locus-tag	class	description
F5K02_00010	COG0592	DNA-directed DNA polymerase activity
F5K02_00015	COG2501	S4 domain
F5K02_00030	COG0187	DNA topoisomerase II activity
F5K02_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F5K02_00070	COG0516	GMP reductase activity
F5K02_00070	COG0517	IMP dehydrogenase activity
F5K02_00075	COG1686	Belongs to the peptidase S11 family
F5K02_00095	COG1929	Belongs to the glycerate kinase type-1 family
F5K02_00105	COG1428	Deoxynucleoside kinase
F5K02_00110	COG1428	Deoxynucleoside kinase
F5K02_00115	COG1388	LysM domain
F5K02_00115	COG3858	chitin binding
F5K02_00120	COG1335	isochorismatase
F5K02_00125	COG0590	tRNA wobble adenosine to inosine editing
F5K02_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F5K02_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F5K02_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F5K02_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
F5K02_00195	COG3853	Toxic anion resistance protein (TelA)
F5K02_00200	COG1982	Orn Lys Arg decarboxylase major
F5K02_00210	COG3870	Protein conserved in bacteria
F5K02_00215	COG1728	Protein conserved in bacteria
F5K02_00220	COG0470	DNA polymerase III
F5K02_00225	COG1774	PSP1 C-terminal conserved region
F5K02_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F5K02_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F5K02_00250	COG2002	toxin-antitoxin pair type II binding
F5K02_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5K02_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5K02_00260	COG0084	hydrolase, TatD family'
F5K02_00265	COG3583	domain protein
F5K02_00265	COG3584	3D domain protein
F5K02_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F5K02_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F5K02_00285	COG4466	Protein conserved in bacteria
F5K02_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F5K02_00305	COG0251	oxidation-reduction process
F5K02_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F5K02_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F5K02_00345	COG2002	toxin-antitoxin pair type II binding
F5K02_00350	COG2244	polysaccharide biosynthetic process
F5K02_00355	COG3956	TIGRFAM MazG family protein
F5K02_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F5K02_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F5K02_00380	COG1098	S1 RNA binding domain
F5K02_00395	COG2208	phosphoserine phosphatase activity
F5K02_00400	COG2304	oxidoreductase activity
F5K02_00405	COG0515	serine threonine protein kinase
F5K02_00410	COG0037	tRNA processing
F5K02_00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F5K02_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F5K02_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F5K02_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F5K02_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F5K02_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
F5K02_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F5K02_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F5K02_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F5K02_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F5K02_00475	COG1396	sequence-specific DNA binding
F5K02_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F5K02_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F5K02_00565	COG4463	regulation of RNA biosynthetic process
F5K02_00570	COG3880	PFAM UvrB UvrC protein
F5K02_00580	COG0542	response to heat
F5K02_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F5K02_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F5K02_00595	COG4956	integral membrane protein (PIN domain superfamily)
F5K02_00615	COG1045	serine acetyltransferase
F5K02_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F5K02_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F5K02_00635	COG3688	RNA-binding protein containing a PIN domain
F5K02_00640	COG1595	DNA-templated transcription, initiation
F5K02_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F5K02_00655	COG0250	Participates in transcription elongation, termination and antitermination
F5K02_00680	COG2813	Specifically methylates the guanine in position
F5K02_00695	COG1358	cellular component organization or biogenesis
F5K02_00720	COG0596	Alpha beta hydrolase
F5K02_00830	COG0201	protein transport
F5K02_00840	COG0024	Methionine aminopeptidase
F5K02_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F5K02_00880	COG1122	ATPase activity
F5K02_00885	COG1122	ATPase activity
F5K02_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F5K02_00910	COG2226	methyltransferase
F5K02_00915	COG2318	DinB family
F5K02_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_00930	COG0489	protein tyrosine kinase activity
F5K02_00940	COG2194	sulfuric ester hydrolase activity
F5K02_00945	COG0726	polysaccharide deacetylase
F5K02_01005	COG0738	Major facilitator superfamily
F5K02_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F5K02_01025	COG0659	secondary active sulfate transmembrane transporter activity
F5K02_01030	COG0385	Bile acid
F5K02_01035	COG2819	hydrolase of the alpha beta superfamily
F5K02_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F5K02_01055	COG2207	Transcriptional regulator
F5K02_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F5K02_01060	COG3876	Protein conserved in bacteria
F5K02_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
F5K02_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F5K02_01075	COG1263	PTS System
F5K02_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F5K02_01090	COG1683	Conserved Protein
F5K02_01120	COG1595	DNA-templated transcription, initiation
F5K02_01125	COG5662	AntiSigma factor
F5K02_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F5K02_01135	COG4856	YbbR-like protein
F5K02_01175	COG1346	cytolysis
F5K02_01180	COG1380	Effector of murein hydrolase LrgA
F5K02_01185	COG1846	Transcriptional regulator
F5K02_01190	COG1113	amino acid transport
F5K02_01195	COG1011	Hydrolase
F5K02_01200	COG4585	Histidine kinase
F5K02_01205	COG2197	response regulator
F5K02_01210	COG1131	(ABC) transporter
F5K02_01230	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F5K02_01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_01250	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_01250	COG3321	synthase
F5K02_01250	COG4221	oxidoreductase activity
F5K02_01255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_01255	COG0300	oxidoreductase activity
F5K02_01255	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_01255	COG3321	synthase
F5K02_01255	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_01295	COG0531	amino acid
F5K02_01305	COG0584	glycerophosphoryl diester phosphodiesterase
F5K02_01310	COG2271	Major facilitator Superfamily
F5K02_01325	COG2368	4-hydroxyphenylacetate
F5K02_01335	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_01350	COG0371	Dehydrogenase
F5K02_01360	COG1183	phosphatidylcholine synthase activity
F5K02_01365	COG0586	Pfam SNARE associated Golgi protein
F5K02_01370	COG0688	phosphatidylethanolamine metabolic process
F5K02_01385	COG1301	dicarboxylic acid transport
F5K02_01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F5K02_01395	COG0833	amino acid
F5K02_01400	COG2040	homocysteine
F5K02_01405	COG1115	amino acid carrier protein
F5K02_01410	COG2066	Belongs to the glutaminase family
F5K02_01415	COG4191	Histidine kinase
F5K02_01420	COG0784	Response regulator, receiver
F5K02_01425	COG3173	Aminoglycoside phosphotransferase
F5K02_01440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F5K02_01445	COG0778	Nitroreductase
F5K02_01450	COG0346	lactoylglutathione lyase activity
F5K02_01455	COG2259	Doxx family
F5K02_01460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_01475	COG3773	Cell wall hydrolase
F5K02_01485	COG3540	Alkaline phosphatase
F5K02_01490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F5K02_01495	COG0805	protein transport
F5K02_01505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F5K02_01510	COG0477	Major facilitator Superfamily
F5K02_01515	COG1309	transcriptional regulator
F5K02_01520	COG0252	asparaginase activity
F5K02_01525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F5K02_01530	COG3012	SEC-C Motif Domain Protein
F5K02_01530	COG1405	negative regulation of cell septum assembly
F5K02_01535	COG0667	Aldo Keto reductase
F5K02_01545	COG1595	DNA-templated transcription, initiation
F5K02_01550	COG1595	DNA-templated transcription, initiation
F5K02_01555	COG1876	peptidase activity
F5K02_01560	COG0457	Tetratricopeptide repeat
F5K02_01565	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_01570	COG0366	Alpha amylase catalytic
F5K02_01575	COG0803	Belongs to the bacterial solute-binding protein 9 family
F5K02_01580	COG1121	(ABC) transporter
F5K02_01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F5K02_01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_01595	COG2310	stress, protein
F5K02_01600	COG2310	stress, protein
F5K02_01605	COG2310	stress, protein
F5K02_01610	COG0861	Integral membrane protein TerC family
F5K02_01620	COG3853	Toxic anion resistance protein (TelA)
F5K02_01625	COG0477	Major facilitator Superfamily
F5K02_01630	COG4175	Glycine betaine
F5K02_01630	COG0517	IMP dehydrogenase activity
F5K02_01635	COG4176	ABC-type proline glycine betaine transport system permease component
F5K02_01640	COG2113	Glycine betaine
F5K02_01645	COG1473	amidohydrolase
F5K02_01650	COG1288	antiporter activity
F5K02_01660	COG0366	Alpha amylase catalytic
F5K02_01670	COG2814	Major facilitator Superfamily
F5K02_01675	COG1846	Transcriptional regulator
F5K02_01680	COG1280	lysine exporter protein (LysE YggA)
F5K02_01685	COG3403	YqcI/YcgG family
F5K02_01690	COG1113	amino acid transport
F5K02_01695	COG3665	Urea carboxylase-associated protein
F5K02_01710	COG1660	Displays ATPase and GTPase activities
F5K02_01715	COG1082	Xylose isomerase domain protein TIM barrel
F5K02_01720	COG2271	Major facilitator Superfamily
F5K02_01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F5K02_01735	COG3458	cephalosporin-C deacetylase activity
F5K02_01740	COG3541	Predicted nucleotidyltransferase
F5K02_01745	COG0506	proline dehydrogenase activity
F5K02_01750	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_01755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F5K02_01760	COG2508	Transcriptional regulator
F5K02_01770	COG1587	Uroporphyrinogen-III synthase
F5K02_01770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F5K02_01775	COG2146	nitrite reductase [NAD(P)H] activity
F5K02_01780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F5K02_01785	COG0243	molybdopterin cofactor binding
F5K02_01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F5K02_01795	COG2223	nitrite transmembrane transporter activity
F5K02_01800	COG0523	cobalamin synthesis protein
F5K02_01805	COG1063	alcohol dehydrogenase
F5K02_01810	COG1714	RDD family
F5K02_01820	COG2723	6-phospho-beta-galactosidase activity
F5K02_01830	COG3209	COG3209 Rhs family protein
F5K02_01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F5K02_01840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F5K02_01845	COG1733	regulation of RNA biosynthetic process
F5K02_01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_01860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_01865	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F5K02_01880	COG0697	spore germination
F5K02_01885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_01895	COG2364	Membrane
F5K02_01900	COG1126	abc transporter atp-binding protein
F5K02_01905	COG0765	amino acid transport
F5K02_01910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_01915	COG0583	DNA-binding transcription factor activity
F5K02_01920	COG0163	prenyltransferase activity
F5K02_01925	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F5K02_01940	COG3104	oligopeptide transport
F5K02_01945	COG5434	Belongs to the glycosyl hydrolase 28 family
F5K02_01955	COG0697	spore germination
F5K02_01965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F5K02_01970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_01975	COG0456	acetyltransferase
F5K02_01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_01985	COG0765	amino acid transport
F5K02_01990	COG1126	abc transporter atp-binding protein
F5K02_01995	COG1473	amidohydrolase
F5K02_02000	COG2079	MmgE PrpD family protein
F5K02_02005	COG1136	(ABC) transporter
F5K02_02010	COG0577	efflux transmembrane transporter activity
F5K02_02015	COG0745	RESPONSE REGULATOR receiver
F5K02_02020	COG5002	protein histidine kinase activity
F5K02_02020	COG3850	Histidine kinase
F5K02_02025	COG0457	Tetratricopeptide repeat
F5K02_02040	COG0527	aspartate kinase activity
F5K02_02045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_02050	COG4605	iron ion homeostasis
F5K02_02055	COG4604	ABC transporter, ATP-binding protein
F5K02_02060	COG4607	ABC-type enterochelin transport system periplasmic component
F5K02_02065	COG2814	Major facilitator Superfamily
F5K02_02070	COG1309	transcriptional regulator
F5K02_02075	COG0778	Nitroreductase
F5K02_02080	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F5K02_02085	COG0640	Transcriptional regulator
F5K02_02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_02095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F5K02_02100	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_02105	COG4975	Glucose uptake
F5K02_02110	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_02115	COG4549	nuclear export factor GLE1
F5K02_02120	COG1276	copper resistance
F5K02_02120	COG2372	response to copper ion
F5K02_02125	COG1349	DNA-binding transcription factor activity
F5K02_02135	COG2213	PTS system mannitol-specific
F5K02_02140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_02150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F5K02_02160	COG0561	phosphatase activity
F5K02_02170	COG1914	H( )-stimulated, divalent metal cation uptake system
F5K02_02180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F5K02_02185	COG1984	allophanate hydrolase subunit 2
F5K02_02190	COG1414	Transcriptional regulator
F5K02_02195	COG2755	lipolytic protein G-D-S-L family
F5K02_02205	COG2329	Antibiotic biosynthesis monooxygenase
F5K02_02210	COG0768	penicillin binding
F5K02_02215	COG4989	oxidoreductase activity
F5K02_02220	COG3711	transcriptional antiterminator
F5K02_02225	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_02230	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_02235	COG1917	Cupin 2, conserved barrel domain protein
F5K02_02240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F5K02_02245	COG3871	stress protein (general stress protein 26)
F5K02_02260	COG2814	Major facilitator Superfamily
F5K02_02265	COG1522	sequence-specific DNA binding
F5K02_02270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F5K02_02270	COG0551	DNA topoisomerase type I activity
F5K02_02275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F5K02_02280	COG3706	GGDEF domain
F5K02_02285	COG5298	Protein conserved in bacteria
F5K02_02290	COG1215	transferase activity, transferring glycosyl groups
F5K02_02300	COG0531	amino acid
F5K02_02310	COG0028	Belongs to the TPP enzyme family
F5K02_02335	COG0457	Tetratricopeptide repeat
F5K02_02365	COG1914	H( )-stimulated, divalent metal cation uptake system
F5K02_02380	COG4876	unkown
F5K02_02390	COG2076	Multidrug Resistance protein
F5K02_02395	COG2217	Heavy metal translocating P-type atpase
F5K02_02400	COG3729	General stress protein
F5K02_02410	COG2329	Antibiotic biosynthesis monooxygenase
F5K02_02415	COG3546	catalase activity
F5K02_02420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F5K02_02425	COG3290	protein histidine kinase activity
F5K02_02430	COG4565	transcriptional regulatory protein
F5K02_02435	COG1301	dicarboxylic acid transport
F5K02_02440	COG0628	permease
F5K02_02445	COG1131	(ABC) transporter
F5K02_02450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F5K02_02460	COG1960	acyl-CoA dehydrogenase activity
F5K02_02475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F5K02_02480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_02490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F5K02_02495	COG0513	Belongs to the DEAD box helicase family
F5K02_02500	COG3402	PFAM membrane-flanked domain
F5K02_02505	COG3428	Bacterial PH domain
F5K02_02510	COG0705	Rhomboid family
F5K02_02520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F5K02_02525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F5K02_02530	COG0864	Transcriptional regulator
F5K02_02535	COG2337	Toxic component of a toxin-antitoxin (TA) module
F5K02_02540	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_02545	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_02550	COG2172	sigma factor antagonist activity
F5K02_02555	COG2208	phosphoserine phosphatase activity
F5K02_02560	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_02570	COG1191	sigma factor activity
F5K02_02575	COG2208	phosphoserine phosphatase activity
F5K02_02580	COG2183	response to ionizing radiation
F5K02_02630	COG2249	NAD(P)H dehydrogenase (quinone) activity
