locus-tag class description BF25_1003 ENOG4105DA5 (ABC) transporter BF25_1008 ENOG4107QHE Choloylglycine hydrolase BF25_101 ENOG4105FS0 cytoplasmic membrane protein BF25_1010 ENOG410890F Dynamin family BF25_1011 ENOG4105E0M Sulfatase BF25_1012 ENOG4107R6R udp-galactopyranose mutase BF25_1013 ENOG4105F0V Cell wall hydrolase BF25_1017 ENOG4107YEI lmbE family BF25_1018 ENOG4107TTQ Alpha beta hydrolase fold BF25_102 ENOG4108REF Sporulation integral membrane protein ytvi BF25_1021 ENOG41067MG lrgb family BF25_1024 ENOG4105BZU Histidine kinase BF25_1025 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_1031 ENOG4105D03 DNA-3-methyladenine glycosylase II BF25_1032 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF25_1034 ENOG4105CGK Exodeoxyribonuclease III BF25_1039 ENOG4105E0A ABC, transporter BF25_104 ENOG4105BZN citrate synthase BF25_1040 ENOG4105NIV Esterase BF25_1042 ENOG4105VPX protein, conserved in bacteria BF25_1043 ENOG410681U heavy metal transport detoxification protein BF25_1044 ENOG4105C59 p-type ATPase BF25_1045 ENOG4105K70 DNA-binding protein BF25_1046 ENOG4105TMB Formate nitrite transporter BF25_105 ENOG4108HMX isocitrate dehydrogenase (NADP) BF25_1050 ENOG4105C85 amino acid BF25_1053 ENOG4108SJC Membrane BF25_1054 ENOG4107QW4 alcohol dehydrogenase BF25_1055 ENOG4107QW4 alcohol dehydrogenase BF25_1056 ENOG4105E98 transcriptional regulator DeoR family BF25_1057 ENOG4105DE4 1-phosphofructokinase BF25_1058 ENOG4105DM4 PTS System BF25_1059 ENOG41069ER domain protein BF25_1066 ENOG4106F1P AAA ATPase, central domain protein BF25_1067 ENOG4105EN6 Membrane BF25_1068 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF25_1069 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF25_1070 ENOG4105CXI aluminum resistance protein BF25_1071 ENOG4105KV4 Transcriptional regulator BF25_1072 ENOG4105C5F glutamine synthetase BF25_109 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_1093 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF25_110 ENOG4105BZU Histidine kinase BF25_111 ENOG4105C2M dna polymerase I BF25_112 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF25_1133 ENOG4105XSJ toxin secretion phage lysis holin BF25_1134 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF25_114 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF25_1142 ENOG4105K7K Transcriptional regulator BF25_1146 ENOG4108SVB resolvase BF25_1148 ENOG4105CGH 5'-nucleotidase BF25_115 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF25_1151 ENOG4105D5T phosphonate abc transporter BF25_1154 ENOG4105D7V transposase BF25_1158 ENOG4105BZ1 (ABC) transporter BF25_1159 ENOG4105BZ1 (ABC) transporter BF25_116 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF25_1162 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF25_1167 ENOG41067MG lrgb family BF25_1168 ENOG4105VAW lrga family BF25_1169 ENOG4107RSM transcriptional regulator BF25_1171 ENOG4107QIV Cytochrome c biogenesis protein BF25_1182 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF25_1187 ENOG4108903 Formimidoylglutamase BF25_1188 ENOG4108VJ1 Transcriptional regulator (CarD family BF25_1189 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF25_1190 ENOG4105CBC glutamate synthase BF25_1191 ENOG4105CK7 Sodium proline symporter BF25_1192 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF25_1193 ENOG4105FBA Phospholipase Carboxylesterase BF25_1194 ENOG4105BZU Histidine kinase BF25_1196 ENOG4107AYK membrAne BF25_120 ENOG4108TDW sporulation protein YtxC BF25_1205 ENOG4105CEY Amp-dependent synthetase and ligase BF25_1206 ENOG4107ZYJ bioY protein BF25_1207 ENOG4107F3J Amp-dependent synthetase and ligase BF25_121 ENOG4105C22 threonyL-tRNA synthetase BF25_1211 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_1213 ENOG4105E5W Transporter BF25_1218 ENOG4108I0Z Aconitate hydratase BF25_1219 ENOG4108JJA ABC, transporter BF25_122 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF25_1221 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF25_1222 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF25_1228 ENOG4105W8X HesB YadR YfhF-family protein BF25_1229 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF25_1230 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF25_1232 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_1233 ENOG4105C0H protease BF25_1234 ENOG4105K4P CoA-binding domain protein BF25_1235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF25_1237 ENOG4105D9R oxidoreductase BF25_1239 ENOG4105CIG ABC transporter BF25_1243 ENOG4105EMN RNA polymerase sigma factor BF25_1245 ENOG4108KGH TRANSCRIPTIONal BF25_1259 ENOG4105E1K spore germination protein BF25_126 ENOG4105CN9 Peptidase m42 family protein BF25_1261 ENOG4108JB9 formate dehydrogenase BF25_1263 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF25_1264 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF25_1266 ENOG4105TMB Formate nitrite transporter BF25_1267 ENOG4105D06 uba thif-type nad fad binding protein BF25_1268 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_1269 ENOG4108ZAF Molybdopterin BF25_127 ENOG4108JGH Tetr family transcriptional regulator BF25_1271 ENOG4105D1F ATP-binding protein BF25_1274 ENOG410696E Membrane BF25_1275 ENOG4105FR1 rard protein BF25_1277 ENOG4105EWU Squalene--hopene cyclase BF25_1279 ENOG4105CHR reductase BF25_128 ENOG4105CW7 secretion protein, HlyD family BF25_1280 ENOG4105C26 Dehydrogenase BF25_1282 ENOG4108IA2 Sodium pantothenate symporter BF25_1285 ENOG4106IQC argininosuccinate lyase BF25_1287 ENOG410904N short-chain dehydrogenase reductase BF25_129 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_1291 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF25_1295 ENOG4105VEQ Cold shock protein BF25_1299 ENOG4108R1P BF25_13 ENOG4105C88 aminopeptidase BF25_1301 ENOG41073R8 VanW family BF25_1302 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_1304 ENOG4105KT7 mgtC SapB transporter BF25_1306 ENOG4105E39 Enoyl-CoA hydratase BF25_1307 ENOG4105K64 Glycosyl transferase, family 2 BF25_1309 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF25_1313 ENOG4105CQB FAD linked oxidase domain protein BF25_1314 ENOG4105C09 Bile acid BF25_1316 ENOG4105RHY Pfam:UPF0157 BF25_1322 ENOG4105CIS alcohol dehydrogenase BF25_1323 ENOG41082BM Transcriptional regulator, arsr family BF25_1327 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF25_1333 ENOG4108A04 Beta-lactamase BF25_1334 ENOG4105DPN Oligoendopeptidase f BF25_1335 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF25_1336 ENOG4105E5K Alpha-amylase BF25_1338 ENOG4105C98 muts2 protein BF25_1342 ENOG4107V2S Transcriptional regulator BF25_1344 ENOG4107CUJ Protein of unknown function (DUF2690) BF25_1348 ENOG4107ZY0 Phenazine biosynthesis-like protein BF25_1349 ENOG4105NX3 Membrane BF25_1350 ENOG4105DQ5 transport system permease protein BF25_1351 ENOG4105EHG Permease protein BF25_1353 ENOG4108MES Periplasmic binding protein BF25_1357 ENOG4107R3E Citrate transporter BF25_1359 ENOG4108TN2 lmbE family BF25_136 ENOG4108RWN rrna methyltransferase BF25_1366 ENOG4105CIS alcohol dehydrogenase BF25_1367 ENOG4105CIS alcohol dehydrogenase BF25_1374 ENOG4105H3G oxidoreductase BF25_1376 ENOG4105ED2 Beta-lactamase BF25_138 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF25_1381 ENOG4107YXZ hydrolase, family 25 BF25_1385 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF25_139 ENOG4105C5S asparaginyl-tRNA synthetase BF25_1390 ENOG4105KAF membrAne BF25_1400 ENOG4108ZJ4 polysaccharide deacetylase BF25_1404 ENOG4105KVH Transcriptional regulator BF25_1405 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF25_1409 ENOG4105CHR reductase BF25_1411 ENOG4105JAB phenazine biosynthesis protein, phzf family BF25_1418 ENOG4105KVH Transcriptional regulator BF25_1419 ENOG4105KVH Transcriptional regulator BF25_1420 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF25_1422 ENOG4105D9R oxidoreductase BF25_1423 ENOG4108TZY GntR Family Transcriptional Regulator BF25_1424 ENOG4105KVH Transcriptional regulator BF25_1430 ENOG4105C44 Serine transporter BF25_1431 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF25_1434 ENOG4105F27 Major Facilitator BF25_1435 ENOG4105CV8 reductase BF25_1439 ENOG4105D4Y metalloprotease BF25_1440 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF25_1443 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF25_1444 ENOG4105CIS alcohol dehydrogenase BF25_1445 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF25_1446 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF25_1449 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF25_1450 ENOG4105C6Z Gluconate BF25_1451 ENOG4105CMG Carbohydrate kinase BF25_1452 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF25_1453 ENOG4105XDF Protein of unknown function (DUF1272) BF25_1454 ENOG4105DDN Pentapeptide repeat-containing protein BF25_1457 ENOG4105C37 (CBS) domain BF25_146 ENOG4105DCG PHP domain protein BF25_1463 ENOG4105EV4 Multidrug resistance protein mdtH BF25_1465 ENOG4105DMQ Methyltransferase BF25_1470 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF25_1471 ENOG4105C31 Tryptophanyl-tRNA synthetase BF25_1473 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF25_1476 ENOG4108UW5 maltose o-acetyltransferase BF25_1477 ENOG4106UW1 Major Facilitator superfamily BF25_1478 ENOG4105DKQ ROK family BF25_1479 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_149 ENOG4105FE9 pseudouridine synthase BF25_1491 ENOG4105CJ1 ABC, transporter BF25_1493 ENOG4108PSK reductase BF25_1497 ENOG4108RCM Nitroreductase BF25_1498 ENOG4105KVH Transcriptional regulator BF25_1501 ENOG4105CUT histidyl-tRNA synthetase BF25_1502 ENOG4108Z66 YbaK ebsC protein BF25_1504 ENOG41067QW Transcriptional regulator BF25_1507 ENOG4108K8S endonuclease I BF25_151 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF25_1512 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF25_1513 ENOG4108JJB ABC transporter BF25_1519 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF25_1521 ENOG4105CRW Short chain fatty acid transporter BF25_1523 ENOG4105KBX Transcriptional regulator, TetR family BF25_1524 ENOG4105KPY Small multidrug resistance protein BF25_1525 ENOG4105RXJ BF25_1527 ENOG41069JR BF25_1528 ENOG4105DA5 (ABC) transporter BF25_153 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF25_1532 ENOG4105CZM Major Facilitator BF25_1533 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF25_1535 ENOG4108ISG Major Facilitator BF25_1543 ENOG4105HIR S-layer domain protein BF25_1546 ENOG410874W AraC family transcriptional regulator BF25_1547 ENOG41082W1 Cupin 2, conserved barrel domain protein BF25_1550 ENOG4108AEY RNA polymerase sigma factor BF25_1554 ENOG4108JQ1 Dehydrogenase BF25_1557 ENOG4105DVH amino acid BF25_1559 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF25_156 ENOG4105E0A ABC, transporter BF25_1562 ENOG4108JPW Aminotransferase BF25_1564 ENOG4105EJQ L-serine dehydratase BF25_1565 ENOG4105C44 Serine transporter BF25_1568 ENOG4108JGH Tetr family transcriptional regulator BF25_1569 ENOG4105EQ0 Major Facilitator superfamily BF25_157 ENOG4105KFN sortase, SrtB family BF25_1570 ENOG4105MZU cell filamentation protein BF25_1573 ENOG4107QJQ Mate efflux family protein BF25_1580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_1588 ENOG4105TRI Hydrolase BF25_1594 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF25_1596 ENOG4106P55 Transcriptional regulator BF25_1598 ENOG4107QR9 Iron-sulfur cluster binding protein BF25_1599 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF25_160 ENOG4105DR4 Methyltransferase BF25_1600 ENOG4105DJB Major Facilitator Superfamily BF25_1601 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF25_1603 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF25_1604 ENOG4108U05 Transcriptional regulator BF25_1607 ENOG4105BZU Histidine kinase BF25_1610 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF25_1611 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF25_1614 ENOG4105JQZ Methyltransferase BF25_1615 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_1617 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF25_1618 ENOG4108NNI Beta-lactamase domain-containing protein BF25_1621 ENOG4105VZ8 Transcriptional regulator BF25_1627 ENOG4105K6H D-cysteine desulfhydrase BF25_163 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_1632 ENOG41062D9 Histidine kinase BF25_1633 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_1636 ENOG4105IIP Membrane BF25_1638 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_1639 