locus-tag class description BSF20_00125 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BSF20_00130 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BSF20_00135 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BSF20_00140 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BSF20_00150 ENOG4108K88 Membrane BSF20_00160 ENOG4105E14 MotA TolQ exbB proton channel BSF20_00165 ENOG4105ER2 Ompa motb domain protein BSF20_00170 ENOG41090MY MarR family Transcriptional regulator BSF20_00175 ENOG4105BZU Histidine kinase BSF20_00185 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BSF20_00190 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BSF20_00195 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BSF20_00200 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BSF20_00210 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BSF20_00220 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BSF20_00225 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BSF20_00230 ENOG4105BZU Histidine kinase BSF20_00235 ENOG4108TGC Acyltransferase BSF20_00240 ENOG410900G Protein of unknown function (DUF421) BSF20_00250 ENOG4105D0M Protease HtpX homolog BSF20_00260 ENOG410681C small acid-soluble spore protein BSF20_00270 ENOG4108WZW RNA polymerase sigma BSF20_00275 ENOG4107TS3 membrane protein, TerC BSF20_00280 ENOG4107T5V SNARE associated Golgi BSF20_00290 ENOG4105FDF Could be involved in DNA repair (By similarity) BSF20_00295 ENOG4105DQE DNA ligase BSF20_00315 ENOG4105V75 Transcriptional regulator BSF20_00320 ENOG4105CJW magnesium transporter BSF20_00325 ENOG4105VRS hydrolase family 18 BSF20_00330 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BSF20_00335 ENOG4108JJB ABC transporter BSF20_00340 ENOG4108W7F transporter, permease BSF20_00350 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSF20_00355 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BSF20_00360 ENOG4108Y4K DNA-binding transcriptional activator BSF20_00365 ENOG4105D8G Major Facilitator superfamily BSF20_00375 ENOG4107TVC Glycosyl transferase, family 2 BSF20_00390 ENOG4108ZHJ Organic hydroperoxide resistance protein BSF20_00395 ENOG4105K56 Transcriptional regulator BSF20_00410 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BSF20_00415 ENOG4105CIY formyltetrahydrofolate deformylase BSF20_00420 ENOG41080TC multidrug resistance protein BSF20_00430 ENOG4108428 Inherit from COG: -acetyltransferase BSF20_00435 ENOG4108S4H thioesterase Superfamily protein BSF20_00440 ENOG4107TUM Amidinotransferase BSF20_00445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BSF20_00450 ENOG4108JQ7 (ABC) transporter BSF20_00455 ENOG4107SN7 NLP P60 protein BSF20_00460 ENOG4105DTQ mandelate racemase muconate lactonizing BSF20_00465 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BSF20_00475 ENOG4105C3U ABC transporter BSF20_00480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSF20_00485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSF20_00490 ENOG4108ME1 Peptidase M55 D-aminopeptidase BSF20_00500 ENOG4105C0H protease BSF20_00505 ENOG4105CKK Glycosyl transferase, family 2 BSF20_00510 ENOG4105EDW glycosyl transferase, family 39 BSF20_00520 ENOG4107R7I amino acid BSF20_00525 ENOG4107GRR phosphate transport regulator BSF20_00530 ENOG4105CJ3 phosphate transporter BSF20_00545 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BSF20_00575 ENOG41068G1 BSF20_00585 ENOG410906S phage-like element pbsx protein xkdt BSF20_00590 ENOG41066EA baseplate J family protein BSF20_00595 ENOG4105MFU Protein of unknown function (DUF2634) BSF20_00605 ENOG4105X7F BSF20_00610 ENOG4108WZM domain protein BSF20_00615 ENOG4108FKH Transglycosylase SLT domain BSF20_00615 ENOG4108FKH Transglycosylase SLT domain BSF20_00615 ENOG4108FKH Transglycosylase SLT domain BSF20_00620 ENOG4105MTC XkdN-like protein BSF20_00625 ENOG4105FR7 XkdM protein, phage-like element PBSX BSF20_00630 ENOG4105PQS phage protein BSF20_00645 ENOG41060SN BSF20_00670 ENOG4108MDF Phage Portal Protein BSF20_00675 ENOG4105IG6 Phage terminase, large subunit BSF20_00680 ENOG4108TFU terminase (Small subunit) BSF20_00720 ENOG410635T phage-like element pbsx protein BSF20_00725 ENOG4105K7W phage-related replication protein BSF20_00730 ENOG4105KWG Pfam:DUF1696 BSF20_00735 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BSF20_00750 ENOG4107TSN permease BSF20_00760 ENOG4105FDK ABC transporter BSF20_00765 ENOG4105F3H Histidine kinase BSF20_00770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSF20_00775 ENOG4105CTX dehydratase BSF20_00780 ENOG4107QZW Altronate oxidoreductase BSF20_00785 ENOG4107KJX Transcriptional regulator BSF20_00790 ENOG4105CT4 transporter BSF20_00795 ENOG4105D2H Uronic isomerase BSF20_00810 ENOG4105Q95 Cupin 2, conserved barrel domain protein BSF20_00820 ENOG4108IXI (ABC) transporter BSF20_00825 ENOG4105C4B ABC transporter, permease BSF20_00830 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BSF20_00840 ENOG41087PP glycosyltransferase MGT family BSF20_00845 ENOG4106A3M Cytochrome p-450 BSF20_00855 ENOG4108IEG Formate dehydrogenase Alpha subunit BSF20_00880 ENOG4105KT7 mgtC SapB transporter BSF20_00895 ENOG4105E98 transcriptional regulator DeoR family BSF20_00905 ENOG4105VCP PTS System BSF20_00910 ENOG4105CK1 PTS System BSF20_00915 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BSF20_00920 ENOG4105CMR udp-glucose 4-epimerase BSF20_00925 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BSF20_00940 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSF20_00955 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BSF20_00965 ENOG4106BHF BSF20_00990 ENOG4105C28 cystathionine BSF20_00995 ENOG4105C28 cystathionine BSF20_01005 ENOG4108ZMI UPF0477 protein BSF20_01020 ENOG4105CJ1 ABC, transporter BSF20_01040 ENOG4105ENA helicase BSF20_01090 ENOG4107A88 BSF20_01095 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BSF20_01100 ENOG4105DWF phosphomethylpyrimidine kinase BSF20_01105 ENOG4105D06 uba thif-type nad fad binding protein BSF20_01125 ENOG4108VEU Thiamine monophosphate synthase BSF20_01130 ENOG4105ETU transcriptional activator (TenA BSF20_01140 ENOG4107S1Q Phosphatase BSF20_01145 ENOG4105EMS pseudouridine synthase BSF20_01150 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BSF20_01165 ENOG4105MIX Adenylate cyclase BSF20_01170 ENOG4105E4C Lytic transglycosylase catalytic BSF20_01175 ENOG4108Z18 K06886 hemoglobin BSF20_01180 ENOG4105T58 Dithiol-disulfide isomerase BSF20_01185 ENOG4105DPN Oligoendopeptidase f BSF20_01195 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BSF20_01200 ENOG4108ZCF integral membrane protein BSF20_01205 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BSF20_01220 ENOG4108JQ7 (ABC) transporter BSF20_01230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSF20_01235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSF20_01240 ENOG4108J59 Extracellular solute-binding protein, family 5 BSF20_01245 ENOG4105C31 Tryptophanyl-tRNA synthetase BSF20_01265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSF20_01280 ENOG4108JQ7 (ABC) transporter BSF20_01285 ENOG4105C3U ABC transporter BSF20_01295 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSF20_01300 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BSF20_01315 ENOG4107RMD Basic membrane lipoprotein BSF20_01345 ENOG4105DBV ornithine carbamoyltransferase BSF20_01355 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BSF20_01360 ENOG4105C8Y Acetylornithine aminotransferase BSF20_01365 ENOG4105CAS nag kinase BSF20_01375 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BSF20_01385 ENOG4105IQ5 FAD linked oxidase domain protein BSF20_01390 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BSF20_01395 ENOG4105VG1 fes assembly suf system protein BSF20_01400 ENOG4108MXZ Esterase BSF20_01405 ENOG4108KP7 hydrolase BSF20_01410 ENOG41073B9 BSF20_01420 ENOG4107AYK membrAne BSF20_01425 ENOG4105EPR degv family BSF20_01430 ENOG4105C8Q Methyl-accepting chemotaxis BSF20_01435 ENOG4105DIH basic membrane BSF20_01440 ENOG4105QNR S1 RNA binding domain protein BSF20_01445 ENOG4108VPT UPF0234 protein BSF20_01455 ENOG4105MA6 gCN5-related N-acetyltransferase BSF20_01460 ENOG4105MYW Pentapeptide repeat protein BSF20_01465 ENOG4105SF0 DinB family BSF20_01470 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BSF20_01475 ENOG4105ETE Transcriptional regulator (LacI family BSF20_01480 ENOG4106HBX Transcriptional Regulator AraC Family BSF20_01485 ENOG4105UQX Mate efflux family protein BSF20_01495 ENOG4105CAQ asparagine synthetase BSF20_01515 ENOG4105ERH Fumarylacetoacetate hydrolase BSF20_01560 ENOG4105EYH Exonuclease BSF20_01570 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BSF20_01575 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BSF20_01580 ENOG4108QY0 Membrane BSF20_01590 ENOG4108IG5 Transcriptional regulator BSF20_01600 ENOG4108KK1 membrane protein AbrB duplication BSF20_01605 ENOG4108INS Transcriptional regulator BSF20_01610 ENOG4107SCK Monooxygenase BSF20_01625 ENOG41060YP BSF20_01630 ENOG4106CAD Protein of unknown function (DUF3311) BSF20_01635 ENOG4105E1V na solute symporter BSF20_01640 ENOG4105K8R UPF0145 protein BSF20_01645 ENOG4105X3H Excalibur domain protein BSF20_01655 ENOG4108ZMX Domain of unknown function (DU1801) BSF20_01665 ENOG4105XVF Competence transcription factor BSF20_01685 ENOG4106YBV Methyl-accepting chemotaxis BSF20_01690 ENOG4107ZYJ bioY protein BSF20_01695 ENOG4107F3J Amp-dependent synthetase and ligase BSF20_01705 ENOG4107TB6 phosphoglycerate mutase BSF20_01710 ENOG4108HUF Transporter BSF20_01725 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BSF20_01735 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_01745 ENOG4105DF9 Lipoate-protein, ligase BSF20_01750 ENOG4108RQ5 Beta-lactamase domain-containing protein BSF20_01755 ENOG4106AXD BSF20_01765 ENOG4105DER m42 family BSF20_01785 ENOG4105DQ6 Transposase BSF20_01790 ENOG4105ECB domain protein BSF20_01800 ENOG4105C1Q protoporphyrinogen oxidase BSF20_01805 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BSF20_01810 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BSF20_01815 ENOG4105BZ4 penicillin-binding protein BSF20_01820 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BSF20_01850 ENOG4105K59 histidine triad (HIT) protein BSF20_01855 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BSF20_01860 ENOG4105NBU tryptophan transport protein BSF20_01900 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BSF20_01910 ENOG4105EQI Metal Dependent Phosphohydrolase BSF20_01915 ENOG4106D4I domain protein BSF20_01920 ENOG4107VRP DNA repair exonuclease BSF20_01925 ENOG4105RHA ABC transporter, permease BSF20_01930 ENOG4108IUX (ABC) transporter BSF20_01940 ENOG4105CGU Enoyl-CoA hydratase BSF20_01950 ENOG4105NCW Trka-c domain protein BSF20_01955 ENOG4107S91 Sodium hydrogen exchanger BSF20_01965 ENOG4105D4P Coproporphyrinogen iii oxidase BSF20_01975 ENOG4105F1N DNA alkylation repair BSF20_01980 ENOG4105WZB UPF0342 protein BSF20_01985 ENOG4106MP8 UPF0754 membrane protein BSF20_01995 ENOG410839P BSF20_02015 ENOG4105BZ1 (ABC) transporter BSF20_02020 ENOG4105BZ1 (ABC) transporter BSF20_02030 ENOG4105IIP Membrane BSF20_02035 ENOG4105W1N transcriptional regulator BSF20_02040 ENOG4105F0I Aminotransferase BSF20_02045 ENOG4107VMI polysaccharide deacetylase BSF20_02050 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BSF20_02055 ENOG4105D64 Mechanosensitive ion channel BSF20_02060 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BSF20_02065 ENOG4105WMR Protein CrcB homolog BSF20_02075 ENOG4105C37 (CBS) domain BSF20_02080 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BSF20_02085 ENOG4105CHM Aminotransferase BSF20_02095 ENOG4105C37 (CBS) domain BSF20_02100 ENOG4105F6E Acyl-transferase BSF20_02105 ENOG4108AEY RNA polymerase sigma factor BSF20_02110 ENOG4105J37 BSF20_02120 ENOG4105C8J )-transporter BSF20_02125 ENOG4105CUB amino acid BSF20_02130 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSF20_02135 ENOG4105BZN citrate synthase BSF20_02150 ENOG4105G6Z alkaline phosphatase BSF20_02155 ENOG4105ED1 spovr family BSF20_02205 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BSF20_02210 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BSF20_02220 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BSF20_02225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSF20_02230 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BSF20_02235 ENOG4107YBY Hydrolase BSF20_02240 ENOG41080XP Cbs domain BSF20_02250 ENOG4108YBP pseudouridine synthase BSF20_02290 ENOG4105BZU Histidine kinase BSF20_02300 ENOG4105VEQ Cold shock protein BSF20_02305 ENOG4108TU7 Inherit from COG: (ABC) transporter BSF20_02310 ENOG4105CJ1 ABC, transporter BSF20_02315 ENOG4105CZV ABC transporter BSF20_02320 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BSF20_02335 ENOG4105CS1 NAD(P)H quinone oxidoreductase BSF20_02340 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSF20_02345 ENOG4105CW7 secretion protein, HlyD family BSF20_02350 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BSF20_02360 ENOG4105CYN Serine protein kinase BSF20_02380 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BSF20_02390 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BSF20_02405 ENOG4105VZ8 Transcriptional regulator BSF20_02410 ENOG4107D63 BSF20_02415 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BSF20_02425 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BSF20_02430 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BSF20_02435 ENOG4105E2Y ABC, transporter BSF20_02450 ENOG4108JQ7 (ABC) transporter BSF20_02455 ENOG4105C3U ABC transporter BSF20_02460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSF20_02470 ENOG4105DEF Extracellular solute-binding protein, family 5 BSF20_02480 ENOG4105DNP FAD linked oxidase domain protein BSF20_02485 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BSF20_02600 ENOG4105TUA UPF0295 protein BSF20_02605 ENOG4105G5W regulator Fur family BSF20_02610 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSF20_02615 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BSF20_02620 ENOG4107NBY Membrane BSF20_02625 ENOG4105BZ1 (ABC) transporter BSF20_02645 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BSF20_02650 ENOG4106BXE BSF20_02655 ENOG4105CEN a g-specific adenine glycosylase BSF20_02660 ENOG41067AE Membrane-bound metal-dependent hydrolase BSF20_02665 ENOG4105EJV Membrane BSF20_02670 ENOG4105CKK Glycosyl transferase, family 2 BSF20_02675 ENOG4105D74 hydrolase BSF20_02680 ENOG4106AKJ BSF20_02700 ENOG4108TCS Glutamyl endopeptidase BSF20_02710 ENOG4105F27 Major Facilitator BSF20_02720 ENOG410902V