F5K02_02640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F5K02_02645	COG1522	sequence-specific DNA binding
F5K02_02670	COG0477	Major facilitator Superfamily
F5K02_02675	COG1846	Transcriptional regulator
F5K02_02685	COG2030	dehydratase
F5K02_02700	COG1959	2 iron, 2 sulfur cluster binding
F5K02_02705	COG2910	NAD(P)H-binding
F5K02_02715	COG3239	Fatty acid desaturase
F5K02_02725	COG1278	Cold shock
F5K02_02730	COG1329	Transcriptional regulator
F5K02_02735	COG1794	racemase activity, acting on amino acids and derivatives
F5K02_02750	COG3621	Patatin-like phospholipase
F5K02_02775	COG0277	FAD linked oxidase domain protein
F5K02_02800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F5K02_02835	COG0351	phosphomethylpyrimidine kinase
F5K02_02855	COG1064	alcohol dehydrogenase
F5K02_02860	COG0789	Transcriptional regulator
F5K02_02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_02885	COG2814	Major facilitator Superfamily
F5K02_02890	COG1309	transcriptional regulator
F5K02_02895	COG0697	spore germination
F5K02_02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_02905	COG5577	PFAM Coat F domain
F5K02_02915	COG1063	alcohol dehydrogenase
F5K02_02920	COG5577	PFAM Coat F domain
F5K02_02930	COG4585	Histidine kinase
F5K02_02935	COG2197	response regulator
F5K02_02940	COG2409	Drug exporters of the RND superfamily
F5K02_02945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F5K02_02950	COG0488	(ABC) transporter
F5K02_02955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F5K02_02960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_02970	COG2814	Major facilitator Superfamily
F5K02_02975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F5K02_02985	COG0730	response to heat
F5K02_02990	COG0456	acetyltransferase
F5K02_03000	COG1051	belongs to the nudix hydrolase family
F5K02_03005	COG2226	methyltransferase
F5K02_03010	COG0473	3-isopropylmalate dehydrogenase activity
F5K02_03015	COG1802	Transcriptional regulator
F5K02_03020	COG1819	glycosyl
F5K02_03035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F5K02_03040	COG1388	LysM domain
F5K02_03045	COG2814	Major facilitator Superfamily
F5K02_03050	COG2188	Transcriptional regulator
F5K02_03055	COG2186	Transcriptional regulator
F5K02_03060	COG2807	transmembrane transport
F5K02_03065	COG2076	Multidrug Resistance protein
F5K02_03070	COG2076	Multidrug Resistance protein
F5K02_03075	COG1309	transcriptional regulator
F5K02_03080	COG0531	amino acid
F5K02_03090	COG3832	glyoxalase III activity
F5K02_03095	COG0604	alcohol dehydrogenase
F5K02_03100	COG2814	Major facilitator Superfamily
F5K02_03140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F5K02_03145	COG0802	atpase or kinase
F5K02_03150	COG1214	PFAM Peptidase M22, glycoprotease
F5K02_03155	COG0456	acetyltransferase
F5K02_03160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F5K02_03165	COG0488	(ABC) transporter
F5K02_03180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F5K02_03185	COG0805	protein transport
F5K02_03195	COG1266	CAAX protease self-immunity
F5K02_03215	COG2856	Zn peptidase
F5K02_03225	COG3620	sequence-specific DNA binding
F5K02_03230	COG1476	TRANSCRIPTIONal
F5K02_03280	COG3935	DnaD domain protein
F5K02_03285	COG1484	DNA-dependent DNA replication
F5K02_03370	COG1595	DNA-templated transcription, initiation
F5K02_03555	COG0745	RESPONSE REGULATOR receiver
F5K02_03570	COG3290	protein histidine kinase activity
F5K02_03650	COG0457	Tetratricopeptide repeat
F5K02_03655	COG1063	alcohol dehydrogenase
F5K02_03660	COG2211	Major facilitator Superfamily
F5K02_03665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F5K02_03675	COG1842	Phage shock protein A
F5K02_03680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F5K02_03685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F5K02_03690	COG4260	virion core protein, lumpy skin disease virus
F5K02_03695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
F5K02_03695	COG2755	lipolytic protein G-D-S-L family
F5K02_03705	COG1595	DNA-templated transcription, initiation
F5K02_03710	COG1063	alcohol dehydrogenase
F5K02_03715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F5K02_03720	COG0823	Involved in the tonB-independent uptake of proteins
F5K02_03730	COG2132	Multicopper oxidase
F5K02_03735	COG1113	amino acid transport
F5K02_03740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F5K02_03745	COG0714	Associated with various cellular activities
F5K02_03750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
F5K02_03755	COG1305	Transglutaminase-like
F5K02_03780	COG2252	PERMEase
F5K02_03785	COG3064	Membrane
F5K02_03805	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F5K02_03810	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F5K02_03815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F5K02_03820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F5K02_03825	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F5K02_03840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F5K02_03850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F5K02_03855	COG0138	bifunctional purine biosynthesis protein purh
F5K02_03860	COG0151	Belongs to the GarS family
F5K02_03870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F5K02_03875	COG1470	cell adhesion involved in biofilm formation
F5K02_03880	COG4496	protein, YerC YecD
F5K02_03885	COG0069	glutamate synthase activity
F5K02_03895	COG0210	DNA helicase
F5K02_03905	COG4851	CamS sex pheromone cAM373 precursor
F5K02_03910	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F5K02_03915	COG1285	pathogenesis
F5K02_03920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F5K02_03940	COG1309	transcriptional regulator
F5K02_03945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F5K02_03950	COG1597	lipid kinase activity
F5K02_03955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F5K02_04005	COG5444	nuclease activity
F5K02_04030	COG3546	catalase activity
F5K02_04035	COG0454	-acetyltransferase
F5K02_04045	COG2323	membrane
F5K02_04050	COG2329	Antibiotic biosynthesis monooxygenase
F5K02_04055	COG0346	lactoylglutathione lyase activity
F5K02_04065	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_04070	COG5583	Uncharacterized small protein (DUF2292)
F5K02_04075	COG0196	riboflavin kinase activity
F5K02_04080	COG0670	Belongs to the BI1 family
F5K02_04085	COG1846	Transcriptional regulator
F5K02_04090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F5K02_04100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F5K02_04100	COG2124	cytochrome p450
F5K02_04115	COG1131	(ABC) transporter
F5K02_04130	COG1368	sulfuric ester hydrolase activity
F5K02_04135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F5K02_04140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_04145	COG1442	glycosyl transferase family 8
F5K02_04150	COG1216	Glycosyl transferase, family 2
F5K02_04155	COG1442	glycosyl transferase family 8
F5K02_04160	COG2223	nitrite transmembrane transporter activity
F5K02_04165	COG0531	amino acid
F5K02_04170	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_04175	COG0840	transmembrane signaling receptor activity
F5K02_04180	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_04185	COG0463	Glycosyl transferase, family 2
F5K02_04185	COG0457	Tetratricopeptide repeat
F5K02_04190	COG0488	(ABC) transporter
F5K02_04195	COG0789	Transcriptional regulator
F5K02_04200	COG2814	Major facilitator Superfamily
F5K02_04205	COG0488	(ABC) transporter
F5K02_04210	COG0513	Belongs to the DEAD box helicase family
F5K02_04215	COG0456	acetyltransferase
F5K02_04220	COG2130	NADP-dependent
F5K02_04235	COG3866	Pectate lyase
F5K02_04240	COG0471	metal ion transport
F5K02_04260	COG2972	Histidine kinase
F5K02_04260	COG0745	RESPONSE REGULATOR receiver
F5K02_04265	COG3279	Response regulator of the LytR AlgR family
F5K02_04275	COG3764	Sortase (surface protein transpeptidase)
F5K02_04285	COG3290	protein histidine kinase activity
F5K02_04290	COG4565	transcriptional regulatory protein
F5K02_04295	COG3181	Tripartite tricarboxylate transporter family receptor
F5K02_04300	COG2851	Citrate transporter
F5K02_04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_04310	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
F5K02_04320	COG2258	MOSC domain
F5K02_04340	COG0024	Methionine aminopeptidase
F5K02_04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_04345	COG1263	PTS System
F5K02_04355	COG1368	sulfuric ester hydrolase activity
F5K02_04365	COG0071	Belongs to the small heat shock protein (HSP20) family
F5K02_04380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_04380	COG1263	PTS System
F5K02_04385	COG0366	Alpha amylase catalytic
F5K02_04390	COG2188	Transcriptional regulator
F5K02_04395	COG0778	Nitroreductase
F5K02_04410	COG0737	Belongs to the 5'-nucleotidase family
F5K02_04415	COG0693	protein deglycase activity
F5K02_04420	COG1609	Transcriptional regulator
F5K02_04435	COG2814	Major facilitator Superfamily
F5K02_04445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F5K02_04450	COG4980	gas vesicle protein
F5K02_04455	COG1295	ribonuclease BN
F5K02_04460	COG0477	Major facilitator Superfamily
F5K02_04465	COG0387	Pfam Sodium calcium exchanger
F5K02_04475	COG0668	transmembrane transport
F5K02_04480	COG0535	radical SAM domain protein
F5K02_04490	COG0726	polysaccharide deacetylase
F5K02_04495	COG2084	Dehydrogenase
F5K02_04505	COG0598	Magnesium transport protein CorA
F5K02_04510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F5K02_04515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F5K02_04525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F5K02_04535	COG4637	Psort location Cytoplasmic, score
F5K02_04540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F5K02_04545	COG0022	dehydrogenase e1 component
F5K02_04550	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5K02_04555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F5K02_04560	COG3284	Transcriptional regulator
F5K02_04570	COG1486	melibiose metabolic process
F5K02_04575	COG1737	Transcriptional regulator
F5K02_04580	COG1263	PTS System
F5K02_04580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_04585	COG5434	Belongs to the glycosyl hydrolase 28 family
F5K02_04590	COG1132	(ABC) transporter
F5K02_04595	COG1132	(ABC) transporter
F5K02_04600	COG2259	Doxx family
F5K02_04605	COG2514	catechol 2,3-dioxygenase activity
F5K02_04610	COG1917	Cupin 2, conserved barrel domain protein
F5K02_04610	COG4977	sequence-specific DNA binding
F5K02_04615	COG2814	Major facilitator Superfamily
F5K02_04620	COG1082	Xylose isomerase domain protein TIM barrel
F5K02_04625	COG0673	inositol 2-dehydrogenase activity
F5K02_04635	COG1695	Transcriptional regulator
F5K02_04640	COG2249	NAD(P)H dehydrogenase (quinone) activity
F5K02_04645	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
F5K02_04650	COG0574	Belongs to the PEP-utilizing enzyme family
F5K02_04650	COG3848	Pyruvate phosphate dikinase
F5K02_04655	COG2732	(Barnase) inhibitor
F5K02_04660	COG2318	DinB family
F5K02_04665	COG2814	Major facilitator Superfamily
F5K02_04670	COG1846	Transcriptional regulator
F5K02_04675	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F5K02_04675	COG0392	lysyltransferase activity
F5K02_04680	COG0384	phenazine biosynthesis protein PhzF
F5K02_04685	COG0778	Nitroreductase
F5K02_04700	COG1090	epimerase
F5K02_04715	COG2814	Major facilitator Superfamily
F5K02_04725	COG3591	Belongs to the peptidase S1B family
F5K02_04740	COG3103	Sh3 type 3 domain protein
F5K02_04745	COG5658	integral membrane protein
F5K02_04750	COG0596	Alpha beta hydrolase
F5K02_04755	COG0463	Glycosyl transferase, family 2
F5K02_04760	COG4485	Bacterial membrane protein, YfhO
F5K02_04765	COG1988	membrane-bound metal-dependent
F5K02_04770	COG1194	a g-specific adenine glycosylase
F5K02_04780	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_04800	COG1132	(ABC) transporter
F5K02_04805	COG4129	membrane
F5K02_04815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F5K02_04820	COG0735	belongs to the Fur family
F5K02_04930	COG1757	Na H antiporter
F5K02_04935	COG3340	Belongs to the peptidase S51 family
F5K02_04945	COG0277	FAD linked oxidase domain protein
F5K02_04955	COG0747	negative chemotaxis
F5K02_04960	COG0601	transmembrane transport
F5K02_04965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F5K02_04970	COG0444	Belongs to the ABC transporter superfamily
F5K02_04975	COG4608	Belongs to the ABC transporter superfamily
F5K02_04980	COG0753	catalase activity
F5K02_04995	COG1116	anion transmembrane transporter activity
F5K02_05000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F5K02_05005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F5K02_05025	COG1476	TRANSCRIPTIONal
F5K02_05035	COG3382	B3 4 domain protein
F5K02_05040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F5K02_05050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F5K02_05055	COG0789	Transcriptional regulator
F5K02_05060	COG1664	Polymer-forming cytoskeletal
F5K02_05065	COG1664	Polymer-forming cytoskeletal
F5K02_05070	COG2766	serine protein kinase
F5K02_05085	COG1846	Transcriptional regulator
F5K02_05090	COG1566	PFAM secretion protein HlyD family protein
F5K02_05095	COG2814	Major facilitator Superfamily
F5K02_05100	COG0655	NAD(P)H dehydrogenase (quinone) activity
F5K02_05115	COG1725	Transcriptional regulator
F5K02_05120	COG1131	(ABC) transporter
F5K02_05125	COG1131	(ABC) transporter
F5K02_05130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F5K02_05135	COG1278	Cold shock
F5K02_05145	COG1464	Belongs to the NlpA lipoprotein family
F5K02_05150	COG3706	GGDEF domain
F5K02_05155	COG1823	symporter activity
F5K02_05175	COG5577	PFAM Coat F domain
F5K02_05180	COG0737	Belongs to the 5'-nucleotidase family
F5K02_05180	COG1525	nuclease
F5K02_05180	COG4085	toxin activity
F5K02_05185	COG3764	Sortase (surface protein transpeptidase)
F5K02_05190	COG0564	pseudouridine synthase activity
F5K02_05200	COG0517	IMP dehydrogenase activity
F5K02_05205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F5K02_05210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F5K02_05210	COG3153	acetyltransferase
F5K02_05215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F5K02_05220	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
F5K02_05225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F5K02_05235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F5K02_05240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F5K02_05245	COG2203	Gaf domain
F5K02_05245	COG4585	Histidine kinase
F5K02_05250	COG2197	response regulator
F5K02_05255	COG0431	NADPH-dependent FMN reductase
F5K02_05270	COG0791	NLP P60 protein
F5K02_05270	COG1388	LysM domain
F5K02_05275	COG1959	2 iron, 2 sulfur cluster binding
F5K02_05280	COG0668	transmembrane transport
F5K02_05285	COG2719	SpoVR family
F5K02_05290	COG1785	Belongs to the alkaline phosphatase family
F5K02_05295	COG0791	NLP P60 protein
F5K02_05295	COG1388	LysM domain
F5K02_05300	COG0583	DNA-binding transcription factor activity
F5K02_05305	COG0372	Belongs to the citrate synthase family
F5K02_05310	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_05315	COG0531	amino acid
F5K02_05320	COG0733	neurotransmitter:sodium symporter activity
F5K02_05335	COG1595	DNA-templated transcription, initiation
F5K02_05340	COG0204	Acyl-transferase
F5K02_05345	COG1253	flavin adenine dinucleotide binding
F5K02_05350	COG0789	Transcriptional regulator
F5K02_05355	COG0436	Aminotransferase
F5K02_05360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F5K02_05365	COG1253	flavin adenine dinucleotide binding
F5K02_05370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F5K02_05375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F5K02_05380	COG0584	glycerophosphoryl diester phosphodiesterase
F5K02_05390	COG0668	transmembrane transport
F5K02_05395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F5K02_05400	COG0726	polysaccharide deacetylase
F5K02_05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F5K02_05410	COG3226	Transcriptional regulator
F5K02_05420	COG0589	response to stress
F5K02_05425	COG1132	(ABC) transporter
F5K02_05430	COG1132	(ABC) transporter
F5K02_05435	COG0702	epimerase
F5K02_05455	COG0189	ligase activity
F5K02_05460	COG0189	ligase activity
F5K02_05475	COG4335	DNA alkylation repair
F5K02_05480	COG0561	phosphatase activity
F5K02_05485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F5K02_05495	COG0475	glutathione-regulated potassium exporter activity
F5K02_05500	COG0490	domain, Protein
F5K02_05510	COG1024	Enoyl-CoA hydratase
F5K02_05520	COG4152	abc transporter atp-binding protein
F5K02_05525	COG1668	transmembrane transport
F5K02_05530	COG0420	3'-5' exonuclease activity
F5K02_05535	COG4717	serine-type aminopeptidase activity
F5K02_05550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F5K02_05590	COG4980	gas vesicle protein
F5K02_05605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F5K02_05610	COG0537	adenosine 5'-monophosphoramidase activity
F5K02_05615	COG1131	(ABC) transporter
F5K02_05620	COG4473	ABC transporter
F5K02_05630	COG1473	amidohydrolase
F5K02_05635	COG3069	C4-dicarboxylate transmembrane transporter activity
