locus-tag class description S101267_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) S101267_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S101267_00003 ENOG410848D S4 domain protein YaaA S101267_00004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) S101267_00006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101267_00007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101267_00014 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) S101267_00016 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) S101267_00017 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) S101267_00018 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) S101267_00019 ENOG4105BZW Glycerate kinase S101267_00021 ENOG4105ZMH deoxynucleoside kinase S101267_00023 ENOG4105VRS hydrolase family 18 S101267_00024 ENOG4105GTG Isochorismatase S101267_00025 ENOG4108Z6B deaminase S101267_00026 ENOG4105C6E dna polymerase iii S101267_00027 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) S101267_00028 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) S101267_00030 ENOG41067KS pro-sigma K processing S101267_00038 ENOG4105CDW Resistance protein S101267_00039 ENOG4105CXN decarboxylase S101267_00040 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) S101267_00041 ENOG4105X0R protein from nitrogen regulatory protein P-II S101267_00042 ENOG4105XVJ Protein of unknown function (DUF327) S101267_00043 ENOG4105FA2 dna polymerase iii S101267_00044 ENOG4105MA4 psp1 domain protein S101267_00046 ENOG41060K3 Methyltransferase S101267_00047 ENOG4105VC4 domain protein S101267_00048 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) S101267_00049 ENOG4105KRN Transcriptional regulator, abrb family S101267_00050 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) S101267_00051 ENOG4105F8V Hydrolase, tatD family S101267_00052 ENOG41069ER domain protein S101267_00054 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) S101267_00055 ENOG4105XFA sporulation peptidase YabG S101267_00056 ENOG4105W42 Veg protein S101267_00057 ENOG4105XEW small acid-soluble spore protein S101267_00058 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) S101267_00059 ENOG4105DFT pur operon repressor S101267_00060 ENOG4105KME endoribonuclease L-psp S101267_00061 ENOG4105K4W Could be involved in septation (By similarity) S101267_00062 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) S101267_00063 ENOG4105C5T Phosphoribosyl pyrophosphate synthase S101267_00064 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) S101267_00067 ENOG4108JA2 transcriptioN-repair coupling factor S101267_00068 ENOG4108M14 stage v sporulation protein t S101267_00070 ENOG4108IY2 MazG family S101267_00071 ENOG41082I2 s4 domain protein S101267_00072 ENOG4105VYY sporulation protein yabp S101267_00075 ENOG41060GV RNA binding s1 domain protein S101267_00081 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) S101267_00082 ENOG4108UGV hypoxanthine phosphoribosyltransferase S101267_00083 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S101267_00084 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) S101267_00085 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) S101267_00086 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S101267_00087 ENOG4105C6T cysteine synthase S101267_00088 ENOG4105CRQ synthase (Component I) S101267_00089 ENOG4105DDQ anthranilate synthase S101267_00090 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 S101267_00091 ENOG4105EEI dihydropteroate synthase S101267_00092 ENOG4105KRF dihydroneopterin aldolase S101267_00093 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase S101267_00095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) S101267_00096 ENOG4105CRK lysyL-tRNA synthetase S101267_00113 ENOG4108Z0C Uvrb UvrC protein S101267_00114 ENOG41066A3 ATP guanido phosphotransferase S101267_00116 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) S101267_00117 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) S101267_00118 ENOG4105CTP PilT protein domain protein S101267_00119 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) S101267_00120 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) S101267_00121 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) S101267_00122 ENOG4105D7W serine acetyltransferase S101267_00124 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) S101267_00125 ENOG4105C2N RNA methyltransferase TrmH family group 3 S101267_00126 ENOG4105M0M Tetracycline resistance protein S101267_00129 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) S101267_00130 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) S101267_00132 ENOG4108VZM 50s ribosomal protein L10 S101267_00133 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) S101267_00134 ENOG4107Y49 methyltransferase S101267_00135 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101267_00136 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101267_00137 ENOG4105XPM ribosomal protein S101267_00138 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) S101267_00139 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) S101267_00140 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S101267_00141 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) S101267_00142 ENOG4107SKW Inherit from COG: Alpha beta hydrolase S101267_00143 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) S101267_00144 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) S101267_00145 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) S101267_00146 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) S101267_00147 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity S101267_00148 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) S101267_00149 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) S101267_00150 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) S101267_00151 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) S101267_00152 ENOG41082SA 50s ribosomal protein l29 S101267_00153 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal S101267_00154 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) S101267_00156 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits S101267_00158 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) S101267_00159 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) S101267_00160 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) S101267_00161 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) S101267_00162 ENOG4105VPB 50S ribosomal protein L30 S101267_00163 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) S101267_00164 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) S101267_00165 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) S101267_00166 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) S101267_00167 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) S101267_00169 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits S101267_00170 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) S101267_00171 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101267_00172 ENOG4108ZT0 50S ribosomal protein l17 S101267_00173 ENOG4108JJB ABC transporter S101267_00174 ENOG4108JJB ABC transporter S101267_00175 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) S101267_00176 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) S101267_00177 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) S101267_00178 ENOG4108UJD 30S ribosomal protein S9 S101267_00179 ENOG4108I0C methyltransferase S101267_00183 ENOG4105D1F ATP-binding protein S101267_00186 ENOG4108NMV polysaccharide deacetylase S101267_00199 ENOG4108JPW Aminotransferase S101267_00201 ENOG4105CPQ Dehydrogenase S101267_00202 ENOG4105CHH sulfate transporter S101267_00204 ENOG4108SA1 esterase S101267_00208 ENOG410874W AraC family transcriptional regulator S101267_00209 ENOG4105EHZ conserved protein UCP016719 S101267_00210 ENOG4105D17 glycoside hydrolase, family 3 domain protein S101267_00213 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S101267_00215 ENOG4105EWC Purine nucleoside phosphorylase S101267_00221 ENOG4105EMN RNA polymerase sigma factor S101267_00223 ENOG4105C8B TIGR00159 family S101267_00224 ENOG4107U5W ybbr family S101267_00225 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) S101267_00231 ENOG4106K80 S101267_00233 ENOG41067MG lrgb family S101267_00235 ENOG41061AU MarR family Transcriptional regulator S101267_00238 ENOG4105BZU Histidine kinase S101267_00239 ENOG4105WH1 Two component transcriptional regulator luxr family S101267_00240 ENOG4105CJ1 ABC, transporter S101267_00242 ENOG41090VJ ABC-2 type transporter S101267_00245 ENOG4106DDH Sporulation-specific SASP protein S101267_00248 ENOG4107QTZ amino acid S101267_00250 ENOG4107VXM glycerophosphoryl diester phosphodiesterase S101267_00251 ENOG4105CXY transporter S101267_00256 ENOG4107SCQ Iron-containing alcohol dehydrogenase S101267_00257 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR S101267_00258 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase S101267_00259 ENOG4107ZTW SNARE associated Golgi S101267_00262 ENOG4105C72 UPF0176 protein S101267_00264 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101267_00265 ENOG4108IQI permease S101267_00266 ENOG4108J5H Homocysteine s-methyltransferase S101267_00268 ENOG4105CSV Glutaminase S101267_00269 ENOG4105CSV Glutaminase S101267_00274 ENOG41076HS cation diffusion facilitator family transporter S101267_00275 ENOG4108TVJ Nitroreductase S101267_00276 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase S101267_00277 ENOG4108VGI doxx family S101267_00278 ENOG4105XXY Thioredoxin S101267_00282 ENOG4105DGI Alkaline phosphatase S101267_00283 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101267_00284 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101267_00285 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) S101267_00286 ENOG4107EPV Aminotransferase class V S101267_00287 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101267_00288 ENOG4105J7D transcriptional regulator S101267_00289 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S101267_00290 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S101267_00291 ENOG41060AI SEC-C motif S101267_00292 ENOG4107SET aldo keto reductase S101267_00298 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101267_00301 ENOG4105U3E Transcriptional regulator S101267_00302 ENOG4105DSE periplasmic solute binding protein S101267_00303 ENOG4105DIK (ABC) transporter S101267_00305 ENOG4105DEN Luciferase family S101267_00306 ENOG4108N0M stress protein S101267_00307 ENOG4106FN3 tellurium resistance protein S101267_00308 ENOG4106FN3 tellurium resistance protein S101267_00309 ENOG4107TS3 membrane protein, TerC S101267_00310 ENOG4108TTB tellurium resistance protein S101267_00312 ENOG41079KZ Major Facilitator Superfamily S101267_00314 ENOG4108IJ7 Glycine betaine S101267_00315 ENOG4107SQ8 Glycine betaine S101267_00322 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S101267_00330 ENOG4105EIG urea carboxylase-associated protein 1 S101267_00331 ENOG4107RA1 nh(3)-dependent nad( ) synthetase S101267_00332 ENOG4108WBH protein TIM barrel S101267_00333 ENOG4105DJB Major Facilitator Superfamily S101267_00334 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) S101267_00335 ENOG4105I82 acetyl xylan esterase S101267_00336 ENOG410756H nucleotidyltransferase S101267_00338 ENOG4105C26 Dehydrogenase S101267_00339 ENOG4105CK7 Sodium proline symporter S101267_00340 ENOG4107YHD transcriptional regulator S101267_00341 ENOG4105CAY ferredoxin--nadp reductase S101267_00342 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101267_00343 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit S101267_00344 ENOG4108IFG nitrite reductase, (NAD(P)H) S101267_00346 ENOG4105CKI cobalamin synthesis protein S101267_00347 ENOG4105E2A Dehydrogenase S101267_00348 ENOG4105HHM rdd domain containing protein S101267_00350 ENOG4105CS2 ec 3.2.1.21 S101267_00353 ENOG41080HJ 6-phospho 3-hexuloisomerase S101267_00354 ENOG4108VA3 3-hexulose-6-phosphate synthase S101267_00355 ENOG4105KVH Transcriptional regulator S101267_00356 ENOG4105CEY Amp-dependent synthetase and ligase S101267_00360 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) S101267_00363 ENOG4105CDA abc transporter atp-binding protein S101267_00364 ENOG4105DRP amino acid AbC transporter S101267_00366 ENOG4106P55 Transcriptional regulator S101267_00367 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase S101267_00368 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) S101267_00369 ENOG41069ZX S101267_00370 ENOG41069ZX S101267_00371 ENOG4105DUX Transporter S101267_00374 ENOG4105E1K spore germination protein S101267_00377 ENOG4105CPU Monooxygenase S101267_00378 ENOG4108XSB acetyltransferase, (GNAT) family S101267_00379 ENOG4105EAB amino acid AbC transporter S101267_00380 ENOG4108HW4 amino acid AbC transporter S101267_00382 ENOG4105CH2 amidohydrolase S101267_00383 ENOG4108PGP mmge prpd family protein S101267_00385 ENOG4107WD8 ABC transporter, permease S101267_00386 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_00387 ENOG4105BZU Histidine kinase S101267_00391 ENOG4105CFH Aspartokinase S101267_00392 ENOG4105DHS permease protein S101267_00393 ENOG4105CM4 permease protein S101267_00394 ENOG4108IPW abc transporter atp-binding protein S101267_00397 ENOG4105R8C Transcriptional regulator S101267_00398 ENOG4108DBC nitroreductase S101267_00399 ENOG41067V3 Antibiotic biosynthesis monooxygenase S101267_00400 ENOG4105YVS arsR family transcriptional regulator S101267_00402 ENOG4108JPW Aminotransferase S101267_00403 ENOG4105C26 Dehydrogenase S101267_00405 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101267_00406 ENOG4105KTB nuclear export factor GLE1 S101267_00407 ENOG4108T5E Copper resistance protein S101267_00408 ENOG4108ZYE Transcriptional regulator S101267_00412 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase S101267_00416 ENOG4105E7W lamb ycsf family protein S101267_00417 ENOG4105C5A transporter S101267_00418 ENOG4105CFM UPF0317 protein S101267_00419 ENOG4105P4J Allophanate hydrolase, subunit 1 S101267_00421 ENOG4107258 Transcriptional regulator S101267_00422 ENOG4105XJB lipolytic protein G-D-S-L family S101267_00424 ENOG41061CK Antibiotic biosynthesis monooxygenase S101267_00425 ENOG4107RVG penicillin-binding protein S101267_00426 ENOG4107QM2 Aldo Keto reductase S101267_00427 ENOG4105ETD TRANSCRIPTIONal S101267_00429 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101267_00432 ENOG410606W general stress protein S101267_00434 ENOG4105VCH membrane S101267_00436 ENOG4105C9U ATP-dependent DNA helicase RecQ S101267_00439 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S101267_00440 ENOG4107R8N Glycosyl transferase, family 2 S101267_00442 ENOG4105C0X amino acid S101267_00451 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) S101267_00454 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) S101267_00455 ENOG4105RXJ S101267_00456 ENOG4105KPY Small multidrug resistance protein S101267_00457 ENOG4105EU9 S101267_00458 ENOG4105QVS general stress protein S101267_00459 ENOG41082W1 Cupin 2, conserved barrel domain protein S101267_00462 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit S101267_00463 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit S101267_00464 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism S101267_00465 ENOG4108MRH transcriptional regulatory protein S101267_00466 ENOG4107QJT sodium dicarboxylate symporter S101267_00467 ENOG4106F5Q Membrane S101267_00468 ENOG4105CJ1 ABC, transporter S101267_00471 ENOG4105FDT acyl-CoA dehydrogenase S101267_00475 ENOG4105SZ6 Thioredoxin S101267_00476 ENOG4105CPF Cell wall formation (By similarity) S101267_00477 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) S101267_00478 