locus-tag class description WV34_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) WV34_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WV34_00015 ENOG410848D S4 domain protein YaaA WV34_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WV34_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WV34_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WV34_00060 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WV34_00070 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) WV34_00075 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) WV34_00080 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) WV34_00085 ENOG4105BZW Glycerate kinase WV34_00095 ENOG4105ZMH deoxynucleoside kinase WV34_00105 ENOG4105VRS hydrolase family 18 WV34_00110 ENOG4105GTG Isochorismatase WV34_00115 ENOG4108Z6B deaminase WV34_00120 ENOG4105C6E dna polymerase iii WV34_00125 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) WV34_00130 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) WV34_00140 ENOG41067KS pro-sigma K processing WV34_00170 ENOG4105CDW Resistance protein WV34_00175 ENOG4105CXN decarboxylase WV34_00180 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) WV34_00185 ENOG4105X0R protein from nitrogen regulatory protein P-II WV34_00190 ENOG4105XVJ Protein of unknown function (DUF327) WV34_00195 ENOG4105FA2 dna polymerase iii WV34_00200 ENOG4105MA4 psp1 domain protein WV34_00210 ENOG41060K3 Methyltransferase WV34_00215 ENOG4105VC4 domain protein WV34_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WV34_00225 ENOG4105KRN Transcriptional regulator, abrb family WV34_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WV34_00235 ENOG4105F8V Hydrolase, tatD family WV34_00240 ENOG41069ER domain protein WV34_00250 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) WV34_00255 ENOG4105XFA sporulation peptidase YabG WV34_00260 ENOG4105W42 Veg protein WV34_00265 ENOG4105XEW small acid-soluble spore protein WV34_00270 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) WV34_00275 ENOG4105DFT pur operon repressor WV34_00280 ENOG4105KME endoribonuclease L-psp WV34_00285 ENOG4105K4W Could be involved in septation (By similarity) WV34_00290 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) WV34_00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WV34_00300 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) WV34_00315 ENOG4108JA2 transcriptioN-repair coupling factor WV34_00320 ENOG4108M14 stage v sporulation protein t WV34_00330 ENOG4108IY2 MazG family WV34_00335 ENOG41082I2 s4 domain protein WV34_00340 ENOG4105VYY sporulation protein yabp WV34_00355 ENOG41060GV RNA binding s1 domain protein WV34_00385 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WV34_00390 ENOG4108UGV hypoxanthine phosphoribosyltransferase WV34_00395 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WV34_00400 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) WV34_00405 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) WV34_00410 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase WV34_00415 ENOG4105C6T cysteine synthase WV34_00420 ENOG4105CRQ synthase (Component I) WV34_00425 ENOG4105DDQ anthranilate synthase WV34_00430 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 WV34_00435 ENOG4105EEI dihydropteroate synthase WV34_00440 ENOG4105KRF dihydroneopterin aldolase WV34_00445 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WV34_00455 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WV34_00460 ENOG4105CRK lysyL-tRNA synthetase WV34_00495 ENOG4108Z0C Uvrb UvrC protein WV34_00500 ENOG41066A3 ATP guanido phosphotransferase WV34_00510 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WV34_00515 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) WV34_00520 ENOG4105CTP PilT protein domain protein WV34_00525 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) WV34_00530 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) WV34_00535 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) WV34_00540 ENOG4105D7W serine acetyltransferase WV34_00550 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) WV34_00555 ENOG4105C2N RNA methyltransferase TrmH family group 3 WV34_00560 ENOG4105M0M Tetracycline resistance protein WV34_00580 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WV34_00585 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) WV34_00595 ENOG4108VZM 50s ribosomal protein L10 WV34_00600 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) WV34_00605 ENOG4107Y49 methyltransferase WV34_00610 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WV34_00615 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WV34_00620 ENOG4105XPM ribosomal protein WV34_00625 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) WV34_00630 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) WV34_00635 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) WV34_00640 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WV34_00645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase WV34_00650 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) WV34_00655 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) WV34_00660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) WV34_00665 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) WV34_00670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity WV34_00675 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) WV34_00680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) WV34_00685 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) WV34_00690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) WV34_00695 ENOG41082SA 50s ribosomal protein l29 WV34_00700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal WV34_00705 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) WV34_00715 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits WV34_00720 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) WV34_00725 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WV34_00730 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) WV34_00735 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) WV34_00740 ENOG4105VPB 50S ribosomal protein L30 WV34_00745 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) WV34_00750 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WV34_00755 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) WV34_00760 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WV34_00765 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) WV34_00775 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits WV34_00780 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) WV34_00785 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WV34_00790 ENOG4108ZT0 50S ribosomal protein l17 WV34_00795 ENOG4108JJB ABC transporter WV34_00800 ENOG4108JJB ABC transporter WV34_00805 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WV34_00810 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WV34_00815 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) WV34_00820 ENOG4108UJD 30S ribosomal protein S9 WV34_00825 ENOG4108I0C methyltransferase WV34_00840 ENOG4105D1F ATP-binding protein WV34_00855 ENOG4108NMV polysaccharide deacetylase WV34_00940 ENOG4108JPW Aminotransferase WV34_00950 ENOG4105CPQ Dehydrogenase WV34_00955 ENOG4105CHH sulfate transporter WV34_00965 ENOG4108SA1 esterase WV34_00985 ENOG410874W AraC family transcriptional regulator WV34_00990 ENOG4105EHZ conserved protein UCP016719 WV34_00995 ENOG4105D17 glycoside hydrolase, family 3 domain protein WV34_01010 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate WV34_01020 ENOG4105EWC Purine nucleoside phosphorylase WV34_01050 ENOG4105EMN RNA polymerase sigma factor WV34_01060 ENOG4105C8B TIGR00159 family WV34_01065 ENOG4107U5W ybbr family WV34_01070 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) WV34_01105 ENOG4105EWM Histidine kinase WV34_01115 ENOG4105C19 ABC transporter WV34_01130 ENOG4106K80 WV34_01140 ENOG41067MG lrgb family WV34_01150 ENOG41061AU MarR family Transcriptional regulator WV34_01165 ENOG4105BZU Histidine kinase WV34_01170 ENOG4105WH1 Two component transcriptional regulator luxr family WV34_01175 ENOG4105CJ1 ABC, transporter WV34_01185 ENOG41090VJ ABC-2 type transporter WV34_01200 ENOG4106DDH Sporulation-specific SASP protein WV34_01215 ENOG4107QTZ amino acid WV34_01225 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WV34_01230 ENOG4105CXY transporter WV34_01265 ENOG4107SCQ Iron-containing alcohol dehydrogenase WV34_01270 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR WV34_01275 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WV34_01280 ENOG4107ZTW SNARE associated Golgi WV34_01295 ENOG4105C72 UPF0176 protein WV34_01305 ENOG4105CM2 brancheD-chain amino acid aminotransferase WV34_01310 ENOG4108IQI permease WV34_01315 ENOG4108J5H Homocysteine s-methyltransferase WV34_01325 ENOG4105CSV Glutaminase WV34_01355 ENOG41076HS cation diffusion facilitator family transporter WV34_01360 ENOG4108TVJ Nitroreductase WV34_01365 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase WV34_01370 ENOG4108VGI doxx family WV34_01375 ENOG4105XXY Thioredoxin WV34_01405 ENOG4105DGI Alkaline phosphatase WV34_01410 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) WV34_01415 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WV34_01420 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) WV34_01425 ENOG4107EPV Aminotransferase class V WV34_01430 ENOG4105C0R drug resistance transporter emrb qaca subfamily WV34_01435 ENOG4105J7D transcriptional regulator WV34_01440 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold WV34_01445 ENOG41060AI SEC-C motif WV34_01450 ENOG4107SET aldo keto reductase WV34_01480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WV34_01495 ENOG4105U3E Transcriptional regulator WV34_01500 ENOG4105DSE periplasmic solute binding protein WV34_01505 ENOG4105DIK (ABC) transporter WV34_01515 ENOG4105DEN Luciferase family WV34_01525 ENOG4106FN3 tellurium resistance protein WV34_01530 ENOG4106FN3 tellurium resistance protein WV34_01535 ENOG4107TS3 membrane protein, TerC WV34_01540 ENOG4108TTB tellurium resistance protein WV34_01550 ENOG41079KZ Major Facilitator Superfamily WV34_01555 ENOG4108IJ7 Glycine betaine WV34_01560 ENOG4107SQ8 Glycine betaine WV34_01590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WV34_01620 ENOG4105EIG urea carboxylase-associated protein 1 WV34_01625 ENOG4107RA1 nh(3)-dependent nad( ) synthetase WV34_01630 ENOG4108WBH protein TIM barrel WV34_01635 ENOG4105DJB Major Facilitator Superfamily WV34_01640 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) WV34_01645 ENOG4105I82 acetyl xylan esterase WV34_01650 ENOG410756H nucleotidyltransferase WV34_01660 ENOG4105C26 Dehydrogenase WV34_01665 ENOG4105CK7 Sodium proline symporter WV34_01670 ENOG4107YHD transcriptional regulator WV34_01675 ENOG4105CAY ferredoxin--nadp reductase WV34_01680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WV34_01685 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit WV34_01690 ENOG4108IFG nitrite reductase, (NAD(P)H) WV34_01700 ENOG4105CKI cobalamin synthesis protein WV34_01705 ENOG4105E2A Dehydrogenase WV34_01710 ENOG4105HHM rdd domain containing protein WV34_01720 ENOG4105CS2 ec 3.2.1.21 WV34_01735 ENOG41080HJ 6-phospho 3-hexuloisomerase WV34_01740 ENOG4108VA3 3-hexulose-6-phosphate synthase WV34_01745 ENOG4105KVH Transcriptional regulator WV34_01755 ENOG4105CEY Amp-dependent synthetase and ligase WV34_01775 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) WV34_01790 ENOG4105CDA abc transporter atp-binding protein WV34_01795 ENOG4105DRP amino acid AbC transporter WV34_01805 ENOG4106P55 Transcriptional regulator WV34_01810 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase WV34_01815 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) WV34_01820 ENOG41069ZX WV34_01825 ENOG41069ZX WV34_01830 ENOG4105DUX Transporter WV34_01845 ENOG4105E1K spore germination protein WV34_01860 ENOG4105CPU Monooxygenase WV34_01865 ENOG4108XSB acetyltransferase, (GNAT) family WV34_01870 ENOG4105EAB amino acid AbC transporter WV34_01875 ENOG4108HW4 amino acid AbC transporter WV34_01885 ENOG4105CH2 amidohydrolase WV34_01890 ENOG4108PGP mmge prpd family protein WV34_01900 ENOG4107WD8 ABC transporter, permease WV34_01905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WV34_01910 ENOG4105BZU Histidine kinase WV34_01930 ENOG4105CFH Aspartokinase WV34_01935 ENOG4105DHS permease protein WV34_01940 ENOG4105CM4 permease protein WV34_01945 ENOG4108IPW abc transporter atp-binding protein WV34_01960 ENOG4105R8C Transcriptional regulator WV34_01965 ENOG4108DBC nitroreductase WV34_01970 ENOG41067V3 Antibiotic biosynthesis monooxygenase WV34_01975 ENOG4105YVS arsR family transcriptional regulator WV34_01985 ENOG4108JPW Aminotransferase WV34_01990 ENOG4105C26 Dehydrogenase WV34_02000 ENOG4105H9W Short-chain dehydrogenase reductase Sdr WV34_02005 ENOG4105KTB nuclear export factor GLE1 WV34_02010 ENOG4108T5E Copper resistance protein WV34_02015 ENOG4108ZYE Transcriptional regulator WV34_02035 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase WV34_02050 ENOG4105E7W lamb ycsf family protein WV34_02055 ENOG4105C5A transporter WV34_02060 ENOG4105CFM UPF0317 protein WV34_02065 ENOG4105P4J Allophanate hydrolase, subunit 1 WV34_02075 ENOG4107258 Transcriptional regulator WV34_02080 ENOG4105XJB lipolytic protein G-D-S-L family WV34_02090 ENOG41061CK Antibiotic biosynthesis monooxygenase WV34_02095 ENOG4107RVG penicillin-binding protein WV34_02100 ENOG4107QM2 Aldo Keto reductase WV34_02105 ENOG4105ETD TRANSCRIPTIONal WV34_02115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WV34_02130 ENOG410606W general stress protein WV34_02140 ENOG4105VCH membrane WV34_02150 ENOG4105C9U ATP-dependent DNA helicase RecQ WV34_02165 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) WV34_02170 ENOG4107R8N Glycosyl transferase, family 2 WV34_02180 ENOG4105C0X amino acid WV34_02230 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WV34_02240 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) WV34_02245 ENOG4105RXJ WV34_02250 ENOG4105KPY Small multidrug resistance protein WV34_02255 ENOG4105EU9 WV34_02265 ENOG41082W1 Cupin 2, conserved barrel