F5K02_05640	COG2329	Antibiotic biosynthesis monooxygenase
F5K02_05645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5K02_05655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F5K02_05660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F5K02_05665	COG1309	transcriptional regulator
F5K02_05670	COG1511	domain protein
F5K02_05675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F5K02_05685	COG1363	Peptidase, m42
F5K02_05690	COG1301	dicarboxylic acid transport
F5K02_05700	COG1234	tRNA 3'-trailer cleavage
F5K02_05705	COG0095	Lipoate-protein ligase
F5K02_05710	COG0702	epimerase
F5K02_05715	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_05725	COG0501	Belongs to the peptidase M48B family
F5K02_05730	COG1404	Belongs to the peptidase S8 family
F5K02_05740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F5K02_05745	COG0406	alpha-ribazole phosphatase activity
F5K02_05750	COG0183	Belongs to the thiolase family
F5K02_05755	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_05760	COG1268	BioY protein
F5K02_05765	COG0840	transmembrane signaling receptor activity
F5K02_05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F5K02_05770	COG0723	plastoquinol--plastocyanin reductase activity
F5K02_05775	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_05785	COG4903	ComK protein
F5K02_05795	COG5646	InterPro IPR014922
F5K02_05820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F5K02_05835	COG0398	Pfam SNARE associated Golgi protein
F5K02_05840	COG0681	Belongs to the peptidase S26 family
F5K02_05845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F5K02_05850	COG1846	Transcriptional regulator
F5K02_05855	COG3180	Ammonia monooxygenase
F5K02_05860	COG2814	Major facilitator Superfamily
F5K02_05870	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
F5K02_05875	COG2323	membrane
F5K02_05890	COG0420	3'-5' exonuclease activity
F5K02_05895	COG0419	ATPase involved in DNA repair
F5K02_05900	COG1403	HNH endonuclease
F5K02_05940	COG0179	Fumarylacetoacetate (FAA) hydrolase
F5K02_05960	COG0367	asparagine synthase
F5K02_05965	COG1562	ergosterol biosynthetic process
F5K02_05970	COG0534	Mate efflux family protein
F5K02_05975	COG1917	Cupin 2, conserved barrel domain protein
F5K02_05975	COG2207	Transcriptional regulator
F5K02_05980	COG2318	DinB family
F5K02_05990	COG1357	PFAM Pentapeptide repeats (8 copies)
F5K02_05995	COG2153	protein acetylation
F5K02_06000	COG0646	methionine synthase
F5K02_06000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F5K02_06010	COG2996	Protein conserved in bacteria
F5K02_06015	COG1744	ABC transporter substrate-binding protein PnrA-like
F5K02_06020	COG0840	transmembrane signaling receptor activity
F5K02_06025	COG2124	cytochrome p450
F5K02_06035	COG1307	EDD domain protein, DegV family
F5K02_06040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_06055	COG0561	phosphatase activity
F5K02_06060	COG1073	alpha beta
F5K02_06065	COG2151	metal-sulfur cluster biosynthetic enzyme
F5K02_06075	COG0277	FAD linked oxidase domain protein
F5K02_06080	COG2271	Major facilitator Superfamily
F5K02_06090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F5K02_06100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F5K02_06105	COG0505	Belongs to the CarA family
F5K02_06110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F5K02_06115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F5K02_06135	COG2267	carboxylic ester hydrolase activity
F5K02_06145	COG1744	ABC transporter substrate-binding protein PnrA-like
F5K02_06160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F5K02_06165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F5K02_06170	COG5504	Zn-dependent protease
F5K02_06175	COG0444	Belongs to the ABC transporter superfamily
F5K02_06180	COG4608	Belongs to the ABC transporter superfamily
F5K02_06190	COG0601	transmembrane transport
F5K02_06195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F5K02_06205	COG0180	Tryptophanyl-tRNA synthetase
F5K02_06210	COG4166	transmembrane transport
F5K02_06215	COG0601	transmembrane transport
F5K02_06220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F5K02_06225	COG0444	Belongs to the ABC transporter superfamily
F5K02_06230	COG4608	Belongs to the ABC transporter superfamily
F5K02_06240	COG0456	acetyltransferase
F5K02_06245	COG1393	Belongs to the ArsC family
F5K02_06250	COG0861	Integral membrane protein TerC family
F5K02_06255	COG4862	establishment of competence for transformation
F5K02_06260	COG4469	Competence protein
F5K02_06265	COG1164	Oligoendopeptidase f
F5K02_06275	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F5K02_06280	COG2346	COG2346, Truncated hemoglobins
F5K02_06285	COG0741	lytic transglycosylase activity
F5K02_06290	COG4116	CYTH
F5K02_06300	COG2357	RelA SpoT domain protein
F5K02_06305	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F5K02_06310	COG0564	pseudouridine synthase activity
F5K02_06320	COG0475	glutathione-regulated potassium exporter activity
F5K02_06320	COG0569	domain protein
F5K02_06325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F5K02_06330	COG0352	thiamine-phosphate diphosphorylase activity
F5K02_06335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F5K02_06340	COG2104	thiamine diphosphate biosynthetic process
F5K02_06350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F5K02_06355	COG0351	phosphomethylpyrimidine kinase
F5K02_06360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F5K02_06415	COG0210	DNA helicase
F5K02_06435	COG1131	(ABC) transporter
F5K02_06445	COG2153	protein acetylation
F5K02_06455	COG2382	esterase
F5K02_06460	COG0626	cystathionine gamma-synthase activity
F5K02_06465	COG0626	cystathionine gamma-synthase activity
F5K02_06495	COG5444	nuclease activity
F5K02_06530	COG0135	phosphoribosylanthranilate isomerase activity
F5K02_06545	COG2367	Beta-lactamase
F5K02_06550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F5K02_06555	COG0477	Major facilitator Superfamily
F5K02_06560	COG1846	Transcriptional regulator
F5K02_06570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F5K02_06575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F5K02_06580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F5K02_06585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_06585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_06590	COG1447	Phosphotransferase system cellobiose-specific component IIA
F5K02_06600	COG1349	DNA-binding transcription factor activity
F5K02_06620	COG1285	pathogenesis
F5K02_06635	COG2205	protein histidine kinase activity
F5K02_06645	COG3383	formate dehydrogenase (NAD+) activity
F5K02_06650	COG2427	Protein of unknown function (DUF1641)
F5K02_06655	COG2124	cytochrome p450
F5K02_06660	COG1819	glycosyl
F5K02_06670	COG1587	Uroporphyrinogen-III synthase
F5K02_06675	COG0390	transport system, permease component
F5K02_06680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F5K02_06685	COG0697	spore germination
F5K02_06690	COG4297	protein containing double-stranded beta helix domain
F5K02_06700	COG1252	NADH dehydrogenase
F5K02_06710	COG2211	Major facilitator Superfamily
F5K02_06715	COG1609	Transcriptional regulator
F5K02_06720	COG0246	Mannitol dehydrogenase
F5K02_06725	COG2721	sulfolactate sulfo-lyase activity
F5K02_06730	COG0745	RESPONSE REGULATOR receiver
F5K02_06735	COG2770	Histidine kinase
F5K02_06735	COG2205	protein histidine kinase activity
F5K02_06750	COG0730	response to heat
F5K02_06755	COG2318	DinB family
F5K02_06760	COG0457	Tetratricopeptide repeat
F5K02_06770	COG1388	LysM domain
F5K02_06770	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_06770	COG5632	N-Acetylmuramoyl-L-alanine amidase
F5K02_06780	COG4195	phage-related replication protein
F5K02_06790	COG2856	Zn peptidase
F5K02_06795	COG1396	sequence-specific DNA binding
F5K02_06805	COG1522	sequence-specific DNA binding
F5K02_06810	COG1484	DNA-dependent DNA replication
F5K02_06825	COG1595	DNA-templated transcription, initiation
F5K02_06830	COG5484	DNA packaging
F5K02_06830	COG3728	DNA packaging
F5K02_06835	COG1783	phage Terminase large subunit
F5K02_06840	COG5518	Phage portal protein
F5K02_06845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F5K02_06850	COG4653	Phage capsid family
F5K02_06900	COG3953	SLT domain
F5K02_06900	COG5412	phage tail tape measure protein
F5K02_06900	COG3953	SLT domain
F5K02_06900	COG5412	phage tail tape measure protein
F5K02_06900	COG3953	SLT domain
F5K02_06900	COG5412	phage tail tape measure protein
F5K02_06905	COG1652	LysM domain
F5K02_06910	COG4193	domain, Protein
F5K02_06920	COG3628	GPW Gp25 family protein
F5K02_06925	COG3299	homolog of phage Mu protein gp47
F5K02_06930	COG3778	Protein conserved in bacteria
F5K02_06970	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_06970	COG5632	N-Acetylmuramoyl-L-alanine amidase
F5K02_06985	COG0306	phosphate transporter
F5K02_06990	COG1392	Phosphate transport regulator
F5K02_06995	COG0531	amino acid
F5K02_07000	COG0346	lactoylglutathione lyase activity
F5K02_07005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F5K02_07010	COG0463	Glycosyl transferase, family 2
F5K02_07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F5K02_07020	COG0477	Major facilitator Superfamily
F5K02_07025	COG2362	D-Aminopeptidase
F5K02_07030	COG0601	transmembrane transport
F5K02_07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F5K02_07040	COG0444	Belongs to the ABC transporter superfamily
F5K02_07045	COG4166	transmembrane transport
F5K02_07050	COG1619	proteins homologs of microcin C7 resistance protein MccF
F5K02_07055	COG4948	Mandelate Racemase Muconate Lactonizing
F5K02_07060	COG0791	NLP P60 protein
F5K02_07065	COG4608	Belongs to the ABC transporter superfamily
F5K02_07070	COG2706	6-phosphogluconolactonase activity
F5K02_07075	COG1834	amidinotransferase
F5K02_07080	COG1607	acyl-coa hydrolase
F5K02_07085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F5K02_07090	COG2076	Multidrug Resistance protein
F5K02_07095	COG2076	Multidrug Resistance protein
F5K02_07100	COG0788	formyltetrahydrofolate deformylase activity
F5K02_07105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F5K02_07115	COG1764	response to oxidative stress
F5K02_07120	COG1846	Transcriptional regulator
F5K02_07125	COG1764	response to oxidative stress
F5K02_07140	COG0463	Glycosyl transferase, family 2
F5K02_07140	COG0457	Tetratricopeptide repeat
F5K02_07150	COG2814	Major facilitator Superfamily
F5K02_07155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F5K02_07165	COG1404	Belongs to the peptidase S8 family
F5K02_07170	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_07175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F5K02_07180	COG1122	ATPase activity
F5K02_07185	COG4721	ABC-type cobalt transport system, permease component
F5K02_07190	COG1388	LysM domain
F5K02_07190	COG3858	chitin binding
F5K02_07210	COG2239	Acts as a magnesium transporter
F5K02_07215	COG0789	Transcriptional regulator
F5K02_07230	COG1846	Transcriptional regulator
F5K02_07235	COG0726	polysaccharide deacetylase
F5K02_07240	COG3285	dna ligase
F5K02_07240	COG1793	dna ligase
F5K02_07245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F5K02_07250	COG0586	Pfam SNARE associated Golgi protein
F5K02_07255	COG0861	Integral membrane protein TerC family
F5K02_07260	COG1191	sigma factor activity
F5K02_07285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F5K02_07290	COG2323	membrane
F5K02_07300	COG3594	Acyltransferase
F5K02_07305	COG5002	protein histidine kinase activity
F5K02_07310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F5K02_07325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F5K02_07330	COG0436	Aminotransferase
F5K02_07360	COG3852	Histidine kinase
F5K02_07365	COG1846	Transcriptional regulator
F5K02_07370	COG1360	Flagellar Motor Protein
F5K02_07375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F5K02_07385	COG0542	response to heat
F5K02_07395	COG3949	Membrane
F5K02_07410	COG0720	synthase
F5K02_07415	COG0602	queuosine metabolic process
F5K02_07430	COG1733	regulation of RNA biosynthetic process
F5K02_07435	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_07445	COG1388	LysM domain
F5K02_07445	COG4641	Protein conserved in bacteria
F5K02_07450	COG1388	LysM domain
F5K02_07455	COG3858	chitin binding
F5K02_07470	COG4873	Protein conserved in bacteria
F5K02_07480	COG3773	Cell wall hydrolase
F5K02_07485	COG2244	polysaccharide biosynthetic process
F5K02_07490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_07495	COG2217	Heavy metal translocating P-type atpase
F5K02_07500	COG0006	proline dipeptidase activity
F5K02_07505	COG1609	Transcriptional regulator
F5K02_07510	COG3711	transcriptional antiterminator
F5K02_07515	COG1263	PTS System
F5K02_07515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_07515	COG2190	(PTS) system
F5K02_07520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_07525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F5K02_07535	COG1533	DNA photolyase activity
F5K02_07540	COG0840	transmembrane signaling receptor activity
F5K02_07545	COG2084	Dehydrogenase
F5K02_07550	COG2340	Cysteine-rich secretory protein family
F5K02_07555	COG0768	penicillin binding
F5K02_07560	COG4191	Histidine kinase
F5K02_07565	COG0436	Aminotransferase
F5K02_07575	COG0835	chemotaxis
F5K02_07575	COG0784	Response regulator, receiver
F5K02_07585	COG2814	Major facilitator Superfamily
F5K02_07590	COG1376	ErfK ybiS ycfS ynhG family protein
F5K02_07595	COG1408	metallophosphoesterase
F5K02_07600	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_07610	COG2200	EAL domain
F5K02_07615	COG4703	Protein of unknown function (DUF1797)
F5K02_07620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
F5K02_07630	COG0517	IMP dehydrogenase activity
F5K02_07635	COG0583	DNA-binding transcription factor activity
F5K02_07640	COG0716	FMN binding
F5K02_07650	COG0716	FMN binding
F5K02_07670	COG0668	transmembrane transport
F5K02_07675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_07695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F5K02_07700	COG0303	'Molybdopterin
F5K02_07705	COG1763	Mo-molybdopterin cofactor biosynthetic process
F5K02_07710	COG0314	molybdopterin synthase activity
F5K02_07715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F5K02_07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F5K02_07730	COG1136	(ABC) transporter
F5K02_07735	COG0577	efflux transmembrane transporter activity
F5K02_07740	COG1349	DNA-binding transcription factor activity
F5K02_07745	COG1105	Belongs to the carbohydrate kinase PfkB family
F5K02_07750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5K02_07750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5K02_07750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_07755	COG0681	Belongs to the peptidase S26 family
F5K02_07765	COG0488	(ABC) transporter
F5K02_07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F5K02_07775	COG2309	aminopeptidase activity
F5K02_07785	COG1077	Cell shape determining protein MreB Mrl
F5K02_07795	COG2002	toxin-antitoxin pair type II binding
F5K02_07800	COG3852	Histidine kinase
F5K02_07805	COG2105	PFAM AIG2 family protein
F5K02_07805	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F5K02_07810	COG0569	domain protein
F5K02_07820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F5K02_07830	COG0561	phosphatase activity
F5K02_07835	COG0242	peptide deformylase activity
F5K02_07845	COG0497	DNA recombination
F5K02_07860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_07860	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_07860	COG3321	synthase
F5K02_07860	COG4221	oxidoreductase activity
F5K02_07865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_07865	COG0300	oxidoreductase activity
F5K02_07865	COG3321	synthase
F5K02_07865	COG4221	oxidoreductase activity
F5K02_07870	COG4221	oxidoreductase activity
F5K02_07870	COG3321	synthase
F5K02_07870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_07870	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_07875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_07875	COG3321	synthase
F5K02_07875	COG4221	oxidoreductase activity
F5K02_07875	COG0300	oxidoreductase activity
F5K02_07880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_07880	COG0300	oxidoreductase activity
F5K02_07880	COG3321	synthase
F5K02_07880	COG4221	oxidoreductase activity
F5K02_07885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_07885	COG0300	oxidoreductase activity
F5K02_07885	COG4221	oxidoreductase activity
F5K02_07885	COG3321	synthase
F5K02_07890	COG4221	oxidoreductase activity
F5K02_07890	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_07890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_07890	COG3321	synthase
F5K02_07895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F5K02_07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F5K02_07905	COG0022	dehydrogenase e1 component
F5K02_07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5K02_07915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F5K02_07920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_07935	COG1982	Orn Lys Arg decarboxylase major
