locus-tag class description DJ48_100 ENOG4105C8J )-transporter DJ48_1003 ENOG4105CZM Major Facilitator DJ48_1004 ENOG4107MII Sugar-specific transcriptional regulator TrmB DJ48_1006 ENOG4108ISG Major Facilitator DJ48_1013 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DJ48_1016 ENOG410874W AraC family transcriptional regulator DJ48_1017 ENOG41082W1 Cupin 2, conserved barrel domain protein DJ48_1020 ENOG4108AEY RNA polymerase sigma factor DJ48_1024 ENOG4108JQ1 Dehydrogenase DJ48_1027 ENOG4105DVH amino acid DJ48_1029 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) DJ48_1032 ENOG4108JPW Aminotransferase DJ48_1034 ENOG4105EJQ L-serine dehydratase DJ48_1035 ENOG4105C44 Serine transporter DJ48_1038 ENOG4108JGH Tetr family transcriptional regulator DJ48_1039 ENOG4105EQ0 Major Facilitator superfamily DJ48_104 ENOG41090VF Stage v sporulation protein ac DJ48_1040 ENOG4105MZU cell filamentation protein DJ48_1043 ENOG4107QJQ Mate efflux family protein DJ48_105 ENOG4105CZ3 stage V sporulation protein ad DJ48_1050 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DJ48_1057 ENOG4105TRI Hydrolase DJ48_1063 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DJ48_1065 ENOG4106P55 Transcriptional regulator DJ48_1067 ENOG4107QR9 Iron-sulfur cluster binding protein DJ48_1068 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DJ48_1069 ENOG4105DJB Major Facilitator Superfamily DJ48_107 ENOG4105G6R Stage v sporulation protein ae DJ48_1070 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DJ48_1072 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DJ48_1073 ENOG4108U05 Transcriptional regulator DJ48_1076 ENOG4105BZU Histidine kinase DJ48_1079 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DJ48_1080 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DJ48_1083 ENOG4105JQZ Methyltransferase DJ48_1084 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DJ48_1086 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase DJ48_1087 ENOG4108NNI Beta-lactamase domain-containing protein DJ48_109 ENOG4105J7I hydrolase DJ48_1090 ENOG4105VZ8 Transcriptional regulator DJ48_1095 ENOG4105K6H D-cysteine desulfhydrase DJ48_11 ENOG4108JUB Transcriptional regulator DJ48_110 ENOG4105PTM secreted protein DJ48_1100 ENOG41062D9 Histidine kinase DJ48_1101 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_1104 ENOG4105IIP Membrane DJ48_1106 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_1107 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DJ48_111 ENOG4107ZE5 PPIases accelerate the folding of proteins DJ48_1120 ENOG4108YXU transcriptional regulator AsnC family DJ48_1121 ENOG4105CHR reductase DJ48_1123 ENOG4105F7F Chaperone DJ48_1127 ENOG41085FC arsR family transcriptional regulator DJ48_1128 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_1129 ENOG4105D6J arsenicaL-resistance protein DJ48_1135 ENOG4105DIK (ABC) transporter DJ48_1136 ENOG4105CC5 ABC transporter DJ48_1137 ENOG4105DSE periplasmic solute binding protein DJ48_1138 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DJ48_1139 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DJ48_1141 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DJ48_1142 ENOG4108TWJ NADH dehydrogenase subunit 5 DJ48_1145 ENOG4105CVP deoxyribo-dipyrimidine photolyase DJ48_1146 ENOG4108606 TspO/MBR family DJ48_1153 ENOG41090MY MarR family Transcriptional regulator DJ48_1158 ENOG4105CHJ isochorismatase hydrolase DJ48_1160 ENOG4105CH6 catalase DJ48_1161 ENOG4105CGH 5'-nucleotidase DJ48_1169 ENOG4105CSV Glutaminase DJ48_1173 ENOG4108Q8B Spore germination protein DJ48_1174 ENOG4108NHD germination protein DJ48_1176 ENOG4105C6K Malic enzyme DJ48_1178 ENOG4105II7 pyrroline-5-carboxylate reductase DJ48_118 ENOG4105CE4 GlcNAc 6-P deacetylase DJ48_1180 ENOG4105CUB amino acid DJ48_1181 ENOG4105CUB amino acid DJ48_1182 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DJ48_1184 ENOG4108IMY Transcriptional regulator DJ48_1185 ENOG4105HDK L-asparaginase DJ48_1186 ENOG4108IJ0 Aspartate ammonia-lyase DJ48_1189 ENOG4105E2A Dehydrogenase DJ48_120 ENOG4105FDP GntR family transcriptional regulator DJ48_1204 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DJ48_1210 ENOG4105DWD nucleoside recognition domain protein DJ48_1214 ENOG4105FDT acyl-CoA dehydrogenase DJ48_1216 ENOG4108ZHR arsR family transcriptional regulator DJ48_1217 ENOG4108ZRV stage ii sporulation protein p DJ48_1218 ENOG4106N3A copper homeostasis protein cutc DJ48_122 ENOG4105CID antiterminator DJ48_1220 ENOG4107258 Transcriptional regulator DJ48_1221 ENOG4105P4J Allophanate hydrolase, subunit 1 DJ48_1228 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DJ48_1231 ENOG4107RF6 penicillin-binding protein DJ48_1239 ENOG4105F1N DNA alkylation repair DJ48_1241 ENOG4108IQI permease DJ48_1242 ENOG4105KNA -acetyltransferase DJ48_1243 ENOG410635A Membrane DJ48_125 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DJ48_1259 ENOG4108XET gCN5-related N-acetyltransferase DJ48_1265 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DJ48_1267 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DJ48_1274 ENOG4105FS7 Transcriptional regulator DJ48_1275 ENOG4108TVJ Nitroreductase DJ48_1277 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DJ48_1286 ENOG4105C8Y Acetylornithine aminotransferase DJ48_1288 ENOG4105CKK Glycosyl transferase, family 2 DJ48_129 ENOG4106TD9 Diguanylate cyclase DJ48_1292 ENOG4105CKK Glycosyl transferase, family 2 DJ48_1297 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DJ48_13 ENOG4107RDP Dehydrogenase DJ48_130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DJ48_1302 ENOG41068WN DJ48_1304 ENOG4108WCX response regulator DJ48_1306 ENOG41090T1 Membrane DJ48_1309 ENOG4105VMP Transcriptional regulator DJ48_131 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DJ48_1311 ENOG4105G6Z alkaline phosphatase DJ48_1312 ENOG4105ECK Fatty Acid Desaturase DJ48_1313 ENOG4105E0Y RtcB Protein DJ48_1315 ENOG4107258 Transcriptional regulator DJ48_1317 ENOG4105II7 pyrroline-5-carboxylate reductase DJ48_1318 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DJ48_1324 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DJ48_1328 ENOG41061GT Aldolase DJ48_1330 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DJ48_1331 ENOG4105DKT Transcriptional regulator DJ48_1333 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DJ48_1335 ENOG4105D4B ABC, transporter DJ48_1341 ENOG4105EMN RNA polymerase sigma factor DJ48_1344 ENOG41069ER domain protein DJ48_1351 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DJ48_1352 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DJ48_1353 ENOG4105CIH Imidazole acetol-phosphate transaminase DJ48_1358 ENOG41082JN Transcriptional regulator DJ48_1359 ENOG4105EYF MMPL domain protein DJ48_1361 ENOG4105C5H ABC transporter DJ48_1362 ENOG4105E0M Sulfatase DJ48_1363 ENOG4108ZCF integral membrane protein DJ48_1365 ENOG4107VMI polysaccharide deacetylase DJ48_1367 ENOG4107VC0 DNA alkylation repair enzyme DJ48_1377 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DJ48_1381 ENOG4105E09 nadh pyrophosphatase DJ48_1387 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DJ48_1388 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DJ48_1389 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DJ48_139 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DJ48_1391 ENOG4105C02 permease DJ48_1399 ENOG4105DVE abc transporter atp-binding protein DJ48_1405 ENOG4105CHM Aminotransferase DJ48_141 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DJ48_1412 ENOG41089UC methyltransferase, type 11 DJ48_1415 ENOG4107BMA Transglycosylase associated protein DJ48_1419 ENOG4106K7D Major facilitator family transporter DJ48_1420 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DJ48_1428 ENOG4105EPR degv family DJ48_143 ENOG4105DTD Dehydrogenase DJ48_1430 ENOG4105DPN Oligoendopeptidase f DJ48_1437 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_1438 ENOG4105BZU Histidine kinase DJ48_1439 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DJ48_144 ENOG4105K7K Transcriptional regulator DJ48_1446 ENOG4105DTQ mandelate racemase muconate lactonizing DJ48_1449 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DJ48_1450 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DJ48_1453 ENOG4107T5V SNARE associated Golgi DJ48_1459 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DJ48_1461 ENOG41080HI glycine oxidase DJ48_1462 ENOG4105CTU Proline racemase DJ48_1463 ENOG4105CTU Proline racemase DJ48_1464 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DJ48_1465 ENOG4105C26 Dehydrogenase DJ48_1466 ENOG4105BZG amino acid carrier protein DJ48_1469 ENOG4108M1A Chitin-binding protein DJ48_1478 ENOG4105C9U ATP-dependent DNA helicase RecQ DJ48_1482 ENOG4105EEM helicase DJ48_1493 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DJ48_1502 ENOG4108M1A Chitin-binding protein DJ48_1503 ENOG41082BV acetyltransferase DJ48_1504 ENOG4105E66 phosphoriboisomerase A DJ48_1509 ENOG4108IJ7 Glycine betaine DJ48_151 ENOG4105CHU acetyl-coa acetyltransferase DJ48_1510 ENOG4107SQ8 Glycine betaine DJ48_1516 ENOG4105RHY Pfam:UPF0157 DJ48_1517 ENOG4105E1F short-chain dehydrogenase reductase DJ48_1519 ENOG4107RUY (E1 component), alpha subunit DJ48_1521 ENOG4107QKR Dehydrogenase DJ48_1526 ENOG41062ES Transcriptional regulator DJ48_1531 ENOG4105E98 transcriptional regulator DeoR family DJ48_1535 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DJ48_1541 ENOG4107Z3H Transcriptional regulator, TetR family DJ48_1542 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DJ48_1543 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DJ48_1544 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) DJ48_1548 ENOG4105MSI germination protein ypeb DJ48_1552 ENOG4108V3A UPF0421 protein DJ48_1559 ENOG4105FDR Membrane DJ48_1561 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DJ48_1566 ENOG4108IUM Glycogen debranching enzyme DJ48_1569 ENOG4105DY8 decarboxylase DJ48_1573 ENOG4105PAD Hydrolase DJ48_1578 ENOG4107VFR oxidoreductase DJ48_1586 ENOG4105PKS Excinuclease abc c subunit domain protein DJ48_1593 ENOG4105KWG Pfam:DUF1696 DJ48_1594 ENOG4108NRW Phospholipase, patatin family DJ48_160 ENOG4105CG3 alpha amylase, catalytic region DJ48_1600 ENOG4108XI2 Domain of unknown function (DUF1963) DJ48_1607 ENOG4108Z4K mutator MutT protein DJ48_1608 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DJ48_1609 ENOG4105E09 nadh pyrophosphatase DJ48_1611 ENOG4105FCD Major Facilitator DJ48_1618 ENOG4107Y9U Membrane DJ48_162 ENOG4107FKK extracellular solute-binding protein family 1 DJ48_1623 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DJ48_1627 ENOG4107Y80 Major Facilitator superfamily DJ48_1632 ENOG4108V4B ThiJ pfpI DJ48_1638 ENOG4105FQP Beta-lactamase DJ48_164 ENOG4105EG2 ABC transporter, permease DJ48_1641 ENOG4105CJN penicillin-binding protein DJ48_1642 ENOG4105CB2 alcohol dehydrogenase DJ48_1645 ENOG4108HGU Histidine kinase DJ48_1648 ENOG4108JJB ABC transporter DJ48_165 ENOG4105FKQ transcriptional regulator DJ48_1652 ENOG4107RF6 penicillin-binding protein DJ48_1653 ENOG4105BZU Histidine kinase DJ48_1655 ENOG410667J hydrolase DJ48_166 ENOG4105CHM Aminotransferase DJ48_1678 ENOG4105ETU transcriptional activator (TenA DJ48_168 ENOG4108HGU Histidine kinase DJ48_1698 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DJ48_17 ENOG4105CPP Dehydrogenase, E1 component DJ48_1701 ENOG4105CPQ Dehydrogenase DJ48_1707 ENOG4105CUV Homoserine Kinase DJ48_1711 ENOG4107Y80 Major Facilitator superfamily DJ48_1713 ENOG4105FQP Beta-lactamase DJ48_1716 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DJ48_1716 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DJ48_1725 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DJ48_1727 ENOG4105T9C HD domain DJ48_1730 ENOG4105DZ1 carboxypeptidase DJ48_1733 ENOG4105DBI uridine monophosphokinase DJ48_1734 ENOG4105WCN acetyltransferase DJ48_1736 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DJ48_1737 ENOG4107QX3 carboxylase DJ48_1738 ENOG4105E39 Enoyl-CoA hydratase DJ48_1739 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DJ48_1740 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DJ48_1741 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DJ48_1742 ENOG4105C1G acyl-Coa dehydrogenase DJ48_1747 ENOG4105CJ1 ABC, transporter DJ48_1750 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DJ48_1751 ENOG4105CEP NADH dehydrogenase DJ48_1752 ENOG4106ANW SMI1_KNR4 DJ48_1754 ENOG4105BZU Histidine kinase DJ48_1756 ENOG4105C5H