locus-tag	class	description
PF976_00005	COG1982	Orn Lys Arg decarboxylase major
PF976_00015	COG3870	Protein conserved in bacteria
PF976_00020	COG1728	Protein conserved in bacteria
PF976_00025	COG0470	DNA polymerase III
PF976_00030	COG1774	PSP1 C-terminal conserved region
PF976_00040	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PF976_00050	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PF976_00055	COG2002	toxin-antitoxin pair type II binding
PF976_00060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF976_00060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF976_00065	COG0084	hydrolase, TatD family'
PF976_00070	COG3583	domain protein
PF976_00070	COG3584	3D domain protein
PF976_00075	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF976_00080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF976_00090	COG4466	Protein conserved in bacteria
PF976_00105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF976_00110	COG0251	oxidation-reduction process
PF976_00125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF976_00145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF976_00150	COG2002	toxin-antitoxin pair type II binding
PF976_00155	COG2244	polysaccharide biosynthetic process
PF976_00160	COG3956	TIGRFAM MazG family protein
PF976_00165	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF976_00180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF976_00185	COG1098	S1 RNA binding domain
PF976_00200	COG2208	phosphoserine phosphatase activity
PF976_00205	COG2304	oxidoreductase activity
PF976_00210	COG0515	serine threonine protein kinase
PF976_00215	COG0037	tRNA processing
PF976_00220	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PF976_00225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF976_00240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF976_00245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF976_00250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF976_00255	COG0512	Glutamine amidotransferase of anthranilate synthase
PF976_00260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF976_00265	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF976_00270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF976_00275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF976_00280	COG1396	sequence-specific DNA binding
PF976_00285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF976_00290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PF976_00370	COG4463	regulation of RNA biosynthetic process
PF976_00375	COG3880	PFAM UvrB UvrC protein
PF976_00385	COG0542	response to heat
PF976_00390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PF976_00395	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PF976_00400	COG4956	integral membrane protein (PIN domain superfamily)
PF976_00420	COG1045	serine acetyltransferase
PF976_00430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PF976_00435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF976_00440	COG3688	RNA-binding protein containing a PIN domain
PF976_00445	COG1595	DNA-templated transcription, initiation
PF976_00455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF976_00460	COG0250	Participates in transcription elongation, termination and antitermination
PF976_00485	COG2813	Specifically methylates the guanine in position
PF976_00500	COG1358	cellular component organization or biogenesis
PF976_00525	COG0596	Alpha beta hydrolase
PF976_00635	COG0201	protein transport
PF976_00645	COG0024	Methionine aminopeptidase
PF976_00660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF976_00685	COG1122	ATPase activity
PF976_00690	COG1122	ATPase activity
PF976_00695	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF976_00705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PF976_00715	COG2226	methyltransferase
PF976_00725	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF976_00730	COG0489	protein tyrosine kinase activity
PF976_00740	COG2194	sulfuric ester hydrolase activity
PF976_00745	COG0726	polysaccharide deacetylase
PF976_00805	COG0738	Major facilitator superfamily
PF976_00810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF976_00825	COG0659	secondary active sulfate transmembrane transporter activity
PF976_00830	COG0385	Bile acid
PF976_00835	COG2819	hydrolase of the alpha beta superfamily
PF976_00840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_00845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_00850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF976_00855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF976_00855	COG2207	Transcriptional regulator
PF976_00860	COG3876	Protein conserved in bacteria
PF976_00865	COG1472	Belongs to the glycosyl hydrolase 3 family
PF976_00870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF976_00875	COG1263	PTS System
PF976_00875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_00885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF976_00890	COG1683	Conserved Protein
PF976_00920	COG1595	DNA-templated transcription, initiation
PF976_00925	COG5662	AntiSigma factor
PF976_00930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF976_00935	COG4856	YbbR-like protein
PF976_00985	COG1346	cytolysis
PF976_00990	COG1380	Effector of murein hydrolase LrgA
PF976_00995	COG1846	Transcriptional regulator
PF976_01000	COG1113	amino acid transport
PF976_01005	COG1011	Hydrolase
PF976_01010	COG4585	Histidine kinase
PF976_01015	COG2197	response regulator
PF976_01020	COG1131	(ABC) transporter
PF976_01030	COG0842	Transport permease protein
PF976_01030	COG1511	domain protein
PF976_01070	COG0584	glycerophosphoryl diester phosphodiesterase
PF976_01075	COG2271	Major facilitator Superfamily
PF976_01085	COG2368	4-hydroxyphenylacetate
PF976_01095	COG0371	Dehydrogenase
PF976_01105	COG1183	phosphatidylcholine synthase activity
PF976_01110	COG0586	Pfam SNARE associated Golgi protein
PF976_01115	COG0688	phosphatidylethanolamine metabolic process
PF976_01130	COG1301	dicarboxylic acid transport
PF976_01135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF976_01140	COG0833	amino acid
PF976_01145	COG2040	homocysteine
PF976_01150	COG1115	amino acid carrier protein
PF976_01160	COG4191	Histidine kinase
PF976_01165	COG0784	Response regulator, receiver
PF976_01170	COG3173	Aminoglycoside phosphotransferase
PF976_01185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF976_01200	COG2259	Doxx family
PF976_01205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_01220	COG3773	Cell wall hydrolase
PF976_01225	COG3540	Alkaline phosphatase
PF976_01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF976_01235	COG0805	protein transport
PF976_01240	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PF976_01245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF976_01250	COG0477	Major facilitator Superfamily
PF976_01255	COG1309	transcriptional regulator
PF976_01265	COG1405	negative regulation of cell septum assembly
PF976_01265	COG3012	SEC-C Motif Domain Protein
PF976_01270	COG0667	Aldo Keto reductase
PF976_01280	COG1595	DNA-templated transcription, initiation
PF976_01285	COG1595	DNA-templated transcription, initiation
PF976_01290	COG1876	peptidase activity
PF976_01295	COG0457	Tetratricopeptide repeat
PF976_01300	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_01305	COG0366	Alpha amylase catalytic
PF976_01315	COG1695	Transcriptional regulator
PF976_01320	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF976_01325	COG1121	(ABC) transporter
PF976_01330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF976_01335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_01340	COG2310	stress, protein
PF976_01345	COG2310	stress, protein
PF976_01350	COG2310	stress, protein
PF976_01355	COG0861	Integral membrane protein TerC family
PF976_01365	COG3853	Toxic anion resistance protein (TelA)
PF976_01370	COG0477	Major facilitator Superfamily
PF976_01375	COG4175	Glycine betaine
PF976_01375	COG0517	IMP dehydrogenase activity
PF976_01380	COG4176	ABC-type proline glycine betaine transport system permease component
PF976_01385	COG2113	Glycine betaine
PF976_01390	COG1473	amidohydrolase
PF976_01395	COG1288	antiporter activity
PF976_01405	COG1714	RDD family
PF976_01415	COG2814	Major facilitator Superfamily
PF976_01420	COG1846	Transcriptional regulator
PF976_01425	COG1280	lysine exporter protein (LysE YggA)
PF976_01435	COG1113	amino acid transport
PF976_01450	COG1082	Xylose isomerase domain protein TIM barrel
PF976_01455	COG2271	Major facilitator Superfamily
PF976_01460	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PF976_01465	COG3458	cephalosporin-C deacetylase activity
PF976_01470	COG3541	Predicted nucleotidyltransferase
PF976_01475	COG0506	proline dehydrogenase activity
PF976_01480	COG1012	belongs to the aldehyde dehydrogenase family
PF976_01485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF976_01490	COG2508	Transcriptional regulator
PF976_01500	COG1587	Uroporphyrinogen-III synthase
PF976_01500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF976_01505	COG2146	nitrite reductase [NAD(P)H] activity
PF976_01510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF976_01520	COG0523	cobalamin synthesis protein
PF976_01525	COG1063	alcohol dehydrogenase
PF976_01530	COG1714	RDD family
PF976_01540	COG2723	6-phospho-beta-galactosidase activity
PF976_01550	COG3209	COG3209 Rhs family protein
PF976_01555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF976_01560	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PF976_01565	COG1733	regulation of RNA biosynthetic process
PF976_01570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_01585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_01590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_01595	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF976_01610	COG2364	Membrane
PF976_01615	COG1126	abc transporter atp-binding protein
PF976_01620	COG0765	amino acid transport
PF976_01625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_01630	COG0583	DNA-binding transcription factor activity
PF976_01635	COG0163	prenyltransferase activity
PF976_01640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PF976_01655	COG3104	oligopeptide transport
PF976_01660	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_01670	COG0697	spore germination
PF976_01680	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF976_01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_01690	COG0456	acetyltransferase
PF976_01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_01700	COG0765	amino acid transport
PF976_01705	COG1126	abc transporter atp-binding protein
PF976_01710	COG1473	amidohydrolase
PF976_01715	COG2079	MmgE PrpD family protein
PF976_01720	COG1136	(ABC) transporter
PF976_01725	COG0577	efflux transmembrane transporter activity
PF976_01730	COG0745	RESPONSE REGULATOR receiver
PF976_01735	COG3850	Histidine kinase
PF976_01735	COG5002	protein histidine kinase activity
PF976_01740	COG0457	Tetratricopeptide repeat
PF976_01755	COG0527	aspartate kinase activity
PF976_01760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_01765	COG4605	iron ion homeostasis
PF976_01770	COG4604	ABC transporter, ATP-binding protein
PF976_01775	COG4607	ABC-type enterochelin transport system periplasmic component
PF976_01780	COG2814	Major facilitator Superfamily
PF976_01785	COG1309	transcriptional regulator
PF976_01790	COG0778	Nitroreductase
PF976_01795	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF976_01800	COG0640	Transcriptional regulator
PF976_01805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF976_01810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF976_01815	COG1012	belongs to the aldehyde dehydrogenase family
PF976_01820	COG4975	Glucose uptake
PF976_01825	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_01830	COG4549	nuclear export factor GLE1
PF976_01835	COG2372	response to copper ion
PF976_01835	COG1276	copper resistance
PF976_01840	COG1349	DNA-binding transcription factor activity
PF976_01850	COG2213	PTS system mannitol-specific
PF976_01855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_01865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF976_01875	COG0561	phosphatase activity
PF976_01885	COG1914	H( )-stimulated, divalent metal cation uptake system
PF976_01895	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PF976_01900	COG1984	allophanate hydrolase subunit 2
PF976_01905	COG1414	Transcriptional regulator
PF976_01910	COG2755	lipolytic protein G-D-S-L family
PF976_01920	COG2329	Antibiotic biosynthesis monooxygenase
PF976_01925	COG0768	penicillin binding
PF976_01930	COG4989	oxidoreductase activity
PF976_01935	COG3711	transcriptional antiterminator
PF976_01940	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_01950	COG1917	Cupin 2, conserved barrel domain protein
PF976_01955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF976_01960	COG3871	stress protein (general stress protein 26)
PF976_01970	COG2814	Major facilitator Superfamily
PF976_01975	COG1522	sequence-specific DNA binding
PF976_01980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF976_01980	COG0551	DNA topoisomerase type I activity
PF976_01985	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PF976_01990	COG3706	GGDEF domain
PF976_01995	COG5298	Protein conserved in bacteria
PF976_02000	COG1215	transferase activity, transferring glycosyl groups
PF976_02010	COG0531	amino acid
PF976_02045	COG0457	Tetratricopeptide repeat
PF976_02070	COG1914	H( )-stimulated, divalent metal cation uptake system
PF976_02090	COG2076	Multidrug Resistance protein
PF976_02095	COG2217	Heavy metal translocating P-type atpase
PF976_02100	COG3729	General stress protein
PF976_02105	COG0662	Cupin 2, conserved barrel domain protein
PF976_02110	COG2329	Antibiotic biosynthesis monooxygenase
PF976_02115	COG3546	catalase activity
PF976_02120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PF976_02125	COG3290	protein histidine kinase activity
PF976_02130	COG4565	transcriptional regulatory protein
PF976_02135	COG1301	dicarboxylic acid transport
PF976_02140	COG0628	permease
PF976_02145	COG1131	(ABC) transporter
PF976_02150	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF976_02175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF976_02180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_02190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF976_02195	COG0513	Belongs to the DEAD box helicase family
PF976_02200	COG3402	PFAM membrane-flanked domain
PF976_02205	COG3428	Bacterial PH domain
PF976_02210	COG0705	Rhomboid family
PF976_02220	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF976_02225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF976_02230	COG0864	Transcriptional regulator
PF976_02235	COG2337	Toxic component of a toxin-antitoxin (TA) module
PF976_02240	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_02245	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_02250	COG2172	sigma factor antagonist activity
PF976_02255	COG2208	phosphoserine phosphatase activity
PF976_02260	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_02270	COG1191	sigma factor activity
PF976_02275	COG2208	phosphoserine phosphatase activity
PF976_02280	COG2183	response to ionizing radiation
PF976_02335	COG1764	response to oxidative stress
PF976_02340	COG1846	Transcriptional regulator
PF976_02355	COG1959	2 iron, 2 sulfur cluster binding
PF976_02365	COG1278	Cold shock
PF976_02370	COG1794	racemase activity, acting on amino acids and derivatives
PF976_02385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF976_02390	COG0477	Major facilitator Superfamily
PF976_02395	COG3621	Patatin-like phospholipase
PF976_02405	COG0277	FAD linked oxidase domain protein
PF976_02425	COG0662	Cupin 2, conserved barrel domain protein
PF976_02430	COG0456	acetyltransferase
PF976_02435	COG3708	Transcriptional regulator
PF976_02435	COG2207	Transcriptional regulator
PF976_02460	COG1064	alcohol dehydrogenase
PF976_02465	COG0789	Transcriptional regulator
PF976_02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF976_02480	COG2808	Putative FMN-binding domain