Modulates RecA activity (By similarity) BSF20_02725 ENOG4105ECP epimerase BSF20_02740 ENOG4107Y03 Nitroreductase BSF20_02745 ENOG4105JAB phenazine biosynthesis protein, phzf family BSF20_02755 ENOG410834F Transcriptional regulator BSF20_02760 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSF20_02765 ENOG4108YYS metal-dependent hydrolase (By similarity) BSF20_02780 ENOG4105H93 Acyltransferase family BSF20_02785 ENOG4105DYS nad(p)h dehydrogenase (quinone) BSF20_02790 ENOG4105U3E Transcriptional regulator BSF20_02795 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BSF20_02800 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BSF20_02810 ENOG4105BZ1 (ABC) transporter BSF20_02815 ENOG4105BZ1 (ABC) transporter BSF20_02820 ENOG4105CI1 PTS System BSF20_02825 ENOG4108Q3X Transcriptional regulator BSF20_02830 ENOG4105F8D glycoside hydrolase family 4 BSF20_02840 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BSF20_02850 ENOG4107QKR Dehydrogenase BSF20_02860 ENOG4107RUY (E1 component), alpha subunit BSF20_02880 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BSF20_02890 ENOG4105D7N magnesium and cobalt transport protein CorA BSF20_02900 ENOG4106KE4 Dehydrogenase BSF20_02920 ENOG4105D8X mechanosensitive ion channel BSF20_02930 ENOG4105UPD Calcium Proton BSF20_02935 ENOG4108ISG Major Facilitator BSF20_02940 ENOG4107U9T Pfam:Ribonuclease_BN BSF20_02950 ENOG4105KJF protein tyrosine phosphatase BSF20_02965 ENOG4105FF2 Type I DHQase BSF20_02970 ENOG4105E2X shikimate dehydrogenase BSF20_02975 ENOG4105ETE Transcriptional regulator (LacI family BSF20_02980 ENOG4107RKG DJ-1/PfpI family BSF20_02985 ENOG4105CGH 5'-nucleotidase BSF20_03000 ENOG4108RCM Nitroreductase BSF20_03005 ENOG4107414 GntR family transcriptional regulator BSF20_03010 ENOG4105CG3 alpha amylase, catalytic region BSF20_03015 ENOG4105C5Y PTS System BSF20_03055 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BSF20_03070 ENOG4108RPX mosc domain containing protein BSF20_03075 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BSF20_03100 ENOG4108MRH transcriptional regulatory protein BSF20_03110 ENOG4108Z6X (sortase) family BSF20_03120 ENOG4108VAC response regulator BSF20_03145 ENOG4107QPK )-transporter BSF20_03150 ENOG4108J20 pectate lyase BSF20_03165 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BSF20_03175 ENOG4105FDU atp-dependent rna helicase BSF20_03180 ENOG4105C5H ABC transporter BSF20_03185 ENOG4105DXB Major Facilitator superfamily BSF20_03190 ENOG4107SWG transcriptional regulator MERR family BSF20_03195 ENOG4105C5H ABC transporter BSF20_03200 ENOG4107TVC Glycosyl transferase, family 2 BSF20_03205 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSF20_03210 ENOG4105FKZ Methyl-accepting chemotaxis BSF20_03215 ENOG4105C26 Dehydrogenase BSF20_03220 ENOG4105CUB amino acid BSF20_03225 ENOG4105EU0 Major facilitator Superfamily BSF20_03230 ENOG41090R9 glycosyltransferase BSF20_03235 ENOG4107R51 Glycosyl transferase, family 2 BSF20_03240 ENOG41090R9 glycosyltransferase BSF20_03250 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BSF20_03255 ENOG4105E0M Sulfatase BSF20_03305 ENOG4105CJ1 ABC, transporter BSF20_03320 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSF20_03325 ENOG4108R1P BSF20_03330 ENOG41061H0 Monooxygenase BSF20_03335 ENOG41082F9 transcriptional regulator BSF20_03340 ENOG4106I4J membrane BSF20_03365 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BSF20_03370 ENOG4105H67 Protein of unknown function (DUF421) BSF20_03380 ENOG4105M18 -acetyltransferase BSF20_03385 ENOG4105WEF catalase BSF20_03400 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BSF20_03410 ENOG4105CDY transcriptional regulatory protein BSF20_03455 ENOG4105CJ1 ABC, transporter BSF20_03465 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BSF20_03470 ENOG4105CBD Diacylglycerol kinase BSF20_03480 ENOG4108IG5 Transcriptional regulator BSF20_03485 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BSF20_03490 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BSF20_03495 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BSF20_03500 ENOG4105CK7 Sodium proline symporter BSF20_03505 ENOG4105KT7 mgtC SapB transporter BSF20_03510 ENOG4105CRN Aminoglycoside phosphotransferase BSF20_03520 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BSF20_03525 ENOG4105C4R Atp-dependent dna helicase BSF20_03540 ENOG4105CBC glutamate synthase BSF20_03545 ENOG4105KGF protein, YerC YecD BSF20_03550 ENOG4108R5T secreted protein BSF20_03565 ENOG4105C12 Phosphoribosylglycinamide synthetase BSF20_03570 ENOG4105DC1 bifunctional purine biosynthesis protein purh BSF20_03575 ENOG4108V3E phosphoribosylglycinamide formyltransferase BSF20_03580 ENOG4105CXB phosphoribosylaminoimidazole synthetase BSF20_03590 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BSF20_03595 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BSF20_03600 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BSF20_03605 ENOG4105C8V SAICAR synthetase BSF20_03610 ENOG4105C83 adenylosuccinate lyase BSF20_03615 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BSF20_03620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BSF20_03640 ENOG4105C7N Xanthine uracil vitamin C permease BSF20_03655 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BSF20_03670 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BSF20_03675 ENOG4105C85 amino acid BSF20_03680 ENOG4107STQ Multicopper oxidase BSF20_03705 ENOG4105JVQ RNA Polymerase BSF20_03710 ENOG4108P49 AntiSigma factor BSF20_03715 ENOG4105EXC Acyl-transferase BSF20_03725 ENOG4108WV1 Pfam:DUF477 BSF20_03730 ENOG4105DQX Zinc finger domain BSF20_03735 ENOG41087YS Phage shock protein A BSF20_03750 ENOG4105CT4 transporter BSF20_03755 ENOG4105CPQ Dehydrogenase BSF20_03760 ENOG4105PGZ NB-ARC domain BSF20_03765 ENOG4105KCT ABC transporter BSF20_03770 ENOG4108M15 ABC transporter BSF20_03815 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BSF20_03820 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BSF20_03825 ENOG4108TYN CAAX amino terminal protease family protein BSF20_03835 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BSF20_03840 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BSF20_03845 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BSF20_03850 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSF20_03855 ENOG4105C5H ABC transporter BSF20_03860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSF20_03865 ENOG410801F ribosomal-protein-alanine acetyltransferase BSF20_03870 ENOG41072GX Peptidase M22 Glycoprotease BSF20_03875 ENOG4105K8N protein family UPF0079, ATPase BSF20_03880 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BSF20_03920 ENOG4107QNK )-transporter BSF20_03940 ENOG4107QTZ amino acid BSF20_03960 ENOG4105DJ2 Major Facilitator Superfamily BSF20_03965 ENOG4105JXH GntR family transcriptional regulator BSF20_03970 ENOG4108TZY GntR Family Transcriptional Regulator BSF20_03975 ENOG4108SUT Major Facilitator Superfamily BSF20_03980 ENOG41090UD (LipO)protein BSF20_03985 ENOG4105FQP Beta-lactamase BSF20_04005 ENOG4105DRR Transcriptional regulator, GntR family BSF20_04015 ENOG4105F2W methyltransferase BSF20_04030 ENOG41090E6 transcriptional regulator MERR family BSF20_04050 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSF20_04055 ENOG4105C2C drug resistance transporter, Bcr CflA BSF20_04065 ENOG4108JYZ YitT family BSF20_04085 ENOG4105EYF MMPL domain protein BSF20_04090 ENOG4108VB1 regulatoR BSF20_04105 ENOG4105PGS Spore coat protein BSF20_04110 ENOG4105E2A Dehydrogenase BSF20_04125 ENOG4108JGH Tetr family transcriptional regulator BSF20_04130 ENOG4105EQ0 Major Facilitator superfamily BSF20_04145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSF20_04155 ENOG4105VUF Transcriptional regulator BSF20_04160 ENOG4105DQ4 alcohol dehydrogenase BSF20_04175 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BSF20_04180 ENOG4105H3G oxidoreductase BSF20_04185 ENOG4105PGM cation diffusion facilitator family transporter BSF20_04195 ENOG4105DNP FAD linked oxidase domain protein BSF20_04210 ENOG41062IR nudix hydrolase BSF20_04215 ENOG4105DXI Major Facilitator superfamily BSF20_04220 ENOG4107U9B transcriptional regulator BSF20_04225 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BSF20_04230 ENOG4108MCI Transcriptional regulator, ARAC family BSF20_04235 ENOG4105CH2 amidohydrolase BSF20_04240 ENOG4105C44 Serine transporter BSF20_04245 ENOG4105KME endoribonuclease L-psp BSF20_04250 ENOG4108WYP Transcriptional regulator BSF20_04255 ENOG4107RCH Diaminopropionate ammonia-lyase BSF20_04265 ENOG4105IRW patatin-like phospholipase family protein BSF20_04285 ENOG41087NI Sulfite exporter TauE/SafE BSF20_04290 ENOG4105VFE sira family BSF20_04295 ENOG4107TPS domain protein BSF20_04300 ENOG4105VFE sira family BSF20_04310 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BSF20_04315 ENOG4105XTG Pfam:DUF156 BSF20_04320 ENOG4105VEQ Cold shock protein BSF20_04325 ENOG4108RYK Nad-dependent epimerase dehydratase BSF20_04330 ENOG4108Z40 Transcriptional regulator BSF20_04335 ENOG4105K56 Transcriptional regulator BSF20_04350 ENOG4105CSH Transporter BSF20_04360 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BSF20_04400 ENOG410906U SprT-like BSF20_04410 ENOG41064BQ Phosphatase BSF20_04420 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BSF20_04425 ENOG4105WN5 stage II sporulation protein BSF20_04430 ENOG4107SGM protein serine threonine phosphatase BSF20_04435 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BSF20_04440 ENOG4105FUA antagonist BSF20_04445 ENOG4107MMM Anti-sigma-factor antagonist BSF20_04450 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BSF20_04460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BSF20_04465 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BSF20_04470 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BSF20_04480 ENOG4105CKV Membrane BSF20_04485 ENOG410905X membrane-flanked domain protein BSF20_04490 ENOG4105C1J atp-dependent rna helicase BSF20_04495 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BSF20_04500 ENOG4105CPF Cell wall formation (By similarity) BSF20_04505 ENOG4105SZ6 Thioredoxin BSF20_04525 ENOG4105FDT acyl-CoA dehydrogenase BSF20_04540 ENOG4105CJ1 ABC, transporter BSF20_04545 ENOG4106F5Q Membrane BSF20_04550 ENOG4107QJT sodium dicarboxylate symporter BSF20_04555 ENOG4108MRH transcriptional regulatory protein BSF20_04560 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BSF20_04565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BSF20_04580 ENOG41082W1 Cupin 2, conserved barrel domain protein BSF20_04585 ENOG4105QVS general stress protein BSF20_04590 ENOG4105EU9 BSF20_04595 ENOG4105KPY Small multidrug resistance protein BSF20_04600 ENOG4105RXJ BSF20_04605 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BSF20_04620 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BSF20_04660 ENOG4105C0X amino acid BSF20_04670 ENOG4107R8N Glycosyl transferase, family 2 BSF20_04675 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BSF20_04690 ENOG4105C9U ATP-dependent DNA helicase RecQ BSF20_04700 ENOG4105VCH membrane BSF20_04710 ENOG410606W general stress protein BSF20_04725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSF20_04735 ENOG4105ETD TRANSCRIPTIONal BSF20_04740 ENOG4107QM2 Aldo Keto reductase BSF20_04745 ENOG4107RVG penicillin-binding protein BSF20_04750 ENOG41061CK Antibiotic biosynthesis monooxygenase BSF20_04760 ENOG4105XJB lipolytic protein G-D-S-L family BSF20_04765 ENOG4107258 Transcriptional regulator BSF20_04775 ENOG4105P4J Allophanate hydrolase, subunit 1 BSF20_04780 ENOG4105CFM UPF0317 protein BSF20_04785 ENOG4105C5A transporter BSF20_04790 ENOG4105E7W lamb ycsf family protein BSF20_04805 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BSF20_04825 ENOG4108ZYE Transcriptional regulator BSF20_04830 ENOG4108T5E Copper resistance protein BSF20_04835 ENOG4105KTB nuclear export factor GLE1 BSF20_04840 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BSF20_04850 ENOG4105C26 Dehydrogenase BSF20_04855 ENOG4108JPW Aminotransferase BSF20_04865 ENOG4105YVS arsR family transcriptional regulator BSF20_04870 ENOG41067V3 Antibiotic biosynthesis monooxygenase BSF20_04875 ENOG4108DBC nitroreductase BSF20_04880 ENOG4105R8C Transcriptional regulator BSF20_04895 ENOG4108IPW abc transporter atp-binding protein BSF20_04900 ENOG4105CM4 permease protein BSF20_04905 ENOG4105DHS permease protein BSF20_04910 ENOG4105CFH Aspartokinase BSF20_04925 ENOG4105BZU Histidine kinase BSF20_04930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSF20_04935 ENOG4107WD8 ABC transporter, permease BSF20_04945 ENOG4108PGP mmge prpd family protein BSF20_04950 ENOG4105CH2 amidohydrolase BSF20_04960 ENOG4108HW4 amino acid AbC transporter BSF20_04965 ENOG4105EAB amino acid AbC transporter BSF20_04970 ENOG4108XSB acetyltransferase, (GNAT) family BSF20_04975 ENOG4105CPU Monooxygenase BSF20_04990 ENOG4105E1K spore germination protein BSF20_05005 ENOG4105DUX Transporter BSF20_05010 ENOG41069ZX BSF20_05015 ENOG41069ZX BSF20_05020 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BSF20_05025 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BSF20_05030 ENOG4106P55 Transcriptional regulator BSF20_05040 ENOG4105DRP amino acid AbC transporter BSF20_05045 ENOG4105CDA abc transporter atp-binding protein BSF20_05060 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BSF20_05080 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_05085 ENOG4105KVH Transcriptional regulator BSF20_05090 ENOG4108VA3 3-hexulose-6-phosphate synthase BSF20_05095 ENOG41080HJ 6-phospho 3-hexuloisomerase BSF20_05110 ENOG4105CS2 ec 3.2.1.21 BSF20_05120 ENOG4105HHM rdd domain containing protein BSF20_05125 ENOG4105E2A Dehydrogenase BSF20_05130 ENOG4105CKI cobalamin synthesis protein BSF20_05135 ENOG4108IFG nitrite reductase, (NAD(P)H) BSF20_05140 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BSF20_05145 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSF20_05150 ENOG4105CAY ferredoxin--nadp reductase BSF20_05155 ENOG4107YHD transcriptional regulator BSF20_05160 ENOG4105CK7 Sodium proline symporter BSF20_05165 ENOG4105C26 Dehydrogenase BSF20_05175 ENOG410756H nucleotidyltransferase BSF20_05180 ENOG4105I82 acetyl xylan esterase BSF20_05185 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BSF20_05190 ENOG4105DJB Major Facilitator Superfamily BSF20_05200 ENOG4105I1F Resistance protein BSF20_05210 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BSF20_05215 ENOG4105EIG urea carboxylase-associated protein 1 BSF20_05245 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BSF20_05255 ENOG4105DQ6 