locus-tag class description D2M30_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D2M30_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D2M30_00015 ENOG410848D S4 domain protein YaaA D2M30_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D2M30_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D2M30_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D2M30_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D2M30_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) D2M30_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) D2M30_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D2M30_00095 ENOG4105BZW Glycerate kinase D2M30_00105 ENOG4105ZMH deoxynucleoside kinase D2M30_00115 ENOG4105VRS hydrolase family 18 D2M30_00120 ENOG4105GTG Isochorismatase D2M30_00125 ENOG4108Z6B deaminase D2M30_00135 ENOG4105C6E dna polymerase iii D2M30_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D2M30_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D2M30_00155 ENOG41067KS pro-sigma K processing D2M30_00195 ENOG4105CDW Resistance protein D2M30_00200 ENOG4105CXN decarboxylase D2M30_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D2M30_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II D2M30_00215 ENOG4105XVJ Protein of unknown function (DUF327) D2M30_00220 ENOG4105FA2 dna polymerase iii D2M30_00225 ENOG4105MA4 psp1 domain protein D2M30_00235 ENOG41060K3 Methyltransferase D2M30_00240 ENOG4105VC4 domain protein D2M30_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D2M30_00250 ENOG4105KRN Transcriptional regulator, abrb family D2M30_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D2M30_00260 ENOG4105F8V Hydrolase, tatD family D2M30_00265 ENOG41069ER domain protein D2M30_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D2M30_00280 ENOG4105XFA sporulation peptidase YabG D2M30_00285 ENOG4105W42 Veg protein D2M30_00290 ENOG4105XEW small acid-soluble spore protein D2M30_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D2M30_00300 ENOG4105DFT pur operon repressor D2M30_00305 ENOG4105KME endoribonuclease L-psp D2M30_00310 ENOG4105K4W Could be involved in septation (By similarity) D2M30_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D2M30_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D2M30_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D2M30_00340 ENOG4108JA2 transcriptioN-repair coupling factor D2M30_00345 ENOG4108M14 stage v sporulation protein t D2M30_00360 ENOG41082I2 s4 domain protein D2M30_00365 ENOG4105VYY sporulation protein yabp D2M30_00380 ENOG41060GV RNA binding s1 domain protein D2M30_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D2M30_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase D2M30_00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D2M30_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D2M30_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase D2M30_00440 ENOG4105C6T cysteine synthase D2M30_00445 ENOG4105CRQ synthase (Component I) D2M30_00450 ENOG4105DDQ anthranilate synthase D2M30_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 D2M30_00460 ENOG4105EEI dihydropteroate synthase D2M30_00465 ENOG4105KRF dihydroneopterin aldolase D2M30_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D2M30_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D2M30_00485 ENOG4105CRK lysyL-tRNA synthetase D2M30_00575 ENOG4108Z0C Uvrb UvrC protein D2M30_00580 ENOG41066A3 ATP guanido phosphotransferase D2M30_00590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D2M30_00595 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) D2M30_00600 ENOG4105CTP PilT protein domain protein D2M30_00605 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D2M30_00610 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D2M30_00615 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D2M30_00620 ENOG4105D7W serine acetyltransferase D2M30_00630 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) D2M30_00635 ENOG4105C2N RNA methyltransferase TrmH family group 3 D2M30_00640 ENOG4105M0M Tetracycline resistance protein D2M30_00660 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D2M30_00665 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D2M30_00675 ENOG4108VZM 50s ribosomal protein L10 D2M30_00680 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D2M30_00685 ENOG4107Y49 methyltransferase D2M30_00690 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D2M30_00695 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D2M30_00700 ENOG4105XPM ribosomal protein D2M30_00705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D2M30_00710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D2M30_00715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D2M30_00720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D2M30_00725 ENOG4107SKW Inherit from COG: Alpha beta hydrolase D2M30_00730 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D2M30_00735 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D2M30_00740 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D2M30_00745 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D2M30_00750 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D2M30_00755 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D2M30_00760 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D2M30_00765 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D2M30_00770 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D2M30_00775 ENOG41082SA 50s ribosomal protein l29 D2M30_00780 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D2M30_00785 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D2M30_00795 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D2M30_00805 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D2M30_00810 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D2M30_00815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D2M30_00820 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D2M30_00825 ENOG4105VPB 50S ribosomal protein L30 D2M30_00830 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D2M30_00835 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D2M30_00840 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D2M30_00845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D2M30_00855 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D2M30_00865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D2M30_00870 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D2M30_00875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D2M30_00880 ENOG4108ZT0 50S ribosomal protein l17 D2M30_00885 ENOG4108JJB ABC transporter D2M30_00890 ENOG4108JJB ABC transporter D2M30_00895 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) D2M30_00900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D2M30_00905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D2M30_00910 ENOG4108UJD 30S ribosomal protein S9 D2M30_00915 ENOG4108I0C methyltransferase D2M30_00930 ENOG4105D1F ATP-binding protein D2M30_00945 ENOG4108NMV polysaccharide deacetylase D2M30_01010 ENOG4108JPW Aminotransferase D2M30_01020 ENOG4105CPQ Dehydrogenase D2M30_01025 ENOG4105CHH sulfate transporter D2M30_01035 ENOG4108SA1 esterase D2M30_01055 ENOG410874W AraC family transcriptional regulator D2M30_01060 ENOG4105EHZ conserved protein UCP016719 D2M30_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein D2M30_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D2M30_01090 ENOG4105EWC Purine nucleoside phosphorylase D2M30_01120 ENOG4105EMN RNA polymerase sigma factor D2M30_01130 ENOG4105C8B TIGR00159 family D2M30_01135 ENOG4107U5W ybbr family D2M30_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D2M30_01165 ENOG4106K80 D2M30_01175 ENOG41067MG lrgb family D2M30_01185 ENOG41061AU MarR family Transcriptional regulator D2M30_01200 ENOG4105BZU Histidine kinase D2M30_01205 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_01210 ENOG4105CJ1 ABC, transporter D2M30_01220 ENOG41090VJ ABC-2 type transporter D2M30_01235 ENOG4106DDH Sporulation-specific SASP protein D2M30_01250 ENOG4107QTZ amino acid D2M30_01265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase D2M30_01270 ENOG4105CXY transporter D2M30_01300 ENOG410631K Membrane D2M30_01305 ENOG4106AXJ AraC family transcriptional regulator D2M30_01325 ENOG4107SCQ Iron-containing alcohol dehydrogenase D2M30_01330 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D2M30_01335 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase D2M30_01340 ENOG4107ZTW SNARE associated Golgi D2M30_01355 ENOG4105C72 UPF0176 protein D2M30_01365 ENOG4105CM2 brancheD-chain amino acid aminotransferase D2M30_01370 ENOG4108IQI permease D2M30_01375 ENOG4108J5H Homocysteine s-methyltransferase D2M30_01385 ENOG4105CSV Glutaminase D2M30_01410 ENOG41076HS cation diffusion facilitator family transporter D2M30_01420 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase D2M30_01425 ENOG4108VGI doxx family D2M30_01430 ENOG4105XXY Thioredoxin D2M30_01455 ENOG4105DGI Alkaline phosphatase D2M30_01460 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D2M30_01465 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D2M30_01470 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D2M30_01475 ENOG4107EPV Aminotransferase class V D2M30_01480 ENOG4105C0R drug resistance transporter emrb qaca subfamily D2M30_01485 ENOG4105J7D transcriptional regulator D2M30_01490 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold D2M30_01495 ENOG41060AI SEC-C motif D2M30_01500 ENOG4107SET aldo keto reductase D2M30_01530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D2M30_01540 ENOG4105DSE periplasmic solute binding protein D2M30_01545 ENOG4105DIK (ABC) transporter D2M30_01555 ENOG4105DEN Luciferase family D2M30_01560 ENOG4108N0M stress protein D2M30_01565 ENOG4106FN3 tellurium resistance protein D2M30_01570 ENOG4106FN3 tellurium resistance protein D2M30_01575 ENOG4107TS3 membrane protein, TerC D2M30_01580 ENOG4108TTB tellurium resistance protein D2M30_01590 ENOG41079KZ Major Facilitator Superfamily D2M30_01595 ENOG4108IJ7 Glycine betaine D2M30_01600 ENOG4107SQ8 Glycine betaine D2M30_01630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D2M30_01660 ENOG4105EIG urea carboxylase-associated protein 1 D2M30_01665 ENOG4107RA1 nh(3)-dependent nad( ) synthetase D2M30_01670 ENOG4108WBH protein TIM barrel D2M30_01675 ENOG4105DJB Major Facilitator Superfamily D2M30_01680 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D2M30_01685 ENOG4105I82 acetyl xylan esterase D2M30_01690 ENOG410756H nucleotidyltransferase D2M30_01700 ENOG4105C26 Dehydrogenase D2M30_01705 ENOG4105CK7 Sodium proline symporter D2M30_01710 ENOG4107YHD transcriptional regulator D2M30_01715 ENOG4105CAY ferredoxin--nadp reductase D2M30_01720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D2M30_01725 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit D2M30_01730 ENOG4108IFG nitrite reductase, (NAD(P)H) D2M30_01740 ENOG4105CKI cobalamin synthesis protein D2M30_01745 ENOG4105E2A Dehydrogenase D2M30_01750 ENOG4105HHM rdd domain containing protein D2M30_01760 ENOG4105CS2 ec 3.2.1.21 D2M30_01780 ENOG41080HJ 6-phospho 3-hexuloisomerase D2M30_01785 ENOG4108VA3 3-hexulose-6-phosphate synthase D2M30_01790 ENOG4105KVH Transcriptional regulator D2M30_01800 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_01820 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D2M30_01835 ENOG4105CDA abc transporter atp-binding protein D2M30_01840 ENOG4105DRP amino acid AbC transporter D2M30_01850 ENOG4106P55 Transcriptional regulator D2M30_01855 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D2M30_01860 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D2M30_01865 ENOG41069ZX D2M30_01870 ENOG41069ZX D2M30_01875 ENOG4105DUX Transporter D2M30_01890 ENOG4105E1K spore germination protein D2M30_01905 ENOG4105CPU Monooxygenase D2M30_01910 ENOG4108XSB acetyltransferase, (GNAT) family D2M30_01915 ENOG4105EAB amino acid AbC transporter D2M30_01920 ENOG4108HW4 amino acid AbC transporter D2M30_01930 ENOG4105CH2 amidohydrolase D2M30_01935 ENOG4108PGP mmge prpd family protein D2M30_01945 ENOG4107WD8 ABC transporter, permease D2M30_01950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D2M30_01955 ENOG4105BZU Histidine kinase D2M30_01975 ENOG4105CFH Aspartokinase D2M30_01980 ENOG4105DHS permease protein D2M30_01985 ENOG4105CM4 permease protein D2M30_01990 ENOG4108IPW abc transporter atp-binding protein D2M30_02005 ENOG4105R8C Transcriptional regulator D2M30_02010 ENOG4108DBC nitroreductase D2M30_02015 ENOG41067V3 Antibiotic biosynthesis monooxygenase D2M30_02020 ENOG4105YVS arsR family transcriptional regulator D2M30_02030 ENOG4108JPW Aminotransferase D2M30_02035 ENOG4105C26 Dehydrogenase D2M30_02045 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D2M30_02050 ENOG4105KTB nuclear export factor GLE1 D2M30_02055 ENOG4108T5E Copper resistance protein D2M30_02060 ENOG4108ZYE Transcriptional regulator D2M30_02080 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase D2M30_02100 ENOG4105E7W lamb ycsf family protein D2M30_02105 ENOG4105C5A transporter D2M30_02110 ENOG4105CFM UPF0317 protein D2M30_02115 ENOG4105P4J Allophanate hydrolase, subunit 1 D2M30_02125 ENOG4107258 Transcriptional regulator D2M30_02130 ENOG4105XJB lipolytic protein G-D-S-L family D2M30_02140 ENOG41061CK Antibiotic biosynthesis monooxygenase D2M30_02145 ENOG4107RVG penicillin-binding protein D2M30_02150 ENOG4107QM2 Aldo Keto reductase D2M30_02155 ENOG4105ETD TRANSCRIPTIONal D2M30_02165 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D2M30_02180 ENOG410606W general stress protein D2M30_02190 ENOG4105VCH membrane D2M30_02200 ENOG4105C9U ATP-dependent DNA helicase RecQ D2M30_02215 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) D2M30_02220 ENOG4107R8N Glycosyl transferase, family 2 D2M30_02230 ENOG4105C0X amino acid D2M30_02255 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) D2M30_02265 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) D2M30_02270 ENOG4105RXJ D2M30_02275 ENOG4105KPY Small multidrug resistance protein D2M30_02280 ENOG4105EU9 D2M30_02285 ENOG4105QVS general stress protein D2M30_02290 ENOG41082W1 Cupin 2, conserved barrel domain protein D2M30_02305 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D2M30_02310 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D2M30_02315 ENOG4108MRH transcriptional regulatory protein D2M30_02320 ENOG4107QJT sodium dicarboxylate symporter D2M30_02325 ENOG4106F5Q Membrane D2M30_02330 ENOG4105CJ1 ABC, transporter D2M30_02345 ENOG4105FDT acyl-CoA dehydrogenase D2M30_02370 