locus-tag	class	description
J4048_00010	COG0592	DNA-directed DNA polymerase activity
J4048_00015	COG2501	S4 domain
J4048_00030	COG0187	DNA topoisomerase II activity
J4048_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4048_00070	COG0516	GMP reductase activity
J4048_00070	COG0517	IMP dehydrogenase activity
J4048_00075	COG1686	Belongs to the peptidase S11 family
J4048_00095	COG1929	Belongs to the glycerate kinase type-1 family
J4048_00105	COG1428	Deoxynucleoside kinase
J4048_00110	COG1428	Deoxynucleoside kinase
J4048_00115	COG1388	LysM domain
J4048_00115	COG3858	chitin binding
J4048_00120	COG1335	isochorismatase
J4048_00125	COG0590	tRNA wobble adenosine to inosine editing
J4048_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4048_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J4048_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4048_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
J4048_00195	COG3853	Toxic anion resistance protein (TelA)
J4048_00200	COG1982	Orn Lys Arg decarboxylase major
J4048_00210	COG3870	Protein conserved in bacteria
J4048_00215	COG1728	Protein conserved in bacteria
J4048_00220	COG0470	DNA polymerase III
J4048_00225	COG1774	PSP1 C-terminal conserved region
J4048_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J4048_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J4048_00250	COG2002	toxin-antitoxin pair type II binding
J4048_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4048_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4048_00260	COG0084	hydrolase, TatD family'
J4048_00265	COG3583	domain protein
J4048_00265	COG3584	3D domain protein
J4048_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
J4048_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4048_00285	COG4466	Protein conserved in bacteria
J4048_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4048_00305	COG0251	oxidation-reduction process
J4048_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4048_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4048_00345	COG2002	toxin-antitoxin pair type II binding
J4048_00350	COG2244	polysaccharide biosynthetic process
J4048_00355	COG3956	TIGRFAM MazG family protein
J4048_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J4048_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J4048_00380	COG1098	S1 RNA binding domain
J4048_00395	COG2208	phosphoserine phosphatase activity
J4048_00400	COG2304	oxidoreductase activity
J4048_00405	COG0515	serine threonine protein kinase
J4048_00410	COG0037	tRNA processing
J4048_00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J4048_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4048_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4048_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4048_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4048_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
J4048_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4048_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4048_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4048_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4048_00475	COG1396	sequence-specific DNA binding
J4048_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4048_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J4048_00565	COG4463	regulation of RNA biosynthetic process
J4048_00570	COG3880	PFAM UvrB UvrC protein
J4048_00580	COG0542	response to heat
J4048_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J4048_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J4048_00595	COG4956	integral membrane protein (PIN domain superfamily)
J4048_00615	COG1045	serine acetyltransferase
J4048_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
J4048_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4048_00635	COG3688	RNA-binding protein containing a PIN domain
J4048_00640	COG1595	DNA-templated transcription, initiation
J4048_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4048_00655	COG0250	Participates in transcription elongation, termination and antitermination
J4048_00680	COG2813	Specifically methylates the guanine in position
J4048_00695	COG1358	cellular component organization or biogenesis
J4048_00720	COG0596	Alpha beta hydrolase
J4048_00830	COG0201	protein transport
J4048_00840	COG0024	Methionine aminopeptidase
J4048_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4048_00875	COG1122	ATPase activity
J4048_00880	COG1122	ATPase activity
J4048_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4048_00905	COG2226	methyltransferase
J4048_00910	COG2318	DinB family
J4048_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_00925	COG0489	protein tyrosine kinase activity
J4048_00935	COG2194	sulfuric ester hydrolase activity
J4048_00940	COG0726	polysaccharide deacetylase
J4048_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J4048_01020	COG0659	secondary active sulfate transmembrane transporter activity
J4048_01025	COG0385	Bile acid
J4048_01030	COG2819	hydrolase of the alpha beta superfamily
J4048_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4048_01050	COG2207	Transcriptional regulator
J4048_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4048_01055	COG3876	Protein conserved in bacteria
J4048_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
J4048_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4048_01070	COG1263	PTS System
J4048_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_01085	COG1683	Conserved Protein
J4048_01115	COG1595	DNA-templated transcription, initiation
J4048_01120	COG5662	AntiSigma factor
J4048_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J4048_01130	COG4856	YbbR-like protein
J4048_01170	COG1346	cytolysis
J4048_01175	COG1380	Effector of murein hydrolase LrgA
J4048_01180	COG1846	Transcriptional regulator
J4048_01185	COG1113	amino acid transport
J4048_01190	COG1011	Hydrolase
J4048_01195	COG4585	Histidine kinase
J4048_01200	COG2197	response regulator
J4048_01205	COG1131	(ABC) transporter
J4048_01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_01250	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_01250	COG3321	synthase
J4048_01250	COG4221	oxidoreductase activity
J4048_01255	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_01255	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_01255	COG0300	oxidoreductase activity
J4048_01255	COG3321	synthase
J4048_01255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_01295	COG0531	amino acid
J4048_01300	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
J4048_01315	COG0584	glycerophosphoryl diester phosphodiesterase
J4048_01320	COG2271	Major facilitator Superfamily
J4048_01330	COG2368	4-hydroxyphenylacetate
J4048_01340	COG3409	Peptidoglycan-binding domain 1 protein
J4048_01355	COG0371	Dehydrogenase
J4048_01365	COG1183	phosphatidylcholine synthase activity
J4048_01370	COG0586	Pfam SNARE associated Golgi protein
J4048_01375	COG0688	phosphatidylethanolamine metabolic process
J4048_01390	COG1301	dicarboxylic acid transport
J4048_01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4048_01400	COG0833	amino acid
J4048_01405	COG2040	homocysteine
J4048_01410	COG1115	amino acid carrier protein
J4048_01415	COG2066	Belongs to the glutaminase family
J4048_01420	COG4191	Histidine kinase
J4048_01425	COG0784	Response regulator, receiver
J4048_01440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4048_01445	COG0778	Nitroreductase
J4048_01450	COG0346	lactoylglutathione lyase activity
J4048_01455	COG2259	Doxx family
J4048_01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_01470	COG3773	Cell wall hydrolase
J4048_01475	COG3540	Alkaline phosphatase
J4048_01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4048_01485	COG0805	protein transport
J4048_01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4048_01500	COG0477	Major facilitator Superfamily
J4048_01505	COG1309	transcriptional regulator
J4048_01510	COG0252	asparaginase activity
J4048_01515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
J4048_01520	COG3012	SEC-C Motif Domain Protein
J4048_01520	COG1405	negative regulation of cell septum assembly
J4048_01525	COG0667	Aldo Keto reductase
J4048_01535	COG1595	DNA-templated transcription, initiation
J4048_01540	COG1595	DNA-templated transcription, initiation
J4048_01545	COG1876	peptidase activity
J4048_01550	COG0457	Tetratricopeptide repeat
J4048_01555	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_01560	COG0366	Alpha amylase catalytic
J4048_01565	COG0803	Belongs to the bacterial solute-binding protein 9 family
J4048_01570	COG1121	(ABC) transporter
J4048_01575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4048_01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_01585	COG2310	stress, protein
J4048_01590	COG2310	stress, protein
J4048_01595	COG2310	stress, protein
J4048_01600	COG0861	Integral membrane protein TerC family
J4048_01610	COG3853	Toxic anion resistance protein (TelA)
J4048_01615	COG0477	Major facilitator Superfamily
J4048_01620	COG4175	Glycine betaine
J4048_01620	COG0517	IMP dehydrogenase activity
J4048_01625	COG4176	ABC-type proline glycine betaine transport system permease component
J4048_01630	COG2113	Glycine betaine
J4048_01635	COG1473	amidohydrolase
J4048_01640	COG1288	antiporter activity
J4048_01650	COG0366	Alpha amylase catalytic
J4048_01660	COG2814	Major facilitator Superfamily
J4048_01665	COG1846	Transcriptional regulator
J4048_01670	COG1280	lysine exporter protein (LysE YggA)
J4048_01675	COG3403	YqcI/YcgG family
J4048_01680	COG1113	amino acid transport
J4048_01685	COG3665	Urea carboxylase-associated protein
J4048_01700	COG1660	Displays ATPase and GTPase activities
J4048_01705	COG1082	Xylose isomerase domain protein TIM barrel
J4048_01710	COG2271	Major facilitator Superfamily
J4048_01715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4048_01720	COG3458	cephalosporin-C deacetylase activity
J4048_01725	COG3541	Predicted nucleotidyltransferase
J4048_01730	COG0506	proline dehydrogenase activity
J4048_01735	COG1012	belongs to the aldehyde dehydrogenase family
J4048_01740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4048_01745	COG2508	Transcriptional regulator
J4048_01755	COG1587	Uroporphyrinogen-III synthase
J4048_01755	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4048_01760	COG2146	nitrite reductase [NAD(P)H] activity
J4048_01765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4048_01770	COG0243	molybdopterin cofactor binding
J4048_01775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J4048_01780	COG2223	nitrite transmembrane transporter activity
J4048_01785	COG0523	cobalamin synthesis protein
J4048_01790	COG1063	alcohol dehydrogenase
J4048_01795	COG1714	RDD family
J4048_01805	COG2723	6-phospho-beta-galactosidase activity
J4048_01815	COG3209	COG3209 Rhs family protein
J4048_01820	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4048_01825	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
J4048_01830	COG1733	regulation of RNA biosynthetic process
J4048_01835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_01840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_01850	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
J4048_01865	COG0697	spore germination
J4048_01870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_01880	COG2364	Membrane
J4048_01885	COG1126	abc transporter atp-binding protein
J4048_01890	COG0765	amino acid transport
J4048_01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_01900	COG0583	DNA-binding transcription factor activity
J4048_01905	COG0163	prenyltransferase activity
J4048_01910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
J4048_01925	COG3104	oligopeptide transport
J4048_01930	COG5434	Belongs to the glycosyl hydrolase 28 family
J4048_01940	COG0697	spore germination
J4048_01950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J4048_01955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_01960	COG0456	acetyltransferase
J4048_01965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_01970	COG0765	amino acid transport
J4048_01975	COG1126	abc transporter atp-binding protein
J4048_01980	COG1473	amidohydrolase
J4048_01985	COG2079	MmgE PrpD family protein
J4048_01990	COG1136	(ABC) transporter
J4048_01995	COG0577	efflux transmembrane transporter activity
J4048_02000	COG0745	RESPONSE REGULATOR receiver
J4048_02005	COG3850	Histidine kinase
J4048_02005	COG5002	protein histidine kinase activity
J4048_02010	COG0457	Tetratricopeptide repeat
J4048_02025	COG0527	aspartate kinase activity
J4048_02030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_02035	COG4605	iron ion homeostasis
J4048_02040	COG4604	ABC transporter, ATP-binding protein
J4048_02045	COG4607	ABC-type enterochelin transport system periplasmic component
J4048_02050	COG2814	Major facilitator Superfamily
J4048_02055	COG1309	transcriptional regulator
J4048_02060	COG0778	Nitroreductase
J4048_02065	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
J4048_02070	COG0640	Transcriptional regulator
J4048_02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_02080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J4048_02085	COG1012	belongs to the aldehyde dehydrogenase family
J4048_02090	COG4975	Glucose uptake
J4048_02095	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_02100	COG4549	nuclear export factor GLE1
J4048_02105	COG1276	copper resistance
J4048_02105	COG2372	response to copper ion
J4048_02110	COG1349	DNA-binding transcription factor activity
J4048_02120	COG2213	PTS system mannitol-specific
J4048_02125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_02135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4048_02145	COG0561	phosphatase activity
J4048_02155	COG1914	H( )-stimulated, divalent metal cation uptake system
J4048_02165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J4048_02170	COG1984	allophanate hydrolase subunit 2
J4048_02175	COG1414	Transcriptional regulator
J4048_02180	COG2755	lipolytic protein G-D-S-L family
J4048_02190	COG2329	Antibiotic biosynthesis monooxygenase
J4048_02195	COG0768	penicillin binding
J4048_02200	COG4989	oxidoreductase activity
J4048_02205	COG3711	transcriptional antiterminator
J4048_02210	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_02215	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_02220	COG1917	Cupin 2, conserved barrel domain protein
J4048_02225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_02230	COG3871	stress protein (general stress protein 26)
J4048_02240	COG2814	Major facilitator Superfamily
J4048_02245	COG1522	sequence-specific DNA binding
J4048_02250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4048_02250	COG0551	DNA topoisomerase type I activity
J4048_02255	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J4048_02260	COG3706	GGDEF domain
J4048_02265	COG5298	Protein conserved in bacteria
J4048_02270	COG1215	transferase activity, transferring glycosyl groups
J4048_02280	COG0531	amino acid
J4048_02285	COG0494	nUDIX hydrolase
J4048_02290	COG0028	Belongs to the TPP enzyme family
J4048_02320	COG0457	Tetratricopeptide repeat
J4048_02345	COG1914	H( )-stimulated, divalent metal cation uptake system
J4048_02355	COG4876	unkown
J4048_02365	COG2076	Multidrug Resistance protein
J4048_02370	COG2217	Heavy metal translocating P-type atpase
J4048_02375	COG3729	General stress protein
J4048_02380	COG0662	Cupin 2, conserved barrel domain protein
J4048_02385	COG2329	Antibiotic biosynthesis monooxygenase
J4048_02390	COG3546	catalase activity
J4048_02395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J4048_02400	COG3290	protein histidine kinase activity
J4048_02405	COG4565	transcriptional regulatory protein
J4048_02410	COG1301	dicarboxylic acid transport
J4048_02415	COG0628	permease
J4048_02420	COG1131	(ABC) transporter
J4048_02425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
J4048_02435	COG1960	acyl-CoA dehydrogenase activity
J4048_02450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4048_02455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4048_02470	COG0513	Belongs to the DEAD box helicase family
J4048_02475	COG3402	PFAM membrane-flanked domain
J4048_02480	COG3428	Bacterial PH domain
J4048_02485	COG0705	Rhomboid family
J4048_02495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J4048_02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4048_02505	COG0864	Transcriptional regulator
J4048_02510	COG2337	Toxic component of a toxin-antitoxin (TA) module
J4048_02515	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_02520	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_02525	COG2172	sigma factor antagonist activity
J4048_02530	COG2208	phosphoserine phosphatase activity
J4048_02535	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_02545	COG1191	sigma factor activity
J4048_02550	COG2208	phosphoserine phosphatase activity
J4048_02555	COG2183	response to ionizing radiation
J4048_02605	COG0582	viral genome integration into host DNA
J4048_02610	COG2856	Zn peptidase
J4048_02615	COG1396	sequence-specific DNA binding
J4048_02640	COG1674	ftsk spoiiie
J4048_02645	COG2946	Replication initiation factor
J4048_02685	COG0433	COG0433 Predicted ATPase
