locus-tag class description MUS_0002 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) MUS_0003 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MUS_0004 ENOG410848D S4 domain protein YaaA MUS_0005 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MUS_0007 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MUS_0008 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MUS_0011 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MUS_0013 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) MUS_0014 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) MUS_0015 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) MUS_0016 ENOG4105BZW Glycerate kinase MUS_0018 ENOG4105ZMH deoxynucleoside kinase MUS_0020 ENOG4105VRS hydrolase family 18 MUS_0021 ENOG4105GTG Isochorismatase MUS_0022 ENOG4108Z6B deaminase MUS_0024 ENOG4105C6E dna polymerase iii MUS_0025 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) MUS_0026 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) MUS_0028 ENOG41067KS pro-sigma K processing MUS_0032 ENOG4105CDW Resistance protein MUS_0033 ENOG4105CXN decarboxylase MUS_0034 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) MUS_0035 ENOG4105X0R protein from nitrogen regulatory protein P-II MUS_0036 ENOG4105XVJ Protein of unknown function (DUF327) MUS_0037 ENOG4105FA2 dna polymerase iii MUS_0038 ENOG4105MA4 psp1 domain protein MUS_0040 ENOG41060K3 Methyltransferase MUS_0041 ENOG4105VC4 domain protein MUS_0042 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) MUS_0043 ENOG4105KRN Transcriptional regulator, abrb family MUS_0044 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MUS_0045 ENOG4105F8V Hydrolase, tatD family MUS_0046 ENOG41069ER domain protein MUS_0048 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MUS_0049 ENOG4105XFA sporulation peptidase YabG MUS_0050 ENOG4105W42 Veg protein MUS_0051 ENOG4105XEW small acid-soluble spore protein MUS_0052 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) MUS_0053 ENOG4105DFT pur operon repressor MUS_0054 ENOG4105KME endoribonuclease L-psp MUS_0055 ENOG4105K4W Could be involved in septation (By similarity) MUS_0056 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) MUS_0057 ENOG4105C5T Phosphoribosyl pyrophosphate synthase MUS_0058 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) MUS_0061 ENOG4108JA2 transcriptioN-repair coupling factor MUS_0062 ENOG4108M14 stage v sporulation protein t MUS_0064 ENOG4108IY2 MazG family MUS_0065 ENOG41082I2 s4 domain protein MUS_0066 ENOG4105VYY sporulation protein yabp MUS_0069 ENOG41060GV RNA binding s1 domain protein MUS_0074 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) MUS_0075 ENOG4108UGV hypoxanthine phosphoribosyltransferase MUS_0076 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) MUS_0078 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) MUS_0079 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) MUS_0080 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase MUS_0081 ENOG4105C6T cysteine synthase MUS_0082 ENOG4105CRQ synthase (Component I) MUS_0083 ENOG4105DDQ anthranilate synthase MUS_0084 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 MUS_0085 ENOG4105EEI dihydropteroate synthase MUS_0086 ENOG4105KRF dihydroneopterin aldolase MUS_0087 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MUS_0089 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) MUS_0090 ENOG4105CRK lysyL-tRNA synthetase MUS_0094 ENOG4108Z0C Uvrb UvrC protein MUS_0095 ENOG41066A3 ATP guanido phosphotransferase MUS_0097 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MUS_0098 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) MUS_0099 ENOG4105CTP PilT protein domain protein MUS_0100 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) MUS_0101 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) MUS_0102 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) MUS_0104 ENOG4105D7W serine acetyltransferase MUS_0106 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) MUS_0107 ENOG4105C2N RNA methyltransferase TrmH family group 3 MUS_0108 ENOG4105M0M Tetracycline resistance protein MUS_0112 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) MUS_0113 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) MUS_0115 ENOG4108VZM 50s ribosomal protein L10 MUS_0116 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MUS_0117 ENOG4107Y49 methyltransferase MUS_0118 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MUS_0119 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MUS_0120 ENOG4105XPM ribosomal protein MUS_0121 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) MUS_0122 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) MUS_0123 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) MUS_0124 ENOG4107SKW Inherit from COG: Alpha beta hydrolase MUS_0126 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) MUS_0128 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) MUS_0129 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) MUS_0130 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity MUS_0131 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) MUS_0132 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) MUS_0133 ENOG41082SA 50s ribosomal protein l29 MUS_0134 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal MUS_0136 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits MUS_0137 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) MUS_0138 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) MUS_0139 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) MUS_0140 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) MUS_0141 ENOG4105VPB 50S ribosomal protein L30 MUS_0143 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) MUS_0144 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MUS_0146 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MUS_0147 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits MUS_0148 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MUS_0149 ENOG4108JJB ABC transporter MUS_0150 ENOG4108JJB ABC transporter MUS_0151 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) MUS_0152 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) MUS_0153 ENOG4108I0C methyltransferase MUS_0157 ENOG4105D1F ATP-binding protein MUS_0160 ENOG4108NMV polysaccharide deacetylase MUS_0167 ENOG4108JPW Aminotransferase MUS_0170 ENOG4105CHH sulfate transporter MUS_0172 ENOG4108SA1 esterase MUS_0176 ENOG410874W AraC family transcriptional regulator MUS_0177 ENOG4105EHZ conserved protein UCP016719 MUS_0178 ENOG4105D17 glycoside hydrolase, family 3 domain protein MUS_0181 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate MUS_0183 ENOG4105EWC Purine nucleoside phosphorylase MUS_0184 ENOG4105EMN RNA polymerase sigma factor MUS_0186 ENOG4105C8B TIGR00159 family MUS_0187 ENOG4107U5W ybbr family MUS_0188 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) MUS_0197 ENOG4106K80 MUS_0199 ENOG41067MG lrgb family MUS_0201 ENOG41061AU MarR family Transcriptional regulator MUS_0204 ENOG4105BZU Histidine kinase MUS_0205 ENOG4105WH1 Two component transcriptional regulator luxr family MUS_0206 ENOG4105CJ1 ABC, transporter MUS_0211 ENOG4106DDH Sporulation-specific SASP protein MUS_0214 ENOG4107QTZ amino acid MUS_0215 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) MUS_0218 ENOG4107VXM glycerophosphoryl diester phosphodiesterase MUS_0219 ENOG4105CXY transporter MUS_0226 ENOG4107SCQ Iron-containing alcohol dehydrogenase MUS_0227 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR MUS_0229 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase MUS_0230 ENOG4107ZTW SNARE associated Golgi MUS_0233 ENOG4105C72 UPF0176 protein MUS_0235 ENOG4105CM2 brancheD-chain amino acid aminotransferase MUS_0236 ENOG4108IQI permease MUS_0237 ENOG4108J5H Homocysteine s-methyltransferase MUS_0240 ENOG4105CSV Glutaminase MUS_0248 ENOG4105DGI Alkaline phosphatase MUS_0249 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) MUS_0250 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) MUS_0251 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) MUS_0252 ENOG4107EPV Aminotransferase class V MUS_0253 ENOG4105C0R drug resistance transporter emrb qaca subfamily MUS_0254 ENOG4105J7D transcriptional regulator MUS_0256 ENOG4107RB3 L-asparaginase MUS_0257 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold MUS_0258 ENOG41060AI SEC-C motif MUS_0259 ENOG4107SET aldo keto reductase MUS_0266 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MUS_0268 ENOG4105DSE periplasmic solute binding protein MUS_0269 ENOG4105DIK (ABC) transporter MUS_0271 ENOG4105DEN Luciferase family MUS_0272 ENOG4108N0M stress protein MUS_0273 ENOG4106FN3 tellurium resistance protein MUS_0274 ENOG4106FN3 tellurium resistance protein MUS_0275 ENOG4107TS3 membrane protein, TerC MUS_0276 ENOG4108TTB tellurium resistance protein MUS_0278 ENOG41079KZ Major Facilitator Superfamily MUS_0279 ENOG4108IJ7 Glycine betaine MUS_0280 ENOG4107SQ8 Glycine betaine MUS_0287 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MUS_0293 ENOG4105EIG urea carboxylase-associated protein 1 MUS_0294 ENOG4107RA1 nh(3)-dependent nad( ) synthetase MUS_0296 ENOG4105I1F Resistance protein MUS_0298 ENOG4105DJB Major Facilitator Superfamily MUS_0299 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) MUS_0300 ENOG4105I82 acetyl xylan esterase MUS_0301 ENOG410756H nucleotidyltransferase MUS_0304 ENOG4105C26 Dehydrogenase MUS_0305 ENOG4105CK7 Sodium proline symporter MUS_0307 ENOG4107YHD transcriptional regulator MUS_0308 ENOG4105CAY ferredoxin--nadp reductase MUS_0309 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MUS_0310 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit MUS_0311 ENOG4108IFG nitrite reductase, (NAD(P)H) MUS_0312 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) MUS_0316 ENOG4105CKI cobalamin synthesis protein MUS_0317 ENOG4105E2A Dehydrogenase MUS_0318 ENOG4105HHM rdd domain containing protein MUS_0320 ENOG4105CS2 ec 3.2.1.21 MUS_0324 ENOG41080HJ 6-phospho 3-hexuloisomerase MUS_0325 ENOG4108VA3 3-hexulose-6-phosphate synthase MUS_0326 ENOG4105KVH Transcriptional regulator MUS_0329 ENOG4105CEY Amp-dependent synthetase and ligase MUS_0333 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) MUS_0336 ENOG4105CDA abc transporter atp-binding protein MUS_0337 ENOG4105DRP amino acid AbC transporter MUS_0339 ENOG4106P55 Transcriptional regulator MUS_0340 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase MUS_0341 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) MUS_0342 ENOG41069ZX MUS_0343 ENOG41069ZX MUS_0344 ENOG4105DUX Transporter MUS_0347 ENOG4105E1K spore germination protein MUS_0351 ENOG4105CPU Monooxygenase MUS_0352 ENOG4108XSB acetyltransferase, (GNAT) family MUS_0353 ENOG4105EAB amino acid AbC transporter MUS_0354 ENOG4108HW4 amino acid AbC transporter MUS_0356 ENOG4105CH2 amidohydrolase MUS_0357 ENOG4108PGP mmge prpd family protein MUS_0359 ENOG4107WD8 ABC transporter, permease MUS_0361 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MUS_0362 ENOG4105BZU Histidine kinase MUS_0366 ENOG4105CFH Aspartokinase MUS_0368 ENOG4105DHS permease protein MUS_0369 ENOG4105CM4 permease protein MUS_0370 ENOG4108IPW abc transporter atp-binding protein MUS_0373 ENOG4105R8C Transcriptional regulator MUS_0374 ENOG4108DBC nitroreductase MUS_0375 ENOG41067V3 Antibiotic biosynthesis monooxygenase MUS_0376 ENOG4105YVS arsR family transcriptional regulator MUS_0378 ENOG4108JPW Aminotransferase MUS_0379 ENOG4105C26 Dehydrogenase MUS_0382 ENOG4105H9W Short-chain dehydrogenase reductase Sdr MUS_0383 ENOG4105KTB nuclear export factor GLE1 MUS_0384 ENOG4108T5E Copper resistance protein MUS_0385 ENOG4108ZYE Transcriptional regulator MUS_0389 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase MUS_0396 ENOG4105E7W lamb ycsf family protein MUS_0397 ENOG4105C5A transporter MUS_0399 ENOG4105CFM UPF0317 protein MUS_0400 ENOG4105P4J Allophanate hydrolase, subunit 1 MUS_0402 ENOG4107258 Transcriptional regulator MUS_0403 ENOG4105XJB lipolytic protein G-D-S-L family MUS_0405 ENOG41061CK Antibiotic biosynthesis monooxygenase MUS_0406 ENOG4107RVG penicillin-binding protein MUS_0407 ENOG4107QM2 Aldo Keto reductase MUS_0408 ENOG4105ETD TRANSCRIPTIONal MUS_0411 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MUS_0414 ENOG410606W general stress protein MUS_0416 ENOG4105VCH membrane MUS_0418 ENOG4105C9U ATP-dependent DNA helicase RecQ MUS_0421 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) MUS_0422 ENOG4107R8N Glycosyl transferase, family 2 MUS_0424 ENOG4105C0X amino acid MUS_0433 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) MUS_0436 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) MUS_0437 ENOG4105RXJ MUS_0438 ENOG4105KPY Small multidrug resistance protein MUS_0439 ENOG4105EU9 MUS_0443 ENOG41082W1 Cupin 2, conserved barrel domain protein MUS_0446 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit MUS_0447 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MUS_0448 ENOG4108MRH transcriptional regulatory protein MUS_0449 ENOG4107QJT sodium dicarboxylate symporter MUS_0450 ENOG4106F5Q Membrane MUS_0451 ENOG4105CJ1 ABC, transporter MUS_0454 ENOG4105FDT acyl-CoA dehydrogenase MUS_0458 ENOG4105SZ6 Thioredoxin MUS_0459 ENOG4105CPF Cell wall formation (By similarity) MUS_0460 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) MUS_0462 ENOG4105C1J atp-dependent rna helicase MUS_0463 ENOG410905X membrane-flanked domain protein MUS_0464 ENOG4105CKV Membrane MUS_0466 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) MUS_0467 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein MUS_0468 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MUS_0470 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) MUS_0471 ENOG4107MMM Anti-sigma-factor antagonist MUS_0472 ENOG4105FUA antagonist MUS_0473 ENOG4107SGM protein serine threonine phosphatase MUS_0474 ENOG4105WN5 