ENOG4105SZ6 Thioredoxin D2M30_02375 ENOG4105CPF Cell wall formation (By similarity) D2M30_02380 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) D2M30_02385 ENOG4105C1J atp-dependent rna helicase D2M30_02390 ENOG410905X membrane-flanked domain protein D2M30_02395 ENOG4105CKV Membrane D2M30_02405 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D2M30_02415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D2M30_02425 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) D2M30_02430 ENOG4107MMM Anti-sigma-factor antagonist D2M30_02435 ENOG4105FUA antagonist D2M30_02440 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase D2M30_02445 ENOG4107SGM protein serine threonine phosphatase D2M30_02450 ENOG4105WN5 stage II sporulation protein D2M30_02455 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) D2M30_02465 ENOG41064BQ Phosphatase D2M30_02480 ENOG410906U SprT-like D2M30_02525 ENOG4105D3P Mannan endo-1,4-beta-mannosidase D2M30_02530 ENOG4108U05 Transcriptional regulator D2M30_02535 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 D2M30_02590 ENOG4105K56 Transcriptional regulator D2M30_02595 ENOG410645S MarR family Transcriptional regulator D2M30_02600 ENOG4105DCM major facilitator superfamily D2M30_02605 ENOG4105D3P Mannan endo-1,4-beta-mannosidase D2M30_02625 ENOG410847I Transcriptional regulator, BadM Rrf2 family D2M30_02640 ENOG4105VEQ Cold shock protein D2M30_02665 ENOG4105DXI Major Facilitator superfamily D2M30_02670 ENOG4105IRW patatin-like phospholipase family protein D2M30_02680 ENOG4105DNP FAD linked oxidase domain protein D2M30_02690 ENOG4105PGM cation diffusion facilitator family transporter D2M30_02700 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein D2M30_02710 ENOG4108U7W acetyltransferase D2M30_02715 ENOG41086D8 Transcriptional regulator D2M30_02735 ENOG4105DQ4 alcohol dehydrogenase D2M30_02740 ENOG4105VUF Transcriptional regulator D2M30_02750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D2M30_02765 ENOG4105EQ0 Major Facilitator superfamily D2M30_02770 ENOG4108JGH Tetr family transcriptional regulator D2M30_02775 ENOG4105T38 integral membrane protein D2M30_02780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D2M30_02795 ENOG4105E2A Dehydrogenase D2M30_02800 ENOG4105PGS Spore coat protein D2M30_02825 ENOG4108JYZ YitT family D2M30_02835 ENOG4105C2C drug resistance transporter, Bcr CflA D2M30_02840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D2M30_02860 ENOG41090E6 transcriptional regulator MERR family D2M30_02875 ENOG4105EBM Alpha Beta Hydrolase Fold protein D2M30_02880 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D2M30_02885 ENOG4105DRR Transcriptional regulator, GntR family D2M30_02900 ENOG4105FQP Beta-lactamase D2M30_02905 ENOG41090UD (LipO)protein D2M30_02910 ENOG4108SUT Major Facilitator Superfamily D2M30_02915 ENOG4108TZY GntR Family Transcriptional Regulator D2M30_02920 ENOG4105JXH GntR family transcriptional regulator D2M30_02925 ENOG4105DJ2 Major Facilitator Superfamily D2M30_02945 ENOG4107QTZ amino acid D2M30_02965 ENOG4107QNK )-transporter D2M30_03005 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D2M30_03010 ENOG4105K8N protein family UPF0079, ATPase D2M30_03015 ENOG41072GX Peptidase M22 Glycoprotease D2M30_03020 ENOG410801F ribosomal-protein-alanine acetyltransferase D2M30_03025 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D2M30_03030 ENOG4105C5H ABC transporter D2M30_03035 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D2M30_03040 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) D2M30_03045 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D2M30_03050 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D2M30_03060 ENOG4108TYN CAAX amino terminal protease family protein D2M30_03065 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D2M30_03070 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D2M30_03080 ENOG4106BHF D2M30_03105 ENOG4105DZR Type I site-specific deoxyribonuclease D2M30_03110 ENOG4105PGZ NB-ARC domain D2M30_03115 ENOG4105CPQ Dehydrogenase D2M30_03120 ENOG4105CT4 transporter D2M30_03135 ENOG41087YS Phage shock protein A D2M30_03140 ENOG4105DQX Zinc finger domain D2M30_03145 ENOG4108WV1 Pfam:DUF477 D2M30_03155 ENOG4105EXC Acyl-transferase D2M30_03160 ENOG4108P49 AntiSigma factor D2M30_03165 ENOG4105JVQ RNA Polymerase D2M30_03190 ENOG4107STQ Multicopper oxidase D2M30_03195 ENOG4105C85 amino acid D2M30_03210 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D2M30_03225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D2M30_03240 ENOG4105C7N Xanthine uracil vitamin C permease D2M30_03265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D2M30_03270 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D2M30_03275 ENOG4105C83 adenylosuccinate lyase D2M30_03280 ENOG4105C8V SAICAR synthetase D2M30_03285 ENOG4105VR9 phosphoribosylformylglycinamidine synthase D2M30_03290 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I D2M30_03295 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii D2M30_03305 ENOG4105CXB phosphoribosylaminoimidazole synthetase D2M30_03310 ENOG4108V3E phosphoribosylglycinamide formyltransferase D2M30_03315 ENOG4105DC1 bifunctional purine biosynthesis protein purh D2M30_03320 ENOG4105C12 Phosphoribosylglycinamide synthetase D2M30_03330 ENOG4105DVH amino acid D2M30_03345 ENOG4108R5T secreted protein D2M30_03350 ENOG4105KGF protein, YerC YecD D2M30_03355 ENOG4105CBC glutamate synthase D2M30_03365 ENOG4105C4R Atp-dependent dna helicase D2M30_03370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D2M30_03380 ENOG4105CRN Aminoglycoside phosphotransferase D2M30_03385 ENOG4105KT7 mgtC SapB transporter D2M30_03390 ENOG4105CK7 Sodium proline symporter D2M30_03395 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D2M30_03400 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D2M30_03405 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D2M30_03410 ENOG4108IG5 Transcriptional regulator D2M30_03420 ENOG4105CBD Diacylglycerol kinase D2M30_03425 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D2M30_03430 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_03450 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D2M30_03460 ENOG4105CHR reductase D2M30_03465 ENOG4105CJ1 ABC, transporter D2M30_03515 ENOG4106BHF D2M30_03520 ENOG4105CDY transcriptional regulatory protein D2M30_03530 ENOG41075D4 Aminoglycoside 6-adenylyltransferase D2M30_03545 ENOG4105WEF catalase D2M30_03550 ENOG4105M18 -acetyltransferase D2M30_03560 ENOG4105H67 Protein of unknown function (DUF421) D2M30_03565 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) D2M30_03570 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily D2M30_03590 ENOG4106I4J membrane D2M30_03600 ENOG41082F9 transcriptional regulator D2M30_03605 ENOG41061H0 Monooxygenase D2M30_03610 ENOG4108R1P D2M30_03615 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D2M30_03625 ENOG4105E0M Sulfatase D2M30_03630 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase D2M30_03640 ENOG41090R9 glycosyltransferase D2M30_03645 ENOG4107R51 Glycosyl transferase, family 2 D2M30_03650 ENOG41090R9 glycosyltransferase D2M30_03655 ENOG4105EU0 Major facilitator Superfamily D2M30_03660 ENOG4105CUB amino acid D2M30_03665 ENOG4105C26 Dehydrogenase D2M30_03670 ENOG4105FKZ Methyl-accepting chemotaxis D2M30_03675 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D2M30_03680 ENOG4107TVC Glycosyl transferase, family 2 D2M30_03685 ENOG4105C5H ABC transporter D2M30_03690 ENOG4107SWG transcriptional regulator MERR family D2M30_03695 ENOG4105DXB Major Facilitator superfamily D2M30_03700 ENOG4105C5H ABC transporter D2M30_03705 ENOG4105FDU atp-dependent rna helicase D2M30_03710 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein D2M30_03725 ENOG4108J20 pectate lyase D2M30_03730 ENOG4107QPK )-transporter D2M30_03760 ENOG4108MRH transcriptional regulatory protein D2M30_03785 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) D2M30_03790 ENOG4108RPX mosc domain containing protein D2M30_03805 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) D2M30_03845 ENOG4105C5Y PTS System D2M30_03850 ENOG4105CG3 alpha amylase, catalytic region D2M30_03855 ENOG4107414 GntR family transcriptional regulator D2M30_03860 ENOG4108RCM Nitroreductase D2M30_03875 ENOG4105CGH 5'-nucleotidase D2M30_03880 ENOG4107RKG DJ-1/PfpI family D2M30_03885 ENOG4105ETE Transcriptional regulator (LacI family D2M30_03890 ENOG4105E2X shikimate dehydrogenase D2M30_03895 ENOG4105FF2 Type I DHQase D2M30_03910 ENOG4105KJF protein tyrosine phosphatase D2M30_03920 ENOG4107U9T Pfam:Ribonuclease_BN D2M30_03925 ENOG4108ISG Major Facilitator D2M30_03930 ENOG4105UPD Calcium Proton D2M30_03940 ENOG4105D8X mechanosensitive ion channel D2M30_03960 ENOG4106KE4 Dehydrogenase D2M30_03970 ENOG4105D7N magnesium and cobalt transport protein CorA D2M30_03980 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D2M30_03995 ENOG4105BZ1 (ABC) transporter D2M30_04000 ENOG4105CJA serine threonine protein kinase D2M30_04020 ENOG4107RUY (E1 component), alpha subunit D2M30_04030 ENOG4107QKR Dehydrogenase D2M30_04040 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D2M30_04050 ENOG4105F8D glycoside hydrolase family 4 D2M30_04055 ENOG4108Q3X Transcriptional regulator D2M30_04060 ENOG4105CI1 PTS System D2M30_04070 ENOG4105BZ1 (ABC) transporter D2M30_04075 ENOG4105BZ1 (ABC) transporter D2M30_04085 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase D2M30_04090 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D2M30_04095 ENOG4105U3E Transcriptional regulator D2M30_04100 ENOG4105DYS nad(p)h dehydrogenase (quinone) D2M30_04105 ENOG4105H93 Acyltransferase family D2M30_04115 ENOG4108YYS metal-dependent hydrolase (By similarity) D2M30_04120 ENOG4105C0R drug resistance transporter emrb qaca subfamily D2M30_04125 ENOG410834F Transcriptional regulator D2M30_04135 ENOG4105JAB phenazine biosynthesis protein, phzf family D2M30_04140 ENOG4107Y03 Nitroreductase D2M30_04155 ENOG4105ECP epimerase D2M30_04160 ENOG410902V Modulates RecA activity (By similarity) D2M30_04170 ENOG4105F27 Major Facilitator D2M30_04180 ENOG4108TCS Glutamyl endopeptidase D2M30_04200 ENOG4106AKJ D2M30_04205 ENOG4105D74 hydrolase D2M30_04210 ENOG4105CKK Glycosyl transferase, family 2 D2M30_04215 ENOG4105EJV Membrane D2M30_04220 ENOG41067AE Membrane-bound metal-dependent hydrolase D2M30_04225 ENOG4105CEN a g-specific adenine glycosylase D2M30_04230 ENOG4106BXE D2M30_04235 ENOG4105CAN Short-chain dehydrogenase reductase Sdr D2M30_04255 ENOG4105BZ1 (ABC) transporter D2M30_04260 ENOG4107NBY Membrane D2M30_04265 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D2M30_04270 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D2M30_04275 ENOG4105G5W regulator Fur family D2M30_04280 ENOG4105TUA UPF0295 protein D2M30_04385 ENOG4107S6Z Na H antiporter D2M30_04390 ENOG4105EC3 peptidase S51, dipeptidase E D2M30_04395 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D2M30_04400 ENOG4105DNP FAD linked oxidase domain protein D2M30_04410 ENOG4105DEF Extracellular solute-binding protein, family 5 D2M30_04420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D2M30_04425 ENOG4105C3U ABC transporter D2M30_04430 ENOG4108JQ7 (ABC) transporter D2M30_04445 ENOG4105E2Y ABC, transporter D2M30_04450 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein D2M30_04455 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D2M30_04465 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D2M30_04470 ENOG4107D63 D2M30_04475 ENOG4105VZ8 Transcriptional regulator D2M30_04490 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D2M30_04500 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D2M30_04525 ENOG4105CYN Serine protein kinase D2M30_04535 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D2M30_04540 ENOG4105CW7 secretion protein, HlyD family D2M30_04545 ENOG4105C0R drug resistance transporter emrb qaca subfamily D2M30_04550 ENOG4105CS1 NAD(P)H quinone oxidoreductase D2M30_04565 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family D2M30_04570 ENOG4105CZV ABC transporter D2M30_04575 ENOG4105CJ1 ABC, transporter D2M30_04580 ENOG4108TU7 Inherit from COG: (ABC) transporter D2M30_04585 ENOG4105VEQ Cold shock protein D2M30_04595 ENOG4105BZU Histidine kinase D2M30_04605 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D2M30_04640 ENOG4108YBP pseudouridine synthase D2M30_04650 ENOG41080XP Cbs domain D2M30_04655 ENOG4107YBY Hydrolase D2M30_04660 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D2M30_04665 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D2M30_04670 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator D2M30_04680 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D2M30_04685 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D2M30_04695 ENOG4105BZU Histidine kinase D2M30_04700 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_04735 ENOG4105ED1 spovr family D2M30_04740 ENOG4105G6Z alkaline phosphatase D2M30_04755 ENOG4105BZN citrate synthase D2M30_04760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D2M30_04765 ENOG4105CUB amino acid D2M30_04770 ENOG4105C8J )-transporter D2M30_04780 ENOG4105J37 D2M30_04785 ENOG4108AEY RNA polymerase sigma factor D2M30_04790 ENOG4105F6E Acyl-transferase D2M30_04795 ENOG4105C37 (CBS) domain D2M30_04805 ENOG4105CHM Aminotransferase D2M30_04810 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase D2M30_04815 ENOG4105C37 (CBS) domain D2M30_04825 ENOG4105WMR Protein CrcB homolog D2M30_04830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D2M30_04840 ENOG4105D64 Mechanosensitive ion channel D2M30_04845 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D2M30_04850 ENOG4107VMI polysaccharide deacetylase D2M30_04855 ENOG4105F0I Aminotransferase D2M30_04860 ENOG4105W1N transcriptional regulator D2M30_04865 ENOG4105IIP Membrane D2M30_04875 ENOG4105BZ1 (ABC) transporter D2M30_04880 ENOG4105BZ1 (ABC) transporter D2M30_04905 ENOG410839P D2M30_04915 ENOG4106MP8 UPF0754 membrane protein D2M30_04920 ENOG4105WZB UPF0342 protein D2M30_04930 ENOG4105D4P Coproporphyrinogen iii oxidase D2M30_04940 ENOG4107S91 Sodium hydrogen exchanger D2M30_04945 ENOG4105NCW Trka-c domain protein D2M30_04955 ENOG4105CGU Enoyl-CoA hydratase D2M30_04965 ENOG4108IUX (ABC) transporter D2M30_04970 ENOG4105RHA ABC transporter, permease D2M30_04975 ENOG4107VRP DNA repair exonuclease D2M30_04980 ENOG4106D4I domain protein D2M30_04985 ENOG4105EQI Metal Dependent Phosphohydrolase D2M30_04995 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) D2M30_05045 ENOG4105NBU tryptophan