locus-tag class description KD35_00040 ENOG4105DAA L-lactate KD35_00050 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) KD35_00060 ENOG4105E0M Sulfatase KD35_00085 ENOG4107R8N Glycosyl transferase, family 2 KD35_00095 ENOG4105C94 Transporter KD35_00100 ENOG41069ER domain protein KD35_00125 ENOG4105KBK Zinc finger, swim domain protein KD35_00130 ENOG4105C0D helicase KD35_00160 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_00170 ENOG4107RBB ABC transporter, permease KD35_00175 ENOG4105C19 ABC transporter KD35_00195 ENOG4105CXY transporter KD35_00210 ENOG4105BZU Histidine kinase KD35_00215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_00220 ENOG4105CMR udp-glucose 4-epimerase KD35_00240 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KD35_00245 ENOG4105EY8 ABC transporter KD35_00300 ENOG4105MT0 Sporulation transcriptional regulator spoiiid KD35_00315 ENOG4105FRN stage II sporulation protein KD35_00330 ENOG4105DY9 regulatoR KD35_00335 ENOG4108IUW ABC transporter KD35_00355 ENOG4106778 Protein of unknown function (DUF1146) KD35_00360 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KD35_00365 ENOG4105C8S subunit m KD35_00370 ENOG4105D65 subunit l KD35_00395 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) KD35_00400 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain KD35_00410 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain KD35_00415 ENOG4105BZU Histidine kinase KD35_00465 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) KD35_00470 ENOG41062M3 atp synthase KD35_00500 ENOG4108YZG isomerase KD35_00515 ENOG4108VGI doxx family KD35_00520 ENOG4107XC4 flavin reductase domain protein, FMN-binding KD35_00535 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KD35_00545 ENOG4108ZXQ stage ii sporulation protein r KD35_00550 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) KD35_00555 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) KD35_00570 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) KD35_00575 ENOG4105CBT Fructose-1,6-bisphosphatase KD35_00580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) KD35_00615 ENOG4105C1G acyl-Coa dehydrogenase KD35_00620 ENOG4105C1G acyl-Coa dehydrogenase KD35_00625 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase KD35_00635 ENOG4105DF6 Fe-S oxidoreductase KD35_00650 ENOG4105BZU Histidine kinase KD35_00670 ENOG4105BZU Histidine kinase KD35_00675 ENOG4105KCT ABC transporter KD35_00680 ENOG4108M15 ABC transporter KD35_00685 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) KD35_00705 ENOG4105IIU Aminopeptidase KD35_00725 ENOG4105EMN RNA polymerase sigma factor KD35_00735 ENOG410684U Domain of unknown function (DUF1934) KD35_00760 ENOG4105CYW agmatinase KD35_00770 ENOG4105DXB Major Facilitator superfamily KD35_00775 ENOG4107SWG transcriptional regulator MERR family KD35_00780 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KD35_00785 ENOG4105BZ4 penicillin-binding protein KD35_00790 ENOG4108XFG YwhD family KD35_00795 ENOG4108Z4T Peptidase M50 KD35_00800 ENOG41069HH 4-oxalocrotonate tautomerase KD35_00805 ENOG4105DCI Phosphohydrolase KD35_00810 ENOG4108MES Periplasmic binding protein KD35_00815 ENOG4105E0A ABC, transporter KD35_00820 ENOG4105EHG Permease protein KD35_00825 ENOG4105DQ5 transport system permease protein KD35_00830 ENOG4105DQ5 transport system permease protein KD35_00840 ENOG4108VCI transcription factor, rsfa family KD35_00855 ENOG4108IJ2 phosphate acetyltransferase KD35_00870 ENOG4108VKI Cell wall hydrolase KD35_00890 ENOG4107SVH Potassium channel protein KD35_00900 ENOG410667J hydrolase KD35_00905 ENOG4105VCH membrane KD35_00915 ENOG4108TU7 Inherit from COG: (ABC) transporter KD35_00920 ENOG4105CJ1 ABC, transporter KD35_00925 ENOG41090WU lipolytic protein G-D-S-L family KD35_00940 ENOG4105D6E homoserine dehydrogenase KD35_00965 ENOG4108Y4K DNA-binding transcriptional activator KD35_00975 ENOG4105WH1 Two component transcriptional regulator luxr family KD35_00985 ENOG4105DWF phosphomethylpyrimidine kinase KD35_00990 ENOG4105BZU Histidine kinase KD35_00995 ENOG4105VCD cytoplasmic protein KD35_01000 ENOG4105D22 carbon starvation protein KD35_01005 ENOG4105DY9 regulatoR KD35_01010 ENOG41079KZ Major Facilitator Superfamily KD35_01030 ENOG4105EN6 Membrane KD35_01035 ENOG4106YBV Methyl-accepting chemotaxis KD35_01045 ENOG4108S4H thioesterase Superfamily protein KD35_01055 ENOG4105JEU Glycosyl transferase, family 2 KD35_01060 ENOG4105C5H ABC transporter KD35_01085 ENOG4105CKK Glycosyl transferase, family 2 KD35_01090 ENOG41067SE Tetr family transcriptional regulator KD35_01100 ENOG4105E0X reductase KD35_01105 ENOG4106F5Q Membrane KD35_01120 ENOG4105DY9 regulatoR KD35_01125 ENOG4108HRK Histidine kinase KD35_01130 ENOG4107RGD Major Facilitator superfamily KD35_01145 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KD35_01155 ENOG4105IW1 AmiS UreI transporter KD35_01165 ENOG4105CMR udp-glucose 4-epimerase KD35_01170 ENOG4108UT2 hemolysin iii KD35_01180 ENOG4105C1J atp-dependent rna helicase KD35_01195 ENOG4105DPN Oligoendopeptidase f KD35_01215 ENOG4105C0H protease KD35_01220 ENOG4105Q2H domain protein KD35_01235 ENOG4105BZU Histidine kinase KD35_01240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_01270 ENOG4105CDU Replicative dna helicase KD35_01280 ENOG4105BZR domain protein KD35_01285 ENOG4108XMW Membrane KD35_01295 ENOG4108UUM single-stranded DNA-binding protein KD35_01305 ENOG4105C3G gtp-binding protein KD35_01310 ENOG4105VDK protein, conserved in bacteria KD35_01315 ENOG4105D8X mechanosensitive ion channel KD35_01320 ENOG4108ZDA Sporulation protein YyaC KD35_01325 ENOG4105FA0 parb-like partition protein KD35_01330 ENOG4107QJE Chromosome Partitioning Protein KD35_01350 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) KD35_01360 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins KD35_01380 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KD35_01385 ENOG410848D S4 domain protein YaaA KD35_01400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KD35_01435 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) KD35_01470 ENOG4105ZMH deoxynucleoside kinase KD35_01480 ENOG4105GTG Isochorismatase KD35_01490 ENOG4108Z6B deaminase KD35_01495 ENOG4105C6E dna polymerase iii KD35_01515 ENOG41067KS pro-sigma K processing KD35_01550 ENOG4105CXN decarboxylase KD35_01560 ENOG4105FA2 dna polymerase iii KD35_01565 ENOG4105MA4 psp1 domain protein KD35_01575 ENOG41060K3 Methyltransferase KD35_01585 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) KD35_01590 ENOG4105KRN Transcriptional regulator, abrb family KD35_01600 ENOG4105F8V Hydrolase, tatD family KD35_01605 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) KD35_01615 ENOG4105XFA sporulation peptidase YabG KD35_01620 ENOG4105W42 Veg protein KD35_01635 ENOG4105DFT pur operon repressor KD35_01640 ENOG4105KME endoribonuclease L-psp KD35_01655 ENOG4105C5T Phosphoribosyl pyrophosphate synthase KD35_01660 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) KD35_01670 ENOG4108JA2 transcriptioN-repair coupling factor KD35_01675 ENOG4108M14 stage v sporulation protein t KD35_01685 ENOG4108IY2 MazG family KD35_01690 ENOG41082I2 s4 domain protein KD35_01695 ENOG4105VYY sporulation protein yabp KD35_01710 ENOG41060GV RNA binding s1 domain protein KD35_01730 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) KD35_01735 ENOG4108UGV hypoxanthine phosphoribosyltransferase KD35_01740 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) KD35_01755 ENOG4105C6T cysteine synthase KD35_01760 ENOG4105CRQ synthase (Component I) KD35_01765 ENOG4105DDQ anthranilate synthase KD35_01770 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 KD35_01775 ENOG4105EEI dihydropteroate synthase KD35_01780 ENOG4105KRF dihydroneopterin aldolase KD35_01785 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase KD35_01795 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) KD35_01825 ENOG4108Z0C Uvrb UvrC protein KD35_01840 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) KD35_01850 ENOG4105CTP PilT protein domain protein KD35_01870 ENOG4105D7W serine acetyltransferase KD35_01885 ENOG4105C2N RNA methyltransferase TrmH family group 3 KD35_01890 ENOG4105M0M Tetracycline resistance protein KD35_01895 ENOG4105QIV RNA polymerase KD35_01910 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) KD35_01935 ENOG4107Y49 methyltransferase KD35_01945 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) KD35_01950 ENOG4105XPM ribosomal protein KD35_02055 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) KD35_02080 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KD35_02090 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KD35_02100 ENOG41067V7 50S ribosomal protein L36 KD35_02130 ENOG4108JJB ABC transporter KD35_02135 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KD35_02140 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KD35_02165 ENOG4105D1F ATP-binding protein KD35_02180 ENOG4108NMV polysaccharide deacetylase KD35_02265 ENOG4105C8B TIGR00159 family KD35_02270 ENOG4107U5W ybbr family KD35_02285 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) KD35_02290 ENOG4108VQT Alpha beta hydrolase fold protein KD35_02310 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) KD35_02315 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein KD35_02350 ENOG4108PSK reductase KD35_02355 ENOG4108UMI ABC transporter, permease KD35_02360 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KD35_02365 ENOG4105D01 (LipO)protein KD35_02370 ENOG4105EE1 crotonyl-CoA reductase KD35_02380 ENOG4105IQ5 FAD linked oxidase domain protein KD35_02395 ENOG4105C2C drug resistance transporter, Bcr CflA KD35_02410 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KD35_02415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KD35_02420 ENOG4105C3U ABC transporter KD35_02425 ENOG4108JQ7 (ABC) transporter KD35_02455 ENOG4108J59 Extracellular solute-binding protein, family 5 KD35_02460 ENOG4108J59 Extracellular solute-binding protein, family 5 KD35_02470 ENOG4105II7 pyrroline-5-carboxylate reductase KD35_02480 ENOG4107XDY Nicotinamide Mononucleotide Transporter KD35_02490 ENOG4105E0C molybdate abc transporter KD35_02495 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KD35_02500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KD35_02505 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family KD35_02520 ENOG4105EGI Transcriptional regulator KD35_02535 ENOG4105F6E Acyl-transferase KD35_02555 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KD35_02570 ENOG4108RE7 deoxyribonuclease KD35_02575 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) KD35_02600 ENOG4105C5H ABC transporter KD35_02615 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein KD35_02625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KD35_02630 ENOG4105C3U ABC transporter KD35_02635 ENOG4108JQ7 (ABC) transporter KD35_02675 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase KD35_02680 ENOG4105ERH Fumarylacetoacetate hydrolase KD35_02690 ENOG4108SC4 )-transporter KD35_02695 ENOG4105CPF Cell wall formation (By similarity) KD35_02700 ENOG4105CPF Cell wall formation (By similarity) KD35_02705 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KD35_02720 ENOG4107ZXI Rhomboid family KD35_02730 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein KD35_02735 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KD35_02745 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) KD35_02845 ENOG4105K8N protein family UPF0079, ATPase KD35_02850 ENOG41072GX Peptidase M22 Glycoprotease KD35_02855 ENOG410801F ribosomal-protein-alanine acetyltransferase KD35_02860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) KD35_02865 ENOG4105C5H ABC transporter KD35_02880 ENOG4108TYN CAAX amino terminal protease family protein KD35_02900 ENOG4105C7N Xanthine uracil vitamin C permease KD35_02910 ENOG4105BZU Histidine kinase KD35_02940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) KD35_02980 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KD35_03000 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_03020 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) KD35_03025 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit KD35_03030 ENOG4105C83 adenylosuccinate lyase KD35_03040 ENOG4105VR9 phosphoribosylformylglycinamidine synthase KD35_03065 ENOG4108V3E phosphoribosylglycinamide formyltransferase KD35_03075 ENOG4105C12 Phosphoribosylglycinamide synthetase KD35_03100 ENOG4105C4R Atp-dependent dna helicase KD35_03130 ENOG4108W2Y isochorismatase KD35_03135 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KD35_03140 ENOG4108UMI