locus-tag	class	description
KM412_00010	COG0592	DNA-directed DNA polymerase activity
KM412_00015	COG2501	S4 domain
KM412_00025	COG0187	DNA topoisomerase II activity
KM412_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM412_00065	COG0516	GMP reductase activity
KM412_00065	COG0517	IMP dehydrogenase activity
KM412_00070	COG1686	Belongs to the peptidase S11 family
KM412_00100	COG1428	Deoxynucleoside kinase
KM412_00105	COG1428	Deoxynucleoside kinase
KM412_00110	COG1335	isochorismatase
KM412_00115	COG0590	tRNA wobble adenosine to inosine editing
KM412_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM412_00180	COG1982	Orn Lys Arg decarboxylase major
KM412_00190	COG0470	DNA polymerase III
KM412_00195	COG1774	PSP1 C-terminal conserved region
KM412_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM412_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM412_00220	COG2002	toxin-antitoxin pair type II binding
KM412_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM412_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM412_00230	COG0084	hydrolase, TatD family'
KM412_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM412_00250	COG4466	Protein conserved in bacteria
KM412_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM412_00270	COG0251	oxidation-reduction process
KM412_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM412_00305	COG2002	toxin-antitoxin pair type II binding
KM412_00310	COG2244	polysaccharide biosynthetic process
KM412_00315	COG3956	TIGRFAM MazG family protein
KM412_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM412_00340	COG1098	S1 RNA binding domain
KM412_00355	COG2208	phosphoserine phosphatase activity
KM412_00360	COG0037	tRNA processing
KM412_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM412_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM412_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM412_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM412_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM412_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM412_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM412_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM412_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM412_00420	COG1396	sequence-specific DNA binding
KM412_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM412_00455	COG3880	PFAM UvrB UvrC protein
KM412_00465	COG0542	response to heat
KM412_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM412_00480	COG4956	integral membrane protein (PIN domain superfamily)
KM412_00500	COG1045	serine acetyltransferase
KM412_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM412_00520	COG3688	RNA-binding protein containing a PIN domain
KM412_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM412_00540	COG0250	Participates in transcription elongation, termination and antitermination
KM412_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM412_00565	COG2813	Specifically methylates the guanine in position
KM412_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM412_00580	COG1358	cellular component organization or biogenesis
KM412_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM412_00710	COG0201	protein transport
KM412_00720	COG0024	Methionine aminopeptidase
KM412_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM412_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM412_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM412_00795	COG0489	protein tyrosine kinase activity
KM412_00805	COG2194	sulfuric ester hydrolase activity
KM412_00810	COG0726	polysaccharide deacetylase
KM412_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM412_00895	COG4856	YbbR-like protein
KM412_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM412_00915	COG0596	Alpha beta hydrolase
KM412_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM412_00940	COG1506	peptidase
KM412_00940	COG4946	Tricorn protease homolog
KM412_00940	COG0823	Involved in the tonB-independent uptake of proteins
KM412_00975	COG2011	ABC-type metal ion transport system permease component
KM412_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM412_00985	COG1464	Belongs to the NlpA lipoprotein family
KM412_00990	COG0604	alcohol dehydrogenase
KM412_01000	COG0277	FAD linked oxidase domain protein
KM412_01005	COG2271	Major facilitator Superfamily
KM412_01015	COG2814	Major facilitator Superfamily
KM412_01030	COG0601	transmembrane transport
KM412_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM412_01040	COG0444	Belongs to the ABC transporter superfamily
KM412_01045	COG4608	Belongs to the ABC transporter superfamily
KM412_01050	COG4166	transmembrane transport
KM412_01060	COG2207	Transcriptional regulator
KM412_01075	COG4166	transmembrane transport
KM412_01080	COG4166	transmembrane transport
KM412_01085	COG0656	L-ascorbic acid biosynthetic process
KM412_01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM412_01105	COG4149	molybdate abc transporter
KM412_01115	COG1910	domain protein
KM412_01125	COG0583	DNA-binding transcription factor activity
KM412_01130	COG0697	spore germination
KM412_01145	COG0204	Acyl-transferase
KM412_01155	COG1609	Transcriptional regulator
KM412_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_01175	COG0084	hydrolase, TatD family'
KM412_01180	COG5298	Protein conserved in bacteria
KM412_01205	COG0488	(ABC) transporter
KM412_01220	COG0747	negative chemotaxis
KM412_01225	COG0601	transmembrane transport
KM412_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM412_01235	COG0444	Belongs to the ABC transporter superfamily
KM412_01240	COG4608	Belongs to the ABC transporter superfamily
KM412_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM412_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM412_01290	COG2814	Major facilitator Superfamily
KM412_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM412_01310	COG4294	response to UV
KM412_01315	COG0457	Tetratricopeptide repeat
KM412_01315	COG0705	Rhomboid family
KM412_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM412_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM412_01335	COG0864	Transcriptional regulator
KM412_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM412_01345	COG2183	response to ionizing radiation
KM412_01440	COG0802	atpase or kinase
KM412_01445	COG1214	PFAM Peptidase M22, glycoprotease
KM412_01450	COG0456	acetyltransferase
KM412_01460	COG0488	(ABC) transporter
KM412_01475	COG1266	CAAX protease self-immunity
KM412_01495	COG2252	PERMEase
KM412_01505	COG5002	protein histidine kinase activity
KM412_01535	COG2226	methyltransferase
KM412_01575	COG1968	undecaprenyl-diphosphatase activity
KM412_01590	COG2205	protein histidine kinase activity
KM412_01595	COG0745	RESPONSE REGULATOR receiver
KM412_01615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM412_01620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM412_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM412_01635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM412_01650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM412_01660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM412_01670	COG0151	Belongs to the GarS family
KM412_01695	COG0210	DNA helicase
KM412_01705	COG4851	CamS sex pheromone cAM373 precursor
KM412_01725	COG1335	isochorismatase
KM412_01730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM412_01735	COG2011	ABC-type metal ion transport system permease component
KM412_01740	COG1464	Belongs to the NlpA lipoprotein family
KM412_01760	COG1846	Transcriptional regulator
KM412_01785	COG1597	lipid kinase activity
KM412_01790	COG0546	phosphoglycolate phosphatase activity
KM412_01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM412_01805	COG1012	belongs to the aldehyde dehydrogenase family
KM412_01810	COG2076	Multidrug Resistance protein
KM412_01815	COG2309	aminopeptidase activity
KM412_01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM412_01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM412_01850	COG4807	Protein conserved in bacteria
KM412_01875	COG1757	Na H antiporter
KM412_01880	COG1473	amidohydrolase
KM412_01895	COG0450	alkyl hydroperoxide reductase
KM412_01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_01940	COG0166	Belongs to the GPI family
KM412_01975	COG5002	protein histidine kinase activity
KM412_01995	COG3541	Predicted nucleotidyltransferase
KM412_02000	COG2814	Major facilitator Superfamily
KM412_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM412_02005	COG0723	plastoquinol--plastocyanin reductase activity
KM412_02015	COG0765	amino acid transport
KM412_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM412_02030	COG0840	transmembrane signaling receptor activity
KM412_02035	COG0840	transmembrane signaling receptor activity
KM412_02040	COG0366	Alpha amylase catalytic
KM412_02045	COG1263	PTS System
KM412_02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_02045	COG2190	(PTS) system
KM412_02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM412_02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM412_02100	COG1116	anion transmembrane transporter activity
KM412_02105	COG0488	(ABC) transporter
KM412_02150	COG2270	Major facilitator Superfamily
KM412_02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM412_02180	COG2310	stress, protein
KM412_02185	COG2310	stress, protein
KM412_02190	COG2310	stress, protein
KM412_02195	COG0861	Integral membrane protein TerC family
KM412_02205	COG3853	Toxic anion resistance protein (TelA)
KM412_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM412_02230	COG1295	ribonuclease BN
KM412_02235	COG2217	Heavy metal translocating P-type atpase
KM412_02240	COG0697	spore germination
KM412_02260	COG0586	Pfam SNARE associated Golgi protein
KM412_02275	COG3871	stress protein (general stress protein 26)
KM412_02280	COG0387	Pfam Sodium calcium exchanger
KM412_02290	COG0535	radical SAM domain protein
KM412_02315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM412_02320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM412_02325	COG0582	viral genome integration into host DNA
KM412_02335	COG1396	sequence-specific DNA binding
KM412_02350	COG1396	sequence-specific DNA binding
KM412_02385	COG1484	DNA-dependent DNA replication
KM412_02615	COG0101	tRNA pseudouridine synthase activity
KM412_02625	COG3829	transcription factor binding
KM412_02635	COG0833	amino acid
KM412_02640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM412_02670	COG1263	PTS System
KM412_02670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_02675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM412_02690	COG0463	Glycosyl transferase, family 2
KM412_02705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM412_02705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM412_02725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM412_02745	COG1228	amidohydrolase
KM412_02750	COG1090	epimerase
KM412_02780	COG1988	membrane-bound metal-dependent
KM412_02785	COG1194	a g-specific adenine glycosylase
KM412_02810	COG1132	(ABC) transporter
KM412_02815	COG4129	membrane
KM412_02820	COG0069	glutamate synthase activity
KM412_02820	COG0067	glutamate synthase
KM412_02820	COG0070	glutamate synthase
KM412_02830	COG4555	ABC transporter
KM412_02850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM412_02855	COG0735	belongs to the Fur family
KM412_02970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM412_02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM412_02985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM412_02995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM412_03005	COG2766	serine protein kinase
KM412_03025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM412_03035	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM412_03040	COG2268	Band 7 protein
KM412_03050	COG3290	protein histidine kinase activity
KM412_03055	COG4565	transcriptional regulatory protein
KM412_03060	COG2851	Citrate transporter
KM412_03080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM412_03085	COG3842	ATPase activity
KM412_03090	COG1175	transmembrane transport
KM412_03095	COG0395	ABC-type sugar transport system, permease component
KM412_03105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM412_03110	COG0745	RESPONSE REGULATOR receiver
KM412_03115	COG5002	protein histidine kinase activity
KM412_03125	COG4990	cell redox homeostasis
KM412_03135	COG3290	protein histidine kinase activity
KM412_03140	COG4565	transcriptional regulatory protein
KM412_03145	COG3493	citrate carrier protein
KM412_03150	COG0281	malic enzyme
KM412_03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_03175	COG5002	protein histidine kinase activity
KM412_03180	COG0745	RESPONSE REGULATOR receiver
KM412_03185	COG0454	-acetyltransferase
KM412_03185	COG0456	acetyltransferase
KM412_03190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM412_03195	COG3383	formate dehydrogenase (NAD+) activity
KM412_03200	COG2427	Protein of unknown function (DUF1641)
KM412_03215	COG0531	amino acid
KM412_03220	COG0640	Transcriptional regulator
KM412_03225	COG2217	Heavy metal translocating P-type atpase
KM412_03230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM412_03245	COG3227	Zinc metalloprotease (Elastase)
KM412_03265	COG2720	vancomycin resistance protein
KM412_03270	COG1316	TRANSCRIPTIONal
KM412_03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_03280	COG0346	lactoylglutathione lyase activity
KM412_03285	COG1253	flavin adenine dinucleotide binding
KM412_03290	COG1027	Aspartate ammonia-lyase
KM412_03295	COG1620	l-lactate permease
KM412_03310	COG3104	oligopeptide transport
KM412_03315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_03335	COG2226	methyltransferase
KM412_03340	COG0156	8-amino-7-oxononanoate synthase activity
KM412_03345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM412_03355	COG4548	von Willebrand factor, type A
KM412_03360	COG0714	Associated with various cellular activities
KM412_03365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM412_03385	COG0531	amino acid
KM412_03390	COG2188	Transcriptional regulator
KM412_03395	COG1263	PTS System
KM412_03395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_03400	COG0366	Alpha amylase catalytic
KM412_03415	COG0697	spore germination
KM412_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM412_03430	COG1115	amino acid carrier protein
KM412_03435	COG1126	abc transporter atp-binding protein
KM412_03440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM412_03445	COG0765	amino acid transport
KM412_03450	COG0765	amino acid transport
KM412_03455	COG0833	amino acid
KM412_03480	COG2378	regulation of single-species biofilm formation
KM412_03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM412_03490	COG5002	protein histidine kinase activity
KM412_03505	COG0659	secondary active sulfate transmembrane transporter activity
KM412_03520	COG0747	negative chemotaxis
KM412_03530	COG0601	transmembrane transport
KM412_03535	COG4608	Belongs to the ABC transporter superfamily
KM412_03545	COG2271	Major facilitator Superfamily
KM412_03550	COG1846	Transcriptional regulator
KM412_03560	COG1609	Transcriptional regulator
KM412_03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM412_03580	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM412_03585	COG1879	ABC-type sugar transport system periplasmic component
KM412_03610	COG1063	alcohol dehydrogenase
