locus-tag class description U722_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) U722_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) U722_00015 ENOG410848D S4 domain protein YaaA U722_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) U722_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U722_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U722_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) U722_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) U722_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) U722_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) U722_00095 ENOG4105BZW Glycerate kinase U722_00110 ENOG4105ZMH deoxynucleoside kinase U722_00125 ENOG4105VRS hydrolase family 18 U722_00130 ENOG4105GTG Isochorismatase U722_00135 ENOG4108Z6B deaminase U722_00140 ENOG4105C6E dna polymerase iii U722_00145 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) U722_00150 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) U722_00160 ENOG41067KS pro-sigma K processing U722_00200 ENOG4105CDW Resistance protein U722_00205 ENOG4105CXN decarboxylase U722_00210 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) U722_00215 ENOG4105X0R protein from nitrogen regulatory protein P-II U722_00220 ENOG4105XVJ Protein of unknown function (DUF327) U722_00225 ENOG4105FA2 dna polymerase iii U722_00230 ENOG4105MA4 psp1 domain protein U722_00240 ENOG41060K3 Methyltransferase U722_00245 ENOG4105VC4 domain protein U722_00250 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) U722_00255 ENOG4105KRN Transcriptional regulator, abrb family U722_00260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) U722_00265 ENOG4105F8V Hydrolase, tatD family U722_00270 ENOG41069ER domain protein U722_00280 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) U722_00285 ENOG4105XFA sporulation peptidase YabG U722_00290 ENOG4105W42 Veg protein U722_00295 ENOG4105XEW small acid-soluble spore protein U722_00300 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) U722_00305 ENOG4105DFT pur operon repressor U722_00310 ENOG4105KME endoribonuclease L-psp U722_00315 ENOG4105K4W Could be involved in septation (By similarity) U722_00320 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) U722_00325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase U722_00330 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) U722_00345 ENOG4108JA2 transcriptioN-repair coupling factor U722_00350 ENOG4108M14 stage v sporulation protein t U722_00360 ENOG4108IY2 MazG family U722_00365 ENOG41082I2 s4 domain protein U722_00370 ENOG4105VYY sporulation protein yabp U722_00385 ENOG41060GV RNA binding s1 domain protein U722_00415 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) U722_00420 ENOG4108UGV hypoxanthine phosphoribosyltransferase U722_00425 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) U722_00430 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) U722_00435 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) U722_00440 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase U722_00445 ENOG4105C6T cysteine synthase U722_00450 ENOG4105CRQ synthase (Component I) U722_00455 ENOG4105DDQ anthranilate synthase U722_00465 ENOG4105EEI dihydropteroate synthase U722_00470 ENOG4105KRF dihydroneopterin aldolase U722_00475 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase U722_00485 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) U722_00490 ENOG4105CRK lysyL-tRNA synthetase U722_00555 ENOG4108Z0C Uvrb UvrC protein U722_00560 ENOG41066A3 ATP guanido phosphotransferase U722_00570 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) U722_00575 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) U722_00580 ENOG4105CTP PilT protein domain protein U722_00585 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) U722_00590 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) U722_00595 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) U722_00600 ENOG4105D7W serine acetyltransferase U722_00610 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) U722_00615 ENOG4105C2N RNA methyltransferase TrmH family group 3 U722_00620 ENOG4105M0M Tetracycline resistance protein U722_00640 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) U722_00645 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) U722_00655 ENOG4108VZM 50s ribosomal protein L10 U722_00660 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) U722_00665 ENOG4107Y49 methyltransferase U722_00670 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) U722_00675 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) U722_00680 ENOG4105XPM ribosomal protein U722_00685 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) U722_00690 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) U722_00695 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) U722_00700 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) U722_00705 ENOG4107SKW Inherit from COG: Alpha beta hydrolase U722_00710 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) U722_00715 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) U722_00720 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) U722_00725 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) U722_00730 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity U722_00735 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) U722_00740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) U722_00745 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) U722_00750 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) U722_00755 ENOG41082SA 50s ribosomal protein l29 U722_00760 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal U722_00765 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) U722_00775 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits U722_00785 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) U722_00790 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) U722_00795 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) U722_00800 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) U722_00805 ENOG4105VPB 50S ribosomal protein L30 U722_00810 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) U722_00815 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) U722_00820 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) U722_00825 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) U722_00830 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) U722_00840 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits U722_00845 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) U722_00850 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) U722_00855 ENOG4108ZT0 50S ribosomal protein l17 U722_00860 ENOG4108JJB ABC transporter U722_00865 ENOG4108JJB ABC transporter U722_00870 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) U722_00875 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) U722_00880 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) U722_00885 ENOG4108UJD 30S ribosomal protein S9 U722_00890 ENOG4108I0C methyltransferase U722_00910 ENOG4105D1F ATP-binding protein U722_00925 ENOG4108NMV polysaccharide deacetylase U722_01050 ENOG4108JPW Aminotransferase U722_01065 ENOG4105CHH sulfate transporter U722_01075 ENOG4108SA1 esterase U722_01095 ENOG410874W AraC family transcriptional regulator U722_01100 ENOG4105EHZ conserved protein UCP016719 U722_01105 ENOG4105D17 glycoside hydrolase, family 3 domain protein U722_01120 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate U722_01130 ENOG4105EWC Purine nucleoside phosphorylase U722_01160 ENOG4105EMN RNA polymerase sigma factor U722_01170 ENOG4105C8B TIGR00159 family U722_01175 ENOG4107U5W ybbr family U722_01180 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) U722_01205 ENOG4106K80 U722_01215 ENOG41067MG lrgb family U722_01225 ENOG41061AU MarR family Transcriptional regulator U722_01240 ENOG4105BZU Histidine kinase U722_01245 ENOG4105WH1 Two component transcriptional regulator luxr family U722_01250 ENOG4105CJ1 ABC, transporter U722_01285 ENOG4105C0W non-ribosomal peptide synthetase U722_01290 ENOG4105C0W non-ribosomal peptide synthetase U722_01315 ENOG4106DDH Sporulation-specific SASP protein U722_01330 ENOG4107QTZ amino acid U722_01340 ENOG4107VXM glycerophosphoryl diester phosphodiesterase U722_01345 ENOG4105CXY transporter U722_01380 ENOG4107SCQ Iron-containing alcohol dehydrogenase U722_01385 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR U722_01390 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase U722_01395 ENOG4107ZTW SNARE associated Golgi U722_01410 ENOG4105C72 UPF0176 protein U722_01425 ENOG4105CM2 brancheD-chain amino acid aminotransferase U722_01430 ENOG4108IQI permease U722_01435 ENOG4108J5H Homocysteine s-methyltransferase U722_01445 ENOG4105CSV Glutaminase U722_01470 ENOG41076HS cation diffusion facilitator family transporter U722_01475 ENOG4108TVJ Nitroreductase U722_01480 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase U722_01485 ENOG4108VGI doxx family U722_01490 ENOG4105XXY Thioredoxin U722_01510 ENOG4105DGI Alkaline phosphatase U722_01515 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) U722_01520 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) U722_01525 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) U722_01530 ENOG4107EPV Aminotransferase class V U722_01535 ENOG4105C0R drug resistance transporter emrb qaca subfamily U722_01540 ENOG4105J7D transcriptional regulator U722_01550 ENOG4107RB3 L-asparaginase U722_01555 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold U722_01560 ENOG41060AI SEC-C motif U722_01565 ENOG4107SET aldo keto reductase U722_01595 ENOG4105H9W Short-chain dehydrogenase reductase Sdr U722_01605 ENOG4105DSE periplasmic solute binding protein U722_01610 ENOG4105DIK (ABC) transporter U722_01620 ENOG4105DEN Luciferase family U722_01625 ENOG4108N0M stress protein U722_01630 ENOG4106FN3 tellurium resistance protein U722_01635 ENOG4106FN3 tellurium resistance protein U722_01640 ENOG4107TS3 membrane protein, TerC U722_01645 ENOG4108TTB tellurium resistance protein U722_01655 ENOG41079KZ Major Facilitator Superfamily U722_01660 ENOG4108IJ7 Glycine betaine U722_01665 ENOG4107SQ8 Glycine betaine U722_01695 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) U722_01725 ENOG4105EIG urea carboxylase-associated protein 1 U722_01730 ENOG4107RA1 nh(3)-dependent nad( ) synthetase U722_01740 ENOG4105I1F Resistance protein U722_01750 ENOG4105DJB Major Facilitator Superfamily U722_01755 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) U722_01760 ENOG4105I82 acetyl xylan esterase U722_01765 ENOG410756H nucleotidyltransferase U722_01775 ENOG4105C26 Dehydrogenase U722_01780 ENOG4105CK7 Sodium proline symporter U722_01785 ENOG4107YHD transcriptional regulator U722_01790 ENOG4105CAY ferredoxin--nadp reductase U722_01795 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) U722_01800 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit U722_01805 ENOG4108IFG nitrite reductase, (NAD(P)H) U722_01815 ENOG4105CKI cobalamin synthesis protein U722_01820 ENOG4105E2A Dehydrogenase U722_01825 ENOG4105HHM rdd domain containing protein U722_01840 ENOG4105CS2 ec 3.2.1.21 U722_01855 ENOG41080HJ 6-phospho 3-hexuloisomerase U722_01860 ENOG4108VA3 3-hexulose-6-phosphate synthase U722_01865 ENOG4105KVH Transcriptional regulator U722_01895 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) U722_01910 ENOG4105CDA abc transporter atp-binding protein U722_01915 ENOG4105DRP amino acid AbC transporter U722_01925 ENOG4106P55 Transcriptional regulator U722_01930 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase U722_01935 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) U722_01940 ENOG41069ZX U722_01945 ENOG41069ZX U722_01950 ENOG4105DUX Transporter U722_01965 ENOG4105E1K spore germination protein U722_01980 ENOG4105CPU Monooxygenase U722_01985 ENOG4108XSB acetyltransferase, (GNAT) family U722_01990 ENOG4105EAB amino acid AbC transporter U722_01995 ENOG4108HW4 amino acid AbC transporter U722_02005 ENOG4105CH2 amidohydrolase U722_02010 ENOG4108PGP mmge prpd family protein U722_02020 ENOG4107WD8 ABC transporter, permease U722_02025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U722_02030 ENOG4105BZU Histidine kinase U722_02050 ENOG4105CFH Aspartokinase U722_02055 ENOG4105DHS permease protein U722_02060 ENOG4105CM4 permease protein U722_02065 ENOG4108IPW abc transporter atp-binding protein U722_02080 ENOG4105R8C Transcriptional regulator U722_02085 ENOG4108DBC nitroreductase U722_02090 ENOG41067V3 Antibiotic biosynthesis monooxygenase U722_02095 ENOG4105YVS arsR family transcriptional regulator U722_02105 ENOG4108JPW Aminotransferase U722_02110 ENOG4105C26 Dehydrogenase U722_02125 ENOG4105H9W Short-chain dehydrogenase reductase Sdr U722_02130 ENOG4105KTB nuclear export factor GLE1 U722_02135 ENOG4108T5E Copper resistance protein U722_02140 ENOG4108ZYE Transcriptional regulator U722_02160 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase U722_02180 ENOG4105E7W lamb ycsf family protein U722_02185 ENOG4105C5A transporter U722_02190 ENOG4105CFM UPF0317 protein U722_02195 ENOG4105P4J Allophanate hydrolase, subunit 1 U722_02205 ENOG4107258 Transcriptional regulator U722_02210 ENOG4105XJB lipolytic protein G-D-S-L family U722_02220 ENOG41061CK Antibiotic biosynthesis monooxygenase U722_02225 ENOG4107RVG penicillin-binding protein U722_02230 ENOG4107QM2 Aldo Keto reductase U722_02235 ENOG4105ETD TRANSCRIPTIONal U722_02245 ENOG4105CYX Short-chain dehydrogenase reductase Sdr U722_02260 ENOG410606W general stress protein U722_02270 ENOG4105VCH membrane U722_02280 ENOG4105C9U ATP-dependent DNA helicase RecQ U722_02295 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) U722_02300 ENOG4107R8N Glycosyl transferase, family 2 U722_02310 ENOG4105C0X amino acid U722_02350 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) U722_02365 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) U722_02370 ENOG4105RXJ U722_02375 ENOG4105KPY Small multidrug resistance protein U722_02380 ENOG4105EU9 U722_02385 ENOG4105QVS general stress protein U722_02390 ENOG41082W1 Cupin 2, conserved barrel domain protein U722_02405 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit U722_02410 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism U722_02415 ENOG4108MRH transcriptional regulatory protein U722_02420 ENOG4107QJT sodium dicarboxylate symporter U722_02425 ENOG4106F5Q Membrane U722_02430 ENOG4105CJ1 ABC, transporter U722_02445 