ABC transporter, permease KD35_03145 ENOG4105D01 (LipO)protein KD35_03165 ENOG410834F Transcriptional regulator KD35_03190 ENOG4105CBD Diacylglycerol kinase KD35_03195 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) KD35_03200 ENOG4108JPW Aminotransferase KD35_03210 ENOG4105C26 Dehydrogenase KD35_03215 ENOG4105KPY Small multidrug resistance protein KD35_03235 ENOG4105D9N nucleoside KD35_03240 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KD35_03255 ENOG4108W15 Protein of unknown function (DUF1456) KD35_03270 ENOG4105DTQ mandelate racemase muconate lactonizing KD35_03280 ENOG4105DFD Na H antiporter KD35_03300 ENOG4105D3R alkyl hydroperoxide reductase KD35_03305 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) KD35_03315 ENOG4107W7X Aldolase KD35_03320 ENOG4105EHG Permease protein KD35_03325 ENOG4105DQ5 transport system permease protein KD35_03330 ENOG4108V5C ABC transporter KD35_03355 ENOG4106UIA KD35_03360 ENOG4106UIA KD35_03385 ENOG4105BZU Histidine kinase KD35_03405 ENOG410756H nucleotidyltransferase KD35_03410 ENOG4105D2S major facilitator superfamily KD35_03425 ENOG4105E5Q amino acid AbC transporter KD35_03430 ENOG4105EAB amino acid AbC transporter KD35_03445 ENOG4105C8Q Methyl-accepting chemotaxis KD35_03450 ENOG4105C8Q Methyl-accepting chemotaxis KD35_03460 ENOG4105CI1 PTS System KD35_03490 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter KD35_03505 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component KD35_03520 ENOG4105C5H ABC transporter KD35_03545 ENOG41062JF Transcriptional regulator KD35_03565 ENOG4105DEU major facilitator superfamily KD35_03580 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) KD35_03595 ENOG4108N0M stress protein KD35_03600 ENOG4106FN3 tellurium resistance protein KD35_03605 ENOG4106FN3 tellurium resistance protein KD35_03610 ENOG4107TS3 membrane protein, TerC KD35_03615 ENOG4108TTB tellurium resistance protein KD35_03635 ENOG4105KJF protein tyrosine phosphatase KD35_03645 ENOG4107U9T Pfam:Ribonuclease_BN KD35_03650 ENOG4105C59 p-type ATPase KD35_03655 ENOG4108IPJ Membrane KD35_03675 ENOG4107ZTW SNARE associated Golgi KD35_03690 ENOG410606W general stress protein KD35_03695 ENOG4105UPD Calcium Proton KD35_03735 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) KD35_03740 ENOG4105VTR Integrase KD35_03745 ENOG4108IMY Transcriptional regulator KD35_04020 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) KD35_04030 ENOG4108JUB Transcriptional regulator KD35_04040 ENOG4108IQI permease KD35_04075 ENOG4105CSV Glutaminase KD35_04085 ENOG4108A04 Beta-lactamase KD35_04100 ENOG4105CKK Glycosyl transferase, family 2 KD35_04110 ENOG4107QQG Dehydrogenase KD35_04115 ENOG4105C3I Nad-dependent epimerase dehydratase KD35_04135 ENOG4105F1A Pyruvate formate-lyase KD35_04155 ENOG4105CI2 imidazolone-5-propionate hydrolase KD35_04160 ENOG4105ECP epimerase KD35_04190 ENOG41067AE Membrane-bound metal-dependent hydrolase KD35_04195 ENOG4105CEN a g-specific adenine glycosylase KD35_04200 ENOG4106BXE KD35_04220 ENOG4105BZ1 (ABC) transporter KD35_04225 ENOG4107NBY Membrane KD35_04230 ENOG4105CBC glutamate synthase KD35_04240 ENOG4108IUW ABC transporter KD35_04260 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KD35_04265 ENOG4105G5W regulator Fur family KD35_04380 ENOG4108JQC penicillin-binding protein 1A KD35_04385 ENOG4107ZQN disulfide bond KD35_04395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) KD35_04405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) KD35_04410 ENOG4105BZU Histidine kinase KD35_04420 ENOG4105CYN Serine protein kinase KD35_04445 ENOG4105C94 Transporter KD35_04460 ENOG4105DZ6 Band 7 protein KD35_04470 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism KD35_04475 ENOG4108MRH transcriptional regulatory protein KD35_04480 ENOG4105D4T Citrate transporter KD35_04500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KD35_04505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KD35_04510 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component KD35_04515 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component KD35_04520 ENOG4105BZ7 extracellular solute-binding protein family 1 KD35_04525 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) KD35_04530 ENOG4108STX response regulator KD35_04535 ENOG4105US7 Histidine kinase KD35_04560 ENOG4108MRH transcriptional regulatory protein KD35_04570 ENOG4105C6K Malic enzyme KD35_04580 ENOG4108UZ3 Transporter KD35_04585 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KD35_04595 ENOG4105BZU Histidine kinase KD35_04600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_04610 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) KD35_04615 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KD35_04620 ENOG4108JB9 formate dehydrogenase KD35_04640 ENOG4105CUB amino acid KD35_04650 ENOG4105C59 p-type ATPase KD35_04655 ENOG4105DAP Nicotinate phosphoribosyltransferase KD35_04685 ENOG41073R8 VanW family KD35_04690 ENOG4108KGH TRANSCRIPTIONal KD35_04695 ENOG4105D9N nucleoside KD35_04700 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase KD35_04705 ENOG4105C37 (CBS) domain KD35_04710 ENOG4108IJ0 Aspartate ammonia-lyase KD35_04715 ENOG4105DAA L-lactate KD35_04730 ENOG4105DUX Transporter KD35_04735 ENOG4108MES Periplasmic binding protein KD35_04740 ENOG4105DQ5 transport system permease protein KD35_04745 ENOG4108IHU transport system permease protein KD35_04750 ENOG4105E0A ABC, transporter KD35_04755 ENOG4105DMQ Methyltransferase KD35_04765 ENOG4105EXW epimerase dehydratase KD35_04775 ENOG4107T89 von Willebrand factor, type A KD35_04780 ENOG4105GMT ATPase associated with various cellular activities aaa_5 KD35_04785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KD35_04800 ENOG4105BZU Histidine kinase KD35_04805 ENOG4105D5Q Arginine ornithine antiporter KD35_04810 ENOG4107414 GntR family transcriptional regulator KD35_04815 ENOG4105C5Y PTS System KD35_04820 ENOG4105CG3 alpha amylase, catalytic region KD35_04835 ENOG4105E1K spore germination protein KD35_04845 ENOG4105CRN Aminoglycoside phosphotransferase KD35_04850 ENOG4105BZG amino acid carrier protein KD35_04855 ENOG4105CDA abc transporter atp-binding protein KD35_04860 ENOG4105CT1 (ABC) transporter KD35_04865 ENOG4105EAD ABC transporter KD35_04870 ENOG4105DRP amino acid AbC transporter KD35_04875 ENOG4108IQI permease KD35_04900 ENOG4105D29 Helix-turn-helix type 11 domain protein KD35_04905 ENOG4105NAE bifunctional deaminase-reductase domain protein KD35_04910 ENOG4105BZU Histidine kinase KD35_04925 ENOG4105CHH sulfate transporter KD35_04930 ENOG41068KF Universal stress protein KD35_04940 ENOG4105DEF Extracellular solute-binding protein, family 5 KD35_04950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KD35_04955 ENOG4108JQ7 (ABC) transporter KD35_04965 ENOG4105CXY transporter KD35_04970 ENOG41067TZ transcriptional regulator, MarR family KD35_04975 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_04980 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_04985 ENOG4105ETE Transcriptional regulator (LacI family KD35_04990 ENOG4108RVA ribokinase KD35_05000 ENOG4105C2J ABC transporter KD35_05005 ENOG4105CNN ABC, transporter KD35_05010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator KD35_05015 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) KD35_05075 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KD35_05080 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KD35_05085 ENOG41069ER domain protein KD35_05090 ENOG4105VZ8 Transcriptional regulator KD35_05095 ENOG4107D63 KD35_05105 ENOG4105DUX Transporter KD35_05125 ENOG4105C85 amino acid KD35_05130 ENOG4105C7N Xanthine uracil vitamin C permease KD35_05170 ENOG4105BZ9 Cytochrome C oxidase, subunit I KD35_05175 ENOG4105E2S oxidase) subunit II KD35_05180 ENOG4108IQI permease KD35_05195 ENOG4106CAD Protein of unknown function (DUF3311) KD35_05200 ENOG4105E1V na solute symporter KD35_05215 ENOG4108NHD germination protein KD35_05225 ENOG4105CE1 Ferrous iron transport protein b KD35_05230 ENOG4105CE1 Ferrous iron transport protein b KD35_05235 ENOG4105CE1 Ferrous iron transport protein b KD35_05240 ENOG4105CVA phosphate KD35_05245 ENOG4105C8U phosphate abc transporter KD35_05250 ENOG4105E2Z phosphate ABC transporter (Permease KD35_05380 ENOG41080XQ Signal transduction protein with cbs domains KD35_05405 ENOG4105ETU transcriptional activator (TenA KD35_05415 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component KD35_05425 ENOG4108VEU Thiamine monophosphate synthase KD35_05430 ENOG41080HI glycine oxidase KD35_05445 ENOG4105D06 uba thif-type nad fad binding protein KD35_05450 ENOG4105DWF phosphomethylpyrimidine kinase KD35_05505 ENOG4108INS Transcriptional regulator KD35_05520 ENOG4105C7N Xanthine uracil vitamin C permease KD35_05550 ENOG4105C5Y PTS System KD35_05610 ENOG4107Y03 Nitroreductase KD35_05615 ENOG4105ED1 spovr family KD35_05640 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase KD35_05645 ENOG4105XTG Pfam:DUF156 KD35_05650 ENOG4105VFE sira family KD35_05655 ENOG4107TPS domain protein KD35_05660 ENOG4105VFE sira family KD35_05665 ENOG41085GJ domain protein KD35_05675 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase KD35_05680 ENOG41087NI Sulfite exporter TauE/SafE KD35_05690 ENOG4108KGH TRANSCRIPTIONal KD35_05715 ENOG4105EMD TRANSCRIPTIONal KD35_05720 ENOG4105VCP PTS System KD35_05725 ENOG4105VZJ PTS System KD35_05745 ENOG41069ER domain protein KD35_05750 ENOG4107RBB ABC transporter, permease KD35_05755 ENOG4105C19 ABC transporter KD35_05785 ENOG4105WEF catalase KD35_05820 ENOG4107T5V SNARE associated Golgi KD35_05855 ENOG4105CUB amino acid KD35_05860 ENOG4107RWR Sodium hydrogen exchanger KD35_05870 ENOG4106KNT transcriptional regulator KD35_05905 ENOG4108PCN EamA-like transporter family KD35_05910 ENOG4108YXU transcriptional regulator AsnC family KD35_05920 ENOG4105KPY Small multidrug resistance protein KD35_05925 ENOG4105KPY Small multidrug resistance protein KD35_05950 ENOG4105NF4 modulator of drug activity KD35_05955 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) KD35_05960 ENOG4105E5W Transporter KD35_05970 ENOG4107RKG DJ-1/PfpI family KD35_05975 ENOG4105CH6 catalase KD35_05985 ENOG4105D5Q Arginine ornithine antiporter KD35_05990 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) KD35_06000 ENOG4105C26 Dehydrogenase KD35_06010 ENOG4105BZ1 (ABC) transporter KD35_06025 ENOG4105DRP amino acid AbC transporter KD35_06030 ENOG4105CDA abc transporter atp-binding protein KD35_06045 ENOG410839P KD35_06080 ENOG4107FQX Alpha-acetolactate decarboxylase KD35_06110 ENOG4105D4P Coproporphyrinogen iii oxidase KD35_06125 ENOG4105CHH sulfate transporter KD35_06165 ENOG4106AKK s-layer domain-containing protein KD35_06175 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KD35_06180 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KD35_06195 ENOG4105CGU Enoyl-CoA hydratase KD35_06215 ENOG4105DER m42 family KD35_06235 ENOG4105CTU Proline racemase KD35_06280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KD35_06290 ENOG4108JQ7 (ABC) transporter KD35_06320 ENOG4105CSH Transporter KD35_06330 ENOG4108MRH transcriptional regulatory protein KD35_06380 ENOG4105CDU Replicative dna helicase KD35_06420 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_06470 ENOG4107P5I polyketide synthase KD35_06475 ENOG4108IG5 Transcriptional regulator KD35_06495 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KD35_06515 ENOG4105CMT Dihydroxyacetone kinase KD35_06525 ENOG4105CMT Dihydroxyacetone kinase KD35_06530 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KD35_06535 ENOG410847I Transcriptional regulator, BadM Rrf2 family KD35_06560 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase KD35_06625 ENOG4105WN5 stage II sporulation protein KD35_06635 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_06645 ENOG4108MJI response regulator KD35_06650 ENOG4105BZU Histidine kinase KD35_06655 ENOG4105BZU Histidine kinase KD35_06680 ENOG4105K8R UPF0145 protein KD35_06715 ENOG4107VRP DNA repair exonuclease KD35_06720 ENOG4106D4I domain protein KD35_06725 ENOG4105D7V transposase KD35_06740 ENOG4108IND Tetr family transcriptional regulator KD35_06745 ENOG4105EQ0 Major Facilitator superfamily KD35_06755 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KD35_06765 ENOG4108MUZ hydrolase KD35_06785 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator KD35_06800 ENOG4105C6V Glycerol-3-phosphate dehydrogenase KD35_06815 ENOG4105EMN RNA polymerase sigma factor KD35_06840 ENOG4105C57 major facilitator superfamily KD35_06845 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_06855 ENOG4105EEM