ABC transporter DJ48_1757 ENOG41067SE Tetr family transcriptional regulator DJ48_1762 ENOG4108VXD carboxy-peptidase DJ48_1765 ENOG4105VZ8 Transcriptional regulator DJ48_1768 ENOG4105CGH 5'-nucleotidase DJ48_1771 ENOG4105DH8 myo-inositol catabolism DJ48_1772 ENOG4105D2N Aldolase DJ48_1777 ENOG4105CK5 oxidoreductase DJ48_1778 ENOG4105IE8 Alpha-ketoglutarate permease DJ48_1779 ENOG4105ETE Transcriptional regulator (LacI family DJ48_1781 ENOG4107RF6 penicillin-binding protein DJ48_1782 ENOG4107RF6 penicillin-binding protein DJ48_1788 ENOG4105CIN aminoacyl-histidine dipeptidase DJ48_179 ENOG4105UIN DJ48_1796 ENOG41090HR transcriptional regulator DJ48_1797 ENOG4107RA9 decarboxylase DJ48_1798 ENOG4108I0C methyltransferase DJ48_18 ENOG4105C7S Dehydrogenase DJ48_1800 ENOG41088CC tellurite resistance protein tehB DJ48_1804 ENOG4108RZE Tetr family transcriptional regulator DJ48_1806 ENOG4105C1J atp-dependent rna helicase DJ48_1809 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DJ48_181 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DJ48_1813 ENOG4107STF Involved in phosphonate degradation (By similarity) DJ48_1815 ENOG4105RD7 BadF BadG BcrA BcrD DJ48_1820 ENOG4105F32 YngK protein DJ48_1825 ENOG4108KPJ rna polymerase sigma factor DJ48_1830 ENOG4108JCI Transcriptional regulator DJ48_1834 ENOG4105BZ1 (ABC) transporter DJ48_1835 ENOG4105BZ1 (ABC) transporter DJ48_1838 ENOG4108RPX mosc domain containing protein DJ48_1839 ENOG4105DND Transcriptional regulator DJ48_184 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DJ48_1842 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DJ48_1843 ENOG4107V2S Transcriptional regulator DJ48_185 ENOG4105EPM Diguanylate phosphodiesterase DJ48_1851 ENOG410667J hydrolase DJ48_1855 ENOG4105VEQ Cold shock protein DJ48_1857 ENOG41068WN DJ48_1859 ENOG4105C1Q protoporphyrinogen oxidase DJ48_1865 ENOG4105WCN acetyltransferase DJ48_1870 ENOG4105EYF MMPL domain protein DJ48_1871 ENOG4105EYF MMPL domain protein DJ48_1873 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DJ48_1876 ENOG41081I9 integral membrane protein DJ48_188 ENOG4107IN1 Protein of unknown function (DUF1797) DJ48_1882 ENOG4108D32 Methyltransferase DJ48_1888 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DJ48_1890 ENOG4105C19 ABC transporter DJ48_1891 ENOG4105C22 threonyL-tRNA synthetase DJ48_1892 ENOG4105FE9 pseudouridine synthase DJ48_1893 ENOG4105FE9 pseudouridine synthase DJ48_1897 ENOG4105BZG amino acid carrier protein DJ48_190 ENOG4108XRC Protein of unknown function (DUF458) DJ48_1901 ENOG4105K70 DNA-binding protein DJ48_1904 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_1905 ENOG4105WQT MbtH domain protein DJ48_1906 ENOG4105CEY Amp-dependent synthetase and ligase DJ48_1907 ENOG4105WQI isochorismatase DJ48_1908 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DJ48_1909 ENOG4105E4F Isochorismate synthase DJ48_1910 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DJ48_1911 ENOG4105FCD Major Facilitator DJ48_1915 ENOG4105EYH Exonuclease DJ48_1916 ENOG4107RFY SbcCD D subunit DJ48_1919 ENOG4105E39 Enoyl-CoA hydratase DJ48_1920 ENOG4105N14 lysine exporter protein LysE YggA DJ48_1922 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DJ48_1923 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DJ48_1924 ENOG4105C1G acyl-Coa dehydrogenase DJ48_1925 ENOG4105CR4 methylisocitrate lyase DJ48_1926 ENOG4105DXD 2-methylcitrate dehydratase DJ48_1928 ENOG4105W8X HesB YadR YfhF-family protein DJ48_1929 ENOG4105CZM Major Facilitator DJ48_1930 ENOG4105BZ4 penicillin-binding protein DJ48_1938 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DJ48_1957 ENOG4108IBT Inherit from COG: transposase DJ48_1959 ENOG4105SZ6 Thioredoxin DJ48_1960 ENOG410841Q phosphoesterase PA-phosphatase related protein DJ48_1962 ENOG4108N23 SpoOM-related protein DJ48_197 ENOG4107ZYR domain protein DJ48_1970 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DJ48_1971 ENOG4108JUB Transcriptional regulator DJ48_1972 ENOG4108TSC N-acetyltransferase DJ48_1973 ENOG4107S4Y M20 DapE family protein YgeY DJ48_1976 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DJ48_198 ENOG4105CN5 Metallo-Beta-Lactamase DJ48_1981 ENOG4105C37 (CBS) domain DJ48_1988 ENOG4105E90 ABC transporter DJ48_1989 ENOG4108IJ8 ABC transporter DJ48_1995 ENOG4105CMG Carbohydrate kinase DJ48_1996 ENOG4105CMG Carbohydrate kinase DJ48_2 ENOG4105DX0 Hemolysin A DJ48_20 ENOG4105E09 nadh pyrophosphatase DJ48_200 ENOG4108X4Q Hydrolase DJ48_2003 ENOG4106KNT transcriptional regulator DJ48_2005 ENOG4105WH1 Two component transcriptional regulator luxr family DJ48_2006 ENOG4105BZU Histidine kinase DJ48_2007 ENOG4105D8X mechanosensitive ion channel DJ48_2008 ENOG4107Y70 Heat shock protein DJ48_201 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DJ48_2014 ENOG4105F0I Aminotransferase DJ48_2015 ENOG4108MES Periplasmic binding protein DJ48_2019 ENOG4105CAQ asparagine synthetase DJ48_2020 ENOG4107Y70 Heat shock protein DJ48_2021 ENOG4108KF3 Electron transport protein SCO1 SenC DJ48_2022 ENOG4105E8R UPF0173 metal-dependent hydrolase DJ48_2023 ENOG4108RCR degv family DJ48_2025 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DJ48_2027 ENOG4108UT2 hemolysin iii DJ48_2028 ENOG4105E9Q Acyl-transferase DJ48_2029 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DJ48_2030 ENOG4107RVG penicillin-binding protein DJ48_2033 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DJ48_2037 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DJ48_204 ENOG4105CPP Dehydrogenase, E1 component DJ48_2042 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DJ48_2044 ENOG4105KD7 acetyltransferase DJ48_2047 ENOG4105C0A alcohol dehydrogenase DJ48_2048 ENOG4105CY2 Citrate transporter DJ48_2049 ENOG4107XGZ Hydrolase DJ48_2053 ENOG4105C8J )-transporter DJ48_2056 ENOG41062D9 Histidine kinase DJ48_2057 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_2058 ENOG4107QPK )-transporter DJ48_2059 ENOG4105BZW Glycerate kinase DJ48_2076 ENOG4105EC2 ftsk spoIIIe DJ48_2080 ENOG4105C5S asparaginyl-tRNA synthetase DJ48_2081 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DJ48_2084 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DJ48_2090 ENOG4105C75 arginyL-tRNA synthetase DJ48_2091 ENOG4107YX5 Pfam:DUF548 DJ48_2095 ENOG41061H0 Monooxygenase DJ48_2098 ENOG4108UUM single-stranded DNA-binding protein DJ48_21 ENOG4105G7B Protein of unknown function (DUF2992) DJ48_2101 ENOG4105C5H ABC transporter DJ48_2105 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DJ48_2108 ENOG4105MCT stage V sporulation protein S DJ48_2115 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DJ48_2116 ENOG4108IFG nitrite reductase, (NAD(P)H) DJ48_2117 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DJ48_2118 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DJ48_2119 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DJ48_2120 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DJ48_2125 ENOG4108ZAF Molybdopterin DJ48_2126 ENOG4105CVM Molybdenum cofactor synthesis domain protein DJ48_2127 ENOG4105D06 uba thif-type nad fad binding protein DJ48_2128 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DJ48_2129 ENOG4107V6Q Cyclic nucleotide-binding domain DJ48_2131 ENOG4105CZV ABC transporter DJ48_2134 ENOG4105R3A Nitrate reductase DJ48_2135 ENOG4108IUE nitrate reductase beta subunit DJ48_2139 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DJ48_214 ENOG4105CXN decarboxylase DJ48_2142 ENOG4108V06 Glutathione peroxidase DJ48_2147 ENOG4105EMN RNA polymerase sigma factor DJ48_2148 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DJ48_2150 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_2151 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DJ48_2155 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DJ48_2160 ENOG4105KBJ sporulation protein ytfj DJ48_2169 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DJ48_2175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DJ48_2176 ENOG4108JYZ YitT family DJ48_2177 ENOG41087PP glycosyltransferase MGT family DJ48_218 ENOG4105ECY inositol monophosphatase DJ48_2180 ENOG4107RBS Methyltransferase DJ48_2181 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DJ48_2183 ENOG4108X4Q Hydrolase DJ48_2188 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DJ48_2190 ENOG4108VXD carboxy-peptidase DJ48_2192 ENOG4108ZRV stage ii sporulation protein p DJ48_2196 ENOG4108Z7R Chaperone CsaA DJ48_220 ENOG4105CI3 gtp-binding protein typa DJ48_2200 ENOG4105C37 (CBS) domain DJ48_2201 ENOG4105SXS Protein of unknown function (DUF456) DJ48_2205 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DJ48_2206 ENOG4108S4H thioesterase Superfamily protein DJ48_2208 ENOG4108PJD permease DJ48_221 ENOG4105QA2 DJ48_2211 ENOG4107T5V SNARE associated Golgi DJ48_2215 ENOG4105CVJ phosphoglycerate mutase DJ48_2220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DJ48_2222 ENOG4105K4T epimerase DJ48_2224 ENOG4105DSE periplasmic solute binding protein DJ48_2236 ENOG4105CKI cobalamin synthesis protein DJ48_2237 ENOG4107QM2 Aldo Keto reductase DJ48_2241 ENOG4105DEN Luciferase family DJ48_2244 ENOG4108WPJ Ferritin-like domain DJ48_2245 ENOG4108K88 Membrane DJ48_2248 ENOG4105C8Q Methyl-accepting chemotaxis DJ48_225 ENOG4108IAB Phoh family DJ48_2253 ENOG4107XZQ multidrug resistance protein DJ48_2254 ENOG4107SET aldo keto reductase DJ48_2255 ENOG4105YVS arsR family transcriptional regulator DJ48_2257 ENOG4105KRN Transcriptional regulator, abrb family DJ48_2267 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DJ48_2269 ENOG4105YWU small acid-soluble spore protein DJ48_2270 ENOG4108WBH protein TIM barrel DJ48_2273 ENOG4105CEY Amp-dependent synthetase and ligase DJ48_2274 ENOG4105DUU IucA IucC family protein DJ48_2276 ENOG4105VRR gCN5-related N-acetyltransferase DJ48_2277 ENOG4105KT7 mgtC SapB transporter DJ48_2279 ENOG4107VMI polysaccharide deacetylase DJ48_228 ENOG4105CNI cell division protein FtsW DJ48_2280 ENOG4105BZU Histidine kinase DJ48_2281 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_2283 ENOG4108KGH TRANSCRIPTIONal DJ48_2288 ENOG4105D6E homoserine dehydrogenase DJ48_229 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DJ48_2292 ENOG4108ZJ4 polysaccharide deacetylase DJ48_2293 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DJ48_2296 ENOG4105BZU Histidine kinase DJ48_2297 ENOG4105EFI regulatoR DJ48_2298 ENOG4105BZ1 (ABC) transporter DJ48_23 ENOG4108HW3 (ABC) transporter DJ48_2306 ENOG4108JJ8 (ABC) transporter DJ48_2307 ENOG4108JJ9 ABC, transporter DJ48_2308 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DJ48_2309 ENOG4105C4M (Ubiquinol oxidase) subunit I DJ48_2311 ENOG4105YGB Transcriptional regulator DJ48_2315 ENOG4105SKE transcriptional Regulator LysR family DJ48_2317 ENOG4105C32 Amino acid ABC transporter (Permease) DJ48_2318 ENOG4108IV0 ABC, transporter DJ48_2319 ENOG4105C0Z ABC transporter DJ48_2321 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DJ48_2322 ENOG4108Z7G MaoC domain protein dehydratase DJ48_2326 ENOG4105CKI cobalamin synthesis protein DJ48_2328 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DJ48_2329 ENOG4106F5Q Membrane DJ48_2330 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DJ48_2333 ENOG4108TVJ Nitroreductase DJ48_2334 ENOG4107ZXU DSBA oxidoreductase DJ48_2335 ENOG4108Z40 Transcriptional regulator DJ48_2336 ENOG4105GZI Transcriptional regulator DJ48_2337 ENOG4107RT3 EamA-like transporter family DJ48_2339 ENOG4105KTB nuclear export factor GLE1 DJ48_2340 ENOG4108T5E Copper resistance protein DJ48_2349 ENOG4107STQ Multicopper oxidase DJ48_2350 ENOG4107RAQ aminopeptidase DJ48_2356 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DJ48_2357 ENOG4105D9N nucleoside DJ48_2359 ENOG4107RHR regulatoR DJ48_2364 ENOG4105C0X amino acid DJ48_2365 ENOG4105C0X amino acid DJ48_2367 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DJ48_2369 ENOG4105C72 UPF0176 protein DJ48_2370 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DJ48_2374 ENOG41068WN DJ48_2380 ENOG4105F6J Alpha beta hydrolase fold DJ48_2384 ENOG4105CYC Transferase DJ48_2385 ENOG4105DY9 regulatoR DJ48_2388 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DJ48_2389 ENOG4105C6X Major Facilitator DJ48_239 ENOG4106UY4 Inherit from COG: Scp-like extracellular DJ48_2393 ENOG4105PNM synthesis protein DJ48_2395 ENOG4105C7B Threonine dehydratase DJ48_2397 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DJ48_2398 ENOG4108ZP8 Acetolactate synthase small subunit DJ48_2399 ENOG4105C7K acetolactate