F5K02_07960	COG0483	inositol monophosphate 1-phosphatase activity
F5K02_07970	COG3227	Zinc metalloprotease (Elastase)
F5K02_07975	COG1595	DNA-templated transcription, initiation
F5K02_07995	COG1217	gtp-binding protein TYPA
F5K02_08005	COG4896	Protein conserved in bacteria
F5K02_08015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F5K02_08020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F5K02_08025	COG2066	Belongs to the glutaminase family
F5K02_08035	COG0772	Belongs to the SEDS family
F5K02_08040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F5K02_08055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F5K02_08055	COG2010	Cytochrome c
F5K02_08060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F5K02_08065	COG1845	cytochrome c oxidase, subunit III
F5K02_08070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F5K02_08075	COG3336	cytochrome c oxidase
F5K02_08085	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F5K02_08090	COG2340	Cysteine-rich secretory protein family
F5K02_08105	COG3679	Belongs to the UPF0342 family
F5K02_08120	COG0742	ribosomal rna small subunit methyltransferase
F5K02_08130	COG3314	Sporulation integral membrane protein YlbJ
F5K02_08135	COG1752	Esterase of the alpha-beta hydrolase superfamily
F5K02_08140	COG3480	Lon protease (S16) C-terminal proteolytic domain
F5K02_08155	COG1399	metal-binding, possibly nucleic acid-binding protein
F5K02_08175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F5K02_08195	COG4839	cell division protein FtsL
F5K02_08200	COG0768	penicillin binding
F5K02_08205	COG0768	penicillin binding
F5K02_08225	COG0772	Belongs to the SEDS family
F5K02_08240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F5K02_08245	COG0849	cell division
F5K02_08250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F5K02_08255	COG4412	M6 family metalloprotease domain protein
F5K02_08255	COG1404	Belongs to the peptidase S8 family
F5K02_08265	COG1191	sigma factor activity
F5K02_08270	COG1191	sigma factor activity
F5K02_08275	COG1119	ATPase activity
F5K02_08280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5K02_08285	COG1873	PFAM PRC-barrel domain
F5K02_08290	COG1496	oxidoreductase activity
F5K02_08295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F5K02_08305	COG0762	integral membrane protein
F5K02_08310	COG2302	S4 RNA-binding domain
F5K02_08315	COG3599	regulation of cell shape
F5K02_08320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F5K02_08325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F5K02_08335	COG0564	pseudouridine synthase activity
F5K02_08345	COG2233	PERMEase
F5K02_08355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F5K02_08360	COG0505	Belongs to the CarA family
F5K02_08365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F5K02_08380	COG0284	orotidine-5'-phosphate decarboxylase activity
F5K02_08385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F5K02_08395	COG0306	phosphate transporter
F5K02_08410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F5K02_08415	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
F5K02_08420	COG1648	precorrin-2 dehydrogenase activity
F5K02_08435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F5K02_08440	COG1561	YicC-like family, N-terminal region
F5K02_08450	COG0194	GDP metabolic process
F5K02_08460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F5K02_08465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F5K02_08470	COG0242	peptide deformylase activity
F5K02_08480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F5K02_08480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F5K02_08490	COG0631	protein serine/threonine phosphatase activity
F5K02_08495	COG2815	serine threonine protein kinase
F5K02_08495	COG0515	serine threonine protein kinase
F5K02_08505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F5K02_08510	COG1564	THIamine pyrophosphokinase
F5K02_08525	COG1302	Protein conserved in bacteria
F5K02_08530	COG1461	Dihydroxyacetone kinase
F5K02_08535	COG1760	l-serine dehydratase
F5K02_08540	COG1760	l-serine dehydratase
F5K02_08545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F5K02_08560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F5K02_08565	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_08580	COG1196	nuclear chromosome segregation
F5K02_08585	COG0552	protein localization to endoplasmic reticulum
F5K02_08600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F5K02_08610	COG1837	Belongs to the UPF0109 family
F5K02_08635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F5K02_08650	COG2257	FlhB HrpN YscU SpaS Family
F5K02_08660	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F5K02_08665	COG0758	DNA mediated transformation
F5K02_08670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F5K02_08680	COG4974	Belongs to the 'phage' integrase family
F5K02_08700	COG1815	bacterial-type flagellum-dependent cell motility
F5K02_08705	COG1558	bacterial-type flagellum-dependent cell motility
F5K02_08710	COG1677	Flagellar hook-basal body complex protein FliE
F5K02_08715	COG1766	The M ring may be actively involved in energy transduction
F5K02_08720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F5K02_08725	COG1317	bacterial-type flagellum organization
F5K02_08730	COG1157	protein secretion by the type III secretion system
F5K02_08735	COG2882	bacterial-type flagellum organization
F5K02_08740	COG3334	PFAM MgtE intracellular
F5K02_08745	COG3144	bacterial-type flagellum assembly
F5K02_08750	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F5K02_08755	COG4786	Flagellar basal body rod
F5K02_08760	COG1582	Flagellar protein (FlbD)
F5K02_08765	COG1580	Controls the rotational direction of flagella during chemotaxis
F5K02_08770	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F5K02_08775	COG1776	CheC inhibitor of MCP methylation
F5K02_08775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F5K02_08780	COG2201	protein-glutamate methylesterase activity
F5K02_08785	COG3190	flagellar
F5K02_08790	COG1338	Plays a role in the flagellum-specific transport system
F5K02_08795	COG1987	bacterial-type flagellum assembly
F5K02_08800	COG1684	flagellar biosynthetic protein fliR
F5K02_08805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F5K02_08810	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F5K02_08815	COG1419	protein localization to endoplasmic reticulum
F5K02_08820	COG0455	bacterial-type flagellum organization
F5K02_08825	COG2201	protein-glutamate methylesterase activity
F5K02_08830	COG0643	Histidine kinase
F5K02_08830	COG2198	Histidine kinase
F5K02_08835	COG0835	chemotaxis
F5K02_08840	COG1776	CheC inhibitor of MCP methylation
F5K02_08850	COG1191	sigma factor activity
F5K02_08880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F5K02_08885	COG4589	Belongs to the CDS family
F5K02_08895	COG0750	zinc metalloprotease
F5K02_08905	COG2176	DNA-directed DNA polymerase activity
F5K02_08915	COG0195	Participates in both transcription termination and antitermination
F5K02_08920	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F5K02_08925	COG1358	cellular component organization or biogenesis
F5K02_08935	COG1550	Protein conserved in bacteria
F5K02_08950	COG0196	riboflavin kinase activity
F5K02_08965	COG0726	polysaccharide deacetylase
F5K02_08970	COG0612	Peptidase, M16
F5K02_08975	COG1873	PFAM PRC-barrel domain
F5K02_08980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F5K02_08985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F5K02_08990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F5K02_08995	COG0527	aspartate kinase activity
F5K02_09005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F5K02_09010	COG0740	serine-type endopeptidase activity
F5K02_09020	COG4980	gas vesicle protein
F5K02_09020	COG1674	ftsk spoiiie
F5K02_09025	COG2188	Transcriptional regulator
F5K02_09030	COG2814	Major facilitator Superfamily
F5K02_09035	COG1846	Transcriptional regulator
F5K02_09040	COG1033	growth of symbiont in host cell
F5K02_09040	COG2409	Drug exporters of the RND superfamily
F5K02_09045	COG0612	Peptidase, M16
F5K02_09050	COG0612	Peptidase, M16
F5K02_09055	COG0300	oxidoreductase activity
F5K02_09070	COG1426	Protein conserved in bacteria
F5K02_09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F5K02_09090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F5K02_09100	COG1692	metallophosphoesterase
F5K02_09105	COG2359	stage V sporulation protein S
F5K02_09125	COG4550	Control of competence regulator ComK, YlbF/YmcA
F5K02_09185	COG5444	nuclease activity
F5K02_09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_09220	COG3425	synthase
F5K02_09225	COG1024	Enoyl-CoA hydratase
F5K02_09230	COG1024	Enoyl-CoA hydratase
F5K02_09235	COG3321	synthase
F5K02_09235	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_09235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_09235	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_09235	COG0300	oxidoreductase activity
F5K02_09240	COG4221	oxidoreductase activity
F5K02_09240	COG3321	synthase
F5K02_09240	COG0300	oxidoreductase activity
F5K02_09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_09245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_09245	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_09245	COG3321	synthase
F5K02_09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_09245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_09245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_09245	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_09245	COG3321	synthase
F5K02_09245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_09250	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_09250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_09250	COG4221	oxidoreductase activity
F5K02_09250	COG3321	synthase
F5K02_09255	COG3321	synthase
F5K02_09255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F5K02_09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_09255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F5K02_09260	COG2124	cytochrome p450
F5K02_09265	COG3209	COG3209 Rhs family protein
F5K02_09270	COG3619	membrane
F5K02_09280	COG1404	Belongs to the peptidase S8 family
F5K02_09290	COG4195	phage-related replication protein
F5K02_09295	COG1764	response to oxidative stress
F5K02_09305	COG2076	Multidrug Resistance protein
F5K02_09345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F5K02_09350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F5K02_09355	COG4112	unkown
F5K02_09360	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_09380	COG1525	nuclease
F5K02_09385	COG4282	regulation of fungal-type cell wall biogenesis
F5K02_09395	COG5444	nuclease activity
F5K02_09440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F5K02_09445	COG0457	Tetratricopeptide repeat
F5K02_09465	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_09465	COG5632	N-Acetylmuramoyl-L-alanine amidase
F5K02_09470	COG5434	Belongs to the glycosyl hydrolase 28 family
F5K02_09490	COG2433	Pfam Transposase IS66
F5K02_09500	COG1196	nuclear chromosome segregation
F5K02_09500	COG0741	lytic transglycosylase activity
F5K02_09500	COG0739	heme binding
F5K02_09515	COG0582	viral genome integration into host DNA
F5K02_09615	COG4373	Mu-like prophage FluMu protein gp28
F5K02_09655	COG0776	regulation of translation
F5K02_09745	COG3655	Transcriptional regulator
F5K02_09850	COG3655	Transcriptional regulator
F5K02_09965	COG1793	dna ligase
F5K02_09970	COG2135	peptidase activity
F5K02_09985	COG4195	phage-related replication protein
F5K02_10005	COG2404	hydrolase activity, acting on ester bonds
F5K02_10045	COG3584	3D domain protein
F5K02_10055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F5K02_10060	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
F5K02_10135	COG1780	Probably involved in ribonucleotide reductase function
F5K02_10140	COG1372	Participates in initiation and elongation during chromosome replication
F5K02_10140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F5K02_10150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F5K02_10155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_10165	COG0756	dUTP diphosphatase activity
F5K02_10185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F5K02_10190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F5K02_10225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F5K02_10255	COG3331	DNA recombination
F5K02_10265	COG0464	growth
F5K02_10270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F5K02_10275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F5K02_10280	COG0789	Transcriptional regulator
F5K02_10285	COG0174	glutamine synthetase
F5K02_10295	COG4282	regulation of fungal-type cell wall biogenesis
F5K02_10320	COG2211	Major facilitator Superfamily
F5K02_10325	COG3507	Belongs to the glycosyl hydrolase 43 family
F5K02_10340	COG1070	Carbohydrate kinase
F5K02_10345	COG0574	Belongs to the PEP-utilizing enzyme family
F5K02_10345	COG3848	Pyruvate phosphate dikinase
F5K02_10370	COG1064	alcohol dehydrogenase
F5K02_10395	COG0456	acetyltransferase
F5K02_10420	COG3397	chitin binding
F5K02_10430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F5K02_10440	COG5434	Belongs to the glycosyl hydrolase 28 family
F5K02_10445	COG0756	dUTP diphosphatase activity
F5K02_10455	COG4195	phage-related replication protein
F5K02_10485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F5K02_10495	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F5K02_10515	COG0785	Cytochrome C biogenesis protein
F5K02_10520	COG2201	protein-glutamate methylesterase activity
F5K02_10525	COG4846	Membrane protein involved in cytochrome C biogenesis
F5K02_10535	COG0071	Belongs to the small heat shock protein (HSP20) family
F5K02_10550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F5K02_10555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_10575	COG0824	Thioesterase
F5K02_10585	COG4841	protein insertion into membrane
F5K02_10595	COG1832	CoA-binding protein
F5K02_10600	COG0187	DNA topoisomerase II activity
F5K02_10605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F5K02_10615	COG1115	amino acid carrier protein
F5K02_10625	COG1063	alcohol dehydrogenase
F5K02_10630	COG0800	Aldolase
F5K02_10635	COG1312	Catalyzes the dehydration of D-mannonate
F5K02_10640	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_10645	COG1609	Transcriptional regulator
F5K02_10650	COG2271	Major facilitator Superfamily
F5K02_10690	COG2205	protein histidine kinase activity
F5K02_10695	COG0745	RESPONSE REGULATOR receiver
F5K02_10705	COG3507	Belongs to the glycosyl hydrolase 43 family
F5K02_10730	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_10735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F5K02_10740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F5K02_10745	COG2610	gluconate transmembrane transporter activity
F5K02_10750	COG2124	cytochrome p450
F5K02_10770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F5K02_10780	COG2246	polysaccharide biosynthetic process
F5K02_10785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F5K02_10790	COG0586	Pfam SNARE associated Golgi protein
F5K02_10795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F5K02_10800	COG1024	Enoyl-CoA hydratase
F5K02_10805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F5K02_10810	COG0511	ligase activity, forming carbon-carbon bonds
F5K02_10815	COG0439	Biotin carboxylase
F5K02_10820	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_10825	COG1960	acyl-CoA dehydrogenase activity
F5K02_10830	COG1649	PFAM Uncharacterised BCR, COG1649
F5K02_10840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_10840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F5K02_10845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_10850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_10855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_10860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_10870	COG2027	D-alanyl-D-alanine carboxypeptidase
F5K02_10875	COG2017	converts alpha-aldose to the beta-anomer
F5K02_10880	COG0534	Mate efflux family protein
F5K02_10895	COG0582	viral genome integration into host DNA
F5K02_10900	COG0166	Belongs to the GPI family
F5K02_10905	COG0405	Gamma-glutamyltransferase
F5K02_10910	COG2814	Major facilitator Superfamily
F5K02_10915	COG0640	Transcriptional regulator
F5K02_10920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F5K02_10930	COG0604	alcohol dehydrogenase
F5K02_10940	COG0493	'glutamate synthase
F5K02_10945	COG0067	glutamate synthase
F5K02_10945	COG0069	glutamate synthase activity
F5K02_10945	COG0070	glutamate synthase
F5K02_10950	COG0583	DNA-binding transcription factor activity
F5K02_10955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F5K02_10970	COG0300	oxidoreductase activity
F5K02_10975	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F5K02_10985	COG2814	Major facilitator Superfamily
F5K02_10990	COG1070	Carbohydrate kinase
F5K02_10995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F5K02_11000	COG0243	molybdopterin cofactor binding
F5K02_11030	COG5444	nuclease activity