stage II sporulation protein MUS_0475 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) MUS_0477 ENOG41064BQ Phosphatase MUS_0480 ENOG410906U SprT-like MUS_0482 ENOG4105CSH Transporter MUS_0485 ENOG4108ZMQ domain protein MUS_0489 ENOG4108Z40 Transcriptional regulator MUS_0490 ENOG4108RYK Nad-dependent epimerase dehydratase MUS_0492 ENOG4108IND Tetr family transcriptional regulator MUS_0493 ENOG4105ECK Fatty Acid Desaturase MUS_0495 ENOG4105VEQ Cold shock protein MUS_0496 ENOG4108VJ1 Transcriptional regulator (CarD family MUS_0497 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase MUS_0498 ENOG4105C72 UPF0176 protein MUS_0499 ENOG4105VFE sira family MUS_0500 ENOG4107TPS domain protein MUS_0501 ENOG4105VFE sira family MUS_0502 ENOG41087NI Sulfite exporter TauE/SafE MUS_0506 ENOG4105IRW patatin-like phospholipase family protein MUS_0508 ENOG4107RCH Diaminopropionate ammonia-lyase MUS_0510 ENOG4105KME endoribonuclease L-psp MUS_0511 ENOG4105C44 Serine transporter MUS_0512 ENOG4105CH2 amidohydrolase MUS_0513 ENOG4108MCI Transcriptional regulator, ARAC family MUS_0514 ENOG4105CE7 Amidase, hydantoinase carbamoylase family MUS_0515 ENOG4107U9B transcriptional regulator MUS_0516 ENOG4105DXI Major Facilitator superfamily MUS_0519 ENOG4105DNP FAD linked oxidase domain protein MUS_0521 ENOG4105PGM cation diffusion facilitator family transporter MUS_0522 ENOG4105H3G oxidoreductase MUS_0527 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MUS_0533 ENOG4105DWF phosphomethylpyrimidine kinase MUS_0537 ENOG4105DQ4 alcohol dehydrogenase MUS_0538 ENOG4105VUF Transcriptional regulator MUS_0542 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MUS_0546 ENOG4105EQ0 Major Facilitator superfamily MUS_0547 ENOG4108JGH Tetr family transcriptional regulator MUS_0549 ENOG4105T38 integral membrane protein MUS_0551 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MUS_0554 ENOG4105E2A Dehydrogenase MUS_0555 ENOG4105PGS Spore coat protein MUS_0557 ENOG4106UW1 Major Facilitator superfamily MUS_0561 ENOG4105ENE Histidine kinase MUS_0562 ENOG4108VB1 regulatoR MUS_0563 ENOG4105EYF MMPL domain protein MUS_0567 ENOG4108JYZ YitT family MUS_0569 ENOG4105C2C drug resistance transporter, Bcr CflA MUS_0570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MUS_0574 ENOG41090E6 transcriptional regulator MERR family MUS_0577 ENOG4105F2W methyltransferase MUS_0579 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) MUS_0580 ENOG4105DRR Transcriptional regulator, GntR family MUS_0585 ENOG4105FQP Beta-lactamase MUS_0588 ENOG41090UD (LipO)protein MUS_0589 ENOG4108SUT Major Facilitator Superfamily MUS_0590 ENOG4108TZY GntR Family Transcriptional Regulator MUS_0591 ENOG4105JXH GntR family transcriptional regulator MUS_0592 ENOG4105DJ2 Major Facilitator Superfamily MUS_0596 ENOG4107QTZ amino acid MUS_0600 ENOG4107QNK )-transporter MUS_0603 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) MUS_0604 ENOG4105K8N protein family UPF0079, ATPase MUS_0605 ENOG41072GX Peptidase M22 Glycoprotease MUS_0606 ENOG410801F ribosomal-protein-alanine acetyltransferase MUS_0607 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MUS_0608 ENOG4105C5H ABC transporter MUS_0609 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MUS_0610 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) MUS_0611 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) MUS_0612 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) MUS_0614 ENOG4108TYN CAAX amino terminal protease family protein MUS_0615 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) MUS_0616 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MUS_0618 ENOG4105PGZ NB-ARC domain MUS_0619 ENOG4105CPQ Dehydrogenase MUS_0620 ENOG4105CT4 transporter MUS_0623 ENOG41087YS Phage shock protein A MUS_0624 ENOG4105DQX Zinc finger domain MUS_0625 ENOG4108WV1 Pfam:DUF477 MUS_0627 ENOG4105EXC Acyl-transferase MUS_0629 ENOG4108P49 AntiSigma factor MUS_0630 ENOG4105JVQ RNA Polymerase MUS_0636 ENOG4107STQ Multicopper oxidase MUS_0637 ENOG4105C85 amino acid MUS_0640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MUS_0644 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MUS_0645 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain MUS_0649 ENOG4105E5W Transporter MUS_0653 ENOG4105C7N Xanthine uracil vitamin C permease MUS_0658 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) MUS_0659 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit MUS_0660 ENOG4105C83 adenylosuccinate lyase MUS_0661 ENOG4105C8V SAICAR synthetase MUS_0662 ENOG4105VR9 phosphoribosylformylglycinamidine synthase MUS_0663 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I MUS_0664 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii MUS_0666 ENOG4105CXB phosphoribosylaminoimidazole synthetase MUS_0667 ENOG4108V3E phosphoribosylglycinamide formyltransferase MUS_0668 ENOG4105DC1 bifunctional purine biosynthesis protein purh MUS_0669 ENOG4105C12 Phosphoribosylglycinamide synthetase MUS_0672 ENOG4108R5T secreted protein MUS_0673 ENOG4105KGF protein, YerC YecD MUS_0674 ENOG4105CBC glutamate synthase MUS_0678 ENOG4105C4R Atp-dependent dna helicase MUS_0679 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) MUS_0681 ENOG4105CRN Aminoglycoside phosphotransferase MUS_0682 ENOG4105KT7 mgtC SapB transporter MUS_0683 ENOG4105CK7 Sodium proline symporter MUS_0684 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MUS_0685 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MUS_0686 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) MUS_0687 ENOG4108IG5 Transcriptional regulator MUS_0689 ENOG4105CBD Diacylglycerol kinase MUS_0690 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MUS_0691 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) MUS_0693 ENOG4105CJ1 ABC, transporter MUS_0706 ENOG4106BHF MUS_0707 ENOG4105CDY transcriptional regulatory protein MUS_0709 ENOG41075D4 Aminoglycoside 6-adenylyltransferase MUS_0712 ENOG4105WEF catalase MUS_0713 ENOG4105M18 -acetyltransferase MUS_0715 ENOG4105H67 Protein of unknown function (DUF421) MUS_0716 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) MUS_0717 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MUS_0722 ENOG4106I4J membrane MUS_0723 ENOG41082F9 transcriptional regulator MUS_0724 ENOG41061H0 Monooxygenase MUS_0725 ENOG4108R1P MUS_0726 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MUS_0731 ENOG4105CJ1 ABC, transporter MUS_0734 ENOG4105E0M Sulfatase MUS_0736 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase MUS_0738 ENOG41090R9 glycosyltransferase MUS_0739 ENOG4107R51 Glycosyl transferase, family 2 MUS_0740 ENOG41090R9 glycosyltransferase MUS_0741 ENOG4105EU0 Major facilitator Superfamily MUS_0742 ENOG4105CUB amino acid MUS_0743 ENOG4105C26 Dehydrogenase MUS_0744 ENOG4105FKZ Methyl-accepting chemotaxis MUS_0745 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MUS_0746 ENOG4107TVC Glycosyl transferase, family 2 MUS_0747 ENOG4105C5H ABC transporter MUS_0748 ENOG4107SWG transcriptional regulator MERR family MUS_0749 ENOG4105DXB Major Facilitator superfamily MUS_0750 ENOG4105C5H ABC transporter MUS_0751 ENOG4105FDU atp-dependent rna helicase MUS_0755 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein MUS_0758 ENOG4108J20 pectate lyase MUS_0759 ENOG4107QPK )-transporter MUS_0764 ENOG4108VAC response regulator MUS_0770 ENOG4108Z6X (sortase) family MUS_0775 ENOG4108MRH transcriptional regulatory protein MUS_0780 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) MUS_0781 ENOG4108RPX mosc domain containing protein MUS_0785 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) MUS_0793 ENOG4105C5Y PTS System MUS_0794 ENOG4105CG3 alpha amylase, catalytic region MUS_0795 ENOG4107414 GntR family transcriptional regulator MUS_0796 ENOG4108RCM Nitroreductase MUS_0799 ENOG4105CGH 5'-nucleotidase MUS_0800 ENOG4107RKG DJ-1/PfpI family MUS_0801 ENOG4105ETE Transcriptional regulator (LacI family MUS_0802 ENOG4105E2X shikimate dehydrogenase MUS_0803 ENOG4105FF2 Type I DHQase MUS_0806 ENOG4105KJF protein tyrosine phosphatase MUS_0808 ENOG4107U9T Pfam:Ribonuclease_BN MUS_0811 ENOG4108ISG Major Facilitator MUS_0812 ENOG4105UPD Calcium Proton MUS_0814 ENOG4105D8X mechanosensitive ion channel MUS_0822 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_0824 ENOG4106KE4 Dehydrogenase MUS_0826 ENOG4105D7N magnesium and cobalt transport protein CorA MUS_0828 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MUS_0835 ENOG4107RUY (E1 component), alpha subunit MUS_0837 ENOG4107QKR Dehydrogenase MUS_0839 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family MUS_0841 ENOG4105F8D glycoside hydrolase family 4 MUS_0842 ENOG4108Q3X Transcriptional regulator MUS_0843 ENOG4105CI1 PTS System MUS_0844 ENOG4105BZ1 (ABC) transporter MUS_0845 ENOG4105BZ1 (ABC) transporter MUS_0847 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase MUS_0849 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MUS_0851 ENOG4105U3E Transcriptional regulator MUS_0853 ENOG4105DYS nad(p)h dehydrogenase (quinone) MUS_0854 ENOG4105H93 Acyltransferase family MUS_0857 ENOG4108YYS metal-dependent hydrolase (By similarity) MUS_0864 ENOG410834F Transcriptional regulator MUS_0866 ENOG4105JAB phenazine biosynthesis protein, phzf family MUS_0867 ENOG4107Y03 Nitroreductase MUS_0870 ENOG4105ECP epimerase MUS_0871 ENOG410902V Modulates RecA activity (By similarity) MUS_0873 ENOG4105F27 Major Facilitator MUS_0875 ENOG4108TCS Glutamyl endopeptidase MUS_0879 ENOG4106AKJ MUS_0880 ENOG4105D74 hydrolase MUS_0882 ENOG4105CKK Glycosyl transferase, family 2 MUS_0883 ENOG4105EJV Membrane MUS_0884 ENOG41067AE Membrane-bound metal-dependent hydrolase MUS_0885 ENOG4105CEN a g-specific adenine glycosylase MUS_0886 ENOG4106BXE MUS_0887 ENOG4105CAN Short-chain dehydrogenase reductase Sdr MUS_0891 ENOG4105BZ1 (ABC) transporter MUS_0892 ENOG4107NBY Membrane MUS_0893 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MUS_0894 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MUS_0895 ENOG4105G5W regulator Fur family MUS_0896 ENOG4105TUA UPF0295 protein MUS_0901 ENOG4107S6Z Na H antiporter MUS_0902 ENOG4105EC3 peptidase S51, dipeptidase E MUS_0903 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) MUS_0904 ENOG4105DNP FAD linked oxidase domain protein MUS_0906 ENOG4105DEF Extracellular solute-binding protein, family 5 MUS_0909 ENOG4105C3U ABC transporter MUS_0910 ENOG4108JQ7 (ABC) transporter MUS_0914 ENOG4105E2Y ABC, transporter MUS_0915 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein MUS_0916 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component MUS_0920 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) MUS_0921 ENOG4107D63 MUS_0922 ENOG4105VZ8 Transcriptional regulator MUS_0924 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) MUS_0926 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) MUS_0931 ENOG4105CYN Serine protein kinase MUS_0935 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes MUS_0936 ENOG4105CW7 secretion protein, HlyD family MUS_0937 ENOG4105C0R drug resistance transporter emrb qaca subfamily MUS_0938 ENOG4105CS1 NAD(P)H quinone oxidoreductase MUS_0941 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family MUS_0942 ENOG4105CZV ABC transporter MUS_0943 ENOG4105CJ1 ABC, transporter MUS_0944 ENOG4108TU7 Inherit from COG: (ABC) transporter MUS_0945 ENOG4105VEQ Cold shock protein MUS_0947 ENOG4105BZU Histidine kinase MUS_0958 ENOG4108YBP pseudouridine synthase MUS_0960 ENOG41080XP Cbs domain MUS_0961 ENOG4107YBY Hydrolase MUS_0962 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MUS_0963 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MUS_0965 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator MUS_0967 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) MUS_0968 ENOG4105C6V Glycerol-3-phosphate dehydrogenase MUS_0970 ENOG4105BZU Histidine kinase MUS_0971 ENOG4105WH1 Two component transcriptional regulator luxr family MUS_0979 ENOG4105ED1 spovr family MUS_0980 ENOG4105G6Z alkaline phosphatase MUS_0983 ENOG4105BZN citrate synthase MUS_0984 ENOG4105CYX Short-chain dehydrogenase reductase Sdr MUS_0985 ENOG4105CUB amino acid MUS_0986 ENOG4105C8J )-transporter MUS_0988 ENOG4105J37 MUS_0989 ENOG4108AEY RNA polymerase sigma factor MUS_0990 ENOG4105F6E Acyl-transferase MUS_0991 ENOG4105C37 (CBS) domain MUS_0994 ENOG4105CHM Aminotransferase MUS_0995 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase MUS_0997 ENOG4105C37 (CBS) domain MUS_0999 ENOG4105WMR Protein CrcB homolog MUS_1000 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MUS_1003 ENOG4105D64 Mechanosensitive ion channel MUS_1004 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MUS_1005 ENOG4107VMI polysaccharide deacetylase MUS_1006 ENOG4105F0I Aminotransferase MUS_1007 ENOG4105W1N transcriptional regulator MUS_1008 ENOG4105IIP Membrane MUS_1011 ENOG4105BZ1 (ABC) transporter MUS_1014 ENOG4105BZ1 (ABC) transporter MUS_1018 ENOG410839P MUS_1020 ENOG4106MP8 UPF0754 membrane protein MUS_1021 ENOG4105WZB UPF0342 protein MUS_1022 ENOG4105F1N DNA alkylation repair MUS_1024 ENOG4105D4P Coproporphyrinogen iii oxidase MUS_1026 ENOG4107S91 Sodium hydrogen exchanger MUS_1027 ENOG4105NCW Trka-c domain protein MUS_1029 ENOG4105CGU Enoyl-CoA hydratase MUS_1031 ENOG4108IUX (ABC) transporter MUS_1032 ENOG4105RHA ABC transporter, permease MUS_1034 ENOG4107VRP DNA repair exonuclease MUS_1036 ENOG4106D4I domain protein MUS_1039 ENOG4105EQI Metal Dependent Phosphohydrolase MUS_1041 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MUS_1050 ENOG4105NBU tryptophan transport protein MUS_1051 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) MUS_1052 ENOG4105K59 histidine triad (HIT) protein MUS_1062 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation MUS_1063 ENOG4105BZ4 penicillin-binding protein MUS_1064 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) MUS_1065 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MUS_1066 