ENOG4105C1J atp-dependent rna helicase S101267_00479 ENOG410905X membrane-flanked domain protein S101267_00480 ENOG4105CKV Membrane S101267_00482 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) S101267_00483 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein S101267_00484 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101267_00486 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) S101267_00487 ENOG4107MMM Anti-sigma-factor antagonist S101267_00488 ENOG4105FUA antagonist S101267_00489 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase S101267_00490 ENOG4107SGM protein serine threonine phosphatase S101267_00491 ENOG4105WN5 stage II sporulation protein S101267_00492 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S101267_00494 ENOG41064BQ Phosphatase S101267_00497 ENOG410906U SprT-like S101267_00506 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_00510 ENOG4106DF4 Sigma-70, region 4 S101267_00514 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) S101267_00515 ENOG41068WC Domain of unknown function (DUF955) S101267_00516 ENOG4108IMY Transcriptional regulator S101267_00520 ENOG4108RYM conjugative transposon protein S101267_00522 ENOG4106BHR ftsk SpoIIIE family protein S101267_00523 ENOG4106128 DNA-binding helix-turn-helix protein S101267_00535 ENOG4105P1M Domain of unknown function (DUF1874) S101267_00537 ENOG4105K4H Nlp p60 protein S101267_00547 ENOG4106ANW SMI1_KNR4 S101267_00548 ENOG4106BHF S101267_00550 ENOG410847I Transcriptional regulator, BadM Rrf2 family S101267_00552 ENOG4105VEQ Cold shock protein S101267_00556 ENOG4107U9B transcriptional regulator S101267_00557 ENOG4105DXI Major Facilitator superfamily S101267_00558 ENOG4105IRW patatin-like phospholipase family protein S101267_00559 ENOG4105IRW patatin-like phospholipase family protein S101267_00561 ENOG4105DNP FAD linked oxidase domain protein S101267_00563 ENOG4105PGM cation diffusion facilitator family transporter S101267_00565 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein S101267_00566 ENOG4108U7W acetyltransferase S101267_00567 ENOG41086D8 Transcriptional regulator S101267_00572 ENOG4105DQ4 alcohol dehydrogenase S101267_00573 ENOG4105VUF Transcriptional regulator S101267_00575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101267_00577 ENOG4105EQ0 Major Facilitator superfamily S101267_00578 ENOG4108JGH Tetr family transcriptional regulator S101267_00579 ENOG4105T38 integral membrane protein S101267_00580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101267_00583 ENOG4105E2A Dehydrogenase S101267_00584 ENOG4105PGS Spore coat protein S101267_00586 ENOG4105EYF MMPL domain protein S101267_00590 ENOG4108JYZ YitT family S101267_00592 ENOG4105C2C drug resistance transporter, Bcr CflA S101267_00593 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101267_00597 ENOG41090E6 transcriptional regulator MERR family S101267_00600 ENOG4105EBM Alpha Beta Hydrolase Fold protein S101267_00601 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101267_00602 ENOG4105DRR Transcriptional regulator, GntR family S101267_00606 ENOG4105FQP Beta-lactamase S101267_00608 ENOG41090UD (LipO)protein S101267_00609 ENOG4108SUT Major Facilitator Superfamily S101267_00610 ENOG4108TZY GntR Family Transcriptional Regulator S101267_00611 ENOG4105JXH GntR family transcriptional regulator S101267_00612 ENOG4105DJ2 Major Facilitator Superfamily S101267_00616 ENOG4107QTZ amino acid S101267_00620 ENOG4107QNK )-transporter S101267_00628 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) S101267_00629 ENOG4105K8N protein family UPF0079, ATPase S101267_00630 ENOG41072GX Peptidase M22 Glycoprotease S101267_00631 ENOG410801F ribosomal-protein-alanine acetyltransferase S101267_00632 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101267_00633 ENOG4105C5H ABC transporter S101267_00634 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S101267_00635 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) S101267_00636 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101267_00637 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101267_00639 ENOG4108TYN CAAX amino terminal protease family protein S101267_00640 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) S101267_00641 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) S101267_00654 ENOG4108NF7 phage-type endonuclease S101267_00655 ENOG4108PNI recT protein S101267_00684 ENOG4105IG6 Phage terminase, large subunit S101267_00706 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101267_00709 ENOG4105ESF Peptidoglycan binding domain protein S101267_00712 ENOG4105PGZ NB-ARC domain S101267_00713 ENOG4105CPQ Dehydrogenase S101267_00714 ENOG4105CT4 transporter S101267_00717 ENOG41087YS Phage shock protein A S101267_00718 ENOG4105DQX Zinc finger domain S101267_00719 ENOG4108WV1 Pfam:DUF477 S101267_00721 ENOG4105EXC Acyl-transferase S101267_00722 ENOG4108P49 AntiSigma factor S101267_00723 ENOG4105JVQ RNA Polymerase S101267_00729 ENOG4107STQ Multicopper oxidase S101267_00730 ENOG4105C85 amino acid S101267_00732 ENOG4105C7R Atpase associated with various cellular activities aaa_3 S101267_00735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) S101267_00738 ENOG4105C7N Xanthine uracil vitamin C permease S101267_00743 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) S101267_00744 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit S101267_00745 ENOG4105C83 adenylosuccinate lyase S101267_00746 ENOG4105C8V SAICAR synthetase S101267_00747 ENOG4105VR9 phosphoribosylformylglycinamidine synthase S101267_00748 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I S101267_00749 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii S101267_00751 ENOG4105CXB phosphoribosylaminoimidazole synthetase S101267_00752 ENOG4108V3E phosphoribosylglycinamide formyltransferase S101267_00753 ENOG4105DC1 bifunctional purine biosynthesis protein purh S101267_00754 ENOG4105C12 Phosphoribosylglycinamide synthetase S101267_00756 ENOG4105DVH amino acid S101267_00759 ENOG4108R5T secreted protein S101267_00760 ENOG4105KGF protein, YerC YecD S101267_00761 ENOG4105CBC glutamate synthase S101267_00763 ENOG4105C4R Atp-dependent dna helicase S101267_00764 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) S101267_00766 ENOG4105CRN Aminoglycoside phosphotransferase S101267_00767 ENOG4105KT7 mgtC SapB transporter S101267_00768 ENOG4105CK7 Sodium proline symporter S101267_00769 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101267_00770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S101267_00771 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101267_00772 ENOG4108IG5 Transcriptional regulator S101267_00774 ENOG4105CBD Diacylglycerol kinase S101267_00775 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101267_00777 ENOG4105CJ1 ABC, transporter S101267_00783 ENOG4106BHF S101267_00784 ENOG4105CDY transcriptional regulatory protein S101267_00786 ENOG41075D4 Aminoglycoside 6-adenylyltransferase S101267_00789 ENOG4105WEF catalase S101267_00790 ENOG4105M18 -acetyltransferase S101267_00792 ENOG4105H67 Protein of unknown function (DUF421) S101267_00793 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) S101267_00794 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily S101267_00798 ENOG4106I4J membrane S101267_00799 ENOG41082F9 transcriptional regulator S101267_00800 ENOG41061H0 Monooxygenase S101267_00801 ENOG4108R1P S101267_00802 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101267_00804 ENOG4105E0M Sulfatase S101267_00805 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase S101267_00807 ENOG41090R9 glycosyltransferase S101267_00808 ENOG4107R51 Glycosyl transferase, family 2 S101267_00809 ENOG41090R9 glycosyltransferase S101267_00810 ENOG4105EU0 Major facilitator Superfamily S101267_00811 ENOG4105CUB amino acid S101267_00812 ENOG4105C26 Dehydrogenase S101267_00813 ENOG4105FKZ Methyl-accepting chemotaxis S101267_00814 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101267_00815 ENOG4107TVC Glycosyl transferase, family 2 S101267_00816 ENOG4105C5H ABC transporter S101267_00817 ENOG4107SWG transcriptional regulator MERR family S101267_00818 ENOG4105DXB Major Facilitator superfamily S101267_00819 ENOG4105C5H ABC transporter S101267_00820 ENOG4105FDU atp-dependent rna helicase S101267_00821 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101267_00822 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101267_00825 ENOG4108J20 pectate lyase S101267_00826 ENOG4107QPK )-transporter S101267_00832 ENOG4108NEV two component transcriptional regulator, LytTR family S101267_00834 ENOG4108Z6X (sortase) family S101267_00836 ENOG4108MRH transcriptional regulatory protein S101267_00841 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) S101267_00842 ENOG4108RPX mosc domain containing protein S101267_00846 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) S101267_00854 ENOG4105C5Y PTS System S101267_00855 ENOG4105CG3 alpha amylase, catalytic region S101267_00856 ENOG4107414 GntR family transcriptional regulator S101267_00857 ENOG4108RCM Nitroreductase S101267_00860 ENOG4105CGH 5'-nucleotidase S101267_00861 ENOG4107RKG DJ-1/PfpI family S101267_00862 ENOG4105ETE Transcriptional regulator (LacI family S101267_00863 ENOG4105E2X shikimate dehydrogenase S101267_00864 ENOG4105FF2 Type I DHQase S101267_00867 ENOG4105KJF protein tyrosine phosphatase S101267_00869 ENOG4107U9T Pfam:Ribonuclease_BN S101267_00870 ENOG4108ISG Major Facilitator S101267_00871 ENOG4105UPD Calcium Proton S101267_00873 ENOG4105D8X mechanosensitive ion channel S101267_00877 ENOG4106KE4 Dehydrogenase S101267_00878 ENOG4106KE4 Dehydrogenase S101267_00880 ENOG4105D7N magnesium and cobalt transport protein CorA S101267_00882 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101267_00884 ENOG4105BZ1 (ABC) transporter S101267_00885 ENOG4105CJA serine threonine protein kinase S101267_00897 ENOG4107RUY (E1 component), alpha subunit S101267_00899 ENOG4107QKR Dehydrogenase S101267_00901 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S101267_00902 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S101267_00904 ENOG4105F8D glycoside hydrolase family 4 S101267_00905 ENOG4108Q3X Transcriptional regulator S101267_00906 ENOG4105CI1 PTS System S101267_00908 ENOG4105BZ1 (ABC) transporter S101267_00909 ENOG4105BZ1 (ABC) transporter S101267_00911 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase S101267_00912 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101267_00913 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101267_00914 ENOG4105U3E Transcriptional regulator S101267_00915 ENOG4105DYS nad(p)h dehydrogenase (quinone) S101267_00916 ENOG4105H93 Acyltransferase family S101267_00918 ENOG4108YYS metal-dependent hydrolase (By similarity) S101267_00919 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101267_00920 ENOG410834F Transcriptional regulator S101267_00922 ENOG4105JAB phenazine biosynthesis protein, phzf family S101267_00923 ENOG4107Y03 Nitroreductase S101267_00926 ENOG4105ECP epimerase S101267_00927 ENOG410902V Modulates RecA activity (By similarity) S101267_00929 ENOG4105F27 Major Facilitator S101267_00931 ENOG4108TCS Glutamyl endopeptidase S101267_00934 ENOG4106AKJ S101267_00935 ENOG4105D74 hydrolase S101267_00936 ENOG4105CKK Glycosyl transferase, family 2 S101267_00937 ENOG4105EJV Membrane S101267_00938 ENOG41067AE Membrane-bound metal-dependent hydrolase S101267_00939 ENOG4105CEN a g-specific adenine glycosylase S101267_00940 ENOG4106BXE S101267_00941 ENOG4105CAN Short-chain dehydrogenase reductase Sdr S101267_00945 ENOG4105BZ1 (ABC) transporter S101267_00946 ENOG4107NBY Membrane S101267_00947 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S101267_00948 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101267_00949 ENOG4105G5W regulator Fur family S101267_00950 ENOG4105TUA UPF0295 protein S101267_00997 ENOG410682Q Phage transcriptional regulator, ArpU S101267_00999 ENOG4105CNU cell division protein FtsK S101267_01007 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101267_01017 ENOG4108FKH Transglycosylase SLT domain S101267_01021 ENOG41068G1 S101267_01025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S101267_01029 ENOG4107S6Z Na H antiporter S101267_01030 ENOG4105EC3 peptidase S51, dipeptidase E S101267_01031 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) S101267_01032 ENOG4105DNP FAD linked oxidase domain protein S101267_01034 ENOG4105DEF Extracellular solute-binding protein, family 5 S101267_01036 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101267_01037 ENOG4105C3U ABC transporter S101267_01041 ENOG4105E2Y ABC, transporter S101267_01042 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein S101267_01043 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S101267_01046 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101267_01047 ENOG4107D63 S101267_01048 ENOG4105VZ8 Transcriptional regulator S101267_01051 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) S101267_01053 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) S101267_01058 ENOG4105CYN Serine protein kinase S101267_01060 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes S101267_01061 ENOG4105CW7 secretion protein, HlyD family S101267_01062 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101267_01063 ENOG4105CS1 NAD(P)H quinone oxidoreductase S101267_01066 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family S101267_01067 ENOG4105CZV ABC transporter S101267_01068 ENOG4105CJ1 ABC, transporter S101267_01069 ENOG4108TU7 Inherit from COG: (ABC) transporter S101267_01070 ENOG4105VEQ Cold shock protein S101267_01072 ENOG4105BZU Histidine kinase S101267_01074 ENOG4105CE7 Amidase, hydantoinase carbamoylase family S101267_01081 ENOG4108YBP pseudouridine synthase S101267_01083 ENOG41080XP Cbs domain S101267_01084 ENOG4107YBY Hydrolase S101267_01085 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101267_01086 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101267_01087 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator S101267_01089 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S101267_01090 ENOG4105C6V Glycerol-3-phosphate dehydrogenase S101267_01092 ENOG4105BZU Histidine kinase S101267_01093 ENOG4105WH1 Two component transcriptional regulator luxr family S101267_01100 ENOG4105ED1 spovr family S101267_01101 ENOG4105G6Z alkaline phosphatase S101267_01104 ENOG4105BZN citrate synthase S101267_01105 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101267_01106 ENOG4105CUB amino acid S101267_01107 ENOG4105C8J )-transporter S101267_01109 ENOG4105J37 S101267_01110 ENOG4108AEY RNA polymerase sigma factor S101267_01111 ENOG4105F6E Acyl-transferase S101267_01112 ENOG4105C37 (CBS) domain S101267_01114 ENOG4105CHM Aminotransferase S101267_01115 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase S101267_01116 ENOG4105C37 (CBS) domain S101267_01118 ENOG4105WMR Protein CrcB homolog S101267_01119 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101267_01121 ENOG4105D64 Mechanosensitive ion channel S101267_01122 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) S101267_01123 ENOG4107VMI polysaccharide deacetylase S101267_01124 ENOG4105F0I Aminotransferase S101267_01125 ENOG4105W1N transcriptional regulator S101267_01126 ENOG4105IIP Membrane S101267_01128 ENOG4105BZ1 (ABC) transporter S101267_01129 ENOG4105BZ1 (ABC) transporter S101267_01134 ENOG410839P S101267_01136 ENOG4106MP8 UPF0754 membrane protein S101267_01137 ENOG4105WZB UPF0342 protein S101267_01139 ENOG4105D4P Coproporphyrinogen iii oxidase S101267_01141 ENOG4107S91 Sodium hydrogen exchanger S101267_01142 ENOG4105NCW Trka-c domain protein S101267_01144 ENOG4105CGU Enoyl-CoA hydratase S101267_01146 ENOG4108IUX (ABC) transporter S101267_01147 ENOG4105RHA ABC