helicase KD35_06860 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KD35_06890 ENOG4105K59 histidine triad (HIT) protein KD35_06920 ENOG410905X membrane-flanked domain protein KD35_06930 ENOG4105CKV Membrane KD35_06975 ENOG410905X membrane-flanked domain protein KD35_06980 ENOG4105CKV Membrane KD35_06985 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation KD35_06990 ENOG4105BZ4 penicillin-binding protein KD35_06995 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) KD35_07005 ENOG4105C1Q protoporphyrinogen oxidase KD35_07030 ENOG4105NA0 Transcriptional regulator KD35_07045 ENOG4105ECB domain protein KD35_07075 ENOG4106AXD KD35_07080 ENOG4108RQ5 Beta-lactamase domain-containing protein KD35_07085 ENOG4105DF9 Lipoate-protein, ligase KD35_07095 ENOG4105CEY Amp-dependent synthetase and ligase KD35_07125 ENOG4105CNA YD repeat protein KD35_07160 ENOG4105ENX hydrolase KD35_07170 ENOG4107RN3 metallophosphoesterase KD35_07175 ENOG4107TVP HD domain protein KD35_07185 ENOG4108AEY RNA polymerase sigma factor KD35_07190 ENOG41086D8 Transcriptional regulator KD35_07210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_07235 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 KD35_07240 ENOG4105C8Q Methyl-accepting chemotaxis KD35_07260 ENOG4105ZU5 s-layer protein KD35_07265 ENOG4107QP3 malate synthase g KD35_07280 ENOG4105VEQ Cold shock protein KD35_07295 ENOG4105XVF Competence transcription factor KD35_07310 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination KD35_07315 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation KD35_07360 ENOG4105ERH Fumarylacetoacetate hydrolase KD35_07385 ENOG4105CAQ asparagine synthetase KD35_07390 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) KD35_07395 ENOG4105CH6 catalase KD35_07400 ENOG4105BZU Histidine kinase KD35_07425 ENOG4105QNR S1 RNA binding domain protein KD35_07435 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KD35_07445 ENOG4107AYK membrAne KD35_07450 ENOG41073B9 KD35_07460 ENOG4108KP7 hydrolase KD35_07475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit KD35_07500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KD35_07505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) KD35_07520 ENOG4105C31 Tryptophanyl-tRNA synthetase KD35_07535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component KD35_07540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KD35_07550 ENOG4108JQ7 (ABC) transporter KD35_07555 ENOG4105UQX Mate efflux family protein KD35_07580 ENOG4108ZCF integral membrane protein KD35_07590 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KD35_07600 ENOG4105DPN Oligoendopeptidase f KD35_07615 ENOG4108Z18 K06886 hemoglobin KD35_07620 ENOG4105MIX Adenylate cyclase KD35_07635 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) KD35_07640 ENOG4105EMS pseudouridine synthase KD35_07660 ENOG4105K64 Glycosyl transferase, family 2 KD35_07680 ENOG4107TVC Glycosyl transferase, family 2 KD35_07700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) KD35_07705 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase KD35_07715 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase KD35_07765 ENOG4108WVJ 2'-5' rna ligase KD35_07790 ENOG4105CK7 Sodium proline symporter KD35_07800 ENOG4105CRQ synthase (Component I) KD35_07805 ENOG4105DDQ anthranilate synthase KD35_07895 ENOG4105C7S Dehydrogenase KD35_07905 ENOG4105VZ8 Transcriptional regulator KD35_07965 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) KD35_08000 ENOG4105C26 Dehydrogenase KD35_08005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KD35_08010 ENOG4105F38 ABC transporter, permease KD35_08015 ENOG4105D38 putrescine abc transporter KD35_08020 ENOG4107RUE extracellular solute-binding protein family 1 KD35_08030 ENOG4105EYF MMPL domain protein KD35_08040 ENOG4108YBP pseudouridine synthase KD35_08050 ENOG4105K4I Scp-like extracellular KD35_08055 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) KD35_08060 ENOG4105CQB FAD linked oxidase domain protein KD35_08075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_08080 ENOG4105BZU Histidine kinase KD35_08085 ENOG4105JXH GntR family transcriptional regulator KD35_08105 ENOG4106A3R peptidase KD35_08115 ENOG4108QTI )-transporter KD35_08120 ENOG4107TS3 membrane protein, TerC KD35_08125 ENOG4105CZN Potassium uptake protein KD35_08130 ENOG410681C small acid-soluble spore protein KD35_08135 ENOG4108Z7G MaoC domain protein dehydratase KD35_08155 ENOG4105CHR reductase KD35_08165 ENOG4105MWK D-amino acid dehydrogenase, small subunit KD35_08185 ENOG4105C4Y ABC transporter KD35_08195 ENOG4107RCV ABC transporter, permease KD35_08200 ENOG4108KAZ Involved in phosphonate degradation (By similarity) KD35_08215 ENOG4105E98 transcriptional regulator DeoR family KD35_08240 ENOG4105PXI polysaccharide deacetylase KD35_08250 ENOG4105BZU Histidine kinase KD35_08255 ENOG41090MY MarR family Transcriptional regulator KD35_08265 ENOG4106DF1 KD35_08275 ENOG4105BZU Histidine kinase KD35_08285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase KD35_08290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) KD35_08335 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) KD35_08355 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) KD35_08360 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KD35_08365 ENOG4105CZV ABC transporter KD35_08375 ENOG4105CJ1 ABC, transporter KD35_08415 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KD35_08420 ENOG4105EA8 2-Nitropropane dioxygenase KD35_08425 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KD35_08435 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein KD35_08460 ENOG4105NQC Flavodoxin KD35_08495 ENOG4107QMU Mate efflux family protein KD35_08500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) KD35_08530 ENOG4105CZN Potassium uptake protein KD35_08535 ENOG41063Y9 KD35_08540 ENOG4105KBJ sporulation protein ytfj KD35_08570 ENOG4105CM2 brancheD-chain amino acid aminotransferase KD35_08575 ENOG4105C7K acetolactate synthase KD35_08580 ENOG4108ZP8 Acetolactate synthase small subunit KD35_08585 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KD35_08595 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) KD35_08620 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) KD35_08655 ENOG4107RVV histidinol phosphate phosphatase, hisj family KD35_08670 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase KD35_08675 ENOG4105E0M Sulfatase KD35_08685 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) KD35_08705 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) KD35_08710 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) KD35_08720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KD35_08725 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KD35_08730 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KD35_08740 ENOG4105C8J )-transporter KD35_08760 ENOG4105DFD Na H antiporter KD35_08780 ENOG4105ENE Histidine kinase KD35_08785 ENOG4105WH1 Two component transcriptional regulator luxr family KD35_08805 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) KD35_08830 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) KD35_08855 ENOG4105CJ3 phosphate transporter KD35_08860 ENOG4107GRR phosphate transport regulator KD35_08865 ENOG4105BZ4 penicillin-binding protein KD35_08880 ENOG4105BZU Histidine kinase KD35_08885 ENOG4105I3N Conserved Protein KD35_08900 ENOG4105BZU Histidine kinase KD35_08935 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KD35_08940 ENOG4105DZ1 carboxypeptidase KD35_08945 ENOG4108JIC nucleoside recognition domain protein KD35_08955 ENOG4105FE9 pseudouridine synthase KD35_08965 ENOG4107TWT Cytochrome c biogenesis protein KD35_08970 ENOG4105CRE cytochrome C KD35_08975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_08980 ENOG4105BZU Histidine kinase KD35_08985 ENOG4108WBT adenosyltransferase KD35_09000 ENOG4108SAX Membrane KD35_09010 ENOG4105T7X KD35_09015 ENOG4105C9U ATP-dependent DNA helicase RecQ KD35_09020 ENOG4105I7S Abortive infection protein KD35_09035 ENOG4107X2D transcriptional regulator, merr family KD35_09040 ENOG4108S6Z Negative regulator of genetic competence KD35_09065 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase KD35_09070 ENOG4107RB3 L-asparaginase KD35_09105 ENOG4105S2F KD35_09110 ENOG41065D1 KD35_09140 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) KD35_09155 ENOG4105XXQ heptaprenyl diphosphate synthase component I KD35_09165 ENOG4105EAH synthase KD35_09185 ENOG4105CIH Imidazole acetol-phosphate transaminase KD35_09190 ENOG41068YB TPR repeat-containing protein KD35_09205 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) KD35_09210 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) KD35_09215 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit KD35_09245 ENOG4108JYZ YitT family KD35_09250 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase KD35_09265 ENOG4105FJR Lmbe family KD35_09270 ENOG4105CPK Glycosyl transferase (Group 1 KD35_09310 ENOG4105DVT helicase KD35_09315 ENOG4105YAC KD35_09335 ENOG4105CSM endonuclease III KD35_09395 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) KD35_09405 ENOG4105DVT helicase KD35_09410 ENOG4105CTD carboxy-peptidase KD35_09425 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) KD35_09435 ENOG4105C2W permease KD35_09440 ENOG4105DHF Membrane KD35_09445 ENOG410890F Dynamin family KD35_09455 ENOG4108W0I acetyltransferase KD35_09465 ENOG4105KHC sulfurtransferase KD35_09480 ENOG4106032 Glutathionylspermidine synthase KD35_09540 ENOG4105CPK Glycosyl transferase (Group 1 KD35_09555 ENOG4108SZE gCN5-related N-acetyltransferase KD35_09575 ENOG41081VK Ribonuclease KD35_09640 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KD35_09650 ENOG4107RWR Sodium hydrogen exchanger KD35_09655 ENOG4105CN5 Metallo-Beta-Lactamase KD35_09660 ENOG4108Z5V transcriptional regulator, merr family KD35_09670 ENOG4105H67 Protein of unknown function (DUF421) KD35_09675 ENOG41080C8 DUF218 domain KD35_09730 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) KD35_09740 ENOG4107R0U MotA TolQ exbB proton channel KD35_09745 ENOG4105ER2 Ompa motb domain protein KD35_09750 ENOG4107YTP response regulator receiver protein KD35_09760 ENOG4105DD5 Flagellar motor switch protein KD35_09775 ENOG4105BZU Histidine kinase KD35_09795 ENOG4105E1Q flagellar hook-associated protein KD35_09800 ENOG4105DTJ flagellar hook-associated protein KD35_09825 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) KD35_09830 ENOG4108ZC9 flagellar basal-body rod protein flgc KD35_09835 ENOG41075Z6 flagellar hook-basal body complex protein fliE KD35_09840 ENOG4107U2N Flagellar M-ring protein KD35_09850 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) KD35_09885 ENOG4105BZE flagellar hook protein, FlgE KD35_09900 ENOG4107R88 Chemotaxis protein (CheV) KD35_09910 ENOG4105K64 Glycosyl transferase, family 2 KD35_09940 ENOG4107TVC Glycosyl transferase, family 2 KD35_09965 ENOG4105I03 Flagellin KD35_09970 ENOG4105E4C Lytic transglycosylase catalytic KD35_09985 ENOG4105DD5 Flagellar motor switch protein KD35_09995 ENOG4105CN7 Flagellar biosynthetic protein FliP KD35_10000 ENOG4105VS8 Flagellar biosynthetic protein fliq KD35_10010 ENOG4105D00 flagellar biosynthetic protein flhB KD35_10015 ENOG4105D7B Flagellar biosynthesis protein flha KD35_10020 ENOG4105FZW flagellar biosynthesis regulator FlhF KD35_10025 ENOG4105KTQ flagellar basal-body rod protein KD35_10030 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KD35_10055 ENOG4108RZE Tetr family transcriptional regulator KD35_10075 ENOG4105KAC Antibiotic biosynthesis monooxygenase KD35_10100 ENOG4105DUM transcriptional regulator, lysR family KD35_10105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) KD35_10110 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein KD35_10115 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component KD35_10120 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) KD35_10155 ENOG4105CVJ phosphoglycerate mutase KD35_10200 ENOG4106BRA Membrane KD35_10235 ENOG4105CJ1 ABC, transporter KD35_10255 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) KD35_10265 ENOG4108IJ0 Aspartate ammonia-lyase KD35_10270 ENOG4105C6K Malic enzyme KD35_10340 ENOG4105FVX KD35_10380 ENOG4105CSR polyphosphate kinase 2 KD35_10400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) KD35_10415 ENOG4105EU0 Major facilitator Superfamily KD35_10420 ENOG4105C6T cysteine synthase KD35_10440 ENOG4105C8J )-transporter KD35_10450 ENOG4105X5K response regulator receiver protein KD35_10455 ENOG4105H67 Protein of unknown function (DUF421) KD35_10470 ENOG4106KE4 Dehydrogenase KD35_10485 