locus-tag class description BARD7_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BARD7_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BARD7_00003 ENOG410848D S4 domain protein YaaA BARD7_00004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BARD7_00006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BARD7_00007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BARD7_00014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BARD7_00016 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BARD7_00017 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BARD7_00018 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BARD7_00019 ENOG4105BZW Glycerate kinase BARD7_00021 ENOG4105ZMH deoxynucleoside kinase BARD7_00023 ENOG4105VRS hydrolase family 18 BARD7_00024 ENOG4105GTG Isochorismatase BARD7_00025 ENOG4108Z6B deaminase BARD7_00026 ENOG4105C6E dna polymerase iii BARD7_00027 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BARD7_00028 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BARD7_00030 ENOG41067KS pro-sigma K processing BARD7_00038 ENOG4105CDW Resistance protein BARD7_00039 ENOG4105CXN decarboxylase BARD7_00040 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BARD7_00041 ENOG4105X0R protein from nitrogen regulatory protein P-II BARD7_00042 ENOG4105XVJ Protein of unknown function (DUF327) BARD7_00043 ENOG4105FA2 dna polymerase iii BARD7_00044 ENOG4105MA4 psp1 domain protein BARD7_00046 ENOG41060K3 Methyltransferase BARD7_00047 ENOG4105VC4 domain protein BARD7_00048 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BARD7_00049 ENOG4105KRN Transcriptional regulator, abrb family BARD7_00050 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BARD7_00051 ENOG4105F8V Hydrolase, tatD family BARD7_00052 ENOG41069ER domain protein BARD7_00054 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BARD7_00055 ENOG4105XFA sporulation peptidase YabG BARD7_00056 ENOG4105W42 Veg protein BARD7_00057 ENOG4105XEW small acid-soluble spore protein BARD7_00058 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BARD7_00059 ENOG4105DFT pur operon repressor BARD7_00060 ENOG4105KME endoribonuclease L-psp BARD7_00061 ENOG4105K4W Could be involved in septation (By similarity) BARD7_00062 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BARD7_00063 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BARD7_00064 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BARD7_00067 ENOG4108JA2 transcriptioN-repair coupling factor BARD7_00068 ENOG4108M14 stage v sporulation protein t BARD7_00070 ENOG4108IY2 MazG family BARD7_00071 ENOG41082I2 s4 domain protein BARD7_00072 ENOG4105VYY sporulation protein yabp BARD7_00075 ENOG41060GV RNA binding s1 domain protein BARD7_00081 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BARD7_00082 ENOG4108UGV hypoxanthine phosphoribosyltransferase BARD7_00083 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BARD7_00084 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BARD7_00085 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BARD7_00086 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BARD7_00087 ENOG4105C6T cysteine synthase BARD7_00088 ENOG4105CRQ synthase (Component I) BARD7_00089 ENOG4105DDQ anthranilate synthase BARD7_00090 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BARD7_00091 ENOG4105EEI dihydropteroate synthase BARD7_00092 ENOG4105KRF dihydroneopterin aldolase BARD7_00093 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BARD7_00095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BARD7_00096 ENOG4105CRK lysyL-tRNA synthetase BARD7_00113 ENOG4108Z0C Uvrb UvrC protein BARD7_00114 ENOG41066A3 ATP guanido phosphotransferase BARD7_00116 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BARD7_00117 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BARD7_00118 ENOG4105CTP PilT protein domain protein BARD7_00119 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BARD7_00120 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BARD7_00121 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BARD7_00122 ENOG4105D7W serine acetyltransferase BARD7_00124 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BARD7_00125 ENOG4105C2N RNA methyltransferase TrmH family group 3 BARD7_00126 ENOG4105M0M Tetracycline resistance protein BARD7_00129 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BARD7_00130 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BARD7_00132 ENOG4108VZM 50s ribosomal protein L10 BARD7_00133 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BARD7_00134 ENOG4107Y49 methyltransferase BARD7_00135 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BARD7_00136 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BARD7_00137 ENOG4105XPM ribosomal protein BARD7_00138 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BARD7_00139 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BARD7_00140 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BARD7_00141 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BARD7_00142 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BARD7_00143 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BARD7_00144 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BARD7_00145 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BARD7_00146 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BARD7_00147 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BARD7_00148 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BARD7_00149 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BARD7_00150 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BARD7_00151 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BARD7_00152 ENOG41082SA 50s ribosomal protein l29 BARD7_00153 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BARD7_00156 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BARD7_00158 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BARD7_00159 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BARD7_00160 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BARD7_00161 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BARD7_00162 ENOG4105VPB 50S ribosomal protein L30 BARD7_00163 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BARD7_00164 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BARD7_00165 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BARD7_00166 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BARD7_00167 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BARD7_00169 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BARD7_00170 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BARD7_00171 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BARD7_00172 ENOG4108ZT0 50S ribosomal protein l17 BARD7_00173 ENOG4108JJB ABC transporter BARD7_00174 ENOG4108JJB ABC transporter BARD7_00175 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BARD7_00176 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BARD7_00177 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BARD7_00178 ENOG4108UJD 30S ribosomal protein S9 BARD7_00179 ENOG4108I0C methyltransferase BARD7_00183 ENOG4105D1F ATP-binding protein BARD7_00186 ENOG4108NMV polysaccharide deacetylase BARD7_00199 ENOG4108JPW Aminotransferase BARD7_00202 ENOG4105CHH sulfate transporter BARD7_00204 ENOG4108SA1 esterase BARD7_00208 ENOG410874W AraC family transcriptional regulator BARD7_00209 ENOG4105EHZ conserved protein UCP016719 BARD7_00210 ENOG4105D17 glycoside hydrolase, family 3 domain protein BARD7_00213 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BARD7_00215 ENOG4105EWC Purine nucleoside phosphorylase BARD7_00221 ENOG4105EMN RNA polymerase sigma factor BARD7_00223 ENOG4105C8B TIGR00159 family BARD7_00224 ENOG4107U5W ybbr family BARD7_00225 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BARD7_00229 ENOG4105CJA serine threonine protein kinase BARD7_00231 ENOG4108D32 Methyltransferase BARD7_00233 ENOG41067MG lrgb family BARD7_00235 ENOG41061AU MarR family Transcriptional regulator BARD7_00238 ENOG4105BZU Histidine kinase BARD7_00239 ENOG4105WH1 Two component transcriptional regulator luxr family BARD7_00240 ENOG4105CJ1 ABC, transporter BARD7_00248 ENOG4105C0W non-ribosomal peptide synthetase BARD7_00249 ENOG4105C0W non-ribosomal peptide synthetase BARD7_00254 ENOG4106DDH Sporulation-specific SASP protein BARD7_00257 ENOG4107QTZ amino acid BARD7_00260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BARD7_00261 ENOG4105CXY transporter BARD7_00268 ENOG4107SCQ Iron-containing alcohol dehydrogenase BARD7_00269 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BARD7_00270 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BARD7_00271 ENOG4107ZTW SNARE associated Golgi BARD7_00274 ENOG4105C72 UPF0176 protein BARD7_00276 ENOG4105CM2 brancheD-chain amino acid aminotransferase BARD7_00277 ENOG4108IQI permease BARD7_00278 ENOG4108J5H Homocysteine s-methyltransferase BARD7_00280 ENOG4105CSV Glutaminase BARD7_00285 ENOG41076HS cation diffusion facilitator family transporter BARD7_00286 ENOG4108TVJ Nitroreductase BARD7_00287 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BARD7_00288 ENOG4108VGI doxx family BARD7_00289 ENOG4105XXY Thioredoxin BARD7_00292 ENOG4105DGI Alkaline phosphatase BARD7_00293 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BARD7_00294 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BARD7_00295 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BARD7_00296 ENOG4107EPV Aminotransferase class V BARD7_00297 ENOG4105C0R drug resistance transporter emrb qaca subfamily BARD7_00298 ENOG4105J7D transcriptional regulator BARD7_00299 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BARD7_00300 ENOG41060AI SEC-C motif BARD7_00301 ENOG4107SET aldo keto reductase BARD7_00308 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BARD7_00310 ENOG4105DSE periplasmic solute binding protein BARD7_00311 ENOG4105DIK (ABC) transporter BARD7_00313 ENOG4105DEN Luciferase family BARD7_00314 ENOG4108N0M stress protein BARD7_00315 ENOG4106FN3 tellurium resistance protein BARD7_00316 ENOG4106FN3 tellurium resistance protein BARD7_00317 ENOG4107TS3 membrane protein, TerC BARD7_00318 ENOG4108TTB tellurium resistance protein BARD7_00320 ENOG41079KZ Major Facilitator Superfamily BARD7_00322 ENOG4108IJ7 Glycine betaine BARD7_00323 ENOG4107SQ8 Glycine betaine BARD7_00329 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BARD7_00335 ENOG4105EIG urea carboxylase-associated protein 1 BARD7_00336 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BARD7_00337 ENOG4108WBH protein TIM barrel BARD7_00338 ENOG4105DJB Major Facilitator Superfamily BARD7_00339 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BARD7_00340 ENOG4105I82 acetyl xylan esterase BARD7_00341 ENOG410756H nucleotidyltransferase BARD7_00343 ENOG4105C26 Dehydrogenase BARD7_00344 ENOG4105CK7 Sodium proline symporter BARD7_00345 ENOG4107YHD transcriptional regulator BARD7_00346 ENOG4105CAY ferredoxin--nadp reductase BARD7_00347 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BARD7_00348 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BARD7_00349 ENOG4108IFG nitrite reductase, (NAD(P)H) BARD7_00351 ENOG4105CKI cobalamin synthesis protein BARD7_00352 ENOG4105E2A Dehydrogenase BARD7_00353 ENOG4105HHM rdd domain containing protein BARD7_00355 ENOG4105CS2 ec 3.2.1.21 BARD7_00358 ENOG41080HJ 6-phospho 3-hexuloisomerase BARD7_00359 ENOG4108VA3 3-hexulose-6-phosphate synthase BARD7_00360 ENOG4105KVH Transcriptional regulator BARD7_00361 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_00365 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BARD7_00368 ENOG4105CDA abc transporter atp-binding protein BARD7_00369 ENOG4105DRP amino acid AbC transporter BARD7_00371 ENOG4106P55 Transcriptional regulator BARD7_00372 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BARD7_00373 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BARD7_00374 ENOG41069ZX BARD7_00375 ENOG41069ZX BARD7_00376 ENOG4105DUX Transporter BARD7_00379 ENOG4105E1K spore germination protein BARD7_00382 ENOG4105CPU Monooxygenase BARD7_00383 ENOG4108XSB acetyltransferase, (GNAT) family BARD7_00384 ENOG4105EAB amino acid AbC transporter BARD7_00385 ENOG4108HW4 amino acid AbC transporter BARD7_00387 ENOG4105CH2 amidohydrolase BARD7_00388 ENOG4108PGP mmge prpd family protein BARD7_00390 ENOG4107WD8 ABC transporter, permease BARD7_00391 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_00392 ENOG4105BZU Histidine kinase BARD7_00396 ENOG4105CFH Aspartokinase BARD7_00397 ENOG4105DHS permease protein BARD7_00398 ENOG4105CM4 permease protein BARD7_00399 ENOG4108IPW abc transporter atp-binding protein BARD7_00402 ENOG4105R8C Transcriptional regulator BARD7_00403 ENOG4108DBC nitroreductase BARD7_00404 ENOG41067V3 Antibiotic biosynthesis monooxygenase BARD7_00405 ENOG4105YVS arsR family transcriptional regulator BARD7_00407 ENOG4108JPW Aminotransferase BARD7_00408 ENOG4105C26 Dehydrogenase BARD7_00410 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BARD7_00411 ENOG4105KTB nuclear export factor GLE1 BARD7_00412 ENOG4108T5E Copper resistance protein BARD7_00413 ENOG4108ZYE Transcriptional regulator BARD7_00417 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BARD7_00421 ENOG4105E7W lamb ycsf family protein BARD7_00422 ENOG4105C5A transporter BARD7_00423 ENOG4105CFM UPF0317 protein BARD7_00424 ENOG4105P4J Allophanate hydrolase, subunit 1 BARD7_00426 ENOG4107258 Transcriptional regulator BARD7_00427 ENOG4105XJB lipolytic protein G-D-S-L family BARD7_00429 ENOG4107RVG penicillin-binding protein BARD7_00430 ENOG4107QM2 Aldo Keto reductase BARD7_00431 ENOG4105ETD TRANSCRIPTIONal BARD7_00433 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BARD7_00436 ENOG410606W general stress protein BARD7_00438 ENOG4105VCH membrane BARD7_00440 ENOG4105C9U ATP-dependent DNA helicase RecQ BARD7_00443 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BARD7_00444 ENOG4107R8N Glycosyl transferase, family 2 BARD7_00446 ENOG4105C0X amino acid BARD7_00452 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BARD7_00455 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BARD7_00456 ENOG4105EU9 BARD7_00457 ENOG4105QVS general stress protein BARD7_00461 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BARD7_00462 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BARD7_00463 