transport protein D2M30_05050 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D2M30_05055 ENOG4105K59 histidine triad (HIT) protein D2M30_05085 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation D2M30_05090 ENOG4105BZ4 penicillin-binding protein D2M30_05095 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D2M30_05100 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D2M30_05105 ENOG4105C1Q protoporphyrinogen oxidase D2M30_05115 ENOG4105ECB domain protein D2M30_05135 ENOG4105DER m42 family D2M30_05145 ENOG4106AXD D2M30_05150 ENOG4108RQ5 Beta-lactamase domain-containing protein D2M30_05155 ENOG4105DF9 Lipoate-protein, ligase D2M30_05165 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_05175 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 D2M30_05190 ENOG4108HUF Transporter D2M30_05195 ENOG4107TB6 phosphoglycerate mutase D2M30_05205 ENOG4107F3J Amp-dependent synthetase and ligase D2M30_05210 ENOG4107ZYJ bioY protein D2M30_05215 ENOG4106YBV Methyl-accepting chemotaxis D2M30_05235 ENOG4105XVF Competence transcription factor D2M30_05240 ENOG4108ZMX Domain of unknown function (DU1801) D2M30_05255 ENOG4105X3H Excalibur domain protein D2M30_05260 ENOG4105K8R UPF0145 protein D2M30_05265 ENOG4105E1V na solute symporter D2M30_05270 ENOG4106CAD Protein of unknown function (DUF3311) D2M30_05275 ENOG41060YP D2M30_05290 ENOG4107SCK Monooxygenase D2M30_05295 ENOG4108INS Transcriptional regulator D2M30_05300 ENOG4108KK1 membrane protein AbrB duplication D2M30_05310 ENOG4108IG5 Transcriptional regulator D2M30_05320 ENOG4108QY0 Membrane D2M30_05325 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination D2M30_05330 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D2M30_05340 ENOG4105EYH Exonuclease D2M30_05385 ENOG4105ERH Fumarylacetoacetate hydrolase D2M30_05395 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D2M30_05405 ENOG4105CAQ asparagine synthetase D2M30_05415 ENOG4105UQX Mate efflux family protein D2M30_05420 ENOG4106HBX Transcriptional Regulator AraC Family D2M30_05425 ENOG4105ETE Transcriptional regulator (LacI family D2M30_05430 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D2M30_05435 ENOG4105SF0 DinB family D2M30_05440 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D2M30_05445 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D2M30_05450 ENOG4105MYW Pentapeptide repeat protein D2M30_05455 ENOG4105MA6 gCN5-related N-acetyltransferase D2M30_05465 ENOG4108VPT UPF0234 protein D2M30_05470 ENOG4105QNR S1 RNA binding domain protein D2M30_05475 ENOG4105DIH basic membrane D2M30_05480 ENOG4105C8Q Methyl-accepting chemotaxis D2M30_05485 ENOG4107E6A Cytochrome p-450 D2M30_05495 ENOG4105EPR degv family D2M30_05500 ENOG4107AYK membrAne D2M30_05510 ENOG41073B9 D2M30_05515 ENOG4108KP7 hydrolase D2M30_05520 ENOG4108MXZ Esterase D2M30_05525 ENOG4105VG1 fes assembly suf system protein D2M30_05530 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) D2M30_05535 ENOG4105IQ5 FAD linked oxidase domain protein D2M30_05545 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D2M30_05555 ENOG4105CAS nag kinase D2M30_05560 ENOG4105C8Y Acetylornithine aminotransferase D2M30_05565 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D2M30_05575 ENOG4105DBV ornithine carbamoyltransferase D2M30_05605 ENOG4107RMD Basic membrane lipoprotein D2M30_05620 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D2M30_05625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D2M30_05635 ENOG4105C3U ABC transporter D2M30_05640 ENOG4108JQ7 (ABC) transporter D2M30_05655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D2M30_05665 ENOG4105C31 Tryptophanyl-tRNA synthetase D2M30_05675 ENOG4108J59 Extracellular solute-binding protein, family 5 D2M30_05680 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D2M30_05685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D2M30_05695 ENOG4108JQ7 (ABC) transporter D2M30_05710 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) D2M30_05715 ENOG4108ZCF integral membrane protein D2M30_05720 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis D2M30_05730 ENOG4105DPN Oligoendopeptidase f D2M30_05735 ENOG4105T58 Dithiol-disulfide isomerase D2M30_05740 ENOG4108Z18 K06886 hemoglobin D2M30_05745 ENOG4105E4C Lytic transglycosylase catalytic D2M30_05750 ENOG4105MIX Adenylate cyclase D2M30_05765 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D2M30_05770 ENOG4105EMS pseudouridine synthase D2M30_05775 ENOG4107S1Q Phosphatase D2M30_05785 ENOG4105ETU transcriptional activator (TenA D2M30_05790 ENOG4108VEU Thiamine monophosphate synthase D2M30_05810 ENOG4105D06 uba thif-type nad fad binding protein D2M30_05815 ENOG4105DWF phosphomethylpyrimidine kinase D2M30_05820 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D2M30_05825 ENOG4107A88 D2M30_05875 ENOG4105ENA helicase D2M30_05895 ENOG4105CJ1 ABC, transporter D2M30_05910 ENOG4108ZMI UPF0477 protein D2M30_05920 ENOG4105C28 cystathionine D2M30_05925 ENOG4105C28 cystathionine D2M30_05945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D2M30_06180 ENOG4105CK1 PTS System D2M30_06185 ENOG4105VCP PTS System D2M30_06195 ENOG4105E98 transcriptional regulator DeoR family D2M30_06215 ENOG4105KT7 mgtC SapB transporter D2M30_06235 ENOG4108IEG Formate dehydrogenase Alpha subunit D2M30_06245 ENOG4106A3M Cytochrome p-450 D2M30_06250 ENOG41087PP glycosyltransferase MGT family D2M30_06260 ENOG4105EXQ uroporphyrinogen iii synthase hem4 D2M30_06265 ENOG4105C4B ABC transporter, permease D2M30_06270 ENOG4108IXI (ABC) transporter D2M30_06280 ENOG4105Q95 Cupin 2, conserved barrel domain protein D2M30_06295 ENOG4105D2H Uronic isomerase D2M30_06300 ENOG4107KJX Transcriptional regulator D2M30_06315 ENOG4105BZU Histidine kinase D2M30_06330 ENOG4107TSN permease D2M30_06345 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase D2M30_06350 ENOG4105KWG Pfam:DUF1696 D2M30_06355 ENOG4105K7W phage-related replication protein D2M30_06360 ENOG410635T phage-like element pbsx protein D2M30_06400 ENOG4108TFU terminase (Small subunit) D2M30_06405 ENOG4105IG6 Phage terminase, large subunit D2M30_06410 ENOG4108MDF Phage Portal Protein D2M30_06435 ENOG41060SN D2M30_06450 ENOG4105PQS phage protein D2M30_06455 ENOG4105FR7 XkdM protein, phage-like element PBSX D2M30_06460 ENOG4105MTC XkdN-like protein D2M30_06470 ENOG4108FKH Transglycosylase SLT domain D2M30_06470 ENOG4108FKH Transglycosylase SLT domain D2M30_06475 ENOG4108WZM domain protein D2M30_06480 ENOG4105X7F D2M30_06490 ENOG4105MFU Protein of unknown function (DUF2634) D2M30_06495 ENOG41066EA baseplate J family protein D2M30_06500 ENOG410906S phage-like element pbsx protein xkdt D2M30_06510 ENOG41068G1 D2M30_06540 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase D2M30_06555 ENOG4105CJ3 phosphate transporter D2M30_06560 ENOG4107GRR phosphate transport regulator D2M30_06565 ENOG4107R7I amino acid D2M30_06575 ENOG4105EDW glycosyl transferase, family 39 D2M30_06580 ENOG4105CKK Glycosyl transferase, family 2 D2M30_06585 ENOG4105C0H protease D2M30_06595 ENOG4108ME1 Peptidase M55 D-aminopeptidase D2M30_06600 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D2M30_06605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D2M30_06610 ENOG4105C3U ABC transporter D2M30_06620 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D2M30_06625 ENOG4105DTQ mandelate racemase muconate lactonizing D2M30_06630 ENOG4107SN7 NLP P60 protein D2M30_06635 ENOG4108JQ7 (ABC) transporter D2M30_06640 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D2M30_06645 ENOG4107TUM Amidinotransferase D2M30_06650 ENOG4108S4H thioesterase Superfamily protein D2M30_06655 ENOG4108428 Inherit from COG: -acetyltransferase D2M30_06665 ENOG41080TC multidrug resistance protein D2M30_06670 ENOG4105CIY formyltetrahydrofolate deformylase D2M30_06675 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D2M30_06690 ENOG4105K56 Transcriptional regulator D2M30_06695 ENOG4108ZHJ Organic hydroperoxide resistance protein D2M30_06710 ENOG4107TVC Glycosyl transferase, family 2 D2M30_06725 ENOG4105D8G Major Facilitator superfamily D2M30_06730 ENOG4108Y4K DNA-binding transcriptional activator D2M30_06735 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D2M30_06740 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D2M30_06750 ENOG4108W7F transporter, permease D2M30_06755 ENOG4108JJB ABC transporter D2M30_06760 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein D2M30_06765 ENOG4105VRS hydrolase family 18 D2M30_06780 ENOG4105CJW magnesium transporter D2M30_06785 ENOG4105V75 Transcriptional regulator D2M30_06810 ENOG4105DQE DNA ligase D2M30_06815 ENOG4105FDF Could be involved in DNA repair (By similarity) D2M30_06820 ENOG4105BZU Histidine kinase D2M30_06825 ENOG4107T5V SNARE associated Golgi D2M30_06830 ENOG4107TS3 membrane protein, TerC D2M30_06835 ENOG4108WZW RNA polymerase sigma D2M30_06845 ENOG410681C small acid-soluble spore protein D2M30_06855 ENOG4105D0M Protease HtpX homolog D2M30_06865 ENOG410900G Protein of unknown function (DUF421) D2M30_06875 ENOG4108TGC Acyltransferase D2M30_06880 ENOG4105BZU Histidine kinase D2M30_06885 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D2M30_06890 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) D2M30_06900 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D2M30_06910 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate D2M30_06915 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) D2M30_06920 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) D2M30_06925 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) D2M30_06940 ENOG4105BZU Histidine kinase D2M30_06945 ENOG41090MY MarR family Transcriptional regulator D2M30_06950 ENOG4105ER2 Ompa motb domain protein D2M30_06955 ENOG4105E14 MotA TolQ exbB proton channel D2M30_06970 ENOG4108K88 Membrane D2M30_06980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D2M30_06985 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase D2M30_06990 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D2M30_06995 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D2M30_07015 ENOG4105F0V Cell wall hydrolase D2M30_07030 ENOG4105C59 p-type ATPase D2M30_07035 ENOG4105DC7 peptidase M24 D2M30_07045 ENOG4105CID antiterminator D2M30_07055 ENOG4105KRI phosphocarrier protein (HPr D2M30_07060 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D2M30_07070 ENOG4105F6S Spore photoproduct lyase D2M30_07075 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer D2M30_07080 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D2M30_07085 ENOG4105K4I Scp-like extracellular D2M30_07095 ENOG4105BZU Histidine kinase D2M30_07100 ENOG4105CHM Aminotransferase D2M30_07110 ENOG4107R88 Chemotaxis protein (CheV) D2M30_07115 ENOG4105UIN D2M30_07125 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein D2M30_07135 ENOG4105K6S Short-chain dehydrogenase reductase Sdr D2M30_07145 ENOG4105EPM Diguanylate phosphodiesterase D2M30_07155 ENOG4107IN1 Protein of unknown function (DUF1797) D2M30_07160 ENOG4108XRC Protein of unknown function (DUF458) D2M30_07190 ENOG4105NQC Flavodoxin D2M30_07210 ENOG4105D8X mechanosensitive ion channel D2M30_07220 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D2M30_07235 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D2M30_07240 ENOG4105D06 uba thif-type nad fad binding protein D2M30_07245 ENOG4105CVM Molybdenum cofactor synthesis domain protein D2M30_07250 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein D2M30_07255 ENOG4108ZAF Molybdopterin D2M30_07260 ENOG41067WU Molybdopterin converting factor (Subunit 1) D2M30_07270 ENOG4107X8C Efflux transporter RND family MFP subunit D2M30_07275 ENOG4105C19 ABC transporter D2M30_07280 ENOG4107RBB ABC transporter, permease D2M30_07285 ENOG4105E98 transcriptional regulator DeoR family D2M30_07290 ENOG4105DE4 1-phosphofructokinase D2M30_07295 ENOG4105DM4 PTS System D2M30_07310 ENOG4105C5H ABC transporter D2M30_07315 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D2M30_07345 ENOG4105BZU Histidine kinase D2M30_07355 ENOG4107ZYR domain protein D2M30_07360 ENOG4105CPN adenine deaminase D2M30_07365 ENOG4105CN5 Metallo-Beta-Lactamase D2M30_07370 ENOG4106148 UPF0356 protein D2M30_07380 ENOG4108X4Q Hydrolase D2M30_07385 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D2M30_07405 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D2M30_07410 ENOG4105C0W non-ribosomal peptide synthetase D2M30_07415 ENOG4107SQU synthase D2M30_07425 ENOG4105C0W non-ribosomal peptide synthetase D2M30_07430 ENOG4107SQU synthase D2M30_07435 ENOG4107SQU synthase D2M30_07440 ENOG4105C0W non-ribosomal peptide synthetase D2M30_07445 ENOG4105FQP Beta-lactamase D2M30_07455 ENOG4105CPP Dehydrogenase, E1 component D2M30_07460 ENOG4105C7S Dehydrogenase D2M30_07465 ENOG4107QN2 dihydrolipoyl dehydrogenase D2M30_07490 ENOG4105WBI UPF0223 protein D2M30_07545 ENOG4105CI3 gtp-binding protein typa D2M30_07550 ENOG4105QA2 D2M30_07565 ENOG4108IAB Phoh family D2M30_07575 ENOG4105CSV Glutaminase D2M30_07585 ENOG4105CNI cell division protein FtsW D2M30_07590 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) D2M30_07600 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D2M30_07610 ENOG4105BZ9 Cytochrome C oxidase, subunit I D2M30_07615 ENOG4105CCU oxidase (Subunit III) D2M30_07620 ENOG41064X9 cytochrome C oxidase subunit IV D2M30_07635 ENOG41080XQ Signal transduction protein with cbs domains D2M30_07640 ENOG4106UY4 Inherit from COG: Scp-like extracellular D2M30_07665 ENOG4106H78 methyltransferase D2M30_07670 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D2M30_07675 ENOG4105H20 Sporulation integral membrane protein YlbJ D2M30_07680 ENOG4105D78 K07001 NTE family protein D2M30_07685 ENOG41063PX domain protein D2M30_07690 ENOG4105CDE UPF0348 protein D2M30_07695 ENOG4105KNH Nucleic acid-binding protein D2M30_07700 ENOG41067VY 50S ribosomal protein L32 D2M30_07725 ENOG4108V6E Cell division protein mraZ D2M30_07730 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D2M30_07740 ENOG4105CJN penicillin-binding protein D2M30_07745 ENOG4105CJN penicillin-binding protein D2M30_07750 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D2M30_07755 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D2M30_07760 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D2M30_07765 ENOG4105CNI cell division protein FtsW D2M30_07770 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D2M30_07775 ENOG4105D4A Cell wall formation (By similarity) D2M30_07780 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) D2M30_07785 