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) KD35_10490 ENOG4105CHR reductase KD35_10495 ENOG4105CM2 brancheD-chain amino acid aminotransferase KD35_10500 ENOG4105C7K acetolactate synthase KD35_10505 ENOG4108ZP8 Acetolactate synthase small subunit KD35_10510 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase KD35_10520 ENOG4105C7B Threonine dehydratase KD35_10545 ENOG4105C6X Major Facilitator KD35_10550 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b KD35_10560 ENOG4105DY9 regulatoR KD35_10565 ENOG4105CYC Transferase KD35_10585 ENOG4105F6J Alpha beta hydrolase fold KD35_10590 ENOG4108J59 Extracellular solute-binding protein, family 5 KD35_10620 ENOG41068WN KD35_10640 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) KD35_10645 ENOG4105C72 UPF0176 protein KD35_10655 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) KD35_10690 ENOG4107RHR regulatoR KD35_10700 ENOG4105D9N nucleoside KD35_10705 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) KD35_10740 ENOG4107RAQ aminopeptidase KD35_10745 ENOG4107STQ Multicopper oxidase KD35_10790 ENOG4108T5E Copper resistance protein KD35_10795 ENOG4105KTB nuclear export factor GLE1 KD35_10805 ENOG4107RT3 EamA-like transporter family KD35_10810 ENOG4105GZI Transcriptional regulator KD35_10815 ENOG4108Z40 Transcriptional regulator KD35_10820 ENOG4107ZXU DSBA oxidoreductase KD35_10825 ENOG4108TVJ Nitroreductase KD35_10835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KD35_10840 ENOG4106F5Q Membrane KD35_10845 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KD35_10855 ENOG4105CKI cobalamin synthesis protein KD35_10875 ENOG4108Z7G MaoC domain protein dehydratase KD35_10880 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KD35_10890 ENOG4105C0Z ABC transporter KD35_10895 ENOG4108IV0 ABC, transporter KD35_10900 ENOG4105C32 Amino acid ABC transporter (Permease) KD35_10910 ENOG4105SKE transcriptional Regulator LysR family KD35_10930 ENOG4105YGB Transcriptional regulator KD35_10940 ENOG4105C4M (Ubiquinol oxidase) subunit I KD35_10945 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KD35_10950 ENOG4108JJ9 ABC, transporter KD35_10955 ENOG4108JJ8 (ABC) transporter KD35_11000 ENOG4105BZ1 (ABC) transporter KD35_11005 ENOG4105BZ1 (ABC) transporter KD35_11010 ENOG4105EFI regulatoR KD35_11015 ENOG4105BZU Histidine kinase KD35_11035 ENOG41075D4 Aminoglycoside 6-adenylyltransferase KD35_11040 ENOG4108ZJ4 polysaccharide deacetylase KD35_11060 ENOG4105D6E homoserine dehydrogenase KD35_11085 ENOG4108KGH TRANSCRIPTIONal KD35_11095 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_11100 ENOG4105BZU Histidine kinase KD35_11105 ENOG4107VMI polysaccharide deacetylase KD35_11115 ENOG4105KT7 mgtC SapB transporter KD35_11120 ENOG4105VRR gCN5-related N-acetyltransferase KD35_11130 ENOG4105DUU IucA IucC family protein KD35_11135 ENOG4105CEY Amp-dependent synthetase and ligase KD35_11150 ENOG4108WBH protein TIM barrel KD35_11155 ENOG4105YWU small acid-soluble spore protein KD35_11165 ENOG4108ZUB Lysine exporter protein (Lyse ygga) KD35_11215 ENOG4105KRN Transcriptional regulator, abrb family KD35_11225 ENOG4105YVS arsR family transcriptional regulator KD35_11230 ENOG4107SET aldo keto reductase KD35_11235 ENOG4107XZQ multidrug resistance protein KD35_11260 ENOG4105C8Q Methyl-accepting chemotaxis KD35_11280 ENOG4108K88 Membrane KD35_11285 ENOG4108WPJ Ferritin-like domain KD35_11300 ENOG4105DEN Luciferase family KD35_11320 ENOG4107QM2 Aldo Keto reductase KD35_11325 ENOG4105CKI cobalamin synthesis protein KD35_11395 ENOG4105DSE periplasmic solute binding protein KD35_11405 ENOG4105K4T epimerase KD35_11415 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KD35_11440 ENOG4105CVJ phosphoglycerate mutase KD35_11460 ENOG4107T5V SNARE associated Golgi KD35_11475 ENOG4108PJD permease KD35_11485 ENOG4108S4H thioesterase Superfamily protein KD35_11490 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) KD35_11510 ENOG4105SXS Protein of unknown function (DUF456) KD35_11515 ENOG4105C37 (CBS) domain KD35_11535 ENOG4108Z7R Chaperone CsaA KD35_11555 ENOG4108ZRV stage ii sporulation protein p KD35_11565 ENOG4108VXD carboxy-peptidase KD35_11575 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) KD35_11600 ENOG4108X4Q Hydrolase KD35_11610 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) KD35_11615 ENOG4107RBS Methyltransferase KD35_11630 ENOG41087PP glycosyltransferase MGT family KD35_11635 ENOG4108JYZ YitT family KD35_11640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family KD35_11665 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) KD35_11715 ENOG4105KBJ sporulation protein ytfj KD35_11740 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) KD35_11760 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) KD35_11765 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_11775 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein KD35_11780 ENOG4105EMN RNA polymerase sigma factor KD35_11805 ENOG4108V06 Glutathione peroxidase KD35_11820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KD35_11840 ENOG4108IUE nitrate reductase beta subunit KD35_11845 ENOG4105R3A Nitrate reductase KD35_11870 ENOG4107V6Q Cyclic nucleotide-binding domain KD35_11875 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) KD35_11880 ENOG4105D06 uba thif-type nad fad binding protein KD35_11885 ENOG4105CVM Molybdenum cofactor synthesis domain protein KD35_11890 ENOG4108ZAF Molybdopterin KD35_11915 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein KD35_11920 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein KD35_11925 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) KD35_11930 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit KD35_11935 ENOG4108IFG nitrite reductase, (NAD(P)H) KD35_11940 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) KD35_11975 ENOG4105MCT stage V sporulation protein S KD35_11990 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KD35_12010 ENOG4105C5H ABC transporter KD35_12025 ENOG4108UUM single-stranded DNA-binding protein KD35_12040 ENOG41061H0 Monooxygenase KD35_12060 ENOG4107YX5 Pfam:DUF548 KD35_12065 ENOG4105C75 arginyL-tRNA synthetase KD35_12090 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KD35_12105 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) KD35_12110 ENOG4105C5S asparaginyl-tRNA synthetase KD35_12130 ENOG4105EC2 ftsk spoIIIe KD35_12225 ENOG4105BZW Glycerate kinase KD35_12230 ENOG4107QPK )-transporter KD35_12235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_12240 ENOG41062D9 Histidine kinase KD35_12255 ENOG4105C8J )-transporter KD35_12275 ENOG4107XGZ Hydrolase KD35_12280 ENOG4105CY2 Citrate transporter KD35_12285 ENOG4105C0A alcohol dehydrogenase KD35_12300 ENOG4105KD7 acetyltransferase KD35_12330 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 KD35_12350 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) KD35_12365 ENOG4107RVG penicillin-binding protein KD35_12370 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) KD35_12375 ENOG4105E9Q Acyl-transferase KD35_12380 ENOG4108UT2 hemolysin iii KD35_12390 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) KD35_12400 ENOG4108RCR degv family KD35_12405 ENOG4105E8R UPF0173 metal-dependent hydrolase KD35_12410 ENOG4108KF3 Electron transport protein SCO1 SenC KD35_12415 ENOG4107Y70 Heat shock protein KD35_12420 ENOG4105CAQ asparagine synthetase KD35_12440 ENOG4108MES Periplasmic binding protein KD35_12445 ENOG4105F0I Aminotransferase KD35_12480 ENOG4105D8X mechanosensitive ion channel KD35_12485 ENOG4105BZU Histidine kinase KD35_12490 ENOG4105WH1 Two component transcriptional regulator luxr family KD35_12500 ENOG4106KNT transcriptional regulator KD35_12535 ENOG4105CMG Carbohydrate kinase KD35_12540 ENOG4105CMG Carbohydrate kinase KD35_12570 ENOG4108IJ8 ABC transporter KD35_12575 ENOG4105E90 ABC transporter KD35_12610 ENOG4105C37 (CBS) domain KD35_12635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KD35_12650 ENOG4107S4Y M20 DapE family protein YgeY KD35_12655 ENOG4108TSC N-acetyltransferase KD35_12660 ENOG4108JUB Transcriptional regulator KD35_12665 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein KD35_12705 ENOG4108N23 SpoOM-related protein KD35_12710 ENOG410841Q phosphoesterase PA-phosphatase related protein KD35_12720 ENOG4105SZ6 Thioredoxin KD35_12735 ENOG4108IBT Inherit from COG: transposase KD35_12840 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) KD35_12880 ENOG4105BZ4 penicillin-binding protein KD35_12885 ENOG4105CZM Major Facilitator KD35_12890 ENOG4105W8X HesB YadR YfhF-family protein KD35_12900 ENOG4105DXD 2-methylcitrate dehydratase KD35_12905 ENOG4105CR4 methylisocitrate lyase KD35_12910 ENOG4105C1G acyl-Coa dehydrogenase KD35_12915 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase KD35_12925 ENOG4105N14 lysine exporter protein LysE YggA KD35_12930 ENOG4105E39 Enoyl-CoA hydratase KD35_12945 ENOG4107RFY SbcCD D subunit KD35_12950 ENOG4105EYH Exonuclease KD35_12980 ENOG4105FCD Major Facilitator KD35_12985 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase KD35_12990 ENOG4105E4F Isochorismate synthase KD35_12995 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase KD35_13000 ENOG4105WQI isochorismatase KD35_13005 ENOG4105CEY Amp-dependent synthetase and ligase KD35_13010 ENOG4105WQT MbtH domain protein KD35_13015 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_13030 ENOG4105K70 DNA-binding protein KD35_13050 ENOG4105BZG amino acid carrier protein KD35_13075 ENOG4105FE9 pseudouridine synthase KD35_13080 ENOG4105C22 threonyL-tRNA synthetase KD35_13095 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KD35_13120 ENOG4108D32 Methyltransferase KD35_13150 ENOG41081I9 integral membrane protein KD35_13165 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) KD35_13175 ENOG4105EYF MMPL domain protein KD35_13200 ENOG4105WCN acetyltransferase KD35_13230 ENOG4105C1Q protoporphyrinogen oxidase KD35_13240 ENOG41068WN KD35_13250 ENOG4105VEQ Cold shock protein KD35_13270 ENOG410667J hydrolase KD35_13315 ENOG4107V2S Transcriptional regulator KD35_13320 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KD35_13335 ENOG4105DND Transcriptional regulator KD35_13340 ENOG4108RPX mosc domain containing protein KD35_13355 ENOG4105BZ1 (ABC) transporter KD35_13360 ENOG4105BZ1 (ABC) transporter KD35_13380 ENOG4108JCI Transcriptional regulator KD35_13410 ENOG4108KPJ rna polymerase sigma factor KD35_13435 ENOG4105F32 YngK protein KD35_13460 ENOG4105RD7 BadF BadG BcrA BcrD KD35_13470 ENOG4107STF Involved in phosphonate degradation (By similarity) KD35_13490 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) KD35_13505 ENOG4105C1J atp-dependent rna helicase KD35_13520 ENOG4108RZE Tetr family transcriptional regulator KD35_13540 ENOG41088CC tellurite resistance protein tehB KD35_13550 ENOG4108I0C methyltransferase KD35_13555 ENOG4107RA9 decarboxylase KD35_13560 ENOG41090HR transcriptional regulator KD35_13600 ENOG4105CIN aminoacyl-histidine dipeptidase KD35_13625 ENOG4107RF6 penicillin-binding protein KD35_13640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KD35_13645 ENOG4105ETE Transcriptional regulator (LacI family KD35_13650 ENOG4105IE8 Alpha-ketoglutarate permease KD35_13655 ENOG4105CK5 oxidoreductase KD35_13680 ENOG4105D2N Aldolase KD35_13685 ENOG4105DH8 myo-inositol catabolism KD35_13700 ENOG4105CGH 5'-nucleotidase KD35_13720 ENOG4105VZ8 Transcriptional regulator KD35_13735 ENOG4108VXD carboxy-peptidase KD35_13755 ENOG41067SE Tetr family transcriptional regulator KD35_13760 ENOG4105C5H ABC transporter KD35_13770 ENOG4105BZU Histidine kinase KD35_13780 ENOG4106ANW SMI1_KNR4 KD35_13785 ENOG4105CEP NADH dehydrogenase KD35_13790 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) KD35_13805 ENOG4105CJ1 ABC, transporter KD35_13815 ENOG4107Z3H Transcriptional regulator, TetR family KD35_13830 ENOG4105C1G acyl-Coa dehydrogenase KD35_13835 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KD35_13840 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit KD35_13845 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase KD35_13850 ENOG4105E39 Enoyl-CoA hydratase KD35_13855 ENOG4107QX3 carboxylase KD35_13860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KD35_13870 ENOG4105WCN acetyltransferase KD35_13875 ENOG4105DBI uridine monophosphokinase KD35_13890 ENOG4105DZ1 carboxypeptidase KD35_13905 ENOG4105T9C HD domain KD35_13915 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) KD35_13955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KD35_13955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KD35_13970 ENOG4105FQP Beta-lactamase