KM412_03625	COG3568	Endonuclease Exonuclease Phosphatase
KM412_03650	COG1968	undecaprenyl-diphosphatase activity
KM412_03655	COG0840	transmembrane signaling receptor activity
KM412_03660	COG3584	3D domain protein
KM412_03660	COG1388	LysM domain
KM412_03665	COG1476	TRANSCRIPTIONal
KM412_03680	COG3104	oligopeptide transport
KM412_03685	COG1114	Component of the transport system for branched-chain amino acids
KM412_03700	COG1113	amino acid transport
KM412_03705	COG2252	PERMEase
KM412_03730	COG0475	glutathione-regulated potassium exporter activity
KM412_03730	COG0569	domain protein
KM412_03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM412_03750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM412_03755	COG0833	amino acid
KM412_03760	COG4990	cell redox homeostasis
KM412_03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM412_03780	COG0697	spore germination
KM412_03785	COG0531	amino acid
KM412_03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM412_03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM412_03805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM412_03805	COG1918	ferrous iron import across plasma membrane
KM412_03810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM412_03815	COG0573	inorganic phosphate transmembrane transporter activity
KM412_03820	COG0581	inorganic phosphate transmembrane transporter activity
KM412_03830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM412_03950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM412_03970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM412_03975	COG1116	anion transmembrane transporter activity
KM412_03980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM412_03985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM412_03990	COG0352	thiamine-phosphate diphosphorylase activity
KM412_03995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM412_04000	COG2104	thiamine diphosphate biosynthetic process
KM412_04010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM412_04015	COG0351	phosphomethylpyrimidine kinase
KM412_04055	COG2205	protein histidine kinase activity
KM412_04060	COG2814	Major facilitator Superfamily
KM412_04065	COG1846	Transcriptional regulator
KM412_04080	COG2252	PERMEase
KM412_04085	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM412_04105	COG1621	beta-fructofuranosidase activity
KM412_04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_04110	COG1263	PTS System
KM412_04115	COG1609	Transcriptional regulator
KM412_04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM412_04130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM412_04165	COG0778	Nitroreductase
KM412_04170	COG2719	SpoVR family
KM412_04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM412_04200	COG1937	Protein conserved in bacteria
KM412_04205	COG0425	Belongs to the sulfur carrier protein TusA family
KM412_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_04215	COG0425	Belongs to the sulfur carrier protein TusA family
KM412_04220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_04230	COG2210	Belongs to the sulfur carrier protein TusA family
KM412_04235	COG0730	response to heat
KM412_04245	COG1316	TRANSCRIPTIONal
KM412_04250	COG0604	alcohol dehydrogenase
KM412_04255	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM412_04270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM412_04270	COG3711	transcriptional antiterminator
KM412_04275	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM412_04280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM412_04300	COG1388	LysM domain
KM412_04300	COG3584	3D domain protein
KM412_04305	COG0577	efflux transmembrane transporter activity
KM412_04310	COG1136	(ABC) transporter
KM412_04320	COG5522	Integral membrane protein (intg_mem_TP0381)
KM412_04335	COG1114	Component of the transport system for branched-chain amino acids
KM412_04340	COG3546	catalase activity
KM412_04375	COG0586	Pfam SNARE associated Golgi protein
KM412_04410	COG0531	amino acid
KM412_04415	COG0475	glutathione-regulated potassium exporter activity
KM412_04425	COG1737	Transcriptional regulator
KM412_04435	COG1263	PTS System
KM412_04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_04445	COG2259	Doxx family
KM412_04460	COG0697	spore germination
KM412_04465	COG1522	sequence-specific DNA binding
KM412_04480	COG2076	Multidrug Resistance protein
KM412_04485	COG1309	transcriptional regulator
KM412_04490	COG2814	Major facilitator Superfamily
KM412_04495	COG1733	regulation of RNA biosynthetic process
KM412_04505	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM412_04510	COG4533	DNA binding
KM412_04515	COG2211	Major facilitator Superfamily
KM412_04525	COG0693	protein deglycase activity
KM412_04530	COG0693	protein deglycase activity
KM412_04530	COG0753	catalase activity
KM412_04540	COG0531	amino acid
KM412_04545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM412_04555	COG1012	belongs to the aldehyde dehydrogenase family
KM412_04560	COG1132	(ABC) transporter
KM412_04570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM412_04575	COG0765	amino acid transport
KM412_04580	COG1126	abc transporter atp-binding protein
KM412_04595	COG0189	ligase activity
KM412_04625	COG0028	Belongs to the TPP enzyme family
KM412_04630	COG3527	Alpha-acetolactate decarboxylase
KM412_04645	COG0561	phosphatase activity
KM412_04660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM412_04675	COG0659	secondary active sulfate transmembrane transporter activity
KM412_04695	COG0653	protein targeting
KM412_04700	COG2244	polysaccharide biosynthetic process
KM412_04710	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM412_04715	COG4196	transglutaminase domain protein
KM412_04730	COG1696	Membrane protein involved in D-alanine export
KM412_04745	COG1024	Enoyl-CoA hydratase
KM412_04765	COG1363	Peptidase, m42
KM412_04785	COG3938	Belongs to the proline racemase family
KM412_04825	COG0601	transmembrane transport
KM412_04830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM412_04840	COG4608	Belongs to the ABC transporter superfamily
KM412_04845	COG0322	excinuclease ABC activity
KM412_04875	COG0477	Major facilitator Superfamily
KM412_04880	COG3290	protein histidine kinase activity
KM412_04885	COG4565	transcriptional regulatory protein
KM412_04890	COG3181	Tripartite tricarboxylate transporter family receptor
KM412_04920	COG0789	Transcriptional regulator
KM412_04920	COG4978	Transcriptional regulator
KM412_04935	COG0305	Participates in initiation and elongation during chromosome replication
KM412_04975	COG0477	Major facilitator Superfamily
KM412_05020	COG3320	Male sterility
KM412_05020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM412_05025	COG1309	transcriptional regulator
KM412_05045	COG1183	phosphatidylcholine synthase activity
KM412_05065	COG2376	Dihydroxyacetone kinase
KM412_05075	COG2376	Dihydroxyacetone kinase
KM412_05080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM412_05085	COG1959	2 iron, 2 sulfur cluster binding
KM412_05115	COG3437	response regulator, receiver
KM412_05115	COG2770	Histidine kinase
KM412_05165	COG3237	CsbD-like
KM412_05190	COG1191	sigma factor activity
KM412_05200	COG2208	phosphoserine phosphatase activity
KM412_05205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM412_05210	COG2205	protein histidine kinase activity
KM412_05210	COG0784	Response regulator, receiver
KM412_05210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM412_05210	COG2198	Histidine kinase
KM412_05265	COG0420	3'-5' exonuclease activity
KM412_05270	COG4717	serine-type aminopeptidase activity
KM412_05290	COG1309	transcriptional regulator
KM412_05295	COG2814	Major facilitator Superfamily
KM412_05300	COG0346	lactoylglutathione lyase activity
KM412_05310	COG0346	lactoylglutathione lyase activity
KM412_05315	COG0457	Tetratricopeptide repeat
KM412_05320	COG2267	carboxylic ester hydrolase activity
KM412_05340	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM412_05345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM412_05355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM412_05395	COG0477	Major facilitator Superfamily
KM412_05400	COG0477	Major facilitator Superfamily
KM412_05410	COG3973	AAA domain
KM412_05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM412_05435	COG4980	gas vesicle protein
KM412_05440	COG0537	adenosine 5'-monophosphoramidase activity
KM412_05445	COG1131	(ABC) transporter
KM412_05450	COG4473	ABC transporter
KM412_05465	COG1309	transcriptional regulator
KM412_05475	COG3402	PFAM membrane-flanked domain
KM412_05525	COG3402	PFAM membrane-flanked domain
KM412_05530	COG3428	Bacterial PH domain
KM412_05535	COG2329	Antibiotic biosynthesis monooxygenase
KM412_05540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM412_05545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM412_05550	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM412_05555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM412_05590	COG1309	transcriptional regulator
KM412_05595	COG1511	domain protein
KM412_05620	COG1609	Transcriptional regulator
KM412_05630	COG1234	tRNA 3'-trailer cleavage
KM412_05635	COG0095	Lipoate-protein ligase
KM412_05645	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_05675	COG3209	COG3209 Rhs family protein
KM412_05715	COG1078	dGTPase activity
KM412_05725	COG1595	DNA-templated transcription, initiation
KM412_05730	COG2207	Transcriptional regulator
KM412_05730	COG3708	Transcriptional regulator
KM412_05745	COG2205	protein histidine kinase activity
KM412_05750	COG0745	RESPONSE REGULATOR receiver
KM412_05775	COG0501	Belongs to the peptidase M48B family
KM412_05780	COG0840	transmembrane signaling receptor activity
KM412_05785	COG0697	spore germination
KM412_05805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM412_05810	COG2224	Isocitrate lyase
KM412_05835	COG4903	ComK protein
KM412_05840	COG0398	Pfam SNARE associated Golgi protein
KM412_05850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM412_05855	COG1074	ATP-dependent DNA helicase activity
KM412_05900	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM412_05925	COG0367	asparagine synthase
KM412_05930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM412_05935	COG0753	catalase activity
KM412_05940	COG0004	ammonium transporteR
KM412_05960	COG2996	Protein conserved in bacteria
KM412_05970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM412_05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_05995	COG0561	phosphatase activity
KM412_06005	COG0542	response to heat
KM412_06015	COG2267	carboxylic ester hydrolase activity
KM412_06030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_06035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM412_06040	COG5504	Zn-dependent protease
KM412_06050	COG0180	Tryptophanyl-tRNA synthetase
KM412_06060	COG4166	transmembrane transport
KM412_06065	COG0601	transmembrane transport
KM412_06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM412_06075	COG0444	Belongs to the ABC transporter superfamily
KM412_06080	COG4608	Belongs to the ABC transporter superfamily
KM412_06085	COG0534	Mate efflux family protein
KM412_06090	COG4166	transmembrane transport
KM412_06105	COG0861	Integral membrane protein TerC family
KM412_06110	COG4862	establishment of competence for transformation
KM412_06115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM412_06125	COG1164	Oligoendopeptidase f
KM412_06135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM412_06140	COG2346	COG2346, Truncated hemoglobins
KM412_06145	COG4116	CYTH
KM412_06155	COG2357	RelA SpoT domain protein
KM412_06165	COG0564	pseudouridine synthase activity
KM412_06185	COG0463	Glycosyl transferase, family 2
KM412_06185	COG1216	Glycosyl transferase, family 2
KM412_06205	COG0457	Tetratricopeptide repeat
KM412_06205	COG0463	Glycosyl transferase, family 2
KM412_06225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM412_06240	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM412_06285	COG2153	protein acetylation
KM412_06295	COG2382	esterase
KM412_06310	COG5492	domain, Protein
KM412_06315	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM412_06325	COG0512	Glutamine amidotransferase of anthranilate synthase
KM412_06325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM412_06360	COG1620	l-lactate permease
KM412_06365	COG5634	Uncharacterized conserved protein (DUF2278)
KM412_06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM412_06430	COG1476	TRANSCRIPTIONal
KM412_06490	COG2226	methyltransferase
KM412_06500	COG1686	Belongs to the peptidase S11 family
KM412_06505	COG0681	Belongs to the peptidase S26 family
KM412_06540	COG1012	belongs to the aldehyde dehydrogenase family
KM412_06545	COG3842	ATPase activity
KM412_06550	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM412_06555	COG1177	transmembrane transport
KM412_06560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM412_06570	COG2409	Drug exporters of the RND superfamily
KM412_06580	COG0564	pseudouridine synthase activity
KM412_06590	COG2340	Cysteine-rich secretory protein family
KM412_06595	COG0247	lactate metabolic process
KM412_06600	COG0277	FAD linked oxidase domain protein
KM412_06605	COG3835	regulator
KM412_06615	COG0745	RESPONSE REGULATOR receiver
KM412_06620	COG5002	protein histidine kinase activity
KM412_06625	COG2186	Transcriptional regulator
KM412_06645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM412_06660	COG2116	formate transmembrane transporter activity
KM412_06665	COG0861	Integral membrane protein TerC family
KM412_06670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM412_06680	COG2030	dehydratase
KM412_06700	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_06705	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM412_06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM412_06715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM412_06730	COG1840	ABC-type Fe3 transport system, periplasmic component
KM412_06760	COG1349	DNA-binding transcription factor activity
KM412_06780	COG2861	carbohydrate metabolic process
KM412_06790	COG3852	Histidine kinase
KM412_06795	COG1846	Transcriptional regulator
KM412_06805	COG2318	DinB family
KM412_06810	COG5002	protein histidine kinase activity
KM412_06820	COG0720	synthase
KM412_06835	COG4873	Protein conserved in bacteria
KM412_06865	COG1780	Probably involved in ribonucleotide reductase function
KM412_06885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM412_06890	COG1725	Transcriptional regulator
KM412_06895	COG1131	(ABC) transporter
KM412_06905	COG1131	(ABC) transporter
KM412_06910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM412_06925	COG1522	sequence-specific DNA binding
KM412_06935	COG1335	isochorismatase
KM412_06945	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM412_06950	COG2070	2-Nitropropane dioxygenase
KM412_06955	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM412_06965	COG1696	Membrane protein involved in D-alanine export
KM412_06990	COG0716	FMN binding
KM412_07005	COG3173	Aminoglycoside phosphotransferase
KM412_07025	COG0534	Mate efflux family protein
KM412_07030	COG1968	undecaprenyl-diphosphatase activity
KM412_07045	COG1846	Transcriptional regulator
KM412_07055	COG1301	dicarboxylic acid transport
KM412_07060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM412_07065	COG4709	membrane
KM412_07070	COG3874	Sporulation protein YtfJ
KM412_07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM412_07100	COG0028	Belongs to the TPP enzyme family
