locus-tag class description BF27_1 ENOG4105C0X amino acid BF27_100 ENOG4107QIV Cytochrome c biogenesis protein BF27_1008 ENOG4108MRH transcriptional regulatory protein BF27_1010 ENOG4105CSH Transporter BF27_1016 ENOG4108JQ7 (ABC) transporter BF27_1019 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF27_1027 ENOG4105CTU Proline racemase BF27_1031 ENOG4105DER m42 family BF27_1035 ENOG4105CGU Enoyl-CoA hydratase BF27_1038 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF27_1039 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF27_104 ENOG4105EC3 peptidase S51, dipeptidase E BF27_1041 ENOG4106AKK s-layer domain-containing protein BF27_1049 ENOG4105CHH sulfate transporter BF27_105 ENOG4107QJQ Mate efflux family protein BF27_1052 ENOG4105D4P Coproporphyrinogen iii oxidase BF27_1054 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF27_1059 ENOG4107FQX Alpha-acetolactate decarboxylase BF27_1066 ENOG410839P BF27_1069 ENOG4105CDA abc transporter atp-binding protein BF27_1070 ENOG4105DRP amino acid AbC transporter BF27_1072 ENOG4105BZ1 (ABC) transporter BF27_1073 ENOG4105BZ1 (ABC) transporter BF27_1074 ENOG4105BZ1 (ABC) transporter BF27_1075 ENOG4105C26 Dehydrogenase BF27_1077 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF27_1078 ENOG4105D5Q Arginine ornithine antiporter BF27_1080 ENOG4105CH6 catalase BF27_1081 ENOG4107RKG DJ-1/PfpI family BF27_1083 ENOG4105E5W Transporter BF27_1084 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF27_1085 ENOG4105NF4 modulator of drug activity BF27_109 ENOG4105C9Q fumarate hydratase class II BF27_1090 ENOG4105KPY Small multidrug resistance protein BF27_1091 ENOG4105KPY Small multidrug resistance protein BF27_1093 ENOG4108YXU transcriptional regulator AsnC family BF27_1094 ENOG4108PCN EamA-like transporter family BF27_11 ENOG41068WN BF27_110 ENOG4105DFD Na H antiporter BF27_1101 ENOG4106KNT transcriptional regulator BF27_1103 ENOG4107RWR Sodium hydrogen exchanger BF27_1104 ENOG4105CUB amino acid BF27_1111 ENOG4107T5V SNARE associated Golgi BF27_1118 ENOG4105WEF catalase BF27_1124 ENOG4105C19 ABC transporter BF27_1125 ENOG4107RBB ABC transporter, permease BF27_1126 ENOG41069ER domain protein BF27_113 ENOG4108PJD permease BF27_1130 ENOG4105VZJ PTS System BF27_1131 ENOG4105VCP PTS System BF27_1132 ENOG4105EMD TRANSCRIPTIONal BF27_1137 ENOG4108KGH TRANSCRIPTIONal BF27_1139 ENOG41087NI Sulfite exporter TauE/SafE BF27_114 ENOG4105CKI cobalamin synthesis protein BF27_1140 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF27_1142 ENOG41085GJ domain protein BF27_1144 ENOG4105VFE sira family BF27_1145 ENOG4107TPS domain protein BF27_1146 ENOG4105VFE sira family BF27_1147 ENOG4105XTG Pfam:DUF156 BF27_1148 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF27_115 ENOG4108UZ3 Transporter BF27_1153 ENOG4105ED1 spovr family BF27_1154 ENOG4107Y03 Nitroreductase BF27_1158 ENOG4108B31 Spore germination protein BF27_116 ENOG4105DRR Transcriptional regulator, GntR family BF27_1165 ENOG4105C5Y PTS System BF27_1169 ENOG4108PXI ErfK YbiS YcfS YnhG BF27_1171 ENOG4105C7N Xanthine uracil vitamin C permease BF27_1174 ENOG4108INS Transcriptional regulator BF27_118 ENOG4105PGM cation diffusion facilitator family transporter BF27_1183 ENOG4105DWF phosphomethylpyrimidine kinase BF27_1184 ENOG4105D06 uba thif-type nad fad binding protein BF27_1187 ENOG41080HI glycine oxidase BF27_1188 ENOG4108VEU Thiamine monophosphate synthase BF27_1190 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF27_1192 ENOG4105ETU transcriptional activator (TenA BF27_1196 ENOG41080XQ Signal transduction protein with cbs domains BF27_122 ENOG4105CAQ asparagine synthetase BF27_1221 ENOG4105E2Z phosphate ABC transporter (Permease BF27_1222 ENOG4105C8U phosphate abc transporter BF27_1223 ENOG4105CVA phosphate BF27_1224 ENOG4105CE1 Ferrous iron transport protein b BF27_1225 ENOG4105CE1 Ferrous iron transport protein b BF27_1226 ENOG4105CE1 Ferrous iron transport protein b BF27_1227 ENOG4108NHD germination protein BF27_1230 ENOG4105E1V na solute symporter BF27_1231 ENOG4106CAD Protein of unknown function (DUF3311) BF27_1235 ENOG4105E2S oxidase) subunit II BF27_1236 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF27_124 ENOG4105K56 Transcriptional regulator BF27_1244 ENOG4105C7N Xanthine uracil vitamin C permease BF27_1245 ENOG4105C85 amino acid BF27_1250 ENOG4105DUX Transporter BF27_1252 ENOG4107D63 BF27_1253 ENOG4105VZ8 Transcriptional regulator BF27_1254 ENOG41069ER domain protein BF27_1255 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF27_1256 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF27_1268 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF27_1269 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF27_1270 ENOG4105CNN ABC, transporter BF27_1271 ENOG4105C2J ABC transporter BF27_1273 ENOG4108RVA ribokinase BF27_1274 ENOG4105ETE Transcriptional regulator (LacI family BF27_1275 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_1276 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_1277 ENOG41067TZ transcriptional regulator, MarR family BF27_1278 ENOG4105CXY transporter BF27_128 ENOG4105CVJ phosphoglycerate mutase BF27_1280 ENOG4108JQ7 (ABC) transporter BF27_1281 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF27_1283 ENOG4105DEF Extracellular solute-binding protein, family 5 BF27_1285 ENOG41068KF Universal stress protein BF27_1286 ENOG4105CHH sulfate transporter BF27_1289 ENOG4105BZU Histidine kinase BF27_1290 ENOG4105NAE bifunctional deaminase-reductase domain protein BF27_1291 ENOG4105D29 Helix-turn-helix type 11 domain protein BF27_1296 ENOG4108IQI permease BF27_1297 ENOG4105DRP amino acid AbC transporter BF27_1298 ENOG4105EAD ABC transporter BF27_1299 ENOG4105CT1 (ABC) transporter BF27_1300 ENOG4105CDA abc transporter atp-binding protein BF27_1301 ENOG4105BZG amino acid carrier protein BF27_1302 ENOG4105CRN Aminoglycoside phosphotransferase BF27_1304 ENOG4105E1K spore germination protein BF27_1307 ENOG4105CG3 alpha amylase, catalytic region BF27_1308 ENOG4105C5Y PTS System BF27_1309 ENOG4107414 GntR family transcriptional regulator BF27_1310 ENOG4105D5Q Arginine ornithine antiporter BF27_1311 ENOG4105BZU Histidine kinase BF27_1314 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF27_1315 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF27_1316 ENOG4107T89 von Willebrand factor, type A BF27_1318 ENOG4105EXW epimerase dehydratase BF27_1320 ENOG4105DMQ Methyltransferase BF27_1321 ENOG4105E0A ABC, transporter BF27_1322 ENOG4108IHU transport system permease protein BF27_1323 ENOG4105DQ5 transport system permease protein BF27_1324 ENOG4108MES Periplasmic binding protein BF27_1325 ENOG4105DUX Transporter BF27_1328 ENOG4105DAA L-lactate BF27_1329 ENOG4108IJ0 Aspartate ammonia-lyase BF27_1330 ENOG4105C37 (CBS) domain BF27_1331 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF27_1332 ENOG4105D9N nucleoside BF27_1333 ENOG4108KGH TRANSCRIPTIONal BF27_1334 ENOG41073R8 VanW family BF27_1341 ENOG4105DAP Nicotinate phosphoribosyltransferase BF27_1342 ENOG4105C59 p-type ATPase BF27_1344 ENOG4105CUB amino acid BF27_1348 ENOG4108JB9 formate dehydrogenase BF27_1349 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF27_135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF27_1350 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF27_1352 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_1353 ENOG4105BZU Histidine kinase BF27_1355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF27_1356 ENOG4108UZ3 Transporter BF27_1358 ENOG4105C6K Malic enzyme BF27_136 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF27_1360 ENOG4108MRH transcriptional regulatory protein BF27_1365 ENOG4105US7 Histidine kinase BF27_1366 ENOG4108STX response regulator BF27_1367 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF27_1368 ENOG4105BZ7 extracellular solute-binding protein family 1 BF27_1369 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF27_137 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF27_1370 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF27_1371 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF27_1372 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF27_1376 ENOG4105D4T Citrate transporter BF27_1377 ENOG4108MRH transcriptional regulatory protein BF27_1378 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF27_138 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF27_1381 ENOG4105DZ6 Band 7 protein BF27_1384 ENOG4105C94 Transporter BF27_1388 ENOG4105CYN Serine protein kinase BF27_139 ENOG4105DUM transcriptional regulator, lysR family BF27_1390 ENOG4105BZU Histidine kinase BF27_1391 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF27_1393 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF27_1395 ENOG4107ZQN disulfide bond BF27_1417 ENOG4105G5W regulator Fur family BF27_1418 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF27_1422 ENOG4108IUW ABC transporter BF27_1424 ENOG4105CBC glutamate synthase BF27_1425 ENOG4107NBY Membrane BF27_1426 ENOG4105BZ1 (ABC) transporter BF27_1430 ENOG4106BXE BF27_1431 ENOG4105CEN a g-specific adenine glycosylase BF27_1432 ENOG41067AE Membrane-bound metal-dependent hydrolase BF27_1438 ENOG4105ECP epimerase BF27_1439 ENOG4105CI2 imidazolone-5-propionate hydrolase BF27_1443 ENOG4105F1A Pyruvate formate-lyase BF27_1446 ENOG4105C3I Nad-dependent epimerase dehydratase BF27_1449 ENOG4105CKK Glycosyl transferase, family 2 BF27_145 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF27_1452 ENOG4108A04 Beta-lactamase BF27_1454 ENOG4105CSV Glutaminase BF27_1460 ENOG4108IQI permease BF27_1462 ENOG4108JUB Transcriptional regulator BF27_1464 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF27_149 ENOG4108RZE Tetr family transcriptional regulator BF27_1524 ENOG4105VTR Integrase BF27_1525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF27_1533 ENOG4105UPD Calcium Proton BF27_1534 ENOG410606W general stress protein BF27_1537 ENOG4107ZTW SNARE associated Golgi BF27_154 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF27_1541 ENOG4108IPJ Membrane BF27_1542 ENOG4105C59 p-type ATPase BF27_1543 ENOG4107U9T Pfam:Ribonuclease_BN BF27_1545 ENOG4105KJF protein tyrosine phosphatase BF27_155 ENOG4105KTQ flagellar basal-body rod protein BF27_1551 ENOG4107TS3 membrane protein, TerC BF27_1552 ENOG4106FN3 tellurium resistance protein BF27_1553 ENOG4106FN3 tellurium resistance protein BF27_1554 ENOG4108N0M stress protein BF27_1557 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF27_156 ENOG4105FZW flagellar biosynthesis regulator FlhF BF27_1561 ENOG4105DEU major facilitator superfamily BF27_1565 ENOG41062JF Transcriptional regulator BF27_157 ENOG4105D7B Flagellar biosynthesis protein flha BF27_1570 ENOG4105C5H ABC transporter BF27_1574 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF27_1577 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF27_158 ENOG4105D00 flagellar biosynthetic protein flhB BF27_1583 ENOG4105CI1 PTS System BF27_1585 ENOG4105C8Q Methyl-accepting chemotaxis BF27_1586 ENOG4105C8Q Methyl-accepting chemotaxis BF27_1588 ENOG4105EAB amino acid AbC transporter BF27_1589 ENOG4105E5Q amino acid AbC transporter BF27_1592 ENOG4105D2S major facilitator superfamily BF27_1593 ENOG410756H nucleotidyltransferase BF27_1597 ENOG4105BZU Histidine kinase BF27_160 ENOG4105VS8 Flagellar biosynthetic protein fliq BF27_1601 ENOG4106UIA BF27_1602 ENOG4106UIA BF27_1606 ENOG4108V5C ABC transporter BF27_1607 ENOG4105DQ5 transport system permease protein BF27_1608 ENOG4105EHG Permease protein BF27_1609 ENOG4107W7X Aldolase BF27_161 ENOG4105CN7 Flagellar biosynthetic protein FliP BF27_1611 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF27_1612 ENOG4105D3R alkyl hydroperoxide reductase BF27_1617 ENOG4105DFD Na H antiporter BF27_1618 ENOG4105DTQ mandelate racemase muconate lactonizing BF27_1621 ENOG4108W15 Protein of unknown function (DUF1456) BF27_1624 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF27_1625 ENOG4105D9N nucleoside BF27_1629 ENOG4105KPY Small multidrug resistance protein BF27_163 ENOG4105DD5 Flagellar motor switch protein BF27_1630 ENOG4105C26 Dehydrogenase BF27_1632 ENOG4108JPW Aminotransferase BF27_1633 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF27_1634 ENOG4105CBD Diacylglycerol kinase BF27_1638 ENOG4107I77 yiaA/B two helix domain BF27_1639 ENOG410834F Transcriptional regulator BF27_164 