KD35_13980 ENOG4107Y80 Major Facilitator superfamily KD35_14000 ENOG4105CUV Homoserine Kinase KD35_14035 ENOG4105CPQ Dehydrogenase KD35_14050 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KD35_14055 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KD35_14150 ENOG4105ETU transcriptional activator (TenA KD35_14260 ENOG410667J hydrolase KD35_14270 ENOG4105BZU Histidine kinase KD35_14275 ENOG4107RF6 penicillin-binding protein KD35_14295 ENOG4108JJB ABC transporter KD35_14305 ENOG4108HGU Histidine kinase KD35_14320 ENOG4105CB2 alcohol dehydrogenase KD35_14325 ENOG4105CJN penicillin-binding protein KD35_14335 ENOG4105FQP Beta-lactamase KD35_14370 ENOG4108V4B ThiJ pfpI KD35_14400 ENOG4107Y80 Major Facilitator superfamily KD35_14415 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KD35_14435 ENOG4107Y9U Membrane KD35_14470 ENOG4105FCD Major Facilitator KD35_14485 ENOG4105E09 nadh pyrophosphatase KD35_14490 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) KD35_14495 ENOG4108Z4K mutator MutT protein KD35_14530 ENOG4108XI2 Domain of unknown function (DUF1963) KD35_14560 ENOG4108NRW Phospholipase, patatin family KD35_14565 ENOG4105KWG Pfam:DUF1696 KD35_14600 ENOG4105PKS Excinuclease abc c subunit domain protein KD35_14640 ENOG4107VFR oxidoreductase KD35_14665 ENOG4105PAD Hydrolase KD35_14685 ENOG4105DY8 decarboxylase KD35_14700 ENOG4108IUM Glycogen debranching enzyme KD35_14725 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) KD35_14735 ENOG4105FDR Membrane KD35_14770 ENOG4108V3A UPF0421 protein KD35_14790 ENOG4105MSI germination protein ypeb KD35_14810 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) KD35_14815 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) KD35_14820 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) KD35_14825 ENOG4107Z3H Transcriptional regulator, TetR family KD35_14855 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family KD35_14875 ENOG4105E98 transcriptional regulator DeoR family KD35_14895 ENOG41062ES Transcriptional regulator KD35_14915 ENOG4107QKR Dehydrogenase KD35_14925 ENOG4107RUY (E1 component), alpha subunit KD35_14935 ENOG4105E1F short-chain dehydrogenase reductase KD35_14940 ENOG4105RHY Pfam:UPF0157 KD35_14975 ENOG4107SQ8 Glycine betaine KD35_14980 ENOG4108IJ7 Glycine betaine KD35_15005 ENOG4105E66 phosphoriboisomerase A KD35_15010 ENOG41082BV acetyltransferase KD35_15015 ENOG4108M1A Chitin-binding protein KD35_15060 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KD35_15110 ENOG4105EEM helicase KD35_15130 ENOG4105C9U ATP-dependent DNA helicase RecQ KD35_15185 ENOG4108M1A Chitin-binding protein KD35_15200 ENOG4105BZG amino acid carrier protein KD35_15205 ENOG4105C26 Dehydrogenase KD35_15210 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KD35_15215 ENOG4105CTU Proline racemase KD35_15220 ENOG4105CTU Proline racemase KD35_15225 ENOG41080HI glycine oxidase KD35_15265 ENOG4107T5V SNARE associated Golgi KD35_15280 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD KD35_15285 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) KD35_15300 ENOG4105DTQ mandelate racemase muconate lactonizing KD35_15340 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) KD35_15345 ENOG4105BZU Histidine kinase KD35_15350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_15390 ENOG4105EPR degv family KD35_15430 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) KD35_15435 ENOG4106K7D Major facilitator family transporter KD35_15455 ENOG4107BMA Transglycosylase associated protein KD35_15470 ENOG41089UC methyltransferase, type 11 KD35_15505 ENOG4105CHM Aminotransferase KD35_15535 ENOG4105DVE abc transporter atp-binding protein KD35_15585 ENOG4105C02 permease KD35_15600 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) KD35_15605 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component KD35_15610 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein KD35_15635 ENOG4105E09 nadh pyrophosphatase KD35_15655 ENOG4108AQF aminoglycoside N(3)-acetyltransferase KD35_15705 ENOG4107VC0 DNA alkylation repair enzyme KD35_15715 ENOG4107VMI polysaccharide deacetylase KD35_15725 ENOG4108ZCF integral membrane protein KD35_15730 ENOG4105E0M Sulfatase KD35_15735 ENOG4105C5H ABC transporter KD35_15745 ENOG4105EYF MMPL domain protein KD35_15750 ENOG4105EYF MMPL domain protein KD35_15755 ENOG4105EYF MMPL domain protein KD35_15760 ENOG41082JN Transcriptional regulator KD35_15780 ENOG4105CIH Imidazole acetol-phosphate transaminase KD35_15785 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase KD35_15790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase KD35_15825 ENOG41069ER domain protein KD35_15835 ENOG4105EMN RNA polymerase sigma factor KD35_15860 ENOG4105D4B ABC, transporter KD35_15870 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane KD35_15880 ENOG4105DKT Transcriptional regulator KD35_15895 ENOG41061GT Aldolase KD35_15915 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) KD35_15945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) KD35_15950 ENOG4105II7 pyrroline-5-carboxylate reductase KD35_15960 ENOG4107258 Transcriptional regulator KD35_15970 ENOG4105E0Y RtcB Protein KD35_15975 ENOG4105ECK Fatty Acid Desaturase KD35_15980 ENOG4105G6Z alkaline phosphatase KD35_15990 ENOG4105VMP Transcriptional regulator KD35_16005 ENOG41090T1 Membrane KD35_16015 ENOG4108WCX response regulator KD35_16025 ENOG41068WN KD35_16050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KD35_16100 ENOG4105CKK Glycosyl transferase, family 2 KD35_16110 ENOG4105C8Y Acetylornithine aminotransferase KD35_16150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 KD35_16160 ENOG4108TVJ Nitroreductase KD35_16165 ENOG4105FS7 Transcriptional regulator KD35_16200 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KD35_16210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) KD35_16240 ENOG4108XET gCN5-related N-acetyltransferase KD35_16320 ENOG410635A Membrane KD35_16325 ENOG4105KNA -acetyltransferase KD35_16330 ENOG4108IQI permease KD35_16340 ENOG4105F1N DNA alkylation repair KD35_16380 ENOG4107RF6 penicillin-binding protein KD35_16390 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) KD35_16425 ENOG4105P4J Allophanate hydrolase, subunit 1 KD35_16430 ENOG4107258 Transcriptional regulator KD35_16440 ENOG4106N3A copper homeostasis protein cutc KD35_16445 ENOG4108ZRV stage ii sporulation protein p KD35_16450 ENOG4108ZHR arsR family transcriptional regulator KD35_16460 ENOG4105FDT acyl-CoA dehydrogenase KD35_16480 ENOG4105DWD nucleoside recognition domain protein KD35_16510 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) KD35_16575 ENOG4105E2A Dehydrogenase KD35_16590 ENOG4108IJ0 Aspartate ammonia-lyase KD35_16595 ENOG4105HDK L-asparaginase KD35_16600 ENOG4108IMY Transcriptional regulator KD35_16610 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) KD35_16615 ENOG4105CUB amino acid KD35_16625 ENOG4105II7 pyrroline-5-carboxylate reductase KD35_16635 ENOG4105C6K Malic enzyme KD35_16645 ENOG4108NHD germination protein KD35_16650 ENOG4108NHD germination protein KD35_16655 ENOG4108Q8B Spore germination protein KD35_16675 ENOG4105CSV Glutaminase KD35_16705 ENOG4105CGH 5'-nucleotidase KD35_16710 ENOG4105CH6 catalase KD35_16720 ENOG4105CHJ isochorismatase hydrolase KD35_16785 ENOG4108606 TspO/MBR family KD35_16790 ENOG4105CVP deoxyribo-dipyrimidine photolyase KD35_16805 ENOG4108TWJ NADH dehydrogenase subunit 5 KD35_16810 ENOG4105GPN Uncharacterized conserved protein (DUF2294) KD35_16820 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KD35_16825 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) KD35_16830 ENOG4105DSE periplasmic solute binding protein KD35_16835 ENOG4105CC5 ABC transporter KD35_16840 ENOG4105DIK (ABC) transporter KD35_16870 ENOG4105D6J arsenicaL-resistance protein KD35_16875 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_16880 ENOG41085FC arsR family transcriptional regulator KD35_16895 ENOG4105F7F Chaperone KD35_16905 ENOG4105CHR reductase KD35_16910 ENOG4108YXU transcriptional regulator AsnC family KD35_16985 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) KD35_16995 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_17005 ENOG4105IIP Membrane KD35_17020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_17025 ENOG41062D9 Histidine kinase KD35_17055 ENOG4105K6H D-cysteine desulfhydrase KD35_17080 ENOG4105VZ8 Transcriptional regulator KD35_17095 ENOG4108NNI Beta-lactamase domain-containing protein KD35_17100 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase KD35_17110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) KD35_17115 ENOG4105JQZ Methyltransferase KD35_17130 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KD35_17135 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) KD35_17155 ENOG4105BZU Histidine kinase KD35_17170 ENOG4108U05 Transcriptional regulator KD35_17185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) KD35_17190 ENOG4105DJB Major Facilitator Superfamily KD35_17195 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) KD35_17200 ENOG4107QR9 Iron-sulfur cluster binding protein KD35_17210 ENOG4106P55 Transcriptional regulator KD35_17220 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A KD35_17255 ENOG4105TRI Hydrolase KD35_17290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KD35_17320 ENOG4107QJQ Mate efflux family protein KD35_17335 ENOG4105EQ0 Major Facilitator superfamily KD35_17340 ENOG4108JGH Tetr family transcriptional regulator KD35_17355 ENOG4105C44 Serine transporter KD35_17360 ENOG4105EJQ L-serine dehydratase KD35_17375 ENOG4108JPW Aminotransferase KD35_17390 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) KD35_17400 ENOG4105DVH amino acid KD35_17415 ENOG4108JQ1 Dehydrogenase KD35_17435 ENOG4108AEY RNA polymerase sigma factor KD35_17450 ENOG41082W1 Cupin 2, conserved barrel domain protein KD35_17460 ENOG410874W AraC family transcriptional regulator KD35_17475 ENOG4105HIR S-layer domain protein KD35_17515 ENOG4108ISG Major Facilitator KD35_17525 ENOG4107MII Sugar-specific transcriptional regulator TrmB KD35_17530 ENOG4105CZM Major Facilitator KD35_17550 ENOG4105DA5 (ABC) transporter KD35_17555 ENOG41069JR KD35_17565 ENOG4105RXJ KD35_17570 ENOG4105KPY Small multidrug resistance protein KD35_17575 ENOG4105KBX Transcriptional regulator, TetR family KD35_17590 ENOG4105CRW Short chain fatty acid transporter KD35_17600 ENOG4105DYS nad(p)h dehydrogenase (quinone) KD35_17630 ENOG4108JJB ABC transporter KD35_17635 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) KD35_17660 ENOG4108K8S endonuclease I KD35_17675 ENOG41067QW Transcriptional regulator KD35_17685 ENOG4108Z66 YbaK ebsC protein KD35_17690 ENOG4105CUT histidyl-tRNA synthetase KD35_17705 ENOG4105KVH Transcriptional regulator KD35_17710 ENOG4108RCM Nitroreductase KD35_17730 ENOG4108PSK reductase KD35_17740 ENOG4105CJ1 ABC, transporter KD35_17800 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_17805 ENOG4105DKQ ROK family KD35_17810 ENOG4106UW1 Major Facilitator superfamily KD35_17815 ENOG4108UW5 maltose o-acetyltransferase KD35_17825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) KD35_17830 ENOG4105C31 Tryptophanyl-tRNA synthetase KD35_17835 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) KD35_17860 ENOG4105DMQ Methyltransferase KD35_17870 ENOG4105EV4 Multidrug resistance protein mdtH KD35_17900 ENOG4105C37 (CBS) domain KD35_17915 ENOG4105DDN Pentapeptide repeat-containing protein KD35_17920 ENOG4105XDF Protein of unknown function (DUF1272) KD35_17925 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) KD35_17930 ENOG4105CMG Carbohydrate kinase KD35_17935 ENOG4105C6Z Gluconate KD35_17940 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) KD35_17955 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KD35_17960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase KD35_17965 ENOG4105CIS alcohol dehydrogenase KD35_17970 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone KD35_17990 ENOG4105EWI Short-chain dehydrogenase reductase Sdr KD35_17995 ENOG4105D4Y metalloprotease KD35_18015 ENOG4105CV8 reductase KD35_18020 ENOG4105F27 Major Facilitator KD35_18035 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) KD35_18040 ENOG4105C44 Serine transporter KD35_18075 ENOG4105KVH Transcriptional regulator KD35_18080 ENOG4108TZY GntR Family Transcriptional Regulator KD35_18090 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase KD35_18095 ENOG4105KVH Transcriptional regulator KD35_18100 ENOG4105KVH Transcriptional regulator KD35_18135 ENOG4105JAB phenazine biosynthesis protein, phzf family KD35_18145 ENOG4105CHR reductase