synthase DJ48_24 ENOG4105E5Q amino acid AbC transporter DJ48_2400 ENOG4105CM2 brancheD-chain amino acid aminotransferase DJ48_2401 ENOG4105CHR reductase DJ48_2402 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DJ48_2406 ENOG4106KE4 Dehydrogenase DJ48_2409 ENOG4105H67 Protein of unknown function (DUF421) DJ48_2410 ENOG4105X5K response regulator receiver protein DJ48_2412 ENOG4105C8J )-transporter DJ48_2416 ENOG4105C6T cysteine synthase DJ48_2417 ENOG4105EU0 Major facilitator Superfamily DJ48_2419 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DJ48_242 ENOG4107TB6 phosphoglycerate mutase DJ48_2422 ENOG4105DXI Major Facilitator superfamily DJ48_2423 ENOG4105CSR polyphosphate kinase 2 DJ48_2431 ENOG4105FVX DJ48_2443 ENOG4105C6K Malic enzyme DJ48_2444 ENOG4108IJ0 Aspartate ammonia-lyase DJ48_2446 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DJ48_2450 ENOG4105CJ1 ABC, transporter DJ48_2456 ENOG4106BRA Membrane DJ48_246 ENOG4106H78 methyltransferase DJ48_2463 ENOG4107QIV Cytochrome c biogenesis protein DJ48_2467 ENOG4105EC3 peptidase S51, dipeptidase E DJ48_2468 ENOG4107QJQ Mate efflux family protein DJ48_247 ENOG4105H20 Sporulation integral membrane protein YlbJ DJ48_2472 ENOG4105C9Q fumarate hydratase class II DJ48_2473 ENOG4105C9Q fumarate hydratase class II DJ48_2474 ENOG4105DFD Na H antiporter DJ48_2477 ENOG4108PJD permease DJ48_2478 ENOG4105CKI cobalamin synthesis protein DJ48_2479 ENOG4108UZ3 Transporter DJ48_2480 ENOG4105DRR Transcriptional regulator, GntR family DJ48_2482 ENOG4105PGM cation diffusion facilitator family transporter DJ48_2486 ENOG4105CAQ asparagine synthetase DJ48_2488 ENOG4105K56 Transcriptional regulator DJ48_249 ENOG4105D78 K07001 NTE family protein DJ48_2492 ENOG4105CVJ phosphoglycerate mutase DJ48_2499 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DJ48_25 ENOG4105CDA abc transporter atp-binding protein DJ48_250 ENOG41063PX domain protein DJ48_2500 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DJ48_2501 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DJ48_2502 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DJ48_2503 ENOG4105DUM transcriptional regulator, lysR family DJ48_2509 ENOG4105KAC Antibiotic biosynthesis monooxygenase DJ48_2513 ENOG4108RZE Tetr family transcriptional regulator DJ48_2518 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DJ48_2519 ENOG4105KTQ flagellar basal-body rod protein DJ48_252 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) DJ48_2520 ENOG4105FZW flagellar biosynthesis regulator FlhF DJ48_2521 ENOG4105D7B Flagellar biosynthesis protein flha DJ48_2522 ENOG4105D00 flagellar biosynthetic protein flhB DJ48_2524 ENOG4105VS8 Flagellar biosynthetic protein fliq DJ48_2525 ENOG4105CN7 Flagellar biosynthetic protein FliP DJ48_2527 ENOG4105DD5 Flagellar motor switch protein DJ48_2528 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DJ48_2529 ENOG4105E4C Lytic transglycosylase catalytic DJ48_2531 ENOG4105I03 Flagellin DJ48_2536 ENOG4107TVC Glycosyl transferase, family 2 DJ48_2542 ENOG4105K64 Glycosyl transferase, family 2 DJ48_2544 ENOG4107R88 Chemotaxis protein (CheV) DJ48_2547 ENOG4105BZE flagellar hook protein, FlgE DJ48_2553 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DJ48_2554 ENOG4107U2N Flagellar M-ring protein DJ48_2555 ENOG41075Z6 flagellar hook-basal body complex protein fliE DJ48_2556 ENOG4108ZC9 flagellar basal-body rod protein flgc DJ48_2557 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DJ48_2561 ENOG4105DTJ flagellar hook-associated protein DJ48_2562 ENOG4105E1Q flagellar hook-associated protein DJ48_2566 ENOG4105BZU Histidine kinase DJ48_2569 ENOG4105DD5 Flagellar motor switch protein DJ48_2570 ENOG4105CBS Chea signal transduction histidine kinase DJ48_2571 ENOG4107YTP response regulator receiver protein DJ48_2572 ENOG4105ER2 Ompa motb domain protein DJ48_2573 ENOG4107R0U MotA TolQ exbB proton channel DJ48_2575 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DJ48_2587 ENOG41080C8 DUF218 domain DJ48_2588 ENOG4105H67 Protein of unknown function (DUF421) DJ48_259 ENOG4108IMY Transcriptional regulator DJ48_2590 ENOG4108Z5V transcriptional regulator, merr family DJ48_2591 ENOG4105CN5 Metallo-Beta-Lactamase DJ48_2592 ENOG4107RWR Sodium hydrogen exchanger DJ48_2594 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DJ48_26 ENOG4108QEG Membrane DJ48_2607 ENOG41081VK Ribonuclease DJ48_2611 ENOG4108SZE gCN5-related N-acetyltransferase DJ48_2614 ENOG4105CPK Glycosyl transferase (Group 1 DJ48_2625 ENOG4106032 Glutathionylspermidine synthase DJ48_2628 ENOG4105KHC sulfurtransferase DJ48_2630 ENOG4108W0I acetyltransferase DJ48_2632 ENOG410890F Dynamin family DJ48_2634 ENOG4105DHF Membrane DJ48_2635 ENOG4105C2W permease DJ48_2637 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DJ48_2640 ENOG4105CTD carboxy-peptidase DJ48_2641 ENOG4105DVT helicase DJ48_2643 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DJ48_2654 ENOG4105BZ4 penicillin-binding protein DJ48_2656 ENOG4105CSM endonuclease III DJ48_2660 ENOG4105YAC DJ48_2661 ENOG4105DVT helicase DJ48_2668 ENOG4105CPK Glycosyl transferase (Group 1 DJ48_2669 ENOG4105FJR Lmbe family DJ48_2672 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DJ48_2673 ENOG4108JYZ YitT family DJ48_2679 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DJ48_2680 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DJ48_2681 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DJ48_2684 ENOG41068YB TPR repeat-containing protein DJ48_2685 ENOG4105CIH Imidazole acetol-phosphate transaminase DJ48_2689 ENOG4105EAH synthase DJ48_2691 ENOG4105XXQ heptaprenyl diphosphate synthase component I DJ48_2694 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DJ48_27 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DJ48_270 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_2700 ENOG41065D1 DJ48_2701 ENOG4105S2F DJ48_2708 ENOG4107RB3 L-asparaginase DJ48_2709 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DJ48_2714 ENOG4108S6Z Negative regulator of genetic competence DJ48_2715 ENOG4107X2D transcriptional regulator, merr family DJ48_2716 ENOG4107RGJ metallophosphoesterase DJ48_2718 ENOG4105I7S Abortive infection protein DJ48_2719 ENOG4105C9U ATP-dependent DNA helicase RecQ DJ48_2722 ENOG4108SAX Membrane DJ48_2725 ENOG4108WBT adenosyltransferase DJ48_2726 ENOG4105BZU Histidine kinase DJ48_2727 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_2728 ENOG4105CRE cytochrome C DJ48_2729 ENOG4107TWT Cytochrome c biogenesis protein DJ48_273 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DJ48_2731 ENOG4105FE9 pseudouridine synthase DJ48_2733 ENOG4108JIC nucleoside recognition domain protein DJ48_2734 ENOG4105DZ1 carboxypeptidase DJ48_2735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DJ48_2742 ENOG4105BZU Histidine kinase DJ48_2745 ENOG4105I3N Conserved Protein DJ48_2746 ENOG4105BZU Histidine kinase DJ48_2749 ENOG4105BZ4 penicillin-binding protein DJ48_2750 ENOG4107GRR phosphate transport regulator DJ48_2751 ENOG4105CJ3 phosphate transporter DJ48_2752 ENOG4105CJ3 phosphate transporter DJ48_2756 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DJ48_2761 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DJ48_2765 ENOG4105WH1 Two component transcriptional regulator luxr family DJ48_2766 ENOG4105ENE Histidine kinase DJ48_2770 ENOG4105DFD Na H antiporter DJ48_2774 ENOG4105C8J )-transporter DJ48_2775 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DJ48_2776 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DJ48_2777 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DJ48_2779 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DJ48_2780 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DJ48_2784 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DJ48_2786 ENOG4105E0M Sulfatase DJ48_2787 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DJ48_2790 ENOG4107RVV histidinol phosphate phosphatase, hisj family DJ48_2797 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DJ48_2802 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DJ48_2804 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DJ48_2805 ENOG4108ZP8 Acetolactate synthase small subunit DJ48_2806 ENOG4105C7K acetolactate synthase DJ48_2807 ENOG4105CM2 brancheD-chain amino acid aminotransferase DJ48_2812 ENOG4105KBJ sporulation protein ytfj DJ48_2813 ENOG41063Y9 DJ48_2814 ENOG4105CZN Potassium uptake protein DJ48_2820 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DJ48_2821 ENOG4107QMU Mate efflux family protein DJ48_2828 ENOG4105NQC Flavodoxin DJ48_2833 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DJ48_2835 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DJ48_2836 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DJ48_2837 ENOG4105EA8 2-Nitropropane dioxygenase DJ48_2838 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DJ48_2846 ENOG4105CJ1 ABC, transporter DJ48_2848 ENOG4105CZV ABC transporter DJ48_2849 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DJ48_2850 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DJ48_2851 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DJ48_2853 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DJ48_2854 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DJ48_2862 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DJ48_2863 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DJ48_2865 ENOG4108HGU Histidine kinase DJ48_2866 ENOG4105BZU Histidine kinase DJ48_2868 ENOG4106DF1 DJ48_2870 ENOG41090MY MarR family Transcriptional regulator DJ48_2871 ENOG4105BZU Histidine kinase DJ48_2873 ENOG4105PXI polysaccharide deacetylase DJ48_2875 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DJ48_2879 ENOG4105E98 transcriptional regulator DeoR family DJ48_2882 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DJ48_2883 ENOG4107RCV ABC transporter, permease DJ48_2886 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DJ48_2888 ENOG4105C4Y ABC transporter DJ48_2892 ENOG4105MWK D-amino acid dehydrogenase, small subunit DJ48_2894 ENOG4105CHR reductase DJ48_2898 ENOG4108Z7G MaoC domain protein dehydratase DJ48_2899 ENOG410681C small acid-soluble spore protein DJ48_29 ENOG4105D9U N-acetyltransferase DJ48_290 ENOG4105CAR Terminase, large subunit DJ48_2900 ENOG4105CZN Potassium uptake protein DJ48_2901 ENOG4107TS3 membrane protein, TerC DJ48_2902 ENOG4108QTI )-transporter DJ48_2904 ENOG4106A3R peptidase DJ48_2908 ENOG4105JXH GntR family transcriptional regulator DJ48_2909 ENOG4105BZU Histidine kinase DJ48_2910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_2913 ENOG4105CQB FAD linked oxidase domain protein DJ48_2914 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DJ48_2915 ENOG4105K4I Scp-like extracellular DJ48_2917 ENOG4108YBP pseudouridine synthase DJ48_2919 ENOG4105EYF MMPL domain protein DJ48_292 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DJ48_2921 ENOG4107RUE extracellular solute-binding protein family 1 DJ48_2922 ENOG4105D38 putrescine abc transporter DJ48_2923 ENOG4105F38 ABC transporter, permease DJ48_2924 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DJ48_2925 ENOG4105C26 Dehydrogenase DJ48_2932 ENOG4105VFR signal peptidase DJ48_2933 ENOG4105DZ1 carboxypeptidase DJ48_2935 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DJ48_2946 ENOG4105VZ8 Transcriptional regulator DJ48_2948 ENOG4105C7S Dehydrogenase DJ48_2966 ENOG4105DDQ anthranilate synthase DJ48_2967 ENOG4105DDQ anthranilate synthase DJ48_2968 ENOG4105CRQ synthase (Component I) DJ48_2969 ENOG4105CK7 Sodium proline symporter DJ48_2974 ENOG4108WVJ 2'-5' rna ligase DJ48_2983 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DJ48_2985 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DJ48_2986 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DJ48_2991 ENOG4107TVC Glycosyl transferase, family 2 DJ48_2995 ENOG4105K64 Glycosyl transferase, family 2 DJ48_2999 ENOG4105EMS pseudouridine synthase DJ48_30 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DJ48_3000 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DJ48_3003 ENOG4105MIX Adenylate cyclase DJ48_3004 ENOG4108Z18 K06886 hemoglobin DJ48_3007 ENOG4105DPN Oligoendopeptidase f DJ48_3008 ENOG4105DPN Oligoendopeptidase f DJ48_3010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DJ48_3012 ENOG4108ZCF integral membrane protein DJ48_3016 ENOG4105UQX Mate efflux family protein DJ48_3017 ENOG4108JQ7 (ABC) transporter DJ48_3019 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DJ48_3020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DJ48_3023 