locus-tag	class	description
BF25_1	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BF25_1008	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BF25_101	COG3030	protein affecting phage T7 exclusion by the F plasmid
BF25_1010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF25_1011	COG1368	sulfuric ester hydrolase activity
BF25_1012	COG0562	UDP-galactopyranose mutase
BF25_1013	COG3773	Cell wall hydrolase
BF25_1014	COG1404	Belongs to the peptidase S8 family
BF25_1017	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BF25_1018	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF25_1018	COG0596	Alpha beta hydrolase
BF25_1019	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_102	COG0628	permease
BF25_1020	COG1380	Effector of murein hydrolase LrgA
BF25_1021	COG1346	cytolysis
BF25_1024	COG5001	Diguanylate cyclase
BF25_1024	COG3300	MHYT domain
BF25_1025	COG0346	lactoylglutathione lyase activity
BF25_1026	COG2267	carboxylic ester hydrolase activity
BF25_1029	COG2364	Membrane
BF25_1031	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BF25_1032	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BF25_1033	COG2169	Transcriptional regulator
BF25_1034	COG0708	Exodeoxyribonuclease III
BF25_1036	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_1037	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_1038	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_1039	COG1120	ATPase activity
BF25_104	COG0372	Belongs to the citrate synthase family
BF25_1040	COG2819	hydrolase of the alpha beta superfamily
BF25_1042	COG1937	Protein conserved in bacteria
BF25_1043	COG2608	mercury ion transmembrane transporter activity
BF25_1044	COG2217	Heavy metal translocating P-type atpase
BF25_1046	COG2116	formate transmembrane transporter activity
BF25_1047	COG1408	metallophosphoesterase
BF25_105	COG0538	isocitrate dehydrogenase activity
BF25_1050	COG1113	amino acid transport
BF25_1053	COG2322	membrane
BF25_1054	COG1979	alcohol dehydrogenase
BF25_1055	COG1979	alcohol dehydrogenase
BF25_1056	COG1349	DNA-binding transcription factor activity
BF25_1057	COG1105	Belongs to the carbohydrate kinase PfkB family
BF25_1058	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF25_1058	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BF25_1058	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BF25_1059	COG3584	3D domain protein
BF25_1059	COG1388	LysM domain
BF25_1066	COG0464	growth
BF25_1067	COG2860	membrane
BF25_1068	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF25_1069	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF25_1070	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BF25_1071	COG0789	Transcriptional regulator
BF25_1072	COG0174	glutamine synthetase
BF25_1077	COG1396	sequence-specific DNA binding
BF25_109	COG0745	RESPONSE REGULATOR receiver
BF25_1093	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BF25_110	COG5002	protein histidine kinase activity
BF25_1101	COG1595	DNA-templated transcription, initiation
BF25_111	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF25_111	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF25_112	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BF25_113	COG1971	Probably functions as a manganese efflux pump
BF25_1133	COG4824	toxin secretion phage lysis holin
BF25_1134	COG1388	LysM domain
BF25_1134	COG3409	Peptidoglycan-binding domain 1 protein
BF25_1134	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF25_114	COG0237	dephospho-CoA kinase activity
BF25_1142	COG1695	Transcriptional regulator
BF25_1146	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BF25_1148	COG0737	Belongs to the 5'-nucleotidase family
BF25_115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BF25_1151	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BF25_1152	COG3639	organic phosphonate transmembrane transporter activity
BF25_1158	COG1132	(ABC) transporter
BF25_1159	COG1132	(ABC) transporter
BF25_116	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BF25_1162	COG3409	Peptidoglycan-binding domain 1 protein
BF25_1162	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF25_1164	COG0730	response to heat
BF25_1167	COG1346	cytolysis
BF25_1168	COG1380	Effector of murein hydrolase LrgA
BF25_1169	COG0583	DNA-binding transcription factor activity