KD35_18165 ENOG4105KVH Transcriptional regulator KD35_18235 ENOG4105KAF membrAne KD35_18260 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) KD35_18275 ENOG4107YXZ hydrolase, family 25 KD35_18300 ENOG4105ED2 Beta-lactamase KD35_18310 ENOG4105H3G oxidoreductase KD35_18345 ENOG4105CIS alcohol dehydrogenase KD35_18385 ENOG4108TN2 lmbE family KD35_18395 ENOG4107R3E Citrate transporter KD35_18415 ENOG4108MES Periplasmic binding protein KD35_18425 ENOG4105EHG Permease protein KD35_18430 ENOG4105DQ5 transport system permease protein KD35_18435 ENOG4105NX3 Membrane KD35_18440 ENOG4107ZY0 Phenazine biosynthesis-like protein KD35_18460 ENOG4107CUJ Protein of unknown function (DUF2690) KD35_18470 ENOG4107V2S Transcriptional regulator KD35_18490 ENOG4105C98 muts2 protein KD35_18500 ENOG4105E5K Alpha-amylase KD35_18505 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase KD35_18515 ENOG4108A04 Beta-lactamase KD35_18545 ENOG4107VXM glycerophosphoryl diester phosphodiesterase KD35_18570 ENOG41082BM Transcriptional regulator, arsr family KD35_18575 ENOG4105CIS alcohol dehydrogenase KD35_18600 ENOG4105RHY Pfam:UPF0157 KD35_18610 ENOG4105C09 Bile acid KD35_18615 ENOG4105CQB FAD linked oxidase domain protein KD35_18640 ENOG4108UT6 Transferase hexapeptide repeat containing protein KD35_18650 ENOG4105K64 Glycosyl transferase, family 2 KD35_18655 ENOG4105E39 Enoyl-CoA hydratase KD35_18665 ENOG4105KT7 mgtC SapB transporter KD35_18675 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_18680 ENOG41073R8 VanW family KD35_18690 ENOG4108R1P KD35_18710 ENOG4105VEQ Cold shock protein KD35_18730 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) KD35_18750 ENOG410904N short-chain dehydrogenase reductase KD35_18760 ENOG4106IQC argininosuccinate lyase KD35_18775 ENOG4108IA2 Sodium pantothenate symporter KD35_18785 ENOG4105C26 Dehydrogenase KD35_18790 ENOG4105CHR reductase KD35_18800 ENOG4105EWU Squalene--hopene cyclase KD35_18810 ENOG4105FR1 rard protein KD35_18815 ENOG410696E Membrane KD35_18830 ENOG4105D1F ATP-binding protein KD35_18840 ENOG4108ZAF Molybdopterin KD35_18845 ENOG4105CVM Molybdenum cofactor synthesis domain protein KD35_18850 ENOG4105D06 uba thif-type nad fad binding protein KD35_18855 ENOG4105TMB Formate nitrite transporter KD35_18865 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) KD35_18870 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) KD35_18880 ENOG4108JB9 formate dehydrogenase KD35_18890 ENOG4105E1K spore germination protein KD35_18950 ENOG4107QJT sodium dicarboxylate symporter KD35_18955 ENOG4108KGH TRANSCRIPTIONal KD35_18965 ENOG4105EMN RNA polymerase sigma factor KD35_18990 ENOG4105CIG ABC transporter KD35_19000 ENOG4105D9R oxidoreductase KD35_19010 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) KD35_19020 ENOG4105K4P CoA-binding domain protein KD35_19025 ENOG4105C0H protease KD35_19030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_19040 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase KD35_19045 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) KD35_19050 ENOG4105W8X HesB YadR YfhF-family protein KD35_19080 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KD35_19085 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen KD35_19095 ENOG4108JJA ABC, transporter KD35_19100 ENOG4108I0Z Aconitate hydratase KD35_19130 ENOG4105E5W Transporter KD35_19140 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KD35_19160 ENOG4107F3J Amp-dependent synthetase and ligase KD35_19165 ENOG4107ZYJ bioY protein KD35_19170 ENOG4105CEY Amp-dependent synthetase and ligase KD35_19215 ENOG4107AYK membrAne KD35_19225 ENOG4105BZU Histidine kinase KD35_19230 ENOG4105FBA Phospholipase Carboxylesterase KD35_19235 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase KD35_19240 ENOG4105CK7 Sodium proline symporter KD35_19245 ENOG4105CBC glutamate synthase KD35_19250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase KD35_19255 ENOG4108VJ1 Transcriptional regulator (CarD family KD35_19260 ENOG4108903 Formimidoylglutamase KD35_19285 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) KD35_19345 ENOG4107QIV Cytochrome c biogenesis protein KD35_19355 ENOG4107RSM transcriptional regulator KD35_19360 ENOG4105VAW lrga family KD35_19365 ENOG41067MG lrgb family KD35_19390 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase KD35_19405 ENOG4105BZ1 (ABC) transporter KD35_19410 ENOG4105BZ1 (ABC) transporter KD35_19430 ENOG4105D7V transposase KD35_19450 ENOG4105D5T phosphonate abc transporter KD35_19465 ENOG4105CGH 5'-nucleotidase KD35_19475 ENOG4108SVB resolvase KD35_19495 ENOG4105K7K Transcriptional regulator KD35_19530 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase KD35_19535 ENOG4105XSJ toxin secretion phage lysis holin KD35_19740 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) KD35_19845 ENOG4105C5F glutamine synthetase KD35_19850 ENOG4105KV4 Transcriptional regulator KD35_19855 ENOG4105CXI aluminum resistance protein KD35_19865 ENOG4105EN6 Membrane KD35_19870 ENOG4106F1P AAA ATPase, central domain protein KD35_19900 ENOG41069ER domain protein KD35_19905 ENOG4105DM4 PTS System KD35_19910 ENOG4105DE4 1-phosphofructokinase KD35_19915 ENOG4105E98 transcriptional regulator DeoR family KD35_19925 ENOG4108SJC Membrane KD35_19940 ENOG4105C85 amino acid KD35_19955 ENOG4105TMB Formate nitrite transporter KD35_19960 ENOG4105K70 DNA-binding protein KD35_19965 ENOG4105C59 p-type ATPase KD35_19970 ENOG410681U heavy metal transport detoxification protein KD35_19975 ENOG4105VPX protein, conserved in bacteria KD35_19985 ENOG4105NIV Esterase KD35_19990 ENOG4105E0A ABC, transporter KD35_20015 ENOG4105CGK Exodeoxyribonuclease III KD35_20025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) KD35_20030 ENOG4105D03 DNA-3-methyladenine glycosylase II KD35_20060 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_20065 ENOG4105BZU Histidine kinase KD35_20085 ENOG41067MG lrgb family KD35_20100 ENOG4107TTQ Alpha beta hydrolase fold KD35_20105 ENOG4107YEI lmbE family KD35_20125 ENOG4105F0V Cell wall hydrolase KD35_20130 ENOG4107R6R udp-galactopyranose mutase KD35_20135 ENOG4105E0M Sulfatase KD35_20140 ENOG410890F Dynamin family KD35_20150 ENOG4107QHE Choloylglycine hydrolase KD35_20175 ENOG4105DA5 (ABC) transporter KD35_20200 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KD35_20205 ENOG4105DQU oxidoreductase, subunit beta KD35_20210 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein KD35_20215 ENOG4108IGT Dipeptidase KD35_20220 ENOG4105MCT stage V sporulation protein S KD35_20225 ENOG4105D48 metallophosphoesterase KD35_20250 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase KD35_20265 ENOG4105XZV Protein of unknown function (DUF3243) KD35_20270 ENOG4108RKS Short-chain dehydrogenase reductase Sdr KD35_20290 ENOG4105UIB (ABC) transporter KD35_20295 ENOG4105UIB (ABC) transporter KD35_20300 ENOG4108JQ9 ABC transporter KD35_20305 ENOG4105DIH basic membrane KD35_20310 ENOG4105FDP GntR family transcriptional regulator KD35_20315 ENOG4107QZI cell division protein FtsK KD35_20325 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit KD35_20340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) KD35_20350 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) KD35_20355 ENOG4108S0H Dipicolinic acid synthetase, b subunit KD35_20360 ENOG4105E35 Dipicolinate synthase subunit A KD35_20370 ENOG4105C1V Peptidase, M16 KD35_20390 ENOG4105DTN riboflavin biosynthesis protein ribF KD35_20395 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) KD35_20405 ENOG4105W7A Protein of unknown function (DUF503) KD35_20415 ENOG4105VHM ribosomal protein KD35_20420 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination KD35_20425 ENOG4105CHV Transcription elongation factor NusA KD35_20435 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) KD35_20445 ENOG4105DZP Membrane-associated zinc metalloprotease KD35_20450 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) KD35_20455 ENOG4105KNE Phosphatidate cytidylyltransferase KD35_20460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) KD35_20500 ENOG4108HE4 integrase family KD35_20510 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KD35_20520 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha KD35_20535 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) KD35_20560 ENOG4105VB6 UPF0109 protein KD35_20580 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) KD35_20585 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) KD35_20600 ENOG4105CHR reductase KD35_20605 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase KD35_20620 ENOG4105CB5 ATP-dependent DNA helicase recG KD35_20625 ENOG4105DP4 dak2 domain fusion protein ylov KD35_20630 ENOG4108ZAA Alkaline-shock protein KD35_20645 ENOG4105FJ0 thiamine KD35_20650 ENOG4105DJV ribulose-phosphate 3-epimerase KD35_20655 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) KD35_20660 ENOG4105D9P serine threonine protein kinase KD35_20665 ENOG4108ZF3 Phosphatase KD35_20675 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B KD35_20685 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KD35_20690 ENOG4105C25 Primosomal protein n' KD35_20695 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase KD35_20715 ENOG4105DSJ YicC domain protein KD35_20725 ENOG4105F23 Fibronectin-binding protein KD35_20730 ENOG4105DC7 peptidase M24 KD35_20785 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain KD35_20810 ENOG4105C34 Pseudouridine synthase KD35_20825 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) KD35_20835 ENOG4105DBK s4 domain protein KD35_20840 ENOG41067XK integral membrane protein KD35_20850 ENOG4105DFA alanine racemase domain protein KD35_20855 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase KD35_20860 ENOG4105WR5 sporulation protein, YlmC YmxH family KD35_20870 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_20880 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) KD35_20885 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) KD35_20890 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) KD35_20895 ENOG4105D4A Cell wall formation (By similarity) KD35_20900 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KD35_20905 ENOG4105CNI cell division protein FtsW KD35_20920 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) KD35_20925 ENOG4105CJN penicillin-binding protein KD35_20930 ENOG4105CJN penicillin-binding protein KD35_20935 ENOG41068DC Essential cell division protein (By similarity) KD35_20970 ENOG4105KNH Nucleic acid-binding protein KD35_21020 ENOG4105XSJ toxin secretion phage lysis holin KD35_21105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KD35_21115 ENOG4105CAR Terminase, large subunit KD35_21210 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) KD35_21220 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_21275 ENOG4108IMY Transcriptional regulator KD35_21300 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) KD35_21310 ENOG41063PX domain protein KD35_21315 ENOG4105D78 K07001 NTE family protein KD35_21320 ENOG4105H20 Sporulation integral membrane protein YlbJ KD35_21330 ENOG4106H78 methyltransferase KD35_21350 ENOG4107TB6 phosphoglycerate mutase KD35_21365 ENOG4106UY4 Inherit from COG: Scp-like extracellular KD35_21415 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) KD35_21420 ENOG4105CNI cell division protein FtsW KD35_21435 ENOG4108IAB Phoh family KD35_21455 ENOG4105QA2 KD35_21460 ENOG4105CI3 gtp-binding protein typa KD35_21470 ENOG4105ECY inositol monophosphatase KD35_21490 ENOG4105CXN decarboxylase KD35_21535 ENOG4105C7S Dehydrogenase KD35_21540 ENOG4105CPP Dehydrogenase, E1 component KD35_21555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) KD35_21560 ENOG4108X4Q Hydrolase KD35_21570 ENOG4105CN5 Metallo-Beta-Lactamase KD35_21575 ENOG4107ZYR domain protein KD35_21610 ENOG4108XRC Protein of unknown function (DUF458) KD35_21620 ENOG4107IN1 Protein of unknown function (DUF1797) KD35_21635 ENOG4105EPM Diguanylate phosphodiesterase KD35_21640 ENOG4105K6S Short-chain dehydrogenase reductase Sdr KD35_21655 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) KD35_21665 ENOG4105UIN KD35_21730 ENOG4108HGU Histidine kinase KD35_21740 ENOG4105CHM Aminotransferase KD35_21745 ENOG4105FKQ transcriptional regulator KD35_21750 ENOG4105EG2 ABC transporter, permease KD35_21760 ENOG4107FKK extracellular solute-binding protein family 1 KD35_21770 ENOG4105CG3 alpha amylase, catalytic region KD35_21815 ENOG4105CHU acetyl-coa acetyltransferase KD35_21855 ENOG4105K7K Transcriptional regulator KD35_21860 ENOG4105DTD Dehydrogenase KD35_21870 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) KD35_21880 