ENOG4105C31 Tryptophanyl-tRNA synthetase DJ48_3026 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DJ48_3027 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DJ48_3028 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DJ48_3033 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DJ48_3035 ENOG4108KP7 hydrolase DJ48_3037 ENOG41073B9 DJ48_3038 ENOG4107AYK membrAne DJ48_3040 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DJ48_3042 ENOG4105QNR S1 RNA binding domain protein DJ48_3046 ENOG4105BZU Histidine kinase DJ48_3047 ENOG4105CH6 catalase DJ48_3048 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DJ48_3049 ENOG4105CAQ asparagine synthetase DJ48_3054 ENOG4105ERH Fumarylacetoacetate hydrolase DJ48_3063 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DJ48_3064 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DJ48_3067 ENOG4105XVF Competence transcription factor DJ48_307 ENOG4105XSJ toxin secretion phage lysis holin DJ48_3070 ENOG4105VEQ Cold shock protein DJ48_3073 ENOG4107QP3 malate synthase g DJ48_3074 ENOG4105ZU5 s-layer protein DJ48_3078 ENOG4105C8Q Methyl-accepting chemotaxis DJ48_3079 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DJ48_3084 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_3087 ENOG41086D8 Transcriptional regulator DJ48_3088 ENOG4108AEY RNA polymerase sigma factor DJ48_3090 ENOG4107TVP HD domain protein DJ48_3091 ENOG4107RN3 metallophosphoesterase DJ48_3092 ENOG4105ENX hydrolase DJ48_3097 ENOG4105CNA YD repeat protein DJ48_3103 ENOG4105CEY Amp-dependent synthetase and ligase DJ48_3105 ENOG4105DF9 Lipoate-protein, ligase DJ48_3106 ENOG4108RQ5 Beta-lactamase domain-containing protein DJ48_3107 ENOG4106AXD DJ48_3113 ENOG4105ECB domain protein DJ48_3116 ENOG4105NA0 Transcriptional regulator DJ48_3121 ENOG4105C1Q protoporphyrinogen oxidase DJ48_3123 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DJ48_3124 ENOG4105BZ4 penicillin-binding protein DJ48_3125 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DJ48_3126 ENOG4105CKV Membrane DJ48_3128 ENOG410905X membrane-flanked domain protein DJ48_3136 ENOG4105CKV Membrane DJ48_3137 ENOG410905X membrane-flanked domain protein DJ48_3144 ENOG4105K59 histidine triad (HIT) protein DJ48_3149 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DJ48_3150 ENOG4105EEM helicase DJ48_3152 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_3153 ENOG4105C57 major facilitator superfamily DJ48_3158 ENOG4105EMN RNA polymerase sigma factor DJ48_3161 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DJ48_3164 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DJ48_3168 ENOG4108MUZ hydrolase DJ48_317 ENOG4105KNH Nucleic acid-binding protein DJ48_3173 ENOG4105EQ0 Major Facilitator superfamily DJ48_3174 ENOG4108IND Tetr family transcriptional regulator DJ48_3177 ENOG4105D7V transposase DJ48_3178 ENOG4106D4I domain protein DJ48_3179 ENOG4107VRP DNA repair exonuclease DJ48_3185 ENOG4105K8R UPF0145 protein DJ48_3190 ENOG4105BZU Histidine kinase DJ48_3191 ENOG4105BZU Histidine kinase DJ48_3192 ENOG4108MJI response regulator DJ48_3194 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_3196 ENOG4105WN5 stage II sporulation protein DJ48_32 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DJ48_3209 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DJ48_3214 ENOG410847I Transcriptional regulator, BadM Rrf2 family DJ48_3215 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DJ48_3216 ENOG4105CMT Dihydroxyacetone kinase DJ48_3218 ENOG4105CMT Dihydroxyacetone kinase DJ48_3222 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DJ48_3226 ENOG4108IG5 Transcriptional regulator DJ48_3227 ENOG4107P5I polyketide synthase DJ48_3237 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_324 ENOG41068DC Essential cell division protein (By similarity) DJ48_3245 ENOG4105CDU Replicative dna helicase DJ48_325 ENOG4105CJN penicillin-binding protein DJ48_3254 ENOG4108MRH transcriptional regulatory protein DJ48_3256 ENOG4105CSH Transporter DJ48_326 ENOG4105CJN penicillin-binding protein DJ48_3262 ENOG4108JQ7 (ABC) transporter DJ48_3265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DJ48_327 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DJ48_3273 ENOG4105CTU Proline racemase DJ48_3277 ENOG4105DER m42 family DJ48_3281 ENOG4105CGU Enoyl-CoA hydratase DJ48_3284 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DJ48_3285 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DJ48_3287 ENOG4106AKK s-layer domain-containing protein DJ48_3295 ENOG4105CHH sulfate transporter DJ48_3298 ENOG4105D4P Coproporphyrinogen iii oxidase DJ48_330 ENOG4105CNI cell division protein FtsW DJ48_3300 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DJ48_3306 ENOG4107FQX Alpha-acetolactate decarboxylase DJ48_331 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DJ48_3313 ENOG410839P DJ48_3316 ENOG4105CDA abc transporter atp-binding protein DJ48_3317 ENOG4105DRP amino acid AbC transporter DJ48_3319 ENOG4105BZ1 (ABC) transporter DJ48_332 ENOG4105D4A Cell wall formation (By similarity) DJ48_3320 ENOG4105BZ1 (ABC) transporter DJ48_3321 ENOG4105BZ1 (ABC) transporter DJ48_3322 ENOG4105C26 Dehydrogenase DJ48_3324 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DJ48_3325 ENOG4105D5Q Arginine ornithine antiporter DJ48_3327 ENOG4105CH6 catalase DJ48_3328 ENOG4107RKG DJ-1/PfpI family DJ48_333 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DJ48_3330 ENOG4105E5W Transporter DJ48_3331 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DJ48_3332 ENOG4105NF4 modulator of drug activity DJ48_3337 ENOG4105KPY Small multidrug resistance protein DJ48_3338 ENOG4105KPY Small multidrug resistance protein DJ48_334 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DJ48_3340 ENOG4108YXU transcriptional regulator AsnC family DJ48_3341 ENOG4108PCN EamA-like transporter family DJ48_3348 ENOG4106KNT transcriptional regulator DJ48_335 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DJ48_3350 ENOG4107RWR Sodium hydrogen exchanger DJ48_3351 ENOG4105CUB amino acid DJ48_3358 ENOG4107T5V SNARE associated Golgi DJ48_3365 ENOG4105WEF catalase DJ48_337 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_3371 ENOG4105C19 ABC transporter DJ48_3372 ENOG4107RBB ABC transporter, permease DJ48_3373 ENOG41069ER domain protein DJ48_3377 ENOG4105VZJ PTS System DJ48_3378 ENOG4105VCP PTS System DJ48_3379 ENOG4105EMD TRANSCRIPTIONal DJ48_3384 ENOG4108KGH TRANSCRIPTIONal DJ48_3386 ENOG41087NI Sulfite exporter TauE/SafE DJ48_3387 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DJ48_3389 ENOG41085GJ domain protein DJ48_339 ENOG4105WR5 sporulation protein, YlmC YmxH family DJ48_3391 ENOG4105VFE sira family DJ48_3392 ENOG4107TPS domain protein DJ48_3393 ENOG4105VFE sira family DJ48_3394 ENOG4105XTG Pfam:DUF156 DJ48_3395 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DJ48_340 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DJ48_3400 ENOG4105ED1 spovr family DJ48_3401 ENOG4107Y03 Nitroreductase DJ48_3405 ENOG4108B31 Spore germination protein DJ48_341 ENOG4105DFA alanine racemase domain protein DJ48_3412 ENOG4105C5Y PTS System DJ48_3416 ENOG4108PXI ErfK YbiS YcfS YnhG DJ48_3418 ENOG4105C7N Xanthine uracil vitamin C permease DJ48_3421 ENOG4108INS Transcriptional regulator DJ48_343 ENOG41067XK integral membrane protein DJ48_3430 ENOG4105DWF phosphomethylpyrimidine kinase DJ48_3431 ENOG4105D06 uba thif-type nad fad binding protein DJ48_3434 ENOG41080HI glycine oxidase DJ48_3435 ENOG4108VEU Thiamine monophosphate synthase DJ48_3437 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DJ48_3439 ENOG4105ETU transcriptional activator (TenA DJ48_344 ENOG4105DBK s4 domain protein DJ48_3443 ENOG41080XQ Signal transduction protein with cbs domains DJ48_346 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DJ48_3470 ENOG4105E2Z phosphate ABC transporter (Permease DJ48_3471 ENOG4105C8U phosphate abc transporter DJ48_3472 ENOG4105CVA phosphate DJ48_3473 ENOG4105CE1 Ferrous iron transport protein b DJ48_3474 ENOG4105CE1 Ferrous iron transport protein b DJ48_3475 ENOG4105CE1 Ferrous iron transport protein b DJ48_3476 ENOG4108NHD germination protein DJ48_3479 ENOG4105E1V na solute symporter DJ48_3480 ENOG4106CAD Protein of unknown function (DUF3311) DJ48_3484 ENOG4105E2S oxidase) subunit II DJ48_3485 ENOG4105BZ9 Cytochrome C oxidase, subunit I DJ48_349 ENOG4105C34 Pseudouridine synthase DJ48_3493 ENOG4105C7N Xanthine uracil vitamin C permease DJ48_3494 ENOG4105C85 amino acid DJ48_3499 ENOG4105DUX Transporter DJ48_350 ENOG4105C34 Pseudouridine synthase DJ48_3501 ENOG4107D63 DJ48_3502 ENOG4105VZ8 Transcriptional regulator DJ48_3503 ENOG41069ER domain protein DJ48_3504 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DJ48_3505 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DJ48_3517 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DJ48_3518 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DJ48_3519 ENOG4105CNN ABC, transporter DJ48_3520 ENOG4105C2J ABC transporter DJ48_3522 ENOG4108RVA ribokinase DJ48_3523 ENOG4105ETE Transcriptional regulator (LacI family DJ48_3524 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_3525 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_3526 ENOG41067TZ transcriptional regulator, MarR family DJ48_3527 ENOG4105CXY transporter DJ48_3529 ENOG4108JQ7 (ABC) transporter DJ48_3530 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DJ48_3532 ENOG4105DEF Extracellular solute-binding protein, family 5 DJ48_3534 ENOG41068KF Universal stress protein DJ48_3535 ENOG4105CHH sulfate transporter DJ48_3538 ENOG4105BZU Histidine kinase DJ48_3539 ENOG4105NAE bifunctional deaminase-reductase domain protein DJ48_3540 ENOG4105D29 Helix-turn-helix type 11 domain protein DJ48_3545 ENOG4108IQI permease DJ48_3546 ENOG4105DRP amino acid AbC transporter DJ48_3547 ENOG4105EAD ABC transporter DJ48_3548 ENOG4105CT1 (ABC) transporter DJ48_3549 ENOG4105CDA abc transporter atp-binding protein DJ48_355 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DJ48_3550 ENOG4105BZG amino acid carrier protein DJ48_3551 ENOG4105CRN Aminoglycoside phosphotransferase DJ48_3553 ENOG4105E1K spore germination protein DJ48_3556 ENOG4105CG3 alpha amylase, catalytic region DJ48_3557 ENOG4105C5Y PTS System DJ48_3558 ENOG4107414 GntR family transcriptional regulator DJ48_3559 ENOG4105D5Q Arginine ornithine antiporter DJ48_3560 ENOG4105BZU Histidine kinase DJ48_3563 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DJ48_3564 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DJ48_3565 ENOG4107T89 von Willebrand factor, type A DJ48_3567 ENOG4105EXW epimerase dehydratase DJ48_3569 ENOG4105DMQ Methyltransferase DJ48_3570 ENOG4105E0A ABC, transporter DJ48_3571 ENOG4108IHU transport system permease protein DJ48_3572 ENOG4105DQ5 transport system permease protein DJ48_3573 ENOG4108MES Periplasmic binding protein DJ48_3574 ENOG4105DUX Transporter DJ48_3577 ENOG4105DAA L-lactate DJ48_3578 ENOG4108IJ0 Aspartate ammonia-lyase DJ48_3579 ENOG4108IJ0 Aspartate ammonia-lyase DJ48_3580 ENOG4105C37 (CBS) domain DJ48_3581 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DJ48_3582 ENOG4105D9N nucleoside DJ48_3583 ENOG4108KGH TRANSCRIPTIONal DJ48_3584 ENOG41073R8 VanW family DJ48_3590 ENOG4105DAP Nicotinate phosphoribosyltransferase DJ48_3591 ENOG4105C59 p-type ATPase DJ48_3592 ENOG4105C59 p-type ATPase DJ48_3594 ENOG4105CUB amino acid DJ48_3598 ENOG4108JB9 formate dehydrogenase DJ48_3599 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DJ48_36 ENOG4105EJQ L-serine dehydratase DJ48_3600 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DJ48_3602 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_3603 ENOG4105BZU Histidine kinase DJ48_3605 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DJ48_3606 ENOG4108UZ3 Transporter DJ48_3608 ENOG4105C6K Malic enzyme DJ48_3610 ENOG4108MRH transcriptional regulatory protein DJ48_3615 ENOG4105US7 Histidine kinase DJ48_3616 ENOG4108STX response regulator DJ48_3617 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DJ48_3618 ENOG4105BZ7 extracellular solute-binding protein family 1 DJ48_3619 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DJ48_3620 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DJ48_3621 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DJ48_3622 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DJ48_3626 ENOG4105D4T Citrate transporter DJ48_3627 ENOG4108MRH transcriptional regulatory