XM40_17730 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) XM40_17735 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD XM40_17740 ENOG4105CM2 brancheD-chain amino acid aminotransferase XM40_17745 ENOG4105F8D glycoside hydrolase family 4 XM40_17750 ENOG4105VCP PTS System XM40_17755 ENOG4105CK1 PTS System XM40_17760 ENOG4105VZJ PTS System XM40_17765 ENOG4105EMD TRANSCRIPTIONal XM40_17775 ENOG4105DQ5 transport system permease protein XM40_17780 ENOG4105EHG Permease protein XM40_17790 ENOG41082YX Transcriptional regulator, arsr family XM40_17795 ENOG4107R5R arsenical pump membrane protein XM40_17800 ENOG4105VZJ PTS System XM40_17805 ENOG4105VCP PTS System XM40_17810 ENOG4105CK1 PTS System XM40_17815 ENOG4105CS2 ec 3.2.1.21 XM40_17820 ENOG4105EVU fructokinase XM40_17825 ENOG4105DG6 mannose-6-phosphate isomerase XM40_17835 ENOG4105CH6 catalase XM40_17840 ENOG4107QHE Choloylglycine hydrolase XM40_17845 ENOG4105ETS cytosine purines uracil thiamine allantoin XM40_17850 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) XM40_17855 ENOG4108JJ8 (ABC) transporter XM40_17860 ENOG4108JJ9 ABC, transporter XM40_17865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii XM40_17870 ENOG4105C4M (Ubiquinol oxidase) subunit I XM40_17875 ENOG4105D2K citrate carrier protein XM40_17880 ENOG4107BJW polysaccharide deacetylase XM40_17895 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) XM40_17905 ENOG4105CMR udp-glucose 4-epimerase XM40_17910 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) XM40_17925 ENOG4105DHI Methyltransferase XM40_17950 ENOG4105CH6 catalase XM40_17955 ENOG4105D4T Citrate transporter XM40_17970 ENOG4105DEU major facilitator superfamily XM40_17975 ENOG4105C1J atp-dependent rna helicase XM40_18040 ENOG4108NR7 pectate lyase XM40_18050 ENOG4107YZX Universal stress protein XM40_18055 ENOG4105CS2 ec 3.2.1.21 XM40_18060 ENOG4105C5Y PTS System XM40_18075 ENOG4106Z5D Glycoside Hydrolase Family 43 XM40_18085 ENOG4105C84 Histidine ammonia-lyase XM40_18090 ENOG4105CGP Urocanate hydratase XM40_18095 ENOG4105CI2 imidazolone-5-propionate hydrolase XM40_18100 ENOG4107W25 arginase agmatinase formiminoglutamase XM40_18110 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) XM40_18115 ENOG4105D9N nucleoside XM40_18120 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) XM40_18125 ENOG4107RHR regulatoR XM40_18130 ENOG410667J hydrolase XM40_18160 ENOG4108V5C ABC transporter XM40_18195 ENOG4105WZ4 isomerase XM40_18200 ENOG4105F0H myo-inositol catabolism protein XM40_18205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) XM40_18215 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) XM40_18225 ENOG4105EDK PfkB domain protein XM40_18235 ENOG4105C26 Dehydrogenase XM40_18245 ENOG4105CPC Aldo Keto reductase XM40_18250 ENOG4107QNK )-transporter XM40_18255 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) XM40_18265 ENOG41061TZ Short-chain dehydrogenase reductase Sdr XM40_18270 ENOG4108S01 response regulator XM40_18275 ENOG4108ZGX Histidine kinase XM40_18280 ENOG4105ECK Fatty Acid Desaturase XM40_18290 ENOG4105ST3 Transcriptional regulator XM40_18295 ENOG4105C26 Dehydrogenase XM40_18300 ENOG4108ITS PQQ enzyme repeat XM40_18310 ENOG4105WAB arsR family transcriptional regulator XM40_18315 ENOG4105F27 Major Facilitator XM40_18320 ENOG41085PJ rdd domain containing protein XM40_18330 ENOG4105D3R alkyl hydroperoxide reductase XM40_18335 ENOG4108JU3 Alkyl hydroperoxide reductase XM40_18340 ENOG4105C85 amino acid XM40_18345 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 XM40_18350 ENOG4108XHQ (2Fe-2S)-binding domain protein XM40_18370 ENOG4105XRQ Xanthine dehydrogenase accessory factor XM40_18390 ENOG4107QJE Chromosome Partitioning Protein XM40_18395 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) XM40_18410 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) XM40_18415 ENOG4105CPC Aldo Keto reductase XM40_18420 ENOG4105WQG acetyltransferase XM40_18430 ENOG41066UZ arginase EC 3.5.3.1 XM40_18435 ENOG4108IQI permease XM40_18440 ENOG4105C8Y Acetylornithine aminotransferase XM40_18450 ENOG41082BM Transcriptional regulator, arsr family XM40_18455 ENOG4108JUB Transcriptional regulator XM40_18465 ENOG4105C5H ABC transporter XM40_18480 ENOG4105D06 uba thif-type nad fad binding protein XM40_18485 ENOG4105BZU Histidine kinase XM40_18495 ENOG4105C0H protease XM40_18500 ENOG4105Q2H domain protein XM40_18515 ENOG4105BZU Histidine kinase XM40_18520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XM40_18550 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis XM40_18555 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase XM40_18560 ENOG4105CDU Replicative dna helicase XM40_18580 ENOG4107QPH glycogen) synthase XM40_18590 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR XM40_18595 ENOG4105CPK Glycosyl transferase (Group 1 XM40_18615 ENOG4105BZR domain protein XM40_18620 ENOG4108XMW Membrane XM40_18635 ENOG4105KVH Transcriptional regulator XM40_18640 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase XM40_18645 ENOG4108UZ3 Transporter XM40_18650 ENOG4105EDQ levansucrase EC 2.4.1.10 XM40_18655 ENOG4108HKT sucrose-6-phosphate hydrolase XM40_18660 ENOG4107XBN GntR Family Transcriptional Regulator XM40_18680 ENOG4108TVJ Nitroreductase XM40_18685 ENOG4105FS7 Transcriptional regulator XM40_18695 ENOG4108U05 Transcriptional regulator XM40_18710 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase XM40_18715 ENOG4105CMU LysR family (Transcriptional regulator XM40_18720 ENOG4105DTD Dehydrogenase XM40_18730 ENOG4107Y9U Membrane XM40_18750 ENOG4105C7Z Conserved Protein XM40_18755 ENOG4107FCW Abortive infection protein XM40_18765 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase XM40_18775 ENOG4105CGK Exodeoxyribonuclease III XM40_18780 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) XM40_18790 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) XM40_18795 ENOG4108UUM single-stranded DNA-binding protein XM40_18800 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) XM40_18805 ENOG4105C3G gtp-binding protein XM40_18810 ENOG4108J2R molybdopterin oxidoreductase XM40_18815 ENOG4105VDK protein, conserved in bacteria XM40_18830 ENOG4108ZDA Sporulation protein YyaC XM40_18835 ENOG4105FA0 parb-like partition protein XM40_18840 ENOG4107QJE Chromosome Partitioning Protein XM40_18855 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) XM40_18860 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) XM40_18875 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) XM40_18880 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) XM40_18885 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) XM40_18890 ENOG410848D S4 domain protein YaaA XM40_18895 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) XM40_18905 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) XM40_18910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)