locus-tag class description LL3_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LL3_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LL3_00003 ENOG410848D S4 domain protein YaaA LL3_00004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LL3_00006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LL3_00007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LL3_00009 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LL3_00011 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) LL3_00012 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) LL3_00013 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) LL3_00014 ENOG4105BZW Glycerate kinase LL3_00015 ENOG4105ZMH deoxynucleoside kinase LL3_00017 ENOG4105VRS hydrolase family 18 LL3_00018 ENOG4105GTG Isochorismatase LL3_00019 ENOG4108Z6B deaminase LL3_00021 ENOG4105C6E dna polymerase iii LL3_00022 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LL3_00023 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LL3_00025 ENOG41067KS pro-sigma K processing LL3_00028 ENOG4105CDW Resistance protein LL3_00029 ENOG4105CXN decarboxylase LL3_00030 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LL3_00031 ENOG4105X0R protein from nitrogen regulatory protein P-II LL3_00032 ENOG4105XVJ Protein of unknown function (DUF327) LL3_00033 ENOG4105FA2 dna polymerase iii LL3_00034 ENOG4105MA4 psp1 domain protein LL3_00036 ENOG41060K3 Methyltransferase LL3_00037 ENOG4105VC4 domain protein LL3_00038 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LL3_00039 ENOG4105KRN Transcriptional regulator, abrb family LL3_00040 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) LL3_00041 ENOG4105F8V Hydrolase, tatD family LL3_00042 ENOG41069ER domain protein LL3_00044 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) LL3_00045 ENOG4105XFA sporulation peptidase YabG LL3_00046 ENOG4105W42 Veg protein LL3_00047 ENOG4105XEW small acid-soluble spore protein LL3_00048 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) LL3_00049 ENOG4105DFT pur operon repressor LL3_00050 ENOG4105KME endoribonuclease L-psp LL3_00051 ENOG4105K4W Could be involved in septation (By similarity) LL3_00052 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LL3_00053 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LL3_00054 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) LL3_00057 ENOG4108JA2 transcriptioN-repair coupling factor LL3_00058 ENOG4108M14 stage v sporulation protein t LL3_00060 ENOG4108IY2 MazG family LL3_00061 ENOG41082I2 s4 domain protein LL3_00062 ENOG4105VYY sporulation protein yabp LL3_00065 ENOG41060GV RNA binding s1 domain protein LL3_00069 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LL3_00070 ENOG4108UGV hypoxanthine phosphoribosyltransferase LL3_00071 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) LL3_00072 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) LL3_00073 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) LL3_00074 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase LL3_00075 ENOG4105C6T cysteine synthase LL3_00076 ENOG4105CRQ synthase (Component I) LL3_00077 ENOG4105DDQ anthranilate synthase LL3_00078 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 LL3_00079 ENOG4105EEI dihydropteroate synthase LL3_00080 ENOG4105KRF dihydroneopterin aldolase LL3_00081 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase LL3_00083 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LL3_00084 ENOG4105CRK lysyL-tRNA synthetase LL3_00086 ENOG4108Z0C Uvrb UvrC protein LL3_00087 ENOG41066A3 ATP guanido phosphotransferase LL3_00089 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) LL3_00090 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) LL3_00091 ENOG4105CTP PilT protein domain protein LL3_00092 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) LL3_00093 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) LL3_00094 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LL3_00096 ENOG4105D7W serine acetyltransferase LL3_00098 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) LL3_00099 ENOG4105C2N RNA methyltransferase TrmH family group 3 LL3_00100 ENOG4105M0M Tetracycline resistance protein LL3_00104 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LL3_00105 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LL3_00107 ENOG4108VZM 50s ribosomal protein L10 LL3_00108 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) LL3_00109 ENOG4107Y49 methyltransferase LL3_00110 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LL3_00111 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LL3_00112 ENOG4105XPM ribosomal protein LL3_00113 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LL3_00114 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LL3_00115 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LL3_00116 ENOG4107SKW Inherit from COG: Alpha beta hydrolase LL3_00118 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LL3_00119 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LL3_00120 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LL3_00121 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LL3_00122 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LL3_00123 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LL3_00124 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) LL3_00125 ENOG41082SA 50s ribosomal protein l29 LL3_00126 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal LL3_00128 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits LL3_00130 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) LL3_00131 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) LL3_00132 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) LL3_00133 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) LL3_00134 ENOG4105VPB 50S ribosomal protein L30 LL3_00135 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) LL3_00136 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LL3_00137 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LL3_00138 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LL3_00140 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits LL3_00141 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LL3_00142 ENOG4108JJB ABC transporter LL3_00143 ENOG4108JJB ABC transporter LL3_00144 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) LL3_00145 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) LL3_00146 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) LL3_00148 ENOG4108I0C methyltransferase LL3_00151 ENOG4105D1F ATP-binding protein LL3_00154 ENOG4108NMV polysaccharide deacetylase LL3_00157 ENOG4108JPW Aminotransferase LL3_00159 ENOG4105CPQ Dehydrogenase LL3_00161 ENOG4105CHH sulfate transporter LL3_00163 ENOG4108SA1 esterase LL3_00167 ENOG410874W AraC family transcriptional regulator LL3_00168 ENOG4105EHZ conserved protein UCP016719 LL3_00169 ENOG4105D17 glycoside hydrolase, family 3 domain protein LL3_00173 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate LL3_00175 ENOG4105EWC Purine nucleoside phosphorylase LL3_00176 ENOG4105EMN RNA polymerase sigma factor LL3_00178 ENOG4105C8B TIGR00159 family LL3_00179 ENOG4107U5W ybbr family LL3_00180 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LL3_00188 ENOG4106K80 LL3_00190 ENOG41067MG lrgb family LL3_00192 ENOG41061AU MarR family Transcriptional regulator LL3_00195 ENOG4105BZU Histidine kinase LL3_00196 ENOG4105WH1 Two component transcriptional regulator luxr family LL3_00197 ENOG4105CJ1 ABC, transporter LL3_00199 ENOG41090VJ ABC-2 type transporter LL3_00202 ENOG4106DDH Sporulation-specific SASP protein LL3_00206 ENOG4107QTZ amino acid LL3_00207 ENOG4107VXM glycerophosphoryl diester phosphodiesterase LL3_00208 ENOG4105CXY transporter LL3_00215 ENOG4107SCQ Iron-containing alcohol dehydrogenase LL3_00216 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR LL3_00218 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase LL3_00219 ENOG4107ZTW SNARE associated Golgi LL3_00222 ENOG4105C72 UPF0176 protein LL3_00225 ENOG4105CM2 brancheD-chain amino acid aminotransferase LL3_00226 ENOG4108IQI permease LL3_00227 ENOG4108J5H Homocysteine s-methyltransferase LL3_00229 ENOG4105CSV Glutaminase LL3_00237 ENOG41076HS cation diffusion facilitator family transporter LL3_00238 ENOG4108TVJ Nitroreductase LL3_00240 ENOG4108VGI doxx family LL3_00241 ENOG4105XXY Thioredoxin LL3_00247 ENOG4105DGI Alkaline phosphatase LL3_00248 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) LL3_00249 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) LL3_00250 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) LL3_00251 ENOG4107EPV Aminotransferase class V LL3_00252 ENOG4105C0R drug resistance transporter emrb qaca subfamily LL3_00253 ENOG4105J7D transcriptional regulator LL3_00255 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold LL3_00256 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold LL3_00257 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold LL3_00258 ENOG41060AI SEC-C motif LL3_00259 ENOG4107SET aldo keto reductase LL3_00265 ENOG4105H9W Short-chain dehydrogenase reductase Sdr LL3_00268 ENOG4105U3E Transcriptional regulator LL3_00269 ENOG4105DSE periplasmic solute binding protein LL3_00270 ENOG4105DIK (ABC) transporter LL3_00273 ENOG4105DEN Luciferase family LL3_00274 ENOG4108N0M stress protein LL3_00275 ENOG4106FN3 tellurium resistance protein LL3_00276 ENOG4106FN3 tellurium resistance protein LL3_00277 ENOG4107TS3 membrane protein, TerC LL3_00278 ENOG4108TTB tellurium resistance protein LL3_00280 ENOG41079KZ Major Facilitator Superfamily LL3_00281 ENOG4108IJ7 Glycine betaine LL3_00282 ENOG4107SQ8 Glycine betaine LL3_00288 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) LL3_00295 ENOG4107RA1 nh(3)-dependent nad( ) synthetase LL3_00296 ENOG4108WBH protein TIM barrel LL3_00297 ENOG4105DJB Major Facilitator Superfamily LL3_00298 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) LL3_00299 ENOG4105I82 acetyl xylan esterase LL3_00300 ENOG410756H nucleotidyltransferase LL3_00302 ENOG4105C26 Dehydrogenase LL3_00303 ENOG4105CK7 Sodium proline symporter LL3_00304 ENOG4107YHD transcriptional regulator LL3_00305 ENOG4105CAY ferredoxin--nadp reductase LL3_00306 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LL3_00307 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit LL3_00308 ENOG4108IFG nitrite reductase, (NAD(P)H) LL3_00310 ENOG4105CKI cobalamin synthesis protein LL3_00311 ENOG4105E2A Dehydrogenase LL3_00312 ENOG4105HHM rdd domain containing protein LL3_00314 ENOG4105CS2 ec 3.2.1.21 LL3_00317 ENOG41080HJ 6-phospho 3-hexuloisomerase LL3_00318 ENOG4108VA3 3-hexulose-6-phosphate synthase LL3_00319 ENOG4105KVH Transcriptional regulator LL3_00321 ENOG4105CEY Amp-dependent synthetase and ligase LL3_00329 ENOG4105CDA abc transporter atp-binding protein LL3_00330 ENOG4105DRP amino acid AbC transporter LL3_00332 ENOG4106P55 Transcriptional regulator LL3_00333 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase LL3_00334 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LL3_00335 ENOG41069ZX LL3_00336 ENOG41069ZX LL3_00337 ENOG4105DUX Transporter LL3_00341 ENOG4105E1K spore germination protein LL3_00344 ENOG4105CPU Monooxygenase LL3_00345 ENOG4108XSB acetyltransferase, (GNAT) family LL3_00346 ENOG4105EAB amino acid AbC transporter LL3_00349 ENOG4105CH2 amidohydrolase LL3_00350 ENOG4108PGP mmge prpd family protein LL3_00352 ENOG4107WD8 ABC transporter, permease LL3_00354 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_00355 ENOG4105BZU Histidine kinase LL3_00361 ENOG4105CFH Aspartokinase LL3_00363 ENOG4105DHS permease protein LL3_00364 ENOG4105CM4 permease protein LL3_00365 ENOG4108IPW abc transporter atp-binding protein LL3_00368 ENOG4105R8C Transcriptional regulator LL3_00369 ENOG4108DBC nitroreductase LL3_00370 ENOG41067V3 Antibiotic biosynthesis monooxygenase LL3_00371 ENOG4105YVS arsR family transcriptional regulator LL3_00373 ENOG4108JPW Aminotransferase LL3_00374 ENOG4105C26 Dehydrogenase LL3_00376 ENOG4105H9W Short-chain dehydrogenase reductase Sdr LL3_00377 ENOG4105KTB nuclear export factor GLE1 LL3_00378 ENOG4108T5E Copper resistance protein LL3_00379 ENOG4108ZYE Transcriptional regulator LL3_00384 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase LL3_00388 ENOG4105E7W lamb ycsf family protein LL3_00389 ENOG4105C5A transporter LL3_00390 ENOG4105CFM UPF0317 protein LL3_00391 ENOG4105P4J Allophanate hydrolase, subunit 1 LL3_00393 ENOG4107258 Transcriptional regulator LL3_00394 ENOG4105XJB lipolytic protein G-D-S-L family LL3_00396 ENOG41061CK Antibiotic biosynthesis monooxygenase LL3_00397 ENOG4107RVG penicillin-binding protein LL3_00398 ENOG4107QM2 Aldo Keto reductase LL3_00400 ENOG4105ETD TRANSCRIPTIONal LL3_00403 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LL3_00406 ENOG410606W general stress protein LL3_00408 ENOG4105VCH membrane LL3_00410 ENOG4105C9U ATP-dependent DNA helicase RecQ LL3_00414 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) LL3_00415 ENOG4107R8N Glycosyl transferase, family 2 LL3_00417 ENOG4105C0X amino acid LL3_00430 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LL3_00434 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) LL3_00435 ENOG4105RXJ LL3_00436 ENOG4105KPY Small multidrug resistance protein LL3_00437 ENOG4105EU9 LL3_00438 ENOG4105QVS general stress protein LL3_00439 ENOG41082W1 Cupin 2, conserved barrel domain protein LL3_00442 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit LL3_00443 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LL3_00444 ENOG4108MRH transcriptional regulatory protein LL3_00445 ENOG4107QJT sodium dicarboxylate symporter LL3_00446 ENOG4106F5Q Membrane LL3_00447 ENOG4105CJ1 ABC, transporter LL3_00454 ENOG4105SZ6 Thioredoxin LL3_00455 ENOG4105CPF Cell wall formation (By similarity) LL3_00456 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) LL3_00458 ENOG4105C1J atp-dependent rna helicase LL3_00459 ENOG410905X membrane-flanked domain protein LL3_00460 ENOG4105CKV Membrane LL3_00462 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LL3_00463 