ENOG4105FDT acyl-CoA dehydrogenase U722_02465 ENOG4105SZ6 Thioredoxin U722_02470 ENOG4105CPF Cell wall formation (By similarity) U722_02475 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) U722_02485 ENOG4105C1J atp-dependent rna helicase U722_02490 ENOG410905X membrane-flanked domain protein U722_02495 ENOG4105CKV Membrane U722_02505 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) U722_02510 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein U722_02515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) U722_02525 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) U722_02530 ENOG4107MMM Anti-sigma-factor antagonist U722_02535 ENOG4105FUA antagonist U722_02540 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase U722_02545 ENOG4107SGM protein serine threonine phosphatase U722_02550 ENOG4105WN5 stage II sporulation protein U722_02555 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) U722_02565 ENOG41064BQ Phosphatase U722_02580 ENOG410906U SprT-like U722_02620 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein U722_02630 ENOG4105CSH Transporter U722_02645 ENOG4105K56 Transcriptional regulator U722_02655 ENOG4108Z40 Transcriptional regulator U722_02660 ENOG4108RYK Nad-dependent epimerase dehydratase U722_02665 ENOG4105VEQ Cold shock protein U722_02670 ENOG4108VJ1 Transcriptional regulator (CarD family U722_02675 ENOG4105XTG Pfam:DUF156 U722_02680 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase U722_02690 ENOG4105VFE sira family U722_02695 ENOG4107TPS domain protein U722_02700 ENOG4105VFE sira family U722_02705 ENOG41087NI Sulfite exporter TauE/SafE U722_02730 ENOG4105IRW patatin-like phospholipase family protein U722_02740 ENOG4107RCH Diaminopropionate ammonia-lyase U722_02745 ENOG4108WYP Transcriptional regulator U722_02750 ENOG4105KME endoribonuclease L-psp U722_02755 ENOG4105C44 Serine transporter U722_02760 ENOG4105CH2 amidohydrolase U722_02765 ENOG4108MCI Transcriptional regulator, ARAC family U722_02770 ENOG4105CE7 Amidase, hydantoinase carbamoylase family U722_02775 ENOG4107U9B transcriptional regulator U722_02780 ENOG4105DXI Major Facilitator superfamily U722_02805 ENOG4105DNP FAD linked oxidase domain protein U722_02815 ENOG4105PGM cation diffusion facilitator family transporter U722_02820 ENOG4105H3G oxidoreductase U722_02830 ENOG4108U7W acetyltransferase U722_02840 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) U722_02865 ENOG4105DQ4 alcohol dehydrogenase U722_02870 ENOG4105VUF Transcriptional regulator U722_02880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family U722_02895 ENOG4105EQ0 Major Facilitator superfamily U722_02900 ENOG4108JGH Tetr family transcriptional regulator U722_02915 ENOG4105E2A Dehydrogenase U722_02920 ENOG4105PGS Spore coat protein U722_02930 ENOG4105ENE Histidine kinase U722_02935 ENOG4108VB1 regulatoR U722_02940 ENOG4105EYF MMPL domain protein U722_02960 ENOG4108JYZ YitT family U722_02970 ENOG4105C2C drug resistance transporter, Bcr CflA U722_02975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U722_02995 ENOG41090E6 transcriptional regulator MERR family U722_03010 ENOG4105F2W methyltransferase U722_03015 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) U722_03040 ENOG4105FQP Beta-lactamase U722_03050 ENOG41090UD (LipO)protein U722_03055 ENOG4108SUT Major Facilitator Superfamily U722_03060 ENOG4108TZY GntR Family Transcriptional Regulator U722_03065 ENOG4105JXH GntR family transcriptional regulator U722_03070 ENOG4105DJ2 Major Facilitator Superfamily U722_03090 ENOG4107QTZ amino acid U722_03110 ENOG4107QNK )-transporter U722_03155 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) U722_03160 ENOG4105K8N protein family UPF0079, ATPase U722_03165 ENOG41072GX Peptidase M22 Glycoprotease U722_03170 ENOG410801F ribosomal-protein-alanine acetyltransferase U722_03175 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) U722_03180 ENOG4105C5H ABC transporter U722_03185 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U722_03190 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) U722_03195 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) U722_03200 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) U722_03210 ENOG4108TYN CAAX amino terminal protease family protein U722_03215 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) U722_03220 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) U722_03235 ENOG4105PGZ NB-ARC domain U722_03240 ENOG4105CPQ Dehydrogenase U722_03245 ENOG4105CT4 transporter U722_03260 ENOG41087YS Phage shock protein A U722_03265 ENOG4105DQX Zinc finger domain U722_03270 ENOG4108WV1 Pfam:DUF477 U722_03280 ENOG4105EXC Acyl-transferase U722_03290 ENOG4108P49 AntiSigma factor U722_03295 ENOG4105JVQ RNA Polymerase U722_03325 ENOG4107STQ Multicopper oxidase U722_03330 ENOG4105C85 amino acid U722_03335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 U722_03350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) U722_03365 ENOG4105C7N Xanthine uracil vitamin C permease U722_03390 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) U722_03395 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit U722_03400 ENOG4105C83 adenylosuccinate lyase U722_03405 ENOG4105C8V SAICAR synthetase U722_03410 ENOG4105VR9 phosphoribosylformylglycinamidine synthase U722_03415 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I U722_03420 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii U722_03430 ENOG4105CXB phosphoribosylaminoimidazole synthetase U722_03435 ENOG4108V3E phosphoribosylglycinamide formyltransferase U722_03440 ENOG4105DC1 bifunctional purine biosynthesis protein purh U722_03445 ENOG4105C12 Phosphoribosylglycinamide synthetase U722_03460 ENOG4108R5T secreted protein U722_03465 ENOG4105KGF protein, YerC YecD U722_03470 ENOG4105CBC glutamate synthase U722_03485 ENOG4105C4R Atp-dependent dna helicase U722_03490 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) U722_03500 ENOG4105CRN Aminoglycoside phosphotransferase U722_03505 ENOG4105KT7 mgtC SapB transporter U722_03510 ENOG4105CK7 Sodium proline symporter U722_03515 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) U722_03520 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) U722_03525 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) U722_03530 ENOG4108IG5 Transcriptional regulator U722_03540 ENOG4105CBD Diacylglycerol kinase U722_03545 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) U722_03555 ENOG4105CJ1 ABC, transporter U722_03585 ENOG4105CDY transcriptional regulatory protein U722_03595 ENOG41075D4 Aminoglycoside 6-adenylyltransferase U722_03610 ENOG4105WEF catalase U722_03615 ENOG4105M18 -acetyltransferase U722_03625 ENOG4105H67 Protein of unknown function (DUF421) U722_03630 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) U722_03635 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily U722_03660 ENOG4106I4J membrane U722_03665 ENOG41082F9 transcriptional regulator U722_03670 ENOG41061H0 Monooxygenase U722_03675 ENOG4108R1P U722_03680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) U722_03690 ENOG4105E0M Sulfatase U722_03695 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase U722_03705 ENOG41090R9 glycosyltransferase U722_03710 ENOG4107R51 Glycosyl transferase, family 2 U722_03715 ENOG41090R9 glycosyltransferase U722_03720 ENOG4105EU0 Major facilitator Superfamily U722_03725 ENOG4105CUB amino acid U722_03730 ENOG4105C26 Dehydrogenase U722_03735 ENOG4105FKZ Methyl-accepting chemotaxis U722_03740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr U722_03745 ENOG4107TVC Glycosyl transferase, family 2 U722_03750 ENOG4105C5H ABC transporter U722_03755 ENOG4107SWG transcriptional regulator MERR family U722_03760 ENOG4105DXB Major Facilitator superfamily U722_03765 ENOG4105C5H ABC transporter U722_03770 ENOG4105FDU atp-dependent rna helicase U722_03780 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein U722_03795 ENOG4108J20 pectate lyase U722_03800 ENOG4107QPK )-transporter U722_03870 ENOG4108VAC response regulator U722_03880 ENOG4108Z6X (sortase) family U722_03890 ENOG4108MRH transcriptional regulatory protein U722_03915 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) U722_03920 ENOG4108RPX mosc domain containing protein U722_03940 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) U722_03980 ENOG4105C5Y PTS System U722_03985 ENOG4105CG3 alpha amylase, catalytic region U722_03990 ENOG4107414 GntR family transcriptional regulator U722_03995 ENOG4108RCM Nitroreductase U722_04010 ENOG4105CGH 5'-nucleotidase U722_04015 ENOG4107RKG DJ-1/PfpI family U722_04020 ENOG4105ETE Transcriptional regulator (LacI family U722_04025 ENOG4105E2X shikimate dehydrogenase U722_04030 ENOG4105FF2 Type I DHQase U722_04045 ENOG4105KJF protein tyrosine phosphatase U722_04055 ENOG4107U9T Pfam:Ribonuclease_BN U722_04065 ENOG4108ISG Major Facilitator U722_04070 ENOG4105UPD Calcium Proton U722_04080 ENOG4105D8X mechanosensitive ion channel U722_04100 ENOG4106KE4 Dehydrogenase U722_04110 ENOG4105D7N magnesium and cobalt transport protein CorA U722_04120 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) U722_04140 ENOG4107RUY (E1 component), alpha subunit U722_04150 ENOG4107QKR Dehydrogenase U722_04160 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family U722_04170 ENOG4105F8D glycoside hydrolase family 4 U722_04175 ENOG4108Q3X Transcriptional regulator U722_04180 ENOG4105CI1 PTS System U722_04185 ENOG4105BZ1 (ABC) transporter U722_04190 ENOG4105BZ1 (ABC) transporter U722_04200 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase U722_04205 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) U722_04210 ENOG4105U3E Transcriptional regulator U722_04220 ENOG4105DYS nad(p)h dehydrogenase (quinone) U722_04225 ENOG4105H93 Acyltransferase family U722_04240 ENOG4108YYS metal-dependent hydrolase (By similarity) U722_04245 ENOG4105C0R drug resistance transporter emrb qaca subfamily U722_04250 ENOG410834F Transcriptional regulator U722_04260 ENOG4105JAB phenazine biosynthesis protein, phzf family U722_04265 ENOG4107Y03 Nitroreductase U722_04280 ENOG4105ECP epimerase U722_04285 ENOG410902V Modulates RecA activity (By similarity) U722_04295 ENOG4105F27 Major Facilitator U722_04305 ENOG4108TCS Glutamyl endopeptidase U722_04325 ENOG4106AKJ U722_04330 ENOG4105D74 hydrolase U722_04335 ENOG4105CKK Glycosyl transferase, family 2 U722_04340 ENOG4105EJV Membrane U722_04345 ENOG41067AE Membrane-bound metal-dependent hydrolase U722_04350 ENOG4105CEN a g-specific adenine glycosylase U722_04355 ENOG4106BXE U722_04360 ENOG4105CAN Short-chain dehydrogenase reductase Sdr U722_04380 ENOG4105BZ1 (ABC) transporter U722_04385 ENOG4107NBY Membrane U722_04390 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase U722_04395 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U722_04400 ENOG4105G5W regulator Fur family U722_04405 ENOG4105TUA UPF0295 protein U722_04525 ENOG4105EC3 peptidase S51, dipeptidase E U722_04530 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) U722_04535 ENOG4105DNP FAD linked oxidase domain protein U722_04545 ENOG4105DEF Extracellular solute-binding protein, family 5 U722_04555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component U722_04560 ENOG4105C3U ABC transporter U722_04565 ENOG4108JQ7 (ABC) transporter U722_04580 ENOG4105E2Y ABC, transporter U722_04585 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein U722_04590 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component U722_04605 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) U722_04610 ENOG4107D63 U722_04615 ENOG4105VZ8 Transcriptional regulator U722_04630 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) U722_04640 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) U722_04665 ENOG4105CYN Serine protein kinase U722_04675 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes U722_04680 ENOG4105CW7 secretion protein, HlyD family U722_04685 ENOG4105C0R drug resistance transporter emrb qaca subfamily U722_04690 ENOG4105CS1 NAD(P)H quinone oxidoreductase U722_04705 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family U722_04710 ENOG4105CZV ABC transporter U722_04715 ENOG4105CJ1 ABC, transporter U722_04720 ENOG4108TU7 Inherit from COG: (ABC) transporter U722_04725 ENOG4105VEQ Cold shock protein U722_04735 ENOG4105BZU Histidine kinase U722_04775 ENOG4108YBP pseudouridine synthase U722_04785 ENOG41080XP Cbs domain U722_04790 ENOG4107YBY Hydrolase U722_04795 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase U722_04800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) U722_04805 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator U722_04815 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) U722_04820 ENOG4105C6V Glycerol-3-phosphate dehydrogenase U722_04830 ENOG4105BZU Histidine kinase U722_04835 ENOG4105WH1 Two component transcriptional regulator luxr family U722_04875 ENOG4105ED1 spovr family U722_04880 ENOG4105G6Z alkaline phosphatase U722_04895 ENOG4105BZN citrate synthase U722_04900 ENOG4105CYX Short-chain dehydrogenase reductase Sdr U722_04905 ENOG4105CUB amino acid U722_04910 ENOG4105C8J )-transporter U722_04920 ENOG4105J37 U722_04925 ENOG4108AEY RNA polymerase sigma factor U722_04930 ENOG4105F6E Acyl-transferase U722_04935 ENOG4105C37 (CBS) domain U722_04945 ENOG4105CHM Aminotransferase U722_04950 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase U722_04955 ENOG4105C37 (CBS) domain U722_04965 ENOG4105WMR Protein CrcB homolog U722_04970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase U722_04980 ENOG4105D64 Mechanosensitive ion channel U722_04985 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) U722_04990 ENOG4107VMI polysaccharide deacetylase U722_04995 ENOG4105F0I Aminotransferase U722_05000 ENOG4105W1N transcriptional regulator U722_05005 ENOG4105IIP Membrane U722_05025 ENOG4105BZ1 (ABC) transporter U722_05030 ENOG4105BZ1 (ABC) transporter U722_05055 ENOG410839P U722_05065 ENOG4106MP8 UPF0754 membrane protein U722_05070 ENOG4105WZB UPF0342 protein U722_05075 ENOG4105F1N DNA alkylation repair U722_05085 ENOG4105D4P Coproporphyrinogen iii oxidase U722_05095 ENOG4107S91 Sodium hydrogen exchanger U722_05100 ENOG4105NCW Trka-c domain protein U722_05110 ENOG4105CGU Enoyl-CoA hydratase U722_05120 ENOG4108IUX (ABC) transporter U722_05125 ENOG4105RHA ABC transporter, permease U722_05130 ENOG4107VRP DNA repair exonuclease U722_05135 ENOG4106D4I domain protein U722_05140 ENOG4105EQI Metal Dependent Phosphohydrolase U722_05150 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) U722_05200 