PF976_02485	COG2814	Major facilitator Superfamily
PF976_02490	COG1309	transcriptional regulator
PF976_02495	COG0697	spore germination
PF976_02500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF976_02505	COG5577	PFAM Coat F domain
PF976_02515	COG1063	alcohol dehydrogenase
PF976_02520	COG5577	PFAM Coat F domain
PF976_02535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PF976_02540	COG0488	(ABC) transporter
PF976_02545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF976_02550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_02560	COG2814	Major facilitator Superfamily
PF976_02565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF976_02575	COG0730	response to heat
PF976_02580	COG0456	acetyltransferase
PF976_02585	COG4978	Transcriptional regulator
PF976_02585	COG0789	Transcriptional regulator
PF976_02590	COG0697	spore germination
PF976_02595	COG1051	belongs to the nudix hydrolase family
PF976_02600	COG0596	Alpha beta hydrolase
PF976_02605	COG0473	3-isopropylmalate dehydrogenase activity
PF976_02610	COG1802	Transcriptional regulator
PF976_02615	COG1819	glycosyl
PF976_02625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF976_02635	COG1388	LysM domain
PF976_02640	COG2814	Major facilitator Superfamily
PF976_02645	COG2188	Transcriptional regulator
PF976_02650	COG2186	Transcriptional regulator
PF976_02655	COG2807	transmembrane transport
PF976_02660	COG2076	Multidrug Resistance protein
PF976_02665	COG2076	Multidrug Resistance protein
PF976_02670	COG1309	transcriptional regulator
PF976_02675	COG0531	amino acid
PF976_02685	COG3832	glyoxalase III activity
PF976_02690	COG0604	alcohol dehydrogenase
PF976_02695	COG2814	Major facilitator Superfamily
PF976_02735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF976_02740	COG0802	atpase or kinase
PF976_02745	COG1214	PFAM Peptidase M22, glycoprotease
PF976_02750	COG0456	acetyltransferase
PF976_02755	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PF976_02760	COG0488	(ABC) transporter
PF976_02775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF976_02780	COG0805	protein transport
PF976_02790	COG1266	CAAX protease self-immunity
PF976_02810	COG2856	Zn peptidase
PF976_02825	COG1396	sequence-specific DNA binding
PF976_02865	COG5377	YqaJ viral recombinase family
PF976_02870	COG3723	Recombinational DNA repair protein, rece pathway
PF976_02875	COG3935	DnaD domain protein
PF976_02880	COG1484	DNA-dependent DNA replication
PF976_02990	COG1595	DNA-templated transcription, initiation
PF976_03015	COG5484	DNA packaging
PF976_03020	COG1783	phage Terminase large subunit
PF976_03145	COG1388	LysM domain
PF976_03145	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_03145	COG3409	Peptidoglycan-binding domain 1 protein
PF976_03155	COG3409	Peptidoglycan-binding domain 1 protein
PF976_03170	COG0457	Tetratricopeptide repeat
PF976_03175	COG1063	alcohol dehydrogenase
PF976_03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF976_03195	COG1842	Phage shock protein A
PF976_03200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF976_03205	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF976_03210	COG4260	virion core protein, lumpy skin disease virus
PF976_03215	COG2755	lipolytic protein G-D-S-L family
PF976_03215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
PF976_03225	COG1595	DNA-templated transcription, initiation
PF976_03230	COG1063	alcohol dehydrogenase
PF976_03235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF976_03240	COG0823	Involved in the tonB-independent uptake of proteins
PF976_03255	COG2132	Multicopper oxidase
PF976_03260	COG1113	amino acid transport
PF976_03265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF976_03270	COG0714	Associated with various cellular activities
PF976_03275	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PF976_03280	COG1305	Transglutaminase-like
PF976_03300	COG2252	PERMEase
PF976_03305	COG3064	Membrane
PF976_03325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PF976_03330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF976_03335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF976_03340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PF976_03345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF976_03360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PF976_03370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF976_03375	COG0138	bifunctional purine biosynthesis protein purh
PF976_03380	COG0151	Belongs to the GarS family
PF976_03385	COG1522	sequence-specific DNA binding
PF976_03390	COG0531	amino acid
PF976_03400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF976_03405	COG1470	cell adhesion involved in biofilm formation
PF976_03410	COG4496	protein, YerC YecD
PF976_03415	COG0069	glutamate synthase activity
PF976_03425	COG0210	DNA helicase
PF976_03435	COG4851	CamS sex pheromone cAM373 precursor
PF976_03440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF976_03445	COG1285	pathogenesis
PF976_03450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF976_03470	COG1309	transcriptional regulator
PF976_03475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF976_03480	COG1597	lipid kinase activity
PF976_03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF976_03500	COG1131	(ABC) transporter
PF976_03560	COG3546	catalase activity
PF976_03565	COG0454	-acetyltransferase
PF976_03575	COG2323	membrane
PF976_03580	COG2329	Antibiotic biosynthesis monooxygenase
PF976_03585	COG0346	lactoylglutathione lyase activity
PF976_03595	COG5583	Uncharacterized small protein (DUF2292)
PF976_03600	COG0196	riboflavin kinase activity
PF976_03605	COG0670	Belongs to the BI1 family
PF976_03610	COG1846	Transcriptional regulator
PF976_03615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF976_03625	COG2124	cytochrome p450
PF976_03625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF976_03630	COG1368	sulfuric ester hydrolase activity
PF976_03635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF976_03640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF976_03645	COG1442	glycosyl transferase family 8
PF976_03650	COG1216	Glycosyl transferase, family 2
PF976_03655	COG1442	glycosyl transferase family 8
PF976_03660	COG2223	nitrite transmembrane transporter activity
PF976_03665	COG0531	amino acid
PF976_03670	COG1012	belongs to the aldehyde dehydrogenase family
PF976_03680	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_03685	COG0457	Tetratricopeptide repeat
PF976_03685	COG0463	Glycosyl transferase, family 2
PF976_03690	COG0488	(ABC) transporter
PF976_03695	COG0789	Transcriptional regulator
PF976_03700	COG2814	Major facilitator Superfamily
PF976_03705	COG0488	(ABC) transporter
PF976_03710	COG0513	Belongs to the DEAD box helicase family
PF976_03715	COG2130	NADP-dependent
PF976_03730	COG3866	Pectate lyase
PF976_03735	COG0471	metal ion transport
PF976_03760	COG0745	RESPONSE REGULATOR receiver
PF976_03760	COG2972	Histidine kinase
PF976_03780	COG3764	Sortase (surface protein transpeptidase)
PF976_03785	COG3290	protein histidine kinase activity
PF976_03790	COG4565	transcriptional regulatory protein
PF976_03795	COG3181	Tripartite tricarboxylate transporter family receptor
PF976_03800	COG2851	Citrate transporter
PF976_03805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_03810	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PF976_03820	COG2258	MOSC domain
PF976_03840	COG0024	Methionine aminopeptidase
PF976_03845	COG1263	PTS System
PF976_03845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_03855	COG1368	sulfuric ester hydrolase activity
PF976_03865	COG0071	Belongs to the small heat shock protein (HSP20) family
PF976_03880	COG1263	PTS System
PF976_03880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_03885	COG0366	Alpha amylase catalytic
PF976_03890	COG2188	Transcriptional regulator
PF976_03895	COG0778	Nitroreductase
PF976_03910	COG0737	Belongs to the 5'-nucleotidase family
PF976_03915	COG0693	protein deglycase activity
PF976_03920	COG1609	Transcriptional regulator
PF976_03935	COG2814	Major facilitator Superfamily
PF976_03945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF976_03950	COG4980	gas vesicle protein
PF976_03955	COG1295	ribonuclease BN
PF976_03965	COG0477	Major facilitator Superfamily
PF976_03970	COG0387	Pfam Sodium calcium exchanger
PF976_03980	COG0668	transmembrane transport
PF976_03985	COG0535	radical SAM domain protein
PF976_03995	COG0726	polysaccharide deacetylase
PF976_04000	COG2084	Dehydrogenase
PF976_04010	COG0598	Magnesium transport protein CorA
PF976_04015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF976_04020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF976_04030	COG1132	(ABC) transporter
PF976_04035	COG0515	serine threonine protein kinase
PF976_04075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF976_04080	COG4637	Psort location Cytoplasmic, score
PF976_04085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF976_04090	COG0022	dehydrogenase e1 component
PF976_04095	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF976_04100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF976_04105	COG3284	Transcriptional regulator
PF976_04115	COG1486	melibiose metabolic process
PF976_04120	COG1737	Transcriptional regulator
PF976_04125	COG1263	PTS System
PF976_04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_04130	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_04135	COG1132	(ABC) transporter
PF976_04140	COG1132	(ABC) transporter
PF976_04145	COG2259	Doxx family
PF976_04150	COG2514	catechol 2,3-dioxygenase activity
PF976_04160	COG1695	Transcriptional regulator
PF976_04165	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF976_04170	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
PF976_04175	COG2732	(Barnase) inhibitor
PF976_04180	COG2318	DinB family
PF976_04185	COG2814	Major facilitator Superfamily
PF976_04190	COG1846	Transcriptional regulator
PF976_04195	COG0392	lysyltransferase activity
PF976_04195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PF976_04200	COG0384	phenazine biosynthesis protein PhzF
PF976_04205	COG0778	Nitroreductase
PF976_04220	COG1090	epimerase
PF976_04235	COG2814	Major facilitator Superfamily
PF976_04245	COG3591	Belongs to the peptidase S1B family
PF976_04260	COG3103	Sh3 type 3 domain protein
PF976_04265	COG5658	integral membrane protein
PF976_04275	COG0463	Glycosyl transferase, family 2
PF976_04280	COG4485	Bacterial membrane protein, YfhO
PF976_04285	COG1988	membrane-bound metal-dependent
PF976_04290	COG1194	a g-specific adenine glycosylase
PF976_04300	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_04320	COG1132	(ABC) transporter
PF976_04325	COG4129	membrane
PF976_04335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF976_04340	COG0735	belongs to the Fur family
PF976_04455	COG1757	Na H antiporter
PF976_04460	COG3340	Belongs to the peptidase S51 family
PF976_04470	COG0277	FAD linked oxidase domain protein
PF976_04480	COG0747	negative chemotaxis
PF976_04485	COG0601	transmembrane transport
PF976_04490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF976_04495	COG0444	Belongs to the ABC transporter superfamily
PF976_04505	COG0753	catalase activity
PF976_04515	COG1116	anion transmembrane transporter activity
PF976_04520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF976_04525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF976_04550	COG1476	TRANSCRIPTIONal
PF976_04560	COG3382	B3 4 domain protein
PF976_04565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF976_04575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF976_04580	COG0789	Transcriptional regulator
PF976_04585	COG1664	Polymer-forming cytoskeletal
PF976_04590	COG1664	Polymer-forming cytoskeletal
PF976_04595	COG2766	serine protein kinase
PF976_04605	COG1846	Transcriptional regulator
PF976_04610	COG1566	PFAM secretion protein HlyD family protein
PF976_04615	COG2814	Major facilitator Superfamily
PF976_04620	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF976_04635	COG1725	Transcriptional regulator
PF976_04640	COG1131	(ABC) transporter
PF976_04645	COG1131	(ABC) transporter
PF976_04650	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF976_04655	COG1278	Cold shock
PF976_04660	COG1464	Belongs to the NlpA lipoprotein family
PF976_04665	COG3706	GGDEF domain
PF976_04670	COG1823	symporter activity
PF976_04675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF976_04695	COG5577	PFAM Coat F domain
PF976_04700	COG4085	toxin activity
PF976_04700	COG0737	Belongs to the 5'-nucleotidase family
PF976_04700	COG1525	nuclease
PF976_04705	COG3764	Sortase (surface protein transpeptidase)
PF976_04710	COG0564	pseudouridine synthase activity
PF976_04720	COG0517	IMP dehydrogenase activity
PF976_04725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF976_04730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF976_04730	COG3153	acetyltransferase
PF976_04735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF976_04740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PF976_04745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF976_04755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PF976_04760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF976_04770	COG2197	response regulator
PF976_04775	COG0431	NADPH-dependent FMN reductase
PF976_04790	COG1388	LysM domain
PF976_04790	COG0791	NLP P60 protein
PF976_04795	COG1959	2 iron, 2 sulfur cluster binding
PF976_04805	COG2719	SpoVR family
PF976_04810	COG1785	Belongs to the alkaline phosphatase family
PF976_04815	COG0791	NLP P60 protein
PF976_04815	COG1388	LysM domain
PF976_04820	COG0583	DNA-binding transcription factor activity
PF976_04825	COG0372	Belongs to the citrate synthase family
PF976_04830	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_04835	COG0531	amino acid
PF976_04840	COG0733	neurotransmitter:sodium symporter activity
PF976_04855	COG1595	DNA-templated transcription, initiation
PF976_04860	COG0204	Acyl-transferase
PF976_04865	COG1253	flavin adenine dinucleotide binding
PF976_04870	COG0789	Transcriptional regulator
PF976_04875	COG0436	Aminotransferase
PF976_04880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF976_04885	COG1253	flavin adenine dinucleotide binding
PF976_04890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF976_04895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF976_04900	COG0584	glycerophosphoryl diester phosphodiesterase
PF976_04910	COG0668	transmembrane transport
PF976_04915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF976_04920	COG0726	polysaccharide deacetylase
PF976_04925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF976_04930	COG3226	Transcriptional regulator
PF976_04940	COG0589	response to stress
PF976_04945	COG1132	(ABC) transporter
PF976_04950	COG1132	(ABC) transporter
PF976_04955	COG0702	epimerase
PF976_04975	COG0189	ligase activity
PF976_04980	COG0189	ligase activity
PF976_04995	COG0561	phosphatase activity
PF976_05000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF976_05010	COG0475	glutathione-regulated potassium exporter activity
PF976_05015	COG0490	domain, Protein
PF976_05025	COG1024	Enoyl-CoA hydratase
PF976_05035	COG4152	abc transporter atp-binding protein
PF976_05040	COG1668	transmembrane transport
PF976_05045	COG0420	3'-5' exonuclease activity
PF976_05050	COG4717	serine-type aminopeptidase activity
PF976_05065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF976_05100	COG4980	gas vesicle protein
PF976_05115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PF976_05120	COG0537	adenosine 5'-monophosphoramidase activity
PF976_05125	COG1131	(ABC) transporter
PF976_05130	COG4473	ABC transporter
PF976_05140	COG1473	amidohydrolase
PF976_05145	COG3069	C4-dicarboxylate transmembrane transporter activity
PF976_05150	COG2329	Antibiotic biosynthesis monooxygenase
PF976_05155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF976_05165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PF976_05170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PF976_05175	COG1309	transcriptional regulator