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF27_1643 ENOG4105D01 (LipO)protein BF27_1644 ENOG4108UMI ABC transporter, permease BF27_1645 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF27_1646 ENOG4108W2Y isochorismatase BF27_1652 ENOG4105C4R Atp-dependent dna helicase BF27_1657 ENOG4105C12 Phosphoribosylglycinamide synthetase BF27_1659 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF27_1664 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF27_1666 ENOG4105C83 adenylosuccinate lyase BF27_1667 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF27_1668 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF27_167 ENOG4105I03 Flagellin BF27_1671 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_1675 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF27_1680 ENOG4108SHN Glycosyl transferase, family 2 BF27_1685 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF27_1691 ENOG4105BZU Histidine kinase BF27_1693 ENOG4105C7N Xanthine uracil vitamin C permease BF27_1697 ENOG4108TYN CAAX amino terminal protease family protein BF27_17 ENOG4105F6J Alpha beta hydrolase fold BF27_1700 ENOG4105C5H ABC transporter BF27_1701 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF27_1702 ENOG410801F ribosomal-protein-alanine acetyltransferase BF27_1703 ENOG41072GX Peptidase M22 Glycoprotease BF27_1704 ENOG4105K8N protein family UPF0079, ATPase BF27_172 ENOG4107TVC Glycosyl transferase, family 2 BF27_1746 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF27_1748 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF27_1749 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF27_1752 ENOG4107ZXI Rhomboid family BF27_1754 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF27_1755 ENOG4105CPF Cell wall formation (By similarity) BF27_1756 ENOG4108SC4 )-transporter BF27_1758 ENOG4105ERH Fumarylacetoacetate hydrolase BF27_1759 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF27_1765 ENOG410667J hydrolase BF27_1766 ENOG4108JQ7 (ABC) transporter BF27_1767 ENOG4105C3U ABC transporter BF27_1768 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF27_1770 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF27_1773 ENOG4105C5H ABC transporter BF27_1777 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF27_1778 ENOG4108RE7 deoxyribonuclease BF27_178 ENOG4105K64 Glycosyl transferase, family 2 BF27_1781 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF27_1785 ENOG4105F6E Acyl-transferase BF27_1792 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF27_1793 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF27_1794 ENOG4105E0C molybdate abc transporter BF27_1796 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF27_1797 ENOG4105II7 pyrroline-5-carboxylate reductase BF27_1799 ENOG4108J59 Extracellular solute-binding protein, family 5 BF27_180 ENOG4107R88 Chemotaxis protein (CheV) BF27_1800 ENOG4108J59 Extracellular solute-binding protein, family 5 BF27_1806 ENOG4108JQ7 (ABC) transporter BF27_1807 ENOG4105C3U ABC transporter BF27_1808 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF27_1809 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF27_1812 ENOG4105C2C drug resistance transporter, Bcr CflA BF27_1815 ENOG4105IQ5 FAD linked oxidase domain protein BF27_1817 ENOG4105EE1 crotonyl-CoA reductase BF27_1818 ENOG4105D01 (LipO)protein BF27_1819 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF27_1820 ENOG4108UMI ABC transporter, permease BF27_1821 ENOG4108PSK reductase BF27_1827 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF27_1828 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF27_183 ENOG4105BZE flagellar hook protein, FlgE BF27_1830 ENOG4105CMG Carbohydrate kinase BF27_1832 ENOG4108VQT Alpha beta hydrolase fold protein BF27_1833 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF27_1835 ENOG4107U5W ybbr family BF27_1836 ENOG4105C8B TIGR00159 family BF27_1854 ENOG4108NMV polysaccharide deacetylase BF27_1857 ENOG4105D1F ATP-binding protein BF27_1862 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF27_1863 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF27_1864 ENOG4108JJB ABC transporter BF27_1870 ENOG41067V7 50S ribosomal protein L36 BF27_1872 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF27_1874 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF27_1879 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF27_189 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF27_190 ENOG4107U2N Flagellar M-ring protein BF27_1900 ENOG4105XPM ribosomal protein BF27_1901 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF27_1903 ENOG4107Y49 methyltransferase BF27_1908 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF27_191 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF27_1910 ENOG4105QIV RNA polymerase BF27_1911 ENOG4105M0M Tetracycline resistance protein BF27_1912 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF27_1915 ENOG4105D7W serine acetyltransferase BF27_1919 ENOG4105CTP PilT protein domain protein BF27_192 ENOG4108ZC9 flagellar basal-body rod protein flgc BF27_1921 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF27_1924 ENOG4108Z0C Uvrb UvrC protein BF27_193 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF27_1931 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF27_1933 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF27_1934 ENOG4105KRF dihydroneopterin aldolase BF27_1935 ENOG4105EEI dihydropteroate synthase BF27_1936 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF27_1937 ENOG4105DDQ anthranilate synthase BF27_1938 ENOG4105CRQ synthase (Component I) BF27_1939 ENOG4105C6T cysteine synthase BF27_1942 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF27_1943 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF27_1944 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF27_1948 ENOG41060GV RNA binding s1 domain protein BF27_1951 ENOG4105VYY sporulation protein yabp BF27_1952 ENOG41082I2 s4 domain protein BF27_1953 ENOG4108IY2 MazG family BF27_1955 ENOG4108M14 stage v sporulation protein t BF27_1956 ENOG4108JA2 transcriptioN-repair coupling factor BF27_1957 ENOG4108JA2 transcriptioN-repair coupling factor BF27_1959 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF27_1960 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF27_1963 ENOG4105KME endoribonuclease L-psp BF27_1964 ENOG4105DFT pur operon repressor BF27_1967 ENOG4105W42 Veg protein BF27_1968 ENOG4105XFA sporulation peptidase YabG BF27_197 ENOG4105DTJ flagellar hook-associated protein BF27_1970 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF27_1971 ENOG4105F8V Hydrolase, tatD family BF27_1973 ENOG4105KRN Transcriptional regulator, abrb family BF27_1974 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF27_1976 ENOG41060K3 Methyltransferase BF27_1978 ENOG4105MA4 psp1 domain protein BF27_1979 ENOG4105FA2 dna polymerase iii BF27_198 ENOG4105E1Q flagellar hook-associated protein BF27_1981 ENOG4105CXN decarboxylase BF27_1989 ENOG41067KS pro-sigma K processing BF27_1993 ENOG4105C6E dna polymerase iii BF27_1994 ENOG4108Z6B deaminase BF27_1995 ENOG4105GTG Isochorismatase BF27_1997 ENOG4105ZMH deoxynucleoside kinase BF27_2 ENOG4105C0X amino acid BF27_2004 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF27_2012 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF27_2015 ENOG410848D S4 domain protein YaaA BF27_2016 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF27_202 ENOG4105BZU Histidine kinase BF27_2020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF27_2022 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF27_2026 ENOG4107QJE Chromosome Partitioning Protein BF27_2027 ENOG4105FA0 parb-like partition protein BF27_2028 ENOG4108ZDA Sporulation protein YyaC BF27_2029 ENOG4105D8X mechanosensitive ion channel BF27_2030 ENOG4105VDK protein, conserved in bacteria BF27_2031 ENOG4105C3G gtp-binding protein BF27_2033 ENOG4108UUM single-stranded DNA-binding protein BF27_2035 ENOG4108XMW Membrane BF27_2036 ENOG4105BZR domain protein BF27_2038 ENOG4105CDU Replicative dna helicase BF27_2044 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_2045 ENOG4105BZU Histidine kinase BF27_2048 ENOG4105Q2H domain protein BF27_2049 ENOG4105C0H protease BF27_205 ENOG4105DD5 Flagellar motor switch protein BF27_2053 ENOG4105DPN Oligoendopeptidase f BF27_2056 ENOG4105C1J atp-dependent rna helicase BF27_2058 ENOG4108UT2 hemolysin iii BF27_2059 ENOG4105CMR udp-glucose 4-epimerase BF27_206 ENOG4105CBS Chea signal transduction histidine kinase BF27_2061 ENOG4105IW1 AmiS UreI transporter BF27_2063 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF27_2066 ENOG4107RGD Major Facilitator superfamily BF27_2067 ENOG4108HRK Histidine kinase BF27_2068 ENOG4105DY9 regulatoR BF27_207 ENOG4107YTP response regulator receiver protein BF27_2071 ENOG4106F5Q Membrane BF27_2072 ENOG4105E0X reductase BF27_2074 ENOG41067SE Tetr family transcriptional regulator BF27_2075 ENOG4105CKK Glycosyl transferase, family 2 BF27_208 ENOG4105ER2 Ompa motb domain protein BF27_2080 ENOG4105C5H ABC transporter BF27_2081 ENOG4105JEU Glycosyl transferase, family 2 BF27_2083 ENOG4108S4H thioesterase Superfamily protein BF27_2085 ENOG4106YBV Methyl-accepting chemotaxis BF27_2086 ENOG4105EN6 Membrane BF27_209 ENOG4107R0U MotA TolQ exbB proton channel BF27_2090 ENOG41079KZ Major Facilitator Superfamily BF27_2091 ENOG4105DY9 regulatoR BF27_2092 ENOG4105D22 carbon starvation protein BF27_2093 ENOG4105VCD cytoplasmic protein BF27_2094 ENOG4105BZU Histidine kinase BF27_2095 ENOG4105DWF phosphomethylpyrimidine kinase BF27_2096 ENOG4105BZU Histidine kinase BF27_2097 ENOG4105BZU Histidine kinase BF27_2098 ENOG4105WH1 Two component transcriptional regulator luxr family BF27_21 ENOG4105CYC Transferase BF27_2100 ENOG4108Y4K DNA-binding transcriptional activator BF27_2105 ENOG4105D6E homoserine dehydrogenase BF27_2108 ENOG41090WU lipolytic protein G-D-S-L family BF27_2109 ENOG4105CJ1 ABC, transporter BF27_211 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF27_2110 ENOG4108TU7 Inherit from COG: (ABC) transporter BF27_2112 ENOG4105VCH membrane BF27_2113 ENOG410667J hydrolase BF27_2115 ENOG4107SVH Potassium channel protein BF27_2119 ENOG4108VKI Cell wall hydrolase BF27_2122 ENOG4108IJ2 phosphate acetyltransferase BF27_2125 ENOG4108VCI transcription factor, rsfa family BF27_2127 ENOG4105DQ5 transport system permease protein BF27_2128 ENOG4105EHG Permease protein BF27_2129 ENOG4105E0A ABC, transporter BF27_2130 ENOG4108MES Periplasmic binding protein BF27_2131 ENOG4105DCI Phosphohydrolase BF27_2132 ENOG41069HH 4-oxalocrotonate tautomerase BF27_2133 ENOG4108Z4T Peptidase M50 BF27_2134 ENOG4108XFG YwhD family BF27_2135 ENOG4105BZ4 penicillin-binding protein BF27_2136 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF27_2137 ENOG4107SWG transcriptional regulator MERR family BF27_2138 ENOG4105DXB Major Facilitator superfamily BF27_2140 ENOG4105CYW agmatinase BF27_2144 ENOG410684U Domain of unknown function (DUF1934) BF27_2146 ENOG4105EMN RNA polymerase sigma factor BF27_2150 ENOG4105IIU Aminopeptidase BF27_2153 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF27_2154 ENOG4108M15 ABC transporter BF27_2155 ENOG4105KCT ABC transporter BF27_2156 ENOG4105BZU Histidine kinase BF27_2161 ENOG4105BZU Histidine kinase BF27_2164 ENOG4105DF6 Fe-S oxidoreductase BF27_2166 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF27_2167 ENOG4105C1G acyl-Coa dehydrogenase BF27_2168 ENOG4105C1G acyl-Coa dehydrogenase BF27_2175 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF27_2176 ENOG4105CBT Fructose-1,6-bisphosphatase BF27_2177 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF27_2180 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF27_2181 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF27_2182 ENOG4108ZXQ stage ii sporulation protein r BF27_2184 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF27_2187 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF27_2188 ENOG4108VGI doxx family BF27_2191 ENOG4108YZG isomerase BF27_2196 ENOG41062M3 atp synthase BF27_2197 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF27_22 ENOG4105DY9 regulatoR BF27_2207 ENOG4105BZU Histidine kinase BF27_2208 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF27_2210 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF27_2211 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF27_2216 ENOG4105D65 subunit l BF27_2217 ENOG4105C8S