locus-tag	class	description
DIR45_00010	COG0592	DNA-directed DNA polymerase activity
DIR45_00015	COG2501	S4 domain
DIR45_00025	COG0187	DNA topoisomerase II activity
DIR45_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIR45_00065	COG0516	GMP reductase activity
DIR45_00065	COG0517	IMP dehydrogenase activity
DIR45_00070	COG1686	Belongs to the peptidase S11 family
DIR45_00100	COG1428	Deoxynucleoside kinase
DIR45_00105	COG1428	Deoxynucleoside kinase
DIR45_00110	COG1335	isochorismatase
DIR45_00120	COG0590	tRNA wobble adenosine to inosine editing
DIR45_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DIR45_00185	COG1982	Orn Lys Arg decarboxylase major
DIR45_00195	COG0470	DNA polymerase III
DIR45_00200	COG1774	PSP1 C-terminal conserved region
DIR45_00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DIR45_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DIR45_00225	COG2002	toxin-antitoxin pair type II binding
DIR45_00230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_00230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_00235	COG0084	hydrolase, TatD family'
DIR45_00240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DIR45_00255	COG4466	Protein conserved in bacteria
DIR45_00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DIR45_00280	COG0251	oxidation-reduction process
DIR45_00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DIR45_00300	COG0193	aminoacyl-tRNA hydrolase activity
DIR45_00310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DIR45_00315	COG2002	toxin-antitoxin pair type II binding
DIR45_00320	COG2244	polysaccharide biosynthetic process
DIR45_00325	COG3956	TIGRFAM MazG family protein
DIR45_00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DIR45_00350	COG1098	S1 RNA binding domain
DIR45_00365	COG2208	phosphoserine phosphatase activity
DIR45_00370	COG0037	tRNA processing
DIR45_00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DIR45_00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DIR45_00405	COG0512	Glutamine amidotransferase of anthranilate synthase
DIR45_00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DIR45_00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DIR45_00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DIR45_00430	COG1396	sequence-specific DNA binding
DIR45_00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIR45_00465	COG3880	PFAM UvrB UvrC protein
DIR45_00475	COG0542	response to heat
DIR45_00480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DIR45_00490	COG4956	integral membrane protein (PIN domain superfamily)
DIR45_00510	COG1045	serine acetyltransferase
DIR45_00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIR45_00530	COG3688	RNA-binding protein containing a PIN domain
DIR45_00540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DIR45_00545	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIR45_00550	COG0250	Participates in transcription elongation, termination and antitermination
DIR45_00575	COG2813	Specifically methylates the guanine in position
DIR45_00585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DIR45_00590	COG1358	cellular component organization or biogenesis
DIR45_00695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DIR45_00720	COG0201	protein transport
DIR45_00730	COG0024	Methionine aminopeptidase
DIR45_00740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DIR45_00770	COG1122	ATPase activity
DIR45_00775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DIR45_00780	COG0101	tRNA pseudouridine synthase activity
DIR45_00800	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_00805	COG0489	protein tyrosine kinase activity
DIR45_00815	COG2194	sulfuric ester hydrolase activity
DIR45_00820	COG0726	polysaccharide deacetylase
DIR45_00905	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DIR45_00910	COG4856	YbbR-like protein
DIR45_00925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DIR45_00930	COG0596	Alpha beta hydrolase
DIR45_00950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DIR45_00960	COG0823	Involved in the tonB-independent uptake of proteins
DIR45_00960	COG4946	Tricorn protease homolog
DIR45_00960	COG1506	peptidase
DIR45_00995	COG2011	ABC-type metal ion transport system permease component
DIR45_01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_01005	COG1464	Belongs to the NlpA lipoprotein family
DIR45_01025	COG2271	Major facilitator Superfamily
DIR45_01035	COG2814	Major facilitator Superfamily
DIR45_01050	COG0601	transmembrane transport
DIR45_01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_01060	COG0444	Belongs to the ABC transporter superfamily
DIR45_01065	COG4608	Belongs to the ABC transporter superfamily
DIR45_01070	COG4166	transmembrane transport
DIR45_01080	COG2207	Transcriptional regulator
DIR45_01095	COG4166	transmembrane transport
DIR45_01100	COG4166	transmembrane transport
DIR45_01105	COG0656	L-ascorbic acid biosynthetic process
DIR45_01110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_01130	COG4149	molybdate abc transporter
DIR45_01135	COG0725	ABC transporter, periplasmic molybdate-binding protein
DIR45_01140	COG1910	domain protein
DIR45_01155	COG0583	DNA-binding transcription factor activity
DIR45_01160	COG0697	spore germination
DIR45_01175	COG0204	Acyl-transferase
DIR45_01190	COG1609	Transcriptional regulator
DIR45_01200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_01215	COG0084	hydrolase, TatD family'
DIR45_01220	COG5298	Protein conserved in bacteria
DIR45_01245	COG0488	(ABC) transporter
DIR45_01260	COG0747	negative chemotaxis
DIR45_01265	COG0601	transmembrane transport
DIR45_01275	COG0444	Belongs to the ABC transporter superfamily
DIR45_01280	COG4608	Belongs to the ABC transporter superfamily
DIR45_01315	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DIR45_01320	COG0179	Fumarylacetoacetate (FAA) hydrolase
DIR45_01335	COG2814	Major facilitator Superfamily
DIR45_01345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIR45_01355	COG4294	response to UV
DIR45_01360	COG0705	Rhomboid family
DIR45_01360	COG0457	Tetratricopeptide repeat
DIR45_01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DIR45_01375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIR45_01380	COG0864	Transcriptional regulator
DIR45_01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
DIR45_01390	COG2183	response to ionizing radiation
DIR45_01485	COG0802	atpase or kinase
DIR45_01490	COG1214	PFAM Peptidase M22, glycoprotease
DIR45_01495	COG0456	acetyltransferase
DIR45_01500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DIR45_01505	COG0488	(ABC) transporter
DIR45_01520	COG1266	CAAX protease self-immunity
DIR45_01540	COG2252	PERMEase
DIR45_01550	COG5002	protein histidine kinase activity
DIR45_01575	COG1968	undecaprenyl-diphosphatase activity
DIR45_01590	COG2205	protein histidine kinase activity
DIR45_01595	COG0745	RESPONSE REGULATOR receiver
DIR45_01620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DIR45_01625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DIR45_01630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DIR45_01640	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DIR45_01655	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DIR45_01665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DIR45_01675	COG0151	Belongs to the GarS family
DIR45_01705	COG0210	DNA helicase
DIR45_01715	COG4851	CamS sex pheromone cAM373 precursor
DIR45_01735	COG1335	isochorismatase
DIR45_01745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_01750	COG2011	ABC-type metal ion transport system permease component
DIR45_01755	COG1464	Belongs to the NlpA lipoprotein family
DIR45_01775	COG1846	Transcriptional regulator
DIR45_01800	COG1597	lipid kinase activity
DIR45_01805	COG0546	phosphoglycolate phosphatase activity
DIR45_01810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DIR45_01820	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_01825	COG2076	Multidrug Resistance protein
DIR45_01830	COG2309	aminopeptidase activity
DIR45_01845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_01850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIR45_01855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DIR45_01865	COG4807	Protein conserved in bacteria
DIR45_01895	COG1473	amidohydrolase
DIR45_01910	COG0450	alkyl hydroperoxide reductase
DIR45_01915	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DIR45_01925	COG0235	Class ii aldolase
DIR45_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_01935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_01965	COG0166	Belongs to the GPI family
DIR45_02010	COG5002	protein histidine kinase activity
DIR45_02030	COG3541	Predicted nucleotidyltransferase
DIR45_02035	COG2814	Major facilitator Superfamily
DIR45_02040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_02040	COG0723	plastoquinol--plastocyanin reductase activity
DIR45_02050	COG0765	amino acid transport
DIR45_02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_02070	COG0840	transmembrane signaling receptor activity
DIR45_02075	COG0840	transmembrane signaling receptor activity
DIR45_02080	COG0366	Alpha amylase catalytic
DIR45_02085	COG1263	PTS System
DIR45_02085	COG2190	(PTS) system
DIR45_02085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_02115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DIR45_02130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_02140	COG1116	anion transmembrane transporter activity
DIR45_02145	COG0488	(ABC) transporter
DIR45_02190	COG2270	Major facilitator Superfamily
DIR45_02205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_02220	COG2310	stress, protein
DIR45_02225	COG2310	stress, protein
DIR45_02230	COG2310	stress, protein
DIR45_02235	COG0861	Integral membrane protein TerC family
DIR45_02245	COG3853	Toxic anion resistance protein (TelA)
DIR45_02260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DIR45_02270	COG1295	ribonuclease BN
DIR45_02280	COG2217	Heavy metal translocating P-type atpase
DIR45_02285	COG0697	spore germination
DIR45_02305	COG0586	Pfam SNARE associated Golgi protein
DIR45_02320	COG3871	stress protein (general stress protein 26)
DIR45_02325	COG0387	Pfam Sodium calcium exchanger
DIR45_02335	COG0535	radical SAM domain protein
DIR45_02360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DIR45_02365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DIR45_02370	COG0582	viral genome integration into host DNA
DIR45_02375	COG1396	sequence-specific DNA binding
DIR45_02395	COG1396	sequence-specific DNA binding
DIR45_02430	COG1484	DNA-dependent DNA replication
DIR45_02535	COG0582	viral genome integration into host DNA
DIR45_02540	COG0582	viral genome integration into host DNA
DIR45_02685	COG0101	tRNA pseudouridine synthase activity
DIR45_02695	COG3829	transcription factor binding
DIR45_02705	COG0833	amino acid
DIR45_02710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_02740	COG2066	Belongs to the glutaminase family
DIR45_02750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_02750	COG1263	PTS System
DIR45_02755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_02770	COG0463	Glycosyl transferase, family 2
DIR45_02785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_02785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DIR45_02805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DIR45_02825	COG1228	amidohydrolase
DIR45_02830	COG1090	epimerase
DIR45_02860	COG1988	membrane-bound metal-dependent
DIR45_02865	COG1194	a g-specific adenine glycosylase
DIR45_02890	COG1132	(ABC) transporter
DIR45_02895	COG4129	membrane
DIR45_02900	COG0067	glutamate synthase
DIR45_02900	COG0069	glutamate synthase activity
DIR45_02900	COG0070	glutamate synthase
DIR45_02910	COG4555	ABC transporter
DIR45_02930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DIR45_02935	COG0735	belongs to the Fur family
DIR45_03055	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DIR45_03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DIR45_03070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DIR45_03080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DIR45_03095	COG2766	serine protein kinase
DIR45_03125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_03135	COG1585	Membrane protein implicated in regulation of membrane protease activity
DIR45_03140	COG2268	Band 7 protein
DIR45_03150	COG3290	protein histidine kinase activity
DIR45_03155	COG4565	transcriptional regulatory protein
DIR45_03160	COG2851	Citrate transporter
DIR45_03185	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DIR45_03190	COG3842	ATPase activity
DIR45_03195	COG1175	transmembrane transport
DIR45_03200	COG0395	ABC-type sugar transport system, permease component
DIR45_03210	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DIR45_03215	COG0745	RESPONSE REGULATOR receiver
DIR45_03220	COG5002	protein histidine kinase activity
DIR45_03230	COG4990	cell redox homeostasis
DIR45_03240	COG3290	protein histidine kinase activity
DIR45_03245	COG4565	transcriptional regulatory protein
DIR45_03250	COG3493	citrate carrier protein
DIR45_03255	COG0281	malic enzyme
DIR45_03270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_03280	COG5002	protein histidine kinase activity
DIR45_03285	COG0745	RESPONSE REGULATOR receiver
DIR45_03295	COG0456	acetyltransferase
DIR45_03295	COG0454	-acetyltransferase
DIR45_03300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DIR45_03305	COG3383	formate dehydrogenase (NAD+) activity
DIR45_03310	COG2427	Protein of unknown function (DUF1641)
DIR45_03325	COG0531	amino acid
DIR45_03335	COG0640	Transcriptional regulator
DIR45_03340	COG2217	Heavy metal translocating P-type atpase
DIR45_03345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DIR45_03360	COG3227	Zinc metalloprotease (Elastase)
DIR45_03380	COG2720	vancomycin resistance protein
DIR45_03385	COG1316	TRANSCRIPTIONal
DIR45_03390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_03395	COG0346	lactoylglutathione lyase activity
DIR45_03400	COG1253	flavin adenine dinucleotide binding
DIR45_03405	COG1027	Aspartate ammonia-lyase
DIR45_03410	COG1620	l-lactate permease
DIR45_03425	COG3104	oligopeptide transport
DIR45_03430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_03435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_03450	COG2226	methyltransferase
DIR45_03455	COG0156	8-amino-7-oxononanoate synthase activity
DIR45_03460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_03470	COG4548	von Willebrand factor, type A
DIR45_03475	COG0714	Associated with various cellular activities
DIR45_03480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_03500	COG0531	amino acid
DIR45_03505	COG2188	Transcriptional regulator
DIR45_03510	COG1263	PTS System
DIR45_03510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_03515	COG0366	Alpha amylase catalytic
DIR45_03530	COG0697	spore germination
DIR45_03540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_03545	COG1115	amino acid carrier protein
DIR45_03550	COG1126	abc transporter atp-binding protein
DIR45_03555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_03560	COG0765	amino acid transport
DIR45_03565	COG0765	amino acid transport
DIR45_03570	COG0833	amino acid
DIR45_03595	COG2378	regulation of single-species biofilm formation
DIR45_03600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DIR45_03605	COG5002	protein histidine kinase activity
DIR45_03620	COG0659	secondary active sulfate transmembrane transporter activity