F5K02_11035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5K02_11045	COG1309	transcriptional regulator
F5K02_11050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_11060	COG0640	Transcriptional regulator
F5K02_11065	COG0741	lytic transglycosylase activity
F5K02_11070	COG2322	membrane
F5K02_11085	COG1619	proteins homologs of microcin C7 resistance protein MccF
F5K02_11095	COG1388	LysM domain
F5K02_11095	COG3584	3D domain protein
F5K02_11100	COG0514	ATP-dependent DNA helicase (RecQ)
F5K02_11110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F5K02_11115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F5K02_11130	COG0071	Belongs to the small heat shock protein (HSP20) family
F5K02_11160	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_11165	COG1657	PFAM Prenyltransferase squalene oxidase
F5K02_11170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F5K02_11175	COG0733	neurotransmitter:sodium symporter activity
F5K02_11180	COG0385	Bile acid
F5K02_11185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_11195	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5K02_11205	COG4548	von Willebrand factor, type A
F5K02_11210	COG0714	Associated with various cellular activities
F5K02_11215	COG2032	superoxide dismutase activity
F5K02_11220	COG0791	NLP P60 protein
F5K02_11220	COG1388	LysM domain
F5K02_11225	COG1819	glycosyl
F5K02_11230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F5K02_11235	COG0534	Mate efflux family protein
F5K02_11240	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_11245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F5K02_11250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F5K02_11260	COG2962	Rard protein
F5K02_11275	COG1942	4-Oxalocrotonate Tautomerase
F5K02_11285	COG1733	regulation of RNA biosynthetic process
F5K02_11290	COG0778	Nitroreductase
F5K02_11295	COG0400	carboxylic ester hydrolase activity
F5K02_11300	COG0346	lactoylglutathione lyase activity
F5K02_11310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F5K02_11320	COG2723	6-phospho-beta-galactosidase activity
F5K02_11325	COG2188	Transcriptional regulator
F5K02_11330	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_11330	COG0793	Belongs to the peptidase S41A family
F5K02_11335	COG2226	methyltransferase
F5K02_11345	COG1876	peptidase activity
F5K02_11365	COG0671	phosphoesterase, PA-phosphatase related
F5K02_11395	COG1509	lysine 2,3-aminomutase activity
F5K02_11400	COG0456	acetyltransferase
F5K02_11405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5K02_11410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F5K02_11415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F5K02_11420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F5K02_11425	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F5K02_11435	COG0456	acetyltransferase
F5K02_11440	COG0463	Glycosyl transferase, family 2
F5K02_11455	COG4641	Protein conserved in bacteria
F5K02_11465	COG1086	Polysaccharide biosynthesis protein
F5K02_11525	COG1388	LysM domain
F5K02_11530	COG0457	Tetratricopeptide repeat
F5K02_11540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F5K02_11545	COG3391	amine dehydrogenase activity
F5K02_11565	COG5444	nuclease activity
F5K02_11570	COG4282	regulation of fungal-type cell wall biogenesis
F5K02_11575	COG1525	nuclease
F5K02_11580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F5K02_11600	COG1846	Transcriptional regulator
F5K02_11605	COG4698	Protein conserved in bacteria
F5K02_11610	COG2755	lipolytic protein G-D-S-L family
F5K02_11615	COG1999	signal sequence binding
F5K02_11625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F5K02_11630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F5K02_11635	COG1272	protein, Hemolysin III
F5K02_11640	COG0204	Acyl-transferase
F5K02_11645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F5K02_11660	COG2521	methyltransferase
F5K02_11660	COG2136	Putative SAM-dependent methyltransferase
F5K02_11675	COG1413	lyase activity
F5K02_11685	COG0386	Belongs to the glutathione peroxidase family
F5K02_11695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F5K02_11705	COG1278	Cold shock
F5K02_11725	COG0328	RNA-DNA hybrid ribonuclease activity
F5K02_11730	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F5K02_11735	COG0328	RNA-DNA hybrid ribonuclease activity
F5K02_11745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F5K02_11760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F5K02_11770	COG1755	Isoprenylcysteine carboxyl methyltransferase
F5K02_11775	COG3424	synthase
F5K02_11795	COG2323	membrane
F5K02_11800	COG1335	isochorismatase
F5K02_11810	COG2233	PERMEase
F5K02_11820	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F5K02_11825	COG1199	ATP-dependent helicase activity
F5K02_11840	COG0116	Belongs to the methyltransferase superfamily
F5K02_11870	COG3359	exonuclease
F5K02_11875	COG1111	helicase
F5K02_11875	COG1205	dead DEAH box helicase
F5K02_11880	COG2190	(PTS) system
F5K02_11885	COG0071	Belongs to the small heat shock protein (HSP20) family
F5K02_11925	COG4499	WXG100 protein secretion system (Wss), protein YukC
F5K02_11925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5K02_11935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F5K02_11940	COG3935	DnaD domain protein
F5K02_11950	COG0436	Aminotransferase
F5K02_11955	COG5353	protein conserved in bacteria
F5K02_11965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F5K02_11965	COG1199	ATP-dependent helicase activity
F5K02_11995	COG0438	transferase activity, transferring glycosyl groups
F5K02_12000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F5K02_12015	COG1694	Mazg nucleotide pyrophosphohydrolase
F5K02_12020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_12025	COG2140	Oxalate decarboxylase
F5K02_12035	COG4347	Protein of unknown function (DUF1405)
F5K02_12040	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F5K02_12040	COG2010	Cytochrome c
F5K02_12045	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F5K02_12050	COG0723	plastoquinol--plastocyanin reductase activity
F5K02_12065	COG0457	Tetratricopeptide repeat
F5K02_12075	COG0287	Prephenate dehydrogenase
F5K02_12110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F5K02_12115	COG4401	Chorismate mutase type I
F5K02_12130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F5K02_12135	COG0105	UTP biosynthetic process
F5K02_12140	COG0142	geranyltranstransferase activity
F5K02_12150	COG0142	geranyltranstransferase activity
F5K02_12165	COG0776	regulation of translation
F5K02_12170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F5K02_12210	COG0539	negative regulation of cytoplasmic translation
F5K02_12220	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F5K02_12225	COG2959	enzyme of heme biosynthesis
F5K02_12230	COG3773	Cell wall hydrolase
F5K02_12230	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_12235	COG2339	peptidase activity
F5K02_12240	COG0492	ferredoxin-NADP+ reductase activity
F5K02_12245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F5K02_12250	COG4862	establishment of competence for transformation
F5K02_12255	COG1408	metallophosphoesterase
F5K02_12265	COG1388	LysM domain
F5K02_12270	COG1266	CAAX protease self-immunity
F5K02_12275	COG0514	ATP-dependent DNA helicase (RecQ)
F5K02_12280	COG4955	Helix-turn-helix domain
F5K02_12285	COG1141	Ferredoxin
F5K02_12290	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F5K02_12295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F5K02_12305	COG1595	DNA-templated transcription, initiation
F5K02_12310	COG5002	protein histidine kinase activity
F5K02_12315	COG0745	RESPONSE REGULATOR receiver
F5K02_12320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F5K02_12325	COG1333	cytochrome c biogenesis protein
F5K02_12330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_12335	COG1187	pseudouridine synthase activity
F5K02_12340	COG0700	Nucleoside recognition
F5K02_12345	COG2715	membrane protein required for spore maturation
F5K02_12350	COG1686	Belongs to the peptidase S11 family
F5K02_12375	COG1547	Domain of unknown function (DUF309)
F5K02_12385	COG0456	acetyltransferase
F5K02_12400	COG0307	riboflavin synthase, alpha
F5K02_12405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F5K02_12405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F5K02_12415	COG0681	Belongs to the peptidase S26 family
F5K02_12425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F5K02_12430	COG4086	secreted protein
F5K02_12435	COG0019	diaminopimelate decarboxylase activity
F5K02_12440	COG0697	spore germination
F5K02_12455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F5K02_12475	COG1191	sigma factor activity
F5K02_12485	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_12490	COG1686	Belongs to the peptidase S11 family
F5K02_12495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F5K02_12500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F5K02_12505	COG4974	Belongs to the 'phage' integrase family
F5K02_12515	COG0735	belongs to the Fur family
F5K02_12520	COG1300	Membrane
F5K02_12535	COG0281	malic enzyme
F5K02_12540	COG1757	Na H antiporter
F5K02_12545	COG1027	Aspartate ammonia-lyase
F5K02_12550	COG0252	asparaginase activity
F5K02_12555	COG1396	sequence-specific DNA binding
F5K02_12560	COG1379	DNA repair
F5K02_12565	COG0494	nUDIX hydrolase
F5K02_12575	COG0667	Aldo Keto reductase
F5K02_12585	COG1073	alpha beta
F5K02_12595	COG4918	Iron-sulphur cluster biosynthesis
F5K02_12600	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F5K02_12600	COG0456	acetyltransferase
F5K02_12605	COG2329	Antibiotic biosynthesis monooxygenase
F5K02_12610	COG0456	acetyltransferase
F5K02_12615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F5K02_12630	COG0628	permease
F5K02_12640	COG0346	lactoylglutathione lyase activity
F5K02_12650	COG3048	D-serine ammonia-lyase activity
F5K02_12655	COG0300	oxidoreductase activity
F5K02_12660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_12665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F5K02_12670	COG1024	Enoyl-CoA hydratase
F5K02_12675	COG3425	synthase
F5K02_12680	COG2124	cytochrome p450
F5K02_12685	COG3321	synthase
F5K02_12685	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_12685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_12690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12690	COG3321	synthase
F5K02_12690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_12690	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_12695	COG0300	oxidoreductase activity
F5K02_12695	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_12695	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12695	COG3321	synthase
F5K02_12695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12700	COG0300	oxidoreductase activity
F5K02_12700	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_12700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12700	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12700	COG3321	synthase
F5K02_12705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_12705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12705	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_12705	COG3321	synthase
F5K02_12710	COG0300	oxidoreductase activity
F5K02_12710	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12710	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_12710	COG3321	synthase
F5K02_12715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_12715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_12715	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12715	COG3321	synthase
F5K02_12715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F5K02_12720	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_12725	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_12740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F5K02_12740	COG2070	2-Nitropropane dioxygenase
F5K02_12750	COG0250	Participates in transcription elongation, termination and antitermination
F5K02_12770	COG0596	Alpha beta hydrolase
F5K02_12785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F5K02_12790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F5K02_12805	COG0706	membrane insertase activity
F5K02_12810	COG2195	Cleaves the N-terminal amino acid of tripeptides
F5K02_12815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F5K02_12820	COG0346	lactoylglutathione lyase activity
F5K02_12830	COG1376	ErfK ybiS ycfS ynhG family protein
F5K02_12835	COG4129	membrane
F5K02_12840	COG1126	abc transporter atp-binding protein
F5K02_12845	COG0765	amino acid transport
F5K02_12850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_12860	COG1597	lipid kinase activity
F5K02_12865	COG0508	dehydrogenase complex catalyzes the overall conversion of
F5K02_12870	COG0022	dehydrogenase e1 component
F5K02_12875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F5K02_12880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F5K02_12885	COG3426	butyrate kinase activity
F5K02_12890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F5K02_12895	COG0280	phosphate acetyltransferase
F5K02_12900	COG3290	protein histidine kinase activity
F5K02_12900	COG3829	transcription factor binding
F5K02_12910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F5K02_12915	COG2079	MmgE PrpD family protein
F5K02_12920	COG0372	Belongs to the citrate synthase family
F5K02_12925	COG1960	acyl-CoA dehydrogenase activity
F5K02_12930	COG1250	3-hydroxyacyl-CoA dehydrogenase
F5K02_12935	COG0183	Belongs to the thiolase family
F5K02_12940	COG0584	glycerophosphoryl diester phosphodiesterase
F5K02_12945	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_12970	COG1902	pentaerythritol trinitrate reductase activity
F5K02_12985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F5K02_12990	COG0745	RESPONSE REGULATOR receiver
F5K02_12995	COG0750	zinc metalloprotease
F5K02_13000	COG0497	DNA recombination
F5K02_13010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F5K02_13020	COG0142	geranyltranstransferase activity
F5K02_13030	COG1570	exodeoxyribonuclease VII activity
F5K02_13045	COG1302	Protein conserved in bacteria
F5K02_13050	COG0439	Biotin carboxylase
F5K02_13055	COG0511	ligase activity, forming carbon-carbon bonds
F5K02_13095	COG3854	ATPases associated with a variety of cellular activities
F5K02_13110	COG0006	proline dipeptidase activity
F5K02_13120	COG3872	metal-dependent enzyme
F5K02_13130	COG1752	Esterase of the alpha-beta hydrolase superfamily
F5K02_13145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F5K02_13165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F5K02_13180	COG1396	sequence-specific DNA binding
F5K02_13190	COG0681	Belongs to the peptidase S26 family
F5K02_13215	COG4940	Competence protein ComGF
F5K02_13225	COG4970	Tfp pilus assembly protein FimT
F5K02_13230	COG4537	Required for transformation and DNA binding
F5K02_13235	COG1459	type II secretion system
F5K02_13240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F5K02_13245	COG0598	Magnesium transport protein CorA
F5K02_13250	COG1253	flavin adenine dinucleotide binding
F5K02_13255	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_13265	COG1393	Belongs to the ArsC family
F5K02_13275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_13285	COG0011	TIGRFAM Protein of
F5K02_13295	COG2866	Carboxypeptidase
F5K02_13300	COG1940	carbohydrate kinase activity
F5K02_13305	COG4483	Protein conserved in bacteria
F5K02_13310	COG1757	Na H antiporter
F5K02_13320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F5K02_13335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F5K02_13340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F5K02_13345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F5K02_13350	COG0581	inorganic phosphate transmembrane transporter activity
F5K02_13355	COG0573	inorganic phosphate transmembrane transporter activity
F5K02_13360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F5K02_13365	COG0768	penicillin binding
F5K02_13370	COG0477	Major facilitator Superfamily
F5K02_13375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F5K02_13380	COG2839	Protein conserved in bacteria
F5K02_13385	COG5521	maltodextrose utilization protein MalA
F5K02_13390	COG1388	LysM domain
F5K02_13400	COG4709	membrane
F5K02_13405	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
F5K02_13410	COG0735	belongs to the Fur family
F5K02_13415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_13430	COG0513	Belongs to the DEAD box helicase family
F5K02_13445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F5K02_13450	COG2384	SAM-dependent methyltransferase
F5K02_13455	COG2010	Cytochrome c
F5K02_13460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F5K02_13465	COG0358	DNA primase activity
F5K02_13480	COG0517	IMP dehydrogenase activity
F5K02_13485	COG0751	glycine-tRNA ligase activity
F5K02_13505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F5K02_13510	COG0295	cytidine deaminase activity
F5K02_13515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F5K02_13525	COG1480	7TM receptor with intracellular HD hydrolase
