locus-tag	class	description
D2M30_00010	COG0592	DNA-directed DNA polymerase activity
D2M30_00015	COG2501	S4 domain
D2M30_00030	COG0187	DNA topoisomerase II activity
D2M30_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2M30_00070	COG0516	GMP reductase activity
D2M30_00070	COG0517	IMP dehydrogenase activity
D2M30_00075	COG1686	Belongs to the peptidase S11 family
D2M30_00095	COG1929	Belongs to the glycerate kinase type-1 family
D2M30_00105	COG1428	Deoxynucleoside kinase
D2M30_00110	COG1428	Deoxynucleoside kinase
D2M30_00115	COG1388	LysM domain
D2M30_00115	COG3858	chitin binding
D2M30_00120	COG1335	isochorismatase
D2M30_00125	COG0590	tRNA wobble adenosine to inosine editing
D2M30_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D2M30_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D2M30_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D2M30_00195	COG3853	Toxic anion resistance protein (TelA)
D2M30_00200	COG1982	Orn Lys Arg decarboxylase major
D2M30_00210	COG3870	Protein conserved in bacteria
D2M30_00215	COG1728	Protein conserved in bacteria
D2M30_00220	COG0470	DNA polymerase III
D2M30_00225	COG1774	PSP1 C-terminal conserved region
D2M30_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D2M30_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D2M30_00250	COG2002	toxin-antitoxin pair type II binding
D2M30_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2M30_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2M30_00260	COG0084	hydrolase, TatD family'
D2M30_00265	COG3583	domain protein
D2M30_00265	COG3584	3D domain protein
D2M30_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2M30_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D2M30_00285	COG4466	Protein conserved in bacteria
D2M30_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2M30_00305	COG0251	oxidation-reduction process
D2M30_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D2M30_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D2M30_00345	COG2002	toxin-antitoxin pair type II binding
D2M30_00350	COG2244	polysaccharide biosynthetic process
D2M30_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D2M30_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D2M30_00380	COG1098	S1 RNA binding domain
D2M30_00395	COG2208	phosphoserine phosphatase activity
D2M30_00400	COG2304	oxidoreductase activity
D2M30_00405	COG0515	serine threonine protein kinase
D2M30_00410	COG0037	tRNA processing
D2M30_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2M30_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2M30_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2M30_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
D2M30_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2M30_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D2M30_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D2M30_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D2M30_00475	COG1396	sequence-specific DNA binding
D2M30_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D2M30_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D2M30_00570	COG4463	regulation of RNA biosynthetic process
D2M30_00575	COG3880	PFAM UvrB UvrC protein
D2M30_00585	COG0542	response to heat
D2M30_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D2M30_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D2M30_00600	COG4956	integral membrane protein (PIN domain superfamily)
D2M30_00620	COG1045	serine acetyltransferase
D2M30_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D2M30_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2M30_00640	COG3688	RNA-binding protein containing a PIN domain
D2M30_00645	COG1595	DNA-templated transcription, initiation
D2M30_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2M30_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D2M30_00660	COG0250	Participates in transcription elongation, termination and antitermination
D2M30_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D2M30_00680	COG0222	ribosome binding
D2M30_00685	COG2813	Specifically methylates the guanine in position
D2M30_00700	COG1358	cellular component organization or biogenesis
D2M30_00725	COG0596	Alpha beta hydrolase
D2M30_00730	COG0051	transcription antitermination factor activity, RNA binding
D2M30_00745	COG0089	rRNA binding
D2M30_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D2M30_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D2M30_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D2M30_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
D2M30_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D2M30_00825	COG1841	ribosomal large subunit assembly
D2M30_00835	COG0201	protein transport
D2M30_00845	COG0024	Methionine aminopeptidase
D2M30_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D2M30_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D2M30_00885	COG1122	ATPase activity
D2M30_00890	COG1122	ATPase activity
D2M30_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2M30_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D2M30_00915	COG2226	methyltransferase
D2M30_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_00930	COG0489	protein tyrosine kinase activity
D2M30_00940	COG2194	sulfuric ester hydrolase activity
D2M30_00945	COG0726	polysaccharide deacetylase
D2M30_01005	COG0738	Major facilitator superfamily
D2M30_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D2M30_01025	COG0659	secondary active sulfate transmembrane transporter activity
D2M30_01030	COG0385	Bile acid
D2M30_01035	COG2819	hydrolase of the alpha beta superfamily
D2M30_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2M30_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2M30_01055	COG2207	Transcriptional regulator
D2M30_01060	COG3876	Protein conserved in bacteria
D2M30_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
D2M30_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2M30_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_01075	COG1263	PTS System
D2M30_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2M30_01090	COG1683	Conserved Protein
D2M30_01120	COG1595	DNA-templated transcription, initiation
D2M30_01125	COG5662	AntiSigma factor
D2M30_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D2M30_01135	COG4856	YbbR-like protein
D2M30_01175	COG1346	cytolysis
D2M30_01180	COG1380	Effector of murein hydrolase LrgA
D2M30_01185	COG1846	Transcriptional regulator
D2M30_01190	COG1113	amino acid transport
D2M30_01195	COG1011	Hydrolase
D2M30_01200	COG4585	Histidine kinase
D2M30_01205	COG2197	response regulator
D2M30_01210	COG1131	(ABC) transporter
D2M30_01220	COG0842	Transport permease protein
D2M30_01220	COG1511	domain protein
D2M30_01250	COG0531	amino acid
D2M30_01265	COG0584	glycerophosphoryl diester phosphodiesterase
D2M30_01270	COG2271	Major facilitator Superfamily
D2M30_01285	COG2368	4-hydroxyphenylacetate
D2M30_01295	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_01300	COG0697	spore germination
D2M30_01305	COG1917	Cupin 2, conserved barrel domain protein
D2M30_01305	COG2207	Transcriptional regulator
D2M30_01325	COG0371	Dehydrogenase
D2M30_01335	COG1183	phosphatidylcholine synthase activity
D2M30_01340	COG0586	Pfam SNARE associated Golgi protein
D2M30_01345	COG0688	phosphatidylethanolamine metabolic process
D2M30_01360	COG1301	dicarboxylic acid transport
D2M30_01365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2M30_01370	COG0833	amino acid
D2M30_01375	COG2040	homocysteine
D2M30_01380	COG1115	amino acid carrier protein
D2M30_01385	COG2066	Belongs to the glutaminase family
D2M30_01390	COG4191	Histidine kinase
D2M30_01395	COG0784	Response regulator, receiver
D2M30_01400	COG3173	Aminoglycoside phosphotransferase
D2M30_01410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2M30_01420	COG0346	lactoylglutathione lyase activity
D2M30_01425	COG2259	Doxx family
D2M30_01430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_01450	COG3773	Cell wall hydrolase
D2M30_01455	COG3540	Alkaline phosphatase
D2M30_01460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2M30_01465	COG0805	protein transport
D2M30_01470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D2M30_01475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2M30_01480	COG0477	Major facilitator Superfamily
D2M30_01485	COG1309	transcriptional regulator
D2M30_01490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D2M30_01495	COG1405	negative regulation of cell septum assembly
D2M30_01495	COG3012	SEC-C Motif Domain Protein
D2M30_01500	COG0667	Aldo Keto reductase
D2M30_01510	COG1595	DNA-templated transcription, initiation
D2M30_01515	COG1595	DNA-templated transcription, initiation
D2M30_01520	COG1876	peptidase activity
D2M30_01525	COG0457	Tetratricopeptide repeat
D2M30_01530	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_01535	COG0366	Alpha amylase catalytic
D2M30_01540	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2M30_01545	COG1121	(ABC) transporter
D2M30_01550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2M30_01555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2M30_01560	COG2310	stress, protein
D2M30_01565	COG2310	stress, protein
D2M30_01570	COG2310	stress, protein
D2M30_01575	COG0861	Integral membrane protein TerC family
D2M30_01585	COG3853	Toxic anion resistance protein (TelA)
D2M30_01590	COG0477	Major facilitator Superfamily
D2M30_01595	COG4175	Glycine betaine
D2M30_01595	COG0517	IMP dehydrogenase activity
D2M30_01600	COG4176	ABC-type proline glycine betaine transport system permease component
D2M30_01605	COG2113	Glycine betaine
D2M30_01610	COG1473	amidohydrolase
D2M30_01615	COG1288	antiporter activity
D2M30_01625	COG1714	RDD family
D2M30_01635	COG2814	Major facilitator Superfamily
D2M30_01640	COG1846	Transcriptional regulator
D2M30_01645	COG1280	lysine exporter protein (LysE YggA)
D2M30_01650	COG3403	YqcI/YcgG family
D2M30_01655	COG1113	amino acid transport
D2M30_01660	COG3665	Urea carboxylase-associated protein
D2M30_01670	COG1082	Xylose isomerase domain protein TIM barrel
D2M30_01675	COG2271	Major facilitator Superfamily
D2M30_01680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D2M30_01685	COG3458	cephalosporin-C deacetylase activity
D2M30_01690	COG3541	Predicted nucleotidyltransferase
D2M30_01695	COG0506	proline dehydrogenase activity
D2M30_01700	COG1012	belongs to the aldehyde dehydrogenase family
D2M30_01705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2M30_01710	COG2508	Transcriptional regulator
D2M30_01720	COG1587	Uroporphyrinogen-III synthase
D2M30_01720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2M30_01725	COG2146	nitrite reductase [NAD(P)H] activity
D2M30_01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2M30_01735	COG2223	nitrite transmembrane transporter activity
D2M30_01740	COG0523	cobalamin synthesis protein
D2M30_01745	COG1063	alcohol dehydrogenase
D2M30_01750	COG1714	RDD family
D2M30_01760	COG2723	6-phospho-beta-galactosidase activity
D2M30_01770	COG3209	COG3209 Rhs family protein
D2M30_01780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D2M30_01785	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D2M30_01790	COG1733	regulation of RNA biosynthetic process
D2M30_01800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_01805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_01810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_01815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D2M30_01830	COG2364	Membrane
D2M30_01835	COG1126	abc transporter atp-binding protein
D2M30_01840	COG0765	amino acid transport
D2M30_01845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_01850	COG0583	DNA-binding transcription factor activity
D2M30_01855	COG0163	prenyltransferase activity
D2M30_01860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D2M30_01875	COG3104	oligopeptide transport
D2M30_01880	COG5434	Belongs to the glycosyl hydrolase 28 family
D2M30_01890	COG0697	spore germination
D2M30_01900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D2M30_01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_01920	COG0765	amino acid transport
D2M30_01925	COG1126	abc transporter atp-binding protein
D2M30_01935	COG2079	MmgE PrpD family protein
D2M30_01940	COG1136	(ABC) transporter
D2M30_01945	COG0577	efflux transmembrane transporter activity
D2M30_01950	COG0745	RESPONSE REGULATOR receiver
D2M30_01955	COG3850	Histidine kinase
D2M30_01955	COG5002	protein histidine kinase activity
D2M30_01960	COG0457	Tetratricopeptide repeat
D2M30_01975	COG0527	aspartate kinase activity
D2M30_01980	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_01985	COG4605	iron ion homeostasis
D2M30_01990	COG4604	ABC transporter, ATP-binding protein
D2M30_01995	COG4607	ABC-type enterochelin transport system periplasmic component
D2M30_02000	COG2814	Major facilitator Superfamily
D2M30_02005	COG1309	transcriptional regulator
D2M30_02010	COG0778	Nitroreductase
D2M30_02015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2M30_02020	COG0640	Transcriptional regulator
D2M30_02025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2M30_02030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D2M30_02035	COG1012	belongs to the aldehyde dehydrogenase family
D2M30_02040	COG4975	Glucose uptake
D2M30_02045	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_02050	COG4549	nuclear export factor GLE1
D2M30_02055	COG2372	response to copper ion
D2M30_02055	COG1276	copper resistance
D2M30_02060	COG1349	DNA-binding transcription factor activity
D2M30_02070	COG2213	PTS system mannitol-specific
D2M30_02075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_02085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D2M30_02095	COG0561	phosphatase activity
D2M30_02105	COG1914	H( )-stimulated, divalent metal cation uptake system
D2M30_02115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D2M30_02120	COG1984	allophanate hydrolase subunit 2
D2M30_02125	COG1414	Transcriptional regulator
D2M30_02130	COG2755	lipolytic protein G-D-S-L family
D2M30_02140	COG2329	Antibiotic biosynthesis monooxygenase
D2M30_02145	COG0768	penicillin binding
D2M30_02150	COG4989	oxidoreductase activity
D2M30_02155	COG3711	transcriptional antiterminator
D2M30_02160	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_02165	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_02170	COG1917	Cupin 2, conserved barrel domain protein
D2M30_02175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2M30_02180	COG3871	stress protein (general stress protein 26)
D2M30_02190	COG2814	Major facilitator Superfamily
D2M30_02195	COG1522	sequence-specific DNA binding
D2M30_02200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2M30_02200	COG0551	DNA topoisomerase type I activity
D2M30_02205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D2M30_02210	COG3706	GGDEF domain
D2M30_02215	COG5298	Protein conserved in bacteria
D2M30_02220	COG1215	transferase activity, transferring glycosyl groups
D2M30_02230	COG0531	amino acid
D2M30_02235	COG0028	Belongs to the TPP enzyme family
D2M30_02255	COG1914	H( )-stimulated, divalent metal cation uptake system
D2M30_02265	COG4876	unkown
D2M30_02275	COG2076	Multidrug Resistance protein
D2M30_02280	COG2217	Heavy metal translocating P-type atpase
D2M30_02285	COG3729	General stress protein
D2M30_02290	COG0662	Cupin 2, conserved barrel domain protein
D2M30_02295	COG2329	Antibiotic biosynthesis monooxygenase
D2M30_02300	COG3546	catalase activity
D2M30_02305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D2M30_02310	COG3290	protein histidine kinase activity
D2M30_02315	COG4565	transcriptional regulatory protein
D2M30_02320	COG1301	dicarboxylic acid transport
D2M30_02325	COG0628	permease
D2M30_02330	COG1131	(ABC) transporter
D2M30_02335	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2M30_02345	COG1960	acyl-CoA dehydrogenase activity
D2M30_02365	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2M30_02370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_02380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D2M30_02385	COG0513	Belongs to the DEAD box helicase family
D2M30_02390	COG3402	PFAM membrane-flanked domain
D2M30_02395	COG3428	Bacterial PH domain
D2M30_02400	COG0705	Rhomboid family
D2M30_02415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2M30_02420	COG0864	Transcriptional regulator
D2M30_02425	COG2337	Toxic component of a toxin-antitoxin (TA) module