ENOG4108MRH transcriptional regulatory protein BARD7_00464 ENOG4107QJT sodium dicarboxylate symporter BARD7_00465 ENOG4106F5Q Membrane BARD7_00466 ENOG4105CJ1 ABC, transporter BARD7_00469 ENOG4105FDT acyl-CoA dehydrogenase BARD7_00473 ENOG4105SZ6 Thioredoxin BARD7_00474 ENOG4105CPF Cell wall formation (By similarity) BARD7_00475 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BARD7_00476 ENOG4105C1J atp-dependent rna helicase BARD7_00477 ENOG410905X membrane-flanked domain protein BARD7_00478 ENOG4105CKV Membrane BARD7_00480 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BARD7_00481 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BARD7_00482 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BARD7_00484 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BARD7_00485 ENOG4107MMM Anti-sigma-factor antagonist BARD7_00486 ENOG4105FUA antagonist BARD7_00487 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BARD7_00488 ENOG4107SGM protein serine threonine phosphatase BARD7_00489 ENOG4105WN5 stage II sporulation protein BARD7_00490 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BARD7_00492 ENOG41064BQ Phosphatase BARD7_00495 ENOG410906U SprT-like BARD7_00505 ENOG4105VEQ Cold shock protein BARD7_00506 ENOG4108VJ1 Transcriptional regulator (CarD family BARD7_00507 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BARD7_00508 ENOG410847I Transcriptional regulator, BadM Rrf2 family BARD7_00510 ENOG4105VEQ Cold shock protein BARD7_00511 ENOG4105CPN adenine deaminase BARD7_00514 ENOG4107U9B transcriptional regulator BARD7_00515 ENOG4105DXI Major Facilitator superfamily BARD7_00516 ENOG4105IRW patatin-like phospholipase family protein BARD7_00519 ENOG4105PGM cation diffusion facilitator family transporter BARD7_00523 ENOG4108U7W acetyltransferase BARD7_00524 ENOG41086D8 Transcriptional regulator BARD7_00528 ENOG4105DQ4 alcohol dehydrogenase BARD7_00529 ENOG4105VUF Transcriptional regulator BARD7_00531 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BARD7_00534 ENOG4105T38 integral membrane protein BARD7_00535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BARD7_00538 ENOG4105E2A Dehydrogenase BARD7_00539 ENOG4105PGS Spore coat protein BARD7_00544 ENOG4108JYZ YitT family BARD7_00546 ENOG4105C2C drug resistance transporter, Bcr CflA BARD7_00547 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BARD7_00548 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BARD7_00552 ENOG41090E6 transcriptional regulator MERR family BARD7_00555 ENOG4105EBM Alpha Beta Hydrolase Fold protein BARD7_00556 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BARD7_00557 ENOG4105DRR Transcriptional regulator, GntR family BARD7_00560 ENOG4105FQP Beta-lactamase BARD7_00562 ENOG41090UD (LipO)protein BARD7_00563 ENOG4108SUT Major Facilitator Superfamily BARD7_00564 ENOG4108TZY GntR Family Transcriptional Regulator BARD7_00565 ENOG4105JXH GntR family transcriptional regulator BARD7_00566 ENOG4105DJ2 Major Facilitator Superfamily BARD7_00570 ENOG4107QTZ amino acid BARD7_00574 ENOG4107QNK )-transporter BARD7_00582 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BARD7_00583 ENOG4105K8N protein family UPF0079, ATPase BARD7_00584 ENOG41072GX Peptidase M22 Glycoprotease BARD7_00585 ENOG410801F ribosomal-protein-alanine acetyltransferase BARD7_00586 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BARD7_00587 ENOG4105C5H ABC transporter BARD7_00588 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BARD7_00589 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BARD7_00590 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BARD7_00591 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BARD7_00593 ENOG4108TYN CAAX amino terminal protease family protein BARD7_00594 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BARD7_00595 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BARD7_00596 ENOG4107QJE Chromosome Partitioning Protein BARD7_00599 ENOG4105PGZ NB-ARC domain BARD7_00600 ENOG4105CPQ Dehydrogenase BARD7_00601 ENOG4105CT4 transporter BARD7_00604 ENOG41087YS Phage shock protein A BARD7_00605 ENOG4105DQX Zinc finger domain BARD7_00606 ENOG4108WV1 Pfam:DUF477 BARD7_00608 ENOG4105EXC Acyl-transferase BARD7_00609 ENOG4108P49 AntiSigma factor BARD7_00610 ENOG4105JVQ RNA Polymerase BARD7_00616 ENOG4107STQ Multicopper oxidase BARD7_00617 ENOG4105C85 amino acid BARD7_00619 ENOG4105C5S asparaginyl-tRNA synthetase BARD7_00622 ENOG4105CPF Cell wall formation (By similarity) BARD7_00623 ENOG4106IBS oxygenase BARD7_00627 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BARD7_00630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BARD7_00631 ENOG4107RSM transcriptional regulator BARD7_00635 ENOG4105C7N Xanthine uracil vitamin C permease BARD7_00640 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BARD7_00641 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BARD7_00642 ENOG4105C83 adenylosuccinate lyase BARD7_00643 ENOG4105C8V SAICAR synthetase BARD7_00644 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BARD7_00645 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BARD7_00646 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BARD7_00648 ENOG4105CXB phosphoribosylaminoimidazole synthetase BARD7_00649 ENOG4108V3E phosphoribosylglycinamide formyltransferase BARD7_00650 ENOG4105DC1 bifunctional purine biosynthesis protein purh BARD7_00651 ENOG4105C12 Phosphoribosylglycinamide synthetase BARD7_00653 ENOG4105DVH amino acid BARD7_00656 ENOG4108R5T secreted protein BARD7_00657 ENOG4105KGF protein, YerC YecD BARD7_00658 ENOG4105CBC glutamate synthase BARD7_00660 ENOG4105C4R Atp-dependent dna helicase BARD7_00661 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BARD7_00663 ENOG4105CRN Aminoglycoside phosphotransferase BARD7_00664 ENOG4105KT7 mgtC SapB transporter BARD7_00665 ENOG4105CK7 Sodium proline symporter BARD7_00666 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BARD7_00667 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BARD7_00668 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BARD7_00669 ENOG4108IG5 Transcriptional regulator BARD7_00671 ENOG4105CBD Diacylglycerol kinase BARD7_00672 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BARD7_00680 ENOG4105CDY transcriptional regulatory protein BARD7_00682 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BARD7_00685 ENOG4105WEF catalase BARD7_00686 ENOG4105M18 -acetyltransferase BARD7_00688 ENOG4105H67 Protein of unknown function (DUF421) BARD7_00689 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BARD7_00690 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BARD7_00694 ENOG4106I4J membrane BARD7_00695 ENOG4108R1P BARD7_00696 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BARD7_00697 ENOG4105E0M Sulfatase BARD7_00698 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BARD7_00700 ENOG41090R9 glycosyltransferase BARD7_00701 ENOG4107R51 Glycosyl transferase, family 2 BARD7_00702 ENOG41090R9 glycosyltransferase BARD7_00703 ENOG4105EU0 Major facilitator Superfamily BARD7_00704 ENOG4105CUB amino acid BARD7_00705 ENOG4105C26 Dehydrogenase BARD7_00706 ENOG4105FKZ Methyl-accepting chemotaxis BARD7_00707 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BARD7_00708 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BARD7_00709 ENOG4107TVC Glycosyl transferase, family 2 BARD7_00710 ENOG4105C5H ABC transporter BARD7_00712 ENOG4107SWG transcriptional regulator MERR family BARD7_00713 ENOG4105DXB Major Facilitator superfamily BARD7_00714 ENOG4105C5H ABC transporter BARD7_00715 ENOG4105FDU atp-dependent rna helicase BARD7_00716 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BARD7_00719 ENOG4108J20 pectate lyase BARD7_00720 ENOG4107QPK )-transporter BARD7_00722 ENOG4108NEV two component transcriptional regulator, LytTR family BARD7_00724 ENOG4108Z6X (sortase) family BARD7_00726 ENOG4108MRH transcriptional regulatory protein BARD7_00732 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BARD7_00733 ENOG4108RPX mosc domain containing protein BARD7_00737 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BARD7_00745 ENOG4105C5Y PTS System BARD7_00746 ENOG4105CG3 alpha amylase, catalytic region BARD7_00747 ENOG4107414 GntR family transcriptional regulator BARD7_00748 ENOG4108RCM Nitroreductase BARD7_00751 ENOG4105CGH 5'-nucleotidase BARD7_00752 ENOG4107RKG DJ-1/PfpI family BARD7_00753 ENOG4105ETE Transcriptional regulator (LacI family BARD7_00754 ENOG4105E2X shikimate dehydrogenase BARD7_00755 ENOG4105FF2 Type I DHQase BARD7_00758 ENOG4105KJF protein tyrosine phosphatase BARD7_00760 ENOG4107U9T Pfam:Ribonuclease_BN BARD7_00761 ENOG4108ISG Major Facilitator BARD7_00762 ENOG4105UPD Calcium Proton BARD7_00764 ENOG4105D8X mechanosensitive ion channel BARD7_00768 ENOG4106KE4 Dehydrogenase BARD7_00770 ENOG4105D7N magnesium and cobalt transport protein CorA BARD7_00773 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BARD7_00777 ENOG4107RUY (E1 component), alpha subunit BARD7_00779 ENOG4107QKR Dehydrogenase BARD7_00781 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BARD7_00783 ENOG4105F8D glycoside hydrolase family 4 BARD7_00784 ENOG4108Q3X Transcriptional regulator BARD7_00785 ENOG4105CI1 PTS System BARD7_00787 ENOG4105BZ1 (ABC) transporter BARD7_00788 ENOG4105BZ1 (ABC) transporter BARD7_00790 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BARD7_00791 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BARD7_00792 ENOG4105U3E Transcriptional regulator BARD7_00793 ENOG4105DYS nad(p)h dehydrogenase (quinone) BARD7_00794 ENOG4105H93 Acyltransferase family BARD7_00796 ENOG4108YYS metal-dependent hydrolase (By similarity) BARD7_00797 ENOG4105C0R drug resistance transporter emrb qaca subfamily BARD7_00798 ENOG410834F Transcriptional regulator BARD7_00800 ENOG4105JAB phenazine biosynthesis protein, phzf family BARD7_00801 ENOG4107Y03 Nitroreductase BARD7_00804 ENOG4105ECP epimerase BARD7_00805 ENOG410902V Modulates RecA activity (By similarity) BARD7_00807 ENOG4105F27 Major Facilitator BARD7_00809 ENOG4108TCS Glutamyl endopeptidase BARD7_00812 ENOG4106AKJ BARD7_00813 ENOG4105D74 hydrolase BARD7_00814 ENOG4105CKK Glycosyl transferase, family 2 BARD7_00815 ENOG4105EJV Membrane BARD7_00816 ENOG41067AE Membrane-bound metal-dependent hydrolase BARD7_00817 ENOG4105CEN a g-specific adenine glycosylase BARD7_00818 ENOG4106BXE BARD7_00819 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BARD7_00823 ENOG4105BZ1 (ABC) transporter BARD7_00824 ENOG4107NBY Membrane BARD7_00825 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BARD7_00826 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BARD7_00827 ENOG4105G5W regulator Fur family BARD7_00828 ENOG4105TUA UPF0295 protein BARD7_00849 ENOG4107S6Z Na H antiporter BARD7_00850 ENOG4105EC3 peptidase S51, dipeptidase E BARD7_00851 ENOG4105EC3 peptidase S51, dipeptidase E BARD7_00852 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BARD7_00853 ENOG4105DNP FAD linked oxidase domain protein BARD7_00855 ENOG4105DEF Extracellular solute-binding protein, family 5 BARD7_00857 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BARD7_00858 ENOG4105C3U ABC transporter BARD7_00859 ENOG4108JQ7 (ABC) transporter BARD7_00862 ENOG4105E2Y ABC, transporter BARD7_00863 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BARD7_00864 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BARD7_00868 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BARD7_00869 ENOG4107D63 BARD7_00870 ENOG4105VZ8 Transcriptional regulator BARD7_00873 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BARD7_00875 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BARD7_00880 ENOG4105CYN Serine protein kinase BARD7_00882 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BARD7_00883 ENOG4105CW7 secretion protein, HlyD family BARD7_00884 ENOG4105C0R drug resistance transporter emrb qaca subfamily BARD7_00885 ENOG4105CS1 NAD(P)H quinone oxidoreductase BARD7_00888 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BARD7_00889 ENOG4105CZV ABC transporter BARD7_00890 ENOG4105CJ1 ABC, transporter BARD7_00891 ENOG4108TU7 Inherit from COG: (ABC) transporter BARD7_00892 ENOG4105VEQ Cold shock protein BARD7_00894 ENOG4105BZU Histidine kinase BARD7_00902 ENOG4108YBP pseudouridine synthase BARD7_00904 ENOG41080XP Cbs domain BARD7_00905 ENOG4107YBY Hydrolase BARD7_00906 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BARD7_00907 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BARD7_00908 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BARD7_00910 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BARD7_00911 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BARD7_00913 ENOG4105BZU Histidine kinase BARD7_00914 ENOG4105WH1 Two component transcriptional regulator luxr family BARD7_00921 ENOG4105ED1 spovr family BARD7_00922 ENOG4105G6Z alkaline phosphatase BARD7_00925 ENOG4105BZN citrate synthase BARD7_00926 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BARD7_00927 ENOG4105CUB amino acid BARD7_00928 ENOG4105C8J )-transporter BARD7_00930 ENOG4105J37 BARD7_00931 ENOG4108AEY RNA polymerase sigma factor BARD7_00932 ENOG4105F6E Acyl-transferase BARD7_00933 ENOG4105C37 (CBS) domain BARD7_00935 ENOG4105CHM Aminotransferase BARD7_00936 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BARD7_00937 ENOG4105C37 (CBS) domain BARD7_00939 ENOG4105WMR Protein CrcB homolog BARD7_00940 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BARD7_00942 ENOG4105D64 Mechanosensitive ion channel BARD7_00943 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BARD7_00944 ENOG4107VMI polysaccharide deacetylase BARD7_00945 ENOG4105F0I Aminotransferase BARD7_00946 ENOG4105W1N transcriptional regulator BARD7_00947 ENOG4105IIP Membrane BARD7_00949 ENOG4105BZ1 (ABC) transporter BARD7_00950 ENOG4105BZ1 (ABC) transporter BARD7_00955 ENOG410839P BARD7_00957 ENOG4106MP8 UPF0754 membrane protein BARD7_00958 ENOG4105WZB UPF0342 protein BARD7_00960 ENOG4105D4P Coproporphyrinogen iii oxidase BARD7_00962 ENOG4107S91 Sodium hydrogen exchanger BARD7_00963 ENOG4105NCW Trka-c domain protein BARD7_00965 ENOG4105CGU Enoyl-CoA hydratase BARD7_00967 ENOG4108IUX (ABC) transporter BARD7_00968 ENOG4105RHA ABC transporter, permease BARD7_00969 ENOG4107VRP DNA repair exonuclease BARD7_00970 ENOG4106D4I domain protein BARD7_00971 ENOG4105EQI Metal Dependent Phosphohydrolase