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein LL3_00465 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LL3_00467 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) LL3_00468 ENOG4107MMM Anti-sigma-factor antagonist LL3_00469 ENOG4105FUA antagonist LL3_00470 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase LL3_00471 ENOG4107SGM protein serine threonine phosphatase LL3_00472 ENOG4105WN5 stage II sporulation protein LL3_00473 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) LL3_00475 ENOG41064BQ Phosphatase LL3_00478 ENOG410906U SprT-like LL3_00481 ENOG4105K56 Transcriptional regulator LL3_00486 ENOG4105VEQ Cold shock protein LL3_00494 ENOG4107U9B transcriptional regulator LL3_00495 ENOG4105DXI Major Facilitator superfamily LL3_00496 ENOG4105IRW patatin-like phospholipase family protein LL3_00498 ENOG4105DNP FAD linked oxidase domain protein LL3_00501 ENOG4105PGM cation diffusion facilitator family transporter LL3_00503 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein LL3_00504 ENOG4108U7W acetyltransferase LL3_00505 ENOG41086D8 Transcriptional regulator LL3_00510 ENOG4105DQ4 alcohol dehydrogenase LL3_00512 ENOG4105VUF Transcriptional regulator LL3_00515 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LL3_00517 ENOG4105EQ0 Major Facilitator superfamily LL3_00518 ENOG4108JGH Tetr family transcriptional regulator LL3_00519 ENOG4105T38 integral membrane protein LL3_00520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LL3_00523 ENOG4105E2A Dehydrogenase LL3_00524 ENOG4105PGS Spore coat protein LL3_00526 ENOG4105EYF MMPL domain protein LL3_00530 ENOG4108JYZ YitT family LL3_00532 ENOG4105C2C drug resistance transporter, Bcr CflA LL3_00533 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LL3_00537 ENOG41090E6 transcriptional regulator MERR family LL3_00540 ENOG4105EBM Alpha Beta Hydrolase Fold protein LL3_00541 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) LL3_00542 ENOG4105DRR Transcriptional regulator, GntR family LL3_00548 ENOG4105FQP Beta-lactamase LL3_00551 ENOG41090UD (LipO)protein LL3_00552 ENOG4108SUT Major Facilitator Superfamily LL3_00553 ENOG4108TZY GntR Family Transcriptional Regulator LL3_00554 ENOG4105JXH GntR family transcriptional regulator LL3_00555 ENOG4105DJ2 Major Facilitator Superfamily LL3_00559 ENOG4107QTZ amino acid LL3_00563 ENOG4107QNK )-transporter LL3_00564 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) LL3_00565 ENOG4105K8N protein family UPF0079, ATPase LL3_00566 ENOG41072GX Peptidase M22 Glycoprotease LL3_00567 ENOG410801F ribosomal-protein-alanine acetyltransferase LL3_00568 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LL3_00569 ENOG4105C5H ABC transporter LL3_00570 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LL3_00571 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) LL3_00572 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) LL3_00573 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) LL3_00575 ENOG4108TYN CAAX amino terminal protease family protein LL3_00576 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) LL3_00577 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) LL3_00590 ENOG4108NF7 phage-type endonuclease LL3_00591 ENOG4108PNI recT protein LL3_00617 ENOG4105IG6 Phage terminase, large subunit LL3_00645 ENOG4105ESF Peptidoglycan binding domain protein LL3_00647 ENOG4105PGZ NB-ARC domain LL3_00649 ENOG4105CPQ Dehydrogenase LL3_00650 ENOG4105CT4 transporter LL3_00653 ENOG41087YS Phage shock protein A LL3_00654 ENOG4105DQX Zinc finger domain LL3_00655 ENOG4108WV1 Pfam:DUF477 LL3_00657 ENOG4105EXC Acyl-transferase LL3_00659 ENOG4108P49 AntiSigma factor LL3_00660 ENOG4105JVQ RNA Polymerase LL3_00666 ENOG4107STQ Multicopper oxidase LL3_00667 ENOG4105C85 amino acid LL3_00670 ENOG4105C7R Atpase associated with various cellular activities aaa_3 LL3_00674 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LL3_00677 ENOG4105C7N Xanthine uracil vitamin C permease LL3_00684 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) LL3_00685 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LL3_00686 ENOG4105C83 adenylosuccinate lyase LL3_00687 ENOG4105C8V SAICAR synthetase LL3_00688 ENOG4105VR9 phosphoribosylformylglycinamidine synthase LL3_00689 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I LL3_00690 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii LL3_00692 ENOG4105CXB phosphoribosylaminoimidazole synthetase LL3_00693 ENOG4108V3E phosphoribosylglycinamide formyltransferase LL3_00694 ENOG4105DC1 bifunctional purine biosynthesis protein purh LL3_00695 ENOG4105C12 Phosphoribosylglycinamide synthetase LL3_00697 ENOG4105DVH amino acid LL3_00700 ENOG4108R5T secreted protein LL3_00701 ENOG4105KGF protein, YerC YecD LL3_00702 ENOG4105CBC glutamate synthase LL3_00705 ENOG4105C4R Atp-dependent dna helicase LL3_00706 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LL3_00708 ENOG4105CRN Aminoglycoside phosphotransferase LL3_00709 ENOG4105KT7 mgtC SapB transporter LL3_00710 ENOG4105CK7 Sodium proline symporter LL3_00711 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LL3_00712 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) LL3_00713 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) LL3_00714 ENOG4108IG5 Transcriptional regulator LL3_00716 ENOG4105CBD Diacylglycerol kinase LL3_00717 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LL3_00719 ENOG4105CJ1 ABC, transporter LL3_00725 ENOG4106BHF LL3_00726 ENOG4105CDY transcriptional regulatory protein LL3_00728 ENOG41075D4 Aminoglycoside 6-adenylyltransferase LL3_00731 ENOG4105WEF catalase LL3_00732 ENOG4105M18 -acetyltransferase LL3_00734 ENOG4105H67 Protein of unknown function (DUF421) LL3_00735 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) LL3_00736 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily LL3_00741 ENOG4106I4J membrane LL3_00742 ENOG41082F9 transcriptional regulator LL3_00743 ENOG41061H0 Monooxygenase LL3_00745 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) LL3_00747 ENOG4105E0M Sulfatase LL3_00749 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase LL3_00751 ENOG41090R9 glycosyltransferase LL3_00752 ENOG4107R51 Glycosyl transferase, family 2 LL3_00753 ENOG41090R9 glycosyltransferase LL3_00754 ENOG4105EU0 Major facilitator Superfamily LL3_00755 ENOG4105CUB amino acid LL3_00756 ENOG4105C26 Dehydrogenase LL3_00757 ENOG4105FKZ Methyl-accepting chemotaxis LL3_00758 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LL3_00759 ENOG4107TVC Glycosyl transferase, family 2 LL3_00760 ENOG4105C5H ABC transporter LL3_00762 ENOG4107SWG transcriptional regulator MERR family LL3_00763 ENOG4105DXB Major Facilitator superfamily LL3_00764 ENOG4105C5H ABC transporter LL3_00765 ENOG4105FDU atp-dependent rna helicase LL3_00766 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein LL3_00769 ENOG4108J20 pectate lyase LL3_00770 ENOG4107QPK )-transporter LL3_00777 ENOG4108NEV two component transcriptional regulator, LytTR family LL3_00779 ENOG4108Z6X (sortase) family LL3_00782 ENOG4108MRH transcriptional regulatory protein LL3_00787 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) LL3_00788 ENOG4108RPX mosc domain containing protein LL3_00792 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) LL3_00800 ENOG4105C5Y PTS System LL3_00801 ENOG4105CG3 alpha amylase, catalytic region LL3_00802 ENOG4107414 GntR family transcriptional regulator LL3_00803 ENOG4108RCM Nitroreductase LL3_00806 ENOG4105CGH 5'-nucleotidase LL3_00807 ENOG4107RKG DJ-1/PfpI family LL3_00808 ENOG4105ETE Transcriptional regulator (LacI family LL3_00809 ENOG4105E2X shikimate dehydrogenase LL3_00810 ENOG4105FF2 Type I DHQase LL3_00813 ENOG4105KJF protein tyrosine phosphatase LL3_00815 ENOG4107U9T Pfam:Ribonuclease_BN LL3_00816 ENOG4108ISG Major Facilitator LL3_00817 ENOG4105UPD Calcium Proton LL3_00819 ENOG4105D8X mechanosensitive ion channel LL3_00823 ENOG4106KE4 Dehydrogenase LL3_00825 ENOG4105D7N magnesium and cobalt transport protein CorA LL3_00827 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LL3_00829 ENOG4105BZ1 (ABC) transporter LL3_00830 ENOG4105CJA serine threonine protein kinase LL3_00837 ENOG4107RUY (E1 component), alpha subunit LL3_00839 ENOG4107QKR Dehydrogenase LL3_00841 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family LL3_00843 ENOG4105F8D glycoside hydrolase family 4 LL3_00844 ENOG4108Q3X Transcriptional regulator LL3_00845 ENOG4105CI1 PTS System LL3_00847 ENOG4105BZ1 (ABC) transporter LL3_00848 ENOG4105BZ1 (ABC) transporter LL3_00850 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase LL3_00852 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LL3_00853 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LL3_00854 ENOG4105U3E Transcriptional regulator LL3_00855 ENOG4105DYS nad(p)h dehydrogenase (quinone) LL3_00856 ENOG4105H93 Acyltransferase family LL3_00859 ENOG4108YYS metal-dependent hydrolase (By similarity) LL3_00860 ENOG4105C0R drug resistance transporter emrb qaca subfamily LL3_00861 ENOG410834F Transcriptional regulator LL3_00863 ENOG4105JAB phenazine biosynthesis protein, phzf family LL3_00864 ENOG4107Y03 Nitroreductase LL3_00867 ENOG4105ECP epimerase LL3_00868 ENOG410902V Modulates RecA activity (By similarity) LL3_00873 ENOG4108TCS Glutamyl endopeptidase LL3_00878 ENOG4106AKJ LL3_00879 ENOG4105D74 hydrolase LL3_00881 ENOG4105CKK Glycosyl transferase, family 2 LL3_00882 ENOG4105EJV Membrane LL3_00883 ENOG41067AE Membrane-bound metal-dependent hydrolase LL3_00886 ENOG4105VTR Integrase LL3_00894 ENOG4108ZUE Phage regulatory protein rha LL3_00899 ENOG4105CDU Replicative dna helicase LL3_00903 ENOG4105CNU cell division protein FtsK LL3_00910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LL3_00933 ENOG4105CEN a g-specific adenine glycosylase LL3_00934 ENOG4106BXE LL3_00935 ENOG4105CAN Short-chain dehydrogenase reductase Sdr LL3_00940 ENOG4105BZ1 (ABC) transporter LL3_00941 ENOG4107NBY Membrane LL3_00942 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase LL3_00943 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LL3_00944 ENOG4105G5W regulator Fur family LL3_00945 ENOG4105TUA UPF0295 protein LL3_00948 ENOG4107S6Z Na H antiporter LL3_00949 ENOG4105EC3 peptidase S51, dipeptidase E LL3_00950 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) LL3_00952 ENOG4105DNP FAD linked oxidase domain protein LL3_00954 ENOG4105DEF Extracellular solute-binding protein, family 5 LL3_00956 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LL3_00957 ENOG4105C3U ABC transporter LL3_00962 ENOG4105E2Y ABC, transporter LL3_00963 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein LL3_00964 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component LL3_00967 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LL3_00968 ENOG4107D63 LL3_00969 ENOG4105VZ8 Transcriptional regulator LL3_00971 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) LL3_00973 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) LL3_00978 ENOG4105CYN Serine protein kinase LL3_00981 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes LL3_00982 ENOG4105CW7 secretion protein, HlyD family LL3_00983 ENOG4105C0R drug resistance transporter emrb qaca subfamily LL3_00984 ENOG4105CS1 NAD(P)H quinone oxidoreductase LL3_00987 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family LL3_00988 ENOG4105CZV ABC transporter LL3_00989 ENOG4105CJ1 ABC, transporter LL3_00990 ENOG4108TU7 Inherit from COG: (ABC) transporter LL3_00991 ENOG4105VEQ Cold shock protein LL3_00993 ENOG4105BZU Histidine kinase LL3_00995 ENOG4105CE7 Amidase, hydantoinase carbamoylase family LL3_01002 ENOG4108YBP pseudouridine synthase LL3_01004 ENOG41080XP Cbs domain LL3_01005 ENOG4107YBY Hydrolase LL3_01006 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase LL3_01007 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) LL3_01008 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator LL3_01010 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) LL3_01011 ENOG4105C6V Glycerol-3-phosphate dehydrogenase LL3_01013 ENOG4105BZU Histidine kinase LL3_01014 ENOG4105WH1 Two component transcriptional regulator luxr family LL3_01021 ENOG4105ED1 spovr family LL3_01022 ENOG4105G6Z alkaline phosphatase LL3_01026 ENOG4105BZN citrate synthase LL3_01027 ENOG4105CYX Short-chain dehydrogenase reductase Sdr LL3_01028 ENOG4105CUB amino acid LL3_01029 ENOG4105C8J )-transporter LL3_01031 ENOG4105J37 LL3_01032 ENOG4108AEY RNA polymerase sigma factor LL3_01033 ENOG4105F6E Acyl-transferase LL3_01034 ENOG4105C37 (CBS) domain LL3_01036 ENOG4105CHM Aminotransferase LL3_01037 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase LL3_01039 ENOG4105C37 (CBS) domain LL3_01041 ENOG4105WMR Protein CrcB homolog LL3_01042 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LL3_01044 ENOG4105D64 Mechanosensitive ion channel LL3_01045 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LL3_01046 ENOG4107VMI polysaccharide deacetylase LL3_01047 ENOG4105F0I Aminotransferase LL3_01048 ENOG4105W1N transcriptional regulator LL3_01050 ENOG4105IIP Membrane LL3_01054 ENOG4105BZ1 (ABC) transporter LL3_01055 ENOG4105BZ1 (ABC) transporter LL3_01061 ENOG410839P LL3_01064 ENOG4106MP8 UPF0754 membrane protein LL3_01065 ENOG4105WZB UPF0342 protein LL3_01068 ENOG4105D4P Coproporphyrinogen iii oxidase LL3_01070 ENOG4107S91 Sodium hydrogen exchanger LL3_01071 ENOG4105NCW Trka-c domain protein LL3_01073 ENOG4105CGU Enoyl-CoA hydratase LL3_01075 ENOG4108IUX (ABC) transporter LL3_01076 ENOG4105RHA ABC transporter, permease LL3_01077 ENOG4107VRP DNA repair exonuclease LL3_01078 ENOG4106D4I domain protein LL3_01079 ENOG4105EQI Metal Dependent Phosphohydrolase LL3_01081 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) LL3_01091 ENOG4105NBU tryptophan transport protein LL3_01092 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) LL3_01093 ENOG4105K59 histidine triad (HIT) protein LL3_01099 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation LL3_01100 ENOG4105BZ4 penicillin-binding protein LL3_01101 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) LL3_01102 