D2M30_02430	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_02435	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_02440	COG2172	sigma factor antagonist activity
D2M30_02445	COG2208	phosphoserine phosphatase activity
D2M30_02450	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_02460	COG1191	sigma factor activity
D2M30_02465	COG2208	phosphoserine phosphatase activity
D2M30_02470	COG2183	response to ionizing radiation
D2M30_02525	COG4124	Belongs to the glycosyl hydrolase 26 family
D2M30_02530	COG1846	Transcriptional regulator
D2M30_02535	COG0456	acetyltransferase
D2M30_02540	COG2808	Putative FMN-binding domain
D2M30_02560	COG0457	Tetratricopeptide repeat
D2M30_02585	COG1764	response to oxidative stress
D2M30_02590	COG1846	Transcriptional regulator
D2M30_02595	COG1846	Transcriptional regulator
D2M30_02595	COG0456	acetyltransferase
D2M30_02600	COG2271	Major facilitator Superfamily
D2M30_02605	COG4124	Belongs to the glycosyl hydrolase 26 family
D2M30_02625	COG1959	2 iron, 2 sulfur cluster binding
D2M30_02640	COG1278	Cold shock
D2M30_02645	COG1794	racemase activity, acting on amino acids and derivatives
D2M30_02665	COG0477	Major facilitator Superfamily
D2M30_02670	COG3621	Patatin-like phospholipase
D2M30_02680	COG0277	FAD linked oxidase domain protein
D2M30_02700	COG0662	Cupin 2, conserved barrel domain protein
D2M30_02710	COG0456	acetyltransferase
D2M30_02715	COG2207	Transcriptional regulator
D2M30_02715	COG3708	Transcriptional regulator
D2M30_02735	COG1064	alcohol dehydrogenase
D2M30_02740	COG0789	Transcriptional regulator
D2M30_02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2M30_02755	COG2808	Putative FMN-binding domain
D2M30_02765	COG2814	Major facilitator Superfamily
D2M30_02770	COG1309	transcriptional regulator
D2M30_02775	COG0697	spore germination
D2M30_02780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2M30_02785	COG5577	PFAM Coat F domain
D2M30_02795	COG1063	alcohol dehydrogenase
D2M30_02800	COG5577	PFAM Coat F domain
D2M30_02810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D2M30_02820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2M30_02825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_02835	COG2814	Major facilitator Superfamily
D2M30_02840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2M30_02850	COG0730	response to heat
D2M30_02855	COG0456	acetyltransferase
D2M30_02860	COG0789	Transcriptional regulator
D2M30_02860	COG4978	Transcriptional regulator
D2M30_02865	COG0697	spore germination
D2M30_02870	COG1051	belongs to the nudix hydrolase family
D2M30_02875	COG0596	Alpha beta hydrolase
D2M30_02880	COG0473	3-isopropylmalate dehydrogenase activity
D2M30_02885	COG1802	Transcriptional regulator
D2M30_02890	COG1819	glycosyl
D2M30_02900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2M30_02905	COG1388	LysM domain
D2M30_02910	COG2814	Major facilitator Superfamily
D2M30_02915	COG2188	Transcriptional regulator
D2M30_02920	COG2186	Transcriptional regulator
D2M30_02925	COG2807	transmembrane transport
D2M30_02930	COG2076	Multidrug Resistance protein
D2M30_02935	COG2076	Multidrug Resistance protein
D2M30_02940	COG1309	transcriptional regulator
D2M30_02945	COG0531	amino acid
D2M30_02955	COG3832	glyoxalase III activity
D2M30_02960	COG0604	alcohol dehydrogenase
D2M30_02965	COG2814	Major facilitator Superfamily
D2M30_03005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D2M30_03010	COG0802	atpase or kinase
D2M30_03015	COG1214	PFAM Peptidase M22, glycoprotease
D2M30_03020	COG0456	acetyltransferase
D2M30_03025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D2M30_03030	COG0488	(ABC) transporter
D2M30_03045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2M30_03050	COG0805	protein transport
D2M30_03060	COG1266	CAAX protease self-immunity
D2M30_03065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D2M30_03080	COG5444	nuclease activity
D2M30_03105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D2M30_03110	COG0457	Tetratricopeptide repeat
D2M30_03115	COG1063	alcohol dehydrogenase
D2M30_03120	COG2211	Major facilitator Superfamily
D2M30_03125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2M30_03135	COG1842	Phage shock protein A
D2M30_03140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2M30_03145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D2M30_03150	COG4260	virion core protein, lumpy skin disease virus
D2M30_03155	COG2755	lipolytic protein G-D-S-L family
D2M30_03155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D2M30_03165	COG1595	DNA-templated transcription, initiation
D2M30_03170	COG1063	alcohol dehydrogenase
D2M30_03175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D2M30_03180	COG0823	Involved in the tonB-independent uptake of proteins
D2M30_03190	COG2132	Multicopper oxidase
D2M30_03195	COG1113	amino acid transport
D2M30_03205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2M30_03210	COG0714	Associated with various cellular activities
D2M30_03215	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D2M30_03220	COG1305	Transglutaminase-like
D2M30_03240	COG2252	PERMEase
D2M30_03245	COG3064	Membrane
D2M30_03265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D2M30_03270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D2M30_03275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D2M30_03280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D2M30_03285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2M30_03300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D2M30_03310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D2M30_03315	COG0138	bifunctional purine biosynthesis protein purh
D2M30_03320	COG0151	Belongs to the GarS family
D2M30_03325	COG1522	sequence-specific DNA binding
D2M30_03330	COG0531	amino acid
D2M30_03340	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D2M30_03345	COG1470	cell adhesion involved in biofilm formation
D2M30_03350	COG4496	protein, YerC YecD
D2M30_03355	COG0069	glutamate synthase activity
D2M30_03365	COG0210	DNA helicase
D2M30_03375	COG4851	CamS sex pheromone cAM373 precursor
D2M30_03380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2M30_03385	COG1285	pathogenesis
D2M30_03390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2M30_03410	COG1309	transcriptional regulator
D2M30_03415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D2M30_03420	COG1597	lipid kinase activity
D2M30_03425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2M30_03430	COG2197	response regulator
D2M30_03440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_03450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2M30_03460	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_03465	COG1131	(ABC) transporter
D2M30_03495	COG5444	nuclease activity
D2M30_03515	COG5444	nuclease activity
D2M30_03545	COG3546	catalase activity
D2M30_03550	COG0454	-acetyltransferase
D2M30_03560	COG2323	membrane
D2M30_03565	COG2329	Antibiotic biosynthesis monooxygenase
D2M30_03570	COG0346	lactoylglutathione lyase activity
D2M30_03575	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_03580	COG5583	Uncharacterized small protein (DUF2292)
D2M30_03585	COG0196	riboflavin kinase activity
D2M30_03590	COG0670	Belongs to the BI1 family
D2M30_03600	COG1846	Transcriptional regulator
D2M30_03605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D2M30_03615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2M30_03615	COG2124	cytochrome p450
D2M30_03625	COG1368	sulfuric ester hydrolase activity
D2M30_03630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D2M30_03635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2M30_03640	COG1442	glycosyl transferase family 8
D2M30_03645	COG1216	Glycosyl transferase, family 2
D2M30_03650	COG1442	glycosyl transferase family 8
D2M30_03655	COG2223	nitrite transmembrane transporter activity
D2M30_03660	COG0531	amino acid
D2M30_03665	COG1012	belongs to the aldehyde dehydrogenase family
D2M30_03670	COG0840	transmembrane signaling receptor activity
D2M30_03675	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_03680	COG0457	Tetratricopeptide repeat
D2M30_03680	COG0463	Glycosyl transferase, family 2
D2M30_03685	COG0488	(ABC) transporter
D2M30_03690	COG0789	Transcriptional regulator
D2M30_03695	COG2814	Major facilitator Superfamily
D2M30_03700	COG0488	(ABC) transporter
D2M30_03705	COG0513	Belongs to the DEAD box helicase family
D2M30_03710	COG2130	NADP-dependent
D2M30_03725	COG3866	Pectate lyase
D2M30_03730	COG0471	metal ion transport
D2M30_03755	COG3290	protein histidine kinase activity
D2M30_03760	COG4565	transcriptional regulatory protein
D2M30_03765	COG3181	Tripartite tricarboxylate transporter family receptor
D2M30_03770	COG2851	Citrate transporter
D2M30_03775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_03780	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D2M30_03790	COG2258	MOSC domain
D2M30_03805	COG0024	Methionine aminopeptidase
D2M30_03810	COG1263	PTS System
D2M30_03810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_03820	COG1368	sulfuric ester hydrolase activity
D2M30_03830	COG0071	Belongs to the small heat shock protein (HSP20) family
D2M30_03845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_03845	COG1263	PTS System
D2M30_03850	COG0366	Alpha amylase catalytic
D2M30_03855	COG2188	Transcriptional regulator
D2M30_03860	COG0778	Nitroreductase
D2M30_03875	COG0737	Belongs to the 5'-nucleotidase family
D2M30_03880	COG0693	protein deglycase activity
D2M30_03890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D2M30_03900	COG2814	Major facilitator Superfamily
D2M30_03910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2M30_03915	COG4980	gas vesicle protein
D2M30_03920	COG1295	ribonuclease BN
D2M30_03925	COG0477	Major facilitator Superfamily
D2M30_03930	COG0387	Pfam Sodium calcium exchanger
D2M30_03940	COG0668	transmembrane transport
D2M30_03945	COG0535	radical SAM domain protein
D2M30_03955	COG0726	polysaccharide deacetylase
D2M30_03960	COG2084	Dehydrogenase
D2M30_03970	COG0598	Magnesium transport protein CorA
D2M30_03975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D2M30_03980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2M30_03995	COG1132	(ABC) transporter
D2M30_04000	COG0515	serine threonine protein kinase
D2M30_04010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D2M30_04015	COG4637	Psort location Cytoplasmic, score
D2M30_04020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2M30_04025	COG0022	dehydrogenase e1 component
D2M30_04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2M30_04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2M30_04040	COG3284	Transcriptional regulator
D2M30_04050	COG1486	melibiose metabolic process
D2M30_04055	COG1737	Transcriptional regulator
D2M30_04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_04060	COG1263	PTS System
D2M30_04065	COG5434	Belongs to the glycosyl hydrolase 28 family
D2M30_04070	COG1132	(ABC) transporter
D2M30_04075	COG1132	(ABC) transporter
D2M30_04080	COG2259	Doxx family
D2M30_04085	COG2514	catechol 2,3-dioxygenase activity
D2M30_04095	COG1695	Transcriptional regulator
D2M30_04100	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2M30_04105	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D2M30_04110	COG2732	(Barnase) inhibitor
D2M30_04115	COG2318	DinB family
D2M30_04120	COG2814	Major facilitator Superfamily
D2M30_04125	COG1846	Transcriptional regulator
D2M30_04130	COG0392	lysyltransferase activity
D2M30_04130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D2M30_04135	COG0384	phenazine biosynthesis protein PhzF
D2M30_04140	COG0778	Nitroreductase
D2M30_04155	COG1090	epimerase
D2M30_04170	COG2814	Major facilitator Superfamily
D2M30_04180	COG3591	Belongs to the peptidase S1B family
D2M30_04195	COG3103	Sh3 type 3 domain protein
D2M30_04200	COG5658	integral membrane protein
D2M30_04205	COG0596	Alpha beta hydrolase
D2M30_04210	COG0463	Glycosyl transferase, family 2
D2M30_04215	COG4485	Bacterial membrane protein, YfhO
D2M30_04220	COG1988	membrane-bound metal-dependent
D2M30_04225	COG1194	a g-specific adenine glycosylase
D2M30_04235	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_04255	COG1132	(ABC) transporter
D2M30_04260	COG4129	membrane
D2M30_04270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D2M30_04275	COG0735	belongs to the Fur family
D2M30_04385	COG1757	Na H antiporter
D2M30_04390	COG3340	Belongs to the peptidase S51 family
D2M30_04400	COG0277	FAD linked oxidase domain protein
D2M30_04410	COG0747	negative chemotaxis
D2M30_04415	COG0601	transmembrane transport
D2M30_04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2M30_04425	COG0444	Belongs to the ABC transporter superfamily
D2M30_04430	COG4608	Belongs to the ABC transporter superfamily
D2M30_04435	COG0753	catalase activity
D2M30_04445	COG1116	anion transmembrane transporter activity
D2M30_04450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2M30_04455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2M30_04475	COG1476	TRANSCRIPTIONal
D2M30_04485	COG3382	B3 4 domain protein
D2M30_04490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D2M30_04500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D2M30_04505	COG0789	Transcriptional regulator
D2M30_04510	COG1664	Polymer-forming cytoskeletal
D2M30_04515	COG1664	Polymer-forming cytoskeletal
D2M30_04525	COG2766	serine protein kinase
D2M30_04535	COG1846	Transcriptional regulator
D2M30_04540	COG1566	PFAM secretion protein HlyD family protein
D2M30_04545	COG2814	Major facilitator Superfamily
D2M30_04550	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2M30_04565	COG1725	Transcriptional regulator
D2M30_04570	COG1131	(ABC) transporter
D2M30_04575	COG1131	(ABC) transporter
D2M30_04580	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2M30_04585	COG1278	Cold shock
D2M30_04590	COG1464	Belongs to the NlpA lipoprotein family
D2M30_04595	COG3706	GGDEF domain
D2M30_04600	COG1823	symporter activity
D2M30_04605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2M30_04625	COG5577	PFAM Coat F domain
D2M30_04630	COG4085	toxin activity
D2M30_04630	COG1525	nuclease
D2M30_04630	COG0737	Belongs to the 5'-nucleotidase family
D2M30_04635	COG3764	Sortase (surface protein transpeptidase)
D2M30_04640	COG0564	pseudouridine synthase activity
D2M30_04650	COG0517	IMP dehydrogenase activity
D2M30_04655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2M30_04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2M30_04660	COG3153	acetyltransferase
D2M30_04665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2M30_04670	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D2M30_04675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D2M30_04685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D2M30_04690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2M30_04695	COG4585	Histidine kinase
D2M30_04695	COG2203	Gaf domain
D2M30_04700	COG2197	response regulator
D2M30_04705	COG0431	NADPH-dependent FMN reductase
D2M30_04720	COG0791	NLP P60 protein
D2M30_04720	COG1388	LysM domain
D2M30_04725	COG1959	2 iron, 2 sulfur cluster binding
D2M30_04730	COG0668	transmembrane transport
D2M30_04735	COG2719	SpoVR family
D2M30_04740	COG1785	Belongs to the alkaline phosphatase family
D2M30_04745	COG1388	LysM domain
D2M30_04745	COG0791	NLP P60 protein
D2M30_04750	COG0583	DNA-binding transcription factor activity
D2M30_04755	COG0372	Belongs to the citrate synthase family
D2M30_04760	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_04765	COG0531	amino acid
D2M30_04770	COG0733	neurotransmitter:sodium symporter activity
D2M30_04785	COG1595	DNA-templated transcription, initiation
D2M30_04790	COG0204	Acyl-transferase
D2M30_04795	COG1253	flavin adenine dinucleotide binding
D2M30_04800	COG0789	Transcriptional regulator
D2M30_04805	COG0436	Aminotransferase
D2M30_04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2M30_04815	COG1253	flavin adenine dinucleotide binding
D2M30_04820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2M30_04825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2M30_04830	COG0584	glycerophosphoryl diester phosphodiesterase
D2M30_04840	COG0668	transmembrane transport
D2M30_04845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D2M30_04850	COG0726	polysaccharide deacetylase
D2M30_04855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2M30_04860	COG3226	Transcriptional regulator
D2M30_04870	COG0589	response to stress
D2M30_04875	COG1132	(ABC) transporter
