locus-tag class description DIR45_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DIR45_00015 ENOG410848D S4 domain protein YaaA DIR45_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DIR45_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DIR45_00100 ENOG4105ZMH deoxynucleoside kinase DIR45_00110 ENOG4105GTG Isochorismatase DIR45_00120 ENOG4108Z6B deaminase DIR45_00130 ENOG4105C6E dna polymerase iii DIR45_00150 ENOG41067KS pro-sigma K processing DIR45_00185 ENOG4105CXN decarboxylase DIR45_00195 ENOG4105FA2 dna polymerase iii DIR45_00200 ENOG4105MA4 psp1 domain protein DIR45_00210 ENOG41060K3 Methyltransferase DIR45_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DIR45_00225 ENOG4105KRN Transcriptional regulator, abrb family DIR45_00235 ENOG4105F8V Hydrolase, tatD family DIR45_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DIR45_00250 ENOG4105XFA sporulation peptidase YabG DIR45_00255 ENOG4105W42 Veg protein DIR45_00270 ENOG4105DFT pur operon repressor DIR45_00280 ENOG4105KME endoribonuclease L-psp DIR45_00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DIR45_00300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DIR45_00310 ENOG4108JA2 transcriptioN-repair coupling factor DIR45_00315 ENOG4108M14 stage v sporulation protein t DIR45_00325 ENOG4108IY2 MazG family DIR45_00330 ENOG41082I2 s4 domain protein DIR45_00335 ENOG4105VYY sporulation protein yabp DIR45_00350 ENOG41060GV RNA binding s1 domain protein DIR45_00370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DIR45_00375 ENOG4108UGV hypoxanthine phosphoribosyltransferase DIR45_00380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DIR45_00395 ENOG4105C6T cysteine synthase DIR45_00400 ENOG4105CRQ synthase (Component I) DIR45_00405 ENOG4105DDQ anthranilate synthase DIR45_00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DIR45_00415 ENOG4105EEI dihydropteroate synthase DIR45_00420 ENOG4105KRF dihydroneopterin aldolase DIR45_00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DIR45_00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DIR45_00465 ENOG4108Z0C Uvrb UvrC protein DIR45_00480 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DIR45_00490 ENOG4105CTP PilT protein domain protein DIR45_00510 ENOG4105D7W serine acetyltransferase DIR45_00525 ENOG4105C2N RNA methyltransferase TrmH family group 3 DIR45_00530 ENOG4105M0M Tetracycline resistance protein DIR45_00535 ENOG4105QIV RNA polymerase DIR45_00550 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DIR45_00575 ENOG4107Y49 methyltransferase DIR45_00585 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DIR45_00590 ENOG4105XPM ribosomal protein DIR45_00695 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DIR45_00720 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DIR45_00730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DIR45_00740 ENOG41067V7 50S ribosomal protein L36 DIR45_00770 ENOG4108JJB ABC transporter DIR45_00775 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DIR45_00780 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DIR45_00805 ENOG4105D1F ATP-binding protein DIR45_00820 ENOG4108NMV polysaccharide deacetylase DIR45_00905 ENOG4105C8B TIGR00159 family DIR45_00910 ENOG4107U5W ybbr family DIR45_00925 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DIR45_00930 ENOG4108VQT Alpha beta hydrolase fold protein DIR45_00940 ENOG4105CMG Carbohydrate kinase DIR45_00950 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DIR45_00960 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DIR45_00995 ENOG4108UMI ABC transporter, permease DIR45_01000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DIR45_01005 ENOG4105D01 (LipO)protein DIR45_01010 ENOG4105EE1 crotonyl-CoA reductase DIR45_01035 ENOG4105C2C drug resistance transporter, Bcr CflA DIR45_01050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DIR45_01055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DIR45_01060 ENOG4105C3U ABC transporter DIR45_01065 ENOG4108JQ7 (ABC) transporter DIR45_01095 ENOG4108J59 Extracellular solute-binding protein, family 5 DIR45_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 DIR45_01110 ENOG4105II7 pyrroline-5-carboxylate reductase DIR45_01120 ENOG4107XDY Nicotinamide Mononucleotide Transporter DIR45_01130 ENOG4105E0C molybdate abc transporter DIR45_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DIR45_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DIR45_01155 ENOG4105EGI Transcriptional regulator DIR45_01175 ENOG4105F6E Acyl-transferase DIR45_01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DIR45_01215 ENOG4108RE7 deoxyribonuclease DIR45_01220 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DIR45_01245 ENOG4105C5H ABC transporter DIR45_01260 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DIR45_01270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DIR45_01275 ENOG4105C3U ABC transporter DIR45_01280 ENOG4108JQ7 (ABC) transporter DIR45_01315 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DIR45_01320 ENOG4105ERH Fumarylacetoacetate hydrolase DIR45_01335 ENOG4108SC4 )-transporter DIR45_01345 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DIR45_01360 ENOG4107ZXI Rhomboid family DIR45_01370 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DIR45_01375 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DIR45_01385 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DIR45_01485 ENOG4105K8N protein family UPF0079, ATPase DIR45_01490 ENOG41072GX Peptidase M22 Glycoprotease DIR45_01495 ENOG410801F ribosomal-protein-alanine acetyltransferase DIR45_01500 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DIR45_01505 ENOG4105C5H ABC transporter DIR45_01520 ENOG4108TYN CAAX amino terminal protease family protein DIR45_01540 ENOG4105C7N Xanthine uracil vitamin C permease DIR45_01550 ENOG4105BZU Histidine kinase DIR45_01575 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DIR45_01595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_01620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DIR45_01625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DIR45_01630 ENOG4105C83 adenylosuccinate lyase DIR45_01640 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DIR45_01665 ENOG4108V3E phosphoribosylglycinamide formyltransferase DIR45_01675 ENOG4105C12 Phosphoribosylglycinamide synthetase DIR45_01705 ENOG4105C4R Atp-dependent dna helicase DIR45_01735 ENOG4108W2Y isochorismatase DIR45_01745 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DIR45_01750 ENOG4108UMI ABC transporter, permease DIR45_01755 ENOG4105D01 (LipO)protein DIR45_01775 ENOG410834F Transcriptional regulator DIR45_01800 ENOG4105CBD Diacylglycerol kinase DIR45_01805 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DIR45_01810 ENOG4108JPW Aminotransferase DIR45_01820 ENOG4105C26 Dehydrogenase DIR45_01825 ENOG4105KPY Small multidrug resistance protein DIR45_01845 ENOG4105D9N nucleoside DIR45_01850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DIR45_01865 ENOG4108W15 Protein of unknown function (DUF1456) DIR45_01880 ENOG4105DTQ mandelate racemase muconate lactonizing DIR45_01890 ENOG4105DFD Na H antiporter DIR45_01910 ENOG4105D3R alkyl hydroperoxide reductase DIR45_01915 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DIR45_01925 ENOG4107W7X Aldolase DIR45_01930 ENOG4105EHG Permease protein DIR45_01935 ENOG4105DQ5 transport system permease protein DIR45_01940 ENOG4108V5C ABC transporter DIR45_01970 ENOG4106UIA DIR45_01975 ENOG4106UIA DIR45_02010 ENOG4105BZU Histidine kinase DIR45_02030 ENOG410756H nucleotidyltransferase DIR45_02035 ENOG4105D2S major facilitator superfamily DIR45_02050 ENOG4105E5Q amino acid AbC transporter DIR45_02055 ENOG4105EAB amino acid AbC transporter DIR45_02070 ENOG4105C8Q Methyl-accepting chemotaxis DIR45_02075 ENOG4105C8Q Methyl-accepting chemotaxis DIR45_02085 ENOG4105CI1 PTS System DIR45_02115 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DIR45_02130 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DIR45_02145 ENOG4105C5H ABC transporter DIR45_02170 ENOG41062JF Transcriptional regulator DIR45_02190 ENOG4105DEU major facilitator superfamily DIR45_02205 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) DIR45_02220 ENOG4108N0M stress protein DIR45_02225 ENOG4106FN3 tellurium resistance protein DIR45_02230 ENOG4106FN3 tellurium resistance protein DIR45_02235 ENOG4107TS3 membrane protein, TerC DIR45_02240 ENOG4108TTB tellurium resistance protein DIR45_02260 ENOG4105KJF protein tyrosine phosphatase DIR45_02270 ENOG4107U9T Pfam:Ribonuclease_BN DIR45_02280 ENOG4105C59 p-type ATPase DIR45_02285 ENOG4108IPJ Membrane DIR45_02305 ENOG4107ZTW SNARE associated Golgi DIR45_02320 ENOG410606W general stress protein DIR45_02325 ENOG4105UPD Calcium Proton DIR45_02365 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DIR45_02370 ENOG4105VTR Integrase DIR45_02375 ENOG4108IMY Transcriptional regulator DIR45_02685 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DIR45_02695 ENOG4108JUB Transcriptional regulator DIR45_02705 ENOG4108IQI permease DIR45_02740 ENOG4105CSV Glutaminase DIR45_02755 ENOG4108A04 Beta-lactamase DIR45_02770 ENOG4105CKK Glycosyl transferase, family 2 DIR45_02780 ENOG4107QQG Dehydrogenase DIR45_02785 ENOG4105C3I Nad-dependent epimerase dehydratase DIR45_02805 ENOG4105F1A Pyruvate formate-lyase DIR45_02825 ENOG4105CI2 imidazolone-5-propionate hydrolase DIR45_02830 ENOG4105ECP epimerase DIR45_02860 ENOG41067AE Membrane-bound metal-dependent hydrolase DIR45_02865 ENOG4105CEN a g-specific adenine glycosylase DIR45_02870 ENOG4106BXE DIR45_02890 ENOG4105BZ1 (ABC) transporter DIR45_02895 ENOG4107NBY Membrane DIR45_02900 ENOG4105CBC glutamate synthase DIR45_02910 ENOG4108IUW ABC transporter DIR45_02930 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DIR45_02935 ENOG4105G5W regulator Fur family DIR45_03055 ENOG4108JQC penicillin-binding protein 1A DIR45_03060 ENOG4107ZQN disulfide bond DIR45_03070 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DIR45_03080 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DIR45_03085 ENOG4105BZU Histidine kinase DIR45_03095 ENOG4105CYN Serine protein kinase DIR45_03125 ENOG4105C94 Transporter DIR45_03140 ENOG4105DZ6 Band 7 protein DIR45_03150 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DIR45_03155 ENOG4108MRH transcriptional regulatory protein DIR45_03160 ENOG4105D4T Citrate transporter DIR45_03185 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DIR45_03190 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DIR45_03195 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DIR45_03200 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DIR45_03205 ENOG4105BZ7 extracellular solute-binding protein family 1 DIR45_03210 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DIR45_03215 ENOG4108STX response regulator DIR45_03220 ENOG4105US7 Histidine kinase DIR45_03245 ENOG4108MRH transcriptional regulatory protein DIR45_03255 ENOG4105C6K Malic enzyme DIR45_03265 ENOG4108UZ3 Transporter DIR45_03270 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DIR45_03280 ENOG4105BZU Histidine kinase DIR45_03285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_03295 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DIR45_03300 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DIR45_03305 ENOG4108JB9 formate dehydrogenase DIR45_03325 ENOG4105CUB amino acid DIR45_03340 ENOG4105C59 p-type ATPase DIR45_03345 ENOG4105DAP Nicotinate phosphoribosyltransferase DIR45_03380 ENOG41073R8 VanW family DIR45_03385 ENOG4108KGH TRANSCRIPTIONal DIR45_03390 ENOG4105D9N nucleoside DIR45_03395 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DIR45_03400 ENOG4105C37 (CBS) domain DIR45_03405 ENOG4108IJ0 Aspartate ammonia-lyase DIR45_03410 ENOG4105DAA L-lactate DIR45_03425 ENOG4105DUX Transporter DIR45_03430 ENOG4108MES Periplasmic binding protein DIR45_03435 ENOG4105DQ5 transport system permease protein DIR45_03440 ENOG4108IHU transport system permease protein DIR45_03445 ENOG4105E0A ABC, transporter DIR45_03450 ENOG4105DMQ Methyltransferase DIR45_03460 ENOG4105EXW epimerase dehydratase DIR45_03470 ENOG4107T89 von Willebrand factor, type A DIR45_03475 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DIR45_03480 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DIR45_03495 ENOG4105BZU Histidine kinase DIR45_03500 ENOG4105D5Q Arginine ornithine antiporter DIR45_03505 ENOG4107414 GntR family transcriptional regulator DIR45_03510 ENOG4105C5Y PTS System DIR45_03515 ENOG4105CG3 alpha amylase, catalytic region DIR45_03530 ENOG4105E1K spore germination protein DIR45_03540 ENOG4105CRN Aminoglycoside phosphotransferase DIR45_03545 ENOG4105BZG amino acid carrier protein DIR45_03550 ENOG4105CDA abc transporter atp-binding protein DIR45_03555 ENOG4105CT1 (ABC) transporter DIR45_03560 ENOG4105EAD ABC transporter DIR45_03565 ENOG4105DRP amino acid AbC transporter DIR45_03570 ENOG4108IQI permease DIR45_03595 ENOG4105D29 Helix-turn-helix type 11 domain protein DIR45_03600 ENOG4105NAE bifunctional deaminase-reductase domain protein DIR45_03605 ENOG4105BZU Histidine kinase DIR45_03620 ENOG4105CHH sulfate transporter DIR45_03625 ENOG41068KF Universal stress protein DIR45_03635 ENOG4105DEF Extracellular solute-binding protein, family 5 DIR45_03645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DIR45_03650 ENOG4108JQ7 (ABC) transporter DIR45_03660 ENOG4105CXY transporter DIR45_03665 ENOG41067TZ transcriptional regulator, MarR family DIR45_03675 ENOG4105ETE Transcriptional regulator (LacI family DIR45_03680 ENOG4108RVA ribokinase DIR45_03690 ENOG4105C2J ABC transporter DIR45_03695 ENOG4105CNN ABC, transporter DIR45_03700 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DIR45_03705 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DIR45_03765 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DIR45_03770 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DIR45_03775 ENOG41069ER domain protein DIR45_03780 ENOG4105VZ8 Transcriptional regulator DIR45_03785 ENOG4107D63 DIR45_03795 ENOG4105DUX Transporter DIR45_03815 ENOG4105C85 amino acid DIR45_03820 ENOG4105C7N Xanthine uracil vitamin C permease DIR45_03860 ENOG4105BZ9 Cytochrome C oxidase, subunit I DIR45_03865 ENOG4105E2S oxidase) subunit II DIR45_03870 ENOG4108IQI permease DIR45_03885 ENOG4106CAD Protein of unknown function (DUF3311) DIR45_03890 ENOG4105E1V na solute symporter DIR45_03915 ENOG4105CE1 Ferrous iron transport protein b DIR45_03920 ENOG4105CE1 Ferrous iron transport protein b DIR45_03925 ENOG4105CE1 Ferrous iron transport protein b DIR45_03930 ENOG4105CVA phosphate DIR45_03935 ENOG4105C8U phosphate abc transporter DIR45_03940 ENOG4105E2Z phosphate ABC transporter (Permease DIR45_04070 ENOG41080XQ Signal transduction protein with cbs domains DIR45_04095 ENOG4105ETU transcriptional activator (TenA DIR45_04105 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DIR45_04115 ENOG4108VEU Thiamine monophosphate synthase DIR45_04120 ENOG41080HI glycine oxidase DIR45_04135 ENOG4105D06 uba thif-type nad fad binding protein DIR45_04140 ENOG4105DWF phosphomethylpyrimidine kinase DIR45_04195 ENOG4108INS Transcriptional regulator DIR45_04210 ENOG4105C7N Xanthine uracil vitamin C permease DIR45_04220 ENOG4108PXI ErfK YbiS YcfS YnhG DIR45_04240 ENOG4105C5Y PTS System DIR45_04295 ENOG4107Y03 Nitroreductase DIR45_04300 ENOG4105ED1 spovr family DIR45_04330 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DIR45_04335 ENOG4105XTG Pfam:DUF156 DIR45_04340 ENOG4105VFE sira family DIR45_04345 ENOG4107TPS domain protein DIR45_04350 ENOG4105VFE sira family DIR45_04355 ENOG41085GJ domain protein DIR45_04365 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DIR45_04370 ENOG41087NI Sulfite exporter TauE/SafE DIR45_04380 ENOG4108KGH TRANSCRIPTIONal DIR45_04405 ENOG4105EMD TRANSCRIPTIONal DIR45_04410 ENOG4105VCP PTS System DIR45_04415 ENOG4105VZJ PTS System DIR45_04435 ENOG41069ER domain protein DIR45_04440 ENOG4107RBB ABC transporter, permease DIR45_04445 ENOG4105C19 ABC transporter DIR45_04475 ENOG4105WEF catalase DIR45_04510 ENOG4107T5V SNARE associated Golgi DIR45_04545 ENOG4105CUB amino acid DIR45_04550 ENOG4107RWR Sodium hydrogen exchanger DIR45_04560 ENOG4106KNT transcriptional regulator DIR45_04595 ENOG4108PCN EamA-like transporter family DIR45_04600 ENOG4108YXU transcriptional regulator AsnC family DIR45_04610 ENOG4105KPY Small multidrug resistance protein DIR45_04615 ENOG4105KPY Small multidrug resistance protein DIR45_04640 ENOG4105NF4 modulator of drug activity DIR45_04645 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DIR45_04650 ENOG4105E5W Transporter DIR45_04660 ENOG4107RKG DJ-1/PfpI family DIR45_04665 ENOG4105CH6 catalase DIR45_04675 ENOG4105D5Q Arginine ornithine antiporter DIR45_04680 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DIR45_04690 ENOG4105C26 Dehydrogenase DIR45_04710 ENOG4105BZ1 (ABC) transporter DIR45_04730 ENOG4105DRP amino acid AbC transporter DIR45_04735 ENOG4105CDA abc transporter atp-binding protein DIR45_04750 ENOG410839P DIR45_04785 ENOG4107FQX Alpha-acetolactate decarboxylase DIR45_04810 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DIR45_04820 ENOG4105D4P Coproporphyrinogen iii oxidase DIR45_04835 ENOG4105CHH sulfate transporter DIR45_04875 ENOG4106AKK s-layer domain-containing protein DIR45_04885 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DIR45_04890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DIR45_04910 ENOG4105CGU Enoyl-CoA hydratase DIR45_04930 ENOG4105DER m42 family DIR45_04950 ENOG4105CTU Proline racemase DIR45_04990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DIR45_05000 ENOG4108JQ7 (ABC) transporter DIR45_05010 ENOG4105PKS Excinuclease abc c subunit domain protein DIR45_05045 ENOG4105CSH Transporter DIR45_05055 ENOG4108MRH transcriptional regulatory protein DIR45_05105 ENOG4105CDU Replicative dna helicase DIR45_05155 ENOG4105C0R drug resistance transporter emrb qaca subfamily DIR45_05210 ENOG4108IG5 Transcriptional regulator DIR45_05230 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DIR45_05255 ENOG4105CMT Dihydroxyacetone kinase DIR45_05270 ENOG4105CMT Dihydroxyacetone kinase DIR45_05275 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DIR45_05280 ENOG410847I Transcriptional regulator, BadM Rrf2 family DIR45_05315 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DIR45_05395 ENOG4105WN5 stage II sporulation protein DIR45_05405 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_05415 ENOG4108MJI response regulator DIR45_05420 ENOG4105BZU Histidine kinase DIR45_05425 ENOG4105BZU Histidine kinase DIR45_05450 ENOG4105K8R UPF0145 protein DIR45_05485 ENOG4107VRP DNA repair exonuclease DIR45_05490 ENOG4106D4I domain protein DIR45_05495 ENOG4105D7V transposase DIR45_05510 ENOG4108IND Tetr family transcriptional regulator DIR45_05515 ENOG4105EQ0 Major Facilitator superfamily DIR45_05540 ENOG4108MUZ hydrolase DIR45_05560 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DIR45_05575 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DIR45_05595 ENOG4105EMN RNA polymerase sigma factor DIR45_05620 ENOG4105C57 major facilitator superfamily DIR45_05625 ENOG4105C0R drug resistance transporter emrb qaca subfamily DIR45_05635 ENOG4105EEM helicase DIR45_05640 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DIR45_05670 ENOG4105K59 histidine triad (HIT) protein DIR45_05710 ENOG410905X membrane-flanked domain protein DIR45_05760 ENOG410905X membrane-flanked domain protein DIR45_05765 ENOG4105CKV Membrane DIR45_05770 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DIR45_05775 ENOG4105BZ4 penicillin-binding protein DIR45_05780 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DIR45_05790 ENOG4105C1Q protoporphyrinogen oxidase DIR45_05815 ENOG4105NA0 Transcriptional regulator DIR45_05830 ENOG4105ECB domain protein DIR45_05860 ENOG4106AXD DIR45_05865 ENOG4108RQ5 Beta-lactamase domain-containing protein DIR45_05870 ENOG4105DF9 Lipoate-protein, ligase DIR45_05880 ENOG4105CEY Amp-dependent synthetase and ligase DIR45_05910 ENOG4105CNA YD repeat protein DIR45_05945 ENOG4105ENX hydrolase DIR45_05955 ENOG4107RN3 metallophosphoesterase DIR45_05960 ENOG4107TVP HD domain protein DIR45_05970 ENOG4108AEY RNA polymerase sigma factor DIR45_05975 ENOG41086D8 Transcriptional regulator DIR45_05995 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_06020 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DIR45_06025 ENOG4105C8Q Methyl-accepting chemotaxis DIR45_06045 ENOG4105ZU5 s-layer protein DIR45_06050 ENOG4107QP3 malate synthase g DIR45_06065 ENOG4105VEQ Cold shock protein DIR45_06080 ENOG4105XVF Competence transcription factor DIR45_06095 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DIR45_06100 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DIR45_06145 ENOG4105ERH Fumarylacetoacetate hydrolase DIR45_06170 ENOG4105CAQ asparagine synthetase DIR45_06175 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DIR45_06180 ENOG4105CH6 catalase DIR45_06185 ENOG4105BZU Histidine kinase DIR45_06210 ENOG4105QNR S1 RNA binding domain protein DIR45_06220 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DIR45_06230 ENOG4107AYK membrAne DIR45_06235 ENOG41073B9 DIR45_06245 ENOG4108KP7 hydrolase DIR45_06260 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DIR45_06290 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DIR45_06295 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DIR45_06315 ENOG4105C31 Tryptophanyl-tRNA synthetase DIR45_06335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DIR45_06340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DIR45_06350 ENOG4108JQ7 (ABC) transporter DIR45_06355 ENOG4105UQX Mate efflux family protein DIR45_06380 ENOG4108ZCF integral membrane protein DIR45_06390 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DIR45_06400 ENOG4105DPN Oligoendopeptidase f DIR45_06415 ENOG4108Z18 K06886 hemoglobin DIR45_06420 ENOG4105MIX Adenylate cyclase DIR45_06435 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DIR45_06440 ENOG4105EMS pseudouridine synthase DIR45_06460 ENOG4105K64 Glycosyl transferase, family 2 DIR45_06500 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DIR45_06505 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DIR45_06515 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DIR45_06565 ENOG4108WVJ 2'-5' rna ligase DIR45_06590 ENOG4105CK7 Sodium proline symporter DIR45_06600 ENOG4105CRQ synthase (Component I) DIR45_06605 ENOG4105DDQ anthranilate synthase DIR45_06705 ENOG4105C7S Dehydrogenase DIR45_06715 ENOG4105VZ8 Transcriptional regulator DIR45_06775 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DIR45_06790 ENOG4105DZ1 carboxypeptidase DIR45_06795 ENOG4105VFR signal peptidase DIR45_06830 ENOG4105C26 Dehydrogenase DIR45_06835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DIR45_06840 ENOG4105F38 ABC transporter, permease DIR45_06845 ENOG4105D38 putrescine abc transporter DIR45_06850 ENOG4107RUE extracellular solute-binding protein family 1 DIR45_06860 ENOG4105EYF MMPL domain protein DIR45_06870 ENOG4108YBP pseudouridine synthase DIR45_06880 ENOG4105K4I Scp-like extracellular DIR45_06885 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DIR45_06890 ENOG4105CQB FAD linked oxidase domain protein DIR45_06905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_06910 ENOG4105BZU Histidine kinase DIR45_06915 ENOG4105JXH GntR family transcriptional regulator DIR45_06935 ENOG4106A3R peptidase DIR45_06945 ENOG4108QTI )-transporter DIR45_06950 ENOG4107TS3 membrane protein, TerC DIR45_06960 ENOG410681C small acid-soluble spore protein DIR45_06965 ENOG4108Z7G MaoC domain protein dehydratase DIR45_06985 ENOG4105CHR reductase DIR45_06995 ENOG4105MWK D-amino acid dehydrogenase, small subunit DIR45_07020 ENOG4105C4Y ABC transporter DIR45_07035 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DIR45_07050 ENOG4105E98 transcriptional regulator DeoR family DIR45_07070 ENOG4105PXI polysaccharide deacetylase DIR45_07080 ENOG4105BZU Histidine kinase DIR45_07085 ENOG41090MY MarR family Transcriptional regulator DIR45_07095 ENOG4106DF1 DIR45_07105 ENOG4105BZU Histidine kinase DIR45_07115 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DIR45_07120 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DIR45_07165 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DIR45_07185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DIR45_07190 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DIR45_07195 ENOG4105CZV ABC transporter DIR45_07205 ENOG4105CJ1 ABC, transporter DIR45_07245 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DIR45_07250 ENOG4105EA8 2-Nitropropane dioxygenase DIR45_07255 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DIR45_07265 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DIR45_07290 ENOG4105NQC Flavodoxin DIR45_07330 ENOG4107QMU Mate efflux family protein DIR45_07335 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DIR45_07365 ENOG4105CZN Potassium uptake protein DIR45_07370 ENOG41063Y9 DIR45_07375 ENOG4105KBJ sporulation protein ytfj DIR45_07405 ENOG4105CM2 brancheD-chain amino acid aminotransferase DIR45_07410 ENOG4105C7K acetolactate synthase DIR45_07415 ENOG4108ZP8 Acetolactate synthase small subunit DIR45_07420 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DIR45_07430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DIR45_07455 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DIR45_07490 ENOG4107RVV histidinol phosphate phosphatase, hisj family DIR45_07505 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DIR45_07510 ENOG4105E0M Sulfatase DIR45_07520 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DIR45_07540 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DIR45_07545 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DIR45_07555 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DIR45_07560 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DIR45_07565 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DIR45_07575 ENOG4105C8J )-transporter DIR45_07595 ENOG4105DFD Na H antiporter DIR45_07615 ENOG4105ENE Histidine kinase DIR45_07620 ENOG4105WH1 Two component transcriptional regulator luxr family DIR45_07640 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DIR45_07665 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DIR45_07690 ENOG4105CJ3 phosphate transporter DIR45_07695 ENOG4107GRR phosphate transport regulator DIR45_07700 ENOG4105BZ4 penicillin-binding protein DIR45_07720 ENOG4105I3N Conserved Protein DIR45_07735 ENOG4105BZU Histidine kinase DIR45_07780 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DIR45_07785 ENOG4105DZ1 carboxypeptidase DIR45_07790 ENOG4108JIC nucleoside recognition domain protein DIR45_07800 ENOG4105FE9 pseudouridine synthase DIR45_07810 ENOG4107TWT Cytochrome c biogenesis protein DIR45_07815 ENOG4105CRE cytochrome C DIR45_07820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_07825 ENOG4105BZU Histidine kinase DIR45_07830 ENOG4108WBT adenosyltransferase DIR45_07845 ENOG4108SAX Membrane DIR45_07855 ENOG4105T7X DIR45_07860 ENOG4105C9U ATP-dependent DNA helicase RecQ DIR45_07865 ENOG4105I7S Abortive infection protein DIR45_07880 ENOG4107X2D transcriptional regulator, merr family DIR45_07885 ENOG4108S6Z Negative regulator of genetic competence DIR45_07910 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DIR45_07915 ENOG4105HDK L-asparaginase DIR45_07950 ENOG4105S2F DIR45_07955 ENOG41065D1 DIR45_07985 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DIR45_08000 ENOG4105XXQ heptaprenyl diphosphate synthase component I DIR45_08010 ENOG4105EAH synthase DIR45_08030 ENOG4105CIH Imidazole acetol-phosphate transaminase DIR45_08035 ENOG41068YB TPR repeat-containing protein DIR45_08050 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DIR45_08055 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DIR45_08060 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DIR45_08095 ENOG4108JYZ YitT family DIR45_08105 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DIR45_08120 ENOG4105FJR Lmbe family DIR45_08125 ENOG4105CPK Glycosyl transferase (Group 1 DIR45_08170 ENOG4105YAC DIR45_08190 ENOG4105CSM endonuclease III DIR45_08200 ENOG4105BZ4 penicillin-binding protein DIR45_08260 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DIR45_08270 ENOG4105DVT helicase DIR45_08275 ENOG4105CTD carboxy-peptidase DIR45_08290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DIR45_08300 ENOG4105C2W permease DIR45_08305 ENOG4105DHF Membrane DIR45_08315 ENOG410890F Dynamin family DIR45_08325 ENOG4108W0I acetyltransferase DIR45_08335 ENOG4105KHC sulfurtransferase DIR45_08360 ENOG4106032 Glutathionylspermidine synthase DIR45_08440 ENOG4108SZE gCN5-related N-acetyltransferase DIR45_08460 ENOG41081VK Ribonuclease DIR45_08525 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DIR45_08540 ENOG4107RWR Sodium hydrogen exchanger DIR45_08545 ENOG4105CN5 Metallo-Beta-Lactamase DIR45_08550 ENOG4108Z5V transcriptional regulator, merr family DIR45_08560 ENOG4105H67 Protein of unknown function (DUF421) DIR45_08565 ENOG41080C8 DUF218 domain DIR45_08620 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DIR45_08630 ENOG4107R0U MotA TolQ exbB proton channel DIR45_08635 ENOG4105ER2 Ompa motb domain protein DIR45_08640 ENOG4107YTP response regulator receiver protein DIR45_08650 ENOG4105DD5 Flagellar motor switch protein DIR45_08665 ENOG4105BZU Histidine kinase DIR45_08685 ENOG4105E1Q flagellar hook-associated protein DIR45_08710 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DIR45_08715 ENOG4108ZC9 flagellar basal-body rod protein flgc DIR45_08720 ENOG41075Z6 flagellar hook-basal body complex protein fliE DIR45_08730 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DIR45_08765 ENOG4105BZE flagellar hook protein, FlgE DIR45_08785 ENOG4107R88 Chemotaxis protein (CheV) DIR45_08795 ENOG4105K64 Glycosyl transferase, family 2 DIR45_08835 ENOG4107TVC Glycosyl transferase, family 2 DIR45_08850 ENOG4105I03 Flagellin DIR45_08855 ENOG4105E4C Lytic transglycosylase catalytic DIR45_08870 ENOG4105DD5 Flagellar motor switch protein DIR45_08880 ENOG4105CN7 Flagellar biosynthetic protein FliP DIR45_08885 ENOG4105VS8 Flagellar biosynthetic protein fliq DIR45_08895 ENOG4105D00 flagellar biosynthetic protein flhB DIR45_08900 ENOG4105D7B Flagellar biosynthesis protein flha DIR45_08905 ENOG4105FZW flagellar biosynthesis regulator FlhF DIR45_08910 ENOG4105KTQ flagellar basal-body rod protein DIR45_08915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DIR45_08940 ENOG4108RZE Tetr family transcriptional regulator DIR45_08960 ENOG4105KAC Antibiotic biosynthesis monooxygenase DIR45_08990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DIR45_08995 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DIR45_09000 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DIR45_09005 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DIR45_09045 ENOG4105CVJ phosphoglycerate mutase DIR45_09075 ENOG4105CAQ asparagine synthetase DIR45_09095 ENOG4105PGM cation diffusion facilitator family transporter DIR45_09105 ENOG4105DRR Transcriptional regulator, GntR family DIR45_09110 ENOG4108UZ3 Transporter DIR45_09115 ENOG4105CKI cobalamin synthesis protein DIR45_09125 ENOG4108PJD permease DIR45_09140 ENOG4105DFD Na H antiporter DIR45_09145 ENOG4105C9Q fumarate hydratase class II DIR45_09175 ENOG4105EC3 peptidase S51, dipeptidase E DIR45_09195 ENOG4107QIV Cytochrome c biogenesis protein DIR45_09230 ENOG4106BRA Membrane DIR45_09270 ENOG4105CJ1 ABC, transporter DIR45_09290 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DIR45_09300 ENOG4108IJ0 Aspartate ammonia-lyase DIR45_09305 ENOG4105C6K Malic enzyme DIR45_09380 ENOG4105FVX DIR45_09420 ENOG4105CSR polyphosphate kinase 2 DIR45_09430 ENOG4105DXI Major Facilitator superfamily DIR45_09445 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DIR45_09460 ENOG4105C6T cysteine synthase DIR45_09480 ENOG4105C8J )-transporter DIR45_09490 ENOG4105X5K response regulator receiver protein DIR45_09495 ENOG4105H67 Protein of unknown function (DUF421) DIR45_09515 ENOG4106KE4 Dehydrogenase DIR45_09535 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DIR45_09540 ENOG4105CHR reductase DIR45_09545 ENOG4105CM2 brancheD-chain amino acid aminotransferase DIR45_09550 ENOG4105C7K acetolactate synthase DIR45_09555 ENOG4108ZP8 Acetolactate synthase small subunit DIR45_09560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DIR45_09570 ENOG4105C7B Threonine dehydratase DIR45_09600 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DIR45_09610 ENOG4105DY9 regulatoR DIR45_09615 ENOG4105CYC Transferase DIR45_09635 ENOG4105F6J Alpha beta hydrolase fold DIR45_09645 ENOG4108J59 Extracellular solute-binding protein, family 5 DIR45_09685 ENOG41068WN DIR45_09705 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DIR45_09710 ENOG4105C72 UPF0176 protein DIR45_09720 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DIR45_09755 ENOG4107RHR regulatoR DIR45_09765 ENOG4105D9N nucleoside DIR45_09770 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DIR45_09805 ENOG4107RAQ aminopeptidase DIR45_09810 ENOG4107STQ Multicopper oxidase DIR45_09855 ENOG4108T5E Copper resistance protein DIR45_09860 ENOG4105KTB nuclear export factor GLE1 DIR45_09870 ENOG4107RT3 EamA-like transporter family DIR45_09875 ENOG4105GZI Transcriptional regulator DIR45_09880 ENOG4108Z40 Transcriptional regulator DIR45_09885 ENOG4107ZXU DSBA oxidoreductase DIR45_09890 ENOG4108TVJ Nitroreductase DIR45_09900 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DIR45_09905 ENOG4106F5Q Membrane DIR45_09910 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DIR45_09920 ENOG4105CKI cobalamin synthesis protein DIR45_09940 ENOG4108Z7G MaoC domain protein dehydratase DIR45_09945 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DIR45_09960 ENOG4105C0Z ABC transporter DIR45_09965 ENOG4108IV0 ABC, transporter DIR45_09970 ENOG4105C32 Amino acid ABC transporter (Permease) DIR45_09980 ENOG4105SKE transcriptional Regulator LysR family DIR45_09990 ENOG4105MDS 4-oxalocrotonate tautomerase DIR45_10000 ENOG4105YGB Transcriptional regulator DIR45_10010 ENOG4105C4M (Ubiquinol oxidase) subunit I DIR45_10015 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DIR45_10020 ENOG4108JJ9 ABC, transporter DIR45_10025 ENOG4108JJ8 (ABC) transporter DIR45_10075 ENOG4105EFI regulatoR DIR45_10100 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DIR45_10105 ENOG4108ZJ4 polysaccharide deacetylase DIR45_10130 ENOG4105D6E homoserine dehydrogenase DIR45_10155 ENOG4108KGH TRANSCRIPTIONal DIR45_10165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_10170 ENOG4105BZU Histidine kinase DIR45_10175 ENOG4107VMI polysaccharide deacetylase DIR45_10185 ENOG4105KT7 mgtC SapB transporter DIR45_10190 ENOG4105VRR gCN5-related N-acetyltransferase DIR45_10200 ENOG4105DUU IucA IucC family protein DIR45_10205 ENOG4105CEY Amp-dependent synthetase and ligase DIR45_10220 ENOG4108WBH protein TIM barrel DIR45_10225 ENOG4105YWU small acid-soluble spore protein DIR45_10235 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DIR45_10290 ENOG4105KRN Transcriptional regulator, abrb family DIR45_10300 ENOG4105YVS arsR family transcriptional regulator DIR45_10305 ENOG4107SET aldo keto reductase DIR45_10340 ENOG4105C8Q Methyl-accepting chemotaxis DIR45_10360 ENOG4108K88 Membrane DIR45_10365 ENOG4108WPJ Ferritin-like domain DIR45_10380 ENOG4105DEN Luciferase family DIR45_10400 ENOG4107QM2 Aldo Keto reductase DIR45_10405 ENOG4105CKI cobalamin synthesis protein DIR45_10490 ENOG4105DSE periplasmic solute binding protein DIR45_10500 ENOG4105K4T epimerase DIR45_10510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DIR45_10535 ENOG4105CVJ phosphoglycerate mutase DIR45_10555 ENOG4107T5V SNARE associated Golgi DIR45_10570 ENOG4108PJD permease DIR45_10580 ENOG4108S4H thioesterase Superfamily protein DIR45_10590 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DIR45_10610 ENOG4105SXS Protein of unknown function (DUF456) DIR45_10615 ENOG4105C37 (CBS) domain DIR45_10635 ENOG4108Z7R Chaperone CsaA DIR45_10655 ENOG4108ZRV stage ii sporulation protein p DIR45_10665 ENOG4108VXD carboxy-peptidase DIR45_10675 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DIR45_10700 ENOG4108X4Q Hydrolase DIR45_10710 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DIR45_10715 ENOG4107RBS Methyltransferase DIR45_10730 ENOG41087PP glycosyltransferase MGT family DIR45_10735 ENOG4108JYZ YitT family DIR45_10740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DIR45_10770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DIR45_10830 ENOG4105KBJ sporulation protein ytfj DIR45_10855 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DIR45_10875 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DIR45_10880 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_10890 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DIR45_10895 ENOG4105EMN RNA polymerase sigma factor DIR45_10920 ENOG4108V06 Glutathione peroxidase DIR45_10935 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DIR45_10955 ENOG4108IUE nitrate reductase beta subunit DIR45_10960 ENOG4105R3A Nitrate reductase DIR45_10985 ENOG4107V6Q Cyclic nucleotide-binding domain DIR45_10990 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DIR45_10995 ENOG4105D06 uba thif-type nad fad binding protein DIR45_11000 ENOG4105CVM Molybdenum cofactor synthesis domain protein DIR45_11005 ENOG4108ZAF Molybdopterin DIR45_11035 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DIR45_11040 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DIR45_11045 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DIR45_11050 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DIR45_11055 ENOG4108IFG nitrite reductase, (NAD(P)H) DIR45_11060 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DIR45_11095 ENOG4105MCT stage V sporulation protein S DIR45_11115 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DIR45_11135 ENOG4105C5H ABC transporter DIR45_11150 ENOG4108UUM single-stranded DNA-binding protein DIR45_11180 ENOG4107YX5 Pfam:DUF548 DIR45_11185 ENOG4105C75 arginyL-tRNA synthetase DIR45_11215 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DIR45_11235 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DIR45_11240 ENOG4105C5S asparaginyl-tRNA synthetase DIR45_11355 ENOG4105BZW Glycerate kinase DIR45_11360 ENOG4107QPK )-transporter DIR45_11365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_11370 ENOG41062D9 Histidine kinase DIR45_11385 ENOG4105C8J )-transporter DIR45_11405 ENOG4107XGZ Hydrolase DIR45_11410 ENOG4105CY2 Citrate transporter DIR45_11415 ENOG4105C0A alcohol dehydrogenase DIR45_11430 ENOG4105KD7 acetyltransferase DIR45_11460 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DIR45_11480 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DIR45_11495 ENOG4107RVG penicillin-binding protein DIR45_11500 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DIR45_11505 ENOG4105E9Q Acyl-transferase DIR45_11510 ENOG4108UT2 hemolysin iii DIR45_11520 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DIR45_11535 ENOG4108RCR degv family DIR45_11540 ENOG4105E8R UPF0173 metal-dependent hydrolase DIR45_11545 ENOG4108KF3 Electron transport protein SCO1 SenC DIR45_11550 ENOG4107Y70 Heat shock protein DIR45_11555 ENOG4105CAQ asparagine synthetase DIR45_11575 ENOG4108MES Periplasmic binding protein DIR45_11580 ENOG4105F0I Aminotransferase DIR45_11615 ENOG4105D8X mechanosensitive ion channel DIR45_11620 ENOG4105BZU Histidine kinase DIR45_11625 ENOG4105WH1 Two component transcriptional regulator luxr family DIR45_11665 ENOG4105CMG Carbohydrate kinase DIR45_11670 ENOG4105CMG Carbohydrate kinase DIR45_11700 ENOG4108IJ8 ABC transporter DIR45_11705 ENOG4105E90 ABC transporter DIR45_11740 ENOG4105C37 (CBS) domain DIR45_11770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DIR45_11785 ENOG4107S4Y M20 DapE family protein YgeY DIR45_11790 ENOG4108TSC N-acetyltransferase DIR45_11795 ENOG4108JUB Transcriptional regulator DIR45_11805 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DIR45_11845 ENOG4108N23 SpoOM-related protein DIR45_11850 ENOG410841Q phosphoesterase PA-phosphatase related protein DIR45_11860 ENOG4105SZ6 Thioredoxin DIR45_11875 ENOG4108IBT Inherit from COG: transposase DIR45_12010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DIR45_12050 ENOG4105BZ4 penicillin-binding protein DIR45_12055 ENOG4105CZM Major Facilitator DIR45_12060 ENOG4105W8X HesB YadR YfhF-family protein DIR45_12070 ENOG4105DXD 2-methylcitrate dehydratase DIR45_12075 ENOG4105CR4 methylisocitrate lyase DIR45_12080 ENOG4105C1G acyl-Coa dehydrogenase DIR45_12085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DIR45_12095 ENOG4105N14 lysine exporter protein LysE YggA DIR45_12100 ENOG4105E39 Enoyl-CoA hydratase DIR45_12115 ENOG4107RFY SbcCD D subunit DIR45_12120 ENOG4105EYH Exonuclease DIR45_12155 ENOG4105FCD Major Facilitator DIR45_12165 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DIR45_12170 ENOG4105E4F Isochorismate synthase DIR45_12175 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DIR45_12180 ENOG4105WQI isochorismatase DIR45_12190 ENOG4105WQT MbtH domain protein DIR45_12195 ENOG4105C0R drug resistance transporter emrb qaca subfamily DIR45_12210 ENOG4105K70 DNA-binding protein DIR45_12250 ENOG4105FE9 pseudouridine synthase DIR45_12255 ENOG4105C22 threonyL-tRNA synthetase DIR45_12275 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DIR45_12300 ENOG4108D32 Methyltransferase DIR45_12330 ENOG41081I9 integral membrane protein DIR45_12345 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DIR45_12355 ENOG4105EYF MMPL domain protein DIR45_12380 ENOG4105WCN acetyltransferase DIR45_12410 ENOG4105C1Q protoporphyrinogen oxidase DIR45_12420 ENOG41068WN DIR45_12430 ENOG4105VEQ Cold shock protein DIR45_12450 ENOG410667J hydrolase DIR45_12500 ENOG4107V2S Transcriptional regulator DIR45_12505 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DIR45_12520 ENOG4105DND Transcriptional regulator DIR45_12525 ENOG4108RPX mosc domain containing protein DIR45_12540 ENOG4105BZ1 (ABC) transporter DIR45_12545 ENOG4105BZ1 (ABC) transporter DIR45_12565 ENOG4108JCI Transcriptional regulator DIR45_12595 ENOG4108KPJ rna polymerase sigma factor DIR45_12625 ENOG4105F32 YngK protein DIR45_12655 ENOG4105RD7 BadF BadG BcrA BcrD DIR45_12665 ENOG4107STF Involved in phosphonate degradation (By similarity) DIR45_12695 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DIR45_12710 ENOG4105C1J atp-dependent rna helicase DIR45_12725 ENOG4108RZE Tetr family transcriptional regulator DIR45_12745 ENOG41088CC tellurite resistance protein tehB DIR45_12755 ENOG4108I0C methyltransferase DIR45_12760 ENOG4107RA9 decarboxylase DIR45_12765 ENOG41090HR transcriptional regulator DIR45_12815 ENOG4105CIN aminoacyl-histidine dipeptidase DIR45_12845 ENOG4107RF6 penicillin-binding protein DIR45_12850 ENOG4107RF6 penicillin-binding protein DIR45_12865 ENOG4105ETE Transcriptional regulator (LacI family DIR45_12875 ENOG4105CK5 oxidoreductase DIR45_12900 ENOG4105D2N Aldolase DIR45_12920 ENOG4105CGH 5'-nucleotidase DIR45_12935 ENOG4105VZ8 Transcriptional regulator DIR45_12950 ENOG4108VXD carboxy-peptidase DIR45_12970 ENOG41067SE Tetr family transcriptional regulator DIR45_12975 ENOG4105C5H ABC transporter DIR45_12985 ENOG4105BZU Histidine kinase DIR45_13000 ENOG4106ANW SMI1_KNR4 DIR45_13010 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DIR45_13025 ENOG4105CJ1 ABC, transporter DIR45_13035 ENOG4107Z3H Transcriptional regulator, TetR family DIR45_13055 ENOG4105C1G acyl-Coa dehydrogenase DIR45_13060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DIR45_13065 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DIR45_13070 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DIR45_13075 ENOG4105E39 Enoyl-CoA hydratase DIR45_13080 ENOG4107QX3 carboxylase DIR45_13085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DIR45_13095 ENOG4105WCN acetyltransferase DIR45_13100 ENOG4105DBI uridine monophosphokinase DIR45_13115 ENOG4105DZ1 carboxypeptidase DIR45_13130 ENOG4105T9C HD domain DIR45_13140 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DIR45_13180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DIR45_13180 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DIR45_13195 ENOG4105FQP Beta-lactamase DIR45_13205 ENOG4107Y80 Major Facilitator superfamily DIR45_13225 ENOG4105CUV Homoserine Kinase DIR45_13260 ENOG4105CPQ Dehydrogenase DIR45_13375 ENOG4105ETU transcriptional activator (TenA DIR45_13505 ENOG410667J hydrolase DIR45_13515 ENOG4105BZU Histidine kinase DIR45_13520 ENOG4107RF6 penicillin-binding protein DIR45_13540 ENOG4108JJB ABC transporter DIR45_13555 ENOG4108HGU Histidine kinase DIR45_13570 ENOG4105CB2 alcohol dehydrogenase DIR45_13575 ENOG4105CJN penicillin-binding protein DIR45_13585 ENOG4105FQP Beta-lactamase DIR45_13620 ENOG4108V4B ThiJ pfpI DIR45_13655 ENOG4107Y80 Major Facilitator superfamily DIR45_13675 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DIR45_13735 ENOG4105FCD Major Facilitator DIR45_13750 ENOG4105E09 nadh pyrophosphatase DIR45_13755 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DIR45_13760 ENOG4108Z4K mutator MutT protein DIR45_13795 ENOG4108XI2 Domain of unknown function (DUF1963) DIR45_13830 ENOG4105KWG Pfam:DUF1696 DIR45_13865 ENOG4105PKS Excinuclease abc c subunit domain protein DIR45_13910 ENOG4107VFR oxidoreductase DIR45_13935 ENOG4105PAD Hydrolase DIR45_13955 ENOG4105DY8 decarboxylase DIR45_13970 ENOG4108IUM Glycogen debranching enzyme DIR45_13995 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DIR45_14005 ENOG4105FDR Membrane DIR45_14040 ENOG4108V3A UPF0421 protein DIR45_14060 ENOG4105MSI germination protein ypeb DIR45_14080 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DIR45_14085 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DIR45_14090 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DIR45_14095 ENOG4107Z3H Transcriptional regulator, TetR family DIR45_14130 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DIR45_14150 ENOG4105E98 transcriptional regulator DeoR family DIR45_14170 ENOG41062ES Transcriptional regulator DIR45_14195 ENOG4107QKR Dehydrogenase DIR45_14205 ENOG4107RUY (E1 component), alpha subunit DIR45_14215 ENOG4105E1F short-chain dehydrogenase reductase DIR45_14220 ENOG4105RHY Pfam:UPF0157 DIR45_14255 ENOG4107SQ8 Glycine betaine DIR45_14260 ENOG4108IJ7 Glycine betaine DIR45_14285 ENOG4105E66 phosphoriboisomerase A DIR45_14290 ENOG41082BV acetyltransferase DIR45_14295 ENOG4108M1A Chitin-binding protein DIR45_14340 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DIR45_14370 ENOG4108Z7F N-acetyltransferase DIR45_14390 ENOG4105EEM helicase DIR45_14410 ENOG4105C9U ATP-dependent DNA helicase RecQ DIR45_14465 ENOG4108M1A Chitin-binding protein DIR45_14485 ENOG4105BZG amino acid carrier protein DIR45_14490 ENOG4105C26 Dehydrogenase DIR45_14495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DIR45_14500 ENOG4105CTU Proline racemase DIR45_14505 ENOG4105CTU Proline racemase DIR45_14510 ENOG41080HI glycine oxidase DIR45_14550 ENOG4107T5V SNARE associated Golgi DIR45_14565 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DIR45_14570 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DIR45_14585 ENOG4105DTQ mandelate racemase muconate lactonizing DIR45_14635 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DIR45_14640 ENOG4105BZU Histidine kinase DIR45_14645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_14680 ENOG4105DPN Oligoendopeptidase f DIR45_14695 ENOG4105EPR degv family DIR45_14740 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DIR45_14745 ENOG4106K7D Major facilitator family transporter DIR45_14765 ENOG4107BMA Transglycosylase associated protein DIR45_14780 ENOG41089UC methyltransferase, type 11 DIR45_14820 ENOG4105CHM Aminotransferase DIR45_14850 ENOG4105DVE abc transporter atp-binding protein DIR45_14900 ENOG4105C02 permease DIR45_14915 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DIR45_14920 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DIR45_14925 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DIR45_14950 ENOG4105E09 nadh pyrophosphatase DIR45_14970 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DIR45_15025 ENOG4107VC0 DNA alkylation repair enzyme DIR45_15040 ENOG4107VMI polysaccharide deacetylase DIR45_15050 ENOG4108ZCF integral membrane protein DIR45_15055 ENOG4105E0M Sulfatase DIR45_15065 ENOG4105C5H ABC transporter DIR45_15080 ENOG41082JN Transcriptional regulator DIR45_15100 ENOG4105CIH Imidazole acetol-phosphate transaminase DIR45_15105 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DIR45_15115 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DIR45_15155 ENOG41069ER domain protein DIR45_15170 ENOG4105EMN RNA polymerase sigma factor DIR45_15195 ENOG4105D4B ABC, transporter DIR45_15205 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DIR45_15215 ENOG4105DKT Transcriptional regulator DIR45_15220 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DIR45_15230 ENOG41061GT Aldolase DIR45_15250 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DIR45_15280 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DIR45_15290 ENOG4105II7 pyrroline-5-carboxylate reductase DIR45_15300 ENOG4107258 Transcriptional regulator DIR45_15315 ENOG4105E0Y RtcB Protein DIR45_15320 ENOG4105ECK Fatty Acid Desaturase DIR45_15325 ENOG4105G6Z alkaline phosphatase DIR45_15335 ENOG4105VMP Transcriptional regulator DIR45_15350 ENOG41090T1 Membrane DIR45_15360 ENOG4108WCX response regulator DIR45_15370 ENOG41068WN DIR45_15395 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DIR45_15420 ENOG4105CKK Glycosyl transferase, family 2 DIR45_15445 ENOG4105CKK Glycosyl transferase, family 2 DIR45_15455 ENOG4105C8Y Acetylornithine aminotransferase DIR45_15495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DIR45_15505 ENOG4108TVJ Nitroreductase DIR45_15510 ENOG4105FS7 Transcriptional regulator DIR45_15550 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DIR45_15565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DIR45_15595 ENOG4108XET gCN5-related N-acetyltransferase DIR45_15675 ENOG410635A Membrane DIR45_15680 ENOG4105KNA -acetyltransferase DIR45_15685 ENOG4108IQI permease DIR45_15695 ENOG4105F1N DNA alkylation repair DIR45_15735 ENOG4107RF6 penicillin-binding protein DIR45_15745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DIR45_15780 ENOG4105P4J Allophanate hydrolase, subunit 1 DIR45_15785 ENOG4107258 Transcriptional regulator DIR45_15795 ENOG4106N3A copper homeostasis protein cutc DIR45_15800 ENOG4108ZRV stage ii sporulation protein p DIR45_15805 ENOG4108ZHR arsR family transcriptional regulator DIR45_15815 ENOG4105FDT acyl-CoA dehydrogenase DIR45_15835 ENOG4105DWD nucleoside recognition domain protein DIR45_15865 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DIR45_15940 ENOG4105E2A Dehydrogenase DIR45_15955 ENOG4108IJ0 Aspartate ammonia-lyase DIR45_15960 ENOG4105HDK L-asparaginase DIR45_15965 ENOG4108IMY Transcriptional regulator DIR45_15975 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DIR45_15980 ENOG4105CUB amino acid DIR45_15990 ENOG4105II7 pyrroline-5-carboxylate reductase DIR45_16000 ENOG4105C6K Malic enzyme DIR45_16015 ENOG4108Q8B Spore germination protein DIR45_16040 ENOG4105CSV Glutaminase DIR45_16075 ENOG4105CGH 5'-nucleotidase DIR45_16080 ENOG4105CH6 catalase DIR45_16090 ENOG4105CHJ isochorismatase hydrolase DIR45_16120 ENOG41090MY MarR family Transcriptional regulator DIR45_16160 ENOG4108606 TspO/MBR family DIR45_16165 ENOG4105CVP deoxyribo-dipyrimidine photolyase DIR45_16180 ENOG4108TWJ NADH dehydrogenase subunit 5 DIR45_16185 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DIR45_16200 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DIR45_16205 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DIR45_16215 ENOG4105DSE periplasmic solute binding protein DIR45_16220 ENOG4105CC5 ABC transporter DIR45_16225 ENOG4105DIK (ABC) transporter DIR45_16255 ENOG4105D6J arsenicaL-resistance protein DIR45_16260 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_16265 ENOG41085FC arsR family transcriptional regulator DIR45_16280 ENOG4105F7F Chaperone DIR45_16295 ENOG4105CHR reductase DIR45_16300 ENOG4108YXU transcriptional regulator AsnC family DIR45_16380 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DIR45_16390 ENOG4105C0R drug resistance transporter emrb qaca subfamily DIR45_16405 ENOG4105IIP Membrane DIR45_16420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_16425 ENOG41062D9 Histidine kinase DIR45_16460 ENOG4105K6H D-cysteine desulfhydrase DIR45_16490 ENOG4105VZ8 Transcriptional regulator DIR45_16505 ENOG4108NNI Beta-lactamase domain-containing protein DIR45_16510 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase DIR45_16520 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DIR45_16525 ENOG4105JQZ Methyltransferase DIR45_16540 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DIR45_16545 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DIR45_16560 ENOG4105BZU Histidine kinase DIR45_16575 ENOG4108U05 Transcriptional regulator DIR45_16590 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DIR45_16595 ENOG4105DJB Major Facilitator Superfamily DIR45_16600 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DIR45_16605 ENOG4107QR9 Iron-sulfur cluster binding protein DIR45_16615 ENOG4106P55 Transcriptional regulator DIR45_16625 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DIR45_16665 ENOG4105TRI Hydrolase DIR45_16700 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DIR45_16730 ENOG4107QJQ Mate efflux family protein DIR45_16750 ENOG4105MZU cell filamentation protein DIR45_16755 ENOG4105EQ0 Major Facilitator superfamily DIR45_16760 ENOG4108JGH Tetr family transcriptional regulator DIR45_16775 ENOG4105C44 Serine transporter DIR45_16780 ENOG4105EJQ L-serine dehydratase DIR45_16800 ENOG4108JPW Aminotransferase DIR45_16825 ENOG4105DVH amino acid DIR45_16845 ENOG4108JQ1 Dehydrogenase DIR45_16865 ENOG4108AEY RNA polymerase sigma factor DIR45_16880 ENOG41082W1 Cupin 2, conserved barrel domain protein DIR45_16890 ENOG410874W AraC family transcriptional regulator DIR45_16945 ENOG4108ISG Major Facilitator DIR45_16955 ENOG4107MII Sugar-specific transcriptional regulator TrmB DIR45_16960 ENOG4105CZM Major Facilitator DIR45_16980 ENOG4105DA5 (ABC) transporter DIR45_16985 ENOG41069JR DIR45_16995 ENOG4105RXJ DIR45_17000 ENOG4105KPY Small multidrug resistance protein DIR45_17005 ENOG4105KBX Transcriptional regulator, TetR family DIR45_17015 ENOG4105CRW Short chain fatty acid transporter DIR45_17025 ENOG4105DYS nad(p)h dehydrogenase (quinone) DIR45_17055 ENOG4108JJB ABC transporter DIR45_17060 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DIR45_17085 ENOG4108K8S endonuclease I DIR45_17100 ENOG41067QW Transcriptional regulator DIR45_17110 ENOG4108Z66 YbaK ebsC protein DIR45_17115 ENOG4105CUT histidyl-tRNA synthetase DIR45_17130 ENOG4105KVH Transcriptional regulator DIR45_17135 ENOG4108RCM Nitroreductase DIR45_17160 ENOG4108PSK reductase DIR45_17170 ENOG4105CJ1 ABC, transporter DIR45_17230 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_17235 ENOG4105DKQ ROK family DIR45_17240 ENOG4106UW1 Major Facilitator superfamily DIR45_17245 ENOG4108UW5 maltose o-acetyltransferase DIR45_17255 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DIR45_17265 ENOG4105C31 Tryptophanyl-tRNA synthetase DIR45_17270 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DIR45_17295 ENOG4105DMQ Methyltransferase DIR45_17305 ENOG4105EV4 Multidrug resistance protein mdtH DIR45_17335 ENOG4105C37 (CBS) domain DIR45_17350 ENOG4105DDN Pentapeptide repeat-containing protein DIR45_17355 ENOG4105XDF Protein of unknown function (DUF1272) DIR45_17365 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DIR45_17370 ENOG4105CMG Carbohydrate kinase DIR45_17375 ENOG4105C6Z Gluconate DIR45_17380 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DIR45_17395 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DIR45_17400 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DIR45_17405 ENOG4105CIS alcohol dehydrogenase DIR45_17410 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DIR45_17430 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DIR45_17435 ENOG4105D4Y metalloprotease DIR45_17455 ENOG4105CV8 reductase DIR45_17460 ENOG4105F27 Major Facilitator DIR45_17480 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DIR45_17485 ENOG4105C44 Serine transporter DIR45_17520 ENOG4105KVH Transcriptional regulator DIR45_17525 ENOG4108TZY GntR Family Transcriptional Regulator DIR45_17530 ENOG4105D9R oxidoreductase DIR45_17535 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DIR45_17540 ENOG4105KVH Transcriptional regulator DIR45_17545 ENOG4105KVH Transcriptional regulator DIR45_17580 ENOG4105JAB phenazine biosynthesis protein, phzf family DIR45_17590 ENOG4105CHR reductase DIR45_17610 ENOG4105KVH Transcriptional regulator DIR45_17680 ENOG4105KAF membrAne DIR45_17710 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DIR45_17730 ENOG4107YXZ hydrolase, family 25 DIR45_17755 ENOG4105ED2 Beta-lactamase DIR45_17765 ENOG4105H3G oxidoreductase DIR45_17800 ENOG4105CIS alcohol dehydrogenase DIR45_17840 ENOG4108TN2 lmbE family DIR45_17850 ENOG4107R3E Citrate transporter DIR45_17880 ENOG4105EHG Permease protein DIR45_17885 ENOG4105DQ5 transport system permease protein DIR45_17890 ENOG4105NX3 Membrane DIR45_17895 ENOG4107ZY0 Phenazine biosynthesis-like protein DIR45_17915 ENOG4107CUJ Protein of unknown function (DUF2690) DIR45_17925 ENOG4107V2S Transcriptional regulator DIR45_17945 ENOG4105C98 muts2 protein DIR45_17960 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DIR45_17965 ENOG4105DPN Oligoendopeptidase f DIR45_17970 ENOG4108A04 Beta-lactamase DIR45_18000 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DIR45_18025 ENOG41082BM Transcriptional regulator, arsr family DIR45_18030 ENOG4105CIS alcohol dehydrogenase DIR45_18065 ENOG4105C09 Bile acid DIR45_18070 ENOG4105CQB FAD linked oxidase domain protein DIR45_18100 ENOG4108UT6 Transferase hexapeptide repeat containing protein DIR45_18110 ENOG4105K64 Glycosyl transferase, family 2 DIR45_18115 ENOG4105E39 Enoyl-CoA hydratase DIR45_18125 ENOG4105KT7 mgtC SapB transporter DIR45_18140 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_18145 ENOG41073R8 VanW family DIR45_18155 ENOG4108R1P DIR45_18175 ENOG4105VEQ Cold shock protein DIR45_18195 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DIR45_18215 ENOG410904N short-chain dehydrogenase reductase DIR45_18240 ENOG4108IA2 Sodium pantothenate symporter DIR45_18250 ENOG4105C26 Dehydrogenase DIR45_18255 ENOG4105CHR reductase DIR45_18265 ENOG4105EWU Squalene--hopene cyclase DIR45_18275 ENOG4105FR1 rard protein DIR45_18280 ENOG410696E Membrane DIR45_18295 ENOG4105D1F ATP-binding protein DIR45_18305 ENOG4108ZAF Molybdopterin DIR45_18310 ENOG4105CVM Molybdenum cofactor synthesis domain protein DIR45_18315 ENOG4105D06 uba thif-type nad fad binding protein DIR45_18320 ENOG4105TMB Formate nitrite transporter DIR45_18335 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DIR45_18340 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DIR45_18350 ENOG4108JB9 formate dehydrogenase DIR45_18360 ENOG4105E1K spore germination protein DIR45_18415 ENOG4107QJT sodium dicarboxylate symporter DIR45_18420 ENOG4108KGH TRANSCRIPTIONal DIR45_18430 ENOG4105EMN RNA polymerase sigma factor DIR45_18450 ENOG4105CIG ABC transporter DIR45_18460 ENOG4105D9R oxidoreductase DIR45_18470 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DIR45_18480 ENOG4105K4P CoA-binding domain protein DIR45_18485 ENOG4105C0H protease DIR45_18490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_18500 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DIR45_18505 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DIR45_18510 ENOG4105W8X HesB YadR YfhF-family protein DIR45_18540 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DIR45_18550 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DIR45_18560 ENOG4108JJA ABC, transporter DIR45_18565 ENOG4108I0Z Aconitate hydratase DIR45_18605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DIR45_18625 ENOG4107F3J Amp-dependent synthetase and ligase DIR45_18630 ENOG4107ZYJ bioY protein DIR45_18635 ENOG4105CEY Amp-dependent synthetase and ligase DIR45_18690 ENOG4107AYK membrAne DIR45_18705 ENOG4105BZU Histidine kinase DIR45_18710 ENOG4105FBA Phospholipase Carboxylesterase DIR45_18715 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DIR45_18720 ENOG4105CK7 Sodium proline symporter DIR45_18725 ENOG4105CBC glutamate synthase DIR45_18730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DIR45_18735 ENOG4108VJ1 Transcriptional regulator (CarD family DIR45_18740 ENOG4108903 Formimidoylglutamase DIR45_18765 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DIR45_18830 ENOG4107QIV Cytochrome c biogenesis protein DIR45_18845 ENOG4107RSM transcriptional regulator DIR45_18850 ENOG4105VAW lrga family DIR45_18855 ENOG41067MG lrgb family DIR45_18880 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DIR45_18895 ENOG4105BZ1 (ABC) transporter DIR45_18900 ENOG4105BZ1 (ABC) transporter DIR45_18925 ENOG4105D7V transposase DIR45_18945 ENOG4105D5T phosphonate abc transporter DIR45_18965 ENOG4108SVB resolvase DIR45_18985 ENOG4105K7K Transcriptional regulator DIR45_19030 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DIR45_19035 ENOG4105XSJ toxin secretion phage lysis holin DIR45_19230 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) DIR45_19345 ENOG4105C5F glutamine synthetase DIR45_19350 ENOG4105KV4 Transcriptional regulator DIR45_19355 ENOG4105CXI aluminum resistance protein DIR45_19360 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DIR45_19365 ENOG4105EN6 Membrane DIR45_19370 ENOG4106F1P AAA ATPase, central domain protein DIR45_19400 ENOG41069ER domain protein DIR45_19410 ENOG4105DM4 PTS System DIR45_19415 ENOG4105DE4 1-phosphofructokinase DIR45_19420 ENOG4105E98 transcriptional regulator DeoR family DIR45_19430 ENOG4108SJC Membrane DIR45_19445 ENOG4105C85 amino acid DIR45_19470 ENOG4105TMB Formate nitrite transporter DIR45_19475 ENOG4105K70 DNA-binding protein DIR45_19485 ENOG4105C59 p-type ATPase DIR45_19490 ENOG410681U heavy metal transport detoxification protein DIR45_19495 ENOG4105VPX protein, conserved in bacteria DIR45_19505 ENOG4105NIV Esterase DIR45_19510 ENOG4105E0A ABC, transporter DIR45_19540 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DIR45_19545 ENOG4105D03 DNA-3-methyladenine glycosylase II DIR45_19575 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_19580 ENOG4105BZU Histidine kinase DIR45_19600 ENOG41067MG lrgb family DIR45_19615 ENOG4107TTQ Alpha beta hydrolase fold DIR45_19620 ENOG4107YEI lmbE family DIR45_19645 ENOG4105F0V Cell wall hydrolase DIR45_19650 ENOG4107R6R udp-galactopyranose mutase DIR45_19655 ENOG4105E0M Sulfatase DIR45_19660 ENOG410890F Dynamin family DIR45_19670 ENOG4107QHE Choloylglycine hydrolase DIR45_19695 ENOG4105DA5 (ABC) transporter DIR45_19720 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DIR45_19725 ENOG4105DQU oxidoreductase, subunit beta DIR45_19730 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DIR45_19735 ENOG4108IGT Dipeptidase DIR45_19740 ENOG4105MCT stage V sporulation protein S DIR45_19745 ENOG4105D48 metallophosphoesterase DIR45_19770 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DIR45_19785 ENOG4105XZV Protein of unknown function (DUF3243) DIR45_19790 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DIR45_19815 ENOG4108JQ9 ABC transporter DIR45_19820 ENOG4105DIH basic membrane DIR45_19825 ENOG4105FDP GntR family transcriptional regulator DIR45_19830 ENOG4107QZI cell division protein FtsK DIR45_19840 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DIR45_19855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DIR45_19865 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DIR45_19870 ENOG4108S0H Dipicolinic acid synthetase, b subunit DIR45_19875 ENOG4105E35 Dipicolinate synthase subunit A DIR45_19890 ENOG4105C1V Peptidase, M16 DIR45_19910 ENOG4105DTN riboflavin biosynthesis protein ribF DIR45_19915 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DIR45_19925 ENOG4105W7A Protein of unknown function (DUF503) DIR45_19935 ENOG4105VHM ribosomal protein DIR45_19940 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DIR45_19945 ENOG4105CHV Transcription elongation factor NusA DIR45_19955 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DIR45_19970 ENOG4105DZP Membrane-associated zinc metalloprotease DIR45_19975 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DIR45_19980 ENOG4105KNE Phosphatidate cytidylyltransferase DIR45_20025 ENOG4108HE4 integrase family DIR45_20035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DIR45_20045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DIR45_20060 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DIR45_20085 ENOG4105VB6 UPF0109 protein DIR45_20105 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DIR45_20110 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DIR45_20125 ENOG4105CHR reductase DIR45_20130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DIR45_20145 ENOG4105CB5 ATP-dependent DNA helicase recG DIR45_20150 ENOG4105DP4 dak2 domain fusion protein ylov DIR45_20155 ENOG4108ZAA Alkaline-shock protein DIR45_20170 ENOG4105FJ0 thiamine DIR45_20175 ENOG4105DJV ribulose-phosphate 3-epimerase DIR45_20180 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DIR45_20185 ENOG4105D9P serine threonine protein kinase DIR45_20190 ENOG4108ZF3 Phosphatase DIR45_20200 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DIR45_20210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DIR45_20215 ENOG4105C25 Primosomal protein n' DIR45_20220 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DIR45_20240 ENOG4105DSJ YicC domain protein DIR45_20250 ENOG4105F23 Fibronectin-binding protein DIR45_20255 ENOG4105DC7 peptidase M24 DIR45_20315 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DIR45_20340 ENOG4105C34 Pseudouridine synthase DIR45_20355 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DIR45_20365 ENOG4105DBK s4 domain protein DIR45_20370 ENOG41067XK integral membrane protein DIR45_20380 ENOG4105DFA alanine racemase domain protein DIR45_20385 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DIR45_20390 ENOG4105WR5 sporulation protein, YlmC YmxH family DIR45_20400 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_20410 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DIR45_20415 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DIR45_20420 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DIR45_20425 ENOG4105D4A Cell wall formation (By similarity) DIR45_20430 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DIR45_20435 ENOG4105CNI cell division protein FtsW DIR45_20450 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DIR45_20455 ENOG4105CJN penicillin-binding protein DIR45_20460 ENOG4105CJN penicillin-binding protein DIR45_20465 ENOG41068DC Essential cell division protein (By similarity) DIR45_20500 ENOG4105KNH Nucleic acid-binding protein DIR45_20550 ENOG4105XSJ toxin secretion phage lysis holin DIR45_20630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DIR45_20640 ENOG4105CAR Terminase, large subunit DIR45_20740 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DIR45_20755 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_20810 ENOG4108IMY Transcriptional regulator DIR45_20850 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) DIR45_20860 ENOG41063PX domain protein DIR45_20865 ENOG4105D78 K07001 NTE family protein DIR45_20870 ENOG4105H20 Sporulation integral membrane protein YlbJ DIR45_20880 ENOG4106H78 methyltransferase DIR45_20900 ENOG4107TB6 phosphoglycerate mutase DIR45_20915 ENOG4106UY4 Inherit from COG: Scp-like extracellular DIR45_20965 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DIR45_20975 ENOG4105CNI cell division protein FtsW DIR45_20990 ENOG4108IAB Phoh family DIR45_21010 ENOG4105QA2 DIR45_21015 ENOG4105CI3 gtp-binding protein typa DIR45_21025 ENOG4105ECY inositol monophosphatase DIR45_21045 ENOG4105CXN decarboxylase DIR45_21095 ENOG4105CPP Dehydrogenase, E1 component DIR45_21110 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DIR45_21130 ENOG4105CN5 Metallo-Beta-Lactamase DIR45_21135 ENOG4107ZYR domain protein DIR45_21170 ENOG4108XRC Protein of unknown function (DUF458) DIR45_21180 ENOG4107IN1 Protein of unknown function (DUF1797) DIR45_21195 ENOG4105EPM Diguanylate phosphodiesterase DIR45_21200 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DIR45_21230 ENOG4105UIN DIR45_21295 ENOG4108HGU Histidine kinase DIR45_21305 ENOG4105CHM Aminotransferase DIR45_21310 ENOG4105FKQ transcriptional regulator DIR45_21315 ENOG4105EG2 ABC transporter, permease DIR45_21325 ENOG4107FKK extracellular solute-binding protein family 1 DIR45_21335 ENOG4105CG3 alpha amylase, catalytic region DIR45_21380 ENOG4105CHU acetyl-coa acetyltransferase DIR45_21420 ENOG4105K7K Transcriptional regulator DIR45_21425 ENOG4105DTD Dehydrogenase DIR45_21435 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DIR45_21445 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DIR45_21470 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DIR45_21495 ENOG4106TD9 Diguanylate cyclase DIR45_21515 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DIR45_21530 ENOG4105CID antiterminator DIR45_21540 ENOG4105FDP GntR family transcriptional regulator DIR45_21550 ENOG4105CE4 GlcNAc 6-P deacetylase DIR45_21595 ENOG4107ZE5 PPIases accelerate the folding of proteins DIR45_21600 ENOG4105PTM secreted protein DIR45_21605 ENOG4105J7I hydrolase DIR45_21615 ENOG4105G6R Stage v sporulation protein ae DIR45_21625 ENOG4105CZ3 stage V sporulation protein ad DIR45_21630 ENOG41090VF Stage v sporulation protein ac DIR45_21650 ENOG4105C8J )-transporter DIR45_21655 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_21665 ENOG41082AN stage II sporulation protein DIR45_21670 ENOG4105DZ1 carboxypeptidase DIR45_21680 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DIR45_21685 ENOG4105DVE abc transporter atp-binding protein DIR45_21720 ENOG4105D7N magnesium and cobalt transport protein CorA DIR45_21745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DIR45_21755 ENOG4105I3K Ferric uptake regulator, Fur family DIR45_21760 ENOG4105MZ9 stage II sporulation protein m DIR45_21780 ENOG4105CPC Aldo Keto reductase DIR45_21790 ENOG4105RHY Pfam:UPF0157 DIR45_21810 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DIR45_21825 ENOG4108YM7 Gcn5-related n-acetyltransferase DIR45_21845 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DIR45_21850 ENOG4108R6K riboflavin synthase, subunit alpha DIR45_21870 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DIR45_21875 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DIR45_21880 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DIR45_21885 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DIR45_21895 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DIR45_21910 ENOG4105DFD Na H antiporter DIR45_21915 ENOG4105CGH 5'-nucleotidase DIR45_21955 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DIR45_21970 ENOG4108IXY short-chain dehydrogenase reductase DIR45_21975 ENOG41069FQ Metallo-beta-lactamase superfamily DIR45_21980 ENOG4105II7 pyrroline-5-carboxylate reductase DIR45_21985 ENOG4105EJQ L-serine dehydratase DIR45_22015 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DIR45_22025 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DIR45_22030 ENOG4105D9U N-acetyltransferase DIR45_22045 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DIR45_22050 ENOG4108QEG Membrane DIR45_22055 ENOG4105CDA abc transporter atp-binding protein DIR45_22060 ENOG4105E5Q amino acid AbC transporter DIR45_22065 ENOG4108HW3 (ABC) transporter DIR45_22080 ENOG4105G7B Protein of unknown function (DUF2992) DIR45_22085 ENOG4105E09 nadh pyrophosphatase DIR45_22100 ENOG4105C7S Dehydrogenase DIR45_22105 ENOG4105CPP Dehydrogenase, E1 component DIR45_22125 ENOG4107RDP Dehydrogenase DIR45_22140 ENOG4108JUB Transcriptional regulator DIR45_22150 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DIR45_22165 ENOG4107QQR Sporulation DIR45_22175 ENOG4105S1Z Stage IV sporulation protein B DIR45_22180 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DIR45_22190 ENOG4105DX0 Hemolysin A DIR45_22200 ENOG4105CTB Polyprenyl synthetase DIR45_22225 ENOG4108ZSR alkaline shock protein DIR45_22230 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DIR45_22255 ENOG410644B Stage III sporulation protein af DIR45_22265 ENOG4105KQ4 Stage iii sporulation protein ad DIR45_22270 ENOG4108CQH stage III sporulation protein AC DIR45_22275 ENOG4105KR5 Stage iii sporulation protein DIR45_22280 ENOG4105CD2 stage iii sporulation protein aa DIR45_22305 ENOG4105DC7 peptidase M24 DIR45_22320 ENOG4105CBJ Metal-dependent enzyme DIR45_22330 ENOG4107YBY Hydrolase DIR45_22350 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DIR45_22355 ENOG4105WZW rhodanese family DIR45_22375 ENOG41080TC multidrug resistance protein DIR45_22415 ENOG4105CJ1 ABC, transporter DIR45_22420 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DIR45_22455 ENOG4105C0D helicase DIR45_22580 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DIR45_22595 ENOG4105C28 cystathionine DIR45_22600 ENOG4105C28 cystathionine DIR45_22620 ENOG4105C5X domain protein DIR45_22630 ENOG4105DKQ ROK family DIR45_22640 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DIR45_22655 ENOG4108UTW Plays a role in the regulation of phosphate uptake DIR45_22660 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DIR45_22665 ENOG4105E2Z phosphate ABC transporter (Permease DIR45_22670 ENOG4105C8U phosphate abc transporter DIR45_22675 ENOG4105PWN phosphate abc transporter DIR45_22680 ENOG4107RF6 penicillin-binding protein DIR45_22690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DIR45_22715 ENOG4105N80 Ferric uptake regulator, Fur family DIR45_22725 ENOG4105FDK ABC transporter DIR45_22730 ENOG4108JYZ YitT family DIR45_22735 ENOG41069ZM Protein of unknown function (DUF2624) DIR45_22760 ENOG4105EGD dinuclear metal center protein, YbgI family DIR45_22775 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_22780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DIR45_22815 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DIR45_22820 ENOG4105KG3 cytidine deaminase DIR45_22825 ENOG4107YR5 Diacylglycerol kinase DIR45_22835 ENOG4105CTJ Metal Dependent Phosphohydrolase DIR45_22840 ENOG4105C9A Phoh family DIR45_22855 ENOG41068P3 sporulation protein YqfC DIR45_22860 ENOG4105KTH gatB Yqey DIR45_22875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DIR45_22880 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DIR45_22900 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DIR45_22910 ENOG4105CSA Coproporphyrinogen iii oxidase DIR45_22915 ENOG4105KVH Transcriptional regulator DIR45_22940 ENOG4105TQK DNA polymerase iii, delta' subunit DIR45_22950 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DIR45_22955 ENOG4108UK2 deaminase DIR45_22960 ENOG4105KQC Competence protein DIR45_22970 ENOG4105DXX methyltransferase DIR45_22980 ENOG4108WF2 Metal Dependent Phosphohydrolase DIR45_22990 ENOG410812S Rna-binding protein DIR45_23000 ENOG4105CQW ribosome biogenesis GTPase YqeH DIR45_23005 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DIR45_23020 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_23040 ENOG4108TVJ Nitroreductase DIR45_23055 ENOG4105G6Z alkaline phosphatase DIR45_23065 ENOG4108MUZ hydrolase DIR45_23100 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DIR45_23105 ENOG4105MIR Phenylalanine 4-monooxygenase DIR45_23115 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_23155 ENOG4105S6R Iron-hydroxamate transporter permease subunit DIR45_23160 ENOG4108V5C ABC transporter DIR45_23170 ENOG4108EKI Dehydrogenase DIR45_23175 ENOG4105C28 cystathionine DIR45_23205 ENOG4107XRG penicillin-binding protein DIR45_23220 ENOG4105CFP Peptidase U32 DIR45_23225 ENOG4105XYU peptidase (U32 family) DIR45_23230 ENOG4108VQJ O-methyltransferase DIR45_23235 ENOG4105HHA aminodeoxychorismate lyase DIR45_23255 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DIR45_23265 ENOG4105C02 permease DIR45_23280 ENOG41060CR DIR45_23285 ENOG4105C7H Helicase, RecD TraA family DIR45_23295 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DIR45_23300 ENOG4105C3J Cysteine desulfurase DIR45_23310 ENOG4105D1H recombination factor protein RarA DIR45_23315 ENOG4108VCI transcription factor, rsfa family DIR45_23320 ENOG4105CUZ uba thif-type nad fad binding protein DIR45_23330 ENOG4105CUT histidyl-tRNA synthetase DIR45_23350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DIR45_23360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DIR45_23370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DIR45_23380 ENOG4105CKP Polysaccharide Biosynthesis Protein DIR45_23385 ENOG4108QG2 Membrane DIR45_23395 ENOG4105VIE preprotein translocase, subunit YajC DIR45_23410 ENOG41061AI Protein of unknown function (DUF2905) DIR45_23425 ENOG4108HUF Transporter DIR45_23435 ENOG4108IPJ Membrane DIR45_23440 ENOG4108IPJ Membrane DIR45_23445 ENOG41082BM Transcriptional regulator, arsr family DIR45_23470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DIR45_23475 ENOG4108IYU L-aspartate oxidase DIR45_23490 ENOG4108RPX mosc domain containing protein DIR45_23495 ENOG4105CQC Prephenate dehydratase DIR45_23525 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DIR45_23540 ENOG4105X36 (ribosomal) protein DIR45_23550 ENOG4105C03 ribonuclease DIR45_23565 ENOG4107QMS site-determining protein DIR45_23580 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DIR45_23585 ENOG4105DFF Rod shape-determining protein mreb DIR45_23610 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DIR45_23615 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DIR45_23625 ENOG41068KH stage VI sporulation protein D DIR45_23635 ENOG4105D52 delta-aminolevulinic acid dehydratase DIR45_23660 ENOG4105K56 Transcriptional regulator DIR45_23680 ENOG4108IUQ atp-dependent protease DIR45_23710 ENOG4108QCI YvbH-like oligomerisation region DIR45_23735 ENOG4105M59 Phosphodiesterase, mj0936 family DIR45_23750 ENOG4108XJQ germination protein DIR45_23760 ENOG4108PCX Major Facilitator DIR45_23770 ENOG4105KBX Transcriptional regulator, TetR family DIR45_23785 ENOG4105PFC Transcriptional regulator DIR45_23800 ENOG4105DZC cytosine deaminase DIR45_23805 ENOG4105DZC cytosine deaminase DIR45_23810 ENOG4105DEF Extracellular solute-binding protein, family 5 DIR45_23815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DIR45_23830 ENOG4108JQ7 (ABC) transporter DIR45_23840 ENOG4105DY9 regulatoR DIR45_23855 ENOG41067S9 phage shock protein C, PspC DIR45_23860 ENOG4108JCI Transcriptional regulator DIR45_23870 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DIR45_23875 ENOG4108Z40 Transcriptional regulator DIR45_23880 ENOG4105RHA ABC transporter, permease DIR45_23885 ENOG4108IUX (ABC) transporter DIR45_23890 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DIR45_23900 ENOG4105E14 MotA TolQ exbB proton channel DIR45_23905 ENOG4108VXD carboxy-peptidase DIR45_23915 ENOG4105E33 succinate dehydrogenase DIR45_23925 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DIR45_23940 ENOG4105K63 Thioredoxin DIR45_23945 ENOG4105C10 Electron transfer flavoprotein DIR45_23950 ENOG4105BZJ Electron transfer flavoprotein DIR45_23955 ENOG41060WC Enoyl-CoA hydratase DIR45_23960 ENOG4107Z3H Transcriptional regulator, TetR family DIR45_23965 ENOG4105CEY Amp-dependent synthetase and ligase DIR45_23980 ENOG4105J76 Periplasmic binding protein DIR45_23985 ENOG4105S6R Iron-hydroxamate transporter permease subunit DIR45_24030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_24045 ENOG4105DR4 Methyltransferase DIR45_24060 ENOG4105KFN sortase, SrtB family DIR45_24065 ENOG4105E0A ABC, transporter DIR45_24080 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DIR45_24090 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DIR45_24100 ENOG4105FE9 pseudouridine synthase DIR45_24115 ENOG4105DCG PHP domain protein DIR45_24150 ENOG4105C5S asparaginyl-tRNA synthetase DIR45_24155 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DIR45_24165 ENOG4108RWN rrna methyltransferase DIR45_24200 ENOG4105C0R drug resistance transporter emrb qaca subfamily DIR45_24205 ENOG4105CW7 secretion protein, HlyD family DIR45_24210 ENOG4108JGH Tetr family transcriptional regulator DIR45_24215 ENOG4105CN9 Peptidase m42 family protein DIR45_24235 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DIR45_24240 ENOG4105C22 threonyL-tRNA synthetase DIR45_24245 ENOG4108TDW sporulation protein YtxC DIR45_24265 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DIR45_24275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DIR45_24280 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DIR45_24290 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DIR45_24295 ENOG4105C2M dna polymerase I DIR45_24300 ENOG4105BZU Histidine kinase DIR45_24305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_24330 ENOG4108HMX isocitrate dehydrogenase (NADP) DIR45_24335 ENOG4105BZN citrate synthase DIR45_24350 ENOG4108REF Sporulation integral membrane protein ytvi DIR45_24355 ENOG4105FS0 cytoplasmic membrane protein DIR45_24380 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DIR45_24385 ENOG4105C6K Malic enzyme DIR45_24390 ENOG4105C0B DNA polymerase III (alpha subunit) DIR45_24395 ENOG4105VV2 DIR45_24405 ENOG4105SFS phosphoesterase RecJ domain protein DIR45_24445 ENOG4105DC7 peptidase M24 DIR45_24485 ENOG4105Z7P Acetyltransferase (GNAT) family DIR45_24490 ENOG41082W1 Cupin 2, conserved barrel domain protein DIR45_24500 ENOG4105VZ8 Transcriptional regulator DIR45_24520 ENOG4107YZX Universal stress protein DIR45_24570 ENOG4108JYZ YitT family DIR45_24590 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DIR45_24600 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DIR45_24605 ENOG4105KBJ sporulation protein ytfj DIR45_24620 ENOG4105EFZ amidohydrolase DIR45_24630 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DIR45_24655 ENOG4106KR7 LysR family Transcriptional regulator DIR45_24675 ENOG4105C28 cystathionine DIR45_24700 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DIR45_24710 ENOG4105EMN RNA polymerase sigma factor DIR45_24730 ENOG4105F1V Acetoin utilization protein DIR45_24735 ENOG4105W87 Cbs domain DIR45_24740 ENOG4105DGU Histone deacetylase DIR45_24750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DIR45_24760 ENOG4107SNB ankyrin repeat protein YahD DIR45_24765 ENOG4105EP9 oxidoreductase DIR45_24795 ENOG4105ETE Transcriptional regulator (LacI family DIR45_24820 ENOG4105C88 aminopeptidase DIR45_24865 ENOG4108VDD TRNA binding domain protein DIR45_24895 ENOG4105C8F Beta-lactamase domain protein DIR45_24910 ENOG4108V15 phosphotransferase enzyme family DIR45_24915 ENOG4108IUM Glycogen debranching enzyme DIR45_24930 ENOG4107QSE Dipeptidase DIR45_24935 ENOG4105YW5 deoR family transcriptional regulator DIR45_24950 ENOG4105CBX hi0933 family DIR45_24990 ENOG4108VJ1 Transcriptional regulator (CarD family DIR45_24995 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DIR45_25000 ENOG4105CSC Glucose uptake protein DIR45_25015 ENOG4108ZAF Molybdopterin DIR45_25020 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DIR45_25025 ENOG4105CVM Molybdenum cofactor synthesis domain protein DIR45_25035 ENOG4105D06 uba thif-type nad fad binding protein DIR45_25040 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DIR45_25060 ENOG41085GJ domain protein DIR45_25070 ENOG4105DWV Homoserine O-trans-acetylase DIR45_25080 ENOG4108B31 Spore germination protein DIR45_25115 ENOG410605W Major Facilitator DIR45_25120 ENOG4107S91 Sodium hydrogen exchanger DIR45_25125 ENOG4105NCW Trka-c domain protein DIR45_25140 ENOG4105C19 ABC transporter DIR45_25160 ENOG4105N5T Radical SAM Protein DIR45_25175 ENOG4105DA5 (ABC) transporter DIR45_25210 ENOG4105E8V Alpha Beta Hydrolase Fold protein DIR45_25215 ENOG4108Z0R Transferase DIR45_25220 ENOG4105YVM Phosphoesterase, PA-phosphatase related DIR45_25225 ENOG4105BZF Glycosyl transferase (Group 1 DIR45_25235 ENOG4108RIR Molybdenum cofactor biosynthesis protein DIR45_25295 ENOG4105EGD dinuclear metal center protein, YbgI family DIR45_25300 ENOG4105BZU Histidine kinase DIR45_25305 ENOG4105BZU Histidine kinase DIR45_25310 ENOG4107S9D Alpha beta hydrolase DIR45_25315 ENOG4107T7U Sulfatase DIR45_25335 ENOG4105D2X ABC transporter substrate-binding protein DIR45_25345 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DIR45_25405 ENOG4108V2W Carbonate dehydratase DIR45_25410 ENOG4105C4M (Ubiquinol oxidase) subunit I DIR45_25415 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DIR45_25465 ENOG41087YS Phage shock protein A DIR45_25500 ENOG4105BZU Histidine kinase DIR45_25505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_25530 ENOG4108UGV hypoxanthine phosphoribosyltransferase DIR45_25535 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DIR45_25570 ENOG4107ZTW SNARE associated Golgi DIR45_25585 ENOG4105C19 ABC transporter DIR45_25590 ENOG41086D8 Transcriptional regulator DIR45_25630 ENOG4105C6Z Gluconate DIR45_25635 ENOG4105FDP GntR family transcriptional regulator DIR45_25655 ENOG41069H0 dihydroorotase EC 3.5.2.3 DIR45_25685 ENOG4105DTQ mandelate racemase muconate lactonizing DIR45_25695 ENOG4108IPT Naphthoate synthase DIR45_25700 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DIR45_25705 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DIR45_25710 ENOG4105E4F Isochorismate synthase DIR45_25715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DIR45_25725 ENOG4105VEQ Cold shock protein DIR45_25750 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DIR45_25760 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DIR45_25785 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DIR45_25885 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DIR45_25930 ENOG4105KT7 mgtC SapB transporter DIR45_25935 ENOG4107PBV potassium channel DIR45_25945 ENOG4107QYV phosphohexose isomerase DIR45_25955 ENOG4105WG9 Conserved Protein DIR45_25965 ENOG4105CHM Aminotransferase DIR45_25970 ENOG4108ZB6 transcriptional regulator AsnC family DIR45_25975 ENOG4105C5I Dehydrogenase DIR45_25980 ENOG4108MUZ hydrolase DIR45_25990 ENOG4105C87 Aminotransferase class I and II DIR45_26000 ENOG4105Y38 Kinase-associated protein B DIR45_26010 ENOG4107R3E Citrate transporter DIR45_26030 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DIR45_26035 ENOG4105KA0 thioesterase Superfamily protein DIR45_26055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DIR45_26075 ENOG41069ER domain protein DIR45_26090 ENOG4105CEP NADH dehydrogenase DIR45_26120 ENOG4105EWC Purine nucleoside phosphorylase DIR45_26140 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DIR45_26165 ENOG4108JJA ABC, transporter DIR45_26170 ENOG4105C4B ABC transporter, permease DIR45_26175 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DIR45_26220 ENOG41083MR nifu domain-containing protein DIR45_26240 ENOG4108W5N phosphatidylglycerophosphatase a DIR45_26250 ENOG4105DYS nad(p)h dehydrogenase (quinone) DIR45_26255 ENOG4105D4U had-superfamily hydrolase, subfamily iia DIR45_26270 ENOG4105CBT Fructose-1,6-bisphosphatase DIR45_26290 ENOG4105MMD transcriptional regulator DIR45_26295 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DIR45_26300 ENOG4107TXC Transcriptional regulator DIR45_26305 ENOG41090T1 Membrane DIR45_26330 ENOG4105FAA peptidase M23 DIR45_26340 ENOG4105KZD Domain of unknown function (DUF1805) DIR45_26345 ENOG4107R8B 5'-nucleotidase DIR45_26375 ENOG4105DIW FeS assembly protein SUFB DIR45_26380 ENOG4108UNV SUF system FeS assembly protein, NifU family DIR45_26385 ENOG4105C9B Cysteine desulfurase DIR45_26390 ENOG4105JRK feS assembly protein SufD DIR45_26395 ENOG4105C3K feS assembly ATPase SufC DIR45_26400 ENOG4105D01 (LipO)protein DIR45_26405 ENOG4105D01 (LipO)protein DIR45_26410 ENOG4108UMI ABC transporter, permease DIR45_26450 ENOG41080E8 Transcriptional regulator, Spx MgsR family DIR45_26505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DIR45_26535 ENOG4108W8B Beta-lactamase domain protein DIR45_26540 ENOG4105C1G acyl-Coa dehydrogenase DIR45_26550 ENOG4105CHU acetyl-coa acetyltransferase DIR45_26570 ENOG4105DZ1 carboxypeptidase DIR45_26590 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DIR45_26610 ENOG4108SUT Major Facilitator Superfamily DIR45_26615 ENOG4107R7I amino acid DIR45_26625 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DIR45_26635 ENOG4107AYK membrAne DIR45_26675 ENOG4107ZTW SNARE associated Golgi DIR45_26685 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DIR45_26690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_26695 ENOG4105BZU Histidine kinase DIR45_26705 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DIR45_26720 ENOG4105VG1 fes assembly suf system protein DIR45_26725 ENOG4105D4Y metalloprotease DIR45_26745 ENOG4107S91 Sodium hydrogen exchanger DIR45_26750 ENOG4105NCW Trka-c domain protein DIR45_26765 ENOG4108RMU ferritin dps family protein DIR45_26780 ENOG4108URH decarboxylase DIR45_26800 ENOG4105D9N nucleoside DIR45_26805 ENOG4105D9N nucleoside DIR45_26820 ENOG4108RYK Nad-dependent epimerase dehydratase DIR45_26850 ENOG4105CV8 reductase DIR45_26855 ENOG4105F27 Major Facilitator DIR45_26860 ENOG4105KVH Transcriptional regulator DIR45_26875 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DIR45_26880 ENOG4105D4A Cell wall formation (By similarity) DIR45_26890 ENOG4105C8Q Methyl-accepting chemotaxis DIR45_26900 ENOG4105WMR Protein CrcB homolog DIR45_26905 ENOG4105WMR Protein CrcB homolog DIR45_26920 ENOG4108MK9 spermidine N(1)-acetyltransferase DIR45_26925 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DIR45_26945 ENOG4108IPW abc transporter atp-binding protein DIR45_26950 ENOG4105CM4 permease protein DIR45_26985 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DIR45_26995 ENOG4105XZU Preprotein translocase, subunit SecG DIR45_27000 ENOG41067MG lrgb family DIR45_27110 ENOG4105EFC phage portal protein HK97 family DIR45_27130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DIR45_27140 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DIR45_27145 ENOG4105CP7 Triose-phosphate isomerase DIR45_27170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_27190 ENOG41090VF Stage v sporulation protein ac DIR45_27195 ENOG4105CZ3 stage V sporulation protein ad DIR45_27210 ENOG4105H67 Protein of unknown function (DUF421) DIR45_27215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DIR45_27225 ENOG4105KRI phosphocarrier protein (HPr DIR45_27235 ENOG4105CHW UPF0052 protein DIR45_27245 ENOG4108Z4K mutator MutT protein DIR45_27255 ENOG4105C3M thioredoxin reductase DIR45_27265 ENOG4108S4C acetyltransferase DIR45_27285 ENOG41086DT Membrane protein of unknown function DIR45_27295 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DIR45_27300 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DIR45_27305 ENOG4105D7V transposase DIR45_27320 ENOG4107TXC Transcriptional regulator DIR45_27355 ENOG4105DUM transcriptional regulator, lysR family DIR45_27365 ENOG4108WS4 fmn reductase DIR45_27380 ENOG4105BZ1 (ABC) transporter DIR45_27390 ENOG4105CN1 protease DIR45_27395 ENOG4105CRP Part of the ABC transporter FtsEX involved in DIR45_27400 ENOG4105CAK Cell division ATP-binding protein ftsE DIR45_27420 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DIR45_27425 ENOG4105MS2 ribosomal subunit Interface protein DIR45_27430 ENOG4105VEQ Cold shock protein DIR45_27435 ENOG41081UC Inherit from COG: Competence protein DIR45_27450 ENOG4105KVH Transcriptional regulator DIR45_27465 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DIR45_27470 ENOG4108KGH TRANSCRIPTIONal DIR45_27475 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DIR45_27480 ENOG4105C6Y Udp-glucose 6-dehydrogenase DIR45_27485 ENOG4105ESV Glycosyl transferase, family 4 DIR45_27495 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DIR45_27510 ENOG410901P UPF0249 protein DIR45_27515 ENOG4105F8D glycoside hydrolase family 4 DIR45_27520 ENOG4105VCP PTS System DIR45_27525 ENOG4105CK1 PTS System DIR45_27535 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DIR45_27540 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DIR45_27545 ENOG4105VCP PTS System DIR45_27555 ENOG4105VZJ PTS System DIR45_27570 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DIR45_27575 ENOG4105ECB domain protein DIR45_27580 ENOG4107RSM transcriptional regulator DIR45_27620 ENOG4105DAA L-lactate DIR45_27630 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DIR45_27645 ENOG4105E0M Sulfatase DIR45_27675 ENOG4107R8N Glycosyl transferase, family 2 DIR45_27685 ENOG4105C94 Transporter DIR45_27695 ENOG41069ER domain protein DIR45_27720 ENOG4105KBK Zinc finger, swim domain protein DIR45_27725 ENOG4105C0D helicase DIR45_27755 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DIR45_27765 ENOG4107RBB ABC transporter, permease DIR45_27770 ENOG4105C19 ABC transporter DIR45_27790 ENOG4105CXY transporter DIR45_27805 ENOG4105BZU Histidine kinase DIR45_27810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_27815 ENOG4105CMR udp-glucose 4-epimerase DIR45_27835 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DIR45_27840 ENOG4105EY8 ABC transporter DIR45_27895 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DIR45_27910 ENOG4105FRN stage II sporulation protein DIR45_27945 ENOG4106778 Protein of unknown function (DUF1146) DIR45_27955 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DIR45_27960 ENOG4105C8S subunit m DIR45_27965 ENOG4105D65 subunit l DIR45_27990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DIR45_27995 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DIR45_28005 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DIR45_28010 ENOG4105BZU Histidine kinase DIR45_28060 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DIR45_28065 ENOG41062M3 atp synthase DIR45_28095 ENOG4108YZG isomerase DIR45_28115 ENOG4108VGI doxx family DIR45_28120 ENOG4107XC4 flavin reductase domain protein, FMN-binding DIR45_28140 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DIR45_28150 ENOG4108ZXQ stage ii sporulation protein r DIR45_28155 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DIR45_28160 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DIR45_28175 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DIR45_28180 ENOG4105CBT Fructose-1,6-bisphosphatase DIR45_28190 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DIR45_28225 ENOG4105C1G acyl-Coa dehydrogenase DIR45_28230 ENOG4105C1G acyl-Coa dehydrogenase DIR45_28235 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DIR45_28245 ENOG4105DF6 Fe-S oxidoreductase DIR45_28260 ENOG4105BZU Histidine kinase DIR45_28285 ENOG4105BZU Histidine kinase DIR45_28290 ENOG4105KCT ABC transporter DIR45_28295 ENOG4108M15 ABC transporter DIR45_28300 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DIR45_28320 ENOG4105IIU Aminopeptidase DIR45_28340 ENOG4105EMN RNA polymerase sigma factor DIR45_28350 ENOG410684U Domain of unknown function (DUF1934) DIR45_28375 ENOG4105CYW agmatinase DIR45_28385 ENOG4105DXB Major Facilitator superfamily DIR45_28390 ENOG4107SWG transcriptional regulator MERR family DIR45_28395 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DIR45_28400 ENOG4105BZ4 penicillin-binding protein DIR45_28410 ENOG4108XFG YwhD family DIR45_28415 ENOG4108Z4T Peptidase M50 DIR45_28420 ENOG41069HH 4-oxalocrotonate tautomerase DIR45_28425 ENOG4105DCI Phosphohydrolase DIR45_28430 ENOG4108MES Periplasmic binding protein DIR45_28435 ENOG4105E0A ABC, transporter DIR45_28440 ENOG4105EHG Permease protein DIR45_28445 ENOG4105DQ5 transport system permease protein DIR45_28455 ENOG4108VCI transcription factor, rsfa family DIR45_28470 ENOG4108IJ2 phosphate acetyltransferase DIR45_28485 ENOG4108VKI Cell wall hydrolase DIR45_28505 ENOG4107SVH Potassium channel protein DIR45_28515 ENOG410667J hydrolase DIR45_28520 ENOG4105VCH membrane DIR45_28530 ENOG4108TU7 Inherit from COG: (ABC) transporter DIR45_28535 ENOG4105CJ1 ABC, transporter DIR45_28540 ENOG41090WU lipolytic protein G-D-S-L family DIR45_28555 ENOG4105D6E homoserine dehydrogenase DIR45_28580 ENOG4108Y4K DNA-binding transcriptional activator DIR45_28590 ENOG4105WH1 Two component transcriptional regulator luxr family DIR45_28600 ENOG4105DWF phosphomethylpyrimidine kinase DIR45_28605 ENOG4105BZU Histidine kinase DIR45_28610 ENOG4105VCD cytoplasmic protein DIR45_28615 ENOG4105D22 carbon starvation protein DIR45_28620 ENOG4105DY9 regulatoR DIR45_28625 ENOG41079KZ Major Facilitator Superfamily DIR45_28645 ENOG4105EN6 Membrane DIR45_28650 ENOG4106YBV Methyl-accepting chemotaxis DIR45_28660 ENOG4108S4H thioesterase Superfamily protein DIR45_28670 ENOG4105JEU Glycosyl transferase, family 2 DIR45_28675 ENOG4105C5H ABC transporter DIR45_28705 ENOG4105CKK Glycosyl transferase, family 2 DIR45_28710 ENOG41067SE Tetr family transcriptional regulator DIR45_28720 ENOG4105E0X reductase DIR45_28725 ENOG4106F5Q Membrane DIR45_28740 ENOG4105DY9 regulatoR DIR45_28745 ENOG4108HRK Histidine kinase DIR45_28750 ENOG4107RGD Major Facilitator superfamily DIR45_28770 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DIR45_28780 ENOG4105IW1 AmiS UreI transporter DIR45_28790 ENOG4105CMR udp-glucose 4-epimerase DIR45_28795 ENOG4108UT2 hemolysin iii DIR45_28805 ENOG4105C1J atp-dependent rna helicase DIR45_28820 ENOG4105DPN Oligoendopeptidase f DIR45_28840 ENOG4105C0H protease DIR45_28845 ENOG4105Q2H domain protein DIR45_28860 ENOG4105BZU Histidine kinase DIR45_28865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DIR45_28895 ENOG4105CDU Replicative dna helicase DIR45_28905 ENOG4105BZR domain protein DIR45_28910 ENOG4108XMW Membrane DIR45_28920 ENOG4108UUM single-stranded DNA-binding protein DIR45_28930 ENOG4105C3G gtp-binding protein DIR45_28935 ENOG4105VDK protein, conserved in bacteria DIR45_28940 ENOG4105D8X mechanosensitive ion channel DIR45_28945 ENOG4108ZDA Sporulation protein YyaC DIR45_28950 ENOG4105FA0 parb-like partition protein DIR45_28955 ENOG4107QJE Chromosome Partitioning Protein DIR45_28975 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DIR45_28985 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DIR45_29010 ENOG4106JUT Streptomycin 3''-adenylyltransferase DIR45_29075 ENOG4105EKQ RNA-directed DNA polymerase DIR45_29170 ENOG4105EKQ RNA-directed DNA polymerase DIR45_29265 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DIR45_29295 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) DIR45_29310 ENOG4108MEK Metal-binding protein YodA DIR45_29335 ENOG4108IBT Inherit from COG: transposase DIR45_29365 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DIR45_29490 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DIR45_29505 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DIR45_29560 ENOG4105C6Y Udp-glucose 6-dehydrogenase DIR45_29565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DIR45_29595 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DIR45_29600 ENOG4106AKK s-layer domain-containing protein DIR45_29620 ENOG4105DHF Membrane DIR45_29850 ENOG4105CNU cell division protein FtsK DIR45_30035 ENOG4107QJE Chromosome Partitioning Protein DIR45_30090 ENOG4105EWC Purine nucleoside phosphorylase DIR45_30175 ENOG4105C3F Signal peptidase i DIR45_30205 ENOG4105N14 lysine exporter protein LysE YggA DIR45_30245 ENOG4108J59 Extracellular solute-binding protein, family 5 DIR45_30260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)