ENOG4105NBU tryptophan transport protein U722_05205 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) U722_05210 ENOG4105K59 histidine triad (HIT) protein U722_05240 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation U722_05245 ENOG4105BZ4 penicillin-binding protein U722_05250 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) U722_05255 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) U722_05260 ENOG4105C1Q protoporphyrinogen oxidase U722_05270 ENOG4105ECB domain protein U722_05285 ENOG4105DER m42 family U722_05295 ENOG4106AXD U722_05300 ENOG4108RQ5 Beta-lactamase domain-containing protein U722_05305 ENOG4105DF9 Lipoate-protein, ligase U722_05315 ENOG4105CEY Amp-dependent synthetase and ligase U722_05325 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 U722_05340 ENOG4108HUF Transporter U722_05345 ENOG4107TB6 phosphoglycerate mutase U722_05355 ENOG4107F3J Amp-dependent synthetase and ligase U722_05360 ENOG4107ZYJ bioY protein U722_05365 ENOG4106YBV Methyl-accepting chemotaxis U722_05385 ENOG4105XVF Competence transcription factor U722_05395 ENOG4108ZMX Domain of unknown function (DU1801) U722_05405 ENOG4105X3H Excalibur domain protein U722_05410 ENOG4105K8R UPF0145 protein U722_05415 ENOG4105E1V na solute symporter U722_05420 ENOG4106CAD Protein of unknown function (DUF3311) U722_05425 ENOG41060YP U722_05445 ENOG4107SCK Monooxygenase U722_05450 ENOG4108INS Transcriptional regulator U722_05455 ENOG4108KK1 membrane protein AbrB duplication U722_05465 ENOG4108IG5 Transcriptional regulator U722_05475 ENOG4108QY0 Membrane U722_05480 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination U722_05485 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation U722_05495 ENOG4105EYH Exonuclease U722_05540 ENOG4105ERH Fumarylacetoacetate hydrolase U722_05560 ENOG4105CAQ asparagine synthetase U722_05570 ENOG4105UQX Mate efflux family protein U722_05575 ENOG4106HBX Transcriptional Regulator AraC Family U722_05580 ENOG4105ETE Transcriptional regulator (LacI family U722_05590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) U722_05595 ENOG4105SF0 DinB family U722_05600 ENOG4105MYW Pentapeptide repeat protein U722_05605 ENOG4105MA6 gCN5-related N-acetyltransferase U722_05615 ENOG4108VPT UPF0234 protein U722_05620 ENOG4105QNR S1 RNA binding domain protein U722_05625 ENOG4105DIH basic membrane U722_05630 ENOG4105C8Q Methyl-accepting chemotaxis U722_05640 ENOG4105EPR degv family U722_05645 ENOG4107AYK membrAne U722_05655 ENOG41073B9 U722_05665 ENOG4108KP7 hydrolase U722_05670 ENOG4108MXZ Esterase U722_05675 ENOG4105VG1 fes assembly suf system protein U722_05680 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) U722_05690 ENOG4105IQ5 FAD linked oxidase domain protein U722_05700 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase U722_05710 ENOG4105CAS nag kinase U722_05715 ENOG4105C8Y Acetylornithine aminotransferase U722_05720 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain U722_05730 ENOG4105DBV ornithine carbamoyltransferase U722_05760 ENOG4107RMD Basic membrane lipoprotein U722_05775 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) U722_05780 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) U722_05790 ENOG4105C3U ABC transporter U722_05795 ENOG4108JQ7 (ABC) transporter U722_05810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component U722_05820 ENOG4105C31 Tryptophanyl-tRNA synthetase U722_05825 ENOG4108J59 Extracellular solute-binding protein, family 5 U722_05830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component U722_05835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component U722_05845 ENOG4108JQ7 (ABC) transporter U722_05860 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) U722_05865 ENOG4108ZCF integral membrane protein U722_05870 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis U722_05885 ENOG4105DPN Oligoendopeptidase f U722_05895 ENOG4105T58 Dithiol-disulfide isomerase U722_05900 ENOG4108Z18 K06886 hemoglobin U722_05905 ENOG4105E4C Lytic transglycosylase catalytic U722_05910 ENOG4105MIX Adenylate cyclase U722_05925 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) U722_05930 ENOG4105EMS pseudouridine synthase U722_05935 ENOG4107S1Q Phosphatase U722_05945 ENOG4105ETU transcriptional activator (TenA U722_05950 ENOG4108VEU Thiamine monophosphate synthase U722_05970 ENOG4105D06 uba thif-type nad fad binding protein U722_05975 ENOG4105DWF phosphomethylpyrimidine kinase U722_05980 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH U722_05985 ENOG4107A88 U722_06040 ENOG4105ENA helicase U722_06060 ENOG4105CJ1 ABC, transporter U722_06075 ENOG4108ZMI UPF0477 protein U722_06090 ENOG4105C28 cystathionine U722_06095 ENOG4105C28 cystathionine U722_06115 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U722_06170 ENOG4108NE4 U722_06255 ENOG4106BHF U722_06265 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase U722_06300 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase U722_06305 ENOG4105CMR udp-glucose 4-epimerase U722_06310 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) U722_06315 ENOG4105CK1 PTS System U722_06320 ENOG4105VCP PTS System U722_06330 ENOG4105E98 transcriptional regulator DeoR family U722_06345 ENOG4105KT7 mgtC SapB transporter U722_06365 ENOG4108IEG Formate dehydrogenase Alpha subunit U722_06375 ENOG4106A3M Cytochrome p-450 U722_06380 ENOG41087PP glycosyltransferase MGT family U722_06390 ENOG4105EXQ uroporphyrinogen iii synthase hem4 U722_06395 ENOG4105C4B ABC transporter, permease U722_06400 ENOG4108IXI (ABC) transporter U722_06410 ENOG4105Q95 Cupin 2, conserved barrel domain protein U722_06430 ENOG4105D2H Uronic isomerase U722_06435 ENOG4105CT4 transporter U722_06440 ENOG4107KJX Transcriptional regulator U722_06445 ENOG4107QZW Altronate oxidoreductase U722_06450 ENOG4105CTX dehydratase U722_06455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U722_06460 ENOG4105F3H Histidine kinase U722_06480 ENOG4105BZU Histidine kinase U722_06485 ENOG4105WH1 Two component transcriptional regulator luxr family U722_06500 ENOG4108JJA ABC, transporter U722_06520 ENOG4107TSN permease U722_06540 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase U722_06545 ENOG4105KWG Pfam:DUF1696 U722_06550 ENOG4105K7W phage-related replication protein U722_06560 ENOG410635T phage-like element pbsx protein U722_06605 ENOG4108TFU terminase (Small subunit) U722_06610 ENOG4105IG6 Phage terminase, large subunit U722_06640 ENOG41060SN U722_06655 ENOG4105PQS phage protein U722_06660 ENOG4105FR7 XkdM protein, phage-like element PBSX U722_06665 ENOG4105MTC XkdN-like protein U722_06675 ENOG4108FKH Transglycosylase SLT domain U722_06675 ENOG4108FKH Transglycosylase SLT domain U722_06675 ENOG4108FKH Transglycosylase SLT domain U722_06680 ENOG4108WZM domain protein U722_06685 ENOG4105X7F U722_06700 ENOG4105MFU Protein of unknown function (DUF2634) U722_06705 ENOG41066EA baseplate J family protein U722_06710 ENOG410906S phage-like element pbsx protein xkdt U722_06720 ENOG41068G1 U722_06750 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase U722_06770 ENOG4105CJ3 phosphate transporter U722_06775 ENOG4107GRR phosphate transport regulator U722_06785 ENOG4107R7I amino acid U722_06795 ENOG4105EDW glycosyl transferase, family 39 U722_06800 ENOG4105CKK Glycosyl transferase, family 2 U722_06810 ENOG4105C0H protease U722_06820 ENOG4108ME1 Peptidase M55 D-aminopeptidase U722_06825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component U722_06830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component U722_06835 ENOG4105C3U ABC transporter U722_06845 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A U722_06850 ENOG4105DTQ mandelate racemase muconate lactonizing U722_06855 ENOG4107SN7 NLP P60 protein U722_06860 ENOG4108JQ7 (ABC) transporter U722_06865 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) U722_06870 ENOG4107TUM Amidinotransferase U722_06875 ENOG4108S4H thioesterase Superfamily protein U722_06885 ENOG4108428 Inherit from COG: -acetyltransferase U722_06895 ENOG41080TC multidrug resistance protein U722_06900 ENOG4105CIY formyltetrahydrofolate deformylase U722_06905 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) U722_06920 ENOG4105K56 Transcriptional regulator U722_06925 ENOG4108ZHJ Organic hydroperoxide resistance protein U722_06940 ENOG4107TVC Glycosyl transferase, family 2 U722_06950 ENOG4105D8G Major Facilitator superfamily U722_06955 ENOG4108Y4K DNA-binding transcriptional activator U722_06960 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) U722_06965 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin U722_06980 ENOG4108W7F transporter, permease U722_06985 ENOG4108JJB ABC transporter U722_06990 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein U722_06995 ENOG4105VRS hydrolase family 18 U722_07010 ENOG4105CJW magnesium transporter U722_07015 ENOG4105V75 Transcriptional regulator U722_07040 ENOG4105DQE DNA ligase U722_07045 ENOG4105FDF Could be involved in DNA repair (By similarity) U722_07055 ENOG4107T5V SNARE associated Golgi U722_07060 ENOG4107TS3 membrane protein, TerC U722_07065 ENOG4108WZW RNA polymerase sigma U722_07075 ENOG410681C small acid-soluble spore protein U722_07085 ENOG4105D0M Protease HtpX homolog U722_07095 ENOG410900G Protein of unknown function (DUF421) U722_07105 ENOG4108TGC Acyltransferase U722_07110 ENOG4105BZU Histidine kinase U722_07115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) U722_07125 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) U722_07135 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase U722_07145 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate U722_07150 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) U722_07155 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) U722_07160 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) U722_07175 ENOG4105BZU Histidine kinase U722_07180 ENOG41090MY MarR family Transcriptional regulator U722_07185 ENOG4105ER2 Ompa motb domain protein U722_07190 ENOG4105E14 MotA TolQ exbB proton channel U722_07200 ENOG4108K88 Membrane U722_07210 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) U722_07215 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase U722_07220 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) U722_07225 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) U722_07245 ENOG4105F0V Cell wall hydrolase U722_07260 ENOG4105C59 p-type ATPase U722_07265 ENOG4105DC7 peptidase M24 U722_07280 ENOG4105CID antiterminator U722_07290 ENOG4105KRI phosphocarrier protein (HPr U722_07295 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) U722_07305 ENOG4105F6S Spore photoproduct lyase U722_07310 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer U722_07315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase U722_07320 ENOG4105K4I Scp-like extracellular U722_07330 ENOG4105BZU Histidine kinase U722_07335 ENOG4105CHM Aminotransferase U722_07345 ENOG4107R88 Chemotaxis protein (CheV) U722_07350 ENOG4105UIN U722_07360 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein U722_07370 ENOG4105K6S Short-chain dehydrogenase reductase Sdr U722_07380 ENOG4105EPM Diguanylate phosphodiesterase U722_07390 ENOG4107IN1 Protein of unknown function (DUF1797) U722_07395 ENOG4108XRC Protein of unknown function (DUF458) U722_07425 ENOG4105NQC Flavodoxin U722_07445 ENOG4105D8X mechanosensitive ion channel U722_07450 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U722_07465 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) U722_07470 ENOG4105D06 uba thif-type nad fad binding protein U722_07475 ENOG4105CVM Molybdenum cofactor synthesis domain protein U722_07480 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein U722_07485 ENOG4108ZAF Molybdopterin U722_07490 ENOG41067WU Molybdopterin converting factor (Subunit 1) U722_07500 ENOG4107X8C Efflux transporter RND family MFP subunit U722_07505 ENOG4105C19 ABC transporter U722_07510 ENOG4107RBB ABC transporter, permease U722_07515 ENOG4105E98 transcriptional regulator DeoR family U722_07520 ENOG4105DE4 1-phosphofructokinase U722_07525 ENOG4105DM4 PTS System U722_07540 ENOG4105C5H ABC transporter U722_07545 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) U722_07575 ENOG4105BZU Histidine kinase U722_07585 ENOG4107ZYR domain protein U722_07590 ENOG4105CPN adenine deaminase U722_07595 ENOG4105CN5 Metallo-Beta-Lactamase U722_07600 ENOG4106148 UPF0356 protein U722_07605 ENOG4108X4Q Hydrolase U722_07610 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) U722_07625 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase U722_07630 ENOG4105C0W non-ribosomal peptide synthetase U722_07635 ENOG4107SQU synthase U722_07640 ENOG4105C0W non-ribosomal peptide synthetase U722_07645 ENOG4107SQU synthase U722_07650 ENOG4107SQU synthase U722_07655 ENOG4107SQU synthase U722_07660 ENOG4105C0W non-ribosomal peptide synthetase U722_07665 ENOG4105FQP Beta-lactamase U722_07675 ENOG4105CPP Dehydrogenase, E1 component U722_07680 ENOG4105C7S Dehydrogenase U722_07685 ENOG4107QN2 dihydrolipoyl dehydrogenase U722_07700 ENOG4105CXN decarboxylase U722_07710 ENOG4105WBI UPF0223 protein U722_07725 ENOG4105ECY inositol monophosphatase U722_07735 ENOG4105D4Y metalloprotease U722_07770 ENOG4105CI3 gtp-binding protein typa U722_07775 ENOG4105QA2 U722_07790 ENOG4108IAB Phoh family U722_07800 ENOG4105CSV Glutaminase U722_07810 ENOG4105CNI cell division protein FtsW U722_07815 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) U722_07825 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) U722_07835 ENOG4105BZ9 Cytochrome C oxidase, subunit I U722_07840 ENOG4105CCU oxidase (Subunit III) U722_07845 ENOG41064X9 cytochrome C oxidase subunit IV U722_07860 ENOG41080XQ Signal transduction protein with cbs domains U722_07865 ENOG4106UY4 Inherit from COG: Scp-like extracellular U722_07895 ENOG4106H78 methyltransferase U722_07900 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) U722_07905 ENOG4105H20 Sporulation integral membrane protein YlbJ U722_07910 ENOG4105D78 K07001 NTE family protein U722_07915 ENOG41063PX domain protein U722_07920 ENOG4105CDE UPF0348 protein U722_07930 ENOG4105KNH Nucleic acid-binding protein U722_07935 ENOG41067VY 50S ribosomal protein L32 U722_07965 ENOG4108V6E Cell division protein mraZ U722_07970 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) U722_07980 ENOG4105CJN penicillin-binding protein U722_07985 ENOG4105CJN penicillin-binding protein U722_07990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) U722_07995 