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF25_1653 ENOG4108YXU transcriptional regulator AsnC family BF25_1654 ENOG4105CHR reductase BF25_1656 ENOG4105F7F Chaperone BF25_1660 ENOG41085FC arsR family transcriptional regulator BF25_1661 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_1662 ENOG4105D6J arsenicaL-resistance protein BF25_1668 ENOG4105DIK (ABC) transporter BF25_1669 ENOG4105CC5 ABC transporter BF25_1670 ENOG4105DSE periplasmic solute binding protein BF25_1671 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF25_1672 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF25_1674 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF25_1675 ENOG4108TWJ NADH dehydrogenase subunit 5 BF25_1678 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF25_1679 ENOG4108606 TspO/MBR family BF25_1687 ENOG41090MY MarR family Transcriptional regulator BF25_1693 ENOG4105CHJ isochorismatase hydrolase BF25_1695 ENOG4105CH6 catalase BF25_1696 ENOG4105CGH 5'-nucleotidase BF25_17 ENOG4105ETE Transcriptional regulator (LacI family BF25_1705 ENOG4105CSV Glutaminase BF25_1712 ENOG4108NHD germination protein BF25_1713 ENOG4108NHD germination protein BF25_1716 ENOG4105C6K Malic enzyme BF25_1718 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_172 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF25_1720 ENOG4105CUB amino acid BF25_1721 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF25_1723 ENOG4108IMY Transcriptional regulator BF25_1724 ENOG4105HDK L-asparaginase BF25_1725 ENOG4108IJ0 Aspartate ammonia-lyase BF25_1728 ENOG4105E2A Dehydrogenase BF25_173 ENOG4105J76 Periplasmic binding protein BF25_1743 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF25_1749 ENOG4105DWD nucleoside recognition domain protein BF25_175 ENOG4105CEY Amp-dependent synthetase and ligase BF25_1753 ENOG4105FDT acyl-CoA dehydrogenase BF25_1755 ENOG4108ZHR arsR family transcriptional regulator BF25_1756 ENOG4108ZRV stage ii sporulation protein p BF25_1757 ENOG4106N3A copper homeostasis protein cutc BF25_1759 ENOG4107258 Transcriptional regulator BF25_176 ENOG4107Z3H Transcriptional regulator, TetR family BF25_1760 ENOG4105P4J Allophanate hydrolase, subunit 1 BF25_1768 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF25_177 ENOG41060WC Enoyl-CoA hydratase BF25_1770 ENOG4107RF6 penicillin-binding protein BF25_1778 ENOG4105F1N DNA alkylation repair BF25_178 ENOG4105BZJ Electron transfer flavoprotein BF25_1780 ENOG4108IQI permease BF25_1781 ENOG4105KNA -acetyltransferase BF25_1782 ENOG410635A Membrane BF25_179 ENOG4105C10 Electron transfer flavoprotein BF25_1798 ENOG4108XET gCN5-related N-acetyltransferase BF25_180 ENOG4105K63 Thioredoxin BF25_1804 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF25_1806 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_1813 ENOG4105FS7 Transcriptional regulator BF25_1814 ENOG4108TVJ Nitroreductase BF25_1816 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_1825 ENOG4105C8Y Acetylornithine aminotransferase BF25_1827 ENOG4105CKK Glycosyl transferase, family 2 BF25_183 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF25_1832 ENOG4105CKK Glycosyl transferase, family 2 BF25_1837 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_1842 ENOG41068WN BF25_1844 ENOG4108WCX response regulator BF25_1846 ENOG41090T1 Membrane BF25_1849 ENOG4105VMP Transcriptional regulator BF25_185 ENOG4105E33 succinate dehydrogenase BF25_1851 ENOG4105G6Z alkaline phosphatase BF25_1852 ENOG4105ECK Fatty Acid Desaturase BF25_1853 ENOG4105E0Y RtcB Protein BF25_1855 ENOG4107258 Transcriptional regulator BF25_1857 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_1858 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF25_1864 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF25_1869 ENOG41061GT Aldolase BF25_187 ENOG4108VXD carboxy-peptidase BF25_1872 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF25_1873 ENOG4105DKT Transcriptional regulator BF25_1875 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF25_1877 ENOG4105D4B ABC, transporter BF25_188 ENOG4105E14 MotA TolQ exbB proton channel BF25_1883 ENOG4105EMN RNA polymerase sigma factor BF25_1885 ENOG41069ER domain protein BF25_189 ENOG4105ER2 Ompa motb domain protein BF25_1893 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF25_1894 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF25_1895 ENOG4105CIH Imidazole acetol-phosphate transaminase BF25_1899 ENOG41082JN Transcriptional regulator BF25_190 ENOG4105ER2 Ompa motb domain protein BF25_1900 ENOG4105EYF MMPL domain protein BF25_1901 ENOG4105EYF MMPL domain protein BF25_1903 ENOG4105C5H ABC transporter BF25_1904 ENOG4105E0M Sulfatase BF25_1905 ENOG4108ZCF integral membrane protein BF25_1907 ENOG4107VMI polysaccharide deacetylase BF25_1909 ENOG4107VC0 DNA alkylation repair enzyme BF25_191 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF25_1919 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF25_192 ENOG4108IUX (ABC) transporter BF25_1923 ENOG4105E09 nadh pyrophosphatase BF25_1928 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF25_1929 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF25_193 ENOG4105RHA ABC transporter, permease BF25_1930 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF25_1932 ENOG4105C02 permease BF25_194 ENOG4108Z40 Transcriptional regulator BF25_1941 ENOG4105DVE abc transporter atp-binding protein BF25_1948 ENOG4105CHM Aminotransferase BF25_195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF25_1954 ENOG41089UC methyltransferase, type 11 BF25_1957 ENOG4107BMA Transglycosylase associated protein BF25_1961 ENOG4106K7D Major facilitator family transporter BF25_1962 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF25_197 ENOG4108JCI Transcriptional regulator BF25_1970 ENOG4105EPR degv family BF25_1973 ENOG4105DPN Oligoendopeptidase f BF25_198 ENOG41067S9 phage shock protein C, PspC BF25_1980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_1981 ENOG4105BZU Histidine kinase BF25_1982 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF25_1990 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_1993 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF25_1994 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF25_1997 ENOG4107T5V SNARE associated Golgi BF25_2004 ENOG41080HI glycine oxidase BF25_2005 ENOG4105CTU Proline racemase BF25_2006 ENOG4105CTU Proline racemase BF25_2007 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF25_2008 ENOG4105C26 Dehydrogenase BF25_2009 ENOG4105BZG amino acid carrier protein BF25_201 ENOG4105DY9 regulatoR BF25_2012 ENOG4108M1A Chitin-binding protein BF25_202 ENOG4108HRK Histidine kinase BF25_2020 ENOG4105C9U ATP-dependent DNA helicase RecQ BF25_2024 ENOG4105EEM helicase BF25_203 ENOG4108JQ7 (ABC) transporter BF25_2035 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF25_2044 ENOG4108M1A Chitin-binding protein BF25_2045 ENOG41082BV acetyltransferase BF25_2046 ENOG4105E66 phosphoriboisomerase A BF25_2051 ENOG4108IJ7 Glycine betaine BF25_2052 ENOG4107SQ8 Glycine betaine BF25_2058 ENOG4105RHY Pfam:UPF0157 BF25_2059 ENOG4105E1F short-chain dehydrogenase reductase BF25_206 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_2061 ENOG4107RUY (E1 component), alpha subunit BF25_2063 ENOG4107QKR Dehydrogenase BF25_2068 ENOG41062ES Transcriptional regulator BF25_207 ENOG4105DEF Extracellular solute-binding protein, family 5 BF25_2072 ENOG4105E98 transcriptional regulator DeoR family BF25_2076 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF25_208 ENOG4105DZC cytosine deaminase BF25_2082 ENOG4107Z3H Transcriptional regulator, TetR family BF25_2083 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF25_2084 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF25_2085 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF25_2089 ENOG4105MSI germination protein ypeb BF25_209 ENOG4105DZC cytosine deaminase BF25_2093 ENOG4108V3A UPF0421 protein BF25_2100 ENOG4105FDR Membrane BF25_2102 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF25_2107 ENOG4108IUM Glycogen debranching enzyme BF25_2111 ENOG4105DY8 decarboxylase BF25_2116 ENOG4105PAD Hydrolase BF25_212 ENOG4105PFC Transcriptional regulator BF25_2121 ENOG4107VFR oxidoreductase BF25_2129 ENOG4105PKS Excinuclease abc c subunit domain protein BF25_2137 ENOG4105KWG Pfam:DUF1696 BF25_2138 ENOG4108NRW Phospholipase, patatin family BF25_2144 ENOG4108XI2 Domain of unknown function (DUF1963) BF25_215 ENOG4105KBX Transcriptional regulator, TetR family BF25_2151 ENOG4108Z4K mutator MutT protein BF25_2152 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF25_2153 ENOG4105E09 nadh pyrophosphatase BF25_2155 ENOG4105FCD Major Facilitator BF25_2162 ENOG4107Y9U Membrane BF25_2167 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF25_217 ENOG4108PCX Major Facilitator BF25_2171 ENOG4107Y80 Major Facilitator superfamily BF25_2176 ENOG4108V4B ThiJ pfpI BF25_2182 ENOG4105FQP Beta-lactamase BF25_2184 ENOG4105CJN penicillin-binding protein BF25_2185 ENOG4105CB2 alcohol dehydrogenase BF25_2188 ENOG4108HGU Histidine kinase BF25_219 ENOG4108XJQ germination protein BF25_2191 ENOG4108JJB ABC transporter BF25_2195 ENOG4107RF6 penicillin-binding protein BF25_2196 ENOG4105BZU Histidine kinase BF25_2198 ENOG410667J hydrolase BF25_221 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF25_222 ENOG4105M59 Phosphodiesterase, mj0936 family BF25_2221 ENOG4105ETU transcriptional activator (TenA BF25_2243 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF25_2244 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF25_2247 ENOG4105CPQ Dehydrogenase BF25_2253 ENOG4105CUV Homoserine Kinase BF25_2257 ENOG4107Y80 Major Facilitator superfamily BF25_2259 ENOG4105FQP Beta-lactamase BF25_226 ENOG4108QCI YvbH-like oligomerisation region BF25_2262 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_2262 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_2271 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF25_2273 ENOG4105T9C HD domain BF25_2276 ENOG4105DZ1 carboxypeptidase BF25_2279 ENOG4105DBI uridine monophosphokinase BF25_2280 ENOG4105WCN acetyltransferase BF25_2282 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF25_2283 ENOG4107QX3 carboxylase BF25_2284 ENOG4105E39 Enoyl-CoA hydratase BF25_2285 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF25_2286 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF25_2287 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF25_2288 ENOG4105C1G acyl-Coa dehydrogenase BF25_2291 ENOG4107Z3H Transcriptional regulator, TetR family BF25_2293 ENOG4105CJ1 ABC, transporter BF25_2296 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF25_2297 ENOG4105CEP NADH dehydrogenase BF25_2298 ENOG4106ANW SMI1_KNR4 BF25_23 ENOG4105EP9 oxidoreductase BF25_2300 ENOG4105BZU Histidine kinase BF25_2302 ENOG4105C5H ABC transporter BF25_2303 ENOG41067SE Tetr family transcriptional regulator BF25_2308 ENOG4108VXD carboxy-peptidase BF25_2311 ENOG4105VZ8 Transcriptional regulator BF25_2314 ENOG4105CGH 5'-nucleotidase BF25_2315 ENOG4105CGH 5'-nucleotidase BF25_2319 ENOG4105DH8 myo-inositol catabolism BF25_232 ENOG4108IUQ atp-dependent protease BF25_2320 ENOG4105D2N Aldolase BF25_2326 ENOG4105CK5 oxidoreductase BF25_2327 ENOG4105IE8 Alpha-ketoglutarate permease BF25_2328 ENOG4105ETE Transcriptional regulator (LacI family BF25_2329 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF25_2331 ENOG4107RF6 penicillin-binding protein BF25_2332 ENOG4107RF6 penicillin-binding protein BF25_2333 ENOG4107RF6 penicillin-binding protein BF25_2339 ENOG4105CIN aminoacyl-histidine dipeptidase BF25_2347 ENOG41090HR transcriptional regulator BF25_2348 ENOG4107RA9 decarboxylase BF25_2349 ENOG4108I0C methyltransferase BF25_2351 ENOG41088CC tellurite resistance protein tehB BF25_2355 ENOG4108RZE Tetr family transcriptional regulator BF25_2357 ENOG4105C1J atp-dependent rna helicase BF25_236 ENOG4105K56 Transcriptional regulator BF25_2360 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF25_2363 ENOG4107STF Involved in phosphonate degradation (By similarity) BF25_2365 ENOG4105RD7 BadF BadG BcrA BcrD BF25_2371 ENOG4105F32 YngK protein BF25_2376 ENOG4108KPJ rna polymerase sigma factor BF25_2381 ENOG4108JCI Transcriptional regulator BF25_2385 ENOG4105BZ1 (ABC) transporter BF25_2386 ENOG4105BZ1 (ABC) transporter BF25_2389 ENOG4108RPX mosc domain containing protein BF25_2390 ENOG4105DND Transcriptional regulator BF25_2393 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF25_2394 ENOG4107V2S