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) LL3_01103 ENOG4105C1Q protoporphyrinogen oxidase LL3_01105 ENOG4105ECB domain protein LL3_01109 ENOG4105DER m42 family LL3_01112 ENOG4108RQ5 Beta-lactamase domain-containing protein LL3_01113 ENOG4105DF9 Lipoate-protein, ligase LL3_01115 ENOG4105CEY Amp-dependent synthetase and ligase LL3_01117 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 LL3_01119 ENOG4108HUF Transporter LL3_01120 ENOG4107TB6 phosphoglycerate mutase LL3_01122 ENOG4107F3J Amp-dependent synthetase and ligase LL3_01123 ENOG4107ZYJ bioY protein LL3_01124 ENOG4106YBV Methyl-accepting chemotaxis LL3_01128 ENOG4105XVF Competence transcription factor LL3_01129 ENOG4108ZMX Domain of unknown function (DU1801) LL3_01132 ENOG4105X3H Excalibur domain protein LL3_01133 ENOG4105K8R UPF0145 protein LL3_01134 ENOG4105E1V na solute symporter LL3_01135 ENOG4106CAD Protein of unknown function (DUF3311) LL3_01136 ENOG41060YP LL3_01140 ENOG4107SCK Monooxygenase LL3_01141 ENOG4108INS Transcriptional regulator LL3_01142 ENOG4108KK1 membrane protein AbrB duplication LL3_01144 ENOG4108IG5 Transcriptional regulator LL3_01147 ENOG4108QY0 Membrane LL3_01148 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination LL3_01149 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation LL3_01151 ENOG4105EYH Exonuclease LL3_01162 ENOG4105ERH Fumarylacetoacetate hydrolase LL3_01165 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin LL3_01167 ENOG4105CAQ asparagine synthetase LL3_01169 ENOG4105UQX Mate efflux family protein LL3_01170 ENOG4106HBX Transcriptional Regulator AraC Family LL3_01171 ENOG4105ETE Transcriptional regulator (LacI family LL3_01173 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) LL3_01174 ENOG4105SF0 DinB family LL3_01175 ENOG4108ZUB Lysine exporter protein (Lyse ygga) LL3_01176 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LL3_01177 ENOG4105MYW Pentapeptide repeat protein LL3_01178 ENOG4105MA6 gCN5-related N-acetyltransferase LL3_01181 ENOG4108VPT UPF0234 protein LL3_01182 ENOG4105QNR S1 RNA binding domain protein LL3_01183 ENOG4105DIH basic membrane LL3_01184 ENOG4105C8Q Methyl-accepting chemotaxis LL3_01185 ENOG4107E6A Cytochrome p-450 LL3_01187 ENOG4105EPR degv family LL3_01188 ENOG4107AYK membrAne LL3_01190 ENOG41073B9 LL3_01192 ENOG4108KP7 hydrolase LL3_01193 ENOG4108MXZ Esterase LL3_01194 ENOG4105VG1 fes assembly suf system protein LL3_01195 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) LL3_01196 ENOG4105IQ5 FAD linked oxidase domain protein LL3_01198 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase LL3_01200 ENOG4105CAS nag kinase LL3_01201 ENOG4105C8Y Acetylornithine aminotransferase LL3_01202 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LL3_01204 ENOG4105DBV ornithine carbamoyltransferase LL3_01209 ENOG4107RMD Basic membrane lipoprotein LL3_01212 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LL3_01213 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LL3_01215 ENOG4105C3U ABC transporter LL3_01216 ENOG4108JQ7 (ABC) transporter LL3_01219 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LL3_01221 ENOG4105C31 Tryptophanyl-tRNA synthetase LL3_01222 ENOG4108J59 Extracellular solute-binding protein, family 5 LL3_01223 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LL3_01224 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LL3_01226 ENOG4108JQ7 (ABC) transporter LL3_01229 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) LL3_01230 ENOG4108ZCF integral membrane protein LL3_01231 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis LL3_01233 ENOG4105DPN Oligoendopeptidase f LL3_01235 ENOG4105T58 Dithiol-disulfide isomerase LL3_01236 ENOG4108Z18 K06886 hemoglobin LL3_01237 ENOG4105E4C Lytic transglycosylase catalytic LL3_01238 ENOG4105MIX Adenylate cyclase LL3_01241 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LL3_01242 ENOG4105EMS pseudouridine synthase LL3_01243 ENOG4107S1Q Phosphatase LL3_01246 ENOG4105ETU transcriptional activator (TenA LL3_01247 ENOG4108VEU Thiamine monophosphate synthase LL3_01251 ENOG4105D06 uba thif-type nad fad binding protein LL3_01252 ENOG4105DWF phosphomethylpyrimidine kinase LL3_01253 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH LL3_01254 ENOG4107A88 LL3_01266 ENOG4105ENA helicase LL3_01270 ENOG4105CJ1 ABC, transporter LL3_01273 ENOG4108ZMI UPF0477 protein LL3_01275 ENOG4105C28 cystathionine LL3_01276 ENOG4105C28 cystathionine LL3_01279 ENOG4105VTR Integrase LL3_01285 ENOG4105DB4 LL3_01286 ENOG4105DB4 LL3_01299 ENOG4105C0R drug resistance transporter emrb qaca subfamily LL3_01303 ENOG4105CK1 PTS System LL3_01304 ENOG4105VCP PTS System LL3_01305 ENOG4105CS2 ec 3.2.1.21 LL3_01306 ENOG4105E98 transcriptional regulator DeoR family LL3_01310 ENOG4105KT7 mgtC SapB transporter LL3_01314 ENOG4108IEG Formate dehydrogenase Alpha subunit LL3_01316 ENOG4106A3M Cytochrome p-450 LL3_01317 ENOG41087PP glycosyltransferase MGT family LL3_01319 ENOG4105EXQ uroporphyrinogen iii synthase hem4 LL3_01320 ENOG4105C4B ABC transporter, permease LL3_01321 ENOG4108IXI (ABC) transporter LL3_01323 ENOG4105Q95 Cupin 2, conserved barrel domain protein LL3_01327 ENOG4105D2H Uronic isomerase LL3_01328 ENOG4107KJX Transcriptional regulator LL3_01330 ENOG4105CTX dehydratase LL3_01331 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_01332 ENOG4105F3H Histidine kinase LL3_01334 ENOG4107TSN permease LL3_01339 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase LL3_01340 ENOG4105KWG Pfam:DUF1696 LL3_01341 ENOG4105K7W phage-related replication protein LL3_01342 ENOG410635T phage-like element pbsx protein LL3_01353 ENOG4108TFU terminase (Small subunit) LL3_01354 ENOG4105IG6 Phage terminase, large subunit LL3_01355 ENOG4108MDF Phage Portal Protein LL3_01360 ENOG41060SN LL3_01363 ENOG4105PQS phage protein LL3_01364 ENOG4105FR7 XkdM protein, phage-like element PBSX LL3_01365 ENOG4105MTC XkdN-like protein LL3_01367 ENOG4108FKH Transglycosylase SLT domain LL3_01367 ENOG4108FKH Transglycosylase SLT domain LL3_01367 ENOG4108FKH Transglycosylase SLT domain LL3_01368 ENOG4108WZM domain protein LL3_01369 ENOG4105X7F LL3_01371 ENOG4105MFU Protein of unknown function (DUF2634) LL3_01372 ENOG41066EA baseplate J family protein LL3_01373 ENOG410906S phage-like element pbsx protein xkdt LL3_01375 ENOG41068G1 LL3_01381 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase LL3_01385 ENOG4105CJ3 phosphate transporter LL3_01386 ENOG4107GRR phosphate transport regulator LL3_01387 ENOG4107R7I amino acid LL3_01389 ENOG4105EDW glycosyl transferase, family 39 LL3_01390 ENOG4105CKK Glycosyl transferase, family 2 LL3_01392 ENOG4105C0H protease LL3_01394 ENOG4108ME1 Peptidase M55 D-aminopeptidase LL3_01395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LL3_01396 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LL3_01397 ENOG4105C3U ABC transporter LL3_01399 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A LL3_01400 ENOG4105DTQ mandelate racemase muconate lactonizing LL3_01401 ENOG4107SN7 NLP P60 protein LL3_01402 ENOG4108JQ7 (ABC) transporter LL3_01403 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LL3_01404 ENOG4107TUM Amidinotransferase LL3_01406 ENOG4108S4H thioesterase Superfamily protein LL3_01407 ENOG4108428 Inherit from COG: -acetyltransferase LL3_01409 ENOG41080TC multidrug resistance protein LL3_01410 ENOG4105CIY formyltetrahydrofolate deformylase LL3_01411 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) LL3_01414 ENOG4105K56 Transcriptional regulator LL3_01415 ENOG4108ZHJ Organic hydroperoxide resistance protein LL3_01418 ENOG4107TVC Glycosyl transferase, family 2 LL3_01421 ENOG4105D8G Major Facilitator superfamily LL3_01422 ENOG4108Y4K DNA-binding transcriptional activator LL3_01423 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) LL3_01424 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin LL3_01426 ENOG4108W7F transporter, permease LL3_01427 ENOG4108JJB ABC transporter LL3_01428 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein LL3_01430 ENOG4105VRS hydrolase family 18 LL3_01432 ENOG4105CJW magnesium transporter LL3_01433 ENOG4105V75 Transcriptional regulator LL3_01440 ENOG4105DQE DNA ligase LL3_01441 ENOG4105FDF Could be involved in DNA repair (By similarity) LL3_01442 ENOG4105BZU Histidine kinase LL3_01443 ENOG4107T5V SNARE associated Golgi LL3_01444 ENOG4107TS3 membrane protein, TerC LL3_01445 ENOG4108WZW RNA polymerase sigma LL3_01447 ENOG410681C small acid-soluble spore protein LL3_01449 ENOG4105D0M Protease HtpX homolog LL3_01451 ENOG410900G Protein of unknown function (DUF421) LL3_01453 ENOG4108TGC Acyltransferase LL3_01454 ENOG4105BZU Histidine kinase LL3_01455 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LL3_01457 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) LL3_01459 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase LL3_01461 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate LL3_01462 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) LL3_01463 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) LL3_01464 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) LL3_01466 ENOG4105BZU Histidine kinase LL3_01468 ENOG41090MY MarR family Transcriptional regulator LL3_01469 ENOG4105ER2 Ompa motb domain protein LL3_01470 ENOG4105E14 MotA TolQ exbB proton channel LL3_01473 ENOG4108K88 Membrane LL3_01476 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) LL3_01477 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase LL3_01478 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) LL3_01479 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) LL3_01485 ENOG4105F0V Cell wall hydrolase LL3_01488 ENOG4105C59 p-type ATPase LL3_01489 ENOG4105DC7 peptidase M24 LL3_01492 ENOG4105CID antiterminator LL3_01494 ENOG4105KRI phosphocarrier protein (HPr LL3_01495 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) LL3_01497 ENOG4105F6S Spore photoproduct lyase LL3_01498 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer LL3_01499 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase LL3_01500 ENOG4105K4I Scp-like extracellular LL3_01502 ENOG4105BZU Histidine kinase LL3_01503 ENOG4105CHM Aminotransferase LL3_01506 ENOG4107R88 Chemotaxis protein (CheV) LL3_01507 ENOG4105UIN LL3_01509 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein LL3_01511 ENOG4105K6S Short-chain dehydrogenase reductase Sdr LL3_01513 ENOG4105EPM Diguanylate phosphodiesterase LL3_01514 ENOG4107IN1 Protein of unknown function (DUF1797) LL3_01515 ENOG4108XRC Protein of unknown function (DUF458) LL3_01521 ENOG4105NQC Flavodoxin LL3_01525 ENOG4105D8X mechanosensitive ion channel LL3_01527 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LL3_01531 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) LL3_01532 ENOG4105D06 uba thif-type nad fad binding protein LL3_01533 ENOG4105CVM Molybdenum cofactor synthesis domain protein LL3_01534 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein LL3_01535 ENOG4108ZAF Molybdopterin LL3_01536 ENOG41067WU Molybdopterin converting factor (Subunit 1) LL3_01539 ENOG4107X8C Efflux transporter RND family MFP subunit LL3_01540 ENOG4105C19 ABC transporter LL3_01541 ENOG4107RBB ABC transporter, permease LL3_01542 ENOG4105E98 transcriptional regulator DeoR family LL3_01543 ENOG4105DE4 1-phosphofructokinase LL3_01544 ENOG4105DM4 PTS System LL3_01547 ENOG4105C5H ABC transporter LL3_01548 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LL3_01553 ENOG4105BZU Histidine kinase LL3_01555 ENOG4107ZYR domain protein LL3_01556 ENOG4105CPN adenine deaminase LL3_01557 ENOG4105CN5 Metallo-Beta-Lactamase LL3_01558 ENOG4106148 UPF0356 protein LL3_01560 ENOG4108X4Q Hydrolase LL3_01561 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LL3_01565 ENOG4105CPP Dehydrogenase, E1 component LL3_01566 ENOG4105C7S Dehydrogenase LL3_01567 ENOG4107QN2 dihydrolipoyl dehydrogenase LL3_01571 ENOG4105CXN decarboxylase LL3_01573 ENOG4105WBI UPF0223 protein LL3_01576 ENOG4105ECY inositol monophosphatase LL3_01578 ENOG4105D4Y metalloprotease LL3_01583 ENOG4105CI3 gtp-binding protein typa LL3_01584 ENOG4105QA2 LL3_01587 ENOG4108IAB Phoh family LL3_01589 ENOG4105CSV Glutaminase LL3_01621 ENOG41068G1 LL3_01625 ENOG4105ZUG LL3_01627 ENOG4107D0N LL3_01638 ENOG4105CSV Glutaminase LL3_01640 ENOG4105CNI cell division protein FtsW LL3_01641 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) LL3_01643 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LL3_01646 ENOG4105BZ9 Cytochrome C oxidase, subunit I LL3_01647 ENOG4105CCU oxidase (Subunit III) LL3_01648 ENOG41064X9 cytochrome C oxidase subunit IV LL3_01651 ENOG41080XQ Signal transduction protein with cbs domains LL3_01652 ENOG4106UY4 Inherit from COG: Scp-like extracellular LL3_01658 ENOG4106H78 methyltransferase LL3_01659 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LL3_01660 ENOG4105H20 Sporulation integral membrane protein YlbJ LL3_01661 ENOG4105D78 K07001 NTE family protein LL3_01662 ENOG41063PX domain protein LL3_01663 ENOG4105CDE UPF0348 protein LL3_01664 ENOG4105KNH Nucleic acid-binding protein LL3_01665 ENOG41067VY 50S ribosomal protein L32 LL3_01670 ENOG4108V6E Cell division protein mraZ LL3_01671 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) LL3_01673 ENOG4105CJN penicillin-binding protein LL3_01674 ENOG4105CJN penicillin-binding protein LL3_01675 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LL3_01676 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LL3_01677 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) LL3_01678 ENOG4105CNI cell division protein FtsW LL3_01679 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LL3_01680 ENOG4105D4A Cell wall formation (By similarity) LL3_01681 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) LL3_01683 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) LL3_01684 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) LL3_01686 ENOG4105FFI sigma-e processing peptidase spoiiga LL3_01687 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_01690 ENOG4105DKW ABC transporter LL3_01693 