J4048_02695	COG5644	endopeptidase inhibitor activity
J4048_02700	COG0791	NLP P60 protein
J4048_02700	COG0741	lytic transglycosylase activity
J4048_02720	COG0457	Tetratricopeptide repeat
J4048_02730	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4048_02745	COG0477	Major facilitator Superfamily
J4048_02750	COG1846	Transcriptional regulator
J4048_02760	COG2030	dehydratase
J4048_02775	COG1959	2 iron, 2 sulfur cluster binding
J4048_02780	COG2910	NAD(P)H-binding
J4048_02785	COG3239	Fatty acid desaturase
J4048_02795	COG1278	Cold shock
J4048_02800	COG1329	Transcriptional regulator
J4048_02805	COG1794	racemase activity, acting on amino acids and derivatives
J4048_02820	COG3621	Patatin-like phospholipase
J4048_02830	COG0662	Cupin 2, conserved barrel domain protein
J4048_02845	COG0277	FAD linked oxidase domain protein
J4048_02870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4048_02895	COG1064	alcohol dehydrogenase
J4048_02900	COG0789	Transcriptional regulator
J4048_02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_02925	COG2814	Major facilitator Superfamily
J4048_02930	COG1309	transcriptional regulator
J4048_02935	COG0697	spore germination
J4048_02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_02945	COG5577	PFAM Coat F domain
J4048_02955	COG1063	alcohol dehydrogenase
J4048_02960	COG5577	PFAM Coat F domain
J4048_02970	COG4585	Histidine kinase
J4048_02975	COG2197	response regulator
J4048_02980	COG2409	Drug exporters of the RND superfamily
J4048_02985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4048_02990	COG0488	(ABC) transporter
J4048_02995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_03000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_03010	COG2814	Major facilitator Superfamily
J4048_03015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4048_03025	COG0730	response to heat
J4048_03030	COG0456	acetyltransferase
J4048_03040	COG1051	belongs to the nudix hydrolase family
J4048_03045	COG2226	methyltransferase
J4048_03065	COG1802	Transcriptional regulator
J4048_03070	COG1819	glycosyl
J4048_03085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4048_03095	COG1388	LysM domain
J4048_03100	COG2814	Major facilitator Superfamily
J4048_03105	COG2188	Transcriptional regulator
J4048_03110	COG2186	Transcriptional regulator
J4048_03115	COG2807	transmembrane transport
J4048_03120	COG2076	Multidrug Resistance protein
J4048_03125	COG2076	Multidrug Resistance protein
J4048_03130	COG1309	transcriptional regulator
J4048_03135	COG0531	amino acid
J4048_03145	COG3832	glyoxalase III activity
J4048_03150	COG0604	alcohol dehydrogenase
J4048_03155	COG2814	Major facilitator Superfamily
J4048_03195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J4048_03200	COG0802	atpase or kinase
J4048_03205	COG1214	PFAM Peptidase M22, glycoprotease
J4048_03210	COG0456	acetyltransferase
J4048_03215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J4048_03220	COG0488	(ABC) transporter
J4048_03235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4048_03240	COG0805	protein transport
J4048_03250	COG1266	CAAX protease self-immunity
J4048_03270	COG0457	Tetratricopeptide repeat
J4048_03275	COG1063	alcohol dehydrogenase
J4048_03280	COG2211	Major facilitator Superfamily
J4048_03285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4048_03295	COG1842	Phage shock protein A
J4048_03300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4048_03305	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J4048_03310	COG4260	virion core protein, lumpy skin disease virus
J4048_03315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4048_03315	COG2755	lipolytic protein G-D-S-L family
J4048_03325	COG1595	DNA-templated transcription, initiation
J4048_03330	COG1063	alcohol dehydrogenase
J4048_03335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4048_03340	COG0823	Involved in the tonB-independent uptake of proteins
J4048_03355	COG2132	Multicopper oxidase
J4048_03360	COG1113	amino acid transport
J4048_03365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4048_03370	COG0714	Associated with various cellular activities
J4048_03375	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
J4048_03380	COG1305	Transglutaminase-like
J4048_03405	COG2252	PERMEase
J4048_03410	COG3064	Membrane
J4048_03430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J4048_03435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J4048_03440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4048_03445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4048_03450	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4048_03465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J4048_03475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4048_03480	COG0138	bifunctional purine biosynthesis protein purh
J4048_03485	COG0151	Belongs to the GarS family
J4048_03495	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J4048_03500	COG1470	cell adhesion involved in biofilm formation
J4048_03505	COG4496	protein, YerC YecD
J4048_03510	COG0069	glutamate synthase activity
J4048_03520	COG0210	DNA helicase
J4048_03530	COG4851	CamS sex pheromone cAM373 precursor
J4048_03535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4048_03540	COG1285	pathogenesis
J4048_03545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4048_03565	COG1309	transcriptional regulator
J4048_03570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J4048_03575	COG1597	lipid kinase activity
J4048_03580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4048_03590	COG1131	(ABC) transporter
J4048_03610	COG5444	nuclease activity
J4048_03640	COG3546	catalase activity
J4048_03645	COG0454	-acetyltransferase
J4048_03655	COG2323	membrane
J4048_03660	COG2329	Antibiotic biosynthesis monooxygenase
J4048_03665	COG0346	lactoylglutathione lyase activity
J4048_03670	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_03675	COG5583	Uncharacterized small protein (DUF2292)
J4048_03680	COG0196	riboflavin kinase activity
J4048_03685	COG0670	Belongs to the BI1 family
J4048_03695	COG1846	Transcriptional regulator
J4048_03700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4048_03710	COG2124	cytochrome p450
J4048_03710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4048_03725	COG1131	(ABC) transporter
J4048_03735	COG1368	sulfuric ester hydrolase activity
J4048_03740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J4048_03745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_03750	COG1442	glycosyl transferase family 8
J4048_03755	COG1216	Glycosyl transferase, family 2
J4048_03760	COG1442	glycosyl transferase family 8
J4048_03765	COG2223	nitrite transmembrane transporter activity
J4048_03770	COG0531	amino acid
J4048_03775	COG1012	belongs to the aldehyde dehydrogenase family
J4048_03780	COG0840	transmembrane signaling receptor activity
J4048_03785	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_03790	COG0457	Tetratricopeptide repeat
J4048_03790	COG0463	Glycosyl transferase, family 2
J4048_03795	COG0488	(ABC) transporter
J4048_03800	COG0789	Transcriptional regulator
J4048_03805	COG2814	Major facilitator Superfamily
J4048_03810	COG0488	(ABC) transporter
J4048_03815	COG0513	Belongs to the DEAD box helicase family
J4048_03820	COG0456	acetyltransferase
J4048_03825	COG2130	NADP-dependent
J4048_03840	COG3866	Pectate lyase
J4048_03845	COG0471	metal ion transport
J4048_03860	COG3290	protein histidine kinase activity
J4048_03865	COG4565	transcriptional regulatory protein
J4048_03870	COG3181	Tripartite tricarboxylate transporter family receptor
J4048_03875	COG2851	Citrate transporter
J4048_03880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_03885	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
J4048_03895	COG2258	MOSC domain
J4048_03915	COG0024	Methionine aminopeptidase
J4048_03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_03920	COG1263	PTS System
J4048_03930	COG1368	sulfuric ester hydrolase activity
J4048_03940	COG0071	Belongs to the small heat shock protein (HSP20) family
J4048_03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_03955	COG1263	PTS System
J4048_03960	COG0366	Alpha amylase catalytic
J4048_03965	COG2188	Transcriptional regulator
J4048_03970	COG0778	Nitroreductase
J4048_03985	COG0737	Belongs to the 5'-nucleotidase family
J4048_03990	COG0693	protein deglycase activity
J4048_03995	COG1609	Transcriptional regulator
J4048_04010	COG2814	Major facilitator Superfamily
J4048_04020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4048_04025	COG4980	gas vesicle protein
J4048_04030	COG1295	ribonuclease BN
J4048_04035	COG0477	Major facilitator Superfamily
J4048_04040	COG0387	Pfam Sodium calcium exchanger
J4048_04050	COG0668	transmembrane transport
J4048_04055	COG0535	radical SAM domain protein
J4048_04065	COG0726	polysaccharide deacetylase
J4048_04070	COG2084	Dehydrogenase
J4048_04080	COG0598	Magnesium transport protein CorA
J4048_04085	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
J4048_04090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4048_04105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4048_04110	COG4637	Psort location Cytoplasmic, score
J4048_04115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4048_04120	COG0022	dehydrogenase e1 component
J4048_04125	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4048_04130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4048_04135	COG3284	Transcriptional regulator
J4048_04145	COG1486	melibiose metabolic process
J4048_04150	COG1737	Transcriptional regulator
J4048_04155	COG1263	PTS System
J4048_04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_04160	COG1132	(ABC) transporter
J4048_04165	COG1132	(ABC) transporter
J4048_04170	COG2259	Doxx family
J4048_04175	COG2514	catechol 2,3-dioxygenase activity
J4048_04185	COG1695	Transcriptional regulator
J4048_04190	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4048_04195	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
J4048_04200	COG0574	Belongs to the PEP-utilizing enzyme family
J4048_04200	COG3848	Pyruvate phosphate dikinase
J4048_04205	COG2732	(Barnase) inhibitor
J4048_04210	COG2318	DinB family
J4048_04215	COG2814	Major facilitator Superfamily
J4048_04220	COG1846	Transcriptional regulator
J4048_04225	COG0392	lysyltransferase activity
J4048_04225	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J4048_04230	COG0384	phenazine biosynthesis protein PhzF
J4048_04235	COG0778	Nitroreductase
J4048_04250	COG1090	epimerase
J4048_04265	COG2814	Major facilitator Superfamily
J4048_04275	COG3591	Belongs to the peptidase S1B family
J4048_04290	COG3103	Sh3 type 3 domain protein
J4048_04295	COG5658	integral membrane protein
J4048_04300	COG0596	Alpha beta hydrolase
J4048_04305	COG0463	Glycosyl transferase, family 2
J4048_04310	COG4485	Bacterial membrane protein, YfhO
J4048_04315	COG1988	membrane-bound metal-dependent
J4048_04320	COG1194	a g-specific adenine glycosylase
J4048_04330	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_04350	COG1132	(ABC) transporter
J4048_04355	COG4129	membrane
J4048_04365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J4048_04370	COG0735	belongs to the Fur family
J4048_04495	COG1757	Na H antiporter
J4048_04500	COG3340	Belongs to the peptidase S51 family
J4048_04510	COG0277	FAD linked oxidase domain protein
J4048_04520	COG0747	negative chemotaxis
J4048_04525	COG0601	transmembrane transport
J4048_04530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4048_04535	COG0444	Belongs to the ABC transporter superfamily
J4048_04540	COG4608	Belongs to the ABC transporter superfamily
J4048_04545	COG0753	catalase activity
J4048_04555	COG1116	anion transmembrane transporter activity
J4048_04560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4048_04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4048_04585	COG1476	TRANSCRIPTIONal
J4048_04595	COG3382	B3 4 domain protein
J4048_04600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4048_04610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J4048_04615	COG0789	Transcriptional regulator
J4048_04620	COG1664	Polymer-forming cytoskeletal
J4048_04625	COG1664	Polymer-forming cytoskeletal
J4048_04630	COG2766	serine protein kinase
J4048_04640	COG1846	Transcriptional regulator
J4048_04645	COG1566	PFAM secretion protein HlyD family protein
J4048_04650	COG2814	Major facilitator Superfamily
J4048_04655	COG0655	NAD(P)H dehydrogenase (quinone) activity
J4048_04670	COG1725	Transcriptional regulator
J4048_04675	COG1131	(ABC) transporter
J4048_04680	COG1131	(ABC) transporter
J4048_04685	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
J4048_04690	COG1278	Cold shock
J4048_04695	COG1464	Belongs to the NlpA lipoprotein family
J4048_04700	COG3706	GGDEF domain
J4048_04705	COG1823	symporter activity
J4048_04725	COG5577	PFAM Coat F domain
J4048_04730	COG0737	Belongs to the 5'-nucleotidase family
J4048_04730	COG1525	nuclease
J4048_04730	COG4085	toxin activity
J4048_04735	COG3764	Sortase (surface protein transpeptidase)
J4048_04740	COG0564	pseudouridine synthase activity
J4048_04750	COG0517	IMP dehydrogenase activity
J4048_04755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4048_04760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4048_04760	COG3153	acetyltransferase
J4048_04765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J4048_04770	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
J4048_04775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J4048_04785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J4048_04790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4048_04800	COG2197	response regulator
J4048_04805	COG0431	NADPH-dependent FMN reductase
J4048_04820	COG0791	NLP P60 protein
J4048_04820	COG1388	LysM domain
J4048_04825	COG1959	2 iron, 2 sulfur cluster binding
J4048_04830	COG0668	transmembrane transport
J4048_04835	COG2719	SpoVR family
J4048_04840	COG1785	Belongs to the alkaline phosphatase family
J4048_04845	COG0791	NLP P60 protein
J4048_04845	COG1388	LysM domain
J4048_04850	COG0583	DNA-binding transcription factor activity
J4048_04855	COG0372	Belongs to the citrate synthase family
J4048_04860	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_04865	COG0531	amino acid
J4048_04870	COG0733	neurotransmitter:sodium symporter activity
J4048_04885	COG1595	DNA-templated transcription, initiation
J4048_04890	COG0204	Acyl-transferase
J4048_04895	COG1253	flavin adenine dinucleotide binding
J4048_04900	COG0789	Transcriptional regulator
J4048_04905	COG0436	Aminotransferase
J4048_04910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4048_04915	COG1253	flavin adenine dinucleotide binding
J4048_04920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4048_04925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4048_04930	COG0584	glycerophosphoryl diester phosphodiesterase
J4048_04940	COG0668	transmembrane transport
J4048_04945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4048_04950	COG0726	polysaccharide deacetylase
J4048_04955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4048_04960	COG3226	Transcriptional regulator
J4048_04970	COG0589	response to stress
J4048_04975	COG1132	(ABC) transporter
J4048_04980	COG1132	(ABC) transporter
J4048_04985	COG0702	epimerase
J4048_05000	COG0189	ligase activity
J4048_05005	COG0189	ligase activity
J4048_05020	COG4335	DNA alkylation repair
J4048_05025	COG0561	phosphatase activity
J4048_05030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4048_05040	COG0475	glutathione-regulated potassium exporter activity
J4048_05045	COG0490	domain, Protein
J4048_05055	COG1024	Enoyl-CoA hydratase
J4048_05065	COG4152	abc transporter atp-binding protein
J4048_05070	COG1668	transmembrane transport
J4048_05075	COG0420	3'-5' exonuclease activity
J4048_05080	COG4717	serine-type aminopeptidase activity
J4048_05095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4048_05130	COG4980	gas vesicle protein
J4048_05145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J4048_05150	COG0537	adenosine 5'-monophosphoramidase activity
J4048_05155	COG1131	(ABC) transporter
J4048_05160	COG4473	ABC transporter
J4048_05170	COG1473	amidohydrolase
J4048_05175	COG3069	C4-dicarboxylate transmembrane transporter activity
J4048_05180	COG2329	Antibiotic biosynthesis monooxygenase
J4048_05185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4048_05195	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J4048_05200	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
J4048_05205	COG1309	transcriptional regulator
J4048_05210	COG1511	domain protein
J4048_05215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4048_05225	COG1363	Peptidase, m42
J4048_05230	COG1301	dicarboxylic acid transport
J4048_05240	COG1234	tRNA 3'-trailer cleavage
J4048_05245	COG0095	Lipoate-protein ligase
J4048_05250	COG0702	epimerase
J4048_05255	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_05265	COG0501	Belongs to the peptidase M48B family
J4048_05270	COG1404	Belongs to the peptidase S8 family
J4048_05275	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J4048_05280	COG0406	alpha-ribazole phosphatase activity
J4048_05285	COG0183	Belongs to the thiolase family