Transcriptional regulator BF25_24 ENOG4107SNB ankyrin repeat protein YahD BF25_2402 ENOG410667J hydrolase BF25_2406 ENOG4105VEQ Cold shock protein BF25_2408 ENOG41068WN BF25_241 ENOG4105D52 delta-aminolevulinic acid dehydratase BF25_2410 ENOG4105C1Q protoporphyrinogen oxidase BF25_2416 ENOG4105WCN acetyltransferase BF25_2421 ENOG4105EYF MMPL domain protein BF25_2423 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF25_2426 ENOG41081I9 integral membrane protein BF25_243 ENOG41068KH stage VI sporulation protein D BF25_2432 ENOG4108D32 Methyltransferase BF25_2438 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF25_2442 ENOG4105C22 threonyL-tRNA synthetase BF25_2443 ENOG4105FE9 pseudouridine synthase BF25_2447 ENOG4105BZG amino acid carrier protein BF25_245 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF25_2451 ENOG4105K70 DNA-binding protein BF25_2454 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_2455 ENOG4105WQT MbtH domain protein BF25_2456 ENOG4105CEY Amp-dependent synthetase and ligase BF25_2457 ENOG4105WQI isochorismatase BF25_2458 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF25_2459 ENOG4105E4F Isochorismate synthase BF25_246 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF25_2460 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF25_2461 ENOG4105FCD Major Facilitator BF25_2465 ENOG4105EYH Exonuclease BF25_2466 ENOG4107RFY SbcCD D subunit BF25_2469 ENOG4105E39 Enoyl-CoA hydratase BF25_2470 ENOG4105N14 lysine exporter protein LysE YggA BF25_2472 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF25_2473 ENOG4105C1G acyl-Coa dehydrogenase BF25_2474 ENOG4105CR4 methylisocitrate lyase BF25_2475 ENOG4105DXD 2-methylcitrate dehydratase BF25_2477 ENOG4105W8X HesB YadR YfhF-family protein BF25_2478 ENOG4105CZM Major Facilitator BF25_2479 ENOG4105BZ4 penicillin-binding protein BF25_2487 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_250 ENOG4105DFF Rod shape-determining protein mreb BF25_2506 ENOG4108IBT Inherit from COG: transposase BF25_2508 ENOG4105SZ6 Thioredoxin BF25_2509 ENOG410841Q phosphoesterase PA-phosphatase related protein BF25_251 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF25_2511 ENOG4108N23 SpoOM-related protein BF25_2519 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF25_2520 ENOG4108JUB Transcriptional regulator BF25_2521 ENOG4108TSC N-acetyltransferase BF25_2522 ENOG4107S4Y M20 DapE family protein YgeY BF25_2525 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_2530 ENOG4105C37 (CBS) domain BF25_2537 ENOG4105E90 ABC transporter BF25_2538 ENOG4108IJ8 ABC transporter BF25_254 ENOG4107QMS site-determining protein BF25_2544 ENOG4105CMG Carbohydrate kinase BF25_2545 ENOG4105CMG Carbohydrate kinase BF25_2553 ENOG4106KNT transcriptional regulator BF25_2555 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_2556 ENOG4105BZU Histidine kinase BF25_2557 ENOG4105D8X mechanosensitive ion channel BF25_2564 ENOG4105F0I Aminotransferase BF25_2565 ENOG4108MES Periplasmic binding protein BF25_2569 ENOG4105CAQ asparagine synthetase BF25_257 ENOG4105C03 ribonuclease BF25_2570 ENOG4107Y70 Heat shock protein BF25_2571 ENOG4108KF3 Electron transport protein SCO1 SenC BF25_2572 ENOG4105E8R UPF0173 metal-dependent hydrolase BF25_2573 ENOG4108RCR degv family BF25_2575 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF25_2577 ENOG4108UT2 hemolysin iii BF25_2578 ENOG4105E9Q Acyl-transferase BF25_2579 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF25_2580 ENOG4107RVG penicillin-binding protein BF25_2583 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF25_2587 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF25_259 ENOG4105X36 (ribosomal) protein BF25_2592 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF25_2594 ENOG4105KD7 acetyltransferase BF25_2597 ENOG4105C0A alcohol dehydrogenase BF25_2598 ENOG4105CY2 Citrate transporter BF25_2599 ENOG4107XGZ Hydrolase BF25_26 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_2603 ENOG4105C8J )-transporter BF25_2606 ENOG41062D9 Histidine kinase BF25_2607 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_2608 ENOG4107QPK )-transporter BF25_2609 ENOG4105BZW Glycerate kinase BF25_262 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF25_2628 ENOG4105EC2 ftsk spoIIIe BF25_2632 ENOG4105C5S asparaginyl-tRNA synthetase BF25_2633 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF25_2636 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF25_2642 ENOG4105C75 arginyL-tRNA synthetase BF25_2643 ENOG4107YX5 Pfam:DUF548 BF25_2647 ENOG41061H0 Monooxygenase BF25_265 ENOG4105EWM Histidine kinase BF25_2650 ENOG4108UUM single-stranded DNA-binding protein BF25_2653 ENOG4105C5H ABC transporter BF25_2657 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF25_2660 ENOG4105MCT stage V sporulation protein S BF25_2667 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF25_2668 ENOG4108IFG nitrite reductase, (NAD(P)H) BF25_2669 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF25_2670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF25_2671 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF25_2672 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF25_2677 ENOG4108ZAF Molybdopterin BF25_2678 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_2679 ENOG4105D06 uba thif-type nad fad binding protein BF25_2680 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF25_2681 ENOG4107V6Q Cyclic nucleotide-binding domain BF25_2686 ENOG4105R3A Nitrate reductase BF25_2687 ENOG4108IUE nitrate reductase beta subunit BF25_269 ENOG4105CQC Prephenate dehydratase BF25_2691 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF25_2694 ENOG4108V06 Glutathione peroxidase BF25_2699 ENOG4105EMN RNA polymerase sigma factor BF25_270 ENOG4108RPX mosc domain containing protein BF25_2700 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF25_2702 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_2703 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF25_2707 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF25_2712 ENOG4105KBJ sporulation protein ytfj BF25_2721 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF25_2727 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF25_2728 ENOG4108JYZ YitT family BF25_2729 ENOG41087PP glycosyltransferase MGT family BF25_273 ENOG4108IYU L-aspartate oxidase BF25_2732 ENOG4107RBS Methyltransferase BF25_2733 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF25_2735 ENOG4108X4Q Hydrolase BF25_274 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF25_2740 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF25_2742 ENOG4108VXD carboxy-peptidase BF25_2744 ENOG4108ZRV stage ii sporulation protein p BF25_2748 ENOG4108Z7R Chaperone CsaA BF25_2752 ENOG4105C37 (CBS) domain BF25_2753 ENOG4105SXS Protein of unknown function (DUF456) BF25_2757 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_2759 ENOG4108S4H thioesterase Superfamily protein BF25_2761 ENOG4108PJD permease BF25_2764 ENOG4107T5V SNARE associated Golgi BF25_2768 ENOG4105CVJ phosphoglycerate mutase BF25_2773 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF25_2775 ENOG4105K4T epimerase BF25_2777 ENOG4105DSE periplasmic solute binding protein BF25_2789 ENOG4105CKI cobalamin synthesis protein BF25_279 ENOG41082BM Transcriptional regulator, arsr family BF25_2790 ENOG4107QM2 Aldo Keto reductase BF25_2794 ENOG4105DEN Luciferase family BF25_2797 ENOG4108WPJ Ferritin-like domain BF25_2798 ENOG4108K88 Membrane BF25_28 ENOG4105DGU Histone deacetylase BF25_280 ENOG4108IPJ Membrane BF25_2801 ENOG4105C8Q Methyl-accepting chemotaxis BF25_2806 ENOG4107XZQ multidrug resistance protein BF25_2807 ENOG4107SET aldo keto reductase BF25_2808 ENOG4105YVS arsR family transcriptional regulator BF25_281 ENOG4108IPJ Membrane BF25_2810 ENOG4105KRN Transcriptional regulator, abrb family BF25_2821 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF25_2823 ENOG4107RCC Major Facilitator Superfamily BF25_2825 ENOG4105YWU small acid-soluble spore protein BF25_2826 ENOG4108WBH protein TIM barrel BF25_2829 ENOG4105CEY Amp-dependent synthetase and ligase BF25_283 ENOG4108HUF Transporter BF25_2830 ENOG4105DUU IucA IucC family protein BF25_2832 ENOG4105VRR gCN5-related N-acetyltransferase BF25_2833 ENOG4105KT7 mgtC SapB transporter BF25_2835 ENOG4107VMI polysaccharide deacetylase BF25_2836 ENOG4105BZU Histidine kinase BF25_2837 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_2839 ENOG4108KGH TRANSCRIPTIONal BF25_2844 ENOG4105D6E homoserine dehydrogenase BF25_2848 ENOG4108ZJ4 polysaccharide deacetylase BF25_2849 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF25_2852 ENOG4105BZU Histidine kinase BF25_2853 ENOG4105EFI regulatoR BF25_2854 ENOG4105BZ1 (ABC) transporter BF25_2855 ENOG4105BZ1 (ABC) transporter BF25_286 ENOG41061AI Protein of unknown function (DUF2905) BF25_2863 ENOG4108JJ8 (ABC) transporter BF25_2864 ENOG4108JJ9 ABC, transporter BF25_2865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF25_2866 ENOG4105C4M (Ubiquinol oxidase) subunit I BF25_2868 ENOG4105YGB Transcriptional regulator BF25_2870 ENOG4105MDS 4-oxalocrotonate tautomerase BF25_2872 ENOG4105SKE transcriptional Regulator LysR family BF25_2874 ENOG4105C32 Amino acid ABC transporter (Permease) BF25_2875 ENOG4108IV0 ABC, transporter BF25_2876 ENOG4105C0Z ABC transporter BF25_2878 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_2879 ENOG4108Z7G MaoC domain protein dehydratase BF25_2883 ENOG4105CKI cobalamin synthesis protein BF25_2885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF25_2886 ENOG4106F5Q Membrane BF25_2887 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF25_2889 ENOG4108TVJ Nitroreductase BF25_289 ENOG4105VIE preprotein translocase, subunit YajC BF25_2890 ENOG4107ZXU DSBA oxidoreductase BF25_2891 ENOG4108Z40 Transcriptional regulator BF25_2892 ENOG4105GZI Transcriptional regulator BF25_2893 ENOG4107RT3 EamA-like transporter family BF25_2895 ENOG4105KTB nuclear export factor GLE1 BF25_2896 ENOG4108T5E Copper resistance protein BF25_29 ENOG4105W87 Cbs domain BF25_2906 ENOG4107STQ Multicopper oxidase BF25_2907 ENOG4107RAQ aminopeptidase BF25_291 ENOG4108QG2 Membrane BF25_2913 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF25_2914 ENOG4105D9N nucleoside BF25_2916 ENOG4107RHR regulatoR BF25_292 ENOG4105CKP Polysaccharide Biosynthesis Protein BF25_2921 ENOG4105C0X amino acid BF25_2922 ENOG4105C0X amino acid BF25_2924 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF25_2926 ENOG4105C72 UPF0176 protein BF25_2927 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF25_2932 ENOG41068WN BF25_2938 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_2939 ENOG4105F6J Alpha beta hydrolase fold BF25_294 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF25_2943 ENOG4105CYC Transferase BF25_2944 ENOG4105DY9 regulatoR BF25_2946 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF25_2947 ENOG4105C6X Major Facilitator BF25_295 ENOG41076HS cation diffusion facilitator family transporter BF25_2952 ENOG4105C7B Threonine dehydratase BF25_2954 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF25_2955 ENOG4108ZP8 Acetolactate synthase small subunit BF25_2956 ENOG4105C7K acetolactate synthase BF25_2957 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF25_2958 ENOG4105CHR reductase BF25_2959 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF25_296 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF25_2963 ENOG4106KE4 Dehydrogenase BF25_2966 ENOG4105H67 Protein of unknown function (DUF421) BF25_2967 ENOG4105X5K response regulator receiver protein BF25_2969 ENOG4105C8J )-transporter BF25_2973 ENOG4105C6T cysteine synthase BF25_2974 ENOG4105EU0 Major facilitator Superfamily BF25_2977 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF25_298 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF25_2980 ENOG4105DXI Major Facilitator superfamily BF25_2981 ENOG4105DXI Major Facilitator superfamily BF25_2982 ENOG4105CSR polyphosphate kinase 2 BF25_2990 ENOG4105FVX BF25_30 ENOG4105F1V Acetoin utilization protein BF25_3003 ENOG4105C6K Malic enzyme BF25_3004 ENOG4108IJ0 Aspartate ammonia-lyase BF25_3006 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF25_301 ENOG4105CUT histidyl-tRNA synthetase BF25_3010 ENOG4105CJ1 ABC, transporter BF25_3017 ENOG4106BRA Membrane BF25_3024 ENOG4107QIV Cytochrome c biogenesis protein BF25_3028 ENOG4105EC3 peptidase S51, dipeptidase E BF25_3029 ENOG4107QJQ Mate efflux family protein BF25_303 ENOG4105CUZ uba thif-type