Transposase BSF20_05285 ENOG4107SQ8 Glycine betaine BSF20_05290 ENOG4108IJ7 Glycine betaine BSF20_05295 ENOG41079KZ Major Facilitator Superfamily BSF20_05305 ENOG4108TTB tellurium resistance protein BSF20_05310 ENOG4107TS3 membrane protein, TerC BSF20_05315 ENOG4106FN3 tellurium resistance protein BSF20_05320 ENOG4106FN3 tellurium resistance protein BSF20_05325 ENOG4108N0M stress protein BSF20_05330 ENOG4105DEN Luciferase family BSF20_05340 ENOG4105DIK (ABC) transporter BSF20_05345 ENOG4105DSE periplasmic solute binding protein BSF20_05355 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BSF20_05385 ENOG4107SET aldo keto reductase BSF20_05390 ENOG41060AI SEC-C motif BSF20_05395 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BSF20_05400 ENOG4107RB3 L-asparaginase BSF20_05405 ENOG4105J7D transcriptional regulator BSF20_05410 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSF20_05415 ENOG4107EPV Aminotransferase class V BSF20_05420 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BSF20_05425 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BSF20_05430 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BSF20_05435 ENOG4105DGI Alkaline phosphatase BSF20_05450 ENOG4105XXY Thioredoxin BSF20_05455 ENOG4108VGI doxx family BSF20_05460 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BSF20_05465 ENOG4108TVJ Nitroreductase BSF20_05470 ENOG41076HS cation diffusion facilitator family transporter BSF20_05495 ENOG4105CSV Glutaminase BSF20_05505 ENOG4108J5H Homocysteine s-methyltransferase BSF20_05510 ENOG4108IQI permease BSF20_05515 ENOG4105CM2 brancheD-chain amino acid aminotransferase BSF20_05525 ENOG4105C72 UPF0176 protein BSF20_05540 ENOG4107ZTW SNARE associated Golgi BSF20_05545 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BSF20_05550 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BSF20_05555 ENOG4107SCQ Iron-containing alcohol dehydrogenase BSF20_05590 ENOG4105CXY transporter BSF20_05595 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BSF20_05600 ENOG4107QTZ amino acid BSF20_05615 ENOG4106DDH Sporulation-specific SASP protein BSF20_05640 ENOG4105CJ1 ABC, transporter BSF20_05645 ENOG4105WH1 Two component transcriptional regulator luxr family BSF20_05650 ENOG4105BZU Histidine kinase BSF20_05665 ENOG41061AU MarR family Transcriptional regulator BSF20_05675 ENOG41067MG lrgb family BSF20_05685 ENOG4106K80 BSF20_05710 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BSF20_05715 ENOG4107U5W ybbr family BSF20_05720 ENOG4105C8B TIGR00159 family BSF20_05730 ENOG4105EMN RNA polymerase sigma factor BSF20_05760 ENOG4105EWC Purine nucleoside phosphorylase BSF20_05770 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BSF20_05785 ENOG4105D17 glycoside hydrolase, family 3 domain protein BSF20_05790 ENOG4105EHZ conserved protein UCP016719 BSF20_05795 ENOG410874W AraC family transcriptional regulator BSF20_05815 ENOG4108SA1 esterase BSF20_05825 ENOG4105CHH sulfate transporter BSF20_05830 ENOG4105CPQ Dehydrogenase BSF20_05840 ENOG4108JPW Aminotransferase BSF20_05905 ENOG4108NMV polysaccharide deacetylase BSF20_05920 ENOG4105D1F ATP-binding protein BSF20_05940 ENOG4108I0C methyltransferase BSF20_05945 ENOG4108UJD 30S ribosomal protein S9 BSF20_05950 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BSF20_05955 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BSF20_05960 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BSF20_05965 ENOG4108JJB ABC transporter BSF20_05970 ENOG4108JJB ABC transporter BSF20_05975 ENOG4108ZT0 50S ribosomal protein l17 BSF20_05980 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSF20_05985 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BSF20_05990 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BSF20_06000 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BSF20_06005 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BSF20_06010 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BSF20_06015 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BSF20_06020 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BSF20_06025 ENOG4105VPB 50S ribosomal protein L30 BSF20_06030 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BSF20_06035 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BSF20_06040 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BSF20_06045 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BSF20_06050 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BSF20_06060 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BSF20_06065 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BSF20_06070 ENOG41082SA 50s ribosomal protein l29 BSF20_06075 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BSF20_06080 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BSF20_06085 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BSF20_06090 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BSF20_06095 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BSF20_06100 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BSF20_06105 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BSF20_06110 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BSF20_06115 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BSF20_06120 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BSF20_06125 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BSF20_06130 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BSF20_06135 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BSF20_06140 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BSF20_06145 ENOG4105XPM ribosomal protein BSF20_06150 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSF20_06155 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSF20_06160 ENOG4107Y49 methyltransferase BSF20_06165 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BSF20_06170 ENOG4108VZM 50s ribosomal protein L10 BSF20_06180 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BSF20_06185 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BSF20_06205 ENOG4105M0M Tetracycline resistance protein BSF20_06210 ENOG4105C2N RNA methyltransferase TrmH family group 3 BSF20_06215 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BSF20_06225 ENOG4105D7W serine acetyltransferase BSF20_06230 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BSF20_06235 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BSF20_06240 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BSF20_06245 ENOG4105CTP PilT protein domain protein BSF20_06250 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BSF20_06255 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BSF20_06265 ENOG41066A3 ATP guanido phosphotransferase BSF20_06270 ENOG4108Z0C Uvrb UvrC protein BSF20_06355 ENOG4105CRK lysyL-tRNA synthetase BSF20_06360 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BSF20_06370 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BSF20_06375 ENOG4105KRF dihydroneopterin aldolase BSF20_06380 ENOG4105EEI dihydropteroate synthase BSF20_06385 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BSF20_06390 ENOG4105DDQ anthranilate synthase BSF20_06395 ENOG4105CRQ synthase (Component I) BSF20_06400 ENOG4105C6T cysteine synthase BSF20_06405 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BSF20_06410 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BSF20_06415 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BSF20_06420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BSF20_06425 ENOG4108UGV hypoxanthine phosphoribosyltransferase BSF20_06430 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BSF20_06460 ENOG41060GV RNA binding s1 domain protein BSF20_06475 ENOG4105VYY sporulation protein yabp BSF20_06480 ENOG41082I2 s4 domain protein BSF20_06485 ENOG4108IY2 MazG family BSF20_06495 ENOG4108M14 stage v sporulation protein t BSF20_06500 ENOG4108JA2 transcriptioN-repair coupling factor BSF20_06515 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BSF20_06520 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BSF20_06525 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BSF20_06530 ENOG4105K4W Could be involved in septation (By similarity) BSF20_06535 ENOG4105KME endoribonuclease L-psp BSF20_06540 ENOG4105DFT pur operon repressor BSF20_06545 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BSF20_06550 ENOG4105XEW small acid-soluble spore protein BSF20_06555 ENOG4105W42 Veg protein BSF20_06560 ENOG4105XFA sporulation peptidase YabG BSF20_06565 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BSF20_06575 ENOG41069ER domain protein BSF20_06580 ENOG4105F8V Hydrolase, tatD family BSF20_06585 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BSF20_06590 ENOG4105KRN Transcriptional regulator, abrb family BSF20_06595 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BSF20_06600 ENOG4105VC4 domain protein BSF20_06605 ENOG41060K3 Methyltransferase BSF20_06615 ENOG4105MA4 psp1 domain protein BSF20_06620 ENOG4105FA2 dna polymerase iii BSF20_06625 ENOG4105XVJ Protein of unknown function (DUF327) BSF20_06630 ENOG4105X0R protein from nitrogen regulatory protein P-II BSF20_06635 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BSF20_06640 ENOG4105CXN decarboxylase BSF20_06645 ENOG4105CDW Resistance protein BSF20_06685 ENOG41067KS pro-sigma K processing BSF20_06695 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BSF20_06700 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BSF20_06705 ENOG4105C6E dna polymerase iii BSF20_06715 ENOG4108Z6B deaminase BSF20_06720 ENOG4105GTG Isochorismatase BSF20_06725 ENOG4105VRS hydrolase family 18 BSF20_06735 ENOG4105ZMH deoxynucleoside kinase BSF20_06745 ENOG4105BZW Glycerate kinase BSF20_06750 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BSF20_06755 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BSF20_06760 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BSF20_06770 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BSF20_06805 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSF20_06810 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSF20_06820 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BSF20_06825 ENOG410848D S4 domain protein YaaA BSF20_06830 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BSF20_06835 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BSF20_06840 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BSF20_06855 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BSF20_06860 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BSF20_06875 ENOG4107QJE Chromosome Partitioning Protein BSF20_06880 ENOG4105FA0 parb-like partition protein BSF20_06885 ENOG4108ZDA Sporulation protein YyaC BSF20_06900 ENOG4105VDK protein, conserved in bacteria BSF20_06905 ENOG4108J2R molybdopterin oxidoreductase BSF20_06910 ENOG4105C3G gtp-binding protein BSF20_06915 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BSF20_06920 ENOG4108UUM single-stranded DNA-binding protein BSF20_06925 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BSF20_06935 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BSF20_06940 ENOG4105CGK Exodeoxyribonuclease III BSF20_06950 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BSF20_06960 ENOG4107FCW Abortive infection protein BSF20_06965 ENOG4105C7Z Conserved Protein BSF20_06975 ENOG410847I Transcriptional regulator, BadM Rrf2 family BSF20_06985 ENOG4107Y9U Membrane BSF20_06995 ENOG4105DTD Dehydrogenase BSF20_07000 ENOG4105CMU LysR family (Transcriptional regulator BSF20_07005 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BSF20_07020 ENOG4108U05 Transcriptional regulator BSF20_07030 ENOG4105FS7 Transcriptional regulator BSF20_07035 ENOG4108TVJ Nitroreductase BSF20_07055 ENOG4107XBN GntR Family Transcriptional Regulator BSF20_07060 ENOG4108HKT sucrose-6-phosphate hydrolase BSF20_07065 ENOG4105EDQ levansucrase EC 2.4.1.10 BSF20_07070 ENOG4108UZ3 Transporter BSF20_07075 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BSF20_07080 ENOG4105KVH Transcriptional regulator BSF20_07090 ENOG4108XMW Membrane BSF20_07095 ENOG4105BZR domain protein BSF20_07115 ENOG4105CPK Glycosyl transferase (Group 1 BSF20_07120 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BSF20_07130 ENOG4107QPH glycogen) synthase BSF20_07155 ENOG4105CDU Replicative dna helicase BSF20_07160 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BSF20_07165 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BSF20_07195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSF20_07200 ENOG4105BZU Histidine kinase BSF20_07215 ENOG4105Q2H domain protein BSF20_07220 ENOG4105C0H protease BSF20_07230 ENOG4105BZU Histidine kinase BSF20_07235 ENOG4105D06 uba thif-type nad fad binding protein BSF20_07250 ENOG4105C5H ABC transporter BSF20_07260 ENOG4108JUB Transcriptional regulator BSF20_07265 ENOG41082BM Transcriptional regulator, arsr family BSF20_07275 ENOG4105C8Y Acetylornithine aminotransferase BSF20_07280 ENOG4108IQI permease BSF20_07285 ENOG41066UZ arginase EC 3.5.3.1 BSF20_07295 ENOG4105WQG acetyltransferase BSF20_07300 ENOG4105CPC Aldo Keto reductase BSF20_07305 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BSF20_07325 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BSF20_07335 ENOG4105ESI atpase involved in dna repair BSF20_07345 ENOG4105XRQ Xanthine dehydrogenase accessory factor BSF20_07365 ENOG4108XHQ (2Fe-2S)-binding domain protein BSF20_07370 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BSF20_07375 ENOG4105C85 amino acid BSF20_07380 ENOG4108JU3 Alkyl hydroperoxide reductase BSF20_07385 ENOG4105D3R alkyl hydroperoxide reductase BSF20_07390 ENOG4106H3A restriction BSF20_07395 ENOG4105D0M Protease HtpX homolog BSF20_07400 ENOG4107QKA exodeoxyribonuclease V beta BSF20_07410 ENOG41085PJ rdd domain containing protein BSF20_07415 ENOG4105F27 Major Facilitator BSF20_07420 ENOG4105WAB arsR family transcriptional regulator BSF20_07430 ENOG4108ITS PQQ enzyme repeat BSF20_07435 ENOG4105C26 Dehydrogenase BSF20_07440 ENOG4105ST3 Transcriptional regulator BSF20_07445 ENOG4105ECK Fatty Acid Desaturase BSF20_07450 ENOG4108ZGX Histidine kinase BSF20_07455 ENOG4108S01 response regulator BSF20_07460 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BSF20_07470 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BSF20_07475 ENOG4107QNK )-transporter BSF20_07480 ENOG4105CPC Aldo Keto reductase BSF20_07490 ENOG4105C26 Dehydrogenase BSF20_07500 ENOG4105EDK PfkB domain protein BSF20_07510 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BSF20_07520 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BSF20_07525 ENOG4105F0H myo-inositol catabolism protein BSF20_07530 ENOG4105WZ4 isomerase BSF20_07565 ENOG4108V5C