ENOG4105C1Q protoporphyrinogen oxidase MUS_1068 ENOG4105ECB domain protein MUS_1072 ENOG4105DER m42 family MUS_1075 ENOG4108RQ5 Beta-lactamase domain-containing protein MUS_1076 ENOG4105DF9 Lipoate-protein, ligase MUS_1078 ENOG4105CEY Amp-dependent synthetase and ligase MUS_1080 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 MUS_1083 ENOG4108HUF Transporter MUS_1085 ENOG4107TB6 phosphoglycerate mutase MUS_1087 ENOG4107F3J Amp-dependent synthetase and ligase MUS_1088 ENOG4107ZYJ bioY protein MUS_1089 ENOG4106YBV Methyl-accepting chemotaxis MUS_1093 ENOG4105XVF Competence transcription factor MUS_1094 ENOG4108ZMX Domain of unknown function (DU1801) MUS_1097 ENOG4105X3H Excalibur domain protein MUS_1098 ENOG4105K8R UPF0145 protein MUS_1100 ENOG4106CAD Protein of unknown function (DUF3311) MUS_1101 ENOG41060YP MUS_1104 ENOG4107SCK Monooxygenase MUS_1105 ENOG4108INS Transcriptional regulator MUS_1106 ENOG4108KK1 membrane protein AbrB duplication MUS_1108 ENOG4108IG5 Transcriptional regulator MUS_1110 ENOG4108QY0 Membrane MUS_1111 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination MUS_1112 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation MUS_1114 ENOG4105EYH Exonuclease MUS_1123 ENOG4105ERH Fumarylacetoacetate hydrolase MUS_1127 ENOG4105CAQ asparagine synthetase MUS_1129 ENOG4105UQX Mate efflux family protein MUS_1130 ENOG4106HBX Transcriptional Regulator AraC Family MUS_1131 ENOG4105ETE Transcriptional regulator (LacI family MUS_1133 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) MUS_1134 ENOG4105SF0 DinB family MUS_1135 ENOG4108ZUB Lysine exporter protein (Lyse ygga) MUS_1136 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MUS_1137 ENOG4105MYW Pentapeptide repeat protein MUS_1138 ENOG4105MA6 gCN5-related N-acetyltransferase MUS_1141 ENOG4108VPT UPF0234 protein MUS_1142 ENOG4105QNR S1 RNA binding domain protein MUS_1144 ENOG4105DIH basic membrane MUS_1145 ENOG4105C8Q Methyl-accepting chemotaxis MUS_1146 ENOG4107E6A Cytochrome p-450 MUS_1148 ENOG4105EPR degv family MUS_1149 ENOG4107AYK membrAne MUS_1151 ENOG41073B9 MUS_1153 ENOG4108KP7 hydrolase MUS_1154 ENOG4108MXZ Esterase MUS_1155 ENOG4105VG1 fes assembly suf system protein MUS_1156 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) MUS_1157 ENOG4105IQ5 FAD linked oxidase domain protein MUS_1159 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MUS_1161 ENOG4105CAS nag kinase MUS_1162 ENOG4105C8Y Acetylornithine aminotransferase MUS_1163 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain MUS_1166 ENOG4105DBV ornithine carbamoyltransferase MUS_1172 ENOG4107RMD Basic membrane lipoprotein MUS_1175 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MUS_1176 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MUS_1178 ENOG4105C3U ABC transporter MUS_1179 ENOG4108JQ7 (ABC) transporter MUS_1182 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MUS_1186 ENOG4108J59 Extracellular solute-binding protein, family 5 MUS_1187 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MUS_1188 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MUS_1190 ENOG4108JQ7 (ABC) transporter MUS_1193 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) MUS_1194 ENOG4108ZCF integral membrane protein MUS_1195 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis MUS_1197 ENOG4105DPN Oligoendopeptidase f MUS_1200 ENOG4105T58 Dithiol-disulfide isomerase MUS_1201 ENOG4108Z18 K06886 hemoglobin MUS_1202 ENOG4105E4C Lytic transglycosylase catalytic MUS_1203 ENOG4105MIX Adenylate cyclase MUS_1206 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) MUS_1207 ENOG4105EMS pseudouridine synthase MUS_1208 ENOG4107S1Q Phosphatase MUS_1210 ENOG4105ETU transcriptional activator (TenA MUS_1211 ENOG4108VEU Thiamine monophosphate synthase MUS_1215 ENOG4105D06 uba thif-type nad fad binding protein MUS_1216 ENOG4105DWF phosphomethylpyrimidine kinase MUS_1217 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH MUS_1218 ENOG4107A88 MUS_1228 ENOG4105ENA helicase MUS_1232 ENOG4105CJ1 ABC, transporter MUS_1235 ENOG4108ZMI UPF0477 protein MUS_1237 ENOG4105C28 cystathionine MUS_1238 ENOG4105C28 cystathionine MUS_1239 ENOG4105VTR Integrase MUS_1261 ENOG4105E4C Lytic transglycosylase catalytic MUS_1279 ENOG4106BHF MUS_1284 ENOG410907G MUS_1286 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase MUS_1289 ENOG4105C0R drug resistance transporter emrb qaca subfamily MUS_1292 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase MUS_1293 ENOG4105CMR udp-glucose 4-epimerase MUS_1294 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) MUS_1295 ENOG4105CK1 PTS System MUS_1296 ENOG4105VCP PTS System MUS_1303 ENOG4105KT7 mgtC SapB transporter MUS_1307 ENOG4108IEG Formate dehydrogenase Alpha subunit MUS_1309 ENOG4106A3M Cytochrome p-450 MUS_1310 ENOG41087PP glycosyltransferase MGT family MUS_1312 ENOG4105EXQ uroporphyrinogen iii synthase hem4 MUS_1313 ENOG4105C4B ABC transporter, permease MUS_1314 ENOG4108IXI (ABC) transporter MUS_1316 ENOG4105Q95 Cupin 2, conserved barrel domain protein MUS_1320 ENOG4105D2H Uronic isomerase MUS_1321 ENOG4105CT4 transporter MUS_1322 ENOG4107KJX Transcriptional regulator MUS_1323 ENOG4107QZW Altronate oxidoreductase MUS_1324 ENOG4105CTX dehydratase MUS_1325 ENOG4107TSN permease MUS_1329 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase MUS_1331 ENOG4105KWG Pfam:DUF1696 MUS_1332 ENOG4105K7W phage-related replication protein MUS_1334 ENOG410635T phage-like element pbsx protein MUS_1344 ENOG4105X7F MUS_1345 ENOG41068G1 MUS_1351 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MUS_1355 ENOG4105CJ3 phosphate transporter MUS_1356 ENOG4107GRR phosphate transport regulator MUS_1358 ENOG4107R7I amino acid MUS_1361 ENOG4105EDW glycosyl transferase, family 39 MUS_1362 ENOG4105CKK Glycosyl transferase, family 2 MUS_1364 ENOG4105C0H protease MUS_1367 ENOG4108ME1 Peptidase M55 D-aminopeptidase MUS_1368 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MUS_1369 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MUS_1370 ENOG4105C3U ABC transporter MUS_1372 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MUS_1373 ENOG4105DTQ mandelate racemase muconate lactonizing MUS_1375 ENOG4105DTQ mandelate racemase muconate lactonizing MUS_1377 ENOG4108JQ7 (ABC) transporter MUS_1378 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) MUS_1379 ENOG4107TUM Amidinotransferase MUS_1380 ENOG4108S4H thioesterase Superfamily protein MUS_1381 ENOG4108428 Inherit from COG: -acetyltransferase MUS_1383 ENOG41080TC multidrug resistance protein MUS_1384 ENOG4105CIY formyltetrahydrofolate deformylase MUS_1385 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) MUS_1388 ENOG4105K56 Transcriptional regulator MUS_1389 ENOG4108ZHJ Organic hydroperoxide resistance protein MUS_1394 ENOG4107TVC Glycosyl transferase, family 2 MUS_1398 ENOG4105D8G Major Facilitator superfamily MUS_1399 ENOG4108Y4K DNA-binding transcriptional activator MUS_1400 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) MUS_1401 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin MUS_1404 ENOG4108W7F transporter, permease MUS_1405 ENOG4108JJB ABC transporter MUS_1406 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein MUS_1408 ENOG4105VRS hydrolase family 18 MUS_1410 ENOG4105CJW magnesium transporter MUS_1411 ENOG4105V75 Transcriptional regulator MUS_1417 ENOG4105DQE DNA ligase MUS_1418 ENOG4105FDF Could be involved in DNA repair (By similarity) MUS_1420 ENOG4107T5V SNARE associated Golgi MUS_1422 ENOG4107TS3 membrane protein, TerC MUS_1423 ENOG4108WZW RNA polymerase sigma MUS_1425 ENOG410681C small acid-soluble spore protein MUS_1428 ENOG4105D0M Protease HtpX homolog MUS_1430 ENOG410900G Protein of unknown function (DUF421) MUS_1432 ENOG4108TGC Acyltransferase MUS_1433 ENOG4105BZU Histidine kinase MUS_1434 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MUS_1436 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) MUS_1438 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MUS_1440 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate MUS_1441 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) MUS_1442 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) MUS_1443 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) MUS_1446 ENOG4105BZU Histidine kinase MUS_1448 ENOG41090MY MarR family Transcriptional regulator MUS_1449 ENOG4105ER2 Ompa motb domain protein MUS_1450 ENOG4105E14 MotA TolQ exbB proton channel MUS_1454 ENOG4108K88 Membrane MUS_1457 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) MUS_1458 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase MUS_1459 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) MUS_1460 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr MUS_1464 ENOG4105F0V Cell wall hydrolase MUS_1467 ENOG4105C59 p-type ATPase MUS_1468 ENOG4105DC7 peptidase M24 MUS_1471 ENOG4105CID antiterminator MUS_1473 ENOG4105KRI phosphocarrier protein (HPr MUS_1474 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) MUS_1476 ENOG4105F6S Spore photoproduct lyase MUS_1477 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer MUS_1478 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MUS_1480 ENOG4105K4I Scp-like extracellular MUS_1482 ENOG4105BZU Histidine kinase MUS_1483 ENOG4105CHM Aminotransferase MUS_1485 ENOG4107R88 Chemotaxis protein (CheV) MUS_1486 ENOG4105UIN MUS_1488 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein MUS_1490 ENOG4105K6S Short-chain dehydrogenase reductase Sdr MUS_1492 ENOG4105EPM Diguanylate phosphodiesterase MUS_1494 ENOG4107IN1 Protein of unknown function (DUF1797) MUS_1495 ENOG4108XRC Protein of unknown function (DUF458) MUS_1502 ENOG4105NQC Flavodoxin MUS_1506 ENOG4105D8X mechanosensitive ion channel MUS_1507 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MUS_1510 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) MUS_1511 ENOG4105D06 uba thif-type nad fad binding protein MUS_1512 ENOG4105CVM Molybdenum cofactor synthesis domain protein MUS_1513 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein MUS_1514 ENOG4108ZAF Molybdopterin MUS_1515 ENOG41067WU Molybdopterin converting factor (Subunit 1) MUS_1518 ENOG4107X8C Efflux transporter RND family MFP subunit MUS_1519 ENOG4105C19 ABC transporter MUS_1520 ENOG4107RBB ABC transporter, permease MUS_1521 ENOG4105E98 transcriptional regulator DeoR family MUS_1522 ENOG4105DE4 1-phosphofructokinase MUS_1523 ENOG4105DM4 PTS System MUS_1527 ENOG4105C5H ABC transporter MUS_1528 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) MUS_1534 ENOG4105BZU Histidine kinase MUS_1536 ENOG4107ZYR domain protein MUS_1537 ENOG4105CPN adenine deaminase MUS_1538 ENOG4105CN5 Metallo-Beta-Lactamase MUS_1539 ENOG4106148 UPF0356 protein MUS_1540 ENOG4108X4Q Hydrolase MUS_1541 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MUS_1544 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MUS_1545 ENOG4105C0W non-ribosomal peptide synthetase MUS_1546 ENOG4107SQU synthase MUS_1547 ENOG4105C0W non-ribosomal peptide synthetase MUS_1548 ENOG4107SQU synthase MUS_1549 ENOG4107SQU synthase MUS_1550 ENOG4107SQU synthase MUS_1551 ENOG4105C0W non-ribosomal peptide synthetase MUS_1552 ENOG4105FQP Beta-lactamase MUS_1554 ENOG4105CPP Dehydrogenase, E1 component MUS_1555 ENOG4105C7S Dehydrogenase MUS_1556 ENOG4107QN2 dihydrolipoyl dehydrogenase MUS_1561 ENOG4105CXN decarboxylase MUS_1562 ENOG4105WBI UPF0223 protein MUS_1565 ENOG4105ECY inositol monophosphatase MUS_1567 ENOG4105D4Y metalloprotease MUS_1571 ENOG4105CI3 gtp-binding protein typa MUS_1572 ENOG4105QA2 MUS_1575 ENOG4108IAB Phoh family MUS_1577 ENOG4105CSV Glutaminase MUS_1596 ENOG4105E4C Lytic transglycosylase catalytic MUS_1617 ENOG4105ZUG MUS_1619 ENOG4107D0N MUS_1629 ENOG4105CSV Glutaminase MUS_1631 ENOG4105CNI cell division protein FtsW MUS_1632 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) MUS_1634 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) MUS_1637 ENOG4105BZ9 Cytochrome C oxidase, subunit I MUS_1638 ENOG4105CCU oxidase (Subunit III) MUS_1639 ENOG41064X9 cytochrome C oxidase subunit IV MUS_1642 ENOG41080XQ Signal transduction protein with cbs domains MUS_1643 ENOG4106UY4 Inherit from COG: Scp-like extracellular MUS_1649 ENOG4106H78 methyltransferase MUS_1650 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) MUS_1651 ENOG4105H20 Sporulation integral membrane protein YlbJ MUS_1652 ENOG4105D78 K07001 NTE family protein MUS_1653 ENOG41063PX domain protein MUS_1654 ENOG4105CDE UPF0348 protein MUS_1656 ENOG4105KNH Nucleic acid-binding protein MUS_1661 ENOG4108V6E Cell division protein mraZ MUS_1662 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) MUS_1664 ENOG4105CJN penicillin-binding protein MUS_1666 ENOG4105CJN penicillin-binding protein MUS_1667 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MUS_1668 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) MUS_1669 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) MUS_1670 ENOG4105CNI cell division protein FtsW MUS_1671 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) MUS_1672 ENOG4105D4A Cell wall formation (By similarity) MUS_1673 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) MUS_1674 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) MUS_1675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) MUS_1677 ENOG4105FFI sigma-e processing peptidase spoiiga MUS_1678 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_1680 ENOG4105DKW ABC transporter MUS_1683 ENOG4105WR5 sporulation protein, YlmC YmxH family MUS_1684 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase MUS_1685 ENOG4105DFA alanine racemase domain protein MUS_1686 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) MUS_1687 ENOG41067XK integral membrane protein MUS_1688 ENOG4105DBK s4 domain protein MUS_1690 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) MUS_1693 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) MUS_1694 ENOG4105C34 