D2M30_04880	COG1132	(ABC) transporter
D2M30_04885	COG0702	epimerase
D2M30_04905	COG0189	ligase activity
D2M30_04910	COG0189	ligase activity
D2M30_04925	COG0561	phosphatase activity
D2M30_04930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2M30_04940	COG0475	glutathione-regulated potassium exporter activity
D2M30_04945	COG0490	domain, Protein
D2M30_04955	COG1024	Enoyl-CoA hydratase
D2M30_04965	COG4152	abc transporter atp-binding protein
D2M30_04970	COG1668	transmembrane transport
D2M30_04975	COG0420	3'-5' exonuclease activity
D2M30_04980	COG4717	serine-type aminopeptidase activity
D2M30_04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2M30_05035	COG4980	gas vesicle protein
D2M30_05050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D2M30_05055	COG0537	adenosine 5'-monophosphoramidase activity
D2M30_05060	COG1131	(ABC) transporter
D2M30_05065	COG4473	ABC transporter
D2M30_05075	COG1473	amidohydrolase
D2M30_05080	COG3069	C4-dicarboxylate transmembrane transporter activity
D2M30_05085	COG2329	Antibiotic biosynthesis monooxygenase
D2M30_05090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2M30_05110	COG1309	transcriptional regulator
D2M30_05115	COG1511	domain protein
D2M30_05125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2M30_05135	COG1363	Peptidase, m42
D2M30_05140	COG1301	dicarboxylic acid transport
D2M30_05150	COG1234	tRNA 3'-trailer cleavage
D2M30_05155	COG0095	Lipoate-protein ligase
D2M30_05160	COG0702	epimerase
D2M30_05165	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_05175	COG0501	Belongs to the peptidase M48B family
D2M30_05180	COG1404	Belongs to the peptidase S8 family
D2M30_05190	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D2M30_05195	COG0406	alpha-ribazole phosphatase activity
D2M30_05200	COG0183	Belongs to the thiolase family
D2M30_05205	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_05210	COG1268	BioY protein
D2M30_05215	COG0840	transmembrane signaling receptor activity
D2M30_05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2M30_05220	COG0723	plastoquinol--plastocyanin reductase activity
D2M30_05225	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_05235	COG4903	ComK protein
D2M30_05240	COG5646	InterPro IPR014922
D2M30_05265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2M30_05280	COG0398	Pfam SNARE associated Golgi protein
D2M30_05285	COG0681	Belongs to the peptidase S26 family
D2M30_05290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D2M30_05295	COG1846	Transcriptional regulator
D2M30_05300	COG3180	Ammonia monooxygenase
D2M30_05305	COG2814	Major facilitator Superfamily
D2M30_05315	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D2M30_05320	COG2323	membrane
D2M30_05335	COG0420	3'-5' exonuclease activity
D2M30_05340	COG0419	ATPase involved in DNA repair
D2M30_05345	COG1403	HNH endonuclease
D2M30_05385	COG0179	Fumarylacetoacetate (FAA) hydrolase
D2M30_05395	COG1404	Belongs to the peptidase S8 family
D2M30_05405	COG0367	asparagine synthase
D2M30_05410	COG1562	ergosterol biosynthetic process
D2M30_05415	COG0534	Mate efflux family protein
D2M30_05420	COG2207	Transcriptional regulator
D2M30_05420	COG1917	Cupin 2, conserved barrel domain protein
D2M30_05425	COG1609	Transcriptional regulator
D2M30_05430	COG0673	inositol 2-dehydrogenase activity
D2M30_05435	COG2318	DinB family
D2M30_05440	COG1279	arginine transmembrane transporter activity
D2M30_05445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2M30_05450	COG1357	PFAM Pentapeptide repeats (8 copies)
D2M30_05455	COG2153	protein acetylation
D2M30_05460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D2M30_05460	COG0646	methionine synthase
D2M30_05470	COG2996	Protein conserved in bacteria
D2M30_05480	COG0840	transmembrane signaling receptor activity
D2M30_05485	COG2124	cytochrome p450
D2M30_05495	COG1307	EDD domain protein, DegV family
D2M30_05500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_05515	COG0561	phosphatase activity
D2M30_05520	COG1073	alpha beta
D2M30_05525	COG2151	metal-sulfur cluster biosynthetic enzyme
D2M30_05535	COG0277	FAD linked oxidase domain protein
D2M30_05540	COG2271	Major facilitator Superfamily
D2M30_05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2M30_05565	COG0505	Belongs to the CarA family
D2M30_05570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2M30_05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2M30_05595	COG2267	carboxylic ester hydrolase activity
D2M30_05605	COG1744	ABC transporter substrate-binding protein PnrA-like
D2M30_05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2M30_05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2M30_05630	COG5504	Zn-dependent protease
D2M30_05635	COG0444	Belongs to the ABC transporter superfamily
D2M30_05640	COG4608	Belongs to the ABC transporter superfamily
D2M30_05650	COG0601	transmembrane transport
D2M30_05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2M30_05665	COG0180	Tryptophanyl-tRNA synthetase
D2M30_05675	COG4166	transmembrane transport
D2M30_05680	COG0601	transmembrane transport
D2M30_05685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2M30_05690	COG0444	Belongs to the ABC transporter superfamily
D2M30_05695	COG4608	Belongs to the ABC transporter superfamily
D2M30_05705	COG0456	acetyltransferase
D2M30_05710	COG1393	Belongs to the ArsC family
D2M30_05715	COG0861	Integral membrane protein TerC family
D2M30_05720	COG4862	establishment of competence for transformation
D2M30_05725	COG4469	Competence protein
D2M30_05730	COG1164	Oligoendopeptidase f
D2M30_05740	COG2346	COG2346, Truncated hemoglobins
D2M30_05745	COG0741	lytic transglycosylase activity
D2M30_05750	COG4116	CYTH
D2M30_05760	COG2357	RelA SpoT domain protein
D2M30_05765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2M30_05770	COG0564	pseudouridine synthase activity
D2M30_05780	COG0475	glutathione-regulated potassium exporter activity
D2M30_05780	COG0569	domain protein
D2M30_05785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D2M30_05790	COG0352	thiamine-phosphate diphosphorylase activity
D2M30_05795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2M30_05800	COG2104	thiamine diphosphate biosynthetic process
D2M30_05810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2M30_05815	COG0351	phosphomethylpyrimidine kinase
D2M30_05820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D2M30_05875	COG0210	DNA helicase
D2M30_05885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_05895	COG1131	(ABC) transporter
D2M30_05905	COG2153	protein acetylation
D2M30_05915	COG2382	esterase
D2M30_05920	COG0626	cystathionine gamma-synthase activity
D2M30_05925	COG0626	cystathionine gamma-synthase activity
D2M30_05945	COG4974	Belongs to the 'phage' integrase family
D2M30_06150	COG2367	Beta-lactamase
D2M30_06155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2M30_06165	COG1846	Transcriptional regulator
D2M30_06180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_06180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_06185	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2M30_06195	COG1349	DNA-binding transcription factor activity
D2M30_06215	COG1285	pathogenesis
D2M30_06225	COG2205	protein histidine kinase activity
D2M30_06235	COG3383	formate dehydrogenase (NAD+) activity
D2M30_06240	COG2427	Protein of unknown function (DUF1641)
D2M30_06245	COG2124	cytochrome p450
D2M30_06250	COG1819	glycosyl
D2M30_06260	COG1587	Uroporphyrinogen-III synthase
D2M30_06265	COG0390	transport system, permease component
D2M30_06270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2M30_06275	COG0697	spore germination
D2M30_06280	COG4297	protein containing double-stranded beta helix domain
D2M30_06290	COG1252	NADH dehydrogenase
D2M30_06300	COG1609	Transcriptional regulator
D2M30_06310	COG0745	RESPONSE REGULATOR receiver
D2M30_06315	COG5002	protein histidine kinase activity
D2M30_06330	COG0730	response to heat
D2M30_06335	COG2318	DinB family
D2M30_06340	COG0457	Tetratricopeptide repeat
D2M30_06345	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2M30_06345	COG1388	LysM domain
D2M30_06345	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_06355	COG4195	phage-related replication protein
D2M30_06360	COG2856	Zn peptidase
D2M30_06365	COG1396	sequence-specific DNA binding
D2M30_06375	COG1522	sequence-specific DNA binding
D2M30_06380	COG1484	DNA-dependent DNA replication
D2M30_06395	COG1595	DNA-templated transcription, initiation
D2M30_06400	COG3728	DNA packaging
D2M30_06400	COG5484	DNA packaging
D2M30_06405	COG1783	phage Terminase large subunit
D2M30_06410	COG5518	Phage portal protein
D2M30_06415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D2M30_06420	COG4653	Phage capsid family
D2M30_06470	COG3953	SLT domain
D2M30_06470	COG5412	phage tail tape measure protein
D2M30_06470	COG5412	phage tail tape measure protein
D2M30_06470	COG3953	SLT domain
D2M30_06475	COG1652	LysM domain
D2M30_06480	COG4193	domain, Protein
D2M30_06490	COG3628	GPW Gp25 family protein
D2M30_06495	COG3299	homolog of phage Mu protein gp47
D2M30_06500	COG3778	Protein conserved in bacteria
D2M30_06540	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_06540	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2M30_06555	COG0306	phosphate transporter
D2M30_06560	COG1392	Phosphate transport regulator
D2M30_06565	COG0531	amino acid
D2M30_06570	COG0346	lactoylglutathione lyase activity
D2M30_06575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D2M30_06580	COG0463	Glycosyl transferase, family 2
D2M30_06585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2M30_06590	COG0477	Major facilitator Superfamily
D2M30_06595	COG2362	D-Aminopeptidase
D2M30_06600	COG0601	transmembrane transport
D2M30_06605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2M30_06610	COG0444	Belongs to the ABC transporter superfamily
D2M30_06615	COG4166	transmembrane transport
D2M30_06620	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2M30_06625	COG4948	Mandelate Racemase Muconate Lactonizing
D2M30_06630	COG0791	NLP P60 protein
D2M30_06635	COG4608	Belongs to the ABC transporter superfamily
D2M30_06640	COG2706	6-phosphogluconolactonase activity
D2M30_06645	COG1834	amidinotransferase
D2M30_06650	COG1607	acyl-coa hydrolase
D2M30_06655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2M30_06660	COG2076	Multidrug Resistance protein
D2M30_06665	COG2076	Multidrug Resistance protein
D2M30_06670	COG0788	formyltetrahydrofolate deformylase activity
D2M30_06675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2M30_06685	COG1764	response to oxidative stress
D2M30_06690	COG1846	Transcriptional regulator
D2M30_06695	COG1764	response to oxidative stress
D2M30_06710	COG0457	Tetratricopeptide repeat
D2M30_06710	COG0463	Glycosyl transferase, family 2
D2M30_06725	COG2814	Major facilitator Superfamily
D2M30_06730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2M30_06740	COG1404	Belongs to the peptidase S8 family
D2M30_06745	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_06750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2M30_06755	COG1122	ATPase activity
D2M30_06760	COG4721	ABC-type cobalt transport system, permease component
D2M30_06765	COG1388	LysM domain
D2M30_06765	COG3858	chitin binding
D2M30_06780	COG2239	Acts as a magnesium transporter
D2M30_06785	COG0789	Transcriptional regulator
D2M30_06800	COG1846	Transcriptional regulator
D2M30_06805	COG0726	polysaccharide deacetylase
D2M30_06810	COG3285	dna ligase
D2M30_06810	COG1793	dna ligase
D2M30_06815	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D2M30_06820	COG5001	Diguanylate cyclase
D2M30_06820	COG3300	MHYT domain
D2M30_06825	COG0586	Pfam SNARE associated Golgi protein
D2M30_06830	COG0861	Integral membrane protein TerC family
D2M30_06835	COG1191	sigma factor activity
D2M30_06860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2M30_06865	COG2323	membrane
D2M30_06875	COG3594	Acyltransferase
D2M30_06880	COG5002	protein histidine kinase activity
D2M30_06885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2M30_06900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2M30_06905	COG0436	Aminotransferase
D2M30_06940	COG3852	Histidine kinase
D2M30_06945	COG1846	Transcriptional regulator
D2M30_06950	COG1360	Flagellar Motor Protein
D2M30_06955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2M30_06960	COG0542	response to heat
D2M30_06970	COG3949	Membrane
D2M30_06985	COG0720	synthase
D2M30_06990	COG0602	queuosine metabolic process
D2M30_07005	COG4873	Protein conserved in bacteria
D2M30_07015	COG3773	Cell wall hydrolase
D2M30_07020	COG2244	polysaccharide biosynthetic process
D2M30_07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_07030	COG2217	Heavy metal translocating P-type atpase
D2M30_07035	COG0006	proline dipeptidase activity
D2M30_07040	COG1609	Transcriptional regulator
D2M30_07045	COG3711	transcriptional antiterminator
D2M30_07050	COG2190	(PTS) system
D2M30_07050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_07050	COG1263	PTS System
D2M30_07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_07060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D2M30_07070	COG1533	DNA photolyase activity
D2M30_07075	COG0840	transmembrane signaling receptor activity
D2M30_07080	COG2084	Dehydrogenase
D2M30_07085	COG2340	Cysteine-rich secretory protein family
D2M30_07090	COG0768	penicillin binding
D2M30_07095	COG4191	Histidine kinase
D2M30_07100	COG0436	Aminotransferase
D2M30_07110	COG0784	Response regulator, receiver
D2M30_07110	COG0835	chemotaxis
D2M30_07120	COG2814	Major facilitator Superfamily
D2M30_07125	COG1376	ErfK ybiS ycfS ynhG family protein
D2M30_07130	COG1408	metallophosphoesterase
D2M30_07135	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_07145	COG2200	EAL domain
D2M30_07155	COG4703	Protein of unknown function (DUF1797)
D2M30_07160	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D2M30_07170	COG0517	IMP dehydrogenase activity
D2M30_07175	COG0583	DNA-binding transcription factor activity
D2M30_07180	COG0716	FMN binding
D2M30_07190	COG0716	FMN binding
D2M30_07210	COG0668	transmembrane transport
D2M30_07220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_07240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2M30_07245	COG0303	'Molybdopterin
D2M30_07250	COG1763	Mo-molybdopterin cofactor biosynthetic process
D2M30_07255	COG0314	molybdopterin synthase activity
D2M30_07260	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D2M30_07270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D2M30_07275	COG1136	(ABC) transporter
D2M30_07280	COG0577	efflux transmembrane transporter activity
D2M30_07285	COG1349	DNA-binding transcription factor activity
D2M30_07290	COG1105	Belongs to the carbohydrate kinase PfkB family
D2M30_07295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_07295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2M30_07295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2M30_07300	COG0681	Belongs to the peptidase S26 family
D2M30_07310	COG0488	(ABC) transporter
D2M30_07315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D2M30_07320	COG2309	aminopeptidase activity
D2M30_07330	COG1077	Cell shape determining protein MreB Mrl
D2M30_07340	COG2002	toxin-antitoxin pair type II binding
D2M30_07345	COG3852	Histidine kinase
D2M30_07350	COG2105	PFAM AIG2 family protein
D2M30_07350	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D2M30_07355	COG0569	domain protein
D2M30_07365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2M30_07380	COG0561	phosphatase activity
D2M30_07385	COG0242	peptide deformylase activity
D2M30_07395	COG0497	DNA recombination
D2M30_07410	COG4221	oxidoreductase activity
D2M30_07410	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_07410	COG3321	synthase
D2M30_07410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_07415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_07415	COG0300	oxidoreductase activity
D2M30_07415	COG3321	synthase
D2M30_07415	COG4221	oxidoreductase activity
D2M30_07425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_07425	COG0300	oxidoreductase activity
D2M30_07425	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_07425	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_07425	COG3321	synthase
D2M30_07430	COG3321	synthase
D2M30_07430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_07430	COG0300	oxidoreductase activity
D2M30_07430	COG4221	oxidoreductase activity