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D2M30_07790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D2M30_07800 ENOG4105FFI sigma-e processing peptidase spoiiga D2M30_07805 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_07815 ENOG4105DKW ABC transporter D2M30_07825 ENOG4105WR5 sporulation protein, YlmC YmxH family D2M30_07830 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D2M30_07835 ENOG4105DFA alanine racemase domain protein D2M30_07840 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) D2M30_07845 ENOG41067XK integral membrane protein D2M30_07850 ENOG4105DBK s4 domain protein D2M30_07865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D2M30_07875 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D2M30_07880 ENOG4105C34 Pseudouridine synthase D2M30_07885 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) D2M30_07895 ENOG4105CXT aspartate transcarbamylase D2M30_07905 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D2M30_07910 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D2M30_07915 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) D2M30_07920 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) D2M30_07925 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D2M30_07930 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D2M30_07945 ENOG4107RIQ Sulfate adenylate transferase D2M30_07955 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D2M30_07960 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein D2M30_07965 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein D2M30_07975 ENOG4105F23 Fibronectin-binding protein D2M30_07985 ENOG4105DSJ YicC domain protein D2M30_07990 ENOG4105KC4 UPF0296 protein D2M30_07995 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D2M30_08005 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D2M30_08010 ENOG4105C25 Primosomal protein n' D2M30_08015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D2M30_08020 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D2M30_08025 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D2M30_08030 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D2M30_08035 ENOG4108ZF3 Phosphatase D2M30_08040 ENOG4105D9P serine threonine protein kinase D2M30_08045 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D2M30_08050 ENOG4105DJV ribulose-phosphate 3-epimerase D2M30_08055 ENOG4105FJ0 thiamine D2M30_08065 ENOG4105VB9 50S ribosomal protein l28 D2M30_08070 ENOG4108ZAA Alkaline-shock protein D2M30_08075 ENOG4105DP4 dak2 domain fusion protein ylov D2M30_08085 ENOG4105EJQ L-serine dehydratase D2M30_08090 ENOG4105CB5 ATP-dependent DNA helicase recG D2M30_08095 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) D2M30_08100 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D2M30_08105 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D2M30_08110 ENOG4105CHR reductase D2M30_08115 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D2M30_08120 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D2M30_08125 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D2M30_08130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D2M30_08135 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) D2M30_08145 ENOG4105K5M 30s ribosomal protein S16 D2M30_08150 ENOG4108BW8 UPF0109 protein D2M30_08170 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D2M30_08175 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) D2M30_08180 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D2M30_08190 ENOG4105VM1 flagellar D2M30_08195 ENOG4105CMV Succinyl-CoA synthetase subunit beta D2M30_08200 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D2M30_08205 ENOG4105C79 DNA protecting protein DprA D2M30_08210 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D2M30_08215 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) D2M30_08220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D2M30_08225 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D2M30_08230 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D2M30_08240 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D2M30_08245 ENOG4108ZC9 flagellar basal-body rod protein flgc D2M30_08250 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D2M30_08255 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D2M30_08260 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D2M30_08275 ENOG4106YF4 Flagellar biosynthesis chaperone D2M30_08285 ENOG410696Y Flagellar hook-length control protein D2M30_08290 ENOG410822I Flagellar hook capping protein D2M30_08295 ENOG4108JQA flagellar D2M30_08300 ENOG41068WV flagellar FlbD family protein D2M30_08310 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D2M30_08315 ENOG4105DD5 Flagellar motor switch protein D2M30_08320 ENOG4107YTP response regulator receiver protein D2M30_08330 ENOG4105CN7 Flagellar biosynthetic protein FliP D2M30_08335 ENOG4105VS8 Flagellar biosynthetic protein fliq D2M30_08340 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D2M30_08345 ENOG4105D00 flagellar biosynthetic protein flhB D2M30_08350 ENOG4105D7B Flagellar biosynthesis protein flha D2M30_08355 ENOG4105FZW flagellar biosynthesis regulator FlhF D2M30_08365 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D2M30_08370 ENOG4105CBS Chea signal transduction histidine kinase D2M30_08375 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis D2M30_08385 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) D2M30_08390 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_08400 ENOG4105CE9 30S ribosomal protein S2 D2M30_08410 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D2M30_08415 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D2M30_08420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D2M30_08425 ENOG4105KNE Phosphatidate cytidylyltransferase D2M30_08435 ENOG4105DZP Membrane-associated zinc metalloprotease D2M30_08440 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D2M30_08445 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D2M30_08450 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D2M30_08455 ENOG4105CHV Transcription elongation factor NusA D2M30_08460 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination D2M30_08465 ENOG4105VHM ribosomal protein D2M30_08470 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D2M30_08475 ENOG4105W7A Protein of unknown function (DUF503) D2M30_08480 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D2M30_08485 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D2M30_08490 ENOG4105DTN riboflavin biosynthesis protein ribF D2M30_08495 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D2M30_08500 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D2M30_08510 ENOG4105C1V Peptidase, M16 D2M30_08520 ENOG4105E35 Dipicolinate synthase subunit A D2M30_08525 ENOG4108S0H Dipicolinic acid synthetase, b subunit D2M30_08530 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D2M30_08540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D2M30_08550 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit D2M30_08560 ENOG4105CNU cell division protein FtsK D2M30_08565 ENOG4105FDP GntR family transcriptional regulator D2M30_08580 ENOG4105EYF MMPL domain protein D2M30_08595 ENOG4108RKS Short-chain dehydrogenase reductase Sdr D2M30_08600 ENOG4105XZV Protein of unknown function (DUF3243) D2M30_08615 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D2M30_08620 ENOG4105CEV competence damage-inducible protein D2M30_08625 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D2M30_08630 ENOG4108A04 Beta-lactamase D2M30_08640 ENOG4105D48 metallophosphoesterase D2M30_08645 ENOG4105MCT stage V sporulation protein S D2M30_08650 ENOG4105CPQ Dehydrogenase D2M30_08655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D2M30_08660 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D2M30_08680 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D2M30_08685 ENOG4108151 Beta-lactamase domain protein D2M30_08690 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D2M30_08695 ENOG4108JA1 polyketide synthase D2M30_08700 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D2M30_08705 ENOG41062T2 Acyl carrier protein D2M30_08710 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase D2M30_08715 ENOG4108MGH Enoyl-CoA hydratase D2M30_08720 ENOG4108KQ6 Enoyl-CoA hydratase D2M30_08725 ENOG4105C0W non-ribosomal peptide synthetase D2M30_08730 ENOG4107SQU synthase D2M30_08740 ENOG4105C0W non-ribosomal peptide synthetase D2M30_08750 ENOG4106A3M Cytochrome p-450 D2M30_08755 ENOG4105WFK nuclease D2M30_08760 ENOG4105XPP Protein of unknown function (DUF1275) D2M30_08770 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D2M30_08780 ENOG4105K7W phage-related replication protein D2M30_08785 ENOG4108X3M OsmC Ohr family protein D2M30_08810 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D2M30_08835 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D2M30_08840 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D2M30_08845 ENOG4105U6W MutT NUDIX family protein D2M30_08850 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D2M30_08860 ENOG4106F1P AAA ATPase, central domain protein D2M30_08865 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D2M30_08870 ENOG4105CXI aluminum resistance protein D2M30_08875 ENOG4105KV4 Transcriptional regulator D2M30_08880 ENOG4105C5F glutamine synthetase D2M30_08885 ENOG4107T94 Endo-14-beta-xylanase D2M30_08895 ENOG4105CT4 transporter D2M30_08900 ENOG4105DSG hydrolase family 43 D2M30_08910 ENOG4105C93 Xylose Isomerase D2M30_08915 ENOG4105CMG Carbohydrate kinase D2M30_08925 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D2M30_08960 ENOG4105DQ4 alcohol dehydrogenase D2M30_09020 ENOG4108M1A Chitin-binding protein D2M30_09045 ENOG4105YB8 TM2 domain containing protein D2M30_09050 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D2M30_09060 ENOG4105K7W phage-related replication protein D2M30_09080 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D2M30_09090 ENOG4108SVB resolvase D2M30_09095 ENOG4105VPS UPF0291 protein D2M30_09100 ENOG4105CV1 Transketolase (EC 2.2.1.1) D2M30_09110 ENOG4105VXM UPF0154 protein D2M30_09120 ENOG4107QIV Cytochrome c biogenesis protein D2M30_09155 ENOG4108I0Z Aconitate hydratase D2M30_09160 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D2M30_09175 ENOG41067CD Small, acid-soluble spore protein Tlp D2M30_09185 ENOG4105MI2 D2M30_09190 ENOG4105W8X HesB YadR YfhF-family protein D2M30_09195 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D2M30_09200 ENOG4105K4P CoA-binding domain protein D2M30_09205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D2M30_09235 ENOG4105FVX D2M30_09250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D2M30_09260 ENOG4107SYN Glycosyl hydrolases family 43 D2M30_09290 ENOG4105DTD Dehydrogenase D2M30_09295 ENOG4108IIH CoA-transferase subunit B D2M30_09300 ENOG4105D6N CoA-transferase, subunit a D2M30_09305 ENOG4106A3M Cytochrome p-450 D2M30_09310 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D2M30_09315 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D2M30_09320 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D2M30_09325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D2M30_09340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D2M30_09345 ENOG4107T5V SNARE associated Golgi D2M30_09350 ENOG4107QX3 carboxylase D2M30_09355 ENOG4105E39 Enoyl-CoA hydratase D2M30_09360 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D2M30_09365 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit D2M30_09370 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D2M30_09375 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_09380 ENOG4105C1G acyl-Coa dehydrogenase D2M30_09385 ENOG4105F32 YngK protein D2M30_09390 ENOG4106U2H Protein of unknown function (DUF1360) D2M30_09400 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_09405 ENOG4105C0W non-ribosomal peptide synthetase D2M30_09415 ENOG4105C0W non-ribosomal peptide synthetase D2M30_09425 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family D2M30_09430 ENOG4108N2V aldose 1-epimerase D2M30_09435 ENOG4107QJQ Mate efflux family protein D2M30_09490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D2M30_09495 ENOG4108RWP Major Facilitator Superfamily protein D2M30_09500 ENOG4105WAB arsR family transcriptional regulator D2M30_09505 ENOG4105C22 threonyL-tRNA synthetase D2M30_09510 ENOG4108KSA LysR family transcriptional regulator D2M30_09515 ENOG4105CB2 alcohol dehydrogenase D2M30_09525 ENOG4105BZ8 glutamate synthase D2M30_09530 ENOG4105CBC glutamate synthase D2M30_09535 ENOG4105C5Q Transcriptional regulator D2M30_09540 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D2M30_09565 ENOG4108UB7 D2M30_09570 ENOG4105IE8 Alpha-ketoglutarate permease D2M30_09575 ENOG4107U6E carbohydrate kinase FGGY D2M30_09580 ENOG4108M3J Dehydrogenase D2M30_09585 ENOG4108J2R molybdopterin oxidoreductase D2M30_09640 ENOG4108Z7R Chaperone CsaA D2M30_09645 ENOG4105FTV AraC Family Transcriptional Regulator D2M30_09655 ENOG4108W8B Beta-lactamase domain protein D2M30_09665 ENOG4105KTU Transcriptional regulator, arsr family D2M30_09675 ENOG4108SJC Membrane D2M30_09700 ENOG41069ER domain protein D2M30_09705 ENOG4105C9U ATP-dependent DNA helicase RecQ D2M30_09715 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D2M30_09720 ENOG4105SCY DNAK suppressor D2M30_09765 ENOG4105C26 Dehydrogenase D2M30_09770 ENOG4105EWU Squalene--hopene cyclase D2M30_09775 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D2M30_09780 ENOG4105C8J )-transporter D2M30_09785 ENOG4105C09 Bile acid D2M30_09795 ENOG4105C7S Dehydrogenase D2M30_09800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D2M30_09805 ENOG4107T89 von Willebrand factor, type A D2M30_09810 ENOG4105GMT ATPase associated with various cellular activities aaa_5 D2M30_09820 ENOG4105K4H Nlp p60 protein D2M30_09830 ENOG41087PP glycosyltransferase MGT family D2M30_09840 ENOG4107QMU Mate efflux family protein D2M30_09845 ENOG4106SCS STAS domain D2M30_09865 ENOG4105FR1 rard protein D2M30_09880 ENOG41090U3 tautomerase D2M30_09900 ENOG4105FBA Phospholipase Carboxylesterase D2M30_09915 ENOG4105E1V na solute symporter D2M30_09925 ENOG4105CS2 ec 3.2.1.21 D2M30_09930 ENOG4108S3Y transcriptional regulator D2M30_09950 ENOG4108VXD carboxy-peptidase D2M30_09955 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D2M30_09965 ENOG4106Z5R D2M30_09970 ENOG410841Q phosphoesterase PA-phosphatase related protein D2M30_09985 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily D2M30_10000 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D2M30_10005 ENOG4108TSC N-acetyltransferase