J4048_05290	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_05295	COG1268	BioY protein
J4048_05300	COG0840	transmembrane signaling receptor activity
J4048_05305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4048_05305	COG0723	plastoquinol--plastocyanin reductase activity
J4048_05310	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_05320	COG4903	ComK protein
J4048_05330	COG5646	InterPro IPR014922
J4048_05355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4048_05370	COG0398	Pfam SNARE associated Golgi protein
J4048_05375	COG0681	Belongs to the peptidase S26 family
J4048_05380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J4048_05385	COG1846	Transcriptional regulator
J4048_05390	COG3180	Ammonia monooxygenase
J4048_05395	COG2814	Major facilitator Superfamily
J4048_05405	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
J4048_05425	COG0420	3'-5' exonuclease activity
J4048_05430	COG0419	ATPase involved in DNA repair
J4048_05435	COG1403	HNH endonuclease
J4048_05475	COG0179	Fumarylacetoacetate (FAA) hydrolase
J4048_05495	COG0367	asparagine synthase
J4048_05500	COG1562	ergosterol biosynthetic process
J4048_05505	COG0534	Mate efflux family protein
J4048_05510	COG1917	Cupin 2, conserved barrel domain protein
J4048_05510	COG2207	Transcriptional regulator
J4048_05515	COG2318	DinB family
J4048_05520	COG1279	arginine transmembrane transporter activity
J4048_05525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_05530	COG1357	PFAM Pentapeptide repeats (8 copies)
J4048_05535	COG2153	protein acetylation
J4048_05540	COG0646	methionine synthase
J4048_05540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4048_05550	COG2996	Protein conserved in bacteria
J4048_05555	COG1744	ABC transporter substrate-binding protein PnrA-like
J4048_05560	COG0840	transmembrane signaling receptor activity
J4048_05565	COG2124	cytochrome p450
J4048_05575	COG1307	EDD domain protein, DegV family
J4048_05580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_05600	COG0561	phosphatase activity
J4048_05605	COG1073	alpha beta
J4048_05610	COG2151	metal-sulfur cluster biosynthetic enzyme
J4048_05620	COG0277	FAD linked oxidase domain protein
J4048_05635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J4048_05645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4048_05650	COG0505	Belongs to the CarA family
J4048_05655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4048_05660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4048_05675	COG2267	carboxylic ester hydrolase activity
J4048_05685	COG1744	ABC transporter substrate-binding protein PnrA-like
J4048_05700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4048_05705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4048_05710	COG5504	Zn-dependent protease
J4048_05715	COG0444	Belongs to the ABC transporter superfamily
J4048_05720	COG4608	Belongs to the ABC transporter superfamily
J4048_05730	COG0601	transmembrane transport
J4048_05735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4048_05745	COG0180	Tryptophanyl-tRNA synthetase
J4048_05750	COG4166	transmembrane transport
J4048_05755	COG0601	transmembrane transport
J4048_05760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4048_05765	COG0444	Belongs to the ABC transporter superfamily
J4048_05770	COG4608	Belongs to the ABC transporter superfamily
J4048_05780	COG0456	acetyltransferase
J4048_05785	COG1393	Belongs to the ArsC family
J4048_05790	COG0861	Integral membrane protein TerC family
J4048_05795	COG4862	establishment of competence for transformation
J4048_05800	COG4469	Competence protein
J4048_05805	COG1164	Oligoendopeptidase f
J4048_05815	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J4048_05820	COG2346	COG2346, Truncated hemoglobins
J4048_05825	COG0741	lytic transglycosylase activity
J4048_05830	COG4116	CYTH
J4048_05840	COG2357	RelA SpoT domain protein
J4048_05845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4048_05850	COG0564	pseudouridine synthase activity
J4048_05860	COG0475	glutathione-regulated potassium exporter activity
J4048_05860	COG0569	domain protein
J4048_05865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J4048_05870	COG0352	thiamine-phosphate diphosphorylase activity
J4048_05875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4048_05880	COG2104	thiamine diphosphate biosynthetic process
J4048_05890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4048_05895	COG0351	phosphomethylpyrimidine kinase
J4048_05900	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J4048_05955	COG0210	DNA helicase
J4048_05975	COG1131	(ABC) transporter
J4048_05985	COG2153	protein acetylation
J4048_05995	COG2382	esterase
J4048_06000	COG0626	cystathionine gamma-synthase activity
J4048_06005	COG0626	cystathionine gamma-synthase activity
J4048_06050	COG3409	Peptidoglycan-binding domain 1 protein
J4048_06050	COG1388	LysM domain
J4048_06050	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4048_06075	COG5444	nuclease activity
J4048_06115	COG0135	phosphoribosylanthranilate isomerase activity
J4048_06125	COG2367	Beta-lactamase
J4048_06130	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
J4048_06135	COG0477	Major facilitator Superfamily
J4048_06140	COG1846	Transcriptional regulator
J4048_06150	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
J4048_06155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4048_06160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J4048_06165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_06165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_06170	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4048_06195	COG1285	pathogenesis
J4048_06210	COG2205	protein histidine kinase activity
J4048_06220	COG3383	formate dehydrogenase (NAD+) activity
J4048_06225	COG2427	Protein of unknown function (DUF1641)
J4048_06230	COG2124	cytochrome p450
J4048_06235	COG1819	glycosyl
J4048_06245	COG1587	Uroporphyrinogen-III synthase
J4048_06250	COG0390	transport system, permease component
J4048_06255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4048_06260	COG0697	spore germination
J4048_06265	COG4297	protein containing double-stranded beta helix domain
J4048_06275	COG1252	NADH dehydrogenase
J4048_06285	COG2211	Major facilitator Superfamily
J4048_06290	COG1609	Transcriptional regulator
J4048_06295	COG0246	Mannitol dehydrogenase
J4048_06300	COG2721	sulfolactate sulfo-lyase activity
J4048_06305	COG0730	response to heat
J4048_06310	COG2318	DinB family
J4048_06315	COG0457	Tetratricopeptide repeat
J4048_06325	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4048_06325	COG1388	LysM domain
J4048_06325	COG3409	Peptidoglycan-binding domain 1 protein
J4048_06335	COG4195	phage-related replication protein
J4048_06340	COG3546	catalase activity
J4048_06345	COG2856	Zn peptidase
J4048_06350	COG1396	sequence-specific DNA binding
J4048_06360	COG1522	sequence-specific DNA binding
J4048_06365	COG1484	DNA-dependent DNA replication
J4048_06385	COG1595	DNA-templated transcription, initiation
J4048_06390	COG3728	DNA packaging
J4048_06390	COG5484	DNA packaging
J4048_06395	COG1783	phage Terminase large subunit
J4048_06400	COG5518	Phage portal protein
J4048_06405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
J4048_06410	COG4653	Phage capsid family
J4048_06460	COG3953	SLT domain
J4048_06460	COG5412	phage tail tape measure protein
J4048_06460	COG3953	SLT domain
J4048_06460	COG5412	phage tail tape measure protein
J4048_06460	COG3953	SLT domain
J4048_06460	COG5412	phage tail tape measure protein
J4048_06465	COG1652	LysM domain
J4048_06470	COG4193	domain, Protein
J4048_06480	COG3628	GPW Gp25 family protein
J4048_06485	COG3299	homolog of phage Mu protein gp47
J4048_06490	COG3778	Protein conserved in bacteria
J4048_06530	COG3409	Peptidoglycan-binding domain 1 protein
J4048_06530	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4048_06545	COG0306	phosphate transporter
J4048_06550	COG1392	Phosphate transport regulator
J4048_06555	COG0531	amino acid
J4048_06560	COG0346	lactoylglutathione lyase activity
J4048_06565	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J4048_06570	COG0463	Glycosyl transferase, family 2
J4048_06580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4048_06585	COG0477	Major facilitator Superfamily
J4048_06590	COG2362	D-Aminopeptidase
J4048_06595	COG0601	transmembrane transport
J4048_06600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4048_06605	COG0444	Belongs to the ABC transporter superfamily
J4048_06610	COG4166	transmembrane transport
J4048_06615	COG1619	proteins homologs of microcin C7 resistance protein MccF
J4048_06620	COG4948	Mandelate Racemase Muconate Lactonizing
J4048_06625	COG0791	NLP P60 protein
J4048_06630	COG4608	Belongs to the ABC transporter superfamily
J4048_06635	COG2706	6-phosphogluconolactonase activity
J4048_06640	COG1834	amidinotransferase
J4048_06645	COG1607	acyl-coa hydrolase
J4048_06650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_06655	COG2076	Multidrug Resistance protein
J4048_06660	COG2076	Multidrug Resistance protein
J4048_06665	COG0788	formyltetrahydrofolate deformylase activity
J4048_06670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4048_06680	COG1764	response to oxidative stress
J4048_06685	COG1846	Transcriptional regulator
J4048_06690	COG1764	response to oxidative stress
J4048_06705	COG0463	Glycosyl transferase, family 2
J4048_06705	COG0457	Tetratricopeptide repeat
J4048_06715	COG2814	Major facilitator Superfamily
J4048_06720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4048_06730	COG1404	Belongs to the peptidase S8 family
J4048_06735	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_06740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4048_06745	COG1122	ATPase activity
J4048_06750	COG4721	ABC-type cobalt transport system, permease component
J4048_06755	COG1388	LysM domain
J4048_06755	COG3858	chitin binding
J4048_06765	COG2239	Acts as a magnesium transporter
J4048_06770	COG0789	Transcriptional regulator
J4048_06785	COG1846	Transcriptional regulator
J4048_06790	COG0726	polysaccharide deacetylase
J4048_06795	COG1793	dna ligase
J4048_06795	COG3285	dna ligase
J4048_06800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J4048_06805	COG0586	Pfam SNARE associated Golgi protein
J4048_06810	COG0861	Integral membrane protein TerC family
J4048_06815	COG1191	sigma factor activity
J4048_06840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4048_06845	COG2323	membrane
J4048_06855	COG3594	Acyltransferase
J4048_06860	COG5002	protein histidine kinase activity
J4048_06865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4048_06880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4048_06885	COG0436	Aminotransferase
J4048_06915	COG3852	Histidine kinase
J4048_06920	COG1846	Transcriptional regulator
J4048_06925	COG1360	Flagellar Motor Protein
J4048_06930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J4048_06935	COG0542	response to heat
J4048_06940	COG3949	Membrane
J4048_06955	COG0720	synthase
J4048_06960	COG0602	queuosine metabolic process
J4048_06970	COG1733	regulation of RNA biosynthetic process
J4048_06975	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_06985	COG1388	LysM domain
J4048_06985	COG4641	Protein conserved in bacteria
J4048_06990	COG1388	LysM domain
J4048_06995	COG3858	chitin binding
J4048_07005	COG4873	Protein conserved in bacteria
J4048_07015	COG3773	Cell wall hydrolase
J4048_07020	COG2244	polysaccharide biosynthetic process
J4048_07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_07030	COG2217	Heavy metal translocating P-type atpase
J4048_07035	COG0006	proline dipeptidase activity
J4048_07040	COG1609	Transcriptional regulator
J4048_07045	COG3711	transcriptional antiterminator
J4048_07050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_07050	COG2190	(PTS) system
J4048_07050	COG1263	PTS System
J4048_07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_07060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4048_07070	COG1533	DNA photolyase activity
J4048_07075	COG0840	transmembrane signaling receptor activity
J4048_07080	COG2084	Dehydrogenase
J4048_07085	COG2340	Cysteine-rich secretory protein family
J4048_07090	COG0768	penicillin binding
J4048_07095	COG4191	Histidine kinase
J4048_07100	COG0436	Aminotransferase
J4048_07110	COG0784	Response regulator, receiver
J4048_07110	COG0835	chemotaxis
J4048_07125	COG2814	Major facilitator Superfamily
J4048_07130	COG1376	ErfK ybiS ycfS ynhG family protein
J4048_07135	COG1408	metallophosphoesterase
J4048_07140	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_07150	COG2200	EAL domain
J4048_07155	COG4703	Protein of unknown function (DUF1797)
J4048_07160	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
J4048_07170	COG0517	IMP dehydrogenase activity
J4048_07175	COG0583	DNA-binding transcription factor activity
J4048_07180	COG0716	FMN binding
J4048_07190	COG0716	FMN binding
J4048_07210	COG0668	transmembrane transport
J4048_07215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_07235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4048_07240	COG0303	'Molybdopterin
J4048_07245	COG1763	Mo-molybdopterin cofactor biosynthetic process
J4048_07250	COG0314	molybdopterin synthase activity
J4048_07255	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J4048_07265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J4048_07270	COG1136	(ABC) transporter
J4048_07275	COG0577	efflux transmembrane transporter activity
J4048_07280	COG1349	DNA-binding transcription factor activity
J4048_07285	COG1105	Belongs to the carbohydrate kinase PfkB family
J4048_07290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4048_07290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4048_07290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_07295	COG0681	Belongs to the peptidase S26 family
J4048_07305	COG0488	(ABC) transporter
J4048_07310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4048_07315	COG2309	aminopeptidase activity
J4048_07325	COG1077	Cell shape determining protein MreB Mrl
J4048_07330	COG2002	toxin-antitoxin pair type II binding
J4048_07335	COG3852	Histidine kinase
J4048_07340	COG2105	PFAM AIG2 family protein
J4048_07340	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
J4048_07345	COG0569	domain protein
J4048_07355	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J4048_07365	COG0561	phosphatase activity
J4048_07370	COG0242	peptide deformylase activity
J4048_07380	COG0497	DNA recombination
J4048_07390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_07390	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_07390	COG3321	synthase
J4048_07390	COG4221	oxidoreductase activity
J4048_07395	COG0300	oxidoreductase activity
J4048_07395	COG3321	synthase
J4048_07395	COG4221	oxidoreductase activity
J4048_07395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_07405	COG3321	synthase
J4048_07405	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_07405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_07405	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_07405	COG0300	oxidoreductase activity
J4048_07410	COG0300	oxidoreductase activity
J4048_07410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_07410	COG3321	synthase
J4048_07410	COG4221	oxidoreductase activity
J4048_07415	COG0300	oxidoreductase activity
J4048_07415	COG4221	oxidoreductase activity
J4048_07415	COG3321	synthase
J4048_07415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_07420	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_07420	COG4221	oxidoreductase activity
J4048_07420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_07420	COG3321	synthase
J4048_07425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4048_07430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4048_07435	COG0022	dehydrogenase e1 component
J4048_07440	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4048_07445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4048_07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_07465	COG1982	Orn Lys Arg decarboxylase major
J4048_07485	COG0483	inositol monophosphate 1-phosphatase activity
J4048_07495	COG3227	Zinc metalloprotease (Elastase)
J4048_07530	COG1217	gtp-binding protein TYPA
J4048_07540	COG4896	Protein conserved in bacteria
J4048_07550	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
J4048_07555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J4048_07560	COG2066	Belongs to the glutaminase family
J4048_07570	COG0772	Belongs to the SEDS family
J4048_07575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J4048_07590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4048_07590	COG2010	Cytochrome c
J4048_07595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4048_07600	COG1845	cytochrome c oxidase, subunit III
J4048_07605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J4048_07610	COG3336	cytochrome c oxidase
J4048_07620	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
J4048_07625	COG2340	Cysteine-rich secretory protein family
J4048_07640	COG3679	Belongs to the UPF0342 family
J4048_07650	COG0742	ribosomal rna small subunit methyltransferase
J4048_07660	COG3314	Sporulation integral membrane protein YlbJ