PF976_05180	COG1511	domain protein
PF976_05185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF976_05195	COG1363	Peptidase, m42
PF976_05200	COG1301	dicarboxylic acid transport
PF976_05210	COG1234	tRNA 3'-trailer cleavage
PF976_05215	COG0095	Lipoate-protein ligase
PF976_05220	COG0702	epimerase
PF976_05225	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_05235	COG0501	Belongs to the peptidase M48B family
PF976_05240	COG1404	Belongs to the peptidase S8 family
PF976_05245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF976_05250	COG0406	alpha-ribazole phosphatase activity
PF976_05255	COG0183	Belongs to the thiolase family
PF976_05260	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_05265	COG1268	BioY protein
PF976_05270	COG0840	transmembrane signaling receptor activity
PF976_05280	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_05290	COG4903	ComK protein
PF976_05295	COG5646	InterPro IPR014922
PF976_05320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF976_05335	COG0398	Pfam SNARE associated Golgi protein
PF976_05340	COG0681	Belongs to the peptidase S26 family
PF976_05345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF976_05350	COG1846	Transcriptional regulator
PF976_05355	COG3180	Ammonia monooxygenase
PF976_05360	COG2814	Major facilitator Superfamily
PF976_05370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PF976_05375	COG2323	membrane
PF976_05390	COG0420	3'-5' exonuclease activity
PF976_05395	COG0419	ATPase involved in DNA repair
PF976_05400	COG1403	HNH endonuclease
PF976_05440	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF976_05450	COG1404	Belongs to the peptidase S8 family
PF976_05460	COG0367	asparagine synthase
PF976_05465	COG1562	ergosterol biosynthetic process
PF976_05470	COG0534	Mate efflux family protein
PF976_05475	COG2207	Transcriptional regulator
PF976_05475	COG1917	Cupin 2, conserved barrel domain protein
PF976_05480	COG1609	Transcriptional regulator
PF976_05485	COG0673	inositol 2-dehydrogenase activity
PF976_05490	COG2318	DinB family
PF976_05495	COG1279	arginine transmembrane transporter activity
PF976_05500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF976_05505	COG1357	PFAM Pentapeptide repeats (8 copies)
PF976_05510	COG2153	protein acetylation
PF976_05515	COG0646	methionine synthase
PF976_05515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF976_05525	COG2996	Protein conserved in bacteria
PF976_05530	COG1744	ABC transporter substrate-binding protein PnrA-like
PF976_05535	COG0840	transmembrane signaling receptor activity
PF976_05540	COG2124	cytochrome p450
PF976_05550	COG1307	EDD domain protein, DegV family
PF976_05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_05575	COG0561	phosphatase activity
PF976_05580	COG1073	alpha beta
PF976_05585	COG2151	metal-sulfur cluster biosynthetic enzyme
PF976_05595	COG0277	FAD linked oxidase domain protein
PF976_05600	COG2271	Major facilitator Superfamily
PF976_05610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF976_05620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF976_05625	COG0505	Belongs to the CarA family
PF976_05630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF976_05635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PF976_05650	COG2267	carboxylic ester hydrolase activity
PF976_05660	COG1744	ABC transporter substrate-binding protein PnrA-like
PF976_05675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF976_05680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF976_05685	COG5504	Zn-dependent protease
PF976_05690	COG0444	Belongs to the ABC transporter superfamily
PF976_05695	COG4608	Belongs to the ABC transporter superfamily
PF976_05705	COG0601	transmembrane transport
PF976_05710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF976_05720	COG0180	Tryptophanyl-tRNA synthetase
PF976_05725	COG4166	transmembrane transport
PF976_05730	COG0601	transmembrane transport
PF976_05735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF976_05740	COG0444	Belongs to the ABC transporter superfamily
PF976_05745	COG4608	Belongs to the ABC transporter superfamily
PF976_05755	COG0456	acetyltransferase
PF976_05760	COG1393	Belongs to the ArsC family
PF976_05765	COG0861	Integral membrane protein TerC family
PF976_05775	COG4862	establishment of competence for transformation
PF976_05780	COG4469	Competence protein
PF976_05785	COG1164	Oligoendopeptidase f
PF976_05795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF976_05800	COG2346	COG2346, Truncated hemoglobins
PF976_05805	COG0741	lytic transglycosylase activity
PF976_05810	COG4116	CYTH
PF976_05820	COG2357	RelA SpoT domain protein
PF976_05825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF976_05830	COG0564	pseudouridine synthase activity
PF976_05840	COG0475	glutathione-regulated potassium exporter activity
PF976_05840	COG0569	domain protein
PF976_05845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF976_05850	COG0352	thiamine-phosphate diphosphorylase activity
PF976_05855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF976_05860	COG2104	thiamine diphosphate biosynthetic process
PF976_05870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF976_05875	COG0351	phosphomethylpyrimidine kinase
PF976_05880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PF976_05935	COG0210	DNA helicase
PF976_05945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_05955	COG1131	(ABC) transporter
PF976_05965	COG2153	protein acetylation
PF976_05975	COG2382	esterase
PF976_05980	COG0626	cystathionine gamma-synthase activity
PF976_05985	COG0626	cystathionine gamma-synthase activity
PF976_06010	COG4282	regulation of fungal-type cell wall biogenesis
PF976_06100	COG2367	Beta-lactamase
PF976_06105	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF976_06110	COG0477	Major facilitator Superfamily
PF976_06115	COG1846	Transcriptional regulator
PF976_06125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_06125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_06130	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF976_06135	COG2723	6-phospho-beta-galactosidase activity
PF976_06140	COG1349	DNA-binding transcription factor activity
PF976_06160	COG1285	pathogenesis
PF976_06170	COG2205	protein histidine kinase activity
PF976_06180	COG3383	formate dehydrogenase (NAD+) activity
PF976_06185	COG2427	Protein of unknown function (DUF1641)
PF976_06190	COG2124	cytochrome p450
PF976_06195	COG1819	glycosyl
PF976_06205	COG1587	Uroporphyrinogen-III synthase
PF976_06210	COG0390	transport system, permease component
PF976_06215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF976_06220	COG0697	spore germination
PF976_06225	COG4297	protein containing double-stranded beta helix domain
PF976_06235	COG1252	NADH dehydrogenase
PF976_06245	COG1609	Transcriptional regulator
PF976_06260	COG0745	RESPONSE REGULATOR receiver
PF976_06265	COG2205	protein histidine kinase activity
PF976_06265	COG2770	Histidine kinase
PF976_06280	COG0730	response to heat
PF976_06285	COG2318	DinB family
PF976_06290	COG0457	Tetratricopeptide repeat
PF976_06300	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_06300	COG3409	Peptidoglycan-binding domain 1 protein
PF976_06300	COG1388	LysM domain
PF976_06310	COG4195	phage-related replication protein
PF976_06315	COG2856	Zn peptidase
PF976_06320	COG1396	sequence-specific DNA binding
PF976_06330	COG1522	sequence-specific DNA binding
PF976_06335	COG1484	DNA-dependent DNA replication
PF976_06355	COG1595	DNA-templated transcription, initiation
PF976_06360	COG5484	DNA packaging
PF976_06360	COG3728	DNA packaging
PF976_06365	COG1783	phage Terminase large subunit
PF976_06370	COG5518	Phage portal protein
PF976_06375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PF976_06380	COG4653	Phage capsid family
PF976_06430	COG3953	SLT domain
PF976_06430	COG3953	SLT domain
PF976_06430	COG5412	phage tail tape measure protein
PF976_06430	COG5412	phage tail tape measure protein
PF976_06430	COG3953	SLT domain
PF976_06430	COG5412	phage tail tape measure protein
PF976_06435	COG1652	LysM domain
PF976_06440	COG4193	domain, Protein
PF976_06450	COG3628	GPW Gp25 family protein
PF976_06455	COG3299	homolog of phage Mu protein gp47
PF976_06460	COG3778	Protein conserved in bacteria
PF976_06500	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_06500	COG3409	Peptidoglycan-binding domain 1 protein
PF976_06520	COG0306	phosphate transporter
PF976_06525	COG1392	Phosphate transport regulator
PF976_06530	COG0531	amino acid
PF976_06535	COG0346	lactoylglutathione lyase activity
PF976_06540	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF976_06545	COG0463	Glycosyl transferase, family 2
PF976_06555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF976_06560	COG0477	Major facilitator Superfamily
PF976_06565	COG2362	D-Aminopeptidase
PF976_06570	COG0601	transmembrane transport
PF976_06575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF976_06580	COG0444	Belongs to the ABC transporter superfamily
PF976_06585	COG4166	transmembrane transport
PF976_06590	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF976_06595	COG4948	Mandelate Racemase Muconate Lactonizing
PF976_06600	COG0791	NLP P60 protein
PF976_06605	COG4608	Belongs to the ABC transporter superfamily
PF976_06610	COG2706	6-phosphogluconolactonase activity
PF976_06620	COG1607	acyl-coa hydrolase
PF976_06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF976_06630	COG2076	Multidrug Resistance protein
PF976_06635	COG2076	Multidrug Resistance protein
PF976_06640	COG0788	formyltetrahydrofolate deformylase activity
PF976_06645	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF976_06655	COG1764	response to oxidative stress
PF976_06660	COG1846	Transcriptional regulator
PF976_06665	COG1764	response to oxidative stress
PF976_06680	COG0457	Tetratricopeptide repeat
PF976_06680	COG0463	Glycosyl transferase, family 2
PF976_06695	COG2814	Major facilitator Superfamily
PF976_06700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF976_06710	COG1404	Belongs to the peptidase S8 family
PF976_06715	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_06720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF976_06725	COG1122	ATPase activity
PF976_06730	COG4721	ABC-type cobalt transport system, permease component
PF976_06735	COG3858	chitin binding
PF976_06735	COG1388	LysM domain
PF976_06745	COG2239	Acts as a magnesium transporter
PF976_06750	COG0789	Transcriptional regulator
PF976_06765	COG1846	Transcriptional regulator
PF976_06770	COG0726	polysaccharide deacetylase
PF976_06775	COG1793	dna ligase
PF976_06775	COG3285	dna ligase
PF976_06780	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PF976_06785	COG5001	Diguanylate cyclase
PF976_06785	COG3300	MHYT domain
PF976_06790	COG0586	Pfam SNARE associated Golgi protein
PF976_06800	COG1191	sigma factor activity
PF976_06825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF976_06830	COG2323	membrane
PF976_06840	COG3594	Acyltransferase
PF976_06845	COG5002	protein histidine kinase activity
PF976_06850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF976_06870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF976_06875	COG0436	Aminotransferase
PF976_06905	COG3852	Histidine kinase
PF976_06910	COG1846	Transcriptional regulator
PF976_06915	COG1360	Flagellar Motor Protein
PF976_06920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF976_06925	COG0542	response to heat
PF976_06930	COG3949	Membrane
PF976_06950	COG0720	synthase
PF976_06955	COG0602	queuosine metabolic process
PF976_06970	COG4873	Protein conserved in bacteria
PF976_06980	COG3773	Cell wall hydrolase
PF976_06985	COG2244	polysaccharide biosynthetic process
PF976_06990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_06995	COG2217	Heavy metal translocating P-type atpase
PF976_07000	COG0006	proline dipeptidase activity
PF976_07015	COG3711	transcriptional antiterminator
PF976_07020	COG2190	(PTS) system
PF976_07020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_07020	COG1263	PTS System
PF976_07025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_07030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF976_07040	COG1533	DNA photolyase activity
PF976_07045	COG0840	transmembrane signaling receptor activity
PF976_07050	COG2084	Dehydrogenase
PF976_07060	COG2340	Cysteine-rich secretory protein family
PF976_07065	COG0768	penicillin binding
PF976_07070	COG4191	Histidine kinase
PF976_07075	COG0436	Aminotransferase
PF976_07085	COG0784	Response regulator, receiver
PF976_07085	COG0835	chemotaxis
PF976_07095	COG2814	Major facilitator Superfamily
PF976_07100	COG1376	ErfK ybiS ycfS ynhG family protein
PF976_07105	COG1408	metallophosphoesterase
PF976_07110	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_07120	COG2200	EAL domain
PF976_07125	COG4703	Protein of unknown function (DUF1797)
PF976_07130	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
PF976_07140	COG0517	IMP dehydrogenase activity
PF976_07145	COG0583	DNA-binding transcription factor activity
PF976_07150	COG0716	FMN binding
PF976_07160	COG0716	FMN binding
PF976_07180	COG0668	transmembrane transport
PF976_07185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_07205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF976_07210	COG0303	'Molybdopterin
PF976_07215	COG1763	Mo-molybdopterin cofactor biosynthetic process
PF976_07220	COG0314	molybdopterin synthase activity
PF976_07225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PF976_07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF976_07240	COG1136	(ABC) transporter
PF976_07245	COG0577	efflux transmembrane transporter activity
PF976_07250	COG1349	DNA-binding transcription factor activity
PF976_07255	COG1105	Belongs to the carbohydrate kinase PfkB family
PF976_07260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF976_07260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF976_07260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_07265	COG0681	Belongs to the peptidase S26 family
PF976_07275	COG0488	(ABC) transporter
PF976_07280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF976_07285	COG2309	aminopeptidase activity
PF976_07295	COG1077	Cell shape determining protein MreB Mrl
PF976_07300	COG2002	toxin-antitoxin pair type II binding
PF976_07305	COG3852	Histidine kinase
PF976_07310	COG2105	PFAM AIG2 family protein
PF976_07310	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
PF976_07315	COG0569	domain protein
PF976_07325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF976_07335	COG0561	phosphatase activity
PF976_07340	COG0242	peptide deformylase activity
PF976_07350	COG0497	DNA recombination
PF976_07355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF976_07360	COG0022	dehydrogenase e1 component
PF976_07365	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF976_07370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF976_07375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_07390	COG1982	Orn Lys Arg decarboxylase major
PF976_07410	COG0483	inositol monophosphate 1-phosphatase activity
PF976_07420	COG3227	Zinc metalloprotease (Elastase)
PF976_07445	COG1217	gtp-binding protein TYPA
PF976_07455	COG4896	Protein conserved in bacteria
PF976_07465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PF976_07470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF976_07475	COG2066	Belongs to the glutaminase family
PF976_07485	COG0772	Belongs to the SEDS family
PF976_07490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PF976_07505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF976_07505	COG2010	Cytochrome c
PF976_07510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF976_07515	COG1845	cytochrome c oxidase, subunit III
PF976_07520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF976_07525	COG3336	cytochrome c oxidase
PF976_07535	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PF976_07540	COG2340	Cysteine-rich secretory protein family
PF976_07555	COG3679	Belongs to the UPF0342 family
PF976_07565	COG0742	ribosomal rna small subunit methyltransferase