subunit m BF27_2218 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF27_2219 ENOG4106778 Protein of unknown function (DUF1146) BF27_2223 ENOG4105DY9 regulatoR BF27_2226 ENOG4105FRN stage II sporulation protein BF27_2228 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF27_223 ENOG41080C8 DUF218 domain BF27_2238 ENOG4105EY8 ABC transporter BF27_2239 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF27_224 ENOG4105H67 Protein of unknown function (DUF421) BF27_2243 ENOG4105CMR udp-glucose 4-epimerase BF27_2244 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_2245 ENOG4105BZU Histidine kinase BF27_2248 ENOG4105CXY transporter BF27_2252 ENOG4105C19 ABC transporter BF27_2253 ENOG4107RBB ABC transporter, permease BF27_2255 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_226 ENOG4108Z5V transcriptional regulator, merr family BF27_2261 ENOG4105C0D helicase BF27_2262 ENOG4105KBK Zinc finger, swim domain protein BF27_2267 ENOG41069ER domain protein BF27_2268 ENOG4105C94 Transporter BF27_227 ENOG4105CN5 Metallo-Beta-Lactamase BF27_2270 ENOG4107R8N Glycosyl transferase, family 2 BF27_2276 ENOG4105E0M Sulfatase BF27_2279 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF27_228 ENOG4107RWR Sodium hydrogen exchanger BF27_2281 ENOG4105DAA L-lactate BF27_2289 ENOG4107RSM transcriptional regulator BF27_2290 ENOG4105ECB domain protein BF27_2291 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_2294 ENOG4105VZJ PTS System BF27_2296 ENOG4105VCP PTS System BF27_2297 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF27_2298 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF27_230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF27_2300 ENOG4105CK1 PTS System BF27_2301 ENOG4105VCP PTS System BF27_2302 ENOG4105F8D glycoside hydrolase family 4 BF27_2303 ENOG410901P UPF0249 protein BF27_2306 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF27_2308 ENOG4105ESV Glycosyl transferase, family 4 BF27_2311 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF27_2312 ENOG4108KGH TRANSCRIPTIONal BF27_2313 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF27_2315 ENOG4105KVH Transcriptional regulator BF27_2318 ENOG41081UC Inherit from COG: Competence protein BF27_2319 ENOG4105VEQ Cold shock protein BF27_2320 ENOG4105MS2 ribosomal subunit Interface protein BF27_2321 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF27_2322 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF27_2324 ENOG4105CAK Cell division ATP-binding protein ftsE BF27_2325 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF27_2326 ENOG4105CN1 protease BF27_2328 ENOG4105BZ1 (ABC) transporter BF27_2331 ENOG4108WS4 fmn reductase BF27_2333 ENOG4105DUM transcriptional regulator, lysR family BF27_2334 ENOG4105HMI Membrane BF27_2339 ENOG4107TXC Transcriptional regulator BF27_2342 ENOG4105D7V transposase BF27_2343 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF27_2344 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF27_2346 ENOG41086DT Membrane protein of unknown function BF27_2350 ENOG4108S4C acetyltransferase BF27_2352 ENOG4105C3M thioredoxin reductase BF27_2354 ENOG4108Z4K mutator MutT protein BF27_2356 ENOG4105CHW UPF0052 protein BF27_2358 ENOG4105KRI phosphocarrier protein (HPr BF27_2359 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF27_2360 ENOG4105H67 Protein of unknown function (DUF421) BF27_2363 ENOG4105CZ3 stage V sporulation protein ad BF27_2364 ENOG41090VF Stage v sporulation protein ac BF27_2368 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_2373 ENOG4105CP7 Triose-phosphate isomerase BF27_2374 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF27_2376 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF27_2380 ENOG4105EFC phage portal protein HK97 family BF27_2399 ENOG41067MG lrgb family BF27_2400 ENOG4105XZU Preprotein translocase, subunit SecG BF27_2402 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF27_2407 ENOG4105CM4 permease protein BF27_2408 ENOG4108IPW abc transporter atp-binding protein BF27_2411 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF27_2412 ENOG4108MK9 spermidine N(1)-acetyltransferase BF27_2415 ENOG4105WMR Protein CrcB homolog BF27_2416 ENOG4105WMR Protein CrcB homolog BF27_2418 ENOG4105C8Q Methyl-accepting chemotaxis BF27_2420 ENOG4105D4A Cell wall formation (By similarity) BF27_2421 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF27_2424 ENOG4105KVH Transcriptional regulator BF27_2425 ENOG4105F27 Major Facilitator BF27_2426 ENOG4105CV8 reductase BF27_243 ENOG41081VK Ribonuclease BF27_2430 ENOG4108RYK Nad-dependent epimerase dehydratase BF27_2433 ENOG4105D9N nucleoside BF27_2434 ENOG4105D9N nucleoside BF27_2439 ENOG4108URH decarboxylase BF27_2442 ENOG4108RMU ferritin dps family protein BF27_2444 ENOG4105NCW Trka-c domain protein BF27_2445 ENOG4107S91 Sodium hydrogen exchanger BF27_2449 ENOG4105D4Y metalloprotease BF27_2450 ENOG4105VG1 fes assembly suf system protein BF27_2453 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF27_2455 ENOG4105BZU Histidine kinase BF27_2456 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_2457 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF27_2459 ENOG4107ZTW SNARE associated Golgi BF27_2466 ENOG4107AYK membrAne BF27_2468 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF27_247 ENOG4108SZE gCN5-related N-acetyltransferase BF27_2470 ENOG4107R7I amino acid BF27_2471 ENOG4108SUT Major Facilitator Superfamily BF27_2476 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF27_2480 ENOG4105DZ1 carboxypeptidase BF27_2483 ENOG4105CHU acetyl-coa acetyltransferase BF27_2484 ENOG4105C1G acyl-Coa dehydrogenase BF27_2485 ENOG4108W8B Beta-lactamase domain protein BF27_2491 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF27_2500 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF27_2506 ENOG4108UMI ABC transporter, permease BF27_2507 ENOG4105D01 (LipO)protein BF27_2508 ENOG4105D01 (LipO)protein BF27_2509 ENOG4105C3K feS assembly ATPase SufC BF27_2510 ENOG4105JRK feS assembly protein SufD BF27_2511 ENOG4105C9B Cysteine desulfurase BF27_2512 ENOG4108UNV SUF system FeS assembly protein, NifU family BF27_2513 ENOG4105DIW FeS assembly protein SUFB BF27_2516 ENOG4107R8B 5'-nucleotidase BF27_2517 ENOG4105KZD Domain of unknown function (DUF1805) BF27_2519 ENOG4105FAA peptidase M23 BF27_2524 ENOG41090T1 Membrane BF27_2525 ENOG4107TXC Transcriptional regulator BF27_2526 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF27_2527 ENOG4105MMD transcriptional regulator BF27_2530 ENOG4105CBT Fructose-1,6-bisphosphatase BF27_2533 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF27_2534 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF27_2536 ENOG4108W5N phosphatidylglycerophosphatase a BF27_2539 ENOG41083MR nifu domain-containing protein BF27_2548 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF27_2549 ENOG4105C4B ABC transporter, permease BF27_2550 ENOG4108JJA ABC, transporter BF27_2554 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF27_2557 ENOG4105EWC Purine nucleoside phosphorylase BF27_2563 ENOG4105CEP NADH dehydrogenase BF27_2566 ENOG41069ER domain protein BF27_2570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF27_2574 ENOG4105KA0 thioesterase Superfamily protein BF27_2575 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF27_2578 ENOG4107R3E Citrate transporter BF27_2580 ENOG4105Y38 Kinase-associated protein B BF27_2583 ENOG4105C87 Aminotransferase class I and II BF27_2585 ENOG4108MUZ hydrolase BF27_2586 ENOG4105C5I Dehydrogenase BF27_2587 ENOG4108ZB6 transcriptional regulator AsnC family BF27_2588 ENOG4105CHM Aminotransferase BF27_2590 ENOG4105WG9 Conserved Protein BF27_2591 ENOG4107QYV phosphohexose isomerase BF27_2592 ENOG4107PBV potassium channel BF27_2594 ENOG4105KT7 mgtC SapB transporter BF27_26 ENOG4105C6X Major Facilitator BF27_260 ENOG4105XSJ toxin secretion phage lysis holin BF27_2602 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF27_2620 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF27_2622 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF27_2624 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF27_2629 ENOG4105VEQ Cold shock protein BF27_2631 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF27_2632 ENOG4105E4F Isochorismate synthase BF27_2633 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF27_2634 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF27_2635 ENOG4108IPT Naphthoate synthase BF27_2637 ENOG4105DTQ mandelate racemase muconate lactonizing BF27_2644 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF27_2648 ENOG4105FDP GntR family transcriptional regulator BF27_2649 ENOG4105C6Z Gluconate BF27_2657 ENOG41086D8 Transcriptional regulator BF27_2658 ENOG4105C19 ABC transporter BF27_2661 ENOG4107ZTW SNARE associated Golgi BF27_2668 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF27_2669 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF27_2674 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_2675 ENOG4105BZU Histidine kinase BF27_2682 ENOG41087YS Phage shock protein A BF27_2691 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF27_2692 ENOG4105C4M (Ubiquinol oxidase) subunit I BF27_2694 ENOG4108V2W Carbonate dehydratase BF27_2701 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF27_2705 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF27_2707 ENOG4105D2X ABC transporter substrate-binding protein BF27_2710 ENOG4107T7U Sulfatase BF27_2711 ENOG4107S9D Alpha beta hydrolase BF27_2712 ENOG4105BZU Histidine kinase BF27_2713 ENOG4105BZU Histidine kinase BF27_2714 ENOG4105EGD dinuclear metal center protein, YbgI family BF27_2724 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF27_2726 ENOG4105BZF Glycosyl transferase (Group 1 BF27_2727 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF27_2728 ENOG4108Z0R Transferase BF27_2729 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF27_2735 ENOG4105DA5 (ABC) transporter BF27_2737 ENOG4105N5T Radical SAM Protein BF27_2741 ENOG4105C19 ABC transporter BF27_2744 ENOG4105NCW Trka-c domain protein BF27_2745 ENOG4107S91 Sodium hydrogen exchanger BF27_2746 ENOG410605W Major Facilitator BF27_2752 ENOG4108B31 Spore germination protein BF27_2754 ENOG4105DWV Homoserine O-trans-acetylase BF27_2756 ENOG41085GJ domain protein BF27_276 ENOG4105CAR Terminase, large subunit BF27_2760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF27_2761 ENOG4105D06 uba thif-type nad fad binding protein BF27_2763 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF27_2764 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF27_2765 ENOG4108ZAF Molybdopterin BF27_2769 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF27_2770 ENOG4108VJ1 Transcriptional regulator (CarD family BF27_2778 ENOG4105CBX hi0933 family BF27_2781 ENOG4105YW5 deoR family transcriptional regulator BF27_2782 ENOG4107QSE Dipeptidase BF27_2784 ENOG4108IUM Glycogen debranching enzyme BF27_2785 ENOG4108V15 phosphotransferase enzyme family BF27_2788 ENOG4105C8F Beta-lactamase domain protein BF27_2794 ENOG4108VDD TRNA binding domain protein BF27_2803 ENOG4105C88 aminopeptidase BF27_2807 ENOG4105ETE Transcriptional regulator (LacI family BF27_2813 ENOG4105EP9 oxidoreductase BF27_2814 ENOG4107SNB ankyrin repeat protein YahD BF27_2816 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_2818 ENOG4105DGU Histone deacetylase BF27_2819 ENOG4105W87 Cbs domain BF27_2820 ENOG4105F1V Acetoin utilization protein BF27_2823 ENOG4105EMN RNA polymerase sigma factor BF27_2825 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF27_2829 ENOG4105C28 cystathionine BF27_2831 ENOG4105U5Y Transcriptional regulator BF27_2833 ENOG4106KR7 LysR family Transcriptional regulator BF27_2838 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF27_2840 ENOG4105EFZ amidohydrolase BF27_2843 ENOG4105KBJ sporulation protein ytfj BF27_2844 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF27_2846 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF27_2850 ENOG4108JYZ YitT family BF27_2859 ENOG4107YZX Universal stress protein BF27_2863 ENOG4105VZ8 Transcriptional regulator BF27_2865 ENOG41082W1 Cupin 2, conserved barrel domain protein BF27_2866 ENOG4105Z7P Acetyltransferase (GNAT) family BF27_2873 ENOG4105DC7 peptidase M24 BF27_2880 ENOG4105SFS phosphoesterase RecJ domain protein BF27_2882 ENOG4105VV2 BF27_2883 ENOG4105C0B DNA polymerase III (alpha subunit) BF27_2884 ENOG4105C6K Malic