F5K02_13530	COG1702	phosphate starvation-inducible protein PhoH
F5K02_13535	COG0561	phosphatase activity
F5K02_13550	COG4864	UPF0365 protein
F5K02_13555	COG1030	water channel activity
F5K02_13560	COG1610	YqeY-like protein
F5K02_13570	COG1283	sodium-dependent phosphate transmembrane transporter activity
F5K02_13575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F5K02_13580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F5K02_13610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F5K02_13625	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_13640	COG1466	dna polymerase III delta subunit
F5K02_13655	COG0658	competence protein
F5K02_13655	COG2333	competence protein COMEC
F5K02_13660	COG2131	deaminase
F5K02_13670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F5K02_13675	COG2226	methyltransferase
F5K02_13680	COG0799	negative regulation of ribosome biogenesis
F5K02_13685	COG1713	HD superfamily hydrolase involved in NAD metabolism
F5K02_13695	COG1534	Rna-binding protein
F5K02_13700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F5K02_13705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F5K02_13710	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F5K02_13720	COG2755	lipolytic protein G-D-S-L family
F5K02_13730	COG0398	Pfam SNARE associated Golgi protein
F5K02_13755	COG1794	racemase activity, acting on amino acids and derivatives
F5K02_13765	COG0114	fumarate hydratase activity
F5K02_13775	COG0656	L-ascorbic acid biosynthetic process
F5K02_13805	COG5444	nuclease activity
F5K02_13810	COG4282	regulation of fungal-type cell wall biogenesis
F5K02_13825	COG0583	DNA-binding transcription factor activity
F5K02_13840	COG0642	Histidine kinase
F5K02_13840	COG5002	protein histidine kinase activity
F5K02_13845	COG0745	RESPONSE REGULATOR receiver
F5K02_13850	COG2311	Membrane
F5K02_13860	COG0454	-acetyltransferase
F5K02_13865	COG0563	adenylate kinase activity
F5K02_13880	COG0456	acetyltransferase
F5K02_13885	COG2318	DinB family
F5K02_13895	COG0561	phosphatase activity
F5K02_13900	COG0561	phosphatase activity
F5K02_13910	COG1482	cell wall glycoprotein biosynthetic process
F5K02_13915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5K02_13915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F5K02_13915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_13920	COG3711	transcriptional antiterminator
F5K02_13920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_13930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F5K02_13935	COG0583	DNA-binding transcription factor activity
F5K02_13940	COG2814	Major facilitator Superfamily
F5K02_13945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F5K02_13945	COG2124	cytochrome p450
F5K02_13950	COG1309	transcriptional regulator
F5K02_13955	COG2226	methyltransferase
F5K02_13970	COG2116	formate transmembrane transporter activity
F5K02_13975	COG5609	conserved protein (DUF2294)
F5K02_13980	COG3383	formate dehydrogenase (NAD+) activity
F5K02_13985	COG2427	Protein of unknown function (DUF1641)
F5K02_13995	COG0626	cystathionine gamma-synthase activity
F5K02_14000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F5K02_14025	COG0768	penicillin binding
F5K02_14040	COG0826	peptidase U32
F5K02_14045	COG0826	peptidase U32
F5K02_14050	COG4122	O-methyltransferase activity
F5K02_14055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F5K02_14080	COG0628	permease
F5K02_14085	COG1126	abc transporter atp-binding protein
F5K02_14090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_14095	COG0765	amino acid transport
F5K02_14100	COG0765	amino acid transport
F5K02_14115	COG3881	PFAM PRC-barrel domain
F5K02_14120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F5K02_14125	COG0457	Tetratricopeptide repeat
F5K02_14135	COG1104	cysteine desulfurase activity
F5K02_14140	COG1959	2 iron, 2 sulfur cluster binding
F5K02_14145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F5K02_14150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F5K02_14170	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_14170	COG3103	Sh3 type 3 domain protein
F5K02_14170	COG4991	sh3 domain protein
F5K02_14180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F5K02_14190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F5K02_14190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F5K02_14195	COG5416	Lipopolysaccharide assembly protein A domain
F5K02_14200	COG0490	domain, Protein
F5K02_14205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F5K02_14205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F5K02_14215	COG2244	polysaccharide biosynthetic process
F5K02_14220	COG2323	membrane
F5K02_14230	COG1862	Preprotein translocase
F5K02_14275	COG1388	LysM domain
F5K02_14285	COG0157	Belongs to the NadC ModD family
F5K02_14290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F5K02_14295	COG1104	cysteine desulfurase activity
F5K02_14300	COG1827	regulation of RNA biosynthetic process
F5K02_14305	COG0077	Prephenate dehydratase
F5K02_14320	COG3290	protein histidine kinase activity
F5K02_14325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F5K02_14330	COG2868	ribosomal protein
F5K02_14340	COG1994	Peptidase M50
F5K02_14345	COG0739	heme binding
F5K02_14350	COG2894	cell division
F5K02_14360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F5K02_14370	COG1077	Cell shape determining protein MreB Mrl
F5K02_14390	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F5K02_14395	COG0285	dihydrofolate synthase activity
F5K02_14400	COG0525	valine-tRNA ligase activity
F5K02_14410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F5K02_14415	COG1388	LysM domain
F5K02_14425	COG0113	porphobilinogen synthase activity
F5K02_14430	COG1587	Uroporphyrinogen-III synthase
F5K02_14440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F5K02_14460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F5K02_14465	COG0470	DNA polymerase III
F5K02_14465	COG1067	ATP-dependent peptidase activity
F5K02_14480	COG1477	protein flavinylation
F5K02_14480	COG0457	Tetratricopeptide repeat
F5K02_14495	COG0473	3-isopropylmalate dehydrogenase activity
F5K02_14510	COG0440	acetolactate synthase activity
F5K02_14515	COG0028	Belongs to the TPP enzyme family
F5K02_14545	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
F5K02_14565	COG0622	Phosphoesterase
F5K02_14570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F5K02_14580	COG5401	PFAM Sporulation and spore germination
F5K02_14590	COG1846	Transcriptional regulator
F5K02_14595	COG2197	response regulator
F5K02_14600	COG0824	Thioesterase
F5K02_14605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F5K02_14610	COG1053	succinate dehydrogenase
F5K02_14615	COG2009	succinate dehydrogenase
F5K02_14620	COG1719	4-vinyl reductase, 4VR
F5K02_14625	COG0527	aspartate kinase activity
F5K02_14640	COG3118	belongs to the thioredoxin family
F5K02_14645	COG3534	alpha-L-arabinofuranosidase
F5K02_14650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F5K02_14655	COG2086	electron transfer activity
F5K02_14660	COG1024	Enoyl-CoA hydratase
F5K02_14665	COG1309	transcriptional regulator
F5K02_14670	COG0318	PFAM AMP-dependent synthetase and ligase
F5K02_14680	COG3766	membrane
F5K02_14690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F5K02_14690	COG1796	DNA polymerase
F5K02_14695	COG1286	toxin biosynthetic process
F5K02_14710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5K02_14710	COG0072	phenylalanine-tRNA ligase activity
F5K02_14715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F5K02_14720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F5K02_14730	COG3835	regulator
F5K02_14735	COG0277	FAD linked oxidase domain protein
F5K02_14740	COG0247	lactate metabolic process
F5K02_14745	COG1966	Carbon starvation protein
F5K02_14750	COG3534	alpha-L-arabinofuranosidase
F5K02_14755	COG0395	ABC-type sugar transport system, permease component
F5K02_14760	COG1175	transmembrane transport
F5K02_14765	COG1653	transport
F5K02_14775	COG0647	UMP catabolic process
F5K02_14780	COG0235	Class ii aldolase
F5K02_14785	COG1069	ribulokinase activity
F5K02_14790	COG2160	L-arabinose isomerase activity
F5K02_14795	COG3507	Belongs to the glycosyl hydrolase 43 family
F5K02_14800	COG1363	Peptidase, m42
F5K02_14810	COG3326	Membrane
F5K02_14815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F5K02_14825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F5K02_14830	COG1346	cytolysis
F5K02_14835	COG1380	Effector of murein hydrolase LrgA
F5K02_14840	COG3279	Response regulator of the LytR AlgR family
F5K02_14845	COG3275	phosphorelay sensor kinase activity
F5K02_14850	COG1011	Hydrolase
F5K02_14865	COG0398	Pfam SNARE associated Golgi protein
F5K02_14870	COG1484	DNA-dependent DNA replication
F5K02_14875	COG3611	Membrane attachment protein
F5K02_14890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F5K02_14895	COG1733	regulation of RNA biosynthetic process
F5K02_14900	COG2814	Major facilitator Superfamily
F5K02_14905	COG0656	L-ascorbic acid biosynthetic process
F5K02_14910	COG0237	dephospho-CoA kinase activity
F5K02_14915	COG1971	Probably functions as a manganese efflux pump
F5K02_14920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F5K02_14925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F5K02_14925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F5K02_14930	COG5002	protein histidine kinase activity
F5K02_14935	COG0745	RESPONSE REGULATOR receiver
F5K02_14945	COG0538	isocitrate dehydrogenase activity
F5K02_14950	COG0372	Belongs to the citrate synthase family
F5K02_14965	COG0628	permease
F5K02_14970	COG3030	protein affecting phage T7 exclusion by the F plasmid
F5K02_14975	COG0469	pyruvate kinase activity
F5K02_14995	COG0281	malic enzyme
F5K02_15000	COG0587	DNA-directed DNA polymerase activity
F5K02_15020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F5K02_15030	COG4109	DRTGG domain
F5K02_15040	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_15055	COG0521	Mo-molybdopterin cofactor biosynthetic process
F5K02_15065	COG0827	DNA restriction-modification system
F5K02_15070	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F5K02_15075	COG3874	Sporulation protein YtfJ
F5K02_15085	COG1714	RDD family
F5K02_15090	COG0616	signal peptide processing
F5K02_15095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F5K02_15100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F5K02_15105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F5K02_15120	COG1104	cysteine desulfurase activity
F5K02_15125	COG1114	Component of the transport system for branched-chain amino acids
F5K02_15135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F5K02_15140	COG1309	transcriptional regulator
F5K02_15145	COG1956	GAF domain-containing protein
F5K02_15150	COG2199	diguanylate cyclase activity
F5K02_15150	COG2203	Gaf domain
F5K02_15165	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_15170	COG4282	regulation of fungal-type cell wall biogenesis
F5K02_15200	COG1017	nitric oxide dioxygenase activity
F5K02_15200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F5K02_15215	COG0693	protein deglycase activity
F5K02_15230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F5K02_15235	COG1378	Sugar-specific transcriptional regulator TrmB
F5K02_15255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F5K02_15260	COG0454	-acetyltransferase
F5K02_15265	COG0517	IMP dehydrogenase activity
F5K02_15270	COG0123	including yeast histone deacetylase and acetoin utilization protein
F5K02_15275	COG1360	Flagellar Motor Protein
F5K02_15280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F5K02_15285	COG1609	Transcriptional regulator
F5K02_15290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F5K02_15290	COG1605	Chorismate mutase
F5K02_15295	COG3118	belongs to the thioredoxin family
F5K02_15300	COG4980	gas vesicle protein
F5K02_15305	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F5K02_15315	COG1674	ftsk spoiiie
F5K02_15320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F5K02_15330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_15340	COG1363	Peptidase, m42
F5K02_15345	COG5584	Small secreted protein
F5K02_15350	COG0281	malic enzyme
F5K02_15355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F5K02_15370	COG0510	thiamine kinase activity
F5K02_15375	COG1597	lipid kinase activity
F5K02_15385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F5K02_15390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F5K02_15395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5K02_15400	COG2252	PERMEase
F5K02_15405	COG4473	ABC transporter
F5K02_15410	COG1131	(ABC) transporter
F5K02_15415	COG1349	DNA-binding transcription factor activity
F5K02_15420	COG1187	pseudouridine synthase activity
F5K02_15425	COG2244	polysaccharide biosynthetic process
F5K02_15430	COG2081	HI0933 family
F5K02_15435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F5K02_15445	COG1609	Transcriptional regulator
F5K02_15450	COG1653	transport
F5K02_15455	COG1175	transmembrane transport
F5K02_15460	COG0395	ABC-type sugar transport system, permease component
F5K02_15465	COG1486	melibiose metabolic process
F5K02_15475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F5K02_15490	COG2202	Pas domain
F5K02_15490	COG1366	Belongs to the anti-sigma-factor antagonist family
F5K02_15500	COG2814	Major facilitator Superfamily
F5K02_15505	COG5522	Integral membrane protein (intg_mem_TP0381)
F5K02_15510	COG0577	efflux transmembrane transporter activity
F5K02_15515	COG1136	(ABC) transporter
F5K02_15520	COG2205	protein histidine kinase activity
F5K02_15525	COG0745	RESPONSE REGULATOR receiver
F5K02_15530	COG0577	efflux transmembrane transporter activity
F5K02_15535	COG1136	(ABC) transporter
F5K02_15555	COG1131	(ABC) transporter
F5K02_15560	COG1725	Transcriptional regulator
F5K02_15570	COG0640	Transcriptional regulator
F5K02_15575	COG0477	Major facilitator Superfamily
F5K02_15580	COG1242	4 iron, 4 sulfur cluster binding
F5K02_15585	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F5K02_15595	COG0584	glycerophosphoryl diester phosphodiesterase
F5K02_15605	COG2267	carboxylic ester hydrolase activity
F5K02_15610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F5K02_15615	COG1113	amino acid transport
F5K02_15620	COG0367	asparagine synthase
F5K02_15640	COG1506	peptidase
F5K02_15645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F5K02_15650	COG1116	anion transmembrane transporter activity
F5K02_15655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F5K02_15660	COG0494	nUDIX hydrolase
F5K02_15665	COG4824	toxin secretion phage lysis holin
F5K02_15670	COG0783	Belongs to the Dps family
F5K02_15695	COG0288	reversible hydration of carbon dioxide
F5K02_15705	COG1271	oxidase subunit
F5K02_15710	COG1294	oxidase, subunit
F5K02_15720	COG4948	Mandelate Racemase Muconate Lactonizing
F5K02_15730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F5K02_15735	COG0596	Alpha beta hydrolase
F5K02_15745	COG1169	isochorismate synthase
F5K02_15750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F5K02_15755	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F5K02_15880	COG3859	Proton-coupled thiamine transporter YuaJ
F5K02_15885	COG2268	Band 7 protein
F5K02_15890	COG1585	Membrane protein implicated in regulation of membrane protease activity
F5K02_15895	COG2318	DinB family
F5K02_15905	COG1454	alcohol dehydrogenase
F5K02_15910	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_15915	COG1510	regulation of RNA biosynthetic process
F5K02_15925	COG0569	domain protein
F5K02_15930	COG1705	Flagellar rod assembly protein muramidase FlgJ
F5K02_15935	COG1017	nitric oxide dioxygenase activity
F5K02_15935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F5K02_15955	COG0457	Tetratricopeptide repeat
F5K02_15980	COG0628	permease
F5K02_15985	COG0673	inositol 2-dehydrogenase activity
F5K02_15990	COG0693	protein deglycase activity
F5K02_15995	COG0840	transmembrane signaling receptor activity
F5K02_16000	COG0840	transmembrane signaling receptor activity
F5K02_16005	COG0840	transmembrane signaling receptor activity
F5K02_16010	COG0840	transmembrane signaling receptor activity
F5K02_16025	COG2070	2-Nitropropane dioxygenase
F5K02_16030	COG0432	Pfam Uncharacterised protein family UPF0047
F5K02_16035	COG0366	Alpha amylase catalytic
F5K02_16040	COG1253	flavin adenine dinucleotide binding
F5K02_16045	COG2738	Putative neutral zinc metallopeptidase
F5K02_16060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F5K02_16090	COG1335	isochorismatase
F5K02_16095	COG1979	alcohol dehydrogenase
F5K02_16100	COG1979	alcohol dehydrogenase
F5K02_16105	COG2155	Conserved Protein
F5K02_16110	COG1098	S1 RNA binding domain
F5K02_16115	COG0436	Aminotransferase
F5K02_16120	COG1522	sequence-specific DNA binding
F5K02_16125	COG2267	carboxylic ester hydrolase activity
F5K02_16135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F5K02_16140	COG2205	protein histidine kinase activity
F5K02_16150	COG5018	Exonuclease
F5K02_16155	COG2814	Major facilitator Superfamily
F5K02_16160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5K02_16165	COG3011	Protein conserved in bacteria