KM412_07105	COG0440	acetolactate synthase activity
KM412_07110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM412_07120	COG0473	3-isopropylmalate dehydrogenase activity
KM412_07145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM412_07180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM412_07195	COG1183	phosphatidylcholine synthase activity
KM412_07200	COG1368	sulfuric ester hydrolase activity
KM412_07210	COG0019	diaminopimelate decarboxylase activity
KM412_07230	COG0529	Catalyzes the synthesis of activated sulfate
KM412_07235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM412_07255	COG1648	precorrin-2 dehydrogenase activity
KM412_07260	COG0733	neurotransmitter:sodium symporter activity
KM412_07280	COG1757	Na H antiporter
KM412_07295	COG4758	membrane
KM412_07300	COG4585	Histidine kinase
KM412_07305	COG2197	response regulator
KM412_07315	COG1114	Component of the transport system for branched-chain amino acids
KM412_07325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM412_07350	COG1017	nitric oxide dioxygenase activity
KM412_07350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM412_07365	COG0730	response to heat
KM412_07370	COG0306	phosphate transporter
KM412_07375	COG1392	Phosphate transport regulator
KM412_07380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM412_07400	COG1801	Protein of unknown function DUF72
KM412_07410	COG0582	viral genome integration into host DNA
KM412_07415	COG5002	protein histidine kinase activity
KM412_07435	COG0392	lysyltransferase activity
KM412_07435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM412_07450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM412_07455	COG1686	Belongs to the peptidase S11 family
KM412_07460	COG2715	membrane protein required for spore maturation
KM412_07465	COG0700	Nucleoside recognition
KM412_07470	COG1187	pseudouridine synthase activity
KM412_07480	COG1333	cytochrome c biogenesis protein
KM412_07485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM412_07490	COG0745	RESPONSE REGULATOR receiver
KM412_07495	COG5002	protein histidine kinase activity
KM412_07500	COG2096	Adenosyltransferase
KM412_07515	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM412_07520	COG1141	Ferredoxin
KM412_07525	COG4955	Helix-turn-helix domain
KM412_07530	COG0514	ATP-dependent DNA helicase (RecQ)
KM412_07535	COG1266	CAAX protease self-immunity
KM412_07555	COG4862	establishment of competence for transformation
KM412_07560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM412_07580	COG0492	ferredoxin-NADP+ reductase activity
KM412_07655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM412_07670	COG0142	geranyltranstransferase activity
KM412_07680	COG0142	geranyltranstransferase activity
KM412_07700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM412_07705	COG0457	Tetratricopeptide repeat
KM412_07725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM412_07735	COG4347	Protein of unknown function (DUF1405)
KM412_07750	COG2738	Putative neutral zinc metallopeptidase
KM412_07760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_07765	COG1694	Mazg nucleotide pyrophosphohydrolase
KM412_07780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM412_07785	COG0438	transferase activity, transferring glycosyl groups
KM412_07820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM412_07820	COG1199	ATP-dependent helicase activity
KM412_07840	COG3935	DnaD domain protein
KM412_07845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM412_07855	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM412_07855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM412_07915	COG0116	Belongs to the methyltransferase superfamily
KM412_07925	COG1199	ATP-dependent helicase activity
KM412_07930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM412_07940	COG3173	Aminoglycoside phosphotransferase
KM412_07945	COG0024	Methionine aminopeptidase
KM412_07955	COG2233	PERMEase
KM412_07960	COG2311	Membrane
KM412_07965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM412_07975	COG0456	acetyltransferase
KM412_08025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM412_08050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM412_08065	COG1215	transferase activity, transferring glycosyl groups
KM412_08070	COG0438	transferase activity, transferring glycosyl groups
KM412_08085	COG0454	-acetyltransferase
KM412_08105	COG0328	RNA-DNA hybrid ribonuclease activity
KM412_08145	COG1280	lysine exporter protein (LysE YggA)
KM412_08160	COG3162	membrane
KM412_08165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM412_08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM412_08180	COG0475	glutathione-regulated potassium exporter activity
KM412_08185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM412_08190	COG0789	Transcriptional regulator
KM412_08190	COG4978	Transcriptional regulator
KM412_08200	COG2323	membrane
KM412_08205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM412_08260	COG1923	regulation of RNA biosynthetic process
KM412_08270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM412_08275	COG1360	Flagellar Motor Protein
KM412_08280	COG2201	protein-glutamate methylesterase activity
KM412_08285	COG0643	Histidine kinase
KM412_08285	COG2198	Histidine kinase
KM412_08290	COG0643	Histidine kinase
KM412_08290	COG2198	Histidine kinase
KM412_08295	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM412_08295	COG1776	CheC inhibitor of MCP methylation
KM412_08310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM412_08330	COG1256	bacterial-type flagellum assembly
KM412_08355	COG1815	bacterial-type flagellum-dependent cell motility
KM412_08360	COG1558	bacterial-type flagellum-dependent cell motility
KM412_08375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM412_08385	COG1157	protein secretion by the type III secretion system
KM412_08425	COG0784	Response regulator, receiver
KM412_08425	COG0835	chemotaxis
KM412_08435	COG0463	Glycosyl transferase, family 2
KM412_08470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM412_08475	COG0741	lytic transglycosylase activity
KM412_08490	COG1776	CheC inhibitor of MCP methylation
KM412_08490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM412_08500	COG1338	Plays a role in the flagellum-specific transport system
KM412_08505	COG1987	bacterial-type flagellum assembly
KM412_08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM412_08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM412_08525	COG1419	protein localization to endoplasmic reticulum
KM412_08530	COG4786	Flagellar basal body rod
KM412_08535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM412_08560	COG1309	transcriptional regulator
KM412_08580	COG2329	Antibiotic biosynthesis monooxygenase
KM412_08605	COG0583	DNA-binding transcription factor activity
KM412_08610	COG3842	ATPase activity
KM412_08615	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM412_08625	COG1234	tRNA 3'-trailer cleavage
KM412_08650	COG1686	Belongs to the peptidase S11 family
KM412_08660	COG0406	alpha-ribazole phosphatase activity
KM412_08690	COG0367	asparagine synthase
KM412_08720	COG1802	Transcriptional regulator
KM412_08725	COG0697	spore germination
KM412_08730	COG0523	cobalamin synthesis protein
KM412_08735	COG0701	Predicted permease
KM412_08745	COG0438	transferase activity, transferring glycosyl groups
KM412_08745	COG1216	Glycosyl transferase, family 2
KM412_08750	COG1757	Na H antiporter
KM412_08755	COG0114	fumarate hydratase activity
KM412_08780	COG3340	Belongs to the peptidase S51 family
KM412_08800	COG0785	Cytochrome C biogenesis protein
KM412_08830	COG2733	membrane
KM412_08865	COG1131	(ABC) transporter
KM412_08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM412_08885	COG0528	UMP kinase activity
KM412_08895	COG1027	Aspartate ammonia-lyase
KM412_08900	COG0281	malic enzyme
KM412_08905	COG4191	Histidine kinase
KM412_08910	COG0784	Response regulator, receiver
KM412_08915	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM412_08970	COG1051	belongs to the nudix hydrolase family
KM412_08975	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM412_08985	COG2814	Major facilitator Superfamily
KM412_09000	COG1966	Carbon starvation protein
KM412_09015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM412_09035	COG2223	nitrite transmembrane transporter activity
KM412_09040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM412_09055	COG2244	polysaccharide biosynthetic process
KM412_09060	COG0733	neurotransmitter:sodium symporter activity
KM412_09070	COG5566	PFAM Mor transcription activator
KM412_09075	COG2323	membrane
KM412_09090	COG2084	Dehydrogenase
KM412_09105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM412_09115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM412_09120	COG0028	Belongs to the TPP enzyme family
KM412_09125	COG0440	acetolactate synthase activity
KM412_09130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM412_09140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM412_09165	COG2814	Major facilitator Superfamily
KM412_09170	COG3384	dioxygenase
KM412_09180	COG3279	Response regulator of the LytR AlgR family
KM412_09185	COG0427	acetyl-CoA hydrolase
KM412_09205	COG1073	alpha beta
KM412_09235	COG0535	radical SAM domain protein
KM412_09240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_09260	COG1914	H( )-stimulated, divalent metal cation uptake system
KM412_09275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM412_09305	COG2390	Transcriptional regulator
KM412_09315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_09320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM412_09335	COG4224	UPF0291 protein
KM412_09355	COG0006	proline dipeptidase activity
KM412_09360	COG2132	Multicopper oxidase
KM412_09375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM412_09390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM412_09405	COG2372	response to copper ion
KM412_09405	COG1276	copper resistance
KM412_09410	COG4549	nuclear export factor GLE1
KM412_09420	COG0697	spore germination
KM412_09425	COG0583	DNA-binding transcription factor activity
KM412_09430	COG1959	2 iron, 2 sulfur cluster binding
KM412_09435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM412_09440	COG0778	Nitroreductase
KM412_09450	COG0628	permease
KM412_09460	COG1231	oxidoreductase activity
KM412_09465	COG0523	cobalamin synthesis protein
KM412_09480	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_09485	COG2030	dehydratase
KM412_09490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_09500	COG0411	ABC transporter
KM412_09520	COG0583	DNA-binding transcription factor activity
KM412_09530	COG1942	4-Oxalocrotonate Tautomerase
KM412_09540	COG1846	Transcriptional regulator
KM412_09550	COG1271	oxidase subunit
KM412_09555	COG1294	oxidase, subunit
KM412_09560	COG4988	ABC transporter
KM412_09565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM412_09585	COG1686	Belongs to the peptidase S11 family
KM412_09600	COG0791	NLP P60 protein
KM412_09600	COG1388	LysM domain
KM412_09615	COG0745	RESPONSE REGULATOR receiver
KM412_09620	COG5002	protein histidine kinase activity
KM412_09630	COG0300	oxidoreductase activity
KM412_09665	COG0460	homoserine dehydrogenase
KM412_09690	COG1316	TRANSCRIPTIONal
KM412_09700	COG0745	RESPONSE REGULATOR receiver
KM412_09705	COG5002	protein histidine kinase activity
KM412_09720	COG1285	pathogenesis
KM412_09725	COG1247	-acetyltransferase
KM412_09745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM412_09755	COG1082	Xylose isomerase domain protein TIM barrel
KM412_09770	COG1279	arginine transmembrane transporter activity
KM412_09780	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM412_09820	COG2002	toxin-antitoxin pair type II binding
KM412_09825	COG1404	Belongs to the peptidase S8 family
KM412_09830	COG0640	Transcriptional regulator
KM412_09835	COG0667	Aldo Keto reductase
KM412_09840	COG2814	Major facilitator Superfamily
KM412_09865	COG0840	transmembrane signaling receptor activity
KM412_09880	COG3949	Membrane
KM412_09885	COG0783	Belongs to the Dps family
KM412_09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM412_09910	COG1231	oxidoreductase activity
KM412_09920	COG4989	oxidoreductase activity
KM412_09925	COG0523	cobalamin synthesis protein
KM412_09930	COG0456	acetyltransferase
KM412_09985	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM412_09985	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM412_09995	COG0702	epimerase
KM412_10005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM412_10015	COG4166	transmembrane transport
KM412_10030	COG0406	alpha-ribazole phosphatase activity
KM412_10040	COG5337	Spore coat protein CotH
KM412_10045	COG1051	belongs to the nudix hydrolase family
KM412_10050	COG0586	Pfam SNARE associated Golgi protein
KM412_10055	COG2244	polysaccharide biosynthetic process
KM412_10065	COG0701	Predicted permease
KM412_10070	COG3689	TIGRFAM TIGR03943 family protein
KM412_10075	COG1607	acyl-coa hydrolase
KM412_10085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM412_10100	COG0702	epimerase
KM412_10105	COG2839	Protein conserved in bacteria
KM412_10110	COG1253	flavin adenine dinucleotide binding
KM412_10125	COG1114	Component of the transport system for branched-chain amino acids
KM412_10130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM412_10150	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM412_10160	COG1876	peptidase activity
KM412_10170	COG0154	amidase activity
KM412_10175	COG2211	Major facilitator Superfamily
KM412_10195	COG0561	phosphatase activity
KM412_10205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM412_10210	COG4106	trans-aconitate 2-methyltransferase activity
KM412_10225	COG1819	glycosyl
KM412_10230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_10235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_10260	COG0456	acetyltransferase
KM412_10310	COG3874	Sporulation protein YtfJ
KM412_10335	COG2226	methyltransferase
KM412_10360	COG0346	lactoylglutathione lyase activity
KM412_10370	COG0604	alcohol dehydrogenase
KM412_10375	COG1595	DNA-templated transcription, initiation
KM412_10400	COG0386	Belongs to the glutathione peroxidase family
KM412_10405	COG1305	Transglutaminase-like
KM412_10410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM412_10415	COG0714	Associated with various cellular activities
KM412_10430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM412_10435	COG1140	nitrate reductase beta subunit
KM412_10440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM412_10445	COG2181	nitrate reductase activity
KM412_10465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM412_10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM412_10475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM412_10480	COG0303	'Molybdopterin
KM412_10485	COG0314	molybdopterin synthase activity
KM412_10495	COG2223	nitrite transmembrane transporter activity
KM412_10510	COG1648	precorrin-2 dehydrogenase activity
KM412_10520	COG1587	Uroporphyrinogen-III synthase
KM412_10520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM412_10525	COG2146	nitrite reductase [NAD(P)H] activity
KM412_10530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM412_10535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM412_10570	COG2359	stage V sporulation protein S
KM412_10585	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM412_10600	COG1418	mRNA catabolic process