BARD7_00973 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BARD7_00979 ENOG4105NBU tryptophan transport protein BARD7_00980 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BARD7_00981 ENOG4105K59 histidine triad (HIT) protein BARD7_00987 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BARD7_00988 ENOG4105BZ4 penicillin-binding protein BARD7_00989 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BARD7_00990 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BARD7_00991 ENOG4105C1Q protoporphyrinogen oxidase BARD7_00993 ENOG4105ECB domain protein BARD7_00996 ENOG4105DER m42 family BARD7_00998 ENOG4108RQ5 Beta-lactamase domain-containing protein BARD7_00999 ENOG4105DF9 Lipoate-protein, ligase BARD7_01001 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_01003 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BARD7_01005 ENOG4108HUF Transporter BARD7_01006 ENOG4107TB6 phosphoglycerate mutase BARD7_01008 ENOG4107F3J Amp-dependent synthetase and ligase BARD7_01009 ENOG4107ZYJ bioY protein BARD7_01010 ENOG4106YBV Methyl-accepting chemotaxis BARD7_01014 ENOG4105XVF Competence transcription factor BARD7_01015 ENOG4108ZMX Domain of unknown function (DU1801) BARD7_01018 ENOG4105X3H Excalibur domain protein BARD7_01019 ENOG4105K8R UPF0145 protein BARD7_01020 ENOG4105E1V na solute symporter BARD7_01021 ENOG4106CAD Protein of unknown function (DUF3311) BARD7_01022 ENOG41060YP BARD7_01026 ENOG4107SCK Monooxygenase BARD7_01027 ENOG4108INS Transcriptional regulator BARD7_01028 ENOG4108KK1 membrane protein AbrB duplication BARD7_01030 ENOG4108IG5 Transcriptional regulator BARD7_01032 ENOG4108QY0 Membrane BARD7_01033 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BARD7_01034 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BARD7_01036 ENOG4105EYH Exonuclease BARD7_01045 ENOG4105ERH Fumarylacetoacetate hydrolase BARD7_01047 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BARD7_01049 ENOG4105CAQ asparagine synthetase BARD7_01051 ENOG4105UQX Mate efflux family protein BARD7_01052 ENOG4106HBX Transcriptional Regulator AraC Family BARD7_01053 ENOG4105ETE Transcriptional regulator (LacI family BARD7_01054 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BARD7_01055 ENOG4105SF0 DinB family BARD7_01056 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BARD7_01057 ENOG4105MYW Pentapeptide repeat protein BARD7_01058 ENOG4105MA6 gCN5-related N-acetyltransferase BARD7_01060 ENOG4108VPT UPF0234 protein BARD7_01061 ENOG4105QNR S1 RNA binding domain protein BARD7_01062 ENOG4105DIH basic membrane BARD7_01063 ENOG4105C8Q Methyl-accepting chemotaxis BARD7_01064 ENOG4107E6A Cytochrome p-450 BARD7_01066 ENOG4105EPR degv family BARD7_01067 ENOG4107AYK membrAne BARD7_01069 ENOG41073B9 BARD7_01071 ENOG4108KP7 hydrolase BARD7_01072 ENOG4108MXZ Esterase BARD7_01073 ENOG4105VG1 fes assembly suf system protein BARD7_01074 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BARD7_01075 ENOG4105IQ5 FAD linked oxidase domain protein BARD7_01077 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BARD7_01079 ENOG4105CAS nag kinase BARD7_01080 ENOG4105C8Y Acetylornithine aminotransferase BARD7_01081 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BARD7_01083 ENOG4105DBV ornithine carbamoyltransferase BARD7_01088 ENOG4107RMD Basic membrane lipoprotein BARD7_01091 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BARD7_01092 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BARD7_01094 ENOG4105C3U ABC transporter BARD7_01095 ENOG4108JQ7 (ABC) transporter BARD7_01098 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BARD7_01100 ENOG4105C31 Tryptophanyl-tRNA synthetase BARD7_01101 ENOG4108J59 Extracellular solute-binding protein, family 5 BARD7_01102 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BARD7_01103 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BARD7_01105 ENOG4108JQ7 (ABC) transporter BARD7_01108 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BARD7_01109 ENOG4108ZCF integral membrane protein BARD7_01110 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BARD7_01112 ENOG4105DPN Oligoendopeptidase f BARD7_01114 ENOG4105T58 Dithiol-disulfide isomerase BARD7_01115 ENOG4108Z18 K06886 hemoglobin BARD7_01116 ENOG4105E4C Lytic transglycosylase catalytic BARD7_01117 ENOG4105MIX Adenylate cyclase BARD7_01120 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BARD7_01121 ENOG4105EMS pseudouridine synthase BARD7_01122 ENOG4107S1Q Phosphatase BARD7_01124 ENOG4105ETU transcriptional activator (TenA BARD7_01125 ENOG4108VEU Thiamine monophosphate synthase BARD7_01129 ENOG4105D06 uba thif-type nad fad binding protein BARD7_01130 ENOG4105DWF phosphomethylpyrimidine kinase BARD7_01131 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BARD7_01132 ENOG4107A88 BARD7_01142 ENOG4105ENA helicase BARD7_01146 ENOG4105CJ1 ABC, transporter BARD7_01149 ENOG4108ZMI UPF0477 protein BARD7_01151 ENOG4105C28 cystathionine BARD7_01152 ENOG4105C28 cystathionine BARD7_01155 ENOG4105X3H Excalibur domain protein BARD7_01174 ENOG4105KT7 mgtC SapB transporter BARD7_01179 ENOG4108IEG Formate dehydrogenase Alpha subunit BARD7_01181 ENOG4106A3M Cytochrome p-450 BARD7_01182 ENOG41087PP glycosyltransferase MGT family BARD7_01184 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BARD7_01185 ENOG4105C4B ABC transporter, permease BARD7_01186 ENOG4108IXI (ABC) transporter BARD7_01188 ENOG4105Q95 Cupin 2, conserved barrel domain protein BARD7_01191 ENOG4105CT4 transporter BARD7_01192 ENOG4107KJX Transcriptional regulator BARD7_01193 ENOG4107QZW Altronate oxidoreductase BARD7_01194 ENOG4105CTX dehydratase BARD7_01195 ENOG4107TSN permease BARD7_01199 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BARD7_01200 ENOG4105KWG Pfam:DUF1696 BARD7_01201 ENOG4105K7W phage-related replication protein BARD7_01202 ENOG410635T phage-like element pbsx protein BARD7_01211 ENOG4108TFU terminase (Small subunit) BARD7_01212 ENOG4105IG6 Phage terminase, large subunit BARD7_01213 ENOG4108MDF Phage Portal Protein BARD7_01218 ENOG41060SN BARD7_01221 ENOG4105PQS phage protein BARD7_01222 ENOG4105FR7 XkdM protein, phage-like element PBSX BARD7_01223 ENOG4105MTC XkdN-like protein BARD7_01225 ENOG4108FKH Transglycosylase SLT domain BARD7_01225 ENOG4108FKH Transglycosylase SLT domain BARD7_01226 ENOG4108WZM domain protein BARD7_01227 ENOG4105X7F BARD7_01229 ENOG4105MFU Protein of unknown function (DUF2634) BARD7_01230 ENOG41066EA baseplate J family protein BARD7_01231 ENOG410906S phage-like element pbsx protein xkdt BARD7_01233 ENOG41068G1 BARD7_01239 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BARD7_01242 ENOG4105CJ3 phosphate transporter BARD7_01243 ENOG4107GRR phosphate transport regulator BARD7_01244 ENOG4107R7I amino acid BARD7_01246 ENOG4105EDW glycosyl transferase, family 39 BARD7_01247 ENOG4105CKK Glycosyl transferase, family 2 BARD7_01249 ENOG4105C0H protease BARD7_01251 ENOG4108ME1 Peptidase M55 D-aminopeptidase BARD7_01252 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BARD7_01253 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BARD7_01254 ENOG4105C3U ABC transporter BARD7_01256 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BARD7_01257 ENOG4105DTQ mandelate racemase muconate lactonizing BARD7_01258 ENOG4107SN7 NLP P60 protein BARD7_01259 ENOG4108JQ7 (ABC) transporter BARD7_01260 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BARD7_01261 ENOG4107TUM Amidinotransferase BARD7_01262 ENOG4108S4H thioesterase Superfamily protein BARD7_01263 ENOG4108428 Inherit from COG: -acetyltransferase BARD7_01265 ENOG41080TC multidrug resistance protein BARD7_01266 ENOG4105CIY formyltetrahydrofolate deformylase BARD7_01267 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BARD7_01270 ENOG4105K56 Transcriptional regulator BARD7_01271 ENOG4108ZHJ Organic hydroperoxide resistance protein BARD7_01274 ENOG4107TVC Glycosyl transferase, family 2 BARD7_01276 ENOG4105D8G Major Facilitator superfamily BARD7_01277 ENOG4108Y4K DNA-binding transcriptional activator BARD7_01278 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BARD7_01279 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BARD7_01281 ENOG4108W7F transporter, permease BARD7_01282 ENOG4108JJB ABC transporter BARD7_01283 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BARD7_01284 ENOG4105VRS hydrolase family 18 BARD7_01286 ENOG4105CJW magnesium transporter BARD7_01287 ENOG4105V75 Transcriptional regulator BARD7_01292 ENOG4105DQE DNA ligase BARD7_01293 ENOG4105FDF Could be involved in DNA repair (By similarity) BARD7_01294 ENOG4105BZU Histidine kinase BARD7_01295 ENOG4107T5V SNARE associated Golgi BARD7_01296 ENOG4107TS3 membrane protein, TerC BARD7_01297 ENOG4108WZW RNA polymerase sigma BARD7_01299 ENOG410681C small acid-soluble spore protein BARD7_01301 ENOG4105D0M Protease HtpX homolog BARD7_01303 ENOG410900G Protein of unknown function (DUF421) BARD7_01305 ENOG4108TGC Acyltransferase BARD7_01306 ENOG4105BZU Histidine kinase BARD7_01307 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BARD7_01309 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BARD7_01311 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BARD7_01313 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BARD7_01314 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BARD7_01315 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BARD7_01316 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BARD7_01318 ENOG4105BZU Histidine kinase BARD7_01319 ENOG41090MY MarR family Transcriptional regulator BARD7_01320 ENOG4105ER2 Ompa motb domain protein BARD7_01321 ENOG4105E14 MotA TolQ exbB proton channel BARD7_01323 ENOG4108K88 Membrane BARD7_01325 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BARD7_01326 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BARD7_01327 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BARD7_01328 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BARD7_01332 ENOG4105F0V Cell wall hydrolase BARD7_01335 ENOG4105C59 p-type ATPase BARD7_01336 ENOG4105DC7 peptidase M24 BARD7_01339 ENOG4105CID antiterminator BARD7_01341 ENOG4105KRI phosphocarrier protein (HPr BARD7_01342 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BARD7_01344 ENOG4105F6S Spore photoproduct lyase BARD7_01345 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BARD7_01346 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BARD7_01347 ENOG4105K4I Scp-like extracellular BARD7_01349 ENOG4105BZU Histidine kinase BARD7_01350 ENOG4105CHM Aminotransferase BARD7_01352 ENOG4107R88 Chemotaxis protein (CheV) BARD7_01353 ENOG4105UIN BARD7_01355 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BARD7_01357 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BARD7_01359 ENOG4105EPM Diguanylate phosphodiesterase BARD7_01360 ENOG4107IN1 Protein of unknown function (DUF1797) BARD7_01361 ENOG4108XRC Protein of unknown function (DUF458) BARD7_01367 ENOG4105NQC Flavodoxin BARD7_01371 ENOG4105D8X mechanosensitive ion channel BARD7_01372 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BARD7_01376 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BARD7_01377 ENOG4105D06 uba thif-type nad fad binding protein BARD7_01378 ENOG4105CVM Molybdenum cofactor synthesis domain protein BARD7_01379 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BARD7_01380 ENOG4108ZAF Molybdopterin BARD7_01381 ENOG41067WU Molybdopterin converting factor (Subunit 1) BARD7_01383 ENOG4107X8C Efflux transporter RND family MFP subunit BARD7_01384 ENOG4105C19 ABC transporter BARD7_01385 ENOG4107RBB ABC transporter, permease BARD7_01386 ENOG4105E98 transcriptional regulator DeoR family BARD7_01387 ENOG4105DE4 1-phosphofructokinase BARD7_01388 ENOG4105DM4 PTS System BARD7_01391 ENOG4105C5H ABC transporter BARD7_01392 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BARD7_01397 ENOG4105BZU Histidine kinase BARD7_01399 ENOG4107ZYR domain protein BARD7_01400 ENOG4105CPN adenine deaminase BARD7_01401 ENOG4105CN5 Metallo-Beta-Lactamase BARD7_01402 ENOG4106148 UPF0356 protein BARD7_01403 ENOG4108X4Q Hydrolase BARD7_01404 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BARD7_01408 ENOG4105CPP Dehydrogenase, E1 component BARD7_01409 ENOG4105C7S Dehydrogenase BARD7_01410 ENOG4107QN2 dihydrolipoyl dehydrogenase BARD7_01413 ENOG4105CXN decarboxylase BARD7_01414 ENOG4105WBI UPF0223 protein BARD7_01417 ENOG4105ECY inositol monophosphatase BARD7_01419 ENOG4105D4Y metalloprotease BARD7_01423 ENOG4105CI3 gtp-binding protein typa BARD7_01424 ENOG4105QA2 BARD7_01427 ENOG4108IAB Phoh family BARD7_01429 ENOG4105CSV Glutaminase BARD7_01431 ENOG4105CNI cell division protein FtsW BARD7_01432 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BARD7_01434 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BARD7_01436 ENOG4105BZ9 Cytochrome C oxidase, subunit I BARD7_01437 ENOG4105CCU oxidase (Subunit III) BARD7_01438 ENOG41064X9 cytochrome C oxidase subunit IV BARD7_01441 ENOG41080XQ Signal transduction protein with cbs domains BARD7_01442 ENOG4106UY4 Inherit from COG: Scp-like extracellular BARD7_01447 ENOG4106H78 methyltransferase BARD7_01448 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BARD7_01449 ENOG4105H20 Sporulation integral membrane protein YlbJ BARD7_01450 ENOG4105D78 K07001 NTE family protein BARD7_01451 ENOG41063PX domain protein BARD7_01452 ENOG4105CDE UPF0348 protein BARD7_01453 ENOG4105KNH Nucleic acid-binding protein BARD7_01454 ENOG41067VY 50S ribosomal protein L32 BARD7_01459 ENOG4108V6E Cell division protein mraZ BARD7_01460 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BARD7_01462 ENOG4105CJN penicillin-binding protein BARD7_01463 ENOG4105CJN penicillin-binding protein BARD7_01464 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BARD7_01465 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BARD7_01466 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BARD7_01467 ENOG4105CNI cell division protein FtsW BARD7_01468 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BARD7_01469 ENOG4105D4A Cell wall formation (By similarity) BARD7_01470 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BARD7_01471 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BARD7_01472 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BARD7_01474 ENOG4105FFI sigma-e processing peptidase spoiiga BARD7_01475 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_01477 