D2M30_10010 ENOG4107S4Y M20 DapE family protein YgeY D2M30_10025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D2M30_10035 ENOG4105FTQ Dna gyrase D2M30_10110 ENOG4105C5E polysaccharide biosynthesis protein D2M30_10115 ENOG4105E0X reductase D2M30_10120 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D2M30_10130 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) D2M30_10135 ENOG41090WU lipolytic protein G-D-S-L family D2M30_10140 ENOG4108KF3 Electron transport protein SCO1 SenC D2M30_10150 ENOG4105C7B Threonine dehydratase D2M30_10160 ENOG4108UT2 hemolysin iii D2M30_10170 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D2M30_10175 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D2M30_10185 ENOG4107YX5 Pfam:DUF548 D2M30_10190 ENOG4108Y6J UPF0403 protein D2M30_10195 ENOG4105C01 Dihydroxy-acid dehydratase D2M30_10210 ENOG4108V06 Glutathione peroxidase D2M30_10215 ENOG4105CVG Homoserine O-transsuccinylase D2M30_10255 ENOG41081VK Ribonuclease D2M30_10280 ENOG410890F Dynamin family D2M30_10295 ENOG41065KQ synthase D2M30_10325 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) D2M30_10410 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D2M30_10450 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D2M30_10460 ENOG4106ITI Glutaredoxin D2M30_10495 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D2M30_10500 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D2M30_10575 ENOG4106J9J DNA polymerase D2M30_10585 ENOG4106IVX D2M30_10590 ENOG4106PTB DnaB-like helicase C terminal domain D2M30_10600 ENOG41088HM D2M30_10605 ENOG4106YR8 D2M30_10640 ENOG4105K7W phage-related replication protein D2M30_10670 ENOG4108RAV Conserved protein D2M30_10810 ENOG4107D0N D2M30_10870 ENOG4107NTZ D2M30_10935 ENOG4108NE4 D2M30_10990 ENOG4105K70 DNA-binding protein D2M30_11080 ENOG41068G1 D2M30_11140 ENOG4105EKQ RNA-directed DNA polymerase D2M30_11200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D2M30_11205 ENOG4105EKQ RNA-directed DNA polymerase D2M30_11220 ENOG4108YTE sporulation protein YunB D2M30_11240 ENOG4106BHF D2M30_11255 ENOG4107Y9E nuclease D2M30_11270 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) D2M30_11275 ENOG4105CTD carboxy-peptidase D2M30_11280 ENOG4105DVT helicase D2M30_11295 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D2M30_11305 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) D2M30_11310 ENOG4108UKS UPF0398 protein D2M30_11320 ENOG4107X2U Inherit from COG: Exonuclease-like protein D2M30_11325 ENOG4108I5C dEAD DEAH box helicase D2M30_11370 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) D2M30_11375 ENOG4105BZ4 penicillin-binding protein D2M30_11385 ENOG4105CSM endonuclease III D2M30_11395 ENOG4105C5S asparaginyl-tRNA synthetase D2M30_11400 ENOG4105CHM Aminotransferase D2M30_11410 ENOG4105YAC D2M30_11415 ENOG4105DVT helicase D2M30_11420 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D2M30_11430 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D2M30_11440 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D2M30_11445 ENOG4105CPK Glycosyl transferase (Group 1 D2M30_11450 ENOG4105FJR Lmbe family D2M30_11455 ENOG4108Z5K methylglyoxal synthase D2M30_11460 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D2M30_11465 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase D2M30_11470 ENOG4108JYZ YitT family D2M30_11475 ENOG4105F0F Oxalate decarboxylase D2M30_11495 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D2M30_11515 ENOG41068YB TPR repeat-containing protein D2M30_11520 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D2M30_11530 ENOG4105CIH Imidazole acetol-phosphate transaminase D2M30_11540 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D2M30_11545 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D2M30_11550 ENOG4105DK0 Indole-3-glycerol phosphate synthase D2M30_11560 ENOG4105CRQ synthase (Component I) D2M30_11565 ENOG4105KHN chorismate mutase D2M30_11575 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D2M30_11580 ENOG4105BZU Histidine kinase D2M30_11585 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D2M30_11590 ENOG4105EAH synthase D2M30_11595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D2M30_11600 ENOG4105XXQ heptaprenyl diphosphate synthase component I D2M30_11605 ENOG4105WP2 Tryptophan RNA-binding attenuator protein D2M30_11610 ENOG4105EUJ GTP cyclohydrolase i D2M30_11615 ENOG4105K70 DNA-binding protein D2M30_11620 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) D2M30_11635 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D2M30_11640 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D2M30_11660 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D2M30_11665 ENOG4105CAT Cytidine monophosphate kinase D2M30_11675 ENOG4105MSI germination protein ypeb D2M30_11685 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) D2M30_11690 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase D2M30_11705 ENOG4107RGJ metallophosphoesterase D2M30_11720 ENOG4105I7S Abortive infection protein D2M30_11725 ENOG4105C9U ATP-dependent DNA helicase RecQ D2M30_11730 ENOG4105T7X D2M30_11740 ENOG4108SAX Membrane D2M30_11745 ENOG4108JQ1 Dehydrogenase D2M30_11760 ENOG4105BZU Histidine kinase D2M30_11765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D2M30_11770 ENOG4105CRE cytochrome C D2M30_11775 ENOG4107TWT Cytochrome c biogenesis protein D2M30_11785 ENOG4105FE9 pseudouridine synthase D2M30_11795 ENOG4108JIC nucleoside recognition domain protein D2M30_11800 ENOG4105DZ1 carboxypeptidase D2M30_11810 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D2M30_11815 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D2M30_11840 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D2M30_11845 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D2M30_11850 ENOG4108R6K riboflavin synthase, subunit alpha D2M30_11875 ENOG4107ZE5 PPIases accelerate the folding of proteins D2M30_11880 ENOG4105PTM secreted protein D2M30_11885 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D2M30_11895 ENOG4105G6R Stage v sporulation protein ae D2M30_11905 ENOG4105CZ3 stage V sporulation protein ad D2M30_11910 ENOG41090VF Stage v sporulation protein ac D2M30_11925 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_11930 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) D2M30_11935 ENOG41082AN stage II sporulation protein D2M30_11940 ENOG4105DZ1 carboxypeptidase D2M30_11945 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) D2M30_11950 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D2M30_11955 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D2M30_11965 ENOG4105I3K Ferric uptake regulator, Fur family D2M30_11970 ENOG4105MZ9 stage II sporulation protein m D2M30_11990 ENOG4105DFD Na H antiporter D2M30_11995 ENOG4108IJ0 Aspartate ammonia-lyase D2M30_12000 ENOG4105HDK L-asparaginase D2M30_12005 ENOG4108IMY Transcriptional regulator D2M30_12015 ENOG4108YZ4 nudix hydrolase D2M30_12025 ENOG4105CPC Aldo Keto reductase D2M30_12045 ENOG4106HZJ D2M30_12050 ENOG4105RHY Pfam:UPF0157 D2M30_12055 ENOG4108XET gCN5-related N-acetyltransferase D2M30_12060 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D2M30_12075 ENOG4105C02 permease D2M30_12085 ENOG4105CS9 pantothenic acid kinase D2M30_12095 ENOG4108IXY short-chain dehydrogenase reductase D2M30_12100 ENOG41069FQ Metallo-beta-lactamase superfamily D2M30_12105 ENOG4105II7 pyrroline-5-carboxylate reductase D2M30_12110 ENOG4107QKG PfaD family D2M30_12115 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D2M30_12125 ENOG4108K70 Transcriptional regulator D2M30_12135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D2M30_12145 ENOG410861F 50S ribosomal protein L33 D2M30_12150 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D2M30_12155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D2M30_12160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D2M30_12165 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D2M30_12175 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) D2M30_12180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D2M30_12185 ENOG4108HNZ carboxyl transferase D2M30_12190 ENOG4108ZVT methylmalonyl-coA epimerase D2M30_12195 ENOG4108VZI ErfK ybiS ycfS ynhG family protein D2M30_12200 ENOG4108QEG Membrane D2M30_12205 ENOG4105CDA abc transporter atp-binding protein D2M30_12210 ENOG4105E5Q amino acid AbC transporter D2M30_12215 ENOG4108HW3 (ABC) transporter D2M30_12220 ENOG4108Y6J UPF0403 protein D2M30_12225 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) D2M30_12230 ENOG4105C7S Dehydrogenase D2M30_12235 ENOG4105CPP Dehydrogenase, E1 component D2M30_12250 ENOG4105CKM Branched-chain carboxylic acid kinase D2M30_12255 ENOG4107RDP Dehydrogenase D2M30_12265 ENOG4108JUB Transcriptional regulator D2M30_12270 ENOG4106CCJ Protein of unknown function (DUF2627) D2M30_12275 ENOG4105CR4 methylisocitrate lyase D2M30_12280 ENOG4105DXD 2-methylcitrate dehydratase D2M30_12290 ENOG4105C1G acyl-Coa dehydrogenase D2M30_12295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D2M30_12305 ENOG4108QXE glycerophosphoryl diester phosphodiesterase D2M30_12310 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D2M30_12345 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D2M30_12350 ENOG4107QQR Sporulation D2M30_12355 ENOG4105S1Z Stage IV sporulation protein B D2M30_12360 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D2M30_12365 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) D2M30_12370 ENOG4105DX0 Hemolysin A D2M30_12375 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D2M30_12380 ENOG4105CTB Polyprenyl synthetase D2M30_12385 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D2M30_12390 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D2M30_12395 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D2M30_12400 ENOG4105M7K Involved in the transcription termination process (By similarity) D2M30_12405 ENOG4108ZSR alkaline shock protein D2M30_12410 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D2M30_12430 ENOG410644B Stage III sporulation protein af D2M30_12440 ENOG4105KQ4 Stage iii sporulation protein ad D2M30_12445 ENOG4108CQH stage III sporulation protein AC D2M30_12450 ENOG4105KR5 Stage iii sporulation protein D2M30_12455 ENOG4105CD2 stage iii sporulation protein aa D2M30_12465 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D2M30_12470 ENOG4105DC7 peptidase M24 D2M30_12480 ENOG4105CBJ Metal-dependent enzyme D2M30_12500 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) D2M30_12505 ENOG4105WZW rhodanese family D2M30_12510 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D2M30_12520 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D2M30_12525 ENOG4105C0D helicase D2M30_12540 ENOG4108IMY Transcriptional regulator D2M30_12550 ENOG4105VFR signal peptidase D2M30_12610 ENOG4105C37 (CBS) domain D2M30_12635 ENOG4105C5X domain protein D2M30_12680 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D2M30_12685 ENOG4105WDJ 50S ribosomal protein L33 D2M30_12695 ENOG41068DG YceG-like family D2M30_12700 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D2M30_12705 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D2M30_12710 ENOG4105E2Z phosphate ABC transporter (Permease D2M30_12715 ENOG4105C8U phosphate abc transporter D2M30_12720 ENOG4105CVA phosphate D2M30_12725 ENOG4107RF6 penicillin-binding protein D2M30_12735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D2M30_12740 ENOG4105SXS Protein of unknown function (DUF456) D2M30_12755 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D2M30_12760 ENOG41063Y9 D2M30_12765 ENOG4108U5J '-nucleotidase D2M30_12770 ENOG4105N80 Ferric uptake regulator, Fur family D2M30_12780 ENOG41069ZM Protein of unknown function (DUF2624) D2M30_12785 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D2M30_12800 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D2M30_12805 ENOG4105EGD dinuclear metal center protein, YbgI family D2M30_12820 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_12825 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D2M30_12830 ENOG4108UPT UPF0178 protein D2M30_12835 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D2M30_12845 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D2M30_12850 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D2M30_12855 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) D2M30_12865 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D2M30_12870 ENOG4105KG3 cytidine deaminase D2M30_12875 ENOG4107YR5 Diacylglycerol kinase D2M30_12880 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D2M30_12885 ENOG4105CTJ Metal Dependent Phosphohydrolase D2M30_12890 ENOG4105C9A Phoh family D2M30_12895 ENOG4105EI1 sporulation protein yqfd D2M30_12900 ENOG41068P3 sporulation protein YqfC D2M30_12910 ENOG4105DI5 UPF0365 protein D2M30_12915 ENOG4105F7J membrane-bound serine protease D2M30_12920 ENOG4105KTH gatB Yqey D2M30_12935 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D2M30_12940 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D2M30_12945 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D2M30_12950 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D2M30_12955 ENOG4105CFG Acts as a chaperone (By similarity) D2M30_12960 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D2M30_12965 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D2M30_12970 ENOG4105CSA Coproporphyrinogen iii oxidase D2M30_12975 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D2M30_12985 ENOG4108ZRV stage ii sporulation protein p D2M30_12990 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) D2M30_12995 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) D2M30_13000 ENOG4105TQK DNA polymerase iii, delta' subunit D2M30_13010 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 D2M30_13015 ENOG4108UK2 deaminase D2M30_13020 ENOG4105KQC Competence protein D2M30_13030 ENOG4108D32 Methyltransferase D2M30_13040 ENOG4108WF2 Metal Dependent Phosphohydrolase D2M30_13045 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D2M30_13050 ENOG410812S Rna-binding protein D2M30_13055 ENOG4105E2X shikimate dehydrogenase D2M30_13060 ENOG4105CQW ribosome biogenesis GTPase YqeH D2M30_13065 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase D2M30_13085 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase D2M30_13090 ENOG41080BT SNARE associated Golgi D2M30_13105 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_13130 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_13155 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D2M30_13165 ENOG4108J8C transporter major facilitator