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) U722_08000 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) U722_08005 ENOG4105CNI cell division protein FtsW U722_08010 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) U722_08015 ENOG4105D4A Cell wall formation (By similarity) U722_08020 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) U722_08025 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) U722_08030 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) U722_08040 ENOG4105FFI sigma-e processing peptidase spoiiga U722_08045 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_08055 ENOG4105DKW ABC transporter U722_08065 ENOG4105WR5 sporulation protein, YlmC YmxH family U722_08070 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase U722_08075 ENOG4105DFA alanine racemase domain protein U722_08080 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) U722_08085 ENOG41067XK integral membrane protein U722_08090 ENOG4105DBK s4 domain protein U722_08105 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) U722_08115 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) U722_08120 ENOG4105C34 Pseudouridine synthase U722_08125 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) U722_08135 ENOG4105CXT aspartate transcarbamylase U722_08145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain U722_08150 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain U722_08155 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) U722_08160 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) U722_08165 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) U722_08170 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) U722_08190 ENOG4107RIQ Sulfate adenylate transferase U722_08200 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) U722_08205 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein U722_08210 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein U722_08215 ENOG4105F23 Fibronectin-binding protein U722_08225 ENOG4105DSJ YicC domain protein U722_08230 ENOG4105KC4 UPF0296 protein U722_08235 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) U722_08245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase U722_08250 ENOG4105C25 Primosomal protein n' U722_08255 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) U722_08260 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) U722_08265 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B U722_08270 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs U722_08275 ENOG4108ZF3 Phosphatase U722_08280 ENOG4105D9P serine threonine protein kinase U722_08285 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) U722_08290 ENOG4105DJV ribulose-phosphate 3-epimerase U722_08295 ENOG4105FJ0 thiamine U722_08305 ENOG4105VB9 50S ribosomal protein l28 U722_08310 ENOG4108ZAA Alkaline-shock protein U722_08315 ENOG4105DP4 dak2 domain fusion protein ylov U722_08325 ENOG4105EJQ L-serine dehydratase U722_08330 ENOG4105CB5 ATP-dependent DNA helicase recG U722_08335 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) U722_08340 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) U722_08345 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase U722_08350 ENOG4105CHR reductase U722_08355 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) U722_08360 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) U722_08365 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) U722_08370 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) U722_08380 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) U722_08390 ENOG4105K5M 30s ribosomal protein S16 U722_08395 ENOG4108BW8 UPF0109 protein U722_08410 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) U722_08415 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) U722_08420 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) U722_08425 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) U722_08435 ENOG4105VM1 flagellar U722_08440 ENOG4105CMV Succinyl-CoA synthetase subunit beta U722_08445 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha U722_08450 ENOG4105C79 DNA protecting protein DprA U722_08455 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) U722_08460 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) U722_08465 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U722_08470 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) U722_08475 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) U722_08485 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) U722_08490 ENOG4108ZC9 flagellar basal-body rod protein flgc U722_08495 ENOG4105VQ0 flagellar hook-basal body complex protein fliE U722_08500 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) U722_08505 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) U722_08520 ENOG4106YF4 Flagellar biosynthesis chaperone U722_08530 ENOG410696Y Flagellar hook-length control protein U722_08535 ENOG410822I Flagellar hook capping protein U722_08540 ENOG4108JQA flagellar U722_08545 ENOG41068WV flagellar FlbD family protein U722_08555 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) U722_08560 ENOG4105DD5 Flagellar motor switch protein U722_08565 ENOG4107YTP response regulator receiver protein U722_08575 ENOG4105CN7 Flagellar biosynthetic protein FliP U722_08580 ENOG4105VS8 Flagellar biosynthetic protein fliq U722_08585 ENOG4105D19 Role in flagellar biosynthesis (By similarity) U722_08590 ENOG4105D00 flagellar biosynthetic protein flhB U722_08595 ENOG4105D7B Flagellar biosynthesis protein flha U722_08600 ENOG4105FZW flagellar biosynthesis regulator FlhF U722_08610 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) U722_08615 ENOG4105CBS Chea signal transduction histidine kinase U722_08620 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis U722_08630 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) U722_08635 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_08645 ENOG4105CE9 30S ribosomal protein S2 U722_08655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) U722_08660 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) U722_08665 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) U722_08670 ENOG4105KNE Phosphatidate cytidylyltransferase U722_08680 ENOG4105DZP Membrane-associated zinc metalloprotease U722_08685 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) U722_08690 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) U722_08695 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) U722_08700 ENOG4105CHV Transcription elongation factor NusA U722_08705 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination U722_08710 ENOG4105VHM ribosomal protein U722_08715 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) U722_08720 ENOG4105W7A Protein of unknown function (DUF503) U722_08725 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) U722_08730 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) U722_08735 ENOG4105DTN riboflavin biosynthesis protein ribF U722_08740 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) U722_08745 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) U722_08755 ENOG4105C1V Peptidase, M16 U722_08765 ENOG4105E35 Dipicolinate synthase subunit A U722_08770 ENOG4108S0H Dipicolinic acid synthetase, b subunit U722_08775 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) U722_08785 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) U722_08795 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit U722_08805 ENOG4105CNU cell division protein FtsK U722_08810 ENOG4105FDP GntR family transcriptional regulator U722_08825 ENOG4105EYF MMPL domain protein U722_08840 ENOG4108RKS Short-chain dehydrogenase reductase Sdr U722_08845 ENOG4105XZV Protein of unknown function (DUF3243) U722_08860 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase U722_08865 ENOG4105CEV competence damage-inducible protein U722_08870 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) U722_08880 ENOG4108A04 Beta-lactamase U722_08890 ENOG4105D48 metallophosphoesterase U722_08895 ENOG4105MCT stage V sporulation protein S U722_08905 ENOG4105CPQ Dehydrogenase U722_08910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) U722_08915 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) U722_08935 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) U722_08960 ENOG4108151 Beta-lactamase domain protein U722_08965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase U722_08970 ENOG4108JA1 polyketide synthase U722_08975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase U722_08980 ENOG41062T2 Acyl carrier protein U722_08985 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase U722_08990 ENOG4108MGH Enoyl-CoA hydratase U722_08995 ENOG4108KQ6 Enoyl-CoA hydratase U722_09000 ENOG4105C0W non-ribosomal peptide synthetase U722_09005 ENOG4107SQU synthase U722_09015 ENOG4105C0W non-ribosomal peptide synthetase U722_09025 ENOG4106A3M Cytochrome p-450 U722_09030 ENOG4105WFK nuclease U722_09035 ENOG4105XPP Protein of unknown function (DUF1275) U722_09045 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin U722_09060 ENOG4105K7W phage-related replication protein U722_09065 ENOG4108X3M OsmC Ohr family protein U722_09090 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) U722_09120 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) U722_09125 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) U722_09135 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase U722_09145 ENOG4106F1P AAA ATPase, central domain protein U722_09150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) U722_09155 ENOG4105CXI aluminum resistance protein U722_09160 ENOG4105KV4 Transcriptional regulator U722_09165 ENOG4105C5F glutamine synthetase U722_09175 ENOG4105CT4 transporter U722_09180 ENOG4105DSG hydrolase family 43 U722_09190 ENOG4105C93 Xylose Isomerase U722_09195 ENOG4105CMG Carbohydrate kinase U722_09200 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) U722_09225 ENOG4105DQ4 alcohol dehydrogenase U722_09280 ENOG4108M1A Chitin-binding protein U722_09320 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) U722_09325 ENOG4105K7W phage-related replication protein U722_09355 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) U722_09365 ENOG4108SVB resolvase U722_09370 ENOG4105VPS UPF0291 protein U722_09375 ENOG4105CV1 Transketolase (EC 2.2.1.1) U722_09385 ENOG4105VXM UPF0154 protein U722_09395 ENOG4107QIV Cytochrome c biogenesis protein U722_09430 ENOG4108I0Z Aconitate hydratase U722_09435 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen U722_09450 ENOG41067CD Small, acid-soluble spore protein Tlp U722_09460 ENOG4105MI2 U722_09465 ENOG4105W8X HesB YadR YfhF-family protein U722_09470 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) U722_09475 ENOG4105K4P CoA-binding domain protein U722_09480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) U722_09510 ENOG4105CPQ Dehydrogenase U722_09515 ENOG4108UHU Aldolase U722_09520 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) U722_09525 ENOG4105DMW Dehydrogenase reductase U722_09535 ENOG4108I5G Major Facilitator superfamily U722_09535 ENOG4108I5G Major Facilitator superfamily U722_09550 ENOG4105FVX U722_09590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family U722_09600 ENOG4107SYN Glycosyl hydrolases family 43 U722_09630 ENOG4105DTD Dehydrogenase U722_09635 ENOG4108IIH CoA-transferase subunit B U722_09640 ENOG4105D6N CoA-transferase, subunit a U722_09645 ENOG4105CY2 Citrate transporter U722_09650 ENOG4106A3M Cytochrome p-450 U722_09655 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) U722_09660 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) U722_09665 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) U722_09670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) U722_09675 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) U722_09685 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase U722_09690 ENOG4107T5V SNARE associated Golgi U722_09695 ENOG4107QX3 carboxylase U722_09700 ENOG4105E39 Enoyl-CoA hydratase U722_09705 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase U722_09710 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit U722_09715 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase U722_09720 ENOG4105CEY Amp-dependent synthetase and ligase U722_09725 ENOG4105C1G acyl-Coa dehydrogenase U722_09730 ENOG4105F32 YngK protein U722_09735 ENOG4106U2H Protein of unknown function (DUF1360) U722_09765 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family U722_09770 ENOG4108N2V aldose 1-epimerase U722_09775 ENOG4107QJQ Mate efflux family protein U722_09795 ENOG4105C0W non-ribosomal peptide synthetase U722_09805 ENOG4105C0W non-ribosomal peptide synthetase U722_09825 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase U722_09845 ENOG41068G1 U722_09855 ENOG4107X35 defense response to bacterium U722_09935 ENOG4105CAR Terminase, large subunit U722_09970 ENOG410682Q Phage transcriptional regulator, ArpU U722_10120 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) U722_10125 ENOG4108RWP Major Facilitator Superfamily protein U722_10130 ENOG4105WAB arsR family transcriptional regulator U722_10140 ENOG4108KSA LysR family transcriptional regulator U722_10145 ENOG4105CB2 alcohol dehydrogenase U722_10160 ENOG4105BZ8 glutamate synthase U722_10165 ENOG4105CBC glutamate synthase U722_10170 ENOG4105C5Q Transcriptional regulator U722_10175 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) U722_10205 ENOG4108UB7 U722_10210 ENOG4105IE8 Alpha-ketoglutarate permease U722_10215 ENOG4107U6E carbohydrate kinase FGGY U722_10220 ENOG4108M3J Dehydrogenase U722_10225 ENOG4108J2R molybdopterin oxidoreductase U722_10250 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr U722_10265 ENOG4108Z7R Chaperone CsaA U722_10270 ENOG4105FTV AraC Family Transcriptional Regulator U722_10280 ENOG4108W8B Beta-lactamase domain protein U722_10290 ENOG4105KTU Transcriptional regulator, arsr family U722_10300 ENOG4108SJC Membrane U722_10325 ENOG41069ER domain protein U722_10335 ENOG4105C9U ATP-dependent DNA helicase RecQ U722_10345 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) U722_10350 ENOG4105SCY DNAK suppressor U722_10395 ENOG4105C26 Dehydrogenase U722_10400 ENOG4105EWU Squalene--hopene cyclase U722_10405 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) U722_10410 ENOG4105C8J )-transporter U722_10415 ENOG4105C09 Bile acid U722_10425 ENOG4105C7S Dehydrogenase U722_10430 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 U722_10435 