nad fad binding protein BF25_3030 ENOG4107QJQ Mate efflux family protein BF25_3034 ENOG4105C9Q fumarate hydratase class II BF25_3035 ENOG4105DFD Na H antiporter BF25_3038 ENOG4108PJD permease BF25_3039 ENOG4105CKI cobalamin synthesis protein BF25_304 ENOG4108VCI transcription factor, rsfa family BF25_3040 ENOG4108UZ3 Transporter BF25_3041 ENOG4105DRR Transcriptional regulator, GntR family BF25_3043 ENOG4105PGM cation diffusion facilitator family transporter BF25_3047 ENOG4105CAQ asparagine synthetase BF25_305 ENOG4105D1H recombination factor protein RarA BF25_3054 ENOG4105CVJ phosphoglycerate mutase BF25_3061 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF25_3062 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF25_3063 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF25_3064 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_3065 ENOG4105DUM transcriptional regulator, lysR family BF25_307 ENOG4105C3J Cysteine desulfurase BF25_3070 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF25_3074 ENOG4108RZE Tetr family transcriptional regulator BF25_3079 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_308 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF25_3080 ENOG4105KTQ flagellar basal-body rod protein BF25_3083 ENOG4105D7B Flagellar biosynthesis protein flha BF25_3084 ENOG4105D00 flagellar biosynthetic protein flhB BF25_3086 ENOG4105VS8 Flagellar biosynthetic protein fliq BF25_3087 ENOG4105CN7 Flagellar biosynthetic protein FliP BF25_3089 ENOG4105DD5 Flagellar motor switch protein BF25_3091 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF25_3092 ENOG4105E4C Lytic transglycosylase catalytic BF25_3093 ENOG4105I03 Flagellin BF25_3098 ENOG4107TVC Glycosyl transferase, family 2 BF25_310 ENOG4105C7H Helicase, RecD TraA family BF25_3104 ENOG4105K64 Glycosyl transferase, family 2 BF25_3106 ENOG4107R88 Chemotaxis protein (CheV) BF25_3107 ENOG4107R88 Chemotaxis protein (CheV) BF25_311 ENOG41060CR BF25_3111 ENOG4105BZE flagellar hook protein, FlgE BF25_3118 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF25_3120 ENOG4107U2N Flagellar M-ring protein BF25_3121 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF25_3122 ENOG4108ZC9 flagellar basal-body rod protein flgc BF25_3123 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF25_3128 ENOG4105DTJ flagellar hook-associated protein BF25_3129 ENOG4105E1Q flagellar hook-associated protein BF25_3133 ENOG4105BZU Histidine kinase BF25_3136 ENOG4105DD5 Flagellar motor switch protein BF25_3137 ENOG4105CBS Chea signal transduction histidine kinase BF25_3138 ENOG4105CBS Chea signal transduction histidine kinase BF25_3139 ENOG4107YTP response regulator receiver protein BF25_314 ENOG4105C02 permease BF25_3140 ENOG4105ER2 Ompa motb domain protein BF25_3141 ENOG4107R0U MotA TolQ exbB proton channel BF25_3143 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF25_3154 ENOG41080C8 DUF218 domain BF25_3155 ENOG4105H67 Protein of unknown function (DUF421) BF25_3157 ENOG4108Z5V transcriptional regulator, merr family BF25_3158 ENOG4105CN5 Metallo-Beta-Lactamase BF25_3159 ENOG4107RWR Sodium hydrogen exchanger BF25_316 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF25_3161 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_3174 ENOG41081VK Ribonuclease BF25_3178 ENOG4108SZE gCN5-related N-acetyltransferase BF25_3195 ENOG4106032 Glutathionylspermidine synthase BF25_3198 ENOG4105KHC sulfurtransferase BF25_320 ENOG4105HHA aminodeoxychorismate lyase BF25_3200 ENOG4108W0I acetyltransferase BF25_3202 ENOG410890F Dynamin family BF25_3204 ENOG4105DHF Membrane BF25_3205 ENOG4105C2W permease BF25_3207 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF25_321 ENOG4108VQJ O-methyltransferase BF25_3210 ENOG4105CTD carboxy-peptidase BF25_3211 ENOG4105DVT helicase BF25_3213 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF25_322 ENOG4105XYU peptidase (U32 family) BF25_3224 ENOG4105BZ4 penicillin-binding protein BF25_3226 ENOG4105CSM endonuclease III BF25_323 ENOG4105CFP Peptidase U32 BF25_3230 ENOG4105YAC BF25_3231 ENOG4105DVT helicase BF25_3238 ENOG4105CPK Glycosyl transferase (Group 1 BF25_3239 ENOG4105FJR Lmbe family BF25_3242 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF25_3243 ENOG4108JYZ YitT family BF25_3249 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF25_3250 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF25_3251 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF25_3254 ENOG41068YB TPR repeat-containing protein BF25_3255 ENOG4105CIH Imidazole acetol-phosphate transaminase BF25_3259 ENOG4105EAH synthase BF25_326 ENOG4107XRG penicillin-binding protein BF25_3261 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF25_3264 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF25_3270 ENOG41065D1 BF25_3271 ENOG4105S2F BF25_3278 ENOG4107RB3 L-asparaginase BF25_3279 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF25_3284 ENOG4108S6Z Negative regulator of genetic competence BF25_3285 ENOG4107X2D transcriptional regulator, merr family BF25_3286 ENOG4107RGJ metallophosphoesterase BF25_3288 ENOG4105I7S Abortive infection protein BF25_3289 ENOG4105C9U ATP-dependent DNA helicase RecQ BF25_3290 ENOG4105T7X BF25_3292 ENOG4108SAX Membrane BF25_3295 ENOG4108WBT adenosyltransferase BF25_3296 ENOG4105BZU Histidine kinase BF25_3297 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_3298 ENOG4105CRE cytochrome C BF25_3299 ENOG4107TWT Cytochrome c biogenesis protein BF25_33 ENOG4105EMN RNA polymerase sigma factor BF25_3301 ENOG4105FE9 pseudouridine synthase BF25_3303 ENOG4108JIC nucleoside recognition domain protein BF25_3304 ENOG4105DZ1 carboxypeptidase BF25_3305 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_3312 ENOG4105BZU Histidine kinase BF25_3315 ENOG4105I3N Conserved Protein BF25_3316 ENOG4105BZU Histidine kinase BF25_3319 ENOG4105BZ4 penicillin-binding protein BF25_332 ENOG4105C28 cystathionine BF25_3320 ENOG4107GRR phosphate transport regulator BF25_3321 ENOG4105CJ3 phosphate transporter BF25_3325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF25_333 ENOG4108EKI Dehydrogenase BF25_3330 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF25_3334 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_3335 ENOG4105ENE Histidine kinase BF25_3339 ENOG4105DFD Na H antiporter BF25_3343 ENOG4105C8J )-transporter BF25_3344 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF25_3345 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF25_3346 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF25_3348 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF25_3349 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF25_335 ENOG4108V5C ABC transporter BF25_3353 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF25_3355 ENOG4105E0M Sulfatase BF25_3356 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF25_3359 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF25_336 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF25_3366 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF25_3371 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF25_3373 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF25_3374 ENOG4108ZP8 Acetolactate synthase small subunit BF25_3375 ENOG4105C7K acetolactate synthase BF25_3376 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF25_3381 ENOG4105KBJ sporulation protein ytfj BF25_3382 ENOG41063Y9 BF25_3383 ENOG4105CZN Potassium uptake protein BF25_3389 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_3390 ENOG4107QMU Mate efflux family protein BF25_3397 ENOG4105NQC Flavodoxin BF25_3402 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_3404 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF25_3405 ENOG4105EA8 2-Nitropropane dioxygenase BF25_3406 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF25_3414 ENOG4105CJ1 ABC, transporter BF25_3416 ENOG4105CZV ABC transporter BF25_3417 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF25_3418 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF25_3419 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF25_3421 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF25_3422 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF25_3430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF25_3431 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF25_3433 ENOG4105BZU Histidine kinase BF25_3435 ENOG4106DF1 BF25_3437 ENOG41090MY MarR family Transcriptional regulator BF25_3438 ENOG4105BZU Histidine kinase BF25_344 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_3440 ENOG4105PXI polysaccharide deacetylase BF25_3442 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF25_3443 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF25_3448 ENOG4105E98 transcriptional regulator DeoR family BF25_345 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_3451 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF25_3452 ENOG4107RCV ABC transporter, permease BF25_3455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_3457 ENOG4105C4Y ABC transporter BF25_3461 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF25_3463 ENOG4105CHR reductase BF25_3467 ENOG4108Z7G MaoC domain protein dehydratase BF25_3468 ENOG410681C small acid-soluble spore protein BF25_3469 ENOG4105CZN Potassium uptake protein BF25_347 ENOG4105MIR Phenylalanine 4-monooxygenase BF25_3470 ENOG4107TS3 membrane protein, TerC BF25_3471 ENOG4108QTI )-transporter BF25_3473 ENOG4106A3R peptidase BF25_3477 ENOG4105JXH GntR family transcriptional regulator BF25_3478 ENOG4105BZU Histidine kinase BF25_3479 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_348 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF25_3482 ENOG4105CQB FAD linked oxidase domain protein BF25_3483 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF25_3484 ENOG4105K4I Scp-like extracellular BF25_3486 ENOG4108YBP pseudouridine synthase BF25_3488 ENOG4105EYF MMPL domain protein BF25_3490 ENOG4107RUE extracellular solute-binding protein family 1 BF25_3491 ENOG4105D38 putrescine abc transporter BF25_3492 ENOG4105F38 ABC transporter, permease BF25_3493 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_3494 ENOG4105C26 Dehydrogenase BF25_35 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF25_3500 ENOG4105VFR signal peptidase BF25_3501 ENOG4105DZ1 carboxypeptidase BF25_3503 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF25_3514 ENOG4105VZ8 Transcriptional regulator BF25_3516 ENOG4105C7S Dehydrogenase BF25_3534 ENOG4105DDQ anthranilate synthase BF25_3535 ENOG4105CRQ synthase (Component I) BF25_3536 ENOG4105CK7 Sodium proline symporter BF25_3541 ENOG4108WVJ 2'-5' rna ligase BF25_355 ENOG4108MUZ hydrolase BF25_3550 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF25_3552 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF25_3553 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF25_3557 ENOG4107TVC Glycosyl transferase, family 2 BF25_3561 ENOG4105K64 Glycosyl transferase, family 2 BF25_3563 ENOG4105CNI cell division protein FtsW BF25_3567 ENOG4105EMS pseudouridine synthase BF25_3568 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF25_357 ENOG4105G6Z alkaline phosphatase BF25_3571 ENOG4105MIX Adenylate cyclase BF25_3572 ENOG4108Z18 K06886 hemoglobin BF25_3575 ENOG4105DPN Oligoendopeptidase f BF25_3577 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_3579 ENOG4108ZCF integral membrane protein BF25_3583 ENOG4105UQX Mate efflux family protein BF25_3584 ENOG4108JQ7 (ABC) transporter BF25_3586 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_3587 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_3590 ENOG4105C31 Tryptophanyl-tRNA synthetase BF25_3593 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF25_3594 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF25_3599 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF25_360 ENOG4108TVJ Nitroreductase BF25_3601 ENOG4108KP7 hydrolase BF25_3603 ENOG41073B9 BF25_3604 ENOG4107AYK membrAne BF25_3606 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_3608 ENOG4105QNR S1 RNA binding domain protein BF25_3614 ENOG4105CH6 catalase BF25_3615 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF25_3616 ENOG4105CAQ asparagine synthetase BF25_3621 ENOG4105ERH Fumarylacetoacetate hydrolase BF25_3629 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF25_3630 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF25_3633 ENOG4105XVF Competence transcription factor BF25_3636 ENOG4105VEQ Cold shock protein BF25_3639 ENOG4107QP3 malate