transporter, permease S101267_01148 ENOG4107VRP DNA repair exonuclease S101267_01149 ENOG4106D4I domain protein S101267_01150 ENOG4105EQI Metal Dependent Phosphohydrolase S101267_01152 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S101267_01158 ENOG4105NBU tryptophan transport protein S101267_01159 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) S101267_01160 ENOG4105K59 histidine triad (HIT) protein S101267_01166 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation S101267_01167 ENOG4105BZ4 penicillin-binding protein S101267_01168 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) S101267_01169 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S101267_01170 ENOG4105C1Q protoporphyrinogen oxidase S101267_01172 ENOG4105ECB domain protein S101267_01175 ENOG4105DER m42 family S101267_01177 ENOG4108RQ5 Beta-lactamase domain-containing protein S101267_01178 ENOG4105DF9 Lipoate-protein, ligase S101267_01180 ENOG4105CEY Amp-dependent synthetase and ligase S101267_01182 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 S101267_01184 ENOG4108HUF Transporter S101267_01185 ENOG4107TB6 phosphoglycerate mutase S101267_01187 ENOG4107F3J Amp-dependent synthetase and ligase S101267_01188 ENOG4107ZYJ bioY protein S101267_01189 ENOG4106YBV Methyl-accepting chemotaxis S101267_01193 ENOG4105XVF Competence transcription factor S101267_01194 ENOG4108ZMX Domain of unknown function (DU1801) S101267_01197 ENOG4105X3H Excalibur domain protein S101267_01198 ENOG4105K8R UPF0145 protein S101267_01199 ENOG4105E1V na solute symporter S101267_01200 ENOG4106CAD Protein of unknown function (DUF3311) S101267_01201 ENOG41060YP S101267_01204 ENOG4107SCK Monooxygenase S101267_01205 ENOG4108INS Transcriptional regulator S101267_01206 ENOG4108KK1 membrane protein AbrB duplication S101267_01208 ENOG4108IG5 Transcriptional regulator S101267_01210 ENOG4108QY0 Membrane S101267_01211 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination S101267_01212 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation S101267_01214 ENOG4105EYH Exonuclease S101267_01223 ENOG4105ERH Fumarylacetoacetate hydrolase S101267_01225 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101267_01227 ENOG4105CAQ asparagine synthetase S101267_01229 ENOG4105UQX Mate efflux family protein S101267_01230 ENOG4106HBX Transcriptional Regulator AraC Family S101267_01231 ENOG4105ETE Transcriptional regulator (LacI family S101267_01232 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101267_01233 ENOG4105SF0 DinB family S101267_01234 ENOG4108ZUB Lysine exporter protein (Lyse ygga) S101267_01235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101267_01236 ENOG4105MYW Pentapeptide repeat protein S101267_01237 ENOG4105MA6 gCN5-related N-acetyltransferase S101267_01239 ENOG4108VPT UPF0234 protein S101267_01240 ENOG4105QNR S1 RNA binding domain protein S101267_01241 ENOG4105DIH basic membrane S101267_01242 ENOG4105C8Q Methyl-accepting chemotaxis S101267_01243 ENOG4107E6A Cytochrome p-450 S101267_01244 ENOG4105EPR degv family S101267_01245 ENOG4107AYK membrAne S101267_01247 ENOG41073B9 S101267_01249 ENOG4108KP7 hydrolase S101267_01250 ENOG4108MXZ Esterase S101267_01251 ENOG4105VG1 fes assembly suf system protein S101267_01252 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) S101267_01253 ENOG4105IQ5 FAD linked oxidase domain protein S101267_01255 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase S101267_01257 ENOG4105CAS nag kinase S101267_01258 ENOG4105C8Y Acetylornithine aminotransferase S101267_01259 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101267_01261 ENOG4105DBV ornithine carbamoyltransferase S101267_01266 ENOG4107RMD Basic membrane lipoprotein S101267_01269 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) S101267_01270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101267_01272 ENOG4105C3U ABC transporter S101267_01273 ENOG4108JQ7 (ABC) transporter S101267_01276 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101267_01278 ENOG4105C31 Tryptophanyl-tRNA synthetase S101267_01279 ENOG4108J59 Extracellular solute-binding protein, family 5 S101267_01280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101267_01281 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101267_01283 ENOG4108JQ7 (ABC) transporter S101267_01286 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) S101267_01287 ENOG4108ZCF integral membrane protein S101267_01288 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis S101267_01290 ENOG4105DPN Oligoendopeptidase f S101267_01292 ENOG4105T58 Dithiol-disulfide isomerase S101267_01293 ENOG4108Z18 K06886 hemoglobin S101267_01294 ENOG4105E4C Lytic transglycosylase catalytic S101267_01295 ENOG4105MIX Adenylate cyclase S101267_01298 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S101267_01299 ENOG4105EMS pseudouridine synthase S101267_01300 ENOG4107S1Q Phosphatase S101267_01302 ENOG4105ETU transcriptional activator (TenA S101267_01303 ENOG4108VEU Thiamine monophosphate synthase S101267_01307 ENOG4105D06 uba thif-type nad fad binding protein S101267_01308 ENOG4105DWF phosphomethylpyrimidine kinase S101267_01309 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH S101267_01310 ENOG4107A88 S101267_01321 ENOG4105ENA helicase S101267_01325 ENOG4105CJ1 ABC, transporter S101267_01328 ENOG4108ZMI UPF0477 protein S101267_01330 ENOG4105C28 cystathionine S101267_01331 ENOG4105C28 cystathionine S101267_01333 ENOG4105VTR Integrase S101267_01343 ENOG4105ZUG S101267_01364 ENOG4105E4C Lytic transglycosylase catalytic S101267_01386 ENOG4105EKQ RNA-directed DNA polymerase S101267_01387 ENOG4105DB4 S101267_01388 ENOG4105DB4 S101267_01389 ENOG4105DB4 S101267_01392 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101267_01402 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101267_01405 ENOG4105CK1 PTS System S101267_01406 ENOG4105VCP PTS System S101267_01407 ENOG4105CS2 ec 3.2.1.21 S101267_01408 ENOG4105E98 transcriptional regulator DeoR family S101267_01412 ENOG4105KT7 mgtC SapB transporter S101267_01417 ENOG4108IEG Formate dehydrogenase Alpha subunit S101267_01418 ENOG4105C4B ABC transporter, permease S101267_01419 ENOG4105EXQ uroporphyrinogen iii synthase hem4 S101267_01421 ENOG41087PP glycosyltransferase MGT family S101267_01422 ENOG4106A3M Cytochrome p-450 S101267_01424 ENOG4108IEG Formate dehydrogenase Alpha subunit S101267_01425 ENOG4108IXI (ABC) transporter S101267_01427 ENOG4105Q95 Cupin 2, conserved barrel domain protein S101267_01430 ENOG4105D2H Uronic isomerase S101267_01431 ENOG4107KJX Transcriptional regulator S101267_01432 ENOG4105CTX dehydratase S101267_01433 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_01434 ENOG4105BZU Histidine kinase S101267_01436 ENOG4107TSN permease S101267_01440 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101267_01441 ENOG4105KWG Pfam:DUF1696 S101267_01442 ENOG4105K7W phage-related replication protein S101267_01443 ENOG410635T phage-like element pbsx protein S101267_01452 ENOG4108TFU terminase (Small subunit) S101267_01453 ENOG4105IG6 Phage terminase, large subunit S101267_01454 ENOG4108MDF Phage Portal Protein S101267_01458 ENOG41060SN S101267_01461 ENOG4105PQS phage protein S101267_01462 ENOG4105FR7 XkdM protein, phage-like element PBSX S101267_01463 ENOG4105MTC XkdN-like protein S101267_01465 ENOG4108FKH Transglycosylase SLT domain S101267_01465 ENOG4108FKH Transglycosylase SLT domain S101267_01465 ENOG4108FKH Transglycosylase SLT domain S101267_01466 ENOG4108WZM domain protein S101267_01467 ENOG4105X7F S101267_01469 ENOG4105MFU Protein of unknown function (DUF2634) S101267_01470 ENOG41066EA baseplate J family protein S101267_01471 ENOG410906S phage-like element pbsx protein xkdt S101267_01473 ENOG41068G1 S101267_01479 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S101267_01482 ENOG4105CJ3 phosphate transporter S101267_01483 ENOG4107GRR phosphate transport regulator S101267_01484 ENOG4107R7I amino acid S101267_01486 ENOG4105EDW glycosyl transferase, family 39 S101267_01487 ENOG4105CKK Glycosyl transferase, family 2 S101267_01489 ENOG4105C0H protease S101267_01491 ENOG4108ME1 Peptidase M55 D-aminopeptidase S101267_01492 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101267_01493 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101267_01494 ENOG4105C3U ABC transporter S101267_01496 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S101267_01497 ENOG4105DTQ mandelate racemase muconate lactonizing S101267_01498 ENOG4107SN7 NLP P60 protein S101267_01499 ENOG4108JQ7 (ABC) transporter S101267_01500 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) S101267_01501 ENOG4107TUM Amidinotransferase S101267_01502 ENOG4108S4H thioesterase Superfamily protein S101267_01503 ENOG4108428 Inherit from COG: -acetyltransferase S101267_01505 ENOG41080TC multidrug resistance protein S101267_01506 ENOG4105CIY formyltetrahydrofolate deformylase S101267_01507 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101267_01510 ENOG4105K56 Transcriptional regulator S101267_01511 ENOG4108ZHJ Organic hydroperoxide resistance protein S101267_01514 ENOG4107TVC Glycosyl transferase, family 2 S101267_01516 ENOG4105D8G Major Facilitator superfamily S101267_01517 ENOG4108Y4K DNA-binding transcriptional activator S101267_01518 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) S101267_01519 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101267_01521 ENOG4108W7F transporter, permease S101267_01522 ENOG4108JJB ABC transporter S101267_01523 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein S101267_01524 ENOG4105VRS hydrolase family 18 S101267_01526 ENOG4105CJW magnesium transporter S101267_01527 ENOG4105V75 Transcriptional regulator S101267_01532 ENOG4105DQE DNA ligase S101267_01533 ENOG4105FDF Could be involved in DNA repair (By similarity) S101267_01534 ENOG4105BZU Histidine kinase S101267_01535 ENOG4107T5V SNARE associated Golgi S101267_01536 ENOG4107TS3 membrane protein, TerC S101267_01537 ENOG4108WZW RNA polymerase sigma S101267_01539 ENOG410681C small acid-soluble spore protein S101267_01541 ENOG4105D0M Protease HtpX homolog S101267_01543 ENOG410900G Protein of unknown function (DUF421) S101267_01545 ENOG4108TGC Acyltransferase S101267_01546 ENOG4105BZU Histidine kinase S101267_01547 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101267_01549 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) S101267_01551 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101267_01553 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate S101267_01554 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) S101267_01555 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) S101267_01556 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) S101267_01558 ENOG4105BZU Histidine kinase S101267_01559 ENOG41090MY MarR family Transcriptional regulator S101267_01560 ENOG4105ER2 Ompa motb domain protein S101267_01561 ENOG4105E14 MotA TolQ exbB proton channel S101267_01563 ENOG4108K88 Membrane S101267_01566 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101267_01567 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase S101267_01568 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S101267_01569 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S101267_01573 ENOG4105F0V Cell wall hydrolase S101267_01576 ENOG4105C59 p-type ATPase S101267_01577 ENOG4105DC7 peptidase M24 S101267_01579 ENOG4105CID antiterminator S101267_01581 ENOG4105KRI phosphocarrier protein (HPr S101267_01582 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) S101267_01584 ENOG4105F6S Spore photoproduct lyase S101267_01585 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer S101267_01586 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S101267_01588 ENOG4105K4I Scp-like extracellular S101267_01590 ENOG4105BZU Histidine kinase S101267_01591 ENOG4105CHM Aminotransferase S101267_01593 ENOG4107R88 Chemotaxis protein (CheV) S101267_01594 ENOG4105UIN S101267_01596 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein S101267_01598 ENOG4105K6S Short-chain dehydrogenase reductase Sdr S101267_01600 ENOG4105EPM Diguanylate phosphodiesterase S101267_01601 ENOG4107IN1 Protein of unknown function (DUF1797) S101267_01602 ENOG4108XRC Protein of unknown function (DUF458) S101267_01608 ENOG4105NQC Flavodoxin S101267_01612 ENOG4105D8X mechanosensitive ion channel S101267_01614 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101267_01618 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) S101267_01619 ENOG4105D06 uba thif-type nad fad binding protein S101267_01620 ENOG4105CVM Molybdenum cofactor synthesis domain protein S101267_01621 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein S101267_01622 ENOG4108ZAF Molybdopterin S101267_01623 ENOG41067WU Molybdopterin converting factor (Subunit 1) S101267_01625 ENOG4107X8C Efflux transporter RND family MFP subunit S101267_01626 ENOG4105C19 ABC transporter S101267_01627 ENOG4107RBB ABC transporter, permease S101267_01628 ENOG4105E98 transcriptional regulator DeoR family S101267_01629 ENOG4105DE4 1-phosphofructokinase S101267_01630 ENOG4105DM4 PTS System S101267_01633 ENOG4105C5H ABC transporter S101267_01634 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) S101267_01635 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) S101267_01640 ENOG4105BZU Histidine kinase S101267_01642 ENOG4107ZYR domain protein S101267_01643 ENOG4105CPN adenine deaminase S101267_01644 ENOG4105CN5 Metallo-Beta-Lactamase S101267_01645 ENOG4106148 UPF0356 protein S101267_01646 ENOG4108X4Q Hydrolase S101267_01647 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101267_01651 ENOG4105CPP Dehydrogenase, E1 component S101267_01652 ENOG4105C7S Dehydrogenase S101267_01653 ENOG4107QN2 dihydrolipoyl dehydrogenase S101267_01657 ENOG4105CXN decarboxylase S101267_01658 ENOG4105WBI UPF0223 protein S101267_01661 ENOG4105ECY inositol monophosphatase S101267_01663 ENOG4105D4Y metalloprotease S101267_01668 ENOG4105CI3 gtp-binding protein typa S101267_01669 ENOG4105QA2 S101267_01672 ENOG4108IAB Phoh family S101267_01674 ENOG4105CSV Glutaminase S101267_01676 ENOG4105CNI cell division protein FtsW S101267_01677 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) S101267_01679 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101267_01681 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101267_01682 ENOG4105CCU oxidase (Subunit III) S101267_01683 ENOG41064X9 cytochrome C oxidase subunit IV S101267_01686 ENOG41080XQ Signal transduction protein with cbs domains S101267_01687 ENOG4106UY4 Inherit from COG: Scp-like extracellular S101267_01692 ENOG4106H78 methyltransferase S101267_01693 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) S101267_01694 ENOG4105H20 Sporulation integral membrane protein YlbJ S101267_01695 ENOG4105D78 K07001 NTE family protein S101267_01696 ENOG41063PX domain protein S101267_01697 ENOG4105CDE UPF0348 protein S101267_01698 ENOG4105KNH Nucleic acid-binding protein S101267_01699 ENOG41067VY 50S ribosomal protein L32 S101267_01704 ENOG4108V6E Cell division protein mraZ S101267_01705 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) S101267_01707 ENOG4105CJN penicillin-binding protein S101267_01708 ENOG4105CJN penicillin-binding protein S101267_01709 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) S101267_01710 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) S101267_01711 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) S101267_01712 ENOG4105CNI cell division protein FtsW S101267_01713 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) S101267_01714 ENOG4105D4A Cell wall formation (By similarity) S101267_01715 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) S101267_01716 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) S101267_01717 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) S101267_01719 