KM412_10605	COG0488	(ABC) transporter
KM412_10620	COG0629	single-stranded DNA binding
KM412_10635	COG1413	lyase activity
KM412_10650	COG2136	Putative SAM-dependent methyltransferase
KM412_10650	COG2521	methyltransferase
KM412_10655	COG0018	arginyl-trna synthetase
KM412_10680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM412_10700	COG0017	Asparaginyl-tRNA synthetase
KM412_10720	COG1674	ftsk spoiiie
KM412_10790	COG1929	Belongs to the glycerate kinase type-1 family
KM412_10795	COG0471	metal ion transport
KM412_10800	COG0745	RESPONSE REGULATOR receiver
KM412_10805	COG3850	Histidine kinase
KM412_10805	COG5002	protein histidine kinase activity
KM412_10820	COG0733	neurotransmitter:sodium symporter activity
KM412_10845	COG2610	gluconate transmembrane transporter activity
KM412_10850	COG1454	alcohol dehydrogenase
KM412_10855	COG1794	racemase activity, acting on amino acids and derivatives
KM412_10865	COG0456	acetyltransferase
KM412_10880	COG1131	(ABC) transporter
KM412_10895	COG0546	phosphoglycolate phosphatase activity
KM412_10915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM412_10930	COG0768	penicillin binding
KM412_10935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM412_10940	COG0204	Acyl-transferase
KM412_10945	COG1272	protein, Hemolysin III
KM412_10955	COG0805	protein transport
KM412_10965	COG1307	EDD domain protein, DegV family
KM412_10970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM412_10975	COG1999	signal sequence binding
KM412_10980	COG0071	Belongs to the small heat shock protein (HSP20) family
KM412_10985	COG0367	asparagine synthase
KM412_11000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_11005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM412_11030	COG1051	belongs to the nudix hydrolase family
KM412_11040	COG0668	transmembrane transport
KM412_11045	COG4585	Histidine kinase
KM412_11045	COG2203	Gaf domain
KM412_11050	COG2197	response regulator
KM412_11060	COG1064	alcohol dehydrogenase
KM412_11085	COG1070	Carbohydrate kinase
KM412_11090	COG1070	Carbohydrate kinase
KM412_11120	COG1125	glycine betaine transport
KM412_11120	COG0517	IMP dehydrogenase activity
KM412_11125	COG1174	glycine betaine transport
KM412_11160	COG1253	flavin adenine dinucleotide binding
KM412_11165	COG1012	belongs to the aldehyde dehydrogenase family
KM412_11170	COG5506	Protein of unknown function (DUF1694)
KM412_11185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM412_11190	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM412_11195	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM412_11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM412_11205	COG0456	acetyltransferase
KM412_11210	COG3829	transcription factor binding
KM412_11215	COG1509	lysine 2,3-aminomutase activity
KM412_11255	COG4326	sporulation control protein
KM412_11260	COG0671	phosphoesterase, PA-phosphatase related
KM412_11265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM412_11270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM412_11300	COG1715	Restriction endonuclease
KM412_11300	COG1787	Restriction endonuclease
KM412_11390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM412_11430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM412_11430	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM412_11435	COG2814	Major facilitator Superfamily
KM412_11440	COG4841	protein insertion into membrane
KM412_11445	COG0372	Belongs to the citrate synthase family
KM412_11450	COG2079	MmgE PrpD family protein
KM412_11455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM412_11460	COG1960	acyl-CoA dehydrogenase activity
KM412_11465	COG2084	Dehydrogenase
KM412_11475	COG1280	lysine exporter protein (LysE YggA)
KM412_11480	COG1024	Enoyl-CoA hydratase
KM412_11495	COG0420	3'-5' exonuclease activity
KM412_11500	COG0419	ATPase involved in DNA repair
KM412_11520	COG2223	nitrite transmembrane transporter activity
KM412_11525	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_11530	COG1169	isochorismate synthase
KM412_11535	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM412_11540	COG1535	isochorismatase
KM412_11540	COG3433	isochorismatase activity
KM412_11545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM412_11550	COG3251	PFAM MbtH domain protein
KM412_11555	COG2814	Major facilitator Superfamily
KM412_11570	COG0776	regulation of translation
KM412_11580	COG2318	DinB family
KM412_11590	COG1115	amino acid carrier protein
KM412_11605	COG2329	Antibiotic biosynthesis monooxygenase
KM412_11610	COG1187	pseudouridine synthase activity
KM412_11615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM412_11630	COG0596	Alpha beta hydrolase
KM412_11635	COG2814	Major facilitator Superfamily
KM412_11655	COG2226	methyltransferase
KM412_11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_11735	COG1247	-acetyltransferase
KM412_11765	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM412_11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_11785	COG1278	Cold shock
KM412_11800	COG0010	Belongs to the arginase family
KM412_11805	COG0561	phosphatase activity
KM412_11850	COG0583	DNA-binding transcription factor activity
KM412_11855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM412_11870	COG0583	DNA-binding transcription factor activity
KM412_11875	COG2258	MOSC domain
KM412_11890	COG1132	(ABC) transporter
KM412_11895	COG1132	(ABC) transporter
KM412_11915	COG1396	sequence-specific DNA binding
KM412_11940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM412_11945	COG1595	DNA-templated transcription, initiation
KM412_11970	COG1649	PFAM Uncharacterised BCR, COG1649
KM412_11995	COG2971	BadF BadG BcrA BcrD
KM412_12000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM412_12005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM412_12025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_12055	COG1309	transcriptional regulator
KM412_12070	COG0577	efflux transmembrane transporter activity
KM412_12070	COG1136	(ABC) transporter
KM412_12075	COG0500	methyltransferase
KM412_12075	COG3615	Tellurite resistance protein tehB
KM412_12085	COG2226	methyltransferase
KM412_12090	COG3961	Belongs to the TPP enzyme family
KM412_12095	COG1846	Transcriptional regulator
KM412_12135	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM412_12150	COG1595	DNA-templated transcription, initiation
KM412_12160	COG0768	penicillin binding
KM412_12170	COG2367	Beta-lactamase
KM412_12175	COG0671	phosphoesterase, PA-phosphatase related
KM412_12180	COG1609	Transcriptional regulator
KM412_12185	COG2814	Major facilitator Superfamily
KM412_12190	COG0673	inositol 2-dehydrogenase activity
KM412_12200	COG1012	belongs to the aldehyde dehydrogenase family
KM412_12215	COG0191	fructose-bisphosphate aldolase activity
KM412_12220	COG3718	enzyme involved in inositol metabolism
KM412_12245	COG0457	Tetratricopeptide repeat
KM412_12250	COG1476	TRANSCRIPTIONal
KM412_12265	COG1876	peptidase activity
KM412_12285	COG1309	transcriptional regulator
KM412_12290	COG0488	(ABC) transporter
KM412_12305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_12320	COG1252	NADH dehydrogenase
KM412_12325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_12340	COG1131	(ABC) transporter
KM412_12350	COG1309	transcriptional regulator
KM412_12365	COG1960	acyl-CoA dehydrogenase activity
KM412_12370	COG0439	Biotin carboxylase
KM412_12375	COG0511	ligase activity, forming carbon-carbon bonds
KM412_12380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM412_12385	COG1024	Enoyl-CoA hydratase
KM412_12390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM412_12395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM412_12405	COG1247	-acetyltransferase
KM412_12410	COG0572	uridine kinase
KM412_12420	COG2318	DinB family
KM412_12425	COG1686	Belongs to the peptidase S11 family
KM412_12450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM412_12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM412_12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM412_12515	COG2814	Major facilitator Superfamily
KM412_12535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM412_12555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_12570	COG1063	alcohol dehydrogenase
KM412_12600	COG3773	Cell wall hydrolase
KM412_12610	COG0745	RESPONSE REGULATOR receiver
KM412_12625	COG0488	(ABC) transporter
KM412_12640	COG1136	(ABC) transporter
KM412_12665	COG0460	homoserine dehydrogenase
KM412_12670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_12680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM412_12745	COG2124	cytochrome p450
KM412_12780	COG0561	phosphatase activity
KM412_12790	COG5002	protein histidine kinase activity
KM412_12795	COG0768	penicillin binding
KM412_12800	COG1819	glycosyl
KM412_12805	COG1794	racemase activity, acting on amino acids and derivatives
KM412_12815	COG1122	ATPase activity
KM412_12830	COG2205	protein histidine kinase activity
KM412_12840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM412_12845	COG0604	alcohol dehydrogenase
KM412_12850	COG0768	penicillin binding
KM412_12860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM412_12895	COG0693	protein deglycase activity
KM412_12925	COG2814	Major facilitator Superfamily
KM412_12940	COG0584	glycerophosphoryl diester phosphodiesterase
KM412_12960	COG0697	spore germination
KM412_12985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM412_12995	COG2223	nitrite transmembrane transporter activity
KM412_13010	COG2816	NAD+ diphosphatase activity
KM412_13015	COG0592	DNA-directed DNA polymerase activity
KM412_13020	COG1051	belongs to the nudix hydrolase family
KM412_13055	COG3878	Protein conserved in bacteria
KM412_13100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM412_13115	COG0322	excinuclease ABC activity
KM412_13155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM412_13180	COG1011	Hydrolase
KM412_13200	COG0076	glutamate decarboxylase activity
KM412_13215	COG1523	belongs to the glycosyl hydrolase 13 family
KM412_13220	COG3227	Zinc metalloprotease (Elastase)
KM412_13240	COG0201	protein transport
KM412_13250	COG0697	spore germination
KM412_13255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_13285	COG4129	membrane
KM412_13290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_13305	COG2959	enzyme of heme biosynthesis
KM412_13325	COG3483	tryptophan 2,3-dioxygenase activity
KM412_13330	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM412_13335	COG3844	kynureninase activity
KM412_13340	COG1309	transcriptional regulator
KM412_13370	COG3284	Transcriptional regulator
KM412_13390	COG1349	DNA-binding transcription factor activity
KM412_13410	COG1959	2 iron, 2 sulfur cluster binding
KM412_13425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM412_13430	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM412_13435	COG0022	dehydrogenase e1 component
KM412_13440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM412_13450	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_13455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM412_13455	COG0456	acetyltransferase
KM412_13485	COG4176	ABC-type proline glycine betaine transport system permease component
KM412_13490	COG0517	IMP dehydrogenase activity
KM412_13490	COG4175	Glycine betaine
KM412_13515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM412_13520	COG2153	protein acetylation
KM412_13525	COG3397	chitin binding
KM412_13540	COG2205	protein histidine kinase activity
KM412_13565	COG0658	competence protein
KM412_13565	COG2333	competence protein COMEC
KM412_13615	COG3973	AAA domain
KM412_13630	COG2105	PFAM AIG2 family protein
KM412_13635	COG0514	ATP-dependent DNA helicase (RecQ)
KM412_13655	COG4637	Psort location Cytoplasmic, score
KM412_13680	COG3397	chitin binding
KM412_13695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM412_13700	COG1115	amino acid carrier protein
KM412_13705	COG1012	belongs to the aldehyde dehydrogenase family
KM412_13710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM412_13720	COG3938	Belongs to the proline racemase family
KM412_13725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM412_13765	COG0586	Pfam SNARE associated Golgi protein
KM412_13780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM412_13785	COG0519	Catalyzes the synthesis of GMP from XMP
KM412_13790	COG4166	transmembrane transport
KM412_13800	COG4948	Mandelate Racemase Muconate Lactonizing
KM412_13845	COG2936	dipeptidyl-peptidase activity
KM412_13850	COG5002	protein histidine kinase activity
KM412_13890	COG1164	Oligoendopeptidase f
KM412_13905	COG1307	EDD domain protein, DegV family
KM412_13925	COG2814	Major facilitator Superfamily
KM412_13935	COG1664	Polymer-forming cytoskeletal
KM412_13940	COG0789	Transcriptional regulator
KM412_13945	COG4533	DNA binding
KM412_13950	COG0477	Major facilitator Superfamily
KM412_13950	COG2814	Major facilitator Superfamily
KM412_13970	COG2261	transglycosylase associated protein
KM412_13985	COG2226	methyltransferase
KM412_14020	COG0436	Aminotransferase
KM412_14025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM412_14030	COG5146	pantothenate kinase activity
KM412_14050	COG1131	(ABC) transporter
KM412_14095	COG0628	permease
KM412_14105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM412_14110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM412_14115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM412_14120	COG1116	anion transmembrane transporter activity
KM412_14140	COG2816	NAD+ diphosphatase activity
KM412_14160	COG2746	aminoglycoside 3-N-acetyltransferase activity
KM412_14185	COG0697	spore germination
KM412_14190	COG2318	DinB family
KM412_14210	COG4912	Dna alkylation repair
KM412_14230	COG0861	Integral membrane protein TerC family
KM412_14235	COG1368	sulfuric ester hydrolase activity
KM412_14240	COG0488	(ABC) transporter
KM412_14250	COG1033	growth of symbiont in host cell
KM412_14250	COG2409	Drug exporters of the RND superfamily
KM412_14255	COG1033	growth of symbiont in host cell
KM412_14255	COG2409	Drug exporters of the RND superfamily
KM412_14260	COG1033	growth of symbiont in host cell
KM412_14260	COG2409	Drug exporters of the RND superfamily
KM412_14265	COG1309	transcriptional regulator
KM412_14280	COG0287	Prephenate dehydrogenase
KM412_14285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM412_14290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM412_14295	COG1605	Chorismate mutase
KM412_14295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM412_14330	COG1388	LysM domain
KM412_14330	COG3584	3D domain protein
KM412_14340	COG1595	DNA-templated transcription, initiation
KM412_14365	COG1879	ABC-type sugar transport system periplasmic component
KM412_14375	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM412_14385	COG2390	Transcriptional regulator
KM412_14420	COG2329	Antibiotic biosynthesis monooxygenase
KM412_14440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_14450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM412_14455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM412_14460	COG4187	Peptidase family M20/M25/M40
KM412_14465	COG1414	Transcriptional regulator
KM412_14470	COG0833	amino acid
KM412_14475	COG1690	Belongs to the RtcB family
KM412_14480	COG3239	Fatty acid desaturase
KM412_14485	COG1785	Belongs to the alkaline phosphatase family
KM412_14495	COG3655	Transcriptional regulator
KM412_14510	COG4377	Putative membrane peptidase family (DUF2324)