ABC transporter BSF20_07595 ENOG410667J hydrolase BSF20_07600 ENOG4107RHR regulatoR BSF20_07605 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BSF20_07610 ENOG4105D9N nucleoside BSF20_07615 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BSF20_07625 ENOG4107W25 arginase agmatinase formiminoglutamase BSF20_07630 ENOG4105CI2 imidazolone-5-propionate hydrolase BSF20_07635 ENOG4105CGP Urocanate hydratase BSF20_07640 ENOG4105C84 Histidine ammonia-lyase BSF20_07650 ENOG4106Z5D Glycoside Hydrolase Family 43 BSF20_07700 ENOG4107YZX Universal stress protein BSF20_07710 ENOG4108NR7 pectate lyase BSF20_07795 ENOG4105C1J atp-dependent rna helicase BSF20_07800 ENOG4105DEU major facilitator superfamily BSF20_07815 ENOG4105D4T Citrate transporter BSF20_07820 ENOG4105CH6 catalase BSF20_07840 ENOG4105DHI Methyltransferase BSF20_07855 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSF20_07860 ENOG4105CMR udp-glucose 4-epimerase BSF20_07870 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BSF20_07885 ENOG4107BJW polysaccharide deacetylase BSF20_07890 ENOG4105D2K citrate carrier protein BSF20_07895 ENOG4105C4M (Ubiquinol oxidase) subunit I BSF20_07900 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BSF20_07905 ENOG4108JJ9 ABC, transporter BSF20_07910 ENOG4108JJ8 (ABC) transporter BSF20_07915 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BSF20_07920 ENOG4105ETS cytosine purines uracil thiamine allantoin BSF20_07925 ENOG4107QHE Choloylglycine hydrolase BSF20_07930 ENOG4105CH6 catalase BSF20_07940 ENOG4105DG6 mannose-6-phosphate isomerase BSF20_07945 ENOG4105EVU fructokinase BSF20_07950 ENOG4105CS2 ec 3.2.1.21 BSF20_07955 ENOG4105CK1 PTS System BSF20_07960 ENOG4105VCP PTS System BSF20_07965 ENOG4105VZJ PTS System BSF20_07970 ENOG4107R5R arsenical pump membrane protein BSF20_07975 ENOG41082YX Transcriptional regulator, arsr family BSF20_07985 ENOG4105EHG Permease protein BSF20_07990 ENOG4105DQ5 transport system permease protein BSF20_08000 ENOG4105EMD TRANSCRIPTIONal BSF20_08005 ENOG4105VZJ PTS System BSF20_08010 ENOG4105CK1 PTS System BSF20_08015 ENOG4105VCP PTS System BSF20_08020 ENOG4105F8D glycoside hydrolase family 4 BSF20_08025 ENOG4105CM2 brancheD-chain amino acid aminotransferase BSF20_08030 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BSF20_08035 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BSF20_08040 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BSF20_08045 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BSF20_08055 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BSF20_08065 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BSF20_08070 ENOG4105GVJ transcriptional regulator BSF20_08075 ENOG4105X1N Glycosyl transferase family 8 BSF20_08080 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BSF20_08085 ENOG4105CK1 PTS System BSF20_08095 ENOG4105DR4 Methyltransferase BSF20_08100 ENOG4107TXC Transcriptional regulator BSF20_08110 ENOG41067MG lrgb family BSF20_08115 ENOG4105VAW lrga family BSF20_08120 ENOG4105CMU LysR family (Transcriptional regulator BSF20_08125 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BSF20_08130 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BSF20_08140 ENOG410650H (LipO)protein BSF20_08145 ENOG4105DBE peroxidase BSF20_08150 ENOG4107ZXU DSBA oxidoreductase BSF20_08175 ENOG4105WH5 Teichoic acid glycosylation protein BSF20_08190 ENOG4107BMA Transglycosylase associated protein BSF20_08195 ENOG4105E2S oxidase) subunit II BSF20_08200 ENOG4105BZ9 Cytochrome C oxidase, subunit I BSF20_08220 ENOG4105I4A GCN5-related N-acetyltransferase BSF20_08230 ENOG4108DBC nitroreductase BSF20_08235 ENOG4105DEN Luciferase family BSF20_08240 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BSF20_08255 ENOG4105C5Y PTS System BSF20_08270 ENOG4105DWF phosphomethylpyrimidine kinase BSF20_08290 ENOG4108RJ9 Glycosyl transferase, family 2 BSF20_08295 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BSF20_08330 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSF20_08335 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BSF20_08345 ENOG4107TY6 Acylneuraminate cytidylyltransferase BSF20_08350 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BSF20_08355 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BSF20_08360 ENOG4105C1B dTDP-glucose 4-6-dehydratase BSF20_08365 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BSF20_08370 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BSF20_08380 ENOG4105D82 Glutamate dehydrogenase BSF20_08385 ENOG4105C26 Dehydrogenase BSF20_08400 ENOG4105C2C drug resistance transporter, Bcr CflA BSF20_08405 ENOG4105FCW Major Facilitator superfamily BSF20_08435 ENOG4105CHM Aminotransferase BSF20_08445 ENOG4107JTW chlorite dismutase BSF20_08450 ENOG4108IJ2 phosphate acetyltransferase BSF20_08455 ENOG4105HMI Membrane BSF20_08460 ENOG4105DUM transcriptional regulator, lysR family BSF20_08465 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BSF20_08475 ENOG4105K7K Transcriptional regulator BSF20_08480 ENOG4108VCI transcription factor, rsfa family BSF20_08490 ENOG4105DCI Phosphohydrolase BSF20_08500 ENOG4105CUB amino acid BSF20_08510 ENOG41067TZ transcriptional regulator, MarR family BSF20_08515 ENOG41069HH 4-oxalocrotonate tautomerase BSF20_08520 ENOG4108Z4T Peptidase M50 BSF20_08525 ENOG4108XFG YwhD family BSF20_08535 ENOG4105BZ4 penicillin-binding protein BSF20_08540 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BSF20_08545 ENOG4105CYW agmatinase BSF20_08585 ENOG4107JM4 Tetratricopeptide repeat BSF20_08590 ENOG410684U Domain of unknown function (DUF1934) BSF20_08595 ENOG4105C75 arginyL-tRNA synthetase BSF20_08605 ENOG4107V6Q Cyclic nucleotide-binding domain BSF20_08625 ENOG4108IUE nitrate reductase beta subunit BSF20_08630 ENOG4105R3A Nitrate reductase BSF20_08645 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BSF20_08650 ENOG4105BZ1 (ABC) transporter BSF20_08660 ENOG4105E5J UV damage endonuclease BSF20_08670 ENOG4105DF6 Fe-S oxidoreductase BSF20_08680 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BSF20_08690 ENOG410812K response regulator receiver protein BSF20_08695 ENOG4105D2N Aldolase BSF20_08705 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BSF20_08710 ENOG4105CBT Fructose-1,6-bisphosphatase BSF20_08715 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BSF20_08720 ENOG41082DI 50s ribosomal protein l31 BSF20_08725 ENOG4107104 thymidine kinase BSF20_08730 ENOG4105C6K Malic enzyme BSF20_08735 ENOG4107TT2 Auxin Efflux Carrier BSF20_08745 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BSF20_08750 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BSF20_08755 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BSF20_08770 ENOG4108ZXQ stage ii sporulation protein r BSF20_08780 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSF20_08785 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BSF20_08790 ENOG4107WAU Protein tyrosine phosphatase BSF20_08795 ENOG4108YZG isomerase BSF20_08800 ENOG4108UIC UPF0340 protein BSF20_08805 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BSF20_08810 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BSF20_08820 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BSF20_08835 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BSF20_08840 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BSF20_08845 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BSF20_08850 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BSF20_08855 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BSF20_08865 ENOG4106778 Protein of unknown function (DUF1146) BSF20_08875 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BSF20_08890 ENOG4108TF4 von Willebrand factor, type A BSF20_08895 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BSF20_08900 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSF20_08920 ENOG4108YZ9 Urea amidohydrolase subunit gamma BSF20_08925 ENOG4105KI2 Urea amidohydrolase subunit beta BSF20_08930 ENOG4105CQM Urea amidohydrolase subunit alpha BSF20_08935 ENOG4108Z40 Transcriptional regulator BSF20_08945 ENOG4107T94 Endo-14-beta-xylanase BSF20_08950 ENOG4106BRK BSF20_08955 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BSF20_08970 ENOG4107TCE N-acetyltransferase BSF20_08975 ENOG4105FRN stage II sporulation protein BSF20_08985 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BSF20_08990 ENOG4105CNI cell division protein FtsW BSF20_09000 ENOG4105BZU Histidine kinase BSF20_09005 ENOG4105D3W isochorismatase BSF20_09010 ENOG41080V3 Major Facilitator superfamily BSF20_09015 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BSF20_09020 ENOG4105CZM Major Facilitator BSF20_09025 ENOG4107MII Sugar-specific transcriptional regulator TrmB BSF20_09030 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BSF20_09035 ENOG4105DFF Rod shape-determining protein mreb BSF20_09045 ENOG4105CGA flagellar basal-body rod protein FlgG BSF20_09055 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BSF20_09060 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BSF20_09075 ENOG4105Z8H single-stranded DNA-binding protein BSF20_09080 ENOG4105E98 transcriptional regulator DeoR family BSF20_09085 ENOG410667J hydrolase BSF20_09090 ENOG4105C0D helicase BSF20_09095 ENOG4105KBK Zinc finger, swim domain protein BSF20_09105 ENOG4105HTX biosynthesis protein BSF20_09110 ENOG4107YJ4 chain length determinant protein BSF20_09115 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BSF20_09120 ENOG4105C6Y Udp-glucose 6-dehydrogenase BSF20_09125 ENOG4108XI2 Domain of unknown function (DUF1963) BSF20_09170 ENOG4107V2S Transcriptional regulator BSF20_09175 ENOG4108WS4 fmn reductase BSF20_09185 ENOG4105FGV Chromate BSF20_09190 ENOG4105CAH Chromate BSF20_09200 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BSF20_09210 ENOG4107XC4 flavin reductase domain protein, FMN-binding BSF20_09225 ENOG4106UIA BSF20_09240 ENOG4107RSM transcriptional regulator BSF20_09250 ENOG4107FQX Alpha-acetolactate decarboxylase BSF20_09255 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BSF20_09265 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BSF20_09270 ENOG4105CNN ABC, transporter BSF20_09275 ENOG4105C2J ABC transporter BSF20_09280 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BSF20_09285 ENOG4108RVA ribokinase BSF20_09290 ENOG4105ETE Transcriptional regulator (LacI family BSF20_09305 ENOG4105E1K spore germination protein BSF20_09310 ENOG4105N98 Capsule biosynthesis protein capB BSF20_09320 ENOG4105PNM synthesis protein BSF20_09325 ENOG4105K4H Nlp p60 protein BSF20_09330 ENOG4106UBQ BSF20_09335 ENOG4105J7I hydrolase BSF20_09340 ENOG4108KGH TRANSCRIPTIONal BSF20_09345 ENOG4105C54 Major Facilitator superfamily BSF20_09350 ENOG4107R8N Glycosyl transferase, family 2 BSF20_09355 ENOG4108NHD germination protein BSF20_09370 ENOG4105DG6 mannose-6-phosphate isomerase BSF20_09380 ENOG4107RZX Teichoic acid biosynthesis protein BSF20_09390 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BSF20_09400 ENOG4107SJB teichoic acid biosynthesis BSF20_09410 ENOG4105EY8 ABC transporter BSF20_09415 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BSF20_09420 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BSF20_09435 ENOG4105JFG SpoIID LytB domain protein BSF20_09440 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSF20_09445 ENOG4105D3Q Sugar transferase BSF20_09450 ENOG4105PSV Polysaccharide Biosynthesis Protein BSF20_09455 ENOG4107RA4 Glycosyl transferase (Group 1 BSF20_09460 ENOG4105C6Y Udp-glucose 6-dehydrogenase BSF20_09465 ENOG4105QZI O-Antigen Polymerase BSF20_09480 ENOG4107EF8 Glycosyl transferase (Group 1 BSF20_09485 ENOG4105ESV Glycosyl transferase, family 4 BSF20_09490 ENOG4108KGH TRANSCRIPTIONal BSF20_09495 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BSF20_09500 ENOG4105BZU Histidine kinase BSF20_09505 ENOG4105WH1 Two component transcriptional regulator luxr family BSF20_09525 ENOG41081UC Inherit from COG: Competence protein BSF20_09530 ENOG4105RU3 BSF20_09545 ENOG4105E1Q flagellar hook-associated protein BSF20_09550 ENOG4105DTJ flagellar hook-associated protein BSF20_09560 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BSF20_09565 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BSF20_09570 ENOG4105I03 Flagellin BSF20_09575 ENOG4107RT6 flagellar hook-associated BSF20_09580 ENOG4105MQ3 flagellar protein FliS BSF20_09595 ENOG4105MS2 ribosomal subunit Interface protein BSF20_09600 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BSF20_09605 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BSF20_09620 ENOG4105CAK Cell division ATP-binding protein ftsE BSF20_09625 ENOG4105CRP Part of the ABC transporter FtsEX involved in BSF20_09630 ENOG4108M26 parallel beta-helix repeat protein BSF20_09635 ENOG4105CN1 protease BSF20_09660 ENOG4105MKU Transcriptional regulator BSF20_09675 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BSF20_09680 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BSF20_09695 ENOG4108PY7 BSF20_09700 ENOG41067S9 phage shock protein C, PspC BSF20_09705 ENOG41086DT Membrane protein of unknown function BSF20_09710 ENOG41088CQ domain protein BSF20_09715 ENOG4105J7D transcriptional regulator BSF20_09720 ENOG4105FDP GntR family transcriptional regulator BSF20_09725 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BSF20_09730 ENOG4105CE4 GlcNAc 6-P deacetylase BSF20_09735 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BSF20_09745 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BSF20_09750 ENOG4108S4C acetyltransferase BSF20_09760 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BSF20_09765 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BSF20_09770 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BSF20_09775 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BSF20_09780 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BSF20_09785 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BSF20_09790 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BSF20_09795 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BSF20_09800 ENOG4105BZ1 (ABC) transporter BSF20_09805 ENOG4105GIG BSF20_09810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSF20_09815 ENOG4105BZU Histidine kinase BSF20_09830 ENOG4105C3M thioredoxin reductase BSF20_09835 ENOG4108Z4K mutator MutT protein BSF20_09840 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BSF20_09845 ENOG4105CHW UPF0052 protein BSF20_09850 ENOG4105CIE May be required for sporulation (By similarity) BSF20_09855 ENOG4105KRI phosphocarrier protein (HPr BSF20_09860 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BSF20_09865 ENOG4105GGE