ENOG4107T89 von Willebrand factor, type A U722_10440 ENOG4105GMT ATPase associated with various cellular activities aaa_5 U722_10450 ENOG4105K4H Nlp p60 protein U722_10460 ENOG41087PP glycosyltransferase MGT family U722_10475 ENOG4107QMU Mate efflux family protein U722_10480 ENOG4106SCS STAS domain U722_10500 ENOG4105FR1 rard protein U722_10515 ENOG41090U3 tautomerase U722_10535 ENOG4105FBA Phospholipase Carboxylesterase U722_10550 ENOG4105E1V na solute symporter U722_10565 ENOG4105CS2 ec 3.2.1.21 U722_10570 ENOG4108S3Y transcriptional regulator U722_10590 ENOG4108VXD carboxy-peptidase U722_10595 ENOG4105D3A purine nucleoside phosphorylase DeoD-type U722_10605 ENOG4106Z5R U722_10610 ENOG410841Q phosphoesterase PA-phosphatase related protein U722_10645 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein U722_10650 ENOG4108TSC N-acetyltransferase U722_10655 ENOG4107S4Y M20 DapE family protein YgeY U722_10670 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) U722_10675 ENOG4105FTQ Dna gyrase U722_10760 ENOG4108J9Q DNA ligase U722_10835 ENOG4106ANW SMI1_KNR4 U722_10840 ENOG4106BHF U722_10865 ENOG4105E0X reductase U722_10870 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) U722_10880 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) U722_10885 ENOG41090WU lipolytic protein G-D-S-L family U722_10890 ENOG4108KF3 Electron transport protein SCO1 SenC U722_10900 ENOG4105C7B Threonine dehydratase U722_10910 ENOG4108UT2 hemolysin iii U722_10920 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) U722_10925 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) U722_10935 ENOG4107YX5 Pfam:DUF548 U722_10940 ENOG4108Y6J UPF0403 protein U722_10945 ENOG4105C01 Dihydroxy-acid dehydratase U722_10960 ENOG4108V06 Glutathione peroxidase U722_10965 ENOG4105CVG Homoserine O-transsuccinylase U722_11005 ENOG41081VK Ribonuclease U722_11030 ENOG410890F Dynamin family U722_11040 ENOG41065KQ synthase U722_11075 ENOG4105C2W permease U722_11080 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) U722_11085 ENOG4105CTD carboxy-peptidase U722_11090 ENOG4105DVT helicase U722_11105 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) U722_11115 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) U722_11120 ENOG4108UKS UPF0398 protein U722_11135 ENOG4107X2U Inherit from COG: Exonuclease-like protein U722_11185 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) U722_11190 ENOG4105BZ4 penicillin-binding protein U722_11200 ENOG4105CSM endonuclease III U722_11210 ENOG4105C5S asparaginyl-tRNA synthetase U722_11215 ENOG4105CHM Aminotransferase U722_11225 ENOG4105YAC U722_11230 ENOG4105DVT helicase U722_11235 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) U722_11245 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) U722_11255 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate U722_11260 ENOG4105CPK Glycosyl transferase (Group 1 U722_11265 ENOG4105FJR Lmbe family U722_11270 ENOG4108Z5K methylglyoxal synthase U722_11275 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) U722_11280 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase U722_11285 ENOG4108JYZ YitT family U722_11290 ENOG4105F0F Oxalate decarboxylase U722_11310 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) U722_11330 ENOG41068YB TPR repeat-containing protein U722_11335 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase U722_11345 ENOG4105CIH Imidazole acetol-phosphate transaminase U722_11355 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) U722_11360 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase U722_11365 ENOG4105DK0 Indole-3-glycerol phosphate synthase U722_11375 ENOG4105CRQ synthase (Component I) U722_11380 ENOG4105KHN chorismate mutase U722_11390 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase U722_11395 ENOG4105BZU Histidine kinase U722_11400 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) U722_11405 ENOG4105EAH synthase U722_11410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) U722_11415 ENOG4105XXQ heptaprenyl diphosphate synthase component I U722_11420 ENOG4105WP2 Tryptophan RNA-binding attenuator protein U722_11425 ENOG4105EUJ GTP cyclohydrolase i U722_11430 ENOG4105K70 DNA-binding protein U722_11435 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) U722_11450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase U722_11455 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) U722_11480 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) U722_11485 ENOG4105CAT Cytidine monophosphate kinase U722_11500 ENOG4105MSI germination protein ypeb U722_11510 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) U722_11515 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase U722_11535 ENOG4107RGJ metallophosphoesterase U722_11550 ENOG4105I7S Abortive infection protein U722_11555 ENOG4105C9U ATP-dependent DNA helicase RecQ U722_11560 ENOG4105T7X U722_11570 ENOG4108SAX Membrane U722_11575 ENOG4108JQ1 Dehydrogenase U722_11590 ENOG4105BZU Histidine kinase U722_11595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U722_11600 ENOG4105CRE cytochrome C U722_11605 ENOG4107TWT Cytochrome c biogenesis protein U722_11615 ENOG4105FE9 pseudouridine synthase U722_11625 ENOG4108JIC nucleoside recognition domain protein U722_11630 ENOG4105DZ1 carboxypeptidase U722_11640 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) U722_11645 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) U722_11665 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) U722_11670 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) U722_11675 ENOG4108R6K riboflavin synthase, subunit alpha U722_11700 ENOG4107ZE5 PPIases accelerate the folding of proteins U722_11710 ENOG4105PTM secreted protein U722_11715 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) U722_11725 ENOG4105G6R Stage v sporulation protein ae U722_11735 ENOG4105CZ3 stage V sporulation protein ad U722_11740 ENOG41090VF Stage v sporulation protein ac U722_11755 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_11760 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) U722_11765 ENOG41082AN stage II sporulation protein U722_11770 ENOG4105DZ1 carboxypeptidase U722_11775 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) U722_11780 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) U722_11785 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) U722_11795 ENOG4105I3K Ferric uptake regulator, Fur family U722_11800 ENOG4105MZ9 stage II sporulation protein m U722_11820 ENOG4105DFD Na H antiporter U722_11825 ENOG4108IJ0 Aspartate ammonia-lyase U722_11830 ENOG4105HDK L-asparaginase U722_11835 ENOG4108IMY Transcriptional regulator U722_11845 ENOG4108YZ4 nudix hydrolase U722_11855 ENOG4105CPC Aldo Keto reductase U722_11875 ENOG4106HZJ U722_11880 ENOG4105RHY Pfam:UPF0157 U722_11885 ENOG4105KAC Antibiotic biosynthesis monooxygenase U722_11890 ENOG4108XET gCN5-related N-acetyltransferase U722_11895 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) U722_11910 ENOG4105C02 permease U722_11920 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase U722_11925 ENOG4105CS9 pantothenic acid kinase U722_11935 ENOG4108IXY short-chain dehydrogenase reductase U722_11940 ENOG41069FQ Metallo-beta-lactamase superfamily U722_11945 ENOG4105II7 pyrroline-5-carboxylate reductase U722_11950 ENOG4108KQ6 Enoyl-CoA hydratase U722_11955 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase U722_11960 ENOG4106A3M Cytochrome p-450 U722_11970 ENOG4105C0W non-ribosomal peptide synthetase U722_11975 ENOG4105C0W non-ribosomal peptide synthetase U722_11980 ENOG4105C0W non-ribosomal peptide synthetase U722_11985 ENOG4107SQU synthase U722_12000 ENOG4105C0W non-ribosomal peptide synthetase U722_12010 ENOG4105CHR reductase U722_12015 ENOG4105CEY Amp-dependent synthetase and ligase U722_12030 ENOG4107QKG PfaD family U722_12035 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) U722_12040 ENOG4108K70 Transcriptional regulator U722_12050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase U722_12060 ENOG410861F 50S ribosomal protein L33 U722_12065 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) U722_12070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase U722_12075 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) U722_12080 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) U722_12090 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) U722_12095 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) U722_12100 ENOG4108HNZ carboxyl transferase U722_12105 ENOG4108ZVT methylmalonyl-coA epimerase U722_12115 ENOG4108VZI ErfK ybiS ycfS ynhG family protein U722_12120 ENOG4108QEG Membrane U722_12125 ENOG4105CDA abc transporter atp-binding protein U722_12130 ENOG4105E5Q amino acid AbC transporter U722_12135 ENOG4108HW3 (ABC) transporter U722_12145 ENOG4108Y6J UPF0403 protein U722_12150 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) U722_12155 ENOG4105C7S Dehydrogenase U722_12160 ENOG4105CPP Dehydrogenase, E1 component U722_12175 ENOG4105CKM Branched-chain carboxylic acid kinase U722_12180 ENOG4107RDP Dehydrogenase U722_12190 ENOG4108JUB Transcriptional regulator U722_12195 ENOG4106CCJ Protein of unknown function (DUF2627) U722_12200 ENOG4105CR4 methylisocitrate lyase U722_12205 ENOG4105DXD 2-methylcitrate dehydratase U722_12215 ENOG4105C1G acyl-Coa dehydrogenase U722_12220 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase U722_12230 ENOG4108QXE glycerophosphoryl diester phosphodiesterase U722_12235 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase U722_12270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase U722_12285 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) U722_12290 ENOG4107QQR Sporulation U722_12295 ENOG4105S1Z Stage IV sporulation protein B U722_12300 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) U722_12305 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) U722_12310 ENOG4105DX0 Hemolysin A U722_12315 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) U722_12320 ENOG4105CTB Polyprenyl synthetase U722_12325 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) U722_12330 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) U722_12335 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) U722_12340 ENOG4105M7K Involved in the transcription termination process (By similarity) U722_12350 ENOG4108ZSR alkaline shock protein U722_12355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase U722_12375 ENOG410644B Stage III sporulation protein af U722_12385 ENOG4105KQ4 Stage iii sporulation protein ad U722_12390 ENOG4108CQH stage III sporulation protein AC U722_12395 ENOG4105KR5 Stage iii sporulation protein U722_12400 ENOG4105CD2 stage iii sporulation protein aa U722_12410 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) U722_12415 ENOG4105DC7 peptidase M24 U722_12425 ENOG4105CBJ Metal-dependent enzyme U722_12445 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) U722_12450 ENOG4105WZW rhodanese family U722_12455 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor U722_12465 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) U722_12470 ENOG4105C0D helicase U722_12485 ENOG4108IMY Transcriptional regulator U722_12495 ENOG4105VFR signal peptidase U722_12555 ENOG4105C37 (CBS) domain U722_12580 ENOG4105C5X domain protein U722_12625 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase U722_12630 ENOG4105WDJ 50S ribosomal protein L33 U722_12640 ENOG41068DG YceG-like family U722_12645 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) U722_12650 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) U722_12655 ENOG4105E2Z phosphate ABC transporter (Permease U722_12660 ENOG4105C8U phosphate abc transporter U722_12665 ENOG4105CVA phosphate U722_12670 ENOG4107RF6 penicillin-binding protein U722_12680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) U722_12685 ENOG4105SXS Protein of unknown function (DUF456) U722_12700 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) U722_12705 ENOG41063Y9 U722_12710 ENOG4108U5J '-nucleotidase U722_12715 ENOG4105N80 Ferric uptake regulator, Fur family U722_12720 ENOG4108JYZ YitT family U722_12725 ENOG41069ZM Protein of unknown function (DUF2624) U722_12730 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) U722_12745 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) U722_12750 ENOG4105EGD dinuclear metal center protein, YbgI family U722_12765 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_12770 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) U722_12775 ENOG4108UPT UPF0178 protein U722_12780 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) U722_12790 ENOG4105C38 Glycyl-tRNA synthetase beta subunit U722_12795 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit U722_12800 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) U722_12810 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) U722_12815 ENOG4105KG3 cytidine deaminase U722_12820 ENOG4107YR5 Diacylglycerol kinase U722_12825 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) U722_12830 ENOG4105CTJ Metal Dependent Phosphohydrolase U722_12835 ENOG4105C9A Phoh family U722_12840 ENOG4105EI1 sporulation protein yqfd U722_12845 ENOG41068P3 sporulation protein YqfC U722_12855 ENOG4105DI5 UPF0365 protein U722_12860 ENOG4105F7J membrane-bound serine protease U722_12865 ENOG4105KTH gatB Yqey U722_12880 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) U722_12885 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) U722_12890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) U722_12895 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) U722_12900 ENOG4105CFG Acts as a chaperone (By similarity) U722_12905 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ U722_12910 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) U722_12915 ENOG4105CSA Coproporphyrinogen iii oxidase U722_12920 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) U722_12930 ENOG4108ZRV stage ii sporulation protein p U722_12935 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) U722_12940 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) U722_12945 ENOG4105TQK DNA polymerase iii, delta' subunit U722_12955 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 U722_12960 ENOG4108UK2 deaminase U722_12965 ENOG4105KQC Competence protein U722_12975 ENOG4108D32 Methyltransferase U722_12985 ENOG4108WF2 Metal Dependent Phosphohydrolase U722_12990 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) U722_12995 ENOG410812S Rna-binding protein U722_13000 ENOG4105E2X shikimate