DIR45_03635	COG0747	negative chemotaxis
DIR45_03645	COG0601	transmembrane transport
DIR45_03650	COG4608	Belongs to the ABC transporter superfamily
DIR45_03660	COG2271	Major facilitator Superfamily
DIR45_03665	COG1846	Transcriptional regulator
DIR45_03675	COG1609	Transcriptional regulator
DIR45_03680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIR45_03690	COG1129	ABC transporter
DIR45_03695	COG1172	Belongs to the binding-protein-dependent transport system permease family
DIR45_03700	COG1879	ABC-type sugar transport system periplasmic component
DIR45_03705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DIR45_03725	COG1063	alcohol dehydrogenase
DIR45_03740	COG3568	Endonuclease Exonuclease Phosphatase
DIR45_03765	COG1968	undecaprenyl-diphosphatase activity
DIR45_03770	COG0840	transmembrane signaling receptor activity
DIR45_03775	COG3584	3D domain protein
DIR45_03775	COG1388	LysM domain
DIR45_03780	COG1476	TRANSCRIPTIONal
DIR45_03795	COG3104	oligopeptide transport
DIR45_03800	COG1114	Component of the transport system for branched-chain amino acids
DIR45_03815	COG1113	amino acid transport
DIR45_03820	COG2252	PERMEase
DIR45_03845	COG0569	domain protein
DIR45_03845	COG0475	glutathione-regulated potassium exporter activity
DIR45_03860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DIR45_03865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DIR45_03870	COG0833	amino acid
DIR45_03875	COG4990	cell redox homeostasis
DIR45_03890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_03895	COG0697	spore germination
DIR45_03900	COG0531	amino acid
DIR45_03915	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_03920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_03925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DIR45_03925	COG1918	ferrous iron import across plasma membrane
DIR45_03930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DIR45_03935	COG0573	inorganic phosphate transmembrane transporter activity
DIR45_03940	COG0581	inorganic phosphate transmembrane transporter activity
DIR45_03950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIR45_04070	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DIR45_04095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DIR45_04100	COG1116	anion transmembrane transporter activity
DIR45_04105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_04110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_04115	COG0352	thiamine-phosphate diphosphorylase activity
DIR45_04120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_04125	COG2104	thiamine diphosphate biosynthetic process
DIR45_04135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_04140	COG0351	phosphomethylpyrimidine kinase
DIR45_04185	COG2205	protein histidine kinase activity
DIR45_04190	COG2814	Major facilitator Superfamily
DIR45_04195	COG1846	Transcriptional regulator
DIR45_04210	COG2252	PERMEase
DIR45_04215	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_04220	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_04230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DIR45_04235	COG1621	beta-fructofuranosidase activity
DIR45_04240	COG1263	PTS System
DIR45_04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_04245	COG1609	Transcriptional regulator
DIR45_04255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_04260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DIR45_04295	COG0778	Nitroreductase
DIR45_04300	COG2719	SpoVR family
DIR45_04330	COG0446	pyridine nucleotide-disulphide oxidoreductase
DIR45_04335	COG1937	Protein conserved in bacteria
DIR45_04340	COG0425	Belongs to the sulfur carrier protein TusA family
DIR45_04340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_04345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_04345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_04350	COG0425	Belongs to the sulfur carrier protein TusA family
DIR45_04355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_04365	COG2210	Belongs to the sulfur carrier protein TusA family
DIR45_04370	COG0730	response to heat
DIR45_04380	COG1316	TRANSCRIPTIONal
DIR45_04385	COG0604	alcohol dehydrogenase
DIR45_04390	COG1283	sodium-dependent phosphate transmembrane transporter activity
DIR45_04405	COG3711	transcriptional antiterminator
DIR45_04405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_04410	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_04415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_04435	COG3584	3D domain protein
DIR45_04435	COG1388	LysM domain
DIR45_04440	COG0577	efflux transmembrane transporter activity
DIR45_04445	COG1136	(ABC) transporter
DIR45_04455	COG5522	Integral membrane protein (intg_mem_TP0381)
DIR45_04470	COG1114	Component of the transport system for branched-chain amino acids
DIR45_04475	COG3546	catalase activity
DIR45_04510	COG0586	Pfam SNARE associated Golgi protein
DIR45_04545	COG0531	amino acid
DIR45_04550	COG0475	glutathione-regulated potassium exporter activity
DIR45_04560	COG1737	Transcriptional regulator
DIR45_04570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_04570	COG1263	PTS System
DIR45_04580	COG2259	Doxx family
DIR45_04595	COG0697	spore germination
DIR45_04600	COG1522	sequence-specific DNA binding
DIR45_04610	COG2076	Multidrug Resistance protein
DIR45_04615	COG2076	Multidrug Resistance protein
DIR45_04620	COG1309	transcriptional regulator
DIR45_04625	COG2814	Major facilitator Superfamily
DIR45_04630	COG1733	regulation of RNA biosynthetic process
DIR45_04640	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_04645	COG4533	DNA binding
DIR45_04650	COG2211	Major facilitator Superfamily
DIR45_04660	COG0693	protein deglycase activity
DIR45_04665	COG0753	catalase activity
DIR45_04665	COG0693	protein deglycase activity
DIR45_04675	COG0531	amino acid
DIR45_04680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DIR45_04690	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_04710	COG1132	(ABC) transporter
DIR45_04725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_04730	COG0765	amino acid transport
DIR45_04735	COG1126	abc transporter atp-binding protein
DIR45_04750	COG0189	ligase activity
DIR45_04780	COG0028	Belongs to the TPP enzyme family
DIR45_04785	COG3527	Alpha-acetolactate decarboxylase
DIR45_04800	COG0561	phosphatase activity
DIR45_04810	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_04810	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_04820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIR45_04835	COG0659	secondary active sulfate transmembrane transporter activity
DIR45_04855	COG0653	protein targeting
DIR45_04860	COG2244	polysaccharide biosynthetic process
DIR45_04870	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_04875	COG4196	transglutaminase domain protein
DIR45_04890	COG1696	Membrane protein involved in D-alanine export
DIR45_04910	COG1024	Enoyl-CoA hydratase
DIR45_04930	COG1363	Peptidase, m42
DIR45_04950	COG3938	Belongs to the proline racemase family
DIR45_04985	COG0601	transmembrane transport
DIR45_04990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_05000	COG4608	Belongs to the ABC transporter superfamily
DIR45_05010	COG0322	excinuclease ABC activity
DIR45_05045	COG0477	Major facilitator Superfamily
DIR45_05050	COG3290	protein histidine kinase activity
DIR45_05055	COG4565	transcriptional regulatory protein
DIR45_05060	COG3181	Tripartite tricarboxylate transporter family receptor
DIR45_05090	COG0789	Transcriptional regulator
DIR45_05090	COG4978	Transcriptional regulator
DIR45_05105	COG0305	Participates in initiation and elongation during chromosome replication
DIR45_05155	COG0477	Major facilitator Superfamily
DIR45_05230	COG1183	phosphatidylcholine synthase activity
DIR45_05255	COG2376	Dihydroxyacetone kinase
DIR45_05270	COG2376	Dihydroxyacetone kinase
DIR45_05275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_05280	COG1959	2 iron, 2 sulfur cluster binding
DIR45_05315	COG3437	response regulator, receiver
DIR45_05315	COG2770	Histidine kinase
DIR45_05380	COG3237	CsbD-like
DIR45_05405	COG1191	sigma factor activity
DIR45_05415	COG2208	phosphoserine phosphatase activity
DIR45_05420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DIR45_05425	COG2205	protein histidine kinase activity
DIR45_05425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_05425	COG2198	Histidine kinase
DIR45_05425	COG0784	Response regulator, receiver
DIR45_05450	COG0393	Putative heavy-metal-binding
DIR45_05485	COG0420	3'-5' exonuclease activity
DIR45_05490	COG4717	serine-type aminopeptidase activity
DIR45_05510	COG1309	transcriptional regulator
DIR45_05515	COG2814	Major facilitator Superfamily
DIR45_05520	COG0346	lactoylglutathione lyase activity
DIR45_05525	COG0346	lactoylglutathione lyase activity
DIR45_05530	COG0457	Tetratricopeptide repeat
DIR45_05540	COG2267	carboxylic ester hydrolase activity
DIR45_05560	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DIR45_05565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DIR45_05575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DIR45_05620	COG0477	Major facilitator Superfamily
DIR45_05625	COG0477	Major facilitator Superfamily
DIR45_05635	COG3973	AAA domain
DIR45_05640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_05665	COG4980	gas vesicle protein
DIR45_05670	COG0537	adenosine 5'-monophosphoramidase activity
DIR45_05680	COG1131	(ABC) transporter
DIR45_05685	COG4473	ABC transporter
DIR45_05700	COG1309	transcriptional regulator
DIR45_05710	COG3402	PFAM membrane-flanked domain
DIR45_05760	COG3402	PFAM membrane-flanked domain
DIR45_05765	COG3428	Bacterial PH domain
DIR45_05770	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_05780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DIR45_05825	COG1309	transcriptional regulator
DIR45_05830	COG1511	domain protein
DIR45_05855	COG1609	Transcriptional regulator
DIR45_05865	COG1234	tRNA 3'-trailer cleavage
DIR45_05870	COG0095	Lipoate-protein ligase
DIR45_05880	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_05910	COG3209	COG3209 Rhs family protein
DIR45_05955	COG1408	metallophosphoesterase
DIR45_05960	COG1078	dGTPase activity
DIR45_05970	COG1595	DNA-templated transcription, initiation
DIR45_05975	COG2207	Transcriptional regulator
DIR45_05975	COG3708	Transcriptional regulator
DIR45_05990	COG2205	protein histidine kinase activity
DIR45_05995	COG0745	RESPONSE REGULATOR receiver
DIR45_06020	COG0501	Belongs to the peptidase M48B family
DIR45_06025	COG0840	transmembrane signaling receptor activity
DIR45_06030	COG0697	spore germination
DIR45_06045	COG0497	DNA recombination
DIR45_06050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DIR45_06055	COG2224	Isocitrate lyase
DIR45_06065	COG1278	Cold shock
DIR45_06080	COG4903	ComK protein
DIR45_06085	COG0398	Pfam SNARE associated Golgi protein
DIR45_06095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DIR45_06100	COG1074	ATP-dependent DNA helicase activity
DIR45_06145	COG0179	Fumarylacetoacetate (FAA) hydrolase
DIR45_06170	COG0367	asparagine synthase
DIR45_06180	COG0753	catalase activity
DIR45_06185	COG0004	ammonium transporteR
DIR45_06210	COG2996	Protein conserved in bacteria
DIR45_06220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_06230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_06245	COG0561	phosphatase activity
DIR45_06260	COG0542	response to heat
DIR45_06270	COG2267	carboxylic ester hydrolase activity
DIR45_06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DIR45_06300	COG5504	Zn-dependent protease
DIR45_06315	COG0180	Tryptophanyl-tRNA synthetase
DIR45_06330	COG4166	transmembrane transport
DIR45_06335	COG0601	transmembrane transport
DIR45_06340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DIR45_06345	COG0444	Belongs to the ABC transporter superfamily
DIR45_06350	COG4608	Belongs to the ABC transporter superfamily
DIR45_06355	COG0534	Mate efflux family protein
DIR45_06360	COG4166	transmembrane transport
DIR45_06375	COG1393	Belongs to the ArsC family
DIR45_06380	COG0861	Integral membrane protein TerC family
DIR45_06385	COG4862	establishment of competence for transformation
DIR45_06390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_06400	COG1164	Oligoendopeptidase f
DIR45_06415	COG2346	COG2346, Truncated hemoglobins
DIR45_06420	COG4116	CYTH
DIR45_06430	COG2357	RelA SpoT domain protein
DIR45_06435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DIR45_06440	COG0564	pseudouridine synthase activity
DIR45_06460	COG1216	Glycosyl transferase, family 2
DIR45_06500	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DIR45_06515	COG1091	dTDP-4-dehydrorhamnose reductase activity
DIR45_06560	COG2153	protein acetylation
DIR45_06565	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DIR45_06570	COG2382	esterase
DIR45_06585	COG5492	domain, Protein
DIR45_06590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_06605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DIR45_06605	COG0512	Glutamine amidotransferase of anthranilate synthase
DIR45_06640	COG1620	l-lactate permease
DIR45_06645	COG5634	Uncharacterized conserved protein (DUF2278)
DIR45_06705	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_06715	COG1476	TRANSCRIPTIONal
DIR45_06775	COG2226	methyltransferase
DIR45_06790	COG1686	Belongs to the peptidase S11 family
DIR45_06795	COG0681	Belongs to the peptidase S26 family
DIR45_06830	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_06835	COG3842	ATPase activity
DIR45_06840	COG1176	ABC-type spermidine putrescine transport system, permease component I
DIR45_06845	COG1177	transmembrane transport
DIR45_06850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DIR45_06860	COG2409	Drug exporters of the RND superfamily
DIR45_06870	COG0564	pseudouridine synthase activity
DIR45_06880	COG2340	Cysteine-rich secretory protein family
DIR45_06885	COG0247	lactate metabolic process
DIR45_06890	COG0277	FAD linked oxidase domain protein
DIR45_06895	COG3835	regulator
DIR45_06905	COG0745	RESPONSE REGULATOR receiver
DIR45_06910	COG5002	protein histidine kinase activity
DIR45_06915	COG2186	Transcriptional regulator
DIR45_06935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DIR45_06945	COG2116	formate transmembrane transporter activity
DIR45_06950	COG0861	Integral membrane protein TerC family
DIR45_06965	COG2030	dehydratase
DIR45_06985	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_06990	COG3243	poly(R)-hydroxyalkanoic acid synthase
DIR45_07000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DIR45_07020	COG1840	ABC-type Fe3 transport system, periplasmic component
DIR45_07035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIR45_07050	COG1349	DNA-binding transcription factor activity
DIR45_07070	COG2861	carbohydrate metabolic process
DIR45_07080	COG3852	Histidine kinase
DIR45_07085	COG1846	Transcriptional regulator
DIR45_07095	COG2318	DinB family
DIR45_07105	COG5002	protein histidine kinase activity
DIR45_07115	COG0720	synthase
DIR45_07130	COG4873	Protein conserved in bacteria
DIR45_07165	COG1780	Probably involved in ribonucleotide reductase function
DIR45_07185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DIR45_07190	COG1725	Transcriptional regulator
DIR45_07195	COG1131	(ABC) transporter
DIR45_07205	COG1131	(ABC) transporter
DIR45_07210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_07225	COG1522	sequence-specific DNA binding
DIR45_07235	COG1335	isochorismatase
DIR45_07245	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_07250	COG2070	2-Nitropropane dioxygenase