enzyme BF27_2885 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF27_2890 ENOG4105FS0 cytoplasmic membrane protein BF27_2891 ENOG4108REF Sporulation integral membrane protein ytvi BF27_2893 ENOG4105BZN citrate synthase BF27_2894 ENOG4108HMX isocitrate dehydrogenase (NADP) BF27_2898 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_2899 ENOG4105BZU Histidine kinase BF27_2900 ENOG4105C2M dna polymerase I BF27_2901 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF27_2903 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF27_2904 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF27_2905 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF27_2909 ENOG4108TDW sporulation protein YtxC BF27_2910 ENOG4105C22 threonyL-tRNA synthetase BF27_2911 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF27_2915 ENOG4105CN9 Peptidase m42 family protein BF27_2916 ENOG4108JGH Tetr family transcriptional regulator BF27_2917 ENOG4105CW7 secretion protein, HlyD family BF27_2918 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_292 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BF27_2925 ENOG4108RWN rrna methyltransferase BF27_2927 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF27_2928 ENOG4105C5S asparaginyl-tRNA synthetase BF27_2935 ENOG4105DCG PHP domain protein BF27_2938 ENOG4105FE9 pseudouridine synthase BF27_2940 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF27_2942 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF27_2945 ENOG4105E0A ABC, transporter BF27_2946 ENOG4105KFN sortase, SrtB family BF27_2949 ENOG4105DR4 Methyltransferase BF27_2952 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_296 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_2961 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF27_2962 ENOG4105J76 Periplasmic binding protein BF27_2964 ENOG4105CEY Amp-dependent synthetase and ligase BF27_2965 ENOG4107Z3H Transcriptional regulator, TetR family BF27_2966 ENOG41060WC Enoyl-CoA hydratase BF27_2967 ENOG4105BZJ Electron transfer flavoprotein BF27_2968 ENOG4105C10 Electron transfer flavoprotein BF27_2969 ENOG4105K63 Thioredoxin BF27_2972 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF27_2974 ENOG4105E33 succinate dehydrogenase BF27_2976 ENOG4108VXD carboxy-peptidase BF27_2977 ENOG4105E14 MotA TolQ exbB proton channel BF27_2978 ENOG4105ER2 Ompa motb domain protein BF27_2979 ENOG4105ER2 Ompa motb domain protein BF27_2980 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF27_2981 ENOG4108IUX (ABC) transporter BF27_2982 ENOG4105RHA ABC transporter, permease BF27_2983 ENOG4108Z40 Transcriptional regulator BF27_2984 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF27_2986 ENOG4108JCI Transcriptional regulator BF27_2987 ENOG41067S9 phage shock protein C, PspC BF27_2989 ENOG4105DY9 regulatoR BF27_2990 ENOG4108HRK Histidine kinase BF27_2991 ENOG4108JQ7 (ABC) transporter BF27_2994 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF27_2995 ENOG4105DEF Extracellular solute-binding protein, family 5 BF27_2996 ENOG4105DZC cytosine deaminase BF27_2997 ENOG4105DZC cytosine deaminase BF27_30 ENOG4105PNM synthesis protein BF27_3000 ENOG4105PFC Transcriptional regulator BF27_3003 ENOG4105KBX Transcriptional regulator, TetR family BF27_3005 ENOG4108PCX Major Facilitator BF27_3007 ENOG4108XJQ germination protein BF27_3009 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF27_3010 ENOG4105M59 Phosphodiesterase, mj0936 family BF27_3014 ENOG4108QCI YvbH-like oligomerisation region BF27_3020 ENOG4108IUQ atp-dependent protease BF27_3024 ENOG4105K56 Transcriptional regulator BF27_3029 ENOG4105D52 delta-aminolevulinic acid dehydratase BF27_3031 ENOG41068KH stage VI sporulation protein D BF27_3033 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF27_3034 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF27_3038 ENOG4105DFF Rod shape-determining protein mreb BF27_3039 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF27_3042 ENOG4107QMS site-determining protein BF27_3045 ENOG4105C03 ribonuclease BF27_3047 ENOG4105X36 (ribosomal) protein BF27_305 ENOG4105CFF transcriptional regulator BF27_3053 ENOG4105EWM Histidine kinase BF27_3057 ENOG4105CQC Prephenate dehydratase BF27_3058 ENOG4108RPX mosc domain containing protein BF27_3061 ENOG4108IYU L-aspartate oxidase BF27_3062 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF27_3067 ENOG41082BM Transcriptional regulator, arsr family BF27_3068 ENOG4108IPJ Membrane BF27_3069 ENOG4108IPJ Membrane BF27_3071 ENOG4108HUF Transporter BF27_3074 ENOG41061AI Protein of unknown function (DUF2905) BF27_3077 ENOG4105VIE preprotein translocase, subunit YajC BF27_3079 ENOG4108QG2 Membrane BF27_3080 ENOG4105CKP Polysaccharide Biosynthesis Protein BF27_3082 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF27_3083 ENOG41076HS cation diffusion facilitator family transporter BF27_3084 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF27_3086 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF27_3089 ENOG4105CUT histidyl-tRNA synthetase BF27_3091 ENOG4105CUZ uba thif-type nad fad binding protein BF27_3092 ENOG4108VCI transcription factor, rsfa family BF27_3093 ENOG4105D1H recombination factor protein RarA BF27_3095 ENOG4105C3J Cysteine desulfurase BF27_3098 ENOG4105C7H Helicase, RecD TraA family BF27_3099 ENOG41060CR BF27_3102 ENOG4105C02 permease BF27_3104 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF27_3108 ENOG4105HHA aminodeoxychorismate lyase BF27_3109 ENOG4108VQJ O-methyltransferase BF27_3110 ENOG4105XYU peptidase (U32 family) BF27_3111 ENOG4105CFP Peptidase U32 BF27_3114 ENOG4107XRG penicillin-binding protein BF27_3120 ENOG4105C28 cystathionine BF27_3121 ENOG4108EKI Dehydrogenase BF27_3123 ENOG4108V5C ABC transporter BF27_3124 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF27_3132 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_3134 ENOG4105MIR Phenylalanine 4-monooxygenase BF27_3135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF27_3142 ENOG4108MUZ hydrolase BF27_3144 ENOG4105G6Z alkaline phosphatase BF27_3149 ENOG4108TVJ Nitroreductase BF27_3153 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_3155 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF27_3156 ENOG4105CQW ribosome biogenesis GTPase YqeH BF27_3158 ENOG410812S Rna-binding protein BF27_3160 ENOG4108WF2 Metal Dependent Phosphohydrolase BF27_3162 ENOG4105DXX methyltransferase BF27_3164 ENOG4105KQC Competence protein BF27_3165 ENOG4108UK2 deaminase BF27_3166 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF27_3168 ENOG4105TQK DNA polymerase iii, delta' subunit BF27_3173 ENOG4105KVH Transcriptional regulator BF27_3174 ENOG4105CSA Coproporphyrinogen iii oxidase BF27_3176 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF27_3180 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF27_3181 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF27_3183 ENOG4105KTH gatB Yqey BF27_3184 ENOG41068P3 sporulation protein YqfC BF27_3186 ENOG4105C9A Phoh family BF27_3187 ENOG4105CTJ Metal Dependent Phosphohydrolase BF27_3189 ENOG4107YR5 Diacylglycerol kinase BF27_3190 ENOG4105KG3 cytidine deaminase BF27_3191 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF27_3196 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF27_3197 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_32 ENOG4105C7B Threonine dehydratase BF27_320 ENOG4105XSJ toxin secretion phage lysis holin BF27_3200 ENOG4105EGD dinuclear metal center protein, YbgI family BF27_3205 ENOG41069ZM Protein of unknown function (DUF2624) BF27_3206 ENOG4108JYZ YitT family BF27_3207 ENOG4105FDK ABC transporter BF27_3209 ENOG4105N80 Ferric uptake regulator, Fur family BF27_3214 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF27_3216 ENOG4107RF6 penicillin-binding protein BF27_3217 ENOG4105PWN phosphate abc transporter BF27_3218 ENOG4105C8U phosphate abc transporter BF27_3219 ENOG4105E2Z phosphate ABC transporter (Permease BF27_3220 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF27_3221 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF27_3224 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF27_3229 ENOG4105C5X domain protein BF27_3233 ENOG4105C28 cystathionine BF27_3234 ENOG4105C28 cystathionine BF27_3236 ENOG4105C3R Methionine synthase BF27_3237 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF27_3261 ENOG4105C0D helicase BF27_3267 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF27_3268 ENOG4105CJ1 ABC, transporter BF27_3275 ENOG41080TC multidrug resistance protein BF27_3279 ENOG4105WZW rhodanese family BF27_3280 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF27_3285 ENOG4107YBY Hydrolase BF27_3286 ENOG4105CBJ Metal-dependent enzyme BF27_3289 ENOG4105DC7 peptidase M24 BF27_3294 ENOG4105CD2 stage iii sporulation protein aa BF27_3295 ENOG4105KR5 Stage iii sporulation protein BF27_3296 ENOG4108CQH stage III sporulation protein AC BF27_3297 ENOG4105KQ4 Stage iii sporulation protein ad BF27_3299 ENOG410644B Stage III sporulation protein af BF27_3304 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF27_3305 ENOG4108ZSR alkaline shock protein BF27_3310 ENOG4105CTB Polyprenyl synthetase BF27_3312 ENOG4105DX0 Hemolysin A BF27_3314 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF27_3315 ENOG4105S1Z Stage IV sporulation protein B BF27_3316 ENOG4107QQR Sporulation BF27_3319 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF27_3321 ENOG4108JUB Transcriptional regulator BF27_3323 ENOG4107RDP Dehydrogenase BF27_3327 ENOG4105CPP Dehydrogenase, E1 component BF27_3328 ENOG4105C7S Dehydrogenase BF27_3330 ENOG4105E09 nadh pyrophosphatase BF27_3331 ENOG4105G7B Protein of unknown function (DUF2992) BF27_3333 ENOG4108HW3 (ABC) transporter BF27_3334 ENOG4105E5Q amino acid AbC transporter BF27_3335 ENOG4105CDA abc transporter atp-binding protein BF27_3336 ENOG4108QEG Membrane BF27_3337 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF27_3339 ENOG4105D9U N-acetyltransferase BF27_3340 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF27_3342 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF27_3346 ENOG4105EJQ L-serine dehydratase BF27_3347 ENOG4105II7 pyrroline-5-carboxylate reductase BF27_3348 ENOG41069FQ Metallo-beta-lactamase superfamily BF27_3349 ENOG4108IXY short-chain dehydrogenase reductase BF27_335 ENOG4105CAR Terminase, large subunit BF27_3352 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF27_3360 ENOG4105CGH 5'-nucleotidase BF27_3361 ENOG4105DFD Na H antiporter BF27_3363 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF27_3365 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF27_3366 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF27_3367 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF27_3368 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF27_3372 ENOG4108R6K riboflavin synthase, subunit alpha BF27_3373 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF27_3377 ENOG4108YM7 Gcn5-related n-acetyltransferase BF27_3378 ENOG4105ETE Transcriptional regulator (LacI family BF27_3380 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF27_3384 ENOG4105RHY Pfam:UPF0157 BF27_3386 ENOG4105CPC Aldo Keto reductase BF27_3390 ENOG4105MZ9 stage II sporulation protein m BF27_3391 ENOG4105I3K Ferric uptake regulator, Fur family BF27_3393 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF27_3398 ENOG4105D7N magnesium and cobalt transport protein CorA BF27_34 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF27_3404 ENOG4105DVE abc transporter atp-binding protein BF27_3405 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF27_3406 ENOG4105DZ1 carboxypeptidase BF27_3407 ENOG41082AN stage II sporulation protein BF27_3409 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_3410 ENOG4105C8J )-transporter BF27_3414 ENOG41090VF Stage v sporulation protein ac BF27_3415 ENOG4105CZ3 stage V sporulation protein ad BF27_3417 ENOG4105G6R Stage v sporulation protein ae BF27_3419 ENOG4105J7I hydrolase BF27_3420 ENOG4105PTM secreted protein BF27_3421 ENOG4107ZE5 PPIases accelerate the folding of proteins BF27_3428 ENOG4105CE4 GlcNAc 6-P deacetylase BF27_3430 ENOG4105FDP GntR family transcriptional regulator BF27_3432 ENOG4105CID antiterminator BF27_3435 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF27_3439 ENOG4106TD9 Diguanylate cyclase BF27_3449 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF27_3451 