synthase g BF25_3640 ENOG4105ZU5 s-layer protein BF25_3644 ENOG4105C8Q Methyl-accepting chemotaxis BF25_3645 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF25_365 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_3650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_3654 ENOG41086D8 Transcriptional regulator BF25_3655 ENOG4108AEY RNA polymerase sigma factor BF25_3657 ENOG4107TVP HD domain protein BF25_3658 ENOG4107RN3 metallophosphoesterase BF25_3660 ENOG4105ENX hydrolase BF25_3665 ENOG4105CNA YD repeat protein BF25_3671 ENOG4105CEY Amp-dependent synthetase and ligase BF25_3673 ENOG4105DF9 Lipoate-protein, ligase BF25_3674 ENOG4108RQ5 Beta-lactamase domain-containing protein BF25_3675 ENOG4106AXD BF25_368 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF25_3681 ENOG4105ECB domain protein BF25_3684 ENOG4105NA0 Transcriptional regulator BF25_3689 ENOG4105C1Q protoporphyrinogen oxidase BF25_369 ENOG4105CQW ribosome biogenesis GTPase YqeH BF25_3691 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF25_3692 ENOG4105BZ4 penicillin-binding protein BF25_3693 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF25_3694 ENOG4105CKV Membrane BF25_3695 ENOG410905X membrane-flanked domain protein BF25_3704 ENOG4105CKV Membrane BF25_3706 ENOG410905X membrane-flanked domain protein BF25_371 ENOG410812S Rna-binding protein BF25_3713 ENOG4105K59 histidine triad (HIT) protein BF25_3718 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF25_3719 ENOG4105EEM helicase BF25_3721 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_3722 ENOG4105C57 major facilitator superfamily BF25_3727 ENOG4105EMN RNA polymerase sigma factor BF25_373 ENOG4108WF2 Metal Dependent Phosphohydrolase BF25_3730 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF25_3733 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF25_3737 ENOG4108MUZ hydrolase BF25_3742 ENOG4105EQ0 Major Facilitator superfamily BF25_3743 ENOG4108IND Tetr family transcriptional regulator BF25_3746 ENOG4105D7V transposase BF25_3747 ENOG4106D4I domain protein BF25_3748 ENOG4107VRP DNA repair exonuclease BF25_375 ENOG4105DXX methyltransferase BF25_3754 ENOG4105K8R UPF0145 protein BF25_3759 ENOG4105BZU Histidine kinase BF25_3760 ENOG4105BZU Histidine kinase BF25_3761 ENOG4108MJI response regulator BF25_3763 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_3765 ENOG4105WN5 stage II sporulation protein BF25_377 ENOG4105KQC Competence protein BF25_3778 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF25_378 ENOG4108UK2 deaminase BF25_3783 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF25_3784 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF25_3785 ENOG4105CMT Dihydroxyacetone kinase BF25_3787 ENOG4105CMT Dihydroxyacetone kinase BF25_379 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF25_3791 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF25_3795 ENOG4108IG5 Transcriptional regulator BF25_3796 ENOG4107P5I polyketide synthase BF25_3806 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_381 ENOG4105TQK DNA polymerase iii, delta' subunit BF25_3814 ENOG4105CDU Replicative dna helicase BF25_3823 ENOG4108MRH transcriptional regulatory protein BF25_3825 ENOG4105CSH Transporter BF25_3831 ENOG4108JQ7 (ABC) transporter BF25_3834 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_3842 ENOG4105CTU Proline racemase BF25_3846 ENOG4105DER m42 family BF25_3849 ENOG4105CGU Enoyl-CoA hydratase BF25_3852 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_3853 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF25_3855 ENOG4106AKK s-layer domain-containing protein BF25_386 ENOG4105KVH Transcriptional regulator BF25_3863 ENOG4105CHH sulfate transporter BF25_3866 ENOG4105D4P Coproporphyrinogen iii oxidase BF25_3868 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF25_387 ENOG4105CSA Coproporphyrinogen iii oxidase BF25_3873 ENOG4107FQX Alpha-acetolactate decarboxylase BF25_3880 ENOG410839P BF25_3883 ENOG4105CDA abc transporter atp-binding protein BF25_3884 ENOG4105DRP amino acid AbC transporter BF25_3886 ENOG4105BZ1 (ABC) transporter BF25_3887 ENOG4105BZ1 (ABC) transporter BF25_3888 ENOG4105BZ1 (ABC) transporter BF25_3889 ENOG4105C26 Dehydrogenase BF25_389 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF25_3891 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF25_3892 ENOG4105D5Q Arginine ornithine antiporter BF25_3894 ENOG4105CH6 catalase BF25_3895 ENOG4107RKG DJ-1/PfpI family BF25_3897 ENOG4105E5W Transporter BF25_3898 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF25_3899 ENOG4105NF4 modulator of drug activity BF25_39 ENOG4105C28 cystathionine BF25_3904 ENOG4105KPY Small multidrug resistance protein BF25_3905 ENOG4105KPY Small multidrug resistance protein BF25_3907 ENOG4108YXU transcriptional regulator AsnC family BF25_3908 ENOG4108PCN EamA-like transporter family BF25_3915 ENOG4106KNT transcriptional regulator BF25_3917 ENOG4107RWR Sodium hydrogen exchanger BF25_3918 ENOG4105CUB amino acid BF25_3924 ENOG4107T5V SNARE associated Golgi BF25_393 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF25_3931 ENOG4105WEF catalase BF25_3937 ENOG4105C19 ABC transporter BF25_3938 ENOG4107RBB ABC transporter, permease BF25_3939 ENOG41069ER domain protein BF25_394 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF25_3943 ENOG4105VZJ PTS System BF25_3944 ENOG4105VCP PTS System BF25_3945 ENOG4105EMD TRANSCRIPTIONal BF25_3950 ENOG4108KGH TRANSCRIPTIONal BF25_3952 ENOG41087NI Sulfite exporter TauE/SafE BF25_3953 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF25_3955 ENOG41085GJ domain protein BF25_3957 ENOG4105VFE sira family BF25_3958 ENOG4107TPS domain protein BF25_3959 ENOG4105VFE sira family BF25_396 ENOG4105KTH gatB Yqey BF25_3960 ENOG4105XTG Pfam:DUF156 BF25_3961 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF25_3966 ENOG4105ED1 spovr family BF25_3967 ENOG4107Y03 Nitroreductase BF25_397 ENOG41068P3 sporulation protein YqfC BF25_3972 ENOG4108B31 Spore germination protein BF25_3979 ENOG4105C5Y PTS System BF25_3986 ENOG4105C7N Xanthine uracil vitamin C permease BF25_3989 ENOG4108INS Transcriptional regulator BF25_399 ENOG4105C9A Phoh family BF25_3998 ENOG4105DWF phosphomethylpyrimidine kinase BF25_3999 ENOG4105D06 uba thif-type nad fad binding protein BF25_4 ENOG4108VDD TRNA binding domain protein BF25_400 ENOG4105CTJ Metal Dependent Phosphohydrolase BF25_4002 ENOG41080HI glycine oxidase BF25_4003 ENOG4108VEU Thiamine monophosphate synthase BF25_4005 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF25_4007 ENOG4105ETU transcriptional activator (TenA BF25_4011 ENOG41080XQ Signal transduction protein with cbs domains BF25_402 ENOG4107YR5 Diacylglycerol kinase BF25_403 ENOG4105KG3 cytidine deaminase BF25_4038 ENOG4105E2Z phosphate ABC transporter (Permease BF25_4039 ENOG4105C8U phosphate abc transporter BF25_404 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF25_4040 ENOG4105CVA phosphate BF25_4041 ENOG4105CE1 Ferrous iron transport protein b BF25_4042 ENOG4105CE1 Ferrous iron transport protein b BF25_4043 ENOG4105CE1 Ferrous iron transport protein b BF25_4044 ENOG4108NHD germination protein BF25_4047 ENOG4105E1V na solute symporter BF25_4048 ENOG4106CAD Protein of unknown function (DUF3311) BF25_4051 ENOG4105E2S oxidase) subunit II BF25_4052 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF25_4060 ENOG4105C7N Xanthine uracil vitamin C permease BF25_4061 ENOG4105C85 amino acid BF25_4065 ENOG4105DUX Transporter BF25_4067 ENOG4107D63 BF25_4068 ENOG4105VZ8 Transcriptional regulator BF25_4069 ENOG41069ER domain protein BF25_4070 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF25_4071 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_4083 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF25_4084 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF25_4085 ENOG4105CNN ABC, transporter BF25_4086 ENOG4105C2J ABC transporter BF25_4088 ENOG4108RVA ribokinase BF25_4089 ENOG4105ETE Transcriptional regulator (LacI family BF25_409 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF25_4090 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_4091 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF25_4092 ENOG41067TZ transcriptional regulator, MarR family BF25_4093 ENOG4105CXY transporter BF25_4095 ENOG4108JQ7 (ABC) transporter BF25_4096 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_4098 ENOG4105DEF Extracellular solute-binding protein, family 5 BF25_41 ENOG4105U5Y Transcriptional regulator BF25_410 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_4100 ENOG41068KF Universal stress protein BF25_4101 ENOG4105CHH sulfate transporter BF25_4105 ENOG4105BZU Histidine kinase BF25_4106 ENOG4105NAE bifunctional deaminase-reductase domain protein BF25_4107 ENOG4105D29 Helix-turn-helix type 11 domain protein BF25_4112 ENOG4108IQI permease BF25_4113 ENOG4105DRP amino acid AbC transporter BF25_4114 ENOG4105EAD ABC transporter BF25_4115 ENOG4105CT1 (ABC) transporter BF25_4116 ENOG4105CDA abc transporter atp-binding protein BF25_4117 ENOG4105BZG amino acid carrier protein BF25_4118 ENOG4105CRN Aminoglycoside phosphotransferase BF25_4120 ENOG4105E1K spore germination protein BF25_4123 ENOG4105CG3 alpha amylase, catalytic region BF25_4124 ENOG4105C5Y PTS System BF25_4125 ENOG4107414 GntR family transcriptional regulator BF25_4126 ENOG4105D5Q Arginine ornithine antiporter BF25_4127 ENOG4105BZU Histidine kinase BF25_413 ENOG4105EGD dinuclear metal center protein, YbgI family BF25_4130 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF25_4131 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF25_4132 ENOG4107T89 von Willebrand factor, type A BF25_4134 ENOG4105EXW epimerase dehydratase BF25_4136 ENOG4105DMQ Methyltransferase BF25_4137 ENOG4105E0A ABC, transporter BF25_4138 ENOG4108IHU transport system permease protein BF25_4139 ENOG4105DQ5 transport system permease protein BF25_4140 ENOG4108MES Periplasmic binding protein BF25_4141 ENOG4105DUX Transporter BF25_4144 ENOG4105DAA L-lactate BF25_4145 ENOG4108IJ0 Aspartate ammonia-lyase BF25_4146 ENOG4105C37 (CBS) domain BF25_4147 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF25_4148 ENOG4105D9N nucleoside BF25_4149 ENOG4108KGH TRANSCRIPTIONal BF25_4150 ENOG41073R8 VanW family BF25_4157 ENOG4105DAP Nicotinate phosphoribosyltransferase BF25_4158 ENOG4105C59 p-type ATPase BF25_4160 ENOG4105CUB amino acid BF25_4165 ENOG4108JB9 formate dehydrogenase BF25_4166 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF25_4167 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF25_4169 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_4170 ENOG4105BZU Histidine kinase BF25_4172 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF25_4173 ENOG4108UZ3 Transporter BF25_4175 ENOG4105C6K Malic enzyme BF25_4177 ENOG4108MRH transcriptional regulatory protein BF25_418 ENOG41069ZM Protein of unknown function (DUF2624) BF25_4182 ENOG4105US7 Histidine kinase BF25_4183 ENOG4108STX response regulator BF25_4184 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF25_4185 ENOG4105BZ7 extracellular solute-binding protein family 1 BF25_4186 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF25_4187 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF25_4188 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF25_4189 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF25_419 ENOG4108JYZ YitT family BF25_4193 ENOG4105D4T Citrate transporter BF25_4196 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF25_4198 ENOG4105DZ6 Band 7 protein BF25_42 ENOG4105U5Y Transcriptional regulator BF25_420 ENOG4105FDK ABC transporter BF25_4201 ENOG4105C94 Transporter BF25_4205 ENOG4105CYN Serine protein kinase BF25_4207 ENOG4105BZU Histidine kinase BF25_4208 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF25_4210 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF25_4212 ENOG4107ZQN disulfide bond BF25_4213 ENOG4108JQC penicillin-binding protein 1A BF25_422 ENOG4105N80 Ferric uptake regulator, Fur family BF25_4238 ENOG4105G5W regulator Fur family BF25_4239 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF25_4243 ENOG4108IUW ABC transporter BF25_4245 ENOG4105CBC glutamate synthase BF25_4246 ENOG4107NBY Membrane BF25_4247 ENOG4105BZ1 (ABC) transporter BF25_4250 ENOG4106BXE BF25_4251 ENOG4105CEN a g-specific adenine glycosylase BF25_4252 ENOG41067AE Membrane-bound metal-dependent hydrolase BF25_4258 ENOG4105ECP epimerase BF25_4259 ENOG4105CI2 imidazolone-5-propionate hydrolase BF25_4263 ENOG4105F1A