J4048_07665	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4048_07670	COG3480	Lon protease (S16) C-terminal proteolytic domain
J4048_07680	COG1399	metal-binding, possibly nucleic acid-binding protein
J4048_07700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
J4048_07720	COG4839	cell division protein FtsL
J4048_07725	COG0768	penicillin binding
J4048_07730	COG0768	penicillin binding
J4048_07750	COG0772	Belongs to the SEDS family
J4048_07765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4048_07770	COG0849	cell division
J4048_07775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4048_07780	COG1404	Belongs to the peptidase S8 family
J4048_07780	COG4412	M6 family metalloprotease domain protein
J4048_07790	COG1191	sigma factor activity
J4048_07795	COG1191	sigma factor activity
J4048_07800	COG1119	ATPase activity
J4048_07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4048_07810	COG1873	PFAM PRC-barrel domain
J4048_07815	COG1496	oxidoreductase activity
J4048_07820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4048_07830	COG0762	integral membrane protein
J4048_07835	COG2302	S4 RNA-binding domain
J4048_07840	COG3599	regulation of cell shape
J4048_07845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4048_07850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4048_07860	COG0564	pseudouridine synthase activity
J4048_07870	COG2233	PERMEase
J4048_07880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4048_07885	COG0505	Belongs to the CarA family
J4048_07890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4048_07905	COG0284	orotidine-5'-phosphate decarboxylase activity
J4048_07910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J4048_07920	COG0306	phosphate transporter
J4048_07935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J4048_07940	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
J4048_07945	COG1648	precorrin-2 dehydrogenase activity
J4048_07955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4048_07960	COG1561	YicC-like family, N-terminal region
J4048_07970	COG0194	GDP metabolic process
J4048_07980	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4048_07985	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4048_07990	COG0242	peptide deformylase activity
J4048_08000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4048_08000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4048_08010	COG0631	protein serine/threonine phosphatase activity
J4048_08015	COG0515	serine threonine protein kinase
J4048_08015	COG2815	serine threonine protein kinase
J4048_08025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4048_08030	COG1564	THIamine pyrophosphokinase
J4048_08045	COG1302	Protein conserved in bacteria
J4048_08050	COG1461	Dihydroxyacetone kinase
J4048_08055	COG1760	l-serine dehydratase
J4048_08060	COG1760	l-serine dehydratase
J4048_08065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4048_08080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J4048_08085	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_08100	COG1196	nuclear chromosome segregation
J4048_08105	COG0552	protein localization to endoplasmic reticulum
J4048_08120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4048_08130	COG1837	Belongs to the UPF0109 family
J4048_08155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4048_08170	COG2257	FlhB HrpN YscU SpaS Family
J4048_08180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J4048_08185	COG0758	DNA mediated transformation
J4048_08190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4048_08200	COG4974	Belongs to the 'phage' integrase family
J4048_08220	COG1815	bacterial-type flagellum-dependent cell motility
J4048_08225	COG1558	bacterial-type flagellum-dependent cell motility
J4048_08230	COG1677	Flagellar hook-basal body complex protein FliE
J4048_08235	COG1766	The M ring may be actively involved in energy transduction
J4048_08240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J4048_08245	COG1317	bacterial-type flagellum organization
J4048_08250	COG1157	protein secretion by the type III secretion system
J4048_08255	COG2882	bacterial-type flagellum organization
J4048_08260	COG3334	PFAM MgtE intracellular
J4048_08265	COG3144	bacterial-type flagellum assembly
J4048_08270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
J4048_08275	COG4786	Flagellar basal body rod
J4048_08280	COG1582	Flagellar protein (FlbD)
J4048_08285	COG1580	Controls the rotational direction of flagella during chemotaxis
J4048_08290	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J4048_08295	COG1776	CheC inhibitor of MCP methylation
J4048_08295	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J4048_08300	COG2201	protein-glutamate methylesterase activity
J4048_08305	COG3190	flagellar
J4048_08310	COG1338	Plays a role in the flagellum-specific transport system
J4048_08315	COG1987	bacterial-type flagellum assembly
J4048_08320	COG1684	flagellar biosynthetic protein fliR
J4048_08325	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J4048_08330	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J4048_08335	COG1419	protein localization to endoplasmic reticulum
J4048_08340	COG0455	bacterial-type flagellum organization
J4048_08345	COG2201	protein-glutamate methylesterase activity
J4048_08350	COG0643	Histidine kinase
J4048_08350	COG2198	Histidine kinase
J4048_08355	COG0835	chemotaxis
J4048_08360	COG1776	CheC inhibitor of MCP methylation
J4048_08370	COG1191	sigma factor activity
J4048_08400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4048_08405	COG4589	Belongs to the CDS family
J4048_08415	COG0750	zinc metalloprotease
J4048_08425	COG2176	DNA-directed DNA polymerase activity
J4048_08435	COG0195	Participates in both transcription termination and antitermination
J4048_08440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
J4048_08445	COG1358	cellular component organization or biogenesis
J4048_08455	COG1550	Protein conserved in bacteria
J4048_08470	COG0196	riboflavin kinase activity
J4048_08485	COG0726	polysaccharide deacetylase
J4048_08490	COG0612	Peptidase, M16
J4048_08495	COG1873	PFAM PRC-barrel domain
J4048_08500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4048_08505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4048_08510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4048_08515	COG0527	aspartate kinase activity
J4048_08525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J4048_08530	COG0740	serine-type endopeptidase activity
J4048_08540	COG1674	ftsk spoiiie
J4048_08540	COG4980	gas vesicle protein
J4048_08545	COG2188	Transcriptional regulator
J4048_08550	COG2814	Major facilitator Superfamily
J4048_08555	COG1846	Transcriptional regulator
J4048_08560	COG1033	growth of symbiont in host cell
J4048_08560	COG2409	Drug exporters of the RND superfamily
J4048_08565	COG0612	Peptidase, M16
J4048_08570	COG0612	Peptidase, M16
J4048_08575	COG0300	oxidoreductase activity
J4048_08590	COG1426	Protein conserved in bacteria
J4048_08595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4048_08610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4048_08620	COG1692	metallophosphoesterase
J4048_08625	COG2359	stage V sporulation protein S
J4048_08645	COG4550	Control of competence regulator ComK, YlbF/YmcA
J4048_08665	COG0582	viral genome integration into host DNA
J4048_08705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_08710	COG3425	synthase
J4048_08715	COG1024	Enoyl-CoA hydratase
J4048_08720	COG1024	Enoyl-CoA hydratase
J4048_08725	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_08725	COG3321	synthase
J4048_08725	COG0300	oxidoreductase activity
J4048_08725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_08725	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_08730	COG0300	oxidoreductase activity
J4048_08730	COG3321	synthase
J4048_08730	COG4221	oxidoreductase activity
J4048_08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_08735	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_08735	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_08735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_08735	COG3321	synthase
J4048_08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_08735	COG3321	synthase
J4048_08735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_08740	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_08740	COG3321	synthase
J4048_08740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_08740	COG4221	oxidoreductase activity
J4048_08745	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
J4048_08745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J4048_08745	COG3321	synthase
J4048_08745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_08750	COG2124	cytochrome p450
J4048_08755	COG3209	COG3209 Rhs family protein
J4048_08760	COG3619	membrane
J4048_08770	COG1404	Belongs to the peptidase S8 family
J4048_08780	COG4195	phage-related replication protein
J4048_08785	COG1764	response to oxidative stress
J4048_08795	COG2076	Multidrug Resistance protein
J4048_08835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4048_08840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4048_08845	COG4112	unkown
J4048_08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_08855	COG0464	growth
J4048_08860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4048_08865	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
J4048_08870	COG0789	Transcriptional regulator
J4048_08875	COG0174	glutamine synthetase
J4048_08885	COG4282	regulation of fungal-type cell wall biogenesis
J4048_08910	COG2211	Major facilitator Superfamily
J4048_08915	COG3507	Belongs to the glycosyl hydrolase 43 family
J4048_08930	COG1070	Carbohydrate kinase
J4048_08935	COG0574	Belongs to the PEP-utilizing enzyme family
J4048_08935	COG3848	Pyruvate phosphate dikinase
J4048_08955	COG1064	alcohol dehydrogenase
J4048_08975	COG0456	acetyltransferase
J4048_08995	COG3397	chitin binding
J4048_09005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_09020	COG5434	Belongs to the glycosyl hydrolase 28 family
J4048_09025	COG0756	dUTP diphosphatase activity
J4048_09035	COG4195	phage-related replication protein
J4048_09070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J4048_09080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J4048_09100	COG0785	Cytochrome C biogenesis protein
J4048_09105	COG2201	protein-glutamate methylesterase activity
J4048_09110	COG4846	Membrane protein involved in cytochrome C biogenesis
J4048_09120	COG0071	Belongs to the small heat shock protein (HSP20) family
J4048_09135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4048_09140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_09160	COG0824	Thioesterase
J4048_09170	COG4841	protein insertion into membrane
J4048_09180	COG1832	CoA-binding protein
J4048_09185	COG0187	DNA topoisomerase II activity
J4048_09190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4048_09200	COG1115	amino acid carrier protein
J4048_09210	COG1063	alcohol dehydrogenase
J4048_09215	COG0800	Aldolase
J4048_09220	COG1312	Catalyzes the dehydration of D-mannonate
J4048_09225	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_09230	COG1609	Transcriptional regulator
J4048_09235	COG2271	Major facilitator Superfamily
J4048_09275	COG0457	Tetratricopeptide repeat
J4048_09305	COG1136	(ABC) transporter
J4048_09305	COG0577	efflux transmembrane transporter activity
J4048_09335	COG2205	protein histidine kinase activity
J4048_09340	COG0745	RESPONSE REGULATOR receiver
J4048_09350	COG3507	Belongs to the glycosyl hydrolase 43 family
J4048_09375	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_09380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J4048_09385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J4048_09390	COG2610	gluconate transmembrane transporter activity
J4048_09395	COG2124	cytochrome p450
J4048_09415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J4048_09425	COG2246	polysaccharide biosynthetic process
J4048_09430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4048_09435	COG0586	Pfam SNARE associated Golgi protein
J4048_09440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J4048_09445	COG1024	Enoyl-CoA hydratase
J4048_09450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4048_09455	COG0511	ligase activity, forming carbon-carbon bonds
J4048_09460	COG0439	Biotin carboxylase
J4048_09465	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_09470	COG1960	acyl-CoA dehydrogenase activity
J4048_09475	COG1649	PFAM Uncharacterised BCR, COG1649
J4048_09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_09485	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
J4048_09490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_09495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_09500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_09515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_09520	COG2027	D-alanyl-D-alanine carboxypeptidase
J4048_09525	COG2017	converts alpha-aldose to the beta-anomer
J4048_09530	COG0534	Mate efflux family protein
J4048_09545	COG0582	viral genome integration into host DNA
J4048_09550	COG0166	Belongs to the GPI family
J4048_09555	COG0405	Gamma-glutamyltransferase
J4048_09560	COG2814	Major facilitator Superfamily
J4048_09565	COG0640	Transcriptional regulator
J4048_09570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J4048_09580	COG0604	alcohol dehydrogenase
J4048_09585	COG0493	'glutamate synthase
J4048_09590	COG0067	glutamate synthase
J4048_09590	COG0069	glutamate synthase activity
J4048_09590	COG0070	glutamate synthase
J4048_09595	COG0583	DNA-binding transcription factor activity
J4048_09600	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4048_09615	COG0300	oxidoreductase activity
J4048_09620	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
J4048_09630	COG2814	Major facilitator Superfamily
J4048_09635	COG1070	Carbohydrate kinase
J4048_09640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4048_09645	COG0243	molybdopterin cofactor binding
J4048_09670	COG5444	nuclease activity
J4048_09675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4048_09680	COG2207	Transcriptional regulator
J4048_09680	COG0662	Cupin 2, conserved barrel domain protein
J4048_09685	COG1309	transcriptional regulator
J4048_09690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_09700	COG0640	Transcriptional regulator
J4048_09705	COG0741	lytic transglycosylase activity
J4048_09710	COG2322	membrane
J4048_09725	COG1619	proteins homologs of microcin C7 resistance protein MccF
J4048_09735	COG3584	3D domain protein
J4048_09735	COG1388	LysM domain
J4048_09740	COG0514	ATP-dependent DNA helicase (RecQ)
J4048_09750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J4048_09755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4048_09770	COG0071	Belongs to the small heat shock protein (HSP20) family
J4048_09800	COG1012	belongs to the aldehyde dehydrogenase family
J4048_09810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4048_09815	COG0733	neurotransmitter:sodium symporter activity
J4048_09820	COG0385	Bile acid
J4048_09825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_09830	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4048_09840	COG4548	von Willebrand factor, type A
J4048_09845	COG0714	Associated with various cellular activities
J4048_09850	COG2032	superoxide dismutase activity
J4048_09855	COG1388	LysM domain
J4048_09855	COG0791	NLP P60 protein
J4048_09860	COG1819	glycosyl
J4048_09865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J4048_09870	COG0534	Mate efflux family protein
J4048_09875	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_09880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J4048_09885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J4048_09895	COG2962	Rard protein
J4048_09910	COG1942	4-Oxalocrotonate Tautomerase
J4048_09920	COG1733	regulation of RNA biosynthetic process
J4048_09925	COG0778	Nitroreductase
J4048_09930	COG0400	carboxylic ester hydrolase activity
J4048_09935	COG0346	lactoylglutathione lyase activity
J4048_09945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4048_09955	COG2723	6-phospho-beta-galactosidase activity
J4048_09960	COG2188	Transcriptional regulator
J4048_09965	COG0793	Belongs to the peptidase S41A family
J4048_09965	COG3409	Peptidoglycan-binding domain 1 protein
J4048_09970	COG2226	methyltransferase
J4048_09980	COG1876	peptidase activity
J4048_10000	COG0671	phosphoesterase, PA-phosphatase related
J4048_10035	COG1509	lysine 2,3-aminomutase activity
J4048_10040	COG0456	acetyltransferase
J4048_10045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4048_10050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J4048_10055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J4048_10060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J4048_10065	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
J4048_10075	COG0456	acetyltransferase
J4048_10080	COG0463	Glycosyl transferase, family 2
J4048_10095	COG4641	Protein conserved in bacteria
J4048_10105	COG1086	Polysaccharide biosynthesis protein
J4048_10150	COG1388	LysM domain
J4048_10155	COG0457	Tetratricopeptide repeat