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF27_3453 ENOG4105DTD Dehydrogenase BF27_3454 ENOG4105K7K Transcriptional regulator BF27_3461 ENOG4105CHU acetyl-coa acetyltransferase BF27_3470 ENOG4105CG3 alpha amylase, catalytic region BF27_3472 ENOG4107FKK extracellular solute-binding protein family 1 BF27_3474 ENOG4105EG2 ABC transporter, permease BF27_3475 ENOG4105FKQ transcriptional regulator BF27_3476 ENOG4105CHM Aminotransferase BF27_3478 ENOG4108HGU Histidine kinase BF27_3489 ENOG4105UIN BF27_3491 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF27_3494 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF27_3495 ENOG4105EPM Diguanylate phosphodiesterase BF27_3498 ENOG4107IN1 Protein of unknown function (DUF1797) BF27_35 ENOG4108ZP8 Acetolactate synthase small subunit BF27_3500 ENOG4108XRC Protein of unknown function (DUF458) BF27_3507 ENOG4107ZYR domain protein BF27_3508 ENOG4105CN5 Metallo-Beta-Lactamase BF27_351 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BF27_3510 ENOG4108X4Q Hydrolase BF27_3511 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF27_3514 ENOG4105CPP Dehydrogenase, E1 component BF27_3524 ENOG4105CXN decarboxylase BF27_3528 ENOG4105ECY inositol monophosphatase BF27_3530 ENOG4105CI3 gtp-binding protein typa BF27_3531 ENOG4105QA2 BF27_3535 ENOG4108IAB Phoh family BF27_3538 ENOG4105CNI cell division protein FtsW BF27_3539 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF27_3549 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF27_355 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_3552 ENOG4107TB6 phosphoglycerate mutase BF27_3557 ENOG4106H78 methyltransferase BF27_3558 ENOG4105H20 Sporulation integral membrane protein YlbJ BF27_3560 ENOG4105D78 K07001 NTE family protein BF27_3561 ENOG41063PX domain protein BF27_3563 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF27_3570 ENOG4108IMY Transcriptional regulator BF27_3581 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_3584 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF27_36 ENOG4105C7K acetolactate synthase BF27_3601 ENOG4105CAR Terminase, large subunit BF27_3603 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF27_3618 ENOG4105XSJ toxin secretion phage lysis holin BF27_3628 ENOG4105KNH Nucleic acid-binding protein BF27_3635 ENOG41068DC Essential cell division protein (By similarity) BF27_3636 ENOG4105CJN penicillin-binding protein BF27_3637 ENOG4105CJN penicillin-binding protein BF27_3638 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF27_364 ENOG4105CFF transcriptional regulator BF27_3641 ENOG4105CNI cell division protein FtsW BF27_3642 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF27_3643 ENOG4105D4A Cell wall formation (By similarity) BF27_3644 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF27_3645 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF27_3646 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF27_3648 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_3650 ENOG4105WR5 sporulation protein, YlmC YmxH family BF27_3651 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF27_3652 ENOG4105DFA alanine racemase domain protein BF27_3654 ENOG41067XK integral membrane protein BF27_3655 ENOG4105DBK s4 domain protein BF27_3657 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF27_3660 ENOG4105C34 Pseudouridine synthase BF27_3665 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF27_3676 ENOG4105DC7 peptidase M24 BF27_3677 ENOG4105F23 Fibronectin-binding protein BF27_3679 ENOG4105DSJ YicC domain protein BF27_3683 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF27_3684 ENOG4105C25 Primosomal protein n' BF27_3685 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF27_3687 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF27_3689 ENOG4108ZF3 Phosphatase BF27_369 ENOG4105CPK Glycosyl transferase (Group 1 BF27_3690 ENOG4105D9P serine threonine protein kinase BF27_3691 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF27_3692 ENOG4105DJV ribulose-phosphate 3-epimerase BF27_3693 ENOG4105FJ0 thiamine BF27_3695 ENOG4108ZAA Alkaline-shock protein BF27_3696 ENOG4105DP4 dak2 domain fusion protein ylov BF27_3697 ENOG4105CB5 ATP-dependent DNA helicase recG BF27_37 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF27_3700 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF27_3701 ENOG4105CHR reductase BF27_3704 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF27_3705 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF27_3709 ENOG4105VB6 UPF0109 protein BF27_3714 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF27_3717 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF27_3718 ENOG4105C79 DNA protecting protein DprA BF27_3719 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF27_3721 ENOG4108HE4 integrase family BF27_3730 ENOG4105KNE Phosphatidate cytidylyltransferase BF27_3731 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF27_3732 ENOG4105DZP Membrane-associated zinc metalloprotease BF27_3734 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF27_3736 ENOG4105CHV Transcription elongation factor NusA BF27_3737 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF27_3738 ENOG4105VHM ribosomal protein BF27_3740 ENOG4105W7A Protein of unknown function (DUF503) BF27_3742 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF27_3743 ENOG4105DTN riboflavin biosynthesis protein ribF BF27_3747 ENOG4105C1V Peptidase, M16 BF27_3749 ENOG4105E35 Dipicolinate synthase subunit A BF27_3750 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF27_3751 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF27_3753 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF27_3755 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF27_3757 ENOG4107QZI cell division protein FtsK BF27_3758 ENOG4105FDP GntR family transcriptional regulator BF27_3759 ENOG4105DIH basic membrane BF27_3760 ENOG4108JQ9 ABC transporter BF27_3761 ENOG4105UIB (ABC) transporter BF27_3762 ENOG4105UIB (ABC) transporter BF27_3766 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF27_3767 ENOG4105XZV Protein of unknown function (DUF3243) BF27_3770 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF27_3775 ENOG4105D48 metallophosphoesterase BF27_3776 ENOG4105MCT stage V sporulation protein S BF27_3777 ENOG4108IGT Dipeptidase BF27_3778 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF27_3779 ENOG4105DQU oxidoreductase, subunit beta BF27_3780 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF27_3785 ENOG4105DA5 (ABC) transporter BF27_3790 ENOG4107QHE Choloylglycine hydrolase BF27_3792 ENOG410890F Dynamin family BF27_3793 ENOG4105E0M Sulfatase BF27_3794 ENOG4107R6R udp-galactopyranose mutase BF27_3795 ENOG4105F0V Cell wall hydrolase BF27_3799 ENOG4107YEI lmbE family BF27_38 ENOG4105CHR reductase BF27_380 ENOG4106032 Glutathionylspermidine synthase BF27_3800 ENOG4107TTQ Alpha beta hydrolase fold BF27_3803 ENOG41067MG lrgb family BF27_3806 ENOG4105BZU Histidine kinase BF27_3807 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_3813 ENOG4105D03 DNA-3-methyladenine glycosylase II BF27_3814 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF27_3816 ENOG4105CGK Exodeoxyribonuclease III BF27_3821 ENOG4105E0A ABC, transporter BF27_3822 ENOG4105NIV Esterase BF27_3824 ENOG4105VPX protein, conserved in bacteria BF27_3825 ENOG410681U heavy metal transport detoxification protein BF27_3826 ENOG4105C59 p-type ATPase BF27_3827 ENOG4105K70 DNA-binding protein BF27_3828 ENOG4105TMB Formate nitrite transporter BF27_383 ENOG4105KHC sulfurtransferase BF27_3832 ENOG4105C85 amino acid BF27_3835 ENOG4108SJC Membrane BF27_3836 ENOG4107QW4 alcohol dehydrogenase BF27_3837 ENOG4107QW4 alcohol dehydrogenase BF27_3838 ENOG4105E98 transcriptional regulator DeoR family BF27_3839 ENOG4105DE4 1-phosphofructokinase BF27_3842 ENOG41069ER domain protein BF27_3848 ENOG4106F1P AAA ATPase, central domain protein BF27_385 ENOG4108W0I acetyltransferase BF27_3850 ENOG4105EN6 Membrane BF27_3851 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF27_3852 ENOG4105CXI aluminum resistance protein BF27_3853 ENOG4105KV4 Transcriptional regulator BF27_3854 ENOG4105C5F glutamine synthetase BF27_387 ENOG410890F Dynamin family BF27_3874 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF27_389 ENOG4105DHF Membrane BF27_39 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF27_390 ENOG4105C2W permease BF27_3912 ENOG4105XSJ toxin secretion phage lysis holin BF27_3913 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF27_392 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF27_3921 ENOG4105K7K Transcriptional regulator BF27_3925 ENOG4108SVB resolvase BF27_3927 ENOG4105CGH 5'-nucleotidase BF27_3930 ENOG4105D5T phosphonate abc transporter BF27_3933 ENOG4105D7V transposase BF27_3937 ENOG4105BZ1 (ABC) transporter BF27_3938 ENOG4105BZ1 (ABC) transporter BF27_3941 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF27_3946 ENOG41067MG lrgb family BF27_3948 ENOG4107RSM transcriptional regulator BF27_395 ENOG4105CTD carboxy-peptidase BF27_3950 ENOG4105CJ1 ABC, transporter BF27_3952 ENOG4105CH2 amidohydrolase BF27_3954 ENOG4107QIV Cytochrome c biogenesis protein BF27_396 ENOG4105DVT helicase BF27_3962 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF27_3967 ENOG4108903 Formimidoylglutamase BF27_3968 ENOG4108VJ1 Transcriptional regulator (CarD family BF27_3969 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF27_3970 ENOG4105CBC glutamate synthase BF27_3971 ENOG4105CK7 Sodium proline symporter BF27_3972 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF27_3973 ENOG4105FBA Phospholipase Carboxylesterase BF27_3974 ENOG4105BZU Histidine kinase BF27_3976 ENOG4107AYK membrAne BF27_398 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF27_3985 ENOG4105CEY Amp-dependent synthetase and ligase BF27_3986 ENOG4107ZYJ bioY protein BF27_3987 ENOG4107F3J Amp-dependent synthetase and ligase BF27_3991 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF27_3993 ENOG4105E5W Transporter BF27_3999 ENOG4108I0Z Aconitate hydratase BF27_4 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF27_4000 ENOG4108JJA ABC, transporter BF27_4002 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF27_4003 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF27_4009 ENOG4105W8X HesB YadR YfhF-family protein BF27_4010 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF27_4011 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF27_4013 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_4014 ENOG4105C0H protease BF27_4015 ENOG4105K4P CoA-binding domain protein BF27_4016 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF27_4018 ENOG4105D9R oxidoreductase BF27_4020 ENOG4105CIG ABC transporter BF27_4023 ENOG4105EMN RNA polymerase sigma factor BF27_4025 ENOG4108KGH TRANSCRIPTIONal BF27_4026 ENOG4107QJT sodium dicarboxylate symporter BF27_4038 ENOG4105E1K spore germination protein BF27_4040 ENOG4108JB9 formate dehydrogenase BF27_4042 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF27_4043 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF27_4045 ENOG4105TMB Formate nitrite transporter BF27_4046 ENOG4105D06 uba thif-type nad fad binding protein BF27_4047 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF27_4048 ENOG4108ZAF Molybdopterin BF27_4050 ENOG4105D1F ATP-binding protein BF27_4053 ENOG410696E Membrane BF27_4054 ENOG4105FR1 rard protein BF27_4056 ENOG4105EWU Squalene--hopene cyclase BF27_4058 ENOG4105CHR reductase BF27_4059 ENOG4105C26 Dehydrogenase BF27_4061 ENOG4108IA2 Sodium pantothenate symporter BF27_4064 ENOG4106IQC argininosuccinate lyase BF27_4066 ENOG410904N short-chain dehydrogenase reductase BF27_4072 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF27_4076 ENOG4105VEQ Cold shock protein BF27_4080 ENOG4108R1P BF27_4082 ENOG41073R8 VanW family BF27_4083 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_4085 ENOG4105KT7 mgtC SapB transporter BF27_4087 ENOG4105E39 Enoyl-CoA hydratase BF27_4088 ENOG4105K64 Glycosyl transferase, family 2 BF27_409 ENOG4105BZ4 penicillin-binding protein BF27_4090 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF27_4094 ENOG4105CQB FAD linked oxidase domain protein BF27_4095 ENOG4105C09 Bile acid BF27_4097 ENOG4105RHY Pfam:UPF0157 BF27_4102 ENOG4105CIS alcohol dehydrogenase BF27_4103 ENOG41082BM Transcriptional regulator, arsr family BF27_4107 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF27_411 