dehydrogenase U722_13005 ENOG4105CQW ribosome biogenesis GTPase YqeH U722_13010 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase U722_13035 ENOG41080BT SNARE associated Golgi U722_13045 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_13070 ENOG41086D8 Transcriptional regulator U722_13080 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) U722_13090 ENOG4108J8C transporter major facilitator family protein U722_13095 ENOG4108U7W acetyltransferase U722_13110 ENOG4105DQF Hydrolase U722_13115 ENOG4108HCJ Hydrolase U722_13125 ENOG4105DG6 mannose-6-phosphate isomerase U722_13130 ENOG4105DM4 PTS System U722_13150 ENOG4108Z66 YbaK ebsC protein U722_13155 ENOG4107RSM transcriptional regulator U722_13160 ENOG4105D94 Major Facilitator Superfamily U722_13165 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) U722_13170 ENOG41082JN Transcriptional regulator U722_13190 ENOG4105TMB Formate nitrite transporter U722_13195 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) U722_13200 ENOG4108JB9 formate dehydrogenase U722_13215 ENOG4105C28 cystathionine U722_13245 ENOG4107XRG penicillin-binding protein U722_13250 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) U722_13260 ENOG4105CFP Peptidase U32 U722_13265 ENOG4105XYU peptidase (U32 family) U722_13270 ENOG4108VQJ O-methyltransferase U722_13275 ENOG4105HHA aminodeoxychorismate lyase U722_13285 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) U722_13290 ENOG4105VBH UPF0297 protein U722_13295 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) U722_13300 ENOG4105C02 permease U722_13305 ENOG4105CDA abc transporter atp-binding protein U722_13310 ENOG4105CT1 (ABC) transporter U722_13315 ENOG4105EAD ABC transporter U722_13320 ENOG4105DRP amino acid AbC transporter U722_13330 ENOG41060CR U722_13340 ENOG4105C7H Helicase, RecD TraA family U722_13350 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) U722_13355 ENOG4105C3J Cysteine desulfurase U722_13365 ENOG4105D1H recombination factor protein RarA U722_13370 ENOG4105CUZ uba thif-type nad fad binding protein U722_13375 ENOG4105C9M aspartyl-trna synthetase U722_13380 ENOG4105CUT histidyl-tRNA synthetase U722_13395 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase U722_13400 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) U722_13405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) U722_13415 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) U722_13420 ENOG41067VP Protein of unknown function (DUF1049) U722_13425 ENOG4105NCW Trka-c domain protein U722_13430 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) U722_13440 ENOG4105CKP Polysaccharide Biosynthesis Protein U722_13445 ENOG4108QG2 Membrane U722_13450 ENOG4105NAP U722_13455 ENOG4105VIE preprotein translocase, subunit YajC U722_13460 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) U722_13465 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) U722_13470 ENOG41061AI Protein of unknown function (DUF2905) U722_13475 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) U722_13480 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) U722_13500 ENOG4106678 morphogenetic protein associated with SpoVID U722_13505 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) U722_13510 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase U722_13515 ENOG4108IYU L-aspartate oxidase U722_13530 ENOG4105CQC Prephenate dehydratase U722_13540 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control U722_13555 ENOG4105K46 50S ribosomal protein l27 U722_13560 ENOG4105X36 (ribosomal) protein U722_13565 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) U722_13580 ENOG4107QMS site-determining protein U722_13585 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) U722_13590 ENOG4105YHC Rod shape-determining protein MreD U722_13595 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) U722_13600 ENOG4105DFF Rod shape-determining protein mreb U722_13605 ENOG4105W5Q DNA repair protein (RadC U722_13610 ENOG4108Z03 MAF-like protein U722_13620 ENOG4106A3R peptidase U722_13625 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase U722_13630 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) U722_13640 ENOG4106AR7 Spore coat protein U722_13645 ENOG41068KH stage VI sporulation protein D U722_13650 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase U722_13655 ENOG4105D52 delta-aminolevulinic acid dehydratase U722_13665 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) U722_13675 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) U722_13685 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) U722_13690 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) U722_13695 ENOG4108IUQ atp-dependent protease U722_13700 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) U722_13705 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation U722_13720 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) U722_13725 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) U722_13730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) U722_13740 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase U722_13745 ENOG4108ZP8 Acetolactate synthase small subunit U722_13750 ENOG4105C7K acetolactate synthase U722_13785 ENOG4105M59 Phosphodiesterase, mj0936 family U722_13790 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) U722_13795 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) U722_13800 ENOG4108XJQ germination protein U722_13805 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) U722_13810 ENOG41067TZ transcriptional regulator, MarR family U722_13820 ENOG4105PFC Transcriptional regulator U722_13830 ENOG4105E33 succinate dehydrogenase U722_13840 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit U722_13850 ENOG4105CFH Aspartokinase U722_13855 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) U722_13860 ENOG4105K63 Thioredoxin U722_13865 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) U722_13870 ENOG4105C10 Electron transfer flavoprotein U722_13875 ENOG4105BZJ Electron transfer flavoprotein U722_13880 ENOG41060WC Enoyl-CoA hydratase U722_13885 ENOG4107Z3H Transcriptional regulator, TetR family U722_13890 ENOG4105CEY Amp-dependent synthetase and ligase U722_13895 ENOG4108YV3 Protein of unknown function (DUF2711) U722_13910 ENOG4105C98 muts2 protein U722_13915 ENOG4105DCG PHP domain protein U722_13930 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) U722_13935 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) U722_13940 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) U722_13945 ENOG4108RWN rrna methyltransferase U722_13950 ENOG41067MF small acid-soluble spore protein U722_13960 ENOG4105CQB FAD linked oxidase domain protein U722_13965 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) U722_13980 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) U722_13985 ENOG4105DRS transport system, permease U722_14000 ENOG4108MDK Dehydrogenase U722_14010 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase U722_14015 ENOG4105EF1 ribulokinase U722_14025 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase U722_14030 ENOG4105CN9 Peptidase m42 family protein U722_14040 ENOG410696E Membrane U722_14045 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) U722_14050 ENOG4105VJV 50s ribosomal protein L35 U722_14055 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) U722_14060 ENOG41067MG lrgb family U722_14070 ENOG4105DY9 regulatoR U722_14075 ENOG4108HRK Histidine kinase U722_14080 ENOG4105U0R haloacid dehalogenase-like hydrolase U722_14085 ENOG4105C22 threonyL-tRNA synthetase U722_14090 ENOG4108TDW sporulation protein YtxC U722_14120 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) U722_14125 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase U722_14130 ENOG4105KVH Transcriptional regulator U722_14135 ENOG4105F27 Major Facilitator U722_14140 ENOG4105CV8 reductase U722_14145 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) U722_14155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) U722_14160 ENOG4105C2M dna polymerase I U722_14170 ENOG4105BZU Histidine kinase U722_14175 ENOG4105DPZ Two component transcriptional regulator (Winged helix family U722_14190 ENOG4108HMX isocitrate dehydrogenase (NADP) U722_14195 ENOG4105BZN citrate synthase U722_14200 ENOG4105G7B Protein of unknown function (DUF2992) U722_14210 ENOG4108REF Sporulation integral membrane protein ytvi U722_14215 ENOG4105FS0 cytoplasmic membrane protein U722_14220 ENOG4105CA9 Pyruvate kinase U722_14225 ENOG4105CTQ phosphohexokinase U722_14230 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) U722_14235 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) U722_14245 ENOG4105C6K Malic enzyme U722_14250 ENOG4105C0B DNA polymerase III (alpha subunit) U722_14255 ENOG4105VV2 U722_14265 ENOG4106EVM U722_14270 ENOG4105SFS phosphoesterase RecJ domain protein U722_14285 ENOG4105E8R UPF0173 metal-dependent hydrolase U722_14300 ENOG4105CH7 arginosuccinase U722_14305 ENOG4105CDH Citrulline--aspartate ligase U722_14310 ENOG4105EPU Molybdenum cofactor synthesis domain protein U722_14315 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) U722_14325 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) U722_14330 ENOG4105KBJ sporulation protein ytfj U722_14340 ENOG4105VK3 rdd domain containing protein U722_14345 ENOG4105D07 Signal peptide peptidase, SppA U722_14350 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) U722_14355 ENOG4105EFZ amidohydrolase U722_14360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) U722_14370 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) U722_14395 ENOG4105U5Y Transcriptional regulator U722_14405 ENOG4105BZU Histidine kinase U722_14415 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) U722_14425 ENOG4105C26 Dehydrogenase U722_14435 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) U722_14445 ENOG4108Z0Z intracellular protease Pfpi family U722_14470 ENOG4108NGU Transcriptional regulator U722_14490 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) U722_14500 ENOG4105F1V Acetoin utilization protein U722_14505 ENOG4105W87 Cbs domain U722_14510 ENOG4105DGU Histone deacetylase U722_14515 ENOG4105ER2 Ompa motb domain protein U722_14520 ENOG4107R0U MotA TolQ exbB proton channel U722_14525 ENOG4105ETE Transcriptional regulator (LacI family U722_14530 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase U722_14550 ENOG4105DFU Cell wall formation (By similarity) U722_14560 ENOG4108VDD TRNA binding domain protein U722_14575 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ U722_14595 ENOG4105C6K Malic enzyme U722_14600 ENOG4105C8F Beta-lactamase domain protein U722_14605 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) U722_14620 ENOG4108V15 phosphotransferase enzyme family U722_14635 ENOG4107F58 2'-5' rna ligase U722_14640 ENOG4105C6T cysteine synthase U722_14645 ENOG4107QSE Dipeptidase U722_14650 ENOG4105C7N Xanthine uracil vitamin C permease U722_14665 ENOG4105YW5 deoR family transcriptional regulator U722_14680 ENOG4105CBX hi0933 family U722_14685 ENOG4105C94 Transporter U722_14705 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component U722_14710 ENOG4105I1K ABC transporter U722_14725 ENOG41085GJ domain protein U722_14730 ENOG4105C8T Leucyl-tRNA synthetase U722_14740 ENOG4105BZU Histidine kinase U722_14745 ENOG410605W Major Facilitator U722_14760 ENOG4105C19 ABC transporter U722_14765 ENOG4105EWM Histidine kinase U722_14775 ENOG4107R34 abc transporter permease protein U722_14780 ENOG4105C19 ABC transporter U722_14800 ENOG4105DVE abc transporter atp-binding protein U722_14805 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family U722_14830 ENOG4105N5T Radical SAM Protein U722_14845 ENOG4107VXM glycerophosphoryl diester phosphodiesterase U722_14855 ENOG4105E8V Alpha Beta Hydrolase Fold protein U722_14860 ENOG4108Z0R Transferase U722_14865 ENOG4105C85 amino acid U722_14870 ENOG4105CAQ asparagine synthetase U722_14875 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP U722_14885 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase U722_14900 ENOG4105D2X ABC transporter substrate-binding protein U722_14910 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component U722_14925 ENOG4108RMU ferritin dps family protein U722_14940 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) U722_14945 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) U722_14950 ENOG4108V2W Carbonate dehydratase U722_14955 ENOG4105NRA 50s ribosomal protein l31 type b U722_14980 ENOG4105DTQ mandelate racemase muconate lactonizing U722_14985 ENOG4105CEY Amp-dependent synthetase and ligase U722_14990 ENOG4108IPT Naphthoate synthase U722_14995 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) U722_15000 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) U722_15005 ENOG4105E4F Isochorismate synthase U722_15155 ENOG4105N67 Proton-coupled thiamine transporter YuaJ U722_15160 ENOG4105DZ6 Band 7 protein U722_15170 ENOG4106DF1 U722_15175 ENOG4108VNY MOSC domain protein U722_15180 ENOG4108JB8 alcohol dehydrogenase U722_15185 ENOG4105C26 Dehydrogenase U722_15190 ENOG4105TRT Transcriptional regulator U722_15205 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj U722_15210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) U722_15230 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) U722_15240 ENOG4105EE0 oxidoreductase U722_15245 ENOG4108Z0Z intracellular protease Pfpi family U722_15250 ENOG4105C8Q Methyl-accepting chemotaxis U722_15255 ENOG4105C8Q Methyl-accepting chemotaxis U722_15260 ENOG4105C8Q Methyl-accepting chemotaxis U722_15265 ENOG4105C8Q Methyl-accepting chemotaxis U722_15280 ENOG4105EA8 2-Nitropropane dioxygenase U722_15285 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme U722_15295 ENOG4105C37 (CBS) domain U722_15310 ENOG4107PBV potassium channel U722_15315 ENOG4107PBV potassium channel U722_15330 ENOG4107QYV phosphohexose isomerase U722_15340 ENOG4105CHJ isochorismatase hydrolase U722_15350 ENOG4107QW4 alcohol dehydrogenase U722_15355 ENOG4105WG9 Conserved Protein U722_15365 ENOG4105CHM Aminotransferase U722_15370 ENOG4108ZB6 transcriptional regulator AsnC family U722_15375 ENOG4108MUZ hydrolase U722_15385 ENOG4105C87 Aminotransferase class I and II U722_15390 ENOG4108HGU Histidine kinase U722_15395 ENOG4105Y38 Kinase-associated protein B U722_15410 ENOG4105BZ4 penicillin-binding protein U722_15415 ENOG4105KIR Thiol-disulfide oxidoreductase dcc U722_15430 ENOG4108MRH transcriptional regulatory protein U722_15435 ENOG4105DIH basic membrane