ENOG4105FFI sigma-e processing peptidase spoiiga S101267_01720 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_01722 ENOG4105DKW ABC transporter S101267_01724 ENOG4105WR5 sporulation protein, YlmC YmxH family S101267_01725 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase S101267_01726 ENOG4105DFA alanine racemase domain protein S101267_01727 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) S101267_01728 ENOG41067XK integral membrane protein S101267_01729 ENOG4105DBK s4 domain protein S101267_01731 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) S101267_01733 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) S101267_01734 ENOG4105C34 Pseudouridine synthase S101267_01735 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) S101267_01737 ENOG4105CXT aspartate transcarbamylase S101267_01739 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101267_01740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain S101267_01741 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) S101267_01742 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) S101267_01743 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) S101267_01744 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) S101267_01748 ENOG4107RIQ Sulfate adenylate transferase S101267_01750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101267_01751 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein S101267_01752 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein S101267_01754 ENOG4105F23 Fibronectin-binding protein S101267_01756 ENOG4105DSJ YicC domain protein S101267_01757 ENOG4105KC4 UPF0296 protein S101267_01758 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S101267_01760 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase S101267_01761 ENOG4105C25 Primosomal protein n' S101267_01762 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101267_01763 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) S101267_01764 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B S101267_01765 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs S101267_01766 ENOG4108ZF3 Phosphatase S101267_01767 ENOG4105D9P serine threonine protein kinase S101267_01768 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) S101267_01769 ENOG4105DJV ribulose-phosphate 3-epimerase S101267_01770 ENOG4105FJ0 thiamine S101267_01771 ENOG4105VB9 50S ribosomal protein l28 S101267_01772 ENOG4108ZAA Alkaline-shock protein S101267_01773 ENOG4105DP4 dak2 domain fusion protein ylov S101267_01775 ENOG4105EJQ L-serine dehydratase S101267_01776 ENOG4105CB5 ATP-dependent DNA helicase recG S101267_01777 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) S101267_01778 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) S101267_01779 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101267_01780 ENOG4105CHR reductase S101267_01781 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) S101267_01782 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) S101267_01783 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) S101267_01784 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) S101267_01785 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) S101267_01787 ENOG4105K5M 30s ribosomal protein S16 S101267_01788 ENOG4108BW8 UPF0109 protein S101267_01791 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) S101267_01792 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) S101267_01793 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) S101267_01794 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101267_01796 ENOG4105VM1 flagellar S101267_01797 ENOG4105CMV Succinyl-CoA synthetase subunit beta S101267_01798 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha S101267_01799 ENOG4105C79 DNA protecting protein DprA S101267_01800 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) S101267_01801 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) S101267_01802 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101267_01803 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) S101267_01804 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) S101267_01806 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) S101267_01807 ENOG4108ZC9 flagellar basal-body rod protein flgc S101267_01808 ENOG4105VQ0 flagellar hook-basal body complex protein fliE S101267_01809 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) S101267_01810 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101267_01813 ENOG4106YF4 Flagellar biosynthesis chaperone S101267_01815 ENOG410696Y Flagellar hook-length control protein S101267_01816 ENOG410822I Flagellar hook capping protein S101267_01817 ENOG4108JQA flagellar S101267_01819 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101267_01820 ENOG4105DD5 Flagellar motor switch protein S101267_01821 ENOG4107YTP response regulator receiver protein S101267_01823 ENOG4105CN7 Flagellar biosynthetic protein FliP S101267_01824 ENOG4105VS8 Flagellar biosynthetic protein fliq S101267_01825 ENOG4105D19 Role in flagellar biosynthesis (By similarity) S101267_01826 ENOG4105D00 flagellar biosynthetic protein flhB S101267_01827 ENOG4105D7B Flagellar biosynthesis protein flha S101267_01828 ENOG4105FZW flagellar biosynthesis regulator FlhF S101267_01830 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) S101267_01831 ENOG4105CBS Chea signal transduction histidine kinase S101267_01832 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis S101267_01834 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) S101267_01835 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_01837 ENOG4105CE9 30S ribosomal protein S2 S101267_01839 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) S101267_01840 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) S101267_01841 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) S101267_01842 ENOG4105KNE Phosphatidate cytidylyltransferase S101267_01844 ENOG4105DZP Membrane-associated zinc metalloprotease S101267_01845 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) S101267_01846 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) S101267_01847 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) S101267_01848 ENOG4105CHV Transcription elongation factor NusA S101267_01849 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination S101267_01850 ENOG4105VHM ribosomal protein S101267_01851 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S101267_01852 ENOG4105W7A Protein of unknown function (DUF503) S101267_01853 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) S101267_01854 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) S101267_01855 ENOG4105DTN riboflavin biosynthesis protein ribF S101267_01856 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) S101267_01857 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) S101267_01859 ENOG4105C1V Peptidase, M16 S101267_01861 ENOG4105E35 Dipicolinate synthase subunit A S101267_01862 ENOG4108S0H Dipicolinic acid synthetase, b subunit S101267_01863 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) S101267_01865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S101267_01867 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit S101267_01869 ENOG4105CNU cell division protein FtsK S101267_01870 ENOG4105FDP GntR family transcriptional regulator S101267_01873 ENOG4105EYF MMPL domain protein S101267_01876 ENOG4108RKS Short-chain dehydrogenase reductase Sdr S101267_01877 ENOG4105XZV Protein of unknown function (DUF3243) S101267_01880 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S101267_01881 ENOG4105CEV competence damage-inducible protein S101267_01882 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) S101267_01883 ENOG4108A04 Beta-lactamase S101267_01885 ENOG4105D48 metallophosphoesterase S101267_01886 ENOG4105MCT stage V sporulation protein S S101267_01887 ENOG4105CPQ Dehydrogenase S101267_01888 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101267_01889 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101267_01893 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S101267_01894 ENOG4108151 Beta-lactamase domain protein S101267_01895 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101267_01896 ENOG4108JA1 polyketide synthase S101267_01897 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101267_01898 ENOG41062T2 Acyl carrier protein S101267_01899 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase S101267_01900 ENOG4108MGH Enoyl-CoA hydratase S101267_01901 ENOG4108KQ6 Enoyl-CoA hydratase S101267_01902 ENOG4105C0W non-ribosomal peptide synthetase S101267_01903 ENOG4107SQU synthase S101267_01905 ENOG4105C0W non-ribosomal peptide synthetase S101267_01907 ENOG4106A3M Cytochrome p-450 S101267_01908 ENOG4105WFK nuclease S101267_01909 ENOG4105XPP Protein of unknown function (DUF1275) S101267_01911 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101267_01913 ENOG4105K7W phage-related replication protein S101267_01914 ENOG4108X3M OsmC Ohr family protein S101267_01919 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) S101267_01924 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101267_01925 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101267_01926 ENOG4105U6W MutT NUDIX family protein S101267_01927 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_01928 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_01929 ENOG4106F1P AAA ATPase, central domain protein S101267_01930 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) S101267_01931 ENOG4105CXI aluminum resistance protein S101267_01932 ENOG4105KV4 Transcriptional regulator S101267_01933 ENOG4105C5F glutamine synthetase S101267_01934 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101267_01938 ENOG4108ZUE Phage regulatory protein rha S101267_01947 ENOG4105C2M dna polymerase I S101267_01969 ENOG4108FKH Transglycosylase SLT domain S101267_01971 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101267_01973 ENOG41068G1 S101267_01977 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101267_01983 ENOG4107T94 Endo-14-beta-xylanase S101267_01985 ENOG4105CT4 transporter S101267_01986 ENOG4105DSG hydrolase family 43 S101267_01989 ENOG4105C93 Xylose Isomerase S101267_01990 ENOG4105CMG Carbohydrate kinase S101267_01992 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S101267_01996 ENOG410780I phosphoprotein phosphatase activity S101267_02004 ENOG41090VF Stage v sporulation protein ac S101267_02005 ENOG4105CZ3 stage V sporulation protein ad S101267_02008 ENOG4108QY0 Membrane S101267_02010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101267_02011 ENOG4105H67 Protein of unknown function (DUF421) S101267_02014 ENOG4105DQ4 alcohol dehydrogenase S101267_02019 ENOG4105EPI acetyltransferase, (GNAT) family S101267_02026 ENOG4108M1A Chitin-binding protein S101267_02031 ENOG4105YB8 TM2 domain containing protein S101267_02032 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101267_02034 ENOG4105K7W phage-related replication protein S101267_02039 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S101267_02041 ENOG4108SVB resolvase S101267_02042 ENOG4105VPS UPF0291 protein S101267_02043 ENOG4105CV1 Transketolase (EC 2.2.1.1) S101267_02045 ENOG4105VXM UPF0154 protein S101267_02047 ENOG4107QIV Cytochrome c biogenesis protein S101267_02054 ENOG4108I0Z Aconitate hydratase S101267_02055 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101267_02057 ENOG41067CD Small, acid-soluble spore protein Tlp S101267_02059 ENOG4105MI2 S101267_02060 ENOG4105W8X HesB YadR YfhF-family protein S101267_02061 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) S101267_02062 ENOG4105K4P CoA-binding domain protein S101267_02063 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101267_02070 ENOG4105FVX S101267_02073 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101267_02075 ENOG4107SYN Glycosyl hydrolases family 43 S101267_02080 ENOG4105DTD Dehydrogenase S101267_02081 ENOG4108IIH CoA-transferase subunit B S101267_02082 ENOG4105D6N CoA-transferase, subunit a S101267_02083 ENOG4106A3M Cytochrome p-450 S101267_02084 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) S101267_02085 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) S101267_02086 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101267_02087 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101267_02090 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101267_02091 ENOG4107T5V SNARE associated Golgi S101267_02092 ENOG4107QX3 carboxylase S101267_02093 ENOG4105E39 Enoyl-CoA hydratase S101267_02094 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase S101267_02095 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit S101267_02096 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101267_02097 ENOG4105CEY Amp-dependent synthetase and ligase S101267_02098 ENOG4105CEY Amp-dependent synthetase and ligase S101267_02099 ENOG4105C1G acyl-Coa dehydrogenase S101267_02100 ENOG4105F32 YngK protein S101267_02101 ENOG4106U2H Protein of unknown function (DUF1360) S101267_02103 ENOG4105CEY Amp-dependent synthetase and ligase S101267_02104 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family S101267_02105 ENOG4108N2V aldose 1-epimerase S101267_02106 ENOG4107QJQ Mate efflux family protein S101267_02111 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101267_02112 ENOG4108RWP Major Facilitator Superfamily protein S101267_02113 ENOG4105WAB arsR family transcriptional regulator S101267_02114 ENOG4105C22 threonyL-tRNA synthetase S101267_02115 ENOG4105BZ8 glutamate synthase S101267_02116 ENOG4105CBC glutamate synthase S101267_02117 ENOG4105C5Q Transcriptional regulator S101267_02118 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101267_02123 ENOG4108UB7 S101267_02124 ENOG4105H67 Protein of unknown function (DUF421) S101267_02125 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101267_02127 ENOG4108QY0 Membrane S101267_02130 ENOG4105CZ3 stage V sporulation protein ad S101267_02131 ENOG41090VF Stage v sporulation protein ac S101267_02138 ENOG4105IE8 Alpha-ketoglutarate permease S101267_02139 ENOG4107U6E carbohydrate kinase FGGY S101267_02140 ENOG4108M3J Dehydrogenase S101267_02141 ENOG4108M3J Dehydrogenase S101267_02142 ENOG4108J2R molybdopterin oxidoreductase S101267_02149 ENOG4108Z7R Chaperone CsaA S101267_02150 ENOG4105FTV AraC Family Transcriptional Regulator S101267_02152 ENOG4108W8B Beta-lactamase domain protein S101267_02154 ENOG4105KTU Transcriptional regulator, arsr family S101267_02156 ENOG4108SJC Membrane S101267_02161 ENOG41069ER domain protein S101267_02162 ENOG4105C9U ATP-dependent DNA helicase RecQ S101267_02164 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S101267_02165 ENOG4105SCY DNAK suppressor S101267_02174 ENOG4105C26 Dehydrogenase S101267_02175 ENOG4105EWU Squalene--hopene cyclase S101267_02176 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101267_02177 ENOG4105C8J )-transporter S101267_02178 ENOG4105C09 Bile acid S101267_02180 ENOG4105C7S Dehydrogenase S101267_02181 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 S101267_02182 ENOG4107T89 von Willebrand factor, type A S101267_02183 ENOG4105GMT ATPase associated with various cellular activities aaa_5 S101267_02185 ENOG4105K4H Nlp p60 protein S101267_02186 ENOG41087PP glycosyltransferase MGT family S101267_02189 ENOG4107QMU Mate efflux family protein S101267_02190 ENOG4106SCS STAS domain S101267_02194 ENOG4105FR1 rard protein S101267_02197 ENOG41090U3 tautomerase S101267_02200 ENOG4105FBA Phospholipase Carboxylesterase S101267_02203 ENOG4105E1V na solute symporter S101267_02205 ENOG4105CS2 ec 3.2.1.21 S101267_02206 ENOG4108S3Y transcriptional regulator S101267_02210 ENOG4108VXD carboxy-peptidase S101267_02211 ENOG4105D3A purine nucleoside phosphorylase DeoD-type S101267_02213 