DIR45_07255	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DIR45_07265	COG1696	Membrane protein involved in D-alanine export
DIR45_07290	COG0716	FMN binding
DIR45_07305	COG3173	Aminoglycoside phosphotransferase
DIR45_07330	COG0534	Mate efflux family protein
DIR45_07335	COG1968	undecaprenyl-diphosphatase activity
DIR45_07350	COG1846	Transcriptional regulator
DIR45_07360	COG1301	dicarboxylic acid transport
DIR45_07365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DIR45_07370	COG4709	membrane
DIR45_07375	COG3874	Sporulation protein YtfJ
DIR45_07405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_07410	COG0028	Belongs to the TPP enzyme family
DIR45_07415	COG0440	acetolactate synthase activity
DIR45_07420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIR45_07430	COG0473	3-isopropylmalate dehydrogenase activity
DIR45_07455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DIR45_07490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DIR45_07505	COG1183	phosphatidylcholine synthase activity
DIR45_07510	COG1368	sulfuric ester hydrolase activity
DIR45_07520	COG0019	diaminopimelate decarboxylase activity
DIR45_07540	COG0529	Catalyzes the synthesis of activated sulfate
DIR45_07545	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIR45_07565	COG1648	precorrin-2 dehydrogenase activity
DIR45_07575	COG0733	neurotransmitter:sodium symporter activity
DIR45_07595	COG1757	Na H antiporter
DIR45_07610	COG4758	membrane
DIR45_07615	COG4585	Histidine kinase
DIR45_07620	COG2197	response regulator
DIR45_07630	COG1114	Component of the transport system for branched-chain amino acids
DIR45_07640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DIR45_07665	COG1017	nitric oxide dioxygenase activity
DIR45_07665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DIR45_07685	COG0730	response to heat
DIR45_07690	COG0306	phosphate transporter
DIR45_07695	COG1392	Phosphate transport regulator
DIR45_07700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_07720	COG1801	Protein of unknown function DUF72
DIR45_07730	COG0582	viral genome integration into host DNA
DIR45_07735	COG5002	protein histidine kinase activity
DIR45_07765	COG0392	lysyltransferase activity
DIR45_07765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DIR45_07780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_07785	COG1686	Belongs to the peptidase S11 family
DIR45_07790	COG2715	membrane protein required for spore maturation
DIR45_07795	COG0700	Nucleoside recognition
DIR45_07800	COG1187	pseudouridine synthase activity
DIR45_07810	COG1333	cytochrome c biogenesis protein
DIR45_07815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIR45_07820	COG0745	RESPONSE REGULATOR receiver
DIR45_07825	COG5002	protein histidine kinase activity
DIR45_07830	COG2096	Adenosyltransferase
DIR45_07845	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DIR45_07850	COG1141	Ferredoxin
DIR45_07855	COG4955	Helix-turn-helix domain
DIR45_07860	COG0514	ATP-dependent DNA helicase (RecQ)
DIR45_07865	COG1266	CAAX protease self-immunity
DIR45_07885	COG4862	establishment of competence for transformation
DIR45_07890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DIR45_07910	COG0492	ferredoxin-NADP+ reductase activity
DIR45_07985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_08000	COG0142	geranyltranstransferase activity
DIR45_08010	COG0142	geranyltranstransferase activity
DIR45_08015	COG0105	UTP biosynthetic process
DIR45_08030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIR45_08035	COG0457	Tetratricopeptide repeat
DIR45_08055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DIR45_08070	COG4347	Protein of unknown function (DUF1405)
DIR45_08085	COG2738	Putative neutral zinc metallopeptidase
DIR45_08095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_08105	COG1694	Mazg nucleotide pyrophosphohydrolase
DIR45_08120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_08125	COG0438	transferase activity, transferring glycosyl groups
DIR45_08185	COG3935	DnaD domain protein
DIR45_08190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DIR45_08200	COG4499	WXG100 protein secretion system (Wss), protein YukC
DIR45_08200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_08245	COG4474	Belongs to the UPF0398 family
DIR45_08260	COG0116	Belongs to the methyltransferase superfamily
DIR45_08270	COG1199	ATP-dependent helicase activity
DIR45_08275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DIR45_08285	COG3173	Aminoglycoside phosphotransferase
DIR45_08290	COG0024	Methionine aminopeptidase
DIR45_08300	COG2233	PERMEase
DIR45_08305	COG2311	Membrane
DIR45_08315	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_08325	COG0456	acetyltransferase
DIR45_08360	COG0754	glutathionylspermidine amidase activity
DIR45_08375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_08405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DIR45_08420	COG1215	transferase activity, transferring glycosyl groups
DIR45_08440	COG0454	-acetyltransferase
DIR45_08460	COG0328	RNA-DNA hybrid ribonuclease activity
DIR45_08500	COG1280	lysine exporter protein (LysE YggA)
DIR45_08515	COG3162	membrane
DIR45_08520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_08525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_08540	COG0475	glutathione-regulated potassium exporter activity
DIR45_08545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_08550	COG0789	Transcriptional regulator
DIR45_08550	COG4978	Transcriptional regulator
DIR45_08560	COG2323	membrane
DIR45_08565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DIR45_08620	COG1923	regulation of RNA biosynthetic process
DIR45_08630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIR45_08635	COG1360	Flagellar Motor Protein
DIR45_08640	COG2201	protein-glutamate methylesterase activity
DIR45_08650	COG1776	CheC inhibitor of MCP methylation
DIR45_08650	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_08665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DIR45_08685	COG1256	bacterial-type flagellum assembly
DIR45_08710	COG1815	bacterial-type flagellum-dependent cell motility
DIR45_08715	COG1558	bacterial-type flagellum-dependent cell motility
DIR45_08720	COG1677	Flagellar hook-basal body complex protein FliE
DIR45_08730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_08740	COG1157	protein secretion by the type III secretion system
DIR45_08785	COG0835	chemotaxis
DIR45_08785	COG0784	Response regulator, receiver
DIR45_08795	COG0463	Glycosyl transferase, family 2
DIR45_08835	COG0457	Tetratricopeptide repeat
DIR45_08835	COG0463	Glycosyl transferase, family 2
DIR45_08850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DIR45_08855	COG0741	lytic transglycosylase activity
DIR45_08870	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DIR45_08870	COG1776	CheC inhibitor of MCP methylation
DIR45_08880	COG1338	Plays a role in the flagellum-specific transport system
DIR45_08885	COG1987	bacterial-type flagellum assembly
DIR45_08895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DIR45_08900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DIR45_08905	COG1419	protein localization to endoplasmic reticulum
DIR45_08910	COG4786	Flagellar basal body rod
DIR45_08915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_08940	COG1309	transcriptional regulator
DIR45_08960	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_08990	COG3842	ATPase activity
DIR45_08995	COG0725	ABC transporter, periplasmic molybdate-binding protein
DIR45_09000	COG1177	transmembrane transport
DIR45_09005	COG1234	tRNA 3'-trailer cleavage
DIR45_09035	COG1686	Belongs to the peptidase S11 family
DIR45_09045	COG0406	alpha-ribazole phosphatase activity
DIR45_09075	COG0367	asparagine synthase
DIR45_09105	COG1802	Transcriptional regulator
DIR45_09110	COG0697	spore germination
DIR45_09115	COG0523	cobalamin synthesis protein
DIR45_09125	COG0701	Predicted permease
DIR45_09135	COG0438	transferase activity, transferring glycosyl groups
DIR45_09135	COG1216	Glycosyl transferase, family 2
DIR45_09140	COG1757	Na H antiporter
DIR45_09145	COG0114	fumarate hydratase activity
DIR45_09175	COG3340	Belongs to the peptidase S51 family
DIR45_09195	COG0785	Cytochrome C biogenesis protein
DIR45_09230	COG2733	membrane
DIR45_09270	COG1131	(ABC) transporter
DIR45_09285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_09290	COG0528	UMP kinase activity
DIR45_09300	COG1027	Aspartate ammonia-lyase
DIR45_09305	COG0281	malic enzyme
DIR45_09310	COG4191	Histidine kinase
DIR45_09315	COG0784	Response regulator, receiver
DIR45_09320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_09390	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_09415	COG1966	Carbon starvation protein
DIR45_09430	COG0477	Major facilitator Superfamily
DIR45_09435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_09445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIR45_09460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_09475	COG2244	polysaccharide biosynthetic process
DIR45_09480	COG0733	neurotransmitter:sodium symporter activity
DIR45_09490	COG5566	PFAM Mor transcription activator
DIR45_09495	COG2323	membrane
DIR45_09515	COG2084	Dehydrogenase
DIR45_09535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_09545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_09550	COG0028	Belongs to the TPP enzyme family
DIR45_09555	COG0440	acetolactate synthase activity
DIR45_09560	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DIR45_09570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DIR45_09600	COG3384	dioxygenase
DIR45_09610	COG3279	Response regulator of the LytR AlgR family
DIR45_09615	COG0427	acetyl-CoA hydrolase
DIR45_09635	COG1073	alpha beta
DIR45_09640	COG1131	(ABC) transporter
DIR45_09645	COG4166	transmembrane transport
DIR45_09685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_09705	COG1914	H( )-stimulated, divalent metal cation uptake system
DIR45_09720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DIR45_09755	COG2390	Transcriptional regulator
DIR45_09765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_09770	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DIR45_09785	COG4224	UPF0291 protein
DIR45_09805	COG0006	proline dipeptidase activity
DIR45_09810	COG2132	Multicopper oxidase
DIR45_09840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_09855	COG1276	copper resistance
DIR45_09855	COG2372	response to copper ion
DIR45_09860	COG4549	nuclear export factor GLE1
DIR45_09870	COG0697	spore germination
DIR45_09875	COG0583	DNA-binding transcription factor activity
DIR45_09880	COG1959	2 iron, 2 sulfur cluster binding
DIR45_09885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DIR45_09890	COG0778	Nitroreductase
DIR45_09905	COG0628	permease
DIR45_09910	COG0039	L-malate dehydrogenase activity
DIR45_09915	COG1231	oxidoreductase activity
DIR45_09920	COG0523	cobalamin synthesis protein
DIR45_09935	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_09940	COG2030	dehydratase
DIR45_09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_09960	COG0411	ABC transporter
DIR45_09980	COG0583	DNA-binding transcription factor activity
DIR45_09990	COG1942	4-Oxalocrotonate Tautomerase
DIR45_10000	COG1846	Transcriptional regulator
DIR45_10010	COG1271	oxidase subunit
DIR45_10015	COG1294	oxidase, subunit
DIR45_10020	COG4988	ABC transporter
DIR45_10025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DIR45_10045	COG1686	Belongs to the peptidase S11 family
DIR45_10060	COG0791	NLP P60 protein
DIR45_10060	COG1388	LysM domain
DIR45_10075	COG0745	RESPONSE REGULATOR receiver
DIR45_10090	COG0300	oxidoreductase activity
DIR45_10105	COG0726	polysaccharide deacetylase
DIR45_10130	COG0460	homoserine dehydrogenase
DIR45_10155	COG1316	TRANSCRIPTIONal
DIR45_10165	COG0745	RESPONSE REGULATOR receiver
DIR45_10170	COG5002	protein histidine kinase activity
DIR45_10175	COG0726	polysaccharide deacetylase
DIR45_10185	COG1285	pathogenesis
DIR45_10190	COG1247	-acetyltransferase
DIR45_10200	COG4264	IucA IucC family
DIR45_10205	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_10220	COG1082	Xylose isomerase domain protein TIM barrel
DIR45_10230	COG2814	Major facilitator Superfamily
DIR45_10235	COG1279	arginine transmembrane transporter activity
DIR45_10250	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIR45_10285	COG0577	efflux transmembrane transporter activity
DIR45_10290	COG2002	toxin-antitoxin pair type II binding
DIR45_10295	COG1404	Belongs to the peptidase S8 family
DIR45_10300	COG0640	Transcriptional regulator
DIR45_10305	COG0667	Aldo Keto reductase
DIR45_10340	COG0840	transmembrane signaling receptor activity
DIR45_10360	COG3949	Membrane
DIR45_10365	COG0783	Belongs to the Dps family
DIR45_10380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_10390	COG1231	oxidoreductase activity
DIR45_10400	COG4989	oxidoreductase activity
DIR45_10405	COG0523	cobalamin synthesis protein
DIR45_10410	COG0456	acetyltransferase
DIR45_10490	COG3443	Belongs to the bacterial solute-binding protein 9 family
DIR45_10490	COG0803	Belongs to the bacterial solute-binding protein 9 family
DIR45_10500	COG0702	epimerase
DIR45_10510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIR45_10520	COG4166	transmembrane transport
DIR45_10535	COG0406	alpha-ribazole phosphatase activity
DIR45_10545	COG5337	Spore coat protein CotH
DIR45_10550	COG1051	belongs to the nudix hydrolase family
DIR45_10555	COG0586	Pfam SNARE associated Golgi protein
DIR45_10560	COG2244	polysaccharide biosynthetic process
DIR45_10570	COG0701	Predicted permease
DIR45_10575	COG3689	TIGRFAM TIGR03943 family protein
DIR45_10580	COG1607	acyl-coa hydrolase
DIR45_10590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_10605	COG0702	epimerase
DIR45_10610	COG2839	Protein conserved in bacteria
DIR45_10615	COG1253	flavin adenine dinucleotide binding
DIR45_10630	COG1114	Component of the transport system for branched-chain amino acids
DIR45_10635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_10655	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_10665	COG1876	peptidase activity
DIR45_10675	COG0154	amidase activity
DIR45_10680	COG2211	Major facilitator Superfamily
DIR45_10700	COG0561	phosphatase activity
DIR45_10710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DIR45_10730	COG1819	glycosyl
DIR45_10735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_10740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_10770	COG0456	acetyltransferase
DIR45_10830	COG3874	Sporulation protein YtfJ
DIR45_10855	COG2226	methyltransferase
DIR45_10875	COG1082	Xylose isomerase domain protein TIM barrel
DIR45_10880	COG0346	lactoylglutathione lyase activity
DIR45_10890	COG0604	alcohol dehydrogenase
DIR45_10895	COG1595	DNA-templated transcription, initiation
DIR45_10920	COG0386	Belongs to the glutathione peroxidase family
DIR45_10925	COG1305	Transglutaminase-like
DIR45_10930	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DIR45_10935	COG0714	Associated with various cellular activities
DIR45_10950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DIR45_10955	COG1140	nitrate reductase beta subunit
DIR45_10960	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DIR45_10965	COG2181	nitrate reductase activity
DIR45_10985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIR45_10990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DIR45_10995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_11000	COG0303	'Molybdopterin