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase KD35_21905 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) KD35_21925 ENOG4106TD9 Diguanylate cyclase KD35_21945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) KD35_21960 ENOG4105CID antiterminator KD35_21970 ENOG4105FDP GntR family transcriptional regulator KD35_21980 ENOG4105CE4 GlcNAc 6-P deacetylase KD35_22025 ENOG4107ZE5 PPIases accelerate the folding of proteins KD35_22030 ENOG4105PTM secreted protein KD35_22035 ENOG4105J7I hydrolase KD35_22045 ENOG4105G6R Stage v sporulation protein ae KD35_22055 ENOG4105CZ3 stage V sporulation protein ad KD35_22060 ENOG41090VF Stage v sporulation protein ac KD35_22080 ENOG4105C8J )-transporter KD35_22085 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_22095 ENOG41082AN stage II sporulation protein KD35_22100 ENOG4105DZ1 carboxypeptidase KD35_22105 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KD35_22110 ENOG4105DVE abc transporter atp-binding protein KD35_22145 ENOG4105D7N magnesium and cobalt transport protein CorA KD35_22170 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KD35_22180 ENOG4105I3K Ferric uptake regulator, Fur family KD35_22185 ENOG4105MZ9 stage II sporulation protein m KD35_22205 ENOG4105CPC Aldo Keto reductase KD35_22215 ENOG4105RHY Pfam:UPF0157 KD35_22235 ENOG4107SKW Inherit from COG: Alpha beta hydrolase KD35_22245 ENOG4105ETE Transcriptional regulator (LacI family KD35_22250 ENOG4108YM7 Gcn5-related n-acetyltransferase KD35_22270 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) KD35_22275 ENOG4108R6K riboflavin synthase, subunit alpha KD35_22295 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) KD35_22300 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) KD35_22305 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) KD35_22310 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) KD35_22320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) KD35_22330 ENOG4105DFD Na H antiporter KD35_22335 ENOG4105CGH 5'-nucleotidase KD35_22375 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) KD35_22390 ENOG4108IXY short-chain dehydrogenase reductase KD35_22395 ENOG41069FQ Metallo-beta-lactamase superfamily KD35_22405 ENOG4105II7 pyrroline-5-carboxylate reductase KD35_22410 ENOG4105EJQ L-serine dehydratase KD35_22435 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KD35_22445 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) KD35_22450 ENOG4105D9U N-acetyltransferase KD35_22465 ENOG4108VZI ErfK ybiS ycfS ynhG family protein KD35_22470 ENOG4108QEG Membrane KD35_22475 ENOG4105CDA abc transporter atp-binding protein KD35_22480 ENOG4105E5Q amino acid AbC transporter KD35_22485 ENOG4108HW3 (ABC) transporter KD35_22500 ENOG4105G7B Protein of unknown function (DUF2992) KD35_22520 ENOG4105C7S Dehydrogenase KD35_22525 ENOG4105CPP Dehydrogenase, E1 component KD35_22545 ENOG4107RDP Dehydrogenase KD35_22560 ENOG4108JUB Transcriptional regulator KD35_22570 ENOG4108QXE glycerophosphoryl diester phosphodiesterase KD35_22585 ENOG4107QQR Sporulation KD35_22590 ENOG4105S1Z Stage IV sporulation protein B KD35_22595 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) KD35_22605 ENOG4105DX0 Hemolysin A KD35_22615 ENOG4105CTB Polyprenyl synthetase KD35_22640 ENOG4108ZSR alkaline shock protein KD35_22645 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase KD35_22670 ENOG410644B Stage III sporulation protein af KD35_22680 ENOG4105KQ4 Stage iii sporulation protein ad KD35_22685 ENOG4108CQH stage III sporulation protein AC KD35_22690 ENOG4105KR5 Stage iii sporulation protein KD35_22695 ENOG4105CD2 stage iii sporulation protein aa KD35_22720 ENOG4105DC7 peptidase M24 KD35_22735 ENOG4105CBJ Metal-dependent enzyme KD35_22745 ENOG4107YBY Hydrolase KD35_22765 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) KD35_22770 ENOG4105WZW rhodanese family KD35_22790 ENOG41080TC multidrug resistance protein KD35_22830 ENOG4105CJ1 ABC, transporter KD35_22835 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family KD35_22865 ENOG4105C0D helicase KD35_22985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) KD35_22990 ENOG4105C3R Methionine synthase KD35_23005 ENOG4105C28 cystathionine KD35_23010 ENOG4105C28 cystathionine KD35_23035 ENOG4105C5X domain protein KD35_23045 ENOG4105DKQ ROK family KD35_23055 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase KD35_23070 ENOG4108UTW Plays a role in the regulation of phosphate uptake KD35_23075 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) KD35_23080 ENOG4105E2Z phosphate ABC transporter (Permease KD35_23085 ENOG4105C8U phosphate abc transporter KD35_23090 ENOG4105PWN phosphate abc transporter KD35_23095 ENOG4107RF6 penicillin-binding protein KD35_23105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) KD35_23130 ENOG4105N80 Ferric uptake regulator, Fur family KD35_23140 ENOG4105FDK ABC transporter KD35_23145 ENOG4108JYZ YitT family KD35_23150 ENOG41069ZM Protein of unknown function (DUF2624) KD35_23175 ENOG4105EGD dinuclear metal center protein, YbgI family KD35_23190 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_23195 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) KD35_23230 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) KD35_23235 ENOG4105KG3 cytidine deaminase KD35_23240 ENOG4107YR5 Diacylglycerol kinase KD35_23250 ENOG4105CTJ Metal Dependent Phosphohydrolase KD35_23255 ENOG4105C9A Phoh family KD35_23270 ENOG41068P3 sporulation protein YqfC KD35_23275 ENOG4105KTH gatB Yqey KD35_23285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) KD35_23290 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) KD35_23310 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ KD35_23320 ENOG4105CSA Coproporphyrinogen iii oxidase KD35_23325 ENOG4105KVH Transcriptional regulator KD35_23350 ENOG4105TQK DNA polymerase iii, delta' subunit KD35_23360 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 KD35_23365 ENOG4108UK2 deaminase KD35_23370 ENOG4105KQC Competence protein KD35_23380 ENOG4105DXX methyltransferase KD35_23390 ENOG4108WF2 Metal Dependent Phosphohydrolase KD35_23400 ENOG410812S Rna-binding protein KD35_23410 ENOG4105CQW ribosome biogenesis GTPase YqeH KD35_23415 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase KD35_23430 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_23450 ENOG4108TVJ Nitroreductase KD35_23465 ENOG4105G6Z alkaline phosphatase KD35_23475 ENOG4108MUZ hydrolase KD35_23510 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin KD35_23515 ENOG4105MIR Phenylalanine 4-monooxygenase KD35_23525 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_23530 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_23570 ENOG4105S6R Iron-hydroxamate transporter permease subunit KD35_23575 ENOG4108V5C ABC transporter KD35_23585 ENOG4108EKI Dehydrogenase KD35_23590 ENOG4105C28 cystathionine KD35_23620 ENOG4107XRG penicillin-binding protein KD35_23635 ENOG4105CFP Peptidase U32 KD35_23640 ENOG4105XYU peptidase (U32 family) KD35_23645 ENOG4108VQJ O-methyltransferase KD35_23650 ENOG4105HHA aminodeoxychorismate lyase KD35_23670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) KD35_23680 ENOG4105C02 permease KD35_23695 ENOG41060CR KD35_23700 ENOG4105C7H Helicase, RecD TraA family KD35_23710 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) KD35_23715 ENOG4105C3J Cysteine desulfurase KD35_23725 ENOG4105D1H recombination factor protein RarA KD35_23730 ENOG4108VCI transcription factor, rsfa family KD35_23735 ENOG4105CUZ uba thif-type nad fad binding protein KD35_23745 ENOG4105CUT histidyl-tRNA synthetase KD35_23760 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) KD35_23770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) KD35_23775 ENOG41076HS cation diffusion facilitator family transporter KD35_23780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) KD35_23790 ENOG4105CKP Polysaccharide Biosynthesis Protein KD35_23795 ENOG4108QG2 Membrane KD35_23805 ENOG4105VIE preprotein translocase, subunit YajC KD35_23820 ENOG41061AI Protein of unknown function (DUF2905) KD35_23835 ENOG4108HUF Transporter KD35_23845 ENOG4108IPJ Membrane KD35_23850 ENOG4108IPJ Membrane KD35_23855 ENOG41082BM Transcriptional regulator, arsr family KD35_23880 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase KD35_23885 ENOG4108IYU L-aspartate oxidase KD35_23900 ENOG4108RPX mosc domain containing protein KD35_23905 ENOG4105CQC Prephenate dehydratase KD35_23925 ENOG4105EWM Histidine kinase KD35_23940 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control KD35_23955 ENOG4105X36 (ribosomal) protein KD35_23965 ENOG4105C03 ribonuclease KD35_23980 ENOG4107QMS site-determining protein KD35_23995 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) KD35_24000 ENOG4105DFF Rod shape-determining protein mreb KD35_24020 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase KD35_24025 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) KD35_24035 ENOG41068KH stage VI sporulation protein D KD35_24045 ENOG4105D52 delta-aminolevulinic acid dehydratase KD35_24070 ENOG4105K56 Transcriptional regulator KD35_24090 ENOG4108IUQ atp-dependent protease KD35_24120 ENOG4108QCI YvbH-like oligomerisation region KD35_24140 ENOG4105M59 Phosphodiesterase, mj0936 family KD35_24145 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) KD35_24155 ENOG4108XJQ germination protein KD35_24165 ENOG4108PCX Major Facilitator KD35_24175 ENOG4105KBX Transcriptional regulator, TetR family KD35_24190 ENOG4105PFC Transcriptional regulator KD35_24205 ENOG4105DZC cytosine deaminase KD35_24210 ENOG4105DZC cytosine deaminase KD35_24215 ENOG4105DEF Extracellular solute-binding protein, family 5 KD35_24220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component KD35_24235 ENOG4108JQ7 (ABC) transporter KD35_24240 ENOG4108HRK Histidine kinase KD35_24245 ENOG4105DY9 regulatoR KD35_24260 ENOG41067S9 phage shock protein C, PspC KD35_24265 ENOG4108JCI Transcriptional regulator KD35_24275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) KD35_24280 ENOG4108Z40 Transcriptional regulator KD35_24285 ENOG4105RHA ABC transporter, permease KD35_24290 ENOG4108IUX (ABC) transporter KD35_24295 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family KD35_24305 ENOG4105E14 MotA TolQ exbB proton channel KD35_24310 ENOG4108VXD carboxy-peptidase KD35_24320 ENOG4105E33 succinate dehydrogenase KD35_24330 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit KD35_24345 ENOG4105K63 Thioredoxin KD35_24350 ENOG4105C10 Electron transfer flavoprotein KD35_24355 ENOG4105BZJ Electron transfer flavoprotein KD35_24360 ENOG41060WC Enoyl-CoA hydratase KD35_24365 ENOG4107Z3H Transcriptional regulator, TetR family KD35_24370 ENOG4105CEY Amp-dependent synthetase and ligase KD35_24380 ENOG4105J76 Periplasmic binding protein KD35_24385 ENOG4105S6R Iron-hydroxamate transporter permease subunit KD35_24430 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_24445 ENOG4105DR4 Methyltransferase KD35_24460 ENOG4105KFN sortase, SrtB family KD35_24465 ENOG4105E0A ABC, transporter KD35_24480 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) KD35_24490 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) KD35_24500 ENOG4105FE9 pseudouridine synthase KD35_24515 ENOG4105DCG PHP domain protein KD35_24550 ENOG4105C5S asparaginyl-tRNA synthetase KD35_24555 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) KD35_24565 ENOG4108RWN rrna methyltransferase KD35_24600 ENOG4105C0R drug resistance transporter emrb qaca subfamily KD35_24605 ENOG4105CW7 secretion protein, HlyD family KD35_24610 ENOG4108JGH Tetr family transcriptional regulator KD35_24615 ENOG4105CN9 Peptidase m42 family protein KD35_24635 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) KD35_24640 ENOG4105C22 threonyL-tRNA synthetase KD35_24645 ENOG4108TDW sporulation protein YtxC KD35_24665 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KD35_24670 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase KD35_24675 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) KD35_24685 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) KD35_24690 ENOG4105C2M dna polymerase I KD35_24695 ENOG4105BZU Histidine kinase KD35_24700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_24720 ENOG4108HMX isocitrate dehydrogenase (NADP) KD35_24725 ENOG4105BZN citrate synthase KD35_24740 ENOG4108REF Sporulation integral membrane protein ytvi KD35_24745 ENOG4105FS0 cytoplasmic membrane protein KD35_24770 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family KD35_24775 ENOG4105C6K Malic enzyme KD35_24780 ENOG4105C0B DNA polymerase