J4048_10175	COG5444	nuclease activity
J4048_10180	COG4282	regulation of fungal-type cell wall biogenesis
J4048_10185	COG1525	nuclease
J4048_10190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J4048_10210	COG1846	Transcriptional regulator
J4048_10215	COG4698	Protein conserved in bacteria
J4048_10220	COG2755	lipolytic protein G-D-S-L family
J4048_10225	COG1999	signal sequence binding
J4048_10235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4048_10240	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
J4048_10245	COG1272	protein, Hemolysin III
J4048_10255	COG0204	Acyl-transferase
J4048_10260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J4048_10275	COG2136	Putative SAM-dependent methyltransferase
J4048_10275	COG2521	methyltransferase
J4048_10290	COG1413	lyase activity
J4048_10300	COG0386	Belongs to the glutathione peroxidase family
J4048_10310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4048_10320	COG1278	Cold shock
J4048_10340	COG0328	RNA-DNA hybrid ribonuclease activity
J4048_10345	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J4048_10350	COG0328	RNA-DNA hybrid ribonuclease activity
J4048_10360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4048_10375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
J4048_10385	COG1755	Isoprenylcysteine carboxyl methyltransferase
J4048_10390	COG3424	synthase
J4048_10415	COG1335	isochorismatase
J4048_10435	COG3331	DNA recombination
J4048_10485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J4048_10520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J4048_10525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J4048_10540	COG4112	unkown
J4048_10555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_10560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4048_10570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4048_10570	COG1372	Participates in initiation and elongation during chromosome replication
J4048_10575	COG1780	Probably involved in ribonucleotide reductase function
J4048_10640	COG0270	DNA (cytosine-5-)-methyltransferase activity
J4048_10655	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
J4048_10660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4048_10675	COG3584	3D domain protein
J4048_10680	COG0587	DNA-directed DNA polymerase activity
J4048_10685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4048_10690	COG0358	DNA primase activity
J4048_10695	COG0305	Participates in initiation and elongation during chromosome replication
J4048_10705	COG2887	Belongs to the helicase family. UvrD subfamily
J4048_10725	COG5434	Belongs to the glycosyl hydrolase 28 family
J4048_10725	COG3420	alginic acid biosynthetic process
J4048_10730	COG4195	phage-related replication protein
J4048_10760	COG2135	peptidase activity
J4048_10765	COG1793	dna ligase
J4048_10870	COG3655	Transcriptional regulator
J4048_10990	COG3655	Transcriptional regulator
J4048_10995	COG3655	Transcriptional regulator
J4048_11075	COG0776	regulation of translation
J4048_11225	COG1196	nuclear chromosome segregation
J4048_11225	COG0741	lytic transglycosylase activity
J4048_11225	COG0739	heme binding
J4048_11235	COG2433	Pfam Transposase IS66
J4048_11245	COG5434	Belongs to the glycosyl hydrolase 28 family
J4048_11250	COG3409	Peptidoglycan-binding domain 1 protein
J4048_11250	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4048_11270	COG0457	Tetratricopeptide repeat
J4048_11275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4048_11315	COG5444	nuclease activity
J4048_11320	COG1525	nuclease
J4048_11340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
J4048_11345	COG1199	ATP-dependent helicase activity
J4048_11360	COG0116	Belongs to the methyltransferase superfamily
J4048_11390	COG3359	exonuclease
J4048_11395	COG1111	helicase
J4048_11395	COG1205	dead DEAH box helicase
J4048_11400	COG2190	(PTS) system
J4048_11405	COG0071	Belongs to the small heat shock protein (HSP20) family
J4048_11445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4048_11445	COG4499	WXG100 protein secretion system (Wss), protein YukC
J4048_11455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4048_11460	COG3935	DnaD domain protein
J4048_11470	COG0436	Aminotransferase
J4048_11475	COG5353	protein conserved in bacteria
J4048_11485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4048_11485	COG1199	ATP-dependent helicase activity
J4048_11515	COG0438	transferase activity, transferring glycosyl groups
J4048_11520	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J4048_11535	COG1694	Mazg nucleotide pyrophosphohydrolase
J4048_11540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_11545	COG2140	Oxalate decarboxylase
J4048_11555	COG4347	Protein of unknown function (DUF1405)
J4048_11560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J4048_11560	COG2010	Cytochrome c
J4048_11565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J4048_11570	COG0723	plastoquinol--plastocyanin reductase activity
J4048_11585	COG0457	Tetratricopeptide repeat
J4048_11595	COG0287	Prephenate dehydrogenase
J4048_11630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J4048_11635	COG4401	Chorismate mutase type I
J4048_11650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J4048_11655	COG0105	UTP biosynthetic process
J4048_11660	COG0142	geranyltranstransferase activity
J4048_11670	COG0142	geranyltranstransferase activity
J4048_11685	COG0776	regulation of translation
J4048_11690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
J4048_11730	COG0539	negative regulation of cytoplasmic translation
J4048_11745	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
J4048_11750	COG2959	enzyme of heme biosynthesis
J4048_11755	COG3409	Peptidoglycan-binding domain 1 protein
J4048_11755	COG3773	Cell wall hydrolase
J4048_11760	COG2339	peptidase activity
J4048_11765	COG0492	ferredoxin-NADP+ reductase activity
J4048_11770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4048_11775	COG4862	establishment of competence for transformation
J4048_11780	COG1408	metallophosphoesterase
J4048_11790	COG1388	LysM domain
J4048_11795	COG1266	CAAX protease self-immunity
J4048_11800	COG0514	ATP-dependent DNA helicase (RecQ)
J4048_11805	COG4955	Helix-turn-helix domain
J4048_11810	COG1141	Ferredoxin
J4048_11815	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
J4048_11820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4048_11830	COG1595	DNA-templated transcription, initiation
J4048_11835	COG5002	protein histidine kinase activity
J4048_11840	COG0745	RESPONSE REGULATOR receiver
J4048_11845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4048_11850	COG1333	cytochrome c biogenesis protein
J4048_11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_11860	COG1187	pseudouridine synthase activity
J4048_11865	COG0700	Nucleoside recognition
J4048_11870	COG2715	membrane protein required for spore maturation
J4048_11875	COG1686	Belongs to the peptidase S11 family
J4048_11900	COG1547	Domain of unknown function (DUF309)
J4048_11905	COG0456	acetyltransferase
J4048_11920	COG0307	riboflavin synthase, alpha
J4048_11925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4048_11925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J4048_11935	COG0681	Belongs to the peptidase S26 family
J4048_11945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4048_11950	COG4086	secreted protein
J4048_11955	COG0019	diaminopimelate decarboxylase activity
J4048_11960	COG0697	spore germination
J4048_11975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4048_11995	COG1191	sigma factor activity
J4048_12005	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_12010	COG1686	Belongs to the peptidase S11 family
J4048_12015	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J4048_12020	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J4048_12025	COG4974	Belongs to the 'phage' integrase family
J4048_12035	COG0735	belongs to the Fur family
J4048_12040	COG1300	Membrane
J4048_12055	COG0281	malic enzyme
J4048_12060	COG1757	Na H antiporter
J4048_12065	COG1027	Aspartate ammonia-lyase
J4048_12070	COG0252	asparaginase activity
J4048_12075	COG1396	sequence-specific DNA binding
J4048_12080	COG1379	DNA repair
J4048_12085	COG0494	nUDIX hydrolase
J4048_12095	COG0667	Aldo Keto reductase
J4048_12105	COG1073	alpha beta
J4048_12115	COG4918	Iron-sulphur cluster biosynthesis
J4048_12120	COG0456	acetyltransferase
J4048_12120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J4048_12125	COG2329	Antibiotic biosynthesis monooxygenase
J4048_12130	COG0456	acetyltransferase
J4048_12135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4048_12150	COG0628	permease
J4048_12160	COG0346	lactoylglutathione lyase activity
J4048_12170	COG3048	D-serine ammonia-lyase activity
J4048_12175	COG0300	oxidoreductase activity
J4048_12180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_12185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4048_12190	COG1024	Enoyl-CoA hydratase
J4048_12195	COG3425	synthase
J4048_12200	COG2124	cytochrome p450
J4048_12205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_12205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_12205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12205	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12205	COG3321	synthase
J4048_12210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12210	COG3321	synthase
J4048_12210	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_12210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_12215	COG0300	oxidoreductase activity
J4048_12215	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_12215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12215	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12215	COG3321	synthase
J4048_12220	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_12220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12220	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12220	COG3321	synthase
J4048_12220	COG0300	oxidoreductase activity
J4048_12225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_12225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12225	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12225	COG3321	synthase
J4048_12225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_12230	COG0300	oxidoreductase activity
J4048_12230	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_12230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12230	COG3321	synthase
J4048_12230	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12235	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12235	COG3321	synthase
J4048_12235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_12235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_12235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4048_12240	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_12245	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_12260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J4048_12260	COG2070	2-Nitropropane dioxygenase
J4048_12265	COG0250	Participates in transcription elongation, termination and antitermination
J4048_12285	COG0596	Alpha beta hydrolase
J4048_12300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J4048_12305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J4048_12320	COG0706	membrane insertase activity
J4048_12325	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4048_12330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J4048_12335	COG0346	lactoylglutathione lyase activity
J4048_12345	COG1376	ErfK ybiS ycfS ynhG family protein
J4048_12350	COG4129	membrane
J4048_12355	COG1126	abc transporter atp-binding protein
J4048_12360	COG0765	amino acid transport
J4048_12365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_12375	COG1597	lipid kinase activity
J4048_12380	COG0508	dehydrogenase complex catalyzes the overall conversion of
J4048_12385	COG0022	dehydrogenase e1 component
J4048_12390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J4048_12395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4048_12400	COG3426	butyrate kinase activity
J4048_12405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4048_12410	COG0280	phosphate acetyltransferase
J4048_12415	COG3290	protein histidine kinase activity
J4048_12415	COG3829	transcription factor binding
J4048_12425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
J4048_12430	COG2079	MmgE PrpD family protein
J4048_12435	COG0372	Belongs to the citrate synthase family
J4048_12440	COG1960	acyl-CoA dehydrogenase activity
J4048_12445	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4048_12450	COG0183	Belongs to the thiolase family
J4048_12455	COG0584	glycerophosphoryl diester phosphodiesterase
J4048_12460	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_12485	COG1902	pentaerythritol trinitrate reductase activity
J4048_12500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4048_12505	COG0745	RESPONSE REGULATOR receiver
J4048_12510	COG0750	zinc metalloprotease
J4048_12515	COG0497	DNA recombination
J4048_12525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J4048_12535	COG0142	geranyltranstransferase activity
J4048_12545	COG1570	exodeoxyribonuclease VII activity
J4048_12560	COG1302	Protein conserved in bacteria
J4048_12565	COG0439	Biotin carboxylase
J4048_12570	COG0511	ligase activity, forming carbon-carbon bonds
J4048_12610	COG3854	ATPases associated with a variety of cellular activities
J4048_12625	COG0006	proline dipeptidase activity
J4048_12635	COG3872	metal-dependent enzyme
J4048_12645	COG1752	Esterase of the alpha-beta hydrolase superfamily
J4048_12660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4048_12680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4048_12695	COG1396	sequence-specific DNA binding
J4048_12705	COG0681	Belongs to the peptidase S26 family
J4048_12730	COG4940	Competence protein ComGF
J4048_12740	COG4970	Tfp pilus assembly protein FimT
J4048_12745	COG4537	Required for transformation and DNA binding
J4048_12750	COG1459	type II secretion system
J4048_12755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4048_12760	COG0598	Magnesium transport protein CorA
J4048_12765	COG1253	flavin adenine dinucleotide binding
J4048_12770	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_12780	COG1393	Belongs to the ArsC family
J4048_12790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_12800	COG0011	TIGRFAM Protein of
J4048_12810	COG2866	Carboxypeptidase
J4048_12815	COG1940	carbohydrate kinase activity
J4048_12820	COG4483	Protein conserved in bacteria
J4048_12825	COG1757	Na H antiporter
J4048_12835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4048_12850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4048_12855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4048_12860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4048_12865	COG0581	inorganic phosphate transmembrane transporter activity
J4048_12870	COG0573	inorganic phosphate transmembrane transporter activity
J4048_12875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J4048_12880	COG0768	penicillin binding
J4048_12885	COG0477	Major facilitator Superfamily
J4048_12890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4048_12895	COG2839	Protein conserved in bacteria
J4048_12900	COG5521	maltodextrose utilization protein MalA
J4048_12905	COG1388	LysM domain
J4048_12915	COG4709	membrane
J4048_12920	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
J4048_12925	COG0735	belongs to the Fur family
J4048_12930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_12945	COG0513	Belongs to the DEAD box helicase family
J4048_12960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4048_12965	COG2384	SAM-dependent methyltransferase
J4048_12970	COG2010	Cytochrome c
J4048_12975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4048_12980	COG0358	DNA primase activity
J4048_12995	COG0517	IMP dehydrogenase activity
J4048_13000	COG0751	glycine-tRNA ligase activity
J4048_13020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J4048_13025	COG0295	cytidine deaminase activity
J4048_13030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4048_13040	COG1480	7TM receptor with intracellular HD hydrolase
J4048_13045	COG1702	phosphate starvation-inducible protein PhoH
J4048_13050	COG0561	phosphatase activity
J4048_13065	COG4864	UPF0365 protein
J4048_13070	COG1030	water channel activity
J4048_13075	COG1610	YqeY-like protein
J4048_13085	COG1283	sodium-dependent phosphate transmembrane transporter activity
J4048_13090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4048_13095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4048_13125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4048_13140	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_13155	COG1466	dna polymerase III delta subunit
J4048_13170	COG0658	competence protein
J4048_13170	COG2333	competence protein COMEC
J4048_13175	COG2131	deaminase
J4048_13180	COG1555	photosystem II stabilization
J4048_13180	COG1596	polysaccharide export
J4048_13185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4048_13190	COG2226	methyltransferase
J4048_13195	COG0799	negative regulation of ribosome biogenesis