domain protein WV34_02280 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit WV34_02285 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WV34_02290 ENOG4108MRH transcriptional regulatory protein WV34_02295 ENOG4107QJT sodium dicarboxylate symporter WV34_02300 ENOG4106F5Q Membrane WV34_02305 ENOG4105CJ1 ABC, transporter WV34_02320 ENOG4105FDT acyl-CoA dehydrogenase WV34_02335 ENOG4105SZ6 Thioredoxin WV34_02340 ENOG4105CPF Cell wall formation (By similarity) WV34_02345 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WV34_02350 ENOG4105C1J atp-dependent rna helicase WV34_02355 ENOG410905X membrane-flanked domain protein WV34_02360 ENOG4105CKV Membrane WV34_02370 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) WV34_02375 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein WV34_02380 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WV34_02390 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) WV34_02395 ENOG4107MMM Anti-sigma-factor antagonist WV34_02400 ENOG4105FUA antagonist WV34_02410 ENOG4107SGM protein serine threonine phosphatase WV34_02415 ENOG4105WN5 stage II sporulation protein WV34_02420 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) WV34_02430 ENOG41064BQ Phosphatase WV34_02440 ENOG410906U SprT-like WV34_02490 ENOG4105K56 Transcriptional regulator WV34_02500 ENOG410645S MarR family Transcriptional regulator WV34_02505 ENOG4105DCM major facilitator superfamily WV34_02510 ENOG4105D3P Mannan endo-1,4-beta-mannosidase WV34_02525 ENOG410847I Transcriptional regulator, BadM Rrf2 family WV34_02540 ENOG4105VEQ Cold shock protein WV34_02580 ENOG4107U9B transcriptional regulator WV34_02585 ENOG4105DXI Major Facilitator superfamily WV34_02590 ENOG4105IRW patatin-like phospholipase family protein WV34_02600 ENOG4105DNP FAD linked oxidase domain protein WV34_02610 ENOG4105PGM cation diffusion facilitator family transporter WV34_02625 ENOG4108U7W acetyltransferase WV34_02630 ENOG41086D8 Transcriptional regulator WV34_02660 ENOG4105DQ4 alcohol dehydrogenase WV34_02665 ENOG4105VUF Transcriptional regulator WV34_02675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WV34_02690 ENOG4105EQ0 Major Facilitator superfamily WV34_02695 ENOG4108JGH Tetr family transcriptional regulator WV34_02700 ENOG4105T38 integral membrane protein WV34_02705 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WV34_02720 ENOG4105E2A Dehydrogenase WV34_02725 ENOG4105PGS Spore coat protein WV34_02735 ENOG4108Z86 Glutamine amidotransferase WV34_02750 ENOG4108JYZ YitT family WV34_02760 ENOG4105C2C drug resistance transporter, Bcr CflA WV34_02765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WV34_02785 ENOG41090E6 transcriptional regulator MERR family WV34_02800 ENOG4105EBM Alpha Beta Hydrolase Fold protein WV34_02805 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WV34_02810 ENOG4105DRR Transcriptional regulator, GntR family WV34_02825 ENOG4105FQP Beta-lactamase WV34_02830 ENOG41090UD (LipO)protein WV34_02835 ENOG4108SUT Major Facilitator Superfamily WV34_02840 ENOG4108TZY GntR Family Transcriptional Regulator WV34_02845 ENOG4105JXH GntR family transcriptional regulator WV34_02850 ENOG4105DJ2 Major Facilitator Superfamily WV34_02870 ENOG4107QTZ amino acid WV34_02890 ENOG4107QNK )-transporter WV34_02930 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) WV34_02935 ENOG4105K8N protein family UPF0079, ATPase WV34_02940 ENOG41072GX Peptidase M22 Glycoprotease WV34_02945 ENOG410801F ribosomal-protein-alanine acetyltransferase WV34_02950 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WV34_02955 ENOG4105C5H ABC transporter WV34_02960 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WV34_02965 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) WV34_02970 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) WV34_02975 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WV34_02985 ENOG4108TYN CAAX amino terminal protease family protein WV34_02990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) WV34_02995 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) WV34_03015 ENOG41067QW Transcriptional regulator WV34_03020 ENOG4106A7E Transcriptional regulator WV34_03060 ENOG4108NF7 phage-type endonuclease WV34_03065 ENOG4108PNI recT protein WV34_03310 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WV34_03330 ENOG4105DQ6 Transposase WV34_03365 ENOG4105PGZ NB-ARC domain WV34_03370 ENOG4105CPQ Dehydrogenase WV34_03375 ENOG4105CT4 transporter WV34_03390 ENOG41087YS Phage shock protein A WV34_03395 ENOG4105DQX Zinc finger domain WV34_03400 ENOG4108WV1 Pfam:DUF477 WV34_03410 ENOG4105EXC Acyl-transferase WV34_03415 ENOG4108P49 AntiSigma factor WV34_03420 ENOG4105JVQ RNA Polymerase WV34_03450 ENOG4107STQ Multicopper oxidase WV34_03455 ENOG4105C85 amino acid WV34_03470 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WV34_03485 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WV34_03495 ENOG4107STQ Multicopper oxidase WV34_03500 ENOG410635T phage-like element pbsx protein WV34_03505 ENOG41067QW Transcriptional regulator WV34_03530 ENOG4108RYM conjugative transposon protein WV34_03535 ENOG4106BHR ftsk SpoIIIE family protein WV34_03540 ENOG4106128 DNA-binding helix-turn-helix protein WV34_03595 ENOG4105K4H Nlp p60 protein WV34_03640 ENOG4106BHR ftsk SpoIIIE family protein WV34_03645 ENOG4106128 DNA-binding helix-turn-helix protein WV34_03685 ENOG4105K4H Nlp p60 protein WV34_03700 ENOG4105C4R Atp-dependent dna helicase WV34_03715 ENOG4108J8C transporter major facilitator family protein WV34_03750 ENOG4105C7N Xanthine uracil vitamin C permease WV34_03770 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WV34_03775 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WV34_03780 ENOG4105C83 adenylosuccinate lyase WV34_03785 ENOG4105C8V SAICAR synthetase WV34_03790 ENOG4105VR9 phosphoribosylformylglycinamidine synthase WV34_03795 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I WV34_03800 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii WV34_03810 ENOG4105CXB phosphoribosylaminoimidazole synthetase WV34_03815 ENOG4108V3E phosphoribosylglycinamide formyltransferase WV34_03820 ENOG4105DC1 bifunctional purine biosynthesis protein purh WV34_03825 ENOG4105C12 Phosphoribosylglycinamide synthetase WV34_03835 ENOG4105DVH amino acid WV34_03850 ENOG4108R5T secreted protein WV34_03855 ENOG4105KGF protein, YerC YecD WV34_03860 ENOG4105CBC glutamate synthase WV34_03875 ENOG4105C4R Atp-dependent dna helicase WV34_03880 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WV34_03890 ENOG4105CRN Aminoglycoside phosphotransferase WV34_03895 ENOG4105KT7 mgtC SapB transporter WV34_03900 ENOG4105CK7 Sodium proline symporter WV34_03905 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WV34_03910 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WV34_03915 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) WV34_03920 ENOG4108IG5 Transcriptional regulator WV34_03930 ENOG4105CBD Diacylglycerol kinase WV34_03935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WV34_03945 ENOG4105CVR type I restriction-modification system WV34_03955 ENOG4105DZR Type I site-specific deoxyribonuclease WV34_03980 ENOG4105CDY transcriptional regulatory protein WV34_03990 ENOG41075D4 Aminoglycoside 6-adenylyltransferase WV34_04005 ENOG4105WEF catalase WV34_04010 ENOG4105M18 -acetyltransferase WV34_04020 ENOG4105H67 Protein of unknown function (DUF421) WV34_04025 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) WV34_04030 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WV34_04045 ENOG4106I4J membrane WV34_04050 ENOG41082F9 transcriptional regulator WV34_04055 ENOG41061H0 Monooxygenase WV34_04060 ENOG4108R1P WV34_04065 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WV34_04075 ENOG4105E0M Sulfatase WV34_04080 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WV34_04090 ENOG41090R9 glycosyltransferase WV34_04095 ENOG4107R51 Glycosyl transferase, family 2 WV34_04100 ENOG41090R9 glycosyltransferase WV34_04105 ENOG4105EU0 Major facilitator Superfamily WV34_04110 ENOG4105CUB amino acid WV34_04115 ENOG4105C26 Dehydrogenase WV34_04120 ENOG4105FKZ Methyl-accepting chemotaxis WV34_04125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WV34_04130 ENOG4107TVC Glycosyl transferase, family 2 WV34_04135 ENOG4105C5H ABC transporter WV34_04140 ENOG4107SWG transcriptional regulator MERR family WV34_04145 ENOG4105DXB Major Facilitator superfamily WV34_04150 ENOG4105C5H ABC transporter WV34_04155 ENOG4105FDU atp-dependent rna helicase WV34_04160 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein WV34_04175 ENOG4108J20 pectate lyase WV34_04180 ENOG4107QPK )-transporter WV34_04225 ENOG4108NEV two component transcriptional regulator, LytTR family WV34_04235 ENOG4108Z6X (sortase) family WV34_04245 ENOG4108MRH transcriptional regulatory protein WV34_04270 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) WV34_04275 ENOG4108RPX mosc domain containing protein WV34_04285 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) WV34_04325 ENOG4105C5Y PTS System WV34_04330 ENOG4105CG3 alpha amylase, catalytic region WV34_04335 ENOG4107414 GntR family transcriptional regulator WV34_04340 ENOG4108RCM Nitroreductase WV34_04355 ENOG4105CGH 5'-nucleotidase WV34_04360 ENOG4107RKG DJ-1/PfpI family WV34_04365 ENOG4105ETE Transcriptional regulator (LacI family WV34_04370 ENOG4105E2X shikimate dehydrogenase WV34_04375 ENOG4105FF2 Type I DHQase WV34_04390 ENOG4105KJF protein tyrosine phosphatase WV34_04400 ENOG4107U9T Pfam:Ribonuclease_BN WV34_04405 ENOG4108ISG Major Facilitator WV34_04410 ENOG4105UPD Calcium Proton WV34_04420 ENOG4105D8X mechanosensitive ion channel WV34_04440 ENOG4106KE4 Dehydrogenase WV34_04450 ENOG4105D7N magnesium and cobalt transport protein CorA WV34_04460 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WV34_04485 ENOG4105DA5 (ABC) transporter WV34_04495 ENOG4105CJ1 ABC, transporter WV34_04500 ENOG4108SDH ABC, transporter WV34_04525 ENOG4107RUY (E1 component), alpha subunit WV34_04535 ENOG4107QKR Dehydrogenase WV34_04545 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WV34_04555 ENOG4105F8D glycoside hydrolase family 4 WV34_04560 ENOG4108Q3X Transcriptional regulator WV34_04565 ENOG4105CI1 PTS System WV34_04575 ENOG4105BZ1 (ABC) transporter WV34_04580 ENOG4105BZ1 (ABC) transporter WV34_04590 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WV34_04595 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) WV34_04600 ENOG4105U3E Transcriptional regulator WV34_04605 ENOG4105DYS nad(p)h dehydrogenase (quinone) WV34_04610 ENOG4105H93 Acyltransferase family WV34_04625 ENOG4108YYS metal-dependent hydrolase (By similarity) WV34_04630 ENOG4105C0R drug resistance transporter emrb qaca subfamily WV34_04635 ENOG410834F Transcriptional regulator WV34_04645 ENOG4105JAB phenazine biosynthesis protein, phzf family WV34_04650 ENOG4107Y03 Nitroreductase WV34_04660 ENOG4105ECP epimerase WV34_04665 ENOG410902V Modulates RecA activity (By similarity) WV34_04675 ENOG4105F27 Major Facilitator WV34_04685 ENOG4108TCS Glutamyl endopeptidase WV34_04705 ENOG4106AKJ WV34_04715 ENOG4105CKK Glycosyl transferase, family 2 WV34_04720 ENOG4105EJV Membrane WV34_04725 ENOG41067AE Membrane-bound metal-dependent hydrolase WV34_04730 ENOG4105CEN a g-specific adenine glycosylase WV34_04735 ENOG4106BXE WV34_04740 ENOG4105CAN Short-chain dehydrogenase reductase Sdr WV34_04760 ENOG4105BZ1 (ABC) transporter WV34_04765 ENOG4107NBY Membrane WV34_04770 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WV34_04775 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WV34_04780 ENOG4105G5W regulator Fur family WV34_04785 ENOG4105TUA UPF0295 protein WV34_04890 ENOG4107S6Z Na H antiporter WV34_04895 ENOG4105EC3 peptidase S51, dipeptidase E WV34_04900 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) WV34_04905 ENOG4105DNP FAD linked oxidase domain protein WV34_04915 ENOG4105DEF Extracellular solute-binding protein, family 5 WV34_04925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WV34_04930 ENOG4105C3U ABC transporter WV34_04935 ENOG4108JQ7 (ABC) transporter WV34_04950 ENOG4105E2Y ABC, transporter WV34_04955 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein WV34_04960 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WV34_04975 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) WV34_04980 ENOG4107D63 WV34_04985 ENOG4105VZ8 Transcriptional regulator WV34_05000 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WV34_05010 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WV34_05030 ENOG4105CYN Serine protein kinase WV34_05040 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes WV34_05045 ENOG4105CW7 secretion protein, HlyD family WV34_05050 ENOG4105C0R drug resistance transporter emrb qaca subfamily WV34_05055 ENOG4105CS1 NAD(P)H quinone oxidoreductase WV34_05070 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WV34_05075 ENOG4105CZV ABC transporter WV34_05080 ENOG4105CJ1 ABC, transporter WV34_05085 ENOG4108TU7 Inherit from COG: (ABC) transporter WV34_05090 ENOG4105VEQ Cold shock protein WV34_05145 ENOG4108YBP pseudouridine synthase WV34_05155 ENOG41080XP Cbs domain WV34_05160 ENOG4107YBY Hydrolase WV34_05165 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase WV34_05170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WV34_05175 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WV34_05185 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) WV34_05190 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WV34_05200 ENOG4105BZU Histidine kinase WV34_05205 ENOG4105WH1 Two component transcriptional regulator luxr family WV34_05240 ENOG4105ED1 spovr family WV34_05245 ENOG4105G6Z alkaline phosphatase WV34_05260 ENOG4105BZN citrate synthase WV34_05265 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WV34_05270 ENOG4105CUB amino acid WV34_05275 ENOG4105C8J )-transporter WV34_05285 ENOG4105J37 WV34_05290 ENOG4108AEY RNA polymerase sigma factor WV34_05295 ENOG4105F6E Acyl-transferase WV34_05300 ENOG4105C37 (CBS) domain WV34_05310 ENOG4105CHM Aminotransferase WV34_05315 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase WV34_05320 ENOG4105C37 (CBS) domain WV34_05330 ENOG4105WMR Protein CrcB homolog WV34_05335 