U722_15440 ENOG4108JQ9 ABC transporter U722_15445 ENOG4105UIB (ABC) transporter U722_15460 ENOG4105D65 subunit l U722_15465 ENOG4105HC0 Na H antiporter U722_15470 ENOG4108ZE9 Monovalent cation H antiporter subunit C U722_15475 ENOG4108JPZ Monovalent cation H antiporter subunit D U722_15480 ENOG4105SC1 monovalent cation H antiporter subunit E U722_15490 ENOG4105KJM monovalent cation h antiporter subunit g U722_15495 ENOG4105KA0 thioesterase Superfamily protein U722_15505 ENOG4105BZU Histidine kinase U722_15535 ENOG4105D58 Diguanylate phosphodiesterase U722_15540 ENOG4105DAP Nicotinate phosphoribosyltransferase U722_15565 ENOG4105C02 permease U722_15580 ENOG410904N short-chain dehydrogenase reductase U722_15615 ENOG4108K8K Transcriptional regulator U722_15620 ENOG4105DCF alanine dehydrogenase U722_15630 ENOG4105WQT MbtH domain protein U722_15635 ENOG4105CEY Amp-dependent synthetase and ligase U722_15640 ENOG4105WQI isochorismatase U722_15645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase U722_15650 ENOG4105E4F Isochorismate synthase U722_15655 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase U722_15660 ENOG4105NIV Esterase U722_15680 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) U722_15690 ENOG41069ER domain protein U722_15705 ENOG4105CEP NADH dehydrogenase U722_15725 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) U722_15740 ENOG4105CJ1 ABC, transporter U722_15770 ENOG4108VHC Short-chain dehydrogenase reductase Sdr U722_15775 ENOG4108YX9 iron--sulfur cluster insertion protein erpA U722_15780 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) U722_15790 ENOG4105ZKE UPF0349 protein U722_15805 ENOG41083MR nifu domain-containing protein U722_15810 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein U722_15815 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) U722_15820 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) U722_15825 ENOG4105D6E homoserine dehydrogenase U722_15835 ENOG4108W5N phosphatidylglycerophosphatase a U722_15840 ENOG4105D4U had-superfamily hydrolase, subfamily iia U722_15850 ENOG4105MMD transcriptional regulator U722_15855 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) U722_15860 ENOG4105FAA peptidase M23 U722_15865 ENOG4108YTE sporulation protein YunB U722_15870 ENOG4107R8B 5'-nucleotidase U722_15880 ENOG4105I3N Conserved Protein U722_15890 ENOG4105CD3 dihydroorotase U722_15895 ENOG4105G9B Transcriptional regulator U722_15920 ENOG4105C5R Aminotransferase U722_15930 ENOG4108K8S endonuclease I U722_15935 ENOG4108IJ9 (ABC) transporter U722_15940 ENOG4105FDP GntR family transcriptional regulator U722_15945 ENOG4108KPW sugar kinase U722_15950 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component U722_15955 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component U722_15960 ENOG4105XN3 extracellular solute-binding protein family 1 U722_15965 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine U722_15980 ENOG4105PKS Excinuclease abc c subunit domain protein U722_15985 ENOG4107VFR oxidoreductase U722_15990 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) U722_16000 ENOG41083Q9 chitosanase U722_16005 ENOG4105DIW FeS assembly protein SUFB U722_16010 ENOG4108UNV SUF system FeS assembly protein, NifU family U722_16015 ENOG4105C9B Cysteine desulfurase U722_16020 ENOG4105JRK feS assembly protein SufD U722_16025 ENOG4105C3K feS assembly ATPase SufC U722_16040 ENOG4105D01 (LipO)protein U722_16045 ENOG4108UMI ABC transporter, permease U722_16050 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) U722_16075 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) U722_16080 ENOG41080E8 Transcriptional regulator, Spx MgsR family U722_16085 ENOG4105C1G acyl-Coa dehydrogenase U722_16090 ENOG4105CHU acetyl-coa acetyltransferase U722_16110 ENOG4105C0R drug resistance transporter emrb qaca subfamily U722_16125 ENOG41067TZ transcriptional regulator, MarR family U722_16130 ENOG4105C0R drug resistance transporter emrb qaca subfamily U722_16135 ENOG4105C5Q Transcriptional regulator U722_16155 ENOG4105E0A ABC, transporter U722_16170 ENOG4105E1F short-chain dehydrogenase reductase U722_16175 ENOG4105HUF DNA protection during starvation protein U722_16180 ENOG4105C0H protease U722_16190 ENOG4105F3H Histidine kinase U722_16205 ENOG41067SE Tetr family transcriptional regulator U722_16210 ENOG4105C9Q fumarate hydratase class II U722_16235 ENOG4105WH1 Two component transcriptional regulator luxr family U722_16240 ENOG4105ENE Histidine kinase U722_16255 ENOG41087YS Phage shock protein A U722_16270 ENOG4108WBT adenosyltransferase U722_16275 ENOG4105E0A ABC, transporter U722_16280 ENOG4105EHG Permease protein U722_16285 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) U722_16290 ENOG4105EWI Short-chain dehydrogenase reductase Sdr U722_16295 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein U722_16305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family U722_16315 ENOG4106DF4 Sigma-70, region 4 U722_16325 ENOG4105F0F Oxalate decarboxylase U722_16335 ENOG4105E0A ABC, transporter U722_16340 ENOG4105EHG Permease protein U722_16345 ENOG4105DQ5 transport system permease protein U722_16355 ENOG4105JQZ Methyltransferase U722_16360 ENOG4105D5Q Arginine ornithine antiporter U722_16375 ENOG4107K5X Membrane-bound metal-dependent hydrolase U722_16380 ENOG4107QZ2 Sulfatase U722_16385 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family U722_16390 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein U722_16395 ENOG4105E0C molybdate abc transporter U722_16400 ENOG4105WH1 Two component transcriptional regulator luxr family U722_16405 ENOG4105BZU Histidine kinase U722_16410 ENOG4105CJ1 ABC, transporter U722_16420 ENOG4108KYE ABC-2 type transporter U722_16435 ENOG4105EEQ Na H antiporter U722_16445 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) U722_16450 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) U722_16455 ENOG4105EEM helicase U722_16460 ENOG4105EN6 Membrane U722_16480 ENOG4107ZQN disulfide bond U722_16485 ENOG4105C59 p-type ATPase U722_16490 ENOG4105C59 p-type ATPase U722_16495 ENOG410681U heavy metal transport detoxification protein U722_16500 ENOG4105VPX protein, conserved in bacteria U722_16505 ENOG4105D9R oxidoreductase U722_16510 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) U722_16545 ENOG4105DEN Luciferase family U722_16550 ENOG4105CDA abc transporter atp-binding protein U722_16575 ENOG4108XSB acetyltransferase, (GNAT) family U722_16580 ENOG4108KSA LysR family transcriptional regulator U722_16585 ENOG4105EWI Short-chain dehydrogenase reductase Sdr U722_16590 ENOG41067XF inhibitor U722_16595 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) U722_16600 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) U722_16610 ENOG4105XZU Preprotein translocase, subunit SecG U722_16630 ENOG4105KVH Transcriptional regulator U722_16655 ENOG4105DA5 (ABC) transporter U722_16660 ENOG4105R40 Glycine betaine carnitine choline U722_16665 ENOG4108HQR Glycine betaine U722_16670 ENOG4105E90 ABC transporter U722_16675 ENOG4108IJ8 ABC transporter U722_16680 ENOG4107HG4 Transcriptional regulator U722_16685 ENOG4105R40 Glycine betaine carnitine choline U722_16690 ENOG4108HQR Glycine betaine U722_16695 ENOG4105E90 ABC transporter U722_16700 ENOG4108IJ8 ABC transporter U722_16705 ENOG4107HG4 Transcriptional regulator U722_16710 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein U722_16720 ENOG4105T65 Membrane-associated protein U722_16725 ENOG4108W0I acetyltransferase U722_16740 ENOG4105FJR Lmbe family U722_16755 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U722_16760 ENOG4108IAJ Nad-dependent epimerase dehydratase U722_16765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U722_16770 ENOG4107QQG Dehydrogenase U722_16775 ENOG4105IIU Aminopeptidase U722_16785 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) U722_16790 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) U722_16795 ENOG4105CP7 Triose-phosphate isomerase U722_16800 ENOG4105BZA Phosphoglycerate kinase U722_16810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase U722_16825 ENOG4105CMD Transcriptional regulator, GntR family U722_16830 ENOG4105DEN Luciferase family U722_16840 ENOG4105GZI Transcriptional regulator U722_16845 ENOG4107RT3 EamA-like transporter family U722_16860 ENOG4106KNT transcriptional regulator U722_16865 ENOG4105CMG Carbohydrate kinase U722_16870 ENOG4105C6Z Gluconate U722_16880 ENOG4107QR9 Iron-sulfur cluster binding protein U722_16885 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) U722_16890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family U722_16895 ENOG4105JXH GntR family transcriptional regulator U722_16900 ENOG4105DAA L-lactate U722_16905 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) U722_16915 ENOG4108ZPC Polysaccharide pyruvyl transferase U722_16920 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U722_16925 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family U722_16930 ENOG4105D3Q Sugar transferase U722_16940 ENOG4105K64 Glycosyl transferase, family 2 U722_16950 ENOG4107QRS glycosyltransferase group 2 family protein U722_16955 ENOG41068W6 Capsular polysaccharide biosynthesis protein U722_16960 ENOG4108KMV Glycosyl transferase (Group 1 U722_16965 ENOG4105K64 Glycosyl transferase, family 2 U722_16970 ENOG4108PQP glycosyl transferase group 1 U722_16980 ENOG4108QV3 biosynthesis protein U722_16985 ENOG4105HTX biosynthesis protein U722_16995 ENOG4105EBR Carboxylesterase U722_17005 ENOG4105NAE bifunctional deaminase-reductase domain protein U722_17015 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 U722_17020 ENOG4105PY6 Phenolic acid decarboxylase U722_17025 ENOG4105NI3 Protein of unknown function (DUF3237) U722_17070 ENOG4108HKT sucrose-6-phosphate hydrolase U722_17075 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) U722_17080 ENOG4105ETE Transcriptional regulator (LacI family U722_17085 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) U722_17090 ENOG4108KAM Transcriptional regulator U722_17095 ENOG4105C7F AcnD-accessory protein PrpF U722_17105 ENOG4108URH decarboxylase U722_17110 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain U722_17115 ENOG4105CHH sulfate transporter U722_17120 ENOG4108V2W Carbonate dehydratase U722_17130 ENOG4105C5I Dehydrogenase U722_17135 ENOG4105GGE ribonuclease U722_17140 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase U722_17145 ENOG4105KRI phosphocarrier protein (HPr U722_17150 ENOG4105CIE May be required for sporulation (By similarity) U722_17155 ENOG4105CHW UPF0052 protein U722_17160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) U722_17165 ENOG4108Z4K mutator MutT protein U722_17175 ENOG4105C3M thioredoxin reductase U722_17190 ENOG4105BZU Histidine kinase U722_17195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U722_17200 ENOG4105GIG U722_17205 ENOG4105BZ1 (ABC) transporter U722_17210 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase U722_17215 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) U722_17220 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase U722_17225 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) U722_17230 ENOG4105ECC imidazole-glycerol-phosphate dehydratase U722_17235 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) U722_17240 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) U722_17245 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) U722_17255 ENOG4108S4C acetyltransferase U722_17260 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) U722_17270 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) U722_17275 ENOG4105CE4 GlcNAc 6-P deacetylase U722_17280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) U722_17285 ENOG4105FDP GntR family transcriptional regulator U722_17290 ENOG4105J7D transcriptional regulator U722_17295 ENOG41088CQ domain protein U722_17300 ENOG41086DT Membrane protein of unknown function U722_17305 ENOG41067S9 phage shock protein C, PspC U722_17310 ENOG4108PY7 U722_17325 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) U722_17330 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) U722_17345 ENOG4105MKU Transcriptional regulator U722_17375 ENOG4105CN1 protease U722_17380 ENOG4108M26 parallel beta-helix repeat protein U722_17385 ENOG4105CRP Part of the ABC transporter FtsEX involved in U722_17390 ENOG4105CAK Cell division ATP-binding protein ftsE U722_17405 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) U722_17410 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving U722_17415 ENOG4105MS2 ribosomal subunit Interface protein U722_17430 ENOG4105MQ3 flagellar protein FliS U722_17435 ENOG4107RT6 flagellar hook-associated U722_17440 ENOG4105I03 Flagellin U722_17450 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) U722_17455 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) U722_17465 ENOG4105DTJ flagellar hook-associated protein U722_17470 ENOG4105E1Q flagellar hook-associated protein U722_17485 ENOG4105RU3 U722_17490 ENOG41081UC Inherit from COG: Competence protein U722_17510 ENOG4105WH1 Two component transcriptional regulator luxr family U722_17515 ENOG4105BZU Histidine kinase U722_17520 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein U722_17525 ENOG4108KGH TRANSCRIPTIONal U722_17530 ENOG4105ESV Glycosyl transferase, family 4 U722_17535 ENOG4107EF8 Glycosyl transferase (Group 1 U722_17550 ENOG4105QZI O-Antigen Polymerase U722_17555 ENOG4105C6Y Udp-glucose 6-dehydrogenase U722_17560 ENOG4107RA4 Glycosyl transferase (Group 1 U722_17565 ENOG4105PSV Polysaccharide Biosynthesis Protein U722_17570 ENOG4105D3Q Sugar transferase U722_17575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase U722_17580 ENOG4105JFG SpoIID LytB domain protein U722_17595 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase U722_17600 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase U722_17605 ENOG4105EY8 ABC transporter U722_17615 ENOG4107SJB teichoic acid biosynthesis U722_17625 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase U722_17635 ENOG4107RZX Teichoic acid biosynthesis protein U722_17645 ENOG4105DG6 mannose-6-phosphate isomerase U722_17665 ENOG4108NHD germination protein U722_17670 ENOG4107R8N Glycosyl transferase, family 2 U722_17675 ENOG4105C54 Major Facilitator superfamily U722_17680 ENOG4108KGH TRANSCRIPTIONal U722_17685 ENOG4105J7I hydrolase U722_17690 ENOG4106UBQ U722_17695 ENOG4105K4H Nlp p60 protein U722_17705 ENOG4105PNM synthesis protein U722_17715 ENOG4105N98 Capsule biosynthesis protein capB U722_17720 