KM412_14520	COG3279	Response regulator of the LytR AlgR family
KM412_14530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_14535	COG0346	lactoylglutathione lyase activity
KM412_14555	COG0714	Associated with various cellular activities
KM412_14580	COG0463	Glycosyl transferase, family 2
KM412_14605	COG0463	Glycosyl transferase, family 2
KM412_14615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM412_14620	COG0753	catalase activity
KM412_14630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM412_14655	COG0714	Associated with various cellular activities
KM412_14665	COG0778	Nitroreductase
KM412_14670	COG1846	Transcriptional regulator
KM412_14705	COG1725	Transcriptional regulator
KM412_14715	COG0577	efflux transmembrane transporter activity
KM412_14715	COG1136	(ABC) transporter
KM412_14740	COG2207	Transcriptional regulator
KM412_14745	COG0456	acetyltransferase
KM412_14765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_14785	COG0642	Histidine kinase
KM412_14790	COG0745	RESPONSE REGULATOR receiver
KM412_14795	COG0596	Alpha beta hydrolase
KM412_14825	COG0730	response to heat
KM412_14835	COG0833	amino acid
KM412_14845	COG4335	DNA alkylation repair
KM412_14885	COG0768	penicillin binding
KM412_14895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM412_14925	COG1984	allophanate hydrolase subunit 2
KM412_14930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM412_14935	COG1414	Transcriptional regulator
KM412_14950	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM412_14955	COG0640	Transcriptional regulator
KM412_14965	COG1960	acyl-CoA dehydrogenase activity
KM412_14980	COG3314	Sporulation integral membrane protein YlbJ
KM412_14995	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM412_15010	COG0574	Belongs to the PEP-utilizing enzyme family
KM412_15010	COG3848	Pyruvate phosphate dikinase
KM412_15015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_15030	COG5577	PFAM Coat F domain
KM412_15035	COG3403	YqcI/YcgG family
KM412_15040	COG1280	lysine exporter protein (LysE YggA)
KM412_15075	COG1063	alcohol dehydrogenase
KM412_15090	COG1027	Aspartate ammonia-lyase
KM412_15095	COG0252	asparaginase activity
KM412_15100	COG1396	sequence-specific DNA binding
KM412_15110	COG0322	excinuclease ABC activity
KM412_15115	COG0531	amino acid
KM412_15120	COG1114	Component of the transport system for branched-chain amino acids
KM412_15125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM412_15135	COG0281	malic enzyme
KM412_15150	COG0531	amino acid
KM412_15160	COG0784	Response regulator, receiver
KM412_15170	COG2066	Belongs to the glutaminase family
KM412_15175	COG1115	amino acid carrier protein
KM412_15205	COG0737	Belongs to the 5'-nucleotidase family
KM412_15210	COG0753	catalase activity
KM412_15215	COG2267	carboxylic ester hydrolase activity
KM412_15220	COG1335	isochorismatase
KM412_15240	COG0583	DNA-binding transcription factor activity
KM412_15245	COG1846	Transcriptional regulator
KM412_15285	COG0415	Belongs to the DNA photolyase family
KM412_15290	COG0288	reversible hydration of carbon dioxide
KM412_15300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM412_15305	COG5609	conserved protein (DUF2294)
KM412_15320	COG1575	Belongs to the MenA family. Type 1 subfamily
KM412_15325	COG2267	carboxylic ester hydrolase activity
KM412_15330	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM412_15335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM412_15340	COG1121	(ABC) transporter
KM412_15370	COG0798	PFAM Bile acid sodium symporter
KM412_15375	COG0346	lactoylglutathione lyase activity
KM412_15380	COG0640	Transcriptional regulator
KM412_15395	COG0443	Heat shock 70 kDa protein
KM412_15410	COG1522	sequence-specific DNA binding
KM412_15425	COG0346	lactoylglutathione lyase activity
KM412_15450	COG2169	Transcriptional regulator
KM412_15495	COG2814	Major facilitator Superfamily
KM412_15520	COG0745	RESPONSE REGULATOR receiver
KM412_15525	COG5002	protein histidine kinase activity
KM412_15525	COG3850	Histidine kinase
KM412_15550	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM412_15570	COG1476	TRANSCRIPTIONal
KM412_15585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_15590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM412_15600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_15605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM412_15620	COG1136	(ABC) transporter
KM412_15625	COG0577	efflux transmembrane transporter activity
KM412_15640	COG3850	Histidine kinase
KM412_15640	COG5002	protein histidine kinase activity
KM412_15650	COG2364	Membrane
KM412_15655	COG1846	Transcriptional regulator
KM412_15665	COG2808	Putative FMN-binding domain
KM412_15670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_15675	COG2271	Major facilitator Superfamily
KM412_15680	COG1556	Lactate utilization protein
KM412_15685	COG1139	Iron-sulfur cluster binding protein
KM412_15695	COG0583	DNA-binding transcription factor activity
KM412_15705	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM412_15725	COG0738	Major facilitator superfamily
KM412_15730	COG0673	inositol 2-dehydrogenase activity
KM412_15735	COG0561	phosphatase activity
KM412_15745	COG1609	Transcriptional regulator
KM412_15750	COG0457	Tetratricopeptide repeat
KM412_15770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM412_15800	COG0534	Mate efflux family protein
KM412_15820	COG2814	Major facilitator Superfamily
KM412_15825	COG1309	transcriptional regulator
KM412_15840	COG0814	amino acid
KM412_15845	COG1760	l-serine dehydratase
KM412_15850	COG1760	l-serine dehydratase
KM412_15860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM412_15865	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM412_15875	COG1335	isochorismatase
KM412_15880	COG1522	sequence-specific DNA binding
KM412_15885	COG0531	amino acid
KM412_15900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM412_15920	COG1595	DNA-templated transcription, initiation
KM412_15935	COG0662	Cupin 2, conserved barrel domain protein
KM412_15940	COG2207	Transcriptional regulator
KM412_15940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_15990	COG0477	Major facilitator Superfamily
KM412_16000	COG1846	Transcriptional regulator
KM412_16005	COG2814	Major facilitator Superfamily
KM412_16015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM412_16020	COG1131	(ABC) transporter
KM412_16040	COG2076	Multidrug Resistance protein
KM412_16045	COG1309	transcriptional regulator
KM412_16055	COG2031	fatty acid transporter
KM412_16065	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM412_16095	COG1122	ATPase activity
KM412_16100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM412_16115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM412_16120	COG1288	antiporter activity
KM412_16125	COG2356	endonuclease I
KM412_16140	COG3620	sequence-specific DNA binding
KM412_16145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM412_16150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM412_16155	COG0124	histidyl-tRNA synthetase
KM412_16170	COG1733	regulation of RNA biosynthetic process
KM412_16175	COG0778	Nitroreductase
KM412_16195	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_16205	COG1131	(ABC) transporter
KM412_16230	COG1011	Hydrolase
KM412_16240	COG2365	Tyrosine phosphatase family
KM412_16265	COG0346	lactoylglutathione lyase activity
KM412_16270	COG1940	carbohydrate kinase activity
KM412_16275	COG0738	Major facilitator superfamily
KM412_16280	COG0110	maltose O-acetyltransferase activity
KM412_16290	COG0577	efflux transmembrane transporter activity
KM412_16290	COG1136	(ABC) transporter
KM412_16305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM412_16310	COG0628	permease
KM412_16330	COG2226	methyltransferase
KM412_16340	COG0477	Major facilitator Superfamily
KM412_16370	COG1253	flavin adenine dinucleotide binding
KM412_16375	COG0789	Transcriptional regulator
KM412_16380	COG0697	spore germination
KM412_16385	COG1357	PFAM Pentapeptide repeats (8 copies)
KM412_16390	COG3813	Protein conserved in bacteria
KM412_16395	COG2706	6-phosphogluconolactonase activity
KM412_16400	COG1070	Carbohydrate kinase
KM412_16410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM412_16415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM412_16425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM412_16430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM412_16435	COG0604	alcohol dehydrogenase
KM412_16440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM412_16450	COG0604	alcohol dehydrogenase
KM412_16450	COG3321	synthase
KM412_16455	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_16480	COG0656	L-ascorbic acid biosynthetic process
KM412_16485	COG2814	Major facilitator Superfamily
KM412_16500	COG0346	lactoylglutathione lyase activity
KM412_16505	COG0814	amino acid
KM412_16530	COG1393	Belongs to the ArsC family
KM412_16535	COG1733	regulation of RNA biosynthetic process
KM412_16540	COG2188	Transcriptional regulator
KM412_16550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM412_16555	COG1733	regulation of RNA biosynthetic process
KM412_16560	COG1733	regulation of RNA biosynthetic process
KM412_16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_16595	COG0384	phenazine biosynthesis protein PhzF
KM412_16605	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_16615	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_16625	COG1733	regulation of RNA biosynthetic process
KM412_16660	COG1191	sigma factor activity
KM412_16675	COG1309	transcriptional regulator
KM412_16695	COG3152	Membrane
KM412_16720	COG1151	hydroxylamine reductase activity
KM412_16730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_16735	COG3409	Peptidoglycan-binding domain 1 protein
KM412_16735	COG3757	hydrolase, family 25
KM412_16770	COG2072	flavoprotein involved in K transport
KM412_16805	COG0604	alcohol dehydrogenase
KM412_16810	COG1113	amino acid transport
KM412_16815	COG2814	Major facilitator Superfamily
KM412_16845	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM412_16850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM412_16870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_16880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_16885	COG3739	integral membrane protein
KM412_16890	COG0384	phenazine biosynthesis protein PhzF
KM412_16920	COG0583	DNA-binding transcription factor activity
KM412_16940	COG1193	negative regulation of DNA recombination
KM412_16965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM412_16995	COG0584	glycerophosphoryl diester phosphodiesterase
KM412_17020	COG0640	Transcriptional regulator
KM412_17025	COG0604	alcohol dehydrogenase
KM412_17045	COG2808	Putative FMN-binding domain
KM412_17050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM412_17060	COG0385	Bile acid
KM412_17065	COG0277	FAD linked oxidase domain protein
KM412_17095	COG1216	Glycosyl transferase, family 2
KM412_17100	COG1024	Enoyl-CoA hydratase
KM412_17110	COG1285	pathogenesis
KM412_17125	COG2514	catechol 2,3-dioxygenase activity
KM412_17130	COG2720	vancomycin resistance protein
KM412_17170	COG0716	FMN binding
KM412_17200	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_17210	COG0165	Argininosuccinate lyase
KM412_17225	COG4145	pantothenate transmembrane transporter activity
KM412_17235	COG1012	belongs to the aldehyde dehydrogenase family
KM412_17240	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_17250	COG1657	PFAM Prenyltransferase squalene oxidase
KM412_17255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM412_17260	COG2962	Rard protein
KM412_17265	COG3326	Membrane
KM412_17280	COG0489	protein tyrosine kinase activity
KM412_17290	COG0314	molybdopterin synthase activity
KM412_17295	COG0303	'Molybdopterin
KM412_17300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM412_17305	COG2116	formate transmembrane transporter activity
KM412_17315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM412_17320	COG5609	conserved protein (DUF2294)
KM412_17325	COG2427	Protein of unknown function (DUF1641)
KM412_17330	COG3383	formate dehydrogenase (NAD+) activity
KM412_17335	COG0697	spore germination
KM412_17375	COG2226	methyltransferase
KM412_17380	COG4166	transmembrane transport
KM412_17385	COG4166	transmembrane transport
KM412_17390	COG4166	transmembrane transport
KM412_17395	COG1301	dicarboxylic acid transport
KM412_17400	COG1316	TRANSCRIPTIONal
KM412_17410	COG1595	DNA-templated transcription, initiation
KM412_17430	COG1131	(ABC) transporter
KM412_17440	COG0673	inositol 2-dehydrogenase activity
KM412_17445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM412_17450	COG0187	DNA topoisomerase II activity
KM412_17455	COG1832	CoA-binding protein
KM412_17460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM412_17465	COG0745	RESPONSE REGULATOR receiver
KM412_17480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM412_17485	COG4841	protein insertion into membrane
KM412_17490	COG0824	Thioesterase
KM412_17520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM412_17530	COG2274	protein secretion by the type I secretion system
KM412_17535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM412_17575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM412_17590	COG0183	Belongs to the thiolase family
KM412_17595	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_17600	COG1268	BioY protein
KM412_17605	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_17655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_17665	COG5002	protein histidine kinase activity
KM412_17670	COG0400	carboxylic ester hydrolase activity
KM412_17675	COG0346	lactoylglutathione lyase activity
KM412_17680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM412_17685	COG0069	glutamate synthase activity
KM412_17690	COG1902	pentaerythritol trinitrate reductase activity
KM412_17695	COG1329	Transcriptional regulator
KM412_17700	COG0010	Belongs to the arginase family
KM412_17725	COG2226	methyltransferase
KM412_17780	COG4846	Membrane protein involved in cytochrome C biogenesis
KM412_17785	COG0785	Cytochrome C biogenesis protein
KM412_17795	COG0583	DNA-binding transcription factor activity
KM412_17800	COG1380	Effector of murein hydrolase LrgA
KM412_17805	COG1346	cytolysis
KM412_17830	COG3409	Peptidoglycan-binding domain 1 protein
KM412_17830	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM412_17845	COG1132	(ABC) transporter
KM412_17850	COG1132	(ABC) transporter
KM412_17880	COG3639	organic phosphonate transmembrane transporter activity
KM412_17885	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM412_17905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM412_17925	COG1695	Transcriptional regulator
KM412_17960	COG1388	LysM domain
KM412_17960	COG3409	Peptidoglycan-binding domain 1 protein
KM412_17960	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM412_17965	COG4824	toxin secretion phage lysis holin
KM412_18120	COG1595	DNA-templated transcription, initiation
KM412_18165	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM412_18245	COG1396	sequence-specific DNA binding
KM412_18270	COG0174	glutamine synthetase
KM412_18275	COG0789	Transcriptional regulator
KM412_18280	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM412_18290	COG2860	membrane
KM412_18300	COG0464	growth
KM412_18330	COG3584	3D domain protein
KM412_18330	COG1388	LysM domain