J4048_13200	COG1713	HD superfamily hydrolase involved in NAD metabolism
J4048_13210	COG1534	Rna-binding protein
J4048_13215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4048_13220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4048_13225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J4048_13235	COG2755	lipolytic protein G-D-S-L family
J4048_13245	COG0398	Pfam SNARE associated Golgi protein
J4048_13270	COG1794	racemase activity, acting on amino acids and derivatives
J4048_13285	COG0656	L-ascorbic acid biosynthetic process
J4048_13320	COG0642	Histidine kinase
J4048_13320	COG5002	protein histidine kinase activity
J4048_13325	COG0745	RESPONSE REGULATOR receiver
J4048_13330	COG2311	Membrane
J4048_13340	COG0454	-acetyltransferase
J4048_13345	COG0563	adenylate kinase activity
J4048_13355	COG2814	Major facilitator Superfamily
J4048_13365	COG0456	acetyltransferase
J4048_13370	COG2318	DinB family
J4048_13380	COG0561	phosphatase activity
J4048_13385	COG0561	phosphatase activity
J4048_13395	COG1482	cell wall glycoprotein biosynthetic process
J4048_13400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_13400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4048_13400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4048_13405	COG3711	transcriptional antiterminator
J4048_13405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_13415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4048_13420	COG0583	DNA-binding transcription factor activity
J4048_13425	COG2814	Major facilitator Superfamily
J4048_13430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4048_13430	COG2124	cytochrome p450
J4048_13435	COG1309	transcriptional regulator
J4048_13440	COG2226	methyltransferase
J4048_13455	COG2116	formate transmembrane transporter activity
J4048_13460	COG5609	conserved protein (DUF2294)
J4048_13465	COG3383	formate dehydrogenase (NAD+) activity
J4048_13470	COG2427	Protein of unknown function (DUF1641)
J4048_13480	COG0626	cystathionine gamma-synthase activity
J4048_13485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4048_13510	COG0768	penicillin binding
J4048_13525	COG0826	peptidase U32
J4048_13530	COG0826	peptidase U32
J4048_13535	COG4122	O-methyltransferase activity
J4048_13540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4048_13555	COG4472	Bacterial protein of unknown function (DUF965)
J4048_13565	COG0628	permease
J4048_13570	COG1126	abc transporter atp-binding protein
J4048_13575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_13580	COG0765	amino acid transport
J4048_13585	COG0765	amino acid transport
J4048_13600	COG3881	PFAM PRC-barrel domain
J4048_13605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4048_13610	COG0457	Tetratricopeptide repeat
J4048_13620	COG1104	cysteine desulfurase activity
J4048_13625	COG1959	2 iron, 2 sulfur cluster binding
J4048_13630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4048_13635	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4048_13660	COG4991	sh3 domain protein
J4048_13660	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_13660	COG3103	Sh3 type 3 domain protein
J4048_13670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4048_13680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4048_13680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J4048_13685	COG5416	Lipopolysaccharide assembly protein A domain
J4048_13690	COG0490	domain, Protein
J4048_13695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4048_13695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4048_13705	COG2244	polysaccharide biosynthetic process
J4048_13710	COG2323	membrane
J4048_13720	COG1862	Preprotein translocase
J4048_13765	COG1388	LysM domain
J4048_13775	COG0157	Belongs to the NadC ModD family
J4048_13780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J4048_13785	COG1104	cysteine desulfurase activity
J4048_13790	COG1827	regulation of RNA biosynthetic process
J4048_13795	COG0077	Prephenate dehydratase
J4048_13810	COG3290	protein histidine kinase activity
J4048_13815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4048_13820	COG2868	ribosomal protein
J4048_13830	COG1994	Peptidase M50
J4048_13835	COG0739	heme binding
J4048_13840	COG2894	cell division
J4048_13850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J4048_13860	COG1077	Cell shape determining protein MreB Mrl
J4048_13880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J4048_13885	COG0285	dihydrofolate synthase activity
J4048_13890	COG0525	valine-tRNA ligase activity
J4048_13900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4048_13905	COG1388	LysM domain
J4048_13915	COG0113	porphobilinogen synthase activity
J4048_13920	COG1587	Uroporphyrinogen-III synthase
J4048_13930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J4048_13950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J4048_13955	COG1067	ATP-dependent peptidase activity
J4048_13955	COG0470	DNA polymerase III
J4048_13970	COG0457	Tetratricopeptide repeat
J4048_13970	COG1477	protein flavinylation
J4048_13985	COG0473	3-isopropylmalate dehydrogenase activity
J4048_14000	COG0440	acetolactate synthase activity
J4048_14005	COG0028	Belongs to the TPP enzyme family
J4048_14025	COG0732	type I restriction modification DNA specificity domain
J4048_14035	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
J4048_14055	COG0622	Phosphoesterase
J4048_14060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4048_14070	COG5401	PFAM Sporulation and spore germination
J4048_14080	COG1846	Transcriptional regulator
J4048_14085	COG2197	response regulator
J4048_14090	COG0824	Thioesterase
J4048_14095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J4048_14100	COG1053	succinate dehydrogenase
J4048_14105	COG2009	succinate dehydrogenase
J4048_14110	COG1719	4-vinyl reductase, 4VR
J4048_14115	COG0527	aspartate kinase activity
J4048_14125	COG3118	belongs to the thioredoxin family
J4048_14130	COG3534	alpha-L-arabinofuranosidase
J4048_14135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
J4048_14140	COG2086	electron transfer activity
J4048_14145	COG1024	Enoyl-CoA hydratase
J4048_14150	COG1309	transcriptional regulator
J4048_14155	COG0318	PFAM AMP-dependent synthetase and ligase
J4048_14165	COG3766	membrane
J4048_14175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J4048_14175	COG1796	DNA polymerase
J4048_14180	COG1286	toxin biosynthetic process
J4048_14195	COG0072	phenylalanine-tRNA ligase activity
J4048_14195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4048_14200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J4048_14205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4048_14215	COG3835	regulator
J4048_14220	COG0277	FAD linked oxidase domain protein
J4048_14225	COG0247	lactate metabolic process
J4048_14230	COG1966	Carbon starvation protein
J4048_14235	COG3534	alpha-L-arabinofuranosidase
J4048_14240	COG0395	ABC-type sugar transport system, permease component
J4048_14245	COG1175	transmembrane transport
J4048_14250	COG1653	transport
J4048_14260	COG0647	UMP catabolic process
J4048_14265	COG0235	Class ii aldolase
J4048_14270	COG1069	ribulokinase activity
J4048_14275	COG2160	L-arabinose isomerase activity
J4048_14280	COG3507	Belongs to the glycosyl hydrolase 43 family
J4048_14285	COG1363	Peptidase, m42
J4048_14295	COG3326	Membrane
J4048_14300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J4048_14310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J4048_14315	COG1346	cytolysis
J4048_14320	COG1380	Effector of murein hydrolase LrgA
J4048_14325	COG3279	Response regulator of the LytR AlgR family
J4048_14330	COG3275	phosphorelay sensor kinase activity
J4048_14335	COG1011	Hydrolase
J4048_14350	COG0398	Pfam SNARE associated Golgi protein
J4048_14355	COG1484	DNA-dependent DNA replication
J4048_14360	COG3611	Membrane attachment protein
J4048_14375	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4048_14380	COG1733	regulation of RNA biosynthetic process
J4048_14385	COG2814	Major facilitator Superfamily
J4048_14390	COG0656	L-ascorbic acid biosynthetic process
J4048_14395	COG0237	dephospho-CoA kinase activity
J4048_14400	COG1971	Probably functions as a manganese efflux pump
J4048_14405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J4048_14410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4048_14410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4048_14415	COG5002	protein histidine kinase activity
J4048_14420	COG0745	RESPONSE REGULATOR receiver
J4048_14430	COG0538	isocitrate dehydrogenase activity
J4048_14435	COG0372	Belongs to the citrate synthase family
J4048_14460	COG0628	permease
J4048_14465	COG3030	protein affecting phage T7 exclusion by the F plasmid
J4048_14470	COG0469	pyruvate kinase activity
J4048_14490	COG0281	malic enzyme
J4048_14495	COG0587	DNA-directed DNA polymerase activity
J4048_14515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J4048_14525	COG4109	DRTGG domain
J4048_14535	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_14550	COG0521	Mo-molybdopterin cofactor biosynthetic process
J4048_14560	COG0827	DNA restriction-modification system
J4048_14565	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
J4048_14570	COG3874	Sporulation protein YtfJ
J4048_14580	COG1714	RDD family
J4048_14585	COG0616	signal peptide processing
J4048_14590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4048_14595	COG1574	metal-dependent hydrolase with the TIM-barrel fold
J4048_14600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4048_14615	COG1104	cysteine desulfurase activity
J4048_14620	COG1114	Component of the transport system for branched-chain amino acids
J4048_14630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
J4048_14635	COG1309	transcriptional regulator
J4048_14640	COG1956	GAF domain-containing protein
J4048_14645	COG2203	Gaf domain
J4048_14645	COG2199	diguanylate cyclase activity
J4048_14655	COG1012	belongs to the aldehyde dehydrogenase family
J4048_14660	COG4282	regulation of fungal-type cell wall biogenesis
J4048_14665	COG1017	nitric oxide dioxygenase activity
J4048_14665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4048_14675	COG0693	protein deglycase activity
J4048_14690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4048_14695	COG1378	Sugar-specific transcriptional regulator TrmB
J4048_14715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J4048_14720	COG0454	-acetyltransferase
J4048_14725	COG0517	IMP dehydrogenase activity
J4048_14730	COG0123	including yeast histone deacetylase and acetoin utilization protein
J4048_14735	COG1360	Flagellar Motor Protein
J4048_14740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J4048_14745	COG1609	Transcriptional regulator
J4048_14750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J4048_14750	COG1605	Chorismate mutase
J4048_14755	COG3118	belongs to the thioredoxin family
J4048_14760	COG4980	gas vesicle protein
J4048_14765	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
J4048_14775	COG1674	ftsk spoiiie
J4048_14780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4048_14790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_14800	COG1363	Peptidase, m42
J4048_14805	COG5584	Small secreted protein
J4048_14810	COG0281	malic enzyme
J4048_14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4048_14830	COG0510	thiamine kinase activity
J4048_14835	COG1597	lipid kinase activity
J4048_14845	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
J4048_14850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J4048_14855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4048_14860	COG2252	PERMEase
J4048_14865	COG4473	ABC transporter
J4048_14870	COG1131	(ABC) transporter
J4048_14875	COG1349	DNA-binding transcription factor activity
J4048_14880	COG1187	pseudouridine synthase activity
J4048_14885	COG2244	polysaccharide biosynthetic process
J4048_14890	COG2081	HI0933 family
J4048_14895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J4048_14905	COG1609	Transcriptional regulator
J4048_14910	COG1653	transport
J4048_14915	COG1175	transmembrane transport
J4048_14920	COG0395	ABC-type sugar transport system, permease component
J4048_14925	COG1486	melibiose metabolic process
J4048_14935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4048_14950	COG1366	Belongs to the anti-sigma-factor antagonist family
J4048_14950	COG2202	Pas domain
J4048_14955	COG2814	Major facilitator Superfamily
J4048_14960	COG5522	Integral membrane protein (intg_mem_TP0381)
J4048_14970	COG0577	efflux transmembrane transporter activity
J4048_14975	COG1136	(ABC) transporter
J4048_14980	COG2205	protein histidine kinase activity
J4048_14985	COG0745	RESPONSE REGULATOR receiver
J4048_14990	COG0577	efflux transmembrane transporter activity
J4048_14995	COG1136	(ABC) transporter
J4048_15015	COG1131	(ABC) transporter
J4048_15020	COG1725	Transcriptional regulator
J4048_15030	COG1242	4 iron, 4 sulfur cluster binding
J4048_15035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J4048_15045	COG0584	glycerophosphoryl diester phosphodiesterase
J4048_15055	COG2267	carboxylic ester hydrolase activity
J4048_15060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J4048_15065	COG1113	amino acid transport
J4048_15070	COG0367	asparagine synthase
J4048_15090	COG1506	peptidase
J4048_15095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4048_15100	COG1116	anion transmembrane transporter activity
J4048_15105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4048_15110	COG0494	nUDIX hydrolase
J4048_15115	COG4824	toxin secretion phage lysis holin
J4048_15120	COG0783	Belongs to the Dps family
J4048_15145	COG0288	reversible hydration of carbon dioxide
J4048_15155	COG1271	oxidase subunit
J4048_15160	COG1294	oxidase, subunit
J4048_15170	COG4948	Mandelate Racemase Muconate Lactonizing
J4048_15180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J4048_15185	COG0596	Alpha beta hydrolase
J4048_15195	COG1169	isochorismate synthase
J4048_15200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J4048_15205	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
J4048_15330	COG3859	Proton-coupled thiamine transporter YuaJ
J4048_15335	COG2268	Band 7 protein
J4048_15340	COG1585	Membrane protein implicated in regulation of membrane protease activity
J4048_15345	COG2318	DinB family
J4048_15355	COG1454	alcohol dehydrogenase
J4048_15360	COG1012	belongs to the aldehyde dehydrogenase family
J4048_15365	COG1510	regulation of RNA biosynthetic process
J4048_15375	COG0569	domain protein
J4048_15380	COG1705	Flagellar rod assembly protein muramidase FlgJ
J4048_15385	COG1017	nitric oxide dioxygenase activity
J4048_15385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J4048_15410	COG0628	permease
J4048_15415	COG0673	inositol 2-dehydrogenase activity
J4048_15420	COG0693	protein deglycase activity
J4048_15425	COG0840	transmembrane signaling receptor activity
J4048_15430	COG0840	transmembrane signaling receptor activity
J4048_15435	COG0840	transmembrane signaling receptor activity
J4048_15440	COG0840	transmembrane signaling receptor activity
J4048_15455	COG2070	2-Nitropropane dioxygenase
J4048_15460	COG0432	Pfam Uncharacterised protein family UPF0047
J4048_15465	COG0366	Alpha amylase catalytic
J4048_15470	COG1253	flavin adenine dinucleotide binding
J4048_15475	COG2738	Putative neutral zinc metallopeptidase
J4048_15490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J4048_15515	COG1335	isochorismatase
J4048_15520	COG1979	alcohol dehydrogenase
J4048_15525	COG1979	alcohol dehydrogenase
J4048_15530	COG2155	Conserved Protein
J4048_15535	COG1098	S1 RNA binding domain
J4048_15540	COG0436	Aminotransferase
J4048_15545	COG1522	sequence-specific DNA binding
J4048_15550	COG2267	carboxylic ester hydrolase activity
J4048_15560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J4048_15565	COG2205	protein histidine kinase activity
J4048_15575	COG5018	Exonuclease
J4048_15580	COG2814	Major facilitator Superfamily
J4048_15585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4048_15590	COG3011	Protein conserved in bacteria
J4048_15600	COG3290	protein histidine kinase activity
J4048_15605	COG4565	transcriptional regulatory protein
J4048_15610	COG1744	ABC transporter substrate-binding protein PnrA-like
J4048_15615	COG3845	ABC transporter
J4048_15620	COG4603	Belongs to the binding-protein-dependent transport system permease family
J4048_15625	COG1079	Belongs to the binding-protein-dependent transport system permease family
J4048_15635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J4048_15635	COG2111	Na H antiporter
J4048_15640	COG2111	Na H antiporter
J4048_15645	COG1006	Multisubunit Na H antiporter MnhC subunit
J4048_15650	COG0651	ATP synthesis coupled electron transport
J4048_15655	COG1863	multisubunit Na H antiporter MnhE subunit
J4048_15660	COG2212	antiporter activity
J4048_15665	COG1320	monovalent cation:proton antiporter activity
J4048_15670	COG2050	protein possibly involved in aromatic compounds catabolism
J4048_15675	COG2197	response regulator
J4048_15680	COG4585	Histidine kinase
J4048_15690	COG0142	geranyltranstransferase activity
J4048_15705	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