III (alpha subunit) KD35_24785 ENOG4105VV2 KD35_24795 ENOG4105SFS phosphoesterase RecJ domain protein KD35_24830 ENOG4105DC7 peptidase M24 KD35_24865 ENOG4105Z7P Acetyltransferase (GNAT) family KD35_24870 ENOG41082W1 Cupin 2, conserved barrel domain protein KD35_24880 ENOG4105VZ8 Transcriptional regulator KD35_24900 ENOG4107YZX Universal stress protein KD35_24940 ENOG4108JYZ YitT family KD35_24960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) KD35_24970 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) KD35_24975 ENOG4105KBJ sporulation protein ytfj KD35_24990 ENOG4105EFZ amidohydrolase KD35_25000 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) KD35_25025 ENOG4106KR7 LysR family Transcriptional regulator KD35_25045 ENOG4105C28 cystathionine KD35_25065 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KD35_25075 ENOG4105EMN RNA polymerase sigma factor KD35_25090 ENOG4105F1V Acetoin utilization protein KD35_25095 ENOG4105W87 Cbs domain KD35_25100 ENOG4105DGU Histone deacetylase KD35_25110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family KD35_25120 ENOG4107SNB ankyrin repeat protein YahD KD35_25125 ENOG4105EP9 oxidoreductase KD35_25155 ENOG4105ETE Transcriptional regulator (LacI family KD35_25180 ENOG4105C88 aminopeptidase KD35_25225 ENOG4108VDD TRNA binding domain protein KD35_25255 ENOG4105C8F Beta-lactamase domain protein KD35_25270 ENOG4108V15 phosphotransferase enzyme family KD35_25275 ENOG4108IUM Glycogen debranching enzyme KD35_25290 ENOG4107QSE Dipeptidase KD35_25295 ENOG4107QSE Dipeptidase KD35_25300 ENOG4105YW5 deoR family transcriptional regulator KD35_25315 ENOG4105CBX hi0933 family KD35_25350 ENOG4108VJ1 Transcriptional regulator (CarD family KD35_25355 ENOG4107EXU Short-chain dehydrogenase reductase Sdr KD35_25360 ENOG4105CSC Glucose uptake protein KD35_25375 ENOG4108ZAF Molybdopterin KD35_25380 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein KD35_25385 ENOG4105CVM Molybdenum cofactor synthesis domain protein KD35_25395 ENOG4105D06 uba thif-type nad fad binding protein KD35_25420 ENOG41085GJ domain protein KD35_25430 ENOG4105DWV Homoserine O-trans-acetylase KD35_25440 ENOG4108B31 Spore germination protein KD35_25475 ENOG410605W Major Facilitator KD35_25480 ENOG4107S91 Sodium hydrogen exchanger KD35_25485 ENOG4105NCW Trka-c domain protein KD35_25500 ENOG4105C19 ABC transporter KD35_25520 ENOG4105N5T Radical SAM Protein KD35_25530 ENOG4105DA5 (ABC) transporter KD35_25560 ENOG4105E8V Alpha Beta Hydrolase Fold protein KD35_25565 ENOG4108Z0R Transferase KD35_25570 ENOG4105YVM Phosphoesterase, PA-phosphatase related KD35_25575 ENOG4105BZF Glycosyl transferase (Group 1 KD35_25585 ENOG4108RIR Molybdenum cofactor biosynthesis protein KD35_25640 ENOG4105EGD dinuclear metal center protein, YbgI family KD35_25645 ENOG4105BZU Histidine kinase KD35_25650 ENOG4105BZU Histidine kinase KD35_25655 ENOG4107S9D Alpha beta hydrolase KD35_25675 ENOG4105D2X ABC transporter substrate-binding protein KD35_25685 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component KD35_25740 ENOG4108V2W Carbonate dehydratase KD35_25745 ENOG4105C4M (Ubiquinol oxidase) subunit I KD35_25750 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii KD35_25795 ENOG41087YS Phage shock protein A KD35_25830 ENOG4105BZU Histidine kinase KD35_25835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_25860 ENOG4108UGV hypoxanthine phosphoribosyltransferase KD35_25865 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) KD35_25900 ENOG4107ZTW SNARE associated Golgi KD35_25915 ENOG4105C19 ABC transporter KD35_25920 ENOG41086D8 Transcriptional regulator KD35_25970 ENOG4105C6Z Gluconate KD35_25975 ENOG4105FDP GntR family transcriptional regulator KD35_25995 ENOG41069H0 dihydroorotase EC 3.5.2.3 KD35_26025 ENOG4105DTQ mandelate racemase muconate lactonizing KD35_26035 ENOG4108IPT Naphthoate synthase KD35_26040 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) KD35_26045 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) KD35_26050 ENOG4105E4F Isochorismate synthase KD35_26055 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase KD35_26065 ENOG4105VEQ Cold shock protein KD35_26090 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) KD35_26100 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) KD35_26110 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KD35_26205 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation KD35_26240 ENOG4105KT7 mgtC SapB transporter KD35_26245 ENOG4107PBV potassium channel KD35_26255 ENOG4107QYV phosphohexose isomerase KD35_26265 ENOG4105WG9 Conserved Protein KD35_26275 ENOG4105CHM Aminotransferase KD35_26280 ENOG4108ZB6 transcriptional regulator AsnC family KD35_26285 ENOG4105C5I Dehydrogenase KD35_26290 ENOG4108MUZ hydrolase KD35_26300 ENOG4105C87 Aminotransferase class I and II KD35_26315 ENOG4105Y38 Kinase-associated protein B KD35_26325 ENOG4107R3E Citrate transporter KD35_26340 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) KD35_26345 ENOG4105KA0 thioesterase Superfamily protein KD35_26365 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KD35_26385 ENOG41069ER domain protein KD35_26400 ENOG4105CEP NADH dehydrogenase KD35_26430 ENOG4105EWC Purine nucleoside phosphorylase KD35_26450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA KD35_26475 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) KD35_26480 ENOG4105C4B ABC transporter, permease KD35_26485 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA KD35_26530 ENOG41083MR nifu domain-containing protein KD35_26545 ENOG4108W5N phosphatidylglycerophosphatase a KD35_26560 ENOG4105DYS nad(p)h dehydrogenase (quinone) KD35_26565 ENOG4105D4U had-superfamily hydrolase, subfamily iia KD35_26580 ENOG4105CBT Fructose-1,6-bisphosphatase KD35_26600 ENOG4105MMD transcriptional regulator KD35_26605 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) KD35_26610 ENOG4107TXC Transcriptional regulator KD35_26615 ENOG41090T1 Membrane KD35_26640 ENOG4105FAA peptidase M23 KD35_26650 ENOG4105KZD Domain of unknown function (DUF1805) KD35_26655 ENOG4107R8B 5'-nucleotidase KD35_26680 ENOG4105DIW FeS assembly protein SUFB KD35_26685 ENOG4108UNV SUF system FeS assembly protein, NifU family KD35_26690 ENOG4105C9B Cysteine desulfurase KD35_26695 ENOG4105JRK feS assembly protein SufD KD35_26700 ENOG4105C3K feS assembly ATPase SufC KD35_26705 ENOG4105D01 (LipO)protein KD35_26710 ENOG4105D01 (LipO)protein KD35_26715 ENOG4108UMI ABC transporter, permease KD35_26750 ENOG41080E8 Transcriptional regulator, Spx MgsR family KD35_26800 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) KD35_26830 ENOG4108W8B Beta-lactamase domain protein KD35_26835 ENOG4105C1G acyl-Coa dehydrogenase KD35_26845 ENOG4105CHU acetyl-coa acetyltransferase KD35_26860 ENOG4105DZ1 carboxypeptidase KD35_26880 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer KD35_26900 ENOG4108SUT Major Facilitator Superfamily KD35_26905 ENOG4107R7I amino acid KD35_26915 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins KD35_26925 ENOG4107AYK membrAne KD35_26960 ENOG4107ZTW SNARE associated Golgi KD35_26970 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein KD35_26975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family KD35_26980 ENOG4105BZU Histidine kinase KD35_26990 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) KD35_27005 ENOG4105VG1 fes assembly suf system protein KD35_27010 ENOG4105D4Y metalloprotease KD35_27030 ENOG4107S91 Sodium hydrogen exchanger KD35_27035 ENOG4105NCW Trka-c domain protein KD35_27050 ENOG4108RMU ferritin dps family protein KD35_27065 ENOG4108URH decarboxylase KD35_27090 ENOG4105D9N nucleoside KD35_27095 ENOG4105D9N nucleoside KD35_27110 ENOG4108RYK Nad-dependent epimerase dehydratase KD35_27125 ENOG4105CV8 reductase KD35_27130 ENOG4105F27 Major Facilitator KD35_27135 ENOG4105KVH Transcriptional regulator KD35_27150 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) KD35_27155 ENOG4105D4A Cell wall formation (By similarity) KD35_27165 ENOG4105C8Q Methyl-accepting chemotaxis KD35_27175 ENOG4105WMR Protein CrcB homolog KD35_27180 ENOG4105WMR Protein CrcB homolog KD35_27195 ENOG4108MK9 spermidine N(1)-acetyltransferase KD35_27200 ENOG4108VY7 phosphate-starvation-inducible protein PsiE KD35_27215 ENOG4108IPW abc transporter atp-binding protein KD35_27220 ENOG4105CM4 permease protein KD35_27245 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) KD35_27255 ENOG4105XZU Preprotein translocase, subunit SecG KD35_27260 ENOG41067MG lrgb family KD35_27360 ENOG4105EFC phage portal protein HK97 family KD35_27385 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KD35_27395 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) KD35_27400 ENOG4105CP7 Triose-phosphate isomerase KD35_27425 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) KD35_27445 ENOG41090VF Stage v sporulation protein ac KD35_27450 ENOG4105CZ3 stage V sporulation protein ad KD35_27465 ENOG4105H67 Protein of unknown function (DUF421) KD35_27470 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) KD35_27475 ENOG4105KRI phosphocarrier protein (HPr KD35_27485 ENOG4105CHW UPF0052 protein KD35_27495 ENOG4108Z4K mutator MutT protein KD35_27505 ENOG4105C3M thioredoxin reductase KD35_27515 ENOG4108S4C acetyltransferase KD35_27535 ENOG41086DT Membrane protein of unknown function KD35_27545 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) KD35_27550 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) KD35_27555 ENOG4105D7V transposase KD35_27570 ENOG4107TXC Transcriptional regulator KD35_27595 ENOG4105HMI Membrane KD35_27600 ENOG4105DUM transcriptional regulator, lysR family KD35_27610 ENOG4108WS4 fmn reductase KD35_27625 ENOG4105BZ1 (ABC) transporter KD35_27635 ENOG4105CN1 protease KD35_27640 ENOG4105CRP Part of the ABC transporter FtsEX involved in KD35_27645 ENOG4105CAK Cell division ATP-binding protein ftsE KD35_27660 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) KD35_27665 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving KD35_27670 ENOG4105MS2 ribosomal subunit Interface protein KD35_27675 ENOG4105VEQ Cold shock protein KD35_27680 ENOG41081UC Inherit from COG: Competence protein KD35_27695 ENOG4105KVH Transcriptional regulator KD35_27710 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein KD35_27715 ENOG4108KGH TRANSCRIPTIONal KD35_27720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase KD35_27725 ENOG4105C6Y Udp-glucose 6-dehydrogenase KD35_27730 ENOG4105ESV Glycosyl transferase, family 4 KD35_27740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family KD35_27755 ENOG410901P UPF0249 protein KD35_27760 ENOG4105F8D glycoside hydrolase family 4 KD35_27765 ENOG4105VCP PTS System KD35_27770 ENOG4105CK1 PTS System KD35_27780 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) KD35_27785 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) KD35_27790 ENOG4105VCP PTS System KD35_27800 ENOG4105VZJ PTS System KD35_27815 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase KD35_27820 ENOG4105ECB domain protein KD35_27825 ENOG4107RSM transcriptional regulator KD35_27880 ENOG4105EKQ RNA-directed DNA polymerase KD35_27960 ENOG4105EKQ RNA-directed DNA polymerase KD35_28015 ENOG4106JUT Streptomycin 3''-adenylyltransferase KD35_28080 ENOG4105CNU cell division protein FtsK KD35_28305 ENOG4105DHF Membrane KD35_28330 ENOG4106AKK s-layer domain-containing protein KD35_28335 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase KD35_28360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase KD35_28365 ENOG4105C6Y Udp-glucose 6-dehydrogenase KD35_28380 ENOG4105DQ6 Transposase KD35_28420 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) KD35_28535 ENOG4105KRN Transcriptional regulator, abrb family KD35_28545 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) KD35_28575 ENOG4108IBT Inherit from COG: transposase KD35_28585 ENOG4105DQ6 Transposase KD35_28605 ENOG4108MEK Metal-binding protein YodA KD35_28615 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) KD35_28645 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) KD35_28725 ENOG4105K4H Nlp p60 protein KD35_28870 ENOG4107QJE Chromosome Partitioning Protein KD35_28890 ENOG4105DQ6 Transposase KD35_28915 ENOG4105EWC Purine nucleoside phosphorylase KD35_28990 ENOG4105C3F Signal peptidase i KD35_29020 ENOG4105N14 lysine exporter protein LysE YggA KD35_29055 ENOG4108J59 Extracellular solute-binding protein, family 5 KD35_29070 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) KD35_29130 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) KD35_29135 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)