ENOG4105WR5 sporulation protein, YlmC YmxH family LL3_01694 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase LL3_01695 ENOG4105DFA alanine racemase domain protein LL3_01696 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) LL3_01698 ENOG4105DBK s4 domain protein LL3_01700 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LL3_01702 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) LL3_01703 ENOG4105C34 Pseudouridine synthase LL3_01704 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) LL3_01707 ENOG4105CXT aspartate transcarbamylase LL3_01709 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LL3_01710 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LL3_01711 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) LL3_01712 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) LL3_01713 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) LL3_01714 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LL3_01718 ENOG4107RIQ Sulfate adenylate transferase LL3_01720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LL3_01721 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein LL3_01722 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein LL3_01724 ENOG4105F23 Fibronectin-binding protein LL3_01726 ENOG4105DSJ YicC domain protein LL3_01727 ENOG4105KC4 UPF0296 protein LL3_01728 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LL3_01730 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LL3_01731 ENOG4105C25 Primosomal protein n' LL3_01732 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LL3_01733 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LL3_01734 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LL3_01735 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs LL3_01736 ENOG4108ZF3 Phosphatase LL3_01737 ENOG4105D9P serine threonine protein kinase LL3_01738 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LL3_01739 ENOG4105DJV ribulose-phosphate 3-epimerase LL3_01740 ENOG4105FJ0 thiamine LL3_01742 ENOG4105VB9 50S ribosomal protein l28 LL3_01743 ENOG4108ZAA Alkaline-shock protein LL3_01744 ENOG4105DP4 dak2 domain fusion protein ylov LL3_01746 ENOG4105EJQ L-serine dehydratase LL3_01747 ENOG4105CB5 ATP-dependent DNA helicase recG LL3_01748 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) LL3_01749 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LL3_01750 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LL3_01751 ENOG4105CHR reductase LL3_01752 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LL3_01753 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) LL3_01754 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) LL3_01755 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LL3_01756 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) LL3_01758 ENOG4105K5M 30s ribosomal protein S16 LL3_01759 ENOG4108BW8 UPF0109 protein LL3_01762 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LL3_01764 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) LL3_01765 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LL3_01767 ENOG4105VM1 flagellar LL3_01768 ENOG4105CMV Succinyl-CoA synthetase subunit beta LL3_01769 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha LL3_01770 ENOG4105C79 DNA protecting protein DprA LL3_01771 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LL3_01772 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) LL3_01773 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LL3_01774 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) LL3_01775 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) LL3_01777 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) LL3_01778 ENOG4108ZC9 flagellar basal-body rod protein flgc LL3_01779 ENOG4105VQ0 flagellar hook-basal body complex protein fliE LL3_01780 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) LL3_01781 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LL3_01784 ENOG4106YF4 Flagellar biosynthesis chaperone LL3_01786 ENOG410696Y Flagellar hook-length control protein LL3_01787 ENOG410822I Flagellar hook capping protein LL3_01788 ENOG4108JQA flagellar LL3_01789 ENOG41068WV flagellar FlbD family protein LL3_01791 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LL3_01792 ENOG4105DD5 Flagellar motor switch protein LL3_01793 ENOG4107YTP response regulator receiver protein LL3_01795 ENOG4105CN7 Flagellar biosynthetic protein FliP LL3_01796 ENOG4105VS8 Flagellar biosynthetic protein fliq LL3_01797 ENOG4105D19 Role in flagellar biosynthesis (By similarity) LL3_01798 ENOG4105D00 flagellar biosynthetic protein flhB LL3_01799 ENOG4105D7B Flagellar biosynthesis protein flha LL3_01800 ENOG4105FZW flagellar biosynthesis regulator FlhF LL3_01802 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) LL3_01803 ENOG4105CBS Chea signal transduction histidine kinase LL3_01804 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis LL3_01806 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) LL3_01807 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_01809 ENOG4105CE9 30S ribosomal protein S2 LL3_01811 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LL3_01812 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LL3_01813 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LL3_01814 ENOG4105KNE Phosphatidate cytidylyltransferase LL3_01816 ENOG4105DZP Membrane-associated zinc metalloprotease LL3_01817 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LL3_01818 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) LL3_01819 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) LL3_01820 ENOG4105CHV Transcription elongation factor NusA LL3_01821 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination LL3_01822 ENOG4105VHM ribosomal protein LL3_01823 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LL3_01824 ENOG4105W7A Protein of unknown function (DUF503) LL3_01825 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LL3_01826 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LL3_01827 ENOG4105DTN riboflavin biosynthesis protein ribF LL3_01828 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) LL3_01830 ENOG4105C1V Peptidase, M16 LL3_01832 ENOG4105E35 Dipicolinate synthase subunit A LL3_01833 ENOG4108S0H Dipicolinic acid synthetase, b subunit LL3_01834 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LL3_01836 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LL3_01838 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit LL3_01840 ENOG4105CNU cell division protein FtsK LL3_01841 ENOG4105FDP GntR family transcriptional regulator LL3_01844 ENOG4105EYF MMPL domain protein LL3_01847 ENOG4108RKS Short-chain dehydrogenase reductase Sdr LL3_01848 ENOG4105XZV Protein of unknown function (DUF3243) LL3_01851 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LL3_01852 ENOG4105CEV competence damage-inducible protein LL3_01853 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LL3_01854 ENOG4108A04 Beta-lactamase LL3_01856 ENOG4105D48 metallophosphoesterase LL3_01857 ENOG4105MCT stage V sporulation protein S LL3_01858 ENOG4105CPQ Dehydrogenase LL3_01859 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LL3_01860 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LL3_01864 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LL3_01865 ENOG4108151 Beta-lactamase domain protein LL3_01866 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LL3_01867 ENOG4108JA1 polyketide synthase LL3_01868 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LL3_01869 ENOG41062T2 Acyl carrier protein LL3_01870 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase LL3_01871 ENOG4108MGH Enoyl-CoA hydratase LL3_01872 ENOG4108KQ6 Enoyl-CoA hydratase LL3_01873 ENOG4105C0W non-ribosomal peptide synthetase LL3_01874 ENOG4107SQU synthase LL3_01876 ENOG4105C0W non-ribosomal peptide synthetase LL3_01878 ENOG4106A3M Cytochrome p-450 LL3_01879 ENOG4105WFK nuclease LL3_01880 ENOG4105XPP Protein of unknown function (DUF1275) LL3_01883 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin LL3_01887 ENOG4105K7W phage-related replication protein LL3_01888 ENOG4108X3M OsmC Ohr family protein LL3_01893 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) LL3_01898 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LL3_01899 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LL3_01900 ENOG4105U6W MutT NUDIX family protein LL3_01903 ENOG4106F1P AAA ATPase, central domain protein LL3_01904 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LL3_01905 ENOG4105CXI aluminum resistance protein LL3_01906 ENOG4105KV4 Transcriptional regulator LL3_01907 ENOG4105C5F glutamine synthetase LL3_01916 ENOG4105CT4 transporter LL3_01917 ENOG4105DSG hydrolase family 43 LL3_01919 ENOG4105C93 Xylose Isomerase LL3_01920 ENOG4105CMG Carbohydrate kinase LL3_01922 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) LL3_01926 ENOG410780I phosphoprotein phosphatase activity LL3_01930 ENOG4105DQ4 alcohol dehydrogenase LL3_01935 ENOG4105EPI acetyltransferase, (GNAT) family LL3_01943 ENOG4108M1A Chitin-binding protein LL3_01949 ENOG4105YB8 TM2 domain containing protein LL3_01950 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) LL3_01952 ENOG4105K7W phage-related replication protein LL3_01957 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LL3_01959 ENOG4108SVB resolvase LL3_01960 ENOG4105VPS UPF0291 protein LL3_01961 ENOG4105CV1 Transketolase (EC 2.2.1.1) LL3_01963 ENOG4105VXM UPF0154 protein LL3_01965 ENOG4107QIV Cytochrome c biogenesis protein LL3_01972 ENOG4108I0Z Aconitate hydratase LL3_01973 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LL3_01976 ENOG41067CD Small, acid-soluble spore protein Tlp LL3_01978 ENOG4105MI2 LL3_01979 ENOG4105W8X HesB YadR YfhF-family protein LL3_01980 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LL3_01981 ENOG4105K4P CoA-binding domain protein LL3_01982 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LL3_01992 ENOG4105FVX LL3_01996 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LL3_01998 ENOG4107SYN Glycosyl hydrolases family 43 LL3_02006 ENOG4105DTD Dehydrogenase LL3_02007 ENOG4108IIH CoA-transferase subunit B LL3_02008 ENOG4105D6N CoA-transferase, subunit a LL3_02009 ENOG4106A3M Cytochrome p-450 LL3_02010 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) LL3_02011 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) LL3_02012 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LL3_02013 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) LL3_02016 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LL3_02017 ENOG4107T5V SNARE associated Golgi LL3_02018 ENOG4107QX3 carboxylase LL3_02019 ENOG4105E39 Enoyl-CoA hydratase LL3_02020 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase LL3_02021 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit LL3_02022 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LL3_02023 ENOG4105CEY Amp-dependent synthetase and ligase LL3_02024 ENOG4105C1G acyl-Coa dehydrogenase LL3_02025 ENOG4105F32 YngK protein LL3_02026 ENOG4106U2H Protein of unknown function (DUF1360) LL3_02028 ENOG4105CEY Amp-dependent synthetase and ligase LL3_02030 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family LL3_02031 ENOG4108N2V aldose 1-epimerase LL3_02032 ENOG4107QJQ Mate efflux family protein LL3_02037 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) LL3_02038 ENOG4108RWP Major Facilitator Superfamily protein LL3_02039 ENOG4105WAB arsR family transcriptional regulator LL3_02043 ENOG4105BZ8 glutamate synthase LL3_02044 ENOG4105CBC glutamate synthase LL3_02045 ENOG4105C5Q Transcriptional regulator LL3_02046 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) LL3_02051 ENOG4108UB7 LL3_02052 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LL3_02054 ENOG4108QY0 Membrane LL3_02056 ENOG4105CZ3 stage V sporulation protein ad LL3_02057 ENOG41090VF Stage v sporulation protein ac LL3_02064 ENOG4105IE8 Alpha-ketoglutarate permease LL3_02065 ENOG4107U6E carbohydrate kinase FGGY LL3_02066 ENOG4108M3J Dehydrogenase LL3_02073 ENOG4108Z7R Chaperone CsaA LL3_02074 ENOG4105FTV AraC Family Transcriptional Regulator LL3_02076 ENOG4108W8B Beta-lactamase domain protein LL3_02079 ENOG4105KTU Transcriptional regulator, arsr family LL3_02081 ENOG4108SJC Membrane LL3_02088 ENOG41069ER domain protein LL3_02090 ENOG4105C9U ATP-dependent DNA helicase RecQ LL3_02092 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LL3_02093 ENOG4105SCY DNAK suppressor LL3_02102 ENOG4105C26 Dehydrogenase LL3_02103 ENOG4105EWU Squalene--hopene cyclase LL3_02104 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LL3_02105 ENOG4105C8J )-transporter LL3_02106 ENOG4105C09 Bile acid LL3_02108 ENOG4105C7S Dehydrogenase LL3_02109 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 LL3_02110 ENOG4107T89 von Willebrand factor, type A LL3_02111 ENOG4105GMT ATPase associated with various cellular activities aaa_5 LL3_02113 ENOG4105K4H Nlp p60 protein LL3_02115 ENOG41087PP glycosyltransferase MGT family LL3_02118 ENOG4107QMU Mate efflux family protein LL3_02119 ENOG4106SCS STAS domain LL3_02123 ENOG4105FR1 rard protein LL3_02126 ENOG41090U3 tautomerase LL3_02130 ENOG4105FBA Phospholipase Carboxylesterase LL3_02133 ENOG4105E1V na solute symporter LL3_02135 ENOG4105CS2 ec 3.2.1.21 LL3_02136 ENOG4108S3Y transcriptional regulator LL3_02140 ENOG4108VXD carboxy-peptidase LL3_02141 ENOG4105D3A purine nucleoside phosphorylase DeoD-type LL3_02143 ENOG4106Z5R LL3_02144 ENOG410841Q phosphoesterase PA-phosphatase related protein LL3_02148 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily LL3_02151 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein LL3_02152 ENOG4108TSC N-acetyltransferase LL3_02153 ENOG4107S4Y M20 DapE family protein YgeY LL3_02156 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) LL3_02158 ENOG4105FTQ Dna gyrase LL3_02167 ENOG4105C5E polysaccharide biosynthesis protein LL3_02170 ENOG4105DMF Dehydrogenase LL3_02175 ENOG4105E0X reductase LL3_02176 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LL3_02178 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) LL3_02179 ENOG41090WU