ribonuclease BSF20_09870 ENOG4105C5I Dehydrogenase BSF20_09880 ENOG4108V2W Carbonate dehydratase BSF20_09885 ENOG4105CHH sulfate transporter BSF20_09890 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BSF20_09895 ENOG4108URH decarboxylase BSF20_09905 ENOG4105C7F AcnD-accessory protein PrpF BSF20_09910 ENOG4108KAM Transcriptional regulator BSF20_09915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BSF20_09920 ENOG4105ETE Transcriptional regulator (LacI family BSF20_09925 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BSF20_09930 ENOG4108HKT sucrose-6-phosphate hydrolase BSF20_09960 ENOG4105PY6 Phenolic acid decarboxylase BSF20_09965 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BSF20_09975 ENOG4105NAE bifunctional deaminase-reductase domain protein BSF20_09985 ENOG4105EBR Carboxylesterase BSF20_09995 ENOG4105HTX biosynthesis protein BSF20_10000 ENOG4108QV3 biosynthesis protein BSF20_10010 ENOG4108PQP glycosyl transferase group 1 BSF20_10015 ENOG4105K64 Glycosyl transferase, family 2 BSF20_10020 ENOG4108KMV Glycosyl transferase (Group 1 BSF20_10025 ENOG41068W6 Capsular polysaccharide biosynthesis protein BSF20_10030 ENOG4107QRS glycosyltransferase group 2 family protein BSF20_10040 ENOG4105K64 Glycosyl transferase, family 2 BSF20_10050 ENOG4105D3Q Sugar transferase BSF20_10055 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BSF20_10060 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSF20_10065 ENOG4108ZPC Polysaccharide pyruvyl transferase BSF20_10075 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_10080 ENOG4105DAA L-lactate BSF20_10085 ENOG4105JXH GntR family transcriptional regulator BSF20_10090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSF20_10095 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BSF20_10100 ENOG4107QR9 Iron-sulfur cluster binding protein BSF20_10110 ENOG4105C6Z Gluconate BSF20_10115 ENOG4105CMG Carbohydrate kinase BSF20_10120 ENOG4106KNT transcriptional regulator BSF20_10130 ENOG4107RT3 EamA-like transporter family BSF20_10135 ENOG4105GZI Transcriptional regulator BSF20_10145 ENOG4105DEN Luciferase family BSF20_10150 ENOG4105CMD Transcriptional regulator, GntR family BSF20_10165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSF20_10175 ENOG4105BZA Phosphoglycerate kinase BSF20_10180 ENOG4105CP7 Triose-phosphate isomerase BSF20_10185 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BSF20_10190 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BSF20_10195 ENOG4105IIU Aminopeptidase BSF20_10200 ENOG4107QQG Dehydrogenase BSF20_10205 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSF20_10210 ENOG4108IAJ Nad-dependent epimerase dehydratase BSF20_10215 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSF20_10230 ENOG4105FJR Lmbe family BSF20_10245 ENOG4108W0I acetyltransferase BSF20_10250 ENOG4105T65 Membrane-associated protein BSF20_10265 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BSF20_10270 ENOG4107HG4 Transcriptional regulator BSF20_10275 ENOG4108IJ8 ABC transporter BSF20_10280 ENOG4105E90 ABC transporter BSF20_10285 ENOG4108HQR Glycine betaine BSF20_10290 ENOG4105R40 Glycine betaine carnitine choline BSF20_10295 ENOG4107HG4 Transcriptional regulator BSF20_10300 ENOG4108IJ8 ABC transporter BSF20_10305 ENOG4105E90 ABC transporter BSF20_10310 ENOG4108HQR Glycine betaine BSF20_10315 ENOG4105R40 Glycine betaine carnitine choline BSF20_10320 ENOG4105DA5 (ABC) transporter BSF20_10345 ENOG4105KVH Transcriptional regulator BSF20_10365 ENOG4105XZU Preprotein translocase, subunit SecG BSF20_10375 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BSF20_10380 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BSF20_10390 ENOG41067XF inhibitor BSF20_10395 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BSF20_10400 ENOG4108KSA LysR family transcriptional regulator BSF20_10405 ENOG4108XSB acetyltransferase, (GNAT) family BSF20_10430 ENOG4105CDA abc transporter atp-binding protein BSF20_10435 ENOG4105DEN Luciferase family BSF20_10470 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BSF20_10475 ENOG4105D9R oxidoreductase BSF20_10480 ENOG4105VPX protein, conserved in bacteria BSF20_10485 ENOG410681U heavy metal transport detoxification protein BSF20_10490 ENOG4105C59 p-type ATPase BSF20_10495 ENOG4105C59 p-type ATPase BSF20_10500 ENOG4107ZQN disulfide bond BSF20_10515 ENOG4105EN6 Membrane BSF20_10520 ENOG4105EEM helicase BSF20_10525 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSF20_10530 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BSF20_10540 ENOG4105EEQ Na H antiporter BSF20_10555 ENOG4108KYE ABC-2 type transporter BSF20_10565 ENOG4105CJ1 ABC, transporter BSF20_10570 ENOG4105BZU Histidine kinase BSF20_10575 ENOG4105WH1 Two component transcriptional regulator luxr family BSF20_10580 ENOG4105E0C molybdate abc transporter BSF20_10585 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BSF20_10590 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BSF20_10595 ENOG4107QZ2 Sulfatase BSF20_10600 ENOG4107K5X Membrane-bound metal-dependent hydrolase BSF20_10610 ENOG4105D5Q Arginine ornithine antiporter BSF20_10615 ENOG4105JQZ Methyltransferase BSF20_10625 ENOG4105DQ5 transport system permease protein BSF20_10630 ENOG4105EHG Permease protein BSF20_10635 ENOG4105E0A ABC, transporter BSF20_10645 ENOG4105F0F Oxalate decarboxylase BSF20_10655 ENOG4106DF4 Sigma-70, region 4 BSF20_10665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSF20_10675 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BSF20_10680 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BSF20_10685 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BSF20_10690 ENOG4105EHG Permease protein BSF20_10695 ENOG4105E0A ABC, transporter BSF20_10700 ENOG4108WBT adenosyltransferase BSF20_10715 ENOG41087YS Phage shock protein A BSF20_10730 ENOG4105ENE Histidine kinase BSF20_10735 ENOG4105WH1 Two component transcriptional regulator luxr family BSF20_10760 ENOG4105C9Q fumarate hydratase class II BSF20_10765 ENOG41067SE Tetr family transcriptional regulator BSF20_10770 ENOG4105F3H Histidine kinase BSF20_10780 ENOG4105C0H protease BSF20_10785 ENOG4105HUF DNA protection during starvation protein BSF20_10790 ENOG4105E1F short-chain dehydrogenase reductase BSF20_10805 ENOG4105E0A ABC, transporter BSF20_10825 ENOG4105C5Q Transcriptional regulator BSF20_10830 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSF20_10835 ENOG41067TZ transcriptional regulator, MarR family BSF20_10860 ENOG4105CHU acetyl-coa acetyltransferase BSF20_10865 ENOG4105C1G acyl-Coa dehydrogenase BSF20_10870 ENOG41080E8 Transcriptional regulator, Spx MgsR family BSF20_10875 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BSF20_10900 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BSF20_10905 ENOG4108UMI ABC transporter, permease BSF20_10910 ENOG4105D01 (LipO)protein BSF20_10920 ENOG4105C3K feS assembly ATPase SufC BSF20_10925 ENOG4105JRK feS assembly protein SufD BSF20_10930 ENOG4105C9B Cysteine desulfurase BSF20_10935 ENOG4108UNV SUF system FeS assembly protein, NifU family BSF20_10940 ENOG4105DIW FeS assembly protein SUFB BSF20_10945 ENOG41083Q9 chitosanase BSF20_10955 ENOG4107VFR oxidoreductase BSF20_10960 ENOG4105PKS Excinuclease abc c subunit domain protein BSF20_10975 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BSF20_10980 ENOG4105XN3 extracellular solute-binding protein family 1 BSF20_10985 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BSF20_10990 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BSF20_10995 ENOG4108KPW sugar kinase BSF20_11000 ENOG4105FDP GntR family transcriptional regulator BSF20_11005 ENOG4108IJ9 (ABC) transporter BSF20_11010 ENOG4108K8S endonuclease I BSF20_11020 ENOG4105C5R Aminotransferase BSF20_11050 ENOG4105G9B Transcriptional regulator BSF20_11055 ENOG4105CD3 dihydroorotase BSF20_11065 ENOG4105I3N Conserved Protein BSF20_11075 ENOG4107R8B 5'-nucleotidase BSF20_11080 ENOG4108YTE sporulation protein YunB BSF20_11085 ENOG4105FAA peptidase M23 BSF20_11090 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BSF20_11095 ENOG4105MMD transcriptional regulator BSF20_11105 ENOG4105D4U had-superfamily hydrolase, subfamily iia BSF20_11110 ENOG4108W5N phosphatidylglycerophosphatase a BSF20_11120 ENOG4105D6E homoserine dehydrogenase BSF20_11125 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BSF20_11130 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BSF20_11135 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BSF20_11140 ENOG41083MR nifu domain-containing protein BSF20_11155 ENOG4105ZKE UPF0349 protein BSF20_11165 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BSF20_11170 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BSF20_11175 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BSF20_11200 ENOG4105CJ1 ABC, transporter BSF20_11215 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BSF20_11230 ENOG4105CEP NADH dehydrogenase BSF20_11240 ENOG41069ER domain protein BSF20_11250 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BSF20_11270 ENOG4105NIV Esterase BSF20_11275 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BSF20_11280 ENOG4105E4F Isochorismate synthase BSF20_11285 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BSF20_11290 ENOG4105WQI isochorismatase BSF20_11295 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_11300 ENOG4105WQT MbtH domain protein BSF20_11310 ENOG4105DCF alanine dehydrogenase BSF20_11315 ENOG4108K8K Transcriptional regulator BSF20_11350 ENOG410904N short-chain dehydrogenase reductase BSF20_11365 ENOG4105C02 permease BSF20_11390 ENOG4105DAP Nicotinate phosphoribosyltransferase BSF20_11395 ENOG4105D58 Diguanylate phosphodiesterase BSF20_11430 ENOG4105KA0 thioesterase Superfamily protein BSF20_11435 ENOG4105KJM monovalent cation h antiporter subunit g BSF20_11445 ENOG4105SC1 monovalent cation H antiporter subunit E BSF20_11450 ENOG4108JPZ Monovalent cation H antiporter subunit D BSF20_11455 ENOG4108ZE9 Monovalent cation H antiporter subunit C BSF20_11460 ENOG4105HC0 Na H antiporter BSF20_11465 ENOG4105D65 subunit l BSF20_11480 ENOG4105UIB (ABC) transporter BSF20_11485 ENOG4108JQ9 ABC transporter BSF20_11490 ENOG4105DIH basic membrane BSF20_11495 ENOG4108MRH transcriptional regulatory protein BSF20_11510 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BSF20_11515 ENOG4105BZ4 penicillin-binding protein BSF20_11530 ENOG4105Y38 Kinase-associated protein B BSF20_11535 ENOG4108HGU Histidine kinase BSF20_11540 ENOG4105C87 Aminotransferase class I and II BSF20_11550 ENOG4108MUZ hydrolase BSF20_11555 ENOG4108ZB6 transcriptional regulator AsnC family BSF20_11560 ENOG4105CHM Aminotransferase BSF20_11570 ENOG4105WG9 Conserved Protein BSF20_11575 ENOG4107QW4 alcohol dehydrogenase BSF20_11585 ENOG4105CHJ isochorismatase hydrolase BSF20_11595 ENOG4107QYV phosphohexose isomerase BSF20_11610 ENOG4107PBV potassium channel BSF20_11615 ENOG4107PBV potassium channel BSF20_11630 ENOG4105C37 (CBS) domain BSF20_11640 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BSF20_11645 ENOG4105EA8 2-Nitropropane dioxygenase BSF20_11660 ENOG4105C8Q Methyl-accepting chemotaxis BSF20_11665 ENOG4105C8Q Methyl-accepting chemotaxis BSF20_11670 ENOG4105C8Q Methyl-accepting chemotaxis BSF20_11675 ENOG4105C8Q Methyl-accepting chemotaxis BSF20_11680 ENOG4108Z0Z intracellular protease Pfpi family BSF20_11685 ENOG4105EE0 oxidoreductase BSF20_11695 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BSF20_11740 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BSF20_11745 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BSF20_11760 ENOG4105TRT Transcriptional regulator BSF20_11765 ENOG4105C26 Dehydrogenase BSF20_11770 ENOG4108JB8 alcohol dehydrogenase BSF20_11775 ENOG4108VNY MOSC domain protein BSF20_11780 ENOG4106DF1 BSF20_11790 ENOG4105DZ6 Band 7 protein BSF20_11795 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BSF20_11930 ENOG4105E4F Isochorismate synthase BSF20_11935 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BSF20_11940 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BSF20_11945 ENOG4108IPT Naphthoate synthase BSF20_11950 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_11955 ENOG4105DTQ mandelate racemase muconate lactonizing BSF20_11975 ENOG4105NRA 50s ribosomal protein l31 type b BSF20_11980 ENOG4108V2W Carbonate dehydratase BSF20_11985 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BSF20_11990 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BSF20_12005 ENOG4108RMU ferritin dps family protein BSF20_12020 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BSF20_12030 ENOG4105D2X ABC transporter substrate-binding protein BSF20_12045 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BSF20_12050 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BSF20_12055 ENOG4105CAQ asparagine synthetase BSF20_12060 ENOG4105C85 amino acid BSF20_12065 ENOG4108Z0R Transferase BSF20_12070 ENOG4105E8V Alpha Beta Hydrolase Fold protein BSF20_12080 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BSF20_12095 ENOG4105N5T Radical SAM Protein BSF20_12115 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BSF20_12120 ENOG4105DVE abc transporter atp-binding protein BSF20_12140 ENOG4105C19 ABC transporter BSF20_12145 ENOG4107R34 abc transporter permease protein BSF20_12155 ENOG4105EWM Histidine kinase BSF20_12160 ENOG4105C19 ABC transporter BSF20_12175 ENOG410605W Major Facilitator BSF20_12180 ENOG4105BZU Histidine kinase BSF20_12190 ENOG4105C8T Leucyl-tRNA synthetase BSF20_12195 ENOG41085GJ domain protein BSF20_12210 ENOG4105I1K ABC transporter BSF20_12215 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BSF20_12235 ENOG4105C94 Transporter BSF20_12240 ENOG4105CBX hi0933 family BSF20_12255 ENOG4105YW5 deoR family transcriptional regulator BSF20_12270 ENOG4105C7N Xanthine uracil vitamin C permease BSF20_12275 ENOG4107QSE Dipeptidase BSF20_12280 ENOG4105C6T cysteine synthase BSF20_12285 ENOG4107F58 2'-5' rna ligase BSF20_12300 ENOG4108V15 phosphotransferase enzyme family BSF20_12310 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BSF20_12315 ENOG4105C8F Beta-lactamase domain protein BSF20_12320 ENOG4105C6K Malic enzyme BSF20_12335 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BSF20_12350 ENOG4108VDD TRNA binding domain protein BSF20_12360 ENOG4105DFU Cell wall formation (By similarity) BSF20_12380 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BSF20_12385 ENOG4105ETE Transcriptional regulator (LacI family BSF20_12390 ENOG4107R0U MotA TolQ exbB proton channel BSF20_12395 ENOG4105ER2 Ompa motb domain protein BSF20_12400 ENOG4105DGU Histone deacetylase BSF20_12405 