BF25_1171	COG0785	Cytochrome C biogenesis protein
BF25_1172	COG4846	Membrane protein involved in cytochrome C biogenesis
BF25_118	COG3611	Membrane attachment protein
BF25_1182	COG2226	methyltransferase
BF25_1187	COG0010	Belongs to the arginase family
BF25_1188	COG1329	Transcriptional regulator
BF25_1189	COG1902	pentaerythritol trinitrate reductase activity
BF25_119	COG1484	DNA-dependent DNA replication
BF25_1190	COG0069	glutamate synthase activity
BF25_1191	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF25_1192	COG0346	lactoylglutathione lyase activity
BF25_1193	COG0400	carboxylic ester hydrolase activity
BF25_1194	COG5002	protein histidine kinase activity
BF25_1196	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_1205	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_1206	COG1268	BioY protein
BF25_1207	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_1208	COG0183	Belongs to the thiolase family
BF25_121	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF25_1211	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF25_1213	COG2211	Major facilitator Superfamily
BF25_1216	COG0726	polysaccharide deacetylase
BF25_1218	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BF25_1219	COG2274	protein secretion by the type I secretion system
BF25_122	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BF25_1221	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF25_1227	COG0824	Thioesterase
BF25_1228	COG4841	protein insertion into membrane
BF25_1229	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BF25_1232	COG0745	RESPONSE REGULATOR receiver
BF25_1233	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF25_1234	COG1832	CoA-binding protein
BF25_1235	COG0187	DNA topoisomerase II activity
BF25_1236	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BF25_1237	COG0673	inositol 2-dehydrogenase activity
BF25_1239	COG1131	(ABC) transporter
BF25_1243	COG1595	DNA-templated transcription, initiation
BF25_1245	COG1316	TRANSCRIPTIONal
BF25_1248	COG4166	transmembrane transport
BF25_1249	COG4166	transmembrane transport
BF25_1250	COG4166	transmembrane transport
BF25_1251	COG2226	methyltransferase
BF25_1259	COG0697	spore germination
BF25_126	COG1363	Peptidase, m42
BF25_1261	COG3383	formate dehydrogenase (NAD+) activity
BF25_1262	COG2427	Protein of unknown function (DUF1641)
BF25_1263	COG5609	conserved protein (DUF2294)
BF25_1264	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BF25_1266	COG2116	formate transmembrane transporter activity
BF25_1267	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF25_1268	COG0303	'Molybdopterin
BF25_1269	COG0314	molybdopterin synthase activity
BF25_127	COG1309	transcriptional regulator
BF25_1271	COG0489	protein tyrosine kinase activity
BF25_1274	COG3326	Membrane
BF25_1275	COG2962	Rard protein
BF25_1276	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BF25_1277	COG1657	PFAM Prenyltransferase squalene oxidase
BF25_1279	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_128	COG1566	PFAM secretion protein HlyD family protein
BF25_1280	COG1012	belongs to the aldehyde dehydrogenase family
BF25_1282	COG4145	pantothenate transmembrane transporter activity
BF25_1285	COG0165	Argininosuccinate lyase
BF25_1287	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_129	COG2814	Major facilitator Superfamily
BF25_1293	COG0716	FMN binding
BF25_1295	COG1278	Cold shock
BF25_13	COG2309	aminopeptidase activity
BF25_1301	COG2720	vancomycin resistance protein
BF25_1302	COG2514	catechol 2,3-dioxygenase activity
BF25_1304	COG1285	pathogenesis
BF25_1306	COG1024	Enoyl-CoA hydratase
BF25_1307	COG1216	Glycosyl transferase, family 2
BF25_1313	COG0277	FAD linked oxidase domain protein
BF25_1314	COG0385	Bile acid
BF25_1316	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF25_1317	COG2808	Putative FMN-binding domain
BF25_1320	COG0457	Tetratricopeptide repeat
BF25_1322	COG0604	alcohol dehydrogenase
BF25_1323	COG0640	Transcriptional regulator
BF25_1327	COG0584	glycerophosphoryl diester phosphodiesterase
BF25_1333	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF25_1334	COG1164	Oligoendopeptidase f
BF25_1335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BF25_1338	COG1193	negative regulation of DNA recombination
BF25_134	COG1418	mRNA catabolic process