lipolytic protein G-D-S-L family LL3_02180 ENOG4108KF3 Electron transport protein SCO1 SenC LL3_02182 ENOG4105C7B Threonine dehydratase LL3_02184 ENOG4108UT2 hemolysin iii LL3_02186 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LL3_02187 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LL3_02189 ENOG4107YX5 Pfam:DUF548 LL3_02190 ENOG4108Y6J UPF0403 protein LL3_02191 ENOG4105C01 Dihydroxy-acid dehydratase LL3_02194 ENOG4108V06 Glutathione peroxidase LL3_02196 ENOG4105CVG Homoserine O-transsuccinylase LL3_02204 ENOG41081VK Ribonuclease LL3_02209 ENOG410890F Dynamin family LL3_02213 ENOG41065KQ synthase LL3_02218 ENOG4105C2W permease LL3_02220 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) LL3_02232 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LL3_02233 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LL3_02239 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) LL3_02241 ENOG4106ITI Glutaredoxin LL3_02243 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LL3_02247 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LL3_02261 ENOG4105DVF Cytosine-specific methyltransferase LL3_02263 ENOG4106210 phosphatase activity LL3_02268 ENOG4106J9J DNA polymerase LL3_02270 ENOG4106IVX LL3_02271 ENOG4106PTB DnaB-like helicase C terminal domain LL3_02273 ENOG41088HM LL3_02274 ENOG4106YR8 LL3_02278 ENOG4105K7W phage-related replication protein LL3_02284 ENOG4108RAV Conserved protein LL3_02285 ENOG4108J9Q DNA ligase LL3_02315 ENOG4107D0N LL3_02325 ENOG4107NTZ LL3_02329 ENOG4108ZUE Phage regulatory protein rha LL3_02330 ENOG4105C4R Atp-dependent dna helicase LL3_02335 ENOG4108NE4 LL3_02340 ENOG4105K70 DNA-binding protein LL3_02342 ENOG4106QVS LL3_02359 ENOG41068G1 LL3_02376 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase LL3_02381 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LL3_02382 ENOG4105EKQ RNA-directed DNA polymerase LL3_02383 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LL3_02386 ENOG4108YTE sporulation protein YunB LL3_02389 ENOG4106BHF LL3_02390 ENOG4107Y9E nuclease LL3_02392 ENOG4105C2W permease LL3_02393 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) LL3_02394 ENOG4105CTD carboxy-peptidase LL3_02395 ENOG4105DVT helicase LL3_02399 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LL3_02400 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) LL3_02401 ENOG4108UKS UPF0398 protein LL3_02402 ENOG4107X2U Inherit from COG: Exonuclease-like protein LL3_02403 ENOG4108I5C dEAD DEAH box helicase LL3_02412 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) LL3_02413 ENOG4105BZ4 penicillin-binding protein LL3_02415 ENOG4105CSM endonuclease III LL3_02417 ENOG4105C5S asparaginyl-tRNA synthetase LL3_02418 ENOG4105CHM Aminotransferase LL3_02420 ENOG4105YAC LL3_02422 ENOG4105DVT helicase LL3_02424 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) LL3_02426 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) LL3_02428 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate LL3_02429 ENOG4105CPK Glycosyl transferase (Group 1 LL3_02430 ENOG4105FJR Lmbe family LL3_02431 ENOG4108Z5K methylglyoxal synthase LL3_02432 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) LL3_02433 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase LL3_02434 ENOG4108JYZ YitT family LL3_02435 ENOG4105F0F Oxalate decarboxylase LL3_02439 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) LL3_02443 ENOG41068YB TPR repeat-containing protein LL3_02445 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase LL3_02447 ENOG4105CIH Imidazole acetol-phosphate transaminase LL3_02449 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) LL3_02450 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase LL3_02451 ENOG4105DK0 Indole-3-glycerol phosphate synthase LL3_02453 ENOG4105CRQ synthase (Component I) LL3_02454 ENOG4105KHN chorismate mutase LL3_02456 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase LL3_02457 ENOG4105BZU Histidine kinase LL3_02458 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) LL3_02459 ENOG4105EAH synthase LL3_02460 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LL3_02461 ENOG4105XXQ heptaprenyl diphosphate synthase component I LL3_02462 ENOG4105WP2 Tryptophan RNA-binding attenuator protein LL3_02463 ENOG4105EUJ GTP cyclohydrolase i LL3_02464 ENOG4105K70 DNA-binding protein LL3_02465 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) LL3_02468 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase LL3_02469 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) LL3_02472 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LL3_02473 ENOG4105CAT Cytidine monophosphate kinase LL3_02476 ENOG4105MSI germination protein ypeb LL3_02478 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) LL3_02479 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase LL3_02482 ENOG4107RGJ metallophosphoesterase LL3_02485 ENOG4105I7S Abortive infection protein LL3_02486 ENOG4105C9U ATP-dependent DNA helicase RecQ LL3_02487 ENOG4105T7X LL3_02490 ENOG4108SAX Membrane LL3_02492 ENOG4108JQ1 Dehydrogenase LL3_02495 ENOG4105BZU Histidine kinase LL3_02496 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_02497 ENOG4105CRE cytochrome C LL3_02498 ENOG4107TWT Cytochrome c biogenesis protein LL3_02500 ENOG4105FE9 pseudouridine synthase LL3_02502 ENOG4108JIC nucleoside recognition domain protein LL3_02503 ENOG4105DZ1 carboxypeptidase LL3_02505 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) LL3_02506 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) LL3_02509 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LL3_02510 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LL3_02511 ENOG4108R6K riboflavin synthase, subunit alpha LL3_02518 ENOG4107ZE5 PPIases accelerate the folding of proteins LL3_02520 ENOG4105PTM secreted protein LL3_02521 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LL3_02523 ENOG4105G6R Stage v sporulation protein ae LL3_02525 ENOG4105CZ3 stage V sporulation protein ad LL3_02526 ENOG41090VF Stage v sporulation protein ac LL3_02529 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_02530 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) LL3_02531 ENOG41082AN stage II sporulation protein LL3_02532 ENOG4105DZ1 carboxypeptidase LL3_02533 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) LL3_02534 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) LL3_02535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LL3_02537 ENOG4105I3K Ferric uptake regulator, Fur family LL3_02538 ENOG4105MZ9 stage II sporulation protein m LL3_02542 ENOG4105DFD Na H antiporter LL3_02543 ENOG4108IJ0 Aspartate ammonia-lyase LL3_02544 ENOG4105HDK L-asparaginase LL3_02545 ENOG4108IMY Transcriptional regulator LL3_02547 ENOG4108YZ4 nudix hydrolase LL3_02549 ENOG4105CPC Aldo Keto reductase LL3_02553 ENOG4106HZJ LL3_02554 ENOG4105RHY Pfam:UPF0157 LL3_02556 ENOG4108XET gCN5-related N-acetyltransferase LL3_02557 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LL3_02560 ENOG4105C02 permease LL3_02562 ENOG4105CS9 pantothenic acid kinase LL3_02564 ENOG4108IXY short-chain dehydrogenase reductase LL3_02565 ENOG41069FQ Metallo-beta-lactamase superfamily LL3_02566 ENOG4105II7 pyrroline-5-carboxylate reductase LL3_02568 ENOG4108K70 Transcriptional regulator LL3_02570 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LL3_02572 ENOG410861F 50S ribosomal protein L33 LL3_02573 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LL3_02574 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase LL3_02575 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LL3_02576 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LL3_02578 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) LL3_02579 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LL3_02580 ENOG4108HNZ carboxyl transferase LL3_02581 ENOG4108ZVT methylmalonyl-coA epimerase LL3_02582 ENOG4108VZI ErfK ybiS ycfS ynhG family protein LL3_02583 ENOG4108QEG Membrane LL3_02584 ENOG4105CDA abc transporter atp-binding protein LL3_02585 ENOG4105E5Q amino acid AbC transporter LL3_02586 ENOG4108HW3 (ABC) transporter LL3_02587 ENOG4108Y6J UPF0403 protein LL3_02588 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) LL3_02589 ENOG4105C7S Dehydrogenase LL3_02590 ENOG4105CPP Dehydrogenase, E1 component LL3_02593 ENOG4105CKM Branched-chain carboxylic acid kinase LL3_02594 ENOG4107RDP Dehydrogenase LL3_02596 ENOG4108JUB Transcriptional regulator LL3_02597 ENOG4106CCJ Protein of unknown function (DUF2627) LL3_02598 ENOG4105CR4 methylisocitrate lyase LL3_02599 ENOG4105DXD 2-methylcitrate dehydratase LL3_02601 ENOG4105C1G acyl-Coa dehydrogenase LL3_02602 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LL3_02604 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LL3_02605 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LL3_02612 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LL3_02615 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LL3_02617 ENOG4107QQR Sporulation LL3_02618 ENOG4105S1Z Stage IV sporulation protein B LL3_02619 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LL3_02620 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) LL3_02621 ENOG4105DX0 Hemolysin A LL3_02622 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) LL3_02623 ENOG4105CTB Polyprenyl synthetase LL3_02624 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LL3_02625 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LL3_02626 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LL3_02627 ENOG4105M7K Involved in the transcription termination process (By similarity) LL3_02629 ENOG4108ZSR alkaline shock protein LL3_02630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LL3_02634 ENOG410644B Stage III sporulation protein af LL3_02636 ENOG4105KQ4 Stage iii sporulation protein ad LL3_02637 ENOG4108CQH stage III sporulation protein AC LL3_02638 ENOG4105KR5 Stage iii sporulation protein LL3_02639 ENOG4105CD2 stage iii sporulation protein aa LL3_02641 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LL3_02642 ENOG4105DC7 peptidase M24 LL3_02644 ENOG4105CBJ Metal-dependent enzyme LL3_02648 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) LL3_02650 ENOG4105WZW rhodanese family LL3_02651 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor LL3_02653 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) LL3_02654 ENOG4105C0D helicase LL3_02658 ENOG4108IMY Transcriptional regulator LL3_02660 ENOG4105VFR signal peptidase LL3_02673 ENOG4105C37 (CBS) domain LL3_02677 ENOG4105C5X domain protein LL3_02686 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LL3_02689 ENOG41068DG YceG-like family LL3_02691 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LL3_02692 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LL3_02693 ENOG4105E2Z phosphate ABC transporter (Permease LL3_02694 ENOG4105C8U phosphate abc transporter LL3_02695 ENOG4105CVA phosphate LL3_02696 ENOG4107RF6 penicillin-binding protein LL3_02698 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LL3_02699 ENOG4105SXS Protein of unknown function (DUF456) LL3_02702 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) LL3_02703 ENOG41063Y9 LL3_02704 ENOG4108U5J '-nucleotidase LL3_02705 ENOG4105N80 Ferric uptake regulator, Fur family LL3_02706 ENOG4108JYZ YitT family LL3_02707 ENOG41069ZM Protein of unknown function (DUF2624) LL3_02708 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LL3_02711 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) LL3_02712 ENOG4105EGD dinuclear metal center protein, YbgI family LL3_02715 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_02716 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LL3_02717 ENOG4108UPT UPF0178 protein LL3_02718 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LL3_02720 ENOG4105C38 Glycyl-tRNA synthetase beta subunit LL3_02721 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit LL3_02722 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) LL3_02724 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) LL3_02725 ENOG4105KG3 cytidine deaminase LL3_02726 ENOG4107YR5 Diacylglycerol kinase LL3_02727 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) LL3_02728 ENOG4105CTJ Metal Dependent Phosphohydrolase LL3_02729 ENOG4105C9A Phoh family LL3_02730 ENOG4105EI1 sporulation protein yqfd LL3_02731 ENOG41068P3 sporulation protein YqfC LL3_02733 ENOG4105DI5 UPF0365 protein LL3_02734 ENOG4105F7J membrane-bound serine protease LL3_02735 ENOG4105KTH gatB Yqey LL3_02738 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LL3_02739 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LL3_02740 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LL3_02741 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LL3_02742 ENOG4105CFG Acts as a chaperone (By similarity) LL3_02743 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ LL3_02744 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) LL3_02745 ENOG4105CSA Coproporphyrinogen iii oxidase LL3_02746 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) LL3_02748 ENOG4108ZRV stage ii sporulation protein p LL3_02749 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) LL3_02750 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LL3_02751 ENOG4105TQK DNA polymerase iii, delta' subunit LL3_02754 ENOG4108UK2 deaminase LL3_02755 ENOG4105KQC Competence protein LL3_02757 ENOG4108D32 Methyltransferase LL3_02759 ENOG4108WF2 Metal Dependent Phosphohydrolase LL3_02760 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) LL3_02761 ENOG410812S Rna-binding protein LL3_02762 ENOG4105E2X shikimate dehydrogenase LL3_02763 ENOG4105CQW ribosome biogenesis GTPase YqeH LL3_02764 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase LL3_02769 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase LL3_02770 ENOG41080BT SNARE associated Golgi LL3_02774 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_02777 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_02779 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LL3_02782 ENOG4108J8C transporter major facilitator family protein LL3_02786 ENOG4105DQF