D2M30_07435	COG0300	oxidoreductase activity
D2M30_07435	COG3321	synthase
D2M30_07435	COG4221	oxidoreductase activity
D2M30_07435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_07440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_07440	COG4221	oxidoreductase activity
D2M30_07440	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_07440	COG3321	synthase
D2M30_07445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2M30_07450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2M30_07455	COG0022	dehydrogenase e1 component
D2M30_07460	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2M30_07465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2M30_07470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_07555	COG4896	Protein conserved in bacteria
D2M30_07565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D2M30_07570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2M30_07575	COG2066	Belongs to the glutaminase family
D2M30_07585	COG0772	Belongs to the SEDS family
D2M30_07590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D2M30_07605	COG2010	Cytochrome c
D2M30_07605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2M30_07610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2M30_07615	COG1845	cytochrome c oxidase, subunit III
D2M30_07620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D2M30_07625	COG3336	cytochrome c oxidase
D2M30_07635	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D2M30_07640	COG2340	Cysteine-rich secretory protein family
D2M30_07655	COG3679	Belongs to the UPF0342 family
D2M30_07665	COG0742	ribosomal rna small subunit methyltransferase
D2M30_07675	COG3314	Sporulation integral membrane protein YlbJ
D2M30_07680	COG1752	Esterase of the alpha-beta hydrolase superfamily
D2M30_07685	COG3480	Lon protease (S16) C-terminal proteolytic domain
D2M30_07695	COG1399	metal-binding, possibly nucleic acid-binding protein
D2M30_07700	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D2M30_07715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D2M30_07735	COG4839	cell division protein FtsL
D2M30_07745	COG0768	penicillin binding
D2M30_07765	COG0772	Belongs to the SEDS family
D2M30_07780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D2M30_07785	COG0849	cell division
D2M30_07790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D2M30_07795	COG4412	M6 family metalloprotease domain protein
D2M30_07795	COG1404	Belongs to the peptidase S8 family
D2M30_07805	COG1191	sigma factor activity
D2M30_07810	COG1191	sigma factor activity
D2M30_07815	COG1119	ATPase activity
D2M30_07820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2M30_07825	COG1873	PFAM PRC-barrel domain
D2M30_07835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D2M30_07845	COG0762	integral membrane protein
D2M30_07850	COG2302	S4 RNA-binding domain
D2M30_07855	COG3599	regulation of cell shape
D2M30_07865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D2M30_07870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2M30_07880	COG0564	pseudouridine synthase activity
D2M30_07890	COG2233	PERMEase
D2M30_07900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D2M30_07905	COG0505	Belongs to the CarA family
D2M30_07910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2M30_07925	COG0284	orotidine-5'-phosphate decarboxylase activity
D2M30_07930	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D2M30_07940	COG0306	phosphate transporter
D2M30_07955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2M30_07960	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D2M30_07965	COG1648	precorrin-2 dehydrogenase activity
D2M30_07980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D2M30_07985	COG1561	YicC-like family, N-terminal region
D2M30_07990	COG2052	Domain of unknown function (DUF370)
D2M30_07995	COG0194	GDP metabolic process
D2M30_08005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2M30_08010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2M30_08015	COG0242	peptide deformylase activity
D2M30_08025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2M30_08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D2M30_08035	COG0631	protein serine/threonine phosphatase activity
D2M30_08040	COG2815	serine threonine protein kinase
D2M30_08040	COG0515	serine threonine protein kinase
D2M30_08050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D2M30_08055	COG1564	THIamine pyrophosphokinase
D2M30_08070	COG1302	Protein conserved in bacteria
D2M30_08075	COG1461	Dihydroxyacetone kinase
D2M30_08080	COG1760	l-serine dehydratase
D2M30_08085	COG1760	l-serine dehydratase
D2M30_08090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D2M30_08105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D2M30_08110	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_08115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08125	COG1196	nuclear chromosome segregation
D2M30_08130	COG0552	protein localization to endoplasmic reticulum
D2M30_08140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D2M30_08150	COG1837	Belongs to the UPF0109 family
D2M30_08175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2M30_08190	COG2257	FlhB HrpN YscU SpaS Family
D2M30_08200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2M30_08205	COG0758	DNA mediated transformation
D2M30_08210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2M30_08220	COG4974	Belongs to the 'phage' integrase family
D2M30_08240	COG1815	bacterial-type flagellum-dependent cell motility
D2M30_08245	COG1558	bacterial-type flagellum-dependent cell motility
D2M30_08250	COG1677	Flagellar hook-basal body complex protein FliE
D2M30_08255	COG1766	The M ring may be actively involved in energy transduction
D2M30_08260	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2M30_08265	COG1317	bacterial-type flagellum organization
D2M30_08270	COG1157	protein secretion by the type III secretion system
D2M30_08275	COG2882	bacterial-type flagellum organization
D2M30_08280	COG3334	PFAM MgtE intracellular
D2M30_08285	COG3144	bacterial-type flagellum assembly
D2M30_08290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D2M30_08295	COG4786	Flagellar basal body rod
D2M30_08300	COG1582	Flagellar protein (FlbD)
D2M30_08305	COG1580	Controls the rotational direction of flagella during chemotaxis
D2M30_08310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2M30_08315	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2M30_08315	COG1776	CheC inhibitor of MCP methylation
D2M30_08320	COG2201	protein-glutamate methylesterase activity
D2M30_08325	COG3190	flagellar
D2M30_08330	COG1338	Plays a role in the flagellum-specific transport system
D2M30_08335	COG1987	bacterial-type flagellum assembly
D2M30_08340	COG1684	flagellar biosynthetic protein fliR
D2M30_08345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2M30_08350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2M30_08355	COG1419	protein localization to endoplasmic reticulum
D2M30_08360	COG0455	bacterial-type flagellum organization
D2M30_08365	COG2201	protein-glutamate methylesterase activity
D2M30_08370	COG2198	Histidine kinase
D2M30_08370	COG0643	Histidine kinase
D2M30_08375	COG0835	chemotaxis
D2M30_08380	COG1776	CheC inhibitor of MCP methylation
D2M30_08390	COG1191	sigma factor activity
D2M30_08420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D2M30_08425	COG4589	Belongs to the CDS family
D2M30_08435	COG0750	zinc metalloprotease
D2M30_08445	COG2176	DNA-directed DNA polymerase activity
D2M30_08455	COG0195	Participates in both transcription termination and antitermination
D2M30_08460	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D2M30_08465	COG1358	cellular component organization or biogenesis
D2M30_08475	COG1550	Protein conserved in bacteria
D2M30_08490	COG0196	riboflavin kinase activity
D2M30_08505	COG0726	polysaccharide deacetylase
D2M30_08510	COG0612	Peptidase, M16
D2M30_08515	COG1873	PFAM PRC-barrel domain
D2M30_08520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2M30_08525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2M30_08530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D2M30_08535	COG0527	aspartate kinase activity
D2M30_08545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2M30_08550	COG0740	serine-type endopeptidase activity
D2M30_08560	COG4980	gas vesicle protein
D2M30_08560	COG1674	ftsk spoiiie
D2M30_08565	COG2188	Transcriptional regulator
D2M30_08570	COG2814	Major facilitator Superfamily
D2M30_08575	COG1846	Transcriptional regulator
D2M30_08580	COG2409	Drug exporters of the RND superfamily
D2M30_08580	COG1033	growth of symbiont in host cell
D2M30_08585	COG0612	Peptidase, M16
D2M30_08590	COG0612	Peptidase, M16
D2M30_08595	COG0300	oxidoreductase activity
D2M30_08610	COG1426	Protein conserved in bacteria
D2M30_08615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D2M30_08630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2M30_08640	COG1692	metallophosphoesterase
D2M30_08645	COG2359	stage V sporulation protein S
D2M30_08665	COG4550	Control of competence regulator ComK, YlbF/YmcA
D2M30_08705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08710	COG3425	synthase
D2M30_08715	COG1024	Enoyl-CoA hydratase
D2M30_08720	COG1024	Enoyl-CoA hydratase
D2M30_08725	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_08725	COG0300	oxidoreductase activity
D2M30_08725	COG3321	synthase
D2M30_08725	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_08725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_08730	COG0300	oxidoreductase activity
D2M30_08730	COG4221	oxidoreductase activity
D2M30_08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08730	COG3321	synthase
D2M30_08735	COG3321	synthase
D2M30_08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2M30_08735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2M30_08735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_08735	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_08735	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_08735	COG3321	synthase
D2M30_08740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_08740	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_08740	COG3321	synthase
D2M30_08740	COG4221	oxidoreductase activity
D2M30_08745	COG3321	synthase
D2M30_08745	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D2M30_08745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D2M30_08745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2M30_08750	COG2124	cytochrome p450
D2M30_08755	COG3209	COG3209 Rhs family protein
D2M30_08760	COG3619	membrane
D2M30_08770	COG1404	Belongs to the peptidase S8 family
D2M30_08780	COG4195	phage-related replication protein
D2M30_08785	COG1764	response to oxidative stress
D2M30_08795	COG2076	Multidrug Resistance protein
D2M30_08835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2M30_08840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2M30_08845	COG4112	unkown
D2M30_08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_08860	COG0464	growth
D2M30_08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D2M30_08870	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D2M30_08875	COG0789	Transcriptional regulator
D2M30_08880	COG0174	glutamine synthetase
D2M30_08885	COG0726	polysaccharide deacetylase
D2M30_08890	COG2124	cytochrome p450
D2M30_08895	COG2211	Major facilitator Superfamily
D2M30_08900	COG3507	Belongs to the glycosyl hydrolase 43 family
D2M30_08915	COG1070	Carbohydrate kinase
D2M30_08925	COG3848	Pyruvate phosphate dikinase
D2M30_08925	COG0574	Belongs to the PEP-utilizing enzyme family
D2M30_08955	COG2318	DinB family
D2M30_08960	COG1064	alcohol dehydrogenase
D2M30_09020	COG3397	chitin binding
D2M30_09040	COG5434	Belongs to the glycosyl hydrolase 28 family
D2M30_09045	COG2314	TM2 domain
D2M30_09050	COG0756	dUTP diphosphatase activity
D2M30_09060	COG4195	phage-related replication protein
D2M30_09090	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D2M30_09100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D2M30_09120	COG0785	Cytochrome C biogenesis protein
D2M30_09125	COG2201	protein-glutamate methylesterase activity
D2M30_09130	COG4846	Membrane protein involved in cytochrome C biogenesis
D2M30_09140	COG0071	Belongs to the small heat shock protein (HSP20) family
D2M30_09155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D2M30_09160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_09180	COG0824	Thioesterase
D2M30_09190	COG4841	protein insertion into membrane
D2M30_09200	COG1832	CoA-binding protein
D2M30_09205	COG0187	DNA topoisomerase II activity
D2M30_09210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2M30_09220	COG1115	amino acid carrier protein
D2M30_09245	COG2205	protein histidine kinase activity
D2M30_09250	COG0745	RESPONSE REGULATOR receiver
D2M30_09260	COG3507	Belongs to the glycosyl hydrolase 43 family
D2M30_09290	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_09295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D2M30_09300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D2M30_09305	COG2124	cytochrome p450
D2M30_09310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D2M30_09325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2M30_09335	COG2246	polysaccharide biosynthetic process
D2M30_09340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2M30_09345	COG0586	Pfam SNARE associated Golgi protein
D2M30_09350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2M30_09355	COG1024	Enoyl-CoA hydratase
D2M30_09360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D2M30_09365	COG0511	ligase activity, forming carbon-carbon bonds
D2M30_09370	COG0439	Biotin carboxylase
D2M30_09375	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_09380	COG1960	acyl-CoA dehydrogenase activity
D2M30_09385	COG1649	PFAM Uncharacterised BCR, COG1649
D2M30_09395	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D2M30_09395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_09400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_09405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_09410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_09415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_09425	COG2027	D-alanyl-D-alanine carboxypeptidase
D2M30_09430	COG2017	converts alpha-aldose to the beta-anomer
D2M30_09435	COG0534	Mate efflux family protein
D2M30_09445	COG5444	nuclease activity
D2M30_09480	COG0582	viral genome integration into host DNA
D2M30_09485	COG0166	Belongs to the GPI family
D2M30_09490	COG0405	Gamma-glutamyltransferase
D2M30_09495	COG2814	Major facilitator Superfamily
D2M30_09500	COG0640	Transcriptional regulator
D2M30_09505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2M30_09515	COG0604	alcohol dehydrogenase
D2M30_09525	COG0493	'glutamate synthase
D2M30_09530	COG0069	glutamate synthase activity
D2M30_09530	COG0070	glutamate synthase
D2M30_09530	COG0067	glutamate synthase
D2M30_09535	COG0583	DNA-binding transcription factor activity
D2M30_09540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2M30_09555	COG0300	oxidoreductase activity
D2M30_09560	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D2M30_09570	COG2814	Major facilitator Superfamily
D2M30_09575	COG1070	Carbohydrate kinase
D2M30_09580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D2M30_09585	COG0243	molybdopterin cofactor binding
D2M30_09640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2M30_09645	COG0662	Cupin 2, conserved barrel domain protein
D2M30_09645	COG2207	Transcriptional regulator
D2M30_09650	COG1309	transcriptional regulator
D2M30_09655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_09665	COG0640	Transcriptional regulator
D2M30_09670	COG0741	lytic transglycosylase activity
D2M30_09675	COG2322	membrane
D2M30_09690	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2M30_09700	COG3584	3D domain protein
D2M30_09700	COG1388	LysM domain
D2M30_09705	COG0514	ATP-dependent DNA helicase (RecQ)
D2M30_09715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2M30_09720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2M30_09735	COG0071	Belongs to the small heat shock protein (HSP20) family
D2M30_09765	COG1012	belongs to the aldehyde dehydrogenase family
D2M30_09770	COG1657	PFAM Prenyltransferase squalene oxidase
D2M30_09775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2M30_09780	COG0733	neurotransmitter:sodium symporter activity
D2M30_09785	COG0385	Bile acid