DIR45_11005	COG0314	molybdopterin synthase activity
DIR45_11015	COG2223	nitrite transmembrane transporter activity
DIR45_11035	COG1648	precorrin-2 dehydrogenase activity
DIR45_11045	COG1587	Uroporphyrinogen-III synthase
DIR45_11045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DIR45_11050	COG2146	nitrite reductase [NAD(P)H] activity
DIR45_11055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DIR45_11060	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DIR45_11095	COG2359	stage V sporulation protein S
DIR45_11115	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_11130	COG1418	mRNA catabolic process
DIR45_11135	COG0488	(ABC) transporter
DIR45_11150	COG0629	single-stranded DNA binding
DIR45_11165	COG1413	lyase activity
DIR45_11180	COG2136	Putative SAM-dependent methyltransferase
DIR45_11180	COG2521	methyltransferase
DIR45_11185	COG0018	arginyl-trna synthetase
DIR45_11215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIR45_11235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DIR45_11240	COG0017	Asparaginyl-tRNA synthetase
DIR45_11355	COG1929	Belongs to the glycerate kinase type-1 family
DIR45_11360	COG0471	metal ion transport
DIR45_11365	COG0745	RESPONSE REGULATOR receiver
DIR45_11370	COG3850	Histidine kinase
DIR45_11370	COG5002	protein histidine kinase activity
DIR45_11385	COG0733	neurotransmitter:sodium symporter activity
DIR45_11410	COG2610	gluconate transmembrane transporter activity
DIR45_11415	COG1454	alcohol dehydrogenase
DIR45_11420	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_11430	COG0456	acetyltransferase
DIR45_11445	COG1131	(ABC) transporter
DIR45_11460	COG0546	phosphoglycolate phosphatase activity
DIR45_11480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_11495	COG0768	penicillin binding
DIR45_11500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DIR45_11505	COG0204	Acyl-transferase
DIR45_11510	COG1272	protein, Hemolysin III
DIR45_11520	COG0805	protein transport
DIR45_11535	COG1307	EDD domain protein, DegV family
DIR45_11540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DIR45_11545	COG1999	signal sequence binding
DIR45_11550	COG0071	Belongs to the small heat shock protein (HSP20) family
DIR45_11555	COG0367	asparagine synthase
DIR45_11575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_11580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DIR45_11605	COG1051	belongs to the nudix hydrolase family
DIR45_11615	COG0668	transmembrane transport
DIR45_11620	COG4585	Histidine kinase
DIR45_11620	COG2203	Gaf domain
DIR45_11625	COG2197	response regulator
DIR45_11635	COG1064	alcohol dehydrogenase
DIR45_11665	COG1070	Carbohydrate kinase
DIR45_11700	COG0517	IMP dehydrogenase activity
DIR45_11700	COG1125	glycine betaine transport
DIR45_11705	COG1174	glycine betaine transport
DIR45_11740	COG1253	flavin adenine dinucleotide binding
DIR45_11745	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_11750	COG5506	Protein of unknown function (DUF1694)
DIR45_11770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_11775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DIR45_11780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DIR45_11785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_11790	COG0456	acetyltransferase
DIR45_11795	COG3829	transcription factor binding
DIR45_11805	COG1509	lysine 2,3-aminomutase activity
DIR45_11845	COG4326	sporulation control protein
DIR45_11850	COG0671	phosphoesterase, PA-phosphatase related
DIR45_11855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DIR45_11860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_11890	COG1715	Restriction endonuclease
DIR45_11890	COG1787	Restriction endonuclease
DIR45_12010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DIR45_12050	COG4499	WXG100 protein secretion system (Wss), protein YukC
DIR45_12050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_12055	COG2814	Major facilitator Superfamily
DIR45_12060	COG4841	protein insertion into membrane
DIR45_12065	COG0372	Belongs to the citrate synthase family
DIR45_12070	COG2079	MmgE PrpD family protein
DIR45_12075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DIR45_12080	COG1960	acyl-CoA dehydrogenase activity
DIR45_12085	COG2084	Dehydrogenase
DIR45_12090	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_12095	COG1280	lysine exporter protein (LysE YggA)
DIR45_12100	COG1024	Enoyl-CoA hydratase
DIR45_12115	COG0420	3'-5' exonuclease activity
DIR45_12120	COG0419	ATPase involved in DNA repair
DIR45_12155	COG2223	nitrite transmembrane transporter activity
DIR45_12165	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_12170	COG1169	isochorismate synthase
DIR45_12175	COG1021	2,3-dihydroxybenzoate-AMP ligase
DIR45_12180	COG1535	isochorismatase
DIR45_12180	COG3433	isochorismatase activity
DIR45_12190	COG3251	PFAM MbtH domain protein
DIR45_12195	COG2814	Major facilitator Superfamily
DIR45_12210	COG0776	regulation of translation
DIR45_12220	COG2318	DinB family
DIR45_12245	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_12250	COG1187	pseudouridine synthase activity
DIR45_12255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_12275	COG0596	Alpha beta hydrolase
DIR45_12280	COG2814	Major facilitator Superfamily
DIR45_12300	COG2226	methyltransferase
DIR45_12345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_12380	COG1247	-acetyltransferase
DIR45_12420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_12430	COG1278	Cold shock
DIR45_12445	COG0010	Belongs to the arginase family
DIR45_12450	COG0561	phosphatase activity
DIR45_12500	COG0583	DNA-binding transcription factor activity
DIR45_12505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DIR45_12520	COG0583	DNA-binding transcription factor activity
DIR45_12525	COG2258	MOSC domain
DIR45_12540	COG1132	(ABC) transporter
DIR45_12545	COG1132	(ABC) transporter
DIR45_12565	COG1396	sequence-specific DNA binding
DIR45_12595	COG1595	DNA-templated transcription, initiation
DIR45_12625	COG1649	PFAM Uncharacterised BCR, COG1649
DIR45_12655	COG2971	BadF BadG BcrA BcrD
DIR45_12660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_12665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DIR45_12695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_12725	COG1309	transcriptional regulator
DIR45_12740	COG0577	efflux transmembrane transporter activity
DIR45_12740	COG1136	(ABC) transporter
DIR45_12745	COG3615	Tellurite resistance protein tehB
DIR45_12745	COG0500	methyltransferase
DIR45_12755	COG2226	methyltransferase
DIR45_12760	COG3961	Belongs to the TPP enzyme family
DIR45_12765	COG1846	Transcriptional regulator
DIR45_12815	COG2195	Cleaves the N-terminal amino acid of tripeptides
DIR45_12835	COG1595	DNA-templated transcription, initiation
DIR45_12845	COG0768	penicillin binding
DIR45_12855	COG2367	Beta-lactamase
DIR45_12865	COG1609	Transcriptional regulator
DIR45_12875	COG0673	inositol 2-dehydrogenase activity
DIR45_12885	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_12920	COG0737	Belongs to the 5'-nucleotidase family
DIR45_12930	COG0457	Tetratricopeptide repeat
DIR45_12935	COG1476	TRANSCRIPTIONal
DIR45_12950	COG1876	peptidase activity
DIR45_12970	COG1309	transcriptional regulator
DIR45_12990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_13010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_13025	COG1131	(ABC) transporter
DIR45_13035	COG1309	transcriptional regulator
DIR45_13055	COG1960	acyl-CoA dehydrogenase activity
DIR45_13060	COG0439	Biotin carboxylase
DIR45_13065	COG0511	ligase activity, forming carbon-carbon bonds
DIR45_13070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DIR45_13075	COG1024	Enoyl-CoA hydratase
DIR45_13080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DIR45_13085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_13095	COG1247	-acetyltransferase
DIR45_13100	COG0572	uridine kinase
DIR45_13110	COG2318	DinB family
DIR45_13115	COG1686	Belongs to the peptidase S11 family
DIR45_13140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DIR45_13180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_13180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_13195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_13205	COG2814	Major facilitator Superfamily
DIR45_13225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_13245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_13260	COG1063	alcohol dehydrogenase
DIR45_13290	COG3773	Cell wall hydrolase
DIR45_13305	COG0745	RESPONSE REGULATOR receiver
DIR45_13335	COG1136	(ABC) transporter
DIR45_13360	COG0460	homoserine dehydrogenase
DIR45_13365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_13375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DIR45_13470	COG2124	cytochrome p450
DIR45_13505	COG0561	phosphatase activity
DIR45_13515	COG5002	protein histidine kinase activity
DIR45_13525	COG1819	glycosyl
DIR45_13530	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_13540	COG1122	ATPase activity
DIR45_13555	COG2205	protein histidine kinase activity
DIR45_13570	COG0604	alcohol dehydrogenase
DIR45_13585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_13620	COG0693	protein deglycase activity
DIR45_13655	COG2814	Major facilitator Superfamily
DIR45_13675	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_13735	COG2223	nitrite transmembrane transporter activity
DIR45_13750	COG2816	NAD+ diphosphatase activity
DIR45_13755	COG0592	DNA-directed DNA polymerase activity
DIR45_13760	COG1051	belongs to the nudix hydrolase family
DIR45_13795	COG3878	Protein conserved in bacteria
DIR45_13850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DIR45_13865	COG0322	excinuclease ABC activity
DIR45_13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_13935	COG1011	Hydrolase
DIR45_13955	COG0076	glutamate decarboxylase activity
DIR45_13970	COG1523	belongs to the glycosyl hydrolase 13 family
DIR45_13975	COG3227	Zinc metalloprotease (Elastase)
DIR45_13995	COG0201	protein transport
DIR45_14005	COG0697	spore germination
DIR45_14010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_14040	COG4129	membrane
DIR45_14045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_14060	COG2959	enzyme of heme biosynthesis
DIR45_14065	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_14065	COG3773	Cell wall hydrolase
DIR45_14080	COG3483	tryptophan 2,3-dioxygenase activity
DIR45_14085	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DIR45_14090	COG3844	kynureninase activity
DIR45_14095	COG1309	transcriptional regulator
DIR45_14130	COG3284	Transcriptional regulator
DIR45_14150	COG1349	DNA-binding transcription factor activity
DIR45_14170	COG1959	2 iron, 2 sulfur cluster binding
DIR45_14190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIR45_14195	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_14200	COG0022	dehydrogenase e1 component
DIR45_14205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_14215	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_14220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIR45_14220	COG0456	acetyltransferase
DIR45_14255	COG4176	ABC-type proline glycine betaine transport system permease component
DIR45_14260	COG0517	IMP dehydrogenase activity
DIR45_14260	COG4175	Glycine betaine
DIR45_14270	COG0740	serine-type endopeptidase activity
DIR45_14285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DIR45_14290	COG2153	protein acetylation
DIR45_14295	COG3397	chitin binding
DIR45_14310	COG2205	protein histidine kinase activity
DIR45_14340	COG0658	competence protein
DIR45_14340	COG2333	competence protein COMEC
DIR45_14390	COG3973	AAA domain
DIR45_14405	COG2105	PFAM AIG2 family protein
DIR45_14410	COG0514	ATP-dependent DNA helicase (RecQ)
DIR45_14440	COG4637	Psort location Cytoplasmic, score
DIR45_14465	COG3397	chitin binding
DIR45_14480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DIR45_14485	COG1115	amino acid carrier protein
DIR45_14490	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_14495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DIR45_14505	COG3938	Belongs to the proline racemase family
DIR45_14510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DIR45_14550	COG0586	Pfam SNARE associated Golgi protein
DIR45_14565	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DIR45_14570	COG0519	Catalyzes the synthesis of GMP from XMP
DIR45_14575	COG4166	transmembrane transport
DIR45_14585	COG4948	Mandelate Racemase Muconate Lactonizing
DIR45_14635	COG2936	dipeptidyl-peptidase activity
DIR45_14640	COG5002	protein histidine kinase activity
DIR45_14645	COG0745	RESPONSE REGULATOR receiver
DIR45_14680	COG1164	Oligoendopeptidase f
DIR45_14695	COG1307	EDD domain protein, DegV family
DIR45_14720	COG2814	Major facilitator Superfamily
DIR45_14730	COG1664	Polymer-forming cytoskeletal
DIR45_14735	COG0789	Transcriptional regulator
DIR45_14740	COG4533	DNA binding
DIR45_14745	COG0477	Major facilitator Superfamily
DIR45_14745	COG2814	Major facilitator Superfamily
DIR45_14765	COG2261	transglycosylase associated protein
DIR45_14780	COG2226	methyltransferase
DIR45_14820	COG0436	Aminotransferase
DIR45_14825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DIR45_14830	COG5146	pantothenate kinase activity
DIR45_14850	COG1131	(ABC) transporter
DIR45_14900	COG0628	permease
DIR45_14915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_14920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_14925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_14930	COG1116	anion transmembrane transporter activity
DIR45_14970	COG2746	aminoglycoside 3-N-acetyltransferase activity
DIR45_15000	COG0697	spore germination
DIR45_15005	COG2318	DinB family
DIR45_15025	COG4912	Dna alkylation repair
DIR45_15040	COG0726	polysaccharide deacetylase
DIR45_15050	COG0861	Integral membrane protein TerC family
DIR45_15055	COG1368	sulfuric ester hydrolase activity
DIR45_15065	COG0488	(ABC) transporter
DIR45_15080	COG1309	transcriptional regulator
DIR45_15095	COG0287	Prephenate dehydrogenase
DIR45_15100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DIR45_15105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DIR45_15115	COG1605	Chorismate mutase
DIR45_15115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DIR45_15155	COG1388	LysM domain
DIR45_15155	COG3584	3D domain protein
DIR45_15170	COG1595	DNA-templated transcription, initiation
DIR45_15195	COG1879	ABC-type sugar transport system periplasmic component
DIR45_15205	COG1172	Belongs to the binding-protein-dependent transport system permease family
DIR45_15215	COG2390	Transcriptional regulator
DIR45_15220	COG1070	Carbohydrate kinase
DIR45_15250	COG2329	Antibiotic biosynthesis monooxygenase
DIR45_15270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_15280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DIR45_15290	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_15295	COG4187	Peptidase family M20/M25/M40
DIR45_15300	COG1414	Transcriptional regulator
DIR45_15310	COG0833	amino acid
DIR45_15315	COG1690	Belongs to the RtcB family
DIR45_15320	COG3239	Fatty acid desaturase
DIR45_15325	COG1785	Belongs to the alkaline phosphatase family
DIR45_15335	COG3655	Transcriptional regulator
DIR45_15350	COG4377	Putative membrane peptidase family (DUF2324)
DIR45_15360	COG3279	Response regulator of the LytR AlgR family
DIR45_15370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_15375	COG0346	lactoylglutathione lyase activity
DIR45_15395	COG0714	Associated with various cellular activities