PF976_07575	COG3314	Sporulation integral membrane protein YlbJ
PF976_07580	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF976_07585	COG3480	Lon protease (S16) C-terminal proteolytic domain
PF976_07595	COG1399	metal-binding, possibly nucleic acid-binding protein
PF976_07615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF976_07635	COG4839	cell division protein FtsL
PF976_07640	COG0768	penicillin binding
PF976_07645	COG0768	penicillin binding
PF976_07665	COG0772	Belongs to the SEDS family
PF976_07680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF976_07685	COG0849	cell division
PF976_07690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF976_07695	COG1404	Belongs to the peptidase S8 family
PF976_07695	COG4412	M6 family metalloprotease domain protein
PF976_07705	COG1191	sigma factor activity
PF976_07710	COG1191	sigma factor activity
PF976_07715	COG1119	ATPase activity
PF976_07720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF976_07725	COG1873	PFAM PRC-barrel domain
PF976_07730	COG1496	oxidoreductase activity
PF976_07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PF976_07745	COG0762	integral membrane protein
PF976_07750	COG2302	S4 RNA-binding domain
PF976_07755	COG3599	regulation of cell shape
PF976_07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF976_07765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF976_07775	COG0564	pseudouridine synthase activity
PF976_07785	COG2233	PERMEase
PF976_07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF976_07800	COG0505	Belongs to the CarA family
PF976_07805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF976_07820	COG0284	orotidine-5'-phosphate decarboxylase activity
PF976_07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PF976_07835	COG0306	phosphate transporter
PF976_07850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF976_07855	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
PF976_07860	COG1648	precorrin-2 dehydrogenase activity
PF976_07875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF976_07880	COG1561	YicC-like family, N-terminal region
PF976_07890	COG0194	GDP metabolic process
PF976_07900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF976_07905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF976_07910	COG0242	peptide deformylase activity
PF976_07920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PF976_07920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF976_07930	COG0631	protein serine/threonine phosphatase activity
PF976_07935	COG0515	serine threonine protein kinase
PF976_07935	COG2815	serine threonine protein kinase
PF976_07945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF976_07950	COG1564	THIamine pyrophosphokinase
PF976_07965	COG1302	Protein conserved in bacteria
PF976_07970	COG1461	Dihydroxyacetone kinase
PF976_07975	COG1760	l-serine dehydratase
PF976_07980	COG1760	l-serine dehydratase
PF976_07985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF976_08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF976_08005	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_08020	COG1196	nuclear chromosome segregation
PF976_08025	COG0552	protein localization to endoplasmic reticulum
PF976_08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF976_08045	COG1837	Belongs to the UPF0109 family
PF976_08070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF976_08085	COG2257	FlhB HrpN YscU SpaS Family
PF976_08095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PF976_08100	COG0758	DNA mediated transformation
PF976_08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF976_08115	COG4974	Belongs to the 'phage' integrase family
PF976_08135	COG1815	bacterial-type flagellum-dependent cell motility
PF976_08140	COG1558	bacterial-type flagellum-dependent cell motility
PF976_08145	COG1677	Flagellar hook-basal body complex protein FliE
PF976_08150	COG1766	The M ring may be actively involved in energy transduction
PF976_08155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF976_08160	COG1317	bacterial-type flagellum organization
PF976_08165	COG1157	protein secretion by the type III secretion system
PF976_08170	COG2882	bacterial-type flagellum organization
PF976_08175	COG3334	PFAM MgtE intracellular
PF976_08180	COG3144	bacterial-type flagellum assembly
PF976_08185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PF976_08190	COG4786	Flagellar basal body rod
PF976_08195	COG1582	Flagellar protein (FlbD)
PF976_08200	COG1580	Controls the rotational direction of flagella during chemotaxis
PF976_08205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF976_08210	COG1776	CheC inhibitor of MCP methylation
PF976_08210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF976_08215	COG2201	protein-glutamate methylesterase activity
PF976_08220	COG3190	flagellar
PF976_08225	COG1338	Plays a role in the flagellum-specific transport system
PF976_08230	COG1987	bacterial-type flagellum assembly
PF976_08235	COG1684	flagellar biosynthetic protein fliR
PF976_08240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF976_08245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF976_08250	COG1419	protein localization to endoplasmic reticulum
PF976_08255	COG0455	bacterial-type flagellum organization
PF976_08260	COG2201	protein-glutamate methylesterase activity
PF976_08265	COG0643	Histidine kinase
PF976_08265	COG2198	Histidine kinase
PF976_08270	COG0835	chemotaxis
PF976_08275	COG1776	CheC inhibitor of MCP methylation
PF976_08285	COG1191	sigma factor activity
PF976_08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF976_08320	COG4589	Belongs to the CDS family
PF976_08330	COG0750	zinc metalloprotease
PF976_08350	COG0195	Participates in both transcription termination and antitermination
PF976_08355	COG2740	Nucleic-acid-binding protein implicated in transcription termination
PF976_08360	COG1358	cellular component organization or biogenesis
PF976_08370	COG1550	Protein conserved in bacteria
PF976_08385	COG0196	riboflavin kinase activity
PF976_08400	COG0726	polysaccharide deacetylase
PF976_08405	COG0612	Peptidase, M16
PF976_08410	COG1873	PFAM PRC-barrel domain
PF976_08415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF976_08425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF976_08430	COG1525	nuclease
PF976_08435	COG4282	regulation of fungal-type cell wall biogenesis
PF976_08445	COG5444	nuclease activity
PF976_08475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF976_08485	COG0457	Tetratricopeptide repeat
PF976_08505	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_08505	COG3409	Peptidoglycan-binding domain 1 protein
PF976_08510	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_08550	COG0515	serine threonine protein kinase
PF976_08550	COG2815	serine threonine protein kinase
PF976_08685	COG0776	regulation of translation
PF976_08775	COG3655	Transcriptional regulator
PF976_08900	COG3655	Transcriptional regulator
PF976_08970	COG4474	Belongs to the UPF0398 family
PF976_09000	COG0756	dUTP diphosphatase activity
PF976_09015	COG1793	dna ligase
PF976_09020	COG2135	peptidase activity
PF976_09045	COG4195	phage-related replication protein
PF976_09050	COG3420	alginic acid biosynthetic process
PF976_09050	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_09070	COG2404	hydrolase activity, acting on ester bonds
PF976_09110	COG3584	3D domain protein
PF976_09125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF976_09130	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
PF976_09145	COG0270	DNA (cytosine-5-)-methyltransferase activity
PF976_09190	COG1780	Probably involved in ribonucleotide reductase function
PF976_09235	COG0756	dUTP diphosphatase activity
PF976_09255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF976_09260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF976_09290	COG3331	DNA recombination
PF976_09305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PF976_09310	COG0527	aspartate kinase activity
PF976_09320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF976_09325	COG0740	serine-type endopeptidase activity
PF976_09335	COG4980	gas vesicle protein
PF976_09335	COG1674	ftsk spoiiie
PF976_09340	COG2188	Transcriptional regulator
PF976_09345	COG2814	Major facilitator Superfamily
PF976_09350	COG1846	Transcriptional regulator
PF976_09355	COG1033	growth of symbiont in host cell
PF976_09355	COG2409	Drug exporters of the RND superfamily
PF976_09360	COG0612	Peptidase, M16
PF976_09365	COG0612	Peptidase, M16
PF976_09370	COG0300	oxidoreductase activity
PF976_09385	COG1426	Protein conserved in bacteria
PF976_09390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF976_09405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF976_09415	COG1692	metallophosphoesterase
PF976_09420	COG2359	stage V sporulation protein S
PF976_09440	COG4550	Control of competence regulator ComK, YlbF/YmcA
PF976_09480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF976_09485	COG3425	synthase
PF976_09490	COG1024	Enoyl-CoA hydratase
PF976_09495	COG1024	Enoyl-CoA hydratase
PF976_09500	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_09500	COG3321	synthase
PF976_09500	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_09500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_09500	COG0300	oxidoreductase activity
PF976_09505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF976_09505	COG0300	oxidoreductase activity
PF976_09505	COG3321	synthase
PF976_09505	COG4221	oxidoreductase activity
PF976_09510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF976_09510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF976_09510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF976_09510	COG3321	synthase
PF976_09510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_09510	COG3321	synthase
PF976_09510	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_09510	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF976_09515	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_09515	COG3321	synthase
PF976_09515	COG4221	oxidoreductase activity
PF976_09515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_09520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF976_09520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF976_09520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF976_09520	COG3321	synthase
PF976_09525	COG2124	cytochrome p450
PF976_09530	COG3209	COG3209 Rhs family protein
PF976_09535	COG3619	membrane
PF976_09545	COG1404	Belongs to the peptidase S8 family
PF976_09555	COG4195	phage-related replication protein
PF976_09560	COG1764	response to oxidative stress
PF976_09570	COG2076	Multidrug Resistance protein
PF976_09610	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF976_09615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF976_09620	COG4112	unkown
PF976_09630	COG0464	growth
PF976_09635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF976_09640	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PF976_09645	COG0789	Transcriptional regulator
PF976_09650	COG0174	glutamine synthetase
PF976_09655	COG4974	Belongs to the 'phage' integrase family
PF976_09675	COG3645	SOS response
PF976_09675	COG3646	Phage regulatory protein
PF976_09715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF976_09715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF976_09820	COG3953	SLT domain
PF976_09820	COG5412	phage tail tape measure protein
PF976_09830	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF976_09835	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_09855	COG4824	toxin secretion phage lysis holin
PF976_09860	COG3409	Peptidoglycan-binding domain 1 protein
PF976_09860	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_09860	COG1388	LysM domain
PF976_09880	COG0726	polysaccharide deacetylase
PF976_09885	COG2124	cytochrome p450
PF976_09890	COG2211	Major facilitator Superfamily
PF976_09895	COG3507	Belongs to the glycosyl hydrolase 43 family
PF976_09910	COG1070	Carbohydrate kinase
PF976_09930	COG3397	chitin binding
PF976_09950	COG5434	Belongs to the glycosyl hydrolase 28 family
PF976_09955	COG2314	TM2 domain
PF976_09960	COG0756	dUTP diphosphatase activity
PF976_09970	COG4195	phage-related replication protein
PF976_10005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF976_10015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF976_10035	COG0785	Cytochrome C biogenesis protein
PF976_10040	COG2201	protein-glutamate methylesterase activity
PF976_10045	COG4846	Membrane protein involved in cytochrome C biogenesis
PF976_10055	COG0071	Belongs to the small heat shock protein (HSP20) family
PF976_10070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF976_10075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_10095	COG0824	Thioesterase
PF976_10105	COG4841	protein insertion into membrane
PF976_10115	COG1832	CoA-binding protein
PF976_10120	COG0187	DNA topoisomerase II activity
PF976_10125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF976_10140	COG1115	amino acid carrier protein
PF976_10165	COG2205	protein histidine kinase activity
PF976_10170	COG0745	RESPONSE REGULATOR receiver
PF976_10180	COG3507	Belongs to the glycosyl hydrolase 43 family
PF976_10210	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_10215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF976_10220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF976_10225	COG2124	cytochrome p450
PF976_10245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF976_10255	COG2246	polysaccharide biosynthetic process
PF976_10260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF976_10265	COG0586	Pfam SNARE associated Golgi protein
PF976_10270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF976_10275	COG1024	Enoyl-CoA hydratase
PF976_10280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF976_10285	COG0511	ligase activity, forming carbon-carbon bonds
PF976_10290	COG0439	Biotin carboxylase
PF976_10295	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_10300	COG1960	acyl-CoA dehydrogenase activity
PF976_10305	COG1649	PFAM Uncharacterised BCR, COG1649
PF976_10315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_10315	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF976_10325	COG2027	D-alanyl-D-alanine carboxypeptidase
PF976_10330	COG2017	converts alpha-aldose to the beta-anomer
PF976_10335	COG0534	Mate efflux family protein
PF976_10350	COG0582	viral genome integration into host DNA
PF976_10355	COG0166	Belongs to the GPI family
PF976_10360	COG0405	Gamma-glutamyltransferase
PF976_10365	COG2814	Major facilitator Superfamily
PF976_10370	COG0640	Transcriptional regulator
PF976_10380	COG0493	'glutamate synthase
PF976_10385	COG0067	glutamate synthase
PF976_10385	COG0069	glutamate synthase activity
PF976_10385	COG0070	glutamate synthase
PF976_10390	COG0583	DNA-binding transcription factor activity
PF976_10395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF976_10410	COG0300	oxidoreductase activity
PF976_10415	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF976_10430	COG2323	membrane
PF976_10435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF976_10445	COG2323	membrane
PF976_10460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF976_10505	COG1070	Carbohydrate kinase
PF976_10510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF976_10515	COG0243	molybdopterin cofactor binding
PF976_10540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF976_10545	COG0662	Cupin 2, conserved barrel domain protein
PF976_10545	COG2207	Transcriptional regulator
PF976_10550	COG1309	transcriptional regulator
PF976_10555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_10565	COG0640	Transcriptional regulator
PF976_10570	COG0741	lytic transglycosylase activity
PF976_10575	COG2322	membrane
PF976_10590	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF976_10600	COG1388	LysM domain
PF976_10600	COG3584	3D domain protein
PF976_10605	COG0514	ATP-dependent DNA helicase (RecQ)
PF976_10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF976_10620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF976_10635	COG0071	Belongs to the small heat shock protein (HSP20) family