Hydrolase LL3_02787 ENOG4108HCJ Hydrolase LL3_02790 ENOG4105DG6 mannose-6-phosphate isomerase LL3_02791 ENOG4105DM4 PTS System LL3_02795 ENOG4108Z66 YbaK ebsC protein LL3_02798 ENOG4107RSM transcriptional regulator LL3_02799 ENOG4105D94 Major Facilitator Superfamily LL3_02800 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) LL3_02801 ENOG41082JN Transcriptional regulator LL3_02806 ENOG4105TMB Formate nitrite transporter LL3_02807 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) LL3_02808 ENOG4108JB9 formate dehydrogenase LL3_02811 ENOG4105C28 cystathionine LL3_02817 ENOG4107XRG penicillin-binding protein LL3_02818 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LL3_02820 ENOG4105CFP Peptidase U32 LL3_02821 ENOG4105XYU peptidase (U32 family) LL3_02822 ENOG4108VQJ O-methyltransferase LL3_02823 ENOG4105HHA aminodeoxychorismate lyase LL3_02825 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LL3_02826 ENOG4105VBH UPF0297 protein LL3_02827 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LL3_02828 ENOG4105C02 permease LL3_02829 ENOG4105CDA abc transporter atp-binding protein LL3_02830 ENOG4105CT1 (ABC) transporter LL3_02831 ENOG4105EAD ABC transporter LL3_02832 ENOG4105DRP amino acid AbC transporter LL3_02834 ENOG41060CR LL3_02836 ENOG4105C7H Helicase, RecD TraA family LL3_02838 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LL3_02839 ENOG4105C3J Cysteine desulfurase LL3_02841 ENOG4105D1H recombination factor protein RarA LL3_02843 ENOG4105CUZ uba thif-type nad fad binding protein LL3_02844 ENOG4105C9M aspartyl-trna synthetase LL3_02845 ENOG4105CUT histidyl-tRNA synthetase LL3_02848 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LL3_02849 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) LL3_02850 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LL3_02852 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LL3_02853 ENOG41067VP Protein of unknown function (DUF1049) LL3_02854 ENOG4105NCW Trka-c domain protein LL3_02855 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LL3_02857 ENOG4105CKP Polysaccharide Biosynthesis Protein LL3_02858 ENOG4108QG2 Membrane LL3_02859 ENOG4105NAP LL3_02860 ENOG4105VIE preprotein translocase, subunit YajC LL3_02861 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) LL3_02862 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) LL3_02863 ENOG41061AI Protein of unknown function (DUF2905) LL3_02864 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LL3_02865 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LL3_02869 ENOG4106678 morphogenetic protein associated with SpoVID LL3_02870 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) LL3_02871 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase LL3_02872 ENOG4108IYU L-aspartate oxidase LL3_02875 ENOG4105CQC Prephenate dehydratase LL3_02877 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control LL3_02879 ENOG4105K46 50S ribosomal protein l27 LL3_02880 ENOG4105X36 (ribosomal) protein LL3_02881 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) LL3_02884 ENOG4107QMS site-determining protein LL3_02885 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) LL3_02886 ENOG4105YHC Rod shape-determining protein MreD LL3_02887 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) LL3_02888 ENOG4105DFF Rod shape-determining protein mreb LL3_02889 ENOG4105W5Q DNA repair protein (RadC LL3_02890 ENOG4108Z03 MAF-like protein LL3_02892 ENOG4106A3R peptidase LL3_02893 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LL3_02894 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) LL3_02896 ENOG4106AR7 Spore coat protein LL3_02897 ENOG41068KH stage VI sporulation protein D LL3_02898 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase LL3_02899 ENOG4105D52 delta-aminolevulinic acid dehydratase LL3_02901 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) LL3_02903 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) LL3_02905 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LL3_02906 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) LL3_02907 ENOG4108IUQ atp-dependent protease LL3_02908 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LL3_02909 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LL3_02912 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LL3_02913 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LL3_02914 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) LL3_02916 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase LL3_02917 ENOG4108ZP8 Acetolactate synthase small subunit LL3_02918 ENOG4105C7K acetolactate synthase LL3_02922 ENOG4105M59 Phosphodiesterase, mj0936 family LL3_02923 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LL3_02924 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) LL3_02925 ENOG4108XJQ germination protein LL3_02926 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) LL3_02927 ENOG41067TZ transcriptional regulator, MarR family LL3_02929 ENOG4105PFC Transcriptional regulator LL3_02931 ENOG4105E33 succinate dehydrogenase LL3_02933 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit LL3_02935 ENOG4105CFH Aspartokinase LL3_02936 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LL3_02937 ENOG4105K63 Thioredoxin LL3_02938 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) LL3_02939 ENOG4105C10 Electron transfer flavoprotein LL3_02940 ENOG4105BZJ Electron transfer flavoprotein LL3_02941 ENOG41060WC Enoyl-CoA hydratase LL3_02942 ENOG4107Z3H Transcriptional regulator, TetR family LL3_02943 ENOG4105CEY Amp-dependent synthetase and ligase LL3_02944 ENOG4108YV3 Protein of unknown function (DUF2711) LL3_02947 ENOG4105C98 muts2 protein LL3_02948 ENOG4105DCG PHP domain protein LL3_02951 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LL3_02952 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LL3_02953 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LL3_02955 ENOG4108RWN rrna methyltransferase LL3_02956 ENOG41067MF small acid-soluble spore protein LL3_02958 ENOG4105CQB FAD linked oxidase domain protein LL3_02959 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) LL3_02961 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) LL3_02962 ENOG4105DRS transport system, permease LL3_02965 ENOG4108MDK Dehydrogenase LL3_02967 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase LL3_02968 ENOG4105EF1 ribulokinase LL3_02970 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase LL3_02971 ENOG4105CN9 Peptidase m42 family protein LL3_02973 ENOG410696E Membrane LL3_02974 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LL3_02975 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LL3_02976 ENOG41067MG lrgb family LL3_02978 ENOG4105DY9 regulatoR LL3_02979 ENOG4108HRK Histidine kinase LL3_02981 ENOG4105U0R haloacid dehalogenase-like hydrolase LL3_02982 ENOG4105C22 threonyL-tRNA synthetase LL3_02984 ENOG4108TDW sporulation protein YtxC LL3_02989 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) LL3_02990 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LL3_02991 ENOG4105KVH Transcriptional regulator LL3_02992 ENOG4105F27 Major Facilitator LL3_02993 ENOG4105CV8 reductase LL3_02994 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LL3_02996 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LL3_02997 ENOG4105C2M dna polymerase I LL3_02998 ENOG4105BZU Histidine kinase LL3_02999 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LL3_03001 ENOG4108HMX isocitrate dehydrogenase (NADP) LL3_03002 ENOG4105BZN citrate synthase LL3_03004 ENOG4108REF Sporulation integral membrane protein ytvi LL3_03005 ENOG4105FS0 cytoplasmic membrane protein LL3_03006 ENOG4105CA9 Pyruvate kinase LL3_03007 ENOG4105CTQ phosphohexokinase LL3_03008 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) LL3_03009 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) LL3_03011 ENOG4105C6K Malic enzyme LL3_03012 ENOG4105C0B DNA polymerase III (alpha subunit) LL3_03013 ENOG4105VV2 LL3_03015 ENOG4106EVM LL3_03016 ENOG4105SFS phosphoesterase RecJ domain protein LL3_03019 ENOG4105E8R UPF0173 metal-dependent hydrolase LL3_03022 ENOG4105CH7 arginosuccinase LL3_03023 ENOG4105CDH Citrulline--aspartate ligase LL3_03024 ENOG4105EPU Molybdenum cofactor synthesis domain protein LL3_03025 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LL3_03027 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) LL3_03028 ENOG4105KBJ sporulation protein ytfj LL3_03030 ENOG4105VK3 rdd domain containing protein LL3_03031 ENOG4105D07 Signal peptide peptidase, SppA LL3_03032 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LL3_03033 ENOG4105EFZ amidohydrolase LL3_03034 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) LL3_03036 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LL3_03042 ENOG4105U5Y Transcriptional regulator LL3_03044 ENOG4105BZU Histidine kinase LL3_03046 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) LL3_03047 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LL3_03048 ENOG4108Z0Z intracellular protease Pfpi family LL3_03053 ENOG4108NGU Transcriptional regulator LL3_03054 ENOG4108UMN azlc family LL3_03057 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) LL3_03059 ENOG4105F1V Acetoin utilization protein LL3_03060 ENOG4105W87 Cbs domain LL3_03061 ENOG4105DGU Histone deacetylase LL3_03062 ENOG4105ER2 Ompa motb domain protein LL3_03063 ENOG4107R0U MotA TolQ exbB proton channel LL3_03064 ENOG4105ETE Transcriptional regulator (LacI family LL3_03066 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase LL3_03070 ENOG4105DFU Cell wall formation (By similarity) LL3_03073 ENOG4108VDD TRNA binding domain protein LL3_03076 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ LL3_03079 ENOG4105C6K Malic enzyme LL3_03080 ENOG4105C8F Beta-lactamase domain protein LL3_03081 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LL3_03083 ENOG4108V15 phosphotransferase enzyme family LL3_03086 ENOG4107F58 2'-5' rna ligase LL3_03087 ENOG4105C6T cysteine synthase LL3_03088 ENOG4107QSE Dipeptidase LL3_03089 ENOG4105C7N Xanthine uracil vitamin C permease LL3_03092 ENOG4105YW5 deoR family transcriptional regulator LL3_03095 ENOG4105CBX hi0933 family LL3_03097 ENOG4105C94 Transporter LL3_03102 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component LL3_03103 ENOG4105I1K ABC transporter LL3_03106 ENOG41085GJ domain protein LL3_03107 ENOG4105C8T Leucyl-tRNA synthetase LL3_03110 ENOG4105BZU Histidine kinase LL3_03111 ENOG410605W Major Facilitator LL3_03114 ENOG4105C19 ABC transporter LL3_03115 ENOG4105EWM Histidine kinase LL3_03117 ENOG4107R34 abc transporter permease protein LL3_03118 ENOG4105C19 ABC transporter LL3_03122 ENOG4105DVE abc transporter atp-binding protein LL3_03123 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family LL3_03126 ENOG4105N5T Radical SAM Protein LL3_03130 ENOG4105E8V Alpha Beta Hydrolase Fold protein LL3_03131 ENOG4108Z0R Transferase LL3_03132 ENOG4105C85 amino acid LL3_03133 ENOG4105CAQ asparagine synthetase LL3_03134 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LL3_03135 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase LL3_03138 ENOG4105D2X ABC transporter substrate-binding protein LL3_03140 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component LL3_03143 ENOG4108RMU ferritin dps family protein LL3_03146 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) LL3_03147 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) LL3_03148 ENOG4108V2W Carbonate dehydratase LL3_03149 ENOG4105NRA 50s ribosomal protein l31 type b LL3_03154 ENOG4105DTQ mandelate racemase muconate lactonizing LL3_03155 ENOG4105CEY Amp-dependent synthetase and ligase LL3_03156 ENOG4108IPT Naphthoate synthase LL3_03157 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) LL3_03158 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) LL3_03159 ENOG4105E4F Isochorismate synthase LL3_03163 ENOG4105N67 Proton-coupled thiamine transporter YuaJ LL3_03164 ENOG4105DZ6 Band 7 protein LL3_03166 ENOG4106DF1 LL3_03167 ENOG4108VNY MOSC domain protein LL3_03168 ENOG4108JB8 alcohol dehydrogenase LL3_03169 ENOG4105C26 Dehydrogenase LL3_03170 ENOG4105TRT Transcriptional regulator LL3_03173 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LL3_03175 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LL3_03181 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) LL3_03184 ENOG4105EE0 oxidoreductase LL3_03185 ENOG4108Z0Z intracellular protease Pfpi family LL3_03186 ENOG4105C8Q Methyl-accepting chemotaxis LL3_03187 ENOG4105C8Q Methyl-accepting chemotaxis LL3_03188 ENOG4105C8Q Methyl-accepting chemotaxis LL3_03189 ENOG4105C8Q Methyl-accepting chemotaxis LL3_03192 ENOG4105EA8 2-Nitropropane dioxygenase LL3_03195 ENOG4105C37 (CBS) domain LL3_03198 ENOG4107PBV potassium channel LL3_03199 ENOG4107PBV potassium channel LL3_03202 ENOG4107QYV phosphohexose isomerase LL3_03205 ENOG4107QW4 alcohol dehydrogenase LL3_03207 ENOG4105WG9 Conserved Protein LL3_03209 ENOG4105CHM Aminotransferase LL3_03210 ENOG4108ZB6 transcriptional regulator AsnC family LL3_03211 ENOG4108MUZ hydrolase LL3_03213 ENOG4105C87 Aminotransferase class I and II LL3_03214 ENOG4108HGU Histidine kinase LL3_03215 ENOG4105Y38 Kinase-associated protein B LL3_03218 ENOG4105BZ4 penicillin-binding protein LL3_03219 ENOG4105KIR Thiol-disulfide oxidoreductase dcc LL3_03222 ENOG4108MRH transcriptional regulatory protein LL3_03223 ENOG4105DIH basic membrane LL3_03225 ENOG4108JQ9 ABC transporter LL3_03226 ENOG4105UIB (ABC) transporter LL3_03229 ENOG4105D65 subunit l LL3_03230 ENOG4105HC0 Na H antiporter LL3_03231 ENOG4108ZE9 Monovalent cation H antiporter subunit C LL3_03232 ENOG4108JPZ Monovalent cation H antiporter subunit D LL3_03233 ENOG4105SC1 monovalent cation H antiporter subunit E LL3_03235 ENOG4105KJM monovalent cation h antiporter subunit g LL3_03236 ENOG4105KA0 thioesterase Superfamily protein LL3_03238 ENOG4105BZU Histidine kinase LL3_03244 ENOG4105D58 Diguanylate phosphodiesterase LL3_03245 ENOG4105DAP Nicotinate phosphoribosyltransferase LL3_03250 ENOG4105C02 permease LL3_03253 ENOG410904N short-chain dehydrogenase