D2M30_09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_09795	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2M30_09805	COG4548	von Willebrand factor, type A
D2M30_09810	COG0714	Associated with various cellular activities
D2M30_09815	COG2032	superoxide dismutase activity
D2M30_09820	COG0791	NLP P60 protein
D2M30_09820	COG1388	LysM domain
D2M30_09830	COG1819	glycosyl
D2M30_09835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D2M30_09840	COG0534	Mate efflux family protein
D2M30_09845	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_09850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2M30_09855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2M30_09865	COG2962	Rard protein
D2M30_09880	COG1942	4-Oxalocrotonate Tautomerase
D2M30_09890	COG1733	regulation of RNA biosynthetic process
D2M30_09895	COG0778	Nitroreductase
D2M30_09900	COG0400	carboxylic ester hydrolase activity
D2M30_09905	COG0346	lactoylglutathione lyase activity
D2M30_09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2M30_09925	COG2723	6-phospho-beta-galactosidase activity
D2M30_09930	COG2188	Transcriptional regulator
D2M30_09935	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_09935	COG0793	Belongs to the peptidase S41A family
D2M30_09940	COG2226	methyltransferase
D2M30_09950	COG1876	peptidase activity
D2M30_09970	COG0671	phosphoesterase, PA-phosphatase related
D2M30_09985	COG0346	lactoylglutathione lyase activity
D2M30_10000	COG1509	lysine 2,3-aminomutase activity
D2M30_10005	COG0456	acetyltransferase
D2M30_10010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2M30_10015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D2M30_10020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D2M30_10025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2M30_10035	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D2M30_10045	COG0456	acetyltransferase
D2M30_10050	COG0463	Glycosyl transferase, family 2
D2M30_10065	COG4641	Protein conserved in bacteria
D2M30_10075	COG1086	Polysaccharide biosynthesis protein
D2M30_10105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D2M30_10110	COG1086	Polysaccharide biosynthesis protein
D2M30_10125	COG1846	Transcriptional regulator
D2M30_10130	COG4698	Protein conserved in bacteria
D2M30_10135	COG2755	lipolytic protein G-D-S-L family
D2M30_10140	COG1999	signal sequence binding
D2M30_10150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D2M30_10155	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D2M30_10160	COG1272	protein, Hemolysin III
D2M30_10165	COG0204	Acyl-transferase
D2M30_10170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2M30_10185	COG2521	methyltransferase
D2M30_10185	COG2136	Putative SAM-dependent methyltransferase
D2M30_10200	COG1413	lyase activity
D2M30_10205	COG1418	mRNA catabolic process
D2M30_10210	COG0386	Belongs to the glutathione peroxidase family
D2M30_10220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2M30_10225	COG1278	Cold shock
D2M30_10245	COG0328	RNA-DNA hybrid ribonuclease activity
D2M30_10250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D2M30_10255	COG0328	RNA-DNA hybrid ribonuclease activity
D2M30_10265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2M30_10280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2M30_10290	COG1755	Isoprenylcysteine carboxyl methyltransferase
D2M30_10295	COG3424	synthase
D2M30_10325	COG3331	DNA recombination
D2M30_10380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D2M30_10410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2M30_10450	COG0756	dUTP diphosphatase activity
D2M30_10460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_10495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2M30_10495	COG1372	Participates in initiation and elongation during chromosome replication
D2M30_10500	COG1780	Probably involved in ribonucleotide reductase function
D2M30_10560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D2M30_10570	COG3584	3D domain protein
D2M30_10575	COG0587	DNA-directed DNA polymerase activity
D2M30_10580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D2M30_10585	COG0358	DNA primase activity
D2M30_10590	COG0305	Participates in initiation and elongation during chromosome replication
D2M30_10600	COG2887	Belongs to the helicase family. UvrD subfamily
D2M30_10635	COG3420	alginic acid biosynthetic process
D2M30_10635	COG5434	Belongs to the glycosyl hydrolase 28 family
D2M30_10640	COG4195	phage-related replication protein
D2M30_10670	COG2135	peptidase activity
D2M30_10775	COG3655	Transcriptional regulator
D2M30_10870	COG3655	Transcriptional regulator
D2M30_10990	COG0776	regulation of translation
D2M30_11110	COG0582	viral genome integration into host DNA
D2M30_11200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2M30_11240	COG5444	nuclease activity
D2M30_11250	COG4282	regulation of fungal-type cell wall biogenesis
D2M30_11255	COG1525	nuclease
D2M30_11260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D2M30_11275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D2M30_11280	COG1199	ATP-dependent helicase activity
D2M30_11295	COG0116	Belongs to the methyltransferase superfamily
D2M30_11320	COG3359	exonuclease
D2M30_11325	COG1111	helicase
D2M30_11325	COG1205	dead DEAH box helicase
D2M30_11330	COG2190	(PTS) system
D2M30_11335	COG0071	Belongs to the small heat shock protein (HSP20) family
D2M30_11375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2M30_11375	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2M30_11385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D2M30_11390	COG3935	DnaD domain protein
D2M30_11400	COG0436	Aminotransferase
D2M30_11405	COG5353	protein conserved in bacteria
D2M30_11415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D2M30_11415	COG1199	ATP-dependent helicase activity
D2M30_11445	COG0438	transferase activity, transferring glycosyl groups
D2M30_11450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2M30_11465	COG1694	Mazg nucleotide pyrophosphohydrolase
D2M30_11470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_11475	COG2140	Oxalate decarboxylase
D2M30_11485	COG4347	Protein of unknown function (DUF1405)
D2M30_11490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2M30_11490	COG2010	Cytochrome c
D2M30_11495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2M30_11500	COG0723	plastoquinol--plastocyanin reductase activity
D2M30_11515	COG0457	Tetratricopeptide repeat
D2M30_11525	COG0287	Prephenate dehydrogenase
D2M30_11560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2M30_11565	COG4401	Chorismate mutase type I
D2M30_11580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D2M30_11585	COG0105	UTP biosynthetic process
D2M30_11590	COG0142	geranyltranstransferase activity
D2M30_11600	COG0142	geranyltranstransferase activity
D2M30_11615	COG0776	regulation of translation
D2M30_11620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2M30_11660	COG0539	negative regulation of cytoplasmic translation
D2M30_11670	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D2M30_11675	COG2959	enzyme of heme biosynthesis
D2M30_11680	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_11680	COG3773	Cell wall hydrolase
D2M30_11685	COG2339	peptidase activity
D2M30_11690	COG0492	ferredoxin-NADP+ reductase activity
D2M30_11695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2M30_11700	COG4862	establishment of competence for transformation
D2M30_11705	COG1408	metallophosphoesterase
D2M30_11715	COG1388	LysM domain
D2M30_11720	COG1266	CAAX protease self-immunity
D2M30_11725	COG0514	ATP-dependent DNA helicase (RecQ)
D2M30_11730	COG4955	Helix-turn-helix domain
D2M30_11735	COG1141	Ferredoxin
D2M30_11740	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D2M30_11745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D2M30_11755	COG1595	DNA-templated transcription, initiation
D2M30_11760	COG5002	protein histidine kinase activity
D2M30_11765	COG0745	RESPONSE REGULATOR receiver
D2M30_11770	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2M30_11775	COG1333	cytochrome c biogenesis protein
D2M30_11780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_11785	COG1187	pseudouridine synthase activity
D2M30_11790	COG0700	Nucleoside recognition
D2M30_11795	COG2715	membrane protein required for spore maturation
D2M30_11800	COG1686	Belongs to the peptidase S11 family
D2M30_11825	COG1547	Domain of unknown function (DUF309)
D2M30_11835	COG0456	acetyltransferase
D2M30_11840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D2M30_11850	COG0307	riboflavin synthase, alpha
D2M30_11855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2M30_11855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2M30_11865	COG0681	Belongs to the peptidase S26 family
D2M30_11875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D2M30_11880	COG4086	secreted protein
D2M30_11885	COG0019	diaminopimelate decarboxylase activity
D2M30_11890	COG0697	spore germination
D2M30_11905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2M30_11925	COG1191	sigma factor activity
D2M30_11935	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_11940	COG1686	Belongs to the peptidase S11 family
D2M30_11945	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D2M30_11950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2M30_11955	COG4974	Belongs to the 'phage' integrase family
D2M30_11965	COG0735	belongs to the Fur family
D2M30_11970	COG1300	Membrane
D2M30_11985	COG0281	malic enzyme
D2M30_11990	COG1757	Na H antiporter
D2M30_11995	COG1027	Aspartate ammonia-lyase
D2M30_12000	COG0252	asparaginase activity
D2M30_12005	COG1396	sequence-specific DNA binding
D2M30_12010	COG1379	DNA repair
D2M30_12015	COG0494	nUDIX hydrolase
D2M30_12025	COG0667	Aldo Keto reductase
D2M30_12035	COG1073	alpha beta
D2M30_12045	COG4918	Iron-sulphur cluster biosynthesis
D2M30_12050	COG0456	acetyltransferase
D2M30_12050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D2M30_12055	COG0456	acetyltransferase
D2M30_12060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2M30_12075	COG0628	permease
D2M30_12090	COG3048	D-serine ammonia-lyase activity
D2M30_12095	COG0300	oxidoreductase activity
D2M30_12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_12105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2M30_12110	COG2070	2-Nitropropane dioxygenase
D2M30_12110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D2M30_12115	COG0250	Participates in transcription elongation, termination and antitermination
D2M30_12140	COG0596	Alpha beta hydrolase
D2M30_12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D2M30_12160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D2M30_12175	COG0706	membrane insertase activity
D2M30_12180	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2M30_12185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2M30_12190	COG0346	lactoylglutathione lyase activity
D2M30_12195	COG1376	ErfK ybiS ycfS ynhG family protein
D2M30_12200	COG4129	membrane
D2M30_12205	COG1126	abc transporter atp-binding protein
D2M30_12210	COG0765	amino acid transport
D2M30_12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_12225	COG1597	lipid kinase activity
D2M30_12230	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2M30_12235	COG0022	dehydrogenase e1 component
D2M30_12240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2M30_12245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2M30_12250	COG3426	butyrate kinase activity
D2M30_12255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2M30_12260	COG0280	phosphate acetyltransferase
D2M30_12265	COG3290	protein histidine kinase activity
D2M30_12265	COG3829	transcription factor binding
D2M30_12275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D2M30_12280	COG2079	MmgE PrpD family protein
D2M30_12285	COG0372	Belongs to the citrate synthase family
D2M30_12290	COG1960	acyl-CoA dehydrogenase activity
D2M30_12295	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2M30_12300	COG0183	Belongs to the thiolase family
D2M30_12305	COG0584	glycerophosphoryl diester phosphodiesterase
D2M30_12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_12345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2M30_12350	COG0745	RESPONSE REGULATOR receiver
D2M30_12355	COG0750	zinc metalloprotease
D2M30_12360	COG0497	DNA recombination
D2M30_12370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D2M30_12380	COG0142	geranyltranstransferase activity
D2M30_12390	COG1570	exodeoxyribonuclease VII activity
D2M30_12405	COG1302	Protein conserved in bacteria
D2M30_12410	COG0439	Biotin carboxylase
D2M30_12415	COG0511	ligase activity, forming carbon-carbon bonds
D2M30_12455	COG3854	ATPases associated with a variety of cellular activities
D2M30_12470	COG0006	proline dipeptidase activity
D2M30_12480	COG3872	metal-dependent enzyme
D2M30_12490	COG1752	Esterase of the alpha-beta hydrolase superfamily
D2M30_12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2M30_12525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2M30_12540	COG1396	sequence-specific DNA binding
D2M30_12550	COG0681	Belongs to the peptidase S26 family
D2M30_12575	COG4940	Competence protein ComGF
D2M30_12585	COG4970	Tfp pilus assembly protein FimT
D2M30_12590	COG4537	Required for transformation and DNA binding
D2M30_12595	COG1459	type II secretion system
D2M30_12600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D2M30_12610	COG1253	flavin adenine dinucleotide binding
D2M30_12615	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_12625	COG1393	Belongs to the ArsC family
D2M30_12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_12645	COG0011	TIGRFAM Protein of
D2M30_12655	COG2866	Carboxypeptidase
D2M30_12660	COG1940	carbohydrate kinase activity
D2M30_12665	COG4483	Protein conserved in bacteria
D2M30_12670	COG1757	Na H antiporter
D2M30_12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D2M30_12685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2M30_12695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2M30_12700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2M30_12705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2M30_12710	COG0581	inorganic phosphate transmembrane transporter activity
D2M30_12715	COG0573	inorganic phosphate transmembrane transporter activity
D2M30_12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D2M30_12730	COG0477	Major facilitator Superfamily
D2M30_12735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2M30_12740	COG2839	Protein conserved in bacteria
D2M30_12745	COG5521	maltodextrose utilization protein MalA
D2M30_12750	COG1388	LysM domain
D2M30_12760	COG4709	membrane
D2M30_12765	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D2M30_12770	COG0735	belongs to the Fur family
D2M30_12790	COG0513	Belongs to the DEAD box helicase family
D2M30_12805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D2M30_12810	COG2384	SAM-dependent methyltransferase
D2M30_12815	COG2010	Cytochrome c
D2M30_12820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D2M30_12825	COG0358	DNA primase activity
D2M30_12840	COG0517	IMP dehydrogenase activity
D2M30_12845	COG0751	glycine-tRNA ligase activity
D2M30_12865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D2M30_12870	COG0295	cytidine deaminase activity
D2M30_12875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D2M30_12885	COG1480	7TM receptor with intracellular HD hydrolase
D2M30_12890	COG1702	phosphate starvation-inducible protein PhoH
D2M30_12895	COG0561	phosphatase activity
D2M30_12910	COG4864	UPF0365 protein
D2M30_12915	COG1030	water channel activity
D2M30_12920	COG1610	YqeY-like protein
D2M30_12925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D2M30_12930	COG1283	sodium-dependent phosphate transmembrane transporter activity
D2M30_12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D2M30_12940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D2M30_12970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2M30_12985	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_13000	COG1466	dna polymerase III delta subunit
D2M30_13010	COG0658	competence protein
D2M30_13010	COG2333	competence protein COMEC
D2M30_13015	COG2131	deaminase
D2M30_13020	COG1555	photosystem II stabilization
D2M30_13020	COG1596	polysaccharide export
D2M30_13025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2M30_13030	COG2226	methyltransferase
D2M30_13035	COG0799	negative regulation of ribosome biogenesis