J4048_15710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J4048_15715	COG1335	isochorismatase
J4048_15720	COG5506	Protein of unknown function (DUF1694)
J4048_15735	COG0628	permease
J4048_15745	COG1418	mRNA catabolic process
J4048_15750	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_15760	COG1511	domain protein
J4048_15765	COG1674	ftsk spoiiie
J4048_15765	COG0433	COG0433 Predicted ATPase
J4048_15770	COG4499	WXG100 protein secretion system (Wss), protein YukC
J4048_15775	COG5417	Belongs to the EsaB family
J4048_15780	COG4842	Belongs to the WXG100 family
J4048_15785	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
J4048_15785	COG2508	Transcriptional regulator
J4048_15790	COG0686	Belongs to the AlaDH PNT family
J4048_15795	COG5634	Uncharacterized conserved protein (DUF2278)
J4048_15800	COG3251	PFAM MbtH domain protein
J4048_15805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4048_15810	COG1535	isochorismatase
J4048_15810	COG3433	isochorismatase activity
J4048_15815	COG1021	2,3-dihydroxybenzoate-AMP ligase
J4048_15820	COG1169	isochorismate synthase
J4048_15825	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_15830	COG2819	hydrolase of the alpha beta superfamily
J4048_15835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J4048_15840	COG1268	BioY protein
J4048_15845	COG2056	Na+-H+ antiporter family
J4048_15855	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
J4048_15860	COG3584	3D domain protein
J4048_15875	COG1252	NADH dehydrogenase
J4048_15905	COG1131	(ABC) transporter
J4048_15925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4048_15930	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
J4048_15945	COG0316	Belongs to the HesB IscA family
J4048_15955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4048_15965	COG1252	NADH dehydrogenase
J4048_15970	COG4837	Protein of unknown function (DUF1462)
J4048_15975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J4048_15980	COG1506	peptidase
J4048_15980	COG4946	Tricorn protease homolog
J4048_15980	COG0823	Involved in the tonB-independent uptake of proteins
J4048_15990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4048_15995	COG0460	homoserine dehydrogenase
J4048_16000	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J4048_16005	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J4048_16010	COG0647	UMP catabolic process
J4048_16015	COG2445	Protein of unknown function DUF86
J4048_16020	COG4470	Protein conserved in bacteria
J4048_16030	COG0739	heme binding
J4048_16040	COG0737	Belongs to the 5'-nucleotidase family
J4048_16045	COG0730	response to heat
J4048_16050	COG1801	Protein of unknown function DUF72
J4048_16065	COG2508	Transcriptional regulator
J4048_16080	COG2814	Major facilitator Superfamily
J4048_16085	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J4048_16090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4048_16095	COG2356	endonuclease I
J4048_16100	COG3842	ATPase activity
J4048_16105	COG2188	Transcriptional regulator
J4048_16110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4048_16115	COG0395	ABC-type sugar transport system, permease component
J4048_16120	COG1175	transmembrane transport
J4048_16125	COG1653	transport
J4048_16130	COG2222	sugar isomerase
J4048_16135	COG0789	Transcriptional regulator
J4048_16160	COG0322	excinuclease ABC activity
J4048_16165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4048_16170	COG2226	methyltransferase
J4048_16180	COG3409	Peptidoglycan-binding domain 1 protein
J4048_16190	COG0719	Fe-S assembly protein
J4048_16195	COG0822	iron-sulfur transferase activity
J4048_16200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4048_16205	COG0719	Fe-S assembly protein
J4048_16210	COG0396	ATPase activity
J4048_16220	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J4048_16225	COG1464	Belongs to the NlpA lipoprotein family
J4048_16230	COG2011	ABC-type metal ion transport system permease component
J4048_16235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4048_16245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4048_16250	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
J4048_16265	COG1393	Belongs to the ArsC family
J4048_16270	COG1960	acyl-CoA dehydrogenase activity
J4048_16275	COG0183	Belongs to the thiolase family
J4048_16280	COG1024	Enoyl-CoA hydratase
J4048_16280	COG1250	3-hydroxyacyl-CoA dehydrogenase
J4048_16295	COG0477	Major facilitator Superfamily
J4048_16305	COG5577	PFAM Coat F domain
J4048_16310	COG1846	Transcriptional regulator
J4048_16315	COG0477	Major facilitator Superfamily
J4048_16320	COG0583	DNA-binding transcription factor activity
J4048_16340	COG1120	ATPase activity
J4048_16355	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_16360	COG0783	Belongs to the Dps family
J4048_16365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4048_16370	COG0745	RESPONSE REGULATOR receiver
J4048_16375	COG2205	protein histidine kinase activity
J4048_16375	COG2770	Histidine kinase
J4048_16385	COG1309	transcriptional regulator
J4048_16390	COG0114	fumarate hydratase activity
J4048_16400	COG0697	spore germination
J4048_16405	COG0814	amino acid
J4048_16415	COG2197	response regulator
J4048_16420	COG4585	Histidine kinase
J4048_16425	COG4758	membrane
J4048_16430	COG3595	metallopeptidase activity
J4048_16435	COG1842	Phage shock protein A
J4048_16440	COG4758	membrane
J4048_16445	COG2814	Major facilitator Superfamily
J4048_16450	COG2096	Adenosyltransferase
J4048_16455	COG1120	ATPase activity
J4048_16460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_16465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4048_16470	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_16475	COG3386	PFAM SMP-30 Gluconolaconase
J4048_16480	COG2205	protein histidine kinase activity
J4048_16485	COG0745	RESPONSE REGULATOR receiver
J4048_16495	COG1191	sigma factor activity
J4048_16505	COG2140	Oxalate decarboxylase
J4048_16515	COG1120	ATPase activity
J4048_16520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_16525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_16530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4048_16535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
J4048_16540	COG0531	amino acid
J4048_16550	COG1988	membrane-bound metal-dependent
J4048_16555	COG1368	sulfuric ester hydrolase activity
J4048_16560	COG1910	domain protein
J4048_16565	COG0725	ABC transporter, periplasmic molybdate-binding protein
J4048_16570	COG4149	molybdate abc transporter
J4048_16575	COG2197	response regulator
J4048_16580	COG3850	Histidine kinase
J4048_16585	COG1131	(ABC) transporter
J4048_16595	COG0842	Transport permease protein
J4048_16600	COG0656	L-ascorbic acid biosynthetic process
J4048_16620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J4048_16625	COG3973	AAA domain
J4048_16630	COG2860	membrane
J4048_16640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J4048_16645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J4048_16650	COG2217	Heavy metal translocating P-type atpase
J4048_16655	COG2217	Heavy metal translocating P-type atpase
J4048_16660	COG2608	mercury ion transmembrane transporter activity
J4048_16665	COG1937	Protein conserved in bacteria
J4048_16670	COG0673	inositol 2-dehydrogenase activity
J4048_16685	COG2814	Major facilitator Superfamily
J4048_16700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_16705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J4048_16710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_16715	COG1126	abc transporter atp-binding protein
J4048_16720	COG0765	amino acid transport
J4048_16725	COG0765	amino acid transport
J4048_16730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_16735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4048_16745	COG0583	DNA-binding transcription factor activity
J4048_16750	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_16755	COG2732	(Barnase) inhibitor
J4048_16760	COG2732	(Barnase) inhibitor
J4048_16775	COG0557	exoribonuclease II activity
J4048_16780	COG1647	Serine aminopeptidase, S33
J4048_16785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4048_16790	COG1476	TRANSCRIPTIONal
J4048_16795	COG1396	sequence-specific DNA binding
J4048_16800	COG1396	sequence-specific DNA binding
J4048_16805	COG1733	regulation of RNA biosynthetic process
J4048_16830	COG1131	(ABC) transporter
J4048_16835	COG1174	glycine betaine transport
J4048_16840	COG1732	Glycine betaine
J4048_16845	COG1174	glycine betaine transport
J4048_16850	COG1125	glycine betaine transport
J4048_16850	COG0517	IMP dehydrogenase activity
J4048_16855	COG1510	regulation of RNA biosynthetic process
J4048_16860	COG1174	glycine betaine transport
J4048_16865	COG1732	Glycine betaine
J4048_16870	COG1174	glycine betaine transport
J4048_16875	COG0517	IMP dehydrogenase activity
J4048_16875	COG1125	glycine betaine transport
J4048_16880	COG1510	regulation of RNA biosynthetic process
J4048_16885	COG2095	MarC family integral membrane protein
J4048_16890	COG3064	Membrane
J4048_16895	COG4640	response to antibiotic
J4048_16900	COG0456	acetyltransferase
J4048_16915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J4048_16935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4048_16940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J4048_16950	COG2234	aminopeptidase activity
J4048_16970	COG0126	phosphoglycerate kinase activity
J4048_16975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4048_16980	COG2390	Transcriptional regulator
J4048_16985	COG2814	Major facilitator Superfamily
J4048_16990	COG1609	Transcriptional regulator
J4048_17000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_17005	COG0583	DNA-binding transcription factor activity
J4048_17010	COG0697	spore germination
J4048_17015	COG1113	amino acid transport
J4048_17025	COG1609	Transcriptional regulator
J4048_17035	COG0561	phosphatase activity
J4048_17040	COG1737	Transcriptional regulator
J4048_17045	COG1070	Carbohydrate kinase
J4048_17070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_17075	COG2186	Transcriptional regulator
J4048_17080	COG1620	l-lactate permease
J4048_17085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
J4048_17095	COG5039	Polysaccharide pyruvyl transferase
J4048_17100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J4048_17105	COG0110	maltose O-acetyltransferase activity
J4048_17110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4048_17115	COG2244	polysaccharide biosynthetic process
J4048_17120	COG1216	Glycosyl transferase, family 2
J4048_17125	COG5039	Polysaccharide pyruvyl transferase
J4048_17130	COG1216	Glycosyl transferase, family 2
J4048_17140	COG0438	transferase activity, transferring glycosyl groups
J4048_17145	COG1215	transferase activity, transferring glycosyl groups
J4048_17150	COG0438	transferase activity, transferring glycosyl groups
J4048_17155	COG1086	Polysaccharide biosynthesis protein
J4048_17160	COG0489	protein tyrosine kinase activity
J4048_17165	COG3944	biosynthesis protein
J4048_17170	COG1396	sequence-specific DNA binding
J4048_17175	COG2272	Belongs to the type-B carboxylesterase lipase family
J4048_17180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J4048_17185	COG2364	Membrane
J4048_17190	COG0456	acetyltransferase
J4048_17195	COG3479	Phenolic acid decarboxylase
J4048_17255	COG2211	Major facilitator Superfamily
J4048_17260	COG1609	Transcriptional regulator
J4048_17270	COG0583	DNA-binding transcription factor activity
J4048_17275	COG2828	Protein conserved in bacteria
J4048_17280	COG2814	Major facilitator Superfamily
J4048_17280	COG0477	Major facilitator Superfamily
J4048_17285	COG1611	Belongs to the LOG family
J4048_17290	COG1694	Mazg nucleotide pyrophosphohydrolase
J4048_17295	COG0659	secondary active sulfate transmembrane transporter activity
J4048_17300	COG0288	reversible hydration of carbon dioxide
J4048_17305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4048_17310	COG4290	ribonuclease
J4048_17315	COG2162	N-hydroxyarylamine O-acetyltransferase activity
J4048_17320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_17330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J4048_17340	COG1051	belongs to the nudix hydrolase family
J4048_17345	COG0492	ferredoxin-NADP+ reductase activity
J4048_17350	COG0791	NLP P60 protein
J4048_17350	COG3883	PFAM NLP P60 protein
J4048_17355	COG0457	Tetratricopeptide repeat
J4048_17360	COG5002	protein histidine kinase activity
J4048_17365	COG0745	RESPONSE REGULATOR receiver
J4048_17375	COG1132	(ABC) transporter
J4048_17380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J4048_17380	COG0140	phosphoribosyl-ATP diphosphatase activity
J4048_17405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J4048_17420	COG4990	cell redox homeostasis
J4048_17425	COG0110	maltose O-acetyltransferase activity
J4048_17445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J4048_17455	COG2188	Transcriptional regulator
J4048_17460	COG1309	transcriptional regulator
J4048_17465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J4048_17470	COG1950	PFAM Membrane protein of
J4048_17475	COG1983	PspC domain protein
J4048_17480	COG3595	metallopeptidase activity
J4048_17495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4048_17505	COG4897	Protein conserved in bacteria
J4048_17510	COG0574	Belongs to the PEP-utilizing enzyme family
J4048_17510	COG3848	Pyruvate phosphate dikinase
J4048_17515	COG1309	transcriptional regulator
J4048_17520	COG2814	Major facilitator Superfamily
J4048_17570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4048_17580	COG0793	Belongs to the peptidase S41A family
J4048_17580	COG3409	Peptidoglycan-binding domain 1 protein
J4048_17585	COG3420	alginic acid biosynthetic process
J4048_17590	COG2177	Part of the ABC transporter FtsEX involved in
J4048_17595	COG2884	Cell division ATP-binding protein ftsE
J4048_17600	COG2010	Cytochrome c
J4048_17605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_17620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4048_17635	COG1516	flagellar protein fliS
J4048_17640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
J4048_17645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4048_17665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J4048_17670	COG1256	bacterial-type flagellum assembly
J4048_17670	COG4786	Flagellar basal body rod
J4048_17675	COG3418	PFAM FlgN family protein
J4048_17680	COG2747	anti-sigma28 factor FlgM
J4048_17690	COG1040	competence protein
J4048_17700	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
J4048_17705	COG1307	EDD domain protein, DegV family
J4048_17710	COG2197	response regulator
J4048_17715	COG4585	Histidine kinase
J4048_17720	COG1739	Uncharacterized protein family UPF0029
J4048_17725	COG1316	TRANSCRIPTIONal
J4048_17730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4048_17735	COG0438	transferase activity, transferring glycosyl groups
J4048_17740	COG1215	transferase activity, transferring glycosyl groups
J4048_17745	COG3206	protein involved in exopolysaccharide biosynthesis
J4048_17750	COG3307	-O-antigen
J4048_17755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J4048_17760	COG0297	glycogen (starch) synthase activity
J4048_17760	COG0438	transferase activity, transferring glycosyl groups
J4048_17765	COG2244	polysaccharide biosynthetic process
J4048_17775	COG0860	N-Acetylmuramoyl-L-alanine amidase
J4048_17775	COG2247	cell wall binding repeat
J4048_17780	COG2385	sporulation resulting in formation of a cellular spore
J4048_17780	COG2247	cell wall binding repeat
J4048_17790	COG1316	TRANSCRIPTIONal
J4048_17795	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J4048_17800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4048_17805	COG1134	teichoic acid transport
J4048_17810	COG1682	transport, permease protein
J4048_17815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4048_17825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J4048_17830	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
J4048_17835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4048_17840	COG4193	domain, Protein
J4048_17845	COG1482	cell wall glycoprotein biosynthetic process
J4048_17850	COG0697	spore germination
J4048_17855	COG0814	amino acid
J4048_17865	COG1215	transferase activity, transferring glycosyl groups
J4048_17870	COG2814	Major facilitator Superfamily
J4048_17875	COG1316	TRANSCRIPTIONal
J4048_17880	COG0561	phosphatase activity
J4048_17885	COG2433	Pfam Transposase IS66
J4048_17890	COG0791	NLP P60 protein
J4048_17900	COG2843	Capsule synthesis protein
J4048_17910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J4048_17915	COG0697	spore germination
J4048_17920	COG0814	amino acid
J4048_17930	COG1609	Transcriptional regulator
J4048_17935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4048_17945	COG1129	ABC transporter
J4048_17950	COG1172	Belongs to the binding-protein-dependent transport system permease family
J4048_17955	COG1879	ABC-type sugar transport system periplasmic component
J4048_17960	COG3103	Sh3 type 3 domain protein
J4048_17965	COG2249	NAD(P)H dehydrogenase (quinone) activity
J4048_17970	COG3527	Alpha-acetolactate decarboxylase
J4048_17975	COG0028	Belongs to the TPP enzyme family