protein DJ48_3628 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DJ48_3631 ENOG4105DZ6 Band 7 protein DJ48_3634 ENOG4105C94 Transporter DJ48_3638 ENOG4105CYN Serine protein kinase DJ48_3640 ENOG4105BZU Histidine kinase DJ48_3641 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DJ48_3643 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DJ48_3645 ENOG4107ZQN disulfide bond DJ48_3646 ENOG4108JQC penicillin-binding protein 1A DJ48_366 ENOG4105DC7 peptidase M24 DJ48_367 ENOG4105F23 Fibronectin-binding protein DJ48_3671 ENOG4105G5W regulator Fur family DJ48_3672 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DJ48_3676 ENOG4108IUW ABC transporter DJ48_3678 ENOG4105CBC glutamate synthase DJ48_3679 ENOG4107NBY Membrane DJ48_3680 ENOG4105BZ1 (ABC) transporter DJ48_3684 ENOG4106BXE DJ48_3685 ENOG4105CEN a g-specific adenine glycosylase DJ48_3686 ENOG41067AE Membrane-bound metal-dependent hydrolase DJ48_369 ENOG4105DSJ YicC domain protein DJ48_3692 ENOG4105ECP epimerase DJ48_3693 ENOG4105CI2 imidazolone-5-propionate hydrolase DJ48_3697 ENOG4105F1A Pyruvate formate-lyase DJ48_37 ENOG4105II7 pyrroline-5-carboxylate reductase DJ48_3700 ENOG4105C3I Nad-dependent epimerase dehydratase DJ48_3701 ENOG4107QQG Dehydrogenase DJ48_3702 ENOG4107QQG Dehydrogenase DJ48_3703 ENOG4105CKK Glycosyl transferase, family 2 DJ48_3706 ENOG4108A04 Beta-lactamase DJ48_3708 ENOG4105CSV Glutaminase DJ48_3714 ENOG4108IQI permease DJ48_3716 ENOG4108JUB Transcriptional regulator DJ48_3718 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DJ48_373 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DJ48_374 ENOG4105C25 Primosomal protein n' DJ48_375 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DJ48_377 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DJ48_3776 ENOG4105VTR Integrase DJ48_3777 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DJ48_3785 ENOG4105UPD Calcium Proton DJ48_3786 ENOG410606W general stress protein DJ48_3789 ENOG4107ZTW SNARE associated Golgi DJ48_379 ENOG4108ZF3 Phosphatase DJ48_3793 ENOG4108IPJ Membrane DJ48_3794 ENOG4105C59 p-type ATPase DJ48_3795 ENOG4107U9T Pfam:Ribonuclease_BN DJ48_3797 ENOG4105KJF protein tyrosine phosphatase DJ48_38 ENOG41069FQ Metallo-beta-lactamase superfamily DJ48_380 ENOG4105D9P serine threonine protein kinase DJ48_3801 ENOG4108TTB tellurium resistance protein DJ48_3802 ENOG4107TS3 membrane protein, TerC DJ48_3803 ENOG4106FN3 tellurium resistance protein DJ48_3804 ENOG4106FN3 tellurium resistance protein DJ48_3805 ENOG4108N0M stress protein DJ48_3808 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) DJ48_381 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DJ48_3812 ENOG4105DEU major facilitator superfamily DJ48_3816 ENOG41062JF Transcriptional regulator DJ48_382 ENOG4105DJV ribulose-phosphate 3-epimerase DJ48_3821 ENOG4105C5H ABC transporter DJ48_3823 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DJ48_3825 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DJ48_3828 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DJ48_383 ENOG4105FJ0 thiamine DJ48_3834 ENOG4105CI1 PTS System DJ48_3836 ENOG4105C8Q Methyl-accepting chemotaxis DJ48_3837 ENOG4105C8Q Methyl-accepting chemotaxis DJ48_3839 ENOG4105EAB amino acid AbC transporter DJ48_3840 ENOG4105E5Q amino acid AbC transporter DJ48_3843 ENOG4105D2S major facilitator superfamily DJ48_3844 ENOG410756H nucleotidyltransferase DJ48_3848 ENOG4105BZU Histidine kinase DJ48_385 ENOG4108ZAA Alkaline-shock protein DJ48_3852 ENOG4106UIA DJ48_3853 ENOG4106UIA DJ48_3857 ENOG4108V5C ABC transporter DJ48_3858 ENOG4105DQ5 transport system permease protein DJ48_3859 ENOG4105EHG Permease protein DJ48_386 ENOG4105DP4 dak2 domain fusion protein ylov DJ48_3860 ENOG4107W7X Aldolase DJ48_3862 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DJ48_3863 ENOG4105D3R alkyl hydroperoxide reductase DJ48_3868 ENOG4105DFD Na H antiporter DJ48_3869 ENOG4105DTQ mandelate racemase muconate lactonizing DJ48_387 ENOG4105CB5 ATP-dependent DNA helicase recG DJ48_3872 ENOG4108W15 Protein of unknown function (DUF1456) DJ48_3875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DJ48_3876 ENOG4105D9N nucleoside DJ48_3880 ENOG4105KPY Small multidrug resistance protein DJ48_3881 ENOG4105C26 Dehydrogenase DJ48_3883 ENOG4108JPW Aminotransferase DJ48_3884 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DJ48_3885 ENOG4105CBD Diacylglycerol kinase DJ48_3889 ENOG4107I77 yiaA/B two helix domain DJ48_3890 ENOG410834F Transcriptional regulator DJ48_3894 ENOG4105D01 (LipO)protein DJ48_3895 ENOG4108UMI ABC transporter, permease DJ48_3896 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DJ48_3897 ENOG4108W2Y isochorismatase DJ48_39 ENOG4108IXY short-chain dehydrogenase reductase DJ48_390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DJ48_3903 ENOG4105C4R Atp-dependent dna helicase DJ48_3908 ENOG4105C12 Phosphoribosylglycinamide synthetase DJ48_391 ENOG4105CHR reductase DJ48_3910 ENOG4108V3E phosphoribosylglycinamide formyltransferase DJ48_3915 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DJ48_3917 ENOG4105C83 adenylosuccinate lyase DJ48_3918 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DJ48_3919 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DJ48_3924 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_3928 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DJ48_3933 ENOG4108SHN Glycosyl transferase, family 2 DJ48_3938 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DJ48_394 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DJ48_3945 ENOG4105BZU Histidine kinase DJ48_3947 ENOG4105C7N Xanthine uracil vitamin C permease DJ48_395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DJ48_3951 ENOG4108TYN CAAX amino terminal protease family protein DJ48_3954 ENOG4105C5H ABC transporter DJ48_3955 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DJ48_3956 ENOG410801F ribosomal-protein-alanine acetyltransferase DJ48_3957 ENOG41072GX Peptidase M22 Glycoprotease DJ48_3958 ENOG4105K8N protein family UPF0079, ATPase DJ48_3978 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DJ48_3980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DJ48_3981 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DJ48_3984 ENOG4107ZXI Rhomboid family DJ48_3986 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DJ48_3987 ENOG4105CPF Cell wall formation (By similarity) DJ48_3988 ENOG4108SC4 )-transporter DJ48_399 ENOG4105VB6 UPF0109 protein DJ48_3990 ENOG4105ERH Fumarylacetoacetate hydrolase DJ48_3991 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DJ48_3997 ENOG410667J hydrolase DJ48_3998 ENOG4108JQ7 (ABC) transporter DJ48_3999 ENOG4105C3U ABC transporter DJ48_4 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DJ48_4000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DJ48_4002 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DJ48_4005 ENOG4105C5H ABC transporter DJ48_4009 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DJ48_4010 ENOG4108RE7 deoxyribonuclease DJ48_4013 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DJ48_4017 ENOG4105F6E Acyl-transferase DJ48_4024 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DJ48_4025 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DJ48_4026 ENOG4105E0C molybdate abc transporter DJ48_4028 ENOG4107XDY Nicotinamide Mononucleotide Transporter DJ48_4029 ENOG4105II7 pyrroline-5-carboxylate reductase DJ48_4031 ENOG4108J59 Extracellular solute-binding protein, family 5 DJ48_4032 ENOG4108J59 Extracellular solute-binding protein, family 5 DJ48_4038 ENOG4108JQ7 (ABC) transporter DJ48_4039 ENOG4105C3U ABC transporter DJ48_404 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DJ48_4040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DJ48_4041 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DJ48_4044 ENOG4105C2C drug resistance transporter, Bcr CflA DJ48_4047 ENOG4105IQ5 FAD linked oxidase domain protein DJ48_4049 ENOG4105EE1 crotonyl-CoA reductase DJ48_4050 ENOG4105D01 (LipO)protein DJ48_4051 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DJ48_4052 ENOG4108UMI ABC transporter, permease DJ48_4053 ENOG4108PSK reductase DJ48_4059 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DJ48_4060 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DJ48_4062 ENOG4105CMG Carbohydrate kinase DJ48_4064 ENOG4108VQT Alpha beta hydrolase fold protein DJ48_4065 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DJ48_4067 ENOG4107U5W ybbr family DJ48_4068 ENOG4105C8B TIGR00159 family DJ48_407 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DJ48_408 ENOG4105C79 DNA protecting protein DprA DJ48_4086 ENOG4108NMV polysaccharide deacetylase DJ48_4089 ENOG4105D1F ATP-binding protein DJ48_409 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DJ48_4094 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DJ48_4095 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DJ48_4096 ENOG4108JJB ABC transporter DJ48_4102 ENOG41067V7 50S ribosomal protein L36 DJ48_4104 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DJ48_4106 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DJ48_411 ENOG4108HE4 integrase family DJ48_4111 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DJ48_4132 ENOG4105XPM ribosomal protein DJ48_4133 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DJ48_4135 ENOG4107Y49 methyltransferase DJ48_4140 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DJ48_4142 ENOG4105QIV RNA polymerase DJ48_4143 ENOG4105M0M Tetracycline resistance protein DJ48_4144 ENOG4105C2N RNA methyltransferase TrmH family group 3 DJ48_4147 ENOG4105D7W serine acetyltransferase DJ48_4151 ENOG4105CTP PilT protein domain protein DJ48_4153 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DJ48_4156 ENOG4108Z0C Uvrb UvrC protein DJ48_4163 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DJ48_4165 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DJ48_4166 ENOG4105KRF dihydroneopterin aldolase DJ48_4167 ENOG4105EEI dihydropteroate synthase DJ48_4168 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DJ48_4169 ENOG4105DDQ anthranilate synthase DJ48_4170 ENOG4105CRQ synthase (Component I) DJ48_4171 ENOG4105C6T cysteine synthase DJ48_4174 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DJ48_4175 ENOG4108UGV hypoxanthine phosphoribosyltransferase DJ48_4176 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DJ48_4180 ENOG41060GV RNA binding s1 domain protein DJ48_4183 ENOG4105VYY sporulation protein yabp DJ48_4184 ENOG41082I2 s4 domain protein DJ48_4185 ENOG4108IY2 MazG family DJ48_4187 ENOG4108M14 stage v sporulation protein t DJ48_4188 ENOG4108JA2 transcriptioN-repair coupling factor DJ48_4190 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DJ48_4191 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DJ48_4194 ENOG4105KME endoribonuclease L-psp DJ48_4195 ENOG4105DFT pur operon repressor DJ48_4198 ENOG4105W42 Veg protein DJ48_4199 ENOG4105XFA sporulation peptidase YabG DJ48_42 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DJ48_420 ENOG4105KNE Phosphatidate cytidylyltransferase DJ48_4201 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DJ48_4202 ENOG4105F8V Hydrolase, tatD family DJ48_4204 ENOG4105KRN Transcriptional regulator, abrb family DJ48_4205 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DJ48_4207 ENOG41060K3 Methyltransferase DJ48_4209 ENOG4105MA4 psp1 domain protein DJ48_421 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DJ48_4210 ENOG4105FA2 dna polymerase iii DJ48_4212 ENOG4105CXN decarboxylase DJ48_4219 ENOG41067KS pro-sigma K processing DJ48_422 ENOG4105DZP Membrane-associated zinc metalloprotease DJ48_4223 ENOG4105C6E dna polymerase iii DJ48_4224 ENOG4108Z6B deaminase DJ48_4225 ENOG4105GTG Isochorismatase DJ48_4227 ENOG4105ZMH deoxynucleoside kinase DJ48_4234 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DJ48_424 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DJ48_4242 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DJ48_4245 ENOG410848D S4 domain protein YaaA DJ48_4246 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DJ48_4250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DJ48_4252 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DJ48_4256 ENOG4107QJE Chromosome Partitioning Protein DJ48_4257 ENOG4105FA0 parb-like partition protein DJ48_4258 ENOG4108ZDA Sporulation protein YyaC DJ48_4259 ENOG4105D8X mechanosensitive ion channel DJ48_426 ENOG4105CHV Transcription elongation factor NusA DJ48_4260 ENOG4105VDK