F5K02_16175	COG3290	protein histidine kinase activity
F5K02_16180	COG4565	transcriptional regulatory protein
F5K02_16185	COG1744	ABC transporter substrate-binding protein PnrA-like
F5K02_16190	COG3845	ABC transporter
F5K02_16195	COG4603	Belongs to the binding-protein-dependent transport system permease family
F5K02_16200	COG1079	Belongs to the binding-protein-dependent transport system permease family
F5K02_16210	COG2111	Na H antiporter
F5K02_16210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F5K02_16215	COG2111	Na H antiporter
F5K02_16220	COG1006	Multisubunit Na H antiporter MnhC subunit
F5K02_16225	COG0651	ATP synthesis coupled electron transport
F5K02_16230	COG1863	multisubunit Na H antiporter MnhE subunit
F5K02_16235	COG2212	antiporter activity
F5K02_16240	COG1320	monovalent cation:proton antiporter activity
F5K02_16245	COG2050	protein possibly involved in aromatic compounds catabolism
F5K02_16250	COG2197	response regulator
F5K02_16255	COG4585	Histidine kinase
F5K02_16265	COG0142	geranyltranstransferase activity
F5K02_16285	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F5K02_16290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F5K02_16295	COG1335	isochorismatase
F5K02_16300	COG5506	Protein of unknown function (DUF1694)
F5K02_16315	COG0628	permease
F5K02_16325	COG1418	mRNA catabolic process
F5K02_16330	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_16340	COG1511	domain protein
F5K02_16345	COG0433	COG0433 Predicted ATPase
F5K02_16345	COG1674	ftsk spoiiie
F5K02_16350	COG4499	WXG100 protein secretion system (Wss), protein YukC
F5K02_16355	COG5417	Belongs to the EsaB family
F5K02_16360	COG4842	Belongs to the WXG100 family
F5K02_16365	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F5K02_16365	COG2508	Transcriptional regulator
F5K02_16370	COG0686	Belongs to the AlaDH PNT family
F5K02_16375	COG5634	Uncharacterized conserved protein (DUF2278)
F5K02_16380	COG3251	PFAM MbtH domain protein
F5K02_16385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F5K02_16390	COG1535	isochorismatase
F5K02_16390	COG3433	isochorismatase activity
F5K02_16395	COG1021	2,3-dihydroxybenzoate-AMP ligase
F5K02_16400	COG1169	isochorismate synthase
F5K02_16405	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_16410	COG2819	hydrolase of the alpha beta superfamily
F5K02_16415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F5K02_16420	COG1268	BioY protein
F5K02_16425	COG2056	Na+-H+ antiporter family
F5K02_16435	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
F5K02_16440	COG3584	3D domain protein
F5K02_16455	COG1252	NADH dehydrogenase
F5K02_16485	COG1131	(ABC) transporter
F5K02_16510	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
F5K02_16515	COG0316	Belongs to the HesB IscA family
F5K02_16525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F5K02_16535	COG1252	NADH dehydrogenase
F5K02_16540	COG4837	Protein of unknown function (DUF1462)
F5K02_16545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F5K02_16550	COG0823	Involved in the tonB-independent uptake of proteins
F5K02_16550	COG1506	peptidase
F5K02_16550	COG4946	Tricorn protease homolog
F5K02_16560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F5K02_16565	COG0460	homoserine dehydrogenase
F5K02_16570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F5K02_16575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F5K02_16580	COG0647	UMP catabolic process
F5K02_16585	COG2445	Protein of unknown function DUF86
F5K02_16590	COG4470	Protein conserved in bacteria
F5K02_16605	COG0739	heme binding
F5K02_16615	COG0737	Belongs to the 5'-nucleotidase family
F5K02_16620	COG0730	response to heat
F5K02_16625	COG1801	Protein of unknown function DUF72
F5K02_16640	COG2508	Transcriptional regulator
F5K02_16645	COG0457	Tetratricopeptide repeat
F5K02_16660	COG2814	Major facilitator Superfamily
F5K02_16665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F5K02_16670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F5K02_16675	COG2356	endonuclease I
F5K02_16680	COG3842	ATPase activity
F5K02_16685	COG2188	Transcriptional regulator
F5K02_16690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F5K02_16695	COG0395	ABC-type sugar transport system, permease component
F5K02_16700	COG1175	transmembrane transport
F5K02_16705	COG1653	transport
F5K02_16710	COG2222	sugar isomerase
F5K02_16715	COG0789	Transcriptional regulator
F5K02_16730	COG0322	excinuclease ABC activity
F5K02_16735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F5K02_16740	COG2226	methyltransferase
F5K02_16755	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_16760	COG0719	Fe-S assembly protein
F5K02_16765	COG0822	iron-sulfur transferase activity
F5K02_16770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F5K02_16775	COG0719	Fe-S assembly protein
F5K02_16780	COG0396	ATPase activity
F5K02_16790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F5K02_16795	COG1464	Belongs to the NlpA lipoprotein family
F5K02_16800	COG2011	ABC-type metal ion transport system permease component
F5K02_16805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F5K02_16815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F5K02_16820	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F5K02_16835	COG1393	Belongs to the ArsC family
F5K02_16840	COG1960	acyl-CoA dehydrogenase activity
F5K02_16845	COG0183	Belongs to the thiolase family
F5K02_16850	COG1024	Enoyl-CoA hydratase
F5K02_16850	COG1250	3-hydroxyacyl-CoA dehydrogenase
F5K02_16865	COG0477	Major facilitator Superfamily
F5K02_16875	COG5577	PFAM Coat F domain
F5K02_16880	COG1846	Transcriptional regulator
F5K02_16885	COG0477	Major facilitator Superfamily
F5K02_16890	COG1942	4-Oxalocrotonate Tautomerase
F5K02_16895	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_16900	COG0583	DNA-binding transcription factor activity
F5K02_16915	COG0583	DNA-binding transcription factor activity
F5K02_16935	COG1120	ATPase activity
F5K02_16950	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_16955	COG0783	Belongs to the Dps family
F5K02_16960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F5K02_16970	COG0745	RESPONSE REGULATOR receiver
F5K02_16975	COG2205	protein histidine kinase activity
F5K02_16975	COG2770	Histidine kinase
F5K02_16985	COG1309	transcriptional regulator
F5K02_16990	COG0114	fumarate hydratase activity
F5K02_17000	COG0697	spore germination
F5K02_17005	COG0814	amino acid
F5K02_17015	COG2197	response regulator
F5K02_17020	COG4585	Histidine kinase
F5K02_17025	COG4758	membrane
F5K02_17030	COG3595	metallopeptidase activity
F5K02_17035	COG1842	Phage shock protein A
F5K02_17040	COG4758	membrane
F5K02_17045	COG2814	Major facilitator Superfamily
F5K02_17050	COG2096	Adenosyltransferase
F5K02_17055	COG1120	ATPase activity
F5K02_17060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_17065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F5K02_17070	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_17075	COG3386	PFAM SMP-30 Gluconolaconase
F5K02_17080	COG2205	protein histidine kinase activity
F5K02_17085	COG0745	RESPONSE REGULATOR receiver
F5K02_17095	COG1191	sigma factor activity
F5K02_17105	COG2140	Oxalate decarboxylase
F5K02_17115	COG1120	ATPase activity
F5K02_17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_17125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_17130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F5K02_17135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F5K02_17140	COG0531	amino acid
F5K02_17155	COG1988	membrane-bound metal-dependent
F5K02_17160	COG1368	sulfuric ester hydrolase activity
F5K02_17165	COG1910	domain protein
F5K02_17170	COG0725	ABC transporter, periplasmic molybdate-binding protein
F5K02_17175	COG4149	molybdate abc transporter
F5K02_17180	COG2197	response regulator
F5K02_17185	COG3850	Histidine kinase
F5K02_17190	COG1131	(ABC) transporter
F5K02_17200	COG0842	Transport permease protein
F5K02_17205	COG0656	L-ascorbic acid biosynthetic process
F5K02_17230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F5K02_17235	COG3973	AAA domain
F5K02_17240	COG2860	membrane
F5K02_17250	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F5K02_17255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F5K02_17260	COG2217	Heavy metal translocating P-type atpase
F5K02_17265	COG2217	Heavy metal translocating P-type atpase
F5K02_17270	COG2608	mercury ion transmembrane transporter activity
F5K02_17275	COG1937	Protein conserved in bacteria
F5K02_17280	COG0673	inositol 2-dehydrogenase activity
F5K02_17300	COG2814	Major facilitator Superfamily
F5K02_17315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_17320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F5K02_17325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_17330	COG1126	abc transporter atp-binding protein
F5K02_17335	COG0765	amino acid transport
F5K02_17340	COG0765	amino acid transport
F5K02_17345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_17350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F5K02_17355	COG0454	-acetyltransferase
F5K02_17360	COG0583	DNA-binding transcription factor activity
F5K02_17365	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_17370	COG2732	(Barnase) inhibitor
F5K02_17375	COG2732	(Barnase) inhibitor
F5K02_17390	COG0557	exoribonuclease II activity
F5K02_17395	COG1647	Serine aminopeptidase, S33
F5K02_17400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F5K02_17405	COG1476	TRANSCRIPTIONal
F5K02_17410	COG1396	sequence-specific DNA binding
F5K02_17415	COG1396	sequence-specific DNA binding
F5K02_17420	COG1733	regulation of RNA biosynthetic process
F5K02_17445	COG1131	(ABC) transporter
F5K02_17450	COG1174	glycine betaine transport
F5K02_17455	COG1732	Glycine betaine
F5K02_17460	COG1174	glycine betaine transport
F5K02_17465	COG0517	IMP dehydrogenase activity
F5K02_17465	COG1125	glycine betaine transport
F5K02_17475	COG1174	glycine betaine transport
F5K02_17480	COG1732	Glycine betaine
F5K02_17485	COG1174	glycine betaine transport
F5K02_17490	COG1125	glycine betaine transport
F5K02_17490	COG0517	IMP dehydrogenase activity
F5K02_17495	COG1510	regulation of RNA biosynthetic process
F5K02_17500	COG2095	MarC family integral membrane protein
F5K02_17510	COG3064	Membrane
F5K02_17515	COG4640	response to antibiotic
F5K02_17520	COG0456	acetyltransferase
F5K02_17535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F5K02_17555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F5K02_17560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F5K02_17570	COG2234	aminopeptidase activity
F5K02_17590	COG0126	phosphoglycerate kinase activity
F5K02_17600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F5K02_17605	COG2390	Transcriptional regulator
F5K02_17610	COG2814	Major facilitator Superfamily
F5K02_17615	COG1609	Transcriptional regulator
F5K02_17620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_17630	COG0583	DNA-binding transcription factor activity
F5K02_17635	COG0697	spore germination
F5K02_17640	COG1113	amino acid transport
F5K02_17650	COG1609	Transcriptional regulator
F5K02_17660	COG0561	phosphatase activity
F5K02_17665	COG1737	Transcriptional regulator
F5K02_17670	COG1070	Carbohydrate kinase
F5K02_17695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_17700	COG2186	Transcriptional regulator
F5K02_17705	COG1620	l-lactate permease
F5K02_17710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F5K02_17720	COG5039	Polysaccharide pyruvyl transferase
F5K02_17725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F5K02_17730	COG0110	maltose O-acetyltransferase activity
F5K02_17735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F5K02_17740	COG2244	polysaccharide biosynthetic process
F5K02_17745	COG1216	Glycosyl transferase, family 2
F5K02_17750	COG5039	Polysaccharide pyruvyl transferase
F5K02_17755	COG1216	Glycosyl transferase, family 2
F5K02_17765	COG0438	transferase activity, transferring glycosyl groups
F5K02_17770	COG1215	transferase activity, transferring glycosyl groups
F5K02_17775	COG0438	transferase activity, transferring glycosyl groups
F5K02_17780	COG1086	Polysaccharide biosynthesis protein
F5K02_17785	COG0489	protein tyrosine kinase activity
F5K02_17790	COG3944	biosynthesis protein
F5K02_17795	COG1396	sequence-specific DNA binding
F5K02_17800	COG2272	Belongs to the type-B carboxylesterase lipase family
F5K02_17805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F5K02_17810	COG2364	Membrane
F5K02_17815	COG0456	acetyltransferase
F5K02_17820	COG3479	Phenolic acid decarboxylase
F5K02_17870	COG1357	PFAM Pentapeptide repeats (8 copies)
F5K02_17895	COG2223	nitrite transmembrane transporter activity
F5K02_17900	COG1609	Transcriptional regulator
F5K02_17910	COG0583	DNA-binding transcription factor activity
F5K02_17915	COG2828	Protein conserved in bacteria
F5K02_17920	COG0477	Major facilitator Superfamily
F5K02_17920	COG2814	Major facilitator Superfamily
F5K02_17925	COG1611	Belongs to the LOG family
F5K02_17930	COG1694	Mazg nucleotide pyrophosphohydrolase
F5K02_17935	COG0659	secondary active sulfate transmembrane transporter activity
F5K02_17940	COG0288	reversible hydration of carbon dioxide
F5K02_17950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F5K02_17955	COG4290	ribonuclease
F5K02_17960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
F5K02_17965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_17975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F5K02_17985	COG1051	belongs to the nudix hydrolase family
F5K02_17990	COG0492	ferredoxin-NADP+ reductase activity
F5K02_17995	COG0791	NLP P60 protein
F5K02_17995	COG3883	PFAM NLP P60 protein
F5K02_18000	COG0457	Tetratricopeptide repeat
F5K02_18005	COG5002	protein histidine kinase activity
F5K02_18010	COG0745	RESPONSE REGULATOR receiver
F5K02_18015	COG1132	(ABC) transporter
F5K02_18020	COG0140	phosphoribosyl-ATP diphosphatase activity
F5K02_18020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F5K02_18045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F5K02_18060	COG4990	cell redox homeostasis
F5K02_18065	COG0110	maltose O-acetyltransferase activity
F5K02_18085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F5K02_18095	COG2188	Transcriptional regulator
F5K02_18100	COG1309	transcriptional regulator
F5K02_18105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F5K02_18110	COG1950	PFAM Membrane protein of
F5K02_18115	COG1983	PspC domain protein
F5K02_18120	COG3595	metallopeptidase activity
F5K02_18135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F5K02_18145	COG4897	Protein conserved in bacteria
F5K02_18150	COG3848	Pyruvate phosphate dikinase
F5K02_18150	COG0574	Belongs to the PEP-utilizing enzyme family
F5K02_18155	COG1309	transcriptional regulator
F5K02_18160	COG2814	Major facilitator Superfamily
F5K02_18170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F5K02_18180	COG0793	Belongs to the peptidase S41A family
F5K02_18180	COG3409	Peptidoglycan-binding domain 1 protein
F5K02_18185	COG3420	alginic acid biosynthetic process
F5K02_18190	COG2177	Part of the ABC transporter FtsEX involved in
F5K02_18195	COG2884	Cell division ATP-binding protein ftsE
F5K02_18200	COG2010	Cytochrome c
F5K02_18205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_18220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F5K02_18235	COG1516	flagellar protein fliS
F5K02_18240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F5K02_18245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F5K02_18265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F5K02_18270	COG4786	Flagellar basal body rod
F5K02_18270	COG1256	bacterial-type flagellum assembly
F5K02_18275	COG3418	PFAM FlgN family protein
F5K02_18280	COG2747	anti-sigma28 factor FlgM
F5K02_18290	COG1040	competence protein
F5K02_18300	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F5K02_18305	COG1307	EDD domain protein, DegV family
F5K02_18310	COG2197	response regulator
F5K02_18315	COG4585	Histidine kinase
F5K02_18320	COG1739	Uncharacterized protein family UPF0029
F5K02_18325	COG1316	TRANSCRIPTIONal
F5K02_18330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F5K02_18335	COG0438	transferase activity, transferring glycosyl groups
F5K02_18340	COG1215	transferase activity, transferring glycosyl groups
F5K02_18345	COG3206	protein involved in exopolysaccharide biosynthesis
F5K02_18350	COG3307	-O-antigen
F5K02_18355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F5K02_18360	COG0297	glycogen (starch) synthase activity
F5K02_18360	COG0438	transferase activity, transferring glycosyl groups
F5K02_18365	COG2244	polysaccharide biosynthetic process
F5K02_18375	COG0860	N-Acetylmuramoyl-L-alanine amidase
F5K02_18375	COG2247	cell wall binding repeat
F5K02_18380	COG2247	cell wall binding repeat
F5K02_18380	COG2385	sporulation resulting in formation of a cellular spore
F5K02_18390	COG1316	TRANSCRIPTIONal
F5K02_18395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F5K02_18400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F5K02_18405	COG1134	teichoic acid transport
F5K02_18410	COG1682	transport, permease protein