ENOG4105CSM endonuclease III BF27_4113 ENOG4108A04 Beta-lactamase BF27_4114 ENOG4105DPN Oligoendopeptidase f BF27_4115 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF27_4116 ENOG4105E5K Alpha-amylase BF27_4118 ENOG4105C98 muts2 protein BF27_4122 ENOG4107V2S Transcriptional regulator BF27_4124 ENOG4107CUJ Protein of unknown function (DUF2690) BF27_4128 ENOG4107ZY0 Phenazine biosynthesis-like protein BF27_4129 ENOG4105NX3 Membrane BF27_4130 ENOG4105DQ5 transport system permease protein BF27_4131 ENOG4105EHG Permease protein BF27_4132 ENOG4108MES Periplasmic binding protein BF27_4136 ENOG4107R3E Citrate transporter BF27_4138 ENOG4108TN2 lmbE family BF27_4145 ENOG4105CIS alcohol dehydrogenase BF27_415 ENOG4105YAC BF27_4152 ENOG4105H3G oxidoreductase BF27_4154 ENOG4105ED2 Beta-lactamase BF27_4159 ENOG4107YXZ hydrolase, family 25 BF27_416 ENOG4105DVT helicase BF27_4163 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF27_4168 ENOG4105KAF membrAne BF27_4178 ENOG4108ZJ4 polysaccharide deacetylase BF27_4182 ENOG4105KVH Transcriptional regulator BF27_4183 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF27_4188 ENOG4105CHR reductase BF27_4190 ENOG4105JAB phenazine biosynthesis protein, phzf family BF27_4197 ENOG4105KVH Transcriptional regulator BF27_4198 ENOG4105KVH Transcriptional regulator BF27_4199 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF27_4200 ENOG4105D9R oxidoreductase BF27_4201 ENOG4108TZY GntR Family Transcriptional Regulator BF27_4202 ENOG4105KVH Transcriptional regulator BF27_4208 ENOG4105C44 Serine transporter BF27_4209 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF27_4212 ENOG4105F27 Major Facilitator BF27_4213 ENOG4105CV8 reductase BF27_4217 ENOG4105D4Y metalloprotease BF27_4218 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF27_4221 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF27_4222 ENOG4105CIS alcohol dehydrogenase BF27_4223 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF27_4224 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF27_4227 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF27_4228 ENOG4105C6Z Gluconate BF27_4229 ENOG4105CMG Carbohydrate kinase BF27_423 ENOG4105CPK Glycosyl transferase (Group 1 BF27_4230 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF27_4231 ENOG4105XDF Protein of unknown function (DUF1272) BF27_4232 ENOG4105DDN Pentapeptide repeat-containing protein BF27_4235 ENOG4105C37 (CBS) domain BF27_424 ENOG4105FJR Lmbe family BF27_4241 ENOG4105EV4 Multidrug resistance protein mdtH BF27_4243 ENOG4105DMQ Methyltransferase BF27_4249 ENOG4105C31 Tryptophanyl-tRNA synthetase BF27_4251 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF27_4253 ENOG4108UW5 maltose o-acetyltransferase BF27_4254 ENOG4106UW1 Major Facilitator superfamily BF27_4255 ENOG4105DKQ ROK family BF27_4256 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_4268 ENOG4105CJ1 ABC, transporter BF27_427 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF27_4270 ENOG4108PSK reductase BF27_4274 ENOG4108RCM Nitroreductase BF27_4275 ENOG4105KVH Transcriptional regulator BF27_4278 ENOG4105CUT histidyl-tRNA synthetase BF27_4279 ENOG4108Z66 YbaK ebsC protein BF27_428 ENOG4108JYZ YitT family BF27_4281 ENOG41067QW Transcriptional regulator BF27_4284 ENOG4108K8S endonuclease I BF27_4289 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF27_4290 ENOG4108JJB ABC transporter BF27_4296 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF27_4298 ENOG4105CRW Short chain fatty acid transporter BF27_43 ENOG4106KE4 Dehydrogenase BF27_4300 ENOG4105KBX Transcriptional regulator, TetR family BF27_4301 ENOG4105KPY Small multidrug resistance protein BF27_4302 ENOG4105RXJ BF27_4304 ENOG41069JR BF27_4310 ENOG4105CZM Major Facilitator BF27_4311 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF27_4313 ENOG4108ISG Major Facilitator BF27_4320 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF27_4323 ENOG410874W AraC family transcriptional regulator BF27_4324 ENOG41082W1 Cupin 2, conserved barrel domain protein BF27_4327 ENOG4108AEY RNA polymerase sigma factor BF27_4331 ENOG4108JQ1 Dehydrogenase BF27_4334 ENOG4105DVH amino acid BF27_4336 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF27_4339 ENOG4108JPW Aminotransferase BF27_434 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF27_4341 ENOG4105EJQ L-serine dehydratase BF27_4342 ENOG4105C44 Serine transporter BF27_4345 ENOG4108JGH Tetr family transcriptional regulator BF27_4346 ENOG4105EQ0 Major Facilitator superfamily BF27_4347 ENOG4105MZU cell filamentation protein BF27_435 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF27_4350 ENOG4107QJQ Mate efflux family protein BF27_4357 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF27_436 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF27_4364 ENOG4105TRI Hydrolase BF27_4370 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF27_4372 ENOG4106P55 Transcriptional regulator BF27_4374 ENOG4107QR9 Iron-sulfur cluster binding protein BF27_4375 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF27_4376 ENOG4105DJB Major Facilitator Superfamily BF27_4377 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF27_4379 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF27_4380 ENOG4108U05 Transcriptional regulator BF27_4383 ENOG4105BZU Histidine kinase BF27_4386 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF27_4387 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF27_439 ENOG41068YB TPR repeat-containing protein BF27_4390 ENOG4105JQZ Methyltransferase BF27_4391 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF27_4393 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF27_4394 ENOG4108NNI Beta-lactamase domain-containing protein BF27_4397 ENOG4105VZ8 Transcriptional regulator BF27_440 ENOG4105CIH Imidazole acetol-phosphate transaminase BF27_4402 ENOG4105K6H D-cysteine desulfhydrase BF27_4407 ENOG41062D9 Histidine kinase BF27_4408 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_4411 ENOG4105IIP Membrane BF27_4413 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_4414 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF27_4427 ENOG4108YXU transcriptional regulator AsnC family BF27_4428 ENOG4105CHR reductase BF27_4430 ENOG4105F7F Chaperone BF27_4434 ENOG41085FC arsR family transcriptional regulator BF27_4435 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_4436 ENOG4105D6J arsenicaL-resistance protein BF27_444 ENOG4105EAH synthase BF27_4442 ENOG4105DIK (ABC) transporter BF27_4443 ENOG4105CC5 ABC transporter BF27_4444 ENOG4105DSE periplasmic solute binding protein BF27_4445 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF27_4446 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF27_4448 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF27_4449 ENOG4108TWJ NADH dehydrogenase subunit 5 BF27_4452 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF27_4453 ENOG4108606 TspO/MBR family BF27_446 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF27_4460 ENOG41090MY MarR family Transcriptional regulator BF27_4465 ENOG4105CHJ isochorismatase hydrolase BF27_4467 ENOG4105CH6 catalase BF27_4468 ENOG4105CGH 5'-nucleotidase BF27_4476 ENOG4105CSV Glutaminase BF27_4480 ENOG4108Q8B Spore germination protein BF27_4481 ENOG4108NHD germination protein BF27_4483 ENOG4105C6K Malic enzyme BF27_4485 ENOG4105II7 pyrroline-5-carboxylate reductase BF27_4489 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF27_449 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF27_4491 ENOG4108IMY Transcriptional regulator BF27_4492 ENOG4105HDK L-asparaginase BF27_4493 ENOG4108IJ0 Aspartate ammonia-lyase BF27_4496 ENOG4105E2A Dehydrogenase BF27_4511 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF27_4517 ENOG4105DWD nucleoside recognition domain protein BF27_4521 ENOG4105FDT acyl-CoA dehydrogenase BF27_4523 ENOG4108ZHR arsR family transcriptional regulator BF27_4524 ENOG4108ZRV stage ii sporulation protein p BF27_4525 ENOG4106N3A copper homeostasis protein cutc BF27_4527 ENOG4107258 Transcriptional regulator BF27_4528 ENOG4105P4J Allophanate hydrolase, subunit 1 BF27_4535 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF27_4538 ENOG4107RF6 penicillin-binding protein BF27_4546 ENOG4105F1N DNA alkylation repair BF27_4548 ENOG4108IQI permease BF27_4549 ENOG4105KNA -acetyltransferase BF27_455 ENOG41065D1 BF27_4550 ENOG410635A Membrane BF27_456 ENOG4105S2F BF27_4566 ENOG4108XET gCN5-related N-acetyltransferase BF27_4572 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF27_4574 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF27_4581 ENOG4105FS7 Transcriptional regulator BF27_4582 ENOG4108TVJ Nitroreductase BF27_4584 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF27_4593 ENOG4105C8Y Acetylornithine aminotransferase BF27_4595 ENOG4105CKK Glycosyl transferase, family 2 BF27_4599 ENOG4105CKK Glycosyl transferase, family 2 BF27_46 ENOG4105H67 Protein of unknown function (DUF421) BF27_4604 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF27_4609 ENOG41068WN BF27_4611 ENOG4108WCX response regulator BF27_4613 ENOG41090T1 Membrane BF27_4616 ENOG4105VMP Transcriptional regulator BF27_4618 ENOG4105G6Z alkaline phosphatase BF27_4619 ENOG4105ECK Fatty Acid Desaturase BF27_4620 ENOG4105E0Y RtcB Protein BF27_4622 ENOG4107258 Transcriptional regulator BF27_4624 ENOG4105II7 pyrroline-5-carboxylate reductase BF27_4625 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF27_463 ENOG4107RB3 L-asparaginase BF27_4631 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF27_4635 ENOG41061GT Aldolase BF27_4637 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF27_4638 ENOG4105DKT Transcriptional regulator BF27_464 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF27_4640 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF27_4642 ENOG4105D4B ABC, transporter BF27_4648 ENOG4105EMN RNA polymerase sigma factor BF27_4650 ENOG41069ER domain protein BF27_4657 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF27_4658 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF27_4659 ENOG4105CIH Imidazole acetol-phosphate transaminase BF27_4664 ENOG41082JN Transcriptional regulator BF27_4665 ENOG4105EYF MMPL domain protein BF27_4667 ENOG4105C5H ABC transporter BF27_4668 ENOG4105E0M Sulfatase BF27_4669 ENOG4108ZCF integral membrane protein BF27_4671 ENOG4107VMI polysaccharide deacetylase BF27_4673 ENOG4107VC0 DNA alkylation repair enzyme BF27_4683 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF27_4687 ENOG4105E09 nadh pyrophosphatase BF27_469 ENOG4108S6Z Negative regulator of genetic competence BF27_4692 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF27_4693 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF27_4694 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF27_4696 ENOG4105C02 permease BF27_47 ENOG4105X5K response regulator receiver protein BF27_470 ENOG4107X2D transcriptional regulator, merr family BF27_4704 ENOG4105DVE abc transporter atp-binding protein BF27_471 ENOG4107RGJ metallophosphoesterase BF27_4710 ENOG4105CHM Aminotransferase BF27_4717 ENOG41089UC methyltransferase, type 11 BF27_4720 ENOG4107BMA Transglycosylase associated protein BF27_4724 ENOG4106K7D Major facilitator family transporter BF27_4725 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF27_473 ENOG4105I7S Abortive infection protein BF27_4733 ENOG4105EPR degv family BF27_4735 ENOG4105DPN Oligoendopeptidase f BF27_474 ENOG4105C9U ATP-dependent DNA helicase RecQ BF27_4742 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_4743 ENOG4105BZU Histidine kinase BF27_4744 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF27_4751 ENOG4105DTQ mandelate racemase muconate lactonizing BF27_4754 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF27_4755 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF27_4758 ENOG4107T5V SNARE associated Golgi BF27_4764 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BF27_4766 ENOG41080HI glycine oxidase BF27_4767 ENOG4105CTU Proline racemase BF27_4768 ENOG4105CTU Proline racemase BF27_4769 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF27_477 ENOG4108SAX Membrane BF27_4770 ENOG4105C26 Dehydrogenase BF27_4771 ENOG4105BZG amino acid carrier protein BF27_4774 ENOG4108M1A Chitin-binding protein BF27_4783 ENOG4105C9U ATP-dependent DNA helicase RecQ BF27_4787 ENOG4105EEM helicase BF27_4798 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF27_480 