Pyruvate formate-lyase BF25_4266 ENOG4105C3I Nad-dependent epimerase dehydratase BF25_4267 ENOG4107QQG Dehydrogenase BF25_4269 ENOG4105CKK Glycosyl transferase, family 2 BF25_427 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_4272 ENOG4108A04 Beta-lactamase BF25_4274 ENOG4105CSV Glutaminase BF25_4280 ENOG4108IQI permease BF25_4282 ENOG4108JUB Transcriptional regulator BF25_4284 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF25_429 ENOG4107RF6 penicillin-binding protein BF25_430 ENOG4105PWN phosphate abc transporter BF25_431 ENOG4105C8U phosphate abc transporter BF25_432 ENOG4105E2Z phosphate ABC transporter (Permease BF25_433 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF25_434 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF25_4342 ENOG4105VTR Integrase BF25_4343 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF25_4351 ENOG4105UPD Calcium Proton BF25_4352 ENOG410606W general stress protein BF25_4355 ENOG4107ZTW SNARE associated Golgi BF25_4358 ENOG4105C3F Signal peptidase i BF25_4360 ENOG4108IPJ Membrane BF25_4361 ENOG4105C59 p-type ATPase BF25_4362 ENOG4107U9T Pfam:Ribonuclease_BN BF25_4364 ENOG4105KJF protein tyrosine phosphatase BF25_4368 ENOG4108TTB tellurium resistance protein BF25_4369 ENOG4107TS3 membrane protein, TerC BF25_437 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF25_4370 ENOG4106FN3 tellurium resistance protein BF25_4371 ENOG4106FN3 tellurium resistance protein BF25_4372 ENOG4108N0M stress protein BF25_4375 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF25_4378 ENOG4105DEU major facilitator superfamily BF25_4382 ENOG41062JF Transcriptional regulator BF25_4387 ENOG4105C5H ABC transporter BF25_439 ENOG4105DKQ ROK family BF25_4390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF25_4393 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF25_4399 ENOG4105CI1 PTS System BF25_44 ENOG4106KR7 LysR family Transcriptional regulator BF25_4401 ENOG4105C8Q Methyl-accepting chemotaxis BF25_4402 ENOG4105C8Q Methyl-accepting chemotaxis BF25_4404 ENOG4105EAB amino acid AbC transporter BF25_4405 ENOG4105E5Q amino acid AbC transporter BF25_4408 ENOG4105D2S major facilitator superfamily BF25_4409 ENOG410756H nucleotidyltransferase BF25_441 ENOG4105C5X domain protein BF25_4413 ENOG4105BZU Histidine kinase BF25_4417 ENOG4106UIA BF25_4418 ENOG4106UIA BF25_4422 ENOG4108V5C ABC transporter BF25_4423 ENOG4105DQ5 transport system permease protein BF25_4424 ENOG4105EHG Permease protein BF25_4425 ENOG4107W7X Aldolase BF25_4427 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF25_4428 ENOG4105D3R alkyl hydroperoxide reductase BF25_4433 ENOG4105DFD Na H antiporter BF25_4434 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_4437 ENOG4108W15 Protein of unknown function (DUF1456) BF25_4440 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF25_4441 ENOG4105D9N nucleoside BF25_4446 ENOG4105KPY Small multidrug resistance protein BF25_4447 ENOG4105C26 Dehydrogenase BF25_4449 ENOG4108JPW Aminotransferase BF25_445 ENOG4105C28 cystathionine BF25_4450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF25_4451 ENOG4105CBD Diacylglycerol kinase BF25_4456 ENOG410834F Transcriptional regulator BF25_4457 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF25_446 ENOG4105C28 cystathionine BF25_4461 ENOG4105D01 (LipO)protein BF25_4462 ENOG4108UMI ABC transporter, permease BF25_4463 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_4464 ENOG4108W2Y isochorismatase BF25_4470 ENOG4105C4R Atp-dependent dna helicase BF25_4475 ENOG4105C12 Phosphoribosylglycinamide synthetase BF25_4477 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF25_448 ENOG4105C3R Methionine synthase BF25_4482 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF25_4484 ENOG4105C83 adenylosuccinate lyase BF25_4485 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF25_4486 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF25_449 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF25_4491 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF25_4495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF25_4499 ENOG4108SHN Glycosyl transferase, family 2 BF25_4505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_4514 ENOG4105BZU Histidine kinase BF25_4516 ENOG4105C7N Xanthine uracil vitamin C permease BF25_4520 ENOG4108TYN CAAX amino terminal protease family protein BF25_4523 ENOG4105C5H ABC transporter BF25_4524 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF25_4525 ENOG410801F ribosomal-protein-alanine acetyltransferase BF25_4526 ENOG41072GX Peptidase M22 Glycoprotease BF25_4527 ENOG4105K8N protein family UPF0079, ATPase BF25_4546 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF25_4548 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF25_4549 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF25_4552 ENOG4107ZXI Rhomboid family BF25_4554 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF25_4555 ENOG4105CPF Cell wall formation (By similarity) BF25_4556 ENOG4105CPF Cell wall formation (By similarity) BF25_4557 ENOG4108SC4 )-transporter BF25_4559 ENOG4105ERH Fumarylacetoacetate hydrolase BF25_4560 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF25_4564 ENOG4108JQ7 (ABC) transporter BF25_4565 ENOG410667J hydrolase BF25_4566 ENOG4105C3U ABC transporter BF25_4567 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_4569 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF25_4572 ENOG4105C5H ABC transporter BF25_4576 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF25_4577 ENOG4108RE7 deoxyribonuclease BF25_4580 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF25_4584 ENOG4105F6E Acyl-transferase BF25_4588 ENOG4105EGI Transcriptional regulator BF25_4591 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF25_4592 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF25_4593 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF25_4594 ENOG4105E0C molybdate abc transporter BF25_4596 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF25_4597 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_4599 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_4600 ENOG4108J59 Extracellular solute-binding protein, family 5 BF25_4606 ENOG4108JQ7 (ABC) transporter BF25_4607 ENOG4105C3U ABC transporter BF25_4608 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF25_4609 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF25_4612 ENOG4105C2C drug resistance transporter, Bcr CflA BF25_4615 ENOG4105IQ5 FAD linked oxidase domain protein BF25_4617 ENOG4105EE1 crotonyl-CoA reductase BF25_4618 ENOG4105D01 (LipO)protein BF25_4619 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_4620 ENOG4108UMI ABC transporter, permease BF25_4621 ENOG4108PSK reductase BF25_4629 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF25_4630 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF25_4632 ENOG4105CMG Carbohydrate kinase BF25_4633 ENOG4105CMG Carbohydrate kinase BF25_4635 ENOG4108VQT Alpha beta hydrolase fold protein BF25_4636 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF25_4638 ENOG4107U5W ybbr family BF25_4639 ENOG4105C8B TIGR00159 family BF25_4657 ENOG4108NMV polysaccharide deacetylase BF25_4660 ENOG4105D1F ATP-binding protein BF25_4665 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF25_4666 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF25_4667 ENOG4108JJB ABC transporter BF25_4673 ENOG41067V7 50S ribosomal protein L36 BF25_4675 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF25_4677 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF25_4682 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF25_4703 ENOG4105XPM ribosomal protein BF25_4704 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF25_4706 ENOG4107Y49 methyltransferase BF25_4711 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF25_4713 ENOG4105QIV RNA polymerase BF25_4714 ENOG4105M0M Tetracycline resistance protein BF25_4715 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF25_4718 ENOG4105D7W serine acetyltransferase BF25_4722 ENOG4105CTP PilT protein domain protein BF25_4724 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF25_4727 ENOG4108Z0C Uvrb UvrC protein BF25_473 ENOG4105C0D helicase BF25_4734 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF25_4736 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF25_4737 ENOG4105KRF dihydroneopterin aldolase BF25_4738 ENOG4105EEI dihydropteroate synthase BF25_4739 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF25_4740 ENOG4105DDQ anthranilate synthase BF25_4741 ENOG4105CRQ synthase (Component I) BF25_4742 ENOG4105C6T cysteine synthase BF25_4745 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF25_4746 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF25_4747 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF25_4751 ENOG41060GV RNA binding s1 domain protein BF25_4754 ENOG4105VYY sporulation protein yabp BF25_4755 ENOG41082I2 s4 domain protein BF25_4756 ENOG4108IY2 MazG family BF25_4758 ENOG4108M14 stage v sporulation protein t BF25_4759 ENOG4108JA2 transcriptioN-repair coupling factor BF25_4761 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF25_4762 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF25_4765 ENOG4105KME endoribonuclease L-psp BF25_4766 ENOG4105DFT pur operon repressor BF25_4769 ENOG4105W42 Veg protein BF25_4770 ENOG4105XFA sporulation peptidase YabG BF25_4772 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF25_4773 ENOG4105F8V Hydrolase, tatD family BF25_4775 ENOG4105KRN Transcriptional regulator, abrb family BF25_4776 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF25_4778 ENOG41060K3 Methyltransferase BF25_4780 ENOG4105MA4 psp1 domain protein BF25_4781 ENOG4105FA2 dna polymerase iii BF25_4783 ENOG4105CXN decarboxylase BF25_479 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_4791 ENOG41067KS pro-sigma K processing BF25_4795 ENOG4105C6E dna polymerase iii BF25_4796 ENOG4108Z6B deaminase BF25_4797 ENOG4105GTG Isochorismatase BF25_4799 ENOG4105ZMH deoxynucleoside kinase BF25_480 ENOG4105CJ1 ABC, transporter BF25_4806 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF25_4814 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF25_4817 ENOG410848D S4 domain protein YaaA BF25_4818 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF25_4822 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF25_4824 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF25_4828 ENOG4107QJE Chromosome Partitioning Protein BF25_4829 ENOG4105FA0 parb-like partition protein BF25_4830 ENOG4108ZDA Sporulation protein YyaC BF25_4831 ENOG4105D8X mechanosensitive ion channel BF25_4832 ENOG4105VDK protein, conserved in bacteria BF25_4833 ENOG4105C3G gtp-binding protein BF25_4835 ENOG4108UUM single-stranded DNA-binding protein BF25_4837 ENOG4108XMW Membrane BF25_4838 ENOG4105BZR domain protein BF25_4840 ENOG4105CDU Replicative dna helicase BF25_4846 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_4847 ENOG4105BZU Histidine kinase BF25_4850 ENOG4105Q2H domain protein BF25_4851 ENOG4105C0H protease BF25_4855 ENOG4105DPN Oligoendopeptidase f BF25_4858 ENOG4105C1J atp-dependent rna helicase BF25_4860 ENOG4108UT2 hemolysin iii BF25_4861 ENOG4105CMR udp-glucose 4-epimerase BF25_4863 ENOG4105IW1 AmiS UreI transporter BF25_4865 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF25_4868 ENOG4107RGD Major Facilitator superfamily BF25_4869 ENOG4108HRK Histidine kinase BF25_4870 ENOG4105DY9 regulatoR BF25_4873 ENOG4106F5Q Membrane BF25_4874 ENOG4105E0X reductase BF25_4876 ENOG41067SE Tetr family transcriptional regulator BF25_4877 ENOG4105CKK Glycosyl transferase, family 2 BF25_488 ENOG41080TC multidrug resistance protein BF25_4882 ENOG4105C5H ABC transporter BF25_4883 ENOG4105JEU Glycosyl transferase, family 2 BF25_4885 ENOG4108S4H thioesterase Superfamily protein BF25_4887 ENOG4106YBV Methyl-accepting chemotaxis BF25_4888 ENOG4105EN6 Membrane BF25_4892 ENOG41079KZ Major Facilitator Superfamily BF25_4893 ENOG4105DY9 regulatoR BF25_4894 ENOG4105D22 carbon starvation protein BF25_4895 ENOG4105VCD cytoplasmic protein BF25_4896 ENOG4105BZU Histidine kinase BF25_4897 ENOG4105DWF phosphomethylpyrimidine kinase BF25_4898 ENOG4105BZU Histidine kinase BF25_4899 ENOG4105BZU Histidine kinase BF25_49 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF25_4900 ENOG4105WH1 Two component transcriptional regulator luxr family BF25_4902 ENOG4108Y4K DNA-binding transcriptional activator BF25_4907 ENOG4105D6E homoserine dehydrogenase