ENOG4105W87 Cbs domain BSF20_12410 ENOG4105F1V Acetoin utilization protein BSF20_12420 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BSF20_12435 ENOG4108NGU Transcriptional regulator BSF20_12455 ENOG4108Z0Z intracellular protease Pfpi family BSF20_12465 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BSF20_12475 ENOG4105C26 Dehydrogenase BSF20_12480 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BSF20_12485 ENOG4105BZU Histidine kinase BSF20_12495 ENOG4105U5Y Transcriptional regulator BSF20_12520 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BSF20_12530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSF20_12535 ENOG4105EFZ amidohydrolase BSF20_12540 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BSF20_12545 ENOG4105D07 Signal peptide peptidase, SppA BSF20_12550 ENOG4105VK3 rdd domain containing protein BSF20_12560 ENOG4105KBJ sporulation protein ytfj BSF20_12565 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BSF20_12575 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BSF20_12580 ENOG4105EPU Molybdenum cofactor synthesis domain protein BSF20_12585 ENOG4105CDH Citrulline--aspartate ligase BSF20_12590 ENOG4105CH7 arginosuccinase BSF20_12600 ENOG4105E8R UPF0173 metal-dependent hydrolase BSF20_12615 ENOG4105SFS phosphoesterase RecJ domain protein BSF20_12620 ENOG4106EVM BSF20_12630 ENOG4105VV2 BSF20_12635 ENOG4105C0B DNA polymerase III (alpha subunit) BSF20_12640 ENOG4105C6K Malic enzyme BSF20_12650 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BSF20_12655 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BSF20_12660 ENOG4105CTQ phosphohexokinase BSF20_12665 ENOG4105CA9 Pyruvate kinase BSF20_12670 ENOG4105FS0 cytoplasmic membrane protein BSF20_12675 ENOG4108REF Sporulation integral membrane protein ytvi BSF20_12685 ENOG4105G7B Protein of unknown function (DUF2992) BSF20_12690 ENOG4105BZN citrate synthase BSF20_12695 ENOG4108HMX isocitrate dehydrogenase (NADP) BSF20_12705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSF20_12710 ENOG4105BZU Histidine kinase BSF20_12715 ENOG4105C2M dna polymerase I BSF20_12720 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BSF20_12730 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BSF20_12735 ENOG4105CV8 reductase BSF20_12740 ENOG4105F27 Major Facilitator BSF20_12745 ENOG4105KVH Transcriptional regulator BSF20_12750 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSF20_12755 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BSF20_12780 ENOG4108TDW sporulation protein YtxC BSF20_12785 ENOG4105C22 threonyL-tRNA synthetase BSF20_12790 ENOG4105U0R haloacid dehalogenase-like hydrolase BSF20_12795 ENOG4108HRK Histidine kinase BSF20_12800 ENOG4105DY9 regulatoR BSF20_12810 ENOG41067MG lrgb family BSF20_12815 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BSF20_12820 ENOG4105VJV 50s ribosomal protein L35 BSF20_12825 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BSF20_12830 ENOG410696E Membrane BSF20_12840 ENOG4105CN9 Peptidase m42 family protein BSF20_12845 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BSF20_12855 ENOG4105EF1 ribulokinase BSF20_12860 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BSF20_12870 ENOG4108MDK Dehydrogenase BSF20_12885 ENOG4105DRS transport system, permease BSF20_12890 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BSF20_12900 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BSF20_12905 ENOG4105CQB FAD linked oxidase domain protein BSF20_12915 ENOG41067MF small acid-soluble spore protein BSF20_12920 ENOG4108RWN rrna methyltransferase BSF20_12925 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BSF20_12930 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BSF20_12935 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSF20_12950 ENOG4105DCG PHP domain protein BSF20_12955 ENOG4105C98 muts2 protein BSF20_12970 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_12975 ENOG4107Z3H Transcriptional regulator, TetR family BSF20_12980 ENOG41060WC Enoyl-CoA hydratase BSF20_12985 ENOG4105BZJ Electron transfer flavoprotein BSF20_12990 ENOG4105C10 Electron transfer flavoprotein BSF20_12995 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BSF20_13000 ENOG4105K63 Thioredoxin BSF20_13005 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BSF20_13010 ENOG4105CFH Aspartokinase BSF20_13020 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BSF20_13030 ENOG4105E33 succinate dehydrogenase BSF20_13040 ENOG4105PFC Transcriptional regulator BSF20_13045 ENOG41067TZ transcriptional regulator, MarR family BSF20_13050 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BSF20_13055 ENOG4108XJQ germination protein BSF20_13060 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BSF20_13065 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BSF20_13070 ENOG4105M59 Phosphodiesterase, mj0936 family BSF20_13090 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BSF20_13120 ENOG4105C7K acetolactate synthase BSF20_13125 ENOG4108ZP8 Acetolactate synthase small subunit BSF20_13130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BSF20_13140 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BSF20_13145 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSF20_13150 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSF20_13160 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BSF20_13165 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BSF20_13170 ENOG4108IUQ atp-dependent protease BSF20_13175 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BSF20_13180 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BSF20_13190 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BSF20_13200 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BSF20_13210 ENOG4105D52 delta-aminolevulinic acid dehydratase BSF20_13215 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BSF20_13220 ENOG41068KH stage VI sporulation protein D BSF20_13225 ENOG4106AR7 Spore coat protein BSF20_13235 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BSF20_13240 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BSF20_13245 ENOG4106A3R peptidase BSF20_13255 ENOG4108Z03 MAF-like protein BSF20_13260 ENOG4105W5Q DNA repair protein (RadC BSF20_13265 ENOG4105DFF Rod shape-determining protein mreb BSF20_13270 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BSF20_13275 ENOG4105YHC Rod shape-determining protein MreD BSF20_13280 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BSF20_13285 ENOG4107QMS site-determining protein BSF20_13300 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BSF20_13305 ENOG4105X36 (ribosomal) protein BSF20_13310 ENOG4105K46 50S ribosomal protein l27 BSF20_13320 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BSF20_13330 ENOG4105CQC Prephenate dehydratase BSF20_13345 ENOG4108IYU L-aspartate oxidase BSF20_13350 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BSF20_13355 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BSF20_13360 ENOG4106678 morphogenetic protein associated with SpoVID BSF20_13380 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BSF20_13385 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BSF20_13390 ENOG41061AI Protein of unknown function (DUF2905) BSF20_13395 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BSF20_13400 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BSF20_13405 ENOG4105VIE preprotein translocase, subunit YajC BSF20_13410 ENOG4105NAP BSF20_13415 ENOG4108QG2 Membrane BSF20_13420 ENOG4105CKP Polysaccharide Biosynthesis Protein BSF20_13430 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSF20_13435 ENOG4105NCW Trka-c domain protein BSF20_13440 ENOG41067VP Protein of unknown function (DUF1049) BSF20_13445 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BSF20_13455 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BSF20_13460 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BSF20_13465 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSF20_13470 ENOG4105CUT histidyl-tRNA synthetase BSF20_13475 ENOG4105C9M aspartyl-trna synthetase BSF20_13485 ENOG4105CUZ uba thif-type nad fad binding protein BSF20_13490 ENOG4105D1H recombination factor protein RarA BSF20_13500 ENOG4105C3J Cysteine desulfurase BSF20_13505 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BSF20_13515 ENOG4105C7H Helicase, RecD TraA family BSF20_13525 ENOG41060CR BSF20_13535 ENOG4105DRP amino acid AbC transporter BSF20_13540 ENOG4105EAD ABC transporter BSF20_13545 ENOG4105CT1 (ABC) transporter BSF20_13550 ENOG4105CDA abc transporter atp-binding protein BSF20_13555 ENOG4105C02 permease BSF20_13560 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BSF20_13565 ENOG4105VBH UPF0297 protein BSF20_13570 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BSF20_13580 ENOG4105HHA aminodeoxychorismate lyase BSF20_13585 ENOG4108VQJ O-methyltransferase BSF20_13590 ENOG4105XYU peptidase (U32 family) BSF20_13595 ENOG4105CFP Peptidase U32 BSF20_13605 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BSF20_13610 ENOG4107XRG penicillin-binding protein BSF20_13640 ENOG4105C28 cystathionine BSF20_13655 ENOG4108JB9 formate dehydrogenase BSF20_13660 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BSF20_13665 ENOG4105TMB Formate nitrite transporter BSF20_13685 ENOG41082JN Transcriptional regulator BSF20_13690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSF20_13695 ENOG4105D94 Major Facilitator Superfamily BSF20_13700 ENOG4107RSM transcriptional regulator BSF20_13705 ENOG4108Z66 YbaK ebsC protein BSF20_13720 ENOG4105DM4 PTS System BSF20_13725 ENOG4105DG6 mannose-6-phosphate isomerase BSF20_13735 ENOG4108HCJ Hydrolase BSF20_13755 ENOG4108U7W acetyltransferase BSF20_13760 ENOG4108J8C transporter major facilitator family protein BSF20_13765 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BSF20_13785 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_13795 ENOG41080BT SNARE associated Golgi BSF20_13815 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BSF20_13820 ENOG4105CQW ribosome biogenesis GTPase YqeH BSF20_13825 ENOG4105E2X shikimate dehydrogenase BSF20_13830 ENOG410812S Rna-binding protein BSF20_13835 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BSF20_13840 ENOG4108WF2 Metal Dependent Phosphohydrolase BSF20_13850 ENOG4108D32 Methyltransferase BSF20_13860 ENOG4105KQC Competence protein BSF20_13865 ENOG4108UK2 deaminase BSF20_13870 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BSF20_13880 ENOG4105TQK DNA polymerase iii, delta' subunit BSF20_13885 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BSF20_13890 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BSF20_13895 ENOG4108ZRV stage ii sporulation protein p BSF20_13905 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BSF20_13910 ENOG4105CSA Coproporphyrinogen iii oxidase BSF20_13915 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BSF20_13920 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BSF20_13925 ENOG4105CFG Acts as a chaperone (By similarity) BSF20_13930 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BSF20_13935 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BSF20_13940 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BSF20_13945 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BSF20_13960 ENOG4105KTH gatB Yqey BSF20_13965 ENOG4105F7J membrane-bound serine protease BSF20_13970 ENOG4105DI5 UPF0365 protein BSF20_13980 ENOG41068P3 sporulation protein YqfC BSF20_13985 ENOG4105EI1 sporulation protein yqfd BSF20_13990 ENOG4105C9A Phoh family BSF20_13995 ENOG4105CTJ Metal Dependent Phosphohydrolase BSF20_14000 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BSF20_14005 ENOG4107YR5 Diacylglycerol kinase BSF20_14010 ENOG4105KG3 cytidine deaminase BSF20_14015 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BSF20_14025 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BSF20_14030 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BSF20_14035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BSF20_14045 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BSF20_14050 ENOG4108UPT UPF0178 protein BSF20_14055 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BSF20_14060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_14075 ENOG4105EGD dinuclear metal center protein, YbgI family BSF20_14080 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BSF20_14095 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BSF20_14100 ENOG41069ZM Protein of unknown function (DUF2624) BSF20_14105 ENOG4108JYZ YitT family BSF20_14110 ENOG4105N80 Ferric uptake regulator, Fur family BSF20_14115 ENOG4108U5J '-nucleotidase BSF20_14120 ENOG41063Y9 BSF20_14125 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BSF20_14140 ENOG4105SXS Protein of unknown function (DUF456) BSF20_14145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BSF20_14155 ENOG4107RF6 penicillin-binding protein BSF20_14160 ENOG4105CVA phosphate BSF20_14165 ENOG4105C8U phosphate abc transporter BSF20_14170 ENOG4105E2Z phosphate ABC transporter (Permease BSF20_14175 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSF20_14180 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSF20_14185 ENOG41068DG YceG-like family BSF20_14195 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BSF20_14235 ENOG4105C5X domain protein BSF20_14260 ENOG4105C37 (CBS) domain BSF20_14320 ENOG4105VFR signal peptidase BSF20_14330 ENOG4108IMY Transcriptional regulator BSF20_14345 ENOG4105C0D helicase BSF20_14350 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BSF20_14360 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BSF20_14365 ENOG4105WZW rhodanese family BSF20_14370 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BSF20_14390 ENOG4105CBJ Metal-dependent enzyme BSF20_14400 ENOG4105DC7 peptidase M24 BSF20_14405 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BSF20_14415 ENOG4105CD2 stage iii sporulation protein aa BSF20_14420 ENOG4105KR5 Stage iii sporulation protein BSF20_14425 ENOG4108CQH stage III sporulation protein AC BSF20_14430 ENOG4105KQ4 Stage iii sporulation protein ad BSF20_14440 ENOG410644B Stage III sporulation protein af BSF20_14460 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BSF20_14465 ENOG4108ZSR alkaline shock protein BSF20_14470 ENOG4105M7K Involved in the transcription termination process (By similarity) BSF20_14475 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BSF20_14480 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSF20_14485 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSF20_14490 ENOG4105CTB Polyprenyl synthetase BSF20_14495 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BSF20_14500 ENOG4105DX0 