Pseudouridine synthase MUS_1695 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) MUS_1698 ENOG4105CXT aspartate transcarbamylase MUS_1700 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain MUS_1701 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain MUS_1702 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) MUS_1703 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) MUS_1704 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) MUS_1705 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) MUS_1709 ENOG4107RIQ Sulfate adenylate transferase MUS_1711 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MUS_1712 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein MUS_1713 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein MUS_1715 ENOG4105F23 Fibronectin-binding protein MUS_1717 ENOG4105DSJ YicC domain protein MUS_1718 ENOG4105KC4 UPF0296 protein MUS_1719 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) MUS_1721 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase MUS_1722 ENOG4105C25 Primosomal protein n' MUS_1723 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MUS_1724 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) MUS_1725 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B MUS_1726 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs MUS_1727 ENOG4108ZF3 Phosphatase MUS_1728 ENOG4105D9P serine threonine protein kinase MUS_1729 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) MUS_1730 ENOG4105DJV ribulose-phosphate 3-epimerase MUS_1731 ENOG4105FJ0 thiamine MUS_1733 ENOG4105VB9 50S ribosomal protein l28 MUS_1734 ENOG4108ZAA Alkaline-shock protein MUS_1735 ENOG4105DP4 dak2 domain fusion protein ylov MUS_1737 ENOG4105EJQ L-serine dehydratase MUS_1738 ENOG4105CB5 ATP-dependent DNA helicase recG MUS_1739 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) MUS_1740 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) MUS_1741 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MUS_1742 ENOG4105CHR reductase MUS_1743 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MUS_1744 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) MUS_1745 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) MUS_1746 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MUS_1748 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) MUS_1750 ENOG4105K5M 30s ribosomal protein S16 MUS_1751 ENOG4108BW8 UPF0109 protein MUS_1754 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) MUS_1756 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) MUS_1757 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MUS_1759 ENOG4105VM1 flagellar MUS_1760 ENOG4105CMV Succinyl-CoA synthetase subunit beta MUS_1761 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha MUS_1764 ENOG4105C79 DNA protecting protein DprA MUS_1766 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MUS_1767 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) MUS_1768 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MUS_1769 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) MUS_1770 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) MUS_1772 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) MUS_1773 ENOG4108ZC9 flagellar basal-body rod protein flgc MUS_1774 ENOG4105VQ0 flagellar hook-basal body complex protein fliE MUS_1775 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) MUS_1776 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MUS_1779 ENOG4106YF4 Flagellar biosynthesis chaperone MUS_1781 ENOG410696Y Flagellar hook-length control protein MUS_1782 ENOG410822I Flagellar hook capping protein MUS_1783 ENOG4108JQA flagellar MUS_1784 ENOG41068WV flagellar FlbD family protein MUS_1786 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MUS_1787 ENOG4105DD5 Flagellar motor switch protein MUS_1788 ENOG4107YTP response regulator receiver protein MUS_1790 ENOG4105CN7 Flagellar biosynthetic protein FliP MUS_1791 ENOG4105VS8 Flagellar biosynthetic protein fliq MUS_1792 ENOG4105D19 Role in flagellar biosynthesis (By similarity) MUS_1793 ENOG4105D00 flagellar biosynthetic protein flhB MUS_1794 ENOG4105D7B Flagellar biosynthesis protein flha MUS_1795 ENOG4105FZW flagellar biosynthesis regulator FlhF MUS_1797 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) MUS_1798 ENOG4105CBS Chea signal transduction histidine kinase MUS_1799 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis MUS_1801 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) MUS_1802 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_1804 ENOG4105CE9 30S ribosomal protein S2 MUS_1806 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) MUS_1807 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) MUS_1808 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MUS_1809 ENOG4105KNE Phosphatidate cytidylyltransferase MUS_1811 ENOG4105DZP Membrane-associated zinc metalloprotease MUS_1812 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) MUS_1813 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) MUS_1814 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) MUS_1815 ENOG4105CHV Transcription elongation factor NusA MUS_1816 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination MUS_1817 ENOG4105VHM ribosomal protein MUS_1818 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) MUS_1819 ENOG4105W7A Protein of unknown function (DUF503) MUS_1820 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) MUS_1821 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) MUS_1822 ENOG4105DTN riboflavin biosynthesis protein ribF MUS_1823 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) MUS_1825 ENOG4105C1V Peptidase, M16 MUS_1827 ENOG4105E35 Dipicolinate synthase subunit A MUS_1828 ENOG4108S0H Dipicolinic acid synthetase, b subunit MUS_1829 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MUS_1831 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MUS_1833 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit MUS_1836 ENOG4105FDP GntR family transcriptional regulator MUS_1839 ENOG4105EYF MMPL domain protein MUS_1843 ENOG4108RKS Short-chain dehydrogenase reductase Sdr MUS_1844 ENOG4105XZV Protein of unknown function (DUF3243) MUS_1847 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase MUS_1848 ENOG4105CEV competence damage-inducible protein MUS_1849 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) MUS_1851 ENOG4108A04 Beta-lactamase MUS_1853 ENOG4105D48 metallophosphoesterase MUS_1854 ENOG4105MCT stage V sporulation protein S MUS_1855 ENOG4105CPQ Dehydrogenase MUS_1856 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MUS_1857 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MUS_1861 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) MUS_1868 ENOG4108151 Beta-lactamase domain protein MUS_1869 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MUS_1870 ENOG4108JA1 polyketide synthase MUS_1871 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MUS_1872 ENOG41062T2 Acyl carrier protein MUS_1873 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase MUS_1874 ENOG4108MGH Enoyl-CoA hydratase MUS_1875 ENOG4108KQ6 Enoyl-CoA hydratase MUS_1877 ENOG4105C0W non-ribosomal peptide synthetase MUS_1879 ENOG4107SQU synthase MUS_1885 ENOG4105C0W non-ribosomal peptide synthetase MUS_1888 ENOG4106A3M Cytochrome p-450 MUS_1889 ENOG4105WFK nuclease MUS_1891 ENOG4105XPP Protein of unknown function (DUF1275) MUS_1893 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin MUS_1896 ENOG4105K7W phage-related replication protein MUS_1897 ENOG4108X3M OsmC Ohr family protein MUS_1902 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) MUS_1909 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MUS_1910 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MUS_1912 ENOG4105U6W MutT NUDIX family protein MUS_1913 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MUS_1915 ENOG4106F1P AAA ATPase, central domain protein MUS_1916 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MUS_1917 ENOG4105CXI aluminum resistance protein MUS_1918 ENOG4105KV4 Transcriptional regulator MUS_1919 ENOG4105VTR Integrase MUS_1922 ENOG4107Y9E nuclease MUS_1927 ENOG41090AA MUS_1930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MUS_1943 ENOG4105E4C Lytic transglycosylase catalytic MUS_1973 ENOG4105K70 DNA-binding protein MUS_1974 ENOG4105ZUG MUS_1979 ENOG4108NE4 MUS_1991 ENOG4106J6E MUS_1994 ENOG4107D0N MUS_2008 ENOG4108J9Q DNA ligase MUS_2009 ENOG4108RAV Conserved protein MUS_2013 ENOG4105K7W phage-related replication protein MUS_2015 ENOG4106YR8 MUS_2016 ENOG41088HM MUS_2019 ENOG4106PTB DnaB-like helicase C terminal domain MUS_2020 ENOG4106IVX MUS_2022 ENOG4106J9J DNA polymerase MUS_2042 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MUS_2044 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MUS_2045 ENOG4106ITI Glutaredoxin MUS_2046 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MUS_2050 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) MUS_2051 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) MUS_2064 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) MUS_2072 ENOG4105CT4 transporter MUS_2073 ENOG4105DSG hydrolase family 43 MUS_2075 ENOG4105C93 Xylose Isomerase MUS_2076 ENOG4105CMG Carbohydrate kinase MUS_2077 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) MUS_2079 ENOG4105D29 Helix-turn-helix type 11 domain protein MUS_2080 ENOG4105SF0 DinB family MUS_2081 ENOG4105DQ4 alcohol dehydrogenase MUS_2084 ENOG4105EPI acetyltransferase, (GNAT) family MUS_2090 ENOG4106BHF MUS_2091 ENOG4106ANW SMI1_KNR4 MUS_2101 ENOG4108M1A Chitin-binding protein MUS_2102 ENOG41068WN MUS_2108 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MUS_2109 ENOG4105K7W phage-related replication protein MUS_2114 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) MUS_2116 ENOG4108SVB resolvase MUS_2117 ENOG4105VPS UPF0291 protein MUS_2118 ENOG4105CV1 Transketolase (EC 2.2.1.1) MUS_2120 ENOG4105VXM UPF0154 protein MUS_2122 ENOG4107QIV Cytochrome c biogenesis protein MUS_2130 ENOG4108I0Z Aconitate hydratase MUS_2131 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MUS_2134 ENOG41067CD Small, acid-soluble spore protein Tlp MUS_2136 ENOG4105MI2 MUS_2137 ENOG4105W8X HesB YadR YfhF-family protein MUS_2138 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) MUS_2139 ENOG4105K4P CoA-binding domain protein MUS_2141 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MUS_2147 ENOG4105CPQ Dehydrogenase MUS_2148 ENOG4108UHU Aldolase MUS_2149 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) MUS_2150 ENOG4105DMW Dehydrogenase reductase MUS_2152 ENOG4108I5G Major Facilitator superfamily MUS_2155 ENOG4105FVX MUS_2164 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_2166 ENOG4107SYN Glycosyl hydrolases family 43 MUS_2172 ENOG4105DTD Dehydrogenase MUS_2173 ENOG4108IIH CoA-transferase subunit B MUS_2174 ENOG4105D6N CoA-transferase, subunit a MUS_2175 ENOG4105CY2 Citrate transporter MUS_2177 ENOG4106A3M Cytochrome p-450 MUS_2178 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) MUS_2179 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) MUS_2181 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MUS_2182 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MUS_2183 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) MUS_2185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MUS_2186 ENOG4107T5V SNARE associated Golgi MUS_2187 ENOG4107QX3 carboxylase MUS_2188 ENOG4105E39 Enoyl-CoA hydratase MUS_2189 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase MUS_2190 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit MUS_2191 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MUS_2192 ENOG4105CEY Amp-dependent synthetase and ligase MUS_2193 ENOG4105C1G acyl-Coa dehydrogenase MUS_2194 ENOG4105F32 YngK protein MUS_2195 ENOG4106U2H Protein of unknown function (DUF1360) MUS_2198 ENOG4105CEY Amp-dependent synthetase and ligase MUS_2202 ENOG4105C0W non-ribosomal peptide synthetase MUS_2210 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family MUS_2211 ENOG4108N2V aldose 1-epimerase MUS_2212 ENOG4107QJQ Mate efflux family protein MUS_2216 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) MUS_2217 ENOG4108RWP Major Facilitator Superfamily protein MUS_2218 ENOG4105WAB arsR family transcriptional regulator MUS_2219 ENOG4105C22 threonyL-tRNA synthetase MUS_2223 ENOG4105CB2 alcohol dehydrogenase MUS_2225 ENOG4105BZ8 glutamate synthase MUS_2226 ENOG4105CBC glutamate synthase MUS_2227 ENOG4105C5Q Transcriptional regulator MUS_2228 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) MUS_2233 ENOG4108UB7 MUS_2234 ENOG4105IE8 Alpha-ketoglutarate permease MUS_2235 ENOG4107U6E carbohydrate kinase FGGY MUS_2236 ENOG4108M3J Dehydrogenase MUS_2237 ENOG4108J2R molybdopterin oxidoreductase MUS_2243 ENOG4106ANW SMI1_KNR4 MUS_2244 ENOG4106BHF MUS_2251 ENOG4108Z7R Chaperone CsaA MUS_2252 ENOG4105FTV AraC Family Transcriptional Regulator MUS_2254 ENOG4108W8B Beta-lactamase domain protein MUS_2256 ENOG4105KTU Transcriptional regulator, arsr family MUS_2259 ENOG4108SJC Membrane MUS_2265 ENOG41069ER domain protein MUS_2267 ENOG4105C9U ATP-dependent DNA helicase RecQ MUS_2269 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) MUS_2270 ENOG4105SCY DNAK suppressor MUS_2280 ENOG4105C26 Dehydrogenase MUS_2281 ENOG4105EWU Squalene--hopene cyclase MUS_2282 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MUS_2283 ENOG4105C8J )-transporter MUS_2284 ENOG4105C09 Bile acid MUS_2286 ENOG4105C7S Dehydrogenase MUS_2287 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 MUS_2288 ENOG4107T89 von Willebrand factor, type A MUS_2289 ENOG4105GMT ATPase associated with various cellular activities aaa_5 MUS_2291 ENOG4105K4H Nlp p60 protein MUS_2293 ENOG41087PP glycosyltransferase MGT family MUS_2296 ENOG4107QMU Mate efflux family protein MUS_2297 ENOG4106SCS STAS domain MUS_2301 ENOG4105FR1 rard protein MUS_2304 ENOG41090U3 tautomerase MUS_2308 