PF976_10660	COG1012	belongs to the aldehyde dehydrogenase family
PF976_10665	COG1657	PFAM Prenyltransferase squalene oxidase
PF976_10670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF976_10675	COG0733	neurotransmitter:sodium symporter activity
PF976_10680	COG0385	Bile acid
PF976_10685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_10690	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF976_10700	COG4548	von Willebrand factor, type A
PF976_10705	COG0714	Associated with various cellular activities
PF976_10710	COG2032	superoxide dismutase activity
PF976_10715	COG0791	NLP P60 protein
PF976_10715	COG1388	LysM domain
PF976_10720	COG1819	glycosyl
PF976_10725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF976_10730	COG0534	Mate efflux family protein
PF976_10735	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_10740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF976_10745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF976_10755	COG2962	Rard protein
PF976_10770	COG1942	4-Oxalocrotonate Tautomerase
PF976_10775	COG1733	regulation of RNA biosynthetic process
PF976_10780	COG0778	Nitroreductase
PF976_10785	COG0400	carboxylic ester hydrolase activity
PF976_10790	COG0346	lactoylglutathione lyase activity
PF976_10810	COG2723	6-phospho-beta-galactosidase activity
PF976_10815	COG2188	Transcriptional regulator
PF976_10820	COG0793	Belongs to the peptidase S41A family
PF976_10820	COG3409	Peptidoglycan-binding domain 1 protein
PF976_10825	COG2226	methyltransferase
PF976_10835	COG1876	peptidase activity
PF976_10855	COG0671	phosphoesterase, PA-phosphatase related
PF976_10875	COG0346	lactoylglutathione lyase activity
PF976_10890	COG1509	lysine 2,3-aminomutase activity
PF976_10895	COG0456	acetyltransferase
PF976_10900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF976_10905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF976_10910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF976_10915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF976_10920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
PF976_10930	COG0456	acetyltransferase
PF976_10935	COG0463	Glycosyl transferase, family 2
PF976_10950	COG4641	Protein conserved in bacteria
PF976_10960	COG1086	Polysaccharide biosynthesis protein
PF976_10985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF976_11005	COG1846	Transcriptional regulator
PF976_11010	COG4698	Protein conserved in bacteria
PF976_11015	COG2755	lipolytic protein G-D-S-L family
PF976_11020	COG1999	signal sequence binding
PF976_11030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF976_11035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF976_11040	COG1272	protein, Hemolysin III
PF976_11045	COG0204	Acyl-transferase
PF976_11050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF976_11055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF976_11065	COG2136	Putative SAM-dependent methyltransferase
PF976_11065	COG2521	methyltransferase
PF976_11080	COG1413	lyase activity
PF976_11085	COG1418	mRNA catabolic process
PF976_11090	COG0386	Belongs to the glutathione peroxidase family
PF976_11100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF976_11110	COG1278	Cold shock
PF976_11130	COG0328	RNA-DNA hybrid ribonuclease activity
PF976_11135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PF976_11140	COG0328	RNA-DNA hybrid ribonuclease activity
PF976_11150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF976_11165	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF976_11170	COG1755	Isoprenylcysteine carboxyl methyltransferase
PF976_11175	COG3424	synthase
PF976_11195	COG2233	PERMEase
PF976_11205	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PF976_11210	COG1199	ATP-dependent helicase activity
PF976_11230	COG0116	Belongs to the methyltransferase superfamily
PF976_11260	COG3359	exonuclease
PF976_11265	COG1205	dead DEAH box helicase
PF976_11265	COG1111	helicase
PF976_11270	COG2190	(PTS) system
PF976_11275	COG0071	Belongs to the small heat shock protein (HSP20) family
PF976_11315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF976_11315	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF976_11325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF976_11330	COG3935	DnaD domain protein
PF976_11340	COG0436	Aminotransferase
PF976_11345	COG5353	protein conserved in bacteria
PF976_11355	COG1199	ATP-dependent helicase activity
PF976_11355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF976_11385	COG0438	transferase activity, transferring glycosyl groups
PF976_11390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF976_11405	COG1694	Mazg nucleotide pyrophosphohydrolase
PF976_11410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_11415	COG2140	Oxalate decarboxylase
PF976_11425	COG4347	Protein of unknown function (DUF1405)
PF976_11430	COG2010	Cytochrome c
PF976_11430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF976_11435	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF976_11440	COG0723	plastoquinol--plastocyanin reductase activity
PF976_11455	COG0457	Tetratricopeptide repeat
PF976_11465	COG0287	Prephenate dehydrogenase
PF976_11500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF976_11505	COG4401	Chorismate mutase type I
PF976_11520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF976_11525	COG0105	UTP biosynthetic process
PF976_11530	COG0142	geranyltranstransferase activity
PF976_11540	COG0142	geranyltranstransferase activity
PF976_11555	COG0776	regulation of translation
PF976_11560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF976_11600	COG0539	negative regulation of cytoplasmic translation
PF976_11615	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PF976_11620	COG2959	enzyme of heme biosynthesis
PF976_11625	COG3409	Peptidoglycan-binding domain 1 protein
PF976_11625	COG3773	Cell wall hydrolase
PF976_11630	COG2339	peptidase activity
PF976_11635	COG0492	ferredoxin-NADP+ reductase activity
PF976_11640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF976_11645	COG4862	establishment of competence for transformation
PF976_11650	COG1408	metallophosphoesterase
PF976_11660	COG1388	LysM domain
PF976_11665	COG1266	CAAX protease self-immunity
PF976_11670	COG0514	ATP-dependent DNA helicase (RecQ)
PF976_11675	COG4955	Helix-turn-helix domain
PF976_11680	COG1141	Ferredoxin
PF976_11685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PF976_11690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF976_11700	COG1595	DNA-templated transcription, initiation
PF976_11705	COG5002	protein histidine kinase activity
PF976_11710	COG0745	RESPONSE REGULATOR receiver
PF976_11715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF976_11720	COG1333	cytochrome c biogenesis protein
PF976_11725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_11730	COG1187	pseudouridine synthase activity
PF976_11735	COG0700	Nucleoside recognition
PF976_11740	COG2715	membrane protein required for spore maturation
PF976_11745	COG1686	Belongs to the peptidase S11 family
PF976_11770	COG1547	Domain of unknown function (DUF309)
PF976_11775	COG0456	acetyltransferase
PF976_11780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PF976_11785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF976_11785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF976_11790	COG0307	riboflavin synthase, alpha
PF976_11795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF976_11795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF976_11805	COG0681	Belongs to the peptidase S26 family
PF976_11815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF976_11820	COG4086	secreted protein
PF976_11825	COG0019	diaminopimelate decarboxylase activity
PF976_11830	COG0697	spore germination
PF976_11845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF976_11865	COG1191	sigma factor activity
PF976_11875	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_11880	COG1686	Belongs to the peptidase S11 family
PF976_11885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PF976_11890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PF976_11895	COG4974	Belongs to the 'phage' integrase family
PF976_11905	COG0735	belongs to the Fur family
PF976_11910	COG1300	Membrane
PF976_11925	COG0281	malic enzyme
PF976_11930	COG1757	Na H antiporter
PF976_11935	COG1027	Aspartate ammonia-lyase
PF976_11940	COG0252	asparaginase activity
PF976_11945	COG1396	sequence-specific DNA binding
PF976_11950	COG1379	DNA repair
PF976_11955	COG0494	nUDIX hydrolase
PF976_11965	COG0667	Aldo Keto reductase
PF976_11975	COG1073	alpha beta
PF976_11985	COG4918	Iron-sulphur cluster biosynthesis
PF976_11990	COG0456	acetyltransferase
PF976_11990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF976_11995	COG0456	acetyltransferase
PF976_12000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF976_12015	COG0628	permease
PF976_12030	COG3048	D-serine ammonia-lyase activity
PF976_12035	COG0300	oxidoreductase activity
PF976_12040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_12045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF976_12065	COG0596	Alpha beta hydrolase
PF976_12080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PF976_12085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF976_12100	COG0706	membrane insertase activity
PF976_12105	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF976_12110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF976_12115	COG0346	lactoylglutathione lyase activity
PF976_12125	COG1376	ErfK ybiS ycfS ynhG family protein
PF976_12130	COG4129	membrane
PF976_12135	COG1126	abc transporter atp-binding protein
PF976_12140	COG0765	amino acid transport
PF976_12145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_12155	COG1597	lipid kinase activity
PF976_12160	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF976_12165	COG0022	dehydrogenase e1 component
PF976_12170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF976_12175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF976_12180	COG3426	butyrate kinase activity
PF976_12185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF976_12190	COG0280	phosphate acetyltransferase
PF976_12195	COG3829	transcription factor binding
PF976_12195	COG3290	protein histidine kinase activity
PF976_12205	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PF976_12210	COG2079	MmgE PrpD family protein
PF976_12215	COG0372	Belongs to the citrate synthase family
PF976_12220	COG1960	acyl-CoA dehydrogenase activity
PF976_12225	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF976_12230	COG0183	Belongs to the thiolase family
PF976_12235	COG0584	glycerophosphoryl diester phosphodiesterase
PF976_12240	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF976_12265	COG1902	pentaerythritol trinitrate reductase activity
PF976_12280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF976_12290	COG0745	RESPONSE REGULATOR receiver
PF976_12295	COG0750	zinc metalloprotease
PF976_12300	COG0497	DNA recombination
PF976_12310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PF976_12320	COG0142	geranyltranstransferase activity
PF976_12330	COG1570	exodeoxyribonuclease VII activity
PF976_12345	COG1302	Protein conserved in bacteria
PF976_12350	COG0439	Biotin carboxylase
PF976_12355	COG0511	ligase activity, forming carbon-carbon bonds
PF976_12395	COG3854	ATPases associated with a variety of cellular activities
PF976_12410	COG0006	proline dipeptidase activity
PF976_12420	COG3872	metal-dependent enzyme
PF976_12430	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF976_12445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF976_12465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF976_12480	COG1396	sequence-specific DNA binding
PF976_12490	COG0681	Belongs to the peptidase S26 family
PF976_12515	COG4940	Competence protein ComGF
PF976_12525	COG4970	Tfp pilus assembly protein FimT
PF976_12530	COG4537	Required for transformation and DNA binding
PF976_12535	COG1459	type II secretion system
PF976_12540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF976_12545	COG0598	Magnesium transport protein CorA
PF976_12555	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_12565	COG1393	Belongs to the ArsC family
PF976_12575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_12585	COG0011	TIGRFAM Protein of
PF976_12595	COG2866	Carboxypeptidase
PF976_12600	COG1940	carbohydrate kinase activity
PF976_12605	COG4483	Protein conserved in bacteria
PF976_12610	COG1757	Na H antiporter
PF976_12620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF976_12635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF976_12640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF976_12645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF976_12650	COG0581	inorganic phosphate transmembrane transporter activity
PF976_12655	COG0573	inorganic phosphate transmembrane transporter activity
PF976_12660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF976_12665	COG0768	penicillin binding
PF976_12670	COG0477	Major facilitator Superfamily
PF976_12675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF976_12680	COG2839	Protein conserved in bacteria
PF976_12685	COG5521	maltodextrose utilization protein MalA
PF976_12690	COG1388	LysM domain
PF976_12700	COG4709	membrane
PF976_12705	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
PF976_12710	COG0735	belongs to the Fur family
PF976_12715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_12730	COG0513	Belongs to the DEAD box helicase family
PF976_12745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF976_12750	COG2384	SAM-dependent methyltransferase
PF976_12755	COG2010	Cytochrome c
PF976_12760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PF976_12765	COG0358	DNA primase activity
PF976_12780	COG0517	IMP dehydrogenase activity
PF976_12785	COG0751	glycine-tRNA ligase activity
PF976_12805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF976_12810	COG0295	cytidine deaminase activity
PF976_12815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PF976_12825	COG1480	7TM receptor with intracellular HD hydrolase
PF976_12830	COG1702	phosphate starvation-inducible protein PhoH
PF976_12835	COG0561	phosphatase activity
PF976_12850	COG4864	UPF0365 protein
PF976_12855	COG1030	water channel activity
PF976_12860	COG1610	YqeY-like protein
PF976_12870	COG1283	sodium-dependent phosphate transmembrane transporter activity
PF976_12875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF976_12880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF976_12910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF976_12925	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF976_12960	COG2131	deaminase
PF976_12965	COG1555	photosystem II stabilization
PF976_12965	COG1596	polysaccharide export
PF976_12970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF976_12975	COG2226	methyltransferase
PF976_12980	COG0799	negative regulation of ribosome biogenesis
PF976_12985	COG1713	HD superfamily hydrolase involved in NAD metabolism
PF976_12995	COG1534	Rna-binding protein
PF976_13000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF976_13005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF976_13010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PF976_13025	COG2755	lipolytic protein G-D-S-L family
PF976_13035	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF976_13035	COG3409	Peptidoglycan-binding domain 1 protein
PF976_13040	COG0398	Pfam SNARE associated Golgi protein
PF976_13075	COG0563	adenylate kinase activity
PF976_13085	COG2814	Major facilitator Superfamily
PF976_13095	COG2318	DinB family
PF976_13100	COG0561	phosphatase activity
PF976_13105	COG0561	phosphatase activity
PF976_13115	COG1482	cell wall glycoprotein biosynthetic process
PF976_13120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF976_13120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF976_13120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_13125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_13125	COG3711	transcriptional antiterminator