F5K02_18415	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F5K02_18420	COG0438	transferase activity, transferring glycosyl groups
F5K02_18425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F5K02_18430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
F5K02_18435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F5K02_18440	COG4193	domain, Protein
F5K02_18445	COG1482	cell wall glycoprotein biosynthetic process
F5K02_18450	COG0697	spore germination
F5K02_18455	COG0814	amino acid
F5K02_18465	COG1215	transferase activity, transferring glycosyl groups
F5K02_18470	COG2814	Major facilitator Superfamily
F5K02_18475	COG1316	TRANSCRIPTIONal
F5K02_18480	COG0561	phosphatase activity
F5K02_18485	COG2433	Pfam Transposase IS66
F5K02_18490	COG0791	NLP P60 protein
F5K02_18500	COG2843	Capsule synthesis protein
F5K02_18510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F5K02_18520	COG0697	spore germination
F5K02_18525	COG0814	amino acid
F5K02_18535	COG1609	Transcriptional regulator
F5K02_18540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F5K02_18550	COG1129	ABC transporter
F5K02_18555	COG1172	Belongs to the binding-protein-dependent transport system permease family
F5K02_18560	COG1879	ABC-type sugar transport system periplasmic component
F5K02_18565	COG3103	Sh3 type 3 domain protein
F5K02_18570	COG2249	NAD(P)H dehydrogenase (quinone) activity
F5K02_18575	COG3527	Alpha-acetolactate decarboxylase
F5K02_18580	COG0028	Belongs to the TPP enzyme family
F5K02_18585	COG0583	DNA-binding transcription factor activity
F5K02_18590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F5K02_18605	COG5337	Spore coat protein CotH
F5K02_18615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F5K02_18625	COG0405	Gamma-glutamyltransferase
F5K02_18630	COG1522	sequence-specific DNA binding
F5K02_18635	COG2059	Chromate
F5K02_18640	COG2059	Chromate
F5K02_18665	COG5444	nuclease activity
F5K02_18680	COG3878	Protein conserved in bacteria
F5K02_18685	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F5K02_18690	COG4464	protein tyrosine phosphatase activity
F5K02_18695	COG0489	protein tyrosine kinase activity
F5K02_18700	COG3944	biosynthesis protein
F5K02_18715	COG4715	Zinc finger, swim domain protein
F5K02_18720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F5K02_18725	COG0561	phosphatase activity
F5K02_18730	COG1349	DNA-binding transcription factor activity
F5K02_18735	COG0629	single-stranded DNA binding
F5K02_18760	COG0457	Tetratricopeptide repeat
F5K02_18765	COG4786	Flagellar basal body rod
F5K02_18770	COG4786	Flagellar basal body rod
F5K02_18775	COG1077	Cell shape determining protein MreB Mrl
F5K02_18780	COG1609	Transcriptional regulator
F5K02_18785	COG1846	Transcriptional regulator
F5K02_18790	COG2814	Major facilitator Superfamily
F5K02_18795	COG1953	Uracil, thiamine, allantoin
F5K02_18800	COG0477	Major facilitator Superfamily
F5K02_18805	COG1335	isochorismatase
F5K02_18810	COG0004	ammonium transporteR
F5K02_18815	COG0347	Belongs to the P(II) protein family
F5K02_18820	COG0772	Belongs to the SEDS family
F5K02_18825	COG0671	phosphoesterase, PA-phosphatase related
F5K02_18835	COG0739	heme binding
F5K02_18840	COG1247	-acetyltransferase
F5K02_18855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F5K02_18865	COG0726	polysaccharide deacetylase
F5K02_18875	COG1959	2 iron, 2 sulfur cluster binding
F5K02_18890	COG0831	urea catabolic process
F5K02_18900	COG1994	Peptidase M50
F5K02_18905	COG0457	Tetratricopeptide repeat
F5K02_18915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F5K02_18920	COG2304	oxidoreductase activity
F5K02_18925	COG2304	oxidoreductase activity
F5K02_18930	COG2385	sporulation resulting in formation of a cellular spore
F5K02_18935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F5K02_18945	COG4836	Membrane
F5K02_19015	COG0698	ribose 5-phosphate isomerase
F5K02_19020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F5K02_19030	COG0009	L-threonylcarbamoyladenylate synthase
F5K02_19035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F5K02_19055	COG2890	protein-(glutamine-N5) methyltransferase activity
F5K02_19060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F5K02_19065	COG0346	lactoylglutathione lyase activity
F5K02_19070	COG0789	Transcriptional regulator
F5K02_19075	COG0679	Auxin Efflux Carrier
F5K02_19080	COG0281	malic enzyme
F5K02_19095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F5K02_19100	COG1494	fructose-1,6-bisphosphatase
F5K02_19105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F5K02_19115	COG0191	fructose-bisphosphate aldolase activity
F5K02_19120	COG2204	response regulator
F5K02_19125	COG4821	SIS domain
F5K02_19140	COG2181	nitrate reductase activity
F5K02_19140	COG0247	lactate metabolic process
F5K02_19145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F5K02_19160	COG1132	(ABC) transporter
F5K02_19165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F5K02_19175	COG2181	nitrate reductase activity
F5K02_19180	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F5K02_19185	COG1140	nitrate reductase beta subunit
F5K02_19190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F5K02_19195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F5K02_19205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F5K02_19210	COG2223	nitrite transmembrane transporter activity
F5K02_19220	COG4506	Protein conserved in bacteria
F5K02_19230	COG3391	amine dehydrogenase activity
F5K02_19235	COG3391	amine dehydrogenase activity
F5K02_19245	COG0457	Tetratricopeptide repeat
F5K02_19290	COG0010	Belongs to the arginase family
F5K02_19295	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F5K02_19300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F5K02_19315	COG1994	Peptidase M50
F5K02_19320	COG1942	4-Oxalocrotonate Tautomerase
F5K02_19325	COG1846	Transcriptional regulator
F5K02_19335	COG0531	amino acid
F5K02_19340	COG3465	dGTPase activity
F5K02_19345	COG1078	dGTPase activity
F5K02_19360	COG1695	Transcriptional regulator
F5K02_19370	COG1131	(ABC) transporter
F5K02_19375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F5K02_19405	COG0583	DNA-binding transcription factor activity
F5K02_19410	COG2855	membrane
F5K02_19415	COG0280	phosphate acetyltransferase
F5K02_19425	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_19430	COG0436	Aminotransferase
F5K02_19460	COG2814	Major facilitator Superfamily
F5K02_19465	COG2814	Major facilitator Superfamily
F5K02_19470	COG0833	amino acid
F5K02_19475	COG4187	Peptidase family M20/M25/M40
F5K02_19480	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_19485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F5K02_19495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F5K02_19500	COG1091	dTDP-4-dehydrorhamnose reductase activity
F5K02_19505	COG1088	dTDP-glucose 4,6-dehydratase activity
F5K02_19510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F5K02_19515	COG3980	spore coat polysaccharide biosynthesis protein
F5K02_19520	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
F5K02_19525	COG2089	acid synthase
F5K02_19530	COG0456	acetyltransferase
F5K02_19535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F5K02_19540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F5K02_19545	COG0463	Glycosyl transferase, family 2
F5K02_19555	COG2363	Small membrane protein
F5K02_19560	COG2233	PERMEase
F5K02_19575	COG1216	Glycosyl transferase, family 2
F5K02_19590	COG1695	Transcriptional regulator
F5K02_19595	COG0351	phosphomethylpyrimidine kinase
F5K02_19605	COG1621	beta-fructofuranosidase activity
F5K02_19610	COG1263	PTS System
F5K02_19610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_19615	COG3711	transcriptional antiterminator
F5K02_19625	COG1404	Belongs to the peptidase S8 family
F5K02_19630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F5K02_19635	COG0778	Nitroreductase
F5K02_19640	COG0772	Belongs to the SEDS family
F5K02_19645	COG0454	-acetyltransferase
F5K02_19665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F5K02_19670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F5K02_19675	COG2261	transglycosylase associated protein
F5K02_19680	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F5K02_19685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F5K02_19690	COG2246	polysaccharide biosynthetic process
F5K02_19695	COG1309	transcriptional regulator
F5K02_19715	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F5K02_19720	COG2837	iron assimilation
F5K02_19725	COG2822	iron ion transport
F5K02_19740	COG0583	DNA-binding transcription factor activity
F5K02_19750	COG1346	cytolysis
F5K02_19755	COG4895	conserved protein (DUF2196)
F5K02_19760	COG0789	Transcriptional regulator
F5K02_19765	COG5504	Zn-dependent protease
F5K02_19770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F5K02_19775	COG0346	lactoylglutathione lyase activity
F5K02_19780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_19785	COG1404	Belongs to the peptidase S8 family
F5K02_19790	COG1442	glycosyl transferase family 8
F5K02_19795	COG2357	RelA SpoT domain protein
F5K02_19800	COG1575	Belongs to the MenA family. Type 1 subfamily
F5K02_19825	COG1696	Membrane protein involved in D-alanine export
F5K02_19835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F5K02_19840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F5K02_19845	COG1486	melibiose metabolic process
F5K02_19850	COG1447	Phosphotransferase system cellobiose-specific component IIA
F5K02_19855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_19860	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_19865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F5K02_19865	COG3711	transcriptional antiterminator
F5K02_19880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_19885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F5K02_19895	COG0640	Transcriptional regulator
F5K02_19900	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F5K02_19905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_19910	COG1447	Phosphotransferase system cellobiose-specific component IIA
F5K02_19915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F5K02_19920	COG2723	6-phospho-beta-galactosidase activity
F5K02_19925	COG1940	carbohydrate kinase activity
F5K02_19930	COG1482	cell wall glycoprotein biosynthetic process
F5K02_19940	COG0753	catalase activity
F5K02_19945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F5K02_19950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F5K02_19955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F5K02_19960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F5K02_19965	COG4988	ABC transporter
F5K02_19970	COG1294	oxidase, subunit
F5K02_19975	COG1271	oxidase subunit
F5K02_19980	COG3493	citrate carrier protein
F5K02_19985	COG0726	polysaccharide deacetylase
F5K02_19990	COG3842	ATPase activity
F5K02_19995	COG2508	Transcriptional regulator
F5K02_20000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_20010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F5K02_20020	COG4894	glucomannan catabolic process
F5K02_20025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F5K02_20030	COG0500	methyltransferase
F5K02_20035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F5K02_20050	COG0753	catalase activity
F5K02_20050	COG0693	protein deglycase activity
F5K02_20055	COG2851	Citrate transporter
F5K02_20060	COG2273	Hydrolase Family 16
F5K02_20065	COG3711	transcriptional antiterminator
F5K02_20070	COG2270	Major facilitator Superfamily
F5K02_20075	COG0513	Belongs to the DEAD box helicase family
F5K02_20170	COG3209	COG3209 Rhs family protein
F5K02_20180	COG0697	spore germination
F5K02_20185	COG0589	response to stress
F5K02_20190	COG2723	6-phospho-beta-galactosidase activity
F5K02_20195	COG1263	PTS System
F5K02_20195	COG2190	(PTS) system
F5K02_20195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F5K02_20210	COG3507	Belongs to the glycosyl hydrolase 43 family
F5K02_20235	COG0010	Belongs to the arginase family
F5K02_20240	COG0833	amino acid
F5K02_20245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F5K02_20250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F5K02_20260	COG2390	Transcriptional regulator
F5K02_20265	COG0561	phosphatase activity
F5K02_20295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F5K02_20300	COG5294	Protein conserved in bacteria
F5K02_20305	COG0577	efflux transmembrane transporter activity
F5K02_20310	COG1136	(ABC) transporter
F5K02_20315	COG2205	protein histidine kinase activity
F5K02_20320	COG0745	RESPONSE REGULATOR receiver
F5K02_20335	COG1082	Xylose isomerase domain protein TIM barrel
F5K02_20345	COG2814	Major facilitator Superfamily
F5K02_20375	COG1349	DNA-binding transcription factor activity
F5K02_20380	COG0667	Aldo Keto reductase
F5K02_20390	COG2814	Major facilitator Superfamily
F5K02_20405	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_20410	COG2197	response regulator
F5K02_20415	COG4585	Histidine kinase
F5K02_20420	COG3239	Fatty acid desaturase
F5K02_20430	COG1309	transcriptional regulator
F5K02_20435	COG1012	belongs to the aldehyde dehydrogenase family
F5K02_20440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F5K02_20450	COG0640	Transcriptional regulator
F5K02_20455	COG2814	Major facilitator Superfamily
F5K02_20460	COG1714	RDD family
F5K02_20470	COG0450	alkyl hydroperoxide reductase
F5K02_20475	COG3634	alkyl hydroperoxide reductase activity
F5K02_20480	COG3177	Filamentation induced by cAMP protein fic
F5K02_20485	COG1113	amino acid transport
F5K02_20495	COG2080	2 iron, 2 sulfur cluster binding
F5K02_20510	COG2068	MobA-Related Protein
F5K02_20515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F5K02_20590	COG2003	Belongs to the UPF0758 family
F5K02_20630	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
F5K02_20635	COG0667	Aldo Keto reductase
F5K02_20640	COG0456	acetyltransferase
F5K02_20645	COG0457	Tetratricopeptide repeat
F5K02_20650	COG0010	Belongs to the arginase family
F5K02_20655	COG0833	amino acid
F5K02_20660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F5K02_20665	COG5658	integral membrane protein
F5K02_20670	COG0640	Transcriptional regulator
F5K02_20675	COG3829	transcription factor binding
F5K02_20685	COG0488	(ABC) transporter
F5K02_20700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F5K02_20705	COG3850	Histidine kinase
F5K02_20705	COG5002	protein histidine kinase activity
F5K02_20710	COG0745	RESPONSE REGULATOR receiver
F5K02_20715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F5K02_20720	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F5K02_20725	COG4853	Protein conserved in bacteria
F5K02_20730	COG4863	YycH protein
F5K02_20735	COG5002	protein histidine kinase activity
F5K02_20740	COG0745	RESPONSE REGULATOR receiver
F5K02_20775	COG0346	lactoylglutathione lyase activity
F5K02_20780	COG0305	Participates in initiation and elongation during chromosome replication
F5K02_20800	COG3093	addiction module antidote protein HigA
F5K02_20805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F5K02_20820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F5K02_20825	COG0438	transferase activity, transferring glycosyl groups
F5K02_20845	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
F5K02_20850	COG4241	membrane
F5K02_20860	COG5577	PFAM Coat F domain
F5K02_20865	COG1733	regulation of RNA biosynthetic process
F5K02_20875	COG0697	spore germination
F5K02_20880	COG1621	beta-fructofuranosidase activity
F5K02_20885	COG1621	beta-fructofuranosidase activity
F5K02_20890	COG1802	Transcriptional regulator
F5K02_20895	COG2318	DinB family
F5K02_20900	COG2211	Major facilitator Superfamily
F5K02_20905	COG0583	DNA-binding transcription factor activity
F5K02_20920	COG0778	Nitroreductase
F5K02_20925	COG1846	Transcriptional regulator
F5K02_20930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F5K02_20935	COG1846	Transcriptional regulator
F5K02_20940	COG2153	protein acetylation
F5K02_20950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F5K02_20955	COG0583	DNA-binding transcription factor activity
F5K02_20960	COG1028	Short-chain dehydrogenase reductase Sdr
F5K02_20965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F5K02_20970	COG0697	spore germination
F5K02_20975	COG1331	Highly conserved protein containing a thioredoxin domain
F5K02_20980	COG1266	CAAX protease self-immunity
F5K02_20985	COG2814	Major facilitator Superfamily
F5K02_20985	COG0477	Major facilitator Superfamily
F5K02_20990	COG0346	lactoylglutathione lyase activity
F5K02_20995	COG1609	Transcriptional regulator
F5K02_21000	COG0708	Exodeoxyribonuclease III
F5K02_21005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F5K02_21010	COG2169	Transcriptional regulator
F5K02_21020	COG0629	single-stranded DNA binding
F5K02_21030	COG0012	GTP binding
F5K02_21035	COG0243	molybdopterin cofactor binding
F5K02_21040	COG4481	Protein conserved in bacteria
F5K02_21045	COG3949	Membrane
F5K02_21060	COG1475	DNA binding
F5K02_21065	COG1192	Involved in chromosome partitioning
F5K02_21090	COG1847	R3H domain protein
F5K02_21095	COG0706	membrane insertase activity