protein, conserved in bacteria DJ48_4261 ENOG4105C3G gtp-binding protein DJ48_4263 ENOG4108UUM single-stranded DNA-binding protein DJ48_4265 ENOG4108XMW Membrane DJ48_4266 ENOG4105BZR domain protein DJ48_4268 ENOG4105CDU Replicative dna helicase DJ48_427 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DJ48_4274 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_4275 ENOG4105BZU Histidine kinase DJ48_4278 ENOG4105Q2H domain protein DJ48_4279 ENOG4105C0H protease DJ48_428 ENOG4105VHM ribosomal protein DJ48_4283 ENOG4105DPN Oligoendopeptidase f DJ48_4286 ENOG4105C1J atp-dependent rna helicase DJ48_4288 ENOG4108UT2 hemolysin iii DJ48_4289 ENOG4105CMR udp-glucose 4-epimerase DJ48_4291 ENOG4105IW1 AmiS UreI transporter DJ48_4293 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DJ48_4296 ENOG4107RGD Major Facilitator superfamily DJ48_4297 ENOG4108HRK Histidine kinase DJ48_4298 ENOG4105DY9 regulatoR DJ48_430 ENOG4105W7A Protein of unknown function (DUF503) DJ48_4301 ENOG4106F5Q Membrane DJ48_4302 ENOG4105E0X reductase DJ48_4304 ENOG41067SE Tetr family transcriptional regulator DJ48_4305 ENOG4105CKK Glycosyl transferase, family 2 DJ48_4310 ENOG4105C5H ABC transporter DJ48_4311 ENOG4105JEU Glycosyl transferase, family 2 DJ48_4313 ENOG4108S4H thioesterase Superfamily protein DJ48_4315 ENOG4106YBV Methyl-accepting chemotaxis DJ48_4316 ENOG4105EN6 Membrane DJ48_432 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DJ48_4320 ENOG41079KZ Major Facilitator Superfamily DJ48_4321 ENOG4105DY9 regulatoR DJ48_4322 ENOG4105D22 carbon starvation protein DJ48_4323 ENOG4105VCD cytoplasmic protein DJ48_4324 ENOG4105BZU Histidine kinase DJ48_4325 ENOG4105DWF phosphomethylpyrimidine kinase DJ48_4326 ENOG4105BZU Histidine kinase DJ48_4327 ENOG4105BZU Histidine kinase DJ48_4328 ENOG4105WH1 Two component transcriptional regulator luxr family DJ48_433 ENOG4105DTN riboflavin biosynthesis protein ribF DJ48_4330 ENOG4108Y4K DNA-binding transcriptional activator DJ48_4335 ENOG4105D6E homoserine dehydrogenase DJ48_4338 ENOG41090WU lipolytic protein G-D-S-L family DJ48_4339 ENOG4105CJ1 ABC, transporter DJ48_4340 ENOG4108TU7 Inherit from COG: (ABC) transporter DJ48_4342 ENOG4105VCH membrane DJ48_4343 ENOG410667J hydrolase DJ48_4345 ENOG4107SVH Potassium channel protein DJ48_4349 ENOG4108VKI Cell wall hydrolase DJ48_4352 ENOG4108IJ2 phosphate acetyltransferase DJ48_4355 ENOG4108VCI transcription factor, rsfa family DJ48_4357 ENOG4105DQ5 transport system permease protein DJ48_4358 ENOG4105EHG Permease protein DJ48_4359 ENOG4105E0A ABC, transporter DJ48_4360 ENOG4108MES Periplasmic binding protein DJ48_4361 ENOG4105DCI Phosphohydrolase DJ48_4362 ENOG41069HH 4-oxalocrotonate tautomerase DJ48_4363 ENOG4108Z4T Peptidase M50 DJ48_4364 ENOG4108XFG YwhD family DJ48_4365 ENOG4105BZ4 penicillin-binding protein DJ48_4366 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DJ48_4367 ENOG4107SWG transcriptional regulator MERR family DJ48_4368 ENOG4105DXB Major Facilitator superfamily DJ48_437 ENOG4105C1V Peptidase, M16 DJ48_4370 ENOG4105CYW agmatinase DJ48_4374 ENOG410684U Domain of unknown function (DUF1934) DJ48_4376 ENOG4105EMN RNA polymerase sigma factor DJ48_4380 ENOG4105IIU Aminopeptidase DJ48_4383 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DJ48_4384 ENOG4108M15 ABC transporter DJ48_4385 ENOG4105KCT ABC transporter DJ48_4386 ENOG4105BZU Histidine kinase DJ48_439 ENOG4105E35 Dipicolinate synthase subunit A DJ48_4391 ENOG4105BZU Histidine kinase DJ48_4394 ENOG4105DF6 Fe-S oxidoreductase DJ48_4396 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DJ48_4397 ENOG4105C1G acyl-Coa dehydrogenase DJ48_4398 ENOG4105C1G acyl-Coa dehydrogenase DJ48_440 ENOG4108S0H Dipicolinic acid synthetase, b subunit DJ48_4406 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DJ48_4407 ENOG4105CBT Fructose-1,6-bisphosphatase DJ48_4408 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DJ48_441 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DJ48_4411 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DJ48_4412 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DJ48_4413 ENOG4108ZXQ stage ii sporulation protein r DJ48_4415 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DJ48_4418 ENOG4107XC4 flavin reductase domain protein, FMN-binding DJ48_4419 ENOG4108VGI doxx family DJ48_4422 ENOG4108YZG isomerase DJ48_4427 ENOG41062M3 atp synthase DJ48_4428 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DJ48_443 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DJ48_4438 ENOG4105BZU Histidine kinase DJ48_4439 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DJ48_4441 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DJ48_4442 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DJ48_4447 ENOG4105D65 subunit l DJ48_4448 ENOG4105C8S subunit m DJ48_4449 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DJ48_445 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DJ48_4450 ENOG4106778 Protein of unknown function (DUF1146) DJ48_4454 ENOG4105DY9 regulatoR DJ48_4457 ENOG4105FRN stage II sporulation protein DJ48_4459 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DJ48_4469 ENOG4105EY8 ABC transporter DJ48_447 ENOG4107QZI cell division protein FtsK DJ48_4470 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DJ48_4474 ENOG4105CMR udp-glucose 4-epimerase DJ48_4475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_4476 ENOG4105BZU Histidine kinase DJ48_4479 ENOG4105CXY transporter DJ48_448 ENOG4105FDP GntR family transcriptional regulator DJ48_4483 ENOG4105C19 ABC transporter DJ48_4484 ENOG4107RBB ABC transporter, permease DJ48_4486 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_449 ENOG4105DIH basic membrane DJ48_4492 ENOG4105C0D helicase DJ48_4493 ENOG4105KBK Zinc finger, swim domain protein DJ48_4498 ENOG41069ER domain protein DJ48_4499 ENOG4105C94 Transporter DJ48_450 ENOG4108JQ9 ABC transporter DJ48_4501 ENOG4107R8N Glycosyl transferase, family 2 DJ48_4507 ENOG4105E0M Sulfatase DJ48_451 ENOG4105UIB (ABC) transporter DJ48_4510 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DJ48_4512 ENOG4105DAA L-lactate DJ48_452 ENOG4105UIB (ABC) transporter DJ48_4521 ENOG4107RSM transcriptional regulator DJ48_4522 ENOG4105ECB domain protein DJ48_4523 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_4526 ENOG4105VZJ PTS System DJ48_4528 ENOG4105VCP PTS System DJ48_4529 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DJ48_4530 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DJ48_4532 ENOG4105CK1 PTS System DJ48_4533 ENOG4105VCP PTS System DJ48_4534 ENOG4105F8D glycoside hydrolase family 4 DJ48_4535 ENOG410901P UPF0249 protein DJ48_4538 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DJ48_4540 ENOG4105ESV Glycosyl transferase, family 4 DJ48_4541 ENOG4105C6Y Udp-glucose 6-dehydrogenase DJ48_4542 ENOG4105C6Y Udp-glucose 6-dehydrogenase DJ48_4543 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DJ48_4544 ENOG4108KGH TRANSCRIPTIONal DJ48_4545 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DJ48_4547 ENOG4105KVH Transcriptional regulator DJ48_4550 ENOG41081UC Inherit from COG: Competence protein DJ48_4551 ENOG4105VEQ Cold shock protein DJ48_4552 ENOG4105MS2 ribosomal subunit Interface protein DJ48_4553 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DJ48_4554 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DJ48_4556 ENOG4105CAK Cell division ATP-binding protein ftsE DJ48_4557 ENOG4105CRP Part of the ABC transporter FtsEX involved in DJ48_4558 ENOG4105CN1 protease DJ48_456 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DJ48_4560 ENOG4105BZ1 (ABC) transporter DJ48_4563 ENOG4108WS4 fmn reductase DJ48_4565 ENOG4105DUM transcriptional regulator, lysR family DJ48_4566 ENOG4105HMI Membrane DJ48_457 ENOG4105XZV Protein of unknown function (DUF3243) DJ48_4571 ENOG4107TXC Transcriptional regulator DJ48_4574 ENOG4105D7V transposase DJ48_4575 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DJ48_4576 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DJ48_4577 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DJ48_4579 ENOG41086DT Membrane protein of unknown function DJ48_4583 ENOG4108S4C acetyltransferase DJ48_4585 ENOG4105C3M thioredoxin reductase DJ48_4587 ENOG4108Z4K mutator MutT protein DJ48_4589 ENOG4105CHW UPF0052 protein DJ48_4591 ENOG4105KRI phosphocarrier protein (HPr DJ48_4592 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DJ48_4593 ENOG4105H67 Protein of unknown function (DUF421) DJ48_4596 ENOG4105CZ3 stage V sporulation protein ad DJ48_4597 ENOG41090VF Stage v sporulation protein ac DJ48_460 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DJ48_4601 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_4606 ENOG4105CP7 Triose-phosphate isomerase DJ48_4607 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DJ48_4609 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DJ48_4613 ENOG4105EFC phage portal protein HK97 family DJ48_4632 ENOG41067MG lrgb family DJ48_4633 ENOG4105XZU Preprotein translocase, subunit SecG DJ48_4635 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DJ48_4640 ENOG4105CM4 permease protein DJ48_4641 ENOG4108IPW abc transporter atp-binding protein DJ48_4644 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DJ48_4645 ENOG4108MK9 spermidine N(1)-acetyltransferase DJ48_4648 ENOG4105WMR Protein CrcB homolog DJ48_4649 ENOG4105WMR Protein CrcB homolog DJ48_465 ENOG4105D48 metallophosphoesterase DJ48_4651 ENOG4105C8Q Methyl-accepting chemotaxis DJ48_4653 ENOG4105D4A Cell wall formation (By similarity) DJ48_4654 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DJ48_4657 ENOG4105KVH Transcriptional regulator DJ48_4658 ENOG4105F27 Major Facilitator DJ48_4659 ENOG4105CV8 reductase DJ48_466 ENOG4105MCT stage V sporulation protein S DJ48_4663 ENOG4108RYK Nad-dependent epimerase dehydratase DJ48_4666 ENOG4105D9N nucleoside DJ48_4667 ENOG4105D9N nucleoside DJ48_467 ENOG4108IGT Dipeptidase DJ48_4672 ENOG4108URH decarboxylase DJ48_4675 ENOG4108RMU ferritin dps family protein DJ48_4677 ENOG4105NCW Trka-c domain protein DJ48_4678 ENOG4107S91 Sodium hydrogen exchanger DJ48_468 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DJ48_4682 ENOG4105D4Y metalloprotease DJ48_4683 ENOG4105VG1 fes assembly suf system protein DJ48_4686 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DJ48_4688 ENOG4105BZU Histidine kinase DJ48_4689 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_469 ENOG4105DQU oxidoreductase, subunit beta DJ48_4690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DJ48_4692 ENOG4107ZTW SNARE associated Golgi DJ48_4699 ENOG4107AYK membrAne DJ48_470 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DJ48_4701 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DJ48_4703 ENOG4107R7I amino acid DJ48_4704 ENOG4108SUT Major Facilitator Superfamily DJ48_4708 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DJ48_4712 ENOG4105DZ1 carboxypeptidase DJ48_4715 ENOG4105CHU acetyl-coa acetyltransferase DJ48_4716 ENOG4105C1G acyl-Coa dehydrogenase DJ48_4717 ENOG4108W8B Beta-lactamase domain protein DJ48_4723 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DJ48_4732 ENOG41080E8 Transcriptional regulator, Spx MgsR family DJ48_4738 ENOG4108UMI ABC transporter, permease DJ48_4739 ENOG4105D01 (LipO)protein DJ48_4740 ENOG4105D01 (LipO)protein DJ48_4741 ENOG4105C3K feS assembly ATPase SufC DJ48_4742 ENOG4105JRK feS assembly protein SufD DJ48_4743 ENOG4105C9B Cysteine desulfurase DJ48_4744 ENOG4108UNV SUF system FeS assembly protein, NifU family DJ48_4745 ENOG4105DIW FeS assembly protein SUFB DJ48_4748 ENOG4107R8B 5'-nucleotidase DJ48_4749 ENOG4105KZD Domain of unknown function (DUF1805) DJ48_475 ENOG4105DA5 (ABC) transporter DJ48_4751 ENOG4105FAA peptidase M23 DJ48_4756 ENOG41090T1 Membrane DJ48_4757 ENOG4107TXC Transcriptional regulator DJ48_4758 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DJ48_4759 ENOG4105MMD transcriptional regulator DJ48_4762 ENOG4105CBT Fructose-1,6-bisphosphatase DJ48_4765 ENOG4105D4U had-superfamily hydrolase, subfamily iia DJ48_4766 ENOG4105DYS nad(p)h dehydrogenase (quinone) DJ48_4768 ENOG4108W5N phosphatidylglycerophosphatase a DJ48_4771 ENOG41083MR nifu domain-containing protein DJ48_4780 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DJ48_4781 ENOG4105C4B ABC transporter, permease DJ48_4782 ENOG4108JJA ABC, transporter DJ48_4786 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DJ48_4789 ENOG4105EWC Purine nucleoside phosphorylase DJ48_4796 ENOG4105CEP