reductase LL3_03261 ENOG4108K8K Transcriptional regulator LL3_03262 ENOG4105DCF alanine dehydrogenase LL3_03264 ENOG4105WQT MbtH domain protein LL3_03265 ENOG4105CEY Amp-dependent synthetase and ligase LL3_03266 ENOG4105WQI isochorismatase LL3_03267 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase LL3_03268 ENOG4105E4F Isochorismate synthase LL3_03269 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase LL3_03270 ENOG4105NIV Esterase LL3_03274 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) LL3_03276 ENOG41069ER domain protein LL3_03279 ENOG4105CEP NADH dehydrogenase LL3_03283 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) LL3_03286 ENOG4105CJ1 ABC, transporter LL3_03291 ENOG4105D9U N-acetyltransferase LL3_03292 ENOG4105D9U N-acetyltransferase LL3_03293 ENOG4108VHC Short-chain dehydrogenase reductase Sdr LL3_03294 ENOG4108YX9 iron--sulfur cluster insertion protein erpA LL3_03295 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) LL3_03297 ENOG4105ZKE UPF0349 protein LL3_03300 ENOG41083MR nifu domain-containing protein LL3_03301 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein LL3_03302 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) LL3_03303 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) LL3_03304 ENOG4105D6E homoserine dehydrogenase LL3_03307 ENOG4108W5N phosphatidylglycerophosphatase a LL3_03308 ENOG4105D4U had-superfamily hydrolase, subfamily iia LL3_03310 ENOG4105MMD transcriptional regulator LL3_03311 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) LL3_03312 ENOG4105FAA peptidase M23 LL3_03313 ENOG4108YTE sporulation protein YunB LL3_03314 ENOG4107R8B 5'-nucleotidase LL3_03316 ENOG4105I3N Conserved Protein LL3_03318 ENOG4105CD3 dihydroorotase LL3_03319 ENOG4105G9B Transcriptional regulator LL3_03321 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) LL3_03324 ENOG4105C5R Aminotransferase LL3_03326 ENOG4108K8S endonuclease I LL3_03327 ENOG4108IJ9 (ABC) transporter LL3_03328 ENOG4105FDP GntR family transcriptional regulator LL3_03329 ENOG4108KPW sugar kinase LL3_03330 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component LL3_03331 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component LL3_03332 ENOG4105XN3 extracellular solute-binding protein family 1 LL3_03333 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine LL3_03339 ENOG4105PKS Excinuclease abc c subunit domain protein LL3_03340 ENOG4107VFR oxidoreductase LL3_03341 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LL3_03344 ENOG41083Q9 chitosanase LL3_03346 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase LL3_03350 ENOG41068G1 LL3_03352 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LL3_03354 ENOG4108FKH Transglycosylase SLT domain LL3_03375 ENOG4105C2M dna polymerase I LL3_03382 ENOG4108IMY Transcriptional regulator LL3_03384 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LL3_03385 ENOG4105DIW FeS assembly protein SUFB LL3_03386 ENOG4108UNV SUF system FeS assembly protein, NifU family LL3_03387 ENOG4105C9B Cysteine desulfurase LL3_03388 ENOG4105JRK feS assembly protein SufD LL3_03389 ENOG4105C3K feS assembly ATPase SufC LL3_03392 ENOG4105D01 (LipO)protein LL3_03393 ENOG4108UMI ABC transporter, permease LL3_03394 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LL3_03400 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) LL3_03401 ENOG41080E8 Transcriptional regulator, Spx MgsR family LL3_03402 ENOG4105C1G acyl-Coa dehydrogenase LL3_03403 ENOG4105CHU acetyl-coa acetyltransferase LL3_03409 ENOG41067TZ transcriptional regulator, MarR family LL3_03410 ENOG4105C0R drug resistance transporter emrb qaca subfamily LL3_03415 ENOG4105E0A ABC, transporter LL3_03418 ENOG4105E1F short-chain dehydrogenase reductase LL3_03419 ENOG4105HUF DNA protection during starvation protein LL3_03420 ENOG4105C0H protease LL3_03423 ENOG4105F3H Histidine kinase LL3_03425 ENOG41067SE Tetr family transcriptional regulator LL3_03426 ENOG4105C9Q fumarate hydratase class II LL3_03431 ENOG4105WH1 Two component transcriptional regulator luxr family LL3_03432 ENOG4105ENE Histidine kinase LL3_03435 ENOG41087YS Phage shock protein A LL3_03438 ENOG4108WBT adenosyltransferase LL3_03439 ENOG4105E0A ABC, transporter LL3_03440 ENOG4105EHG Permease protein LL3_03441 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) LL3_03442 ENOG4105EWI Short-chain dehydrogenase reductase Sdr LL3_03443 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein LL3_03445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LL3_03448 ENOG4106DF4 Sigma-70, region 4 LL3_03450 ENOG4105F0F Oxalate decarboxylase LL3_03452 ENOG4105E0A ABC, transporter LL3_03453 ENOG4105EHG Permease protein LL3_03454 ENOG4105DQ5 transport system permease protein LL3_03456 ENOG4105JQZ Methyltransferase LL3_03457 ENOG4105D5Q Arginine ornithine antiporter LL3_03459 ENOG4107K5X Membrane-bound metal-dependent hydrolase LL3_03460 ENOG4107QZ2 Sulfatase LL3_03461 ENOG4107QZ2 Sulfatase LL3_03462 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family LL3_03463 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein LL3_03464 ENOG4105E0C molybdate abc transporter LL3_03465 ENOG4105WH1 Two component transcriptional regulator luxr family LL3_03467 ENOG4105CJ1 ABC, transporter LL3_03469 ENOG4108KYE ABC-2 type transporter LL3_03472 ENOG4105EEQ Na H antiporter LL3_03473 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) LL3_03474 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) LL3_03475 ENOG4105EEM helicase LL3_03476 ENOG4105EN6 Membrane LL3_03479 ENOG4107ZQN disulfide bond LL3_03480 ENOG4105C59 p-type ATPase LL3_03481 ENOG4105C59 p-type ATPase LL3_03482 ENOG410681U heavy metal transport detoxification protein LL3_03483 ENOG4105VPX protein, conserved in bacteria LL3_03484 ENOG4105D9R oxidoreductase LL3_03485 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LL3_03488 ENOG4105DEN Luciferase family LL3_03489 ENOG4105CDA abc transporter atp-binding protein LL3_03494 ENOG4108XSB acetyltransferase, (GNAT) family LL3_03495 ENOG4108KSA LysR family transcriptional regulator LL3_03496 ENOG4105EWI Short-chain dehydrogenase reductase Sdr LL3_03497 ENOG41067XF inhibitor LL3_03498 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LL3_03499 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LL3_03501 ENOG4105XZU Preprotein translocase, subunit SecG LL3_03505 ENOG4105KVH Transcriptional regulator LL3_03510 ENOG4105DA5 (ABC) transporter LL3_03511 ENOG4105R40 Glycine betaine carnitine choline LL3_03512 ENOG4108HQR Glycine betaine LL3_03513 ENOG4105E90 ABC transporter LL3_03514 ENOG4108IJ8 ABC transporter LL3_03515 ENOG4107HG4 Transcriptional regulator LL3_03516 ENOG4105R40 Glycine betaine carnitine choline LL3_03517 ENOG4108HQR Glycine betaine LL3_03518 ENOG4105E90 ABC transporter LL3_03519 ENOG4108IJ8 ABC transporter LL3_03520 ENOG4107HG4 Transcriptional regulator LL3_03521 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein LL3_03523 ENOG4105T65 Membrane-associated protein LL3_03524 ENOG4108W0I acetyltransferase LL3_03527 ENOG4105FJR Lmbe family LL3_03531 ENOG4108IAJ Nad-dependent epimerase dehydratase LL3_03532 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LL3_03533 ENOG4107QQG Dehydrogenase LL3_03534 ENOG4105IIU Aminopeptidase LL3_03536 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) LL3_03537 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LL3_03538 ENOG4105CP7 Triose-phosphate isomerase LL3_03539 ENOG4105BZA Phosphoglycerate kinase LL3_03541 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LL3_03545 ENOG4105CMD Transcriptional regulator, GntR family LL3_03546 ENOG4105DEN Luciferase family LL3_03547 ENOG4105GZI Transcriptional regulator LL3_03548 ENOG4107RT3 EamA-like transporter family LL3_03553 ENOG4106KNT transcriptional regulator LL3_03554 ENOG4105CMG Carbohydrate kinase LL3_03555 ENOG4105C6Z Gluconate LL3_03557 ENOG4107QR9 Iron-sulfur cluster binding protein LL3_03558 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) LL3_03560 ENOG4105JXH GntR family transcriptional regulator LL3_03561 ENOG4105DAA L-lactate LL3_03562 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LL3_03564 ENOG4108ZPC Polysaccharide pyruvyl transferase LL3_03565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LL3_03566 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family LL3_03567 ENOG4105D3Q Sugar transferase LL3_03569 ENOG4105K64 Glycosyl transferase, family 2 LL3_03571 ENOG4107QRS glycosyltransferase group 2 family protein LL3_03572 ENOG41068W6 Capsular polysaccharide biosynthesis protein LL3_03573 ENOG4108KMV Glycosyl transferase (Group 1 LL3_03574 ENOG4105K64 Glycosyl transferase, family 2 LL3_03575 ENOG4108PQP glycosyl transferase group 1 LL3_03577 ENOG4108QV3 biosynthesis protein LL3_03578 ENOG4105HTX biosynthesis protein LL3_03580 ENOG4105EBR Carboxylesterase LL3_03582 ENOG4105NAE bifunctional deaminase-reductase domain protein LL3_03583 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) LL3_03586 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 LL3_03587 ENOG4105PY6 Phenolic acid decarboxylase LL3_03588 ENOG4105NI3 Protein of unknown function (DUF3237) LL3_03594 ENOG4108HKT sucrose-6-phosphate hydrolase LL3_03595 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) LL3_03597 ENOG4105ETE Transcriptional regulator (LacI family LL3_03598 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LL3_03599 ENOG4108KAM Transcriptional regulator LL3_03600 ENOG4105C7F AcnD-accessory protein PrpF LL3_03603 ENOG4108URH decarboxylase LL3_03604 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain LL3_03605 ENOG4105CHH sulfate transporter LL3_03606 ENOG4108V2W Carbonate dehydratase LL3_03608 ENOG4105C5I Dehydrogenase LL3_03609 ENOG4105GGE ribonuclease LL3_03610 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase LL3_03611 ENOG4105KRI phosphocarrier protein (HPr LL3_03612 ENOG4105CIE May be required for sporulation (By similarity) LL3_03613 ENOG4105CHW UPF0052 protein LL3_03614 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LL3_03615 ENOG4108Z4K mutator MutT protein LL3_03617 ENOG4105C3M thioredoxin reductase LL3_03622 ENOG4105BZU Histidine kinase LL3_03623 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_03624 ENOG4105BZ1 (ABC) transporter LL3_03625 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase LL3_03626 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) LL3_03627 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase LL3_03628 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) LL3_03629 ENOG4105ECC imidazole-glycerol-phosphate dehydratase LL3_03630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) LL3_03631 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) LL3_03632 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) LL3_03634 ENOG4108S4C acetyltransferase LL3_03635 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LL3_03637 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) LL3_03638 ENOG4105CE4 GlcNAc 6-P deacetylase LL3_03639 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LL3_03640 ENOG4105FDP GntR family transcriptional regulator LL3_03641 ENOG4105J7D transcriptional regulator LL3_03642 ENOG41088CQ domain protein LL3_03643 ENOG41086DT Membrane protein of unknown function LL3_03644 ENOG41067S9 phage shock protein C, PspC LL3_03645 ENOG4108PY7 LL3_03648 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LL3_03649 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) LL3_03652 ENOG4105MKU Transcriptional regulator LL3_03658 ENOG4105CN1 protease LL3_03659 ENOG4108M26 parallel beta-helix repeat protein LL3_03660 ENOG4105CRP Part of the ABC transporter FtsEX involved in LL3_03661 ENOG4105CAK Cell division ATP-binding protein ftsE LL3_03664 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) LL3_03665 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LL3_03666 ENOG4105MS2 ribosomal subunit Interface protein LL3_03669 ENOG4105MQ3 flagellar protein FliS LL3_03670 ENOG4107RT6 flagellar hook-associated LL3_03671 ENOG4105I03 Flagellin LL3_03672 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) LL3_03673 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) LL3_03675 ENOG4105DTJ flagellar hook-associated protein LL3_03676 ENOG4105E1Q flagellar hook-associated protein LL3_03679 ENOG4105RU3 LL3_03680 ENOG41081UC Inherit from COG: Competence protein LL3_03684 ENOG4105WH1 Two component transcriptional regulator luxr family LL3_03685 ENOG4105BZU Histidine kinase LL3_03686 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LL3_03687 ENOG4108KGH TRANSCRIPTIONal LL3_03688 ENOG4105ESV Glycosyl transferase, family 4 LL3_03689 ENOG4107EF8 Glycosyl transferase (Group 1 LL3_03692 ENOG4105QZI O-Antigen Polymerase LL3_03693 ENOG4105C6Y Udp-glucose 6-dehydrogenase LL3_03694 ENOG4107RA4 Glycosyl transferase (Group 1 LL3_03695 ENOG4105PSV Polysaccharide Biosynthesis Protein LL3_03696 ENOG4105D3Q Sugar transferase LL3_03697 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LL3_03698 ENOG4105JFG SpoIID LytB domain protein LL3_03700 ENOG4108KGH TRANSCRIPTIONal LL3_03701 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LL3_03703 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LL3_03704 ENOG4105EY8 ABC transporter LL3_03706 ENOG4107SJB teichoic acid biosynthesis LL3_03707 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) LL3_03708 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase LL3_03710 ENOG4107RZX Teichoic acid biosynthesis protein LL3_03712 ENOG4105DG6 mannose-6-phosphate isomerase LL3_03716 ENOG4108NHD germination protein LL3_03717 ENOG4108SHN Glycosyl transferase, family 2 LL3_03718 ENOG4105C54 Major Facilitator superfamily LL3_03719 ENOG4108KGH TRANSCRIPTIONal LL3_03721 ENOG4105J7I hydrolase LL3_03722 ENOG4106UBQ LL3_03723 ENOG4105K4H Nlp p60 protein LL3_03725 ENOG4105PNM synthesis protein LL3_03727 ENOG4105N98 Capsule biosynthesis protein capB LL3_03733 ENOG4105ETE Transcriptional regulator (LacI family LL3_03734 ENOG4108RVA ribokinase LL3_03735 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LL3_03736 ENOG4105C2J