ENOG4105FBA Phospholipase Carboxylesterase MUS_2311 ENOG4105E1V na solute symporter MUS_2314 ENOG4105CS2 ec 3.2.1.21 MUS_2315 ENOG4108S3Y transcriptional regulator MUS_2319 ENOG4108VXD carboxy-peptidase MUS_2322 ENOG4106Z5R MUS_2323 ENOG410841Q phosphoesterase PA-phosphatase related protein MUS_2330 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein MUS_2331 ENOG4108TSC N-acetyltransferase MUS_2332 ENOG4107S4Y M20 DapE family protein YgeY MUS_2335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MUS_2337 ENOG4105FTQ Dna gyrase MUS_2345 ENOG4105C5E polysaccharide biosynthesis protein MUS_2346 ENOG4105E0X reductase MUS_2347 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MUS_2349 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) MUS_2350 ENOG41090WU lipolytic protein G-D-S-L family MUS_2351 ENOG4108KF3 Electron transport protein SCO1 SenC MUS_2353 ENOG4105C7B Threonine dehydratase MUS_2355 ENOG4108UT2 hemolysin iii MUS_2357 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) MUS_2358 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) MUS_2360 ENOG4107YX5 Pfam:DUF548 MUS_2361 ENOG4108Y6J UPF0403 protein MUS_2362 ENOG4105C01 Dihydroxy-acid dehydratase MUS_2365 ENOG4108V06 Glutathione peroxidase MUS_2367 ENOG4105CVG Homoserine O-transsuccinylase MUS_2375 ENOG41081VK Ribonuclease MUS_2380 ENOG410890F Dynamin family MUS_2383 ENOG41065KQ synthase MUS_2402 ENOG41068G1 MUS_2405 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj MUS_2408 ENOG4108FKH Transglycosylase SLT domain MUS_2441 ENOG4105QBX endodeoxyribonuclease RusA MUS_2450 ENOG4108ZUE Phage regulatory protein rha MUS_2453 ENOG41067QW Transcriptional regulator MUS_2455 ENOG4105VTR Integrase MUS_2456 ENOG4105C2W permease MUS_2457 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) MUS_2458 ENOG4105CTD carboxy-peptidase MUS_2459 ENOG4105DVT helicase MUS_2462 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) MUS_2463 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) MUS_2464 ENOG4108UKS UPF0398 protein MUS_2465 ENOG4107X2U Inherit from COG: Exonuclease-like protein MUS_2466 ENOG4108I5C dEAD DEAH box helicase MUS_2475 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) MUS_2476 ENOG4105BZ4 penicillin-binding protein MUS_2478 ENOG4105CSM endonuclease III MUS_2480 ENOG4105C5S asparaginyl-tRNA synthetase MUS_2481 ENOG4105CHM Aminotransferase MUS_2483 ENOG4105YAC MUS_2484 ENOG4105DVT helicase MUS_2485 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) MUS_2487 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) MUS_2489 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate MUS_2490 ENOG4105CPK Glycosyl transferase (Group 1 MUS_2491 ENOG4105FJR Lmbe family MUS_2492 ENOG4108Z5K methylglyoxal synthase MUS_2493 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) MUS_2494 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase MUS_2495 ENOG4108JYZ YitT family MUS_2496 ENOG4105F0F Oxalate decarboxylase MUS_2500 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) MUS_2504 ENOG41068YB TPR repeat-containing protein MUS_2506 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase MUS_2508 ENOG4105CIH Imidazole acetol-phosphate transaminase MUS_2511 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) MUS_2514 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase MUS_2515 ENOG4105DK0 Indole-3-glycerol phosphate synthase MUS_2517 ENOG4105CRQ synthase (Component I) MUS_2518 ENOG4105KHN chorismate mutase MUS_2520 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase MUS_2521 ENOG4105BZU Histidine kinase MUS_2522 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) MUS_2523 ENOG4105EAH synthase MUS_2524 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MUS_2525 ENOG4105XXQ heptaprenyl diphosphate synthase component I MUS_2526 ENOG4105WP2 Tryptophan RNA-binding attenuator protein MUS_2527 ENOG4105EUJ GTP cyclohydrolase i MUS_2528 ENOG4105K70 DNA-binding protein MUS_2530 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) MUS_2534 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase MUS_2535 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) MUS_2539 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) MUS_2540 ENOG4105CAT Cytidine monophosphate kinase MUS_2543 ENOG4105MSI germination protein ypeb MUS_2545 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) MUS_2546 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase MUS_2549 ENOG4107RGJ metallophosphoesterase MUS_2552 ENOG4105I7S Abortive infection protein MUS_2553 ENOG4105C9U ATP-dependent DNA helicase RecQ MUS_2554 ENOG4105T7X MUS_2556 ENOG4108SAX Membrane MUS_2558 ENOG4108JQ1 Dehydrogenase MUS_2561 ENOG4105BZU Histidine kinase MUS_2562 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MUS_2563 ENOG4105CRE cytochrome C MUS_2564 ENOG4107TWT Cytochrome c biogenesis protein MUS_2566 ENOG4105FE9 pseudouridine synthase MUS_2568 ENOG4108JIC nucleoside recognition domain protein MUS_2570 ENOG4105DZ1 carboxypeptidase MUS_2572 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) MUS_2573 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) MUS_2576 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) MUS_2577 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) MUS_2578 ENOG4108R6K riboflavin synthase, subunit alpha MUS_2583 ENOG4107ZE5 PPIases accelerate the folding of proteins MUS_2584 ENOG4105PTM secreted protein MUS_2585 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MUS_2587 ENOG4105G6R Stage v sporulation protein ae MUS_2589 ENOG4105CZ3 stage V sporulation protein ad MUS_2590 ENOG41090VF Stage v sporulation protein ac MUS_2593 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_2594 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) MUS_2595 ENOG41082AN stage II sporulation protein MUS_2596 ENOG4105DZ1 carboxypeptidase MUS_2597 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) MUS_2598 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) MUS_2599 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MUS_2601 ENOG4105I3K Ferric uptake regulator, Fur family MUS_2602 ENOG4105MZ9 stage II sporulation protein m MUS_2606 ENOG4105DFD Na H antiporter MUS_2607 ENOG4108IJ0 Aspartate ammonia-lyase MUS_2608 ENOG4105HDK L-asparaginase MUS_2609 ENOG4108IMY Transcriptional regulator MUS_2611 ENOG4108YZ4 nudix hydrolase MUS_2613 ENOG4105CPC Aldo Keto reductase MUS_2617 ENOG4106HZJ MUS_2618 ENOG4105RHY Pfam:UPF0157 MUS_2619 ENOG4105KAC Antibiotic biosynthesis monooxygenase MUS_2620 ENOG4108XET gCN5-related N-acetyltransferase MUS_2621 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MUS_2625 ENOG4105C02 permease MUS_2627 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase MUS_2628 ENOG4105CS9 pantothenic acid kinase MUS_2630 ENOG4108IXY short-chain dehydrogenase reductase MUS_2631 ENOG41069FQ Metallo-beta-lactamase superfamily MUS_2632 ENOG4105II7 pyrroline-5-carboxylate reductase MUS_2633 ENOG4108KQ6 Enoyl-CoA hydratase MUS_2634 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase MUS_2635 ENOG4106A3M Cytochrome p-450 MUS_2637 ENOG4105C0W non-ribosomal peptide synthetase MUS_2640 ENOG4105C0W non-ribosomal peptide synthetase MUS_2642 ENOG4105C0W non-ribosomal peptide synthetase MUS_2652 ENOG4105C0W non-ribosomal peptide synthetase MUS_2662 ENOG4105CHR reductase MUS_2664 ENOG4105CEY Amp-dependent synthetase and ligase MUS_2667 ENOG4107QKG PfaD family MUS_2669 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) MUS_2671 ENOG4108K70 Transcriptional regulator MUS_2674 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MUS_2676 ENOG410861F 50S ribosomal protein L33 MUS_2677 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MUS_2678 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase MUS_2679 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) MUS_2680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MUS_2682 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) MUS_2683 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) MUS_2685 ENOG4108ZVT methylmalonyl-coA epimerase MUS_2686 ENOG4108VZI ErfK ybiS ycfS ynhG family protein MUS_2687 ENOG4108QEG Membrane MUS_2688 ENOG4105CDA abc transporter atp-binding protein MUS_2689 ENOG4105E5Q amino acid AbC transporter MUS_2690 ENOG4108HW3 (ABC) transporter MUS_2691 ENOG4108Y6J UPF0403 protein MUS_2692 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) MUS_2693 ENOG4105C7S Dehydrogenase MUS_2694 ENOG4105CPP Dehydrogenase, E1 component MUS_2697 ENOG4105CKM Branched-chain carboxylic acid kinase MUS_2698 ENOG4107RDP Dehydrogenase MUS_2700 ENOG4108JUB Transcriptional regulator MUS_2701 ENOG4106CCJ Protein of unknown function (DUF2627) MUS_2702 ENOG4105CR4 methylisocitrate lyase MUS_2703 ENOG4105DXD 2-methylcitrate dehydratase MUS_2705 ENOG4105C1G acyl-Coa dehydrogenase MUS_2706 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MUS_2708 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MUS_2709 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MUS_2715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MUS_2718 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MUS_2719 ENOG4107QQR Sporulation MUS_2720 ENOG4105S1Z Stage IV sporulation protein B MUS_2721 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) MUS_2722 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) MUS_2723 ENOG4105DX0 Hemolysin A MUS_2724 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) MUS_2725 ENOG4105CTB Polyprenyl synthetase MUS_2726 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) MUS_2727 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) MUS_2729 ENOG4105M7K Involved in the transcription termination process (By similarity) MUS_2731 ENOG4108ZSR alkaline shock protein MUS_2732 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MUS_2736 ENOG410644B Stage III sporulation protein af MUS_2738 ENOG4105KQ4 Stage iii sporulation protein ad MUS_2739 ENOG4108CQH stage III sporulation protein AC MUS_2740 ENOG4105KR5 Stage iii sporulation protein MUS_2741 ENOG4105CD2 stage iii sporulation protein aa MUS_2743 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) MUS_2744 ENOG4105DC7 peptidase M24 MUS_2746 ENOG4105CBJ Metal-dependent enzyme MUS_2750 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) MUS_2751 ENOG4105WZW rhodanese family MUS_2752 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MUS_2754 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) MUS_2755 ENOG4105C0D helicase MUS_2758 ENOG4108IMY Transcriptional regulator MUS_2760 ENOG4105VFR signal peptidase MUS_2772 ENOG4105C37 (CBS) domain MUS_2776 ENOG4105C5X domain protein MUS_2786 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase MUS_2789 ENOG41068DG YceG-like family MUS_2791 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MUS_2792 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MUS_2793 ENOG4105E2Z phosphate ABC transporter (Permease MUS_2794 ENOG4105C8U phosphate abc transporter MUS_2795 ENOG4105CVA phosphate MUS_2796 ENOG4107RF6 penicillin-binding protein MUS_2798 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MUS_2799 ENOG4105SXS Protein of unknown function (DUF456) MUS_2802 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) MUS_2803 ENOG41063Y9 MUS_2804 ENOG4108U5J '-nucleotidase MUS_2805 ENOG4105N80 Ferric uptake regulator, Fur family MUS_2806 ENOG4108JYZ YitT family MUS_2807 ENOG41069ZM Protein of unknown function (DUF2624) MUS_2808 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) MUS_2811 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) MUS_2812 ENOG4105EGD dinuclear metal center protein, YbgI family MUS_2816 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_2817 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MUS_2818 ENOG4108UPT UPF0178 protein MUS_2819 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) MUS_2821 ENOG4105C38 Glycyl-tRNA synthetase beta subunit MUS_2822 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit MUS_2823 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) MUS_2825 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) MUS_2826 ENOG4105KG3 cytidine deaminase MUS_2827 ENOG4107YR5 Diacylglycerol kinase MUS_2828 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) MUS_2829 ENOG4105CTJ Metal Dependent Phosphohydrolase MUS_2830 ENOG4105C9A Phoh family MUS_2831 ENOG4105EI1 sporulation protein yqfd MUS_2832 ENOG41068P3 sporulation protein YqfC MUS_2834 ENOG4105DI5 UPF0365 protein MUS_2835 ENOG4105F7J membrane-bound serine protease MUS_2836 ENOG4105KTH gatB Yqey MUS_2838 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MUS_2839 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) MUS_2840 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) MUS_2841 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MUS_2842 ENOG4105CFG Acts as a chaperone (By similarity) MUS_2843 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ MUS_2844 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) MUS_2845 ENOG4105CSA Coproporphyrinogen iii oxidase MUS_2846 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) MUS_2848 ENOG4108ZRV stage ii sporulation protein p MUS_2849 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) MUS_2850 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) MUS_2851 ENOG4105TQK DNA polymerase iii, delta' subunit MUS_2853 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 MUS_2854 ENOG4108UK2 deaminase MUS_2855 ENOG4105KQC Competence protein MUS_2857 ENOG4108D32 Methyltransferase MUS_2859 ENOG4108WF2 Metal Dependent Phosphohydrolase MUS_2860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) MUS_2861 ENOG410812S Rna-binding protein MUS_2862 ENOG4105E2X shikimate dehydrogenase MUS_2863 ENOG4105CQW ribosome biogenesis GTPase YqeH MUS_2870 ENOG41080BT SNARE associated Golgi MUS_2873 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_2876 ENOG41086D8 Transcriptional regulator MUS_2877 ENOG4107V2S Transcriptional regulator MUS_2880 ENOG4108SWU