ENOG4105DKW ABC transporter BARD7_01479 ENOG4105WR5 sporulation protein, YlmC YmxH family BARD7_01480 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BARD7_01481 ENOG4105DFA alanine racemase domain protein BARD7_01482 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BARD7_01483 ENOG41067XK integral membrane protein BARD7_01484 ENOG4105DBK s4 domain protein BARD7_01486 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BARD7_01488 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BARD7_01489 ENOG4105C34 Pseudouridine synthase BARD7_01490 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BARD7_01492 ENOG4105CXT aspartate transcarbamylase BARD7_01494 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BARD7_01495 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BARD7_01496 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BARD7_01497 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BARD7_01498 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BARD7_01499 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BARD7_01503 ENOG4107RIQ Sulfate adenylate transferase BARD7_01505 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BARD7_01506 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BARD7_01507 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BARD7_01509 ENOG4105F23 Fibronectin-binding protein BARD7_01511 ENOG4105DSJ YicC domain protein BARD7_01512 ENOG4105KC4 UPF0296 protein BARD7_01513 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BARD7_01515 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BARD7_01516 ENOG4105C25 Primosomal protein n' BARD7_01517 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BARD7_01518 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BARD7_01519 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BARD7_01520 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BARD7_01521 ENOG4108ZF3 Phosphatase BARD7_01522 ENOG4105D9P serine threonine protein kinase BARD7_01523 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BARD7_01524 ENOG4105DJV ribulose-phosphate 3-epimerase BARD7_01525 ENOG4105FJ0 thiamine BARD7_01526 ENOG4105VB9 50S ribosomal protein l28 BARD7_01527 ENOG4108ZAA Alkaline-shock protein BARD7_01528 ENOG4105DP4 dak2 domain fusion protein ylov BARD7_01530 ENOG4105EJQ L-serine dehydratase BARD7_01531 ENOG4105CB5 ATP-dependent DNA helicase recG BARD7_01532 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BARD7_01533 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BARD7_01534 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BARD7_01535 ENOG4105CHR reductase BARD7_01536 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BARD7_01537 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BARD7_01538 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BARD7_01539 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BARD7_01540 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BARD7_01542 ENOG4105K5M 30s ribosomal protein S16 BARD7_01543 ENOG4108BW8 UPF0109 protein BARD7_01546 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BARD7_01547 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BARD7_01548 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BARD7_01549 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BARD7_01551 ENOG4105VM1 flagellar BARD7_01552 ENOG4105CMV Succinyl-CoA synthetase subunit beta BARD7_01553 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BARD7_01554 ENOG4105C79 DNA protecting protein DprA BARD7_01555 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BARD7_01556 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BARD7_01557 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BARD7_01558 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BARD7_01559 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BARD7_01561 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BARD7_01562 ENOG4108ZC9 flagellar basal-body rod protein flgc BARD7_01563 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BARD7_01564 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BARD7_01565 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BARD7_01568 ENOG4106YF4 Flagellar biosynthesis chaperone BARD7_01570 ENOG410696Y Flagellar hook-length control protein BARD7_01571 ENOG410822I Flagellar hook capping protein BARD7_01572 ENOG4108JQA flagellar BARD7_01574 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BARD7_01575 ENOG4105DD5 Flagellar motor switch protein BARD7_01576 ENOG4107YTP response regulator receiver protein BARD7_01578 ENOG4105CN7 Flagellar biosynthetic protein FliP BARD7_01579 ENOG4105VS8 Flagellar biosynthetic protein fliq BARD7_01580 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BARD7_01581 ENOG4105D00 flagellar biosynthetic protein flhB BARD7_01582 ENOG4105D7B Flagellar biosynthesis protein flha BARD7_01583 ENOG4105FZW flagellar biosynthesis regulator FlhF BARD7_01585 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BARD7_01586 ENOG4105CBS Chea signal transduction histidine kinase BARD7_01587 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BARD7_01589 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BARD7_01590 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_01592 ENOG4105CE9 30S ribosomal protein S2 BARD7_01593 ENOG4105CE9 30S ribosomal protein S2 BARD7_01595 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BARD7_01596 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BARD7_01597 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BARD7_01598 ENOG4105KNE Phosphatidate cytidylyltransferase BARD7_01600 ENOG4105DZP Membrane-associated zinc metalloprotease BARD7_01601 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BARD7_01602 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BARD7_01603 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BARD7_01604 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BARD7_01605 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BARD7_01606 ENOG4105CHV Transcription elongation factor NusA BARD7_01607 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BARD7_01608 ENOG4105VHM ribosomal protein BARD7_01609 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BARD7_01610 ENOG4105W7A Protein of unknown function (DUF503) BARD7_01611 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BARD7_01612 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BARD7_01613 ENOG4105DTN riboflavin biosynthesis protein ribF BARD7_01614 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BARD7_01615 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BARD7_01617 ENOG4105C1V Peptidase, M16 BARD7_01619 ENOG4105E35 Dipicolinate synthase subunit A BARD7_01620 ENOG4108S0H Dipicolinic acid synthetase, b subunit BARD7_01621 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BARD7_01623 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BARD7_01625 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BARD7_01627 ENOG4105CNU cell division protein FtsK BARD7_01628 ENOG4105FDP GntR family transcriptional regulator BARD7_01631 ENOG4105EYF MMPL domain protein BARD7_01634 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BARD7_01635 ENOG4105XZV Protein of unknown function (DUF3243) BARD7_01638 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BARD7_01639 ENOG4105CEV competence damage-inducible protein BARD7_01640 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BARD7_01641 ENOG4108A04 Beta-lactamase BARD7_01643 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BARD7_01644 ENOG4105D48 metallophosphoesterase BARD7_01645 ENOG4105MCT stage V sporulation protein S BARD7_01646 ENOG4105CPQ Dehydrogenase BARD7_01647 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BARD7_01648 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BARD7_01652 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BARD7_01653 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BARD7_01659 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BARD7_01660 ENOG410682Q Phage transcriptional regulator, ArpU BARD7_01666 ENOG4108151 Beta-lactamase domain protein BARD7_01667 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BARD7_01668 ENOG4108JA1 polyketide synthase BARD7_01669 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BARD7_01670 ENOG41062T2 Acyl carrier protein BARD7_01671 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BARD7_01672 ENOG4108MGH Enoyl-CoA hydratase BARD7_01673 ENOG4108KQ6 Enoyl-CoA hydratase BARD7_01674 ENOG4105C0W non-ribosomal peptide synthetase BARD7_01675 ENOG4107SQU synthase BARD7_01677 ENOG4105C0W non-ribosomal peptide synthetase BARD7_01679 ENOG4106A3M Cytochrome p-450 BARD7_01680 ENOG4105WFK nuclease BARD7_01681 ENOG4105XPP Protein of unknown function (DUF1275) BARD7_01683 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BARD7_01685 ENOG4105K7W phage-related replication protein BARD7_01686 ENOG4108X3M OsmC Ohr family protein BARD7_01691 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BARD7_01696 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BARD7_01697 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BARD7_01698 ENOG4105U6W MutT NUDIX family protein BARD7_01699 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BARD7_01700 ENOG4106F1P AAA ATPase, central domain protein BARD7_01701 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BARD7_01702 ENOG4105CXI aluminum resistance protein BARD7_01703 ENOG4105KV4 Transcriptional regulator BARD7_01704 ENOG4105C5F glutamine synthetase BARD7_01705 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BARD7_01709 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BARD7_01716 ENOG4107T94 Endo-14-beta-xylanase BARD7_01718 ENOG4105CT4 transporter BARD7_01719 ENOG4105DSG hydrolase family 43 BARD7_01721 ENOG4105C93 Xylose Isomerase BARD7_01722 ENOG4105CMG Carbohydrate kinase BARD7_01724 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BARD7_01728 ENOG410780I phosphoprotein phosphatase activity BARD7_01732 ENOG4105DQ4 alcohol dehydrogenase BARD7_01736 ENOG4105EPI acetyltransferase, (GNAT) family BARD7_01743 ENOG4108M1A Chitin-binding protein BARD7_01748 ENOG4105YB8 TM2 domain containing protein BARD7_01749 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BARD7_01751 ENOG4105K7W phage-related replication protein BARD7_01756 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BARD7_01758 ENOG4108SVB resolvase BARD7_01759 ENOG4105VPS UPF0291 protein BARD7_01760 ENOG4105CV1 Transketolase (EC 2.2.1.1) BARD7_01762 ENOG4105VXM UPF0154 protein BARD7_01764 ENOG4107QIV Cytochrome c biogenesis protein BARD7_01771 ENOG4108I0Z Aconitate hydratase BARD7_01772 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BARD7_01775 ENOG41067CD Small, acid-soluble spore protein Tlp BARD7_01777 ENOG4105MI2 BARD7_01778 ENOG4105W8X HesB YadR YfhF-family protein BARD7_01779 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BARD7_01780 ENOG4105K4P CoA-binding domain protein BARD7_01781 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BARD7_01789 ENOG4105FVX BARD7_01792 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BARD7_01794 ENOG4107SYN Glycosyl hydrolases family 43 BARD7_01799 ENOG4105DTD Dehydrogenase BARD7_01800 ENOG4108IIH CoA-transferase subunit B BARD7_01801 ENOG4105D6N CoA-transferase, subunit a BARD7_01802 ENOG4106A3M Cytochrome p-450 BARD7_01803 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BARD7_01804 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BARD7_01805 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BARD7_01806 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BARD7_01809 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BARD7_01810 ENOG4107T5V SNARE associated Golgi BARD7_01811 ENOG4107QX3 carboxylase BARD7_01812 ENOG4105E39 Enoyl-CoA hydratase BARD7_01813 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BARD7_01814 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BARD7_01815 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BARD7_01816 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_01817 ENOG4105C1G acyl-Coa dehydrogenase BARD7_01818 ENOG4105F32 YngK protein BARD7_01819 ENOG4106U2H Protein of unknown function (DUF1360) BARD7_01822 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BARD7_01823 ENOG4108N2V aldose 1-epimerase BARD7_01824 ENOG4107QJQ Mate efflux family protein BARD7_01829 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BARD7_01830 ENOG4108RWP Major Facilitator Superfamily protein BARD7_01831 ENOG4105WAB arsR family transcriptional regulator BARD7_01832 ENOG4105C22 threonyL-tRNA synthetase BARD7_01833 ENOG4108KSA LysR family transcriptional regulator BARD7_01834 ENOG4105CB2 alcohol dehydrogenase BARD7_01836 ENOG4105BZ8 glutamate synthase BARD7_01837 ENOG4105CBC glutamate synthase BARD7_01838 ENOG4105C5Q Transcriptional regulator BARD7_01839 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BARD7_01844 ENOG4108UB7 BARD7_01846 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BARD7_01847 ENOG4105BZU Histidine kinase BARD7_01848 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_01849 ENOG4105IE8 Alpha-ketoglutarate permease BARD7_01850 ENOG4107U6E carbohydrate kinase FGGY BARD7_01851 ENOG4108M3J Dehydrogenase BARD7_01852 ENOG4108J2R molybdopterin oxidoreductase BARD7_01857 ENOG4108Z7R Chaperone CsaA BARD7_01858 ENOG4105FTV AraC Family Transcriptional Regulator BARD7_01860 ENOG4108W8B Beta-lactamase domain protein BARD7_01862 ENOG4105KTU Transcriptional regulator, arsr family BARD7_01864 ENOG4108SJC Membrane BARD7_01869 ENOG41069ER domain protein BARD7_01870 ENOG4105C9U ATP-dependent DNA helicase RecQ BARD7_01871 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BARD7_01872 ENOG4105SCY DNAK suppressor BARD7_01881 ENOG4105C26 Dehydrogenase BARD7_01882 ENOG4105EWU Squalene--hopene cyclase BARD7_01883 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BARD7_01884 ENOG4105C8J )-transporter BARD7_01885 ENOG4105C09 Bile acid BARD7_01887 ENOG4105C7S Dehydrogenase BARD7_01888 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BARD7_01889 ENOG4107T89 von Willebrand factor, type A BARD7_01890 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BARD7_01892 ENOG4105K4H Nlp p60 protein BARD7_01893 ENOG41087PP glycosyltransferase MGT family BARD7_01896 ENOG4107QMU Mate efflux family protein BARD7_01897 ENOG4106SCS STAS