BF25_1342	COG0583	DNA-binding transcription factor activity
BF25_1348	COG0384	phenazine biosynthesis protein PhzF
BF25_1349	COG3739	integral membrane protein
BF25_1350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_1351	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_1353	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_1357	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF25_1358	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BF25_136	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF25_1364	COG2814	Major facilitator Superfamily
BF25_1365	COG1113	amino acid transport
BF25_1366	COG0604	alcohol dehydrogenase
BF25_1367	COG0604	alcohol dehydrogenase
BF25_1374	COG2072	flavoprotein involved in K transport
BF25_138	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_138	COG0072	phenylalanine-tRNA ligase activity
BF25_1381	COG3757	hydrolase, family 25
BF25_1381	COG3409	Peptidoglycan-binding domain 1 protein
BF25_1382	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_1385	COG1151	hydroxylamine reductase activity
BF25_139	COG0017	Asparaginyl-tRNA synthetase
BF25_1390	COG3152	Membrane
BF25_1394	COG1309	transcriptional regulator
BF25_1397	COG1191	sigma factor activity
BF25_1400	COG0726	polysaccharide deacetylase
BF25_1404	COG1733	regulation of RNA biosynthetic process
BF25_1405	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF25_1407	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_1409	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_1411	COG0384	phenazine biosynthesis protein PhzF
BF25_1415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_1418	COG1733	regulation of RNA biosynthetic process
BF25_1419	COG1733	regulation of RNA biosynthetic process
BF25_1420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BF25_1422	COG0673	inositol 2-dehydrogenase activity
BF25_1423	COG2188	Transcriptional regulator
BF25_1424	COG1733	regulation of RNA biosynthetic process
BF25_1425	COG1393	Belongs to the ArsC family
BF25_1430	COG0814	amino acid
BF25_1431	COG0346	lactoylglutathione lyase activity
BF25_1434	COG2814	Major facilitator Superfamily
BF25_1435	COG0656	L-ascorbic acid biosynthetic process
BF25_1440	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_1443	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BF25_1444	COG0604	alcohol dehydrogenase
BF25_1445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BF25_1446	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BF25_1448	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BF25_1449	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BF25_145	COG1286	toxin biosynthetic process
BF25_1451	COG1070	Carbohydrate kinase
BF25_1452	COG2706	6-phosphogluconolactonase activity
BF25_1453	COG3813	Protein conserved in bacteria
BF25_1454	COG1357	PFAM Pentapeptide repeats (8 copies)
BF25_1455	COG0697	spore germination
BF25_1456	COG0789	Transcriptional regulator
BF25_1457	COG1253	flavin adenine dinucleotide binding
BF25_146	COG1796	DNA polymerase
BF25_146	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BF25_1463	COG0477	Major facilitator Superfamily
BF25_1465	COG2226	methyltransferase
BF25_1469	COG0628	permease
BF25_1470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BF25_1471	COG0180	Tryptophanyl-tRNA synthetase
BF25_1473	COG1136	(ABC) transporter
BF25_1476	COG0110	maltose O-acetyltransferase activity
BF25_1477	COG0738	Major facilitator superfamily
BF25_1478	COG1940	carbohydrate kinase activity
BF25_1479	COG0346	lactoylglutathione lyase activity
BF25_1486	COG1011	Hydrolase
BF25_149	COG1187	pseudouridine synthase activity
BF25_1491	COG1131	(ABC) transporter
BF25_1493	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_1497	COG0778	Nitroreductase
BF25_1498	COG1733	regulation of RNA biosynthetic process
BF25_15	COG3118	belongs to the thioredoxin family
BF25_150	COG1114	Component of the transport system for branched-chain amino acids
BF25_1501	COG0124	histidyl-tRNA synthetase
BF25_1502	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BF25_1503	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BF25_1504	COG3620	sequence-specific DNA binding
BF25_1507	COG2356	endonuclease I
BF25_1508	COG1288	antiporter activity
BF25_1509	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BF25_151	COG5386	Cell surface protein