D2M30_13040	COG1713	HD superfamily hydrolase involved in NAD metabolism
D2M30_13050	COG1534	Rna-binding protein
D2M30_13055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D2M30_13060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2M30_13065	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D2M30_13075	COG2755	lipolytic protein G-D-S-L family
D2M30_13080	COG0726	polysaccharide deacetylase
D2M30_13085	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_13085	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2M30_13090	COG0398	Pfam SNARE associated Golgi protein
D2M30_13155	COG0563	adenylate kinase activity
D2M30_13165	COG2814	Major facilitator Superfamily
D2M30_13180	COG2318	DinB family
D2M30_13185	COG0561	phosphatase activity
D2M30_13190	COG0561	phosphatase activity
D2M30_13200	COG1482	cell wall glycoprotein biosynthetic process
D2M30_13205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_13205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2M30_13205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2M30_13210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_13210	COG3711	transcriptional antiterminator
D2M30_13220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D2M30_13225	COG0583	DNA-binding transcription factor activity
D2M30_13230	COG2814	Major facilitator Superfamily
D2M30_13235	COG2124	cytochrome p450
D2M30_13235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2M30_13240	COG1309	transcriptional regulator
D2M30_13245	COG2226	methyltransferase
D2M30_13255	COG2116	formate transmembrane transporter activity
D2M30_13260	COG5609	conserved protein (DUF2294)
D2M30_13265	COG3383	formate dehydrogenase (NAD+) activity
D2M30_13270	COG2427	Protein of unknown function (DUF1641)
D2M30_13280	COG0626	cystathionine gamma-synthase activity
D2M30_13285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2M30_13310	COG0768	penicillin binding
D2M30_13345	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2M30_13345	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_13350	COG4824	toxin secretion phage lysis holin
D2M30_13370	COG5434	Belongs to the glycosyl hydrolase 28 family
D2M30_13375	COG1705	Flagellar rod assembly protein muramidase FlgJ
D2M30_13385	COG3953	SLT domain
D2M30_13385	COG5280	Phage tail tape measure protein TP901
D2M30_13475	COG0582	viral genome integration into host DNA
D2M30_13480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D2M30_13575	COG1396	sequence-specific DNA binding
D2M30_13610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2M30_13625	COG4472	Bacterial protein of unknown function (DUF965)
D2M30_13635	COG0628	permease
D2M30_13640	COG1126	abc transporter atp-binding protein
D2M30_13645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_13650	COG0765	amino acid transport
D2M30_13655	COG0765	amino acid transport
D2M30_13670	COG3881	PFAM PRC-barrel domain
D2M30_13675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2M30_13680	COG0457	Tetratricopeptide repeat
D2M30_13690	COG1104	cysteine desulfurase activity
D2M30_13695	COG1959	2 iron, 2 sulfur cluster binding
D2M30_13700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D2M30_13705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D2M30_13730	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_13730	COG4991	sh3 domain protein
D2M30_13730	COG3103	Sh3 type 3 domain protein
D2M30_13735	COG1490	D-aminoacyl-tRNA deacylase activity
D2M30_13740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D2M30_13750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D2M30_13750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D2M30_13755	COG5416	Lipopolysaccharide assembly protein A domain
D2M30_13760	COG0490	domain, Protein
D2M30_13765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2M30_13765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2M30_13775	COG2244	polysaccharide biosynthetic process
D2M30_13780	COG2323	membrane
D2M30_13790	COG1862	Preprotein translocase
D2M30_13830	COG1388	LysM domain
D2M30_13840	COG0157	Belongs to the NadC ModD family
D2M30_13845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D2M30_13850	COG1104	cysteine desulfurase activity
D2M30_13855	COG1827	regulation of RNA biosynthetic process
D2M30_13860	COG0077	Prephenate dehydratase
D2M30_13875	COG3290	protein histidine kinase activity
D2M30_13880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D2M30_13885	COG2868	ribosomal protein
D2M30_13895	COG1994	Peptidase M50
D2M30_13900	COG0739	heme binding
D2M30_13905	COG2894	cell division
D2M30_13910	COG0850	regulation of cytokinetic process
D2M30_13915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D2M30_13920	COG1792	Involved in formation and maintenance of cell shape
D2M30_13925	COG1077	Cell shape determining protein MreB Mrl
D2M30_13945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D2M30_13950	COG0285	dihydrofolate synthase activity
D2M30_13955	COG0525	valine-tRNA ligase activity
D2M30_13965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2M30_13970	COG1388	LysM domain
D2M30_13980	COG0113	porphobilinogen synthase activity
D2M30_13985	COG1587	Uroporphyrinogen-III synthase
D2M30_13995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2M30_14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D2M30_14020	COG1067	ATP-dependent peptidase activity
D2M30_14020	COG0470	DNA polymerase III
D2M30_14035	COG1477	protein flavinylation
D2M30_14035	COG0457	Tetratricopeptide repeat
D2M30_14050	COG0473	3-isopropylmalate dehydrogenase activity
D2M30_14065	COG0440	acetolactate synthase activity
D2M30_14070	COG0028	Belongs to the TPP enzyme family
D2M30_14095	COG0622	Phosphoesterase
D2M30_14100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D2M30_14110	COG5401	PFAM Sporulation and spore germination
D2M30_14120	COG1846	Transcriptional regulator
D2M30_14125	COG2197	response regulator
D2M30_14130	COG0824	Thioesterase
D2M30_14135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D2M30_14140	COG1053	succinate dehydrogenase
D2M30_14145	COG2009	succinate dehydrogenase
D2M30_14150	COG1719	4-vinyl reductase, 4VR
D2M30_14155	COG0527	aspartate kinase activity
D2M30_14165	COG3118	belongs to the thioredoxin family
D2M30_14170	COG3534	alpha-L-arabinofuranosidase
D2M30_14175	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D2M30_14180	COG2086	electron transfer activity
D2M30_14185	COG1024	Enoyl-CoA hydratase
D2M30_14190	COG1309	transcriptional regulator
D2M30_14195	COG0318	PFAM AMP-dependent synthetase and ligase
D2M30_14205	COG3766	membrane
D2M30_14215	COG1796	DNA polymerase
D2M30_14215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2M30_14220	COG1286	toxin biosynthetic process
D2M30_14235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2M30_14235	COG0072	phenylalanine-tRNA ligase activity
D2M30_14240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D2M30_14245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2M30_14255	COG3835	regulator
D2M30_14265	COG0247	lactate metabolic process
D2M30_14270	COG1966	Carbon starvation protein
D2M30_14275	COG3534	alpha-L-arabinofuranosidase
D2M30_14280	COG0395	ABC-type sugar transport system, permease component
D2M30_14285	COG1175	transmembrane transport
D2M30_14290	COG1653	transport
D2M30_14300	COG0647	UMP catabolic process
D2M30_14305	COG0235	Class ii aldolase
D2M30_14310	COG1069	ribulokinase activity
D2M30_14315	COG2160	L-arabinose isomerase activity
D2M30_14320	COG3507	Belongs to the glycosyl hydrolase 43 family
D2M30_14325	COG1363	Peptidase, m42
D2M30_14335	COG3326	Membrane
D2M30_14340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D2M30_14345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D2M30_14350	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D2M30_14355	COG1346	cytolysis
D2M30_14360	COG1380	Effector of murein hydrolase LrgA
D2M30_14365	COG3279	Response regulator of the LytR AlgR family
D2M30_14370	COG3275	phosphorelay sensor kinase activity
D2M30_14390	COG0398	Pfam SNARE associated Golgi protein
D2M30_14395	COG1484	DNA-dependent DNA replication
D2M30_14400	COG3611	Membrane attachment protein
D2M30_14415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2M30_14420	COG1733	regulation of RNA biosynthetic process
D2M30_14425	COG2814	Major facilitator Superfamily
D2M30_14430	COG0656	L-ascorbic acid biosynthetic process
D2M30_14435	COG0237	dephospho-CoA kinase activity
D2M30_14440	COG1971	Probably functions as a manganese efflux pump
D2M30_14445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D2M30_14450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2M30_14450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2M30_14455	COG5002	protein histidine kinase activity
D2M30_14460	COG0745	RESPONSE REGULATOR receiver
D2M30_14470	COG0538	isocitrate dehydrogenase activity
D2M30_14475	COG0372	Belongs to the citrate synthase family
D2M30_14485	COG0628	permease
D2M30_14490	COG3030	protein affecting phage T7 exclusion by the F plasmid
D2M30_14495	COG0469	pyruvate kinase activity
D2M30_14515	COG0281	malic enzyme
D2M30_14520	COG0587	DNA-directed DNA polymerase activity
D2M30_14540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D2M30_14550	COG4109	DRTGG domain
D2M30_14560	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_14575	COG0521	Mo-molybdopterin cofactor biosynthetic process
D2M30_14585	COG0827	DNA restriction-modification system
D2M30_14590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D2M30_14595	COG3874	Sporulation protein YtfJ
D2M30_14605	COG1714	RDD family
D2M30_14610	COG0616	signal peptide processing
D2M30_14615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2M30_14620	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D2M30_14625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2M30_14640	COG1104	cysteine desulfurase activity
D2M30_14645	COG1114	Component of the transport system for branched-chain amino acids
D2M30_14655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2M30_14660	COG1309	transcriptional regulator
D2M30_14665	COG1956	GAF domain-containing protein
D2M30_14670	COG2199	diguanylate cyclase activity
D2M30_14670	COG2203	Gaf domain
D2M30_14685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D2M30_14685	COG1017	nitric oxide dioxygenase activity
D2M30_14710	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2M30_14715	COG1378	Sugar-specific transcriptional regulator TrmB
D2M30_14720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D2M30_14735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2M30_14740	COG0454	-acetyltransferase
D2M30_14745	COG0517	IMP dehydrogenase activity
D2M30_14750	COG0123	including yeast histone deacetylase and acetoin utilization protein
D2M30_14755	COG1360	Flagellar Motor Protein
D2M30_14760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2M30_14765	COG1609	Transcriptional regulator
D2M30_14770	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D2M30_14770	COG1605	Chorismate mutase
D2M30_14775	COG3118	belongs to the thioredoxin family
D2M30_14780	COG4980	gas vesicle protein
D2M30_14785	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D2M30_14795	COG1674	ftsk spoiiie
D2M30_14800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2M30_14810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_14820	COG1363	Peptidase, m42
D2M30_14825	COG5584	Small secreted protein
D2M30_14830	COG0281	malic enzyme
D2M30_14835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2M30_14850	COG0510	thiamine kinase activity
D2M30_14855	COG1597	lipid kinase activity
D2M30_14865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D2M30_14870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2M30_14875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2M30_14880	COG2252	PERMEase
D2M30_14885	COG4473	ABC transporter
D2M30_14890	COG1131	(ABC) transporter
D2M30_14895	COG1349	DNA-binding transcription factor activity
D2M30_14900	COG1187	pseudouridine synthase activity
D2M30_14905	COG2244	polysaccharide biosynthetic process
D2M30_14910	COG2081	HI0933 family
D2M30_14915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D2M30_14945	COG1486	melibiose metabolic process
D2M30_14955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2M30_14970	COG2202	Pas domain
D2M30_14970	COG1366	Belongs to the anti-sigma-factor antagonist family
D2M30_14975	COG2814	Major facilitator Superfamily
D2M30_14980	COG5522	Integral membrane protein (intg_mem_TP0381)
D2M30_14985	COG0577	efflux transmembrane transporter activity
D2M30_14990	COG1136	(ABC) transporter
D2M30_14995	COG2205	protein histidine kinase activity
D2M30_15000	COG0745	RESPONSE REGULATOR receiver
D2M30_15005	COG0577	efflux transmembrane transporter activity
D2M30_15010	COG1136	(ABC) transporter
D2M30_15030	COG1131	(ABC) transporter
D2M30_15035	COG1725	Transcriptional regulator
D2M30_15045	COG1242	4 iron, 4 sulfur cluster binding
D2M30_15050	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D2M30_15065	COG2267	carboxylic ester hydrolase activity
D2M30_15070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D2M30_15075	COG1113	amino acid transport
D2M30_15080	COG0367	asparagine synthase
D2M30_15100	COG1506	peptidase
D2M30_15105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2M30_15110	COG1116	anion transmembrane transporter activity
D2M30_15115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2M30_15120	COG0494	nUDIX hydrolase
D2M30_15125	COG4824	toxin secretion phage lysis holin
D2M30_15130	COG0783	Belongs to the Dps family
D2M30_15155	COG0288	reversible hydration of carbon dioxide
D2M30_15165	COG1271	oxidase subunit
D2M30_15170	COG1294	oxidase, subunit
D2M30_15180	COG4948	Mandelate Racemase Muconate Lactonizing
D2M30_15190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D2M30_15195	COG0596	Alpha beta hydrolase
D2M30_15205	COG1169	isochorismate synthase
D2M30_15210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2M30_15215	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D2M30_15340	COG3859	Proton-coupled thiamine transporter YuaJ
D2M30_15345	COG2268	Band 7 protein
D2M30_15350	COG1585	Membrane protein implicated in regulation of membrane protease activity
D2M30_15355	COG2318	DinB family
D2M30_15365	COG1454	alcohol dehydrogenase
D2M30_15375	COG1510	regulation of RNA biosynthetic process
D2M30_15385	COG0569	domain protein
D2M30_15390	COG1705	Flagellar rod assembly protein muramidase FlgJ
D2M30_15395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D2M30_15395	COG1017	nitric oxide dioxygenase activity
D2M30_15420	COG0628	permease
D2M30_15425	COG0673	inositol 2-dehydrogenase activity
D2M30_15430	COG0693	protein deglycase activity
D2M30_15435	COG0840	transmembrane signaling receptor activity
D2M30_15440	COG0840	transmembrane signaling receptor activity
D2M30_15445	COG0840	transmembrane signaling receptor activity
D2M30_15450	COG0840	transmembrane signaling receptor activity
D2M30_15465	COG2070	2-Nitropropane dioxygenase
D2M30_15470	COG0432	Pfam Uncharacterised protein family UPF0047
D2M30_15480	COG1253	flavin adenine dinucleotide binding
D2M30_15485	COG2738	Putative neutral zinc metallopeptidase
D2M30_15500	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D2M30_15525	COG1335	isochorismatase
D2M30_15530	COG1979	alcohol dehydrogenase
D2M30_15535	COG1979	alcohol dehydrogenase
D2M30_15540	COG2155	Conserved Protein
D2M30_15545	COG1098	S1 RNA binding domain
D2M30_15550	COG0436	Aminotransferase
D2M30_15555	COG1522	sequence-specific DNA binding
D2M30_15560	COG2267	carboxylic ester hydrolase activity
D2M30_15570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D2M30_15575	COG2205	protein histidine kinase activity
D2M30_15585	COG5018	Exonuclease
D2M30_15590	COG2814	Major facilitator Superfamily
D2M30_15595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2M30_15600	COG3011	Protein conserved in bacteria
D2M30_15610	COG3290	protein histidine kinase activity
D2M30_15615	COG4565	transcriptional regulatory protein
D2M30_15645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D2M30_15645	COG2111	Na H antiporter
D2M30_15650	COG2111	Na H antiporter
D2M30_15655	COG1006	Multisubunit Na H antiporter MnhC subunit
D2M30_15660	COG0651	ATP synthesis coupled electron transport
D2M30_15665	COG1863	multisubunit Na H antiporter MnhE subunit
D2M30_15670	COG2212	antiporter activity
D2M30_15675	COG1320	monovalent cation:proton antiporter activity