Hemolysin A BSF20_14505 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BSF20_14510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BSF20_14515 ENOG4105S1Z Stage IV sporulation protein B BSF20_14520 ENOG4107QQR Sporulation BSF20_14525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BSF20_14540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSF20_14565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSF20_14570 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BSF20_14580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BSF20_14585 ENOG4105C1G acyl-Coa dehydrogenase BSF20_14595 ENOG4105DXD 2-methylcitrate dehydratase BSF20_14600 ENOG4105CR4 methylisocitrate lyase BSF20_14605 ENOG4106CCJ Protein of unknown function (DUF2627) BSF20_14610 ENOG4108JUB Transcriptional regulator BSF20_14620 ENOG4107RDP Dehydrogenase BSF20_14625 ENOG4105CKM Branched-chain carboxylic acid kinase BSF20_14640 ENOG4105CPP Dehydrogenase, E1 component BSF20_14645 ENOG4105C7S Dehydrogenase BSF20_14650 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BSF20_14655 ENOG4108Y6J UPF0403 protein BSF20_14660 ENOG4108HW3 (ABC) transporter BSF20_14665 ENOG4105E5Q amino acid AbC transporter BSF20_14670 ENOG4105CDA abc transporter atp-binding protein BSF20_14675 ENOG4108QEG Membrane BSF20_14680 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BSF20_14685 ENOG4108ZVT methylmalonyl-coA epimerase BSF20_14690 ENOG4108HNZ carboxyl transferase BSF20_14695 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSF20_14700 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BSF20_14710 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BSF20_14715 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BSF20_14720 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BSF20_14725 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BSF20_14735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSF20_14745 ENOG4108K70 Transcriptional regulator BSF20_14750 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BSF20_14755 ENOG4107QKG PfaD family BSF20_14770 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_14775 ENOG4105CHR reductase BSF20_14785 ENOG4105C0W non-ribosomal peptide synthetase BSF20_14795 ENOG4105C0W non-ribosomal peptide synthetase BSF20_14800 ENOG4105C0W non-ribosomal peptide synthetase BSF20_14815 ENOG4106A3M Cytochrome p-450 BSF20_14820 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BSF20_14825 ENOG4108KQ6 Enoyl-CoA hydratase BSF20_14830 ENOG4105II7 pyrroline-5-carboxylate reductase BSF20_14835 ENOG41069FQ Metallo-beta-lactamase superfamily BSF20_14840 ENOG4108IXY short-chain dehydrogenase reductase BSF20_14850 ENOG4105CS9 pantothenic acid kinase BSF20_14855 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BSF20_14860 ENOG4105C02 permease BSF20_14875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BSF20_14880 ENOG4108XET gCN5-related N-acetyltransferase BSF20_14885 ENOG4105KAC Antibiotic biosynthesis monooxygenase BSF20_14890 ENOG4105RHY Pfam:UPF0157 BSF20_14895 ENOG4106HZJ BSF20_14915 ENOG4105CPC Aldo Keto reductase BSF20_14925 ENOG4108YZ4 nudix hydrolase BSF20_14935 ENOG4108IMY Transcriptional regulator BSF20_14940 ENOG4105HDK L-asparaginase BSF20_14945 ENOG4108IJ0 Aspartate ammonia-lyase BSF20_14950 ENOG4105DFD Na H antiporter BSF20_14970 ENOG4105MZ9 stage II sporulation protein m BSF20_14975 ENOG4105I3K Ferric uptake regulator, Fur family BSF20_14985 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSF20_14990 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BSF20_14995 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BSF20_15000 ENOG4105DZ1 carboxypeptidase BSF20_15005 ENOG41082AN stage II sporulation protein BSF20_15010 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BSF20_15015 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_15030 ENOG41090VF Stage v sporulation protein ac BSF20_15035 ENOG4105CZ3 stage V sporulation protein ad BSF20_15045 ENOG4105G6R Stage v sporulation protein ae BSF20_15055 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BSF20_15060 ENOG4105PTM secreted protein BSF20_15065 ENOG4107ZE5 PPIases accelerate the folding of proteins BSF20_15090 ENOG4108R6K riboflavin synthase, subunit alpha BSF20_15095 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BSF20_15100 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BSF20_15115 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BSF20_15120 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BSF20_15130 ENOG4105DZ1 carboxypeptidase BSF20_15135 ENOG4108JIC nucleoside recognition domain protein BSF20_15145 ENOG4105FE9 pseudouridine synthase BSF20_15155 ENOG4107TWT Cytochrome c biogenesis protein BSF20_15160 ENOG4105CRE cytochrome C BSF20_15165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSF20_15170 ENOG4105BZU Histidine kinase BSF20_15185 ENOG4108JQ1 Dehydrogenase BSF20_15190 ENOG4108SAX Membrane BSF20_15200 ENOG4105T7X BSF20_15205 ENOG4105C9U ATP-dependent DNA helicase RecQ BSF20_15210 ENOG4105I7S Abortive infection protein BSF20_15225 ENOG4107RGJ metallophosphoesterase BSF20_15240 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BSF20_15245 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BSF20_15255 ENOG4105MSI germination protein ypeb BSF20_15265 ENOG4105CAT Cytidine monophosphate kinase BSF20_15270 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BSF20_15290 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BSF20_15295 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BSF20_15310 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BSF20_15315 ENOG4105K70 DNA-binding protein BSF20_15320 ENOG4105EUJ GTP cyclohydrolase i BSF20_15325 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BSF20_15330 ENOG4105XXQ heptaprenyl diphosphate synthase component I BSF20_15335 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BSF20_15340 ENOG4105EAH synthase BSF20_15345 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BSF20_15350 ENOG4105BZU Histidine kinase BSF20_15355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BSF20_15365 ENOG4105KHN chorismate mutase BSF20_15370 ENOG4105CRQ synthase (Component I) BSF20_15380 ENOG4105DK0 Indole-3-glycerol phosphate synthase BSF20_15385 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BSF20_15390 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BSF20_15400 ENOG4105CIH Imidazole acetol-phosphate transaminase BSF20_15410 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BSF20_15415 ENOG41068YB TPR repeat-containing protein BSF20_15435 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BSF20_15455 ENOG4105F0F Oxalate decarboxylase BSF20_15460 ENOG4108JYZ YitT family BSF20_15465 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BSF20_15470 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BSF20_15475 ENOG4108Z5K methylglyoxal synthase BSF20_15480 ENOG4105FJR Lmbe family BSF20_15485 ENOG4105CPK Glycosyl transferase (Group 1 BSF20_15490 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BSF20_15500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BSF20_15510 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BSF20_15515 ENOG4105DVT helicase BSF20_15520 ENOG4105YAC BSF20_15530 ENOG4105CHM Aminotransferase BSF20_15535 ENOG4105C5S asparaginyl-tRNA synthetase BSF20_15545 ENOG4105CSM endonuclease III BSF20_15555 ENOG4105BZ4 penicillin-binding protein BSF20_15560 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BSF20_15605 ENOG4108I5C dEAD DEAH box helicase BSF20_15610 ENOG4107X2U Inherit from COG: Exonuclease-like protein BSF20_15615 ENOG4108UKS UPF0398 protein BSF20_15620 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BSF20_15630 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BSF20_15640 ENOG4105DVT helicase BSF20_15645 ENOG4105CTD carboxy-peptidase BSF20_15650 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BSF20_15655 ENOG4105C2W permease BSF20_15690 ENOG41065KQ synthase BSF20_15700 ENOG410890F Dynamin family BSF20_15720 ENOG41081VK Ribonuclease BSF20_15760 ENOG4105CVG Homoserine O-transsuccinylase BSF20_15765 ENOG4108V06 Glutathione peroxidase BSF20_15780 ENOG4105C01 Dihydroxy-acid dehydratase BSF20_15785 ENOG4108Y6J UPF0403 protein BSF20_15790 ENOG4107YX5 Pfam:DUF548 BSF20_15800 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BSF20_15805 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BSF20_15815 ENOG4108UT2 hemolysin iii BSF20_15825 ENOG4105C7B Threonine dehydratase BSF20_15835 ENOG4108KF3 Electron transport protein SCO1 SenC BSF20_15840 ENOG41090WU lipolytic protein G-D-S-L family BSF20_15845 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BSF20_15855 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BSF20_15860 ENOG4105E0X reductase BSF20_15890 ENOG4107Y9E nuclease BSF20_15905 ENOG4106ANW SMI1_KNR4 BSF20_16035 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSF20_16050 ENOG4107S4Y M20 DapE family protein YgeY BSF20_16055 ENOG4108TSC N-acetyltransferase BSF20_16060 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BSF20_16095 ENOG410841Q phosphoesterase PA-phosphatase related protein BSF20_16100 ENOG4106Z5R BSF20_16105 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BSF20_16110 ENOG4108VXD carboxy-peptidase BSF20_16130 ENOG4108S3Y transcriptional regulator BSF20_16135 ENOG4105CS2 ec 3.2.1.21 BSF20_16145 ENOG4105E1V na solute symporter BSF20_16160 ENOG4105FBA Phospholipase Carboxylesterase BSF20_16180 ENOG41090U3 tautomerase BSF20_16195 ENOG4105FR1 rard protein BSF20_16215 ENOG4106SCS STAS domain BSF20_16220 ENOG4107QMU Mate efflux family protein BSF20_16230 ENOG41087PP glycosyltransferase MGT family BSF20_16235 ENOG4105K4H Nlp p60 protein BSF20_16245 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BSF20_16250 ENOG4107T89 von Willebrand factor, type A BSF20_16255 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BSF20_16260 ENOG4105C7S Dehydrogenase BSF20_16270 ENOG4105C09 Bile acid BSF20_16275 ENOG4105C8J )-transporter BSF20_16280 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BSF20_16285 ENOG4105EWU Squalene--hopene cyclase BSF20_16290 ENOG4105C26 Dehydrogenase BSF20_16330 ENOG4105SCY DNAK suppressor BSF20_16335 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BSF20_16345 ENOG4105C9U ATP-dependent DNA helicase RecQ BSF20_16350 ENOG41069ER domain protein BSF20_16375 ENOG4108SJC Membrane BSF20_16385 ENOG4105KTU Transcriptional regulator, arsr family BSF20_16395 ENOG4108W8B Beta-lactamase domain protein BSF20_16405 ENOG4105FTV AraC Family Transcriptional Regulator BSF20_16410 ENOG4108Z7R Chaperone CsaA BSF20_16420 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BSF20_16440 ENOG4108J2R molybdopterin oxidoreductase BSF20_16445 ENOG4108M3J Dehydrogenase BSF20_16450 ENOG4107U6E carbohydrate kinase FGGY BSF20_16455 ENOG4105IE8 Alpha-ketoglutarate permease BSF20_16460 ENOG4108UB7 BSF20_16485 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BSF20_16490 ENOG4105C5Q Transcriptional regulator BSF20_16495 ENOG4105CBC glutamate synthase BSF20_16500 ENOG4105BZ8 glutamate synthase BSF20_16505 ENOG4105CB2 alcohol dehydrogenase BSF20_16510 ENOG4108KSA LysR family transcriptional regulator BSF20_16515 ENOG4105C22 threonyL-tRNA synthetase BSF20_16520 ENOG4105WAB arsR family transcriptional regulator BSF20_16525 ENOG4108RWP Major Facilitator Superfamily protein BSF20_16530 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BSF20_16555 ENOG4107QJQ Mate efflux family protein BSF20_16560 ENOG4108N2V aldose 1-epimerase BSF20_16565 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BSF20_16570 ENOG4105C0W non-ribosomal peptide synthetase BSF20_16580 ENOG4105C0W non-ribosomal peptide synthetase BSF20_16585 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_16595 ENOG4106U2H Protein of unknown function (DUF1360) BSF20_16600 ENOG4105F32 YngK protein BSF20_16605 ENOG4105C1G acyl-Coa dehydrogenase BSF20_16610 ENOG4105CEY Amp-dependent synthetase and ligase BSF20_16615 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BSF20_16620 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BSF20_16625 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BSF20_16630 ENOG4105E39 Enoyl-CoA hydratase BSF20_16635 ENOG4107QX3 carboxylase BSF20_16640 ENOG4107T5V SNARE associated Golgi BSF20_16645 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BSF20_16655 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) BSF20_16660 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSF20_16665 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BSF20_16670 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BSF20_16675 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BSF20_16680 ENOG4106A3M Cytochrome p-450 BSF20_16685 ENOG4105CY2 Citrate transporter BSF20_16690 ENOG4105D6N CoA-transferase, subunit a BSF20_16695 ENOG4108IIH CoA-transferase subunit B BSF20_16700 ENOG4105DTD Dehydrogenase BSF20_16725 ENOG4107SYN Glycosyl hydrolases family 43 BSF20_16735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSF20_16770 ENOG4105FVX BSF20_16785 ENOG4108I5G Major Facilitator superfamily BSF20_16795 ENOG4105DMW Dehydrogenase reductase BSF20_16800 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BSF20_16805 ENOG4108UHU Aldolase BSF20_16810 ENOG4105CPQ Dehydrogenase BSF20_16835 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSF20_16840 ENOG4105K4P CoA-binding domain protein BSF20_16845 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BSF20_16850 ENOG4105W8X HesB YadR YfhF-family protein BSF20_16855 ENOG4105MI2 BSF20_16865 ENOG41067CD Small, acid-soluble spore protein Tlp BSF20_16880 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSF20_16885 ENOG4108I0Z Aconitate hydratase BSF20_16920 ENOG4107QIV Cytochrome c biogenesis protein BSF20_16930 ENOG4105VXM UPF0154 protein BSF20_16940 ENOG4105CV1 Transketolase (EC 2.2.1.1) BSF20_16945 ENOG4105VPS UPF0291 protein BSF20_16950 ENOG4108SVB resolvase BSF20_16960 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BSF20_16980 ENOG4105K7W phage-related replication protein BSF20_16985 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BSF20_17005 ENOG4108M1A Chitin-binding protein BSF20_17025 ENOG4105EPI acetyltransferase, (GNAT) family BSF20_17035 ENOG4105DQ4 alcohol dehydrogenase BSF20_17045 ENOG4105D29 Helix-turn-helix type 11 domain protein BSF20_17065 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BSF20_17070 ENOG4105CMG Carbohydrate kinase BSF20_17075 ENOG4105C93 Xylose Isomerase BSF20_17085 ENOG4105DSG hydrolase family 43 BSF20_17090 ENOG4105CT4 transporter BSF20_17105 ENOG41064BW Protein of unknown function (DUF2568) BSF20_17125 ENOG4105C5F