PF976_13135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF976_13140	COG0583	DNA-binding transcription factor activity
PF976_13145	COG2814	Major facilitator Superfamily
PF976_13150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF976_13150	COG2124	cytochrome p450
PF976_13155	COG1309	transcriptional regulator
PF976_13160	COG2226	methyltransferase
PF976_13175	COG2116	formate transmembrane transporter activity
PF976_13180	COG5609	conserved protein (DUF2294)
PF976_13185	COG3383	formate dehydrogenase (NAD+) activity
PF976_13190	COG2427	Protein of unknown function (DUF1641)
PF976_13200	COG0626	cystathionine gamma-synthase activity
PF976_13205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF976_13230	COG0768	penicillin binding
PF976_13245	COG0826	peptidase U32
PF976_13250	COG0826	peptidase U32
PF976_13255	COG4122	O-methyltransferase activity
PF976_13260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF976_13275	COG4472	Bacterial protein of unknown function (DUF965)
PF976_13285	COG0628	permease
PF976_13290	COG1126	abc transporter atp-binding protein
PF976_13295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_13300	COG0765	amino acid transport
PF976_13305	COG0765	amino acid transport
PF976_13320	COG3881	PFAM PRC-barrel domain
PF976_13325	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF976_13330	COG0457	Tetratricopeptide repeat
PF976_13340	COG1104	cysteine desulfurase activity
PF976_13345	COG1959	2 iron, 2 sulfur cluster binding
PF976_13350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF976_13355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF976_13380	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF976_13380	COG3103	Sh3 type 3 domain protein
PF976_13380	COG4991	sh3 domain protein
PF976_13385	COG1490	D-aminoacyl-tRNA deacylase activity
PF976_13390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF976_13400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF976_13400	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PF976_13405	COG5416	Lipopolysaccharide assembly protein A domain
PF976_13410	COG0490	domain, Protein
PF976_13415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF976_13415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF976_13425	COG2244	polysaccharide biosynthetic process
PF976_13430	COG2323	membrane
PF976_13440	COG1862	Preprotein translocase
PF976_13480	COG1388	LysM domain
PF976_13490	COG0157	Belongs to the NadC ModD family
PF976_13495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PF976_13500	COG1104	cysteine desulfurase activity
PF976_13505	COG1827	regulation of RNA biosynthetic process
PF976_13510	COG0077	Prephenate dehydratase
PF976_13525	COG3290	protein histidine kinase activity
PF976_13530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PF976_13535	COG2868	ribosomal protein
PF976_13545	COG1994	Peptidase M50
PF976_13550	COG0739	heme binding
PF976_13555	COG2894	cell division
PF976_13560	COG0850	regulation of cytokinetic process
PF976_13565	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF976_13575	COG1077	Cell shape determining protein MreB Mrl
PF976_13595	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PF976_13600	COG0285	dihydrofolate synthase activity
PF976_13605	COG0525	valine-tRNA ligase activity
PF976_13615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF976_13620	COG1388	LysM domain
PF976_13630	COG0113	porphobilinogen synthase activity
PF976_13635	COG1587	Uroporphyrinogen-III synthase
PF976_13645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF976_13665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF976_13670	COG0470	DNA polymerase III
PF976_13670	COG1067	ATP-dependent peptidase activity
PF976_13685	COG0457	Tetratricopeptide repeat
PF976_13685	COG1477	protein flavinylation
PF976_13700	COG0473	3-isopropylmalate dehydrogenase activity
PF976_13715	COG0440	acetolactate synthase activity
PF976_13720	COG0028	Belongs to the TPP enzyme family
PF976_13745	COG0622	Phosphoesterase
PF976_13750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PF976_13760	COG5401	PFAM Sporulation and spore germination
PF976_13770	COG1846	Transcriptional regulator
PF976_13775	COG2197	response regulator
PF976_13780	COG0824	Thioesterase
PF976_13785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF976_13790	COG1053	succinate dehydrogenase
PF976_13795	COG2009	succinate dehydrogenase
PF976_13800	COG1719	4-vinyl reductase, 4VR
PF976_13805	COG0527	aspartate kinase activity
PF976_13815	COG3118	belongs to the thioredoxin family
PF976_13820	COG3534	alpha-L-arabinofuranosidase
PF976_13825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PF976_13830	COG2086	electron transfer activity
PF976_13835	COG1024	Enoyl-CoA hydratase
PF976_13840	COG1309	transcriptional regulator
PF976_13845	COG0318	PFAM AMP-dependent synthetase and ligase
PF976_13855	COG3766	membrane
PF976_13865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF976_13865	COG1796	DNA polymerase
PF976_13870	COG1286	toxin biosynthetic process
PF976_13885	COG0072	phenylalanine-tRNA ligase activity
PF976_13885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF976_13890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PF976_13895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF976_13905	COG3835	regulator
PF976_13910	COG0277	FAD linked oxidase domain protein
PF976_13915	COG0247	lactate metabolic process
PF976_13920	COG1966	Carbon starvation protein
PF976_13925	COG3534	alpha-L-arabinofuranosidase
PF976_13930	COG0395	ABC-type sugar transport system, permease component
PF976_13935	COG1175	transmembrane transport
PF976_13940	COG1653	transport
PF976_13950	COG0647	UMP catabolic process
PF976_13955	COG0235	Class ii aldolase
PF976_13960	COG1069	ribulokinase activity
PF976_13965	COG2160	L-arabinose isomerase activity
PF976_13970	COG3507	Belongs to the glycosyl hydrolase 43 family
PF976_13975	COG1363	Peptidase, m42
PF976_13985	COG3326	Membrane
PF976_13990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PF976_14000	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PF976_14005	COG1346	cytolysis
PF976_14010	COG1380	Effector of murein hydrolase LrgA
PF976_14015	COG3279	Response regulator of the LytR AlgR family
PF976_14020	COG3275	phosphorelay sensor kinase activity
PF976_14025	COG1011	Hydrolase
PF976_14040	COG0398	Pfam SNARE associated Golgi protein
PF976_14045	COG1484	DNA-dependent DNA replication
PF976_14050	COG3611	Membrane attachment protein
PF976_14065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF976_14070	COG1733	regulation of RNA biosynthetic process
PF976_14075	COG2814	Major facilitator Superfamily
PF976_14080	COG0656	L-ascorbic acid biosynthetic process
PF976_14085	COG0237	dephospho-CoA kinase activity
PF976_14090	COG1971	Probably functions as a manganese efflux pump
PF976_14095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PF976_14100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF976_14100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF976_14105	COG5002	protein histidine kinase activity
PF976_14110	COG0745	RESPONSE REGULATOR receiver
PF976_14120	COG0538	isocitrate dehydrogenase activity
PF976_14125	COG0372	Belongs to the citrate synthase family
PF976_14135	COG0628	permease
PF976_14140	COG3030	protein affecting phage T7 exclusion by the F plasmid
PF976_14145	COG0469	pyruvate kinase activity
PF976_14165	COG0281	malic enzyme
PF976_14170	COG0587	DNA-directed DNA polymerase activity
PF976_14190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PF976_14200	COG4109	DRTGG domain
PF976_14210	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_14230	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF976_14240	COG0827	DNA restriction-modification system
PF976_14245	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PF976_14250	COG3874	Sporulation protein YtfJ
PF976_14260	COG1714	RDD family
PF976_14265	COG0616	signal peptide processing
PF976_14270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF976_14275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PF976_14280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF976_14295	COG1104	cysteine desulfurase activity
PF976_14300	COG1114	Component of the transport system for branched-chain amino acids
PF976_14310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF976_14315	COG1309	transcriptional regulator
PF976_14320	COG1956	GAF domain-containing protein
PF976_14325	COG2203	Gaf domain
PF976_14325	COG2199	diguanylate cyclase activity
PF976_14335	COG1017	nitric oxide dioxygenase activity
PF976_14335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF976_14365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF976_14370	COG1378	Sugar-specific transcriptional regulator TrmB
PF976_14375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF976_14395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF976_14400	COG0454	-acetyltransferase
PF976_14405	COG0517	IMP dehydrogenase activity
PF976_14410	COG0123	including yeast histone deacetylase and acetoin utilization protein
PF976_14415	COG1360	Flagellar Motor Protein
PF976_14420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF976_14425	COG1609	Transcriptional regulator
PF976_14430	COG1605	Chorismate mutase
PF976_14430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PF976_14435	COG3118	belongs to the thioredoxin family
PF976_14440	COG4980	gas vesicle protein
PF976_14445	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF976_14455	COG1674	ftsk spoiiie
PF976_14460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF976_14470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_14480	COG1363	Peptidase, m42
PF976_14485	COG5584	Small secreted protein
PF976_14490	COG0281	malic enzyme
PF976_14495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF976_14510	COG0510	thiamine kinase activity
PF976_14515	COG1597	lipid kinase activity
PF976_14525	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF976_14530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF976_14535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF976_14540	COG2252	PERMEase
PF976_14545	COG4473	ABC transporter
PF976_14550	COG1131	(ABC) transporter
PF976_14555	COG1349	DNA-binding transcription factor activity
PF976_14560	COG1187	pseudouridine synthase activity
PF976_14565	COG2244	polysaccharide biosynthetic process
PF976_14570	COG2081	HI0933 family
PF976_14575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF976_14585	COG1609	Transcriptional regulator
PF976_14590	COG1653	transport
PF976_14595	COG1175	transmembrane transport
PF976_14600	COG0395	ABC-type sugar transport system, permease component
PF976_14605	COG1486	melibiose metabolic process
PF976_14615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF976_14630	COG2202	Pas domain
PF976_14630	COG1366	Belongs to the anti-sigma-factor antagonist family
PF976_14635	COG2814	Major facilitator Superfamily
PF976_14640	COG5522	Integral membrane protein (intg_mem_TP0381)
PF976_14645	COG0577	efflux transmembrane transporter activity
PF976_14650	COG1136	(ABC) transporter
PF976_14655	COG2205	protein histidine kinase activity
PF976_14660	COG0745	RESPONSE REGULATOR receiver
PF976_14665	COG0577	efflux transmembrane transporter activity
PF976_14670	COG1136	(ABC) transporter
PF976_14690	COG1131	(ABC) transporter
PF976_14695	COG1725	Transcriptional regulator
PF976_14710	COG1242	4 iron, 4 sulfur cluster binding
PF976_14715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PF976_14730	COG2267	carboxylic ester hydrolase activity
PF976_14735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF976_14740	COG1113	amino acid transport
PF976_14745	COG0367	asparagine synthase
PF976_14765	COG1506	peptidase
PF976_14770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF976_14775	COG1116	anion transmembrane transporter activity
PF976_14780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF976_14785	COG0494	nUDIX hydrolase
PF976_14790	COG4824	toxin secretion phage lysis holin
PF976_14795	COG0783	Belongs to the Dps family
PF976_14820	COG0288	reversible hydration of carbon dioxide
PF976_14830	COG1271	oxidase subunit
PF976_14835	COG1294	oxidase, subunit
PF976_14845	COG4948	Mandelate Racemase Muconate Lactonizing
PF976_14855	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PF976_14860	COG0596	Alpha beta hydrolase
PF976_14870	COG1169	isochorismate synthase
PF976_14875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF976_14880	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PF976_15005	COG3859	Proton-coupled thiamine transporter YuaJ
PF976_15010	COG2268	Band 7 protein
PF976_15015	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF976_15020	COG2318	DinB family
PF976_15030	COG1454	alcohol dehydrogenase
PF976_15035	COG1012	belongs to the aldehyde dehydrogenase family
PF976_15040	COG1510	regulation of RNA biosynthetic process
PF976_15050	COG0569	domain protein
PF976_15055	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF976_15060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF976_15060	COG1017	nitric oxide dioxygenase activity
PF976_15075	COG0457	Tetratricopeptide repeat
PF976_15095	COG0628	permease
PF976_15100	COG0673	inositol 2-dehydrogenase activity
PF976_15105	COG0693	protein deglycase activity
PF976_15110	COG0840	transmembrane signaling receptor activity
PF976_15115	COG0840	transmembrane signaling receptor activity
PF976_15120	COG0840	transmembrane signaling receptor activity
PF976_15125	COG0840	transmembrane signaling receptor activity
PF976_15140	COG2070	2-Nitropropane dioxygenase
PF976_15150	COG0366	Alpha amylase catalytic
PF976_15155	COG1253	flavin adenine dinucleotide binding
PF976_15160	COG2738	Putative neutral zinc metallopeptidase
PF976_15175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF976_15195	COG1979	alcohol dehydrogenase
PF976_15200	COG1979	alcohol dehydrogenase
PF976_15205	COG2155	Conserved Protein
PF976_15210	COG1098	S1 RNA binding domain
PF976_15215	COG0436	Aminotransferase
PF976_15220	COG1522	sequence-specific DNA binding
PF976_15225	COG2267	carboxylic ester hydrolase activity
PF976_15235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PF976_15240	COG2205	protein histidine kinase activity
PF976_15250	COG5018	Exonuclease
PF976_15255	COG2814	Major facilitator Superfamily
PF976_15260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF976_15265	COG3011	Protein conserved in bacteria
PF976_15275	COG3290	protein histidine kinase activity
PF976_15280	COG4565	transcriptional regulatory protein
PF976_15285	COG1744	ABC transporter substrate-binding protein PnrA-like
PF976_15290	COG3845	ABC transporter
PF976_15295	COG4603	Belongs to the binding-protein-dependent transport system permease family
PF976_15300	COG1079	Belongs to the binding-protein-dependent transport system permease family
PF976_15310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF976_15310	COG2111	Na H antiporter
PF976_15315	COG2111	Na H antiporter
PF976_15320	COG1006	Multisubunit Na H antiporter MnhC subunit
PF976_15325	COG0651	ATP synthesis coupled electron transport
PF976_15330	COG1863	multisubunit Na H antiporter MnhE subunit
PF976_15335	COG2212	antiporter activity
PF976_15340	COG1320	monovalent cation:proton antiporter activity
PF976_15345	COG2050	protein possibly involved in aromatic compounds catabolism
PF976_15350	COG2197	response regulator
PF976_15355	COG4585	Histidine kinase
PF976_15365	COG0142	geranyltranstransferase activity
PF976_15380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PF976_15385	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PF976_15390	COG1335	isochorismatase
PF976_15395	COG5506	Protein of unknown function (DUF1694)
PF976_15410	COG0628	permease
PF976_15420	COG1418	mRNA catabolic process
PF976_15425	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_15435	COG1511	domain protein
PF976_15440	COG1674	ftsk spoiiie
PF976_15440	COG0433	COG0433 Predicted ATPase
PF976_15445	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF976_15450	COG5417	Belongs to the EsaB family
PF976_15455	COG4842	Belongs to the WXG100 family
PF976_15460	COG2508	Transcriptional regulator