family protein D2M30_13185 ENOG4105DQF Hydrolase D2M30_13190 ENOG4108HCJ Hydrolase D2M30_13200 ENOG4105DG6 mannose-6-phosphate isomerase D2M30_13205 ENOG4105DM4 PTS System D2M30_13220 ENOG4108Z66 YbaK ebsC protein D2M30_13225 ENOG4107RSM transcriptional regulator D2M30_13230 ENOG4105D94 Major Facilitator Superfamily D2M30_13235 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D2M30_13240 ENOG41082JN Transcriptional regulator D2M30_13255 ENOG4105TMB Formate nitrite transporter D2M30_13260 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) D2M30_13265 ENOG4108JB9 formate dehydrogenase D2M30_13280 ENOG4105C28 cystathionine D2M30_13310 ENOG4107XRG penicillin-binding protein D2M30_13315 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D2M30_13345 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase D2M30_13365 ENOG41068G1 D2M30_13375 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D2M30_13385 ENOG4108FKH Transglycosylase SLT domain D2M30_13480 ENOG410682Q Phage transcriptional regulator, ArpU D2M30_13595 ENOG4105CFP Peptidase U32 D2M30_13600 ENOG4105XYU peptidase (U32 family) D2M30_13605 ENOG4108VQJ O-methyltransferase D2M30_13610 ENOG4105HHA aminodeoxychorismate lyase D2M30_13620 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D2M30_13625 ENOG4105VBH UPF0297 protein D2M30_13630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D2M30_13635 ENOG4105C02 permease D2M30_13640 ENOG4105CDA abc transporter atp-binding protein D2M30_13645 ENOG4105CT1 (ABC) transporter D2M30_13650 ENOG4105EAD ABC transporter D2M30_13655 ENOG4105DRP amino acid AbC transporter D2M30_13665 ENOG41060CR D2M30_13675 ENOG4105C7H Helicase, RecD TraA family D2M30_13685 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D2M30_13690 ENOG4105C3J Cysteine desulfurase D2M30_13700 ENOG4105D1H recombination factor protein RarA D2M30_13705 ENOG4105CUZ uba thif-type nad fad binding protein D2M30_13715 ENOG4105C9M aspartyl-trna synthetase D2M30_13720 ENOG4105CUT histidyl-tRNA synthetase D2M30_13730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D2M30_13735 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D2M30_13740 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D2M30_13750 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D2M30_13755 ENOG41067VP Protein of unknown function (DUF1049) D2M30_13760 ENOG4105NCW Trka-c domain protein D2M30_13765 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D2M30_13775 ENOG4105CKP Polysaccharide Biosynthesis Protein D2M30_13780 ENOG4108QG2 Membrane D2M30_13785 ENOG4105NAP D2M30_13790 ENOG4105VIE preprotein translocase, subunit YajC D2M30_13795 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D2M30_13800 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D2M30_13805 ENOG41061AI Protein of unknown function (DUF2905) D2M30_13810 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D2M30_13815 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D2M30_13830 ENOG4106678 morphogenetic protein associated with SpoVID D2M30_13835 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D2M30_13840 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D2M30_13845 ENOG4108IYU L-aspartate oxidase D2M30_13860 ENOG4105CQC Prephenate dehydratase D2M30_13870 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D2M30_13880 ENOG4105K46 50S ribosomal protein l27 D2M30_13885 ENOG4105X36 (ribosomal) protein D2M30_13890 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D2M30_13905 ENOG4107QMS site-determining protein D2M30_13910 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D2M30_13915 ENOG4105YHC Rod shape-determining protein MreD D2M30_13920 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D2M30_13925 ENOG4105DFF Rod shape-determining protein mreb D2M30_13930 ENOG4105W5Q DNA repair protein (RadC D2M30_13935 ENOG4108Z03 MAF-like protein D2M30_13945 ENOG4106A3R peptidase D2M30_13950 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D2M30_13955 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D2M30_13965 ENOG4106AR7 Spore coat protein D2M30_13970 ENOG41068KH stage VI sporulation protein D D2M30_13975 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D2M30_13980 ENOG4105D52 delta-aminolevulinic acid dehydratase D2M30_13990 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D2M30_14000 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D2M30_14010 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D2M30_14015 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D2M30_14020 ENOG4108IUQ atp-dependent protease D2M30_14025 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D2M30_14030 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D2M30_14040 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D2M30_14045 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D2M30_14050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D2M30_14060 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D2M30_14065 ENOG4108ZP8 Acetolactate synthase small subunit D2M30_14070 ENOG4105C7K acetolactate synthase D2M30_14095 ENOG4105M59 Phosphodiesterase, mj0936 family D2M30_14100 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D2M30_14105 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D2M30_14110 ENOG4108XJQ germination protein D2M30_14115 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D2M30_14120 ENOG41067TZ transcriptional regulator, MarR family D2M30_14125 ENOG4105PFC Transcriptional regulator D2M30_14135 ENOG4105E33 succinate dehydrogenase D2M30_14145 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit D2M30_14155 ENOG4105CFH Aspartokinase D2M30_14160 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D2M30_14165 ENOG4105K63 Thioredoxin D2M30_14170 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D2M30_14175 ENOG4105C10 Electron transfer flavoprotein D2M30_14180 ENOG4105BZJ Electron transfer flavoprotein D2M30_14185 ENOG41060WC Enoyl-CoA hydratase D2M30_14190 ENOG4107Z3H Transcriptional regulator, TetR family D2M30_14195 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_14210 ENOG4105C98 muts2 protein D2M30_14215 ENOG4105DCG PHP domain protein D2M30_14230 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D2M30_14235 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D2M30_14240 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D2M30_14245 ENOG4108RWN rrna methyltransferase D2M30_14250 ENOG41067MF small acid-soluble spore protein D2M30_14265 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D2M30_14275 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) D2M30_14280 ENOG4105DRS transport system, permease D2M30_14295 ENOG4108MDK Dehydrogenase D2M30_14305 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D2M30_14310 ENOG4105EF1 ribulokinase D2M30_14320 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase D2M30_14325 ENOG4105CN9 Peptidase m42 family protein D2M30_14335 ENOG410696E Membrane D2M30_14340 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D2M30_14345 ENOG4105VJV 50s ribosomal protein L35 D2M30_14350 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D2M30_14355 ENOG41067MG lrgb family D2M30_14365 ENOG4105DY9 regulatoR D2M30_14370 ENOG4108HRK Histidine kinase D2M30_14375 ENOG4105U0R haloacid dehalogenase-like hydrolase D2M30_14380 ENOG4105C22 threonyL-tRNA synthetase D2M30_14385 ENOG4108TDW sporulation protein YtxC D2M30_14410 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) D2M30_14415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D2M30_14420 ENOG4105KVH Transcriptional regulator D2M30_14425 ENOG4105F27 Major Facilitator D2M30_14430 ENOG4105CV8 reductase D2M30_14435 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D2M30_14445 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D2M30_14450 ENOG4105C2M dna polymerase I D2M30_14455 ENOG4105BZU Histidine kinase D2M30_14460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D2M30_14470 ENOG4108HMX isocitrate dehydrogenase (NADP) D2M30_14475 ENOG4105BZN citrate synthase D2M30_14485 ENOG4108REF Sporulation integral membrane protein ytvi D2M30_14490 ENOG4105FS0 cytoplasmic membrane protein D2M30_14495 ENOG4105CA9 Pyruvate kinase D2M30_14500 ENOG4105CTQ phosphohexokinase D2M30_14505 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D2M30_14510 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D2M30_14515 ENOG4105C6K Malic enzyme D2M30_14520 ENOG4105C0B DNA polymerase III (alpha subunit) D2M30_14525 ENOG4105VV2 D2M30_14535 ENOG4106EVM D2M30_14540 ENOG4105SFS phosphoesterase RecJ domain protein D2M30_14555 ENOG4105E8R UPF0173 metal-dependent hydrolase D2M30_14565 ENOG4105CH7 arginosuccinase D2M30_14570 ENOG4105CDH Citrulline--aspartate ligase D2M30_14575 ENOG4105EPU Molybdenum cofactor synthesis domain protein D2M30_14580 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D2M30_14590 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D2M30_14595 ENOG4105KBJ sporulation protein ytfj D2M30_14605 ENOG4105VK3 rdd domain containing protein D2M30_14610 ENOG4105D07 Signal peptide peptidase, SppA D2M30_14615 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D2M30_14620 ENOG4105EFZ amidohydrolase D2M30_14625 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D2M30_14635 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D2M30_14660 ENOG4105U5Y Transcriptional regulator D2M30_14670 ENOG4105BZU Histidine kinase D2M30_14680 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D2M30_14685 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D2M30_14715 ENOG4108NGU Transcriptional regulator D2M30_14720 ENOG4108UMN azlc family D2M30_14730 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D2M30_14740 ENOG4105F1V Acetoin utilization protein D2M30_14745 ENOG4105W87 Cbs domain D2M30_14750 ENOG4105DGU Histone deacetylase D2M30_14755 ENOG4105ER2 Ompa motb domain protein D2M30_14760 ENOG4107R0U MotA TolQ exbB proton channel D2M30_14765 ENOG4105ETE Transcriptional regulator (LacI family D2M30_14770 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D2M30_14790 ENOG4105DFU Cell wall formation (By similarity) D2M30_14800 ENOG4108VDD TRNA binding domain protein D2M30_14815 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ D2M30_14830 ENOG4105C6K Malic enzyme D2M30_14835 ENOG4105C8F Beta-lactamase domain protein D2M30_14840 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D2M30_14850 ENOG4108V15 phosphotransferase enzyme family D2M30_14865 ENOG4107F58 2'-5' rna ligase D2M30_14870 ENOG4105C6T cysteine synthase D2M30_14875 ENOG4107QSE Dipeptidase D2M30_14880 ENOG4105C7N Xanthine uracil vitamin C permease D2M30_14895 ENOG4105YW5 deoR family transcriptional regulator D2M30_14910 ENOG4105CBX hi0933 family D2M30_14915 ENOG4105C94 Transporter D2M30_14935 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component D2M30_14940 ENOG4105I1K ABC transporter D2M30_14955 ENOG41085GJ domain protein D2M30_14960 ENOG4105C8T Leucyl-tRNA synthetase D2M30_14970 ENOG4105BZU Histidine kinase D2M30_14975 ENOG410605W Major Facilitator D2M30_14990 ENOG4105C19 ABC transporter D2M30_14995 ENOG4105EWM Histidine kinase D2M30_15005 ENOG4107R34 abc transporter permease protein D2M30_15010 ENOG4105C19 ABC transporter D2M30_15030 ENOG4105DVE abc transporter atp-binding protein D2M30_15035 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family D2M30_15045 ENOG4105N5T Radical SAM Protein D2M30_15065 ENOG4105E8V Alpha Beta Hydrolase Fold protein D2M30_15070 ENOG4108Z0R Transferase D2M30_15075 ENOG4105C85 amino acid D2M30_15080 ENOG4105CAQ asparagine synthetase D2M30_15085 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D2M30_15090 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D2M30_15105 ENOG4105D2X ABC transporter substrate-binding protein D2M30_15115 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component D2M30_15130 ENOG4108RMU ferritin dps family protein D2M30_15145 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D2M30_15150 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D2M30_15155 ENOG4108V2W Carbonate dehydratase D2M30_15160 ENOG4105NRA 50s ribosomal protein l31 type b D2M30_15180 ENOG4105DTQ mandelate racemase muconate lactonizing D2M30_15185 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_15190 ENOG4108IPT Naphthoate synthase D2M30_15195 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D2M30_15200 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D2M30_15205 ENOG4105E4F Isochorismate synthase D2M30_15340 ENOG4105N67 Proton-coupled thiamine transporter YuaJ D2M30_15345 ENOG4105DZ6 Band 7 protein D2M30_15355 ENOG4106DF1 D2M30_15360 ENOG4108VNY MOSC domain protein D2M30_15365 ENOG4108JB8 alcohol dehydrogenase D2M30_15370 ENOG4105C26 Dehydrogenase D2M30_15375 ENOG4105TRT Transcriptional regulator D2M30_15390 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D2M30_15395 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D2M30_15415 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D2M30_15425 ENOG4105EE0 oxidoreductase D2M30_15430 ENOG4108Z0Z intracellular protease Pfpi family D2M30_15435 ENOG4105C8Q Methyl-accepting chemotaxis D2M30_15440 ENOG4105C8Q Methyl-accepting chemotaxis D2M30_15445 ENOG4105C8Q Methyl-accepting chemotaxis D2M30_15450 ENOG4105C8Q Methyl-accepting chemotaxis D2M30_15465 ENOG4105EA8 2-Nitropropane dioxygenase D2M30_15470 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme D2M30_15480 ENOG4105C37 (CBS) domain D2M30_15495 ENOG4107PBV potassium channel D2M30_15500 ENOG4107PBV potassium channel D2M30_15515 ENOG4107QYV phosphohexose isomerase D2M30_15525 ENOG4105CHJ isochorismatase hydrolase D2M30_15535 ENOG4107QW4 alcohol dehydrogenase D2M30_15540 ENOG4105WG9 Conserved Protein D2M30_15550 ENOG4105CHM Aminotransferase D2M30_15555 ENOG4108ZB6 transcriptional regulator AsnC family D2M30_15560 ENOG4108MUZ hydrolase D2M30_15570 ENOG4105C87 Aminotransferase class I and II D2M30_15575 ENOG4108HGU Histidine kinase D2M30_15580 ENOG4105Y38 Kinase-associated protein B D2M30_15595 ENOG4105BZ4 penicillin-binding protein D2M30_15600 ENOG4105KIR Thiol-disulfide oxidoreductase dcc D2M30_15615 ENOG4108MRH transcriptional regulatory protein D2M30_15620 ENOG4105DIH basic membrane D2M30_15625 ENOG4108JQ9 ABC transporter D2M30_15630 ENOG4105UIB (ABC) transporter D2M30_15645 ENOG4105D65 subunit l D2M30_15650 ENOG4105HC0 Na H antiporter D2M30_15655 ENOG4108ZE9 Monovalent cation H antiporter subunit C D2M30_15660 ENOG4108JPZ Monovalent cation H antiporter subunit D D2M30_15665 ENOG4105SC1 monovalent cation H antiporter subunit E D2M30_15675 ENOG4105KJM monovalent cation h antiporter subunit g