domain BARD7_01901 ENOG4105FR1 rard protein BARD7_01904 ENOG41090U3 tautomerase BARD7_01907 ENOG4105FBA Phospholipase Carboxylesterase BARD7_01910 ENOG4105E1V na solute symporter BARD7_01912 ENOG4105CS2 ec 3.2.1.21 BARD7_01913 ENOG4108S3Y transcriptional regulator BARD7_01917 ENOG4108VXD carboxy-peptidase BARD7_01918 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BARD7_01920 ENOG4106Z5R BARD7_01921 ENOG410841Q phosphoesterase PA-phosphatase related protein BARD7_01925 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BARD7_01928 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BARD7_01929 ENOG4108TSC N-acetyltransferase BARD7_01930 ENOG4107S4Y M20 DapE family protein YgeY BARD7_01933 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BARD7_01941 ENOG4105C5E polysaccharide biosynthesis protein BARD7_01944 ENOG4105DMF Dehydrogenase BARD7_01949 ENOG4105E0X reductase BARD7_01950 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BARD7_01952 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BARD7_01953 ENOG41090WU lipolytic protein G-D-S-L family BARD7_01954 ENOG4108KF3 Electron transport protein SCO1 SenC BARD7_01956 ENOG4105C7B Threonine dehydratase BARD7_01958 ENOG4108UT2 hemolysin iii BARD7_01960 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BARD7_01961 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BARD7_01963 ENOG4107YX5 Pfam:DUF548 BARD7_01964 ENOG4108Y6J UPF0403 protein BARD7_01965 ENOG4105C01 Dihydroxy-acid dehydratase BARD7_01968 ENOG4108V06 Glutathione peroxidase BARD7_01970 ENOG4105CVG Homoserine O-transsuccinylase BARD7_01978 ENOG41081VK Ribonuclease BARD7_01983 ENOG410890F Dynamin family BARD7_01985 ENOG41065KQ synthase BARD7_01989 ENOG4105C2W permease BARD7_01990 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BARD7_01991 ENOG4105CTD carboxy-peptidase BARD7_01992 ENOG4105DVT helicase BARD7_01995 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BARD7_01996 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BARD7_01997 ENOG4108UKS UPF0398 protein BARD7_02000 ENOG4107X2U Inherit from COG: Exonuclease-like protein BARD7_02001 ENOG4108I5C dEAD DEAH box helicase BARD7_02010 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BARD7_02011 ENOG4105BZ4 penicillin-binding protein BARD7_02013 ENOG4105CSM endonuclease III BARD7_02015 ENOG4105C5S asparaginyl-tRNA synthetase BARD7_02016 ENOG4105CHM Aminotransferase BARD7_02018 ENOG4105YAC BARD7_02019 ENOG4105DVT helicase BARD7_02020 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BARD7_02022 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BARD7_02024 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BARD7_02025 ENOG4105CPK Glycosyl transferase (Group 1 BARD7_02026 ENOG4105FJR Lmbe family BARD7_02027 ENOG4108Z5K methylglyoxal synthase BARD7_02028 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BARD7_02029 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BARD7_02030 ENOG4108JYZ YitT family BARD7_02031 ENOG4105F0F Oxalate decarboxylase BARD7_02035 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BARD7_02039 ENOG41068YB TPR repeat-containing protein BARD7_02040 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BARD7_02042 ENOG4105CIH Imidazole acetol-phosphate transaminase BARD7_02044 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BARD7_02045 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BARD7_02046 ENOG4105DK0 Indole-3-glycerol phosphate synthase BARD7_02048 ENOG4105CRQ synthase (Component I) BARD7_02049 ENOG4105KHN chorismate mutase BARD7_02051 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BARD7_02052 ENOG4105BZU Histidine kinase BARD7_02053 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BARD7_02054 ENOG4105EAH synthase BARD7_02055 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BARD7_02056 ENOG4105XXQ heptaprenyl diphosphate synthase component I BARD7_02057 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BARD7_02058 ENOG4105EUJ GTP cyclohydrolase i BARD7_02059 ENOG4105K70 DNA-binding protein BARD7_02060 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BARD7_02064 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BARD7_02065 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BARD7_02069 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BARD7_02070 ENOG4105CAT Cytidine monophosphate kinase BARD7_02073 ENOG4105MSI germination protein ypeb BARD7_02075 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BARD7_02076 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BARD7_02079 ENOG4107RGJ metallophosphoesterase BARD7_02082 ENOG4105I7S Abortive infection protein BARD7_02083 ENOG4105C9U ATP-dependent DNA helicase RecQ BARD7_02084 ENOG4105T7X BARD7_02086 ENOG4108SAX Membrane BARD7_02087 ENOG4108JQ1 Dehydrogenase BARD7_02090 ENOG4105BZU Histidine kinase BARD7_02091 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_02092 ENOG4105CRE cytochrome C BARD7_02093 ENOG4107TWT Cytochrome c biogenesis protein BARD7_02095 ENOG4105FE9 pseudouridine synthase BARD7_02097 ENOG4108JIC nucleoside recognition domain protein BARD7_02098 ENOG4105DZ1 carboxypeptidase BARD7_02100 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BARD7_02101 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BARD7_02105 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BARD7_02106 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BARD7_02107 ENOG4108R6K riboflavin synthase, subunit alpha BARD7_02112 ENOG4107ZE5 PPIases accelerate the folding of proteins BARD7_02113 ENOG4105PTM secreted protein BARD7_02114 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BARD7_02116 ENOG4105G6R Stage v sporulation protein ae BARD7_02118 ENOG4105CZ3 stage V sporulation protein ad BARD7_02119 ENOG41090VF Stage v sporulation protein ac BARD7_02122 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_02123 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BARD7_02124 ENOG41082AN stage II sporulation protein BARD7_02125 ENOG4105DZ1 carboxypeptidase BARD7_02126 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BARD7_02127 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BARD7_02128 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BARD7_02130 ENOG4105I3K Ferric uptake regulator, Fur family BARD7_02131 ENOG4105MZ9 stage II sporulation protein m BARD7_02135 ENOG4105DFD Na H antiporter BARD7_02136 ENOG4108IJ0 Aspartate ammonia-lyase BARD7_02137 ENOG4105HDK L-asparaginase BARD7_02138 ENOG4108IMY Transcriptional regulator BARD7_02140 ENOG4108YZ4 nudix hydrolase BARD7_02142 ENOG4105CPC Aldo Keto reductase BARD7_02146 ENOG4106HZJ BARD7_02147 ENOG4105RHY Pfam:UPF0157 BARD7_02148 ENOG4105KAC Antibiotic biosynthesis monooxygenase BARD7_02149 ENOG4108XET gCN5-related N-acetyltransferase BARD7_02150 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BARD7_02153 ENOG4105C02 permease BARD7_02155 ENOG4105CS9 pantothenic acid kinase BARD7_02157 ENOG4108IXY short-chain dehydrogenase reductase BARD7_02158 ENOG41069FQ Metallo-beta-lactamase superfamily BARD7_02159 ENOG4105II7 pyrroline-5-carboxylate reductase BARD7_02160 ENOG4108K70 Transcriptional regulator BARD7_02162 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BARD7_02164 ENOG410861F 50S ribosomal protein L33 BARD7_02165 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BARD7_02166 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BARD7_02167 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BARD7_02168 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BARD7_02170 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BARD7_02171 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BARD7_02172 ENOG4108HNZ carboxyl transferase BARD7_02173 ENOG4108ZVT methylmalonyl-coA epimerase BARD7_02175 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BARD7_02176 ENOG4108QEG Membrane BARD7_02177 ENOG4105CDA abc transporter atp-binding protein BARD7_02178 ENOG4105E5Q amino acid AbC transporter BARD7_02179 ENOG4108HW3 (ABC) transporter BARD7_02180 ENOG4108Y6J UPF0403 protein BARD7_02181 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BARD7_02182 ENOG4105C7S Dehydrogenase BARD7_02183 ENOG4105CPP Dehydrogenase, E1 component BARD7_02186 ENOG4105CKM Branched-chain carboxylic acid kinase BARD7_02187 ENOG4107RDP Dehydrogenase BARD7_02189 ENOG4108JUB Transcriptional regulator BARD7_02190 ENOG4106CCJ Protein of unknown function (DUF2627) BARD7_02191 ENOG4105CR4 methylisocitrate lyase BARD7_02192 ENOG4105DXD 2-methylcitrate dehydratase BARD7_02194 ENOG4105C1G acyl-Coa dehydrogenase BARD7_02195 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BARD7_02197 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BARD7_02198 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BARD7_02203 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BARD7_02206 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BARD7_02208 ENOG4107QQR Sporulation BARD7_02209 ENOG4105S1Z Stage IV sporulation protein B BARD7_02210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BARD7_02211 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BARD7_02212 ENOG4105DX0 Hemolysin A BARD7_02213 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BARD7_02214 ENOG4105CTB Polyprenyl synthetase BARD7_02215 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BARD7_02216 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BARD7_02217 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BARD7_02218 ENOG4105M7K Involved in the transcription termination process (By similarity) BARD7_02219 ENOG4108ZSR alkaline shock protein BARD7_02220 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BARD7_02224 ENOG410644B Stage III sporulation protein af BARD7_02226 ENOG4105KQ4 Stage iii sporulation protein ad BARD7_02227 ENOG4108CQH stage III sporulation protein AC BARD7_02228 ENOG4105KR5 Stage iii sporulation protein BARD7_02229 ENOG4105CD2 stage iii sporulation protein aa BARD7_02231 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BARD7_02232 ENOG4105DC7 peptidase M24 BARD7_02234 ENOG4105CBJ Metal-dependent enzyme BARD7_02238 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BARD7_02239 ENOG4105WZW rhodanese family BARD7_02240 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BARD7_02242 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BARD7_02243 ENOG4105C0D helicase BARD7_02246 ENOG4108IMY Transcriptional regulator BARD7_02248 ENOG4105VFR signal peptidase BARD7_02260 ENOG4105C37 (CBS) domain BARD7_02265 ENOG4105C5X domain protein BARD7_02274 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BARD7_02275 ENOG4105WDJ 50S ribosomal protein L33 BARD7_02277 ENOG41068DG YceG-like family BARD7_02278 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BARD7_02279 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BARD7_02280 ENOG4105E2Z phosphate ABC transporter (Permease BARD7_02281 ENOG4105C8U phosphate abc transporter BARD7_02282 ENOG4105CVA phosphate BARD7_02283 ENOG4107RF6 penicillin-binding protein BARD7_02285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BARD7_02286 ENOG4105SXS Protein of unknown function (DUF456) BARD7_02289 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BARD7_02290 ENOG41063Y9 BARD7_02291 ENOG4108U5J '-nucleotidase BARD7_02292 ENOG4105N80 Ferric uptake regulator, Fur family BARD7_02293 ENOG4108JYZ YitT family BARD7_02294 ENOG41069ZM Protein of unknown function (DUF2624) BARD7_02295 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BARD7_02298 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BARD7_02299 ENOG4105EGD dinuclear metal center protein, YbgI family BARD7_02302 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_02303 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BARD7_02304 ENOG4108UPT UPF0178 protein BARD7_02305 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BARD7_02307 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BARD7_02308 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BARD7_02309 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BARD7_02311 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BARD7_02312 ENOG4105KG3 cytidine deaminase BARD7_02313 ENOG4107YR5 Diacylglycerol kinase BARD7_02314 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BARD7_02315 ENOG4105CTJ Metal Dependent Phosphohydrolase BARD7_02316 ENOG4105C9A Phoh family BARD7_02317 ENOG4105EI1 sporulation protein yqfd BARD7_02318 ENOG41068P3 sporulation protein YqfC BARD7_02320 ENOG4105DI5 UPF0365 protein BARD7_02321 ENOG4105F7J membrane-bound serine protease BARD7_02322 ENOG4105KTH gatB Yqey BARD7_02325 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BARD7_02326 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BARD7_02327 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BARD7_02328 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BARD7_02329 ENOG4105CFG Acts as a chaperone (By similarity) BARD7_02330 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BARD7_02331 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BARD7_02332 ENOG4105CSA Coproporphyrinogen iii oxidase BARD7_02333 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BARD7_02335 ENOG4108ZRV stage ii sporulation protein p BARD7_02336 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BARD7_02337 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BARD7_02338 ENOG4105TQK DNA polymerase iii, delta' subunit BARD7_02340 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BARD7_02341 ENOG4108UK2 deaminase BARD7_02342 ENOG4105KQC Competence protein BARD7_02344 ENOG4108D32 Methyltransferase BARD7_02346 ENOG4108WF2 Metal Dependent Phosphohydrolase BARD7_02347 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BARD7_02348 ENOG410812S Rna-binding protein BARD7_02349 ENOG4105E2X shikimate dehydrogenase BARD7_02350 ENOG4105CQW ribosome biogenesis GTPase YqeH BARD7_02351 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BARD7_02355 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BARD7_02356 ENOG41080BT SNARE associated Golgi BARD7_02358 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_02361 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BARD7_02363 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_02364 ENOG4108J8C transporter major facilitator family protein BARD7_02366 ENOG4105DQF Hydrolase BARD7_02367 ENOG4108HCJ Hydrolase BARD7_02369 ENOG4105DG6 mannose-6-phosphate isomerase