Histidine kinase MUS_2881 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_2882 ENOG4105DHF Membrane MUS_2883 ENOG4108UYN gCN5-related N-acetyltransferase MUS_2884 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) MUS_2886 ENOG4108J8C transporter major facilitator family protein MUS_2887 ENOG4108U7W acetyltransferase MUS_2890 ENOG4105DQF Hydrolase MUS_2891 ENOG4108HCJ Hydrolase MUS_2894 ENOG4105DG6 mannose-6-phosphate isomerase MUS_2895 ENOG4105DM4 PTS System MUS_2898 ENOG4108Z66 YbaK ebsC protein MUS_2899 ENOG4107RSM transcriptional regulator MUS_2900 ENOG4105D94 Major Facilitator Superfamily MUS_2901 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MUS_2902 ENOG41082JN Transcriptional regulator MUS_2906 ENOG4105TMB Formate nitrite transporter MUS_2907 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) MUS_2908 ENOG4108JB9 formate dehydrogenase MUS_2917 ENOG4107XRG penicillin-binding protein MUS_2918 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) MUS_2926 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MUS_2931 ENOG41068G1 MUS_2934 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj MUS_2938 ENOG4108FKH Transglycosylase SLT domain MUS_2964 ENOG410682Q Phage transcriptional regulator, ArpU MUS_2991 ENOG4105CFP Peptidase U32 MUS_2992 ENOG4105XYU peptidase (U32 family) MUS_2993 ENOG4108VQJ O-methyltransferase MUS_2994 ENOG4105HHA aminodeoxychorismate lyase MUS_2996 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) MUS_2997 ENOG4105VBH UPF0297 protein MUS_2998 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MUS_2999 ENOG4105C02 permease MUS_3000 ENOG4105CDA abc transporter atp-binding protein MUS_3001 ENOG4105CT1 (ABC) transporter MUS_3002 ENOG4105EAD ABC transporter MUS_3003 ENOG4105DRP amino acid AbC transporter MUS_3005 ENOG41060CR MUS_3007 ENOG4105C7H Helicase, RecD TraA family MUS_3010 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) MUS_3011 ENOG4105C3J Cysteine desulfurase MUS_3013 ENOG4105D1H recombination factor protein RarA MUS_3015 ENOG4105CUZ uba thif-type nad fad binding protein MUS_3017 ENOG4105C9M aspartyl-trna synthetase MUS_3018 ENOG4105CUT histidyl-tRNA synthetase MUS_3021 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MUS_3022 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) MUS_3023 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MUS_3025 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) MUS_3026 ENOG41067VP Protein of unknown function (DUF1049) MUS_3027 ENOG4105NCW Trka-c domain protein MUS_3029 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MUS_3031 ENOG4105CKP Polysaccharide Biosynthesis Protein MUS_3034 ENOG4108QG2 Membrane MUS_3035 ENOG4105NAP MUS_3036 ENOG4105VIE preprotein translocase, subunit YajC MUS_3037 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) MUS_3038 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) MUS_3039 ENOG41061AI Protein of unknown function (DUF2905) MUS_3040 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) MUS_3041 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) MUS_3045 ENOG4106678 morphogenetic protein associated with SpoVID MUS_3046 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) MUS_3047 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase MUS_3048 ENOG4108IYU L-aspartate oxidase MUS_3051 ENOG4105CQC Prephenate dehydratase MUS_3053 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control MUS_3055 ENOG4105K46 50S ribosomal protein l27 MUS_3056 ENOG4105X36 (ribosomal) protein MUS_3057 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) MUS_3060 ENOG4107QMS site-determining protein MUS_3061 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) MUS_3062 ENOG4105YHC Rod shape-determining protein MreD MUS_3063 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) MUS_3064 ENOG4105DFF Rod shape-determining protein mreb MUS_3065 ENOG4105W5Q DNA repair protein (RadC MUS_3066 ENOG4108Z03 MAF-like protein MUS_3068 ENOG4106A3R peptidase MUS_3069 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MUS_3070 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) MUS_3073 ENOG4106AR7 Spore coat protein MUS_3074 ENOG41068KH stage VI sporulation protein D MUS_3077 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase MUS_3078 ENOG4105D52 delta-aminolevulinic acid dehydratase MUS_3080 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) MUS_3082 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) MUS_3084 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) MUS_3085 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) MUS_3086 ENOG4108IUQ atp-dependent protease MUS_3087 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) MUS_3088 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation MUS_3091 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MUS_3092 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MUS_3093 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) MUS_3095 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MUS_3096 ENOG4108ZP8 Acetolactate synthase small subunit MUS_3097 ENOG4105C7K acetolactate synthase MUS_3105 ENOG4107SCJ type I restriction enzyme EcoKI subunit R MUS_3108 ENOG4105M59 Phosphodiesterase, mj0936 family MUS_3109 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MUS_3110 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) MUS_3111 ENOG4108XJQ germination protein MUS_3112 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) MUS_3113 ENOG41067TZ transcriptional regulator, MarR family MUS_3114 ENOG4105PFC Transcriptional regulator MUS_3116 ENOG4105E33 succinate dehydrogenase MUS_3118 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit MUS_3120 ENOG4105CFH Aspartokinase MUS_3121 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MUS_3122 ENOG4105K63 Thioredoxin MUS_3124 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) MUS_3125 ENOG4105C10 Electron transfer flavoprotein MUS_3126 ENOG4105BZJ Electron transfer flavoprotein MUS_3127 ENOG41060WC Enoyl-CoA hydratase MUS_3128 ENOG4107Z3H Transcriptional regulator, TetR family MUS_3129 ENOG4105CEY Amp-dependent synthetase and ligase MUS_3132 ENOG4105C98 muts2 protein MUS_3133 ENOG4105DCG PHP domain protein MUS_3136 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) MUS_3137 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MUS_3138 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) MUS_3140 ENOG4108RWN rrna methyltransferase MUS_3141 ENOG41067MF small acid-soluble spore protein MUS_3143 ENOG4105CQB FAD linked oxidase domain protein MUS_3144 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MUS_3147 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) MUS_3148 ENOG4105DRS transport system, permease MUS_3151 ENOG4108MDK Dehydrogenase MUS_3153 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase MUS_3154 ENOG4105EF1 ribulokinase MUS_3156 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase MUS_3159 ENOG4105CN9 Peptidase m42 family protein MUS_3161 ENOG410696E Membrane MUS_3162 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) MUS_3163 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) MUS_3164 ENOG41067MG lrgb family MUS_3166 ENOG4105DY9 regulatoR MUS_3167 ENOG4108HRK Histidine kinase MUS_3168 ENOG4105U0R haloacid dehalogenase-like hydrolase MUS_3169 ENOG4105C22 threonyL-tRNA synthetase MUS_3170 ENOG4108TDW sporulation protein YtxC MUS_3176 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) MUS_3177 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MUS_3178 ENOG4105KVH Transcriptional regulator MUS_3179 ENOG4105F27 Major Facilitator MUS_3180 ENOG4105CV8 reductase MUS_3181 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) MUS_3183 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MUS_3184 ENOG4105C2M dna polymerase I MUS_3186 ENOG4105BZU Histidine kinase MUS_3187 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_3189 ENOG4108HMX isocitrate dehydrogenase (NADP) MUS_3190 ENOG4105BZN citrate synthase MUS_3196 ENOG4108REF Sporulation integral membrane protein ytvi MUS_3197 ENOG4105FS0 cytoplasmic membrane protein MUS_3198 ENOG4105CA9 Pyruvate kinase MUS_3199 ENOG4105CTQ phosphohexokinase MUS_3200 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) MUS_3201 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) MUS_3203 ENOG4105C6K Malic enzyme MUS_3204 ENOG4105C0B DNA polymerase III (alpha subunit) MUS_3205 ENOG4105VV2 MUS_3207 ENOG4106EVM MUS_3208 ENOG4105SFS phosphoesterase RecJ domain protein MUS_3211 ENOG4105E8R UPF0173 metal-dependent hydrolase MUS_3214 ENOG4105CH7 arginosuccinase MUS_3215 ENOG4105CDH Citrulline--aspartate ligase MUS_3216 ENOG4105EPU Molybdenum cofactor synthesis domain protein MUS_3217 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MUS_3219 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) MUS_3220 ENOG4105KBJ sporulation protein ytfj MUS_3222 ENOG4105VK3 rdd domain containing protein MUS_3223 ENOG4105D07 Signal peptide peptidase, SppA MUS_3224 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) MUS_3225 ENOG4105EFZ amidohydrolase MUS_3226 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MUS_3228 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) MUS_3234 ENOG4105U5Y Transcriptional regulator MUS_3237 ENOG4105BZU Histidine kinase MUS_3239 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) MUS_3240 ENOG4105C26 Dehydrogenase MUS_3248 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MUS_3250 ENOG4108Z0Z intracellular protease Pfpi family MUS_3254 ENOG4108NGU Transcriptional regulator MUS_3259 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MUS_3262 ENOG4105F1V Acetoin utilization protein MUS_3263 ENOG4105W87 Cbs domain MUS_3264 ENOG4105DGU Histone deacetylase MUS_3265 ENOG4105ER2 Ompa motb domain protein MUS_3266 ENOG4107R0U MotA TolQ exbB proton channel MUS_3267 ENOG4105ETE Transcriptional regulator (LacI family MUS_3268 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase MUS_3272 ENOG4105DFU Cell wall formation (By similarity) MUS_3274 ENOG4108VDD TRNA binding domain protein MUS_3277 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ MUS_3281 ENOG4105C6K Malic enzyme MUS_3282 ENOG4105C8F Beta-lactamase domain protein MUS_3283 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) MUS_3285 ENOG4108V15 phosphotransferase enzyme family MUS_3288 ENOG4107F58 2'-5' rna ligase MUS_3289 ENOG4105C6T cysteine synthase MUS_3290 ENOG4107QSE Dipeptidase MUS_3291 ENOG4105C7N Xanthine uracil vitamin C permease MUS_3298 ENOG4105CBX hi0933 family MUS_3299 ENOG4105C94 Transporter MUS_3304 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component MUS_3305 ENOG4105I1K ABC transporter MUS_3308 ENOG41085GJ domain protein MUS_3309 ENOG4105C8T Leucyl-tRNA synthetase MUS_3312 ENOG4105BZU Histidine kinase MUS_3313 ENOG410605W Major Facilitator MUS_3318 ENOG4105C19 ABC transporter MUS_3319 ENOG4105EWM Histidine kinase MUS_3321 ENOG4107R34 abc transporter permease protein MUS_3322 ENOG4105C19 ABC transporter MUS_3326 ENOG4105DVE abc transporter atp-binding protein MUS_3327 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MUS_3331 ENOG4105N5T Radical SAM Protein MUS_3334 ENOG4107VXM glycerophosphoryl diester phosphodiesterase MUS_3336 ENOG4105E8V Alpha Beta Hydrolase Fold protein MUS_3337 ENOG4108Z0R Transferase MUS_3339 ENOG4105C85 amino acid MUS_3340 ENOG4105CAQ asparagine synthetase MUS_3341 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP MUS_3342 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase MUS_3345 ENOG4105D2X ABC transporter substrate-binding protein MUS_3347 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component MUS_3350 ENOG4108RMU ferritin dps family protein MUS_3353 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) MUS_3354 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) MUS_3355 ENOG4108V2W Carbonate dehydratase MUS_3356 ENOG4105NRA 50s ribosomal protein l31 type b MUS_3360 ENOG4105CC5 ABC transporter MUS_3361 ENOG4105CC5 ABC transporter MUS_3362 ENOG4105DIK (ABC) transporter MUS_3363 ENOG4105DSE periplasmic solute binding protein MUS_3365 ENOG4105DTQ mandelate racemase muconate lactonizing MUS_3366 ENOG4105CEY Amp-dependent synthetase and ligase MUS_3367 ENOG4108IPT Naphthoate synthase MUS_3368 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) MUS_3369 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) MUS_3370 ENOG4105E4F Isochorismate synthase MUS_3378 ENOG4105N67 Proton-coupled thiamine transporter YuaJ MUS_3379 ENOG4105DZ6 Band 7 protein MUS_3381 ENOG4106DF1 MUS_3382 ENOG4108VNY MOSC domain protein MUS_3383 ENOG4108JB8 alcohol dehydrogenase MUS_3384 ENOG4105C26 Dehydrogenase MUS_3385 ENOG4105TRT Transcriptional regulator MUS_3388 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj MUS_3390 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) MUS_3394 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MUS_3396 ENOG4105EE0 oxidoreductase MUS_3397 ENOG4108Z0Z intracellular protease Pfpi family MUS_3398 ENOG4105C8Q Methyl-accepting chemotaxis MUS_3399 ENOG4105C8Q Methyl-accepting chemotaxis MUS_3400 ENOG4105C8Q Methyl-accepting chemotaxis MUS_3405 ENOG4105C8Q Methyl-accepting chemotaxis MUS_3408 ENOG4105EA8 2-Nitropropane dioxygenase MUS_3409 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme MUS_3413 ENOG4105C37 (CBS) domain MUS_3417 ENOG4107PBV potassium channel MUS_3418 ENOG4107PBV potassium channel MUS_3421 ENOG4107QYV phosphohexose isomerase MUS_3425 ENOG4105CHJ isochorismatase hydrolase MUS_3427 ENOG4107QW4 alcohol dehydrogenase MUS_3428 ENOG4105WG9 Conserved Protein MUS_3430 ENOG4105CHM Aminotransferase MUS_3431 ENOG4108ZB6 transcriptional regulator AsnC family MUS_3432 ENOG4108MUZ hydrolase MUS_3434 ENOG4105C87 Aminotransferase class I and II MUS_3436 ENOG4108HGU Histidine kinase MUS_3437 ENOG4105Y38 Kinase-associated protein B MUS_3441 ENOG4105BZ4 penicillin-binding protein MUS_3442 ENOG4105KIR Thiol-disulfide oxidoreductase