D2M30_15680 ENOG4105KA0 thioesterase Superfamily protein D2M30_15690 ENOG4105BZU Histidine kinase D2M30_15720 ENOG4105D58 Diguanylate phosphodiesterase D2M30_15725 ENOG4105DAP Nicotinate phosphoribosyltransferase D2M30_15750 ENOG4105C02 permease D2M30_15765 ENOG410904N short-chain dehydrogenase reductase D2M30_15800 ENOG4108K8K Transcriptional regulator D2M30_15805 ENOG4105DCF alanine dehydrogenase D2M30_15815 ENOG4105WQT MbtH domain protein D2M30_15820 ENOG4105CEY Amp-dependent synthetase and ligase D2M30_15825 ENOG4105WQI isochorismatase D2M30_15830 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D2M30_15835 ENOG4105E4F Isochorismate synthase D2M30_15840 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D2M30_15845 ENOG4105NIV Esterase D2M30_15865 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D2M30_15875 ENOG41069ER domain protein D2M30_15890 ENOG4105CEP NADH dehydrogenase D2M30_15905 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) D2M30_15915 ENOG4108VHC Short-chain dehydrogenase reductase Sdr D2M30_15920 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D2M30_15925 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D2M30_15935 ENOG4105ZKE UPF0349 protein D2M30_15950 ENOG41083MR nifu domain-containing protein D2M30_15955 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein D2M30_15960 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D2M30_15965 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) D2M30_15970 ENOG4105D6E homoserine dehydrogenase D2M30_15980 ENOG4108W5N phosphatidylglycerophosphatase a D2M30_15985 ENOG4105D4U had-superfamily hydrolase, subfamily iia D2M30_15995 ENOG4105MMD transcriptional regulator D2M30_16005 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D2M30_16010 ENOG4105FAA peptidase M23 D2M30_16015 ENOG4108YTE sporulation protein YunB D2M30_16020 ENOG4107R8B 5'-nucleotidase D2M30_16030 ENOG4105I3N Conserved Protein D2M30_16040 ENOG4105CD3 dihydroorotase D2M30_16045 ENOG4105G9B Transcriptional regulator D2M30_16070 ENOG4105C5R Aminotransferase D2M30_16080 ENOG4108K8S endonuclease I D2M30_16090 ENOG4105FDP GntR family transcriptional regulator D2M30_16095 ENOG4105FDP GntR family transcriptional regulator D2M30_16105 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component D2M30_16110 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component D2M30_16115 ENOG4105XN3 extracellular solute-binding protein family 1 D2M30_16120 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine D2M30_16150 ENOG4105PKS Excinuclease abc c subunit domain protein D2M30_16155 ENOG4107VFR oxidoreductase D2M30_16170 ENOG41083Q9 chitosanase D2M30_16175 ENOG4105DIW FeS assembly protein SUFB D2M30_16180 ENOG4108UNV SUF system FeS assembly protein, NifU family D2M30_16185 ENOG4105C9B Cysteine desulfurase D2M30_16190 ENOG4105JRK feS assembly protein SufD D2M30_16195 ENOG4105C3K feS assembly ATPase SufC D2M30_16215 ENOG4105D01 (LipO)protein D2M30_16220 ENOG4108UMI ABC transporter, permease D2M30_16225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D2M30_16250 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D2M30_16255 ENOG41080E8 Transcriptional regulator, Spx MgsR family D2M30_16260 ENOG4105C1G acyl-Coa dehydrogenase D2M30_16265 ENOG4105CHU acetyl-coa acetyltransferase D2M30_16295 ENOG41067TZ transcriptional regulator, MarR family D2M30_16300 ENOG4105C0R drug resistance transporter emrb qaca subfamily D2M30_16305 ENOG4105MDS 4-oxalocrotonate tautomerase D2M30_16315 ENOG4105EGI Transcriptional regulator D2M30_16325 ENOG4105E0A ABC, transporter D2M30_16340 ENOG4105E1F short-chain dehydrogenase reductase D2M30_16345 ENOG4105HUF DNA protection during starvation protein D2M30_16350 ENOG4105C0H protease D2M30_16360 ENOG4105F3H Histidine kinase D2M30_16370 ENOG41067SE Tetr family transcriptional regulator D2M30_16375 ENOG4105C9Q fumarate hydratase class II D2M30_16400 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_16405 ENOG4105ENE Histidine kinase D2M30_16420 ENOG41087YS Phage shock protein A D2M30_16435 ENOG4108WBT adenosyltransferase D2M30_16440 ENOG4105E0A ABC, transporter D2M30_16445 ENOG4105EHG Permease protein D2M30_16450 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D2M30_16455 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D2M30_16460 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein D2M30_16470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D2M30_16480 ENOG4106DF4 Sigma-70, region 4 D2M30_16490 ENOG4105F0F Oxalate decarboxylase D2M30_16500 ENOG4105E0A ABC, transporter D2M30_16505 ENOG4105EHG Permease protein D2M30_16510 ENOG4105DQ5 transport system permease protein D2M30_16520 ENOG4105JQZ Methyltransferase D2M30_16525 ENOG4105D5Q Arginine ornithine antiporter D2M30_16540 ENOG4107K5X Membrane-bound metal-dependent hydrolase D2M30_16545 ENOG4107QZ2 Sulfatase D2M30_16550 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family D2M30_16555 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D2M30_16560 ENOG4105E0C molybdate abc transporter D2M30_16565 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_16575 ENOG4105CJ1 ABC, transporter D2M30_16585 ENOG4108KYE ABC-2 type transporter D2M30_16600 ENOG4105EEQ Na H antiporter D2M30_16605 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D2M30_16610 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D2M30_16615 ENOG4105EEM helicase D2M30_16620 ENOG4105EN6 Membrane D2M30_16635 ENOG4107ZQN disulfide bond D2M30_16640 ENOG4105C59 p-type ATPase D2M30_16645 ENOG4105C59 p-type ATPase D2M30_16650 ENOG410681U heavy metal transport detoxification protein D2M30_16655 ENOG4105VPX protein, conserved in bacteria D2M30_16660 ENOG4105D9R oxidoreductase D2M30_16665 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D2M30_16700 ENOG4105DEN Luciferase family D2M30_16705 ENOG4105CDA abc transporter atp-binding protein D2M30_16730 ENOG4108XSB acetyltransferase, (GNAT) family D2M30_16735 ENOG4108KSA LysR family transcriptional regulator D2M30_16740 ENOG4105EWI Short-chain dehydrogenase reductase Sdr D2M30_16745 ENOG41067XF inhibitor D2M30_16755 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D2M30_16760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D2M30_16770 ENOG4105XZU Preprotein translocase, subunit SecG D2M30_16790 ENOG4105KVH Transcriptional regulator D2M30_16815 ENOG4105DA5 (ABC) transporter D2M30_16820 ENOG4105R40 Glycine betaine carnitine choline D2M30_16825 ENOG4108HQR Glycine betaine D2M30_16830 ENOG4105E90 ABC transporter D2M30_16835 ENOG4108IJ8 ABC transporter D2M30_16840 ENOG4107HG4 Transcriptional regulator D2M30_16845 ENOG4105R40 Glycine betaine carnitine choline D2M30_16850 ENOG4108HQR Glycine betaine D2M30_16855 ENOG4105E90 ABC transporter D2M30_16860 ENOG4108IJ8 ABC transporter D2M30_16865 ENOG4107HG4 Transcriptional regulator D2M30_16870 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D2M30_16880 ENOG4105T65 Membrane-associated protein D2M30_16885 ENOG4108W0I acetyltransferase D2M30_16900 ENOG4105FJR Lmbe family D2M30_16920 ENOG4108IAJ Nad-dependent epimerase dehydratase D2M30_16925 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D2M30_16930 ENOG4107QQG Dehydrogenase D2M30_16935 ENOG4105IIU Aminopeptidase D2M30_16940 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D2M30_16945 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D2M30_16950 ENOG4105CP7 Triose-phosphate isomerase D2M30_16955 ENOG4105BZA Phosphoglycerate kinase D2M30_16965 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D2M30_16980 ENOG4105CMD Transcriptional regulator, GntR family D2M30_16985 ENOG4105DEN Luciferase family D2M30_16995 ENOG4105GZI Transcriptional regulator D2M30_17000 ENOG4107RT3 EamA-like transporter family D2M30_17010 ENOG4106KNT transcriptional regulator D2M30_17015 ENOG4105CMG Carbohydrate kinase D2M30_17020 ENOG4105C6Z Gluconate D2M30_17030 ENOG4107QR9 Iron-sulfur cluster binding protein D2M30_17035 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D2M30_17040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D2M30_17045 ENOG4105JXH GntR family transcriptional regulator D2M30_17050 ENOG4105DAA L-lactate D2M30_17055 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D2M30_17065 ENOG4108ZPC Polysaccharide pyruvyl transferase D2M30_17070 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D2M30_17075 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family D2M30_17080 ENOG4105D3Q Sugar transferase D2M30_17090 ENOG4105K64 Glycosyl transferase, family 2 D2M30_17100 ENOG4107QRS glycosyltransferase group 2 family protein D2M30_17105 ENOG41068W6 Capsular polysaccharide biosynthesis protein D2M30_17110 ENOG4108KMV Glycosyl transferase (Group 1 D2M30_17115 ENOG4105K64 Glycosyl transferase, family 2 D2M30_17120 ENOG4108PQP glycosyl transferase group 1 D2M30_17130 ENOG4108QV3 biosynthesis protein D2M30_17135 ENOG4105HTX biosynthesis protein D2M30_17145 ENOG4105EBR Carboxylesterase D2M30_17155 ENOG4105NAE bifunctional deaminase-reductase domain protein D2M30_17160 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) D2M30_17180 ENOG4105PY6 Phenolic acid decarboxylase D2M30_17185 ENOG4105NI3 Protein of unknown function (DUF3237) D2M30_17220 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D2M30_17230 ENOG4105ETE Transcriptional regulator (LacI family D2M30_17235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D2M30_17240 ENOG4108KAM Transcriptional regulator D2M30_17245 ENOG4105C7F AcnD-accessory protein PrpF D2M30_17260 ENOG4108URH decarboxylase D2M30_17265 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain D2M30_17270 ENOG4105CHH sulfate transporter D2M30_17275 ENOG4108V2W Carbonate dehydratase D2M30_17285 ENOG4105C5I Dehydrogenase D2M30_17290 ENOG4105GGE ribonuclease D2M30_17295 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase D2M30_17300 ENOG4105KRI phosphocarrier protein (HPr D2M30_17305 ENOG4105CIE May be required for sporulation (By similarity) D2M30_17310 ENOG4105CHW UPF0052 protein D2M30_17315 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D2M30_17320 ENOG4108Z4K mutator MutT protein D2M30_17325 ENOG4105C3M thioredoxin reductase D2M30_17340 ENOG4105BZU Histidine kinase D2M30_17345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D2M30_17350 ENOG4105BZ1 (ABC) transporter D2M30_17355 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D2M30_17360 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D2M30_17365 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D2M30_17370 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D2M30_17375 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D2M30_17380 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D2M30_17385 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D2M30_17390 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) D2M30_17400 ENOG4108S4C acetyltransferase D2M30_17405 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D2M30_17415 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D2M30_17420 ENOG4105CE4 GlcNAc 6-P deacetylase D2M30_17425 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D2M30_17430 ENOG4105FDP GntR family transcriptional regulator D2M30_17435 ENOG4105J7D transcriptional regulator D2M30_17440 ENOG41088CQ domain protein D2M30_17445 ENOG41086DT Membrane protein of unknown function D2M30_17450 ENOG41067S9 phage shock protein C, PspC D2M30_17455 ENOG4108PY7 D2M30_17470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D2M30_17475 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D2M30_17490 ENOG4105MKU Transcriptional regulator D2M30_17515 ENOG4105CN1 protease D2M30_17520 ENOG4108M26 parallel beta-helix repeat protein D2M30_17525 ENOG4105CRP Part of the ABC transporter FtsEX involved in D2M30_17530 ENOG4105CAK Cell division ATP-binding protein ftsE D2M30_17550 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D2M30_17555 ENOG4105MS2 ribosomal subunit Interface protein D2M30_17570 ENOG4105MQ3 flagellar protein FliS D2M30_17575 ENOG4107RT6 flagellar hook-associated D2M30_17580 ENOG4105I03 Flagellin D2M30_17585 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D2M30_17590 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) D2M30_17600 ENOG4105DTJ flagellar hook-associated protein D2M30_17605 ENOG4105E1Q flagellar hook-associated protein D2M30_17620 ENOG4105RU3 D2M30_17625 ENOG41081UC Inherit from COG: Competence protein D2M30_17645 ENOG4105WH1 Two component transcriptional regulator luxr family D2M30_17650 ENOG4105BZU Histidine kinase D2M30_17655 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D2M30_17660 ENOG4108KGH TRANSCRIPTIONal D2M30_17665 ENOG4105ESV Glycosyl transferase, family 4 D2M30_17670 ENOG4107EF8 Glycosyl transferase (Group 1 D2M30_17685 ENOG4105QZI O-Antigen Polymerase D2M30_17690 ENOG4105C6Y Udp-glucose 6-dehydrogenase D2M30_17695 ENOG4107RA4 Glycosyl transferase (Group 1 D2M30_17700 ENOG4105PSV Polysaccharide Biosynthesis Protein D2M30_17705 ENOG4105D3Q Sugar transferase D2M30_17710 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D2M30_17715 ENOG4105JFG SpoIID LytB domain protein D2M30_17730 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D2M30_17735 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D2M30_17740 ENOG4105EY8 ABC transporter D2M30_17750 ENOG4107SJB teichoic acid biosynthesis D2M30_17755 ENOG41088M2 Glycosyl transferase family 2 D2M30_17760 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase D2M30_17770 ENOG4107RZX Teichoic acid biosynthesis protein D2M30_17780 ENOG4105DG6 mannose-6-phosphate isomerase D2M30_17795 ENOG4108NHD germination protein D2M30_17800 ENOG4108SHN Glycosyl transferase, family 2 D2M30_17805 ENOG4105C54 Major Facilitator superfamily D2M30_17810 ENOG4108KGH TRANSCRIPTIONal D2M30_17815 ENOG4105J7I hydrolase D2M30_17820 ENOG4106UBQ D2M30_17825 ENOG4105K4H Nlp p60 protein D2M30_17840 ENOG4105PNM synthesis protein D2M30_17850 ENOG4105N98 Capsule biosynthesis protein capB D2M30_17875 ENOG4105ETE Transcriptional regulator (LacI family D2M30_17880 ENOG4108RVA ribokinase D2M30_17885 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) D2M30_17890 ENOG4105C2J ABC transporter D2M30_17895 ENOG4105CNN ABC, transporter D2M30_17900 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D2M30_17910 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D2M30_17915 ENOG4107FQX Alpha-acetolactate decarboxylase D2M30_17925 ENOG4107RSM transcriptional regulator D2M30_17940 ENOG4106UIA D2M30_17955 ENOG4107XC4 flavin reductase domain protein, FMN-binding D2M30_17965 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D2M30_17975 ENOG4105CAH