ENOG4106Z5R S101267_02214 ENOG410841Q phosphoesterase PA-phosphatase related protein S101267_02218 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily S101267_02221 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein S101267_02222 ENOG4108TSC N-acetyltransferase S101267_02223 ENOG4107S4Y M20 DapE family protein YgeY S101267_02226 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101267_02228 ENOG4105FTQ Dna gyrase S101267_02236 ENOG4105C5E polysaccharide biosynthesis protein S101267_02239 ENOG4105DMF Dehydrogenase S101267_02244 ENOG4105E0X reductase S101267_02245 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) S101267_02247 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S101267_02248 ENOG41090WU lipolytic protein G-D-S-L family S101267_02249 ENOG4108KF3 Electron transport protein SCO1 SenC S101267_02251 ENOG4105C7B Threonine dehydratase S101267_02253 ENOG4108UT2 hemolysin iii S101267_02255 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S101267_02256 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S101267_02258 ENOG4107YX5 Pfam:DUF548 S101267_02259 ENOG4108Y6J UPF0403 protein S101267_02260 ENOG4105C01 Dihydroxy-acid dehydratase S101267_02263 ENOG4108V06 Glutathione peroxidase S101267_02265 ENOG4105CVG Homoserine O-transsuccinylase S101267_02273 ENOG41081VK Ribonuclease S101267_02278 ENOG410890F Dynamin family S101267_02280 ENOG41065KQ synthase S101267_02284 ENOG4105C2W permease S101267_02285 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) S101267_02286 ENOG4105CTD carboxy-peptidase S101267_02287 ENOG4105DVT helicase S101267_02291 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) S101267_02292 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) S101267_02293 ENOG4108UKS UPF0398 protein S101267_02296 ENOG4107X2U Inherit from COG: Exonuclease-like protein S101267_02297 ENOG4108I5C dEAD DEAH box helicase S101267_02306 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) S101267_02307 ENOG4105BZ4 penicillin-binding protein S101267_02309 ENOG4105CSM endonuclease III S101267_02311 ENOG4105C5S asparaginyl-tRNA synthetase S101267_02312 ENOG4105CHM Aminotransferase S101267_02314 ENOG4105YAC S101267_02315 ENOG4105DVT helicase S101267_02316 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) S101267_02318 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) S101267_02320 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate S101267_02321 ENOG4105CPK Glycosyl transferase (Group 1 S101267_02322 ENOG4105FJR Lmbe family S101267_02323 ENOG4108Z5K methylglyoxal synthase S101267_02324 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) S101267_02325 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase S101267_02326 ENOG4108JYZ YitT family S101267_02327 ENOG4105F0F Oxalate decarboxylase S101267_02331 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) S101267_02335 ENOG41068YB TPR repeat-containing protein S101267_02336 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase S101267_02338 ENOG4105CIH Imidazole acetol-phosphate transaminase S101267_02340 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S101267_02341 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase S101267_02342 ENOG4105DK0 Indole-3-glycerol phosphate synthase S101267_02344 ENOG4105CRQ synthase (Component I) S101267_02345 ENOG4105KHN chorismate mutase S101267_02347 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase S101267_02348 ENOG4105BZU Histidine kinase S101267_02349 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) S101267_02350 ENOG4105EAH synthase S101267_02351 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S101267_02352 ENOG4105XXQ heptaprenyl diphosphate synthase component I S101267_02353 ENOG4105WP2 Tryptophan RNA-binding attenuator protein S101267_02354 ENOG4105EUJ GTP cyclohydrolase i S101267_02355 ENOG4105K70 DNA-binding protein S101267_02356 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) S101267_02360 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase S101267_02361 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) S101267_02365 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) S101267_02366 ENOG4105CAT Cytidine monophosphate kinase S101267_02369 ENOG4105MSI germination protein ypeb S101267_02371 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) S101267_02372 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase S101267_02375 ENOG4107RGJ metallophosphoesterase S101267_02378 ENOG4105I7S Abortive infection protein S101267_02379 ENOG4105C9U ATP-dependent DNA helicase RecQ S101267_02380 ENOG4105T7X S101267_02382 ENOG4108SAX Membrane S101267_02383 ENOG4108JQ1 Dehydrogenase S101267_02386 ENOG4105BZU Histidine kinase S101267_02387 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_02388 ENOG4105CRE cytochrome C S101267_02389 ENOG4107TWT Cytochrome c biogenesis protein S101267_02391 ENOG4105FE9 pseudouridine synthase S101267_02393 ENOG4108JIC nucleoside recognition domain protein S101267_02394 ENOG4105DZ1 carboxypeptidase S101267_02396 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) S101267_02397 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) S101267_02401 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) S101267_02402 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) S101267_02403 ENOG4108R6K riboflavin synthase, subunit alpha S101267_02408 ENOG4107ZE5 PPIases accelerate the folding of proteins S101267_02409 ENOG4105PTM secreted protein S101267_02410 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) S101267_02412 ENOG4105G6R Stage v sporulation protein ae S101267_02414 ENOG4105CZ3 stage V sporulation protein ad S101267_02415 ENOG41090VF Stage v sporulation protein ac S101267_02418 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_02419 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S101267_02420 ENOG41082AN stage II sporulation protein S101267_02421 ENOG4105DZ1 carboxypeptidase S101267_02422 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) S101267_02423 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S101267_02424 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101267_02426 ENOG4105I3K Ferric uptake regulator, Fur family S101267_02427 ENOG4105MZ9 stage II sporulation protein m S101267_02431 ENOG4105DFD Na H antiporter S101267_02432 ENOG4108IJ0 Aspartate ammonia-lyase S101267_02433 ENOG4105HDK L-asparaginase S101267_02434 ENOG4108IMY Transcriptional regulator S101267_02436 ENOG4108YZ4 nudix hydrolase S101267_02438 ENOG4105CPC Aldo Keto reductase S101267_02442 ENOG4106HZJ S101267_02443 ENOG4105RHY Pfam:UPF0157 S101267_02444 ENOG4105KAC Antibiotic biosynthesis monooxygenase S101267_02445 ENOG4108XET gCN5-related N-acetyltransferase S101267_02446 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101267_02449 ENOG4105C02 permease S101267_02451 ENOG4105CS9 pantothenic acid kinase S101267_02453 ENOG4108IXY short-chain dehydrogenase reductase S101267_02454 ENOG41069FQ Metallo-beta-lactamase superfamily S101267_02455 ENOG4105II7 pyrroline-5-carboxylate reductase S101267_02456 ENOG4108K70 Transcriptional regulator S101267_02458 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101267_02459 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101267_02461 ENOG410861F 50S ribosomal protein L33 S101267_02462 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) S101267_02463 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase S101267_02464 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S101267_02465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101267_02467 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) S101267_02468 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101267_02469 ENOG4108HNZ carboxyl transferase S101267_02470 ENOG4108ZVT methylmalonyl-coA epimerase S101267_02472 ENOG4108VZI ErfK ybiS ycfS ynhG family protein S101267_02473 ENOG4108QEG Membrane S101267_02474 ENOG4105CDA abc transporter atp-binding protein S101267_02475 ENOG4105E5Q amino acid AbC transporter S101267_02476 ENOG4108HW3 (ABC) transporter S101267_02477 ENOG4108Y6J UPF0403 protein S101267_02478 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) S101267_02479 ENOG4105C7S Dehydrogenase S101267_02480 ENOG4105CPP Dehydrogenase, E1 component S101267_02483 ENOG4105CKM Branched-chain carboxylic acid kinase S101267_02484 ENOG4107RDP Dehydrogenase S101267_02486 ENOG4108JUB Transcriptional regulator S101267_02487 ENOG4106CCJ Protein of unknown function (DUF2627) S101267_02488 ENOG4105CR4 methylisocitrate lyase S101267_02489 ENOG4105DXD 2-methylcitrate dehydratase S101267_02491 ENOG4105C1G acyl-Coa dehydrogenase S101267_02492 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S101267_02493 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S101267_02495 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101267_02496 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_02501 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101267_02504 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101267_02506 ENOG4107QQR Sporulation S101267_02507 ENOG4105S1Z Stage IV sporulation protein B S101267_02508 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) S101267_02509 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S101267_02510 ENOG4105DX0 Hemolysin A S101267_02511 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) S101267_02512 ENOG4105CTB Polyprenyl synthetase S101267_02513 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101267_02514 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101267_02515 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) S101267_02516 ENOG4105M7K Involved in the transcription termination process (By similarity) S101267_02517 ENOG4108ZSR alkaline shock protein S101267_02518 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101267_02522 ENOG410644B Stage III sporulation protein af S101267_02524 ENOG4105KQ4 Stage iii sporulation protein ad S101267_02525 ENOG4108CQH stage III sporulation protein AC S101267_02526 ENOG4105KR5 Stage iii sporulation protein S101267_02527 ENOG4105CD2 stage iii sporulation protein aa S101267_02529 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) S101267_02530 ENOG4105DC7 peptidase M24 S101267_02532 ENOG4105CBJ Metal-dependent enzyme S101267_02536 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) S101267_02537 ENOG4105WZW rhodanese family S101267_02538 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S101267_02540 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) S101267_02541 ENOG4105C0D helicase S101267_02544 ENOG4108IMY Transcriptional regulator S101267_02546 ENOG4105VFR signal peptidase S101267_02558 ENOG4105C37 (CBS) domain S101267_02563 ENOG4105C5X domain protein S101267_02572 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase S101267_02573 ENOG4105WDJ 50S ribosomal protein L33 S101267_02575 ENOG41068DG YceG-like family S101267_02576 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101267_02577 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101267_02578 ENOG4105E2Z phosphate ABC transporter (Permease S101267_02579 ENOG4105C8U phosphate abc transporter S101267_02580 ENOG4105CVA phosphate S101267_02581 ENOG4107RF6 penicillin-binding protein S101267_02583 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101267_02584 ENOG4105SXS Protein of unknown function (DUF456) S101267_02587 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) S101267_02588 ENOG41063Y9 S101267_02589 ENOG4108U5J '-nucleotidase S101267_02590 ENOG4105N80 Ferric uptake regulator, Fur family S101267_02591 ENOG4108JYZ YitT family S101267_02592 ENOG41069ZM Protein of unknown function (DUF2624) S101267_02593 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) S101267_02596 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) S101267_02597 ENOG4105EGD dinuclear metal center protein, YbgI family S101267_02600 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_02601 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S101267_02602 ENOG4108UPT UPF0178 protein S101267_02603 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) S101267_02605 ENOG4105C38 Glycyl-tRNA synthetase beta subunit S101267_02606 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit S101267_02607 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) S101267_02609 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) S101267_02610 ENOG4105KG3 cytidine deaminase S101267_02611 ENOG4107YR5 Diacylglycerol kinase S101267_02612 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) S101267_02613 ENOG4105CTJ Metal Dependent Phosphohydrolase S101267_02614 ENOG4105C9A Phoh family S101267_02615 ENOG4105EI1 sporulation protein yqfd S101267_02616 ENOG41068P3 sporulation protein YqfC S101267_02618 ENOG4105DI5 UPF0365 protein S101267_02619 ENOG4105F7J membrane-bound serine protease S101267_02620 ENOG4105KTH gatB Yqey S101267_02623 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101267_02624 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) S101267_02625 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) S101267_02626 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) S101267_02627 ENOG4105CFG Acts as a chaperone (By similarity) S101267_02628 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ S101267_02629 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) S101267_02630 ENOG4105CSA Coproporphyrinogen iii oxidase S101267_02631 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) S101267_02633 ENOG4108ZRV stage ii sporulation protein p S101267_02634 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) S101267_02635 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) S101267_02636 ENOG4105TQK DNA polymerase iii, delta' subunit S101267_02637 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S101267_02638 ENOG4108UK2 deaminase S101267_02639 ENOG4105KQC Competence protein S101267_02641 ENOG4108D32 Methyltransferase S101267_02643 ENOG4108WF2 Metal Dependent Phosphohydrolase S101267_02644 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S101267_02645 ENOG410812S Rna-binding protein S101267_02646 ENOG4105E2X shikimate dehydrogenase S101267_02647 ENOG4105CQW ribosome biogenesis GTPase YqeH S101267_02648 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S101267_02652 ENOG41080BT SNARE associated Golgi S101267_02656 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_02657 ENOG4107Y5K Resolvase S101267_02659 ENOG4105CHR reductase S101267_02663 ENOG4105DDQ anthranilate synthase S101267_02668 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S101267_02671 ENOG4105D29 Helix-turn-helix type 11 domain protein S101267_02672 ENOG4108V4B ThiJ pfpI S101267_02680 ENOG4105MFU Protein of unknown function (DUF2634) S101267_02688 ENOG41086D8 Transcriptional regulator S101267_02690 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) S101267_02692 ENOG4108J8C transporter major facilitator family protein S101267_02693 ENOG4108U7W acetyltransferase S101267_02696 ENOG4105DQF Hydrolase S101267_02697 ENOG4108HCJ Hydrolase S101267_02698 ENOG4108HCJ Hydrolase S101267_02700 ENOG4105DG6 mannose-6-phosphate isomerase S101267_02701 ENOG4105DM4 PTS System S101267_02704 ENOG4108Z66 YbaK ebsC protein S101267_02705 ENOG4107RSM transcriptional regulator S101267_02706 ENOG4105D94 Major Facilitator Superfamily S101267_02707 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101267_02708 ENOG41082JN Transcriptional regulator S101267_02711 ENOG4105TMB Formate nitrite transporter S101267_02712 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S101267_02713 ENOG4108JB9 formate dehydrogenase S101267_02716 ENOG4105C28 cystathionine S101267_02722 ENOG4107XRG penicillin-binding protein S101267_02723 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) S101267_02727 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101267_02731 ENOG41068G1 