DIR45_15420	COG0463	Glycosyl transferase, family 2
DIR45_15445	COG0463	Glycosyl transferase, family 2
DIR45_15455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIR45_15460	COG0753	catalase activity
DIR45_15470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DIR45_15495	COG0714	Associated with various cellular activities
DIR45_15505	COG0778	Nitroreductase
DIR45_15510	COG1846	Transcriptional regulator
DIR45_15550	COG1725	Transcriptional regulator
DIR45_15565	COG0577	efflux transmembrane transporter activity
DIR45_15565	COG1136	(ABC) transporter
DIR45_15590	COG2207	Transcriptional regulator
DIR45_15595	COG0456	acetyltransferase
DIR45_15615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_15635	COG0642	Histidine kinase
DIR45_15640	COG0745	RESPONSE REGULATOR receiver
DIR45_15645	COG0596	Alpha beta hydrolase
DIR45_15675	COG0730	response to heat
DIR45_15685	COG0833	amino acid
DIR45_15695	COG4335	DNA alkylation repair
DIR45_15745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DIR45_15780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DIR45_15785	COG1414	Transcriptional regulator
DIR45_15800	COG0860	N-Acetylmuramoyl-L-alanine amidase
DIR45_15805	COG0640	Transcriptional regulator
DIR45_15815	COG1960	acyl-CoA dehydrogenase activity
DIR45_15850	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DIR45_15865	COG3848	Pyruvate phosphate dikinase
DIR45_15865	COG0574	Belongs to the PEP-utilizing enzyme family
DIR45_15875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_15890	COG5577	PFAM Coat F domain
DIR45_15900	COG3403	YqcI/YcgG family
DIR45_15905	COG1280	lysine exporter protein (LysE YggA)
DIR45_15940	COG1063	alcohol dehydrogenase
DIR45_15955	COG1027	Aspartate ammonia-lyase
DIR45_15960	COG0252	asparaginase activity
DIR45_15965	COG1396	sequence-specific DNA binding
DIR45_15975	COG0322	excinuclease ABC activity
DIR45_15980	COG0531	amino acid
DIR45_15985	COG1114	Component of the transport system for branched-chain amino acids
DIR45_15990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_16000	COG0281	malic enzyme
DIR45_16015	COG0531	amino acid
DIR45_16030	COG0784	Response regulator, receiver
DIR45_16040	COG2066	Belongs to the glutaminase family
DIR45_16045	COG1115	amino acid carrier protein
DIR45_16075	COG0737	Belongs to the 5'-nucleotidase family
DIR45_16080	COG0753	catalase activity
DIR45_16085	COG2267	carboxylic ester hydrolase activity
DIR45_16090	COG1335	isochorismatase
DIR45_16110	COG0583	DNA-binding transcription factor activity
DIR45_16120	COG1846	Transcriptional regulator
DIR45_16125	COG0598	Magnesium transport protein CorA
DIR45_16165	COG0415	Belongs to the DNA photolyase family
DIR45_16170	COG0288	reversible hydration of carbon dioxide
DIR45_16180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIR45_16185	COG5609	conserved protein (DUF2294)
DIR45_16200	COG1575	Belongs to the MenA family. Type 1 subfamily
DIR45_16205	COG2267	carboxylic ester hydrolase activity
DIR45_16215	COG0803	Belongs to the bacterial solute-binding protein 9 family
DIR45_16220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DIR45_16225	COG1121	(ABC) transporter
DIR45_16255	COG0798	PFAM Bile acid sodium symporter
DIR45_16260	COG0346	lactoylglutathione lyase activity
DIR45_16265	COG0640	Transcriptional regulator
DIR45_16280	COG0443	Heat shock 70 kDa protein
DIR45_16300	COG1522	sequence-specific DNA binding
DIR45_16320	COG0346	lactoylglutathione lyase activity
DIR45_16340	COG2169	Transcriptional regulator
DIR45_16390	COG2814	Major facilitator Superfamily
DIR45_16420	COG0745	RESPONSE REGULATOR receiver
DIR45_16425	COG5002	protein histidine kinase activity
DIR45_16425	COG3850	Histidine kinase
DIR45_16460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DIR45_16490	COG1476	TRANSCRIPTIONal
DIR45_16505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_16510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DIR45_16520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_16525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DIR45_16540	COG1136	(ABC) transporter
DIR45_16545	COG0577	efflux transmembrane transporter activity
DIR45_16560	COG3850	Histidine kinase
DIR45_16560	COG5002	protein histidine kinase activity
DIR45_16570	COG2364	Membrane
DIR45_16575	COG1846	Transcriptional regulator
DIR45_16585	COG2808	Putative FMN-binding domain
DIR45_16590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_16595	COG2271	Major facilitator Superfamily
DIR45_16600	COG1556	Lactate utilization protein
DIR45_16605	COG1139	Iron-sulfur cluster binding protein
DIR45_16615	COG0583	DNA-binding transcription factor activity
DIR45_16625	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_16660	COG0673	inositol 2-dehydrogenase activity
DIR45_16665	COG0561	phosphatase activity
DIR45_16675	COG1609	Transcriptional regulator
DIR45_16680	COG0457	Tetratricopeptide repeat
DIR45_16700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIR45_16730	COG0534	Mate efflux family protein
DIR45_16750	COG2184	nucleotidyltransferase activity
DIR45_16755	COG2814	Major facilitator Superfamily
DIR45_16760	COG1309	transcriptional regulator
DIR45_16775	COG0814	amino acid
DIR45_16780	COG1760	l-serine dehydratase
DIR45_16800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DIR45_16805	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DIR45_16820	COG1522	sequence-specific DNA binding
DIR45_16825	COG0531	amino acid
DIR45_16845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DIR45_16865	COG1595	DNA-templated transcription, initiation
DIR45_16880	COG0662	Cupin 2, conserved barrel domain protein
DIR45_16890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_16890	COG2207	Transcriptional regulator
DIR45_16945	COG0477	Major facilitator Superfamily
DIR45_16955	COG1846	Transcriptional regulator
DIR45_16960	COG2814	Major facilitator Superfamily
DIR45_16975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_16980	COG1131	(ABC) transporter
DIR45_17000	COG2076	Multidrug Resistance protein
DIR45_17005	COG1309	transcriptional regulator
DIR45_17015	COG2031	fatty acid transporter
DIR45_17025	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_17055	COG1122	ATPase activity
DIR45_17060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DIR45_17075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DIR45_17080	COG1288	antiporter activity
DIR45_17085	COG2356	endonuclease I
DIR45_17100	COG3620	sequence-specific DNA binding
DIR45_17105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_17110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DIR45_17115	COG0124	histidyl-tRNA synthetase
DIR45_17130	COG1733	regulation of RNA biosynthetic process
DIR45_17135	COG0778	Nitroreductase
DIR45_17160	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_17170	COG1131	(ABC) transporter
DIR45_17195	COG1011	Hydrolase
DIR45_17230	COG0346	lactoylglutathione lyase activity
DIR45_17235	COG1940	carbohydrate kinase activity
DIR45_17240	COG0738	Major facilitator superfamily
DIR45_17245	COG0110	maltose O-acetyltransferase activity
DIR45_17255	COG1136	(ABC) transporter
DIR45_17265	COG0180	Tryptophanyl-tRNA synthetase
DIR45_17270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DIR45_17275	COG0628	permease
DIR45_17295	COG2226	methyltransferase
DIR45_17305	COG0477	Major facilitator Superfamily
DIR45_17335	COG1253	flavin adenine dinucleotide binding
DIR45_17340	COG0789	Transcriptional regulator
DIR45_17345	COG0697	spore germination
DIR45_17350	COG1357	PFAM Pentapeptide repeats (8 copies)
DIR45_17355	COG3813	Protein conserved in bacteria
DIR45_17365	COG2706	6-phosphogluconolactonase activity
DIR45_17370	COG1070	Carbohydrate kinase
DIR45_17380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DIR45_17385	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DIR45_17395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DIR45_17400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DIR45_17405	COG0604	alcohol dehydrogenase
DIR45_17410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DIR45_17430	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_17455	COG0656	L-ascorbic acid biosynthetic process
DIR45_17460	COG2814	Major facilitator Superfamily
DIR45_17480	COG0346	lactoylglutathione lyase activity
DIR45_17485	COG0814	amino acid
DIR45_17510	COG1393	Belongs to the ArsC family
DIR45_17520	COG1733	regulation of RNA biosynthetic process
DIR45_17525	COG2188	Transcriptional regulator
DIR45_17530	COG0673	inositol 2-dehydrogenase activity
DIR45_17535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DIR45_17540	COG1733	regulation of RNA biosynthetic process
DIR45_17545	COG1733	regulation of RNA biosynthetic process
DIR45_17560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_17580	COG0384	phenazine biosynthesis protein PhzF
DIR45_17590	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_17600	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_17610	COG1733	regulation of RNA biosynthetic process
DIR45_17645	COG1191	sigma factor activity
DIR45_17660	COG1309	transcriptional regulator
DIR45_17680	COG3152	Membrane
DIR45_17710	COG1151	hydroxylamine reductase activity
DIR45_17725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_17730	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_17730	COG3757	hydrolase, family 25
DIR45_17765	COG2072	flavoprotein involved in K transport
DIR45_17800	COG0604	alcohol dehydrogenase
DIR45_17805	COG1113	amino acid transport
DIR45_17810	COG2814	Major facilitator Superfamily
DIR45_17845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_17850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_17880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_17885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_17890	COG3739	integral membrane protein
DIR45_17895	COG0384	phenazine biosynthesis protein PhzF
DIR45_17925	COG0583	DNA-binding transcription factor activity
DIR45_17945	COG1193	negative regulation of DNA recombination
DIR45_17960	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DIR45_17965	COG1164	Oligoendopeptidase f
DIR45_17970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DIR45_18000	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_18025	COG0640	Transcriptional regulator
DIR45_18030	COG0604	alcohol dehydrogenase
DIR45_18050	COG2808	Putative FMN-binding domain
DIR45_18065	COG0385	Bile acid
DIR45_18070	COG0277	FAD linked oxidase domain protein
DIR45_18110	COG1216	Glycosyl transferase, family 2
DIR45_18115	COG1024	Enoyl-CoA hydratase
DIR45_18125	COG1285	pathogenesis
DIR45_18140	COG2514	catechol 2,3-dioxygenase activity
DIR45_18145	COG2720	vancomycin resistance protein
DIR45_18175	COG1278	Cold shock
DIR45_18185	COG0716	FMN binding
DIR45_18215	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_18240	COG4145	pantothenate transmembrane transporter activity
DIR45_18250	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_18255	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_18265	COG1657	PFAM Prenyltransferase squalene oxidase
DIR45_18270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DIR45_18275	COG2962	Rard protein
DIR45_18280	COG3326	Membrane
DIR45_18295	COG0489	protein tyrosine kinase activity
DIR45_18305	COG0314	molybdopterin synthase activity
DIR45_18310	COG0303	'Molybdopterin
DIR45_18315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_18320	COG2116	formate transmembrane transporter activity
DIR45_18335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DIR45_18340	COG5609	conserved protein (DUF2294)
DIR45_18345	COG2427	Protein of unknown function (DUF1641)
DIR45_18350	COG3383	formate dehydrogenase (NAD+) activity
DIR45_18360	COG0697	spore germination
DIR45_18400	COG2226	methyltransferase
DIR45_18405	COG4166	transmembrane transport
DIR45_18410	COG4166	transmembrane transport
DIR45_18415	COG1301	dicarboxylic acid transport
DIR45_18420	COG1316	TRANSCRIPTIONal
DIR45_18430	COG1595	DNA-templated transcription, initiation
DIR45_18450	COG1131	(ABC) transporter
DIR45_18460	COG0673	inositol 2-dehydrogenase activity
DIR45_18465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DIR45_18470	COG0187	DNA topoisomerase II activity
DIR45_18480	COG1832	CoA-binding protein
DIR45_18485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_18490	COG0745	RESPONSE REGULATOR receiver
DIR45_18505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DIR45_18510	COG4841	protein insertion into membrane
DIR45_18515	COG0824	Thioesterase
DIR45_18550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_18560	COG2274	protein secretion by the type I secretion system
DIR45_18565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DIR45_18575	COG0726	polysaccharide deacetylase
DIR45_18605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_18620	COG0183	Belongs to the thiolase family
DIR45_18625	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_18630	COG1268	BioY protein
DIR45_18635	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_18690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_18705	COG5002	protein histidine kinase activity
DIR45_18710	COG0400	carboxylic ester hydrolase activity
DIR45_18715	COG0346	lactoylglutathione lyase activity
DIR45_18720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DIR45_18725	COG0069	glutamate synthase activity
DIR45_18730	COG1902	pentaerythritol trinitrate reductase activity
DIR45_18735	COG1329	Transcriptional regulator
DIR45_18740	COG0010	Belongs to the arginase family
DIR45_18765	COG2226	methyltransferase
DIR45_18825	COG4846	Membrane protein involved in cytochrome C biogenesis
DIR45_18830	COG0785	Cytochrome C biogenesis protein
DIR45_18845	COG0583	DNA-binding transcription factor activity
DIR45_18850	COG1380	Effector of murein hydrolase LrgA
DIR45_18855	COG1346	cytolysis
DIR45_18880	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_18880	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_18895	COG1132	(ABC) transporter
DIR45_18900	COG1132	(ABC) transporter
DIR45_18940	COG3639	organic phosphonate transmembrane transporter activity
DIR45_18945	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DIR45_18965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DIR45_18985	COG1695	Transcriptional regulator
DIR45_19030	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_19030	COG1388	LysM domain
DIR45_19030	COG5632	N-Acetylmuramoyl-L-alanine amidase
DIR45_19035	COG4824	toxin secretion phage lysis holin
DIR45_19185	COG1595	DNA-templated transcription, initiation
DIR45_19230	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DIR45_19320	COG1396	sequence-specific DNA binding
DIR45_19345	COG0174	glutamine synthetase
DIR45_19350	COG0789	Transcriptional regulator
DIR45_19355	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DIR45_19360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DIR45_19365	COG2860	membrane
DIR45_19370	COG0464	growth
DIR45_19400	COG1388	LysM domain
DIR45_19400	COG3584	3D domain protein
DIR45_19410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DIR45_19410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DIR45_19410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_19415	COG1105	Belongs to the carbohydrate kinase PfkB family
DIR45_19420	COG1349	DNA-binding transcription factor activity
DIR45_19430	COG2322	membrane
DIR45_19445	COG1113	amino acid transport
DIR45_19465	COG1408	metallophosphoesterase
DIR45_19470	COG2116	formate transmembrane transporter activity
DIR45_19485	COG2217	Heavy metal translocating P-type atpase