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WV34_05340 ENOG4105D64 Mechanosensitive ion channel WV34_05345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WV34_05350 ENOG4107VMI polysaccharide deacetylase WV34_05355 ENOG4105F0I Aminotransferase WV34_05360 ENOG4105W1N transcriptional regulator WV34_05365 ENOG4105IIP Membrane WV34_05375 ENOG4105BZ1 (ABC) transporter WV34_05380 ENOG4105BZ1 (ABC) transporter WV34_05405 ENOG410839P WV34_05415 ENOG4106MP8 UPF0754 membrane protein WV34_05420 ENOG4105WZB UPF0342 protein WV34_05430 ENOG4105D4P Coproporphyrinogen iii oxidase WV34_05440 ENOG4107S91 Sodium hydrogen exchanger WV34_05445 ENOG4105NCW Trka-c domain protein WV34_05455 ENOG4105CGU Enoyl-CoA hydratase WV34_05465 ENOG4108IUX (ABC) transporter WV34_05470 ENOG4105RHA ABC transporter, permease WV34_05475 ENOG4107VRP DNA repair exonuclease WV34_05480 ENOG4106D4I domain protein WV34_05485 ENOG4105EQI Metal Dependent Phosphohydrolase WV34_05495 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WV34_05540 ENOG4105NBU tryptophan transport protein WV34_05545 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WV34_05550 ENOG4105K59 histidine triad (HIT) protein WV34_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation WV34_05585 ENOG4105BZ4 penicillin-binding protein WV34_05590 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) WV34_05595 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WV34_05600 ENOG4105C1Q protoporphyrinogen oxidase WV34_05610 ENOG4105ECB domain protein WV34_05625 ENOG4105DER m42 family WV34_05635 ENOG4108RQ5 Beta-lactamase domain-containing protein WV34_05640 ENOG4105DF9 Lipoate-protein, ligase WV34_05650 ENOG4105CEY Amp-dependent synthetase and ligase WV34_05660 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 WV34_05670 ENOG4108HUF Transporter WV34_05675 ENOG4107TB6 phosphoglycerate mutase WV34_05685 ENOG4107F3J Amp-dependent synthetase and ligase WV34_05690 ENOG4107ZYJ bioY protein WV34_05695 ENOG4106YBV Methyl-accepting chemotaxis WV34_05715 ENOG4105XVF Competence transcription factor WV34_05720 ENOG4108ZMX Domain of unknown function (DU1801) WV34_05735 ENOG4105X3H Excalibur domain protein WV34_05740 ENOG4105K8R UPF0145 protein WV34_05745 ENOG4105E1V na solute symporter WV34_05750 ENOG4106CAD Protein of unknown function (DUF3311) WV34_05755 ENOG41060YP WV34_05770 ENOG4107SCK Monooxygenase WV34_05775 ENOG4108INS Transcriptional regulator WV34_05780 ENOG4108KK1 membrane protein AbrB duplication WV34_05790 ENOG4108IG5 Transcriptional regulator WV34_05800 ENOG4108QY0 Membrane WV34_05805 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination WV34_05810 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation WV34_05820 ENOG4105EYH Exonuclease WV34_05865 ENOG4105ERH Fumarylacetoacetate hydrolase WV34_05875 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WV34_05885 ENOG4105CAQ asparagine synthetase WV34_05895 ENOG4105UQX Mate efflux family protein WV34_05900 ENOG4106HBX Transcriptional Regulator AraC Family WV34_05905 ENOG4105ETE Transcriptional regulator (LacI family WV34_05910 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) WV34_05915 ENOG4105SF0 DinB family WV34_05920 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WV34_05925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WV34_05930 ENOG4105MYW Pentapeptide repeat protein WV34_05940 ENOG4105MA6 gCN5-related N-acetyltransferase WV34_05950 ENOG4108VPT UPF0234 protein WV34_05955 ENOG4105QNR S1 RNA binding domain protein WV34_05960 ENOG4105DIH basic membrane WV34_05965 ENOG4105C8Q Methyl-accepting chemotaxis WV34_05970 ENOG4107E6A Cytochrome p-450 WV34_05975 ENOG4105EPR degv family WV34_05980 ENOG4107AYK membrAne WV34_05990 ENOG41073B9 WV34_05995 ENOG4108KP7 hydrolase WV34_06000 ENOG4108MXZ Esterase WV34_06005 ENOG4105VG1 fes assembly suf system protein WV34_06010 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) WV34_06015 ENOG4105IQ5 FAD linked oxidase domain protein WV34_06025 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase WV34_06035 ENOG4105CAS nag kinase WV34_06040 ENOG4105C8Y Acetylornithine aminotransferase WV34_06045 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain WV34_06055 ENOG4105DBV ornithine carbamoyltransferase WV34_06080 ENOG4107RMD Basic membrane lipoprotein WV34_06095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WV34_06100 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WV34_06110 ENOG4105C3U ABC transporter WV34_06115 ENOG4108JQ7 (ABC) transporter WV34_06130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WV34_06140 ENOG4105C31 Tryptophanyl-tRNA synthetase WV34_06145 ENOG4108J59 Extracellular solute-binding protein, family 5 WV34_06150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WV34_06155 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WV34_06165 ENOG4108JQ7 (ABC) transporter WV34_06180 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) WV34_06185 ENOG4108ZCF integral membrane protein WV34_06190 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis WV34_06200 ENOG4105DPN Oligoendopeptidase f WV34_06210 ENOG4105T58 Dithiol-disulfide isomerase WV34_06215 ENOG4108Z18 K06886 hemoglobin WV34_06220 ENOG4105E4C Lytic transglycosylase catalytic WV34_06225 ENOG4105MIX Adenylate cyclase WV34_06240 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WV34_06245 ENOG4105EMS pseudouridine synthase WV34_06250 ENOG4107S1Q Phosphatase WV34_06260 ENOG4105ETU transcriptional activator (TenA WV34_06265 ENOG4108VEU Thiamine monophosphate synthase WV34_06285 ENOG4105D06 uba thif-type nad fad binding protein WV34_06290 ENOG4105DWF phosphomethylpyrimidine kinase WV34_06295 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH WV34_06300 ENOG4107A88 WV34_06350 ENOG4105ENA helicase WV34_06385 ENOG4108ZMI UPF0477 protein WV34_06395 ENOG4105C28 cystathionine WV34_06400 ENOG4105C28 cystathionine WV34_06505 ENOG41068SY WV34_06565 ENOG4105CK1 PTS System WV34_06570 ENOG4105VCP PTS System WV34_06575 ENOG4105CS2 ec 3.2.1.21 WV34_06580 ENOG4105E98 transcriptional regulator DeoR family WV34_06600 ENOG4105KT7 mgtC SapB transporter WV34_06615 ENOG4108IEG Formate dehydrogenase Alpha subunit WV34_06625 ENOG4106A3M Cytochrome p-450 WV34_06630 ENOG41087PP glycosyltransferase MGT family WV34_06640 ENOG4105EXQ uroporphyrinogen iii synthase hem4 WV34_06645 ENOG4105C4B ABC transporter, permease WV34_06650 ENOG4108IXI (ABC) transporter WV34_06660 ENOG4105Q95 Cupin 2, conserved barrel domain protein WV34_06675 ENOG4105D2H Uronic isomerase WV34_06680 ENOG4107KJX Transcriptional regulator WV34_06685 ENOG4105CTX dehydratase WV34_06695 ENOG4105F3H Histidine kinase WV34_06710 ENOG4107TSN permease WV34_06730 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WV34_06735 ENOG4105KWG Pfam:DUF1696 WV34_06740 ENOG4105K7W phage-related replication protein WV34_06745 ENOG410635T phage-like element pbsx protein WV34_06785 ENOG4108TFU terminase (Small subunit) WV34_06790 ENOG4105IG6 Phage terminase, large subunit WV34_06795 ENOG4108MDF Phage Portal Protein WV34_06820 ENOG41060SN WV34_06835 ENOG4105PQS phage protein WV34_06840 ENOG4105FR7 XkdM protein, phage-like element PBSX WV34_06845 ENOG4105MTC XkdN-like protein WV34_06850 ENOG4108FKH Transglycosylase SLT domain WV34_06850 ENOG4108FKH Transglycosylase SLT domain WV34_06855 ENOG4108WZM domain protein WV34_06860 ENOG4105X7F WV34_06875 ENOG41066EA baseplate J family protein WV34_06880 ENOG410906S phage-like element pbsx protein xkdt WV34_06890 ENOG41068G1 WV34_06920 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WV34_06935 ENOG4105CJ3 phosphate transporter WV34_06940 ENOG4107GRR phosphate transport regulator WV34_06945 ENOG4107R7I amino acid WV34_06955 ENOG4105EDW glycosyl transferase, family 39 WV34_06960 ENOG4105CKK Glycosyl transferase, family 2 WV34_06965 ENOG4105C0H protease WV34_06975 ENOG4108ME1 Peptidase M55 D-aminopeptidase WV34_06980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WV34_06985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WV34_06990 ENOG4105C3U ABC transporter WV34_07000 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WV34_07005 ENOG4105DTQ mandelate racemase muconate lactonizing WV34_07010 ENOG4107SN7 NLP P60 protein WV34_07015 ENOG4108JQ7 (ABC) transporter WV34_07020 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WV34_07025 ENOG4107TUM Amidinotransferase WV34_07030 ENOG4108S4H thioesterase Superfamily protein WV34_07035 ENOG4108428 Inherit from COG: -acetyltransferase WV34_07045 ENOG41080TC multidrug resistance protein WV34_07050 ENOG4105CIY formyltetrahydrofolate deformylase WV34_07055 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) WV34_07070 ENOG4105K56 Transcriptional regulator WV34_07075 ENOG4108ZHJ Organic hydroperoxide resistance protein WV34_07090 ENOG4107TVC Glycosyl transferase, family 2 WV34_07100 ENOG4105D8G Major Facilitator superfamily WV34_07105 ENOG4108Y4K DNA-binding transcriptional activator WV34_07110 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WV34_07115 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WV34_07125 ENOG4108W7F transporter, permease WV34_07130 ENOG4108JJB ABC transporter WV34_07135 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein WV34_07140 ENOG4105VRS hydrolase family 18 WV34_07145 ENOG4105CJW magnesium transporter WV34_07150 ENOG4105V75 Transcriptional regulator WV34_07170 ENOG4105DQE DNA ligase WV34_07175 ENOG4105FDF Could be involved in DNA repair (By similarity) WV34_07180 ENOG4105BZU Histidine kinase WV34_07185 ENOG4107T5V SNARE associated Golgi WV34_07190 ENOG4107TS3 membrane protein, TerC WV34_07195 ENOG4108WZW RNA polymerase sigma WV34_07205 ENOG410681C small acid-soluble spore protein WV34_07215 ENOG4105D0M Protease HtpX homolog WV34_07225 ENOG410900G Protein of unknown function (DUF421) WV34_07230 ENOG4108TGC Acyltransferase WV34_07235 ENOG4105BZU Histidine kinase WV34_07240 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WV34_07245 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) WV34_07255 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase WV34_07265 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate WV34_07270 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) WV34_07275 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) WV34_07280 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) WV34_07295 ENOG4105BZU Histidine kinase WV34_07300 ENOG41090MY MarR family Transcriptional regulator WV34_07305 ENOG4105ER2 Ompa motb domain protein WV34_07310 ENOG4105E14 MotA TolQ exbB proton channel WV34_07320 ENOG4108K88 Membrane WV34_07330 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WV34_07335 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase WV34_07340 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WV34_07345 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) WV34_07365 ENOG4105F0V Cell wall hydrolase WV34_07380 ENOG4105C59 p-type ATPase WV34_07385 ENOG4105DC7 peptidase M24 WV34_07395 ENOG4105CID antiterminator WV34_07405 ENOG4105KRI phosphocarrier protein (HPr WV34_07410 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WV34_07420 ENOG4105F6S Spore photoproduct lyase WV34_07425 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WV34_07430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WV34_07440 ENOG4105K4I Scp-like extracellular WV34_07450 ENOG4105BZU Histidine kinase WV34_07455 ENOG4105CHM Aminotransferase WV34_07460 ENOG4107R88 Chemotaxis protein (CheV) WV34_07465 ENOG4105UIN WV34_07475 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein WV34_07485 ENOG4105K6S Short-chain dehydrogenase reductase Sdr WV34_07495 ENOG4105EPM Diguanylate phosphodiesterase WV34_07500 ENOG4107IN1 Protein of unknown function (DUF1797) WV34_07505 ENOG4108XRC Protein of unknown function (DUF458) WV34_07535 ENOG4105NQC Flavodoxin WV34_07555 ENOG4105D8X mechanosensitive ion channel WV34_07565 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WV34_07580 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) WV34_07585 ENOG4105D06 uba thif-type nad fad binding protein WV34_07590 ENOG4105CVM Molybdenum cofactor synthesis domain protein WV34_07595 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein WV34_07600 ENOG4108ZAF Molybdopterin WV34_07605 ENOG41067WU Molybdopterin converting factor (Subunit 1) WV34_07615 ENOG4107X8C Efflux transporter RND family MFP subunit WV34_07620 ENOG4105C19 ABC transporter WV34_07625 ENOG4107RBB ABC transporter, permease WV34_07630 ENOG4105E98 transcriptional regulator DeoR family WV34_07635 ENOG4105DE4 1-phosphofructokinase WV34_07640 ENOG4105DM4 PTS System WV34_07655 ENOG4105C5H ABC transporter WV34_07660 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WV34_07680 ENOG4105BZU Histidine kinase WV34_07690 ENOG4107ZYR domain protein WV34_07695 ENOG4105CPN adenine deaminase WV34_07700 ENOG4105CN5 Metallo-Beta-Lactamase WV34_07705 ENOG4106148 UPF0356 protein WV34_07710 ENOG4108X4Q Hydrolase WV34_07715 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WV34_07735 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WV34_07740 ENOG4105C0W non-ribosomal peptide synthetase WV34_07745 ENOG4107SQU synthase WV34_07750 ENOG4105C0W non-ribosomal peptide synthetase WV34_07755 ENOG4107SQU synthase WV34_07760 ENOG4107SQU synthase WV34_07765 ENOG4107SQU synthase WV34_07770 ENOG4105C0W non-ribosomal peptide synthetase WV34_07775 ENOG4105FQP Beta-lactamase WV34_07785 ENOG4105CPP Dehydrogenase, E1 component WV34_07790 ENOG4105C7S Dehydrogenase WV34_07795 ENOG4107QN2 dihydrolipoyl dehydrogenase WV34_07810 ENOG4105CXN decarboxylase WV34_07815 ENOG4105WBI UPF0223 protein WV34_07830 ENOG4105ECY inositol monophosphatase WV34_07840 ENOG4105D4Y metalloprotease WV34_07875 ENOG4105CI3 gtp-binding protein typa WV34_07880 ENOG4105QA2 WV34_07895 ENOG4108IAB Phoh family WV34_07905 ENOG4105CSV Glutaminase WV34_07915 ENOG4105CNI cell division protein FtsW WV34_07920 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) WV34_07930 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) WV34_07940 ENOG4105BZ9 Cytochrome C oxidase, subunit I WV34_07945 ENOG4105CCU oxidase (Subunit III) WV34_07950 ENOG41064X9 cytochrome C oxidase subunit IV WV34_07965 ENOG41080XQ Signal transduction protein with cbs domains WV34_07970 ENOG4106UY4 Inherit from COG: Scp-like extracellular WV34_07995 ENOG4106H78 methyltransferase WV34_08000 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) WV34_08005 ENOG4105H20 Sporulation integral membrane protein YlbJ WV34_08010 ENOG4105D78 K07001 NTE family protein WV34_08015 ENOG41063PX domain protein WV34_08020 ENOG4105CDE UPF0348 protein WV34_08025 ENOG4105KNH Nucleic acid-binding protein WV34_08050 ENOG4108V6E Cell division protein mraZ WV34_08055 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) WV34_08065 ENOG4105CJN penicillin-binding protein WV34_08070 ENOG4105CJN penicillin-binding protein WV34_08075 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WV34_08080 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) WV34_08085 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) WV34_08090 ENOG4105CNI cell division protein FtsW WV34_08095 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WV34_08100 ENOG4105D4A Cell wall formation (By similarity) WV34_08105 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) WV34_08110 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WV34_08115 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WV34_08125 ENOG4105FFI sigma-e processing peptidase spoiiga WV34_08130 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_08140 ENOG4105DKW ABC transporter WV34_08150 ENOG4105WR5 sporulation protein, YlmC YmxH family WV34_08155 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WV34_08160 ENOG4105DFA alanine racemase domain protein WV34_08165 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) WV34_08170 ENOG41067XK integral membrane protein WV34_08175 ENOG4105DBK s4 domain protein WV34_08190 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WV34_08200 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) WV34_08205 ENOG4105C34 Pseudouridine synthase WV34_08210 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) WV34_08220 ENOG4105CXT aspartate transcarbamylase WV34_08230 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain WV34_08235 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain WV34_08240 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) WV34_08245 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) WV34_08250 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) WV34_08255 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WV34_08275 ENOG4107RIQ Sulfate adenylate transferase WV34_08285 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WV34_08290 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WV34_08295 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WV34_08305 ENOG4105F23 Fibronectin-binding protein WV34_08315 ENOG4105DSJ YicC domain protein WV34_08320 ENOG4105KC4 UPF0296 protein WV34_08325 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) WV34_08335 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WV34_08340 ENOG4105C25 Primosomal protein n' WV34_08345 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WV34_08350 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) WV34_08355 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WV34_08360 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs WV34_08365 ENOG4108ZF3 Phosphatase WV34_08370 ENOG4105D9P serine threonine protein kinase WV34_08375 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WV34_08380 ENOG4105DJV ribulose-phosphate 3-epimerase WV34_08385 ENOG4105FJ0 thiamine WV34_08395 ENOG4105VB9 50S ribosomal protein l28 WV34_08400 ENOG4108ZAA Alkaline-shock protein WV34_08405 ENOG4105DP4 dak2 domain fusion protein ylov WV34_08415 ENOG4105EJQ L-serine dehydratase WV34_08420 ENOG4105CB5 ATP-dependent DNA helicase recG WV34_08425 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) WV34_08430 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) WV34_08435 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WV34_08440 ENOG4105CHR reductase WV34_08445 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) WV34_08450 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) WV34_08455 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WV34_08460 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WV34_08465 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) WV34_08475 ENOG4105K5M 30s ribosomal protein S16 WV34_08480 ENOG4108BW8 UPF0109 protein WV34_08495 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) WV34_08500 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) WV34_08505 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WV34_08510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WV34_08520 ENOG4105VM1 flagellar WV34_08525 ENOG4105CMV Succinyl-CoA synthetase subunit beta WV34_08530 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WV34_08535 ENOG4105C79 DNA protecting protein DprA WV34_08540 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WV34_08545 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) WV34_08550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WV34_08555 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) WV34_08560 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) WV34_08570 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WV34_08575 ENOG4108ZC9 flagellar basal-body rod protein flgc WV34_08580 ENOG4105VQ0 flagellar hook-basal body complex protein fliE WV34_08585 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) WV34_08590 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WV34_08605 ENOG4106YF4 Flagellar biosynthesis chaperone WV34_08615 ENOG410696Y Flagellar hook-length control protein WV34_08620 ENOG410822I Flagellar hook capping protein WV34_08625 ENOG4108JQA flagellar WV34_08630 ENOG41068WV flagellar FlbD family protein WV34_08640 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WV34_08645 ENOG4105DD5 Flagellar motor switch protein WV34_08650 ENOG4107YTP response regulator receiver protein WV34_08660 ENOG4105CN7 Flagellar biosynthetic protein FliP WV34_08665 ENOG4105VS8 Flagellar biosynthetic protein fliq WV34_08670 ENOG4105D19 Role in flagellar biosynthesis (By similarity) WV34_08675 ENOG4105D00 flagellar biosynthetic protein flhB WV34_08680 ENOG4105D7B Flagellar biosynthesis protein flha WV34_08685 ENOG4105FZW flagellar biosynthesis regulator FlhF WV34_08695 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) WV34_08700 ENOG4105CBS Chea signal transduction histidine kinase WV34_08705 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis WV34_08715 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) WV34_08720 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_08730 ENOG4105CE9 30S ribosomal protein S2 WV34_08740 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WV34_08745 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) WV34_08750 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WV34_08755 ENOG4105KNE Phosphatidate cytidylyltransferase WV34_08765 ENOG4105DZP Membrane-associated zinc metalloprotease WV34_08770 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WV34_08775 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WV34_08780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) WV34_08785 ENOG4105CHV Transcription elongation factor NusA WV34_08790 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination WV34_08795 ENOG4105VHM ribosomal protein WV34_08800 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) WV34_08805 ENOG4105W7A Protein of unknown function (DUF503) WV34_08810 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) WV34_08815 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) WV34_08820 ENOG4105DTN riboflavin biosynthesis protein ribF WV34_08825 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) WV34_08830 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) WV34_08840 ENOG4105C1V Peptidase, M16 WV34_08850 ENOG4105E35 Dipicolinate synthase subunit A WV34_08855 ENOG4108S0H Dipicolinic acid synthetase, b subunit WV34_08860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WV34_08870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WV34_08880 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit WV34_08890 ENOG4105CNU cell division protein FtsK WV34_08895 ENOG4105FDP GntR family transcriptional regulator WV34_08910 ENOG4105EYF MMPL domain protein WV34_08925 ENOG4108RKS Short-chain dehydrogenase reductase Sdr WV34_08930 ENOG4105XZV Protein of unknown function (DUF3243) WV34_08945 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase WV34_08950 ENOG4105CEV competence damage-inducible protein WV34_08955 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) WV34_08960 ENOG4108A04 Beta-lactamase WV34_08970 ENOG4105D48 metallophosphoesterase WV34_08975 ENOG4105MCT stage V sporulation protein S WV34_08980 ENOG4105CPQ Dehydrogenase WV34_08985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WV34_08990 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WV34_09010 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WV34_09020 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WV34_09025 ENOG4108JA1 polyketide synthase WV34_09035 ENOG41062T2 Acyl carrier protein WV34_09040 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase WV34_09045 ENOG4108MGH Enoyl-CoA hydratase WV34_09050 ENOG4108KQ6 Enoyl-CoA hydratase WV34_09055 ENOG4105C0W non-ribosomal peptide synthetase WV34_09060 ENOG4107SQU synthase WV34_09070 ENOG4105C0W non-ribosomal peptide synthetase WV34_09080 ENOG4106A3M Cytochrome p-450 WV34_09085 ENOG4105WFK nuclease WV34_09090 ENOG4105XPP Protein of unknown function (DUF1275) WV34_09100 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WV34_09110 ENOG4105K7W phage-related replication protein WV34_09115 ENOG4108X3M OsmC Ohr family protein WV34_09140 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) WV34_09165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WV34_09170 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WV34_09175 ENOG4105U6W MutT NUDIX family protein WV34_09180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WV34_09190 ENOG4106F1P AAA ATPase, central domain protein WV34_09195 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WV34_09200 ENOG4105CXI aluminum resistance protein WV34_09205 ENOG4105KV4 Transcriptional regulator WV34_09210 ENOG4105C5F glutamine synthetase WV34_09215 ENOG4107T94 Endo-14-beta-xylanase WV34_09225 ENOG4105CT4 transporter WV34_09230 ENOG4105DSG hydrolase family 43 WV34_09240 ENOG4105C93 Xylose Isomerase WV34_09245 ENOG4105CMG Carbohydrate kinase WV34_09255 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WV34_09270 ENOG4105D29 Helix-turn-helix type 11 domain protein WV34_09280 ENOG4105DQ4 alcohol dehydrogenase WV34_09310 ENOG4105EPI acetyltransferase, (GNAT) family WV34_09345 ENOG4108M1A Chitin-binding protein WV34_09365 ENOG4105YB8 TM2 domain containing protein WV34_09370 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) WV34_09375 ENOG4105K7W phage-related replication protein WV34_09395 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) WV34_09405 ENOG4108SVB resolvase WV34_09410 ENOG4105VPS UPF0291 protein WV34_09415 ENOG4105CV1 Transketolase (EC 2.2.1.1) WV34_09425 ENOG4105VXM UPF0154 protein WV34_09470 ENOG4108I0Z Aconitate hydratase WV34_09475 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WV34_09485 ENOG41067CD Small, acid-soluble spore protein Tlp WV34_09495 ENOG4105MI2 WV34_09500 ENOG4105W8X HesB YadR YfhF-family protein WV34_09505 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WV34_09510 ENOG4105K4P CoA-binding domain protein WV34_09515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WV34_09545 ENOG4105FVX WV34_09565 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WV34_09575 ENOG4107SYN Glycosyl hydrolases family 43 WV34_09600 ENOG4105DTD Dehydrogenase WV34_09610 ENOG4105D6N CoA-transferase, subunit a WV34_09615 ENOG4106A3M Cytochrome p-450 WV34_09620 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) WV34_09625 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) WV34_09635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WV34_09650 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WV34_09655 ENOG4107T5V SNARE associated Golgi WV34_09660 ENOG4107QX3 carboxylase WV34_09665 ENOG4105E39 Enoyl-CoA hydratase WV34_09670 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WV34_09675 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit WV34_09680 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WV34_09690 ENOG4105C1G acyl-Coa dehydrogenase WV34_09695 ENOG4105F32 YngK protein WV34_09700 ENOG4106U2H Protein of unknown function (DUF1360) WV34_09710 ENOG4105CEY Amp-dependent synthetase and ligase WV34_09715 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family WV34_09720 ENOG4108N2V aldose 1-epimerase WV34_09725 ENOG4107QJQ Mate efflux family protein WV34_09800 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WV34_09805 ENOG4108RWP Major Facilitator Superfamily protein WV34_09810 ENOG4105WAB arsR family transcriptional regulator WV34_09815 ENOG4105C22 threonyL-tRNA synthetase WV34_09820 ENOG4108KSA LysR family transcriptional regulator WV34_09825 ENOG4105CB2 alcohol dehydrogenase WV34_09835 ENOG4105BZ8 glutamate synthase WV34_09840 ENOG4105CBC glutamate synthase WV34_09845 ENOG4105C5Q Transcriptional regulator WV34_09850 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) WV34_09875 ENOG4108UB7 WV34_09880 ENOG4105IE8 Alpha-ketoglutarate permease WV34_09885 ENOG4107U6E carbohydrate kinase FGGY WV34_09890 ENOG4108M3J Dehydrogenase WV34_09895 ENOG4108J2R molybdopterin oxidoreductase WV34_09925 ENOG4108Z7R Chaperone CsaA WV34_09930 ENOG4105FTV AraC Family Transcriptional Regulator WV34_09940 ENOG4108W8B Beta-lactamase domain protein WV34_09950 ENOG4105KTU Transcriptional regulator, arsr family WV34_09960 ENOG4108SJC Membrane WV34_09985 ENOG41069ER domain protein WV34_09990 ENOG4105C9U ATP-dependent DNA helicase RecQ WV34_10000 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WV34_10005 ENOG4105SCY DNAK suppressor WV34_10050 ENOG4105C26 Dehydrogenase WV34_10055 ENOG4105EWU Squalene--hopene cyclase WV34_10060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WV34_10065 ENOG4105C8J )-transporter WV34_10070 ENOG4105C09 Bile acid WV34_10080 ENOG4105C7S Dehydrogenase WV34_10085 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WV34_10090 ENOG4107T89 von Willebrand factor, type A WV34_10095 ENOG4105GMT ATPase associated with various cellular activities aaa_5 WV34_10105 ENOG4105K4H Nlp p60 protein WV34_10110 ENOG41087PP glycosyltransferase MGT family WV34_10120 ENOG4107QMU Mate efflux family protein WV34_10125 ENOG4106SCS STAS domain WV34_10145 ENOG4105FR1 rard protein WV34_10160 ENOG41090U3 tautomerase WV34_10175 ENOG4105FBA Phospholipase Carboxylesterase WV34_10190 ENOG4105E1V na solute symporter WV34_10200 ENOG4105CS2 ec 3.2.1.21 WV34_10205 ENOG4108S3Y transcriptional regulator WV34_10225 ENOG4108VXD carboxy-peptidase WV34_10230 ENOG4105D3A purine nucleoside phosphorylase DeoD-type WV34_10235 ENOG4106Z5R WV34_10240 ENOG410841Q phosphoesterase PA-phosphatase related protein WV34_10255 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WV34_10270 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein WV34_10275 ENOG4108TSC N-acetyltransferase WV34_10280 ENOG4107S4Y M20 DapE family protein YgeY WV34_10295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WV34_10305 ENOG4105FTQ Dna gyrase WV34_10345 ENOG4105C5E polysaccharide biosynthesis protein WV34_10360 ENOG4105DMF Dehydrogenase WV34_10380 ENOG4105C5E polysaccharide biosynthesis protein WV34_10385 ENOG4105E0X reductase WV34_10390 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WV34_10400 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) WV34_10405 ENOG41090WU lipolytic protein G-D-S-L family WV34_10410 ENOG4108KF3 Electron transport protein SCO1 SenC WV34_10420 ENOG4105C7B Threonine dehydratase WV34_10430 ENOG4108UT2 hemolysin iii WV34_10440 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) WV34_10445 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) WV34_10455 ENOG4107YX5 Pfam:DUF548 WV34_10460 ENOG4108Y6J UPF0403 protein WV34_10465 ENOG4105C01 Dihydroxy-acid dehydratase WV34_10480 ENOG4108V06 Glutathione peroxidase WV34_10485 ENOG4105CVG Homoserine O-transsuccinylase WV34_10525 ENOG41081VK Ribonuclease WV34_10545 ENOG410890F Dynamin family WV34_10555 ENOG41065KQ synthase WV34_10580 ENOG4105C2W permease WV34_10585 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) WV34_10590 ENOG4105CTD carboxy-peptidase WV34_10595 ENOG4105DVT helicase WV34_10605 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WV34_10610 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) WV34_10615 ENOG4108UKS UPF0398 protein WV34_10620 ENOG4107X2U Inherit from COG: Exonuclease-like protein WV34_10625 ENOG4108I5C dEAD DEAH box helicase WV34_10670 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) WV34_10675 ENOG4105BZ4 penicillin-binding protein WV34_10685 ENOG4105CSM endonuclease III WV34_10695 ENOG4105C5S asparaginyl-tRNA synthetase WV34_10700 ENOG4105CHM Aminotransferase WV34_10710 ENOG4105DVT helicase WV34_10715 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) WV34_10725 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WV34_10735 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate WV34_10740 ENOG4105CPK Glycosyl transferase (Group 1 WV34_10745 ENOG4105FJR Lmbe family WV34_10750 ENOG4108Z5K methylglyoxal synthase WV34_10755 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) WV34_10760 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase WV34_10765 ENOG4108JYZ YitT family WV34_10770 ENOG4105F0F Oxalate decarboxylase WV34_10790 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WV34_10810 ENOG41068YB TPR repeat-containing protein WV34_10815 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase WV34_10825 ENOG4105CIH Imidazole acetol-phosphate transaminase WV34_10835 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WV34_10840 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase WV34_10845 ENOG4105DK0 Indole-3-glycerol phosphate synthase WV34_10855 ENOG4105CRQ synthase (Component I) WV34_10860 ENOG4105KHN chorismate mutase WV34_10870 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WV34_10875 ENOG4105BZU Histidine kinase WV34_10880 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WV34_10885 ENOG4105EAH synthase WV34_10890 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WV34_10895 ENOG4105XXQ heptaprenyl diphosphate synthase component I WV34_10900 ENOG4105WP2 Tryptophan RNA-binding attenuator protein WV34_10905 ENOG4105EUJ GTP cyclohydrolase i WV34_10910 ENOG4105K70 DNA-binding protein WV34_10915 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) WV34_10930 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase WV34_10935 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) WV34_10950 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) WV34_10955 ENOG4105CAT Cytidine monophosphate kinase WV34_10965 ENOG4105MSI germination protein ypeb WV34_10975 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) WV34_10980 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase WV34_10995 ENOG4107RGJ metallophosphoesterase WV34_11010 ENOG4105I7S Abortive infection protein WV34_11015 ENOG4105C9U ATP-dependent DNA helicase RecQ WV34_11020 ENOG4105T7X WV34_11030 ENOG4108SAX Membrane WV34_11035 ENOG4108JQ1 Dehydrogenase WV34_11050 ENOG4105BZU Histidine kinase WV34_11055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WV34_11060 ENOG4105CRE cytochrome C WV34_11065 ENOG4107TWT Cytochrome c biogenesis protein WV34_11075 ENOG4105FE9 pseudouridine synthase WV34_11085 ENOG4108JIC nucleoside recognition domain protein WV34_11090 ENOG4105DZ1 carboxypeptidase WV34_11100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) WV34_11105 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) WV34_11120 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) WV34_11125 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WV34_11130 ENOG4108R6K riboflavin synthase, subunit alpha WV34_11155 ENOG4107ZE5 PPIases accelerate the folding of proteins WV34_11160 ENOG4105PTM secreted protein WV34_11165 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WV34_11175 ENOG4105G6R Stage v sporulation protein ae WV34_11185 ENOG4105CZ3 stage V sporulation protein ad WV34_11190 ENOG41090VF Stage v sporulation protein ac WV34_11205 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_11210 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) WV34_11215 ENOG41082AN stage II sporulation protein WV34_11220 ENOG4105DZ1 carboxypeptidase WV34_11225 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) WV34_11230 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) WV34_11235 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WV34_11245 ENOG4105I3K Ferric uptake regulator, Fur family WV34_11250 ENOG4105MZ9 stage II sporulation protein m WV34_11270 ENOG4105DFD Na H antiporter WV34_11275 ENOG4108IJ0 Aspartate ammonia-lyase WV34_11280 ENOG4105HDK L-asparaginase WV34_11285 ENOG4108IMY Transcriptional regulator WV34_11295 ENOG4108YZ4 nudix hydrolase WV34_11305 ENOG4105CPC Aldo Keto reductase WV34_11325 ENOG4106HZJ WV34_11330 ENOG4105RHY Pfam:UPF0157 WV34_11335 ENOG4108XET gCN5-related N-acetyltransferase WV34_11340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WV34_11355 ENOG4105C02 permease WV34_11360 ENOG4105CS9 pantothenic acid kinase WV34_11370 ENOG4108IXY short-chain dehydrogenase reductase WV34_11375 ENOG41069FQ Metallo-beta-lactamase superfamily WV34_11380 ENOG4105II7 pyrroline-5-carboxylate reductase WV34_11390 ENOG4107QKG PfaD family WV34_11395 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WV34_11410 ENOG4108K70 Transcriptional regulator WV34_11420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WV34_11430 ENOG410861F 50S ribosomal protein L33 WV34_11435 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) WV34_11440 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WV34_11445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) WV34_11450 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WV34_11460 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) WV34_11465 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WV34_11470 ENOG4108HNZ carboxyl transferase WV34_11475 ENOG4108ZVT methylmalonyl-coA epimerase WV34_11480 ENOG4108VZI ErfK ybiS ycfS ynhG family protein WV34_11485 ENOG4108QEG Membrane WV34_11490 ENOG4105CDA abc transporter atp-binding protein WV34_11495 ENOG4105E5Q amino acid AbC transporter WV34_11500 ENOG4108HW3 (ABC) transporter WV34_11505 ENOG4108Y6J UPF0403 protein WV34_11510 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) WV34_11515 ENOG4105C7S Dehydrogenase WV34_11520 ENOG4105CPP Dehydrogenase, E1 component WV34_11535 ENOG4105CKM Branched-chain carboxylic acid kinase WV34_11540 ENOG4107RDP Dehydrogenase WV34_11550 ENOG4108JUB Transcriptional regulator WV34_11555 ENOG4106CCJ Protein of unknown function (DUF2627) WV34_11560 ENOG4105CR4 methylisocitrate lyase WV34_11565 ENOG4105DXD 2-methylcitrate dehydratase WV34_11575 ENOG4105C1G acyl-Coa dehydrogenase WV34_11580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WV34_11590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WV34_11595 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WV34_11615 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WV34_11630 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WV34_11635 ENOG4107QQR Sporulation WV34_11640 ENOG4105S1Z Stage IV sporulation protein B WV34_11645 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WV34_11650 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) WV34_11655 ENOG4105DX0 Hemolysin A WV34_11660 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) WV34_11665 ENOG4105CTB Polyprenyl synthetase WV34_11670 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WV34_11675 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WV34_11680 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WV34_11685 ENOG4105M7K Involved in the transcription termination process (By similarity) WV34_11690 ENOG4108ZSR alkaline shock protein WV34_11695 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WV34_11715 ENOG410644B Stage III sporulation protein af WV34_11725 ENOG4105KQ4 Stage iii sporulation protein ad WV34_11730 ENOG4108CQH stage III sporulation protein AC WV34_11735 ENOG4105KR5 Stage iii sporulation protein WV34_11740 ENOG4105CD2 stage iii sporulation protein aa WV34_11750 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) WV34_11755 ENOG4105DC7 peptidase M24 WV34_11765 ENOG4105CBJ Metal-dependent enzyme WV34_11785 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) WV34_11790 ENOG4105WZW rhodanese family WV34_11795 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor WV34_11805 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) WV34_11810 ENOG4105C0D helicase WV34_11825 ENOG4108IMY Transcriptional regulator WV34_11835 ENOG4105VFR signal peptidase WV34_11895 ENOG4105C37 (CBS) domain WV34_11920 ENOG4105C5X domain protein WV34_11960 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WV34_11970 ENOG41068DG YceG-like family WV34_11975 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WV34_11980 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WV34_11985 ENOG4105E2Z phosphate ABC transporter (Permease WV34_11990 ENOG4105C8U phosphate abc transporter WV34_11995 ENOG4105CVA phosphate WV34_12000 ENOG4107RF6 penicillin-binding protein WV34_12010 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WV34_12015 ENOG4105SXS Protein of unknown function (DUF456) WV34_12030 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) WV34_12035 ENOG41063Y9 WV34_12040 ENOG4108U5J '-nucleotidase WV34_12045 ENOG4105N80 Ferric uptake regulator, Fur family WV34_12050 ENOG4108JYZ YitT family WV34_12055 ENOG41069ZM Protein of unknown function (DUF2624) WV34_12060 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) WV34_12075 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) WV34_12080 ENOG4105EGD dinuclear metal center protein, YbgI family WV34_12095 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_12100 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WV34_12105 ENOG4108UPT UPF0178 protein WV34_12110 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) WV34_12120 ENOG4105C38 Glycyl-tRNA synthetase beta subunit WV34_12125 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit WV34_12130 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) WV34_12135 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WV34_12140 ENOG4105KG3 cytidine deaminase WV34_12145 ENOG4107YR5 Diacylglycerol kinase WV34_12150 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WV34_12155 ENOG4105CTJ Metal Dependent Phosphohydrolase WV34_12160 ENOG4105C9A Phoh family WV34_12165 ENOG4105EI1 sporulation protein yqfd WV34_12170 ENOG41068P3 sporulation protein YqfC WV34_12180 ENOG4105DI5 UPF0365 protein WV34_12185 ENOG4105F7J membrane-bound serine protease WV34_12190 ENOG4105KTH gatB Yqey WV34_12205 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WV34_12210 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WV34_12215 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) WV34_12220 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WV34_12225 ENOG4105CFG Acts as a chaperone (By similarity) WV34_12230 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ WV34_12235 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) WV34_12240 ENOG4105CSA Coproporphyrinogen iii oxidase WV34_12245 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) WV34_12255 ENOG4108ZRV stage ii sporulation protein p WV34_12260 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) WV34_12265 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) WV34_12270 ENOG4105TQK DNA polymerase iii, delta' subunit WV34_12280 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 WV34_12285 ENOG4108UK2 deaminase WV34_12290 ENOG4105KQC Competence protein WV34_12300 ENOG4108D32 Methyltransferase WV34_12310 ENOG4108WF2 Metal Dependent Phosphohydrolase WV34_12315 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) WV34_12320 ENOG410812S Rna-binding protein WV34_12325 ENOG4105E2X shikimate dehydrogenase WV34_12330 ENOG4105CQW ribosome biogenesis GTPase YqeH WV34_12335 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase WV34_12355 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WV34_12360 ENOG41080BT SNARE associated Golgi WV34_12375 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_12390 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) WV34_12395 ENOG4108J8C transporter major facilitator family protein WV34_12405 ENOG4105DQF Hydrolase WV34_12410 ENOG4108HCJ Hydrolase WV34_12420 ENOG4105DG6 mannose-6-phosphate isomerase WV34_12425 ENOG4105DM4 PTS System WV34_12440 ENOG4108Z66 YbaK ebsC protein WV34_12445 ENOG4107RSM transcriptional regulator WV34_12450 ENOG4105D94 Major Facilitator Superfamily WV34_12455 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WV34_12460 ENOG41082JN Transcriptional regulator WV34_12470 ENOG4105TMB Formate nitrite transporter WV34_12475 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) WV34_12480 ENOG4108JB9 formate dehydrogenase WV34_12495 ENOG4105C28 cystathionine WV34_12525 ENOG4107XRG penicillin-binding protein WV34_12530 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WV34_12540 ENOG4105CFP Peptidase U32 WV34_12545 ENOG4105XYU peptidase (U32 family) WV34_12550 ENOG4108VQJ O-methyltransferase WV34_12555 ENOG4105HHA aminodeoxychorismate lyase WV34_12565 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) WV34_12570 ENOG4105VBH UPF0297 protein WV34_12575 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WV34_12580 ENOG4105C02 permease WV34_12585 ENOG4105CDA abc transporter atp-binding protein WV34_12590 ENOG4105CT1 (ABC) transporter WV34_12595 ENOG4105EAD ABC transporter WV34_12600 ENOG4105DRP amino acid AbC transporter WV34_12605 ENOG41060CR WV34_12615 ENOG4105C7H Helicase, RecD TraA family WV34_12625 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WV34_12630 ENOG4105C3J Cysteine desulfurase WV34_12640 ENOG4105D1H recombination factor protein RarA WV34_12645 ENOG4105CUZ uba thif-type nad fad binding protein WV34_12650 ENOG4105C9M aspartyl-trna synthetase WV34_12655 ENOG4105CUT histidyl-tRNA synthetase WV34_12665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WV34_12670 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WV34_12675 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WV34_12685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WV34_12690 ENOG41067VP Protein of unknown function (DUF1049) WV34_12695 ENOG4105NCW Trka-c domain protein WV34_12700 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WV34_12710 ENOG4105CKP Polysaccharide Biosynthesis Protein WV34_12715 ENOG4108QG2 Membrane WV34_12720 ENOG4105NAP WV34_12725 ENOG4105VIE preprotein translocase, subunit YajC WV34_12730 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) WV34_12735 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) WV34_12740 ENOG41061AI Protein of unknown function (DUF2905) WV34_12745 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) WV34_12750 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) WV34_12765 ENOG4106678 morphogenetic protein associated with SpoVID WV34_12770 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) WV34_12775 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WV34_12780 ENOG4108IYU L-aspartate oxidase WV34_12795 ENOG4105CQC Prephenate dehydratase WV34_12805 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WV34_12815 ENOG4105K46 50S ribosomal protein l27 WV34_12820 ENOG4105X36 (ribosomal) protein WV34_12825 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) WV34_12840 ENOG4107QMS site-determining protein WV34_12845 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) WV34_12850 ENOG4105YHC Rod shape-determining protein MreD WV34_12855 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WV34_12860 ENOG4105DFF Rod shape-determining protein mreb WV34_12865 ENOG4105W5Q DNA repair protein (RadC WV34_12870 ENOG4108Z03 MAF-like protein WV34_12880 ENOG4106A3R peptidase WV34_12885 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WV34_12890 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WV34_12900 ENOG4106AR7 Spore coat protein WV34_12905 ENOG41068KH stage VI sporulation protein D WV34_12910 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WV34_12915 ENOG4105D52 delta-aminolevulinic acid dehydratase WV34_12925 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WV34_12935 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) WV34_12945 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) WV34_12950 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WV34_12955 ENOG4108IUQ atp-dependent protease WV34_12960 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) WV34_12965 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation WV34_12975 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WV34_12980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WV34_12985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WV34_12995 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WV34_13000 ENOG4108ZP8 Acetolactate synthase small subunit WV34_13005 ENOG4105C7K acetolactate synthase WV34_13030 ENOG4105M59 Phosphodiesterase, mj0936 family WV34_13035 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) WV34_13040 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) WV34_13045 ENOG4108XJQ germination protein WV34_13050 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WV34_13055 ENOG41067TZ transcriptional regulator, MarR family WV34_13060 ENOG4105PFC Transcriptional regulator WV34_13070 ENOG4105E33 succinate dehydrogenase WV34_13080 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit WV34_13090 ENOG4105CFH Aspartokinase WV34_13095 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WV34_13100 ENOG4105K63 Thioredoxin WV34_13105 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) WV34_13110 ENOG4105C10 Electron transfer flavoprotein WV34_13115 ENOG4105BZJ Electron transfer flavoprotein WV34_13120 ENOG41060WC Enoyl-CoA hydratase WV34_13125 ENOG4107Z3H Transcriptional regulator, TetR family WV34_13130 ENOG4105CEY Amp-dependent synthetase and ligase WV34_13135 ENOG4108YV3 Protein of unknown function (DUF2711) WV34_13145 ENOG4105C98 muts2 protein WV34_13150 ENOG4105DCG PHP domain protein WV34_13165 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WV34_13170 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WV34_13175 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) WV34_13180 ENOG4108RWN rrna methyltransferase WV34_13185 ENOG41067MF small acid-soluble spore protein WV34_13195 ENOG4105CQB FAD linked oxidase domain protein WV34_13200 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WV34_13210 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) WV34_13215 ENOG4105DRS transport system, permease WV34_13230 ENOG4108MDK Dehydrogenase WV34_13240 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase WV34_13245 ENOG4105EF1 ribulokinase WV34_13255 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase WV34_13260 ENOG4105CN9 Peptidase m42 family protein WV34_13270 ENOG410696E Membrane WV34_13275 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) WV34_13280 ENOG4105VJV 50s ribosomal protein L35 WV34_13285 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WV34_13290 ENOG41067MG lrgb family WV34_13300 ENOG4105DY9 regulatoR WV34_13305 ENOG4108HRK Histidine kinase WV34_13310 ENOG4105U0R haloacid dehalogenase-like hydrolase WV34_13315 ENOG4105C22 threonyL-tRNA synthetase WV34_13320 ENOG4108TDW sporulation protein YtxC WV34_13345 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WV34_13350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WV34_13355 ENOG4105KVH Transcriptional regulator WV34_13360 ENOG4105F27 Major Facilitator WV34_13365 ENOG4105CV8 reductase WV34_13370 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) WV34_13380 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WV34_13385 ENOG4105C2M dna polymerase I WV34_13390 ENOG4105BZU Histidine kinase WV34_13395 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WV34_13405 ENOG4108HMX isocitrate dehydrogenase (NADP) WV34_13410 ENOG4105BZN citrate synthase WV34_13420 ENOG4108REF Sporulation integral membrane protein ytvi WV34_13425 ENOG4105FS0 cytoplasmic membrane protein WV34_13430 ENOG4105CA9 Pyruvate kinase WV34_13435 ENOG4105CTQ phosphohexokinase WV34_13440 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) WV34_13445 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) WV34_13455 ENOG4105C6K Malic enzyme WV34_13460 ENOG4105C0B DNA polymerase III (alpha subunit) WV34_13465 ENOG4105VV2 WV34_13475 ENOG4106EVM WV34_13480 ENOG4105SFS phosphoesterase RecJ domain protein WV34_13495 ENOG4105E8R UPF0173 metal-dependent hydrolase WV34_13505 ENOG4105CH7 arginosuccinase WV34_13510 ENOG4105CDH Citrulline--aspartate ligase WV34_13515 ENOG4105EPU Molybdenum cofactor synthesis domain protein WV34_13520 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WV34_13530 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WV34_13535 ENOG4105KBJ sporulation protein ytfj WV34_13545 ENOG4105VK3 rdd domain containing protein WV34_13550 ENOG4105D07 Signal peptide peptidase, SppA WV34_13555 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WV34_13560 ENOG4105EFZ amidohydrolase WV34_13575 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) WV34_13600 ENOG4105U5Y Transcriptional regulator WV34_13610 ENOG4105BZU Histidine kinase WV34_13615 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) WV34_13620 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WV34_13650 ENOG4108NGU Transcriptional regulator WV34_13655 ENOG4108UMN azlc family WV34_13665 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WV34_13675 ENOG4105F1V Acetoin utilization protein WV34_13680 ENOG4105W87 Cbs domain WV34_13685 ENOG4105DGU Histone deacetylase WV34_13690 ENOG4105ER2 Ompa motb domain protein WV34_13695 ENOG4107R0U MotA TolQ exbB proton channel WV34_13700 ENOG4105ETE Transcriptional regulator (LacI family WV34_13705 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WV34_13725 ENOG4105DFU Cell wall formation (By similarity) WV34_13735 ENOG4108VDD TRNA binding domain protein WV34_13750 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ WV34_13765 ENOG4105C6K Malic enzyme WV34_13770 ENOG4105C8F Beta-lactamase domain protein WV34_13775 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) WV34_13785 ENOG4108V15 phosphotransferase enzyme family WV34_13800 ENOG4107F58 2'-5' rna ligase WV34_13805 ENOG4105C6T cysteine synthase WV34_13810 ENOG4107QSE Dipeptidase WV34_13815 ENOG4105C7N Xanthine uracil vitamin C permease WV34_13830 ENOG4105YW5 deoR family transcriptional regulator WV34_13845 ENOG4105CBX hi0933 family WV34_13850 ENOG4105C94 Transporter WV34_13870 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component WV34_13875 ENOG4105I1K ABC transporter WV34_13890 ENOG41085GJ domain protein WV34_13895 ENOG4105C8T Leucyl-tRNA synthetase WV34_13905 ENOG4105BZU Histidine kinase WV34_13910 ENOG410605W Major Facilitator WV34_13925 ENOG4105C19 ABC transporter WV34_13930 ENOG4105EWM Histidine kinase WV34_13940 ENOG4107R34 abc transporter permease protein WV34_13945 ENOG4105C19 ABC transporter WV34_13965 ENOG4105DVE abc transporter atp-binding protein WV34_13970 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WV34_13980 ENOG4105N5T Radical SAM Protein WV34_14000 ENOG4105E8V Alpha Beta Hydrolase Fold protein WV34_14005 ENOG4108Z0R Transferase WV34_14010 ENOG4105C85 amino acid WV34_14015 ENOG4105CAQ asparagine synthetase WV34_14020 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP WV34_14025 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase WV34_14040 ENOG4105D2X ABC transporter substrate-binding protein WV34_14050 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component WV34_14065 ENOG4108RMU ferritin dps family protein WV34_14080 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) WV34_14085 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) WV34_14090 ENOG4108V2W Carbonate dehydratase WV34_14095 ENOG4105NRA 50s ribosomal protein l31 type b WV34_14110 ENOG4105DTQ mandelate racemase muconate lactonizing WV34_14115 ENOG4105CEY Amp-dependent synthetase and ligase WV34_14120 ENOG4108IPT Naphthoate synthase WV34_14125 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) WV34_14130 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WV34_14135 ENOG4105E4F Isochorismate synthase WV34_14270 ENOG4105N67 Proton-coupled thiamine transporter YuaJ WV34_14275 ENOG4105DZ6 Band 7 protein WV34_14285 ENOG4106DF1 WV34_14290 ENOG4108VNY MOSC domain protein WV34_14295 ENOG4108JB8 alcohol dehydrogenase WV34_14300 ENOG4105C26 Dehydrogenase WV34_14305 ENOG4105TRT Transcriptional regulator WV34_14320 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj WV34_14325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WV34_14360 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WV34_14370 ENOG4105EE0 oxidoreductase WV34_14375 ENOG4108Z0Z intracellular protease Pfpi family WV34_14380 ENOG4105C8Q Methyl-accepting chemotaxis WV34_14385 ENOG4105C8Q Methyl-accepting chemotaxis WV34_14390 ENOG4105C8Q Methyl-accepting chemotaxis WV34_14395 ENOG4105C8Q Methyl-accepting chemotaxis WV34_14410 ENOG4105EA8 2-Nitropropane dioxygenase WV34_14415 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme WV34_14425 ENOG4105C37 (CBS) domain WV34_14440 ENOG4107PBV potassium channel WV34_14445 ENOG4107PBV potassium channel WV34_14460 ENOG4107QYV phosphohexose isomerase WV34_14470 ENOG4105CHJ isochorismatase hydrolase WV34_14480 ENOG4107QW4 alcohol dehydrogenase WV34_14485 ENOG4105WG9 Conserved Protein WV34_14495 ENOG4105CHM Aminotransferase WV34_14500 ENOG4108ZB6 transcriptional regulator AsnC family WV34_14505 ENOG4108MUZ hydrolase WV34_14515 ENOG4105C87 Aminotransferase class I and II WV34_14520 ENOG4108HGU Histidine kinase WV34_14525 ENOG4105Y38 Kinase-associated protein B WV34_14540 ENOG4105BZ4 penicillin-binding protein WV34_14545 ENOG4105KIR Thiol-disulfide oxidoreductase dcc WV34_14560 ENOG4108MRH transcriptional regulatory protein WV34_14565 ENOG4105DIH basic membrane WV34_14570 ENOG4108JQ9 ABC transporter WV34_14575 ENOG4105UIB (ABC) transporter WV34_14590 ENOG4105D65 subunit l WV34_14595 ENOG4105HC0 Na H antiporter WV34_14600 ENOG4108ZE9 Monovalent cation H antiporter subunit C WV34_14605 ENOG4108JPZ Monovalent cation H antiporter subunit D WV34_14610 ENOG4105SC1 monovalent cation H antiporter subunit E WV34_14620 ENOG4105KJM monovalent cation h antiporter subunit g WV34_14625 ENOG4105KA0 thioesterase Superfamily protein WV34_14635 ENOG4105BZU Histidine kinase WV34_14660 ENOG4105D58 Diguanylate phosphodiesterase WV34_14665 ENOG4105DAP Nicotinate phosphoribosyltransferase WV34_14690 ENOG4105C02 permease WV34_14705 ENOG410904N short-chain dehydrogenase reductase WV34_14740 ENOG4108K8K Transcriptional regulator WV34_14745 ENOG4105DCF alanine dehydrogenase WV34_14755 ENOG4105WQT MbtH domain protein WV34_14760 ENOG4105CEY Amp-dependent synthetase and ligase WV34_14765 ENOG4105WQI isochorismatase WV34_14770 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WV34_14775 ENOG4105E4F Isochorismate synthase WV34_14780 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WV34_14785 ENOG4105NIV Esterase WV34_14805 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WV34_14815 ENOG41069ER domain protein WV34_14825 ENOG4105CEP NADH dehydrogenase WV34_14835 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) WV34_14845 ENOG4108VHC Short-chain dehydrogenase reductase Sdr WV34_14870 ENOG4105D9P serine threonine protein kinase WV34_14895 ENOG4105C4R Atp-dependent dna helicase WV34_14910 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WV34_14915 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) WV34_14925 ENOG4105ZKE UPF0349 protein WV34_14940 ENOG41083MR nifu domain-containing protein WV34_14945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein WV34_14950 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WV34_14955 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) WV34_14960 ENOG4105D6E homoserine dehydrogenase WV34_14970 ENOG4108W5N phosphatidylglycerophosphatase a WV34_14975 ENOG4105D4U had-superfamily hydrolase, subfamily iia WV34_14985 ENOG4105MMD transcriptional regulator WV34_14990 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WV34_14995 ENOG4105FAA peptidase M23 WV34_15000 ENOG4108YTE sporulation protein YunB WV34_15005 ENOG4107R8B 5'-nucleotidase WV34_15015 ENOG4105I3N Conserved Protein WV34_15025 ENOG4105CD3 dihydroorotase WV34_15030 ENOG4105G9B Transcriptional regulator WV34_15045 ENOG4105C5R Aminotransferase WV34_15055 ENOG4108K8S endonuclease I WV34_15060 ENOG4108IJ9 (ABC) transporter WV34_15065 ENOG4105FDP GntR family transcriptional regulator WV34_15070 ENOG4108KPW sugar kinase WV34_15075 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component WV34_15080 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component WV34_15085 ENOG4105XN3 extracellular solute-binding protein family 1 WV34_15090 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine WV34_15105 ENOG4105PKS Excinuclease abc c subunit domain protein WV34_15110 ENOG4107VFR oxidoreductase WV34_15145 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WV34_15165 ENOG41068G1 WV34_15175 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj WV34_15185 ENOG4108FKH Transglycosylase SLT domain WV34_15300 ENOG4105C2M dna polymerase I WV34_15350 ENOG4108IMY Transcriptional regulator WV34_15365 ENOG4105DIW FeS assembly protein SUFB WV34_15370 ENOG4108UNV SUF system FeS assembly protein, NifU family WV34_15375 ENOG4105C9B Cysteine desulfurase WV34_15380 ENOG4105JRK feS assembly protein SufD WV34_15385 ENOG4105C3K feS assembly ATPase SufC WV34_15395 ENOG4105D01 (LipO)protein WV34_15400 ENOG4108UMI ABC transporter, permease WV34_15405 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WV34_15430 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) WV34_15435 ENOG41080E8 Transcriptional regulator, Spx MgsR family WV34_15440 ENOG4105C1G acyl-Coa dehydrogenase WV34_15445 ENOG4105CHU acetyl-coa acetyltransferase WV34_15470 ENOG41067TZ transcriptional regulator, MarR family WV34_15475 ENOG4105C0R drug resistance transporter emrb qaca subfamily WV34_15480 ENOG4105MDS 4-oxalocrotonate tautomerase WV34_15490 ENOG4105E0A ABC, transporter WV34_15505 ENOG4105E1F short-chain dehydrogenase reductase WV34_15510 ENOG4105HUF DNA protection during starvation protein WV34_15515 ENOG4105C0H protease WV34_15525 ENOG4105F3H Histidine kinase WV34_15530 ENOG41067SE Tetr family transcriptional regulator WV34_15535 ENOG4105C9Q fumarate hydratase class II WV34_15560 ENOG4105WH1 Two component transcriptional regulator luxr family WV34_15565 ENOG4105ENE Histidine kinase WV34_15580 ENOG41087YS Phage shock protein A WV34_15595 ENOG4108WBT adenosyltransferase WV34_15600 ENOG4105E0A ABC, transporter WV34_15605 ENOG4105EHG Permease protein WV34_15610 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) WV34_15615 ENOG4105EWI Short-chain dehydrogenase reductase Sdr WV34_15620 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein WV34_15630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WV34_15640 ENOG4106DF4 Sigma-70, region 4 WV34_15645 ENOG4105F0F Oxalate decarboxylase WV34_15655 ENOG4105E0A ABC, transporter WV34_15660 ENOG4105EHG Permease protein WV34_15665 ENOG4105DQ5 transport system permease protein WV34_15675 ENOG4105JQZ Methyltransferase WV34_15680 ENOG4105D5Q Arginine ornithine antiporter WV34_15690 ENOG4107K5X Membrane-bound metal-dependent hydrolase WV34_15695 ENOG4107QZ2 Sulfatase WV34_15700 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family WV34_15705 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WV34_15710 ENOG4105E0C molybdate abc transporter WV34_15715 ENOG4105WH1 Two component transcriptional regulator luxr family WV34_15725 ENOG4105CJ1 ABC, transporter WV34_15735 ENOG4108KYE ABC-2 type transporter WV34_15750 ENOG4105EEQ Na H antiporter WV34_15755 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WV34_15760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WV34_15765 ENOG4105EEM helicase WV34_15770 ENOG4105EN6 Membrane WV34_15785 ENOG4107ZQN disulfide bond WV34_15790 ENOG4105C59 p-type ATPase WV34_15795 ENOG4105C59 p-type ATPase WV34_15800 ENOG410681U heavy metal transport detoxification protein WV34_15805 ENOG4105VPX protein, conserved in bacteria WV34_15810 ENOG4105D9R oxidoreductase WV34_15815 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WV34_15830 ENOG4105DEN Luciferase family WV34_15835 ENOG4105CDA abc transporter atp-binding protein WV34_15860 ENOG4108XSB acetyltransferase, (GNAT) family WV34_15865 ENOG4108KSA LysR family transcriptional regulator WV34_15870 ENOG4105EWI Short-chain dehydrogenase reductase Sdr WV34_15875 ENOG41067XF inhibitor WV34_15880 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) WV34_15885 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WV34_15895 ENOG4105XZU Preprotein translocase, subunit SecG WV34_15915 ENOG4105KVH Transcriptional regulator WV34_15940 ENOG4105DA5 (ABC) transporter WV34_15945 ENOG4105R40 Glycine betaine carnitine choline WV34_15950 ENOG4108HQR Glycine betaine WV34_15955 ENOG4105E90 ABC transporter WV34_15960 ENOG4108IJ8 ABC transporter WV34_15965 ENOG4107HG4 Transcriptional regulator WV34_15970 ENOG4105R40 Glycine betaine carnitine choline WV34_15975 ENOG4108HQR Glycine betaine WV34_15980 ENOG4105E90 ABC transporter WV34_15985 ENOG4108IJ8 ABC transporter WV34_15990 ENOG4107HG4 Transcriptional regulator WV34_15995 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein WV34_16005 ENOG4105T65 Membrane-associated protein WV34_16010 ENOG4108W0I acetyltransferase WV34_16025 ENOG4105FJR Lmbe family WV34_16045 ENOG4108IAJ Nad-dependent epimerase dehydratase WV34_16050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WV34_16055 ENOG4107QQG Dehydrogenase WV34_16060 ENOG4105IIU Aminopeptidase WV34_16065 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) WV34_16070 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WV34_16075 ENOG4105CP7 Triose-phosphate isomerase WV34_16080 ENOG4105BZA Phosphoglycerate kinase WV34_16090 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WV34_16105 ENOG4105CMD Transcriptional regulator, GntR family WV34_16110 ENOG4105DEN Luciferase family WV34_16115 ENOG4105GZI Transcriptional regulator WV34_16120 ENOG4107RT3 EamA-like transporter family WV34_16130 ENOG4106KNT transcriptional regulator WV34_16135 ENOG4105CMG Carbohydrate kinase WV34_16140 ENOG4105C6Z Gluconate WV34_16150 ENOG4107QR9 Iron-sulfur cluster binding protein WV34_16155 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WV34_16165 ENOG4105JXH GntR family transcriptional regulator WV34_16170 ENOG4105DAA L-lactate WV34_16175 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WV34_16185 ENOG4108ZPC Polysaccharide pyruvyl transferase WV34_16190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WV34_16195 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family WV34_16200 ENOG4105D3Q Sugar transferase WV34_16210 ENOG4105K64 Glycosyl transferase, family 2 WV34_16220 ENOG4107QRS glycosyltransferase group 2 family protein WV34_16225 ENOG41068W6 Capsular polysaccharide biosynthesis protein WV34_16230 ENOG4108KMV Glycosyl transferase (Group 1 WV34_16235 ENOG4105K64 Glycosyl transferase, family 2 WV34_16240 ENOG4108PQP glycosyl transferase group 1 WV34_16250 ENOG4108QV3 biosynthesis protein WV34_16255 ENOG4105HTX biosynthesis protein WV34_16265 ENOG4105EBR Carboxylesterase WV34_16275 ENOG4105NAE bifunctional deaminase-reductase domain protein WV34_16280 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) WV34_16295 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 WV34_16300 ENOG4105PY6 Phenolic acid decarboxylase WV34_16305 ENOG4105NI3 Protein of unknown function (DUF3237) WV34_16335 ENOG4108HKT sucrose-6-phosphate hydrolase WV34_16340 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) WV34_16345 ENOG4105ETE Transcriptional regulator (LacI family WV34_16350 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WV34_16355 ENOG4108KAM Transcriptional regulator WV34_16360 ENOG4105C7F AcnD-accessory protein PrpF WV34_16375 ENOG4108URH decarboxylase WV34_16380 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain WV34_16385 ENOG4105CHH sulfate transporter WV34_16390 ENOG4108V2W Carbonate dehydratase WV34_16400 ENOG4105C5I Dehydrogenase WV34_16405 ENOG4105GGE ribonuclease WV34_16410 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase WV34_16415 ENOG4105KRI phosphocarrier protein (HPr WV34_16420 ENOG4105CIE May be required for sporulation (By similarity) WV34_16425 ENOG4105CHW UPF0052 protein WV34_16430 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WV34_16435 ENOG4108Z4K mutator MutT protein WV34_16440 ENOG4105C3M thioredoxin reductase WV34_16455 ENOG4105BZU Histidine kinase WV34_16460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WV34_16465 ENOG4105BZ1 (ABC) transporter WV34_16470 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase WV34_16475 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) WV34_16480 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase WV34_16485 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WV34_16490 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WV34_16495 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WV34_16500 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WV34_16505 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) WV34_16515 ENOG4108S4C acetyltransferase WV34_16520 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WV34_16530 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) WV34_16535 ENOG4105CE4 GlcNAc 6-P deacetylase WV34_16540 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) WV34_16545 ENOG4105FDP GntR family transcriptional regulator WV34_16550 ENOG4105J7D transcriptional regulator WV34_16555 ENOG41088CQ domain protein WV34_16560 ENOG41086DT Membrane protein of unknown function WV34_16565 ENOG41067S9 phage shock protein C, PspC WV34_16570 ENOG4108PY7 WV34_16585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WV34_16590 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WV34_16605 ENOG4105MKU Transcriptional regulator WV34_16635 ENOG4105CN1 protease WV34_16640 ENOG4108M26 parallel beta-helix repeat protein WV34_16645 ENOG4105CRP Part of the ABC transporter FtsEX involved in WV34_16650 ENOG4105CAK Cell division ATP-binding protein ftsE WV34_16665 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WV34_16670 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving WV34_16675 ENOG4105MS2 ribosomal subunit Interface protein WV34_16690 ENOG4105MQ3 flagellar protein FliS WV34_16695 ENOG4107RT6 flagellar hook-associated WV34_16700 ENOG4105I03 Flagellin WV34_16705 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) WV34_16710 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) WV34_16720 ENOG4105DTJ flagellar hook-associated protein WV34_16725 ENOG4105E1Q flagellar hook-associated protein WV34_16740 ENOG4105RU3 WV34_16745 ENOG41081UC Inherit from COG: Competence protein WV34_16765 ENOG4105WH1 Two component transcriptional regulator luxr family WV34_16770 ENOG4105BZU Histidine kinase WV34_16775 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WV34_16780 ENOG4108KGH TRANSCRIPTIONal WV34_16785 ENOG4105ESV Glycosyl transferase, family 4 WV34_16790 ENOG4107EF8 Glycosyl transferase (Group 1 WV34_16805 ENOG4105QZI O-Antigen Polymerase WV34_16810 ENOG4105C6Y Udp-glucose 6-dehydrogenase WV34_16815 ENOG4107RA4 Glycosyl transferase (Group 1 WV34_16820 ENOG4105PSV Polysaccharide Biosynthesis Protein WV34_16825 ENOG4105D3Q Sugar transferase WV34_16830 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WV34_16835 ENOG4105JFG SpoIID LytB domain protein WV34_16850 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WV34_16855 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WV34_16860 ENOG4105EY8 ABC transporter WV34_16870 ENOG4107SJB teichoic acid biosynthesis WV34_16875 ENOG41088M2 Glycosyl transferase family 2 WV34_16880 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase WV34_16890 ENOG4107RZX Teichoic acid biosynthesis protein WV34_16900 ENOG4105DG6 mannose-6-phosphate isomerase WV34_16915 ENOG4108NHD germination protein WV34_16920 ENOG4108SHN Glycosyl transferase, family 2 WV34_16925 ENOG4105C54 Major Facilitator superfamily WV34_16930 ENOG4108KGH TRANSCRIPTIONal WV34_16935 ENOG4105J7I hydrolase WV34_16940 ENOG4106UBQ WV34_16945 ENOG4105K4H Nlp p60 protein WV34_16950 ENOG4105PNM synthesis protein WV34_16960 ENOG4105N98 Capsule biosynthesis protein capB WV34_16980 ENOG4105ETE Transcriptional regulator (LacI family WV34_16985 ENOG4108RVA ribokinase