KM412_18335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM412_18335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM412_18335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM412_18340	COG1105	Belongs to the carbohydrate kinase PfkB family
KM412_18345	COG1349	DNA-binding transcription factor activity
KM412_18355	COG2322	membrane
KM412_18365	COG1113	amino acid transport
KM412_18380	COG1408	metallophosphoesterase
KM412_18385	COG2116	formate transmembrane transporter activity
KM412_18395	COG2217	Heavy metal translocating P-type atpase
KM412_18400	COG2608	mercury ion transmembrane transporter activity
KM412_18405	COG1937	Protein conserved in bacteria
KM412_18415	COG2819	hydrolase of the alpha beta superfamily
KM412_18420	COG1120	ATPase activity
KM412_18425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_18430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_18440	COG0708	Exodeoxyribonuclease III
KM412_18445	COG2169	Transcriptional regulator
KM412_18450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM412_18455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM412_18465	COG2364	Membrane
KM412_18480	COG2267	carboxylic ester hydrolase activity
KM412_18485	COG0346	lactoylglutathione lyase activity
KM412_18490	COG3300	MHYT domain
KM412_18490	COG5001	Diguanylate cyclase
KM412_18505	COG1346	cytolysis
KM412_18510	COG1380	Effector of murein hydrolase LrgA
KM412_18515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM412_18520	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM412_18520	COG0596	Alpha beta hydrolase
KM412_18525	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM412_18545	COG1404	Belongs to the peptidase S8 family
KM412_18550	COG3773	Cell wall hydrolase
KM412_18555	COG0562	UDP-galactopyranose mutase
KM412_18560	COG1368	sulfuric ester hydrolase activity
KM412_18565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM412_18575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM412_18600	COG1131	(ABC) transporter
KM412_18620	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM412_18625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM412_18630	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM412_18635	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM412_18635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM412_18645	COG2359	stage V sporulation protein S
KM412_18650	COG1692	metallophosphoesterase
KM412_18675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM412_18680	COG1426	Protein conserved in bacteria
KM412_18695	COG0300	oxidoreductase activity
KM412_18700	COG0612	Peptidase, M16
KM412_18705	COG0612	Peptidase, M16
KM412_18710	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM412_18720	COG3845	ABC transporter
KM412_18725	COG1744	ABC transporter substrate-binding protein PnrA-like
KM412_18730	COG2188	Transcriptional regulator
KM412_18735	COG1674	ftsk spoiiie
KM412_18745	COG0740	serine-type endopeptidase activity
KM412_18750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM412_18765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM412_18770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM412_18775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM412_18780	COG1873	PFAM PRC-barrel domain
KM412_18785	COG0612	Peptidase, M16
KM412_18790	COG0726	polysaccharide deacetylase
KM412_18805	COG0196	riboflavin kinase activity
KM412_18810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM412_18820	COG1550	Protein conserved in bacteria
KM412_18830	COG1358	cellular component organization or biogenesis
KM412_18835	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM412_18840	COG0195	Participates in both transcription termination and antitermination
KM412_18860	COG0750	zinc metalloprotease
KM412_18870	COG4589	Belongs to the CDS family
KM412_18875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM412_18885	COG0528	UMP kinase activity
KM412_18915	COG4974	Belongs to the 'phage' integrase family
KM412_18925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM412_18935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM412_18975	COG1837	Belongs to the UPF0109 family
KM412_18985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM412_18995	COG0552	protein localization to endoplasmic reticulum
KM412_19000	COG1196	nuclear chromosome segregation
KM412_19010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM412_19015	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_19020	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM412_19035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM412_19040	COG1461	Dihydroxyacetone kinase
KM412_19045	COG1302	Protein conserved in bacteria
KM412_19060	COG1564	THIamine pyrophosphokinase
KM412_19065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM412_19070	COG1162	GTPase activity
KM412_19075	COG0515	serine threonine protein kinase
KM412_19075	COG2815	serine threonine protein kinase
KM412_19080	COG0631	protein serine/threonine phosphatase activity
KM412_19090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM412_19090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM412_19100	COG0242	peptide deformylase activity
KM412_19105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM412_19110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM412_19130	COG1561	YicC-like family, N-terminal region
KM412_19135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM412_19145	COG0006	proline dipeptidase activity
KM412_19160	COG3069	C4-dicarboxylate transmembrane transporter activity
KM412_19225	COG0564	pseudouridine synthase activity
KM412_19245	COG3599	regulation of cell shape
KM412_19250	COG2302	S4 RNA-binding domain
KM412_19255	COG0762	integral membrane protein
KM412_19265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM412_19270	COG1496	oxidoreductase activity
KM412_19275	COG1873	PFAM PRC-barrel domain
KM412_19280	COG1191	sigma factor activity
KM412_19285	COG1191	sigma factor activity
KM412_19295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM412_19300	COG0849	cell division
KM412_19305	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM412_19310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM412_19320	COG0772	Belongs to the SEDS family
KM412_19335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM412_19340	COG0768	penicillin binding
KM412_19345	COG0768	penicillin binding
KM412_19350	COG4839	cell division protein FtsL
KM412_19365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM412_19380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM412_19385	COG1399	metal-binding, possibly nucleic acid-binding protein
KM412_19435	COG4824	toxin secretion phage lysis holin
KM412_19520	COG4626	Terminase
KM412_19520	COG1802	Transcriptional regulator
KM412_19545	COG0582	viral genome integration into host DNA
KM412_19610	COG0756	dUTP diphosphatase activity
KM412_19625	COG1191	sigma factor activity
KM412_19650	COG1484	DNA-dependent DNA replication
KM412_19680	COG1396	sequence-specific DNA binding
KM412_19695	COG1396	sequence-specific DNA binding
KM412_19710	COG0582	viral genome integration into host DNA
KM412_19720	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM412_19725	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM412_19730	COG3314	Sporulation integral membrane protein YlbJ
KM412_19740	COG0742	ribosomal rna small subunit methyltransferase
KM412_19755	COG3679	Belongs to the UPF0342 family
KM412_19760	COG0406	alpha-ribazole phosphatase activity
KM412_19775	COG2340	Cysteine-rich secretory protein family
KM412_19790	COG3336	cytochrome c oxidase
KM412_19825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM412_19830	COG0772	Belongs to the SEDS family
KM412_19840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM412_19845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM412_19855	COG4896	Protein conserved in bacteria
KM412_19870	COG1217	gtp-binding protein TYPA
KM412_19880	COG0483	inositol monophosphate 1-phosphatase activity
KM412_19900	COG1982	Orn Lys Arg decarboxylase major
KM412_19945	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM412_19950	COG0022	dehydrogenase e1 component
KM412_19955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM412_19965	COG0242	peptide deformylase activity
KM412_19970	COG0561	phosphatase activity
KM412_19980	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM412_19985	COG0569	domain protein
KM412_20005	COG0583	DNA-binding transcription factor activity
KM412_20010	COG0517	IMP dehydrogenase activity
KM412_20020	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM412_20030	COG4703	Protein of unknown function (DUF1797)
KM412_20045	COG2200	EAL domain
KM412_20050	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_20055	COG1408	metallophosphoesterase
KM412_20065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM412_20100	COG2814	Major facilitator Superfamily
KM412_20120	COG3209	COG3209 Rhs family protein
KM412_20130	COG2205	protein histidine kinase activity
KM412_20140	COG0436	Aminotransferase
KM412_20145	COG1609	Transcriptional regulator
KM412_20150	COG3833	ABC-type maltose transport systems, permease component
KM412_20155	COG1175	transmembrane transport
KM412_20160	COG2182	Extracellular solute-binding protein
KM412_20170	COG0366	Alpha amylase catalytic
KM412_20175	COG3842	ATPase activity
KM412_20215	COG0183	Belongs to the thiolase family
KM412_20250	COG1695	Transcriptional regulator
KM412_20255	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_20265	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM412_20275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM412_20280	COG0436	Aminotransferase
KM412_20300	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM412_20320	COG2199	diguanylate cyclase activity
KM412_20325	COG0778	Nitroreductase
KM412_20350	COG2190	(PTS) system
KM412_20350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM412_20350	COG1263	PTS System
KM412_20355	COG3711	transcriptional antiterminator
KM412_20365	COG2188	Transcriptional regulator
KM412_20375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM412_20400	COG1547	Domain of unknown function (DUF309)
KM412_20405	COG0456	acetyltransferase
KM412_20410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM412_20415	COG4086	secreted protein
KM412_20420	COG0561	phosphatase activity
KM412_20425	COG0697	spore germination
KM412_20440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_20465	COG0733	neurotransmitter:sodium symporter activity
KM412_20485	COG1686	Belongs to the peptidase S11 family
KM412_20490	COG1725	Transcriptional regulator
KM412_20495	COG1131	(ABC) transporter
KM412_20510	COG1846	Transcriptional regulator
KM412_20525	COG0598	Magnesium transport protein CorA
KM412_20550	COG4974	Belongs to the 'phage' integrase family
KM412_20560	COG0735	belongs to the Fur family
KM412_20565	COG1300	Membrane
KM412_20585	COG0667	Aldo Keto reductase
KM412_20590	COG0656	L-ascorbic acid biosynthetic process
KM412_20595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM412_20595	COG0456	acetyltransferase
KM412_20605	COG4085	toxin activity
KM412_20605	COG1525	nuclease
KM412_20605	COG0737	Belongs to the 5'-nucleotidase family
KM412_20615	COG0596	Alpha beta hydrolase
KM412_20620	COG2056	Na+-H+ antiporter family
KM412_20625	COG1609	Transcriptional regulator
KM412_20630	COG0456	acetyltransferase
KM412_20635	COG1073	alpha beta
KM412_20650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM412_20650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM412_20655	COG0307	riboflavin synthase, alpha
KM412_20680	COG4106	trans-aconitate 2-methyltransferase activity
KM412_20685	COG1073	alpha beta
KM412_20685	COG2226	methyltransferase
KM412_20700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM412_20710	COG1757	Na H antiporter
KM412_20715	COG0737	Belongs to the 5'-nucleotidase family
KM412_20725	COG1522	sequence-specific DNA binding
KM412_20745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM412_20755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM412_20770	COG0300	oxidoreductase activity
KM412_20780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM412_20785	COG1760	l-serine dehydratase
KM412_20790	COG1760	l-serine dehydratase
KM412_20810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM412_20820	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM412_20825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_20840	COG1376	ErfK ybiS ycfS ynhG family protein
KM412_20845	COG4129	membrane
KM412_20850	COG1126	abc transporter atp-binding protein
KM412_20855	COG0765	amino acid transport
KM412_20860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM412_20880	COG0772	Belongs to the SEDS family
KM412_20885	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM412_20890	COG0022	dehydrogenase e1 component
KM412_20895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM412_20900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM412_20915	COG0280	phosphate acetyltransferase
KM412_20920	COG3290	protein histidine kinase activity
KM412_20920	COG3829	transcription factor binding
KM412_20930	COG0584	glycerophosphoryl diester phosphodiesterase
KM412_20935	COG3093	addiction module antidote protein HigA
KM412_20945	COG0745	RESPONSE REGULATOR receiver
KM412_20950	COG0750	zinc metalloprotease
KM412_20955	COG0497	DNA recombination
KM412_20965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM412_20975	COG0142	geranyltranstransferase activity
KM412_21000	COG1302	Protein conserved in bacteria
KM412_21005	COG0439	Biotin carboxylase
KM412_21010	COG0511	ligase activity, forming carbon-carbon bonds
KM412_21055	COG3854	ATPases associated with a variety of cellular activities
KM412_21080	COG0006	proline dipeptidase activity
KM412_21095	COG3872	metal-dependent enzyme
KM412_21105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM412_21125	COG0095	Lipoate-protein ligase
KM412_21130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_21135	COG1609	Transcriptional regulator
KM412_21145	COG2076	Multidrug Resistance protein
KM412_21150	COG2076	Multidrug Resistance protein
KM412_21185	COG1131	(ABC) transporter
KM412_21190	COG1725	Transcriptional regulator
KM412_21220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM412_21275	COG4970	Tfp pilus assembly protein FimT
KM412_21285	COG1459	type II secretion system
KM412_21290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM412_21340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM412_21345	COG1410	methionine synthase
KM412_21345	COG0646	methionine synthase
KM412_21350	COG0646	methionine synthase
KM412_21350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM412_21355	COG0626	cystathionine gamma-synthase activity
KM412_21360	COG0626	cystathionine gamma-synthase activity
KM412_21380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_21390	COG1940	carbohydrate kinase activity
KM412_21395	COG4483	Protein conserved in bacteria
KM412_21400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM412_21405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM412_21410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM412_21415	COG0704	Plays a role in the regulation of phosphate uptake
KM412_21425	COG0581	inorganic phosphate transmembrane transporter activity
KM412_21430	COG0573	inorganic phosphate transmembrane transporter activity
KM412_21435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM412_21440	COG0768	penicillin binding
KM412_21445	COG0477	Major facilitator Superfamily