ENOG4105E1K spore germination protein U722_17735 ENOG4105ETE Transcriptional regulator (LacI family U722_17740 ENOG4108RVA ribokinase U722_17745 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) U722_17750 ENOG4105C2J ABC transporter U722_17755 ENOG4105CNN ABC, transporter U722_17760 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator U722_17770 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein U722_17775 ENOG4107FQX Alpha-acetolactate decarboxylase U722_17785 ENOG4107RSM transcriptional regulator U722_17805 ENOG4106UIA U722_17825 ENOG4107XC4 flavin reductase domain protein, FMN-binding U722_17835 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) U722_17850 ENOG4105CAH Chromate U722_17855 ENOG4105FGV Chromate U722_17865 ENOG4108WS4 fmn reductase U722_17870 ENOG4107V2S Transcriptional regulator U722_17875 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) U722_17940 ENOG4108XI2 Domain of unknown function (DUF1963) U722_17945 ENOG4105C6Y Udp-glucose 6-dehydrogenase U722_17955 ENOG4108RB3 Capsular polysaccharide biosynthesis protein U722_17960 ENOG4107YJ4 chain length determinant protein U722_17965 ENOG4105HTX biosynthesis protein U722_17975 ENOG4105KBK Zinc finger, swim domain protein U722_17980 ENOG4105C0D helicase U722_17985 ENOG410667J hydrolase U722_17990 ENOG4105E98 transcriptional regulator DeoR family U722_17995 ENOG4105Z8H single-stranded DNA-binding protein U722_18010 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) U722_18015 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) U722_18025 ENOG4105CGA flagellar basal-body rod protein FlgG U722_18035 ENOG4105DFF Rod shape-determining protein mreb U722_18040 ENOG4105MT0 Sporulation transcriptional regulator spoiiid U722_18045 ENOG4107MII Sugar-specific transcriptional regulator TrmB U722_18050 ENOG4105CZM Major Facilitator U722_18055 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease U722_18060 ENOG41080V3 Major Facilitator superfamily U722_18065 ENOG4105D3W isochorismatase U722_18070 ENOG4105BZU Histidine kinase U722_18080 ENOG4105CNI cell division protein FtsW U722_18085 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase U722_18095 ENOG4105FRN stage II sporulation protein U722_18100 ENOG4107TCE N-acetyltransferase U722_18120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) U722_18125 ENOG4106BRK U722_18135 ENOG4107T94 Endo-14-beta-xylanase U722_18145 ENOG4108Z40 Transcriptional regulator U722_18150 ENOG4105CQM Urea amidohydrolase subunit alpha U722_18155 ENOG4105KI2 Urea amidohydrolase subunit beta U722_18160 ENOG4108YZ9 Urea amidohydrolase subunit gamma U722_18180 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) U722_18185 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) U722_18195 ENOG4108TF4 von Willebrand factor, type A U722_18220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) U722_18230 ENOG4106778 Protein of unknown function (DUF1146) U722_18240 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) U722_18245 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) U722_18250 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) U722_18255 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) U722_18260 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) U722_18275 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) U722_18285 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) U722_18290 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) U722_18295 ENOG4108UIC UPF0340 protein U722_18300 ENOG4108YZG isomerase U722_18305 ENOG4107WAU Protein tyrosine phosphatase U722_18310 ENOG410815N Probably functions as a manganese efflux pump (By similarity) U722_18315 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) U722_18325 ENOG4108ZXQ stage ii sporulation protein r U722_18340 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) U722_18345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) U722_18350 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase U722_18360 ENOG4107TT2 Auxin Efflux Carrier U722_18365 ENOG4105C6K Malic enzyme U722_18370 ENOG4107104 thymidine kinase U722_18375 ENOG41082DI 50s ribosomal protein l31 U722_18380 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) U722_18385 ENOG4105CBT Fructose-1,6-bisphosphatase U722_18390 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) U722_18400 ENOG4105D2N Aldolase U722_18405 ENOG410812K response regulator receiver protein U722_18415 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) U722_18425 ENOG4105DF6 Fe-S oxidoreductase U722_18435 ENOG4105E5J UV damage endonuclease U722_18445 ENOG4105BZ1 (ABC) transporter U722_18450 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) U722_18465 ENOG4105R3A Nitrate reductase U722_18470 ENOG4108IUE nitrate reductase beta subunit U722_18490 ENOG4107V6Q Cyclic nucleotide-binding domain U722_18500 ENOG4105C75 arginyL-tRNA synthetase U722_18505 ENOG410684U Domain of unknown function (DUF1934) U722_18515 ENOG4107JM4 Tetratricopeptide repeat U722_18520 ENOG4105CYW agmatinase U722_18525 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) U722_18530 ENOG4105BZ4 penicillin-binding protein U722_18540 ENOG4108XFG YwhD family U722_18545 ENOG4108Z4T Peptidase M50 U722_18550 ENOG41069HH 4-oxalocrotonate tautomerase U722_18555 ENOG41067TZ transcriptional regulator, MarR family U722_18565 ENOG4105CUB amino acid U722_18575 ENOG4105DCI Phosphohydrolase U722_18585 ENOG4108VCI transcription factor, rsfa family U722_18590 ENOG4105K7K Transcriptional regulator U722_18605 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) U722_18610 ENOG4105DUM transcriptional regulator, lysR family U722_18615 ENOG4105HMI Membrane U722_18620 ENOG4108IJ2 phosphate acetyltransferase U722_18625 ENOG4107JTW chlorite dismutase U722_18635 ENOG4105CHM Aminotransferase U722_18665 ENOG4105FCW Major Facilitator superfamily U722_18670 ENOG4105C2C drug resistance transporter, Bcr CflA U722_18685 ENOG4105C26 Dehydrogenase U722_18690 ENOG4105D82 Glutamate dehydrogenase U722_18700 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase U722_18705 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase U722_18710 ENOG4105C1B dTDP-glucose 4-6-dehydratase U722_18715 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) U722_18720 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG U722_18725 ENOG4107TY6 Acylneuraminate cytidylyltransferase U722_18735 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD U722_18740 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase U722_18775 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) U722_18780 ENOG4108RJ9 Glycosyl transferase, family 2 U722_18800 ENOG4105DWF phosphomethylpyrimidine kinase U722_18815 ENOG4105C5Y PTS System U722_18830 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin U722_18835 ENOG4105DEN Luciferase family U722_18840 ENOG4108DBC nitroreductase U722_18850 ENOG4105I4A GCN5-related N-acetyltransferase U722_18870 ENOG4105BZ9 Cytochrome C oxidase, subunit I U722_18875 ENOG4105E2S oxidase) subunit II U722_18880 ENOG4107BMA Transglycosylase associated protein U722_18890 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) U722_18895 ENOG4105WH5 Teichoic acid glycosylation protein U722_18920 ENOG4107ZXU DSBA oxidoreductase U722_18925 ENOG4105DBE peroxidase U722_18935 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) U722_18940 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase U722_18945 ENOG4105CMU LysR family (Transcriptional regulator U722_18950 ENOG4105VAW lrga family U722_18955 ENOG41067MG lrgb family U722_18970 ENOG4107TXC Transcriptional regulator U722_18975 ENOG4105DR4 Methyltransferase U722_18985 ENOG4105CK1 PTS System U722_18990 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin U722_18995 ENOG4105X1N Glycosyl transferase family 8 U722_19005 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase U722_19015 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) U722_19020 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein U722_19025 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) U722_19030 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD U722_19035 ENOG4105CM2 brancheD-chain amino acid aminotransferase U722_19040 ENOG4105F8D glycoside hydrolase family 4 U722_19045 ENOG4105VCP PTS System U722_19050 ENOG4105CK1 PTS System U722_19055 ENOG4105VZJ PTS System U722_19060 ENOG4105EMD TRANSCRIPTIONal U722_19075 ENOG4105DQ5 transport system permease protein U722_19080 ENOG4105EHG Permease protein U722_19090 ENOG41082YX Transcriptional regulator, arsr family U722_19095 ENOG4107R5R arsenical pump membrane protein U722_19100 ENOG4105VZJ PTS System U722_19105 ENOG4105VCP PTS System U722_19110 ENOG4105CK1 PTS System U722_19115 ENOG4105CS2 ec 3.2.1.21 U722_19120 ENOG4105EVU fructokinase U722_19125 ENOG4105DG6 mannose-6-phosphate isomerase U722_19135 ENOG4105CH6 catalase U722_19140 ENOG4107QHE Choloylglycine hydrolase U722_19145 ENOG4105ETS cytosine purines uracil thiamine allantoin U722_19150 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) U722_19155 ENOG4108JJ8 (ABC) transporter U722_19160 ENOG4108JJ9 ABC, transporter U722_19165 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii U722_19170 ENOG4105C4M (Ubiquinol oxidase) subunit I U722_19175 ENOG4105D2K citrate carrier protein U722_19180 ENOG4107BJW polysaccharide deacetylase U722_19195 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) U722_19205 ENOG4105CMR udp-glucose 4-epimerase U722_19210 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) U722_19240 ENOG4105DHI Methyltransferase U722_19270 ENOG4105CH6 catalase U722_19275 ENOG4105D4T Citrate transporter U722_19290 ENOG4105DEU major facilitator superfamily U722_19295 ENOG4105C1J atp-dependent rna helicase U722_19355 ENOG4108NR7 pectate lyase U722_19365 ENOG4107YZX Universal stress protein U722_19370 ENOG4105CS2 ec 3.2.1.21 U722_19430 ENOG4106Z5D Glycoside Hydrolase Family 43 U722_19440 ENOG4105C84 Histidine ammonia-lyase U722_19445 ENOG4105CGP Urocanate hydratase U722_19450 ENOG4105CI2 imidazolone-5-propionate hydrolase U722_19455 ENOG4107W25 arginase agmatinase formiminoglutamase U722_19465 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) U722_19470 ENOG4105D9N nucleoside U722_19475 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) U722_19480 ENOG4107RHR regulatoR U722_19485 ENOG410667J hydrolase U722_19515 ENOG4108V5C ABC transporter U722_19550 ENOG4105WZ4 isomerase U722_19555 ENOG4105F0H myo-inositol catabolism protein U722_19560 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) U722_19570 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) U722_19580 ENOG4105EDK PfkB domain protein U722_19590 ENOG4105C26 Dehydrogenase U722_19600 ENOG4105CPC Aldo Keto reductase U722_19605 ENOG4107QNK )-transporter U722_19610 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) U722_19620 ENOG41061TZ Short-chain dehydrogenase reductase Sdr U722_19625 ENOG4108S01 response regulator U722_19630 ENOG4108ZGX Histidine kinase U722_19635 ENOG4105ECK Fatty Acid Desaturase U722_19645 ENOG4105ST3 Transcriptional regulator U722_19650 ENOG4105C26 Dehydrogenase U722_19655 ENOG4108ITS PQQ enzyme repeat U722_19665 ENOG4105WAB arsR family transcriptional regulator U722_19670 ENOG4105F27 Major Facilitator U722_19675 ENOG41085PJ rdd domain containing protein U722_19685 ENOG4105D3R alkyl hydroperoxide reductase U722_19690 ENOG4108JU3 Alkyl hydroperoxide reductase U722_19695 ENOG4105C85 amino acid U722_19700 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 U722_19705 ENOG4108XHQ (2Fe-2S)-binding domain protein U722_19725 ENOG4105XRQ Xanthine dehydrogenase accessory factor U722_19745 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) U722_19770 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) U722_19780 ENOG4105CPC Aldo Keto reductase U722_19785 ENOG4105WQG acetyltransferase U722_19800 ENOG41066UZ arginase EC 3.5.3.1 U722_19805 ENOG4108IQI permease U722_19810 ENOG4105C8Y Acetylornithine aminotransferase U722_19815 ENOG4108JUB Transcriptional regulator U722_19825 ENOG4105C5H ABC transporter U722_19840 ENOG4105D06 uba thif-type nad fad binding protein U722_19845 ENOG41062D9 Histidine kinase U722_19860 ENOG4105C0H protease U722_19865 ENOG4105Q2H domain protein U722_19880 ENOG4105BZU Histidine kinase U722_19885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family U722_19915 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis U722_19920 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase U722_19925 ENOG4105CDU Replicative dna helicase U722_19945 ENOG4105EDW glycosyl transferase, family 39 U722_19950 ENOG4107QPH glycogen) synthase U722_19960 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR U722_19965 ENOG4105CPK Glycosyl transferase (Group 1 U722_19985 ENOG4105BZR domain protein U722_19990 ENOG4108XMW Membrane U722_20010 ENOG4105KVH Transcriptional regulator U722_20015 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase U722_20020 ENOG4108UZ3 Transporter U722_20025 ENOG4105EDQ levansucrase EC 2.4.1.10 U722_20030 ENOG4108HKT sucrose-6-phosphate hydrolase U722_20035 ENOG4107XBN GntR Family Transcriptional Regulator U722_20055 ENOG4108TVJ Nitroreductase U722_20060 ENOG4105FS7 Transcriptional regulator U722_20070 ENOG4108U05 Transcriptional regulator U722_20085 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase U722_20090 ENOG4105CMU LysR family (Transcriptional regulator U722_20095 ENOG4105DTD Dehydrogenase U722_20105 ENOG4107Y9U Membrane U722_20120 ENOG410847I Transcriptional regulator, BadM Rrf2 family U722_20130 ENOG4108IMY Transcriptional regulator U722_20140 ENOG4105C7Z Conserved Protein U722_20145 ENOG4107FCW Abortive infection protein U722_20155 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase U722_20165 ENOG4105CGK Exodeoxyribonuclease III U722_20170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) U722_20180 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) U722_20185 ENOG4108UUM single-stranded DNA-binding protein U722_20190 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) U722_20195 ENOG4105C3G gtp-binding protein U722_20200 ENOG4108J2R molybdopterin oxidoreductase U722_20205 ENOG4105VDK protein, conserved in bacteria U722_20220 ENOG4108ZDA Sporulation protein YyaC U722_20225 ENOG4105FA0 parb-like partition protein U722_20230 ENOG4107QJE Chromosome Partitioning Protein U722_20245 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) U722_20250 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) U722_20265 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)