dcc MUS_3445 ENOG4108MRH transcriptional regulatory protein MUS_3447 ENOG4105DIH basic membrane MUS_3449 ENOG4108JQ9 ABC transporter MUS_3450 ENOG4105UIB (ABC) transporter MUS_3453 ENOG4105D65 subunit l MUS_3454 ENOG4105HC0 Na H antiporter MUS_3455 ENOG4108ZE9 Monovalent cation H antiporter subunit C MUS_3456 ENOG4108JPZ Monovalent cation H antiporter subunit D MUS_3457 ENOG4105SC1 monovalent cation H antiporter subunit E MUS_3459 ENOG4105KJM monovalent cation h antiporter subunit g MUS_3460 ENOG4105KA0 thioesterase Superfamily protein MUS_3462 ENOG4105BZU Histidine kinase MUS_3467 ENOG4105D58 Diguanylate phosphodiesterase MUS_3468 ENOG4105DAP Nicotinate phosphoribosyltransferase MUS_3473 ENOG4105C02 permease MUS_3476 ENOG410904N short-chain dehydrogenase reductase MUS_3484 ENOG4108K8K Transcriptional regulator MUS_3485 ENOG4105DCF alanine dehydrogenase MUS_3487 ENOG4105WQT MbtH domain protein MUS_3488 ENOG4105CEY Amp-dependent synthetase and ligase MUS_3489 ENOG4105WQI isochorismatase MUS_3490 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MUS_3491 ENOG4105E4F Isochorismate synthase MUS_3492 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase MUS_3493 ENOG4105NIV Esterase MUS_3498 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) MUS_3500 ENOG41069ER domain protein MUS_3503 ENOG4105CEP NADH dehydrogenase MUS_3507 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) MUS_3510 ENOG4105CJ1 ABC, transporter MUS_3514 ENOG4105D9U N-acetyltransferase MUS_3515 ENOG4108VHC Short-chain dehydrogenase reductase Sdr MUS_3516 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) MUS_3519 ENOG4105ZKE UPF0349 protein MUS_3522 ENOG41083MR nifu domain-containing protein MUS_3523 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein MUS_3524 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) MUS_3525 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) MUS_3526 ENOG4105D6E homoserine dehydrogenase MUS_3528 ENOG4108W5N phosphatidylglycerophosphatase a MUS_3529 ENOG4105D4U had-superfamily hydrolase, subfamily iia MUS_3532 ENOG4105MMD transcriptional regulator MUS_3533 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) MUS_3534 ENOG4105FAA peptidase M23 MUS_3535 ENOG4107R8B 5'-nucleotidase MUS_3537 ENOG4105I3N Conserved Protein MUS_3539 ENOG4105CD3 dihydroorotase MUS_3540 ENOG4105G9B Transcriptional regulator MUS_3546 ENOG4105C5R Aminotransferase MUS_3548 ENOG4108K8S endonuclease I MUS_3549 ENOG4108IJ9 (ABC) transporter MUS_3550 ENOG4105FDP GntR family transcriptional regulator MUS_3551 ENOG4108KPW sugar kinase MUS_3552 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component MUS_3553 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component MUS_3554 ENOG4105XN3 extracellular solute-binding protein family 1 MUS_3555 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine MUS_3561 ENOG4105PKS Excinuclease abc c subunit domain protein MUS_3562 ENOG4107VFR oxidoreductase MUS_3567 ENOG41083Q9 chitosanase MUS_3568 ENOG4105DIW FeS assembly protein SUFB MUS_3569 ENOG4108UNV SUF system FeS assembly protein, NifU family MUS_3570 ENOG4105C9B Cysteine desulfurase MUS_3571 ENOG4105JRK feS assembly protein SufD MUS_3572 ENOG4105C3K feS assembly ATPase SufC MUS_3575 ENOG4105D01 (LipO)protein MUS_3576 ENOG4108UMI ABC transporter, permease MUS_3578 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) MUS_3583 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) MUS_3584 ENOG41080E8 Transcriptional regulator, Spx MgsR family MUS_3585 ENOG4105C1G acyl-Coa dehydrogenase MUS_3586 ENOG4105CHU acetyl-coa acetyltransferase MUS_3592 ENOG41067TZ transcriptional regulator, MarR family MUS_3593 ENOG4105C0R drug resistance transporter emrb qaca subfamily MUS_3594 ENOG4105C5Q Transcriptional regulator MUS_3598 ENOG4105E0A ABC, transporter MUS_3601 ENOG4105E1F short-chain dehydrogenase reductase MUS_3602 ENOG4105HUF DNA protection during starvation protein MUS_3606 ENOG4105F3H Histidine kinase MUS_3608 ENOG41067SE Tetr family transcriptional regulator MUS_3609 ENOG4105C9Q fumarate hydratase class II MUS_3614 ENOG4105WH1 Two component transcriptional regulator luxr family MUS_3615 ENOG4105ENE Histidine kinase MUS_3618 ENOG41087YS Phage shock protein A MUS_3621 ENOG4108WBT adenosyltransferase MUS_3622 ENOG4105E0A ABC, transporter MUS_3623 ENOG4105EHG Permease protein MUS_3624 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) MUS_3625 ENOG4105EWI Short-chain dehydrogenase reductase Sdr MUS_3626 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein MUS_3628 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_3631 ENOG4106DF4 Sigma-70, region 4 MUS_3634 ENOG4105F0F Oxalate decarboxylase MUS_3636 ENOG4105E0A ABC, transporter MUS_3637 ENOG4105EHG Permease protein MUS_3638 ENOG4105DQ5 transport system permease protein MUS_3641 ENOG4105JQZ Methyltransferase MUS_3642 ENOG4105D5Q Arginine ornithine antiporter MUS_3644 ENOG4107K5X Membrane-bound metal-dependent hydrolase MUS_3645 ENOG4107QZ2 Sulfatase MUS_3646 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family MUS_3647 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein MUS_3648 ENOG4105E0C molybdate abc transporter MUS_3649 ENOG4105WH1 Two component transcriptional regulator luxr family MUS_3650 ENOG4105BZU Histidine kinase MUS_3651 ENOG4105CJ1 ABC, transporter MUS_3653 ENOG4108KYE ABC-2 type transporter MUS_3656 ENOG4105EEQ Na H antiporter MUS_3658 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) MUS_3659 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MUS_3660 ENOG4105EEM helicase MUS_3662 ENOG4105EN6 Membrane MUS_3665 ENOG4107ZQN disulfide bond MUS_3666 ENOG4105C59 p-type ATPase MUS_3667 ENOG4105C59 p-type ATPase MUS_3670 ENOG410681U heavy metal transport detoxification protein MUS_3671 ENOG4105VPX protein, conserved in bacteria MUS_3672 ENOG4105D9R oxidoreductase MUS_3673 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) MUS_3676 ENOG4105DEN Luciferase family MUS_3677 ENOG4105CDA abc transporter atp-binding protein MUS_3682 ENOG4108XSB acetyltransferase, (GNAT) family MUS_3683 ENOG4108KSA LysR family transcriptional regulator MUS_3684 ENOG4105EWI Short-chain dehydrogenase reductase Sdr MUS_3685 ENOG41067XF inhibitor MUS_3687 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) MUS_3688 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) MUS_3690 ENOG4105XZU Preprotein translocase, subunit SecG MUS_3694 ENOG4105KVH Transcriptional regulator MUS_3700 ENOG4105DA5 (ABC) transporter MUS_3703 ENOG4108HQR Glycine betaine MUS_3704 ENOG4105E90 ABC transporter MUS_3705 ENOG4108IJ8 ABC transporter MUS_3707 ENOG4107HG4 Transcriptional regulator MUS_3709 ENOG4105R40 Glycine betaine carnitine choline MUS_3710 ENOG4108HQR Glycine betaine MUS_3711 ENOG4105E90 ABC transporter MUS_3712 ENOG4108IJ8 ABC transporter MUS_3713 ENOG4107HG4 Transcriptional regulator MUS_3715 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein MUS_3718 ENOG4105T65 Membrane-associated protein MUS_3719 ENOG4108W0I acetyltransferase MUS_3720 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) MUS_3721 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) MUS_3722 ENOG4105CP7 Triose-phosphate isomerase MUS_3723 ENOG4105BZA Phosphoglycerate kinase MUS_3725 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MUS_3728 ENOG4105CMD Transcriptional regulator, GntR family MUS_3729 ENOG4105DEN Luciferase family MUS_3730 ENOG4105GZI Transcriptional regulator MUS_3731 ENOG4107RT3 EamA-like transporter family MUS_3737 ENOG4106KNT transcriptional regulator MUS_3738 ENOG4105CMG Carbohydrate kinase MUS_3739 ENOG4105C6Z Gluconate MUS_3742 ENOG4107QR9 Iron-sulfur cluster binding protein MUS_3743 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MUS_3744 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MUS_3745 ENOG4105JXH GntR family transcriptional regulator MUS_3746 ENOG4105DAA L-lactate MUS_3747 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MUS_3749 ENOG4108ZPC Polysaccharide pyruvyl transferase MUS_3751 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MUS_3753 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family MUS_3754 ENOG4105D3Q Sugar transferase MUS_3756 ENOG4105K64 Glycosyl transferase, family 2 MUS_3758 ENOG4107QRS glycosyltransferase group 2 family protein MUS_3759 ENOG41068W6 Capsular polysaccharide biosynthesis protein MUS_3760 ENOG4108KMV Glycosyl transferase (Group 1 MUS_3762 ENOG4105K64 Glycosyl transferase, family 2 MUS_3763 ENOG4108PQP glycosyl transferase group 1 MUS_3765 ENOG4108QV3 biosynthesis protein MUS_3766 ENOG4105HTX biosynthesis protein MUS_3768 ENOG4105EBR Carboxylesterase MUS_3771 ENOG4105NAE bifunctional deaminase-reductase domain protein MUS_3773 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 MUS_3774 ENOG4105PY6 Phenolic acid decarboxylase MUS_3775 ENOG4105NI3 Protein of unknown function (DUF3237) MUS_3786 ENOG4108HKT sucrose-6-phosphate hydrolase MUS_3787 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) MUS_3789 ENOG4105ETE Transcriptional regulator (LacI family MUS_3791 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MUS_3792 ENOG4107URF beta-phospho-glucomutase MUS_3794 ENOG4105CG3 alpha amylase, catalytic region MUS_3797 ENOG4105EG2 ABC transporter, permease MUS_3798 ENOG4105D56 permease protein MUS_3800 ENOG4107FKK extracellular solute-binding protein family 1 MUS_3801 ENOG4108IUK alpha amylase, catalytic MUS_3802 ENOG4105FKQ transcriptional regulator MUS_3803 ENOG4108URH decarboxylase MUS_3804 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain MUS_3805 ENOG4105CHH sulfate transporter MUS_3806 ENOG4108V2W Carbonate dehydratase MUS_3808 ENOG4105C5I Dehydrogenase MUS_3809 ENOG4105GGE ribonuclease MUS_3810 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase MUS_3811 ENOG4105KRI phosphocarrier protein (HPr MUS_3812 ENOG4105CIE May be required for sporulation (By similarity) MUS_3813 ENOG4105CHW UPF0052 protein MUS_3814 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) MUS_3815 ENOG4108Z4K mutator MutT protein MUS_3817 ENOG4105C3M thioredoxin reductase MUS_3821 ENOG4105BZU Histidine kinase MUS_3822 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MUS_3823 ENOG4105GIG MUS_3824 ENOG4105BZ1 (ABC) transporter MUS_3825 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase MUS_3826 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) MUS_3827 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase MUS_3828 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) MUS_3829 ENOG4105ECC imidazole-glycerol-phosphate dehydratase MUS_3830 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) MUS_3831 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) MUS_3832 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) MUS_3834 ENOG4108S4C acetyltransferase MUS_3835 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MUS_3837 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) MUS_3838 ENOG4105CE4 GlcNAc 6-P deacetylase MUS_3839 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) MUS_3840 ENOG4105FDP GntR family transcriptional regulator MUS_3841 ENOG4105J7D transcriptional regulator MUS_3842 ENOG41088CQ domain protein MUS_3843 ENOG41086DT Membrane protein of unknown function MUS_3844 ENOG41067S9 phage shock protein C, PspC MUS_3845 ENOG4108PY7 MUS_3848 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MUS_3849 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) MUS_3852 ENOG4105MKU Transcriptional regulator MUS_3863 ENOG4105CHR reductase MUS_3866 ENOG4105CN1 protease MUS_3867 ENOG4108M26 parallel beta-helix repeat protein MUS_3868 ENOG4105CRP Part of the ABC transporter FtsEX involved in MUS_3869 ENOG4105CAK Cell division ATP-binding protein ftsE MUS_3872 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) MUS_3873 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving MUS_3874 ENOG4105MS2 ribosomal subunit Interface protein MUS_3877 ENOG4105MQ3 flagellar protein FliS MUS_3878 ENOG4107RT6 flagellar hook-associated MUS_3879 ENOG4105I03 Flagellin MUS_3880 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) MUS_3881 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) MUS_3883 ENOG4105DTJ flagellar hook-associated protein MUS_3884 ENOG4105E1Q flagellar hook-associated protein MUS_3887 ENOG4105RU3 MUS_3888 ENOG41081UC Inherit from COG: Competence protein MUS_3892 ENOG4105WH1 Two component transcriptional regulator luxr family MUS_3893 ENOG4105BZU Histidine kinase MUS_3894 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein MUS_3895 ENOG4108KGH TRANSCRIPTIONal MUS_3896 ENOG4105ESV Glycosyl transferase, family 4 MUS_3897 ENOG4107EF8 Glycosyl transferase (Group 1 MUS_3900 ENOG4105QZI O-Antigen Polymerase MUS_3901 ENOG4105C6Y Udp-glucose 6-dehydrogenase MUS_3902 ENOG4107RA4 Glycosyl transferase (Group 1 MUS_3903 ENOG4105PSV Polysaccharide Biosynthesis Protein MUS_3904 ENOG4105D3Q Sugar transferase MUS_3905 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MUS_3906 ENOG4105JFG SpoIID LytB domain protein MUS_3909 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase MUS_3910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MUS_3911 ENOG4105EY8 ABC transporter MUS_3913 ENOG4107SJB teichoic acid biosynthesis MUS_3915 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase MUS_3917 ENOG4107RZX Teichoic acid biosynthesis protein MUS_3919 ENOG4105DG6 mannose-6-phosphate isomerase MUS_3923 ENOG4108NHD germination protein MUS_3924 ENOG4107R8N Glycosyl transferase, family 2 MUS_3925 ENOG4105C54 Major Facilitator superfamily MUS_3927 ENOG4108KGH TRANSCRIPTIONal MUS_3928 ENOG4105J7I hydrolase MUS_3929 ENOG4106UBQ MUS_3930 ENOG4105K4H Nlp p60 protein MUS_3933 ENOG4105PNM synthesis protein MUS_3935 ENOG4105N98 Capsule biosynthesis protein capB MUS_3939 ENOG4105E1K spore germination protein MUS_3942 ENOG4105ETE Transcriptional regulator (LacI family MUS_3943 ENOG4108RVA ribokinase MUS_3944 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) MUS_3945 