Chromate D2M30_17980 ENOG4105FGV Chromate D2M30_17985 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) D2M30_18010 ENOG4108XI2 Domain of unknown function (DUF1963) D2M30_18015 ENOG4105C6Y Udp-glucose 6-dehydrogenase D2M30_18020 ENOG4108RB3 Capsular polysaccharide biosynthesis protein D2M30_18025 ENOG4107YJ4 chain length determinant protein D2M30_18030 ENOG4105HTX biosynthesis protein D2M30_18045 ENOG4105KBK Zinc finger, swim domain protein D2M30_18050 ENOG4105C0D helicase D2M30_18055 ENOG410667J hydrolase D2M30_18060 ENOG4105E98 transcriptional regulator DeoR family D2M30_18065 ENOG4105Z8H single-stranded DNA-binding protein D2M30_18080 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D2M30_18085 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D2M30_18095 ENOG4105CGA flagellar basal-body rod protein FlgG D2M30_18105 ENOG4105DFF Rod shape-determining protein mreb D2M30_18115 ENOG4107MII Sugar-specific transcriptional regulator TrmB D2M30_18120 ENOG4105CZM Major Facilitator D2M30_18125 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease D2M30_18130 ENOG41080V3 Major Facilitator superfamily D2M30_18135 ENOG4105D3W isochorismatase D2M30_18140 ENOG4105BZU Histidine kinase D2M30_18150 ENOG4105CNI cell division protein FtsW D2M30_18155 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D2M30_18175 ENOG4105FRN stage II sporulation protein D2M30_18180 ENOG4107TCE N-acetyltransferase D2M30_18195 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D2M30_18200 ENOG4106BRK D2M30_18205 ENOG4108RYK Nad-dependent epimerase dehydratase D2M30_18210 ENOG4108Z40 Transcriptional regulator D2M30_18215 ENOG4105CQM Urea amidohydrolase subunit alpha D2M30_18220 ENOG4105KI2 Urea amidohydrolase subunit beta D2M30_18225 ENOG4108YZ9 Urea amidohydrolase subunit gamma D2M30_18245 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D2M30_18250 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D2M30_18255 ENOG4108TF4 von Willebrand factor, type A D2M30_18270 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D2M30_18280 ENOG4106778 Protein of unknown function (DUF1146) D2M30_18290 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D2M30_18295 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D2M30_18300 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D2M30_18305 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D2M30_18310 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D2M30_18325 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) D2M30_18335 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D2M30_18340 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D2M30_18345 ENOG4108UIC UPF0340 protein D2M30_18350 ENOG4108YZG isomerase D2M30_18355 ENOG4107WAU Protein tyrosine phosphatase D2M30_18360 ENOG410815N Probably functions as a manganese efflux pump (By similarity) D2M30_18365 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D2M30_18375 ENOG4108ZXQ stage ii sporulation protein r D2M30_18390 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D2M30_18395 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D2M30_18400 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D2M30_18410 ENOG4107TT2 Auxin Efflux Carrier D2M30_18415 ENOG4105C6K Malic enzyme D2M30_18420 ENOG4107104 thymidine kinase D2M30_18425 ENOG41082DI 50s ribosomal protein l31 D2M30_18430 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D2M30_18435 ENOG4105CBT Fructose-1,6-bisphosphatase D2M30_18440 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D2M30_18450 ENOG4105D2N Aldolase D2M30_18455 ENOG410812K response regulator receiver protein D2M30_18465 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D2M30_18475 ENOG4105DF6 Fe-S oxidoreductase D2M30_18485 ENOG4105E5J UV damage endonuclease D2M30_18495 ENOG4105BZ1 (ABC) transporter D2M30_18510 ENOG4105R3A Nitrate reductase D2M30_18515 ENOG4108IUE nitrate reductase beta subunit D2M30_18535 ENOG4107V6Q Cyclic nucleotide-binding domain D2M30_18545 ENOG4105C75 arginyL-tRNA synthetase D2M30_18550 ENOG410684U Domain of unknown function (DUF1934) D2M30_18570 ENOG4107JM4 Tetratricopeptide repeat D2M30_18580 ENOG4105CYW agmatinase D2M30_18585 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D2M30_18590 ENOG4105BZ4 penicillin-binding protein D2M30_18600 ENOG4108XFG YwhD family D2M30_18605 ENOG4108Z4T Peptidase M50 D2M30_18610 ENOG41069HH 4-oxalocrotonate tautomerase D2M30_18615 ENOG41067TZ transcriptional regulator, MarR family D2M30_18625 ENOG4105CUB amino acid D2M30_18635 ENOG4105DCI Phosphohydrolase D2M30_18645 ENOG4108VCI transcription factor, rsfa family D2M30_18650 ENOG4105K7K Transcriptional regulator D2M30_18660 ENOG4105CJ1 ABC, transporter D2M30_18665 ENOG4108TU7 Inherit from COG: (ABC) transporter D2M30_18690 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) D2M30_18695 ENOG4105DUM transcriptional regulator, lysR family D2M30_18700 ENOG4105HMI Membrane D2M30_18705 ENOG4108IJ2 phosphate acetyltransferase D2M30_18710 ENOG4107JTW chlorite dismutase D2M30_18720 ENOG4105CHM Aminotransferase D2M30_18730 ENOG4108M32 ATP-grasp domain D2M30_18745 ENOG41061WN bacilysin biosynthesis protein D2M30_18750 ENOG4105FCW Major Facilitator superfamily D2M30_18755 ENOG4105C2C drug resistance transporter, Bcr CflA D2M30_18775 ENOG4105D82 Glutamate dehydrogenase D2M30_18785 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase D2M30_18790 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase D2M30_18795 ENOG4105C1B dTDP-glucose 4-6-dehydratase D2M30_18800 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D2M30_18805 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG D2M30_18810 ENOG4107TY6 Acylneuraminate cytidylyltransferase D2M30_18820 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD D2M30_18825 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D2M30_18860 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D2M30_18865 ENOG4108RJ9 Glycosyl transferase, family 2 D2M30_18875 ENOG4105DWF phosphomethylpyrimidine kinase D2M30_18890 ENOG4105C5Y PTS System D2M30_18905 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin D2M30_18910 ENOG4105DEN Luciferase family D2M30_18915 ENOG4105D29 Helix-turn-helix type 11 domain protein D2M30_18920 ENOG4105CHR reductase D2M30_18935 ENOG4108DBC nitroreductase D2M30_18945 ENOG4105I4A GCN5-related N-acetyltransferase D2M30_18965 ENOG4105BZ9 Cytochrome C oxidase, subunit I D2M30_18970 ENOG4105E2S oxidase) subunit II D2M30_18975 ENOG4107BMA Transglycosylase associated protein D2M30_18985 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D2M30_18990 ENOG4105WH5 Teichoic acid glycosylation protein D2M30_19015 ENOG4107ZXU DSBA oxidoreductase D2M30_19020 ENOG4105DBE peroxidase D2M30_19025 ENOG410650H (LipO)protein D2M30_19030 ENOG4107SJW iron permease, FTR1 D2M30_19035 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D2M30_19040 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase D2M30_19045 ENOG4105CMU LysR family (Transcriptional regulator D2M30_19050 ENOG4105VAW lrga family D2M30_19055 ENOG41067MG lrgb family D2M30_19065 ENOG4107TXC Transcriptional regulator D2M30_19085 ENOG4105DR4 Methyltransferase D2M30_19095 ENOG4105CK1 PTS System D2M30_19100 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin D2M30_19105 ENOG4105X1N Glycosyl transferase family 8 D2M30_19115 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D2M30_19130 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) D2M30_19135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D2M30_19140 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) D2M30_19145 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD D2M30_19150 ENOG4105CM2 brancheD-chain amino acid aminotransferase D2M30_19155 ENOG4105F8D glycoside hydrolase family 4 D2M30_19160 ENOG4105VCP PTS System D2M30_19165 ENOG4105CK1 PTS System D2M30_19170 ENOG4105VZJ PTS System D2M30_19175 ENOG4105EMD TRANSCRIPTIONal D2M30_19190 ENOG4105DQ5 transport system permease protein D2M30_19195 ENOG4105EHG Permease protein D2M30_19205 ENOG41082YX Transcriptional regulator, arsr family D2M30_19210 ENOG4107R5R arsenical pump membrane protein D2M30_19215 ENOG4105VZJ PTS System D2M30_19220 ENOG4105VCP PTS System D2M30_19225 ENOG4105CK1 PTS System D2M30_19230 ENOG4105CS2 ec 3.2.1.21 D2M30_19235 ENOG4105EVU fructokinase D2M30_19240 ENOG4105DG6 mannose-6-phosphate isomerase D2M30_19250 ENOG4105CH6 catalase D2M30_19255 ENOG4107QHE Choloylglycine hydrolase D2M30_19260 ENOG4105ETS cytosine purines uracil thiamine allantoin D2M30_19265 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D2M30_19270 ENOG4108JJ8 (ABC) transporter D2M30_19275 ENOG4108JJ9 ABC, transporter D2M30_19280 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D2M30_19285 ENOG4105C4M (Ubiquinol oxidase) subunit I D2M30_19290 ENOG4105D2K citrate carrier protein D2M30_19295 ENOG4107BJW polysaccharide deacetylase D2M30_19310 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) D2M30_19320 ENOG4105CMR udp-glucose 4-epimerase D2M30_19340 ENOG4105DHI Methyltransferase D2M30_19360 ENOG4105CH6 catalase D2M30_19365 ENOG4105D4T Citrate transporter D2M30_19375 ENOG4105CID antiterminator D2M30_19380 ENOG4105DEU major facilitator superfamily D2M30_19385 ENOG4105C1J atp-dependent rna helicase D2M30_19470 ENOG4105CNA YD repeat protein D2M30_19475 ENOG4108NR7 pectate lyase D2M30_19485 ENOG4107YZX Universal stress protein D2M30_19490 ENOG4105CS2 ec 3.2.1.21 D2M30_19495 ENOG4105C5Y PTS System D2M30_19505 ENOG4105M6F mutator MutT protein D2M30_19510 ENOG4106Z5D Glycoside Hydrolase Family 43 D2M30_19525 ENOG4105C84 Histidine ammonia-lyase D2M30_19530 ENOG4105CGP Urocanate hydratase D2M30_19535 ENOG4105CI2 imidazolone-5-propionate hydrolase D2M30_19540 ENOG4107W25 arginase agmatinase formiminoglutamase D2M30_19550 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D2M30_19555 ENOG4105D9N nucleoside D2M30_19560 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D2M30_19565 ENOG4107RHR regulatoR D2M30_19570 ENOG410667J hydrolase D2M30_19600 ENOG4108V5C ABC transporter D2M30_19635 ENOG4105WZ4 isomerase D2M30_19640 ENOG4105F0H myo-inositol catabolism protein D2M30_19645 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D2M30_19655 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) D2M30_19665 ENOG4105EDK PfkB domain protein D2M30_19675 ENOG4105C26 Dehydrogenase D2M30_19685 ENOG4105CPC Aldo Keto reductase D2M30_19690 ENOG4107QNK )-transporter D2M30_19695 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D2M30_19700 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D2M30_19705 ENOG4108S01 response regulator D2M30_19710 ENOG4108ZGX Histidine kinase D2M30_19715 ENOG4105ECK Fatty Acid Desaturase D2M30_19720 ENOG4105ST3 Transcriptional regulator D2M30_19725 ENOG4105C26 Dehydrogenase D2M30_19730 ENOG4108ITS PQQ enzyme repeat D2M30_19740 ENOG4105WAB arsR family transcriptional regulator D2M30_19745 ENOG4105F27 Major Facilitator D2M30_19750 ENOG41085PJ rdd domain containing protein D2M30_19760 ENOG4105D3R alkyl hydroperoxide reductase D2M30_19765 ENOG4108JU3 Alkyl hydroperoxide reductase D2M30_19775 ENOG4105C85 amino acid D2M30_19795 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 D2M30_19800 ENOG4108XHQ (2Fe-2S)-binding domain protein D2M30_19820 ENOG4105XRQ Xanthine dehydrogenase accessory factor D2M30_19850 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D2M30_19870 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) D2M30_19875 ENOG4105CPC Aldo Keto reductase D2M30_19880 ENOG4105WQG acetyltransferase D2M30_19890 ENOG41066UZ arginase EC 3.5.3.1 D2M30_19895 ENOG4108IQI permease D2M30_19900 ENOG4105C8Y Acetylornithine aminotransferase D2M30_19910 ENOG41082BM Transcriptional regulator, arsr family D2M30_19915 ENOG4108JUB Transcriptional regulator D2M30_19925 ENOG4105C5H ABC transporter D2M30_19940 ENOG4105D06 uba thif-type nad fad binding protein D2M30_19945 ENOG41062D9 Histidine kinase D2M30_19950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D2M30_19960 ENOG4105C0H protease D2M30_19965 ENOG4105Q2H domain protein D2M30_19980 ENOG4105BZU Histidine kinase D2M30_19985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D2M30_20015 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D2M30_20020 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase D2M30_20025 ENOG4105CDU Replicative dna helicase D2M30_20065 ENOG4105CPK Glycosyl transferase (Group 1 D2M30_20085 ENOG4105BZR domain protein D2M30_20090 ENOG4108XMW Membrane D2M30_20105 ENOG4105KVH Transcriptional regulator D2M30_20110 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase D2M30_20115 ENOG4108UZ3 Transporter D2M30_20120 ENOG4105EDQ levansucrase EC 2.4.1.10 D2M30_20125 ENOG4108HKT sucrose-6-phosphate hydrolase D2M30_20130 ENOG4107XBN GntR Family Transcriptional Regulator D2M30_20155 ENOG4108TVJ Nitroreductase D2M30_20160 ENOG4105FS7 Transcriptional regulator D2M30_20170 ENOG4108U05 Transcriptional regulator D2M30_20175 ENOG41082BV acetyltransferase D2M30_20180 ENOG41085FC arsR family transcriptional regulator D2M30_20185 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D2M30_20190 ENOG4105C7Z Conserved Protein D2M30_20195 ENOG4105DXI Major Facilitator superfamily D2M30_20240 ENOG4105K4H Nlp p60 protein D2M30_20250 ENOG4105P1M Domain of unknown function (DUF1874) D2M30_20305 ENOG4106128 DNA-binding helix-turn-helix protein D2M30_20310 ENOG4106BHR ftsk SpoIIIE family protein D2M30_20315 ENOG4108RYM conjugative transposon protein D2M30_20335 ENOG4108IMY Transcriptional regulator D2M30_20340 ENOG41068WC Domain of unknown function (DUF955) D2M30_20355 ENOG4105C7Z Conserved Protein D2M30_20360 ENOG4105C7Z Conserved Protein D2M30_20365 ENOG4107FCW Abortive infection protein D2M30_20375 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase D2M30_20385 ENOG4105CGK Exodeoxyribonuclease III D2M30_20390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D2M30_20400 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D2M30_20405 ENOG4108UUM single-stranded DNA-binding protein D2M30_20410 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D2M30_20415 ENOG4105C3G gtp-binding protein D2M30_20420 ENOG4108J2R molybdopterin oxidoreductase D2M30_20425 ENOG4105VDK protein, conserved in bacteria D2M30_20440 ENOG4108ZDA Sporulation protein YyaC D2M30_20445 ENOG4105FA0 parb-like partition protein D2M30_20450 ENOG4107QJE Chromosome Partitioning Protein D2M30_20465 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D2M30_20470 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D2M30_20485 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)