BF25_4910 ENOG41090WU lipolytic protein G-D-S-L family BF25_4911 ENOG4105CJ1 ABC, transporter BF25_4912 ENOG4108TU7 Inherit from COG: (ABC) transporter BF25_4914 ENOG4105VCH membrane BF25_4915 ENOG410667J hydrolase BF25_492 ENOG4105WZW rhodanese family BF25_4922 ENOG4108VKI Cell wall hydrolase BF25_4925 ENOG4108IJ2 phosphate acetyltransferase BF25_4928 ENOG4108VCI transcription factor, rsfa family BF25_493 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF25_4930 ENOG4105DQ5 transport system permease protein BF25_4931 ENOG4105DQ5 transport system permease protein BF25_4932 ENOG4105EHG Permease protein BF25_4933 ENOG4105E0A ABC, transporter BF25_4934 ENOG4108MES Periplasmic binding protein BF25_4935 ENOG4105DCI Phosphohydrolase BF25_4936 ENOG41069HH 4-oxalocrotonate tautomerase BF25_4937 ENOG4108Z4T Peptidase M50 BF25_4938 ENOG4108XFG YwhD family BF25_4939 ENOG4105BZ4 penicillin-binding protein BF25_4940 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF25_4941 ENOG4107SWG transcriptional regulator MERR family BF25_4942 ENOG4105DXB Major Facilitator superfamily BF25_4944 ENOG4105CYW agmatinase BF25_4948 ENOG410684U Domain of unknown function (DUF1934) BF25_4950 ENOG4105EMN RNA polymerase sigma factor BF25_4954 ENOG4105IIU Aminopeptidase BF25_4958 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF25_4959 ENOG4108M15 ABC transporter BF25_4960 ENOG4105KCT ABC transporter BF25_4961 ENOG4105BZU Histidine kinase BF25_4966 ENOG4105BZU Histidine kinase BF25_4969 ENOG4105DF6 Fe-S oxidoreductase BF25_4971 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF25_4972 ENOG4105C1G acyl-Coa dehydrogenase BF25_4973 ENOG4105C1G acyl-Coa dehydrogenase BF25_498 ENOG4107YBY Hydrolase BF25_4980 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF25_4981 ENOG4105CBT Fructose-1,6-bisphosphatase BF25_4982 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF25_4985 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF25_4986 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF25_4987 ENOG4108ZXQ stage ii sporulation protein r BF25_4989 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF25_499 ENOG4105CBJ Metal-dependent enzyme BF25_4992 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF25_4993 ENOG4108VGI doxx family BF25_4996 ENOG4108YZG isomerase BF25_5001 ENOG41062M3 atp synthase BF25_5002 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF25_5012 ENOG4105BZU Histidine kinase BF25_5013 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF25_5015 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF25_5016 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF25_502 ENOG4105DC7 peptidase M24 BF25_5021 ENOG4105D65 subunit l BF25_5022 ENOG4105C8S subunit m BF25_5023 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF25_5024 ENOG4106778 Protein of unknown function (DUF1146) BF25_5028 ENOG4108IUW ABC transporter BF25_5029 ENOG4105DY9 regulatoR BF25_5032 ENOG4105FRN stage II sporulation protein BF25_5034 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF25_5044 ENOG4105EY8 ABC transporter BF25_5045 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF25_5048 ENOG4105CMR udp-glucose 4-epimerase BF25_5049 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_5050 ENOG4105BZU Histidine kinase BF25_5053 ENOG4105CXY transporter BF25_5057 ENOG4105C19 ABC transporter BF25_5058 ENOG4107RBB ABC transporter, permease BF25_5060 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_5066 ENOG4105C0D helicase BF25_5067 ENOG4105KBK Zinc finger, swim domain protein BF25_507 ENOG4105CD2 stage iii sporulation protein aa BF25_5072 ENOG41069ER domain protein BF25_5073 ENOG4105C94 Transporter BF25_508 ENOG4105KR5 Stage iii sporulation protein BF25_5082 ENOG4105E0M Sulfatase BF25_5085 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF25_5087 ENOG4105DAA L-lactate BF25_509 ENOG4108CQH stage III sporulation protein AC BF25_5096 ENOG4107RSM transcriptional regulator BF25_5097 ENOG4105ECB domain protein BF25_5098 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF25_51 ENOG4105EFZ amidohydrolase BF25_510 ENOG4105KQ4 Stage iii sporulation protein ad BF25_5101 ENOG4105VZJ PTS System BF25_5103 ENOG4105VCP PTS System BF25_5104 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF25_5105 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF25_5107 ENOG4105CK1 PTS System BF25_5108 ENOG4105VCP PTS System BF25_5109 ENOG4105F8D glycoside hydrolase family 4 BF25_5110 ENOG410901P UPF0249 protein BF25_5113 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF25_5115 ENOG4105ESV Glycosyl transferase, family 4 BF25_5116 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF25_5117 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF25_5118 ENOG4108KGH TRANSCRIPTIONal BF25_5119 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF25_512 ENOG410644B Stage III sporulation protein af BF25_5121 ENOG4105KVH Transcriptional regulator BF25_5124 ENOG41081UC Inherit from COG: Competence protein BF25_5125 ENOG4105VEQ Cold shock protein BF25_5126 ENOG4105MS2 ribosomal subunit Interface protein BF25_5127 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF25_5128 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF25_5130 ENOG4105CAK Cell division ATP-binding protein ftsE BF25_5131 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF25_5132 ENOG4105CN1 protease BF25_5134 ENOG4105BZ1 (ABC) transporter BF25_5137 ENOG4108WS4 fmn reductase BF25_5139 ENOG4105DUM transcriptional regulator, lysR family BF25_5140 ENOG4105HMI Membrane BF25_5144 ENOG4107TXC Transcriptional regulator BF25_5147 ENOG4105D7V transposase BF25_5148 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF25_5149 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF25_5151 ENOG41086DT Membrane protein of unknown function BF25_5155 ENOG4108S4C acetyltransferase BF25_5157 ENOG4105C3M thioredoxin reductase BF25_5159 ENOG4108Z4K mutator MutT protein BF25_5161 ENOG4105CHW UPF0052 protein BF25_5163 ENOG4105KRI phosphocarrier protein (HPr BF25_5164 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF25_5165 ENOG4105H67 Protein of unknown function (DUF421) BF25_5168 ENOG4105CZ3 stage V sporulation protein ad BF25_5169 ENOG41090VF Stage v sporulation protein ac BF25_517 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF25_5173 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_5178 ENOG4105CP7 Triose-phosphate isomerase BF25_5179 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF25_518 ENOG4108ZSR alkaline shock protein BF25_5181 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_5186 ENOG4105EFC phage portal protein HK97 family BF25_5205 ENOG41067MG lrgb family BF25_5206 ENOG4105XZU Preprotein translocase, subunit SecG BF25_5208 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF25_5213 ENOG4105CM4 permease protein BF25_5214 ENOG4108IPW abc transporter atp-binding protein BF25_5217 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF25_5218 ENOG4108MK9 spermidine N(1)-acetyltransferase BF25_5221 ENOG4105WMR Protein CrcB homolog BF25_5222 ENOG4105WMR Protein CrcB homolog BF25_5224 ENOG4105C8Q Methyl-accepting chemotaxis BF25_5226 ENOG4105D4A Cell wall formation (By similarity) BF25_5227 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF25_523 ENOG4105CTB Polyprenyl synthetase BF25_5230 ENOG4105KVH Transcriptional regulator BF25_5231 ENOG4105F27 Major Facilitator BF25_5232 ENOG4105CV8 reductase BF25_5237 ENOG4108RYK Nad-dependent epimerase dehydratase BF25_5240 ENOG4105D9N nucleoside BF25_5241 ENOG4105D9N nucleoside BF25_5246 ENOG4108URH decarboxylase BF25_5249 ENOG4108RMU ferritin dps family protein BF25_525 ENOG4105DX0 Hemolysin A BF25_5251 ENOG4105NCW Trka-c domain protein BF25_5252 ENOG4107S91 Sodium hydrogen exchanger BF25_5256 ENOG4105D4Y metalloprotease BF25_5257 ENOG4105VG1 fes assembly suf system protein BF25_5260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF25_5262 ENOG4105BZU Histidine kinase BF25_5263 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_5264 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF25_5266 ENOG4107ZTW SNARE associated Golgi BF25_527 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF25_5273 ENOG4107AYK membrAne BF25_5275 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF25_5277 ENOG4107R7I amino acid BF25_5278 ENOG4108SUT Major Facilitator Superfamily BF25_528 ENOG4105S1Z Stage IV sporulation protein B BF25_5282 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF25_5286 ENOG4105DZ1 carboxypeptidase BF25_5289 ENOG4105CHU acetyl-coa acetyltransferase BF25_529 ENOG4107QQR Sporulation BF25_5290 ENOG4105C1G acyl-Coa dehydrogenase BF25_5291 ENOG4108W8B Beta-lactamase domain protein BF25_5297 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF25_5306 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF25_5312 ENOG4108UMI ABC transporter, permease BF25_5313 ENOG4105D01 (LipO)protein BF25_5314 ENOG4105D01 (LipO)protein BF25_5315 ENOG4105C3K feS assembly ATPase SufC BF25_5316 ENOG4105JRK feS assembly protein SufD BF25_5317 ENOG4105C9B Cysteine desulfurase BF25_5318 ENOG4108UNV SUF system FeS assembly protein, NifU family BF25_5319 ENOG4105DIW FeS assembly protein SUFB BF25_532 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF25_5322 ENOG4107R8B 5'-nucleotidase BF25_5323 ENOG4105KZD Domain of unknown function (DUF1805) BF25_5325 ENOG4105FAA peptidase M23 BF25_5330 ENOG41090T1 Membrane BF25_5331 ENOG4107TXC Transcriptional regulator BF25_5332 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF25_5333 ENOG4105MMD transcriptional regulator BF25_5336 ENOG4105CBT Fructose-1,6-bisphosphatase BF25_5339 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF25_534 ENOG4108JUB Transcriptional regulator BF25_5340 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF25_5342 ENOG4108W5N phosphatidylglycerophosphatase a BF25_5345 ENOG41083MR nifu domain-containing protein BF25_5354 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF25_5355 ENOG4105C4B ABC transporter, permease BF25_5356 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF25_536 ENOG4107RDP Dehydrogenase BF25_5360 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF25_5363 ENOG4105EWC Purine nucleoside phosphorylase BF25_5370 ENOG4105CEP NADH dehydrogenase BF25_5373 ENOG41069ER domain protein BF25_5377 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF25_5381 ENOG4105KA0 thioesterase Superfamily protein BF25_5382 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF25_5385 ENOG4107R3E Citrate transporter BF25_5387 ENOG4105Y38 Kinase-associated protein B BF25_5390 ENOG4105C87 Aminotransferase class I and II BF25_5392 ENOG4108MUZ hydrolase BF25_5393 ENOG4105C5I Dehydrogenase BF25_5394 ENOG4108ZB6 transcriptional regulator AsnC family BF25_5395 ENOG4105CHM Aminotransferase BF25_5397 ENOG4105WG9 Conserved Protein BF25_5398 ENOG4107QYV phosphohexose isomerase BF25_5399 ENOG4107PBV potassium channel BF25_54 ENOG4105KBJ sporulation protein ytfj BF25_540 ENOG4105CPP Dehydrogenase, E1 component BF25_5401 ENOG4105KT7 mgtC SapB transporter BF25_5409 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF25_541 ENOG4105C7S Dehydrogenase BF25_5428 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF25_543 ENOG4105E09 nadh pyrophosphatase BF25_5430 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF25_5432 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF25_5437 ENOG4105VEQ Cold shock protein BF25_5439 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF25_544 ENOG4105G7B Protein of unknown function (DUF2992) BF25_5440 ENOG4105E4F Isochorismate synthase BF25_5441 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF25_5442 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF25_5443 ENOG4108IPT Naphthoate synthase BF25_5445 ENOG4105DTQ mandelate racemase muconate lactonizing BF25_5451 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF25_5455 ENOG4105FDP GntR family transcriptional regulator BF25_5456 ENOG4105C6Z Gluconate BF25_546 ENOG4108HW3 (ABC) transporter BF25_5467 ENOG41086D8 Transcriptional regulator BF25_5468 ENOG4105C19 ABC transporter BF25_547 ENOG4105E5Q amino acid AbC transporter BF25_5471 ENOG4107ZTW SNARE associated Golgi BF25_5478 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF25_5479 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF25_548 ENOG4105CDA abc transporter atp-binding protein BF25_5484 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF25_5485 ENOG4105BZU Histidine kinase BF25_549 ENOG4108QEG Membrane BF25_5492 ENOG41087YS