DIR45_19490	COG2608	mercury ion transmembrane transporter activity
DIR45_19495	COG1937	Protein conserved in bacteria
DIR45_19505	COG2819	hydrolase of the alpha beta superfamily
DIR45_19510	COG1120	ATPase activity
DIR45_19515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_19520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_19535	COG2169	Transcriptional regulator
DIR45_19540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DIR45_19545	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DIR45_19555	COG2364	Membrane
DIR45_19575	COG0346	lactoylglutathione lyase activity
DIR45_19580	COG5001	Diguanylate cyclase
DIR45_19580	COG3300	MHYT domain
DIR45_19600	COG1346	cytolysis
DIR45_19605	COG1380	Effector of murein hydrolase LrgA
DIR45_19610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DIR45_19615	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_19615	COG0596	Alpha beta hydrolase
DIR45_19620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DIR45_19640	COG1404	Belongs to the peptidase S8 family
DIR45_19645	COG3773	Cell wall hydrolase
DIR45_19650	COG0562	UDP-galactopyranose mutase
DIR45_19655	COG1368	sulfuric ester hydrolase activity
DIR45_19660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DIR45_19670	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DIR45_19715	COG4550	Control of competence regulator ComK, YlbF/YmcA
DIR45_19720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIR45_19725	COG1013	pyruvate-flavodoxin oxidoreductase activity
DIR45_19730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DIR45_19730	COG0674	pyruvate-flavodoxin oxidoreductase activity
DIR45_19740	COG2359	stage V sporulation protein S
DIR45_19745	COG1692	metallophosphoesterase
DIR45_19770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DIR45_19775	COG1426	Protein conserved in bacteria
DIR45_19790	COG0300	oxidoreductase activity
DIR45_19795	COG0612	Peptidase, M16
DIR45_19800	COG0612	Peptidase, M16
DIR45_19825	COG2188	Transcriptional regulator
DIR45_19830	COG1674	ftsk spoiiie
DIR45_19840	COG0740	serine-type endopeptidase activity
DIR45_19845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_19860	COG0527	aspartate kinase activity
DIR45_19865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DIR45_19870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DIR45_19875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DIR45_19885	COG1873	PFAM PRC-barrel domain
DIR45_19890	COG0612	Peptidase, M16
DIR45_19895	COG0726	polysaccharide deacetylase
DIR45_19910	COG0196	riboflavin kinase activity
DIR45_19915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DIR45_19925	COG1550	Protein conserved in bacteria
DIR45_19935	COG1358	cellular component organization or biogenesis
DIR45_19940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DIR45_19945	COG0195	Participates in both transcription termination and antitermination
DIR45_19970	COG0750	zinc metalloprotease
DIR45_19975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DIR45_19980	COG4589	Belongs to the CDS family
DIR45_19995	COG0528	UMP kinase activity
DIR45_20025	COG4974	Belongs to the 'phage' integrase family
DIR45_20035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DIR45_20045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DIR45_20085	COG1837	Belongs to the UPF0109 family
DIR45_20095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DIR45_20105	COG0552	protein localization to endoplasmic reticulum
DIR45_20110	COG1196	nuclear chromosome segregation
DIR45_20125	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_20130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DIR45_20145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DIR45_20150	COG1461	Dihydroxyacetone kinase
DIR45_20155	COG1302	Protein conserved in bacteria
DIR45_20170	COG1564	THIamine pyrophosphokinase
DIR45_20175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DIR45_20180	COG1162	GTPase activity
DIR45_20185	COG2815	serine threonine protein kinase
DIR45_20185	COG0515	serine threonine protein kinase
DIR45_20190	COG0631	protein serine/threonine phosphatase activity
DIR45_20200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DIR45_20200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DIR45_20210	COG0242	peptide deformylase activity
DIR45_20215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DIR45_20220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DIR45_20230	COG0194	GDP metabolic process
DIR45_20240	COG1561	YicC-like family, N-terminal region
DIR45_20245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DIR45_20255	COG0006	proline dipeptidase activity
DIR45_20275	COG3069	C4-dicarboxylate transmembrane transporter activity
DIR45_20315	COG0505	Belongs to the CarA family
DIR45_20340	COG0564	pseudouridine synthase activity
DIR45_20355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DIR45_20360	COG3599	regulation of cell shape
DIR45_20365	COG2302	S4 RNA-binding domain
DIR45_20370	COG0762	integral membrane protein
DIR45_20380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DIR45_20390	COG1873	PFAM PRC-barrel domain
DIR45_20395	COG1191	sigma factor activity
DIR45_20400	COG1191	sigma factor activity
DIR45_20410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DIR45_20415	COG0849	cell division
DIR45_20420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DIR45_20425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DIR45_20430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DIR45_20435	COG0772	Belongs to the SEDS family
DIR45_20450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DIR45_20455	COG0768	penicillin binding
DIR45_20465	COG4839	cell division protein FtsL
DIR45_20480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DIR45_20500	COG1399	metal-binding, possibly nucleic acid-binding protein
DIR45_20550	COG4824	toxin secretion phage lysis holin
DIR45_20640	COG4626	Terminase
DIR45_20640	COG1802	Transcriptional regulator
DIR45_20665	COG0582	viral genome integration into host DNA
DIR45_20755	COG1191	sigma factor activity
DIR45_20780	COG1484	DNA-dependent DNA replication
DIR45_20810	COG1396	sequence-specific DNA binding
DIR45_20830	COG1396	sequence-specific DNA binding
DIR45_20850	COG0582	viral genome integration into host DNA
DIR45_20860	COG3480	Lon protease (S16) C-terminal proteolytic domain
DIR45_20865	COG1752	Esterase of the alpha-beta hydrolase superfamily
DIR45_20870	COG3314	Sporulation integral membrane protein YlbJ
DIR45_20880	COG0742	ribosomal rna small subunit methyltransferase
DIR45_20895	COG3679	Belongs to the UPF0342 family
DIR45_20900	COG0406	alpha-ribazole phosphatase activity
DIR45_20915	COG2340	Cysteine-rich secretory protein family
DIR45_20930	COG3336	cytochrome c oxidase
DIR45_20965	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DIR45_20975	COG0772	Belongs to the SEDS family
DIR45_20980	COG4838	Belongs to the UPF0358 family
DIR45_20985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DIR45_20990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DIR45_21000	COG4896	Protein conserved in bacteria
DIR45_21025	COG0483	inositol monophosphate 1-phosphatase activity
DIR45_21045	COG1982	Orn Lys Arg decarboxylase major
DIR45_21095	COG0022	dehydrogenase e1 component
DIR45_21100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_21110	COG0242	peptide deformylase activity
DIR45_21130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DIR45_21135	COG0569	domain protein
DIR45_21155	COG0583	DNA-binding transcription factor activity
DIR45_21160	COG0517	IMP dehydrogenase activity
DIR45_21170	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DIR45_21180	COG4703	Protein of unknown function (DUF1797)
DIR45_21195	COG2200	EAL domain
DIR45_21200	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_21205	COG1408	metallophosphoesterase
DIR45_21260	COG2814	Major facilitator Superfamily
DIR45_21280	COG3209	COG3209 Rhs family protein
DIR45_21295	COG2205	protein histidine kinase activity
DIR45_21305	COG0436	Aminotransferase
DIR45_21310	COG1609	Transcriptional regulator
DIR45_21315	COG3833	ABC-type maltose transport systems, permease component
DIR45_21320	COG1175	transmembrane transport
DIR45_21325	COG2182	Extracellular solute-binding protein
DIR45_21335	COG0366	Alpha amylase catalytic
DIR45_21340	COG3842	ATPase activity
DIR45_21380	COG0183	Belongs to the thiolase family
DIR45_21420	COG1695	Transcriptional regulator
DIR45_21425	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_21445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DIR45_21450	COG0436	Aminotransferase
DIR45_21470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DIR45_21495	COG3706	GGDEF domain
DIR45_21500	COG0778	Nitroreductase
DIR45_21525	COG2190	(PTS) system
DIR45_21525	COG1263	PTS System
DIR45_21525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DIR45_21530	COG3711	transcriptional antiterminator
DIR45_21550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DIR45_21580	COG1547	Domain of unknown function (DUF309)
DIR45_21585	COG0456	acetyltransferase
DIR45_21595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DIR45_21600	COG4086	secreted protein
DIR45_21605	COG0561	phosphatase activity
DIR45_21610	COG0697	spore germination
DIR45_21625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_21650	COG0733	neurotransmitter:sodium symporter activity
DIR45_21670	COG1686	Belongs to the peptidase S11 family
DIR45_21680	COG1725	Transcriptional regulator
DIR45_21685	COG1131	(ABC) transporter
DIR45_21705	COG1846	Transcriptional regulator
DIR45_21720	COG0598	Magnesium transport protein CorA
DIR45_21745	COG4974	Belongs to the 'phage' integrase family
DIR45_21755	COG0735	belongs to the Fur family
DIR45_21760	COG1300	Membrane
DIR45_21780	COG0667	Aldo Keto reductase
DIR45_21785	COG0656	L-ascorbic acid biosynthetic process
DIR45_21790	COG0456	acetyltransferase
DIR45_21790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DIR45_21800	COG0737	Belongs to the 5'-nucleotidase family
DIR45_21800	COG1525	nuclease
DIR45_21800	COG4085	toxin activity
DIR45_21810	COG0596	Alpha beta hydrolase
DIR45_21815	COG2056	Na+-H+ antiporter family
DIR45_21825	COG0456	acetyltransferase
DIR45_21830	COG1073	alpha beta
DIR45_21845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIR45_21845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DIR45_21850	COG0307	riboflavin synthase, alpha
DIR45_21870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DIR45_21875	COG4106	trans-aconitate 2-methyltransferase activity
DIR45_21880	COG2226	methyltransferase
DIR45_21880	COG1073	alpha beta
DIR45_21885	COG0156	8-amino-7-oxononanoate synthase activity
DIR45_21895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DIR45_21915	COG0737	Belongs to the 5'-nucleotidase family
DIR45_21925	COG1522	sequence-specific DNA binding
DIR45_21945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DIR45_21955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DIR45_21970	COG0300	oxidoreductase activity
DIR45_21975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_21980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_21985	COG1760	l-serine dehydratase
DIR45_21990	COG1760	l-serine dehydratase
DIR45_22015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DIR45_22025	COG2195	Cleaves the N-terminal amino acid of tripeptides
DIR45_22030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_22045	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_22050	COG4129	membrane
DIR45_22055	COG1126	abc transporter atp-binding protein
DIR45_22060	COG0765	amino acid transport
DIR45_22065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DIR45_22085	COG2816	NAD+ diphosphatase activity
DIR45_22090	COG0772	Belongs to the SEDS family
DIR45_22100	COG0508	dehydrogenase complex catalyzes the overall conversion of
DIR45_22105	COG0022	dehydrogenase e1 component
DIR45_22110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DIR45_22115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DIR45_22125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DIR45_22130	COG0280	phosphate acetyltransferase
DIR45_22140	COG3829	transcription factor binding
DIR45_22140	COG3290	protein histidine kinase activity
DIR45_22150	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_22155	COG3093	addiction module antidote protein HigA
DIR45_22165	COG0745	RESPONSE REGULATOR receiver
DIR45_22175	COG0750	zinc metalloprotease
DIR45_22180	COG0497	DNA recombination
DIR45_22190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DIR45_22200	COG0142	geranyltranstransferase activity
DIR45_22225	COG1302	Protein conserved in bacteria
DIR45_22230	COG0439	Biotin carboxylase
DIR45_22235	COG0511	ligase activity, forming carbon-carbon bonds
DIR45_22280	COG3854	ATPases associated with a variety of cellular activities
DIR45_22305	COG0006	proline dipeptidase activity
DIR45_22320	COG3872	metal-dependent enzyme
DIR45_22330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DIR45_22350	COG0095	Lipoate-protein ligase
DIR45_22355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_22360	COG1609	Transcriptional regulator
DIR45_22370	COG2076	Multidrug Resistance protein
DIR45_22375	COG2076	Multidrug Resistance protein
DIR45_22415	COG1131	(ABC) transporter
DIR45_22420	COG1725	Transcriptional regulator
DIR45_22455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_22515	COG4970	Tfp pilus assembly protein FimT
DIR45_22525	COG1459	type II secretion system
DIR45_22530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DIR45_22580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DIR45_22590	COG0646	methionine synthase
DIR45_22590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DIR45_22595	COG0626	cystathionine gamma-synthase activity
DIR45_22600	COG0626	cystathionine gamma-synthase activity
DIR45_22620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_22630	COG1940	carbohydrate kinase activity
DIR45_22635	COG4483	Protein conserved in bacteria
DIR45_22640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DIR45_22650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DIR45_22655	COG0704	Plays a role in the regulation of phosphate uptake
DIR45_22660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DIR45_22665	COG0581	inorganic phosphate transmembrane transporter activity
DIR45_22670	COG0573	inorganic phosphate transmembrane transporter activity
DIR45_22675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DIR45_22685	COG0477	Major facilitator Superfamily
DIR45_22690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_22715	COG0735	belongs to the Fur family
DIR45_22720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DIR45_22725	COG1121	(ABC) transporter
DIR45_22730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_22760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIR45_22765	COG2384	SAM-dependent methyltransferase
DIR45_22770	COG2010	Cytochrome c
DIR45_22775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DIR45_22780	COG0358	DNA primase activity
DIR45_22800	COG0517	IMP dehydrogenase activity
DIR45_22815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DIR45_22820	COG0295	cytidine deaminase activity
DIR45_22825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DIR45_22835	COG1480	7TM receptor with intracellular HD hydrolase
DIR45_22840	COG1702	phosphate starvation-inducible protein PhoH
DIR45_22860	COG1610	YqeY-like protein