J4048_17980	COG0583	DNA-binding transcription factor activity
J4048_17985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J4048_18000	COG5337	Spore coat protein CotH
J4048_18010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J4048_18020	COG0405	Gamma-glutamyltransferase
J4048_18025	COG1522	sequence-specific DNA binding
J4048_18030	COG2059	Chromate
J4048_18035	COG2059	Chromate
J4048_18090	COG5444	nuclease activity
J4048_18105	COG3878	Protein conserved in bacteria
J4048_18110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J4048_18115	COG4464	protein tyrosine phosphatase activity
J4048_18120	COG0489	protein tyrosine kinase activity
J4048_18125	COG3944	biosynthesis protein
J4048_18135	COG4715	Zinc finger, swim domain protein
J4048_18140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4048_18145	COG0561	phosphatase activity
J4048_18150	COG1349	DNA-binding transcription factor activity
J4048_18155	COG0629	single-stranded DNA binding
J4048_18180	COG0457	Tetratricopeptide repeat
J4048_18185	COG4786	Flagellar basal body rod
J4048_18190	COG4786	Flagellar basal body rod
J4048_18195	COG1077	Cell shape determining protein MreB Mrl
J4048_18200	COG1609	Transcriptional regulator
J4048_18205	COG1846	Transcriptional regulator
J4048_18210	COG2814	Major facilitator Superfamily
J4048_18215	COG1953	Uracil, thiamine, allantoin
J4048_18220	COG0477	Major facilitator Superfamily
J4048_18225	COG1335	isochorismatase
J4048_18230	COG0004	ammonium transporteR
J4048_18235	COG0347	Belongs to the P(II) protein family
J4048_18240	COG0772	Belongs to the SEDS family
J4048_18245	COG0671	phosphoesterase, PA-phosphatase related
J4048_18255	COG0739	heme binding
J4048_18260	COG1247	-acetyltransferase
J4048_18275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4048_18285	COG0726	polysaccharide deacetylase
J4048_18290	COG1959	2 iron, 2 sulfur cluster binding
J4048_18305	COG0831	urea catabolic process
J4048_18315	COG1994	Peptidase M50
J4048_18320	COG0457	Tetratricopeptide repeat
J4048_18330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J4048_18340	COG2304	oxidoreductase activity
J4048_18345	COG2304	oxidoreductase activity
J4048_18350	COG2385	sporulation resulting in formation of a cellular spore
J4048_18355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4048_18365	COG4836	Membrane
J4048_18435	COG0698	ribose 5-phosphate isomerase
J4048_18440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J4048_18450	COG0009	L-threonylcarbamoyladenylate synthase
J4048_18455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J4048_18475	COG2890	protein-(glutamine-N5) methyltransferase activity
J4048_18480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4048_18485	COG0346	lactoylglutathione lyase activity
J4048_18490	COG0789	Transcriptional regulator
J4048_18495	COG0679	Auxin Efflux Carrier
J4048_18500	COG0281	malic enzyme
J4048_18515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J4048_18520	COG1494	fructose-1,6-bisphosphatase
J4048_18525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4048_18535	COG0191	fructose-bisphosphate aldolase activity
J4048_18540	COG2204	response regulator
J4048_18545	COG4821	SIS domain
J4048_18560	COG0247	lactate metabolic process
J4048_18560	COG2181	nitrate reductase activity
J4048_18565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4048_18580	COG1132	(ABC) transporter
J4048_18585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4048_18595	COG2181	nitrate reductase activity
J4048_18600	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
J4048_18605	COG1140	nitrate reductase beta subunit
J4048_18610	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
J4048_18615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4048_18625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4048_18630	COG2223	nitrite transmembrane transporter activity
J4048_18640	COG4506	Protein conserved in bacteria
J4048_18650	COG3391	amine dehydrogenase activity
J4048_18655	COG3391	amine dehydrogenase activity
J4048_18660	COG0457	Tetratricopeptide repeat
J4048_18700	COG0010	Belongs to the arginase family
J4048_18705	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J4048_18710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4048_18725	COG1994	Peptidase M50
J4048_18730	COG1942	4-Oxalocrotonate Tautomerase
J4048_18735	COG1846	Transcriptional regulator
J4048_18740	COG0531	amino acid
J4048_18745	COG3465	dGTPase activity
J4048_18750	COG1078	dGTPase activity
J4048_18765	COG1695	Transcriptional regulator
J4048_18775	COG1131	(ABC) transporter
J4048_18780	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
J4048_18810	COG0583	DNA-binding transcription factor activity
J4048_18815	COG2855	membrane
J4048_18820	COG0280	phosphate acetyltransferase
J4048_18830	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_18835	COG0436	Aminotransferase
J4048_18865	COG2814	Major facilitator Superfamily
J4048_18870	COG2814	Major facilitator Superfamily
J4048_18875	COG0833	amino acid
J4048_18880	COG4187	Peptidase family M20/M25/M40
J4048_18885	COG1012	belongs to the aldehyde dehydrogenase family
J4048_18890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4048_18900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
J4048_18905	COG1091	dTDP-4-dehydrorhamnose reductase activity
J4048_18910	COG1088	dTDP-glucose 4,6-dehydratase activity
J4048_18915	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J4048_18920	COG3980	spore coat polysaccharide biosynthesis protein
J4048_18925	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
J4048_18930	COG2089	acid synthase
J4048_18935	COG0456	acetyltransferase
J4048_18940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J4048_18945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
J4048_18950	COG0463	Glycosyl transferase, family 2
J4048_18960	COG2363	Small membrane protein
J4048_18965	COG2233	PERMEase
J4048_18980	COG1216	Glycosyl transferase, family 2
J4048_18995	COG1695	Transcriptional regulator
J4048_19000	COG0351	phosphomethylpyrimidine kinase
J4048_19010	COG1621	beta-fructofuranosidase activity
J4048_19015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_19015	COG1263	PTS System
J4048_19020	COG3711	transcriptional antiterminator
J4048_19030	COG1404	Belongs to the peptidase S8 family
J4048_19035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J4048_19040	COG0778	Nitroreductase
J4048_19045	COG0772	Belongs to the SEDS family
J4048_19050	COG0454	-acetyltransferase
J4048_19070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J4048_19075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J4048_19080	COG2261	transglycosylase associated protein
J4048_19085	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
J4048_19090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J4048_19095	COG2246	polysaccharide biosynthetic process
J4048_19100	COG1309	transcriptional regulator
J4048_19120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J4048_19125	COG2837	iron assimilation
J4048_19130	COG2822	iron ion transport
J4048_19145	COG0583	DNA-binding transcription factor activity
J4048_19155	COG1346	cytolysis
J4048_19160	COG4895	conserved protein (DUF2196)
J4048_19165	COG0789	Transcriptional regulator
J4048_19170	COG5504	Zn-dependent protease
J4048_19175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4048_19180	COG0346	lactoylglutathione lyase activity
J4048_19185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_19190	COG1404	Belongs to the peptidase S8 family
J4048_19195	COG1442	glycosyl transferase family 8
J4048_19200	COG2357	RelA SpoT domain protein
J4048_19205	COG1575	Belongs to the MenA family. Type 1 subfamily
J4048_19220	COG1696	Membrane protein involved in D-alanine export
J4048_19230	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
J4048_19235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4048_19240	COG1486	melibiose metabolic process
J4048_19245	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4048_19250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_19255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_19260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4048_19260	COG3711	transcriptional antiterminator
J4048_19270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_19275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4048_19285	COG0640	Transcriptional regulator
J4048_19290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
J4048_19295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_19300	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4048_19305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4048_19310	COG2723	6-phospho-beta-galactosidase activity
J4048_19315	COG1940	carbohydrate kinase activity
J4048_19320	COG1482	cell wall glycoprotein biosynthetic process
J4048_19330	COG0753	catalase activity
J4048_19335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
J4048_19340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J4048_19345	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4048_19350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J4048_19355	COG4988	ABC transporter
J4048_19360	COG1294	oxidase, subunit
J4048_19365	COG1271	oxidase subunit
J4048_19370	COG3493	citrate carrier protein
J4048_19375	COG0726	polysaccharide deacetylase
J4048_19380	COG3842	ATPase activity
J4048_19385	COG2508	Transcriptional regulator
J4048_19390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_19400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4048_19415	COG4894	glucomannan catabolic process
J4048_19420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
J4048_19425	COG0500	methyltransferase
J4048_19430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4048_19445	COG0693	protein deglycase activity
J4048_19445	COG0753	catalase activity
J4048_19450	COG2851	Citrate transporter
J4048_19455	COG2273	Hydrolase Family 16
J4048_19460	COG3711	transcriptional antiterminator
J4048_19465	COG2270	Major facilitator Superfamily
J4048_19470	COG0513	Belongs to the DEAD box helicase family
J4048_19520	COG3209	COG3209 Rhs family protein
J4048_19530	COG0697	spore germination
J4048_19535	COG0589	response to stress
J4048_19540	COG2723	6-phospho-beta-galactosidase activity
J4048_19545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4048_19545	COG2190	(PTS) system
J4048_19545	COG1263	PTS System
J4048_19555	COG3507	Belongs to the glycosyl hydrolase 43 family
J4048_19580	COG0010	Belongs to the arginase family
J4048_19585	COG0833	amino acid
J4048_19590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
J4048_19595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J4048_19605	COG2390	Transcriptional regulator
J4048_19610	COG0561	phosphatase activity
J4048_19640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J4048_19645	COG5294	Protein conserved in bacteria
J4048_19650	COG0577	efflux transmembrane transporter activity
J4048_19655	COG1136	(ABC) transporter
J4048_19660	COG2205	protein histidine kinase activity
J4048_19665	COG0745	RESPONSE REGULATOR receiver
J4048_19670	COG2205	protein histidine kinase activity
J4048_19675	COG0745	RESPONSE REGULATOR receiver
J4048_19705	COG1082	Xylose isomerase domain protein TIM barrel
J4048_19715	COG2814	Major facilitator Superfamily
J4048_19745	COG1349	DNA-binding transcription factor activity
J4048_19750	COG0667	Aldo Keto reductase
J4048_19755	COG2814	Major facilitator Superfamily
J4048_19765	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_19770	COG2197	response regulator
J4048_19775	COG4585	Histidine kinase
J4048_19780	COG3239	Fatty acid desaturase
J4048_19785	COG1309	transcriptional regulator
J4048_19790	COG1012	belongs to the aldehyde dehydrogenase family
J4048_19795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J4048_19805	COG0640	Transcriptional regulator
J4048_19810	COG2814	Major facilitator Superfamily
J4048_19815	COG1714	RDD family
J4048_19825	COG0450	alkyl hydroperoxide reductase
J4048_19830	COG3634	alkyl hydroperoxide reductase activity
J4048_19835	COG3177	Filamentation induced by cAMP protein fic
J4048_19840	COG1113	amino acid transport
J4048_19850	COG2080	2 iron, 2 sulfur cluster binding
J4048_19865	COG2068	MobA-Related Protein
J4048_19870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J4048_19920	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
J4048_19925	COG0667	Aldo Keto reductase
J4048_19930	COG0456	acetyltransferase
J4048_19935	COG0457	Tetratricopeptide repeat
J4048_19940	COG0010	Belongs to the arginase family
J4048_19945	COG0833	amino acid
J4048_19950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4048_19955	COG5658	integral membrane protein
J4048_19960	COG0640	Transcriptional regulator
J4048_19965	COG3829	transcription factor binding
J4048_19975	COG0488	(ABC) transporter
J4048_19990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4048_20000	COG0745	RESPONSE REGULATOR receiver
J4048_20005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4048_20010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J4048_20015	COG4853	Protein conserved in bacteria
J4048_20020	COG4863	YycH protein
J4048_20025	COG5002	protein histidine kinase activity
J4048_20030	COG0745	RESPONSE REGULATOR receiver
J4048_20060	COG0346	lactoylglutathione lyase activity
J4048_20065	COG0305	Participates in initiation and elongation during chromosome replication
J4048_20080	COG3093	addiction module antidote protein HigA
J4048_20085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J4048_20090	COG0297	glycogen (starch) synthase activity
J4048_20100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
J4048_20105	COG0438	transferase activity, transferring glycosyl groups
J4048_20125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
J4048_20130	COG4241	membrane
J4048_20140	COG5577	PFAM Coat F domain
J4048_20145	COG1733	regulation of RNA biosynthetic process
J4048_20155	COG0697	spore germination
J4048_20160	COG1621	beta-fructofuranosidase activity
J4048_20165	COG1621	beta-fructofuranosidase activity
J4048_20170	COG1802	Transcriptional regulator
J4048_20175	COG2318	DinB family
J4048_20180	COG2211	Major facilitator Superfamily
J4048_20185	COG0583	DNA-binding transcription factor activity
J4048_20200	COG0778	Nitroreductase
J4048_20205	COG1846	Transcriptional regulator
J4048_20210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4048_20215	COG1846	Transcriptional regulator
J4048_20220	COG2153	protein acetylation
J4048_20230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J4048_20235	COG0583	DNA-binding transcription factor activity
J4048_20240	COG1028	Short-chain dehydrogenase reductase Sdr
J4048_20245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4048_20250	COG0697	spore germination
J4048_20255	COG1331	Highly conserved protein containing a thioredoxin domain
J4048_20260	COG1266	CAAX protease self-immunity
J4048_20265	COG2814	Major facilitator Superfamily
J4048_20265	COG0477	Major facilitator Superfamily
J4048_20270	COG0346	lactoylglutathione lyase activity
J4048_20275	COG1609	Transcriptional regulator
J4048_20280	COG0708	Exodeoxyribonuclease III
J4048_20285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4048_20290	COG2169	Transcriptional regulator
J4048_20300	COG0629	single-stranded DNA binding
J4048_20310	COG0012	GTP binding
J4048_20315	COG0243	molybdopterin cofactor binding
J4048_20320	COG4481	Protein conserved in bacteria
J4048_20325	COG3949	Membrane
J4048_20340	COG1475	DNA binding
J4048_20345	COG1192	Involved in chromosome partitioning
J4048_20370	COG1847	R3H domain protein
J4048_20375	COG0706	membrane insertase activity
J4048_20420	COG1191	sigma factor activity
J4048_20485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4048_20485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4048_20535	COG1525	nuclease
J4048_20580	COG0305	Participates in initiation and elongation during chromosome replication
J4048_20600	COG0513	Belongs to the DEAD box helicase family
J4048_20700	COG0457	Tetratricopeptide repeat
J4048_20770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4048_20795	COG3481	metal-dependent phosphohydrolase, HD sub domain
J4048_20870	COG1674	ftsk spoiiie
J4048_20930	COG3883	PFAM NLP P60 protein
J4048_20930	COG0791	NLP P60 protein
J4048_20940	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4048_20965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4048_21055	COG4112	unkown
J4048_21065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4048_21080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4048_21150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4048_21160	COG4474	Belongs to the UPF0398 family
J4048_21205	COG1705	Flagellar rod assembly protein muramidase FlgJ
J4048_21365	COG0187	DNA topoisomerase II activity
J4048_21455	COG0210	DNA helicase
J4048_21795	COG0629	single-stranded DNA binding
J4048_21805	COG0582	viral genome integration into host DNA
J4048_21835	COG1793	dna ligase
J4048_21855	COG1525	nuclease
J4048_21945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4048_21985	COG0457	Tetratricopeptide repeat
J4048_21990	COG1396	sequence-specific DNA binding
J4048_22125	COG0791	NLP P60 protein
J4048_22125	COG3883	PFAM NLP P60 protein