ENOG4105C2J ABC transporter MUS_3946 ENOG4105CNN ABC, transporter MUS_3947 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator MUS_3950 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein MUS_3951 ENOG4107FQX Alpha-acetolactate decarboxylase MUS_3953 ENOG4107RSM transcriptional regulator MUS_3958 ENOG4106UIA MUS_3963 ENOG4107XC4 flavin reductase domain protein, FMN-binding MUS_3967 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) MUS_3970 ENOG4105FGV Chromate MUS_3973 ENOG4108WS4 fmn reductase MUS_3974 ENOG4107V2S Transcriptional regulator MUS_3975 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) MUS_3986 ENOG4108XI2 Domain of unknown function (DUF1963) MUS_3987 ENOG4105C6Y Udp-glucose 6-dehydrogenase MUS_3989 ENOG4108RB3 Capsular polysaccharide biosynthesis protein MUS_3990 ENOG4107YJ4 chain length determinant protein MUS_3991 ENOG4105HTX biosynthesis protein MUS_3994 ENOG4105KBK Zinc finger, swim domain protein MUS_3995 ENOG4105C0D helicase MUS_3996 ENOG410667J hydrolase MUS_3997 ENOG4105E98 transcriptional regulator DeoR family MUS_3999 ENOG4105Z8H single-stranded DNA-binding protein MUS_4002 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) MUS_4003 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) MUS_4005 ENOG4105CGA flagellar basal-body rod protein FlgG MUS_4008 ENOG4105DFF Rod shape-determining protein mreb MUS_4009 ENOG4105MT0 Sporulation transcriptional regulator spoiiid MUS_4010 ENOG4107MII Sugar-specific transcriptional regulator TrmB MUS_4011 ENOG4105CZM Major Facilitator MUS_4012 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease MUS_4013 ENOG41080V3 Major Facilitator superfamily MUS_4014 ENOG4105D3W isochorismatase MUS_4016 ENOG4105BZU Histidine kinase MUS_4018 ENOG4105CNI cell division protein FtsW MUS_4019 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase MUS_4021 ENOG4105FRN stage II sporulation protein MUS_4022 ENOG4107TCE N-acetyltransferase MUS_4026 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MUS_4027 ENOG4106BRK MUS_4029 ENOG4108Z40 Transcriptional regulator MUS_4030 ENOG4105CQM Urea amidohydrolase subunit alpha MUS_4031 ENOG4105KI2 Urea amidohydrolase subunit beta MUS_4032 ENOG4108YZ9 Urea amidohydrolase subunit gamma MUS_4037 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MUS_4038 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MUS_4040 ENOG4108TF4 von Willebrand factor, type A MUS_4045 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MUS_4047 ENOG4106778 Protein of unknown function (DUF1146) MUS_4049 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) MUS_4050 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) MUS_4051 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) MUS_4052 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) MUS_4053 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) MUS_4056 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) MUS_4059 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) MUS_4060 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) MUS_4062 ENOG4108UIC UPF0340 protein MUS_4064 ENOG4107WAU Protein tyrosine phosphatase MUS_4065 ENOG410815N Probably functions as a manganese efflux pump (By similarity) MUS_4067 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MUS_4069 ENOG4108ZXQ stage ii sporulation protein r MUS_4076 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) MUS_4077 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MUS_4079 ENOG4107TT2 Auxin Efflux Carrier MUS_4080 ENOG4105C6K Malic enzyme MUS_4081 ENOG4107104 thymidine kinase MUS_4082 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) MUS_4084 ENOG4105CBT Fructose-1,6-bisphosphatase MUS_4085 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MUS_4087 ENOG4105D2N Aldolase MUS_4088 ENOG410812K response regulator receiver protein MUS_4090 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) MUS_4093 ENOG4105DF6 Fe-S oxidoreductase MUS_4097 ENOG4105E5J UV damage endonuclease MUS_4099 ENOG4105BZ1 (ABC) transporter MUS_4100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MUS_4103 ENOG4105R3A Nitrate reductase MUS_4104 ENOG4108IUE nitrate reductase beta subunit MUS_4108 ENOG4107V6Q Cyclic nucleotide-binding domain MUS_4110 ENOG4105C75 arginyL-tRNA synthetase MUS_4111 ENOG410684U Domain of unknown function (DUF1934) MUS_4113 ENOG4107JM4 Tetratricopeptide repeat MUS_4119 ENOG4105CYW agmatinase MUS_4120 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) MUS_4121 ENOG4105BZ4 penicillin-binding protein MUS_4123 ENOG4108XFG YwhD family MUS_4124 ENOG4108Z4T Peptidase M50 MUS_4125 ENOG41069HH 4-oxalocrotonate tautomerase MUS_4126 ENOG41067TZ transcriptional regulator, MarR family MUS_4127 ENOG4105CUB amino acid MUS_4129 ENOG4105DCI Phosphohydrolase MUS_4132 ENOG4108VCI transcription factor, rsfa family MUS_4133 ENOG4105K7K Transcriptional regulator MUS_4135 ENOG4105CJ1 ABC, transporter MUS_4136 ENOG4108TU7 Inherit from COG: (ABC) transporter MUS_4141 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) MUS_4142 ENOG4105DUM transcriptional regulator, lysR family MUS_4143 ENOG4105HMI Membrane MUS_4144 ENOG4108IJ2 phosphate acetyltransferase MUS_4145 ENOG4107JTW chlorite dismutase MUS_4147 ENOG4105CHM Aminotransferase MUS_4153 ENOG4105FCW Major Facilitator superfamily MUS_4154 ENOG4105C2C drug resistance transporter, Bcr CflA MUS_4158 ENOG4105C26 Dehydrogenase MUS_4160 ENOG4105D82 Glutamate dehydrogenase MUS_4162 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_4166 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase MUS_4167 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase MUS_4168 ENOG4105C1B dTDP-glucose 4-6-dehydratase MUS_4169 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) MUS_4170 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG MUS_4171 ENOG4107TY6 Acylneuraminate cytidylyltransferase MUS_4173 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD MUS_4174 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MUS_4184 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) MUS_4185 ENOG4108RJ9 Glycosyl transferase, family 2 MUS_4189 ENOG4105DWF phosphomethylpyrimidine kinase MUS_4192 ENOG4105C5Y PTS System MUS_4195 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MUS_4196 ENOG4105DEN Luciferase family MUS_4197 ENOG4108DBC nitroreductase MUS_4199 ENOG4105I4A GCN5-related N-acetyltransferase MUS_4203 ENOG4105BZ9 Cytochrome C oxidase, subunit I MUS_4204 ENOG4105E2S oxidase) subunit II MUS_4205 ENOG4107BMA Transglycosylase associated protein MUS_4211 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) MUS_4212 ENOG4105WH5 Teichoic acid glycosylation protein MUS_4217 ENOG4107ZXU DSBA oxidoreductase MUS_4218 ENOG4105DBE peroxidase MUS_4219 ENOG410650H (LipO)protein MUS_4220 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) MUS_4221 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase MUS_4222 ENOG4105CMU LysR family (Transcriptional regulator MUS_4223 ENOG4105VAW lrga family MUS_4224 ENOG41067MG lrgb family MUS_4226 ENOG4107TXC Transcriptional regulator MUS_4230 ENOG4105DR4 Methyltransferase MUS_4231 ENOG4105CK1 PTS System MUS_4234 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin MUS_4235 ENOG4105X1N Glycosyl transferase family 8 MUS_4238 ENOG4105GVJ transcriptional regulator MUS_4239 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MUS_4242 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MUS_4244 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) MUS_4245 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MUS_4246 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) MUS_4247 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD MUS_4248 ENOG4105CM2 brancheD-chain amino acid aminotransferase MUS_4249 ENOG4105F8D glycoside hydrolase family 4 MUS_4250 ENOG4105VCP PTS System MUS_4251 ENOG4105CK1 PTS System MUS_4252 ENOG4105VZJ PTS System MUS_4253 ENOG4105EMD TRANSCRIPTIONal MUS_4256 ENOG4105DQ5 transport system permease protein MUS_4258 ENOG4105EHG Permease protein MUS_4260 ENOG41082YX Transcriptional regulator, arsr family MUS_4261 ENOG4107R5R arsenical pump membrane protein MUS_4262 ENOG4105VZJ PTS System MUS_4263 ENOG4105VCP PTS System MUS_4264 ENOG4105CK1 PTS System MUS_4265 ENOG4105CS2 ec 3.2.1.21 MUS_4266 ENOG4105EVU fructokinase MUS_4267 ENOG4105DG6 mannose-6-phosphate isomerase MUS_4269 ENOG4105CH6 catalase MUS_4270 ENOG4107QHE Choloylglycine hydrolase MUS_4272 ENOG4105ETS cytosine purines uracil thiamine allantoin MUS_4273 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) MUS_4274 ENOG4108JJ8 (ABC) transporter MUS_4275 ENOG4108JJ9 ABC, transporter MUS_4276 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MUS_4277 ENOG4105C4M (Ubiquinol oxidase) subunit I MUS_4279 ENOG4105D2K citrate carrier protein MUS_4280 ENOG4107BJW polysaccharide deacetylase MUS_4285 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) MUS_4288 ENOG4105CMR udp-glucose 4-epimerase MUS_4289 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) MUS_4296 ENOG4105DHI Methyltransferase MUS_4302 ENOG4105CH6 catalase MUS_4303 ENOG4105D4T Citrate transporter MUS_4304 ENOG4108RZ2 Glycoside hydrolase family 16 MUS_4305 ENOG4105CID antiterminator MUS_4306 ENOG4105DEU major facilitator superfamily MUS_4307 ENOG4105C1J atp-dependent rna helicase MUS_4318 ENOG4105CNA YD repeat protein MUS_4319 ENOG4108NR7 pectate lyase MUS_4322 ENOG4107YZX Universal stress protein MUS_4324 ENOG4105M6F mutator MutT protein MUS_4326 ENOG4106Z5D Glycoside Hydrolase Family 43 MUS_4328 ENOG4105C84 Histidine ammonia-lyase MUS_4329 ENOG4105CGP Urocanate hydratase MUS_4330 ENOG4105CI2 imidazolone-5-propionate hydrolase MUS_4331 ENOG4107W25 arginase agmatinase formiminoglutamase MUS_4333 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) MUS_4334 ENOG4105D9N nucleoside MUS_4335 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) MUS_4336 ENOG4107RHR regulatoR MUS_4337 ENOG410667J hydrolase MUS_4343 ENOG4108V5C ABC transporter MUS_4350 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_4354 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MUS_4357 ENOG4108JJA ABC, transporter MUS_4359 ENOG4105WZ4 isomerase MUS_4360 ENOG4105F0H myo-inositol catabolism protein MUS_4361 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) MUS_4363 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) MUS_4365 ENOG4105EDK PfkB domain protein MUS_4367 ENOG4105C26 Dehydrogenase MUS_4370 ENOG4105CPC Aldo Keto reductase MUS_4372 ENOG4107QNK )-transporter MUS_4373 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) MUS_4375 ENOG41061TZ Short-chain dehydrogenase reductase Sdr MUS_4376 ENOG4108S01 response regulator MUS_4377 ENOG4108ZGX Histidine kinase MUS_4378 ENOG4105ECK Fatty Acid Desaturase MUS_4380 ENOG4105ST3 Transcriptional regulator MUS_4381 ENOG4105C26 Dehydrogenase MUS_4382 ENOG4108ITS PQQ enzyme repeat MUS_4384 ENOG4105WAB arsR family transcriptional regulator MUS_4385 ENOG4105DP8 Major facilitator superfamily MFS_1 MUS_4386 ENOG41085PJ rdd domain containing protein MUS_4388 ENOG4105D3R alkyl hydroperoxide reductase MUS_4389 ENOG4108JU3 Alkyl hydroperoxide reductase MUS_4390 ENOG4107R3N Filamentation induced by cAMP protein fic MUS_4391 ENOG4105C85 amino acid MUS_4392 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 MUS_4393 ENOG4108XHQ (2Fe-2S)-binding domain protein MUS_4397 ENOG4105XRQ Xanthine dehydrogenase accessory factor MUS_4405 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) MUS_4408 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) MUS_4409 ENOG4105CPC Aldo Keto reductase MUS_4410 ENOG4105WQG acetyltransferase MUS_4413 ENOG41066UZ arginase EC 3.5.3.1 MUS_4414 ENOG4108IQI permease MUS_4415 ENOG4105C8Y Acetylornithine aminotransferase MUS_4416 ENOG4108JUB Transcriptional regulator MUS_4418 ENOG4105C5H ABC transporter MUS_4421 ENOG4105D06 uba thif-type nad fad binding protein MUS_4422 ENOG41062D9 Histidine kinase MUS_4428 ENOG4105C0H protease MUS_4429 ENOG4105Q2H domain protein MUS_4432 ENOG4105BZU Histidine kinase MUS_4433 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MUS_4435 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MUS_4436 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase MUS_4437 ENOG4105CDU Replicative dna helicase MUS_4441 ENOG4105EDW glycosyl transferase, family 39 MUS_4442 ENOG4107QPH glycogen) synthase MUS_4445 ENOG4105CPK Glycosyl transferase (Group 1 MUS_4449 ENOG4105BZR domain protein MUS_4450 ENOG4108XMW Membrane MUS_4453 ENOG4105KVH Transcriptional regulator MUS_4454 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase MUS_4455 ENOG4108UZ3 Transporter MUS_4456 ENOG4105EDQ levansucrase EC 2.4.1.10 MUS_4457 ENOG4108HKT sucrose-6-phosphate hydrolase MUS_4458 ENOG4107XBN GntR Family Transcriptional Regulator MUS_4461 ENOG4106UX7 integral membrane protein MUS_4463 ENOG4108TVJ Nitroreductase MUS_4464 ENOG4105FS7 Transcriptional regulator MUS_4467 ENOG4108U05 Transcriptional regulator MUS_4468 ENOG41082BV acetyltransferase MUS_4470 ENOG4107XGZ Hydrolase MUS_4477 ENOG4107Y9U Membrane MUS_4478 ENOG4105C7Z Conserved Protein MUS_4480 ENOG4107FCW Abortive infection protein MUS_4482 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase MUS_4484 ENOG4105CGK Exodeoxyribonuclease III MUS_4486 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MUS_4488 ENOG4108UUM single-stranded DNA-binding protein MUS_4489 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) MUS_4490 ENOG4105C3G gtp-binding protein MUS_4491 ENOG4108J2R molybdopterin oxidoreductase MUS_4492 ENOG4105VDK protein, conserved in bacteria MUS_4496 ENOG4108ZDA Sporulation protein YyaC MUS_4497 ENOG4105FA0 parb-like partition protein MUS_4498 ENOG4107QJE Chromosome Partitioning Protein MUS_4501 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) MUS_4502 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) MUS_4505 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)