PF976_15460	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF976_15465	COG0686	Belongs to the AlaDH PNT family
PF976_15470	COG5634	Uncharacterized conserved protein (DUF2278)
PF976_15475	COG3251	PFAM MbtH domain protein
PF976_15480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF976_15485	COG1535	isochorismatase
PF976_15485	COG3433	isochorismatase activity
PF976_15490	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF976_15495	COG1169	isochorismate synthase
PF976_15500	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_15505	COG2819	hydrolase of the alpha beta superfamily
PF976_15510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF976_15515	COG1268	BioY protein
PF976_15520	COG2056	Na+-H+ antiporter family
PF976_15530	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
PF976_15535	COG3584	3D domain protein
PF976_15550	COG1252	NADH dehydrogenase
PF976_15580	COG1131	(ABC) transporter
PF976_15605	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PF976_15610	COG0316	Belongs to the HesB IscA family
PF976_15620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF976_15630	COG1252	NADH dehydrogenase
PF976_15635	COG4837	Protein of unknown function (DUF1462)
PF976_15640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PF976_15645	COG0823	Involved in the tonB-independent uptake of proteins
PF976_15645	COG1506	peptidase
PF976_15645	COG4946	Tricorn protease homolog
PF976_15655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF976_15660	COG0460	homoserine dehydrogenase
PF976_15665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF976_15670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF976_15675	COG0647	UMP catabolic process
PF976_15680	COG2445	Protein of unknown function DUF86
PF976_15685	COG4470	Protein conserved in bacteria
PF976_15695	COG0739	heme binding
PF976_15705	COG0737	Belongs to the 5'-nucleotidase family
PF976_15710	COG0730	response to heat
PF976_15715	COG1801	Protein of unknown function DUF72
PF976_15730	COG2508	Transcriptional regulator
PF976_15740	COG3195	allantoin biosynthetic process
PF976_15740	COG3648	Uricase
PF976_15750	COG2814	Major facilitator Superfamily
PF976_15755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF976_15760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF976_15765	COG2356	endonuclease I
PF976_15770	COG3842	ATPase activity
PF976_15775	COG2188	Transcriptional regulator
PF976_15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF976_15785	COG0395	ABC-type sugar transport system, permease component
PF976_15790	COG1175	transmembrane transport
PF976_15795	COG1653	transport
PF976_15800	COG2222	sugar isomerase
PF976_15805	COG0789	Transcriptional regulator
PF976_15830	COG0322	excinuclease ABC activity
PF976_15835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF976_15840	COG2226	methyltransferase
PF976_15850	COG3409	Peptidoglycan-binding domain 1 protein
PF976_15855	COG0719	Fe-S assembly protein
PF976_15860	COG0822	iron-sulfur transferase activity
PF976_15865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF976_15870	COG0719	Fe-S assembly protein
PF976_15875	COG0396	ATPase activity
PF976_15885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF976_15890	COG1464	Belongs to the NlpA lipoprotein family
PF976_15895	COG2011	ABC-type metal ion transport system permease component
PF976_15900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF976_15910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF976_15915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF976_15930	COG1393	Belongs to the ArsC family
PF976_15935	COG1960	acyl-CoA dehydrogenase activity
PF976_15940	COG0183	Belongs to the thiolase family
PF976_15945	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF976_15945	COG1024	Enoyl-CoA hydratase
PF976_15965	COG5577	PFAM Coat F domain
PF976_15970	COG1846	Transcriptional regulator
PF976_15975	COG0477	Major facilitator Superfamily
PF976_16000	COG1120	ATPase activity
PF976_16015	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_16020	COG0783	Belongs to the Dps family
PF976_16025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF976_16030	COG0745	RESPONSE REGULATOR receiver
PF976_16035	COG2770	Histidine kinase
PF976_16035	COG2205	protein histidine kinase activity
PF976_16045	COG1309	transcriptional regulator
PF976_16050	COG0114	fumarate hydratase activity
PF976_16060	COG0697	spore germination
PF976_16065	COG0814	amino acid
PF976_16075	COG2197	response regulator
PF976_16080	COG4585	Histidine kinase
PF976_16085	COG4758	membrane
PF976_16090	COG3595	metallopeptidase activity
PF976_16095	COG1842	Phage shock protein A
PF976_16100	COG4758	membrane
PF976_16105	COG2814	Major facilitator Superfamily
PF976_16110	COG2096	Adenosyltransferase
PF976_16115	COG1120	ATPase activity
PF976_16120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_16125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF976_16130	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_16135	COG3386	PFAM SMP-30 Gluconolaconase
PF976_16140	COG2205	protein histidine kinase activity
PF976_16145	COG0745	RESPONSE REGULATOR receiver
PF976_16155	COG1191	sigma factor activity
PF976_16165	COG2140	Oxalate decarboxylase
PF976_16175	COG1120	ATPase activity
PF976_16180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_16185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_16190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF976_16195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF976_16200	COG0531	amino acid
PF976_16210	COG1988	membrane-bound metal-dependent
PF976_16220	COG1910	domain protein
PF976_16225	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF976_16230	COG4149	molybdate abc transporter
PF976_16235	COG2197	response regulator
PF976_16245	COG1131	(ABC) transporter
PF976_16255	COG0842	Transport permease protein
PF976_16260	COG0656	L-ascorbic acid biosynthetic process
PF976_16280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF976_16285	COG3973	AAA domain
PF976_16290	COG2860	membrane
PF976_16300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF976_16305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF976_16310	COG2217	Heavy metal translocating P-type atpase
PF976_16315	COG2217	Heavy metal translocating P-type atpase
PF976_16320	COG2608	mercury ion transmembrane transporter activity
PF976_16325	COG1937	Protein conserved in bacteria
PF976_16330	COG0673	inositol 2-dehydrogenase activity
PF976_16340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_16345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF976_16350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_16355	COG1126	abc transporter atp-binding protein
PF976_16360	COG0765	amino acid transport
PF976_16365	COG0765	amino acid transport
PF976_16370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_16375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF976_16380	COG0454	-acetyltransferase
PF976_16385	COG0583	DNA-binding transcription factor activity
PF976_16390	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_16395	COG2732	(Barnase) inhibitor
PF976_16410	COG0557	exoribonuclease II activity
PF976_16415	COG1647	Serine aminopeptidase, S33
PF976_16420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF976_16425	COG1476	TRANSCRIPTIONal
PF976_16430	COG1396	sequence-specific DNA binding
PF976_16435	COG1396	sequence-specific DNA binding
PF976_16440	COG1733	regulation of RNA biosynthetic process
PF976_16465	COG1131	(ABC) transporter
PF976_16470	COG1174	glycine betaine transport
PF976_16475	COG1732	Glycine betaine
PF976_16480	COG1174	glycine betaine transport
PF976_16485	COG1125	glycine betaine transport
PF976_16485	COG0517	IMP dehydrogenase activity
PF976_16490	COG1510	regulation of RNA biosynthetic process
PF976_16495	COG1174	glycine betaine transport
PF976_16500	COG1732	Glycine betaine
PF976_16505	COG1174	glycine betaine transport
PF976_16510	COG0517	IMP dehydrogenase activity
PF976_16510	COG1125	glycine betaine transport
PF976_16515	COG1510	regulation of RNA biosynthetic process
PF976_16520	COG2095	MarC family integral membrane protein
PF976_16525	COG3064	Membrane
PF976_16530	COG4640	response to antibiotic
PF976_16535	COG0456	acetyltransferase
PF976_16550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF976_16570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF976_16575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF976_16585	COG2234	aminopeptidase activity
PF976_16605	COG0126	phosphoglycerate kinase activity
PF976_16610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF976_16615	COG2390	Transcriptional regulator
PF976_16625	COG1609	Transcriptional regulator
PF976_16630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_16635	COG0583	DNA-binding transcription factor activity
PF976_16640	COG0697	spore germination
PF976_16645	COG1113	amino acid transport
PF976_16655	COG1737	Transcriptional regulator
PF976_16660	COG1070	Carbohydrate kinase
PF976_16690	COG2186	Transcriptional regulator
PF976_16695	COG1620	l-lactate permease
PF976_16700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PF976_16710	COG5039	Polysaccharide pyruvyl transferase
PF976_16715	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF976_16720	COG0110	maltose O-acetyltransferase activity
PF976_16725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF976_16730	COG2244	polysaccharide biosynthetic process
PF976_16735	COG1216	Glycosyl transferase, family 2
PF976_16740	COG5039	Polysaccharide pyruvyl transferase
PF976_16745	COG1216	Glycosyl transferase, family 2
PF976_16755	COG0438	transferase activity, transferring glycosyl groups
PF976_16760	COG1215	transferase activity, transferring glycosyl groups
PF976_16765	COG0438	transferase activity, transferring glycosyl groups
PF976_16770	COG1086	Polysaccharide biosynthesis protein
PF976_16775	COG0489	protein tyrosine kinase activity
PF976_16780	COG3944	biosynthesis protein
PF976_16785	COG1396	sequence-specific DNA binding
PF976_16790	COG2272	Belongs to the type-B carboxylesterase lipase family
PF976_16800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF976_16815	COG2364	Membrane
PF976_16820	COG0456	acetyltransferase
PF976_16825	COG3479	Phenolic acid decarboxylase
PF976_16875	COG2223	nitrite transmembrane transporter activity
PF976_16880	COG1609	Transcriptional regulator
PF976_16890	COG0583	DNA-binding transcription factor activity
PF976_16895	COG2828	Protein conserved in bacteria
PF976_16900	COG0477	Major facilitator Superfamily
PF976_16900	COG2814	Major facilitator Superfamily
PF976_16910	COG1611	Belongs to the LOG family
PF976_16920	COG0659	secondary active sulfate transmembrane transporter activity
PF976_16925	COG0288	reversible hydration of carbon dioxide
PF976_16930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF976_16935	COG4290	ribonuclease
PF976_16940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PF976_16945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF976_16955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PF976_16965	COG1051	belongs to the nudix hydrolase family
PF976_16970	COG0492	ferredoxin-NADP+ reductase activity
PF976_16975	COG0791	NLP P60 protein
PF976_16975	COG3883	PFAM NLP P60 protein
PF976_16980	COG0457	Tetratricopeptide repeat
PF976_16985	COG5002	protein histidine kinase activity
PF976_16990	COG0745	RESPONSE REGULATOR receiver
PF976_16995	COG1132	(ABC) transporter
PF976_17000	COG0140	phosphoribosyl-ATP diphosphatase activity
PF976_17000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF976_17025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF976_17040	COG4990	cell redox homeostasis
PF976_17045	COG0110	maltose O-acetyltransferase activity
PF976_17065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PF976_17075	COG2188	Transcriptional regulator
PF976_17080	COG1309	transcriptional regulator
PF976_17085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF976_17090	COG1950	PFAM Membrane protein of
PF976_17095	COG1983	PspC domain protein
PF976_17100	COG3595	metallopeptidase activity
PF976_17115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF976_17125	COG4897	Protein conserved in bacteria
PF976_17130	COG0574	Belongs to the PEP-utilizing enzyme family
PF976_17130	COG3848	Pyruvate phosphate dikinase
PF976_17135	COG1309	transcriptional regulator
PF976_17140	COG2814	Major facilitator Superfamily
PF976_17155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF976_17165	COG0793	Belongs to the peptidase S41A family
PF976_17165	COG3409	Peptidoglycan-binding domain 1 protein
PF976_17170	COG3420	alginic acid biosynthetic process
PF976_17175	COG2177	Part of the ABC transporter FtsEX involved in
PF976_17180	COG2884	Cell division ATP-binding protein ftsE
PF976_17185	COG2010	Cytochrome c
PF976_17190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_17205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PF976_17220	COG1516	flagellar protein fliS
PF976_17225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PF976_17230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF976_17250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF976_17255	COG4786	Flagellar basal body rod
PF976_17255	COG1256	bacterial-type flagellum assembly
PF976_17260	COG3418	PFAM FlgN family protein
PF976_17265	COG2747	anti-sigma28 factor FlgM
PF976_17275	COG1040	competence protein
PF976_17290	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PF976_17295	COG1307	EDD domain protein, DegV family
PF976_17300	COG2197	response regulator
PF976_17305	COG4585	Histidine kinase
PF976_17310	COG1739	Uncharacterized protein family UPF0029
PF976_17315	COG1316	TRANSCRIPTIONal
PF976_17320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF976_17325	COG0438	transferase activity, transferring glycosyl groups
PF976_17330	COG1215	transferase activity, transferring glycosyl groups
PF976_17335	COG3206	protein involved in exopolysaccharide biosynthesis
PF976_17340	COG3307	-O-antigen
PF976_17345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF976_17350	COG0438	transferase activity, transferring glycosyl groups
PF976_17350	COG0297	glycogen (starch) synthase activity
PF976_17355	COG2244	polysaccharide biosynthetic process
PF976_17365	COG2247	cell wall binding repeat
PF976_17365	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF976_17370	COG2385	sporulation resulting in formation of a cellular spore
PF976_17370	COG2247	cell wall binding repeat
PF976_17380	COG1316	TRANSCRIPTIONal
PF976_17385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PF976_17390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF976_17395	COG1134	teichoic acid transport
PF976_17400	COG1682	transport, permease protein
PF976_17405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF976_17410	COG0438	transferase activity, transferring glycosyl groups
PF976_17415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PF976_17420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PF976_17425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF976_17430	COG4193	domain, Protein
PF976_17435	COG1482	cell wall glycoprotein biosynthetic process
PF976_17445	COG0814	amino acid
PF976_17460	COG2814	Major facilitator Superfamily
PF976_17465	COG1316	TRANSCRIPTIONal
PF976_17470	COG0561	phosphatase activity
PF976_17475	COG2433	Pfam Transposase IS66
PF976_17480	COG0791	NLP P60 protein
PF976_17490	COG2843	Capsule synthesis protein
PF976_17500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF976_17505	COG0697	spore germination
PF976_17510	COG0814	amino acid
PF976_17520	COG1609	Transcriptional regulator
PF976_17525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF976_17535	COG1129	ABC transporter
PF976_17540	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF976_17545	COG1879	ABC-type sugar transport system periplasmic component
PF976_17550	COG3103	Sh3 type 3 domain protein
PF976_17555	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF976_17560	COG3527	Alpha-acetolactate decarboxylase
PF976_17565	COG0028	Belongs to the TPP enzyme family
PF976_17570	COG0583	DNA-binding transcription factor activity