KM412_21450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM412_21475	COG0735	belongs to the Fur family
KM412_21480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM412_21485	COG1121	(ABC) transporter
KM412_21490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_21520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM412_21525	COG2384	SAM-dependent methyltransferase
KM412_21530	COG2010	Cytochrome c
KM412_21535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM412_21540	COG0358	DNA primase activity
KM412_21550	COG0517	IMP dehydrogenase activity
KM412_21565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM412_21570	COG0295	cytidine deaminase activity
KM412_21575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM412_21585	COG1480	7TM receptor with intracellular HD hydrolase
KM412_21590	COG1702	phosphate starvation-inducible protein PhoH
KM412_21605	COG1610	YqeY-like protein
KM412_21610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM412_21615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM412_21620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM412_21650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM412_21655	COG1733	regulation of RNA biosynthetic process
KM412_21680	COG1466	dna polymerase III delta subunit
KM412_21690	COG2333	competence protein COMEC
KM412_21690	COG0658	competence protein
KM412_21695	COG2131	deaminase
KM412_21700	COG1596	polysaccharide export
KM412_21700	COG1555	photosystem II stabilization
KM412_21705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM412_21710	COG2226	methyltransferase
KM412_21715	COG0799	negative regulation of ribosome biogenesis
KM412_21720	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM412_21730	COG1534	Rna-binding protein
KM412_21740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM412_21745	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM412_21770	COG1595	DNA-templated transcription, initiation
KM412_21780	COG0778	Nitroreductase
KM412_21785	COG2357	RelA SpoT domain protein
KM412_21795	COG1785	Belongs to the alkaline phosphatase family
KM412_21805	COG2267	carboxylic ester hydrolase activity
KM412_21840	COG1404	Belongs to the peptidase S8 family
KM412_21845	COG3186	Phenylalanine-4-hydroxylase
KM412_21860	COG2259	Doxx family
KM412_21900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_21910	COG1012	belongs to the aldehyde dehydrogenase family
KM412_21910	COG1454	alcohol dehydrogenase
KM412_21915	COG0626	cystathionine gamma-synthase activity
KM412_21920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM412_21945	COG0768	penicillin binding
KM412_21960	COG0826	peptidase U32
KM412_21965	COG0826	peptidase U32
KM412_21970	COG4122	O-methyltransferase activity
KM412_21975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM412_21995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM412_22005	COG0628	permease
KM412_22025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM412_22035	COG0482	sulfurtransferase activity
KM412_22040	COG1104	cysteine desulfurase activity
KM412_22045	COG1959	2 iron, 2 sulfur cluster binding
KM412_22050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM412_22060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM412_22085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM412_22095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM412_22095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM412_22100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM412_22105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM412_22105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM412_22115	COG2244	polysaccharide biosynthetic process
KM412_22120	COG2323	membrane
KM412_22130	COG1862	Preprotein translocase
KM412_22160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM412_22170	COG0697	spore germination
KM412_22180	COG0640	Transcriptional regulator
KM412_22205	COG0157	Belongs to the NadC ModD family
KM412_22210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM412_22215	COG1104	cysteine desulfurase activity
KM412_22220	COG1827	regulation of RNA biosynthetic process
KM412_22225	COG2258	MOSC domain
KM412_22230	COG0077	Prephenate dehydratase
KM412_22235	COG0577	efflux transmembrane transporter activity
KM412_22240	COG0577	efflux transmembrane transporter activity
KM412_22245	COG1136	(ABC) transporter
KM412_22255	COG0745	RESPONSE REGULATOR receiver
KM412_22260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM412_22265	COG3290	protein histidine kinase activity
KM412_22275	COG2868	ribosomal protein
KM412_22285	COG1530	ribonuclease E activity
KM412_22290	COG1994	Peptidase M50
KM412_22295	COG0739	heme binding
KM412_22300	COG2894	cell division
KM412_22320	COG1077	Cell shape determining protein MreB Mrl
KM412_22340	COG0285	dihydrofolate synthase activity
KM412_22345	COG0525	valine-tRNA ligase activity
KM412_22355	COG1388	LysM domain
KM412_22365	COG0113	porphobilinogen synthase activity
KM412_22370	COG1587	Uroporphyrinogen-III synthase
KM412_22380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM412_22390	COG1846	Transcriptional regulator
KM412_22395	COG1764	response to oxidative stress
KM412_22410	COG1067	ATP-dependent peptidase activity
KM412_22410	COG0470	DNA polymerase III
KM412_22455	COG0622	Phosphoesterase
KM412_22470	COG5401	PFAM Sporulation and spore germination
KM412_22490	COG1309	transcriptional regulator
KM412_22505	COG2197	response regulator
KM412_22510	COG2233	PERMEase
KM412_22520	COG0402	S-adenosylhomocysteine deaminase activity
KM412_22525	COG0402	S-adenosylhomocysteine deaminase activity
KM412_22535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM412_22545	COG0444	Belongs to the ABC transporter superfamily
KM412_22550	COG4608	Belongs to the ABC transporter superfamily
KM412_22555	COG3275	phosphorelay sensor kinase activity
KM412_22560	COG3279	Response regulator of the LytR AlgR family
KM412_22575	COG1983	PspC domain protein
KM412_22580	COG1396	sequence-specific DNA binding
KM412_22585	COG0697	spore germination
KM412_22595	COG1959	2 iron, 2 sulfur cluster binding
KM412_22600	COG1668	transmembrane transport
KM412_22605	COG4152	abc transporter atp-binding protein
KM412_22610	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM412_22620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM412_22625	COG1876	peptidase activity
KM412_22630	COG0824	Thioesterase
KM412_22635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM412_22640	COG1053	succinate dehydrogenase
KM412_22645	COG2009	succinate dehydrogenase
KM412_22650	COG1719	4-vinyl reductase, 4VR
KM412_22660	COG3118	belongs to the thioredoxin family
KM412_22665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM412_22670	COG2086	electron transfer activity
KM412_22675	COG1024	Enoyl-CoA hydratase
KM412_22680	COG1309	transcriptional regulator
KM412_22685	COG0318	PFAM AMP-dependent synthetase and ligase
KM412_22705	COG2318	DinB family
KM412_22735	COG1131	(ABC) transporter
KM412_22740	COG2205	protein histidine kinase activity
KM412_22745	COG0745	RESPONSE REGULATOR receiver
KM412_22755	COG4895	conserved protein (DUF2196)
KM412_22760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM412_22775	COG4509	Sortase family
KM412_22780	COG1120	ATPase activity
KM412_22795	COG5386	Cell surface protein
KM412_22805	COG5386	Cell surface protein
KM412_22810	COG1114	Component of the transport system for branched-chain amino acids
KM412_22815	COG1187	pseudouridine synthase activity
KM412_22825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM412_22825	COG1796	DNA polymerase
KM412_22830	COG1286	toxin biosynthetic process
KM412_22875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM412_22885	COG1418	mRNA catabolic process
KM412_22910	COG2814	Major facilitator Superfamily
KM412_22915	COG1566	PFAM secretion protein HlyD family protein
KM412_22920	COG1309	transcriptional regulator
KM412_22925	COG1363	Peptidase, m42
KM412_22950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM412_22960	COG1484	DNA-dependent DNA replication
KM412_22965	COG3611	Membrane attachment protein
KM412_22975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM412_22980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM412_22985	COG0237	dephospho-CoA kinase activity
KM412_22990	COG1971	Probably functions as a manganese efflux pump
KM412_23000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM412_23000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM412_23005	COG5002	protein histidine kinase activity
KM412_23010	COG0745	RESPONSE REGULATOR receiver
KM412_23030	COG0538	isocitrate dehydrogenase activity
KM412_23035	COG0372	Belongs to the citrate synthase family
KM412_23045	COG0628	permease
KM412_23050	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM412_23075	COG1725	Transcriptional regulator
KM412_23080	COG0281	malic enzyme
KM412_23085	COG0587	DNA-directed DNA polymerase activity
KM412_23100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM412_23120	COG4109	DRTGG domain
KM412_23135	COG0006	proline dipeptidase activity
KM412_23170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_23175	COG0662	Cupin 2, conserved barrel domain protein
KM412_23185	COG1476	TRANSCRIPTIONal
KM412_23200	COG1028	Short-chain dehydrogenase reductase Sdr
KM412_23205	COG0589	response to stress
KM412_23245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_23265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM412_23270	COG0827	DNA restriction-modification system
KM412_23275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM412_23280	COG3874	Sporulation protein YtfJ
KM412_23295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM412_23305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM412_23320	COG1104	cysteine desulfurase activity
KM412_23330	COG0583	DNA-binding transcription factor activity
KM412_23335	COG0697	spore germination
KM412_23345	COG1956	GAF domain-containing protein
KM412_23350	COG0626	cystathionine gamma-synthase activity
KM412_23380	COG1595	DNA-templated transcription, initiation
KM412_23390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM412_23395	COG0454	-acetyltransferase
KM412_23400	COG0517	IMP dehydrogenase activity
KM412_23405	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM412_23415	COG0745	RESPONSE REGULATOR receiver
KM412_23425	COG0666	response to abiotic stimulus
KM412_23460	COG1609	Transcriptional regulator
KM412_23465	COG4851	CamS sex pheromone cAM373 precursor
KM412_23470	COG3118	belongs to the thioredoxin family
KM412_23480	COG2309	aminopeptidase activity
KM412_23500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_23515	COG1674	ftsk spoiiie
KM412_23525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM412_23530	COG4848	Belongs to the UPF0354 family
KM412_23535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM412_23540	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM412_23545	COG1363	Peptidase, m42
KM412_23555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_23570	COG0510	thiamine kinase activity
KM412_23575	COG1523	belongs to the glycosyl hydrolase 13 family
KM412_23590	COG1349	DNA-binding transcription factor activity
KM412_23595	COG1187	pseudouridine synthase activity
KM412_23600	COG2244	polysaccharide biosynthetic process
KM412_23605	COG2081	HI0933 family
KM412_23610	COG2814	Major facilitator Superfamily
KM412_23620	COG3832	glyoxalase III activity
KM412_23640	COG1329	Transcriptional regulator
KM412_23650	COG4975	Glucose uptake
KM412_23665	COG0314	molybdopterin synthase activity
KM412_23670	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM412_23675	COG0303	'Molybdopterin
KM412_23685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM412_23710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM412_23720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM412_23760	COG2814	Major facilitator Superfamily
KM412_23765	COG0475	glutathione-regulated potassium exporter activity
KM412_23770	COG0490	domain, Protein
KM412_23775	COG0582	viral genome integration into host DNA
KM412_23785	COG1136	(ABC) transporter
KM412_23805	COG1242	4 iron, 4 sulfur cluster binding
KM412_23810	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM412_23815	COG1131	(ABC) transporter
KM412_23825	COG1794	racemase activity, acting on amino acids and derivatives
KM412_23845	COG2267	carboxylic ester hydrolase activity
KM412_23850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM412_23855	COG0671	phosphoesterase, PA-phosphatase related
KM412_23860	COG0438	transferase activity, transferring glycosyl groups
KM412_23870	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM412_23925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM412_23930	COG5002	protein histidine kinase activity
KM412_23935	COG4191	Histidine kinase
KM412_23940	COG2267	carboxylic ester hydrolase activity
KM412_23960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM412_23965	COG1116	anion transmembrane transporter activity
KM412_23970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM412_23995	COG0494	nUDIX hydrolase
KM412_24025	COG0288	reversible hydration of carbon dioxide
KM412_24030	COG1271	oxidase subunit
KM412_24035	COG1294	oxidase, subunit
KM412_24055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_24080	COG1842	Phage shock protein A
KM412_24110	COG5002	protein histidine kinase activity
KM412_24115	COG0745	RESPONSE REGULATOR receiver
KM412_24145	COG1597	lipid kinase activity
KM412_24180	COG0586	Pfam SNARE associated Golgi protein
KM412_24190	COG0577	efflux transmembrane transporter activity
KM412_24195	COG1136	(ABC) transporter
KM412_24200	COG3708	Transcriptional regulator
KM412_24200	COG2207	Transcriptional regulator
KM412_24205	COG0745	RESPONSE REGULATOR receiver
KM412_24210	COG2205	protein histidine kinase activity
KM412_24215	COG0577	efflux transmembrane transporter activity
KM412_24225	COG0577	efflux transmembrane transporter activity
KM412_24230	COG1136	(ABC) transporter
KM412_24250	COG2188	Transcriptional regulator
KM412_24270	COG3964	amidohydrolase
KM412_24300	COG4948	Mandelate Racemase Muconate Lactonizing
KM412_24310	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM412_24315	COG0596	Alpha beta hydrolase
KM412_24320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM412_24325	COG1169	isochorismate synthase
KM412_24330	COG1575	Belongs to the MenA family. Type 1 subfamily
KM412_24335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM412_24355	COG0058	SHG alpha-glucan phosphorylase activity
KM412_24360	COG0297	glycogen (starch) synthase activity
KM412_24365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM412_24485	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM412_24520	COG1285	pathogenesis
KM412_24525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM412_24535	COG0166	Belongs to the GPI family
KM412_24540	COG2155	Conserved Protein
KM412_24545	COG1098	S1 RNA binding domain
KM412_24550	COG0436	Aminotransferase
KM412_24555	COG1522	sequence-specific DNA binding
KM412_24560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM412_24565	COG2267	carboxylic ester hydrolase activity
KM412_24575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM412_24595	COG5018	Exonuclease
KM412_24600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM412_24620	COG2050	protein possibly involved in aromatic compounds catabolism
KM412_24630	COG1268	BioY protein
KM412_24640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM412_24645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM412_24660	COG3584	3D domain protein
KM412_24675	COG1252	NADH dehydrogenase
KM412_24690	COG3708	Transcriptional regulator
KM412_24705	COG1683	Conserved Protein
KM412_24725	COG0316	Belongs to the HesB IscA family
KM412_24740	COG1252	NADH dehydrogenase
KM412_24755	COG0390	transport system, permease component
KM412_24760	COG2824	Alkylphosphonate utilization operon protein PhnA
KM412_24800	COG4837	Protein of unknown function (DUF1462)
KM412_24805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM412_24815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM412_24820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM412_24830	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM412_24835	COG0647	UMP catabolic process
KM412_24845	COG2445	Protein of unknown function DUF86
KM412_24850	COG1494	fructose-1,6-bisphosphatase
KM412_24865	COG4470	Protein conserved in bacteria
KM412_24875	COG0789	Transcriptional regulator
KM412_24880	COG4377	Putative membrane peptidase family (DUF2324)
KM412_24905	COG0739	heme binding
KM412_24915	COG3377	Domain of unknown function (DUF1805)
KM412_24920	COG0737	Belongs to the 5'-nucleotidase family
KM412_24925	COG1695	Transcriptional regulator
KM412_24935	COG0719	Fe-S assembly protein
KM412_24940	COG0822	iron-sulfur transferase activity
KM412_24945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM412_24950	COG0719	Fe-S assembly protein
KM412_24955	COG0396	ATPase activity
KM412_24960	COG1464	Belongs to the NlpA lipoprotein family
KM412_24965	COG1464	Belongs to the NlpA lipoprotein family
KM412_24970	COG2011	ABC-type metal ion transport system permease component
KM412_24975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM412_24985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM412_24990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM412_25000	COG1393	Belongs to the ArsC family
KM412_25045	COG0039	L-malate dehydrogenase activity
KM412_25065	COG1309	transcriptional regulator
KM412_25070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM412_25075	COG1960	acyl-CoA dehydrogenase activity
KM412_25080	COG0183	Belongs to the thiolase family
KM412_25085	COG1024	Enoyl-CoA hydratase
KM412_25085	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM412_25095	COG1686	Belongs to the peptidase S11 family
KM412_25110	COG0011	TIGRFAM Protein of
KM412_25115	COG0840	transmembrane signaling receptor activity
KM412_25135	COG2814	Major facilitator Superfamily
KM412_25140	COG0531	amino acid
KM412_25150	COG0706	membrane insertase activity
KM412_25160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM412_25195	COG0586	Pfam SNARE associated Golgi protein
KM412_25205	COG1376	ErfK ybiS ycfS ynhG family protein
KM412_25210	COG0745	RESPONSE REGULATOR receiver
KM412_25215	COG5002	protein histidine kinase activity
KM412_25240	COG2151	metal-sulfur cluster biosynthetic enzyme
KM412_25245	COG3227	Zinc metalloprotease (Elastase)
KM412_25250	COG1741	Belongs to the pirin family
KM412_25265	COG0475	glutathione-regulated potassium exporter activity
KM412_25270	COG0490	domain, Protein
KM412_25275	COG1115	amino acid carrier protein
KM412_25280	COG0783	Belongs to the Dps family
KM412_25295	COG1611	Belongs to the LOG family
KM412_25315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_25320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_25325	COG1115	amino acid carrier protein
KM412_25330	COG1115	amino acid carrier protein
KM412_25335	COG2910	NAD(P)H-binding
KM412_25350	COG0656	L-ascorbic acid biosynthetic process
KM412_25355	COG2814	Major facilitator Superfamily
KM412_25360	COG1733	regulation of RNA biosynthetic process
KM412_25370	COG1252	NADH dehydrogenase
KM412_25375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM412_25380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM412_25390	COG3290	protein histidine kinase activity
KM412_25390	COG0840	transmembrane signaling receptor activity
KM412_25400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM412_25405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM412_25420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM412_25475	COG0557	exoribonuclease II activity
KM412_25480	COG1647	Serine aminopeptidase, S33
KM412_25485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM412_25490	COG1346	cytolysis
KM412_25590	COG4695	Portal protein
KM412_25615	COG4974	Belongs to the 'phage' integrase family
KM412_25625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KM412_25630	COG0149	triose-phosphate isomerase activity
KM412_25640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM412_25655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM412_25680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM412_25695	COG2323	membrane
KM412_25700	COG0740	serine-type endopeptidase activity
KM412_25705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM412_25715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM412_25725	COG1051	belongs to the nudix hydrolase family
KM412_25735	COG0492	ferredoxin-NADP+ reductase activity
KM412_25740	COG0457	Tetratricopeptide repeat
KM412_25745	COG0110	maltose O-acetyltransferase activity
KM412_25765	COG1950	PFAM Membrane protein of
KM412_25775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM412_25780	COG0556	nucleotide-excision repair
KM412_25800	COG0789	Transcriptional regulator
KM412_25825	COG2855	membrane
KM412_25830	COG0583	DNA-binding transcription factor activity
KM412_25840	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM412_25845	COG0488	(ABC) transporter
KM412_25855	COG1132	(ABC) transporter
KM412_25860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM412_25865	COG3409	Peptidoglycan-binding domain 1 protein
KM412_25865	COG0793	Belongs to the peptidase S41A family
KM412_25870	COG2177	Part of the ABC transporter FtsEX involved in
KM412_25875	COG2884	Cell division ATP-binding protein ftsE
KM412_25890	COG0653	protein targeting
KM412_25895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM412_25900	COG1278	Cold shock
KM412_25905	COG1040	competence protein
KM412_25910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM412_25915	COG1388	LysM domain
KM412_25915	COG0791	NLP P60 protein
KM412_25920	COG1733	regulation of RNA biosynthetic process
KM412_25925	COG1307	EDD domain protein, DegV family
KM412_25930	COG1739	Uncharacterized protein family UPF0029
KM412_25935	COG1316	TRANSCRIPTIONal
KM412_25940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM412_25945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM412_25950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM412_25960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM412_25960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM412_25975	COG3394	polysaccharide catabolic process
KM412_25980	COG1486	melibiose metabolic process
KM412_25985	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM412_25990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM412_26000	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM412_26005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM412_26010	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM412_26020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM412_26025	COG1301	dicarboxylic acid transport
KM412_26035	COG0346	lactoylglutathione lyase activity
KM412_26040	COG1511	domain protein
KM412_26045	COG0583	DNA-binding transcription factor activity
KM412_26050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM412_26065	COG1271	oxidase subunit
KM412_26070	COG1294	oxidase, subunit
KM412_26075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM412_26095	COG2389	metal-binding protein
KM412_26105	COG1368	sulfuric ester hydrolase activity
KM412_26120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM412_26130	COG1215	transferase activity, transferring glycosyl groups
KM412_26135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM412_26140	COG3584	3D domain protein
KM412_26140	COG1388	LysM domain
KM412_26165	COG4715	Zinc finger, swim domain protein
KM412_26170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM412_26210	COG0577	efflux transmembrane transporter activity
KM412_26215	COG1136	(ABC) transporter
KM412_26250	COG5002	protein histidine kinase activity
KM412_26255	COG0745	RESPONSE REGULATOR receiver
KM412_26260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM412_26275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM412_26280	COG1134	teichoic acid transport
KM412_26285	COG1682	transport, permease protein
KM412_26290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM412_26335	COG1609	Transcriptional regulator
KM412_26350	COG0739	heme binding
KM412_26370	COG2385	sporulation resulting in formation of a cellular spore
KM412_26385	COG4836	Membrane
KM412_26390	COG1007	ATP synthesis coupled electron transport
KM412_26395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM412_26400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM412_26410	COG0839	Belongs to the complex I subunit 6 family
KM412_26425	COG0649	NAD binding
KM412_26430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM412_26445	COG5001	Diguanylate cyclase
KM412_26445	COG3300	MHYT domain
KM412_26495	COG0356	it plays a direct role in the translocation of protons across the membrane
KM412_26530	COG0698	ribose 5-phosphate isomerase
KM412_26540	COG2190	(PTS) system
KM412_26545	COG2259	Doxx family
KM412_26550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM412_26565	COG0009	L-threonylcarbamoyladenylate synthase
KM412_26580	COG2890	protein-(glutamine-N5) methyltransferase activity
KM412_26600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM412_26605	COG1494	fructose-1,6-bisphosphatase
KM412_26625	COG4821	SIS domain
KM412_26635	COG3343	RNA polymerase activity
KM412_26645	COG1960	acyl-CoA dehydrogenase activity
KM412_26650	COG1960	acyl-CoA dehydrogenase activity
KM412_26655	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM412_26660	COG0183	Belongs to the thiolase family
KM412_26665	COG2181	nitrate reductase activity
KM412_26665	COG0247	lactate metabolic process
KM412_26670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM412_26680	COG5001	Diguanylate cyclase
KM412_26680	COG3300	MHYT domain
KM412_26700	COG2197	response regulator
KM412_26705	COG4585	Histidine kinase
KM412_26710	COG0842	Transport permease protein
KM412_26715	COG1131	(ABC) transporter
KM412_26720	COG0024	Methionine aminopeptidase
KM412_26730	COG2234	aminopeptidase activity
KM412_26750	COG1595	DNA-templated transcription, initiation
KM412_26755	COG0018	arginyl-trna synthetase
KM412_26760	COG4506	Protein conserved in bacteria
KM412_26765	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM412_26780	COG0010	Belongs to the arginase family
KM412_26790	COG2814	Major facilitator Superfamily
KM412_26795	COG0789	Transcriptional regulator
KM412_26800	COG0584	glycerophosphoryl diester phosphodiesterase
KM412_26805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM412_26815	COG1994	Peptidase M50
KM412_26825	COG1078	dGTPase activity
KM412_26830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM412_26835	COG1120	ATPase activity
KM412_26840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM412_26865	COG0095	Lipoate-protein ligase
KM412_26870	COG0280	phosphate acetyltransferase
KM412_26885	COG3773	Cell wall hydrolase
KM412_26895	COG2363	Small membrane protein
KM412_26905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM412_26910	COG2233	PERMEase
KM412_26915	COG0561	phosphatase activity
KM412_26920	COG2814	Major facilitator Superfamily
KM412_26930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM412_26935	COG1131	(ABC) transporter
KM412_26940	COG2755	lipolytic protein G-D-S-L family
KM412_26945	COG1609	Transcriptional regulator
KM412_26955	COG0460	homoserine dehydrogenase
KM412_26965	COG2873	o-acetylhomoserine
KM412_26975	COG1011	Hydrolase
KM412_26980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM412_26990	COG2197	response regulator
KM412_27000	COG0351	phosphomethylpyrimidine kinase
KM412_27005	COG3706	GGDEF domain
KM412_27010	COG2879	small protein
KM412_27015	COG1966	Carbon starvation protein
KM412_27020	COG3279	Response regulator of the LytR AlgR family
KM412_27025	COG0477	Major facilitator Superfamily
KM412_27050	COG0840	transmembrane signaling receptor activity
KM412_27060	COG1607	acyl-coa hydrolase
KM412_27075	COG0488	(ABC) transporter
KM412_27095	COG0463	Glycosyl transferase, family 2
KM412_27100	COG1309	transcriptional regulator
KM412_27105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM412_27110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM412_27110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM412_27115	COG0628	permease
KM412_27130	COG3279	Response regulator of the LytR AlgR family
KM412_27135	COG3275	phosphorelay sensor kinase activity
KM412_27140	COG2814	Major facilitator Superfamily
KM412_27145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM412_27150	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM412_27155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM412_27175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM412_27180	COG1272	protein, Hemolysin III
KM412_27200	COG0516	GMP reductase activity
KM412_27205	COG1164	Oligoendopeptidase f
KM412_27225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM412_27230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM412_27235	COG4853	Protein conserved in bacteria
KM412_27240	COG4863	YycH protein
KM412_27245	COG5002	protein histidine kinase activity
KM412_27250	COG0745	RESPONSE REGULATOR receiver
KM412_27280	COG0305	Participates in initiation and elongation during chromosome replication
KM412_27290	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM412_27295	COG4241	membrane
KM412_27305	COG0629	single-stranded DNA binding
KM412_27315	COG0012	GTP binding
KM412_27320	COG4481	Protein conserved in bacteria
KM412_27325	COG0668	transmembrane transport
KM412_27335	COG1475	DNA binding
KM412_27340	COG1192	Involved in chromosome partitioning
KM412_27365	COG1847	R3H domain protein
KM412_27370	COG0706	membrane insertase activity
KM412_27380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM412_27430	COG3344	reverse transcriptase
KM412_27510	COG3344	reverse transcriptase
KM412_27700	COG4962	Type ii secretion system protein e
KM412_27835	COG2311	Membrane
KM412_27855	COG4196	transglutaminase domain protein
KM412_27860	COG0671	phosphoesterase, PA-phosphatase related
KM412_27875	COG1215	transferase activity, transferring glycosyl groups
KM412_27880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM412_27885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM412_28045	COG2002	toxin-antitoxin pair type II binding
KM412_28055	COG4974	Belongs to the 'phage' integrase family
KM412_28110	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM412_28120	COG4974	Belongs to the 'phage' integrase family
KM412_28145	COG0457	Tetratricopeptide repeat
KM412_28350	COG0791	NLP P60 protein
KM412_28350	COG0741	lytic transglycosylase activity
KM412_28415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM412_28475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM412_28485	COG4166	transmembrane transport
KM412_28525	COG1280	lysine exporter protein (LysE YggA)
KM412_28550	COG0681	Belongs to the peptidase S26 family
KM412_28625	COG1309	transcriptional regulator
KM412_28630	COG1683	Conserved Protein
KM412_28670	COG1192	Involved in chromosome partitioning