BF25_1512	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BF25_1513	COG1122	ATPase activity
BF25_1519	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF25_1521	COG2031	fatty acid transporter
BF25_1523	COG1309	transcriptional regulator
BF25_1524	COG2076	Multidrug Resistance protein
BF25_1528	COG1131	(ABC) transporter
BF25_1529	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BF25_153	COG5386	Cell surface protein
BF25_1532	COG2814	Major facilitator Superfamily
BF25_1533	COG1846	Transcriptional regulator
BF25_1535	COG0477	Major facilitator Superfamily
BF25_1546	COG2207	Transcriptional regulator
BF25_1546	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_1547	COG0662	Cupin 2, conserved barrel domain protein
BF25_1550	COG1595	DNA-templated transcription, initiation
BF25_1554	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BF25_1557	COG0531	amino acid
BF25_1558	COG1522	sequence-specific DNA binding
BF25_1559	COG1335	isochorismatase
BF25_156	COG1120	ATPase activity
BF25_1561	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BF25_1562	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BF25_1563	COG1760	l-serine dehydratase
BF25_1564	COG1760	l-serine dehydratase
BF25_1565	COG0814	amino acid
BF25_1568	COG1309	transcriptional regulator
BF25_1569	COG2814	Major facilitator Superfamily
BF25_157	COG4509	Sortase family
BF25_1570	COG2184	nucleotidyltransferase activity
BF25_1573	COG0534	Mate efflux family protein
BF25_1580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BF25_1584	COG0457	Tetratricopeptide repeat
BF25_1585	COG1609	Transcriptional regulator
BF25_1586	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF25_1587	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BF25_1588	COG0561	phosphatase activity
BF25_1589	COG0673	inositol 2-dehydrogenase activity
BF25_1590	COG0738	Major facilitator superfamily
BF25_1594	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF25_1596	COG0583	DNA-binding transcription factor activity
BF25_1598	COG1139	Iron-sulfur cluster binding protein
BF25_1599	COG1556	Lactate utilization protein
BF25_16	COG4851	CamS sex pheromone cAM373 precursor
BF25_160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BF25_1600	COG2271	Major facilitator Superfamily
BF25_1601	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_1602	COG2808	Putative FMN-binding domain
BF25_1603	COG0456	acetyltransferase
BF25_1604	COG1846	Transcriptional regulator
BF25_1605	COG2364	Membrane
BF25_1607	COG3850	Histidine kinase
BF25_1607	COG5002	protein histidine kinase activity
BF25_161	COG4895	conserved protein (DUF2196)
BF25_1610	COG0577	efflux transmembrane transporter activity
BF25_1611	COG1136	(ABC) transporter
BF25_1614	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BF25_1615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_1617	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF25_1618	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_1621	COG1476	TRANSCRIPTIONal
BF25_1627	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BF25_163	COG0745	RESPONSE REGULATOR receiver
BF25_1632	COG5002	protein histidine kinase activity
BF25_1632	COG3850	Histidine kinase
BF25_1633	COG0745	RESPONSE REGULATOR receiver
BF25_1638	COG2814	Major facilitator Superfamily
BF25_164	COG2205	protein histidine kinase activity
BF25_165	COG1131	(ABC) transporter
BF25_1650	COG0346	lactoylglutathione lyase activity
BF25_1653	COG1522	sequence-specific DNA binding
BF25_1656	COG0443	Heat shock 70 kDa protein
BF25_1660	COG0640	Transcriptional regulator
BF25_1661	COG0346	lactoylglutathione lyase activity
BF25_1662	COG0798	PFAM Bile acid sodium symporter
BF25_1668	COG1121	(ABC) transporter
BF25_1669	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BF25_1670	COG0803	Belongs to the bacterial solute-binding protein 9 family
BF25_1671	COG2267	carboxylic ester hydrolase activity
BF25_1672	COG1575	Belongs to the MenA family. Type 1 subfamily
BF25_1674	COG5609	conserved protein (DUF2294)
BF25_1675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF25_1677	COG0288	reversible hydration of carbon dioxide
BF25_1678	COG0415	Belongs to the DNA photolyase family
BF25_1685	COG0598	Magnesium transport protein CorA
BF25_1686	COG0598	Magnesium transport protein CorA
BF25_1687	COG1846	Transcriptional regulator