DIR45_22875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DIR45_22880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DIR45_22900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DIR45_22910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DIR45_22915	COG1733	regulation of RNA biosynthetic process
DIR45_22940	COG1466	dna polymerase III delta subunit
DIR45_22950	COG2333	competence protein COMEC
DIR45_22950	COG0658	competence protein
DIR45_22955	COG2131	deaminase
DIR45_22960	COG1555	photosystem II stabilization
DIR45_22960	COG1596	polysaccharide export
DIR45_22965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DIR45_22970	COG2226	methyltransferase
DIR45_22975	COG0799	negative regulation of ribosome biogenesis
DIR45_22980	COG1713	HD superfamily hydrolase involved in NAD metabolism
DIR45_22990	COG1534	Rna-binding protein
DIR45_23000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DIR45_23005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DIR45_23020	COG1191	sigma factor activity
DIR45_23030	COG1595	DNA-templated transcription, initiation
DIR45_23040	COG0778	Nitroreductase
DIR45_23045	COG2357	RelA SpoT domain protein
DIR45_23055	COG1785	Belongs to the alkaline phosphatase family
DIR45_23065	COG2267	carboxylic ester hydrolase activity
DIR45_23100	COG1404	Belongs to the peptidase S8 family
DIR45_23105	COG3186	Phenylalanine-4-hydroxylase
DIR45_23115	COG2514	catechol 2,3-dioxygenase activity
DIR45_23120	COG2259	Doxx family
DIR45_23160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_23170	COG1454	alcohol dehydrogenase
DIR45_23170	COG1012	belongs to the aldehyde dehydrogenase family
DIR45_23175	COG0626	cystathionine gamma-synthase activity
DIR45_23180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DIR45_23205	COG0768	penicillin binding
DIR45_23235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DIR45_23255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DIR45_23265	COG0628	permease
DIR45_23285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DIR45_23295	COG0482	sulfurtransferase activity
DIR45_23300	COG1104	cysteine desulfurase activity
DIR45_23305	COG1959	2 iron, 2 sulfur cluster binding
DIR45_23310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DIR45_23320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DIR45_23330	COG0124	histidyl-tRNA synthetase
DIR45_23350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DIR45_23360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DIR45_23360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DIR45_23370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIR45_23370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DIR45_23380	COG2244	polysaccharide biosynthetic process
DIR45_23385	COG2323	membrane
DIR45_23395	COG1862	Preprotein translocase
DIR45_23425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DIR45_23435	COG0697	spore germination
DIR45_23440	COG0697	spore germination
DIR45_23445	COG0640	Transcriptional regulator
DIR45_23470	COG0157	Belongs to the NadC ModD family
DIR45_23475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DIR45_23480	COG1104	cysteine desulfurase activity
DIR45_23485	COG1827	regulation of RNA biosynthetic process
DIR45_23490	COG2258	MOSC domain
DIR45_23495	COG0077	Prephenate dehydratase
DIR45_23500	COG0577	efflux transmembrane transporter activity
DIR45_23505	COG0577	efflux transmembrane transporter activity
DIR45_23510	COG1136	(ABC) transporter
DIR45_23520	COG0745	RESPONSE REGULATOR receiver
DIR45_23525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DIR45_23530	COG3290	protein histidine kinase activity
DIR45_23540	COG2868	ribosomal protein
DIR45_23550	COG1530	ribonuclease E activity
DIR45_23555	COG1994	Peptidase M50
DIR45_23560	COG0739	heme binding
DIR45_23565	COG2894	cell division
DIR45_23580	COG1792	Involved in formation and maintenance of cell shape
DIR45_23585	COG1077	Cell shape determining protein MreB Mrl
DIR45_23610	COG0285	dihydrofolate synthase activity
DIR45_23615	COG0525	valine-tRNA ligase activity
DIR45_23625	COG1388	LysM domain
DIR45_23635	COG0113	porphobilinogen synthase activity
DIR45_23640	COG1587	Uroporphyrinogen-III synthase
DIR45_23650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DIR45_23660	COG1846	Transcriptional regulator
DIR45_23665	COG1764	response to oxidative stress
DIR45_23680	COG1067	ATP-dependent peptidase activity
DIR45_23680	COG0470	DNA polymerase III
DIR45_23735	COG0622	Phosphoesterase
DIR45_23750	COG5401	PFAM Sporulation and spore germination
DIR45_23770	COG1309	transcriptional regulator
DIR45_23785	COG2197	response regulator
DIR45_23790	COG2233	PERMEase
DIR45_23800	COG0402	S-adenosylhomocysteine deaminase activity
DIR45_23805	COG0402	S-adenosylhomocysteine deaminase activity
DIR45_23825	COG0444	Belongs to the ABC transporter superfamily
DIR45_23830	COG4608	Belongs to the ABC transporter superfamily
DIR45_23840	COG3279	Response regulator of the LytR AlgR family
DIR45_23855	COG1983	PspC domain protein
DIR45_23860	COG1396	sequence-specific DNA binding
DIR45_23865	COG0697	spore germination
DIR45_23875	COG1959	2 iron, 2 sulfur cluster binding
DIR45_23880	COG1668	transmembrane transport
DIR45_23885	COG4152	abc transporter atp-binding protein
DIR45_23890	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DIR45_23900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DIR45_23905	COG1876	peptidase activity
DIR45_23910	COG0824	Thioesterase
DIR45_23915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DIR45_23920	COG1053	succinate dehydrogenase
DIR45_23925	COG2009	succinate dehydrogenase
DIR45_23930	COG1719	4-vinyl reductase, 4VR
DIR45_23940	COG3118	belongs to the thioredoxin family
DIR45_23945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DIR45_23950	COG2086	electron transfer activity
DIR45_23955	COG1024	Enoyl-CoA hydratase
DIR45_23960	COG1309	transcriptional regulator
DIR45_23965	COG0318	PFAM AMP-dependent synthetase and ligase
DIR45_23990	COG2318	DinB family
DIR45_24020	COG1131	(ABC) transporter
DIR45_24025	COG2205	protein histidine kinase activity
DIR45_24030	COG0745	RESPONSE REGULATOR receiver
DIR45_24040	COG4895	conserved protein (DUF2196)
DIR45_24045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DIR45_24060	COG4509	Sortase family
DIR45_24065	COG1120	ATPase activity
DIR45_24080	COG5386	Cell surface protein
DIR45_24090	COG5386	Cell surface protein
DIR45_24095	COG1114	Component of the transport system for branched-chain amino acids
DIR45_24100	COG1187	pseudouridine synthase activity
DIR45_24115	COG1796	DNA polymerase
DIR45_24115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DIR45_24120	COG1286	toxin biosynthetic process
DIR45_24150	COG0017	Asparaginyl-tRNA synthetase
DIR45_24155	COG0072	phenylalanine-tRNA ligase activity
DIR45_24155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_24165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DIR45_24175	COG1418	mRNA catabolic process
DIR45_24200	COG2814	Major facilitator Superfamily
DIR45_24205	COG1566	PFAM secretion protein HlyD family protein
DIR45_24210	COG1309	transcriptional regulator
DIR45_24215	COG1363	Peptidase, m42
DIR45_24235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DIR45_24240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DIR45_24250	COG1484	DNA-dependent DNA replication
DIR45_24255	COG3611	Membrane attachment protein
DIR45_24265	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DIR45_24275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIR45_24280	COG0237	dephospho-CoA kinase activity
DIR45_24285	COG1971	Probably functions as a manganese efflux pump
DIR45_24290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DIR45_24295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_24295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DIR45_24300	COG5002	protein histidine kinase activity
DIR45_24305	COG0745	RESPONSE REGULATOR receiver
DIR45_24330	COG0538	isocitrate dehydrogenase activity
DIR45_24335	COG0372	Belongs to the citrate synthase family
DIR45_24350	COG0628	permease
DIR45_24355	COG3030	protein affecting phage T7 exclusion by the F plasmid
DIR45_24380	COG1725	Transcriptional regulator
DIR45_24385	COG0281	malic enzyme
DIR45_24390	COG0587	DNA-directed DNA polymerase activity
DIR45_24405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DIR45_24430	COG4109	DRTGG domain
DIR45_24445	COG0006	proline dipeptidase activity
DIR45_24485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_24490	COG0662	Cupin 2, conserved barrel domain protein
DIR45_24500	COG1476	TRANSCRIPTIONal
DIR45_24515	COG1028	Short-chain dehydrogenase reductase Sdr
DIR45_24520	COG0589	response to stress
DIR45_24570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_24590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DIR45_24595	COG0827	DNA restriction-modification system
DIR45_24600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DIR45_24605	COG3874	Sporulation protein YtfJ
DIR45_24615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DIR45_24620	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DIR45_24630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_24645	COG1104	cysteine desulfurase activity
DIR45_24655	COG0583	DNA-binding transcription factor activity
DIR45_24660	COG0697	spore germination
DIR45_24670	COG1956	GAF domain-containing protein
DIR45_24675	COG0626	cystathionine gamma-synthase activity
DIR45_24700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DIR45_24710	COG1595	DNA-templated transcription, initiation
DIR45_24725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DIR45_24730	COG0454	-acetyltransferase
DIR45_24735	COG0517	IMP dehydrogenase activity
DIR45_24740	COG0123	including yeast histone deacetylase and acetoin utilization protein
DIR45_24750	COG0745	RESPONSE REGULATOR receiver
DIR45_24760	COG0666	response to abiotic stimulus
DIR45_24795	COG1609	Transcriptional regulator
DIR45_24805	COG4851	CamS sex pheromone cAM373 precursor
DIR45_24810	COG3118	belongs to the thioredoxin family
DIR45_24820	COG2309	aminopeptidase activity
DIR45_24840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_24855	COG1674	ftsk spoiiie
DIR45_24865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_24870	COG4848	Belongs to the UPF0354 family
DIR45_24875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_24880	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DIR45_24885	COG1363	Peptidase, m42
DIR45_24895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_24910	COG0510	thiamine kinase activity
DIR45_24915	COG1523	belongs to the glycosyl hydrolase 13 family
DIR45_24930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DIR45_24935	COG1349	DNA-binding transcription factor activity
DIR45_24940	COG1187	pseudouridine synthase activity
DIR45_24945	COG2244	polysaccharide biosynthetic process
DIR45_24950	COG2081	HI0933 family
DIR45_24955	COG2814	Major facilitator Superfamily
DIR45_24965	COG3832	glyoxalase III activity
DIR45_24990	COG1329	Transcriptional regulator
DIR45_25000	COG4975	Glucose uptake
DIR45_25015	COG0314	molybdopterin synthase activity
DIR45_25020	COG1763	Mo-molybdopterin cofactor biosynthetic process
DIR45_25025	COG0303	'Molybdopterin
DIR45_25035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DIR45_25040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DIR45_25060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DIR45_25070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DIR45_25115	COG2814	Major facilitator Superfamily
DIR45_25120	COG0475	glutathione-regulated potassium exporter activity
DIR45_25125	COG0490	domain, Protein
DIR45_25130	COG0582	viral genome integration into host DNA
DIR45_25140	COG1136	(ABC) transporter
DIR45_25160	COG1242	4 iron, 4 sulfur cluster binding
DIR45_25165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DIR45_25175	COG1131	(ABC) transporter
DIR45_25185	COG1794	racemase activity, acting on amino acids and derivatives
DIR45_25210	COG2267	carboxylic ester hydrolase activity
DIR45_25215	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DIR45_25220	COG0671	phosphoesterase, PA-phosphatase related
DIR45_25225	COG0438	transferase activity, transferring glycosyl groups
DIR45_25235	COG0521	Mo-molybdopterin cofactor biosynthetic process
DIR45_25295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DIR45_25300	COG5002	protein histidine kinase activity
DIR45_25305	COG4191	Histidine kinase
DIR45_25310	COG2267	carboxylic ester hydrolase activity
DIR45_25315	COG1368	sulfuric ester hydrolase activity
DIR45_25335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DIR45_25340	COG1116	anion transmembrane transporter activity
DIR45_25345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DIR45_25370	COG0494	nUDIX hydrolase
DIR45_25405	COG0288	reversible hydration of carbon dioxide
DIR45_25410	COG1271	oxidase subunit
DIR45_25415	COG1294	oxidase, subunit
DIR45_25440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_25465	COG1842	Phage shock protein A
DIR45_25500	COG5002	protein histidine kinase activity
DIR45_25505	COG0745	RESPONSE REGULATOR receiver
DIR45_25535	COG1597	lipid kinase activity
DIR45_25570	COG0586	Pfam SNARE associated Golgi protein
DIR45_25580	COG0577	efflux transmembrane transporter activity
DIR45_25585	COG1136	(ABC) transporter
DIR45_25590	COG2207	Transcriptional regulator
DIR45_25590	COG3708	Transcriptional regulator
DIR45_25595	COG0745	RESPONSE REGULATOR receiver
DIR45_25600	COG2205	protein histidine kinase activity
DIR45_25605	COG0577	efflux transmembrane transporter activity
DIR45_25610	COG0577	efflux transmembrane transporter activity
DIR45_25615	COG1136	(ABC) transporter
DIR45_25655	COG3964	amidohydrolase
DIR45_25685	COG4948	Mandelate Racemase Muconate Lactonizing
DIR45_25695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DIR45_25700	COG0596	Alpha beta hydrolase
DIR45_25705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DIR45_25710	COG1169	isochorismate synthase
DIR45_25715	COG1575	Belongs to the MenA family. Type 1 subfamily
DIR45_25720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DIR45_25725	COG1278	Cold shock
DIR45_25745	COG0058	SHG alpha-glucan phosphorylase activity
DIR45_25750	COG0297	glycogen (starch) synthase activity
DIR45_25755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DIR45_25760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DIR45_25785	COG0039	L-malate dehydrogenase activity
DIR45_25885	COG0544	peptidyl-prolyl cis-trans isomerase activity
DIR45_25930	COG1285	pathogenesis
DIR45_25935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DIR45_25945	COG0166	Belongs to the GPI family
DIR45_25955	COG2155	Conserved Protein
DIR45_25960	COG1098	S1 RNA binding domain
DIR45_25965	COG0436	Aminotransferase
DIR45_25970	COG1522	sequence-specific DNA binding
DIR45_25975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DIR45_25980	COG2267	carboxylic ester hydrolase activity
DIR45_25990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DIR45_26005	COG5018	Exonuclease
DIR45_26010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_26030	COG0423	glycine-tRNA ligase activity
DIR45_26035	COG2050	protein possibly involved in aromatic compounds catabolism
DIR45_26045	COG1268	BioY protein
DIR45_26055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIR45_26060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DIR45_26075	COG3584	3D domain protein
DIR45_26090	COG1252	NADH dehydrogenase
DIR45_26105	COG3708	Transcriptional regulator
DIR45_26120	COG1683	Conserved Protein