Phage shock protein A BF25_55 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF25_550 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF25_5501 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF25_5502 ENOG4105C4M (Ubiquinol oxidase) subunit I BF25_5504 ENOG4108V2W Carbonate dehydratase BF25_5511 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF25_5515 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF25_5517 ENOG4105D2X ABC transporter substrate-binding protein BF25_552 ENOG4105D9U N-acetyltransferase BF25_5521 ENOG4107T7U Sulfatase BF25_5522 ENOG4107S9D Alpha beta hydrolase BF25_5523 ENOG4105BZU Histidine kinase BF25_5524 ENOG4105BZU Histidine kinase BF25_5525 ENOG4105EGD dinuclear metal center protein, YbgI family BF25_553 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF25_5535 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF25_5537 ENOG4105BZF Glycosyl transferase (Group 1 BF25_5538 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF25_5539 ENOG4108Z0R Transferase BF25_5540 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF25_5546 ENOG4105DA5 (ABC) transporter BF25_5548 ENOG4105N5T Radical SAM Protein BF25_555 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_5552 ENOG4105C19 ABC transporter BF25_5555 ENOG4105NCW Trka-c domain protein BF25_5556 ENOG4107S91 Sodium hydrogen exchanger BF25_5557 ENOG410605W Major Facilitator BF25_5563 ENOG4108B31 Spore germination protein BF25_5565 ENOG4105DWV Homoserine O-trans-acetylase BF25_5567 ENOG41085GJ domain protein BF25_5571 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF25_5572 ENOG4105D06 uba thif-type nad fad binding protein BF25_5574 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF25_5575 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF25_5576 ENOG4108ZAF Molybdopterin BF25_5579 ENOG4105CSC Glucose uptake protein BF25_5580 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF25_5581 ENOG4108VJ1 Transcriptional regulator (CarD family BF25_5588 ENOG4105CBX hi0933 family BF25_559 ENOG4105EJQ L-serine dehydratase BF25_5591 ENOG4105YW5 deoR family transcriptional regulator BF25_5592 ENOG4107QSE Dipeptidase BF25_5593 ENOG4107QSE Dipeptidase BF25_5595 ENOG4108IUM Glycogen debranching enzyme BF25_5596 ENOG4108V15 phosphotransferase enzyme family BF25_5599 ENOG4105C8F Beta-lactamase domain protein BF25_560 ENOG4105II7 pyrroline-5-carboxylate reductase BF25_5607 ENOG4105DHF Membrane BF25_562 ENOG41069FQ Metallo-beta-lactamase superfamily BF25_563 ENOG4108IXY short-chain dehydrogenase reductase BF25_5655 ENOG4105CNU cell division protein FtsK BF25_566 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF25_5680 ENOG4105EKQ RNA-directed DNA polymerase BF25_57 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF25_5702 ENOG4105EKQ RNA-directed DNA polymerase BF25_5723 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF25_5730 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF25_5732 ENOG4108MEK Metal-binding protein YodA BF25_5734 ENOG4105DQ6 Transposase BF25_5737 ENOG4105DQ6 Transposase BF25_5739 ENOG4108IBT Inherit from COG: transposase BF25_574 ENOG4105CGH 5'-nucleotidase BF25_5746 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_5748 ENOG4105KRN Transcriptional regulator, abrb family BF25_575 ENOG4105DFD Na H antiporter BF25_577 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF25_5783 ENOG4105DQ6 Transposase BF25_5786 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF25_5787 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF25_579 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF25_5791 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF25_5799 ENOG4105N14 lysine exporter protein LysE YggA BF25_580 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_5807 ENOG4105C3F Signal peptidase i BF25_581 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF25_582 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF25_5825 ENOG4105EWC Purine nucleoside phosphorylase BF25_5832 ENOG4105DQ6 Transposase BF25_5836 ENOG4107QJE Chromosome Partitioning Protein BF25_586 ENOG4108R6K riboflavin synthase, subunit alpha BF25_587 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF25_5870 ENOG4105K4H Nlp p60 protein BF25_5883 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF25_5884 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF25_5894 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF25_591 ENOG4108YM7 Gcn5-related n-acetyltransferase BF25_592 ENOG4105ETE Transcriptional regulator (LacI family BF25_594 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF25_598 ENOG4105RHY Pfam:UPF0157 BF25_600 ENOG4105CPC Aldo Keto reductase BF25_604 ENOG4105MZ9 stage II sporulation protein m BF25_605 ENOG4105I3K Ferric uptake regulator, Fur family BF25_607 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF25_61 ENOG4108JYZ YitT family BF25_612 ENOG4105D7N magnesium and cobalt transport protein CorA BF25_618 ENOG4105DVE abc transporter atp-binding protein BF25_619 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF25_620 ENOG4105DZ1 carboxypeptidase BF25_621 ENOG41082AN stage II sporulation protein BF25_623 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_624 ENOG4105C8J )-transporter BF25_628 ENOG41090VF Stage v sporulation protein ac BF25_629 ENOG4105CZ3 stage V sporulation protein ad BF25_631 ENOG4105G6R Stage v sporulation protein ae BF25_633 ENOG4105J7I hydrolase BF25_634 ENOG4105PTM secreted protein BF25_635 ENOG4107ZE5 PPIases accelerate the folding of proteins BF25_642 ENOG4105CE4 GlcNAc 6-P deacetylase BF25_644 ENOG4105FDP GntR family transcriptional regulator BF25_646 ENOG4105CID antiterminator BF25_649 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF25_653 ENOG4106TD9 Diguanylate cyclase BF25_654 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF25_655 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF25_658 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF25_663 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF25_665 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF25_667 ENOG4105DTD Dehydrogenase BF25_668 ENOG4105K7K Transcriptional regulator BF25_675 ENOG4105CHU acetyl-coa acetyltransferase BF25_684 ENOG4105CG3 alpha amylase, catalytic region BF25_686 ENOG4107FKK extracellular solute-binding protein family 1 BF25_688 ENOG4105EG2 ABC transporter, permease BF25_689 ENOG4105FKQ transcriptional regulator BF25_690 ENOG4105CHM Aminotransferase BF25_692 ENOG4108HGU Histidine kinase BF25_70 ENOG4107YZX Universal stress protein BF25_703 ENOG4105UIN BF25_705 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF25_708 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF25_709 ENOG4105EPM Diguanylate phosphodiesterase BF25_712 ENOG4107IN1 Protein of unknown function (DUF1797) BF25_714 ENOG4108XRC Protein of unknown function (DUF458) BF25_721 ENOG4107ZYR domain protein BF25_722 ENOG4105CN5 Metallo-Beta-Lactamase BF25_724 ENOG4108X4Q Hydrolase BF25_725 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF25_728 ENOG4105CPP Dehydrogenase, E1 component BF25_729 ENOG4105C7S Dehydrogenase BF25_738 ENOG4105CXN decarboxylase BF25_74 ENOG4105VZ8 Transcriptional regulator BF25_742 ENOG4105ECY inositol monophosphatase BF25_744 ENOG4105CI3 gtp-binding protein typa BF25_745 ENOG4105QA2 BF25_749 ENOG4108IAB Phoh family BF25_752 ENOG4105CNI cell division protein FtsW BF25_753 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF25_76 ENOG41082W1 Cupin 2, conserved barrel domain protein BF25_763 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF25_766 ENOG4107TB6 phosphoglycerate mutase BF25_77 ENOG4105Z7P Acetyltransferase (GNAT) family BF25_771 ENOG4106H78 methyltransferase BF25_772 ENOG4105H20 Sporulation integral membrane protein YlbJ BF25_774 ENOG4105D78 K07001 NTE family protein BF25_775 ENOG41063PX domain protein BF25_777 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF25_785 ENOG4108IMY Transcriptional regulator BF25_796 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_799 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF25_816 ENOG4105CAR Terminase, large subunit BF25_818 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF25_836 ENOG4105XSJ toxin secretion phage lysis holin BF25_84 ENOG4105DC7 peptidase M24 BF25_846 ENOG4105KNH Nucleic acid-binding protein BF25_853 ENOG41068DC Essential cell division protein (By similarity) BF25_854 ENOG4105CJN penicillin-binding protein BF25_855 ENOG4105CJN penicillin-binding protein BF25_856 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF25_859 ENOG4105CNI cell division protein FtsW BF25_860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF25_861 ENOG4105D4A Cell wall formation (By similarity) BF25_862 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF25_863 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF25_864 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF25_866 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF25_868 ENOG4105WR5 sporulation protein, YlmC YmxH family BF25_869 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF25_870 ENOG4105DFA alanine racemase domain protein BF25_872 ENOG41067XK integral membrane protein BF25_873 ENOG4105DBK s4 domain protein BF25_875 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF25_878 ENOG4105C34 Pseudouridine synthase BF25_883 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF25_894 ENOG4105DC7 peptidase M24 BF25_895 ENOG4105F23 Fibronectin-binding protein BF25_897 ENOG4105DSJ YicC domain protein BF25_901 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF25_902 ENOG4105C25 Primosomal protein n' BF25_903 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF25_905 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF25_907 ENOG4108ZF3 Phosphatase BF25_908 ENOG4105D9P serine threonine protein kinase BF25_909 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF25_91 ENOG4105SFS phosphoesterase RecJ domain protein BF25_910 ENOG4105DJV ribulose-phosphate 3-epimerase BF25_911 ENOG4105FJ0 thiamine BF25_913 ENOG4108ZAA Alkaline-shock protein BF25_914 ENOG4105DP4 dak2 domain fusion protein ylov BF25_915 ENOG4105CB5 ATP-dependent DNA helicase recG BF25_918 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF25_919 ENOG4105CHR reductase BF25_922 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF25_923 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF25_927 ENOG4105VB6 UPF0109 protein BF25_93 ENOG4105VV2 BF25_932 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF25_935 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF25_937 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF25_939 ENOG4108HE4 integrase family BF25_94 ENOG4105C0B DNA polymerase III (alpha subunit) BF25_947 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF25_948 ENOG4105KNE Phosphatidate cytidylyltransferase BF25_949 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF25_95 ENOG4105C6K Malic enzyme BF25_950 ENOG4105DZP Membrane-associated zinc metalloprotease BF25_952 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF25_954 ENOG4105CHV Transcription elongation factor NusA BF25_955 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF25_956 ENOG4105VHM ribosomal protein BF25_958 ENOG4105W7A Protein of unknown function (DUF503) BF25_96 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF25_960 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF25_961 ENOG4105DTN riboflavin biosynthesis protein ribF BF25_965 ENOG4105C1V Peptidase, M16 BF25_967 ENOG4105E35 Dipicolinate synthase subunit A BF25_968 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF25_969 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF25_971 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF25_973 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF25_975 ENOG4107QZI cell division protein FtsK BF25_976 ENOG4105FDP GntR family transcriptional regulator BF25_977 ENOG4105DIH basic membrane BF25_978 ENOG4108JQ9 ABC transporter BF25_979 ENOG4105UIB (ABC) transporter BF25_980 ENOG4105UIB (ABC) transporter BF25_984 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF25_985 ENOG4105XZV Protein of unknown function (DUF3243) BF25_988 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF25_993 ENOG4105D48 metallophosphoesterase BF25_994 ENOG4105MCT stage V sporulation protein S BF25_995 ENOG4108IGT Dipeptidase BF25_996 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF25_997 ENOG4105DQU oxidoreductase, subunit beta BF25_998 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)