D2M30_15680	COG2050	protein possibly involved in aromatic compounds catabolism
D2M30_15685	COG2197	response regulator
D2M30_15690	COG4585	Histidine kinase
D2M30_15700	COG0142	geranyltranstransferase activity
D2M30_15720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D2M30_15725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D2M30_15730	COG1335	isochorismatase
D2M30_15735	COG5506	Protein of unknown function (DUF1694)
D2M30_15750	COG0628	permease
D2M30_15760	COG1418	mRNA catabolic process
D2M30_15765	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_15775	COG1511	domain protein
D2M30_15780	COG0433	COG0433 Predicted ATPase
D2M30_15780	COG1674	ftsk spoiiie
D2M30_15785	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2M30_15790	COG5417	Belongs to the EsaB family
D2M30_15795	COG4842	Belongs to the WXG100 family
D2M30_15800	COG2508	Transcriptional regulator
D2M30_15800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2M30_15805	COG0686	Belongs to the AlaDH PNT family
D2M30_15810	COG5634	Uncharacterized conserved protein (DUF2278)
D2M30_15815	COG3251	PFAM MbtH domain protein
D2M30_15820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2M30_15825	COG3433	isochorismatase activity
D2M30_15825	COG1535	isochorismatase
D2M30_15830	COG1021	2,3-dihydroxybenzoate-AMP ligase
D2M30_15835	COG1169	isochorismate synthase
D2M30_15840	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_15845	COG2819	hydrolase of the alpha beta superfamily
D2M30_15850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2M30_15855	COG1268	BioY protein
D2M30_15860	COG2056	Na+-H+ antiporter family
D2M30_15870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D2M30_15875	COG3584	3D domain protein
D2M30_15890	COG1252	NADH dehydrogenase
D2M30_15915	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D2M30_15920	COG0316	Belongs to the HesB IscA family
D2M30_15930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2M30_15940	COG1252	NADH dehydrogenase
D2M30_15945	COG4837	Protein of unknown function (DUF1462)
D2M30_15950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D2M30_15955	COG1506	peptidase
D2M30_15955	COG4946	Tricorn protease homolog
D2M30_15955	COG0823	Involved in the tonB-independent uptake of proteins
D2M30_15965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D2M30_15970	COG0460	homoserine dehydrogenase
D2M30_15975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2M30_15980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D2M30_15985	COG0647	UMP catabolic process
D2M30_15990	COG2445	Protein of unknown function DUF86
D2M30_15995	COG4470	Protein conserved in bacteria
D2M30_16010	COG0739	heme binding
D2M30_16020	COG0737	Belongs to the 5'-nucleotidase family
D2M30_16025	COG0730	response to heat
D2M30_16030	COG1801	Protein of unknown function DUF72
D2M30_16045	COG2508	Transcriptional regulator
D2M30_16065	COG2814	Major facilitator Superfamily
D2M30_16070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D2M30_16075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2M30_16080	COG2356	endonuclease I
D2M30_16090	COG2188	Transcriptional regulator
D2M30_16095	COG2188	Transcriptional regulator
D2M30_16105	COG0395	ABC-type sugar transport system, permease component
D2M30_16110	COG1175	transmembrane transport
D2M30_16115	COG1653	transport
D2M30_16120	COG2222	sugar isomerase
D2M30_16125	COG0789	Transcriptional regulator
D2M30_16150	COG0322	excinuclease ABC activity
D2M30_16155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2M30_16170	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_16175	COG0719	Fe-S assembly protein
D2M30_16180	COG0822	iron-sulfur transferase activity
D2M30_16185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2M30_16190	COG0719	Fe-S assembly protein
D2M30_16195	COG0396	ATPase activity
D2M30_16210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D2M30_16215	COG1464	Belongs to the NlpA lipoprotein family
D2M30_16220	COG2011	ABC-type metal ion transport system permease component
D2M30_16225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2M30_16235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2M30_16240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2M30_16255	COG1393	Belongs to the ArsC family
D2M30_16260	COG1960	acyl-CoA dehydrogenase activity
D2M30_16265	COG0183	Belongs to the thiolase family
D2M30_16270	COG1024	Enoyl-CoA hydratase
D2M30_16270	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2M30_16290	COG5577	PFAM Coat F domain
D2M30_16295	COG1846	Transcriptional regulator
D2M30_16300	COG0477	Major facilitator Superfamily
D2M30_16305	COG1942	4-Oxalocrotonate Tautomerase
D2M30_16315	COG0583	DNA-binding transcription factor activity
D2M30_16325	COG1120	ATPase activity
D2M30_16340	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_16345	COG0783	Belongs to the Dps family
D2M30_16350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2M30_16355	COG0745	RESPONSE REGULATOR receiver
D2M30_16360	COG2205	protein histidine kinase activity
D2M30_16360	COG2770	Histidine kinase
D2M30_16370	COG1309	transcriptional regulator
D2M30_16375	COG0114	fumarate hydratase activity
D2M30_16385	COG0697	spore germination
D2M30_16390	COG0814	amino acid
D2M30_16400	COG2197	response regulator
D2M30_16405	COG4585	Histidine kinase
D2M30_16410	COG4758	membrane
D2M30_16415	COG3595	metallopeptidase activity
D2M30_16420	COG1842	Phage shock protein A
D2M30_16425	COG4758	membrane
D2M30_16430	COG2814	Major facilitator Superfamily
D2M30_16435	COG2096	Adenosyltransferase
D2M30_16440	COG1120	ATPase activity
D2M30_16445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_16450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2M30_16455	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_16460	COG3386	PFAM SMP-30 Gluconolaconase
D2M30_16465	COG2205	protein histidine kinase activity
D2M30_16470	COG0745	RESPONSE REGULATOR receiver
D2M30_16480	COG1191	sigma factor activity
D2M30_16490	COG2140	Oxalate decarboxylase
D2M30_16500	COG1120	ATPase activity
D2M30_16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_16510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_16515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2M30_16520	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D2M30_16525	COG0531	amino acid
D2M30_16540	COG1988	membrane-bound metal-dependent
D2M30_16545	COG1368	sulfuric ester hydrolase activity
D2M30_16550	COG1910	domain protein
D2M30_16555	COG0725	ABC transporter, periplasmic molybdate-binding protein
D2M30_16560	COG4149	molybdate abc transporter
D2M30_16565	COG2197	response regulator
D2M30_16575	COG1131	(ABC) transporter
D2M30_16585	COG0842	Transport permease protein
D2M30_16590	COG0656	L-ascorbic acid biosynthetic process
D2M30_16610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2M30_16615	COG3973	AAA domain
D2M30_16620	COG2860	membrane
D2M30_16630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D2M30_16635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D2M30_16640	COG2217	Heavy metal translocating P-type atpase
D2M30_16645	COG2217	Heavy metal translocating P-type atpase
D2M30_16650	COG2608	mercury ion transmembrane transporter activity
D2M30_16655	COG1937	Protein conserved in bacteria
D2M30_16660	COG0673	inositol 2-dehydrogenase activity
D2M30_16675	COG2814	Major facilitator Superfamily
D2M30_16690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2M30_16695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D2M30_16700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2M30_16705	COG1126	abc transporter atp-binding protein
D2M30_16710	COG0765	amino acid transport
D2M30_16715	COG0765	amino acid transport
D2M30_16720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_16725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2M30_16730	COG0454	-acetyltransferase
D2M30_16735	COG0583	DNA-binding transcription factor activity
D2M30_16740	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_16745	COG2732	(Barnase) inhibitor
D2M30_16760	COG0557	exoribonuclease II activity
D2M30_16765	COG1647	Serine aminopeptidase, S33
D2M30_16770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D2M30_16775	COG1476	TRANSCRIPTIONal
D2M30_16780	COG1396	sequence-specific DNA binding
D2M30_16785	COG1396	sequence-specific DNA binding
D2M30_16790	COG1733	regulation of RNA biosynthetic process
D2M30_16820	COG1174	glycine betaine transport
D2M30_16825	COG1732	Glycine betaine
D2M30_16830	COG1174	glycine betaine transport
D2M30_16835	COG0517	IMP dehydrogenase activity
D2M30_16835	COG1125	glycine betaine transport
D2M30_16840	COG1510	regulation of RNA biosynthetic process
D2M30_16845	COG1174	glycine betaine transport
D2M30_16850	COG1732	Glycine betaine
D2M30_16855	COG1174	glycine betaine transport
D2M30_16860	COG1125	glycine betaine transport
D2M30_16860	COG0517	IMP dehydrogenase activity
D2M30_16865	COG1510	regulation of RNA biosynthetic process
D2M30_16870	COG2095	MarC family integral membrane protein
D2M30_16875	COG3064	Membrane
D2M30_16880	COG4640	response to antibiotic
D2M30_16885	COG0456	acetyltransferase
D2M30_16900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2M30_16920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2M30_16925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2M30_16935	COG2234	aminopeptidase activity
D2M30_16955	COG0126	phosphoglycerate kinase activity
D2M30_16965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2M30_16970	COG2390	Transcriptional regulator
D2M30_16975	COG2814	Major facilitator Superfamily
D2M30_16980	COG1609	Transcriptional regulator
D2M30_16985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2M30_16995	COG0583	DNA-binding transcription factor activity
D2M30_17000	COG0697	spore germination
D2M30_17005	COG1113	amino acid transport
D2M30_17010	COG1737	Transcriptional regulator
D2M30_17015	COG1070	Carbohydrate kinase
D2M30_17040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2M30_17045	COG2186	Transcriptional regulator
D2M30_17050	COG1620	l-lactate permease
D2M30_17055	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D2M30_17065	COG5039	Polysaccharide pyruvyl transferase
D2M30_17070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2M30_17075	COG0110	maltose O-acetyltransferase activity
D2M30_17080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D2M30_17085	COG2244	polysaccharide biosynthetic process
D2M30_17090	COG1216	Glycosyl transferase, family 2
D2M30_17095	COG5039	Polysaccharide pyruvyl transferase
D2M30_17100	COG1216	Glycosyl transferase, family 2
D2M30_17110	COG0438	transferase activity, transferring glycosyl groups
D2M30_17115	COG1215	transferase activity, transferring glycosyl groups
D2M30_17120	COG0438	transferase activity, transferring glycosyl groups
D2M30_17125	COG1086	Polysaccharide biosynthesis protein
D2M30_17130	COG0489	protein tyrosine kinase activity
D2M30_17135	COG3944	biosynthesis protein
D2M30_17140	COG1396	sequence-specific DNA binding
D2M30_17145	COG2272	Belongs to the type-B carboxylesterase lipase family
D2M30_17155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2M30_17170	COG2364	Membrane
D2M30_17180	COG3479	Phenolic acid decarboxylase
D2M30_17220	COG2211	Major facilitator Superfamily
D2M30_17230	COG1609	Transcriptional regulator
D2M30_17240	COG0583	DNA-binding transcription factor activity
D2M30_17245	COG2828	Protein conserved in bacteria
D2M30_17250	COG2814	Major facilitator Superfamily
D2M30_17250	COG0477	Major facilitator Superfamily
D2M30_17260	COG1611	Belongs to the LOG family
D2M30_17265	COG1694	Mazg nucleotide pyrophosphohydrolase
D2M30_17270	COG0659	secondary active sulfate transmembrane transporter activity
D2M30_17275	COG0288	reversible hydration of carbon dioxide
D2M30_17285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2M30_17290	COG4290	ribonuclease
D2M30_17295	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D2M30_17300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_17310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D2M30_17320	COG1051	belongs to the nudix hydrolase family
D2M30_17325	COG0492	ferredoxin-NADP+ reductase activity
D2M30_17330	COG0791	NLP P60 protein
D2M30_17330	COG3883	PFAM NLP P60 protein
D2M30_17335	COG0457	Tetratricopeptide repeat
D2M30_17340	COG5002	protein histidine kinase activity
D2M30_17345	COG0745	RESPONSE REGULATOR receiver
D2M30_17350	COG1132	(ABC) transporter
D2M30_17355	COG0140	phosphoribosyl-ATP diphosphatase activity
D2M30_17355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D2M30_17380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D2M30_17395	COG4990	cell redox homeostasis
D2M30_17400	COG0110	maltose O-acetyltransferase activity
D2M30_17420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D2M30_17435	COG1309	transcriptional regulator
D2M30_17440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D2M30_17445	COG1950	PFAM Membrane protein of
D2M30_17450	COG1983	PspC domain protein
D2M30_17455	COG3595	metallopeptidase activity
D2M30_17470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D2M30_17480	COG4897	Protein conserved in bacteria
D2M30_17485	COG3848	Pyruvate phosphate dikinase
D2M30_17485	COG0574	Belongs to the PEP-utilizing enzyme family
D2M30_17490	COG1309	transcriptional regulator
D2M30_17495	COG2814	Major facilitator Superfamily
D2M30_17505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2M30_17515	COG3409	Peptidoglycan-binding domain 1 protein
D2M30_17515	COG0793	Belongs to the peptidase S41A family
D2M30_17520	COG3420	alginic acid biosynthetic process
D2M30_17525	COG2177	Part of the ABC transporter FtsEX involved in
D2M30_17530	COG2884	Cell division ATP-binding protein ftsE
D2M30_17535	COG2010	Cytochrome c
D2M30_17540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_17555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D2M30_17570	COG1516	flagellar protein fliS
D2M30_17575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D2M30_17580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2M30_17600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2M30_17605	COG1256	bacterial-type flagellum assembly
D2M30_17605	COG4786	Flagellar basal body rod
D2M30_17610	COG3418	PFAM FlgN family protein
D2M30_17615	COG2747	anti-sigma28 factor FlgM
D2M30_17625	COG1040	competence protein
D2M30_17635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D2M30_17640	COG1307	EDD domain protein, DegV family
D2M30_17645	COG2197	response regulator
D2M30_17650	COG4585	Histidine kinase
D2M30_17655	COG1739	Uncharacterized protein family UPF0029
D2M30_17660	COG1316	TRANSCRIPTIONal
D2M30_17665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2M30_17670	COG0438	transferase activity, transferring glycosyl groups
D2M30_17675	COG1215	transferase activity, transferring glycosyl groups
D2M30_17680	COG3206	protein involved in exopolysaccharide biosynthesis
D2M30_17685	COG3307	-O-antigen
D2M30_17690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D2M30_17695	COG0438	transferase activity, transferring glycosyl groups
D2M30_17695	COG0297	glycogen (starch) synthase activity
D2M30_17700	COG2244	polysaccharide biosynthetic process
D2M30_17710	COG2247	cell wall binding repeat
D2M30_17710	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2M30_17715	COG2247	cell wall binding repeat
D2M30_17715	COG2385	sporulation resulting in formation of a cellular spore
D2M30_17725	COG1316	TRANSCRIPTIONal
D2M30_17730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D2M30_17735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2M30_17740	COG1134	teichoic acid transport
D2M30_17745	COG1682	transport, permease protein
D2M30_17750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2M30_17755	COG0463	Glycosyl transferase, family 2
D2M30_17760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D2M30_17765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D2M30_17770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2M30_17775	COG4193	domain, Protein
D2M30_17780	COG1482	cell wall glycoprotein biosynthetic process
D2M30_17785	COG0697	spore germination
D2M30_17790	COG0814	amino acid
D2M30_17800	COG1215	transferase activity, transferring glycosyl groups
D2M30_17805	COG2814	Major facilitator Superfamily
D2M30_17810	COG1316	TRANSCRIPTIONal
D2M30_17815	COG0561	phosphatase activity
D2M30_17820	COG2433	Pfam Transposase IS66
D2M30_17825	COG0791	NLP P60 protein
D2M30_17840	COG2843	Capsule synthesis protein