ENOG4108WBT adenosyltransferase BF27_4807 ENOG4108M1A Chitin-binding protein BF27_4808 ENOG41082BV acetyltransferase BF27_4809 ENOG4105E66 phosphoriboisomerase A BF27_481 ENOG4105BZU Histidine kinase BF27_4814 ENOG4108IJ7 Glycine betaine BF27_4815 ENOG4107SQ8 Glycine betaine BF27_482 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_4821 ENOG4105RHY Pfam:UPF0157 BF27_4822 ENOG4105E1F short-chain dehydrogenase reductase BF27_4824 ENOG4107RUY (E1 component), alpha subunit BF27_4826 ENOG4107QKR Dehydrogenase BF27_483 ENOG4105CRE cytochrome C BF27_4831 ENOG41062ES Transcriptional regulator BF27_4836 ENOG4105E98 transcriptional regulator DeoR family BF27_484 ENOG4107TWT Cytochrome c biogenesis protein BF27_4840 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF27_4846 ENOG4107Z3H Transcriptional regulator, TetR family BF27_4847 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF27_4848 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF27_4849 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF27_4853 ENOG4105MSI germination protein ypeb BF27_4857 ENOG4108V3A UPF0421 protein BF27_486 ENOG4105FE9 pseudouridine synthase BF27_4864 ENOG4105FDR Membrane BF27_4866 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF27_4871 ENOG4108IUM Glycogen debranching enzyme BF27_4874 ENOG4105DY8 decarboxylase BF27_4878 ENOG4105PAD Hydrolase BF27_488 ENOG4108JIC nucleoside recognition domain protein BF27_4883 ENOG4107VFR oxidoreductase BF27_489 ENOG4105DZ1 carboxypeptidase BF27_4891 ENOG4105PKS Excinuclease abc c subunit domain protein BF27_4898 ENOG4105KWG Pfam:DUF1696 BF27_4899 ENOG4108NRW Phospholipase, patatin family BF27_49 ENOG4105C8J )-transporter BF27_490 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF27_4905 ENOG4108XI2 Domain of unknown function (DUF1963) BF27_4912 ENOG4108Z4K mutator MutT protein BF27_4913 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF27_4914 ENOG4105E09 nadh pyrophosphatase BF27_4916 ENOG4105FCD Major Facilitator BF27_4923 ENOG4107Y9U Membrane BF27_4928 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF27_4932 ENOG4107Y80 Major Facilitator superfamily BF27_4937 ENOG4108V4B ThiJ pfpI BF27_4946 ENOG4105CJN penicillin-binding protein BF27_4947 ENOG4105CB2 alcohol dehydrogenase BF27_4950 ENOG4108HGU Histidine kinase BF27_4953 ENOG4108JJB ABC transporter BF27_4957 ENOG4107RF6 penicillin-binding protein BF27_4958 ENOG4105BZU Histidine kinase BF27_4960 ENOG410667J hydrolase BF27_497 ENOG4105BZU Histidine kinase BF27_4983 ENOG4105ETU transcriptional activator (TenA BF27_500 ENOG4105I3N Conserved Protein BF27_5003 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF27_5006 ENOG4105CPQ Dehydrogenase BF27_501 ENOG4105BZU Histidine kinase BF27_5012 ENOG4105CUV Homoserine Kinase BF27_5016 ENOG4107Y80 Major Facilitator superfamily BF27_5018 ENOG4105FQP Beta-lactamase BF27_5021 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF27_5021 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF27_5030 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF27_5032 ENOG4105T9C HD domain BF27_5035 ENOG4105DZ1 carboxypeptidase BF27_5038 ENOG4105DBI uridine monophosphokinase BF27_5039 ENOG4105WCN acetyltransferase BF27_504 ENOG4105BZ4 penicillin-binding protein BF27_5041 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF27_5042 ENOG4107QX3 carboxylase BF27_5043 ENOG4105E39 Enoyl-CoA hydratase BF27_5044 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF27_5045 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF27_5046 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF27_5047 ENOG4105C1G acyl-Coa dehydrogenase BF27_505 ENOG4107GRR phosphate transport regulator BF27_5050 ENOG4107Z3H Transcriptional regulator, TetR family BF27_5052 ENOG4105CJ1 ABC, transporter BF27_5055 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF27_5056 ENOG4105CEP NADH dehydrogenase BF27_5057 ENOG4106ANW SMI1_KNR4 BF27_5059 ENOG4105BZU Histidine kinase BF27_506 ENOG4105CJ3 phosphate transporter BF27_5061 ENOG4105C5H ABC transporter BF27_5062 ENOG41067SE Tetr family transcriptional regulator BF27_5067 ENOG4108VXD carboxy-peptidase BF27_5070 ENOG4105VZ8 Transcriptional regulator BF27_5073 ENOG4105CGH 5'-nucleotidase BF27_5076 ENOG4105DH8 myo-inositol catabolism BF27_5077 ENOG4105D2N Aldolase BF27_5082 ENOG4105CK5 oxidoreductase BF27_5083 ENOG4105IE8 Alpha-ketoglutarate permease BF27_5084 ENOG4105ETE Transcriptional regulator (LacI family BF27_5086 ENOG4107RF6 penicillin-binding protein BF27_5087 ENOG4107RF6 penicillin-binding protein BF27_5093 ENOG4105CIN aminoacyl-histidine dipeptidase BF27_510 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF27_5101 ENOG41090HR transcriptional regulator BF27_5102 ENOG4107RA9 decarboxylase BF27_5103 ENOG4108I0C methyltransferase BF27_5105 ENOG41088CC tellurite resistance protein tehB BF27_5109 ENOG4108RZE Tetr family transcriptional regulator BF27_5111 ENOG4105C1J atp-dependent rna helicase BF27_5114 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF27_5118 ENOG4107STF Involved in phosphonate degradation (By similarity) BF27_5120 ENOG4105RD7 BadF BadG BcrA BcrD BF27_5125 ENOG4105F32 YngK protein BF27_5130 ENOG4108KPJ rna polymerase sigma factor BF27_5135 ENOG4108JCI Transcriptional regulator BF27_5139 ENOG4105BZ1 (ABC) transporter BF27_5140 ENOG4105BZ1 (ABC) transporter BF27_5143 ENOG4108RPX mosc domain containing protein BF27_5144 ENOG4105DND Transcriptional regulator BF27_5147 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF27_5148 ENOG4107V2S Transcriptional regulator BF27_515 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF27_5156 ENOG410667J hydrolase BF27_5160 ENOG4105VEQ Cold shock protein BF27_5162 ENOG41068WN BF27_5164 ENOG4105C1Q protoporphyrinogen oxidase BF27_5170 ENOG4105WCN acetyltransferase BF27_5175 ENOG4105EYF MMPL domain protein BF27_5177 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF27_5180 ENOG41081I9 integral membrane protein BF27_5186 ENOG4108D32 Methyltransferase BF27_519 ENOG4105WH1 Two component transcriptional regulator luxr family BF27_5192 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF27_5194 ENOG4105C19 ABC transporter BF27_5195 ENOG4105C22 threonyL-tRNA synthetase BF27_5196 ENOG4105FE9 pseudouridine synthase BF27_520 ENOG4105ENE Histidine kinase BF27_5200 ENOG4105BZG amino acid carrier protein BF27_5204 ENOG4105K70 DNA-binding protein BF27_5207 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_5208 ENOG4105WQT MbtH domain protein BF27_5209 ENOG4105CEY Amp-dependent synthetase and ligase BF27_5210 ENOG4105WQI isochorismatase BF27_5211 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF27_5212 ENOG4105E4F Isochorismate synthase BF27_5213 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF27_5214 ENOG4105FCD Major Facilitator BF27_5218 ENOG4105EYH Exonuclease BF27_5219 ENOG4107RFY SbcCD D subunit BF27_5222 ENOG4105E39 Enoyl-CoA hydratase BF27_5223 ENOG4105N14 lysine exporter protein LysE YggA BF27_5225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF27_5226 ENOG4105C1G acyl-Coa dehydrogenase BF27_5227 ENOG4105CR4 methylisocitrate lyase BF27_5228 ENOG4105DXD 2-methylcitrate dehydratase BF27_5230 ENOG4105W8X HesB YadR YfhF-family protein BF27_5231 ENOG4105CZM Major Facilitator BF27_5232 ENOG4105BZ4 penicillin-binding protein BF27_524 ENOG4105DFD Na H antiporter BF27_5240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF27_5259 ENOG4108IBT Inherit from COG: transposase BF27_5261 ENOG4105SZ6 Thioredoxin BF27_5262 ENOG410841Q phosphoesterase PA-phosphatase related protein BF27_5264 ENOG4108N23 SpoOM-related protein BF27_5272 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF27_5273 ENOG4108JUB Transcriptional regulator BF27_5274 ENOG4108TSC N-acetyltransferase BF27_5275 ENOG4107S4Y M20 DapE family protein YgeY BF27_5278 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF27_528 ENOG4105C8J )-transporter BF27_5283 ENOG4105C37 (CBS) domain BF27_529 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF27_5290 ENOG4105E90 ABC transporter BF27_5291 ENOG4108IJ8 ABC transporter BF27_5297 ENOG4105CMG Carbohydrate kinase BF27_5298 ENOG4105CMG Carbohydrate kinase BF27_53 ENOG4105C6T cysteine synthase BF27_530 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF27_5305 ENOG4106KNT transcriptional regulator BF27_5307 ENOG4105WH1 Two component transcriptional regulator luxr family BF27_5308 ENOG4105BZU Histidine kinase BF27_5309 ENOG4105D8X mechanosensitive ion channel BF27_531 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF27_5310 ENOG4107Y70 Heat shock protein BF27_5316 ENOG4105F0I Aminotransferase BF27_5317 ENOG4108MES Periplasmic binding protein BF27_5321 ENOG4105CAQ asparagine synthetase BF27_5322 ENOG4107Y70 Heat shock protein BF27_5323 ENOG4108KF3 Electron transport protein SCO1 SenC BF27_5324 ENOG4105E8R UPF0173 metal-dependent hydrolase BF27_5325 ENOG4108RCR degv family BF27_5327 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF27_5329 ENOG4108UT2 hemolysin iii BF27_533 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF27_5330 ENOG4105E9Q Acyl-transferase BF27_5331 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF27_5332 ENOG4107RVG penicillin-binding protein BF27_5335 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF27_5339 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF27_534 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF27_5344 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF27_5346 ENOG4105KD7 acetyltransferase BF27_5349 ENOG4105C0A alcohol dehydrogenase BF27_5350 ENOG4105CY2 Citrate transporter BF27_5351 ENOG4107XGZ Hydrolase BF27_5355 ENOG4105C8J )-transporter BF27_5358 ENOG41062D9 Histidine kinase BF27_5359 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_5360 ENOG4107QPK )-transporter BF27_5361 ENOG4105BZW Glycerate kinase BF27_5378 ENOG4105EC2 ftsk spoIIIe BF27_538 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF27_5382 ENOG4105C5S asparaginyl-tRNA synthetase BF27_5383 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF27_5386 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF27_5392 ENOG4105C75 arginyL-tRNA synthetase BF27_5393 ENOG4107YX5 Pfam:DUF548 BF27_5397 ENOG41061H0 Monooxygenase BF27_54 ENOG4105EU0 Major facilitator Superfamily BF27_540 ENOG4105E0M Sulfatase BF27_5400 ENOG4108UUM single-stranded DNA-binding protein BF27_5403 ENOG4105C5H ABC transporter BF27_5407 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF27_541 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF27_5410 ENOG4105MCT stage V sporulation protein S BF27_5417 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF27_5418 ENOG4108IFG nitrite reductase, (NAD(P)H) BF27_5419 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF27_5420 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF27_5421 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF27_5422 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF27_5427 ENOG4108ZAF Molybdopterin BF27_5428 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF27_5429 ENOG4105D06 uba thif-type nad fad binding protein BF27_5430 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF27_5431 ENOG4107V6Q Cyclic nucleotide-binding domain BF27_5433 ENOG4105CZV ABC transporter BF27_5436 ENOG4105R3A Nitrate reductase BF27_5437 ENOG4108IUE nitrate reductase beta subunit BF27_544 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF27_5441 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF27_5444 ENOG4108V06 Glutathione peroxidase BF27_5449 ENOG4105EMN RNA polymerase sigma factor BF27_5450 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF27_5452 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF27_5453 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF27_5457 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF27_5462 ENOG4105KBJ sporulation protein ytfj BF27_5471 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF27_5477 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF27_5478 ENOG4108JYZ YitT family BF27_5479 ENOG41087PP glycosyltransferase MGT family BF27_5482 ENOG4107RBS Methyltransferase BF27_5483 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF27_5485 ENOG4108X4Q Hydrolase BF27_5490 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF27_5492 ENOG4108VXD carboxy-peptidase BF27_5494 ENOG4108ZRV stage ii sporulation protein p BF27_5498 ENOG4108Z7R Chaperone CsaA BF27_5502 ENOG4105C37 (CBS) domain BF27_5503 ENOG4105SXS Protein of unknown function (DUF456) BF27_5507 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF27_5508 ENOG4108S4H thioesterase Superfamily protein BF27_551 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF27_5510 ENOG4108PJD permease BF27_5513 ENOG4107T5V SNARE associated Golgi BF27_5517 ENOG4105CVJ phosphoglycerate mutase BF27_5522 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF27_5524 ENOG4105K4T epimerase BF27_5526 ENOG4105DSE periplasmic solute binding protein BF27_5538 ENOG4105CKI cobalamin synthesis protein BF27_5539 ENOG4107QM2 Aldo Keto reductase BF27_5543 ENOG4105DEN Luciferase family BF27_5546 ENOG4108WPJ Ferritin-like domain BF27_5547 ENOG4108K88 Membrane BF27_5550 ENOG4105C8Q Methyl-accepting chemotaxis BF27_5555 ENOG4107XZQ multidrug resistance protein BF27_5556 ENOG4107SET aldo keto reductase BF27_5557 ENOG4105YVS arsR family transcriptional regulator BF27_5559 ENOG4105KRN Transcriptional regulator, abrb family BF27_556 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF27_5569 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF27_5571 ENOG4105YWU small acid-soluble spore protein BF27_5572 ENOG4108WBH protein TIM barrel BF27_5575 ENOG4105CEY Amp-dependent synthetase and ligase BF27_5576 ENOG4105DUU IucA IucC family protein BF27_5578 ENOG4105VRR gCN5-related N-acetyltransferase BF27_5579 ENOG4105KT7 mgtC SapB transporter BF27_558 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF27_5581 ENOG4107VMI polysaccharide deacetylase BF27_5582 ENOG4105BZU Histidine kinase BF27_5583 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_5585 ENOG4108KGH TRANSCRIPTIONal BF27_559 ENOG4108ZP8 Acetolactate synthase small subunit BF27_5590 ENOG4105D6E homoserine dehydrogenase BF27_5594 ENOG4108ZJ4 polysaccharide deacetylase BF27_5595 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF27_5598 ENOG4105BZU Histidine kinase BF27_5599 ENOG4105EFI regulatoR BF27_56 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF27_560 ENOG4105C7K acetolactate synthase BF27_5600 ENOG4105BZ1 (ABC) transporter BF27_5608 ENOG4108JJ8 (ABC) transporter BF27_5609 ENOG4108JJ9 ABC, transporter BF27_561 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF27_5610 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF27_5611 ENOG4105C4M (Ubiquinol oxidase) subunit I BF27_5613 ENOG4105YGB Transcriptional regulator BF27_5615 ENOG4105MDS 4-oxalocrotonate tautomerase BF27_5617 ENOG4105SKE transcriptional Regulator LysR family BF27_5619 ENOG4105C32 Amino acid ABC transporter (Permease) BF27_5620 ENOG4108IV0 ABC, transporter BF27_5621 ENOG4105C0Z ABC transporter BF27_5623 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF27_5624 ENOG4108Z7G MaoC domain protein dehydratase BF27_5628 ENOG4105CKI cobalamin synthesis protein BF27_5630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF27_5631 ENOG4106F5Q Membrane BF27_5632 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF27_5635 ENOG4108TVJ Nitroreductase BF27_5636 ENOG4107ZXU DSBA oxidoreductase BF27_5637 ENOG4108Z40 Transcriptional regulator BF27_5638 ENOG4105GZI Transcriptional regulator BF27_5639 ENOG4107RT3 EamA-like transporter family BF27_5641 ENOG4105KTB nuclear export factor GLE1 BF27_5642 ENOG4108T5E Copper resistance protein BF27_5651 ENOG4107STQ Multicopper oxidase BF27_5652 ENOG4107RAQ aminopeptidase BF27_5658 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF27_5659 ENOG4105D9N nucleoside BF27_566 ENOG4105KBJ sporulation protein ytfj BF27_5661 ENOG4107RHR regulatoR BF27_567 ENOG41063Y9 BF27_5677 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF27_568 ENOG4105CZN Potassium uptake protein BF27_574 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF27_5746 ENOG4105DHF Membrane BF27_575 ENOG4107QMU Mate efflux family protein BF27_5752 ENOG4106AKK s-layer domain-containing protein BF27_5753 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF27_5755 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF27_5760 ENOG4105DQ6 Transposase BF27_5795 ENOG4105KRN Transcriptional regulator, abrb family BF27_5798 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF27_5805 ENOG4108IBT Inherit from COG: transposase BF27_5807 ENOG4105DQ6 Transposase BF27_5810 ENOG4105DQ6 Transposase BF27_5814 ENOG4108MEK Metal-binding protein YodA BF27_5816 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF27_582 ENOG4105NQC Flavodoxin BF27_5823 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF27_5843 ENOG4105EKQ RNA-directed DNA polymerase BF27_587 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF27_5889 ENOG4107QJE Chromosome Partitioning Protein BF27_589 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF27_5895 ENOG4105DQ6 Transposase BF27_59 ENOG4105DXI Major Facilitator superfamily BF27_590 ENOG4105EA8 2-Nitropropane dioxygenase BF27_5901 ENOG4105EWC Purine nucleoside phosphorylase BF27_591 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF27_5919 ENOG4105C3F Signal peptidase i BF27_5926 ENOG4105N14 lysine exporter protein LysE YggA BF27_5932 ENOG4108J59 Extracellular solute-binding protein, family 5 BF27_5935 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF27_5946 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF27_5947 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF27_5962 ENOG4105K4H Nlp p60 protein BF27_599 ENOG4105CJ1 ABC, transporter BF27_6 ENOG4105C72 UPF0176 protein BF27_60 ENOG4105CSR polyphosphate kinase 2 BF27_601 ENOG4105CZV ABC transporter BF27_602 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF27_603 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF27_604 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF27_606 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF27_607 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF27_615 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF27_616 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF27_618 ENOG4108HGU Histidine kinase BF27_619 ENOG4105BZU Histidine kinase BF27_621 ENOG4106DF1 BF27_623 ENOG41090MY MarR family Transcriptional regulator BF27_624 ENOG4105BZU Histidine kinase BF27_626 ENOG4105PXI polysaccharide deacetylase BF27_633 ENOG4105E98 transcriptional regulator DeoR family BF27_636 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF27_637 ENOG4107RCV ABC transporter, permease BF27_640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF27_642 ENOG4105C4Y ABC transporter BF27_646 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF27_648 ENOG4105CHR reductase BF27_652 ENOG4108Z7G MaoC domain protein dehydratase BF27_653 ENOG410681C small acid-soluble spore protein BF27_654 ENOG4105CZN Potassium uptake protein BF27_655 ENOG4107TS3 membrane protein, TerC BF27_656 ENOG4108QTI )-transporter BF27_658 ENOG4106A3R peptidase BF27_662 ENOG4105JXH GntR family transcriptional regulator BF27_663 ENOG4105BZU Histidine kinase BF27_664 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF27_667 ENOG4105CQB FAD linked oxidase domain protein BF27_668 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF27_669 ENOG4105K4I Scp-like extracellular BF27_671 ENOG4108YBP pseudouridine synthase BF27_673 ENOG4105EYF MMPL domain protein BF27_675 ENOG4107RUE extracellular solute-binding protein family 1 BF27_676 ENOG4105D38 putrescine abc transporter BF27_677 ENOG4105F38 ABC transporter, permease BF27_678 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF27_679 ENOG4105C26 Dehydrogenase BF27_68 ENOG4105FVX BF27_686 ENOG4105VFR signal peptidase BF27_687 ENOG4105DZ1 carboxypeptidase BF27_689 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF27_7 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF27_700 ENOG4105VZ8 Transcriptional regulator BF27_702 ENOG4105C7S Dehydrogenase BF27_720 ENOG4105DDQ anthranilate synthase BF27_721 ENOG4105DDQ anthranilate synthase BF27_722 ENOG4105CRQ synthase (Component I) BF27_723 ENOG4105CK7 Sodium proline symporter BF27_728 ENOG4108WVJ 2'-5' rna ligase BF27_737 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF27_739 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF27_740 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF27_749 ENOG4105K64 Glycosyl transferase, family 2 BF27_753 ENOG4105EMS pseudouridine synthase BF27_754 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF27_757 ENOG4105MIX Adenylate cyclase BF27_758 ENOG4108Z18 K06886 hemoglobin BF27_764 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF27_766 ENOG4108ZCF integral membrane protein BF27_770 ENOG4105UQX Mate efflux family protein BF27_771 ENOG4108JQ7 (ABC) transporter BF27_773 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF27_774 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF27_777 ENOG4105C31 Tryptophanyl-tRNA synthetase BF27_780 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF27_781 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF27_786 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF27_788 ENOG4108KP7 hydrolase BF27_790 ENOG41073B9 BF27_791 ENOG4107AYK membrAne BF27_793 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF27_795 ENOG4105QNR S1 RNA binding domain protein BF27_799 ENOG4105BZU Histidine kinase BF27_80 ENOG4105C6K Malic enzyme BF27_800 ENOG4105CH6 catalase BF27_801 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF27_802 ENOG4105CAQ asparagine synthetase BF27_807 ENOG4105ERH Fumarylacetoacetate hydrolase BF27_81 ENOG4108IJ0 Aspartate ammonia-lyase BF27_816 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF27_817 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF27_820 ENOG4105XVF Competence transcription factor BF27_823 ENOG4105VEQ Cold shock protein BF27_826 ENOG4107QP3 malate synthase g BF27_827 ENOG4105ZU5 s-layer protein BF27_83 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF27_831 ENOG4105C8Q Methyl-accepting chemotaxis BF27_832 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF27_837 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF27_840 ENOG41086D8 Transcriptional regulator BF27_841 ENOG4108AEY RNA polymerase sigma factor BF27_843 ENOG4107TVP HD domain protein BF27_844 ENOG4107RN3 metallophosphoesterase BF27_845 ENOG4105ENX hydrolase BF27_850 ENOG4105CNA YD repeat protein BF27_856 ENOG4105CEY Amp-dependent synthetase and ligase BF27_858 ENOG4105DF9 Lipoate-protein, ligase BF27_859 ENOG4108RQ5 Beta-lactamase domain-containing protein BF27_860 ENOG4106AXD BF27_866 ENOG4105ECB domain protein BF27_869 ENOG4105NA0 Transcriptional regulator BF27_87 ENOG4105CJ1 ABC, transporter BF27_874 ENOG4105C1Q protoporphyrinogen oxidase BF27_876 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF27_877 ENOG4105BZ4 penicillin-binding protein BF27_878 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF27_881 ENOG410905X membrane-flanked domain protein BF27_889 ENOG4105CKV Membrane BF27_890 ENOG410905X membrane-flanked domain protein BF27_897 ENOG4105K59 histidine triad (HIT) protein BF27_902 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF27_903 ENOG4105EEM helicase BF27_905 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_906 ENOG4105C57 major facilitator superfamily BF27_911 ENOG4105EMN RNA polymerase sigma factor BF27_914 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF27_917 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF27_918 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF27_922 ENOG4108MUZ hydrolase BF27_927 ENOG4105EQ0 Major Facilitator superfamily BF27_928 ENOG4108IND Tetr family transcriptional regulator BF27_93 ENOG4106BRA Membrane BF27_931 ENOG4105D7V transposase BF27_932 ENOG4106D4I domain protein BF27_933 ENOG4107VRP DNA repair exonuclease BF27_939 ENOG4105K8R UPF0145 protein BF27_944 ENOG4105BZU Histidine kinase BF27_945 ENOG4105BZU Histidine kinase BF27_946 ENOG4108MJI response regulator BF27_948 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF27_950 ENOG4105WN5 stage II sporulation protein BF27_963 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF27_968 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF27_969 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF27_970 ENOG4105CMT Dihydroxyacetone kinase BF27_972 ENOG4105CMT Dihydroxyacetone kinase BF27_976 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF27_980 ENOG4108IG5 Transcriptional regulator BF27_981 ENOG4107P5I polyketide synthase BF27_991 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF27_999 ENOG4105CDU Replicative dna helicase