NADH dehydrogenase DJ48_4799 ENOG41069ER domain protein DJ48_480 ENOG4107QHE Choloylglycine hydrolase DJ48_4803 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DJ48_4807 ENOG4105KA0 thioesterase Superfamily protein DJ48_4808 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DJ48_4811 ENOG4107R3E Citrate transporter DJ48_4813 ENOG4105Y38 Kinase-associated protein B DJ48_4816 ENOG4105C87 Aminotransferase class I and II DJ48_4818 ENOG4108MUZ hydrolase DJ48_4819 ENOG4105C5I Dehydrogenase DJ48_482 ENOG410890F Dynamin family DJ48_4820 ENOG4108ZB6 transcriptional regulator AsnC family DJ48_4821 ENOG4105CHM Aminotransferase DJ48_4823 ENOG4105WG9 Conserved Protein DJ48_4824 ENOG4107QYV phosphohexose isomerase DJ48_4825 ENOG4107PBV potassium channel DJ48_4827 ENOG4105KT7 mgtC SapB transporter DJ48_483 ENOG4105E0M Sulfatase DJ48_4835 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DJ48_484 ENOG4107R6R udp-galactopyranose mutase DJ48_485 ENOG4105F0V Cell wall hydrolase DJ48_4854 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DJ48_4856 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DJ48_4858 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DJ48_4863 ENOG4105VEQ Cold shock protein DJ48_4865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DJ48_4866 ENOG4105E4F Isochorismate synthase DJ48_4867 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DJ48_4868 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DJ48_4869 ENOG4108IPT Naphthoate synthase DJ48_4871 ENOG4105DTQ mandelate racemase muconate lactonizing DJ48_4878 ENOG41069H0 dihydroorotase EC 3.5.2.3 DJ48_488 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DJ48_4882 ENOG4105FDP GntR family transcriptional regulator DJ48_4883 ENOG4105C6Z Gluconate DJ48_4891 ENOG41086D8 Transcriptional regulator DJ48_4892 ENOG4105C19 ABC transporter DJ48_4895 ENOG4107ZTW SNARE associated Golgi DJ48_490 ENOG4107YEI lmbE family DJ48_4902 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DJ48_4903 ENOG4108UGV hypoxanthine phosphoribosyltransferase DJ48_4908 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_4909 ENOG4105BZU Histidine kinase DJ48_491 ENOG4107TTQ Alpha beta hydrolase fold DJ48_4916 ENOG41087YS Phage shock protein A DJ48_4925 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DJ48_4926 ENOG4105C4M (Ubiquinol oxidase) subunit I DJ48_4928 ENOG4108V2W Carbonate dehydratase DJ48_4935 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DJ48_4939 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DJ48_494 ENOG41067MG lrgb family DJ48_4941 ENOG4105D2X ABC transporter substrate-binding protein DJ48_4944 ENOG4107T7U Sulfatase DJ48_4945 ENOG4107S9D Alpha beta hydrolase DJ48_4946 ENOG4105BZU Histidine kinase DJ48_4947 ENOG4105BZU Histidine kinase DJ48_4948 ENOG4105EGD dinuclear metal center protein, YbgI family DJ48_4958 ENOG4108RIR Molybdenum cofactor biosynthesis protein DJ48_4960 ENOG4105BZF Glycosyl transferase (Group 1 DJ48_4961 ENOG4105YVM Phosphoesterase, PA-phosphatase related DJ48_4962 ENOG4108Z0R Transferase DJ48_4963 ENOG4105E8V Alpha Beta Hydrolase Fold protein DJ48_4969 ENOG4105DA5 (ABC) transporter DJ48_497 ENOG4105BZU Histidine kinase DJ48_4971 ENOG4105N5T Radical SAM Protein DJ48_4975 ENOG4105C19 ABC transporter DJ48_4978 ENOG4105NCW Trka-c domain protein DJ48_4979 ENOG4107S91 Sodium hydrogen exchanger DJ48_498 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_4980 ENOG410605W Major Facilitator DJ48_4986 ENOG4108B31 Spore germination protein DJ48_4988 ENOG4105DWV Homoserine O-trans-acetylase DJ48_4990 ENOG41085GJ domain protein DJ48_4994 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DJ48_4995 ENOG4105D06 uba thif-type nad fad binding protein DJ48_4997 ENOG4105CVM Molybdenum cofactor synthesis domain protein DJ48_4998 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DJ48_4999 ENOG4108ZAF Molybdopterin DJ48_5 ENOG4105S1Z Stage IV sporulation protein B DJ48_50 ENOG4105CGH 5'-nucleotidase DJ48_5003 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DJ48_5004 ENOG4108VJ1 Transcriptional regulator (CarD family DJ48_5013 ENOG4105CBX hi0933 family DJ48_5016 ENOG4105YW5 deoR family transcriptional regulator DJ48_5017 ENOG4107QSE Dipeptidase DJ48_5019 ENOG4108IUM Glycogen debranching enzyme DJ48_5020 ENOG4108V15 phosphotransferase enzyme family DJ48_5023 ENOG4105C8F Beta-lactamase domain protein DJ48_5029 ENOG4108VDD TRNA binding domain protein DJ48_5038 ENOG4105C88 aminopeptidase DJ48_504 ENOG4105D03 DNA-3-methyladenine glycosylase II DJ48_5042 ENOG4105ETE Transcriptional regulator (LacI family DJ48_5043 ENOG4105ETE Transcriptional regulator (LacI family DJ48_5049 ENOG4105EP9 oxidoreductase DJ48_505 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DJ48_5050 ENOG4107SNB ankyrin repeat protein YahD DJ48_5052 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_5054 ENOG4105DGU Histone deacetylase DJ48_5055 ENOG4105W87 Cbs domain DJ48_5056 ENOG4105F1V Acetoin utilization protein DJ48_5059 ENOG4105EMN RNA polymerase sigma factor DJ48_5061 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DJ48_5065 ENOG4105C28 cystathionine DJ48_5067 ENOG4105U5Y Transcriptional regulator DJ48_5069 ENOG4106KR7 LysR family Transcriptional regulator DJ48_507 ENOG4105CGK Exodeoxyribonuclease III DJ48_5074 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DJ48_5076 ENOG4105EFZ amidohydrolase DJ48_5079 ENOG4105KBJ sporulation protein ytfj DJ48_5080 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DJ48_5082 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DJ48_5086 ENOG4108JYZ YitT family DJ48_5095 ENOG4107YZX Universal stress protein DJ48_5099 ENOG4105VZ8 Transcriptional regulator DJ48_51 ENOG4105DFD Na H antiporter DJ48_5101 ENOG41082W1 Cupin 2, conserved barrel domain protein DJ48_5102 ENOG4105Z7P Acetyltransferase (GNAT) family DJ48_5109 ENOG4105DC7 peptidase M24 DJ48_5116 ENOG4105SFS phosphoesterase RecJ domain protein DJ48_5118 ENOG4105VV2 DJ48_5119 ENOG4105C0B DNA polymerase III (alpha subunit) DJ48_512 ENOG4105E0A ABC, transporter DJ48_5120 ENOG4105C6K Malic enzyme DJ48_5121 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DJ48_5126 ENOG4105FS0 cytoplasmic membrane protein DJ48_5127 ENOG4108REF Sporulation integral membrane protein ytvi DJ48_5129 ENOG4105BZN citrate synthase DJ48_513 ENOG4105NIV Esterase DJ48_5130 ENOG4108HMX isocitrate dehydrogenase (NADP) DJ48_5134 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_5135 ENOG4105BZU Histidine kinase DJ48_5136 ENOG4105C2M dna polymerase I DJ48_5137 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DJ48_5139 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DJ48_5140 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DJ48_5141 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DJ48_5145 ENOG4108TDW sporulation protein YtxC DJ48_5146 ENOG4105C22 threonyL-tRNA synthetase DJ48_5147 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DJ48_515 ENOG4105VPX protein, conserved in bacteria DJ48_5151 ENOG4105CN9 Peptidase m42 family protein DJ48_5152 ENOG4108JGH Tetr family transcriptional regulator DJ48_5153 ENOG4105CW7 secretion protein, HlyD family DJ48_5154 ENOG4105C0R drug resistance transporter emrb qaca subfamily DJ48_516 ENOG410681U heavy metal transport detoxification protein DJ48_5161 ENOG4108RWN rrna methyltransferase DJ48_5163 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DJ48_5164 ENOG4105C5S asparaginyl-tRNA synthetase DJ48_517 ENOG4105C59 p-type ATPase DJ48_5171 ENOG4105DCG PHP domain protein DJ48_5174 ENOG4105FE9 pseudouridine synthase DJ48_5176 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DJ48_5178 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DJ48_518 ENOG4105K70 DNA-binding protein DJ48_5182 ENOG4105E0A ABC, transporter DJ48_5183 ENOG4105KFN sortase, SrtB family DJ48_5186 ENOG4105DR4 Methyltransferase DJ48_5189 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DJ48_519 ENOG4105TMB Formate nitrite transporter DJ48_5198 ENOG4105S6R Iron-hydroxamate transporter permease subunit DJ48_5199 ENOG4105J76 Periplasmic binding protein DJ48_5201 ENOG4105CEY Amp-dependent synthetase and ligase DJ48_5202 ENOG4107Z3H Transcriptional regulator, TetR family DJ48_5203 ENOG41060WC Enoyl-CoA hydratase DJ48_5204 ENOG4105BZJ Electron transfer flavoprotein DJ48_5205 ENOG4105C10 Electron transfer flavoprotein DJ48_5206 ENOG4105K63 Thioredoxin DJ48_5209 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DJ48_5211 ENOG4105E33 succinate dehydrogenase DJ48_5213 ENOG4108VXD carboxy-peptidase DJ48_5214 ENOG4105E14 MotA TolQ exbB proton channel DJ48_5215 ENOG4105ER2 Ompa motb domain protein DJ48_5216 ENOG4105ER2 Ompa motb domain protein DJ48_5217 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DJ48_5218 ENOG4108IUX (ABC) transporter DJ48_5219 ENOG4105RHA ABC transporter, permease DJ48_5220 ENOG4108Z40 Transcriptional regulator DJ48_5221 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DJ48_5223 ENOG4108JCI Transcriptional regulator DJ48_5224 ENOG41067S9 phage shock protein C, PspC DJ48_5226 ENOG4105DY9 regulatoR DJ48_5227 ENOG4108HRK Histidine kinase DJ48_5228 ENOG4108JQ7 (ABC) transporter DJ48_523 ENOG4105C85 amino acid DJ48_5231 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DJ48_5232 ENOG4105DEF Extracellular solute-binding protein, family 5 DJ48_5233 ENOG4105DZC cytosine deaminase DJ48_5234 ENOG4105DZC cytosine deaminase DJ48_5237 ENOG4105PFC Transcriptional regulator DJ48_5240 ENOG4105KBX Transcriptional regulator, TetR family DJ48_5242 ENOG4108PCX Major Facilitator DJ48_5244 ENOG4108XJQ germination protein DJ48_5246 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DJ48_5247 ENOG4105M59 Phosphodiesterase, mj0936 family DJ48_5251 ENOG4108QCI YvbH-like oligomerisation region DJ48_5257 ENOG4108IUQ atp-dependent protease DJ48_526 ENOG4108SJC Membrane DJ48_5261 ENOG4105K56 Transcriptional regulator DJ48_5266 ENOG4105D52 delta-aminolevulinic acid dehydratase DJ48_5268 ENOG41068KH stage VI sporulation protein D DJ48_527 ENOG4107QW4 alcohol dehydrogenase DJ48_5270 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DJ48_5271 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DJ48_5275 ENOG4105DFF Rod shape-determining protein mreb DJ48_5276 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DJ48_5279 ENOG4107QMS site-determining protein DJ48_528 ENOG4107QW4 alcohol dehydrogenase DJ48_5282 ENOG4105C03 ribonuclease DJ48_5284 ENOG4105X36 (ribosomal) protein DJ48_529 ENOG4105E98 transcriptional regulator DeoR family DJ48_5290 ENOG4105EWM Histidine kinase DJ48_5294 ENOG4105CQC Prephenate dehydratase DJ48_5295 ENOG4108RPX mosc domain containing protein DJ48_5298 ENOG4108IYU L-aspartate oxidase DJ48_5299 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DJ48_53 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DJ48_530 ENOG4105DE4 1-phosphofructokinase DJ48_5304 ENOG41082BM Transcriptional regulator, arsr family DJ48_5305 ENOG4108IPJ Membrane DJ48_5306 ENOG4108IPJ Membrane DJ48_5308 ENOG4108HUF Transporter DJ48_531 ENOG4105DM4 PTS System DJ48_5311 ENOG41061AI Protein of unknown function (DUF2905) DJ48_5314 ENOG4105VIE preprotein translocase, subunit YajC DJ48_5316 ENOG4108QG2 Membrane DJ48_5317 ENOG4105CKP Polysaccharide Biosynthesis Protein DJ48_5319 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DJ48_532 ENOG41069ER domain protein DJ48_5320 ENOG41076HS cation diffusion facilitator family transporter DJ48_5321 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DJ48_5323 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DJ48_5326 ENOG4105CUT histidyl-tRNA synthetase DJ48_5328 ENOG4105CUZ uba thif-type nad fad binding protein DJ48_5329 ENOG4108VCI transcription factor, rsfa family DJ48_5330 ENOG4105D1H recombination factor protein RarA DJ48_5332 ENOG4105C3J Cysteine desulfurase DJ48_5335 ENOG4105C7H Helicase, RecD TraA family DJ48_5336 ENOG41060CR DJ48_5339 ENOG4105C02 permease DJ48_5341 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DJ48_5345 ENOG4105HHA aminodeoxychorismate lyase DJ48_5346 ENOG4108VQJ O-methyltransferase DJ48_5347 ENOG4105XYU peptidase (U32 family) DJ48_5348 ENOG4105CFP Peptidase U32 DJ48_5351 ENOG4107XRG penicillin-binding protein DJ48_5357 ENOG4105C28 cystathionine DJ48_5358 ENOG4108EKI Dehydrogenase DJ48_5360 ENOG4108V5C ABC transporter DJ48_5361 ENOG4105S6R Iron-hydroxamate transporter permease subunit DJ48_5369 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_5371 ENOG4105MIR Phenylalanine 4-monooxygenase DJ48_5372 