DIR45_26140	COG0316	Belongs to the HesB IscA family
DIR45_26155	COG1252	NADH dehydrogenase
DIR45_26165	COG2274	protein secretion by the type I secretion system
DIR45_26170	COG0390	transport system, permease component
DIR45_26175	COG2824	Alkylphosphonate utilization operon protein PhnA
DIR45_26215	COG4837	Protein of unknown function (DUF1462)
DIR45_26220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DIR45_26235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DIR45_26240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DIR45_26250	COG2249	NAD(P)H dehydrogenase (quinone) activity
DIR45_26255	COG0647	UMP catabolic process
DIR45_26265	COG2445	Protein of unknown function DUF86
DIR45_26270	COG1494	fructose-1,6-bisphosphatase
DIR45_26290	COG4470	Protein conserved in bacteria
DIR45_26300	COG0789	Transcriptional regulator
DIR45_26305	COG4377	Putative membrane peptidase family (DUF2324)
DIR45_26330	COG0739	heme binding
DIR45_26340	COG3377	Domain of unknown function (DUF1805)
DIR45_26345	COG0737	Belongs to the 5'-nucleotidase family
DIR45_26360	COG1695	Transcriptional regulator
DIR45_26375	COG0719	Fe-S assembly protein
DIR45_26380	COG0822	iron-sulfur transferase activity
DIR45_26385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DIR45_26390	COG0719	Fe-S assembly protein
DIR45_26395	COG0396	ATPase activity
DIR45_26400	COG1464	Belongs to the NlpA lipoprotein family
DIR45_26405	COG1464	Belongs to the NlpA lipoprotein family
DIR45_26410	COG2011	ABC-type metal ion transport system permease component
DIR45_26415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DIR45_26425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DIR45_26430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DIR45_26450	COG1393	Belongs to the ArsC family
DIR45_26505	COG0039	L-malate dehydrogenase activity
DIR45_26530	COG1309	transcriptional regulator
DIR45_26535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DIR45_26540	COG1960	acyl-CoA dehydrogenase activity
DIR45_26550	COG0183	Belongs to the thiolase family
DIR45_26555	COG1024	Enoyl-CoA hydratase
DIR45_26555	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIR45_26570	COG1686	Belongs to the peptidase S11 family
DIR45_26585	COG0011	TIGRFAM Protein of
DIR45_26590	COG0840	transmembrane signaling receptor activity
DIR45_26610	COG2814	Major facilitator Superfamily
DIR45_26615	COG0531	amino acid
DIR45_26625	COG0706	membrane insertase activity
DIR45_26635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DIR45_26675	COG0586	Pfam SNARE associated Golgi protein
DIR45_26685	COG1376	ErfK ybiS ycfS ynhG family protein
DIR45_26690	COG0745	RESPONSE REGULATOR receiver
DIR45_26695	COG5002	protein histidine kinase activity
DIR45_26705	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DIR45_26720	COG2151	metal-sulfur cluster biosynthetic enzyme
DIR45_26725	COG3227	Zinc metalloprotease (Elastase)
DIR45_26730	COG1741	Belongs to the pirin family
DIR45_26745	COG0475	glutathione-regulated potassium exporter activity
DIR45_26750	COG0490	domain, Protein
DIR45_26760	COG1115	amino acid carrier protein
DIR45_26765	COG0783	Belongs to the Dps family
DIR45_26780	COG1611	Belongs to the LOG family
DIR45_26800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_26805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_26810	COG1115	amino acid carrier protein
DIR45_26815	COG1115	amino acid carrier protein
DIR45_26820	COG2910	NAD(P)H-binding
DIR45_26850	COG0656	L-ascorbic acid biosynthetic process
DIR45_26855	COG2814	Major facilitator Superfamily
DIR45_26860	COG1733	regulation of RNA biosynthetic process
DIR45_26870	COG1252	NADH dehydrogenase
DIR45_26875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DIR45_26880	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DIR45_26890	COG3290	protein histidine kinase activity
DIR45_26890	COG0840	transmembrane signaling receptor activity
DIR45_26900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIR45_26905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DIR45_26920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DIR45_26925	COG3223	Belongs to the PsiE family
DIR45_26985	COG0557	exoribonuclease II activity
DIR45_26990	COG1647	Serine aminopeptidase, S33
DIR45_26995	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DIR45_27000	COG1346	cytolysis
DIR45_27110	COG4695	Portal protein
DIR45_27130	COG4974	Belongs to the 'phage' integrase family
DIR45_27145	COG0149	triose-phosphate isomerase activity
DIR45_27155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DIR45_27170	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DIR45_27195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DIR45_27210	COG2323	membrane
DIR45_27215	COG0740	serine-type endopeptidase activity
DIR45_27225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DIR45_27235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DIR45_27245	COG1051	belongs to the nudix hydrolase family
DIR45_27255	COG0492	ferredoxin-NADP+ reductase activity
DIR45_27260	COG0457	Tetratricopeptide repeat
DIR45_27265	COG0110	maltose O-acetyltransferase activity
DIR45_27285	COG1950	PFAM Membrane protein of
DIR45_27295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DIR45_27300	COG0556	nucleotide-excision repair
DIR45_27320	COG0789	Transcriptional regulator
DIR45_27355	COG0583	DNA-binding transcription factor activity
DIR45_27365	COG0655	NAD(P)H dehydrogenase (quinone) activity
DIR45_27380	COG1132	(ABC) transporter
DIR45_27385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_27390	COG0793	Belongs to the peptidase S41A family
DIR45_27390	COG3409	Peptidoglycan-binding domain 1 protein
DIR45_27395	COG2177	Part of the ABC transporter FtsEX involved in
DIR45_27400	COG2884	Cell division ATP-binding protein ftsE
DIR45_27420	COG0653	protein targeting
DIR45_27425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DIR45_27430	COG1278	Cold shock
DIR45_27435	COG1040	competence protein
DIR45_27440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DIR45_27445	COG0791	NLP P60 protein
DIR45_27445	COG1388	LysM domain
DIR45_27450	COG1733	regulation of RNA biosynthetic process
DIR45_27460	COG1307	EDD domain protein, DegV family
DIR45_27465	COG1739	Uncharacterized protein family UPF0029
DIR45_27470	COG1316	TRANSCRIPTIONal
DIR45_27475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DIR45_27480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DIR45_27485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DIR45_27495	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DIR45_27495	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DIR45_27510	COG3394	polysaccharide catabolic process
DIR45_27515	COG1486	melibiose metabolic process
DIR45_27520	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_27525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_27535	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DIR45_27540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DIR45_27545	COG1447	Phosphotransferase system cellobiose-specific component IIA
DIR45_27555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DIR45_27560	COG1301	dicarboxylic acid transport
DIR45_27570	COG0346	lactoylglutathione lyase activity
DIR45_27575	COG1511	domain protein
DIR45_27580	COG0583	DNA-binding transcription factor activity
DIR45_27585	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DIR45_27600	COG1271	oxidase subunit
DIR45_27605	COG1294	oxidase, subunit
DIR45_27610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DIR45_27620	COG1620	l-lactate permease
DIR45_27630	COG2389	metal-binding protein
DIR45_27645	COG1368	sulfuric ester hydrolase activity
DIR45_27665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DIR45_27675	COG1215	transferase activity, transferring glycosyl groups
DIR45_27685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_27695	COG1388	LysM domain
DIR45_27695	COG3584	3D domain protein
DIR45_27720	COG4715	Zinc finger, swim domain protein
DIR45_27725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DIR45_27755	COG1191	sigma factor activity
DIR45_27765	COG0577	efflux transmembrane transporter activity
DIR45_27770	COG1136	(ABC) transporter
DIR45_27805	COG5002	protein histidine kinase activity
DIR45_27810	COG0745	RESPONSE REGULATOR receiver
DIR45_27815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DIR45_27835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DIR45_27840	COG1134	teichoic acid transport
DIR45_27845	COG1682	transport, permease protein
DIR45_27850	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DIR45_27895	COG1609	Transcriptional regulator
DIR45_27910	COG0739	heme binding
DIR45_27930	COG2385	sporulation resulting in formation of a cellular spore
DIR45_27935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DIR45_27945	COG4836	Membrane
DIR45_27955	COG1007	ATP synthesis coupled electron transport
DIR45_27960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIR45_27965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DIR45_27975	COG0839	Belongs to the complex I subunit 6 family
DIR45_27990	COG0649	NAD binding
DIR45_27995	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIR45_28005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DIR45_28010	COG3300	MHYT domain
DIR45_28010	COG5001	Diguanylate cyclase
DIR45_28060	COG0356	it plays a direct role in the translocation of protons across the membrane
DIR45_28095	COG0698	ribose 5-phosphate isomerase
DIR45_28110	COG2190	(PTS) system
DIR45_28115	COG2259	Doxx family
DIR45_28120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DIR45_28140	COG0009	L-threonylcarbamoyladenylate synthase
DIR45_28155	COG2890	protein-(glutamine-N5) methyltransferase activity
DIR45_28160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DIR45_28175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DIR45_28180	COG1494	fructose-1,6-bisphosphatase
DIR45_28190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DIR45_28205	COG4821	SIS domain
DIR45_28215	COG3343	RNA polymerase activity
DIR45_28225	COG1960	acyl-CoA dehydrogenase activity
DIR45_28230	COG1960	acyl-CoA dehydrogenase activity
DIR45_28235	COG1250	3-hydroxyacyl-CoA dehydrogenase
DIR45_28240	COG0183	Belongs to the thiolase family
DIR45_28245	COG2181	nitrate reductase activity
DIR45_28245	COG0247	lactate metabolic process
DIR45_28250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DIR45_28260	COG5001	Diguanylate cyclase
DIR45_28260	COG3300	MHYT domain
DIR45_28280	COG2197	response regulator
DIR45_28285	COG4585	Histidine kinase
DIR45_28290	COG0842	Transport permease protein
DIR45_28295	COG1131	(ABC) transporter
DIR45_28300	COG0024	Methionine aminopeptidase
DIR45_28320	COG2234	aminopeptidase activity
DIR45_28340	COG1595	DNA-templated transcription, initiation
DIR45_28345	COG0018	arginyl-trna synthetase
DIR45_28350	COG4506	Protein conserved in bacteria
DIR45_28355	COG1619	proteins homologs of microcin C7 resistance protein MccF
DIR45_28375	COG0010	Belongs to the arginase family
DIR45_28380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DIR45_28385	COG2814	Major facilitator Superfamily
DIR45_28390	COG0789	Transcriptional regulator
DIR45_28395	COG0584	glycerophosphoryl diester phosphodiesterase
DIR45_28400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DIR45_28415	COG1994	Peptidase M50
DIR45_28425	COG1078	dGTPase activity
DIR45_28430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DIR45_28435	COG1120	ATPase activity
DIR45_28440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_28445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DIR45_28465	COG0095	Lipoate-protein ligase
DIR45_28470	COG0280	phosphate acetyltransferase
DIR45_28485	COG3773	Cell wall hydrolase
DIR45_28495	COG2363	Small membrane protein
DIR45_28505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DIR45_28510	COG2233	PERMEase
DIR45_28515	COG0561	phosphatase activity
DIR45_28520	COG2814	Major facilitator Superfamily
DIR45_28530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DIR45_28535	COG1131	(ABC) transporter
DIR45_28540	COG2755	lipolytic protein G-D-S-L family
DIR45_28545	COG1609	Transcriptional regulator
DIR45_28555	COG0460	homoserine dehydrogenase
DIR45_28575	COG1011	Hydrolase
DIR45_28580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DIR45_28590	COG2197	response regulator
DIR45_28600	COG0351	phosphomethylpyrimidine kinase
DIR45_28605	COG3706	GGDEF domain
DIR45_28610	COG2879	small protein
DIR45_28615	COG1966	Carbon starvation protein
DIR45_28620	COG3279	Response regulator of the LytR AlgR family
DIR45_28625	COG0477	Major facilitator Superfamily
DIR45_28650	COG0840	transmembrane signaling receptor activity
DIR45_28660	COG1607	acyl-coa hydrolase
DIR45_28675	COG0488	(ABC) transporter
DIR45_28705	COG0463	Glycosyl transferase, family 2
DIR45_28710	COG1309	transcriptional regulator
DIR45_28715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DIR45_28720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_28720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DIR45_28725	COG0628	permease
DIR45_28740	COG3279	Response regulator of the LytR AlgR family
DIR45_28745	COG3275	phosphorelay sensor kinase activity
DIR45_28750	COG2814	Major facilitator Superfamily
DIR45_28755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DIR45_28760	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DIR45_28770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DIR45_28790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DIR45_28795	COG1272	protein, Hemolysin III
DIR45_28820	COG1164	Oligoendopeptidase f
DIR45_28840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DIR45_28845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DIR45_28855	COG4863	YycH protein
DIR45_28860	COG5002	protein histidine kinase activity
DIR45_28865	COG0745	RESPONSE REGULATOR receiver
DIR45_28895	COG0305	Participates in initiation and elongation during chromosome replication
DIR45_28905	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DIR45_28910	COG4241	membrane
DIR45_28920	COG0629	single-stranded DNA binding
DIR45_28930	COG0012	GTP binding
DIR45_28935	COG4481	Protein conserved in bacteria
DIR45_28940	COG0668	transmembrane transport
DIR45_28950	COG1475	DNA binding
DIR45_28955	COG1192	Involved in chromosome partitioning
DIR45_28975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DIR45_28980	COG1847	R3H domain protein
DIR45_28985	COG0706	membrane insertase activity
DIR45_29075	COG3344	reverse transcriptase
DIR45_29170	COG3344	reverse transcriptase
DIR45_29265	COG1923	regulation of RNA biosynthetic process
DIR45_29270	COG0457	Tetratricopeptide repeat
DIR45_29295	COG4974	Belongs to the 'phage' integrase family
DIR45_29310	COG3443	Belongs to the bacterial solute-binding protein 9 family
DIR45_29365	COG4974	Belongs to the 'phage' integrase family
DIR45_29560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DIR45_29565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DIR45_29595	COG0671	phosphoesterase, PA-phosphatase related
DIR45_29600	COG4196	transglutaminase domain protein
DIR45_29620	COG2311	Membrane
DIR45_29760	COG4962	Type ii secretion system protein e
DIR45_30035	COG1192	Involved in chromosome partitioning
DIR45_30090	COG1683	Conserved Protein
DIR45_30095	COG1309	transcriptional regulator
DIR45_30175	COG0681	Belongs to the peptidase S26 family
DIR45_30205	COG1280	lysine exporter protein (LysE YggA)
DIR45_30245	COG4166	transmembrane transport
DIR45_30260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII