locus-tag	class	description
KM389_00010	COG0592	DNA-directed DNA polymerase activity
KM389_00015	COG2501	S4 domain
KM389_00025	COG0187	DNA topoisomerase II activity
KM389_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM389_00065	COG0516	GMP reductase activity
KM389_00065	COG0517	IMP dehydrogenase activity
KM389_00070	COG1686	Belongs to the peptidase S11 family
KM389_00100	COG1428	Deoxynucleoside kinase
KM389_00105	COG1428	Deoxynucleoside kinase
KM389_00110	COG1335	isochorismatase
KM389_00115	COG0590	tRNA wobble adenosine to inosine editing
KM389_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KM389_00180	COG1982	Orn Lys Arg decarboxylase major
KM389_00190	COG0470	DNA polymerase III
KM389_00195	COG1774	PSP1 C-terminal conserved region
KM389_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KM389_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KM389_00220	COG2002	toxin-antitoxin pair type II binding
KM389_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM389_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM389_00230	COG0084	hydrolase, TatD family'
KM389_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM389_00250	COG4466	Protein conserved in bacteria
KM389_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KM389_00270	COG0251	oxidation-reduction process
KM389_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KM389_00305	COG2002	toxin-antitoxin pair type II binding
KM389_00310	COG2244	polysaccharide biosynthetic process
KM389_00315	COG3956	TIGRFAM MazG family protein
KM389_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KM389_00340	COG1098	S1 RNA binding domain
KM389_00355	COG2208	phosphoserine phosphatase activity
KM389_00360	COG0037	tRNA processing
KM389_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KM389_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KM389_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM389_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KM389_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
KM389_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM389_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KM389_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KM389_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KM389_00420	COG1396	sequence-specific DNA binding
KM389_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM389_00455	COG3880	PFAM UvrB UvrC protein
KM389_00465	COG0542	response to heat
KM389_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KM389_00480	COG4956	integral membrane protein (PIN domain superfamily)
KM389_00500	COG1045	serine acetyltransferase
KM389_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM389_00520	COG3688	RNA-binding protein containing a PIN domain
KM389_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM389_00540	COG0250	Participates in transcription elongation, termination and antitermination
KM389_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KM389_00565	COG2813	Specifically methylates the guanine in position
KM389_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KM389_00580	COG1358	cellular component organization or biogenesis
KM389_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
KM389_00710	COG0201	protein transport
KM389_00720	COG0024	Methionine aminopeptidase
KM389_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KM389_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM389_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM389_00795	COG0489	protein tyrosine kinase activity
KM389_00805	COG2194	sulfuric ester hydrolase activity
KM389_00810	COG0726	polysaccharide deacetylase
KM389_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KM389_00895	COG4856	YbbR-like protein
KM389_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KM389_00915	COG0596	Alpha beta hydrolase
KM389_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KM389_00940	COG1506	peptidase
KM389_00940	COG4946	Tricorn protease homolog
KM389_00940	COG0823	Involved in the tonB-independent uptake of proteins
KM389_00975	COG2011	ABC-type metal ion transport system permease component
KM389_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM389_00985	COG1464	Belongs to the NlpA lipoprotein family
KM389_00990	COG0604	alcohol dehydrogenase
KM389_01000	COG0277	FAD linked oxidase domain protein
KM389_01005	COG2271	Major facilitator Superfamily
KM389_01015	COG2814	Major facilitator Superfamily
KM389_01030	COG0601	transmembrane transport
KM389_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM389_01040	COG0444	Belongs to the ABC transporter superfamily
KM389_01045	COG4608	Belongs to the ABC transporter superfamily
KM389_01050	COG4166	transmembrane transport
KM389_01060	COG2207	Transcriptional regulator
KM389_01075	COG4166	transmembrane transport
KM389_01080	COG4166	transmembrane transport
KM389_01085	COG0656	L-ascorbic acid biosynthetic process
KM389_01090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM389_01105	COG4149	molybdate abc transporter
KM389_01115	COG1910	domain protein
KM389_01125	COG0583	DNA-binding transcription factor activity
KM389_01130	COG0697	spore germination
KM389_01145	COG0204	Acyl-transferase
KM389_01155	COG1609	Transcriptional regulator
KM389_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_01175	COG0084	hydrolase, TatD family'
KM389_01180	COG5298	Protein conserved in bacteria
KM389_01205	COG0488	(ABC) transporter
KM389_01220	COG0747	negative chemotaxis
KM389_01225	COG0601	transmembrane transport
KM389_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM389_01235	COG0444	Belongs to the ABC transporter superfamily
KM389_01240	COG4608	Belongs to the ABC transporter superfamily
KM389_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
KM389_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM389_01290	COG2814	Major facilitator Superfamily
KM389_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KM389_01310	COG4294	response to UV
KM389_01315	COG0457	Tetratricopeptide repeat
KM389_01315	COG0705	Rhomboid family
KM389_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KM389_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM389_01335	COG0864	Transcriptional regulator
KM389_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
KM389_01345	COG2183	response to ionizing radiation
KM389_01440	COG0802	atpase or kinase
KM389_01445	COG1214	PFAM Peptidase M22, glycoprotease
KM389_01450	COG0456	acetyltransferase
KM389_01460	COG0488	(ABC) transporter
KM389_01475	COG1266	CAAX protease self-immunity
KM389_01495	COG2252	PERMEase
KM389_01505	COG5002	protein histidine kinase activity
KM389_01525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KM389_01530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KM389_01535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KM389_01545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KM389_01560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KM389_01570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KM389_01580	COG0151	Belongs to the GarS family
KM389_01605	COG0210	DNA helicase
KM389_01615	COG4851	CamS sex pheromone cAM373 precursor
KM389_01635	COG1335	isochorismatase
KM389_01640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM389_01645	COG2011	ABC-type metal ion transport system permease component
KM389_01650	COG1464	Belongs to the NlpA lipoprotein family
KM389_01670	COG1846	Transcriptional regulator
KM389_01695	COG1597	lipid kinase activity
KM389_01700	COG0546	phosphoglycolate phosphatase activity
KM389_01705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM389_01715	COG1012	belongs to the aldehyde dehydrogenase family
KM389_01720	COG2076	Multidrug Resistance protein
KM389_01725	COG2309	aminopeptidase activity
KM389_01740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_01745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM389_01750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KM389_01760	COG4807	Protein conserved in bacteria
KM389_01785	COG1757	Na H antiporter
KM389_01790	COG1473	amidohydrolase
KM389_01805	COG0450	alkyl hydroperoxide reductase
KM389_01825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_01830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_01835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_01850	COG0166	Belongs to the GPI family
KM389_01885	COG5002	protein histidine kinase activity
KM389_01905	COG3541	Predicted nucleotidyltransferase
KM389_01910	COG2814	Major facilitator Superfamily
KM389_01915	COG0723	plastoquinol--plastocyanin reductase activity
KM389_01915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM389_01925	COG0765	amino acid transport
KM389_01930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM389_01940	COG0840	transmembrane signaling receptor activity
KM389_01945	COG0840	transmembrane signaling receptor activity
KM389_01950	COG0366	Alpha amylase catalytic
KM389_01955	COG1263	PTS System
KM389_01955	COG2190	(PTS) system
KM389_01955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_01985	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KM389_02000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM389_02010	COG1116	anion transmembrane transporter activity
KM389_02015	COG0488	(ABC) transporter
KM389_02060	COG2270	Major facilitator Superfamily
KM389_02075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM389_02090	COG2310	stress, protein
KM389_02095	COG2310	stress, protein
KM389_02100	COG2310	stress, protein
KM389_02105	COG0861	Integral membrane protein TerC family
KM389_02115	COG3853	Toxic anion resistance protein (TelA)
KM389_02130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KM389_02140	COG1295	ribonuclease BN
KM389_02145	COG2217	Heavy metal translocating P-type atpase
KM389_02150	COG0697	spore germination
KM389_02170	COG0586	Pfam SNARE associated Golgi protein
KM389_02185	COG3871	stress protein (general stress protein 26)
KM389_02190	COG0387	Pfam Sodium calcium exchanger
KM389_02200	COG0535	radical SAM domain protein
KM389_02225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM389_02230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KM389_02235	COG0582	viral genome integration into host DNA
KM389_02245	COG1396	sequence-specific DNA binding
KM389_02260	COG1396	sequence-specific DNA binding
KM389_02295	COG1484	DNA-dependent DNA replication
KM389_02525	COG0101	tRNA pseudouridine synthase activity
KM389_02535	COG3829	transcription factor binding
KM389_02545	COG0833	amino acid
KM389_02550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM389_02580	COG1263	PTS System
KM389_02580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_02585	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM389_02600	COG0463	Glycosyl transferase, family 2
KM389_02615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KM389_02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM389_02635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KM389_02655	COG1228	amidohydrolase
KM389_02660	COG1090	epimerase
KM389_02690	COG1988	membrane-bound metal-dependent
KM389_02695	COG1194	a g-specific adenine glycosylase
KM389_02720	COG1132	(ABC) transporter
KM389_02725	COG4129	membrane
KM389_02730	COG0067	glutamate synthase
KM389_02730	COG0069	glutamate synthase activity
KM389_02730	COG0070	glutamate synthase
KM389_02740	COG4555	ABC transporter
KM389_02760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KM389_02765	COG0735	belongs to the Fur family
KM389_02880	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KM389_02885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KM389_02895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KM389_02905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KM389_02915	COG2766	serine protein kinase
KM389_02935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM389_02945	COG1585	Membrane protein implicated in regulation of membrane protease activity
KM389_02950	COG2268	Band 7 protein
KM389_02960	COG3290	protein histidine kinase activity
KM389_02965	COG4565	transcriptional regulatory protein
KM389_02970	COG2851	Citrate transporter
KM389_02990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM389_02995	COG3842	ATPase activity
KM389_03000	COG1175	transmembrane transport
KM389_03005	COG0395	ABC-type sugar transport system, permease component
KM389_03015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KM389_03020	COG0745	RESPONSE REGULATOR receiver
KM389_03025	COG5002	protein histidine kinase activity
KM389_03035	COG4990	cell redox homeostasis
KM389_03045	COG3290	protein histidine kinase activity
KM389_03050	COG4565	transcriptional regulatory protein
KM389_03055	COG3493	citrate carrier protein
KM389_03060	COG0281	malic enzyme
KM389_03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_03085	COG5002	protein histidine kinase activity
KM389_03090	COG0745	RESPONSE REGULATOR receiver
KM389_03095	COG0456	acetyltransferase
KM389_03095	COG0454	-acetyltransferase
KM389_03100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM389_03105	COG3383	formate dehydrogenase (NAD+) activity
KM389_03110	COG2427	Protein of unknown function (DUF1641)
KM389_03125	COG0531	amino acid
KM389_03130	COG0640	Transcriptional regulator
KM389_03135	COG2217	Heavy metal translocating P-type atpase
KM389_03140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KM389_03155	COG3227	Zinc metalloprotease (Elastase)
KM389_03175	COG2720	vancomycin resistance protein
KM389_03180	COG1316	TRANSCRIPTIONal
KM389_03185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_03190	COG0346	lactoylglutathione lyase activity
KM389_03195	COG1253	flavin adenine dinucleotide binding
KM389_03200	COG1027	Aspartate ammonia-lyase
KM389_03205	COG1620	l-lactate permease
KM389_03220	COG3104	oligopeptide transport
KM389_03225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_03245	COG2226	methyltransferase
KM389_03250	COG0156	8-amino-7-oxononanoate synthase activity
KM389_03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM389_03265	COG4548	von Willebrand factor, type A
KM389_03270	COG0714	Associated with various cellular activities
KM389_03275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM389_03295	COG0531	amino acid
KM389_03300	COG2188	Transcriptional regulator
KM389_03305	COG1263	PTS System
KM389_03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_03310	COG0366	Alpha amylase catalytic
KM389_03325	COG0697	spore germination
KM389_03335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM389_03340	COG1115	amino acid carrier protein
KM389_03345	COG1126	abc transporter atp-binding protein
KM389_03350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM389_03355	COG0765	amino acid transport
KM389_03360	COG0765	amino acid transport
KM389_03365	COG0833	amino acid
KM389_03390	COG2378	regulation of single-species biofilm formation
KM389_03395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KM389_03400	COG5002	protein histidine kinase activity
KM389_03415	COG0659	secondary active sulfate transmembrane transporter activity
KM389_03430	COG0747	negative chemotaxis
KM389_03440	COG0601	transmembrane transport
KM389_03445	COG4608	Belongs to the ABC transporter superfamily
KM389_03455	COG2271	Major facilitator Superfamily
KM389_03460	COG1846	Transcriptional regulator
KM389_03470	COG1609	Transcriptional regulator
KM389_03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM389_03490	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM389_03495	COG1879	ABC-type sugar transport system periplasmic component
KM389_03520	COG1063	alcohol dehydrogenase
KM389_03535	COG3568	Endonuclease Exonuclease Phosphatase
KM389_03560	COG1968	undecaprenyl-diphosphatase activity
KM389_03565	COG0840	transmembrane signaling receptor activity
KM389_03570	COG3584	3D domain protein
KM389_03570	COG1388	LysM domain
KM389_03575	COG1476	TRANSCRIPTIONal
KM389_03590	COG3104	oligopeptide transport
KM389_03595	COG1114	Component of the transport system for branched-chain amino acids
KM389_03610	COG1113	amino acid transport
KM389_03615	COG2252	PERMEase
KM389_03640	COG0475	glutathione-regulated potassium exporter activity
KM389_03640	COG0569	domain protein
KM389_03655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KM389_03660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KM389_03665	COG0833	amino acid
KM389_03670	COG4990	cell redox homeostasis
KM389_03685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM389_03690	COG0697	spore germination
KM389_03695	COG0531	amino acid
KM389_03705	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM389_03710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM389_03715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KM389_03715	COG1918	ferrous iron import across plasma membrane
KM389_03720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM389_03725	COG0573	inorganic phosphate transmembrane transporter activity
KM389_03730	COG0581	inorganic phosphate transmembrane transporter activity
KM389_03740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM389_03860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KM389_03880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM389_03885	COG1116	anion transmembrane transporter activity
KM389_03890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM389_03895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM389_03900	COG0352	thiamine-phosphate diphosphorylase activity
KM389_03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM389_03910	COG2104	thiamine diphosphate biosynthetic process
KM389_03920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM389_03925	COG0351	phosphomethylpyrimidine kinase
KM389_03965	COG2205	protein histidine kinase activity
KM389_03970	COG2814	Major facilitator Superfamily
KM389_03975	COG1846	Transcriptional regulator
KM389_03990	COG2252	PERMEase
KM389_03995	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_04010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KM389_04015	COG1621	beta-fructofuranosidase activity
KM389_04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_04020	COG1263	PTS System
KM389_04025	COG1609	Transcriptional regulator
KM389_04035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM389_04040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KM389_04075	COG0778	Nitroreductase
KM389_04080	COG2719	SpoVR family
KM389_04105	COG0446	pyridine nucleotide-disulphide oxidoreductase
KM389_04110	COG1937	Protein conserved in bacteria
KM389_04115	COG0425	Belongs to the sulfur carrier protein TusA family
KM389_04115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_04125	COG0425	Belongs to the sulfur carrier protein TusA family
KM389_04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_04140	COG2210	Belongs to the sulfur carrier protein TusA family
KM389_04145	COG0730	response to heat
KM389_04155	COG1316	TRANSCRIPTIONal
KM389_04160	COG0604	alcohol dehydrogenase
KM389_04165	COG1283	sodium-dependent phosphate transmembrane transporter activity
KM389_04180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM389_04180	COG3711	transcriptional antiterminator
KM389_04185	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM389_04190	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM389_04210	COG3584	3D domain protein
KM389_04210	COG1388	LysM domain
KM389_04215	COG0577	efflux transmembrane transporter activity
KM389_04220	COG1136	(ABC) transporter
KM389_04230	COG5522	Integral membrane protein (intg_mem_TP0381)
KM389_04245	COG1114	Component of the transport system for branched-chain amino acids
KM389_04250	COG3546	catalase activity
KM389_04285	COG0586	Pfam SNARE associated Golgi protein
KM389_04320	COG0531	amino acid
KM389_04325	COG0475	glutathione-regulated potassium exporter activity
KM389_04335	COG1737	Transcriptional regulator
KM389_04345	COG1263	PTS System
KM389_04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_04355	COG2259	Doxx family
KM389_04370	COG0697	spore germination
KM389_04375	COG1522	sequence-specific DNA binding
KM389_04390	COG2076	Multidrug Resistance protein
KM389_04395	COG1309	transcriptional regulator
KM389_04400	COG2814	Major facilitator Superfamily
KM389_04405	COG1733	regulation of RNA biosynthetic process
KM389_04415	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM389_04420	COG4533	DNA binding
KM389_04425	COG2211	Major facilitator Superfamily
KM389_04435	COG0693	protein deglycase activity
KM389_04440	COG0753	catalase activity
KM389_04440	COG0693	protein deglycase activity
KM389_04450	COG0531	amino acid
KM389_04455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KM389_04465	COG1012	belongs to the aldehyde dehydrogenase family
KM389_04470	COG1132	(ABC) transporter
KM389_04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM389_04485	COG0765	amino acid transport
KM389_04490	COG1126	abc transporter atp-binding protein
KM389_04505	COG0189	ligase activity
KM389_04535	COG0028	Belongs to the TPP enzyme family
KM389_04540	COG3527	Alpha-acetolactate decarboxylase
KM389_04555	COG0561	phosphatase activity
KM389_04570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM389_04585	COG0659	secondary active sulfate transmembrane transporter activity
KM389_04605	COG0653	protein targeting
KM389_04610	COG2244	polysaccharide biosynthetic process
KM389_04620	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM389_04625	COG4196	transglutaminase domain protein
KM389_04640	COG1696	Membrane protein involved in D-alanine export
KM389_04655	COG1024	Enoyl-CoA hydratase
KM389_04675	COG1363	Peptidase, m42
KM389_04695	COG3938	Belongs to the proline racemase family
KM389_04735	COG0601	transmembrane transport
KM389_04740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM389_04750	COG4608	Belongs to the ABC transporter superfamily
KM389_04755	COG0322	excinuclease ABC activity
KM389_04785	COG0477	Major facilitator Superfamily
KM389_04790	COG3290	protein histidine kinase activity
KM389_04795	COG4565	transcriptional regulatory protein
KM389_04800	COG3181	Tripartite tricarboxylate transporter family receptor
KM389_04830	COG4978	Transcriptional regulator
KM389_04830	COG0789	Transcriptional regulator
KM389_04845	COG0305	Participates in initiation and elongation during chromosome replication
KM389_04885	COG0477	Major facilitator Superfamily
KM389_04930	COG3320	Male sterility
KM389_04930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM389_04935	COG1309	transcriptional regulator
KM389_04955	COG1183	phosphatidylcholine synthase activity
KM389_04975	COG2376	Dihydroxyacetone kinase
KM389_04985	COG2376	Dihydroxyacetone kinase
KM389_04990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM389_04995	COG1959	2 iron, 2 sulfur cluster binding
KM389_05025	COG2770	Histidine kinase
KM389_05025	COG3437	response regulator, receiver
KM389_05075	COG3237	CsbD-like
KM389_05100	COG1191	sigma factor activity
KM389_05110	COG2208	phosphoserine phosphatase activity
KM389_05115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM389_05120	COG0784	Response regulator, receiver
KM389_05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM389_05120	COG2198	Histidine kinase
KM389_05120	COG2205	protein histidine kinase activity
KM389_05175	COG0420	3'-5' exonuclease activity
KM389_05180	COG4717	serine-type aminopeptidase activity
KM389_05200	COG1309	transcriptional regulator
KM389_05205	COG2814	Major facilitator Superfamily
KM389_05210	COG0346	lactoylglutathione lyase activity
KM389_05220	COG0346	lactoylglutathione lyase activity
KM389_05225	COG0457	Tetratricopeptide repeat
KM389_05230	COG2267	carboxylic ester hydrolase activity
KM389_05250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KM389_05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KM389_05265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KM389_05305	COG0477	Major facilitator Superfamily
KM389_05310	COG0477	Major facilitator Superfamily
KM389_05320	COG3973	AAA domain
KM389_05325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM389_05345	COG4980	gas vesicle protein
KM389_05350	COG0537	adenosine 5'-monophosphoramidase activity
KM389_05355	COG1131	(ABC) transporter
KM389_05360	COG4473	ABC transporter
KM389_05375	COG1309	transcriptional regulator
KM389_05385	COG3402	PFAM membrane-flanked domain
KM389_05435	COG3402	PFAM membrane-flanked domain
KM389_05440	COG3428	Bacterial PH domain
KM389_05445	COG2329	Antibiotic biosynthesis monooxygenase
KM389_05450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM389_05455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KM389_05460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM389_05465	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM389_05500	COG1309	transcriptional regulator
KM389_05505	COG1511	domain protein
KM389_05530	COG1609	Transcriptional regulator
KM389_05540	COG1234	tRNA 3'-trailer cleavage
KM389_05545	COG0095	Lipoate-protein ligase
KM389_05555	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_05585	COG3209	COG3209 Rhs family protein
KM389_05625	COG1078	dGTPase activity
KM389_05635	COG1595	DNA-templated transcription, initiation
KM389_05640	COG2207	Transcriptional regulator
KM389_05640	COG3708	Transcriptional regulator
KM389_05655	COG2205	protein histidine kinase activity
KM389_05660	COG0745	RESPONSE REGULATOR receiver
KM389_05685	COG0501	Belongs to the peptidase M48B family
KM389_05690	COG0840	transmembrane signaling receptor activity
KM389_05695	COG0697	spore germination
KM389_05715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KM389_05720	COG2224	Isocitrate lyase
KM389_05745	COG4903	ComK protein
KM389_05750	COG0398	Pfam SNARE associated Golgi protein
KM389_05760	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KM389_05765	COG1074	ATP-dependent DNA helicase activity
KM389_05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
KM389_05835	COG0367	asparagine synthase
KM389_05840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KM389_05845	COG0753	catalase activity
KM389_05850	COG0004	ammonium transporteR
KM389_05870	COG2996	Protein conserved in bacteria
KM389_05880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM389_05890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_05905	COG0561	phosphatase activity
KM389_05915	COG0542	response to heat
KM389_05925	COG2267	carboxylic ester hydrolase activity
KM389_05940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_05945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KM389_05950	COG5504	Zn-dependent protease
KM389_05960	COG0180	Tryptophanyl-tRNA synthetase
KM389_05970	COG4166	transmembrane transport
KM389_05975	COG0601	transmembrane transport
KM389_05980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM389_05985	COG0444	Belongs to the ABC transporter superfamily
KM389_05990	COG4608	Belongs to the ABC transporter superfamily
KM389_05995	COG0534	Mate efflux family protein
KM389_06000	COG4166	transmembrane transport
KM389_06015	COG0861	Integral membrane protein TerC family
KM389_06020	COG4862	establishment of competence for transformation
KM389_06025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM389_06035	COG1164	Oligoendopeptidase f
KM389_06045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM389_06050	COG2346	COG2346, Truncated hemoglobins
KM389_06055	COG4116	CYTH
KM389_06065	COG2357	RelA SpoT domain protein
KM389_06075	COG0564	pseudouridine synthase activity
KM389_06095	COG0463	Glycosyl transferase, family 2
KM389_06095	COG1216	Glycosyl transferase, family 2
KM389_06115	COG0457	Tetratricopeptide repeat
KM389_06115	COG0463	Glycosyl transferase, family 2
KM389_06135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KM389_06150	COG1091	dTDP-4-dehydrorhamnose reductase activity
KM389_06195	COG2153	protein acetylation
KM389_06205	COG2382	esterase
KM389_06220	COG5492	domain, Protein
KM389_06225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM389_06235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KM389_06235	COG0512	Glutamine amidotransferase of anthranilate synthase
KM389_06270	COG1620	l-lactate permease
KM389_06275	COG5634	Uncharacterized conserved protein (DUF2278)
KM389_06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM389_06340	COG1476	TRANSCRIPTIONal
KM389_06400	COG2226	methyltransferase
KM389_06410	COG1686	Belongs to the peptidase S11 family
KM389_06415	COG0681	Belongs to the peptidase S26 family
KM389_06450	COG1012	belongs to the aldehyde dehydrogenase family
KM389_06455	COG3842	ATPase activity
KM389_06460	COG1176	ABC-type spermidine putrescine transport system, permease component I
KM389_06465	COG1177	transmembrane transport
KM389_06470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KM389_06480	COG2409	Drug exporters of the RND superfamily
KM389_06490	COG0564	pseudouridine synthase activity
KM389_06500	COG2340	Cysteine-rich secretory protein family
KM389_06505	COG0247	lactate metabolic process
KM389_06510	COG0277	FAD linked oxidase domain protein
KM389_06515	COG3835	regulator
KM389_06525	COG0745	RESPONSE REGULATOR receiver
KM389_06530	COG5002	protein histidine kinase activity
KM389_06535	COG2186	Transcriptional regulator
KM389_06555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KM389_06570	COG2116	formate transmembrane transporter activity
KM389_06575	COG0861	Integral membrane protein TerC family
KM389_06590	COG2030	dehydratase
KM389_06610	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_06615	COG3243	poly(R)-hydroxyalkanoic acid synthase
KM389_06620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM389_06625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM389_06640	COG1840	ABC-type Fe3 transport system, periplasmic component
KM389_06670	COG1349	DNA-binding transcription factor activity
KM389_06690	COG2861	carbohydrate metabolic process
KM389_06700	COG3852	Histidine kinase
KM389_06705	COG1846	Transcriptional regulator
KM389_06715	COG2318	DinB family
KM389_06720	COG5002	protein histidine kinase activity
KM389_06730	COG0720	synthase
KM389_06745	COG4873	Protein conserved in bacteria
KM389_06775	COG1780	Probably involved in ribonucleotide reductase function
KM389_06795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KM389_06800	COG1725	Transcriptional regulator
KM389_06805	COG1131	(ABC) transporter
KM389_06815	COG1131	(ABC) transporter
KM389_06820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM389_06835	COG1522	sequence-specific DNA binding
KM389_06845	COG1335	isochorismatase
KM389_06855	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM389_06860	COG2070	2-Nitropropane dioxygenase
KM389_06865	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM389_06875	COG1696	Membrane protein involved in D-alanine export
KM389_06900	COG0716	FMN binding
KM389_06915	COG3173	Aminoglycoside phosphotransferase
KM389_06935	COG0534	Mate efflux family protein
KM389_06940	COG1968	undecaprenyl-diphosphatase activity
KM389_06955	COG1846	Transcriptional regulator
KM389_06965	COG1301	dicarboxylic acid transport
KM389_06970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KM389_06975	COG4709	membrane
KM389_06980	COG3874	Sporulation protein YtfJ
KM389_07005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM389_07010	COG0028	Belongs to the TPP enzyme family
KM389_07015	COG0440	acetolactate synthase activity
KM389_07020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM389_07030	COG0473	3-isopropylmalate dehydrogenase activity
KM389_07055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KM389_07090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM389_07105	COG1183	phosphatidylcholine synthase activity
KM389_07110	COG1368	sulfuric ester hydrolase activity
KM389_07120	COG0019	diaminopimelate decarboxylase activity
KM389_07140	COG0529	Catalyzes the synthesis of activated sulfate
KM389_07145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM389_07165	COG1648	precorrin-2 dehydrogenase activity
KM389_07170	COG0733	neurotransmitter:sodium symporter activity
KM389_07190	COG1757	Na H antiporter
KM389_07205	COG4758	membrane
KM389_07210	COG4585	Histidine kinase
KM389_07215	COG2197	response regulator
KM389_07225	COG1114	Component of the transport system for branched-chain amino acids
KM389_07235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KM389_07260	COG1017	nitric oxide dioxygenase activity
KM389_07260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KM389_07275	COG0730	response to heat
KM389_07280	COG0306	phosphate transporter
KM389_07285	COG1392	Phosphate transport regulator
KM389_07290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM389_07305	COG3852	Histidine kinase
KM389_07310	COG1801	Protein of unknown function DUF72
KM389_07320	COG0582	viral genome integration into host DNA
KM389_07325	COG5002	protein histidine kinase activity
KM389_07345	COG0392	lysyltransferase activity
KM389_07345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KM389_07360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM389_07365	COG1686	Belongs to the peptidase S11 family
KM389_07370	COG2715	membrane protein required for spore maturation
KM389_07375	COG0700	Nucleoside recognition
KM389_07380	COG1187	pseudouridine synthase activity
KM389_07390	COG1333	cytochrome c biogenesis protein
KM389_07395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM389_07400	COG0745	RESPONSE REGULATOR receiver
KM389_07405	COG5002	protein histidine kinase activity
KM389_07410	COG2096	Adenosyltransferase
KM389_07425	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KM389_07430	COG1141	Ferredoxin
KM389_07435	COG4955	Helix-turn-helix domain
KM389_07440	COG0514	ATP-dependent DNA helicase (RecQ)
KM389_07445	COG1266	CAAX protease self-immunity
KM389_07465	COG4862	establishment of competence for transformation
KM389_07470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KM389_07490	COG0492	ferredoxin-NADP+ reductase activity
KM389_07565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM389_07580	COG0142	geranyltranstransferase activity
KM389_07590	COG0142	geranyltranstransferase activity
KM389_07610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM389_07615	COG0457	Tetratricopeptide repeat
KM389_07635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KM389_07645	COG4347	Protein of unknown function (DUF1405)
KM389_07660	COG2738	Putative neutral zinc metallopeptidase
KM389_07670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_07675	COG1694	Mazg nucleotide pyrophosphohydrolase
KM389_07690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM389_07695	COG0438	transferase activity, transferring glycosyl groups
KM389_07730	COG1199	ATP-dependent helicase activity
KM389_07730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KM389_07750	COG3935	DnaD domain protein
KM389_07755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KM389_07765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM389_07765	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM389_07825	COG0116	Belongs to the methyltransferase superfamily
KM389_07835	COG1199	ATP-dependent helicase activity
KM389_07840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KM389_07850	COG3173	Aminoglycoside phosphotransferase
KM389_07855	COG0024	Methionine aminopeptidase
KM389_07865	COG2233	PERMEase
KM389_07870	COG2311	Membrane
KM389_07875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM389_07885	COG0456	acetyltransferase
KM389_07935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM389_07960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KM389_07975	COG1215	transferase activity, transferring glycosyl groups
KM389_07980	COG0438	transferase activity, transferring glycosyl groups
KM389_07995	COG0454	-acetyltransferase
KM389_08015	COG0328	RNA-DNA hybrid ribonuclease activity
KM389_08055	COG1280	lysine exporter protein (LysE YggA)
KM389_08070	COG3162	membrane
KM389_08075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM389_08080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM389_08090	COG0475	glutathione-regulated potassium exporter activity
KM389_08095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM389_08100	COG0789	Transcriptional regulator
KM389_08100	COG4978	Transcriptional regulator
KM389_08110	COG2323	membrane
KM389_08115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KM389_08170	COG1923	regulation of RNA biosynthetic process
KM389_08180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM389_08185	COG1360	Flagellar Motor Protein
KM389_08190	COG2201	protein-glutamate methylesterase activity
KM389_08195	COG0643	Histidine kinase
KM389_08195	COG2198	Histidine kinase
KM389_08200	COG0643	Histidine kinase
KM389_08200	COG2198	Histidine kinase
KM389_08205	COG1776	CheC inhibitor of MCP methylation
KM389_08205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM389_08220	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KM389_08240	COG1256	bacterial-type flagellum assembly
KM389_08265	COG1815	bacterial-type flagellum-dependent cell motility
KM389_08270	COG1558	bacterial-type flagellum-dependent cell motility
KM389_08285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM389_08295	COG1157	protein secretion by the type III secretion system
KM389_08335	COG0835	chemotaxis
KM389_08335	COG0784	Response regulator, receiver
KM389_08345	COG0463	Glycosyl transferase, family 2
KM389_08380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KM389_08385	COG0741	lytic transglycosylase activity
KM389_08400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KM389_08400	COG1776	CheC inhibitor of MCP methylation
KM389_08410	COG1338	Plays a role in the flagellum-specific transport system
KM389_08415	COG1987	bacterial-type flagellum assembly
KM389_08425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM389_08430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KM389_08435	COG1419	protein localization to endoplasmic reticulum
KM389_08440	COG4786	Flagellar basal body rod
KM389_08445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM389_08470	COG1309	transcriptional regulator
KM389_08490	COG2329	Antibiotic biosynthesis monooxygenase
KM389_08515	COG0583	DNA-binding transcription factor activity
KM389_08520	COG3842	ATPase activity
KM389_08525	COG0725	ABC transporter, periplasmic molybdate-binding protein
KM389_08535	COG1234	tRNA 3'-trailer cleavage
KM389_08560	COG1686	Belongs to the peptidase S11 family
KM389_08570	COG0406	alpha-ribazole phosphatase activity
KM389_08600	COG0367	asparagine synthase
KM389_08630	COG1802	Transcriptional regulator
KM389_08635	COG0697	spore germination
KM389_08640	COG0523	cobalamin synthesis protein
KM389_08645	COG0701	Predicted permease
KM389_08655	COG1216	Glycosyl transferase, family 2
KM389_08655	COG0438	transferase activity, transferring glycosyl groups
KM389_08660	COG1757	Na H antiporter
KM389_08665	COG0114	fumarate hydratase activity
KM389_08690	COG3340	Belongs to the peptidase S51 family
KM389_08710	COG0785	Cytochrome C biogenesis protein
KM389_08740	COG2733	membrane
KM389_08775	COG1131	(ABC) transporter
KM389_08790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM389_08795	COG0528	UMP kinase activity
KM389_08805	COG1027	Aspartate ammonia-lyase
KM389_08810	COG0281	malic enzyme
KM389_08815	COG4191	Histidine kinase
KM389_08820	COG0784	Response regulator, receiver
KM389_08825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM389_08880	COG1051	belongs to the nudix hydrolase family
KM389_08885	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM389_08895	COG2814	Major facilitator Superfamily
KM389_08910	COG1966	Carbon starvation protein
KM389_08925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_08935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KM389_08945	COG2223	nitrite transmembrane transporter activity
KM389_08950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM389_08965	COG2244	polysaccharide biosynthetic process
KM389_08970	COG0733	neurotransmitter:sodium symporter activity
KM389_08980	COG5566	PFAM Mor transcription activator
KM389_08985	COG2323	membrane
KM389_09000	COG2084	Dehydrogenase
KM389_09015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM389_09025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM389_09030	COG0028	Belongs to the TPP enzyme family
KM389_09035	COG0440	acetolactate synthase activity
KM389_09040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KM389_09050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KM389_09075	COG2814	Major facilitator Superfamily
KM389_09080	COG3384	dioxygenase
KM389_09090	COG3279	Response regulator of the LytR AlgR family
KM389_09095	COG0427	acetyl-CoA hydrolase
KM389_09115	COG1073	alpha beta
KM389_09145	COG0535	radical SAM domain protein
KM389_09150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_09170	COG1914	H( )-stimulated, divalent metal cation uptake system
KM389_09185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM389_09215	COG2390	Transcriptional regulator
KM389_09225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_09230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KM389_09245	COG4224	UPF0291 protein
KM389_09265	COG0006	proline dipeptidase activity
KM389_09270	COG2132	Multicopper oxidase
KM389_09285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM389_09300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM389_09315	COG1276	copper resistance
KM389_09315	COG2372	response to copper ion
KM389_09320	COG4549	nuclear export factor GLE1
KM389_09330	COG0697	spore germination
KM389_09335	COG0583	DNA-binding transcription factor activity
KM389_09340	COG1959	2 iron, 2 sulfur cluster binding
KM389_09345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KM389_09350	COG0778	Nitroreductase
KM389_09360	COG0628	permease
KM389_09370	COG1231	oxidoreductase activity
KM389_09375	COG0523	cobalamin synthesis protein
KM389_09390	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_09395	COG2030	dehydratase
KM389_09400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_09410	COG0411	ABC transporter
KM389_09430	COG0583	DNA-binding transcription factor activity
KM389_09450	COG1846	Transcriptional regulator
KM389_09460	COG1271	oxidase subunit
KM389_09465	COG1294	oxidase, subunit
KM389_09470	COG4988	ABC transporter
KM389_09475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KM389_09495	COG1686	Belongs to the peptidase S11 family
KM389_09510	COG0791	NLP P60 protein
KM389_09510	COG1388	LysM domain
KM389_09525	COG0745	RESPONSE REGULATOR receiver
KM389_09530	COG5002	protein histidine kinase activity
KM389_09540	COG0300	oxidoreductase activity
KM389_09575	COG0460	homoserine dehydrogenase
KM389_09600	COG1316	TRANSCRIPTIONal
KM389_09610	COG0745	RESPONSE REGULATOR receiver
KM389_09615	COG5002	protein histidine kinase activity
KM389_09630	COG1285	pathogenesis
KM389_09635	COG1247	-acetyltransferase
KM389_09655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM389_09665	COG1082	Xylose isomerase domain protein TIM barrel
KM389_09680	COG1279	arginine transmembrane transporter activity
KM389_09690	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM389_09730	COG2002	toxin-antitoxin pair type II binding
KM389_09735	COG1404	Belongs to the peptidase S8 family
KM389_09740	COG0640	Transcriptional regulator
KM389_09745	COG0667	Aldo Keto reductase
KM389_09750	COG2814	Major facilitator Superfamily
KM389_09775	COG0840	transmembrane signaling receptor activity
KM389_09790	COG3949	Membrane
KM389_09795	COG0783	Belongs to the Dps family
KM389_09810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM389_09820	COG1231	oxidoreductase activity
KM389_09830	COG4989	oxidoreductase activity
KM389_09835	COG0523	cobalamin synthesis protein
KM389_09840	COG0456	acetyltransferase
KM389_09895	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM389_09895	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM389_09905	COG0702	epimerase
KM389_09915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM389_09925	COG4166	transmembrane transport
KM389_09940	COG0406	alpha-ribazole phosphatase activity
KM389_09950	COG5337	Spore coat protein CotH
KM389_09955	COG1051	belongs to the nudix hydrolase family
KM389_09960	COG0586	Pfam SNARE associated Golgi protein
KM389_09965	COG2244	polysaccharide biosynthetic process
KM389_09975	COG0701	Predicted permease
KM389_09980	COG3689	TIGRFAM TIGR03943 family protein
KM389_09985	COG1607	acyl-coa hydrolase
KM389_09995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM389_10010	COG0702	epimerase
KM389_10015	COG2839	Protein conserved in bacteria
KM389_10020	COG1253	flavin adenine dinucleotide binding
KM389_10035	COG1114	Component of the transport system for branched-chain amino acids
KM389_10040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM389_10060	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM389_10070	COG1876	peptidase activity
KM389_10080	COG0154	amidase activity
KM389_10085	COG2211	Major facilitator Superfamily
KM389_10105	COG0561	phosphatase activity
KM389_10115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KM389_10120	COG4106	trans-aconitate 2-methyltransferase activity
KM389_10135	COG1819	glycosyl
KM389_10140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_10145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_10170	COG0456	acetyltransferase
KM389_10220	COG3874	Sporulation protein YtfJ
KM389_10245	COG2226	methyltransferase
KM389_10270	COG0346	lactoylglutathione lyase activity
KM389_10280	COG0604	alcohol dehydrogenase
KM389_10285	COG1595	DNA-templated transcription, initiation
KM389_10310	COG0386	Belongs to the glutathione peroxidase family
KM389_10315	COG1305	Transglutaminase-like
KM389_10320	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KM389_10325	COG0714	Associated with various cellular activities
KM389_10340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KM389_10345	COG1140	nitrate reductase beta subunit
KM389_10350	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KM389_10355	COG2181	nitrate reductase activity
KM389_10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM389_10380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KM389_10385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM389_10390	COG0303	'Molybdopterin
KM389_10395	COG0314	molybdopterin synthase activity
KM389_10405	COG2223	nitrite transmembrane transporter activity
KM389_10420	COG1648	precorrin-2 dehydrogenase activity
KM389_10430	COG1587	Uroporphyrinogen-III synthase
KM389_10430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KM389_10435	COG2146	nitrite reductase [NAD(P)H] activity
KM389_10440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KM389_10445	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KM389_10480	COG2359	stage V sporulation protein S
KM389_10495	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM389_10510	COG1418	mRNA catabolic process
KM389_10515	COG0488	(ABC) transporter
KM389_10530	COG0629	single-stranded DNA binding
KM389_10545	COG1413	lyase activity
KM389_10560	COG2521	methyltransferase
KM389_10560	COG2136	Putative SAM-dependent methyltransferase
KM389_10565	COG0018	arginyl-trna synthetase
KM389_10590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KM389_10610	COG0017	Asparaginyl-tRNA synthetase
KM389_10700	COG1929	Belongs to the glycerate kinase type-1 family
KM389_10705	COG0471	metal ion transport
KM389_10710	COG0745	RESPONSE REGULATOR receiver
KM389_10715	COG5002	protein histidine kinase activity
KM389_10715	COG3850	Histidine kinase
KM389_10730	COG0733	neurotransmitter:sodium symporter activity
KM389_10755	COG2610	gluconate transmembrane transporter activity
KM389_10760	COG1454	alcohol dehydrogenase
KM389_10765	COG1794	racemase activity, acting on amino acids and derivatives
KM389_10775	COG0456	acetyltransferase
KM389_10790	COG1131	(ABC) transporter
KM389_10805	COG0546	phosphoglycolate phosphatase activity
KM389_10825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM389_10840	COG0768	penicillin binding
KM389_10845	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KM389_10850	COG0204	Acyl-transferase
KM389_10855	COG1272	protein, Hemolysin III
KM389_10865	COG0805	protein transport
KM389_10875	COG1307	EDD domain protein, DegV family
KM389_10880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KM389_10885	COG1999	signal sequence binding
KM389_10890	COG0071	Belongs to the small heat shock protein (HSP20) family
KM389_10895	COG0367	asparagine synthase
KM389_10910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_10915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KM389_10940	COG1051	belongs to the nudix hydrolase family
KM389_10950	COG0668	transmembrane transport
KM389_10955	COG4585	Histidine kinase
KM389_10955	COG2203	Gaf domain
KM389_10960	COG2197	response regulator
KM389_10970	COG1064	alcohol dehydrogenase
KM389_10995	COG1070	Carbohydrate kinase
KM389_11000	COG1070	Carbohydrate kinase
KM389_11030	COG0517	IMP dehydrogenase activity
KM389_11030	COG1125	glycine betaine transport
KM389_11035	COG1174	glycine betaine transport
KM389_11070	COG1253	flavin adenine dinucleotide binding
KM389_11075	COG1012	belongs to the aldehyde dehydrogenase family
KM389_11080	COG5506	Protein of unknown function (DUF1694)
KM389_11095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM389_11100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KM389_11105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KM389_11110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KM389_11115	COG0456	acetyltransferase
KM389_11120	COG3829	transcription factor binding
KM389_11125	COG1509	lysine 2,3-aminomutase activity
KM389_11165	COG4326	sporulation control protein
KM389_11170	COG0671	phosphoesterase, PA-phosphatase related
KM389_11175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM389_11180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM389_11210	COG1787	Restriction endonuclease
KM389_11210	COG1715	Restriction endonuclease
KM389_11300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KM389_11340	COG4499	WXG100 protein secretion system (Wss), protein YukC
KM389_11340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM389_11345	COG2814	Major facilitator Superfamily
KM389_11350	COG4841	protein insertion into membrane
KM389_11355	COG0372	Belongs to the citrate synthase family
KM389_11360	COG2079	MmgE PrpD family protein
KM389_11365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KM389_11370	COG1960	acyl-CoA dehydrogenase activity
KM389_11375	COG2084	Dehydrogenase
KM389_11385	COG1280	lysine exporter protein (LysE YggA)
KM389_11390	COG1024	Enoyl-CoA hydratase
KM389_11405	COG0420	3'-5' exonuclease activity
KM389_11410	COG0419	ATPase involved in DNA repair
KM389_11430	COG2223	nitrite transmembrane transporter activity
KM389_11435	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_11440	COG1169	isochorismate synthase
KM389_11445	COG1021	2,3-dihydroxybenzoate-AMP ligase
KM389_11450	COG3433	isochorismatase activity
KM389_11450	COG1535	isochorismatase
KM389_11455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KM389_11460	COG3251	PFAM MbtH domain protein
KM389_11465	COG2814	Major facilitator Superfamily
KM389_11480	COG0776	regulation of translation
KM389_11490	COG2318	DinB family
KM389_11500	COG1115	amino acid carrier protein
KM389_11515	COG2329	Antibiotic biosynthesis monooxygenase
KM389_11520	COG1187	pseudouridine synthase activity
KM389_11525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM389_11540	COG0596	Alpha beta hydrolase
KM389_11545	COG2814	Major facilitator Superfamily
KM389_11565	COG2226	methyltransferase
KM389_11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_11645	COG1247	-acetyltransferase
KM389_11675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KM389_11685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_11695	COG1278	Cold shock
KM389_11710	COG0010	Belongs to the arginase family
KM389_11715	COG0561	phosphatase activity
KM389_11760	COG0583	DNA-binding transcription factor activity
KM389_11765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM389_11780	COG0583	DNA-binding transcription factor activity
KM389_11785	COG2258	MOSC domain
KM389_11800	COG1132	(ABC) transporter
KM389_11805	COG1132	(ABC) transporter
KM389_11825	COG1396	sequence-specific DNA binding
KM389_11850	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
KM389_11855	COG1595	DNA-templated transcription, initiation
KM389_11880	COG1649	PFAM Uncharacterised BCR, COG1649
KM389_11905	COG2971	BadF BadG BcrA BcrD
KM389_11910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM389_11915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KM389_11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_11965	COG1309	transcriptional regulator
KM389_11980	COG1136	(ABC) transporter
KM389_11980	COG0577	efflux transmembrane transporter activity
KM389_11985	COG0500	methyltransferase
KM389_11985	COG3615	Tellurite resistance protein tehB
KM389_11995	COG2226	methyltransferase
KM389_12000	COG3961	Belongs to the TPP enzyme family
KM389_12005	COG1846	Transcriptional regulator
KM389_12045	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM389_12060	COG1595	DNA-templated transcription, initiation
KM389_12070	COG0768	penicillin binding
KM389_12080	COG2367	Beta-lactamase
KM389_12085	COG0671	phosphoesterase, PA-phosphatase related
KM389_12090	COG1609	Transcriptional regulator
KM389_12095	COG2814	Major facilitator Superfamily
KM389_12100	COG0673	inositol 2-dehydrogenase activity
KM389_12110	COG1012	belongs to the aldehyde dehydrogenase family
KM389_12125	COG0191	fructose-bisphosphate aldolase activity
KM389_12130	COG3718	enzyme involved in inositol metabolism
KM389_12155	COG0457	Tetratricopeptide repeat
KM389_12160	COG1476	TRANSCRIPTIONal
KM389_12175	COG1876	peptidase activity
KM389_12195	COG1309	transcriptional regulator
KM389_12200	COG0488	(ABC) transporter
KM389_12215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_12230	COG1252	NADH dehydrogenase
KM389_12235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_12250	COG1131	(ABC) transporter
KM389_12260	COG1309	transcriptional regulator
KM389_12275	COG1960	acyl-CoA dehydrogenase activity
KM389_12280	COG0439	Biotin carboxylase
KM389_12285	COG0511	ligase activity, forming carbon-carbon bonds
KM389_12290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KM389_12295	COG1024	Enoyl-CoA hydratase
KM389_12300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KM389_12305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM389_12315	COG1247	-acetyltransferase
KM389_12320	COG0572	uridine kinase
KM389_12330	COG2318	DinB family
KM389_12335	COG1686	Belongs to the peptidase S11 family
KM389_12360	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KM389_12400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM389_12400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM389_12425	COG2814	Major facilitator Superfamily
KM389_12445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM389_12465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_12480	COG1063	alcohol dehydrogenase
KM389_12510	COG3773	Cell wall hydrolase
KM389_12520	COG0745	RESPONSE REGULATOR receiver
KM389_12535	COG0488	(ABC) transporter
KM389_12550	COG1136	(ABC) transporter
KM389_12575	COG0460	homoserine dehydrogenase
KM389_12580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_12590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KM389_12655	COG2124	cytochrome p450
KM389_12690	COG0561	phosphatase activity
KM389_12700	COG5002	protein histidine kinase activity
KM389_12705	COG0768	penicillin binding
KM389_12710	COG1819	glycosyl
KM389_12715	COG1794	racemase activity, acting on amino acids and derivatives
KM389_12725	COG1122	ATPase activity
KM389_12740	COG2205	protein histidine kinase activity
KM389_12750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM389_12755	COG0604	alcohol dehydrogenase
KM389_12760	COG0768	penicillin binding
KM389_12770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM389_12805	COG0693	protein deglycase activity
KM389_12835	COG2814	Major facilitator Superfamily
KM389_12850	COG0584	glycerophosphoryl diester phosphodiesterase
KM389_12870	COG0697	spore germination
KM389_12895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM389_12905	COG2223	nitrite transmembrane transporter activity
KM389_12920	COG2816	NAD+ diphosphatase activity
KM389_12925	COG0592	DNA-directed DNA polymerase activity
KM389_12930	COG1051	belongs to the nudix hydrolase family
KM389_12965	COG3878	Protein conserved in bacteria
KM389_13010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KM389_13025	COG0322	excinuclease ABC activity
KM389_13065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM389_13090	COG1011	Hydrolase
KM389_13110	COG0076	glutamate decarboxylase activity
KM389_13125	COG1523	belongs to the glycosyl hydrolase 13 family
KM389_13130	COG3227	Zinc metalloprotease (Elastase)
KM389_13150	COG0201	protein transport
KM389_13160	COG0697	spore germination
KM389_13165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_13195	COG4129	membrane
KM389_13200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_13215	COG2959	enzyme of heme biosynthesis
KM389_13235	COG3483	tryptophan 2,3-dioxygenase activity
KM389_13240	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KM389_13245	COG3844	kynureninase activity
KM389_13250	COG1309	transcriptional regulator
KM389_13280	COG3284	Transcriptional regulator
KM389_13300	COG1349	DNA-binding transcription factor activity
KM389_13320	COG1959	2 iron, 2 sulfur cluster binding
KM389_13335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM389_13340	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM389_13345	COG0022	dehydrogenase e1 component
KM389_13350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM389_13360	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_13365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM389_13365	COG0456	acetyltransferase
KM389_13400	COG4175	Glycine betaine
KM389_13400	COG0517	IMP dehydrogenase activity
KM389_13425	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KM389_13430	COG2153	protein acetylation
KM389_13435	COG3397	chitin binding
KM389_13450	COG2205	protein histidine kinase activity
KM389_13475	COG0658	competence protein
KM389_13475	COG2333	competence protein COMEC
KM389_13525	COG3973	AAA domain
KM389_13540	COG2105	PFAM AIG2 family protein
KM389_13545	COG0514	ATP-dependent DNA helicase (RecQ)
KM389_13565	COG4637	Psort location Cytoplasmic, score
KM389_13590	COG3397	chitin binding
KM389_13605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KM389_13610	COG1115	amino acid carrier protein
KM389_13615	COG1012	belongs to the aldehyde dehydrogenase family
KM389_13620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KM389_13630	COG3938	Belongs to the proline racemase family
KM389_13635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KM389_13675	COG0586	Pfam SNARE associated Golgi protein
KM389_13690	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KM389_13695	COG0519	Catalyzes the synthesis of GMP from XMP
KM389_13700	COG4166	transmembrane transport
KM389_13710	COG4948	Mandelate Racemase Muconate Lactonizing
KM389_13755	COG2936	dipeptidyl-peptidase activity
KM389_13760	COG5002	protein histidine kinase activity
KM389_13800	COG1164	Oligoendopeptidase f
KM389_13815	COG1307	EDD domain protein, DegV family
KM389_13835	COG2814	Major facilitator Superfamily
KM389_13845	COG1664	Polymer-forming cytoskeletal
KM389_13850	COG0789	Transcriptional regulator
KM389_13855	COG4533	DNA binding
KM389_13860	COG2814	Major facilitator Superfamily
KM389_13860	COG0477	Major facilitator Superfamily
KM389_13880	COG2261	transglycosylase associated protein
KM389_13895	COG2226	methyltransferase
KM389_13930	COG0436	Aminotransferase
KM389_13935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KM389_13940	COG5146	pantothenate kinase activity
KM389_13960	COG1131	(ABC) transporter
KM389_14005	COG0628	permease
KM389_14015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM389_14020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM389_14025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM389_14030	COG1116	anion transmembrane transporter activity
KM389_14050	COG2816	NAD+ diphosphatase activity
KM389_14095	COG0697	spore germination
KM389_14100	COG2318	DinB family
KM389_14120	COG4912	Dna alkylation repair
KM389_14140	COG0861	Integral membrane protein TerC family
KM389_14145	COG1368	sulfuric ester hydrolase activity
KM389_14150	COG0488	(ABC) transporter
KM389_14160	COG1033	growth of symbiont in host cell
KM389_14160	COG2409	Drug exporters of the RND superfamily
KM389_14165	COG1033	growth of symbiont in host cell
KM389_14165	COG2409	Drug exporters of the RND superfamily
KM389_14170	COG1033	growth of symbiont in host cell
KM389_14170	COG2409	Drug exporters of the RND superfamily
KM389_14175	COG1309	transcriptional regulator
KM389_14190	COG0287	Prephenate dehydrogenase
KM389_14195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KM389_14200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KM389_14205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KM389_14205	COG1605	Chorismate mutase
KM389_14240	COG3584	3D domain protein
KM389_14240	COG1388	LysM domain
KM389_14250	COG1595	DNA-templated transcription, initiation
KM389_14275	COG1879	ABC-type sugar transport system periplasmic component
KM389_14285	COG1172	Belongs to the binding-protein-dependent transport system permease family
KM389_14295	COG2390	Transcriptional regulator
KM389_14330	COG2329	Antibiotic biosynthesis monooxygenase
KM389_14350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_14360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KM389_14365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM389_14370	COG4187	Peptidase family M20/M25/M40
KM389_14375	COG1414	Transcriptional regulator
KM389_14380	COG0833	amino acid
KM389_14385	COG1690	Belongs to the RtcB family
KM389_14390	COG3239	Fatty acid desaturase
KM389_14395	COG1785	Belongs to the alkaline phosphatase family
KM389_14405	COG3655	Transcriptional regulator
KM389_14420	COG4377	Putative membrane peptidase family (DUF2324)
KM389_14430	COG3279	Response regulator of the LytR AlgR family
KM389_14440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_14445	COG0346	lactoylglutathione lyase activity
KM389_14465	COG0714	Associated with various cellular activities
KM389_14490	COG0463	Glycosyl transferase, family 2
KM389_14515	COG0463	Glycosyl transferase, family 2
KM389_14525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM389_14530	COG0753	catalase activity
KM389_14540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KM389_14565	COG0714	Associated with various cellular activities
KM389_14575	COG0778	Nitroreductase
KM389_14580	COG1846	Transcriptional regulator
KM389_14615	COG1725	Transcriptional regulator
KM389_14625	COG1136	(ABC) transporter
KM389_14625	COG0577	efflux transmembrane transporter activity
KM389_14650	COG2207	Transcriptional regulator
KM389_14655	COG0456	acetyltransferase
KM389_14675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_14695	COG0642	Histidine kinase
KM389_14700	COG0745	RESPONSE REGULATOR receiver
KM389_14705	COG0596	Alpha beta hydrolase
KM389_14735	COG0730	response to heat
KM389_14745	COG0833	amino acid
KM389_14755	COG4335	DNA alkylation repair
KM389_14795	COG0768	penicillin binding
KM389_14805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KM389_14835	COG1984	allophanate hydrolase subunit 2
KM389_14840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KM389_14845	COG1414	Transcriptional regulator
KM389_14860	COG0860	N-Acetylmuramoyl-L-alanine amidase
KM389_14865	COG0640	Transcriptional regulator
KM389_14875	COG1960	acyl-CoA dehydrogenase activity
KM389_14890	COG3314	Sporulation integral membrane protein YlbJ
KM389_14905	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KM389_14920	COG0574	Belongs to the PEP-utilizing enzyme family
KM389_14920	COG3848	Pyruvate phosphate dikinase
KM389_14925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_14940	COG5577	PFAM Coat F domain
KM389_14945	COG3403	YqcI/YcgG family
KM389_14950	COG1280	lysine exporter protein (LysE YggA)
KM389_14985	COG1063	alcohol dehydrogenase
KM389_15000	COG1027	Aspartate ammonia-lyase
KM389_15005	COG0252	asparaginase activity
KM389_15010	COG1396	sequence-specific DNA binding
KM389_15020	COG0322	excinuclease ABC activity
KM389_15025	COG0531	amino acid
KM389_15030	COG1114	Component of the transport system for branched-chain amino acids
KM389_15035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM389_15045	COG0281	malic enzyme
KM389_15060	COG0531	amino acid
KM389_15080	COG2066	Belongs to the glutaminase family
KM389_15085	COG1115	amino acid carrier protein
KM389_15115	COG0737	Belongs to the 5'-nucleotidase family
KM389_15120	COG0753	catalase activity
KM389_15125	COG2267	carboxylic ester hydrolase activity
KM389_15130	COG1335	isochorismatase
KM389_15150	COG0583	DNA-binding transcription factor activity
KM389_15155	COG1846	Transcriptional regulator
KM389_15195	COG0415	Belongs to the DNA photolyase family
KM389_15200	COG0288	reversible hydration of carbon dioxide
KM389_15210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM389_15215	COG5609	conserved protein (DUF2294)
KM389_15230	COG1575	Belongs to the MenA family. Type 1 subfamily
KM389_15235	COG2267	carboxylic ester hydrolase activity
KM389_15240	COG0803	Belongs to the bacterial solute-binding protein 9 family
KM389_15245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM389_15250	COG1121	(ABC) transporter
KM389_15280	COG0798	PFAM Bile acid sodium symporter
KM389_15285	COG0346	lactoylglutathione lyase activity
KM389_15290	COG0640	Transcriptional regulator
KM389_15305	COG0443	Heat shock 70 kDa protein
KM389_15320	COG1522	sequence-specific DNA binding
KM389_15335	COG0346	lactoylglutathione lyase activity
KM389_15360	COG2169	Transcriptional regulator
KM389_15405	COG2814	Major facilitator Superfamily
KM389_15430	COG0745	RESPONSE REGULATOR receiver
KM389_15435	COG5002	protein histidine kinase activity
KM389_15435	COG3850	Histidine kinase
KM389_15460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KM389_15480	COG1476	TRANSCRIPTIONal
KM389_15495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_15500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KM389_15510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_15515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KM389_15530	COG1136	(ABC) transporter
KM389_15535	COG0577	efflux transmembrane transporter activity
KM389_15550	COG5002	protein histidine kinase activity
KM389_15550	COG3850	Histidine kinase
KM389_15560	COG2364	Membrane
KM389_15565	COG1846	Transcriptional regulator
KM389_15575	COG2808	Putative FMN-binding domain
KM389_15580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_15585	COG2271	Major facilitator Superfamily
KM389_15590	COG1556	Lactate utilization protein
KM389_15595	COG1139	Iron-sulfur cluster binding protein
KM389_15605	COG0583	DNA-binding transcription factor activity
KM389_15615	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM389_15635	COG0738	Major facilitator superfamily
KM389_15640	COG0673	inositol 2-dehydrogenase activity
KM389_15645	COG0561	phosphatase activity
KM389_15655	COG1609	Transcriptional regulator
KM389_15660	COG0457	Tetratricopeptide repeat
KM389_15680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM389_15710	COG0534	Mate efflux family protein
KM389_15730	COG2814	Major facilitator Superfamily
KM389_15735	COG1309	transcriptional regulator
KM389_15750	COG0814	amino acid
KM389_15755	COG1760	l-serine dehydratase
KM389_15760	COG1760	l-serine dehydratase
KM389_15770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KM389_15775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KM389_15785	COG1335	isochorismatase
KM389_15790	COG1522	sequence-specific DNA binding
KM389_15795	COG0531	amino acid
KM389_15810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KM389_15830	COG1595	DNA-templated transcription, initiation
KM389_15845	COG0662	Cupin 2, conserved barrel domain protein
KM389_15850	COG2207	Transcriptional regulator
KM389_15850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_15900	COG0477	Major facilitator Superfamily
KM389_15910	COG1846	Transcriptional regulator
KM389_15915	COG2814	Major facilitator Superfamily
KM389_15925	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM389_15930	COG1131	(ABC) transporter
KM389_15950	COG2076	Multidrug Resistance protein
KM389_15955	COG1309	transcriptional regulator
KM389_15965	COG2031	fatty acid transporter
KM389_15975	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM389_16005	COG1122	ATPase activity
KM389_16010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KM389_16025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KM389_16030	COG1288	antiporter activity
KM389_16035	COG2356	endonuclease I
KM389_16050	COG3620	sequence-specific DNA binding
KM389_16055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM389_16060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KM389_16065	COG0124	histidyl-tRNA synthetase
KM389_16080	COG1733	regulation of RNA biosynthetic process
KM389_16085	COG0778	Nitroreductase
KM389_16105	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_16115	COG1131	(ABC) transporter
KM389_16140	COG1011	Hydrolase
KM389_16150	COG2365	Tyrosine phosphatase family
KM389_16175	COG0346	lactoylglutathione lyase activity
KM389_16180	COG1940	carbohydrate kinase activity
KM389_16185	COG0738	Major facilitator superfamily
KM389_16190	COG0110	maltose O-acetyltransferase activity
KM389_16200	COG1136	(ABC) transporter
KM389_16200	COG0577	efflux transmembrane transporter activity
KM389_16215	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KM389_16220	COG0628	permease
KM389_16240	COG2226	methyltransferase
KM389_16250	COG0477	Major facilitator Superfamily
KM389_16280	COG1253	flavin adenine dinucleotide binding
KM389_16285	COG0789	Transcriptional regulator
KM389_16290	COG0697	spore germination
KM389_16295	COG1357	PFAM Pentapeptide repeats (8 copies)
KM389_16300	COG3813	Protein conserved in bacteria
KM389_16305	COG2706	6-phosphogluconolactonase activity
KM389_16310	COG1070	Carbohydrate kinase
KM389_16320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KM389_16325	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
KM389_16335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM389_16340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KM389_16345	COG0604	alcohol dehydrogenase
KM389_16350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KM389_16360	COG0604	alcohol dehydrogenase
KM389_16360	COG3321	synthase
KM389_16365	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_16390	COG0656	L-ascorbic acid biosynthetic process
KM389_16395	COG2814	Major facilitator Superfamily
KM389_16410	COG0346	lactoylglutathione lyase activity
KM389_16415	COG0814	amino acid
KM389_16440	COG1393	Belongs to the ArsC family
KM389_16445	COG1733	regulation of RNA biosynthetic process
KM389_16450	COG2188	Transcriptional regulator
KM389_16460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KM389_16465	COG1733	regulation of RNA biosynthetic process
KM389_16470	COG1733	regulation of RNA biosynthetic process
KM389_16485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_16505	COG0384	phenazine biosynthesis protein PhzF
KM389_16515	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_16525	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_16535	COG1733	regulation of RNA biosynthetic process
KM389_16570	COG1191	sigma factor activity
KM389_16585	COG1309	transcriptional regulator
KM389_16605	COG3152	Membrane
KM389_16630	COG1151	hydroxylamine reductase activity
KM389_16640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_16645	COG3757	hydrolase, family 25
KM389_16645	COG3409	Peptidoglycan-binding domain 1 protein
KM389_16680	COG2072	flavoprotein involved in K transport
KM389_16715	COG0604	alcohol dehydrogenase
KM389_16720	COG1113	amino acid transport
KM389_16725	COG2814	Major facilitator Superfamily
KM389_16755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM389_16760	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM389_16780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_16785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_16790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_16795	COG3739	integral membrane protein
KM389_16800	COG0384	phenazine biosynthesis protein PhzF
KM389_16830	COG0583	DNA-binding transcription factor activity
KM389_16850	COG1193	negative regulation of DNA recombination
KM389_16875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KM389_16905	COG0584	glycerophosphoryl diester phosphodiesterase
KM389_16930	COG0640	Transcriptional regulator
KM389_16935	COG0604	alcohol dehydrogenase
KM389_16955	COG2808	Putative FMN-binding domain
KM389_16960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM389_16970	COG0385	Bile acid
KM389_16975	COG0277	FAD linked oxidase domain protein
KM389_17005	COG1216	Glycosyl transferase, family 2
KM389_17010	COG1024	Enoyl-CoA hydratase
KM389_17020	COG1285	pathogenesis
KM389_17035	COG2514	catechol 2,3-dioxygenase activity
KM389_17040	COG2720	vancomycin resistance protein
KM389_17080	COG0716	FMN binding
KM389_17110	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_17120	COG0165	Argininosuccinate lyase
KM389_17135	COG4145	pantothenate transmembrane transporter activity
KM389_17145	COG1012	belongs to the aldehyde dehydrogenase family
KM389_17150	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_17160	COG1657	PFAM Prenyltransferase squalene oxidase
KM389_17165	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KM389_17170	COG2962	Rard protein
KM389_17175	COG3326	Membrane
KM389_17190	COG0489	protein tyrosine kinase activity
KM389_17200	COG0314	molybdopterin synthase activity
KM389_17205	COG0303	'Molybdopterin
KM389_17210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM389_17215	COG2116	formate transmembrane transporter activity
KM389_17225	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KM389_17230	COG5609	conserved protein (DUF2294)
KM389_17235	COG2427	Protein of unknown function (DUF1641)
KM389_17240	COG3383	formate dehydrogenase (NAD+) activity
KM389_17245	COG0697	spore germination
KM389_17285	COG2226	methyltransferase
KM389_17290	COG4166	transmembrane transport
KM389_17295	COG4166	transmembrane transport
KM389_17300	COG4166	transmembrane transport
KM389_17305	COG1301	dicarboxylic acid transport
KM389_17310	COG1316	TRANSCRIPTIONal
KM389_17320	COG1595	DNA-templated transcription, initiation
KM389_17340	COG1131	(ABC) transporter
KM389_17350	COG0673	inositol 2-dehydrogenase activity
KM389_17355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KM389_17360	COG0187	DNA topoisomerase II activity
KM389_17365	COG1832	CoA-binding protein
KM389_17370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM389_17375	COG0745	RESPONSE REGULATOR receiver
KM389_17390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KM389_17395	COG4841	protein insertion into membrane
KM389_17400	COG0824	Thioesterase
KM389_17430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM389_17440	COG2274	protein secretion by the type I secretion system
KM389_17445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KM389_17485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM389_17500	COG0183	Belongs to the thiolase family
KM389_17505	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_17510	COG1268	BioY protein
KM389_17515	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_17565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_17575	COG5002	protein histidine kinase activity
KM389_17580	COG0400	carboxylic ester hydrolase activity
KM389_17585	COG0346	lactoylglutathione lyase activity
KM389_17590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KM389_17595	COG0069	glutamate synthase activity
KM389_17600	COG1902	pentaerythritol trinitrate reductase activity
KM389_17605	COG1329	Transcriptional regulator
KM389_17610	COG0010	Belongs to the arginase family
KM389_17635	COG2226	methyltransferase
KM389_17690	COG4846	Membrane protein involved in cytochrome C biogenesis
KM389_17695	COG0785	Cytochrome C biogenesis protein
KM389_17705	COG0583	DNA-binding transcription factor activity
KM389_17710	COG1380	Effector of murein hydrolase LrgA
KM389_17715	COG1346	cytolysis
KM389_17740	COG3409	Peptidoglycan-binding domain 1 protein
KM389_17740	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM389_17755	COG1132	(ABC) transporter
KM389_17760	COG1132	(ABC) transporter
KM389_17790	COG3639	organic phosphonate transmembrane transporter activity
KM389_17795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KM389_17815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KM389_17835	COG1695	Transcriptional regulator
KM389_17870	COG5632	N-Acetylmuramoyl-L-alanine amidase
KM389_17870	COG3409	Peptidoglycan-binding domain 1 protein
KM389_17870	COG1388	LysM domain
KM389_17875	COG4824	toxin secretion phage lysis holin
KM389_18030	COG1595	DNA-templated transcription, initiation
KM389_18075	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KM389_18155	COG1396	sequence-specific DNA binding
KM389_18180	COG0174	glutamine synthetase
KM389_18185	COG0789	Transcriptional regulator
KM389_18190	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KM389_18200	COG2860	membrane
KM389_18210	COG0464	growth
KM389_18240	COG3584	3D domain protein
KM389_18240	COG1388	LysM domain
KM389_18245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM389_18245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM389_18245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KM389_18250	COG1105	Belongs to the carbohydrate kinase PfkB family
KM389_18255	COG1349	DNA-binding transcription factor activity
KM389_18265	COG2322	membrane
KM389_18275	COG1113	amino acid transport
KM389_18290	COG1408	metallophosphoesterase
KM389_18295	COG2116	formate transmembrane transporter activity
KM389_18305	COG2217	Heavy metal translocating P-type atpase
KM389_18310	COG2608	mercury ion transmembrane transporter activity
KM389_18315	COG1937	Protein conserved in bacteria
KM389_18325	COG2819	hydrolase of the alpha beta superfamily
KM389_18330	COG1120	ATPase activity
KM389_18335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_18340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_18350	COG0708	Exodeoxyribonuclease III
KM389_18355	COG2169	Transcriptional regulator
KM389_18360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KM389_18365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KM389_18375	COG2364	Membrane
KM389_18390	COG2267	carboxylic ester hydrolase activity
KM389_18395	COG0346	lactoylglutathione lyase activity
KM389_18400	COG5001	Diguanylate cyclase
KM389_18400	COG3300	MHYT domain
KM389_18415	COG1346	cytolysis
KM389_18420	COG1380	Effector of murein hydrolase LrgA
KM389_18425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KM389_18430	COG0596	Alpha beta hydrolase
KM389_18430	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM389_18435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KM389_18455	COG1404	Belongs to the peptidase S8 family
KM389_18460	COG3773	Cell wall hydrolase
KM389_18465	COG0562	UDP-galactopyranose mutase
KM389_18470	COG1368	sulfuric ester hydrolase activity
KM389_18475	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KM389_18485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KM389_18510	COG1131	(ABC) transporter
KM389_18530	COG4550	Control of competence regulator ComK, YlbF/YmcA
KM389_18535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM389_18540	COG1013	pyruvate-flavodoxin oxidoreductase activity
KM389_18545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KM389_18545	COG0674	pyruvate-flavodoxin oxidoreductase activity
KM389_18555	COG2359	stage V sporulation protein S
KM389_18560	COG1692	metallophosphoesterase
KM389_18585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KM389_18590	COG1426	Protein conserved in bacteria
KM389_18605	COG0300	oxidoreductase activity
KM389_18610	COG0612	Peptidase, M16
KM389_18615	COG0612	Peptidase, M16
KM389_18620	COG1079	Belongs to the binding-protein-dependent transport system permease family
KM389_18630	COG3845	ABC transporter
KM389_18635	COG1744	ABC transporter substrate-binding protein PnrA-like
KM389_18640	COG2188	Transcriptional regulator
KM389_18645	COG1674	ftsk spoiiie
KM389_18655	COG0740	serine-type endopeptidase activity
KM389_18660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM389_18670	COG0527	aspartate kinase activity
KM389_18675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KM389_18680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM389_18685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM389_18690	COG1873	PFAM PRC-barrel domain
KM389_18695	COG0612	Peptidase, M16
KM389_18700	COG0726	polysaccharide deacetylase
KM389_18715	COG0196	riboflavin kinase activity
KM389_18720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KM389_18730	COG1550	Protein conserved in bacteria
KM389_18740	COG1358	cellular component organization or biogenesis
KM389_18745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KM389_18750	COG0195	Participates in both transcription termination and antitermination
KM389_18770	COG0750	zinc metalloprotease
KM389_18780	COG4589	Belongs to the CDS family
KM389_18785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KM389_18795	COG0528	UMP kinase activity
KM389_18825	COG4974	Belongs to the 'phage' integrase family
KM389_18835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM389_18845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KM389_18885	COG1837	Belongs to the UPF0109 family
KM389_18895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KM389_18905	COG0552	protein localization to endoplasmic reticulum
KM389_18910	COG1196	nuclear chromosome segregation
KM389_18920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KM389_18925	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_18930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KM389_18945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KM389_18950	COG1461	Dihydroxyacetone kinase
KM389_18955	COG1302	Protein conserved in bacteria
KM389_18970	COG1564	THIamine pyrophosphokinase
KM389_18975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KM389_18980	COG1162	GTPase activity
KM389_18985	COG0515	serine threonine protein kinase
KM389_18985	COG2815	serine threonine protein kinase
KM389_18990	COG0631	protein serine/threonine phosphatase activity
KM389_19000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KM389_19000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KM389_19010	COG0242	peptide deformylase activity
KM389_19015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KM389_19020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KM389_19040	COG1561	YicC-like family, N-terminal region
KM389_19045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KM389_19055	COG0006	proline dipeptidase activity
KM389_19070	COG3069	C4-dicarboxylate transmembrane transporter activity
KM389_19135	COG0564	pseudouridine synthase activity
KM389_19155	COG3599	regulation of cell shape
KM389_19160	COG2302	S4 RNA-binding domain
KM389_19165	COG0762	integral membrane protein
KM389_19175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KM389_19180	COG1496	oxidoreductase activity
KM389_19185	COG1873	PFAM PRC-barrel domain
KM389_19190	COG1191	sigma factor activity
KM389_19195	COG1191	sigma factor activity
KM389_19205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KM389_19210	COG0849	cell division
KM389_19215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KM389_19220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM389_19230	COG0772	Belongs to the SEDS family
KM389_19245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KM389_19250	COG0768	penicillin binding
KM389_19255	COG0768	penicillin binding
KM389_19260	COG4839	cell division protein FtsL
KM389_19275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KM389_19290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KM389_19295	COG1399	metal-binding, possibly nucleic acid-binding protein
KM389_19345	COG4824	toxin secretion phage lysis holin
KM389_19430	COG1802	Transcriptional regulator
KM389_19430	COG4626	Terminase
KM389_19455	COG0582	viral genome integration into host DNA
KM389_19520	COG0756	dUTP diphosphatase activity
KM389_19535	COG1191	sigma factor activity
KM389_19560	COG1484	DNA-dependent DNA replication
KM389_19590	COG1396	sequence-specific DNA binding
KM389_19605	COG1396	sequence-specific DNA binding
KM389_19620	COG0582	viral genome integration into host DNA
KM389_19630	COG3480	Lon protease (S16) C-terminal proteolytic domain
KM389_19635	COG1752	Esterase of the alpha-beta hydrolase superfamily
KM389_19640	COG3314	Sporulation integral membrane protein YlbJ
KM389_19650	COG0742	ribosomal rna small subunit methyltransferase
KM389_19665	COG3679	Belongs to the UPF0342 family
KM389_19670	COG0406	alpha-ribazole phosphatase activity
KM389_19685	COG2340	Cysteine-rich secretory protein family
KM389_19700	COG3336	cytochrome c oxidase
KM389_19735	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KM389_19740	COG0772	Belongs to the SEDS family
KM389_19750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KM389_19755	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KM389_19765	COG4896	Protein conserved in bacteria
KM389_19780	COG1217	gtp-binding protein TYPA
KM389_19790	COG0483	inositol monophosphate 1-phosphatase activity
KM389_19810	COG1982	Orn Lys Arg decarboxylase major
KM389_19855	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM389_19860	COG0022	dehydrogenase e1 component
KM389_19865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM389_19875	COG0242	peptide deformylase activity
KM389_19880	COG0561	phosphatase activity
KM389_19890	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KM389_19895	COG0569	domain protein
KM389_19915	COG0583	DNA-binding transcription factor activity
KM389_19920	COG0517	IMP dehydrogenase activity
KM389_19930	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KM389_19940	COG4703	Protein of unknown function (DUF1797)
KM389_19955	COG2200	EAL domain
KM389_19960	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_19965	COG1408	metallophosphoesterase
KM389_19975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KM389_20010	COG2814	Major facilitator Superfamily
KM389_20030	COG3209	COG3209 Rhs family protein
KM389_20040	COG2205	protein histidine kinase activity
KM389_20050	COG0436	Aminotransferase
KM389_20060	COG3833	ABC-type maltose transport systems, permease component
KM389_20065	COG1175	transmembrane transport
KM389_20070	COG2182	Extracellular solute-binding protein
KM389_20080	COG0366	Alpha amylase catalytic
KM389_20085	COG3842	ATPase activity
KM389_20160	COG1695	Transcriptional regulator
KM389_20165	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_20175	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KM389_20185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KM389_20190	COG0436	Aminotransferase
KM389_20210	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KM389_20230	COG2199	diguanylate cyclase activity
KM389_20235	COG0778	Nitroreductase
KM389_20260	COG1263	PTS System
KM389_20260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KM389_20260	COG2190	(PTS) system
KM389_20265	COG3711	transcriptional antiterminator
KM389_20275	COG2188	Transcriptional regulator
KM389_20285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KM389_20310	COG1547	Domain of unknown function (DUF309)
KM389_20315	COG0456	acetyltransferase
KM389_20320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KM389_20325	COG4086	secreted protein
KM389_20330	COG0561	phosphatase activity
KM389_20335	COG0697	spore germination
KM389_20350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_20375	COG0733	neurotransmitter:sodium symporter activity
KM389_20395	COG1686	Belongs to the peptidase S11 family
KM389_20400	COG1725	Transcriptional regulator
KM389_20405	COG1131	(ABC) transporter
KM389_20420	COG1846	Transcriptional regulator
KM389_20435	COG0598	Magnesium transport protein CorA
KM389_20460	COG4974	Belongs to the 'phage' integrase family
KM389_20470	COG0735	belongs to the Fur family
KM389_20475	COG1300	Membrane
KM389_20495	COG0667	Aldo Keto reductase
KM389_20500	COG0656	L-ascorbic acid biosynthetic process
KM389_20505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KM389_20505	COG0456	acetyltransferase
KM389_20515	COG0737	Belongs to the 5'-nucleotidase family
KM389_20515	COG4085	toxin activity
KM389_20515	COG1525	nuclease
KM389_20525	COG0596	Alpha beta hydrolase
KM389_20530	COG2056	Na+-H+ antiporter family
KM389_20535	COG1609	Transcriptional regulator
KM389_20540	COG0456	acetyltransferase
KM389_20545	COG1073	alpha beta
KM389_20560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM389_20560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KM389_20565	COG0307	riboflavin synthase, alpha
KM389_20590	COG4106	trans-aconitate 2-methyltransferase activity
KM389_20595	COG2226	methyltransferase
KM389_20595	COG1073	alpha beta
KM389_20610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KM389_20620	COG1757	Na H antiporter
KM389_20625	COG0737	Belongs to the 5'-nucleotidase family
KM389_20635	COG1522	sequence-specific DNA binding
KM389_20655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KM389_20665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KM389_20680	COG0300	oxidoreductase activity
KM389_20690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM389_20695	COG1760	l-serine dehydratase
KM389_20700	COG1760	l-serine dehydratase
KM389_20720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM389_20730	COG2195	Cleaves the N-terminal amino acid of tripeptides
KM389_20735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_20750	COG1376	ErfK ybiS ycfS ynhG family protein
KM389_20755	COG4129	membrane
KM389_20760	COG1126	abc transporter atp-binding protein
KM389_20765	COG0765	amino acid transport
KM389_20770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KM389_20790	COG0772	Belongs to the SEDS family
KM389_20795	COG0508	dehydrogenase complex catalyzes the overall conversion of
KM389_20800	COG0022	dehydrogenase e1 component
KM389_20805	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KM389_20810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KM389_20825	COG0280	phosphate acetyltransferase
KM389_20830	COG3290	protein histidine kinase activity
KM389_20830	COG3829	transcription factor binding
KM389_20840	COG0584	glycerophosphoryl diester phosphodiesterase
KM389_20845	COG3093	addiction module antidote protein HigA
KM389_20855	COG0745	RESPONSE REGULATOR receiver
KM389_20860	COG0750	zinc metalloprotease
KM389_20865	COG0497	DNA recombination
KM389_20875	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KM389_20885	COG0142	geranyltranstransferase activity
KM389_20910	COG1302	Protein conserved in bacteria
KM389_20915	COG0439	Biotin carboxylase
KM389_20920	COG0511	ligase activity, forming carbon-carbon bonds
KM389_20965	COG3854	ATPases associated with a variety of cellular activities
KM389_20990	COG0006	proline dipeptidase activity
KM389_21005	COG3872	metal-dependent enzyme
KM389_21015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KM389_21035	COG0095	Lipoate-protein ligase
KM389_21040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_21045	COG1609	Transcriptional regulator
KM389_21055	COG2076	Multidrug Resistance protein
KM389_21060	COG2076	Multidrug Resistance protein
KM389_21095	COG1131	(ABC) transporter
KM389_21100	COG1725	Transcriptional regulator
KM389_21130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM389_21185	COG4970	Tfp pilus assembly protein FimT
KM389_21195	COG1459	type II secretion system
KM389_21200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KM389_21250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KM389_21255	COG0646	methionine synthase
KM389_21255	COG1410	methionine synthase
KM389_21260	COG0646	methionine synthase
KM389_21260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KM389_21265	COG0626	cystathionine gamma-synthase activity
KM389_21270	COG0626	cystathionine gamma-synthase activity
KM389_21290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_21300	COG1940	carbohydrate kinase activity
KM389_21305	COG4483	Protein conserved in bacteria
KM389_21310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KM389_21315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KM389_21320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KM389_21325	COG0704	Plays a role in the regulation of phosphate uptake
KM389_21335	COG0581	inorganic phosphate transmembrane transporter activity
KM389_21340	COG0573	inorganic phosphate transmembrane transporter activity
KM389_21345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KM389_21350	COG0768	penicillin binding
KM389_21355	COG0477	Major facilitator Superfamily
KM389_21360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM389_21385	COG0735	belongs to the Fur family
KM389_21390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KM389_21395	COG1121	(ABC) transporter
KM389_21400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_21430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM389_21435	COG2384	SAM-dependent methyltransferase
KM389_21440	COG2010	Cytochrome c
KM389_21445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KM389_21450	COG0358	DNA primase activity
KM389_21460	COG0517	IMP dehydrogenase activity
KM389_21475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KM389_21480	COG0295	cytidine deaminase activity
KM389_21485	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KM389_21495	COG1480	7TM receptor with intracellular HD hydrolase
KM389_21500	COG1702	phosphate starvation-inducible protein PhoH
KM389_21515	COG1610	YqeY-like protein
KM389_21520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KM389_21525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KM389_21530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KM389_21560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KM389_21565	COG1733	regulation of RNA biosynthetic process
KM389_21590	COG1466	dna polymerase III delta subunit
KM389_21600	COG2333	competence protein COMEC
KM389_21600	COG0658	competence protein
KM389_21605	COG2131	deaminase
KM389_21610	COG1555	photosystem II stabilization
KM389_21610	COG1596	polysaccharide export
KM389_21615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KM389_21620	COG2226	methyltransferase
KM389_21625	COG0799	negative regulation of ribosome biogenesis
KM389_21630	COG1713	HD superfamily hydrolase involved in NAD metabolism
KM389_21640	COG1534	Rna-binding protein
KM389_21650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KM389_21655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KM389_21680	COG1595	DNA-templated transcription, initiation
KM389_21690	COG0778	Nitroreductase
KM389_21695	COG2357	RelA SpoT domain protein
KM389_21705	COG1785	Belongs to the alkaline phosphatase family
KM389_21715	COG2267	carboxylic ester hydrolase activity
KM389_21750	COG1404	Belongs to the peptidase S8 family
KM389_21755	COG3186	Phenylalanine-4-hydroxylase
KM389_21770	COG2259	Doxx family
KM389_21810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_21820	COG1012	belongs to the aldehyde dehydrogenase family
KM389_21820	COG1454	alcohol dehydrogenase
KM389_21825	COG0626	cystathionine gamma-synthase activity
KM389_21830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KM389_21855	COG0768	penicillin binding
KM389_21870	COG0826	peptidase U32
KM389_21875	COG0826	peptidase U32
KM389_21880	COG4122	O-methyltransferase activity
KM389_21885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KM389_21905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KM389_21915	COG0628	permease
KM389_21935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KM389_21945	COG0482	sulfurtransferase activity
KM389_21950	COG1104	cysteine desulfurase activity
KM389_21955	COG1959	2 iron, 2 sulfur cluster binding
KM389_21960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KM389_21970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KM389_21995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KM389_22005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KM389_22005	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KM389_22010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KM389_22015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM389_22015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KM389_22025	COG2244	polysaccharide biosynthetic process
KM389_22030	COG2323	membrane
KM389_22040	COG1862	Preprotein translocase
KM389_22070	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KM389_22080	COG0697	spore germination
KM389_22085	COG0697	spore germination
KM389_22090	COG0640	Transcriptional regulator
KM389_22115	COG0157	Belongs to the NadC ModD family
KM389_22120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KM389_22125	COG1104	cysteine desulfurase activity
KM389_22130	COG1827	regulation of RNA biosynthetic process
KM389_22135	COG2258	MOSC domain
KM389_22140	COG0077	Prephenate dehydratase
KM389_22145	COG0577	efflux transmembrane transporter activity
KM389_22150	COG0577	efflux transmembrane transporter activity
KM389_22155	COG1136	(ABC) transporter
KM389_22165	COG0745	RESPONSE REGULATOR receiver
KM389_22170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KM389_22175	COG3290	protein histidine kinase activity
KM389_22185	COG2868	ribosomal protein
KM389_22195	COG1530	ribonuclease E activity
KM389_22200	COG1994	Peptidase M50
KM389_22205	COG0739	heme binding
KM389_22210	COG2894	cell division
KM389_22230	COG1077	Cell shape determining protein MreB Mrl
KM389_22250	COG0285	dihydrofolate synthase activity
KM389_22255	COG0525	valine-tRNA ligase activity
KM389_22265	COG1388	LysM domain
KM389_22275	COG0113	porphobilinogen synthase activity
KM389_22280	COG1587	Uroporphyrinogen-III synthase
KM389_22290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KM389_22300	COG1846	Transcriptional regulator
KM389_22305	COG1764	response to oxidative stress
KM389_22320	COG0470	DNA polymerase III
KM389_22320	COG1067	ATP-dependent peptidase activity
KM389_22365	COG0622	Phosphoesterase
KM389_22380	COG5401	PFAM Sporulation and spore germination
KM389_22400	COG1309	transcriptional regulator
KM389_22415	COG2197	response regulator
KM389_22420	COG2233	PERMEase
KM389_22430	COG0402	S-adenosylhomocysteine deaminase activity
KM389_22435	COG0402	S-adenosylhomocysteine deaminase activity
KM389_22445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KM389_22455	COG0444	Belongs to the ABC transporter superfamily
KM389_22460	COG4608	Belongs to the ABC transporter superfamily
KM389_22465	COG3275	phosphorelay sensor kinase activity
KM389_22470	COG3279	Response regulator of the LytR AlgR family
KM389_22485	COG1983	PspC domain protein
KM389_22490	COG1396	sequence-specific DNA binding
KM389_22495	COG0697	spore germination
KM389_22505	COG1959	2 iron, 2 sulfur cluster binding
KM389_22510	COG1668	transmembrane transport
KM389_22515	COG4152	abc transporter atp-binding protein
KM389_22520	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KM389_22530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KM389_22535	COG1876	peptidase activity
KM389_22540	COG0824	Thioesterase
KM389_22545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KM389_22550	COG1053	succinate dehydrogenase
KM389_22555	COG2009	succinate dehydrogenase
KM389_22560	COG1719	4-vinyl reductase, 4VR
KM389_22570	COG3118	belongs to the thioredoxin family
KM389_22575	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KM389_22580	COG2086	electron transfer activity
KM389_22585	COG1024	Enoyl-CoA hydratase
KM389_22590	COG1309	transcriptional regulator
KM389_22595	COG0318	PFAM AMP-dependent synthetase and ligase
KM389_22615	COG2318	DinB family
KM389_22645	COG1131	(ABC) transporter
KM389_22650	COG2205	protein histidine kinase activity
KM389_22655	COG0745	RESPONSE REGULATOR receiver
KM389_22665	COG4895	conserved protein (DUF2196)
KM389_22670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KM389_22685	COG4509	Sortase family
KM389_22690	COG1120	ATPase activity
KM389_22705	COG5386	Cell surface protein
KM389_22715	COG5386	Cell surface protein
KM389_22720	COG1114	Component of the transport system for branched-chain amino acids
KM389_22725	COG1187	pseudouridine synthase activity
KM389_22735	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KM389_22735	COG1796	DNA polymerase
KM389_22740	COG1286	toxin biosynthetic process
KM389_22785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KM389_22795	COG1418	mRNA catabolic process
KM389_22820	COG2814	Major facilitator Superfamily
KM389_22825	COG1566	PFAM secretion protein HlyD family protein
KM389_22830	COG1309	transcriptional regulator
KM389_22835	COG1363	Peptidase, m42
KM389_22860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KM389_22870	COG1484	DNA-dependent DNA replication
KM389_22875	COG3611	Membrane attachment protein
KM389_22885	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM389_22890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM389_22895	COG0237	dephospho-CoA kinase activity
KM389_22900	COG1971	Probably functions as a manganese efflux pump
KM389_22910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM389_22910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KM389_22915	COG5002	protein histidine kinase activity
KM389_22920	COG0745	RESPONSE REGULATOR receiver
KM389_22940	COG0538	isocitrate dehydrogenase activity
KM389_22945	COG0372	Belongs to the citrate synthase family
KM389_22955	COG0628	permease
KM389_22960	COG3030	protein affecting phage T7 exclusion by the F plasmid
KM389_22985	COG1725	Transcriptional regulator
KM389_22990	COG0281	malic enzyme
KM389_22995	COG0587	DNA-directed DNA polymerase activity
KM389_23010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KM389_23030	COG4109	DRTGG domain
KM389_23045	COG0006	proline dipeptidase activity
KM389_23080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_23085	COG0662	Cupin 2, conserved barrel domain protein
KM389_23095	COG1476	TRANSCRIPTIONal
KM389_23110	COG1028	Short-chain dehydrogenase reductase Sdr
KM389_23115	COG0589	response to stress
KM389_23155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_23175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KM389_23180	COG0827	DNA restriction-modification system
KM389_23185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KM389_23190	COG3874	Sporulation protein YtfJ
KM389_23205	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KM389_23215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM389_23230	COG1104	cysteine desulfurase activity
KM389_23240	COG0583	DNA-binding transcription factor activity
KM389_23245	COG0697	spore germination
KM389_23255	COG1956	GAF domain-containing protein
KM389_23260	COG0626	cystathionine gamma-synthase activity
KM389_23290	COG1595	DNA-templated transcription, initiation
KM389_23300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KM389_23305	COG0454	-acetyltransferase
KM389_23310	COG0517	IMP dehydrogenase activity
KM389_23315	COG0123	including yeast histone deacetylase and acetoin utilization protein
KM389_23325	COG0745	RESPONSE REGULATOR receiver
KM389_23330	COG5002	protein histidine kinase activity
KM389_23335	COG0666	response to abiotic stimulus
KM389_23370	COG1609	Transcriptional regulator
KM389_23375	COG4851	CamS sex pheromone cAM373 precursor
KM389_23380	COG3118	belongs to the thioredoxin family
KM389_23390	COG2309	aminopeptidase activity
KM389_23410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_23425	COG1674	ftsk spoiiie
KM389_23435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KM389_23440	COG4848	Belongs to the UPF0354 family
KM389_23445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM389_23450	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KM389_23455	COG1363	Peptidase, m42
KM389_23465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_23480	COG0510	thiamine kinase activity
KM389_23485	COG1523	belongs to the glycosyl hydrolase 13 family
KM389_23500	COG1349	DNA-binding transcription factor activity
KM389_23505	COG1187	pseudouridine synthase activity
KM389_23510	COG2244	polysaccharide biosynthetic process
KM389_23515	COG2081	HI0933 family
KM389_23520	COG2814	Major facilitator Superfamily
KM389_23530	COG3832	glyoxalase III activity
KM389_23550	COG1329	Transcriptional regulator
KM389_23560	COG4975	Glucose uptake
KM389_23575	COG0314	molybdopterin synthase activity
KM389_23580	COG1763	Mo-molybdopterin cofactor biosynthetic process
KM389_23585	COG0303	'Molybdopterin
KM389_23595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KM389_23620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KM389_23630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KM389_23670	COG2814	Major facilitator Superfamily
KM389_23675	COG0475	glutathione-regulated potassium exporter activity
KM389_23680	COG0490	domain, Protein
KM389_23685	COG0582	viral genome integration into host DNA
KM389_23695	COG1136	(ABC) transporter
KM389_23715	COG1242	4 iron, 4 sulfur cluster binding
KM389_23720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KM389_23725	COG1131	(ABC) transporter
KM389_23735	COG1794	racemase activity, acting on amino acids and derivatives
KM389_23755	COG2267	carboxylic ester hydrolase activity
KM389_23760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KM389_23765	COG0671	phosphoesterase, PA-phosphatase related
KM389_23770	COG0438	transferase activity, transferring glycosyl groups
KM389_23780	COG0521	Mo-molybdopterin cofactor biosynthetic process
KM389_23835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KM389_23840	COG5002	protein histidine kinase activity
KM389_23845	COG4191	Histidine kinase
KM389_23850	COG2267	carboxylic ester hydrolase activity
KM389_23870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KM389_23875	COG1116	anion transmembrane transporter activity
KM389_23880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KM389_23905	COG0494	nUDIX hydrolase
KM389_23935	COG0288	reversible hydration of carbon dioxide
KM389_23940	COG1271	oxidase subunit
KM389_23945	COG1294	oxidase, subunit
KM389_23965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_23990	COG1842	Phage shock protein A
KM389_24020	COG5002	protein histidine kinase activity
KM389_24025	COG0745	RESPONSE REGULATOR receiver
KM389_24055	COG1597	lipid kinase activity
KM389_24090	COG0586	Pfam SNARE associated Golgi protein
KM389_24100	COG0577	efflux transmembrane transporter activity
KM389_24105	COG1136	(ABC) transporter
KM389_24110	COG2207	Transcriptional regulator
KM389_24110	COG3708	Transcriptional regulator
KM389_24115	COG0745	RESPONSE REGULATOR receiver
KM389_24120	COG2205	protein histidine kinase activity
KM389_24125	COG0577	efflux transmembrane transporter activity
KM389_24135	COG0577	efflux transmembrane transporter activity
KM389_24140	COG1136	(ABC) transporter
KM389_24160	COG2188	Transcriptional regulator
KM389_24180	COG3964	amidohydrolase
KM389_24210	COG4948	Mandelate Racemase Muconate Lactonizing
KM389_24220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KM389_24225	COG0596	Alpha beta hydrolase
KM389_24230	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KM389_24235	COG1169	isochorismate synthase
KM389_24240	COG1575	Belongs to the MenA family. Type 1 subfamily
KM389_24245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KM389_24265	COG0058	SHG alpha-glucan phosphorylase activity
KM389_24270	COG0297	glycogen (starch) synthase activity
KM389_24275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KM389_24395	COG0544	peptidyl-prolyl cis-trans isomerase activity
KM389_24430	COG1285	pathogenesis
KM389_24435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM389_24445	COG0166	Belongs to the GPI family
KM389_24450	COG2155	Conserved Protein
KM389_24455	COG1098	S1 RNA binding domain
KM389_24460	COG0436	Aminotransferase
KM389_24465	COG1522	sequence-specific DNA binding
KM389_24470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KM389_24475	COG2267	carboxylic ester hydrolase activity
KM389_24485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KM389_24505	COG5018	Exonuclease
KM389_24510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM389_24530	COG2050	protein possibly involved in aromatic compounds catabolism
KM389_24540	COG1268	BioY protein
KM389_24550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM389_24555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KM389_24570	COG3584	3D domain protein
KM389_24585	COG1252	NADH dehydrogenase
KM389_24600	COG3708	Transcriptional regulator
KM389_24615	COG1683	Conserved Protein
KM389_24635	COG0316	Belongs to the HesB IscA family
KM389_24650	COG1252	NADH dehydrogenase
KM389_24665	COG0390	transport system, permease component
KM389_24670	COG2824	Alkylphosphonate utilization operon protein PhnA
KM389_24710	COG4837	Protein of unknown function (DUF1462)
KM389_24715	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KM389_24725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KM389_24730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KM389_24740	COG2249	NAD(P)H dehydrogenase (quinone) activity
KM389_24745	COG0647	UMP catabolic process
KM389_24755	COG2445	Protein of unknown function DUF86
KM389_24760	COG1494	fructose-1,6-bisphosphatase
KM389_24775	COG4470	Protein conserved in bacteria
KM389_24785	COG0789	Transcriptional regulator
KM389_24790	COG4377	Putative membrane peptidase family (DUF2324)
KM389_24815	COG0739	heme binding
KM389_24825	COG3377	Domain of unknown function (DUF1805)
KM389_24830	COG0737	Belongs to the 5'-nucleotidase family
KM389_24835	COG1695	Transcriptional regulator
KM389_24845	COG0719	Fe-S assembly protein
KM389_24850	COG0822	iron-sulfur transferase activity
KM389_24855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KM389_24860	COG0719	Fe-S assembly protein
KM389_24865	COG0396	ATPase activity
KM389_24870	COG1464	Belongs to the NlpA lipoprotein family
KM389_24875	COG1464	Belongs to the NlpA lipoprotein family
KM389_24880	COG2011	ABC-type metal ion transport system permease component
KM389_24885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KM389_24895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KM389_24900	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KM389_24910	COG1393	Belongs to the ArsC family
KM389_24955	COG0039	L-malate dehydrogenase activity
KM389_24975	COG1309	transcriptional regulator
KM389_24980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KM389_24985	COG1960	acyl-CoA dehydrogenase activity
KM389_24990	COG0183	Belongs to the thiolase family
KM389_24995	COG1024	Enoyl-CoA hydratase
KM389_24995	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM389_25005	COG1686	Belongs to the peptidase S11 family
KM389_25020	COG0011	TIGRFAM Protein of
KM389_25025	COG0840	transmembrane signaling receptor activity
KM389_25045	COG2814	Major facilitator Superfamily
KM389_25050	COG0531	amino acid
KM389_25060	COG0706	membrane insertase activity
KM389_25070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KM389_25105	COG0586	Pfam SNARE associated Golgi protein
KM389_25115	COG1376	ErfK ybiS ycfS ynhG family protein
KM389_25120	COG0745	RESPONSE REGULATOR receiver
KM389_25125	COG5002	protein histidine kinase activity
KM389_25150	COG2151	metal-sulfur cluster biosynthetic enzyme
KM389_25155	COG3227	Zinc metalloprotease (Elastase)
KM389_25160	COG1741	Belongs to the pirin family
KM389_25175	COG0475	glutathione-regulated potassium exporter activity
KM389_25180	COG0490	domain, Protein
KM389_25185	COG1115	amino acid carrier protein
KM389_25190	COG0783	Belongs to the Dps family
KM389_25205	COG1611	Belongs to the LOG family
KM389_25225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_25230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_25235	COG1115	amino acid carrier protein
KM389_25240	COG1115	amino acid carrier protein
KM389_25245	COG2910	NAD(P)H-binding
KM389_25260	COG0656	L-ascorbic acid biosynthetic process
KM389_25265	COG2814	Major facilitator Superfamily
KM389_25270	COG1733	regulation of RNA biosynthetic process
KM389_25280	COG1252	NADH dehydrogenase
KM389_25285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KM389_25290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KM389_25300	COG3290	protein histidine kinase activity
KM389_25300	COG0840	transmembrane signaling receptor activity
KM389_25310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM389_25315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KM389_25330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KM389_25385	COG0557	exoribonuclease II activity
KM389_25390	COG1647	Serine aminopeptidase, S33
KM389_25395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KM389_25400	COG1346	cytolysis
KM389_25500	COG4695	Portal protein
KM389_25525	COG4974	Belongs to the 'phage' integrase family
KM389_25535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KM389_25540	COG0149	triose-phosphate isomerase activity
KM389_25550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KM389_25565	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KM389_25590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KM389_25605	COG2323	membrane
KM389_25610	COG0740	serine-type endopeptidase activity
KM389_25615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KM389_25625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KM389_25635	COG1051	belongs to the nudix hydrolase family
KM389_25645	COG0492	ferredoxin-NADP+ reductase activity
KM389_25650	COG0457	Tetratricopeptide repeat
KM389_25655	COG0110	maltose O-acetyltransferase activity
KM389_25675	COG1950	PFAM Membrane protein of
KM389_25685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KM389_25690	COG0556	nucleotide-excision repair
KM389_25710	COG0789	Transcriptional regulator
KM389_25735	COG2855	membrane
KM389_25740	COG0583	DNA-binding transcription factor activity
KM389_25750	COG0655	NAD(P)H dehydrogenase (quinone) activity
KM389_25755	COG0488	(ABC) transporter
KM389_25765	COG1132	(ABC) transporter
KM389_25770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM389_25775	COG0793	Belongs to the peptidase S41A family
KM389_25775	COG3409	Peptidoglycan-binding domain 1 protein
KM389_25780	COG2177	Part of the ABC transporter FtsEX involved in
KM389_25785	COG2884	Cell division ATP-binding protein ftsE
KM389_25800	COG0653	protein targeting
KM389_25805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KM389_25810	COG1278	Cold shock
KM389_25815	COG1040	competence protein
KM389_25820	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KM389_25825	COG0791	NLP P60 protein
KM389_25825	COG1388	LysM domain
KM389_25830	COG1733	regulation of RNA biosynthetic process
KM389_25835	COG1307	EDD domain protein, DegV family
KM389_25840	COG1739	Uncharacterized protein family UPF0029
KM389_25845	COG1316	TRANSCRIPTIONal
KM389_25850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM389_25855	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KM389_25860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KM389_25870	COG3933	PFAM sigma-54 factor interaction domain-containing protein
KM389_25870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KM389_25885	COG3394	polysaccharide catabolic process
KM389_25890	COG1486	melibiose metabolic process
KM389_25895	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM389_25900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM389_25910	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KM389_25915	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KM389_25920	COG1447	Phosphotransferase system cellobiose-specific component IIA
KM389_25930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KM389_25935	COG1301	dicarboxylic acid transport
KM389_25945	COG0346	lactoylglutathione lyase activity
KM389_25950	COG1511	domain protein
KM389_25955	COG0583	DNA-binding transcription factor activity
KM389_25960	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KM389_25975	COG1271	oxidase subunit
KM389_25980	COG1294	oxidase, subunit
KM389_25985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KM389_26005	COG2389	metal-binding protein
KM389_26015	COG1368	sulfuric ester hydrolase activity
KM389_26030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KM389_26040	COG1215	transferase activity, transferring glycosyl groups
KM389_26045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM389_26050	COG3584	3D domain protein
KM389_26050	COG1388	LysM domain
KM389_26075	COG4715	Zinc finger, swim domain protein
KM389_26080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KM389_26120	COG0577	efflux transmembrane transporter activity
KM389_26125	COG1136	(ABC) transporter
KM389_26160	COG5002	protein histidine kinase activity
KM389_26165	COG0745	RESPONSE REGULATOR receiver
KM389_26170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM389_26185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KM389_26190	COG1134	teichoic acid transport
KM389_26195	COG1682	transport, permease protein
KM389_26200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KM389_26245	COG1609	Transcriptional regulator
KM389_26260	COG0739	heme binding
KM389_26280	COG2385	sporulation resulting in formation of a cellular spore
KM389_26295	COG4836	Membrane
KM389_26300	COG1007	ATP synthesis coupled electron transport
KM389_26305	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM389_26310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KM389_26320	COG0839	Belongs to the complex I subunit 6 family
KM389_26335	COG0649	NAD binding
KM389_26340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KM389_26355	COG3300	MHYT domain
KM389_26355	COG5001	Diguanylate cyclase
KM389_26405	COG0356	it plays a direct role in the translocation of protons across the membrane
KM389_26440	COG0698	ribose 5-phosphate isomerase
KM389_26450	COG2190	(PTS) system
KM389_26455	COG2259	Doxx family
KM389_26460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KM389_26475	COG0009	L-threonylcarbamoyladenylate synthase
KM389_26490	COG2890	protein-(glutamine-N5) methyltransferase activity
KM389_26510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KM389_26515	COG1494	fructose-1,6-bisphosphatase
KM389_26535	COG4821	SIS domain
KM389_26545	COG3343	RNA polymerase activity
KM389_26555	COG1960	acyl-CoA dehydrogenase activity
KM389_26560	COG1960	acyl-CoA dehydrogenase activity
KM389_26565	COG1250	3-hydroxyacyl-CoA dehydrogenase
KM389_26570	COG0183	Belongs to the thiolase family
KM389_26575	COG0247	lactate metabolic process
KM389_26575	COG2181	nitrate reductase activity
KM389_26580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KM389_26590	COG3300	MHYT domain
KM389_26590	COG5001	Diguanylate cyclase
KM389_26610	COG2197	response regulator
KM389_26615	COG4585	Histidine kinase
KM389_26620	COG0842	Transport permease protein
KM389_26625	COG1131	(ABC) transporter
KM389_26630	COG0024	Methionine aminopeptidase
KM389_26640	COG2234	aminopeptidase activity
KM389_26660	COG1595	DNA-templated transcription, initiation
KM389_26665	COG0018	arginyl-trna synthetase
KM389_26670	COG4506	Protein conserved in bacteria
KM389_26675	COG1619	proteins homologs of microcin C7 resistance protein MccF
KM389_26690	COG0010	Belongs to the arginase family
KM389_26700	COG2814	Major facilitator Superfamily
KM389_26705	COG0789	Transcriptional regulator
KM389_26710	COG0584	glycerophosphoryl diester phosphodiesterase
KM389_26715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KM389_26725	COG1994	Peptidase M50
KM389_26735	COG1078	dGTPase activity
KM389_26740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KM389_26745	COG1120	ATPase activity
KM389_26750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KM389_26775	COG0095	Lipoate-protein ligase
KM389_26780	COG0280	phosphate acetyltransferase
KM389_26795	COG3773	Cell wall hydrolase
KM389_26805	COG2363	Small membrane protein
KM389_26815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KM389_26820	COG2233	PERMEase
KM389_26825	COG0561	phosphatase activity
KM389_26830	COG2814	Major facilitator Superfamily
KM389_26840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KM389_26845	COG1131	(ABC) transporter
KM389_26850	COG2755	lipolytic protein G-D-S-L family
KM389_26855	COG1609	Transcriptional regulator
KM389_26865	COG0460	homoserine dehydrogenase
KM389_26875	COG2873	o-acetylhomoserine
KM389_26885	COG1011	Hydrolase
KM389_26890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KM389_26900	COG2197	response regulator
KM389_26910	COG0351	phosphomethylpyrimidine kinase
KM389_26915	COG3706	GGDEF domain
KM389_26920	COG2879	small protein
KM389_26925	COG1966	Carbon starvation protein
KM389_26930	COG3279	Response regulator of the LytR AlgR family
KM389_26935	COG0477	Major facilitator Superfamily
KM389_26960	COG0840	transmembrane signaling receptor activity
KM389_26970	COG1607	acyl-coa hydrolase
KM389_26985	COG0488	(ABC) transporter
KM389_27005	COG0463	Glycosyl transferase, family 2
KM389_27010	COG1309	transcriptional regulator
KM389_27015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KM389_27020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM389_27020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KM389_27025	COG0628	permease
KM389_27040	COG3279	Response regulator of the LytR AlgR family
KM389_27045	COG3275	phosphorelay sensor kinase activity
KM389_27050	COG2814	Major facilitator Superfamily
KM389_27055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KM389_27060	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KM389_27065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KM389_27085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KM389_27090	COG1272	protein, Hemolysin III
KM389_27110	COG0516	GMP reductase activity
KM389_27115	COG1164	Oligoendopeptidase f
KM389_27135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KM389_27140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KM389_27145	COG4853	Protein conserved in bacteria
KM389_27150	COG4863	YycH protein
KM389_27155	COG5002	protein histidine kinase activity
KM389_27160	COG0745	RESPONSE REGULATOR receiver
KM389_27190	COG0305	Participates in initiation and elongation during chromosome replication
KM389_27200	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KM389_27205	COG4241	membrane
KM389_27215	COG0629	single-stranded DNA binding
KM389_27225	COG0012	GTP binding
KM389_27230	COG4481	Protein conserved in bacteria
KM389_27235	COG0668	transmembrane transport
KM389_27245	COG1475	DNA binding
KM389_27250	COG1192	Involved in chromosome partitioning
KM389_27275	COG1847	R3H domain protein
KM389_27280	COG0706	membrane insertase activity
KM389_27290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KM389_27340	COG3344	reverse transcriptase
KM389_27420	COG3344	reverse transcriptase
KM389_27610	COG4962	Type ii secretion system protein e
KM389_27745	COG2311	Membrane
KM389_27765	COG4196	transglutaminase domain protein
KM389_27770	COG0671	phosphoesterase, PA-phosphatase related
KM389_27785	COG1215	transferase activity, transferring glycosyl groups
KM389_27790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KM389_27955	COG2002	toxin-antitoxin pair type II binding
KM389_27965	COG4974	Belongs to the 'phage' integrase family
KM389_28020	COG3443	Belongs to the bacterial solute-binding protein 9 family
KM389_28030	COG4974	Belongs to the 'phage' integrase family
KM389_28055	COG0457	Tetratricopeptide repeat
KM389_28260	COG0741	lytic transglycosylase activity
KM389_28260	COG0791	NLP P60 protein
KM389_28325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KM389_28385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KM389_28395	COG4166	transmembrane transport
KM389_28460	COG0681	Belongs to the peptidase S26 family
KM389_28535	COG1309	transcriptional regulator
KM389_28540	COG1683	Conserved Protein
KM389_28580	COG1192	Involved in chromosome partitioning