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DJ48_538 ENOG4106F1P AAA ATPase, central domain protein DJ48_5380 ENOG4108MUZ hydrolase DJ48_5382 ENOG4105G6Z alkaline phosphatase DJ48_5386 ENOG4108TVJ Nitroreductase DJ48_5390 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_5392 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DJ48_5393 ENOG4105CQW ribosome biogenesis GTPase YqeH DJ48_5395 ENOG410812S Rna-binding protein DJ48_5397 ENOG4108WF2 Metal Dependent Phosphohydrolase DJ48_5399 ENOG4105DXX methyltransferase DJ48_540 ENOG4105EN6 Membrane DJ48_5401 ENOG4105KQC Competence protein DJ48_5402 ENOG4108UK2 deaminase DJ48_5403 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DJ48_5405 ENOG4105TQK DNA polymerase iii, delta' subunit DJ48_541 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DJ48_5410 ENOG4105KVH Transcriptional regulator DJ48_5411 ENOG4105CSA Coproporphyrinogen iii oxidase DJ48_5413 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DJ48_5417 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DJ48_5418 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DJ48_542 ENOG4105CXI aluminum resistance protein DJ48_5420 ENOG4105KTH gatB Yqey DJ48_5421 ENOG41068P3 sporulation protein YqfC DJ48_5423 ENOG4105C9A Phoh family DJ48_5424 ENOG4105CTJ Metal Dependent Phosphohydrolase DJ48_5426 ENOG4107YR5 Diacylglycerol kinase DJ48_5427 ENOG4105KG3 cytidine deaminase DJ48_5428 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DJ48_543 ENOG4105KV4 Transcriptional regulator DJ48_5433 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DJ48_5434 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_5437 ENOG4105EGD dinuclear metal center protein, YbgI family DJ48_544 ENOG4105C5F glutamine synthetase DJ48_5442 ENOG41069ZM Protein of unknown function (DUF2624) DJ48_5443 ENOG4108JYZ YitT family DJ48_5444 ENOG4105FDK ABC transporter DJ48_5446 ENOG4105N80 Ferric uptake regulator, Fur family DJ48_5451 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DJ48_5453 ENOG4107RF6 penicillin-binding protein DJ48_5454 ENOG4105PWN phosphate abc transporter DJ48_5455 ENOG4105C8U phosphate abc transporter DJ48_5456 ENOG4105E2Z phosphate ABC transporter (Permease DJ48_5457 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DJ48_5458 ENOG4108UTW Plays a role in the regulation of phosphate uptake DJ48_5461 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DJ48_5464 ENOG4105DKQ ROK family DJ48_5466 ENOG4105C5X domain protein DJ48_5470 ENOG4105C28 cystathionine DJ48_5471 ENOG4105C28 cystathionine DJ48_5473 ENOG4105C3R Methionine synthase DJ48_5474 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DJ48_5498 ENOG4105C0D helicase DJ48_55 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DJ48_5504 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DJ48_5505 ENOG4105CJ1 ABC, transporter DJ48_5512 ENOG41080TC multidrug resistance protein DJ48_5516 ENOG4105WZW rhodanese family DJ48_5517 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DJ48_5522 ENOG4107YBY Hydrolase DJ48_5523 ENOG4105CBJ Metal-dependent enzyme DJ48_5526 ENOG4105DC7 peptidase M24 DJ48_5531 ENOG4105CD2 stage iii sporulation protein aa DJ48_5532 ENOG4105KR5 Stage iii sporulation protein DJ48_5533 ENOG4108CQH stage III sporulation protein AC DJ48_5534 ENOG4105KQ4 Stage iii sporulation protein ad DJ48_5536 ENOG410644B Stage III sporulation protein af DJ48_5541 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DJ48_5542 ENOG4108ZSR alkaline shock protein DJ48_5547 ENOG4105CTB Polyprenyl synthetase DJ48_5560 ENOG4107QJE Chromosome Partitioning Protein DJ48_5565 ENOG4105DQ6 Transposase DJ48_5571 ENOG4105EWC Purine nucleoside phosphorylase DJ48_5589 ENOG4105C3F Signal peptidase i DJ48_5595 ENOG4105N14 lysine exporter protein LysE YggA DJ48_56 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DJ48_5601 ENOG4108J59 Extracellular solute-binding protein, family 5 DJ48_5604 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DJ48_5614 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DJ48_5615 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DJ48_5629 ENOG4105K4H Nlp p60 protein DJ48_564 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) DJ48_57 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DJ48_58 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DJ48_6 ENOG4107QQR Sporulation DJ48_602 ENOG4105XSJ toxin secretion phage lysis holin DJ48_603 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DJ48_611 ENOG4105K7K Transcriptional regulator DJ48_615 ENOG4108SVB resolvase DJ48_617 ENOG4105CGH 5'-nucleotidase DJ48_62 ENOG4108R6K riboflavin synthase, subunit alpha DJ48_620 ENOG4105D5T phosphonate abc transporter DJ48_623 ENOG4105D7V transposase DJ48_627 ENOG4105BZ1 (ABC) transporter DJ48_628 ENOG4105BZ1 (ABC) transporter DJ48_63 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DJ48_631 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DJ48_636 ENOG41067MG lrgb family DJ48_638 ENOG4107RSM transcriptional regulator DJ48_640 ENOG4105CJ1 ABC, transporter DJ48_642 ENOG4105CH2 amidohydrolase DJ48_644 ENOG4107QIV Cytochrome c biogenesis protein DJ48_652 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DJ48_657 ENOG4108903 Formimidoylglutamase DJ48_658 ENOG4108VJ1 Transcriptional regulator (CarD family DJ48_659 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DJ48_660 ENOG4105CBC glutamate synthase DJ48_661 ENOG4105CK7 Sodium proline symporter DJ48_662 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DJ48_663 ENOG4105FBA Phospholipase Carboxylesterase DJ48_664 ENOG4105BZU Histidine kinase DJ48_666 ENOG4107AYK membrAne DJ48_67 ENOG4108YM7 Gcn5-related n-acetyltransferase DJ48_675 ENOG4105CEY Amp-dependent synthetase and ligase DJ48_676 ENOG4107ZYJ bioY protein DJ48_677 ENOG4107F3J Amp-dependent synthetase and ligase DJ48_68 ENOG4105ETE Transcriptional regulator (LacI family DJ48_681 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DJ48_683 ENOG4105E5W Transporter DJ48_689 ENOG4108I0Z Aconitate hydratase DJ48_690 ENOG4108JJA ABC, transporter DJ48_692 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DJ48_693 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DJ48_699 ENOG4105W8X HesB YadR YfhF-family protein DJ48_70 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DJ48_700 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DJ48_701 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DJ48_703 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DJ48_704 ENOG4105C0H protease DJ48_705 ENOG4105K4P CoA-binding domain protein DJ48_706 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DJ48_708 ENOG4105D9R oxidoreductase DJ48_710 ENOG4105CIG ABC transporter DJ48_713 ENOG4105EMN RNA polymerase sigma factor DJ48_715 ENOG4108KGH TRANSCRIPTIONal DJ48_716 ENOG4108KGH TRANSCRIPTIONal DJ48_717 ENOG4107QJT sodium dicarboxylate symporter DJ48_729 ENOG4105E1K spore germination protein DJ48_731 ENOG4108JB9 formate dehydrogenase DJ48_733 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DJ48_734 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DJ48_736 ENOG4105TMB Formate nitrite transporter DJ48_737 ENOG4105D06 uba thif-type nad fad binding protein DJ48_738 ENOG4105D06 uba thif-type nad fad binding protein DJ48_739 ENOG4105CVM Molybdenum cofactor synthesis domain protein DJ48_74 ENOG4105RHY Pfam:UPF0157 DJ48_740 ENOG4108ZAF Molybdopterin DJ48_742 ENOG4105D1F ATP-binding protein DJ48_745 ENOG410696E Membrane DJ48_746 ENOG4105FR1 rard protein DJ48_748 ENOG4105EWU Squalene--hopene cyclase DJ48_750 ENOG4105CHR reductase DJ48_751 ENOG4105C26 Dehydrogenase DJ48_753 ENOG4108IA2 Sodium pantothenate symporter DJ48_756 ENOG4106IQC argininosuccinate lyase DJ48_758 ENOG410904N short-chain dehydrogenase reductase DJ48_76 ENOG4105CPC Aldo Keto reductase DJ48_764 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DJ48_768 ENOG4105VEQ Cold shock protein DJ48_772 ENOG4108R1P DJ48_774 ENOG41073R8 VanW family DJ48_775 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_777 ENOG4105KT7 mgtC SapB transporter DJ48_779 ENOG4105E39 Enoyl-CoA hydratase DJ48_780 ENOG4105K64 Glycosyl transferase, family 2 DJ48_782 ENOG4108UT6 Transferase hexapeptide repeat containing protein DJ48_786 ENOG4105CQB FAD linked oxidase domain protein DJ48_787 ENOG4105C09 Bile acid DJ48_789 ENOG4105RHY Pfam:UPF0157 DJ48_794 ENOG4105CIS alcohol dehydrogenase DJ48_795 ENOG41082BM Transcriptional regulator, arsr family DJ48_799 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DJ48_80 ENOG4105MZ9 stage II sporulation protein m DJ48_805 ENOG4108A04 Beta-lactamase DJ48_806 ENOG4105DPN Oligoendopeptidase f DJ48_807 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DJ48_808 ENOG4105E5K Alpha-amylase DJ48_81 ENOG4105I3K Ferric uptake regulator, Fur family DJ48_810 ENOG4105C98 muts2 protein DJ48_814 ENOG4107V2S Transcriptional regulator DJ48_816 ENOG4107CUJ Protein of unknown function (DUF2690) DJ48_820 ENOG4107ZY0 Phenazine biosynthesis-like protein DJ48_821 ENOG4105NX3 Membrane DJ48_822 ENOG4105DQ5 transport system permease protein DJ48_823 ENOG4105EHG Permease protein DJ48_824 ENOG4108MES Periplasmic binding protein DJ48_828 ENOG4107R3E Citrate transporter DJ48_83 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DJ48_830 ENOG4108TN2 lmbE family DJ48_837 ENOG4105CIS alcohol dehydrogenase DJ48_844 ENOG4105H3G oxidoreductase DJ48_846 ENOG4105ED2 Beta-lactamase DJ48_851 ENOG4107YXZ hydrolase, family 25 DJ48_855 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DJ48_860 ENOG4105KAF membrAne DJ48_870 ENOG4108ZJ4 polysaccharide deacetylase DJ48_874 ENOG4105KVH Transcriptional regulator DJ48_875 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DJ48_88 ENOG4105D7N magnesium and cobalt transport protein CorA DJ48_880 ENOG4105CHR reductase DJ48_882 ENOG4105JAB phenazine biosynthesis protein, phzf family DJ48_889 ENOG4105KVH Transcriptional regulator DJ48_890 ENOG4105KVH Transcriptional regulator DJ48_891 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DJ48_892 ENOG4105D9R oxidoreductase DJ48_893 ENOG4108TZY GntR Family Transcriptional Regulator DJ48_894 ENOG4105KVH Transcriptional regulator DJ48_9 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DJ48_900 ENOG4105C44 Serine transporter DJ48_901 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DJ48_904 ENOG4105F27 Major Facilitator DJ48_905 ENOG4105CV8 reductase DJ48_909 ENOG4105D4Y metalloprotease DJ48_910 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DJ48_913 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DJ48_914 ENOG4105CIS alcohol dehydrogenase DJ48_915 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DJ48_916 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DJ48_918 ENOG4105CV1 Transketolase (EC 2.2.1.1) DJ48_920 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DJ48_921 ENOG4105C6Z Gluconate DJ48_922 ENOG4105CMG Carbohydrate kinase DJ48_923 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DJ48_924 ENOG4105XDF Protein of unknown function (DUF1272) DJ48_925 ENOG4105DDN Pentapeptide repeat-containing protein DJ48_928 ENOG4105C37 (CBS) domain DJ48_934 ENOG4105EV4 Multidrug resistance protein mdtH DJ48_936 ENOG4105DMQ Methyltransferase DJ48_94 ENOG4105DVE abc transporter atp-binding protein DJ48_942 ENOG4105C31 Tryptophanyl-tRNA synthetase DJ48_944 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DJ48_946 ENOG4108UW5 maltose o-acetyltransferase DJ48_947 ENOG4106UW1 Major Facilitator superfamily DJ48_948 ENOG4105DKQ ROK family DJ48_949 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DJ48_95 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DJ48_96 ENOG4105DZ1 carboxypeptidase DJ48_961 ENOG4105CJ1 ABC, transporter DJ48_963 ENOG4108PSK reductase DJ48_967 ENOG4108RCM Nitroreductase DJ48_968 ENOG4105KVH Transcriptional regulator DJ48_97 ENOG41082AN stage II sporulation protein DJ48_971 ENOG4105CUT histidyl-tRNA synthetase DJ48_972 ENOG4108Z66 YbaK ebsC protein DJ48_974 ENOG41067QW Transcriptional regulator DJ48_977 ENOG4108K8S endonuclease I DJ48_982 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DJ48_983 ENOG4108JJB ABC transporter DJ48_989 ENOG4105DYS nad(p)h dehydrogenase (quinone) DJ48_99 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DJ48_991 ENOG4105CRW Short chain fatty acid transporter DJ48_993 ENOG4105KBX Transcriptional regulator, TetR family DJ48_994 ENOG4105KPY Small multidrug resistance protein DJ48_995 ENOG4105RXJ DJ48_997 ENOG41069JR DJ48_999 ENOG4105DA5 (ABC) transporter