PF976_17575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF976_17590	COG5337	Spore coat protein CotH
PF976_17600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF976_17610	COG0405	Gamma-glutamyltransferase
PF976_17615	COG1522	sequence-specific DNA binding
PF976_17620	COG2059	Chromate
PF976_17625	COG2059	Chromate
PF976_17660	COG5444	nuclease activity
PF976_17675	COG3878	Protein conserved in bacteria
PF976_17680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF976_17685	COG4464	protein tyrosine phosphatase activity
PF976_17690	COG0489	protein tyrosine kinase activity
PF976_17695	COG3944	biosynthesis protein
PF976_17705	COG4715	Zinc finger, swim domain protein
PF976_17710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF976_17715	COG0561	phosphatase activity
PF976_17720	COG1349	DNA-binding transcription factor activity
PF976_17725	COG0629	single-stranded DNA binding
PF976_17750	COG0457	Tetratricopeptide repeat
PF976_17755	COG4786	Flagellar basal body rod
PF976_17760	COG4786	Flagellar basal body rod
PF976_17765	COG1077	Cell shape determining protein MreB Mrl
PF976_17770	COG1609	Transcriptional regulator
PF976_17775	COG1846	Transcriptional regulator
PF976_17780	COG2814	Major facilitator Superfamily
PF976_17785	COG1953	Uracil, thiamine, allantoin
PF976_17790	COG0477	Major facilitator Superfamily
PF976_17795	COG1335	isochorismatase
PF976_17800	COG0004	ammonium transporteR
PF976_17805	COG0347	Belongs to the P(II) protein family
PF976_17810	COG0772	Belongs to the SEDS family
PF976_17815	COG0671	phosphoesterase, PA-phosphatase related
PF976_17825	COG0739	heme binding
PF976_17830	COG1247	-acetyltransferase
PF976_17845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF976_17860	COG2910	NAD(P)H-binding
PF976_17865	COG1959	2 iron, 2 sulfur cluster binding
PF976_17880	COG0831	urea catabolic process
PF976_17885	COG3237	CsbD-like
PF976_17890	COG1994	Peptidase M50
PF976_17895	COG0457	Tetratricopeptide repeat
PF976_17905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF976_17915	COG2304	oxidoreductase activity
PF976_17920	COG2304	oxidoreductase activity
PF976_17925	COG2385	sporulation resulting in formation of a cellular spore
PF976_17930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF976_17940	COG4836	Membrane
PF976_18010	COG0698	ribose 5-phosphate isomerase
PF976_18015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF976_18025	COG0009	L-threonylcarbamoyladenylate synthase
PF976_18030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PF976_18050	COG2890	protein-(glutamine-N5) methyltransferase activity
PF976_18055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PF976_18060	COG0346	lactoylglutathione lyase activity
PF976_18065	COG0789	Transcriptional regulator
PF976_18070	COG0679	Auxin Efflux Carrier
PF976_18075	COG0281	malic enzyme
PF976_18090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PF976_18095	COG1494	fructose-1,6-bisphosphatase
PF976_18100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF976_18110	COG0191	fructose-bisphosphate aldolase activity
PF976_18115	COG2204	response regulator
PF976_18120	COG4821	SIS domain
PF976_18135	COG2181	nitrate reductase activity
PF976_18135	COG0247	lactate metabolic process
PF976_18140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF976_18155	COG1132	(ABC) transporter
PF976_18160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF976_18165	COG2181	nitrate reductase activity
PF976_18170	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
PF976_18175	COG1140	nitrate reductase beta subunit
PF976_18180	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PF976_18185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF976_18195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF976_18200	COG2223	nitrite transmembrane transporter activity
PF976_18210	COG4506	Protein conserved in bacteria
PF976_18220	COG3391	amine dehydrogenase activity
PF976_18225	COG0457	Tetratricopeptide repeat
PF976_18235	COG0010	Belongs to the arginase family
PF976_18240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PF976_18245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF976_18260	COG1994	Peptidase M50
PF976_18265	COG1942	4-Oxalocrotonate Tautomerase
PF976_18270	COG1846	Transcriptional regulator
PF976_18275	COG0531	amino acid
PF976_18280	COG3465	dGTPase activity
PF976_18285	COG1078	dGTPase activity
PF976_18300	COG1695	Transcriptional regulator
PF976_18310	COG1131	(ABC) transporter
PF976_18320	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF976_18350	COG0583	DNA-binding transcription factor activity
PF976_18355	COG2855	membrane
PF976_18360	COG0280	phosphate acetyltransferase
PF976_18370	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_18375	COG0436	Aminotransferase
PF976_18385	COG0151	Belongs to the GarS family
PF976_18395	COG1917	Cupin 2, conserved barrel domain protein
PF976_18400	COG0077	Prephenate dehydratase
PF976_18405	COG2814	Major facilitator Superfamily
PF976_18410	COG2814	Major facilitator Superfamily
PF976_18415	COG0833	amino acid
PF976_18420	COG4187	Peptidase family M20/M25/M40
PF976_18425	COG1012	belongs to the aldehyde dehydrogenase family
PF976_18430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF976_18440	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PF976_18445	COG1091	dTDP-4-dehydrorhamnose reductase activity
PF976_18450	COG1088	dTDP-glucose 4,6-dehydratase activity
PF976_18455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PF976_18460	COG3980	spore coat polysaccharide biosynthesis protein
PF976_18465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PF976_18470	COG2089	acid synthase
PF976_18475	COG0456	acetyltransferase
PF976_18480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF976_18485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF976_18490	COG0463	Glycosyl transferase, family 2
PF976_18500	COG2363	Small membrane protein
PF976_18505	COG2233	PERMEase
PF976_18520	COG1216	Glycosyl transferase, family 2
PF976_18525	COG0351	phosphomethylpyrimidine kinase
PF976_18535	COG1621	beta-fructofuranosidase activity
PF976_18540	COG1263	PTS System
PF976_18540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_18545	COG3711	transcriptional antiterminator
PF976_18555	COG1404	Belongs to the peptidase S8 family
PF976_18560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF976_18565	COG2378	regulation of single-species biofilm formation
PF976_18585	COG0778	Nitroreductase
PF976_18590	COG0772	Belongs to the SEDS family
PF976_18615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF976_18620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF976_18625	COG2261	transglycosylase associated protein
PF976_18630	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PF976_18635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PF976_18640	COG2246	polysaccharide biosynthetic process
PF976_18645	COG1309	transcriptional regulator
PF976_18665	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF976_18670	COG2837	iron assimilation
PF976_18675	COG2822	iron ion transport
PF976_18680	COG0672	)-iron permease
PF976_18695	COG0583	DNA-binding transcription factor activity
PF976_18705	COG1346	cytolysis
PF976_18710	COG4895	conserved protein (DUF2196)
PF976_18715	COG0789	Transcriptional regulator
PF976_18720	COG5504	Zn-dependent protease
PF976_18725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF976_18730	COG0346	lactoylglutathione lyase activity
PF976_18735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_18740	COG1404	Belongs to the peptidase S8 family
PF976_18745	COG1442	glycosyl transferase family 8
PF976_18750	COG2357	RelA SpoT domain protein
PF976_18755	COG1575	Belongs to the MenA family. Type 1 subfamily
PF976_18770	COG1696	Membrane protein involved in D-alanine export
PF976_18780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PF976_18785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF976_18790	COG1486	melibiose metabolic process
PF976_18795	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF976_18800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_18805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_18825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_18830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF976_18840	COG0640	Transcriptional regulator
PF976_18845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF976_18850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_18855	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF976_18860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF976_18865	COG2723	6-phospho-beta-galactosidase activity
PF976_18870	COG1940	carbohydrate kinase activity
PF976_18875	COG1482	cell wall glycoprotein biosynthetic process
PF976_18885	COG0753	catalase activity
PF976_18890	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PF976_18895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF976_18900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF976_18905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PF976_18910	COG4988	ABC transporter
PF976_18915	COG1294	oxidase, subunit
PF976_18920	COG1271	oxidase subunit
PF976_18925	COG3493	citrate carrier protein
PF976_18930	COG0726	polysaccharide deacetylase
PF976_18935	COG3842	ATPase activity
PF976_18945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_18955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF976_18970	COG4894	glucomannan catabolic process
PF976_18975	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF976_18980	COG0500	methyltransferase
PF976_18985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF976_19005	COG0753	catalase activity
PF976_19005	COG0693	protein deglycase activity
PF976_19010	COG2851	Citrate transporter
PF976_19015	COG2273	Hydrolase Family 16
PF976_19020	COG3711	transcriptional antiterminator
PF976_19025	COG2270	Major facilitator Superfamily
PF976_19030	COG0513	Belongs to the DEAD box helicase family
PF976_19080	COG0697	spore germination
PF976_19085	COG0589	response to stress
PF976_19090	COG2723	6-phospho-beta-galactosidase activity
PF976_19095	COG2190	(PTS) system
PF976_19095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF976_19095	COG1263	PTS System
PF976_19110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF976_19130	COG3507	Belongs to the glycosyl hydrolase 43 family
PF976_19155	COG0010	Belongs to the arginase family
PF976_19160	COG0833	amino acid
PF976_19165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PF976_19170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF976_19180	COG2390	Transcriptional regulator
PF976_19185	COG0561	phosphatase activity
PF976_19215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF976_19220	COG5294	Protein conserved in bacteria
PF976_19225	COG0577	efflux transmembrane transporter activity
PF976_19230	COG1136	(ABC) transporter
PF976_19235	COG2205	protein histidine kinase activity
PF976_19240	COG0745	RESPONSE REGULATOR receiver
PF976_19255	COG1082	Xylose isomerase domain protein TIM barrel
PF976_19265	COG2814	Major facilitator Superfamily
PF976_19295	COG1349	DNA-binding transcription factor activity
PF976_19300	COG0667	Aldo Keto reductase
PF976_19305	COG2814	Major facilitator Superfamily
PF976_19315	COG1028	Short-chain dehydrogenase reductase Sdr
PF976_19320	COG2197	response regulator
PF976_19325	COG4585	Histidine kinase
PF976_19330	COG3239	Fatty acid desaturase
PF976_19335	COG1309	transcriptional regulator
PF976_19340	COG1012	belongs to the aldehyde dehydrogenase family
PF976_19345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF976_19355	COG0640	Transcriptional regulator
PF976_19360	COG2814	Major facilitator Superfamily
PF976_19365	COG1714	RDD family
PF976_19375	COG0450	alkyl hydroperoxide reductase
PF976_19380	COG3634	alkyl hydroperoxide reductase activity
PF976_19390	COG1113	amino acid transport
PF976_19445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF976_19460	COG2323	membrane
PF976_19470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF976_19475	COG2323	membrane
PF976_19485	COG2080	2 iron, 2 sulfur cluster binding
PF976_19495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF976_19500	COG2068	MobA-Related Protein
PF976_19505	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PF976_19555	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PF976_19560	COG0667	Aldo Keto reductase
PF976_19565	COG0456	acetyltransferase
PF976_19575	COG0457	Tetratricopeptide repeat
PF976_19580	COG0010	Belongs to the arginase family
PF976_19585	COG0833	amino acid
PF976_19590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF976_19595	COG5658	integral membrane protein
PF976_19600	COG0640	Transcriptional regulator
PF976_19605	COG3829	transcription factor binding
PF976_19620	COG5002	protein histidine kinase activity
PF976_19620	COG3850	Histidine kinase
PF976_19625	COG0745	RESPONSE REGULATOR receiver
PF976_19635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF976_19640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF976_19645	COG4853	Protein conserved in bacteria
PF976_19650	COG4863	YycH protein
PF976_19655	COG5002	protein histidine kinase activity
PF976_19660	COG0745	RESPONSE REGULATOR receiver
PF976_19690	COG0346	lactoylglutathione lyase activity
PF976_19695	COG0305	Participates in initiation and elongation during chromosome replication
PF976_19710	COG3093	addiction module antidote protein HigA
PF976_19730	COG0438	transferase activity, transferring glycosyl groups
PF976_19750	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PF976_19755	COG4241	membrane
PF976_19765	COG5577	PFAM Coat F domain
PF976_19770	COG1733	regulation of RNA biosynthetic process
PF976_19780	COG0697	spore germination
PF976_19785	COG1621	beta-fructofuranosidase activity
PF976_19790	COG1621	beta-fructofuranosidase activity
PF976_19800	COG2318	DinB family
PF976_19805	COG2211	Major facilitator Superfamily
PF976_19815	COG0778	Nitroreductase
PF976_19820	COG1846	Transcriptional regulator
PF976_19825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF976_19830	COG1846	Transcriptional regulator
PF976_19835	COG2153	protein acetylation
PF976_19840	COG0640	Transcriptional regulator
PF976_19845	COG2267	carboxylic ester hydrolase activity
PF976_19860	COG1331	Highly conserved protein containing a thioredoxin domain
PF976_19865	COG1331	Highly conserved protein containing a thioredoxin domain
PF976_19870	COG1266	CAAX protease self-immunity
PF976_19875	COG0477	Major facilitator Superfamily
PF976_19875	COG2814	Major facilitator Superfamily
PF976_19880	COG0346	lactoylglutathione lyase activity
PF976_19885	COG1609	Transcriptional regulator
PF976_19890	COG0708	Exodeoxyribonuclease III
PF976_19895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF976_19900	COG2169	Transcriptional regulator
PF976_19910	COG0629	single-stranded DNA binding
PF976_19920	COG0012	GTP binding
PF976_19925	COG0243	molybdopterin cofactor binding
PF976_19930	COG4481	Protein conserved in bacteria
PF976_19935	COG3949	Membrane
PF976_19950	COG1475	DNA binding
PF976_19955	COG1192	Involved in chromosome partitioning
PF976_19980	COG1847	R3H domain protein
PF976_19985	COG0706	membrane insertase activity
PF976_20005	COG0592	DNA-directed DNA polymerase activity
PF976_20010	COG2501	S4 domain
PF976_20025	COG0187	DNA topoisomerase II activity
PF976_20030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF976_20065	COG0516	GMP reductase activity
PF976_20065	COG0517	IMP dehydrogenase activity
PF976_20070	COG1686	Belongs to the peptidase S11 family
PF976_20090	COG1929	Belongs to the glycerate kinase type-1 family
PF976_20100	COG1428	Deoxynucleoside kinase
PF976_20105	COG1428	Deoxynucleoside kinase
PF976_20110	COG1388	LysM domain
PF976_20110	COG3858	chitin binding
PF976_20115	COG1335	isochorismatase
PF976_20120	COG0590	tRNA wobble adenosine to inosine editing
PF976_20130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF976_20135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PF976_20185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
PF976_20190	COG3853	Toxic anion resistance protein (TelA)