BARD7_02370 ENOG4105DM4 PTS System BARD7_02373 ENOG4108Z66 YbaK ebsC protein BARD7_02374 ENOG4107RSM transcriptional regulator BARD7_02375 ENOG4105D94 Major Facilitator Superfamily BARD7_02376 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BARD7_02377 ENOG41082JN Transcriptional regulator BARD7_02380 ENOG4105TMB Formate nitrite transporter BARD7_02381 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BARD7_02383 ENOG4108JB9 formate dehydrogenase BARD7_02386 ENOG4105C28 cystathionine BARD7_02392 ENOG4107XRG penicillin-binding protein BARD7_02393 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BARD7_02395 ENOG4105CFP Peptidase U32 BARD7_02396 ENOG4105XYU peptidase (U32 family) BARD7_02397 ENOG4108VQJ O-methyltransferase BARD7_02398 ENOG4105HHA aminodeoxychorismate lyase BARD7_02400 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BARD7_02401 ENOG4105VBH UPF0297 protein BARD7_02402 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BARD7_02403 ENOG4105C02 permease BARD7_02404 ENOG4105CDA abc transporter atp-binding protein BARD7_02405 ENOG4105CT1 (ABC) transporter BARD7_02406 ENOG4105EAD ABC transporter BARD7_02407 ENOG4105DRP amino acid AbC transporter BARD7_02409 ENOG41060CR BARD7_02411 ENOG4105C7H Helicase, RecD TraA family BARD7_02413 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BARD7_02414 ENOG4105C3J Cysteine desulfurase BARD7_02416 ENOG4105D1H recombination factor protein RarA BARD7_02417 ENOG4105CUZ uba thif-type nad fad binding protein BARD7_02418 ENOG4105C9M aspartyl-trna synthetase BARD7_02419 ENOG4105CUT histidyl-tRNA synthetase BARD7_02422 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BARD7_02423 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BARD7_02424 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BARD7_02426 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BARD7_02427 ENOG41067VP Protein of unknown function (DUF1049) BARD7_02428 ENOG4105NCW Trka-c domain protein BARD7_02429 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BARD7_02431 ENOG4105CKP Polysaccharide Biosynthesis Protein BARD7_02432 ENOG4108QG2 Membrane BARD7_02433 ENOG4105NAP BARD7_02434 ENOG4105VIE preprotein translocase, subunit YajC BARD7_02435 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BARD7_02436 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BARD7_02437 ENOG41061AI Protein of unknown function (DUF2905) BARD7_02438 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BARD7_02439 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BARD7_02443 ENOG4106678 morphogenetic protein associated with SpoVID BARD7_02444 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BARD7_02445 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BARD7_02446 ENOG4108IYU L-aspartate oxidase BARD7_02449 ENOG4105CQC Prephenate dehydratase BARD7_02451 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BARD7_02453 ENOG4105K46 50S ribosomal protein l27 BARD7_02454 ENOG4105X36 (ribosomal) protein BARD7_02455 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BARD7_02458 ENOG4107QMS site-determining protein BARD7_02459 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BARD7_02460 ENOG4105YHC Rod shape-determining protein MreD BARD7_02461 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BARD7_02462 ENOG4105DFF Rod shape-determining protein mreb BARD7_02463 ENOG4105W5Q DNA repair protein (RadC BARD7_02464 ENOG4108Z03 MAF-like protein BARD7_02466 ENOG4106A3R peptidase BARD7_02467 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BARD7_02468 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BARD7_02470 ENOG4106AR7 Spore coat protein BARD7_02471 ENOG41068KH stage VI sporulation protein D BARD7_02472 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BARD7_02473 ENOG4105D52 delta-aminolevulinic acid dehydratase BARD7_02475 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BARD7_02477 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BARD7_02479 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BARD7_02480 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BARD7_02481 ENOG4108IUQ atp-dependent protease BARD7_02482 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BARD7_02483 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BARD7_02485 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BARD7_02486 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BARD7_02487 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BARD7_02489 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BARD7_02490 ENOG4108ZP8 Acetolactate synthase small subunit BARD7_02491 ENOG4105C7K acetolactate synthase BARD7_02499 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BARD7_02505 ENOG4105M59 Phosphodiesterase, mj0936 family BARD7_02506 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BARD7_02507 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BARD7_02508 ENOG4108XJQ germination protein BARD7_02509 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BARD7_02510 ENOG41067TZ transcriptional regulator, MarR family BARD7_02511 ENOG4105PFC Transcriptional regulator BARD7_02513 ENOG4105E33 succinate dehydrogenase BARD7_02515 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BARD7_02517 ENOG4105CFH Aspartokinase BARD7_02518 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BARD7_02519 ENOG4105K63 Thioredoxin BARD7_02520 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BARD7_02521 ENOG4105C10 Electron transfer flavoprotein BARD7_02522 ENOG4105BZJ Electron transfer flavoprotein BARD7_02523 ENOG41060WC Enoyl-CoA hydratase BARD7_02524 ENOG4107Z3H Transcriptional regulator, TetR family BARD7_02525 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_02526 ENOG4108YV3 Protein of unknown function (DUF2711) BARD7_02528 ENOG4105C98 muts2 protein BARD7_02529 ENOG4105DCG PHP domain protein BARD7_02532 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BARD7_02533 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BARD7_02534 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BARD7_02535 ENOG4108RWN rrna methyltransferase BARD7_02536 ENOG41067MF small acid-soluble spore protein BARD7_02538 ENOG4105CQB FAD linked oxidase domain protein BARD7_02539 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BARD7_02541 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BARD7_02542 ENOG4105DRS transport system, permease BARD7_02545 ENOG4108MDK Dehydrogenase BARD7_02547 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BARD7_02548 ENOG4105EF1 ribulokinase BARD7_02550 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BARD7_02551 ENOG4105CN9 Peptidase m42 family protein BARD7_02553 ENOG410696E Membrane BARD7_02554 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BARD7_02555 ENOG4105VJV 50s ribosomal protein L35 BARD7_02556 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BARD7_02557 ENOG41067MG lrgb family BARD7_02559 ENOG4105DY9 regulatoR BARD7_02560 ENOG4108HRK Histidine kinase BARD7_02561 ENOG4105U0R haloacid dehalogenase-like hydrolase BARD7_02562 ENOG4105C22 threonyL-tRNA synthetase BARD7_02563 ENOG4108TDW sporulation protein YtxC BARD7_02568 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BARD7_02569 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BARD7_02570 ENOG4105KVH Transcriptional regulator BARD7_02571 ENOG4105F27 Major Facilitator BARD7_02572 ENOG4105CV8 reductase BARD7_02573 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BARD7_02575 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BARD7_02576 ENOG4105C2M dna polymerase I BARD7_02577 ENOG4105BZU Histidine kinase BARD7_02578 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BARD7_02580 ENOG4108HMX isocitrate dehydrogenase (NADP) BARD7_02581 ENOG4105BZN citrate synthase BARD7_02583 ENOG4108REF Sporulation integral membrane protein ytvi BARD7_02584 ENOG4105FS0 cytoplasmic membrane protein BARD7_02585 ENOG4105CA9 Pyruvate kinase BARD7_02586 ENOG4105CTQ phosphohexokinase BARD7_02587 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BARD7_02588 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BARD7_02589 ENOG4105C6K Malic enzyme BARD7_02590 ENOG4105C0B DNA polymerase III (alpha subunit) BARD7_02591 ENOG4105VV2 BARD7_02593 ENOG4106EVM BARD7_02594 ENOG4105SFS phosphoesterase RecJ domain protein BARD7_02597 ENOG4105E8R UPF0173 metal-dependent hydrolase BARD7_02600 ENOG4105CH7 arginosuccinase BARD7_02601 ENOG4105CDH Citrulline--aspartate ligase BARD7_02602 ENOG4105EPU Molybdenum cofactor synthesis domain protein BARD7_02603 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BARD7_02605 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BARD7_02606 ENOG4105KBJ sporulation protein ytfj BARD7_02608 ENOG4105VK3 rdd domain containing protein BARD7_02609 ENOG4105D07 Signal peptide peptidase, SppA BARD7_02610 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BARD7_02611 ENOG4105EFZ amidohydrolase BARD7_02612 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BARD7_02614 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BARD7_02619 ENOG4105U5Y Transcriptional regulator BARD7_02621 ENOG4105BZU Histidine kinase BARD7_02622 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BARD7_02623 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BARD7_02629 ENOG4108NGU Transcriptional regulator BARD7_02630 ENOG4108UMN azlc family BARD7_02632 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BARD7_02634 ENOG4105F1V Acetoin utilization protein BARD7_02635 ENOG4105W87 Cbs domain BARD7_02636 ENOG4105DGU Histone deacetylase BARD7_02637 ENOG4105ER2 Ompa motb domain protein BARD7_02638 ENOG4107R0U MotA TolQ exbB proton channel BARD7_02639 ENOG4105ETE Transcriptional regulator (LacI family BARD7_02640 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BARD7_02644 ENOG4105DFU Cell wall formation (By similarity) BARD7_02646 ENOG4108VDD TRNA binding domain protein BARD7_02649 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BARD7_02652 ENOG4105C6K Malic enzyme BARD7_02653 ENOG4105C8F Beta-lactamase domain protein BARD7_02654 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BARD7_02656 ENOG4108V15 phosphotransferase enzyme family BARD7_02659 ENOG4107F58 2'-5' rna ligase BARD7_02660 ENOG4105C6T cysteine synthase BARD7_02661 ENOG4107QSE Dipeptidase BARD7_02662 ENOG4105C7N Xanthine uracil vitamin C permease BARD7_02665 ENOG4105YW5 deoR family transcriptional regulator BARD7_02668 ENOG4105CBX hi0933 family BARD7_02669 ENOG4105C94 Transporter BARD7_02673 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BARD7_02674 ENOG4105I1K ABC transporter BARD7_02675 ENOG4105I1K ABC transporter BARD7_02679 ENOG41085GJ domain protein BARD7_02680 ENOG4105C8T Leucyl-tRNA synthetase BARD7_02682 ENOG4105BZU Histidine kinase BARD7_02683 ENOG410605W Major Facilitator BARD7_02686 ENOG4105C19 ABC transporter BARD7_02687 ENOG4105EWM Histidine kinase BARD7_02689 ENOG4107R34 abc transporter permease protein BARD7_02690 ENOG4105C19 ABC transporter BARD7_02694 ENOG4105DVE abc transporter atp-binding protein BARD7_02695 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BARD7_02698 ENOG4105N5T Radical SAM Protein BARD7_02701 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BARD7_02703 ENOG4105E8V Alpha Beta Hydrolase Fold protein BARD7_02704 ENOG4108Z0R Transferase BARD7_02705 ENOG4105C85 amino acid BARD7_02706 ENOG4105CAQ asparagine synthetase BARD7_02707 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BARD7_02708 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BARD7_02711 ENOG4105D2X ABC transporter substrate-binding protein BARD7_02713 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BARD7_02716 ENOG4108RMU ferritin dps family protein BARD7_02719 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BARD7_02720 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BARD7_02721 ENOG4108V2W Carbonate dehydratase BARD7_02722 ENOG4105NRA 50s ribosomal protein l31 type b BARD7_02726 ENOG4105DTQ mandelate racemase muconate lactonizing BARD7_02727 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_02728 ENOG4108IPT Naphthoate synthase BARD7_02729 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BARD7_02730 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BARD7_02731 ENOG4105E4F Isochorismate synthase BARD7_02758 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BARD7_02759 ENOG4105DZ6 Band 7 protein BARD7_02761 ENOG4106DF1 BARD7_02762 ENOG4108VNY MOSC domain protein BARD7_02763 ENOG4108JB8 alcohol dehydrogenase BARD7_02764 ENOG4105C26 Dehydrogenase BARD7_02765 ENOG4105TRT Transcriptional regulator BARD7_02768 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BARD7_02769 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BARD7_02773 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BARD7_02775 ENOG4105EE0 oxidoreductase BARD7_02776 ENOG4108Z0Z intracellular protease Pfpi family BARD7_02777 ENOG4105C8Q Methyl-accepting chemotaxis BARD7_02778 ENOG4105C8Q Methyl-accepting chemotaxis BARD7_02779 ENOG4105C8Q Methyl-accepting chemotaxis BARD7_02780 ENOG4105C8Q Methyl-accepting chemotaxis BARD7_02783 ENOG4105EA8 2-Nitropropane dioxygenase BARD7_02784 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BARD7_02786 ENOG4105C37 (CBS) domain BARD7_02789 ENOG4107PBV potassium channel BARD7_02790 ENOG4107PBV potassium channel BARD7_02793 ENOG4107QYV phosphohexose isomerase BARD7_02795 ENOG4105CHJ isochorismatase hydrolase BARD7_02797 ENOG4107QW4 alcohol dehydrogenase BARD7_02798 ENOG4105WG9 Conserved Protein BARD7_02800 ENOG4105CHM Aminotransferase BARD7_02801 ENOG4108ZB6 transcriptional regulator AsnC family BARD7_02802 ENOG4108MUZ hydrolase BARD7_02804 ENOG4105C87 Aminotransferase class I and II BARD7_02805 ENOG4108HGU Histidine kinase BARD7_02806 ENOG4105Y38 Kinase-associated protein B BARD7_02809 ENOG4105BZ4 penicillin-binding protein BARD7_02810 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BARD7_02813 ENOG4108MRH transcriptional regulatory protein BARD7_02814 ENOG4105DIH basic membrane BARD7_02815 ENOG4108JQ9 ABC transporter BARD7_02816 ENOG4105UIB (ABC) transporter BARD7_02819 ENOG4105D65 subunit l BARD7_02820 ENOG4105HC0 Na H antiporter BARD7_02821 ENOG4108ZE9 Monovalent cation H antiporter subunit C BARD7_02822 ENOG4108JPZ Monovalent cation H antiporter subunit D BARD7_02823 ENOG4105SC1 monovalent cation H antiporter subunit E BARD7_02825 ENOG4105KJM monovalent cation h antiporter subunit g BARD7_02826 ENOG4105KA0 thioesterase Superfamily protein BARD7_02828 ENOG4105BZU Histidine kinase BARD7_02833 ENOG4105D58 Diguanylate phosphodiesterase BARD7_02834 ENOG4105DAP Nicotinate phosphoribosyltransferase BARD7_02839 ENOG4105C02 permease BARD7_02842 ENOG410904N short-chain dehydrogenase reductase BARD7_02849 ENOG4108K8K Transcriptional regulator BARD7_02850 ENOG4105DCF alanine dehydrogenase BARD7_02852 ENOG4105WQT MbtH domain protein BARD7_02853 ENOG4105CEY Amp-dependent synthetase and ligase BARD7_02854 ENOG4105WQI isochorismatase BARD7_02855 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BARD7_02856 ENOG4105E4F Isochorismate synthase BARD7_02857 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BARD7_02858 ENOG4105NIV Esterase BARD7_02862 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BARD7_02864 ENOG41069ER domain protein BARD7_02866 ENOG4105CEP NADH dehydrogenase BARD7_02869 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BARD7_02870 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BARD7_02871 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BARD7_02872 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BARD7_02874 ENOG4105ZKE UPF0349 protein BARD7_02877 ENOG41083MR nifu domain-containing protein BARD7_02878 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BARD7_02879 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BARD7_02880 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BARD7_02881 ENOG4105D6E homoserine dehydrogenase BARD7_02883 ENOG4108W5N phosphatidylglycerophosphatase a BARD7_02884 ENOG4105D4U had-superfamily hydrolase, subfamily iia BARD7_02886 ENOG4105MMD transcriptional regulator BARD7_02887 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BARD7_02888 ENOG4105FAA peptidase M23 BARD7_02889 ENOG4108YTE sporulation protein YunB BARD7_02890 ENOG4107R8B 5'-nucleotidase BARD7_02892 ENOG4105I3N Conserved Protein BARD7_02894 ENOG4105CD3 dihydroorotase BARD7_02895 ENOG4105G9B Transcriptional regulator BARD7_02900 ENOG4105C5R Aminotransferase BARD7_02902 ENOG4108K8S endonuclease I BARD7_02903 ENOG4108IJ9 (ABC) transporter BARD7_02904 ENOG4105FDP GntR family transcriptional regulator BARD7_02905 ENOG4108KPW sugar kinase BARD7_02906 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BARD7_02907 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BARD7_02908 ENOG4105XN3 extracellular solute-binding protein family 1 BARD7_02909 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BARD7_02915 ENOG4105PKS Excinuclease abc c subunit domain protein BARD7_02916 ENOG4107VFR oxidoreductase BARD7_02919 ENOG41083Q9 chitosanase BARD7_02920 ENOG4105DIW FeS assembly protein SUFB BARD7_02921 ENOG4108UNV SUF system FeS assembly protein, NifU family BARD7_02922 ENOG4105C9B Cysteine desulfurase BARD7_02923 ENOG4105JRK feS assembly protein SufD BARD7_02924 ENOG4105C3K feS assembly ATPase SufC BARD7_02927 ENOG4105D01 (LipO)protein BARD7_02928 ENOG4108UMI ABC transporter, permease BARD7_02929 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BARD7_02934 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BARD7_02935 ENOG41080E8 Transcriptional regulator, Spx MgsR family BARD7_02936 ENOG4105C1G acyl-Coa dehydrogenase BARD7_02937 ENOG4105CHU acetyl-coa acetyltransferase BARD7_02941 ENOG4105C0R drug resistance transporter emrb qaca subfamily BARD7_02944 ENOG41067TZ transcriptional regulator, MarR family BARD7_02945 ENOG4105C0R drug resistance transporter emrb qaca subfamily BARD7_02947 ENOG4105E0A ABC, transporter BARD7_02950 ENOG4105E1F short-chain dehydrogenase reductase BARD7_02951 ENOG4105HUF DNA protection during starvation protein BARD7_02952 ENOG4105C0H protease BARD7_02954 ENOG4105F3H Histidine kinase BARD7_02956 ENOG41067SE Tetr family transcriptional regulator BARD7_02957 ENOG4105C9Q fumarate hydratase class II BARD7_02962 ENOG4105WH1 Two component transcriptional regulator luxr family BARD7_02963 ENOG4105ENE Histidine kinase BARD7_02966 ENOG41087YS Phage shock protein A BARD7_02969 ENOG4108WBT adenosyltransferase BARD7_02970 ENOG4105E0A ABC, transporter BARD7_02971 ENOG4105EHG Permease protein BARD7_02972 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BARD7_02973 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BARD7_02974 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BARD7_02976 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BARD7_02978 ENOG4106DF4 Sigma-70, region 4 BARD7_02980 ENOG4105F0F Oxalate decarboxylase BARD7_02982 ENOG4105E0A ABC, transporter BARD7_02983 ENOG4105EHG Permease protein BARD7_02984 ENOG4105DQ5 transport system permease protein BARD7_02986 ENOG4105JQZ Methyltransferase BARD7_02987 ENOG4105D5Q Arginine ornithine antiporter BARD7_02989 ENOG4107K5X Membrane-bound metal-dependent hydrolase BARD7_02990 ENOG4107QZ2 Sulfatase BARD7_02991 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BARD7_02992 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BARD7_02993 ENOG4105E0C molybdate abc transporter BARD7_02994 ENOG4105WH1 Two component transcriptional regulator luxr family BARD7_02996 ENOG4105CJ1 ABC, transporter BARD7_02998 ENOG4108KYE ABC-2 type transporter BARD7_03001 ENOG4105EEQ Na H antiporter BARD7_03002 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BARD7_03003 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BARD7_03004 ENOG4105EEM helicase BARD7_03005 ENOG4105EN6 Membrane BARD7_03008 ENOG4107ZQN disulfide bond BARD7_03009 ENOG4105C59 p-type ATPase BARD7_03010 ENOG4105C59 p-type ATPase BARD7_03011 ENOG410681U heavy metal transport detoxification protein BARD7_03012 ENOG4105VPX protein, conserved in bacteria BARD7_03013 ENOG4105D9R oxidoreductase BARD7_03014 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BARD7_03017 ENOG4105DEN Luciferase family BARD7_03018 ENOG4105CDA abc transporter atp-binding protein BARD7_03023 ENOG4108XSB acetyltransferase, (GNAT) family BARD7_03024 ENOG4108KSA LysR family transcriptional regulator BARD7_03025 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BARD7_03026 ENOG41067XF inhibitor BARD7_03027 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BARD7_03028 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BARD7_03030 ENOG4105XZU Preprotein translocase, subunit SecG BARD7_03034 ENOG4105KVH Transcriptional regulator BARD7_03039 ENOG4105DA5 (ABC) transporter BARD7_03040 ENOG4105R40 Glycine betaine carnitine choline BARD7_03041 ENOG4108HQR Glycine betaine BARD7_03042 ENOG4105E90 ABC transporter BARD7_03043 ENOG4108IJ8 ABC transporter BARD7_03044 ENOG4107HG4 Transcriptional regulator BARD7_03045 ENOG4105R40 Glycine betaine carnitine choline BARD7_03046 ENOG4108HQR Glycine betaine BARD7_03047 ENOG4105E90 ABC transporter BARD7_03048 ENOG4108IJ8 ABC transporter BARD7_03049 ENOG4107HG4 Transcriptional regulator BARD7_03050 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BARD7_03052 ENOG4105T65 Membrane-associated protein BARD7_03053 ENOG4108W0I acetyltransferase BARD7_03056 ENOG4105FJR Lmbe family BARD7_03060 ENOG4108IAJ Nad-dependent epimerase dehydratase BARD7_03061 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BARD7_03062 ENOG4107QQG Dehydrogenase BARD7_03063 ENOG4105IIU Aminopeptidase BARD7_03064 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BARD7_03065 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BARD7_03066 ENOG4105CP7 Triose-phosphate isomerase BARD7_03067 ENOG4105BZA Phosphoglycerate kinase BARD7_03068 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BARD7_03072 ENOG4105CMD Transcriptional regulator, GntR family BARD7_03073 ENOG4105DEN Luciferase family BARD7_03075 ENOG4105GZI Transcriptional regulator BARD7_03076 ENOG4107RT3 EamA-like transporter family BARD7_03079 ENOG4106KNT transcriptional regulator BARD7_03080 ENOG4105CMG Carbohydrate kinase BARD7_03081 ENOG4105C6Z Gluconate BARD7_03083 ENOG4107QR9 Iron-sulfur cluster binding protein BARD7_03084 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BARD7_03085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BARD7_03086 ENOG4105JXH GntR family transcriptional regulator BARD7_03087 ENOG4105DAA L-lactate BARD7_03088 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BARD7_03090 ENOG4108ZPC Polysaccharide pyruvyl transferase BARD7_03091 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BARD7_03092 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BARD7_03093 ENOG4105D3Q Sugar transferase BARD7_03095 ENOG4105K64 Glycosyl transferase, family 2 BARD7_03097 ENOG4107QRS glycosyltransferase group 2 family protein BARD7_03098 ENOG41068W6 Capsular polysaccharide biosynthesis protein BARD7_03099 ENOG4108KMV Glycosyl transferase (Group 1 BARD7_03100 ENOG4105K64 Glycosyl transferase, family 2 BARD7_03101 ENOG4108PQP glycosyl transferase group 1 BARD7_03103 ENOG4108QV3 biosynthesis protein BARD7_03104 ENOG4105HTX biosynthesis protein BARD7_03106 ENOG4105EBR Carboxylesterase BARD7_03107 ENOG4105NAE bifunctional deaminase-reductase domain protein BARD7_03108 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BARD7_03111 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BARD7_03112 ENOG4105PY6 Phenolic acid decarboxylase BARD7_03113 ENOG4105NI3 Protein of unknown function (DUF3237) BARD7_03120 ENOG4108HKT sucrose-6-phosphate hydrolase BARD7_03121 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BARD7_03122 ENOG4105ETE Transcriptional regulator (LacI family BARD7_03123 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BARD7_03124 ENOG4108KAM Transcriptional regulator BARD7_03125 ENOG4108KAM Transcriptional regulator BARD7_03127 ENOG4108URH decarboxylase BARD7_03128 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BARD7_03129 ENOG4105CHH sulfate transporter BARD7_03130 ENOG4108V2W Carbonate dehydratase BARD7_03131 ENOG4105C5I Dehydrogenase BARD7_03132 ENOG4105GGE ribonuclease BARD7_03133 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BARD7_03134 ENOG4105KRI phosphocarrier protein (HPr BARD7_03135 ENOG4105CIE May be required for sporulation (By similarity) BARD7_03136 ENOG4105CHW UPF0052 protein BARD7_03137 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BARD7_03138 ENOG4108Z4K mutator MutT protein BARD7_03139 ENOG4105C3M thioredoxin reductase BARD7_03142 ENOG4105BZU Histidine kinase BARD7_03143 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_03144 ENOG4105BZ1 (ABC) transporter BARD7_03145 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BARD7_03146 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BARD7_03147 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BARD7_03148 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BARD7_03149 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BARD7_03150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BARD7_03151 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BARD7_03152 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BARD7_03154 ENOG4108S4C acetyltransferase BARD7_03155 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BARD7_03157 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BARD7_03158 ENOG4105CE4 GlcNAc 6-P deacetylase BARD7_03159 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BARD7_03160 ENOG4105FDP GntR family transcriptional regulator BARD7_03162 ENOG4105J7D transcriptional regulator BARD7_03163 ENOG41088CQ domain protein BARD7_03164 ENOG41086DT Membrane protein of unknown function BARD7_03165 ENOG41067S9 phage shock protein C, PspC BARD7_03166 ENOG4108PY7 BARD7_03169 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BARD7_03170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BARD7_03173 ENOG4105MKU Transcriptional regulator BARD7_03178 ENOG4105CN1 protease BARD7_03179 ENOG4108M26 parallel beta-helix repeat protein BARD7_03180 ENOG4105CRP Part of the ABC transporter FtsEX involved in BARD7_03181 ENOG4105CAK Cell division ATP-binding protein ftsE BARD7_03184 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BARD7_03185 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BARD7_03186 ENOG4105MS2 ribosomal subunit Interface protein BARD7_03189 ENOG4105MQ3 flagellar protein FliS BARD7_03190 ENOG4107RT6 flagellar hook-associated BARD7_03191 ENOG4105I03 Flagellin BARD7_03192 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BARD7_03193 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BARD7_03195 ENOG4105DTJ flagellar hook-associated protein BARD7_03196 ENOG4105E1Q flagellar hook-associated protein BARD7_03199 ENOG4105RU3 BARD7_03200 ENOG41081UC Inherit from COG: Competence protein BARD7_03204 ENOG4105WH1 Two component transcriptional regulator luxr family BARD7_03205 ENOG4105BZU Histidine kinase BARD7_03206 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BARD7_03207 ENOG4108KGH TRANSCRIPTIONal BARD7_03208 ENOG4105ESV Glycosyl transferase, family 4 BARD7_03209 ENOG4107EF8 Glycosyl transferase (Group 1 BARD7_03212 ENOG4105QZI O-Antigen Polymerase BARD7_03213 ENOG4105C6Y Udp-glucose 6-dehydrogenase BARD7_03214 ENOG4107RA4 Glycosyl transferase (Group 1 BARD7_03215 ENOG4105PSV Polysaccharide Biosynthesis Protein BARD7_03216 ENOG4105D3Q Sugar transferase BARD7_03217 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BARD7_03218 ENOG4105JFG SpoIID LytB domain protein BARD7_03221 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BARD7_03222 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BARD7_03223 ENOG4105EY8 ABC transporter BARD7_03225 ENOG4107SJB teichoic acid biosynthesis BARD7_03226 ENOG41088M2 Glycosyl transferase family 2 BARD7_03227 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BARD7_03229 ENOG4107RZX Teichoic acid biosynthesis protein BARD7_03231 ENOG4105DG6 mannose-6-phosphate isomerase BARD7_03234 ENOG4108NHD germination protein BARD7_03235 ENOG4108SHN Glycosyl transferase, family 2 BARD7_03236 ENOG4105C54 Major Facilitator superfamily BARD7_03237 ENOG4108KGH TRANSCRIPTIONal BARD7_03238 ENOG4105J7I hydrolase BARD7_03239 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BARD7_03241 ENOG4105K4H Nlp p60 protein BARD7_03243 ENOG4105PNM synthesis protein BARD7_03245 ENOG4105N98 Capsule biosynthesis protein capB BARD7_03246 ENOG4105E1K spore germination protein BARD7_03249 ENOG4105ETE Transcriptional regulator (LacI family BARD7_03250 ENOG4108RVA ribokinase BARD7_03251 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BARD7_03252 ENOG4105C2J ABC transporter BARD7_03253 ENOG4105CNN ABC, transporter BARD7_03254 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BARD7_03256 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BARD7_03257 ENOG4107FQX Alpha-acetolactate decarboxylase BARD7_03259 ENOG4107RSM transcriptional regulator BARD7_03262 ENOG4106UIA BARD7_03265 ENOG4107XC4 flavin reductase domain protein, FMN-binding BARD7_03266 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BARD7_03268 ENOG4105CAH Chromate BARD7_03269 ENOG4105FGV Chromate BARD7_03270 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BARD7_03271 ENOG4106YAD MORN repeat variant BARD7_03275 ENOG4108XI2 Domain of unknown function (DUF1963) BARD7_03276 ENOG4105C6Y Udp-glucose 6-dehydrogenase BARD7_03277 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BARD7_03278 ENOG4107YJ4 chain length determinant protein BARD7_03279 ENOG4105HTX biosynthesis protein BARD7_03281 ENOG4105KBK Zinc finger, swim domain protein BARD7_03282 ENOG4105C0D helicase BARD7_03283 ENOG410667J hydrolase BARD7_03284 ENOG4105E98 transcriptional regulator DeoR family BARD7_03285 ENOG4105Z8H single-stranded DNA-binding protein BARD7_03288 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BARD7_03289 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BARD7_03291 ENOG4105CGA flagellar basal-body rod protein FlgG BARD7_03293 ENOG4105DFF Rod shape-determining protein mreb BARD7_03294 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BARD7_03295 ENOG4107MII Sugar-specific transcriptional regulator TrmB BARD7_03296 ENOG4105CZM Major Facilitator BARD7_03297 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BARD7_03298 ENOG41080V3 Major Facilitator superfamily BARD7_03299 ENOG4105D3W isochorismatase BARD7_03300 ENOG4105BZU Histidine kinase BARD7_03302 ENOG4105CNI cell division protein FtsW BARD7_03303 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BARD7_03305 ENOG4105FRN stage II sporulation protein BARD7_03306 ENOG4107TCE N-acetyltransferase BARD7_03309 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BARD7_03310 ENOG4106BRK BARD7_03311 ENOG4108RYK Nad-dependent epimerase dehydratase BARD7_03312 ENOG4108Z40 Transcriptional regulator BARD7_03313 ENOG4105CQM Urea amidohydrolase subunit alpha BARD7_03314 ENOG4105KI2 Urea amidohydrolase subunit beta BARD7_03315 ENOG4108YZ9 Urea amidohydrolase subunit gamma BARD7_03320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BARD7_03321 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BARD7_03323 ENOG4108TF4 von Willebrand factor, type A BARD7_03326 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BARD7_03328 ENOG4106778 Protein of unknown function (DUF1146) BARD7_03330 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BARD7_03331 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BARD7_03332 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BARD7_03333 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BARD7_03334 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BARD7_03337 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BARD7_03339 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BARD7_03340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BARD7_03341 ENOG4108UIC UPF0340 protein BARD7_03342 ENOG4108YZG isomerase BARD7_03343 ENOG4107WAU Protein tyrosine phosphatase BARD7_03344 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BARD7_03345 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BARD7_03347 ENOG4108ZXQ stage ii sporulation protein r BARD7_03349 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BARD7_03350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BARD7_03351 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BARD7_03353 ENOG4107TT2 Auxin Efflux Carrier BARD7_03354 ENOG4105C6K Malic enzyme BARD7_03355 ENOG4107104 thymidine kinase BARD7_03356 ENOG41082DI 50s ribosomal protein l31 BARD7_03357 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BARD7_03358 ENOG4105CBT Fructose-1,6-bisphosphatase BARD7_03359 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BARD7_03361 ENOG4105D2N Aldolase BARD7_03362 ENOG410812K response regulator receiver protein BARD7_03364 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BARD7_03366 ENOG4105DF6 Fe-S oxidoreductase BARD7_03368 ENOG4105E5J UV damage endonuclease BARD7_03370 ENOG4105BZ1 (ABC) transporter BARD7_03371 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BARD7_03373 ENOG4105R3A Nitrate reductase BARD7_03374 ENOG4108IUE nitrate reductase beta subunit BARD7_03378 ENOG4107V6Q Cyclic nucleotide-binding domain BARD7_03380 ENOG4105C75 arginyL-tRNA synthetase BARD7_03381 ENOG410684U Domain of unknown function (DUF1934) BARD7_03383 ENOG4107JM4 Tetratricopeptide repeat BARD7_03385 ENOG4105CYW agmatinase BARD7_03386 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BARD7_03387 ENOG4105BZ4 penicillin-binding protein BARD7_03389 ENOG4108XFG YwhD family BARD7_03390 ENOG4108Z4T Peptidase M50 BARD7_03391 ENOG41069HH 4-oxalocrotonate tautomerase BARD7_03392 ENOG41067TZ transcriptional regulator, MarR family BARD7_03393 ENOG4105CUB amino acid BARD7_03395 ENOG4105DCI Phosphohydrolase BARD7_03397 ENOG4108VCI transcription factor, rsfa family BARD7_03398 ENOG4105K7K Transcriptional regulator BARD7_03400 ENOG4105CJ1 ABC, transporter BARD7_03401 ENOG4108TU7 Inherit from COG: (ABC) transporter BARD7_03406 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BARD7_03407 ENOG4105DUM transcriptional regulator, lysR family BARD7_03408 ENOG4105HMI Membrane BARD7_03409 ENOG4108IJ2 phosphate acetyltransferase BARD7_03410 ENOG4107JTW chlorite dismutase BARD7_03412 ENOG4105CHM Aminotransferase BARD7_03414 ENOG4108M32 ATP-grasp domain BARD7_03417 ENOG41061WN bacilysin biosynthesis protein BARD7_03418 ENOG4105FCW Major Facilitator superfamily BARD7_03419 ENOG4105C2C drug resistance transporter, Bcr CflA BARD7_03422 ENOG4105C26 Dehydrogenase BARD7_03423 ENOG4105D82 Glutamate dehydrogenase BARD7_03425 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BARD7_03426 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BARD7_03427 ENOG4105C1B dTDP-glucose 4-6-dehydratase BARD7_03428 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BARD7_03429 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BARD7_03430 ENOG4107TY6 Acylneuraminate cytidylyltransferase BARD7_03432 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BARD7_03433 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BARD7_03440 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BARD7_03441 ENOG4108RJ9 Glycosyl transferase, family 2 BARD7_03443 ENOG4105DWF phosphomethylpyrimidine kinase BARD7_03446 ENOG4105C5Y PTS System BARD7_03449 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BARD7_03450 ENOG4105DEN Luciferase family BARD7_03451 ENOG4105D29 Helix-turn-helix type 11 domain protein BARD7_03452 ENOG4105CHR reductase BARD7_03455 ENOG4108DBC nitroreductase BARD7_03456 ENOG4105C19 ABC transporter BARD7_03461 ENOG4105I4A GCN5-related N-acetyltransferase BARD7_03463 ENOG41060D1 Quinol oxidase BARD7_03465 ENOG4105BZ9 Cytochrome C oxidase, subunit I BARD7_03466 ENOG4105E2S oxidase) subunit II BARD7_03467 ENOG4107BMA Transglycosylase associated protein BARD7_03469 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BARD7_03470 ENOG4105WH5 Teichoic acid glycosylation protein BARD7_03475 ENOG4107ZXU DSBA oxidoreductase BARD7_03476 ENOG4105DBE peroxidase BARD7_03477 ENOG410650H (LipO)protein BARD7_03478 ENOG4107SJW iron permease, FTR1 BARD7_03479 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BARD7_03480 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BARD7_03481 ENOG4105CMU LysR family (Transcriptional regulator BARD7_03482 ENOG4105VAW lrga family BARD7_03483 ENOG41067MG lrgb family BARD7_03485 ENOG4105DR4 Methyltransferase BARD7_03487 ENOG4105CK1 PTS System BARD7_03488 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BARD7_03489 ENOG4105X1N Glycosyl transferase family 8 BARD7_03490 ENOG4105GVJ transcriptional regulator BARD7_03491 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BARD7_03493 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BARD7_03495 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BARD7_03496 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BARD7_03497 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BARD7_03498 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BARD7_03499 ENOG4105CM2 brancheD-chain amino acid aminotransferase BARD7_03500 ENOG4105F8D glycoside hydrolase family 4 BARD7_03501 ENOG4105VCP PTS System BARD7_03502 ENOG4105CK1 PTS System BARD7_03503 ENOG4105VZJ PTS System BARD7_03504 ENOG4105EMD TRANSCRIPTIONal BARD7_03506 ENOG4105DQ5 transport system permease protein BARD7_03507 ENOG4105EHG Permease protein BARD7_03509 ENOG41082YX Transcriptional regulator, arsr family BARD7_03510 ENOG4107R5R arsenical pump membrane protein BARD7_03511 ENOG4105CH6 catalase BARD7_03512 ENOG4107QHE Choloylglycine hydrolase BARD7_03513 ENOG4105ETS cytosine purines uracil thiamine allantoin BARD7_03514 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BARD7_03515 ENOG4108JJ8 (ABC) transporter BARD7_03516 ENOG4108JJ9 ABC, transporter BARD7_03517 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BARD7_03518 ENOG4105C4M (Ubiquinol oxidase) subunit I BARD7_03519 ENOG4105D2K citrate carrier protein BARD7_03520 ENOG4107BJW polysaccharide deacetylase BARD7_03523 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BARD7_03526 ENOG4105CMR udp-glucose 4-epimerase BARD7_03527 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BARD7_03532 ENOG4105DHI Methyltransferase BARD7_03536 ENOG4105CH6 catalase BARD7_03537 ENOG4105D4T Citrate transporter BARD7_03539 ENOG4105CID antiterminator BARD7_03540 ENOG4105DEU major facilitator superfamily BARD7_03541 ENOG4105C1J atp-dependent rna helicase BARD7_03560 ENOG4108NR7 pectate lyase BARD7_03562 ENOG4107YZX Universal stress protein BARD7_03563 ENOG4105CS2 ec 3.2.1.21 BARD7_03567 ENOG4106Z5D Glycoside Hydrolase Family 43 BARD7_03569 ENOG4105C84 Histidine ammonia-lyase BARD7_03570 ENOG4105CGP Urocanate hydratase BARD7_03571 ENOG4105CI2 imidazolone-5-propionate hydrolase BARD7_03572 ENOG4107W25 arginase agmatinase formiminoglutamase BARD7_03575 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BARD7_03576 ENOG4105D9N nucleoside BARD7_03577 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BARD7_03578 ENOG4107RHR regulatoR BARD7_03579 ENOG410667J hydrolase BARD7_03586 ENOG4108V5C ABC transporter BARD7_03593 ENOG4105WZ4 isomerase BARD7_03594 ENOG4105F0H myo-inositol catabolism protein BARD7_03595 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BARD7_03597 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BARD7_03599 ENOG4105EDK PfkB domain protein BARD7_03601 ENOG4105C26 Dehydrogenase BARD7_03603 ENOG4105CPC Aldo Keto reductase BARD7_03604 ENOG4107QNK )-transporter BARD7_03605 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BARD7_03606 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BARD7_03607 ENOG4108S01 response regulator BARD7_03608 ENOG4108ZGX Histidine kinase BARD7_03609 ENOG4105ECK Fatty Acid Desaturase BARD7_03610 ENOG4105ST3 Transcriptional regulator BARD7_03611 ENOG4105C26 Dehydrogenase BARD7_03612 ENOG4108ITS PQQ enzyme repeat BARD7_03614 ENOG4105WAB arsR family transcriptional regulator BARD7_03615 ENOG4105F27 Major Facilitator BARD7_03616 ENOG41085PJ rdd domain containing protein BARD7_03618 ENOG4105D3R alkyl hydroperoxide reductase BARD7_03619 ENOG4108JU3 Alkyl hydroperoxide reductase BARD7_03621 ENOG4105C85 amino acid BARD7_03625 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BARD7_03626 ENOG4108XHQ (2Fe-2S)-binding domain protein BARD7_03630 ENOG4105XRQ Xanthine dehydrogenase accessory factor BARD7_03637 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BARD7_03641 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BARD7_03642 ENOG4105CPC Aldo Keto reductase BARD7_03643 ENOG4105WQG acetyltransferase BARD7_03646 ENOG41066UZ arginase EC 3.5.3.1 BARD7_03647 ENOG4108IQI permease BARD7_03648 ENOG4105C8Y Acetylornithine aminotransferase BARD7_03650 ENOG41082BM Transcriptional regulator, arsr family BARD7_03651 ENOG4108JUB Transcriptional regulator BARD7_03653 ENOG4105BZU Histidine kinase BARD7_03654 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_03655 ENOG4105C0H protease BARD7_03656 ENOG4105Q2H domain protein BARD7_03659 ENOG4105BZU Histidine kinase BARD7_03660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BARD7_03665 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BARD7_03666 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BARD7_03667 ENOG4105CDU Replicative dna helicase BARD7_03671 ENOG4105JNK Glycosyl transferase (Group 1 BARD7_03673 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BARD7_03674 ENOG4107QPH glycogen) synthase BARD7_03678 ENOG4105BZR domain protein BARD7_03679 ENOG4108XMW Membrane BARD7_03682 ENOG4105KVH Transcriptional regulator BARD7_03683 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BARD7_03684 ENOG4108UZ3 Transporter BARD7_03685 ENOG4105EDQ levansucrase EC 2.4.1.10 BARD7_03686 ENOG4108HKT sucrose-6-phosphate hydrolase BARD7_03690 ENOG4108TVJ Nitroreductase BARD7_03691 ENOG4105FS7 Transcriptional regulator BARD7_03693 ENOG4108U05 Transcriptional regulator BARD7_03694 ENOG41082BV acetyltransferase BARD7_03696 ENOG4107Y9U Membrane BARD7_03697 ENOG4105C7Z Conserved Protein BARD7_03698 ENOG4107FCW Abortive infection protein BARD7_03700 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BARD7_03702 ENOG4105CGK Exodeoxyribonuclease III BARD7_03703 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BARD7_03705 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BARD7_03706 ENOG4108UUM single-stranded DNA-binding protein BARD7_03707 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BARD7_03708 ENOG4105C3G gtp-binding protein BARD7_03709 ENOG4108J2R molybdopterin oxidoreductase BARD7_03710 ENOG4105VDK protein, conserved in bacteria BARD7_03712 ENOG4108ZDA Sporulation protein YyaC BARD7_03713 ENOG4105FA0 parb-like partition protein BARD7_03714 ENOG4107QJE Chromosome Partitioning Protein BARD7_03717 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BARD7_03718 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BARD7_03721 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)