S101267_02733 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101267_02735 ENOG4108FKH Transglycosylase SLT domain S101267_02750 ENOG4105CNU cell division protein FtsK S101267_02752 ENOG410682Q Phage transcriptional regulator, ArpU S101267_02779 ENOG4105CFP Peptidase U32 S101267_02780 ENOG4105XYU peptidase (U32 family) S101267_02781 ENOG4108VQJ O-methyltransferase S101267_02782 ENOG4105HHA aminodeoxychorismate lyase S101267_02784 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) S101267_02785 ENOG4105VBH UPF0297 protein S101267_02786 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) S101267_02787 ENOG4105C02 permease S101267_02788 ENOG4105CDA abc transporter atp-binding protein S101267_02789 ENOG4105CT1 (ABC) transporter S101267_02790 ENOG4105EAD ABC transporter S101267_02791 ENOG4105DRP amino acid AbC transporter S101267_02793 ENOG41060CR S101267_02795 ENOG4105C7H Helicase, RecD TraA family S101267_02797 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S101267_02798 ENOG4105C3J Cysteine desulfurase S101267_02800 ENOG4105D1H recombination factor protein RarA S101267_02801 ENOG4105CUZ uba thif-type nad fad binding protein S101267_02802 ENOG4105C9M aspartyl-trna synthetase S101267_02803 ENOG4105CUT histidyl-tRNA synthetase S101267_02806 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_02807 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) S101267_02808 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) S101267_02810 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) S101267_02811 ENOG41067VP Protein of unknown function (DUF1049) S101267_02812 ENOG4105NCW Trka-c domain protein S101267_02813 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) S101267_02815 ENOG4105CKP Polysaccharide Biosynthesis Protein S101267_02816 ENOG4108QG2 Membrane S101267_02817 ENOG4105NAP S101267_02818 ENOG4105VIE preprotein translocase, subunit YajC S101267_02819 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) S101267_02820 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) S101267_02821 ENOG41061AI Protein of unknown function (DUF2905) S101267_02822 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) S101267_02823 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) S101267_02827 ENOG4106678 morphogenetic protein associated with SpoVID S101267_02828 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S101267_02829 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase S101267_02830 ENOG4108IYU L-aspartate oxidase S101267_02833 ENOG4105CQC Prephenate dehydratase S101267_02835 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control S101267_02837 ENOG4105K46 50S ribosomal protein l27 S101267_02838 ENOG4105X36 (ribosomal) protein S101267_02839 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) S101267_02842 ENOG4107QMS site-determining protein S101267_02843 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) S101267_02844 ENOG4105YHC Rod shape-determining protein MreD S101267_02845 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) S101267_02846 ENOG4105DFF Rod shape-determining protein mreb S101267_02847 ENOG4105W5Q DNA repair protein (RadC S101267_02848 ENOG4108Z03 MAF-like protein S101267_02850 ENOG4106A3R peptidase S101267_02851 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase S101267_02852 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) S101267_02854 ENOG4106AR7 Spore coat protein S101267_02855 ENOG41068KH stage VI sporulation protein D S101267_02856 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S101267_02857 ENOG4105D52 delta-aminolevulinic acid dehydratase S101267_02859 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) S101267_02861 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) S101267_02863 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) S101267_02864 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) S101267_02865 ENOG4108IUQ atp-dependent protease S101267_02866 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) S101267_02867 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation S101267_02869 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101267_02870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101267_02871 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101267_02873 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase S101267_02874 ENOG4108ZP8 Acetolactate synthase small subunit S101267_02875 ENOG4105C7K acetolactate synthase S101267_02880 ENOG4105M59 Phosphodiesterase, mj0936 family S101267_02881 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) S101267_02882 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) S101267_02883 ENOG4108XJQ germination protein S101267_02884 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S101267_02885 ENOG41067TZ transcriptional regulator, MarR family S101267_02886 ENOG4105PFC Transcriptional regulator S101267_02888 ENOG4105E33 succinate dehydrogenase S101267_02890 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit S101267_02892 ENOG4105CFH Aspartokinase S101267_02893 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) S101267_02894 ENOG4105K63 Thioredoxin S101267_02895 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S101267_02896 ENOG4105C10 Electron transfer flavoprotein S101267_02897 ENOG4105BZJ Electron transfer flavoprotein S101267_02898 ENOG41060WC Enoyl-CoA hydratase S101267_02899 ENOG4107Z3H Transcriptional regulator, TetR family S101267_02900 ENOG4105CEY Amp-dependent synthetase and ligase S101267_02901 ENOG4108YV3 Protein of unknown function (DUF2711) S101267_02903 ENOG4105C98 muts2 protein S101267_02904 ENOG4105DCG PHP domain protein S101267_02907 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101267_02908 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) S101267_02909 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) S101267_02910 ENOG4108RWN rrna methyltransferase S101267_02911 ENOG41067MF small acid-soluble spore protein S101267_02913 ENOG4105CQB FAD linked oxidase domain protein S101267_02914 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101267_02916 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) S101267_02917 ENOG4105DRS transport system, permease S101267_02920 ENOG4108MDK Dehydrogenase S101267_02922 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase S101267_02923 ENOG4105EF1 ribulokinase S101267_02925 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S101267_02926 ENOG4105CN9 Peptidase m42 family protein S101267_02928 ENOG410696E Membrane S101267_02929 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) S101267_02930 ENOG4105VJV 50s ribosomal protein L35 S101267_02931 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) S101267_02932 ENOG41067MG lrgb family S101267_02934 ENOG4105DY9 regulatoR S101267_02935 ENOG4108HRK Histidine kinase S101267_02936 ENOG4105U0R haloacid dehalogenase-like hydrolase S101267_02937 ENOG4105C22 threonyL-tRNA synthetase S101267_02938 ENOG4108TDW sporulation protein YtxC S101267_02943 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) S101267_02944 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101267_02945 ENOG4105KVH Transcriptional regulator S101267_02946 ENOG4105F27 Major Facilitator S101267_02947 ENOG4105CV8 reductase S101267_02948 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) S101267_02950 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) S101267_02951 ENOG4105C2M dna polymerase I S101267_02952 ENOG4105BZU Histidine kinase S101267_02953 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101267_02955 ENOG4108HMX isocitrate dehydrogenase (NADP) S101267_02956 ENOG4105BZN citrate synthase S101267_02958 ENOG4108REF Sporulation integral membrane protein ytvi S101267_02959 ENOG4105FS0 cytoplasmic membrane protein S101267_02960 ENOG4105CA9 Pyruvate kinase S101267_02961 ENOG4105CTQ phosphohexokinase S101267_02962 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) S101267_02963 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) S101267_02964 ENOG4105C6K Malic enzyme S101267_02965 ENOG4105C0B DNA polymerase III (alpha subunit) S101267_02966 ENOG4105VV2 S101267_02968 ENOG4106EVM S101267_02969 ENOG4105SFS phosphoesterase RecJ domain protein S101267_02972 ENOG4105E8R UPF0173 metal-dependent hydrolase S101267_02975 ENOG4105CH7 arginosuccinase S101267_02976 ENOG4105CDH Citrulline--aspartate ligase S101267_02977 ENOG4105EPU Molybdenum cofactor synthesis domain protein S101267_02978 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) S101267_02980 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) S101267_02981 ENOG4105KBJ sporulation protein ytfj S101267_02983 ENOG4105VK3 rdd domain containing protein S101267_02984 ENOG4105D07 Signal peptide peptidase, SppA S101267_02985 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S101267_02986 ENOG4105EFZ amidohydrolase S101267_02987 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S101267_02989 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) S101267_02994 ENOG4105U5Y Transcriptional regulator S101267_02996 ENOG4105BZU Histidine kinase S101267_02997 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) S101267_02998 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S101267_03001 ENOG4108Z0Z intracellular protease Pfpi family S101267_03005 ENOG4108NGU Transcriptional regulator S101267_03006 ENOG4108UMN azlc family S101267_03008 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101267_03010 ENOG4105F1V Acetoin utilization protein S101267_03011 ENOG4105W87 Cbs domain S101267_03012 ENOG4105DGU Histone deacetylase S101267_03013 ENOG4105ER2 Ompa motb domain protein S101267_03014 ENOG4107R0U MotA TolQ exbB proton channel S101267_03015 ENOG4105ETE Transcriptional regulator (LacI family S101267_03016 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase S101267_03020 ENOG4105DFU Cell wall formation (By similarity) S101267_03022 ENOG4108VDD TRNA binding domain protein S101267_03025 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ S101267_03028 ENOG4105C6K Malic enzyme S101267_03029 ENOG4105C8F Beta-lactamase domain protein S101267_03030 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) S101267_03032 ENOG4108V15 phosphotransferase enzyme family S101267_03035 ENOG4107F58 2'-5' rna ligase S101267_03036 ENOG4105C6T cysteine synthase S101267_03037 ENOG4107QSE Dipeptidase S101267_03038 ENOG4105C7N Xanthine uracil vitamin C permease S101267_03041 ENOG4105YW5 deoR family transcriptional regulator S101267_03044 ENOG4105CBX hi0933 family S101267_03045 ENOG4105C94 Transporter S101267_03049 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component S101267_03050 ENOG4105I1K ABC transporter S101267_03053 ENOG41085GJ domain protein S101267_03054 ENOG4105C8T Leucyl-tRNA synthetase S101267_03056 ENOG4105BZU Histidine kinase S101267_03057 ENOG410605W Major Facilitator S101267_03060 ENOG4105C19 ABC transporter S101267_03061 ENOG4105EWM Histidine kinase S101267_03063 ENOG4107R34 abc transporter permease protein S101267_03064 ENOG4105C19 ABC transporter S101267_03068 ENOG4105DVE abc transporter atp-binding protein S101267_03069 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S101267_03072 ENOG4105N5T Radical SAM Protein S101267_03076 ENOG4105E8V Alpha Beta Hydrolase Fold protein S101267_03077 ENOG4108Z0R Transferase S101267_03078 ENOG4105C85 amino acid S101267_03079 ENOG4105CAQ asparagine synthetase S101267_03080 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP S101267_03081 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase S101267_03084 ENOG4105D2X ABC transporter substrate-binding protein S101267_03086 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component S101267_03089 ENOG4108RMU ferritin dps family protein S101267_03092 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) S101267_03093 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) S101267_03094 ENOG4108V2W Carbonate dehydratase S101267_03095 ENOG4105NRA 50s ribosomal protein l31 type b S101267_03099 ENOG4105DTQ mandelate racemase muconate lactonizing S101267_03100 ENOG4105CEY Amp-dependent synthetase and ligase S101267_03101 ENOG4108IPT Naphthoate synthase S101267_03102 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) S101267_03103 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) S101267_03104 ENOG4105E4F Isochorismate synthase S101267_03131 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S101267_03132 ENOG4105DZ6 Band 7 protein S101267_03134 ENOG4106DF1 S101267_03135 ENOG4108VNY MOSC domain protein S101267_03136 ENOG4108JB8 alcohol dehydrogenase S101267_03137 ENOG4105C26 Dehydrogenase S101267_03138 ENOG4105TRT Transcriptional regulator S101267_03141 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101267_03142 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S101267_03154 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101267_03158 ENOG41068G1 S101267_03162 ENOG4108FKH Transglycosylase SLT domain S101267_03171 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101267_03183 ENOG4107QRS glycosyltransferase group 2 family protein S101267_03185 ENOG4105K7W phage-related replication protein S101267_03203 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) S101267_03205 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101267_03207 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101267_03209 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101267_03211 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101267_03212 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101267_03216 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) S101267_03220 ENOG4105C2M dna polymerase I S101267_03245 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101267_03247 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S101267_03249 ENOG4105EE0 oxidoreductase S101267_03250 ENOG4108Z0Z intracellular protease Pfpi family S101267_03251 ENOG4105C8Q Methyl-accepting chemotaxis S101267_03252 ENOG4105C8Q Methyl-accepting chemotaxis S101267_03253 ENOG4105C8Q Methyl-accepting chemotaxis S101267_03254 ENOG4105C8Q Methyl-accepting chemotaxis S101267_03257 ENOG4105EA8 2-Nitropropane dioxygenase S101267_03259 ENOG4105C37 (CBS) domain S101267_03262 ENOG4107PBV potassium channel S101267_03263 ENOG4107PBV potassium channel S101267_03266 ENOG4107QYV phosphohexose isomerase S101267_03268 ENOG4107QW4 alcohol dehydrogenase S101267_03269 ENOG4105WG9 Conserved Protein S101267_03271 ENOG4105CHM Aminotransferase S101267_03272 ENOG4108ZB6 transcriptional regulator AsnC family S101267_03273 ENOG4108MUZ hydrolase S101267_03275 ENOG4105C87 Aminotransferase class I and II S101267_03276 ENOG4108HGU Histidine kinase S101267_03277 ENOG4105Y38 Kinase-associated protein B S101267_03280 ENOG4105BZ4 penicillin-binding protein S101267_03281 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S101267_03284 ENOG4108MRH transcriptional regulatory protein S101267_03285 ENOG4105DIH basic membrane S101267_03286 ENOG4108JQ9 ABC transporter S101267_03287 ENOG4105UIB (ABC) transporter S101267_03290 ENOG4105D65 subunit l S101267_03291 ENOG4105HC0 Na H antiporter S101267_03292 ENOG4108ZE9 Monovalent cation H antiporter subunit C S101267_03293 ENOG4108JPZ Monovalent cation H antiporter subunit D S101267_03294 ENOG4105SC1 monovalent cation H antiporter subunit E S101267_03296 ENOG4105KJM monovalent cation h antiporter subunit g S101267_03297 ENOG4105KA0 thioesterase Superfamily protein S101267_03299 ENOG4105BZU Histidine kinase S101267_03304 ENOG4105D58 Diguanylate phosphodiesterase S101267_03305 ENOG4105DAP Nicotinate phosphoribosyltransferase S101267_03310 ENOG4105C02 permease S101267_03313 ENOG410904N short-chain dehydrogenase reductase S101267_03320 ENOG4108K8K Transcriptional regulator S101267_03321 ENOG4105DCF alanine dehydrogenase S101267_03323 ENOG4105WQT MbtH domain protein S101267_03324 ENOG4105CEY Amp-dependent synthetase and ligase S101267_03325 ENOG4105WQI isochorismatase S101267_03326 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S101267_03327 ENOG4105E4F Isochorismate synthase S101267_03328 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S101267_03329 ENOG4105NIV Esterase S101267_03333 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S101267_03335 ENOG41069ER domain protein S101267_03337 ENOG4105CEP NADH dehydrogenase S101267_03340 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) S101267_03343 ENOG4105CJ1 ABC, transporter S101267_03347 ENOG4105D9U N-acetyltransferase S101267_03348 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S101267_03349 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S101267_03350 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) S101267_03352 ENOG4105ZKE UPF0349 protein S101267_03355 ENOG41083MR nifu domain-containing protein S101267_03356 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S101267_03357 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S101267_03358 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S101267_03359 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S101267_03360 ENOG4105D6E homoserine dehydrogenase S101267_03362 ENOG4108W5N phosphatidylglycerophosphatase a S101267_03363 ENOG4105D4U had-superfamily hydrolase, subfamily iia S101267_03365 ENOG4105MMD transcriptional regulator S101267_03366 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S101267_03367 ENOG4105FAA peptidase M23 S101267_03368 ENOG4108YTE sporulation protein YunB S101267_03369 ENOG4107R8B 5'-nucleotidase S101267_03371 ENOG4105I3N Conserved Protein S101267_03373 ENOG4105CD3 dihydroorotase S101267_03374 ENOG4105G9B Transcriptional regulator S101267_03377 ENOG4105C5R Aminotransferase S101267_03379 ENOG4108K8S endonuclease I S101267_03380 ENOG4108IJ9 (ABC) transporter S101267_03381 ENOG4105FDP GntR family transcriptional regulator S101267_03382 ENOG4108KPW sugar kinase S101267_03383 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S101267_03384 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S101267_03385 ENOG4105XN3 extracellular solute-binding protein family 1 S101267_03386 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine S101267_03392 ENOG4105PKS Excinuclease abc c subunit domain protein S101267_03393 ENOG4107VFR oxidoreductase S101267_03394 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S101267_03396 ENOG41083Q9 chitosanase S101267_03397 ENOG4105DIW FeS assembly protein SUFB S101267_03398 ENOG4108UNV SUF system FeS assembly protein, NifU family S101267_03399 ENOG4105C9B Cysteine desulfurase S101267_03400 ENOG4105JRK feS assembly protein SufD S101267_03401 ENOG4105C3K feS assembly ATPase SufC S101267_03404 ENOG4105D01 (LipO)protein S101267_03405 ENOG4108UMI ABC transporter, permease S101267_03406 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S101267_03411 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) S101267_03412 ENOG41080E8 Transcriptional regulator, Spx MgsR family S101267_03413 ENOG4105C1G acyl-Coa dehydrogenase S101267_03414 ENOG4105CHU acetyl-coa acetyltransferase S101267_03420 ENOG41067TZ transcriptional regulator, MarR family S101267_03421 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101267_03426 ENOG4105E0A ABC, transporter S101267_03429 ENOG4105E1F short-chain dehydrogenase reductase S101267_03430 ENOG4105HUF DNA protection during starvation protein S101267_03431 ENOG4105C0H protease S101267_03433 ENOG4105F3H Histidine kinase S101267_03435 ENOG41067SE Tetr family transcriptional regulator S101267_03436 ENOG4105C9Q fumarate hydratase class II S101267_03441 ENOG4105WH1 Two component transcriptional regulator luxr family S101267_03442 ENOG4105ENE Histidine kinase S101267_03445 ENOG41087YS Phage shock protein A S101267_03448 ENOG4108WBT adenosyltransferase S101267_03449 ENOG4105E0A ABC, transporter S101267_03450 ENOG4105EHG Permease protein S101267_03451 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) S101267_03452 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101267_03453 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein S101267_03455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101267_03457 ENOG4106DF4 Sigma-70, region 4 S101267_03459 ENOG4105F0F Oxalate decarboxylase S101267_03461 ENOG4105E0A ABC, transporter S101267_03462 ENOG4105EHG Permease protein S101267_03463 ENOG4105DQ5 transport system permease protein S101267_03465 ENOG4105JQZ Methyltransferase S101267_03466 ENOG4105D5Q Arginine ornithine antiporter S101267_03468 ENOG4107K5X Membrane-bound metal-dependent hydrolase S101267_03469 ENOG4107QZ2 Sulfatase S101267_03470 ENOG4107QZ2 Sulfatase S101267_03471 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family S101267_03472 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein S101267_03473 ENOG4105E0C molybdate abc transporter S101267_03474 ENOG4105WH1 Two component transcriptional regulator luxr family S101267_03476 ENOG4105CJ1 ABC, transporter S101267_03478 ENOG4108KYE ABC-2 type transporter S101267_03481 ENOG4105EEQ Na H antiporter S101267_03482 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) S101267_03483 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101267_03484 ENOG4105EEM helicase S101267_03485 ENOG4105EEM helicase S101267_03486 ENOG4105EN6 Membrane S101267_03489 ENOG4107ZQN disulfide bond S101267_03490 ENOG4105C59 p-type ATPase S101267_03491 ENOG4105C59 p-type ATPase S101267_03492 ENOG410681U heavy metal transport detoxification protein S101267_03493 ENOG4105VPX protein, conserved in bacteria S101267_03494 ENOG4105D9R oxidoreductase S101267_03495 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S101267_03498 ENOG4105DEN Luciferase family S101267_03499 ENOG4105CDA abc transporter atp-binding protein S101267_03504 ENOG4108XSB acetyltransferase, (GNAT) family S101267_03505 ENOG4108KSA LysR family transcriptional regulator S101267_03506 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101267_03507 ENOG41067XF inhibitor S101267_03508 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) S101267_03509 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) S101267_03511 ENOG4105XZU Preprotein translocase, subunit SecG S101267_03515 ENOG4105KVH Transcriptional regulator S101267_03520 ENOG4105DA5 (ABC) transporter S101267_03521 ENOG4105R40 Glycine betaine carnitine choline S101267_03522 ENOG4108HQR Glycine betaine S101267_03523 ENOG4105E90 ABC transporter S101267_03524 ENOG4108IJ8 ABC transporter S101267_03525 ENOG4107HG4 Transcriptional regulator S101267_03526 ENOG4105R40 Glycine betaine carnitine choline S101267_03527 ENOG4108HQR Glycine betaine S101267_03528 ENOG4105E90 ABC transporter S101267_03529 ENOG4108IJ8 ABC transporter S101267_03530 ENOG4107HG4 Transcriptional regulator S101267_03531 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein S101267_03533 ENOG4105T65 Membrane-associated protein S101267_03534 ENOG4108W0I acetyltransferase S101267_03537 ENOG4105FJR Lmbe family S101267_03541 ENOG4108IAJ Nad-dependent epimerase dehydratase S101267_03542 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101267_03543 ENOG4107QQG Dehydrogenase S101267_03544 ENOG4105IIU Aminopeptidase S101267_03545 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) S101267_03546 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) S101267_03547 ENOG4105CP7 Triose-phosphate isomerase S101267_03548 ENOG4105BZA Phosphoglycerate kinase S101267_03549 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101267_03553 ENOG4105CMD Transcriptional regulator, GntR family S101267_03554 ENOG4105DEN Luciferase family S101267_03555 ENOG4105GZI Transcriptional regulator S101267_03556 ENOG4105GZI Transcriptional regulator S101267_03557 ENOG4107RT3 EamA-like transporter family S101267_03560 ENOG4106KNT transcriptional regulator S101267_03561 ENOG4105CMG Carbohydrate kinase S101267_03562 ENOG4105C6Z Gluconate S101267_03564 ENOG4107QR9 Iron-sulfur cluster binding protein S101267_03565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101267_03566 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101267_03567 ENOG4105JXH GntR family transcriptional regulator S101267_03568 ENOG4105DAA L-lactate S101267_03569 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101267_03571 ENOG4108ZPC Polysaccharide pyruvyl transferase S101267_03572 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101267_03573 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family S101267_03574 ENOG4105D3Q Sugar transferase S101267_03576 ENOG4105K64 Glycosyl transferase, family 2 S101267_03578 ENOG4107QRS glycosyltransferase group 2 family protein S101267_03579 ENOG41068W6 Capsular polysaccharide biosynthesis protein S101267_03580 ENOG4108KMV Glycosyl transferase (Group 1 S101267_03581 ENOG4105K64 Glycosyl transferase, family 2 S101267_03582 ENOG4108PQP glycosyl transferase group 1 S101267_03584 ENOG4108QV3 biosynthesis protein S101267_03585 ENOG4105HTX biosynthesis protein S101267_03587 ENOG4105EBR Carboxylesterase S101267_03589 ENOG4105NAE bifunctional deaminase-reductase domain protein S101267_03590 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) S101267_03593 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 S101267_03594 ENOG4105PY6 Phenolic acid decarboxylase S101267_03595 ENOG4105NI3 Protein of unknown function (DUF3237) S101267_03602 ENOG4108HKT sucrose-6-phosphate hydrolase S101267_03603 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) S101267_03604 ENOG4105ETE Transcriptional regulator (LacI family S101267_03605 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101267_03606 ENOG4108KAM Transcriptional regulator S101267_03607 ENOG4105C7F AcnD-accessory protein PrpF S101267_03610 ENOG4108URH decarboxylase S101267_03611 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain S101267_03612 ENOG4105CHH sulfate transporter S101267_03613 ENOG4108V2W Carbonate dehydratase S101267_03614 ENOG4105C5I Dehydrogenase S101267_03615 ENOG4105GGE ribonuclease S101267_03616 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase S101267_03617 ENOG4105KRI phosphocarrier protein (HPr S101267_03618 ENOG4105CIE May be required for sporulation (By similarity) S101267_03619 ENOG4105CHW UPF0052 protein S101267_03620 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) S101267_03621 ENOG4108Z4K mutator MutT protein S101267_03622 ENOG4105C3M thioredoxin reductase S101267_03625 ENOG4105BZU Histidine kinase S101267_03626 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_03627 ENOG4105BZ1 (ABC) transporter S101267_03628 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase S101267_03629 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) S101267_03630 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase S101267_03631 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) S101267_03632 ENOG4105ECC imidazole-glycerol-phosphate dehydratase S101267_03633 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) S101267_03634 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) S101267_03635 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) S101267_03637 ENOG4108S4C acetyltransferase S101267_03638 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) S101267_03640 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) S101267_03641 ENOG4105CE4 GlcNAc 6-P deacetylase S101267_03642 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S101267_03643 ENOG4105FDP GntR family transcriptional regulator S101267_03644 ENOG4105J7D transcriptional regulator S101267_03645 ENOG41088CQ domain protein S101267_03646 ENOG41086DT Membrane protein of unknown function S101267_03647 ENOG41067S9 phage shock protein C, PspC S101267_03648 ENOG4108PY7 S101267_03651 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) S101267_03652 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) S101267_03656 ENOG4105MKU Transcriptional regulator S101267_03662 ENOG4105CN1 protease S101267_03663 ENOG4108M26 parallel beta-helix repeat protein S101267_03664 ENOG4105CRP Part of the ABC transporter FtsEX involved in S101267_03665 ENOG4105CAK Cell division ATP-binding protein ftsE S101267_03668 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) S101267_03669 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving S101267_03670 ENOG4105MS2 ribosomal subunit Interface protein S101267_03673 ENOG4105MQ3 flagellar protein FliS S101267_03674 ENOG4107RT6 flagellar hook-associated S101267_03675 ENOG4105I03 Flagellin S101267_03676 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) S101267_03677 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) S101267_03679 ENOG4105DTJ flagellar hook-associated protein S101267_03680 ENOG4105E1Q flagellar hook-associated protein S101267_03683 ENOG4105RU3 S101267_03684 ENOG41081UC Inherit from COG: Competence protein S101267_03688 ENOG4105WH1 Two component transcriptional regulator luxr family S101267_03689 ENOG4105BZU Histidine kinase S101267_03690 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein S101267_03691 ENOG4108KGH TRANSCRIPTIONal S101267_03692 ENOG4105ESV Glycosyl transferase, family 4 S101267_03693 ENOG4107EF8 Glycosyl transferase (Group 1 S101267_03696 ENOG4105QZI O-Antigen Polymerase S101267_03697 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101267_03698 ENOG4107RA4 Glycosyl transferase (Group 1 S101267_03699 ENOG4105PSV Polysaccharide Biosynthesis Protein S101267_03700 ENOG4105D3Q Sugar transferase S101267_03701 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101267_03702 ENOG4105JFG SpoIID LytB domain protein S101267_03704 ENOG4108KGH TRANSCRIPTIONal S101267_03705 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S101267_03706 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101267_03707 ENOG4105EY8 ABC transporter S101267_03709 ENOG4107SJB teichoic acid biosynthesis S101267_03710 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) S101267_03711 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase S101267_03713 ENOG4107RZX Teichoic acid biosynthesis protein S101267_03715 ENOG4105DG6 mannose-6-phosphate isomerase S101267_03718 ENOG4108NHD germination protein S101267_03719 ENOG4108SHN Glycosyl transferase, family 2 S101267_03720 ENOG4105C54 Major Facilitator superfamily S101267_03721 ENOG4108KGH TRANSCRIPTIONal S101267_03722 ENOG4105J7I hydrolase S101267_03723 ENOG4106UBQ S101267_03724 ENOG4105K4H Nlp p60 protein S101267_03726 ENOG4105PNM synthesis protein S101267_03728 ENOG4105N98 Capsule biosynthesis protein capB S101267_03733 ENOG4105ETE Transcriptional regulator (LacI family S101267_03734 ENOG4108RVA ribokinase S101267_03735 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) S101267_03736 ENOG4105C2J ABC transporter S101267_03737 ENOG4105CNN ABC, transporter S101267_03738 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S101267_03740 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S101267_03741 ENOG4107FQX Alpha-acetolactate decarboxylase S101267_03743 ENOG4107RSM transcriptional regulator S101267_03746 ENOG4106UIA S101267_03749 ENOG4107XC4 flavin reductase domain protein, FMN-binding S101267_03751 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101267_03753 ENOG4105CAH Chromate S101267_03754 ENOG4105FGV Chromate S101267_03763 ENOG4108XI2 Domain of unknown function (DUF1963) S101267_03764 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101267_03765 ENOG4108RB3 Capsular polysaccharide biosynthesis protein S101267_03766 ENOG4107YJ4 chain length determinant protein S101267_03767 ENOG4105HTX biosynthesis protein S101267_03769 ENOG4105KBK Zinc finger, swim domain protein S101267_03770 ENOG4105C0D helicase S101267_03771 ENOG410667J hydrolase S101267_03772 ENOG4105E98 transcriptional regulator DeoR family S101267_03773 ENOG4105Z8H single-stranded DNA-binding protein S101267_03776 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) S101267_03777 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) S101267_03779 ENOG4105CGA flagellar basal-body rod protein FlgG S101267_03781 ENOG4105DFF Rod shape-determining protein mreb S101267_03782 ENOG4105MT0 Sporulation transcriptional regulator spoiiid S101267_03783 ENOG4107MII Sugar-specific transcriptional regulator TrmB S101267_03784 ENOG4105CZM Major Facilitator S101267_03785 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S101267_03786 ENOG41080V3 Major Facilitator superfamily S101267_03787 ENOG4105D3W isochorismatase S101267_03788 ENOG4105BZU Histidine kinase S101267_03790 ENOG4105CNI cell division protein FtsW S101267_03791 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase S101267_03793 ENOG4105FRN stage II sporulation protein S101267_03794 ENOG4107TCE N-acetyltransferase S101267_03797 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101267_03799 ENOG4106BRK S101267_03800 ENOG4108RYK Nad-dependent epimerase dehydratase S101267_03801 ENOG4108Z40 Transcriptional regulator S101267_03802 ENOG4105CQM Urea amidohydrolase subunit alpha S101267_03803 ENOG4105KI2 Urea amidohydrolase subunit beta S101267_03804 ENOG4108YZ9 Urea amidohydrolase subunit gamma S101267_03808 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S101267_03809 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) S101267_03811 ENOG4108TF4 von Willebrand factor, type A S101267_03814 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101267_03816 ENOG4106778 Protein of unknown function (DUF1146) S101267_03818 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) S101267_03819 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) S101267_03820 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) S101267_03821 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) S101267_03822 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) S101267_03825 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) S101267_03827 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) S101267_03828 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S101267_03829 ENOG4108UIC UPF0340 protein S101267_03830 ENOG4108YZG isomerase S101267_03831 ENOG4107WAU Protein tyrosine phosphatase S101267_03832 ENOG410815N Probably functions as a manganese efflux pump (By similarity) S101267_03833 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101267_03835 ENOG4108ZXQ stage ii sporulation protein r S101267_03838 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) S101267_03839 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) S101267_03840 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase S101267_03842 ENOG4107TT2 Auxin Efflux Carrier S101267_03843 ENOG4105C6K Malic enzyme S101267_03844 ENOG4107104 thymidine kinase S101267_03845 ENOG41082DI 50s ribosomal protein l31 S101267_03846 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) S101267_03847 ENOG4105CBT Fructose-1,6-bisphosphatase S101267_03848 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101267_03850 ENOG4105D2N Aldolase S101267_03851 ENOG410812K response regulator receiver protein S101267_03853 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) S101267_03855 ENOG4105DF6 Fe-S oxidoreductase S101267_03857 ENOG4105E5J UV damage endonuclease S101267_03859 ENOG4105BZ1 (ABC) transporter S101267_03860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101267_03862 ENOG4105R3A Nitrate reductase S101267_03863 ENOG4108IUE nitrate reductase beta subunit S101267_03867 ENOG4107V6Q Cyclic nucleotide-binding domain S101267_03869 ENOG4105C75 arginyL-tRNA synthetase S101267_03870 ENOG410684U Domain of unknown function (DUF1934) S101267_03873 ENOG4107JM4 Tetratricopeptide repeat S101267_03875 ENOG4105CYW agmatinase S101267_03876 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) S101267_03877 ENOG4105BZ4 penicillin-binding protein S101267_03879 ENOG4108XFG YwhD family S101267_03880 ENOG4108Z4T Peptidase M50 S101267_03881 ENOG41069HH 4-oxalocrotonate tautomerase S101267_03882 ENOG41067TZ transcriptional regulator, MarR family S101267_03883 ENOG4105CUB amino acid S101267_03885 ENOG4105DCI Phosphohydrolase S101267_03887 ENOG4108VCI transcription factor, rsfa family S101267_03888 ENOG4105K7K Transcriptional regulator S101267_03890 ENOG4105CJ1 ABC, transporter S101267_03891 ENOG4108TU7 Inherit from COG: (ABC) transporter S101267_03896 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) S101267_03897 ENOG4105DUM transcriptional regulator, lysR family S101267_03898 ENOG4105HMI Membrane S101267_03899 ENOG4108IJ2 phosphate acetyltransferase S101267_03900 ENOG4107JTW chlorite dismutase S101267_03904 ENOG4105CHM Aminotransferase S101267_03906 ENOG4108M32 ATP-grasp domain S101267_03909 ENOG41061WN bacilysin biosynthesis protein S101267_03910 ENOG4105FCW Major Facilitator superfamily S101267_03911 ENOG4105C2C drug resistance transporter, Bcr CflA S101267_03914 ENOG4105C26 Dehydrogenase S101267_03915 ENOG4105D82 Glutamate dehydrogenase S101267_03917 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase S101267_03918 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase S101267_03919 ENOG4105C1B dTDP-glucose 4-6-dehydratase S101267_03920 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) S101267_03921 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG S101267_03922 ENOG4107TY6 Acylneuraminate cytidylyltransferase S101267_03924 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD S101267_03925 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101267_03932 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) S101267_03933 ENOG4108RJ9 Glycosyl transferase, family 2 S101267_03935 ENOG4105DWF phosphomethylpyrimidine kinase S101267_03938 ENOG4105C5Y PTS System S101267_03941 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin S101267_03942 ENOG4105DEN Luciferase family S101267_03943 ENOG4105D29 Helix-turn-helix type 11 domain protein S101267_03944 ENOG4107EXU Short-chain dehydrogenase reductase Sdr S101267_03947 ENOG4108DBC nitroreductase S101267_03949 ENOG4105I4A GCN5-related N-acetyltransferase S101267_03953 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101267_03954 ENOG4105E2S oxidase) subunit II S101267_03955 ENOG4107BMA Transglycosylase associated protein S101267_03957 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) S101267_03958 ENOG4105WH5 Teichoic acid glycosylation protein S101267_03961 ENOG4105DWV Homoserine O-trans-acetylase S101267_03963 ENOG4107ZXU DSBA oxidoreductase S101267_03964 ENOG4105DBE peroxidase S101267_03965 ENOG410650H (LipO)protein S101267_03966 ENOG4107SJW iron permease, FTR1 S101267_03967 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) S101267_03968 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase S101267_03969 ENOG4105CMU LysR family (Transcriptional regulator S101267_03970 ENOG4105VAW lrga family S101267_03971 ENOG41067MG lrgb family S101267_03973 ENOG4107TXC Transcriptional regulator S101267_03975 ENOG4105DR4 Methyltransferase S101267_03977 ENOG4105CK1 PTS System S101267_03978 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin S101267_03979 ENOG4105X1N Glycosyl transferase family 8 S101267_03980 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101267_03982 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase S101267_03984 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) S101267_03985 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein S101267_03986 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) S101267_03987 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD S101267_03988 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101267_03989 ENOG4105F8D glycoside hydrolase family 4 S101267_03990 ENOG4105VCP PTS System S101267_03991 ENOG4105CK1 PTS System S101267_03992 ENOG4105VZJ PTS System S101267_03993 ENOG4105EMD TRANSCRIPTIONal S101267_03995 ENOG4105DQ5 transport system permease protein S101267_03996 ENOG4105EHG Permease protein S101267_03998 ENOG41082YX Transcriptional regulator, arsr family S101267_03999 ENOG4107R5R arsenical pump membrane protein S101267_04000 ENOG4105VZJ PTS System S101267_04001 ENOG4105VCP PTS System S101267_04002 ENOG4105CK1 PTS System S101267_04003 ENOG4105CS2 ec 3.2.1.21 S101267_04004 ENOG4105EVU fructokinase S101267_04005 ENOG4105DG6 mannose-6-phosphate isomerase S101267_04007 ENOG4105CH6 catalase S101267_04008 ENOG4107QHE Choloylglycine hydrolase S101267_04009 ENOG4105ETS cytosine purines uracil thiamine allantoin S101267_04010 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S101267_04011 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S101267_04012 ENOG4108JJ8 (ABC) transporter S101267_04013 ENOG4108JJ9 ABC, transporter S101267_04014 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii S101267_04015 ENOG4105C4M (Ubiquinol oxidase) subunit I S101267_04016 ENOG4105D2K citrate carrier protein S101267_04017 ENOG4107BJW polysaccharide deacetylase S101267_04020 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) S101267_04023 ENOG4105CMR udp-glucose 4-epimerase S101267_04024 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101267_04029 ENOG4105DHI Methyltransferase S101267_04034 ENOG4105CH6 catalase S101267_04035 ENOG4105D4T Citrate transporter S101267_04037 ENOG4105CID antiterminator S101267_04038 ENOG4105DEU major facilitator superfamily S101267_04039 ENOG4105C1J atp-dependent rna helicase S101267_04048 ENOG4108NR7 pectate lyase S101267_04050 ENOG4107YZX Universal stress protein S101267_04051 ENOG4105CS2 ec 3.2.1.21 S101267_04052 ENOG4105C5Y PTS System S101267_04055 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S101267_04059 ENOG4106Z5D Glycoside Hydrolase Family 43 S101267_04061 ENOG4105C84 Histidine ammonia-lyase S101267_04062 ENOG4105CGP Urocanate hydratase S101267_04063 ENOG4105CI2 imidazolone-5-propionate hydrolase S101267_04064 ENOG4107W25 arginase agmatinase formiminoglutamase S101267_04066 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) S101267_04067 ENOG4105D9N nucleoside S101267_04068 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) S101267_04069 ENOG4107RHR regulatoR S101267_04070 ENOG410667J hydrolase S101267_04077 ENOG4108V5C ABC transporter S101267_04084 ENOG4105WZ4 isomerase S101267_04085 ENOG4105F0H myo-inositol catabolism protein S101267_04086 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101267_04088 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S101267_04090 ENOG4105EDK PfkB domain protein S101267_04092 ENOG4105C26 Dehydrogenase S101267_04094 ENOG4105CPC Aldo Keto reductase S101267_04095 ENOG4107QNK )-transporter S101267_04096 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) S101267_04097 ENOG41061TZ Short-chain dehydrogenase reductase Sdr S101267_04098 ENOG4108S01 response regulator S101267_04099 ENOG4108ZGX Histidine kinase S101267_04100 ENOG4105ECK Fatty Acid Desaturase S101267_04101 ENOG4105ST3 Transcriptional regulator S101267_04102 ENOG4105C26 Dehydrogenase S101267_04103 ENOG4108ITS PQQ enzyme repeat S101267_04105 ENOG4105WAB arsR family transcriptional regulator S101267_04106 ENOG4105F27 Major Facilitator S101267_04107 ENOG41085PJ rdd domain containing protein S101267_04109 ENOG4105D3R alkyl hydroperoxide reductase S101267_04110 ENOG4108JU3 Alkyl hydroperoxide reductase S101267_04112 ENOG4105C85 amino acid S101267_04122 ENOG41090VF Stage v sporulation protein ac S101267_04123 ENOG4105CZ3 stage V sporulation protein ad S101267_04126 ENOG4108QY0 Membrane S101267_04128 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101267_04129 ENOG4105H67 Protein of unknown function (DUF421) S101267_04130 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 S101267_04131 ENOG4108XHQ (2Fe-2S)-binding domain protein S101267_04133 ENOG4105C7W Xanthine dehydrogenase S101267_04135 ENOG4105XRQ Xanthine dehydrogenase accessory factor S101267_04140 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) S101267_04145 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) S101267_04146 ENOG4105CPC Aldo Keto reductase S101267_04147 ENOG4105WQG acetyltransferase S101267_04150 ENOG41066UZ arginase EC 3.5.3.1 S101267_04151 ENOG4108IQI permease S101267_04152 ENOG4105C8Y Acetylornithine aminotransferase S101267_04154 ENOG41082BM Transcriptional regulator, arsr family S101267_04155 ENOG4108JUB Transcriptional regulator S101267_04158 ENOG41062D9 Histidine kinase S101267_04159 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_04161 ENOG4105C0H protease S101267_04162 ENOG4105Q2H domain protein S101267_04165 ENOG4105BZU Histidine kinase S101267_04166 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101267_04171 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis S101267_04172 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase S101267_04173 ENOG4105CDU Replicative dna helicase S101267_04179 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR S101267_04180 ENOG4105CPK Glycosyl transferase (Group 1 S101267_04184 ENOG4105BZR domain protein S101267_04185 ENOG4108XMW Membrane S101267_04187 ENOG4105KVH Transcriptional regulator S101267_04188 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase S101267_04189 ENOG4108UZ3 Transporter S101267_04190 ENOG4105EDQ levansucrase EC 2.4.1.10 S101267_04191 ENOG4108HKT sucrose-6-phosphate hydrolase S101267_04196 ENOG4108TVJ Nitroreductase S101267_04197 ENOG4105FS7 Transcriptional regulator S101267_04199 ENOG4108U05 Transcriptional regulator S101267_04200 ENOG41082BV acetyltransferase S101267_04201 ENOG41085FC arsR family transcriptional regulator S101267_04209 ENOG4105K4H Nlp p60 protein S101267_04211 ENOG4105P1M Domain of unknown function (DUF1874) S101267_04221 ENOG4106128 DNA-binding helix-turn-helix protein S101267_04222 ENOG4106BHR ftsk SpoIIIE family protein S101267_04223 ENOG4106BHR ftsk SpoIIIE family protein S101267_04225 ENOG4108RYM conjugative transposon protein S101267_04229 ENOG4108IMY Transcriptional regulator S101267_04230 ENOG41068WC Domain of unknown function (DUF955) S101267_04233 ENOG4105C7Z Conserved Protein S101267_04234 ENOG4105C7Z Conserved Protein S101267_04235 ENOG4105C7Z Conserved Protein S101267_04236 ENOG4107FCW Abortive infection protein S101267_04238 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase S101267_04241 ENOG4105CGK Exodeoxyribonuclease III S101267_04242 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101267_04244 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) S101267_04245 ENOG4108UUM single-stranded DNA-binding protein S101267_04246 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) S101267_04247 ENOG4105C3G gtp-binding protein S101267_04248 ENOG4108J2R molybdopterin oxidoreductase S101267_04249 ENOG4105VDK protein, conserved in bacteria S101267_04252 ENOG4108ZDA Sporulation protein YyaC S101267_04253 ENOG4105FA0 parb-like partition protein S101267_04254 ENOG4107QJE Chromosome Partitioning Protein S101267_04257 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) S101267_04258 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) S101267_04261 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) S101267_04262 ENOG4105FTQ Dna gyrase S101267_04273 ENOG4105E0X reductase S101267_04274 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) S101267_04276 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S101267_04277 ENOG41090WU lipolytic protein G-D-S-L family S101267_04278 ENOG4108KF3 Electron transport protein SCO1 SenC S101267_04280 ENOG4105C7B Threonine dehydratase S101267_04281 ENOG4105C7B Threonine dehydratase S101267_04282 ENOG4105C7B Threonine dehydratase S101267_04284 ENOG4108UT2 hemolysin iii S101267_04285 ENOG4108UT2 hemolysin iii S101267_04287 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S101267_04288 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S101267_04289 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)