glutamine synthetase BSF20_17130 ENOG4105KV4 Transcriptional regulator BSF20_17135 ENOG4105CXI aluminum resistance protein BSF20_17140 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BSF20_17145 ENOG4106F1P AAA ATPase, central domain protein BSF20_17155 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSF20_17160 ENOG4105U6W MutT NUDIX family protein BSF20_17165 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSF20_17170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSF20_17195 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BSF20_17220 ENOG4108X3M OsmC Ohr family protein BSF20_17225 ENOG4105K7W phage-related replication protein BSF20_17235 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSF20_17245 ENOG4105XPP Protein of unknown function (DUF1275) BSF20_17250 ENOG4105WFK nuclease BSF20_17255 ENOG4106A3M Cytochrome p-450 BSF20_17265 ENOG4105C0W non-ribosomal peptide synthetase BSF20_17275 ENOG4107SQU synthase BSF20_17280 ENOG4105C0W non-ribosomal peptide synthetase BSF20_17285 ENOG4108KQ6 Enoyl-CoA hydratase BSF20_17290 ENOG4108MGH Enoyl-CoA hydratase BSF20_17295 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BSF20_17300 ENOG41062T2 Acyl carrier protein BSF20_17305 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSF20_17310 ENOG4108JA1 polyketide synthase BSF20_17315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSF20_17320 ENOG4108151 Beta-lactamase domain protein BSF20_17330 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BSF20_17350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BSF20_17355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BSF20_17360 ENOG4105CPQ Dehydrogenase BSF20_17365 ENOG4105MCT stage V sporulation protein S BSF20_17370 ENOG4105D48 metallophosphoesterase BSF20_17380 ENOG4108A04 Beta-lactamase BSF20_17385 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BSF20_17390 ENOG4105CEV competence damage-inducible protein BSF20_17395 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BSF20_17410 ENOG4105XZV Protein of unknown function (DUF3243) BSF20_17415 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BSF20_17430 ENOG4105EYF MMPL domain protein BSF20_17445 ENOG4105FDP GntR family transcriptional regulator BSF20_17450 ENOG4105CNU cell division protein FtsK BSF20_17460 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BSF20_17470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BSF20_17480 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BSF20_17485 ENOG4108S0H Dipicolinic acid synthetase, b subunit BSF20_17490 ENOG4105E35 Dipicolinate synthase subunit A BSF20_17500 ENOG4105C1V Peptidase, M16 BSF20_17510 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BSF20_17515 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BSF20_17520 ENOG4105DTN riboflavin biosynthesis protein ribF BSF20_17525 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BSF20_17530 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BSF20_17535 ENOG4105W7A Protein of unknown function (DUF503) BSF20_17540 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BSF20_17545 ENOG4105VHM ribosomal protein BSF20_17550 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BSF20_17555 ENOG4105CHV Transcription elongation factor NusA BSF20_17560 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BSF20_17565 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BSF20_17570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BSF20_17575 ENOG4105DZP Membrane-associated zinc metalloprotease BSF20_17585 ENOG4105KNE Phosphatidate cytidylyltransferase BSF20_17590 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BSF20_17595 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BSF20_17600 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BSF20_17610 ENOG4105CE9 30S ribosomal protein S2 BSF20_17620 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_17625 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BSF20_17635 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BSF20_17640 ENOG4105CBS Chea signal transduction histidine kinase BSF20_17645 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BSF20_17655 ENOG4105FZW flagellar biosynthesis regulator FlhF BSF20_17660 ENOG4105D7B Flagellar biosynthesis protein flha BSF20_17665 ENOG4105D00 flagellar biosynthetic protein flhB BSF20_17670 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BSF20_17675 ENOG4105VS8 Flagellar biosynthetic protein fliq BSF20_17680 ENOG4105CN7 Flagellar biosynthetic protein FliP BSF20_17690 ENOG4107YTP response regulator receiver protein BSF20_17695 ENOG4105DD5 Flagellar motor switch protein BSF20_17700 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSF20_17710 ENOG41068WV flagellar FlbD family protein BSF20_17715 ENOG4108JQA flagellar BSF20_17720 ENOG410822I Flagellar hook capping protein BSF20_17725 ENOG410696Y Flagellar hook-length control protein BSF20_17735 ENOG4106YF4 Flagellar biosynthesis chaperone BSF20_17750 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSF20_17755 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BSF20_17760 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BSF20_17765 ENOG4108ZC9 flagellar basal-body rod protein flgc BSF20_17770 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BSF20_17780 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BSF20_17785 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BSF20_17790 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSF20_17795 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BSF20_17800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BSF20_17805 ENOG4105C79 DNA protecting protein DprA BSF20_17810 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BSF20_17815 ENOG4105CMV Succinyl-CoA synthetase subunit beta BSF20_17820 ENOG4105VM1 flagellar BSF20_17830 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSF20_17835 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BSF20_17840 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BSF20_17845 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BSF20_17860 ENOG4108BW8 UPF0109 protein BSF20_17865 ENOG4105K5M 30s ribosomal protein S16 BSF20_17875 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BSF20_17885 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BSF20_17890 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BSF20_17895 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BSF20_17900 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BSF20_17905 ENOG4105CHR reductase BSF20_17910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSF20_17915 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BSF20_17920 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BSF20_17925 ENOG4105CB5 ATP-dependent DNA helicase recG BSF20_17930 ENOG4105EJQ L-serine dehydratase BSF20_17940 ENOG4105DP4 dak2 domain fusion protein ylov BSF20_17945 ENOG4108ZAA Alkaline-shock protein BSF20_17950 ENOG4105VB9 50S ribosomal protein l28 BSF20_17960 ENOG4105FJ0 thiamine BSF20_17965 ENOG4105DJV ribulose-phosphate 3-epimerase BSF20_17970 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BSF20_17975 ENOG4105D9P serine threonine protein kinase BSF20_17980 ENOG4108ZF3 Phosphatase BSF20_17985 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BSF20_17990 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BSF20_17995 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BSF20_18000 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BSF20_18005 ENOG4105C25 Primosomal protein n' BSF20_18010 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BSF20_18020 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BSF20_18025 ENOG4105KC4 UPF0296 protein BSF20_18030 ENOG4105DSJ YicC domain protein BSF20_18040 ENOG4105F23 Fibronectin-binding protein BSF20_18045 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BSF20_18050 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BSF20_18055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSF20_18065 ENOG4107RIQ Sulfate adenylate transferase BSF20_18080 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BSF20_18085 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BSF20_18090 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BSF20_18095 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BSF20_18100 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BSF20_18105 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BSF20_18115 ENOG4105CXT aspartate transcarbamylase BSF20_18125 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BSF20_18130 ENOG4105C34 Pseudouridine synthase BSF20_18135 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BSF20_18145 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BSF20_18160 ENOG4105DBK s4 domain protein BSF20_18165 ENOG41067XK integral membrane protein BSF20_18170 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BSF20_18175 ENOG4105DFA alanine racemase domain protein BSF20_18180 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BSF20_18185 ENOG4105WR5 sporulation protein, YlmC YmxH family BSF20_18195 ENOG4105DKW ABC transporter BSF20_18205 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSF20_18210 ENOG4105FFI sigma-e processing peptidase spoiiga BSF20_18220 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BSF20_18225 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BSF20_18230 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BSF20_18235 ENOG4105D4A Cell wall formation (By similarity) BSF20_18240 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BSF20_18245 ENOG4105CNI cell division protein FtsW BSF20_18250 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BSF20_18255 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BSF20_18260 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BSF20_18265 ENOG4105CJN penicillin-binding protein BSF20_18270 ENOG4105CJN penicillin-binding protein BSF20_18280 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BSF20_18285 ENOG4108V6E Cell division protein mraZ BSF20_18310 ENOG4105KNH Nucleic acid-binding protein BSF20_18315 ENOG4105CDE UPF0348 protein BSF20_18320 ENOG41063PX domain protein BSF20_18325 ENOG4105D78 K07001 NTE family protein BSF20_18330 ENOG4105H20 Sporulation integral membrane protein YlbJ BSF20_18335 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BSF20_18340 ENOG4106H78 methyltransferase BSF20_18370 ENOG4106UY4 Inherit from COG: Scp-like extracellular BSF20_18375 ENOG41080XQ Signal transduction protein with cbs domains BSF20_18390 ENOG41064X9 cytochrome C oxidase subunit IV BSF20_18395 ENOG4105CCU oxidase (Subunit III) BSF20_18400 ENOG4105BZ9 Cytochrome C oxidase, subunit I BSF20_18410 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BSF20_18420 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BSF20_18425 ENOG4105CNI cell division protein FtsW BSF20_18435 ENOG4105CSV Glutaminase BSF20_18445 ENOG4108IAB Phoh family BSF20_18460 ENOG4105QA2 BSF20_18465 ENOG4105CI3 gtp-binding protein typa BSF20_18485 ENOG4105D4Y metalloprotease BSF20_18495 ENOG4105ECY inositol monophosphatase BSF20_18510 ENOG4105WBI UPF0223 protein BSF20_18520 ENOG4105CXN decarboxylase BSF20_18535 ENOG4107QN2 dihydrolipoyl dehydrogenase BSF20_18540 ENOG4105C7S Dehydrogenase BSF20_18545 ENOG4105CPP Dehydrogenase, E1 component BSF20_18555 ENOG4105FQP Beta-lactamase BSF20_18560 ENOG4105C0W non-ribosomal peptide synthetase BSF20_18565 ENOG4107SQU synthase BSF20_18570 ENOG4107SQU synthase BSF20_18575 ENOG4107SQU synthase BSF20_18580 ENOG4105C0W non-ribosomal peptide synthetase BSF20_18585 ENOG4107SQU synthase BSF20_18590 ENOG4105C0W non-ribosomal peptide synthetase BSF20_18595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSF20_18610 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BSF20_18615 ENOG4108X4Q Hydrolase BSF20_18620 ENOG4106148 UPF0356 protein BSF20_18625 ENOG4105CN5 Metallo-Beta-Lactamase BSF20_18630 ENOG4105CPN adenine deaminase BSF20_18635 ENOG4107ZYR domain protein BSF20_18645 ENOG4105BZU Histidine kinase BSF20_18670 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BSF20_18675 ENOG4105C5H ABC transporter BSF20_18690 ENOG4105DM4 PTS System BSF20_18695 ENOG4105DE4 1-phosphofructokinase BSF20_18700 ENOG4105E98 transcriptional regulator DeoR family BSF20_18705 ENOG4107RBB ABC transporter, permease BSF20_18710 ENOG4105C19 ABC transporter BSF20_18715 ENOG4107X8C Efflux transporter RND family MFP subunit BSF20_18725 ENOG41067WU Molybdopterin converting factor (Subunit 1) BSF20_18730 ENOG4108ZAF Molybdopterin BSF20_18735 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BSF20_18740 ENOG4105CVM Molybdenum cofactor synthesis domain protein BSF20_18745 ENOG4105D06 uba thif-type nad fad binding protein BSF20_18750 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BSF20_18765 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSF20_18770 ENOG4105D8X mechanosensitive ion channel BSF20_18790 ENOG4105NQC Flavodoxin BSF20_18820 ENOG4108XRC Protein of unknown function (DUF458) BSF20_18825 ENOG4107IN1 Protein of unknown function (DUF1797) BSF20_18830 ENOG4105EPM Diguanylate phosphodiesterase BSF20_18840 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BSF20_18850 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BSF20_18860 ENOG4105UIN BSF20_18865 ENOG4107R88 Chemotaxis protein (CheV) BSF20_18870 ENOG4105CHM Aminotransferase BSF20_18875 ENOG4105BZU Histidine kinase BSF20_18885 ENOG4105K4I Scp-like extracellular BSF20_18890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BSF20_18895 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BSF20_18900 ENOG4105F6S Spore photoproduct lyase BSF20_18910 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BSF20_18915 ENOG4105KRI phosphocarrier protein (HPr BSF20_18925 ENOG4105CID antiterminator BSF20_18935 ENOG4105DC7 peptidase M24 BSF20_18940 ENOG4105C59 p-type ATPase BSF20_18955 ENOG4105F0V Cell wall hydrolase BSF20_18980 ENOG4105VTR Integrase BSF20_19015 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BSF20_19035 ENOG41068G1 BSF20_19050 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BSF20_19190 ENOG4108J9Q DNA ligase BSF20_19210 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the BSF20_19245 ENOG41069ER domain protein BSF20_19250 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BSF20_19270 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSF20_19280 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSF20_19285 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BSF20_19335 ENOG4105C2M dna polymerase I BSF20_19450 ENOG4105VTR Integrase BSF20_19485 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BSF20_19505 ENOG41068G1