WV34_16990 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) WV34_16995 ENOG4105C2J ABC transporter WV34_17000 ENOG4105CNN ABC, transporter WV34_17005 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WV34_17015 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WV34_17020 ENOG4107FQX Alpha-acetolactate decarboxylase WV34_17030 ENOG4107RSM transcriptional regulator WV34_17045 ENOG4106UIA WV34_17060 ENOG4107XC4 flavin reductase domain protein, FMN-binding WV34_17070 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WV34_17080 ENOG4105CAH Chromate WV34_17085 ENOG4105FGV Chromate WV34_17125 ENOG4108XI2 Domain of unknown function (DUF1963) WV34_17130 ENOG4105C6Y Udp-glucose 6-dehydrogenase WV34_17135 ENOG4108RB3 Capsular polysaccharide biosynthesis protein WV34_17140 ENOG4107YJ4 chain length determinant protein WV34_17145 ENOG4105HTX biosynthesis protein WV34_17155 ENOG4105KBK Zinc finger, swim domain protein WV34_17160 ENOG4105C0D helicase WV34_17165 ENOG410667J hydrolase WV34_17170 ENOG4105E98 transcriptional regulator DeoR family WV34_17175 ENOG4105Z8H single-stranded DNA-binding protein WV34_17190 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) WV34_17195 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WV34_17205 ENOG4105CGA flagellar basal-body rod protein FlgG WV34_17215 ENOG4105DFF Rod shape-determining protein mreb WV34_17220 ENOG4105MT0 Sporulation transcriptional regulator spoiiid WV34_17225 ENOG4107MII Sugar-specific transcriptional regulator TrmB WV34_17230 ENOG4105CZM Major Facilitator WV34_17235 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease WV34_17240 ENOG41080V3 Major Facilitator superfamily WV34_17245 ENOG4105D3W isochorismatase WV34_17250 ENOG4105BZU Histidine kinase WV34_17260 ENOG4105CNI cell division protein FtsW WV34_17265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WV34_17275 ENOG4105FRN stage II sporulation protein WV34_17280 ENOG4107TCE N-acetyltransferase WV34_17295 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WV34_17300 ENOG4106BRK WV34_17305 ENOG4108RYK Nad-dependent epimerase dehydratase WV34_17310 ENOG4108Z40 Transcriptional regulator WV34_17315 ENOG4105CQM Urea amidohydrolase subunit alpha WV34_17320 ENOG4105KI2 Urea amidohydrolase subunit beta WV34_17325 ENOG4108YZ9 Urea amidohydrolase subunit gamma WV34_17345 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WV34_17350 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WV34_17355 ENOG4108TF4 von Willebrand factor, type A WV34_17370 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WV34_17380 ENOG4106778 Protein of unknown function (DUF1146) WV34_17390 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) WV34_17395 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) WV34_17400 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) WV34_17405 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) WV34_17410 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WV34_17425 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) WV34_17435 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) WV34_17440 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WV34_17445 ENOG4108UIC UPF0340 protein WV34_17450 ENOG4108YZG isomerase WV34_17455 ENOG4107WAU Protein tyrosine phosphatase WV34_17460 ENOG410815N Probably functions as a manganese efflux pump (By similarity) WV34_17465 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WV34_17475 ENOG4108ZXQ stage ii sporulation protein r WV34_17490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WV34_17495 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WV34_17500 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WV34_17510 ENOG4107TT2 Auxin Efflux Carrier WV34_17515 ENOG4105C6K Malic enzyme WV34_17520 ENOG4107104 thymidine kinase WV34_17525 ENOG41082DI 50s ribosomal protein l31 WV34_17530 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WV34_17535 ENOG4105CBT Fructose-1,6-bisphosphatase WV34_17540 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WV34_17550 ENOG4105D2N Aldolase WV34_17555 ENOG410812K response regulator receiver protein WV34_17565 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WV34_17575 ENOG4105DF6 Fe-S oxidoreductase WV34_17585 ENOG4105E5J UV damage endonuclease WV34_17595 ENOG4105BZ1 (ABC) transporter WV34_17600 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WV34_17610 ENOG4105R3A Nitrate reductase WV34_17615 ENOG4108IUE nitrate reductase beta subunit WV34_17635 ENOG4107V6Q Cyclic nucleotide-binding domain WV34_17645 ENOG4105C75 arginyL-tRNA synthetase WV34_17650 ENOG410684U Domain of unknown function (DUF1934) WV34_17665 ENOG4107JM4 Tetratricopeptide repeat WV34_17675 ENOG4105CYW agmatinase WV34_17680 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) WV34_17685 ENOG4105BZ4 penicillin-binding protein WV34_17695 ENOG4108XFG YwhD family WV34_17700 ENOG4108Z4T Peptidase M50 WV34_17705 ENOG41069HH 4-oxalocrotonate tautomerase WV34_17710 ENOG41067TZ transcriptional regulator, MarR family WV34_17715 ENOG4105CUB amino acid WV34_17725 ENOG4105DCI Phosphohydrolase WV34_17735 ENOG4108VCI transcription factor, rsfa family WV34_17740 ENOG4105K7K Transcriptional regulator WV34_17750 ENOG4105CJ1 ABC, transporter WV34_17755 ENOG4108TU7 Inherit from COG: (ABC) transporter WV34_17780 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) WV34_17785 ENOG4105DUM transcriptional regulator, lysR family WV34_17790 ENOG4105HMI Membrane WV34_17795 ENOG4108IJ2 phosphate acetyltransferase WV34_17800 ENOG4107JTW chlorite dismutase WV34_17810 ENOG4105CHM Aminotransferase WV34_17820 ENOG4108M32 ATP-grasp domain WV34_17835 ENOG41061WN bacilysin biosynthesis protein WV34_17840 ENOG4105FCW Major Facilitator superfamily WV34_17845 ENOG4105C2C drug resistance transporter, Bcr CflA WV34_17860 ENOG4105C26 Dehydrogenase WV34_17865 ENOG4105D82 Glutamate dehydrogenase WV34_17875 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase WV34_17880 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WV34_17885 ENOG4105C1B dTDP-glucose 4-6-dehydratase WV34_17890 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) WV34_17895 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG WV34_17900 ENOG4107TY6 Acylneuraminate cytidylyltransferase WV34_17910 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD WV34_17915 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WV34_17950 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) WV34_17955 ENOG4108RJ9 Glycosyl transferase, family 2 WV34_17960 ENOG4105DWF phosphomethylpyrimidine kinase WV34_17975 ENOG4105C5Y PTS System WV34_17990 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin WV34_17995 ENOG4105DEN Luciferase family WV34_18000 ENOG4105D29 Helix-turn-helix type 11 domain protein WV34_18005 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WV34_18020 ENOG4108DBC nitroreductase WV34_18030 ENOG4105I4A GCN5-related N-acetyltransferase WV34_18050 ENOG4105BZ9 Cytochrome C oxidase, subunit I WV34_18055 ENOG4105E2S oxidase) subunit II WV34_18060 ENOG4107BMA Transglycosylase associated protein WV34_18070 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) WV34_18075 ENOG4105WH5 Teichoic acid glycosylation protein WV34_18100 ENOG4107ZXU DSBA oxidoreductase WV34_18105 ENOG4105DBE peroxidase WV34_18110 ENOG410650H (LipO)protein WV34_18115 ENOG4107SJW iron permease, FTR1 WV34_18120 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) WV34_18125 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase WV34_18130 ENOG4105CMU LysR family (Transcriptional regulator WV34_18135 ENOG4105VAW lrga family WV34_18140 ENOG41067MG lrgb family WV34_18150 ENOG4105DR4 Methyltransferase WV34_18160 ENOG4105CK1 PTS System WV34_18165 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin WV34_18170 ENOG4105X1N Glycosyl transferase family 8 WV34_18180 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WV34_18190 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) WV34_18195 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WV34_18200 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) WV34_18205 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WV34_18210 ENOG4105CM2 brancheD-chain amino acid aminotransferase WV34_18215 ENOG4105F8D glycoside hydrolase family 4 WV34_18220 ENOG4105VCP PTS System WV34_18225 ENOG4105CK1 PTS System WV34_18230 ENOG4105VZJ PTS System WV34_18235 ENOG4105EMD TRANSCRIPTIONal WV34_18245 ENOG4105DQ5 transport system permease protein WV34_18250 ENOG4105EHG Permease protein WV34_18260 ENOG41082YX Transcriptional regulator, arsr family WV34_18265 ENOG4107R5R arsenical pump membrane protein WV34_18270 ENOG4105VZJ PTS System WV34_18275 ENOG4105VCP PTS System WV34_18280 ENOG4105CK1 PTS System WV34_18285 ENOG4105CS2 ec 3.2.1.21 WV34_18290 ENOG4105EVU fructokinase WV34_18295 ENOG4105DG6 mannose-6-phosphate isomerase WV34_18305 ENOG4105CH6 catalase WV34_18310 ENOG4107QHE Choloylglycine hydrolase WV34_18315 ENOG4105ETS cytosine purines uracil thiamine allantoin WV34_18320 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WV34_18325 ENOG4108JJ8 (ABC) transporter WV34_18330 ENOG4108JJ9 ABC, transporter WV34_18335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WV34_18340 ENOG4105C4M (Ubiquinol oxidase) subunit I WV34_18345 ENOG4105D2K citrate carrier protein WV34_18350 ENOG4107BJW polysaccharide deacetylase WV34_18365 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WV34_18375 ENOG4105CMR udp-glucose 4-epimerase WV34_18380 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WV34_18395 ENOG4105DHI Methyltransferase WV34_18420 ENOG4105CH6 catalase WV34_18425 ENOG4105D4T Citrate transporter WV34_18435 ENOG4105CID antiterminator WV34_18440 ENOG4105DEU major facilitator superfamily WV34_18445 ENOG4105C1J atp-dependent rna helicase WV34_18510 ENOG4108NR7 pectate lyase WV34_18520 ENOG4107YZX Universal stress protein WV34_18525 ENOG4105CS2 ec 3.2.1.21 WV34_18530 ENOG4105C5Y PTS System WV34_18540 ENOG4105M6F mutator MutT protein WV34_18545 ENOG4106Z5D Glycoside Hydrolase Family 43 WV34_18555 ENOG4105C84 Histidine ammonia-lyase WV34_18560 ENOG4105CGP Urocanate hydratase WV34_18565 ENOG4105CI2 imidazolone-5-propionate hydrolase WV34_18570 ENOG4107W25 arginase agmatinase formiminoglutamase WV34_18580 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WV34_18585 ENOG4105D9N nucleoside WV34_18590 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) WV34_18595 ENOG4107RHR regulatoR WV34_18600 ENOG410667J hydrolase WV34_18630 ENOG4108V5C ABC transporter WV34_18665 ENOG4105WZ4 isomerase WV34_18670 ENOG4105F0H myo-inositol catabolism protein WV34_18675 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) WV34_18685 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) WV34_18695 ENOG4105EDK PfkB domain protein WV34_18705 ENOG4105C26 Dehydrogenase WV34_18720 ENOG4105CPC Aldo Keto reductase WV34_18725 ENOG4107QNK )-transporter WV34_18730 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) WV34_18735 ENOG41061TZ Short-chain dehydrogenase reductase Sdr WV34_18740 ENOG4108S01 response regulator WV34_18745 ENOG4108ZGX Histidine kinase WV34_18750 ENOG4105ECK Fatty Acid Desaturase WV34_18755 ENOG4105ST3 Transcriptional regulator WV34_18760 ENOG4105C26 Dehydrogenase WV34_18765 ENOG4108ITS PQQ enzyme repeat WV34_18775 ENOG4105WAB arsR family transcriptional regulator WV34_18780 ENOG4105F27 Major Facilitator WV34_18785 ENOG41085PJ rdd domain containing protein WV34_18795 ENOG4105D3R alkyl hydroperoxide reductase WV34_18800 ENOG4108JU3 Alkyl hydroperoxide reductase WV34_18810 ENOG4105C85 amino acid WV34_18830 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 WV34_18835 ENOG4108XHQ (2Fe-2S)-binding domain protein WV34_18855 ENOG4105XRQ Xanthine dehydrogenase accessory factor WV34_18890 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) WV34_18900 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) WV34_18920 ENOG4107QIV Cytochrome c biogenesis protein WV34_18930 ENOG4105WQG acetyltransferase WV34_18940 ENOG41066UZ arginase EC 3.5.3.1 WV34_18945 ENOG4108IQI permease WV34_18950 ENOG4105C8Y Acetylornithine aminotransferase WV34_18955 ENOG4108JUB Transcriptional regulator WV34_18970 ENOG4105BZU Histidine kinase WV34_18975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WV34_18985 ENOG4105C0H protease WV34_18990 ENOG4105Q2H domain protein WV34_19005 ENOG4105BZU Histidine kinase WV34_19010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WV34_19050 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WV34_19055 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase WV34_19060 ENOG4105CDU Replicative dna helicase WV34_19075 ENOG4105JNK Glycosyl transferase (Group 1 WV34_19090 ENOG4105CPK Glycosyl transferase (Group 1 WV34_19110 ENOG4105BZR domain protein WV34_19115 ENOG4108XMW Membrane WV34_19130 ENOG4105KVH Transcriptional regulator WV34_19135 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase WV34_19140 ENOG4108UZ3 Transporter WV34_19145 ENOG4105EDQ levansucrase EC 2.4.1.10 WV34_19150 ENOG4108HKT sucrose-6-phosphate hydrolase WV34_19200 ENOG4108TVJ Nitroreductase WV34_19205 ENOG4105FS7 Transcriptional regulator WV34_19215 ENOG4108U05 Transcriptional regulator WV34_19220 ENOG41082BV acetyltransferase WV34_19225 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WV34_19235 ENOG4105C7Z Conserved Protein WV34_19240 ENOG4107FCW Abortive infection protein WV34_19250 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase WV34_19260 ENOG4105CGK Exodeoxyribonuclease III WV34_19265 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WV34_19275 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) WV34_19280 ENOG4108UUM single-stranded DNA-binding protein WV34_19285 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) WV34_19290 ENOG4105C3G gtp-binding protein WV34_19295 ENOG4108J2R molybdopterin oxidoreductase WV34_19300 ENOG4105VDK protein, conserved in bacteria WV34_19315 ENOG4108ZDA Sporulation protein YyaC WV34_19320 ENOG4105FA0 parb-like partition protein WV34_19325 ENOG4107QJE Chromosome Partitioning Protein WV34_19340 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WV34_19345 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WV34_19360 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)