ABC transporter LL3_03737 ENOG4105CNN ABC, transporter LL3_03738 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator LL3_03740 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein LL3_03741 ENOG4107FQX Alpha-acetolactate decarboxylase LL3_03743 ENOG4107RSM transcriptional regulator LL3_03746 ENOG4106UIA LL3_03751 ENOG4107XC4 flavin reductase domain protein, FMN-binding LL3_03753 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) LL3_03756 ENOG4105CAH Chromate LL3_03757 ENOG4105FGV Chromate LL3_03768 ENOG4108XI2 Domain of unknown function (DUF1963) LL3_03769 ENOG4105C6Y Udp-glucose 6-dehydrogenase LL3_03771 ENOG4108RB3 Capsular polysaccharide biosynthesis protein LL3_03772 ENOG4107YJ4 chain length determinant protein LL3_03773 ENOG4105HTX biosynthesis protein LL3_03775 ENOG4105KBK Zinc finger, swim domain protein LL3_03776 ENOG4105C0D helicase LL3_03777 ENOG410667J hydrolase LL3_03778 ENOG4105E98 transcriptional regulator DeoR family LL3_03779 ENOG4105Z8H single-stranded DNA-binding protein LL3_03782 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LL3_03783 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LL3_03785 ENOG4105CGA flagellar basal-body rod protein FlgG LL3_03788 ENOG4105DFF Rod shape-determining protein mreb LL3_03789 ENOG4105MT0 Sporulation transcriptional regulator spoiiid LL3_03790 ENOG4107MII Sugar-specific transcriptional regulator TrmB LL3_03791 ENOG4105CZM Major Facilitator LL3_03792 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease LL3_03793 ENOG41080V3 Major Facilitator superfamily LL3_03794 ENOG4105D3W isochorismatase LL3_03795 ENOG4105BZU Histidine kinase LL3_03797 ENOG4105CNI cell division protein FtsW LL3_03798 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase LL3_03800 ENOG4105FRN stage II sporulation protein LL3_03801 ENOG4107TCE N-acetyltransferase LL3_03805 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LL3_03807 ENOG4106BRK LL3_03808 ENOG4108RYK Nad-dependent epimerase dehydratase LL3_03809 ENOG4108Z40 Transcriptional regulator LL3_03810 ENOG4105CQM Urea amidohydrolase subunit alpha LL3_03811 ENOG4105KI2 Urea amidohydrolase subunit beta LL3_03812 ENOG4108YZ9 Urea amidohydrolase subunit gamma LL3_03817 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LL3_03818 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) LL3_03820 ENOG4108TF4 von Willebrand factor, type A LL3_03823 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LL3_03825 ENOG4106778 Protein of unknown function (DUF1146) LL3_03827 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) LL3_03828 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) LL3_03829 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LL3_03830 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LL3_03831 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LL3_03834 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) LL3_03837 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LL3_03838 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) LL3_03839 ENOG4108UIC UPF0340 protein LL3_03840 ENOG4108YZG isomerase LL3_03841 ENOG4107WAU Protein tyrosine phosphatase LL3_03842 ENOG410815N Probably functions as a manganese efflux pump (By similarity) LL3_03843 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LL3_03845 ENOG4108ZXQ stage ii sporulation protein r LL3_03848 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LL3_03849 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LL3_03850 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase LL3_03852 ENOG4107TT2 Auxin Efflux Carrier LL3_03853 ENOG4105C6K Malic enzyme LL3_03854 ENOG4107104 thymidine kinase LL3_03855 ENOG41082DI 50s ribosomal protein l31 LL3_03856 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) LL3_03857 ENOG4105CBT Fructose-1,6-bisphosphatase LL3_03858 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LL3_03860 ENOG4105D2N Aldolase LL3_03861 ENOG410812K response regulator receiver protein LL3_03863 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LL3_03865 ENOG4105DF6 Fe-S oxidoreductase LL3_03867 ENOG4105E5J UV damage endonuclease LL3_03869 ENOG4105BZ1 (ABC) transporter LL3_03870 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LL3_03872 ENOG4105R3A Nitrate reductase LL3_03873 ENOG4108IUE nitrate reductase beta subunit LL3_03877 ENOG4107V6Q Cyclic nucleotide-binding domain LL3_03879 ENOG4105C75 arginyL-tRNA synthetase LL3_03880 ENOG410684U Domain of unknown function (DUF1934) LL3_03883 ENOG4107JM4 Tetratricopeptide repeat LL3_03885 ENOG4105CYW agmatinase LL3_03886 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) LL3_03887 ENOG4105BZ4 penicillin-binding protein LL3_03889 ENOG4108XFG YwhD family LL3_03890 ENOG4108Z4T Peptidase M50 LL3_03891 ENOG41069HH 4-oxalocrotonate tautomerase LL3_03892 ENOG41067TZ transcriptional regulator, MarR family LL3_03893 ENOG4105CUB amino acid LL3_03895 ENOG4105DCI Phosphohydrolase LL3_03898 ENOG4108VCI transcription factor, rsfa family LL3_03899 ENOG4105K7K Transcriptional regulator LL3_03902 ENOG4108TU7 Inherit from COG: (ABC) transporter LL3_03907 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) LL3_03908 ENOG4105DUM transcriptional regulator, lysR family LL3_03909 ENOG4105HMI Membrane LL3_03910 ENOG4108IJ2 phosphate acetyltransferase LL3_03911 ENOG4107JTW chlorite dismutase LL3_03913 ENOG4105CHM Aminotransferase LL3_03915 ENOG4108M32 ATP-grasp domain LL3_03918 ENOG41061WN bacilysin biosynthesis protein LL3_03919 ENOG4105FCW Major Facilitator superfamily LL3_03920 ENOG4105C2C drug resistance transporter, Bcr CflA LL3_03923 ENOG4105C26 Dehydrogenase LL3_03925 ENOG4105D82 Glutamate dehydrogenase LL3_03927 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase LL3_03928 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase LL3_03929 ENOG4105C1B dTDP-glucose 4-6-dehydratase LL3_03930 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) LL3_03931 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG LL3_03932 ENOG4107TY6 Acylneuraminate cytidylyltransferase LL3_03934 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD LL3_03935 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LL3_03942 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) LL3_03943 ENOG4108RJ9 Glycosyl transferase, family 2 LL3_03945 ENOG4105DWF phosphomethylpyrimidine kinase LL3_03948 ENOG4105C5Y PTS System LL3_03951 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin LL3_03952 ENOG4105DEN Luciferase family LL3_03953 ENOG4105D29 Helix-turn-helix type 11 domain protein LL3_03954 ENOG4107EXU Short-chain dehydrogenase reductase Sdr LL3_03957 ENOG4108DBC nitroreductase LL3_03959 ENOG4105I4A GCN5-related N-acetyltransferase LL3_03964 ENOG4105BZ9 Cytochrome C oxidase, subunit I LL3_03965 ENOG4105E2S oxidase) subunit II LL3_03966 ENOG4107BMA Transglycosylase associated protein LL3_03968 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) LL3_03969 ENOG4105WH5 Teichoic acid glycosylation protein LL3_03975 ENOG4107ZXU DSBA oxidoreductase LL3_03976 ENOG4105DBE peroxidase LL3_03977 ENOG410650H (LipO)protein LL3_03978 ENOG4107SJW iron permease, FTR1 LL3_03979 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LL3_03980 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LL3_03981 ENOG4105CMU LysR family (Transcriptional regulator LL3_03982 ENOG4105VAW lrga family LL3_03983 ENOG41067MG lrgb family LL3_03986 ENOG4107TXC Transcriptional regulator LL3_03988 ENOG4105DR4 Methyltransferase LL3_03990 ENOG4105CK1 PTS System LL3_03991 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin LL3_03992 ENOG4105X1N Glycosyl transferase family 8 LL3_03996 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase LL3_03999 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) LL3_04000 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein LL3_04001 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) LL3_04002 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD LL3_04003 ENOG4105CM2 brancheD-chain amino acid aminotransferase LL3_04004 ENOG4105F8D glycoside hydrolase family 4 LL3_04005 ENOG4105VCP PTS System LL3_04006 ENOG4105CK1 PTS System LL3_04007 ENOG4105VZJ PTS System LL3_04012 ENOG4105DQ5 transport system permease protein LL3_04013 ENOG4105EHG Permease protein LL3_04015 ENOG41082YX Transcriptional regulator, arsr family LL3_04016 ENOG4107R5R arsenical pump membrane protein LL3_04017 ENOG4105VZJ PTS System LL3_04018 ENOG4105VCP PTS System LL3_04019 ENOG4105CK1 PTS System LL3_04020 ENOG4105CS2 ec 3.2.1.21 LL3_04021 ENOG4105EVU fructokinase LL3_04022 ENOG4105DG6 mannose-6-phosphate isomerase LL3_04024 ENOG4105CH6 catalase LL3_04025 ENOG4107QHE Choloylglycine hydrolase LL3_04026 ENOG4105ETS cytosine purines uracil thiamine allantoin LL3_04027 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LL3_04028 ENOG4108JJ8 (ABC) transporter LL3_04029 ENOG4108JJ9 ABC, transporter LL3_04030 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LL3_04031 ENOG4105C4M (Ubiquinol oxidase) subunit I LL3_04032 ENOG4105D2K citrate carrier protein LL3_04033 ENOG4107BJW polysaccharide deacetylase LL3_04036 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) LL3_04038 ENOG4105CMR udp-glucose 4-epimerase LL3_04040 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LL3_04046 ENOG4105DHI Methyltransferase LL3_04052 ENOG4105CH6 catalase LL3_04053 ENOG4105D4T Citrate transporter LL3_04055 ENOG4105CID antiterminator LL3_04056 ENOG4105DEU major facilitator superfamily LL3_04057 ENOG4105C1J atp-dependent rna helicase LL3_04068 ENOG4108NR7 pectate lyase LL3_04070 ENOG4107YZX Universal stress protein LL3_04071 ENOG4105CS2 ec 3.2.1.21 LL3_04072 ENOG4105C5Y PTS System LL3_04075 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LL3_04079 ENOG4106Z5D Glycoside Hydrolase Family 43 LL3_04081 ENOG4105C84 Histidine ammonia-lyase LL3_04082 ENOG4105CGP Urocanate hydratase LL3_04083 ENOG4105CI2 imidazolone-5-propionate hydrolase LL3_04084 ENOG4107W25 arginase agmatinase formiminoglutamase LL3_04086 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) LL3_04087 ENOG4105D9N nucleoside LL3_04088 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LL3_04089 ENOG4107RHR regulatoR LL3_04090 ENOG410667J hydrolase LL3_04096 ENOG4108V5C ABC transporter LL3_04103 ENOG4105WZ4 isomerase LL3_04104 ENOG4105F0H myo-inositol catabolism protein LL3_04105 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) LL3_04107 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) LL3_04109 ENOG4105EDK PfkB domain protein LL3_04111 ENOG4105C26 Dehydrogenase LL3_04113 ENOG4105CPC Aldo Keto reductase LL3_04114 ENOG4107QNK )-transporter LL3_04115 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) LL3_04116 ENOG41061TZ Short-chain dehydrogenase reductase Sdr LL3_04117 ENOG4108S01 response regulator LL3_04118 ENOG4108ZGX Histidine kinase LL3_04119 ENOG4105ECK Fatty Acid Desaturase LL3_04120 ENOG4105ST3 Transcriptional regulator LL3_04121 ENOG4105C26 Dehydrogenase LL3_04122 ENOG4108ITS PQQ enzyme repeat LL3_04124 ENOG4105WAB arsR family transcriptional regulator LL3_04125 ENOG4105F27 Major Facilitator LL3_04126 ENOG41085PJ rdd domain containing protein LL3_04128 ENOG4105D3R alkyl hydroperoxide reductase LL3_04129 ENOG4108JU3 Alkyl hydroperoxide reductase LL3_04131 ENOG4105C85 amino acid LL3_04141 ENOG41090VF Stage v sporulation protein ac LL3_04142 ENOG4105CZ3 stage V sporulation protein ad LL3_04144 ENOG4108QY0 Membrane LL3_04146 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LL3_04147 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 LL3_04148 ENOG4108XHQ (2Fe-2S)-binding domain protein LL3_04150 ENOG4105C7W Xanthine dehydrogenase LL3_04152 ENOG4105XRQ Xanthine dehydrogenase accessory factor LL3_04158 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) LL3_04162 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) LL3_04163 ENOG4105CPC Aldo Keto reductase LL3_04164 ENOG4105WQG acetyltransferase LL3_04167 ENOG41066UZ arginase EC 3.5.3.1 LL3_04168 ENOG4108IQI permease LL3_04169 ENOG4105C8Y Acetylornithine aminotransferase LL3_04171 ENOG41082BM Transcriptional regulator, arsr family LL3_04172 ENOG4108JUB Transcriptional regulator LL3_04175 ENOG41062D9 Histidine kinase LL3_04176 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_04178 ENOG4105C0H protease LL3_04179 ENOG4105Q2H domain protein LL3_04182 ENOG4105BZU Histidine kinase LL3_04183 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LL3_04186 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LL3_04187 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase LL3_04189 ENOG4105CDU Replicative dna helicase LL3_04197 ENOG4105CGN Glycosyl transferase (Group 1 LL3_04201 ENOG4105BZR domain protein LL3_04202 ENOG4108XMW Membrane LL3_04205 ENOG4105KVH Transcriptional regulator LL3_04206 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase LL3_04207 ENOG4108UZ3 Transporter LL3_04208 ENOG4105EDQ levansucrase EC 2.4.1.10 LL3_04209 ENOG4108HKT sucrose-6-phosphate hydrolase LL3_04215 ENOG4108TVJ Nitroreductase LL3_04216 ENOG4105FS7 Transcriptional regulator LL3_04219 ENOG4108U05 Transcriptional regulator LL3_04220 ENOG41082BV acetyltransferase LL3_04221 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) LL3_04227 ENOG4107FCW Abortive infection protein LL3_04229 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase LL3_04231 ENOG4105CGK Exodeoxyribonuclease III LL3_04232 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LL3_04235 ENOG4108UUM single-stranded DNA-binding protein LL3_04236 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LL3_04237 ENOG4105C3G gtp-binding protein LL3_04238 ENOG4108J2R molybdopterin oxidoreductase LL3_04239 ENOG4105VDK protein, conserved in bacteria LL3_04242 ENOG4108ZDA Sporulation protein YyaC LL3_04243 ENOG4105FA0 parb-like partition protein LL3_04244 ENOG4107QJE Chromosome Partitioning Protein LL3_04247 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LL3_04248 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LL3_04251 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) LL3_p00005 ENOG410780I phosphoprotein phosphatase activity