D2M30_17850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D2M30_17860	COG0697	spore germination
D2M30_17865	COG0814	amino acid
D2M30_17875	COG1609	Transcriptional regulator
D2M30_17880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2M30_17890	COG1129	ABC transporter
D2M30_17895	COG1172	Belongs to the binding-protein-dependent transport system permease family
D2M30_17900	COG1879	ABC-type sugar transport system periplasmic component
D2M30_17905	COG3103	Sh3 type 3 domain protein
D2M30_17910	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2M30_17915	COG3527	Alpha-acetolactate decarboxylase
D2M30_17920	COG0028	Belongs to the TPP enzyme family
D2M30_17925	COG0583	DNA-binding transcription factor activity
D2M30_17930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D2M30_17945	COG5337	Spore coat protein CotH
D2M30_17955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D2M30_17965	COG0405	Gamma-glutamyltransferase
D2M30_17970	COG1522	sequence-specific DNA binding
D2M30_17975	COG2059	Chromate
D2M30_17980	COG2059	Chromate
D2M30_17995	COG5444	nuclease activity
D2M30_18010	COG3878	Protein conserved in bacteria
D2M30_18015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D2M30_18020	COG4464	protein tyrosine phosphatase activity
D2M30_18025	COG0489	protein tyrosine kinase activity
D2M30_18030	COG3944	biosynthesis protein
D2M30_18045	COG4715	Zinc finger, swim domain protein
D2M30_18050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2M30_18055	COG0561	phosphatase activity
D2M30_18060	COG1349	DNA-binding transcription factor activity
D2M30_18065	COG0629	single-stranded DNA binding
D2M30_18090	COG0457	Tetratricopeptide repeat
D2M30_18095	COG4786	Flagellar basal body rod
D2M30_18100	COG4786	Flagellar basal body rod
D2M30_18105	COG1077	Cell shape determining protein MreB Mrl
D2M30_18115	COG1846	Transcriptional regulator
D2M30_18120	COG2814	Major facilitator Superfamily
D2M30_18125	COG1953	Uracil, thiamine, allantoin
D2M30_18130	COG0477	Major facilitator Superfamily
D2M30_18135	COG1335	isochorismatase
D2M30_18140	COG0004	ammonium transporteR
D2M30_18145	COG0347	Belongs to the P(II) protein family
D2M30_18150	COG0772	Belongs to the SEDS family
D2M30_18155	COG0671	phosphoesterase, PA-phosphatase related
D2M30_18175	COG0739	heme binding
D2M30_18180	COG1247	-acetyltransferase
D2M30_18195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2M30_18205	COG2910	NAD(P)H-binding
D2M30_18210	COG1959	2 iron, 2 sulfur cluster binding
D2M30_18225	COG0831	urea catabolic process
D2M30_18230	COG3237	CsbD-like
D2M30_18235	COG1994	Peptidase M50
D2M30_18240	COG0457	Tetratricopeptide repeat
D2M30_18250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D2M30_18255	COG2304	oxidoreductase activity
D2M30_18260	COG2304	oxidoreductase activity
D2M30_18265	COG2385	sporulation resulting in formation of a cellular spore
D2M30_18270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2M30_18280	COG4836	Membrane
D2M30_18320	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D2M30_18350	COG0698	ribose 5-phosphate isomerase
D2M30_18355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2M30_18365	COG0009	L-threonylcarbamoyladenylate synthase
D2M30_18370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D2M30_18390	COG2890	protein-(glutamine-N5) methyltransferase activity
D2M30_18395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D2M30_18400	COG0346	lactoylglutathione lyase activity
D2M30_18405	COG0789	Transcriptional regulator
D2M30_18410	COG0679	Auxin Efflux Carrier
D2M30_18415	COG0281	malic enzyme
D2M30_18425	COG0254	rRNA binding
D2M30_18430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D2M30_18435	COG1494	fructose-1,6-bisphosphatase
D2M30_18440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2M30_18450	COG0191	fructose-bisphosphate aldolase activity
D2M30_18455	COG2204	response regulator
D2M30_18460	COG4821	SIS domain
D2M30_18475	COG2181	nitrate reductase activity
D2M30_18475	COG0247	lactate metabolic process
D2M30_18480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2M30_18495	COG1132	(ABC) transporter
D2M30_18505	COG2181	nitrate reductase activity
D2M30_18510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D2M30_18515	COG1140	nitrate reductase beta subunit
D2M30_18525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2M30_18535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2M30_18540	COG2223	nitrite transmembrane transporter activity
D2M30_18550	COG4506	Protein conserved in bacteria
D2M30_18560	COG3391	amine dehydrogenase activity
D2M30_18570	COG0457	Tetratricopeptide repeat
D2M30_18580	COG0010	Belongs to the arginase family
D2M30_18585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D2M30_18590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2M30_18605	COG1994	Peptidase M50
D2M30_18610	COG1942	4-Oxalocrotonate Tautomerase
D2M30_18615	COG1846	Transcriptional regulator
D2M30_18625	COG0531	amino acid
D2M30_18630	COG3465	dGTPase activity
D2M30_18635	COG1078	dGTPase activity
D2M30_18650	COG1695	Transcriptional regulator
D2M30_18660	COG1131	(ABC) transporter
D2M30_18665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2M30_18695	COG0583	DNA-binding transcription factor activity
D2M30_18700	COG2855	membrane
D2M30_18705	COG0280	phosphate acetyltransferase
D2M30_18715	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_18720	COG0436	Aminotransferase
D2M30_18730	COG0151	Belongs to the GarS family
D2M30_18740	COG1917	Cupin 2, conserved barrel domain protein
D2M30_18745	COG0077	Prephenate dehydratase
D2M30_18750	COG2814	Major facilitator Superfamily
D2M30_18755	COG2814	Major facilitator Superfamily
D2M30_18760	COG0833	amino acid
D2M30_18765	COG4187	Peptidase family M20/M25/M40
D2M30_18775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2M30_18785	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D2M30_18790	COG1091	dTDP-4-dehydrorhamnose reductase activity
D2M30_18795	COG1088	dTDP-glucose 4,6-dehydratase activity
D2M30_18800	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D2M30_18805	COG3980	spore coat polysaccharide biosynthesis protein
D2M30_18810	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D2M30_18815	COG2089	acid synthase
D2M30_18820	COG0456	acetyltransferase
D2M30_18825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2M30_18830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2M30_18835	COG0463	Glycosyl transferase, family 2
D2M30_18845	COG2363	Small membrane protein
D2M30_18850	COG2233	PERMEase
D2M30_18865	COG1216	Glycosyl transferase, family 2
D2M30_18875	COG0351	phosphomethylpyrimidine kinase
D2M30_18885	COG1621	beta-fructofuranosidase activity
D2M30_18890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_18890	COG1263	PTS System
D2M30_18895	COG3711	transcriptional antiterminator
D2M30_18905	COG1404	Belongs to the peptidase S8 family
D2M30_18910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2M30_18915	COG2378	regulation of single-species biofilm formation
D2M30_18935	COG0778	Nitroreductase
D2M30_18940	COG0772	Belongs to the SEDS family
D2M30_18945	COG0454	-acetyltransferase
D2M30_18965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2M30_18970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2M30_18975	COG2261	transglycosylase associated protein
D2M30_18980	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D2M30_18985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D2M30_18990	COG2246	polysaccharide biosynthetic process
D2M30_18995	COG1309	transcriptional regulator
D2M30_19015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D2M30_19020	COG2837	iron assimilation
D2M30_19025	COG2822	iron ion transport
D2M30_19030	COG0672	)-iron permease
D2M30_19045	COG0583	DNA-binding transcription factor activity
D2M30_19055	COG1346	cytolysis
D2M30_19060	COG4895	conserved protein (DUF2196)
D2M30_19065	COG0789	Transcriptional regulator
D2M30_19070	COG5504	Zn-dependent protease
D2M30_19085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D2M30_19090	COG0346	lactoylglutathione lyase activity
D2M30_19095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_19100	COG1404	Belongs to the peptidase S8 family
D2M30_19105	COG1442	glycosyl transferase family 8
D2M30_19110	COG2357	RelA SpoT domain protein
D2M30_19115	COG1575	Belongs to the MenA family. Type 1 subfamily
D2M30_19135	COG1696	Membrane protein involved in D-alanine export
D2M30_19145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D2M30_19150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2M30_19155	COG1486	melibiose metabolic process
D2M30_19160	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2M30_19165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_19170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_19175	COG3711	transcriptional antiterminator
D2M30_19175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2M30_19190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_19195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2M30_19205	COG0640	Transcriptional regulator
D2M30_19210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D2M30_19215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_19220	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2M30_19225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2M30_19230	COG2723	6-phospho-beta-galactosidase activity
D2M30_19235	COG1940	carbohydrate kinase activity
D2M30_19240	COG1482	cell wall glycoprotein biosynthetic process
D2M30_19250	COG0753	catalase activity
D2M30_19255	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D2M30_19260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D2M30_19265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D2M30_19270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D2M30_19275	COG4988	ABC transporter
D2M30_19280	COG1294	oxidase, subunit
D2M30_19285	COG1271	oxidase subunit
D2M30_19290	COG3493	citrate carrier protein
D2M30_19295	COG0726	polysaccharide deacetylase
D2M30_19300	COG3842	ATPase activity
D2M30_19305	COG2508	Transcriptional regulator
D2M30_19310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_19320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2M30_19330	COG4894	glucomannan catabolic process
D2M30_19335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2M30_19340	COG0500	methyltransferase
D2M30_19345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2M30_19360	COG0693	protein deglycase activity
D2M30_19360	COG0753	catalase activity
D2M30_19365	COG2851	Citrate transporter
D2M30_19370	COG2273	Hydrolase Family 16
D2M30_19375	COG3711	transcriptional antiterminator
D2M30_19380	COG2270	Major facilitator Superfamily
D2M30_19385	COG0513	Belongs to the DEAD box helicase family
D2M30_19470	COG3209	COG3209 Rhs family protein
D2M30_19480	COG0697	spore germination
D2M30_19485	COG0589	response to stress
D2M30_19490	COG2723	6-phospho-beta-galactosidase activity
D2M30_19495	COG1263	PTS System
D2M30_19495	COG2190	(PTS) system
D2M30_19495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2M30_19505	COG0494	nUDIX hydrolase
D2M30_19510	COG3507	Belongs to the glycosyl hydrolase 43 family
D2M30_19540	COG0010	Belongs to the arginase family
D2M30_19545	COG0833	amino acid
D2M30_19550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D2M30_19555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2M30_19565	COG2390	Transcriptional regulator
D2M30_19570	COG0561	phosphatase activity
D2M30_19600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2M30_19605	COG5294	Protein conserved in bacteria
D2M30_19610	COG0577	efflux transmembrane transporter activity
D2M30_19615	COG1136	(ABC) transporter
D2M30_19620	COG2205	protein histidine kinase activity
D2M30_19625	COG0745	RESPONSE REGULATOR receiver
D2M30_19640	COG1082	Xylose isomerase domain protein TIM barrel
D2M30_19650	COG2814	Major facilitator Superfamily
D2M30_19680	COG1349	DNA-binding transcription factor activity
D2M30_19685	COG0667	Aldo Keto reductase
D2M30_19690	COG2814	Major facilitator Superfamily
D2M30_19700	COG1028	Short-chain dehydrogenase reductase Sdr
D2M30_19705	COG2197	response regulator
D2M30_19710	COG4585	Histidine kinase
D2M30_19715	COG3239	Fatty acid desaturase
D2M30_19720	COG1309	transcriptional regulator
D2M30_19725	COG1012	belongs to the aldehyde dehydrogenase family
D2M30_19730	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D2M30_19740	COG0640	Transcriptional regulator
D2M30_19745	COG2814	Major facilitator Superfamily
D2M30_19750	COG1714	RDD family
D2M30_19760	COG0450	alkyl hydroperoxide reductase
D2M30_19765	COG3634	alkyl hydroperoxide reductase activity
D2M30_19775	COG1113	amino acid transport
D2M30_19800	COG2080	2 iron, 2 sulfur cluster binding
D2M30_19815	COG2068	MobA-Related Protein
D2M30_19820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D2M30_19870	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
D2M30_19875	COG0667	Aldo Keto reductase
D2M30_19880	COG0456	acetyltransferase
D2M30_19885	COG0457	Tetratricopeptide repeat
D2M30_19890	COG0010	Belongs to the arginase family
D2M30_19895	COG0833	amino acid
D2M30_19900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2M30_19905	COG5658	integral membrane protein
D2M30_19910	COG0640	Transcriptional regulator
D2M30_19915	COG3829	transcription factor binding
D2M30_19925	COG0488	(ABC) transporter
D2M30_19940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2M30_19945	COG3850	Histidine kinase
D2M30_19945	COG5002	protein histidine kinase activity
D2M30_19950	COG0745	RESPONSE REGULATOR receiver
D2M30_19960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2M30_19965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D2M30_19970	COG4853	Protein conserved in bacteria
D2M30_19975	COG4863	YycH protein
D2M30_19980	COG5002	protein histidine kinase activity
D2M30_19985	COG0745	RESPONSE REGULATOR receiver
D2M30_20020	COG0346	lactoylglutathione lyase activity
D2M30_20025	COG0305	Participates in initiation and elongation during chromosome replication
D2M30_20040	COG3093	addiction module antidote protein HigA
D2M30_20065	COG0438	transferase activity, transferring glycosyl groups
D2M30_20085	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D2M30_20090	COG4241	membrane
D2M30_20100	COG5577	PFAM Coat F domain
D2M30_20105	COG1733	regulation of RNA biosynthetic process
D2M30_20115	COG0697	spore germination
D2M30_20120	COG1621	beta-fructofuranosidase activity
D2M30_20125	COG1621	beta-fructofuranosidase activity
D2M30_20130	COG1802	Transcriptional regulator
D2M30_20135	COG2318	DinB family
D2M30_20140	COG2211	Major facilitator Superfamily
D2M30_20155	COG0778	Nitroreductase
D2M30_20160	COG1846	Transcriptional regulator
D2M30_20165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2M30_20170	COG1846	Transcriptional regulator
D2M30_20175	COG2153	protein acetylation
D2M30_20180	COG0640	Transcriptional regulator
D2M30_20185	COG2267	carboxylic ester hydrolase activity
D2M30_20190	COG1331	Highly conserved protein containing a thioredoxin domain
D2M30_20195	COG0477	Major facilitator Superfamily
D2M30_20210	COG0457	Tetratricopeptide repeat
D2M30_20240	COG0741	lytic transglycosylase activity
D2M30_20240	COG0791	NLP P60 protein
D2M30_20245	COG5644	endopeptidase inhibitor activity
D2M30_20255	COG0433	COG0433 Predicted ATPase
D2M30_20305	COG2946	Replication initiation factor
D2M30_20310	COG1674	ftsk spoiiie
D2M30_20335	COG1396	sequence-specific DNA binding
D2M30_20340	COG2856	Zn peptidase
D2M30_20355	COG1331	Highly conserved protein containing a thioredoxin domain
D2M30_20360	COG1331	Highly conserved protein containing a thioredoxin domain
D2M30_20365	COG1266	CAAX protease self-immunity
D2M30_20370	COG0477	Major facilitator Superfamily
D2M30_20370	COG2814	Major facilitator Superfamily
D2M30_20375	COG0346	lactoylglutathione lyase activity
D2M30_20380	COG1609	Transcriptional regulator
D2M30_20385	COG0708	Exodeoxyribonuclease III
D2M30_20390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2M30_20395	COG2169	Transcriptional regulator
D2M30_20405	COG0629	single-stranded DNA binding
D2M30_20415	COG0012	GTP binding
D2M30_20420	COG0243	molybdopterin cofactor binding
D2M30_20425	COG4481	Protein conserved in bacteria
D2M30_20430	COG3949	Membrane
D2M30_20445	COG1475	DNA binding
D2M30_20450	COG1192	Involved in chromosome partitioning
D2M30_20475	COG1847	R3H domain protein
D2M30_20480	COG0706	membrane insertase activity
D2M30_20490	COG0230	Belongs to the bacterial ribosomal protein bL34 family