BF25_1688	COG0583	DNA-binding transcription factor activity
BF25_1693	COG1335	isochorismatase
BF25_1694	COG2267	carboxylic ester hydrolase activity
BF25_1695	COG0753	catalase activity
BF25_1696	COG0737	Belongs to the 5'-nucleotidase family
BF25_17	COG1609	Transcriptional regulator
BF25_1705	COG2066	Belongs to the glutaminase family
BF25_1708	COG0784	Response regulator, receiver
BF25_1709	COG0697	spore germination
BF25_171	COG2318	DinB family
BF25_1716	COG0281	malic enzyme
BF25_1718	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF25_1719	COG1114	Component of the transport system for branched-chain amino acids
BF25_1720	COG0531	amino acid
BF25_1721	COG0322	excinuclease ABC activity
BF25_1723	COG1396	sequence-specific DNA binding
BF25_1724	COG0252	asparaginase activity
BF25_1725	COG1027	Aspartate ammonia-lyase
BF25_1728	COG1063	alcohol dehydrogenase
BF25_1734	COG1113	amino acid transport
BF25_1735	COG1113	amino acid transport
BF25_1736	COG1280	lysine exporter protein (LysE YggA)
BF25_1737	COG3403	YqcI/YcgG family
BF25_1739	COG5577	PFAM Coat F domain
BF25_1742	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_1743	COG0574	Belongs to the PEP-utilizing enzyme family
BF25_1743	COG3848	Pyruvate phosphate dikinase
BF25_1746	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BF25_175	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_1753	COG1960	acyl-CoA dehydrogenase activity
BF25_1755	COG0640	Transcriptional regulator
BF25_1756	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF25_1759	COG1414	Transcriptional regulator
BF25_176	COG1309	transcriptional regulator
BF25_1760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BF25_1761	COG1984	allophanate hydrolase subunit 2
BF25_1768	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BF25_177	COG1024	Enoyl-CoA hydratase
BF25_1778	COG4335	DNA alkylation repair
BF25_178	COG2086	electron transfer activity
BF25_1780	COG0833	amino acid
BF25_1782	COG0730	response to heat
BF25_1788	COG0596	Alpha beta hydrolase
BF25_1789	COG0745	RESPONSE REGULATOR receiver
BF25_179	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BF25_1790	COG0642	Histidine kinase
BF25_1794	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_1798	COG0456	acetyltransferase
BF25_1799	COG2207	Transcriptional regulator
BF25_180	COG3118	belongs to the thioredoxin family
BF25_1804	COG0577	efflux transmembrane transporter activity
BF25_1804	COG1136	(ABC) transporter
BF25_1806	COG1725	Transcriptional regulator
BF25_1813	COG1846	Transcriptional regulator
BF25_1814	COG0778	Nitroreductase
BF25_1816	COG0714	Associated with various cellular activities
BF25_182	COG1719	4-vinyl reductase, 4VR
BF25_1822	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BF25_1824	COG0753	catalase activity
BF25_1825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF25_1827	COG0463	Glycosyl transferase, family 2
BF25_183	COG2009	succinate dehydrogenase
BF25_1832	COG0463	Glycosyl transferase, family 2
BF25_1837	COG0714	Associated with various cellular activities
BF25_184	COG1053	succinate dehydrogenase
BF25_1841	COG0346	lactoylglutathione lyase activity
BF25_1842	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_1844	COG3279	Response regulator of the LytR AlgR family
BF25_1846	COG4377	Putative membrane peptidase family (DUF2324)
BF25_1849	COG3655	Transcriptional regulator
BF25_185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BF25_1851	COG1785	Belongs to the alkaline phosphatase family
BF25_1852	COG3239	Fatty acid desaturase
BF25_1853	COG1690	Belongs to the RtcB family
BF25_1854	COG0833	amino acid
BF25_1855	COG1414	Transcriptional regulator
BF25_1856	COG4187	Peptidase family M20/M25/M40
BF25_1857	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF25_1858	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BF25_186	COG0824	Thioesterase
BF25_1860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_1864	COG2329	Antibiotic biosynthesis monooxygenase
BF25_187	COG1876	peptidase activity
BF25_1872	COG1070	Carbohydrate kinase
BF25_1873	COG2390	Transcriptional regulator
BF25_1875	COG1172	Belongs to the binding-protein-dependent transport system permease family
BF25_1877	COG1879	ABC-type sugar transport system periplasmic component
BF25_188	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BF25_1883	COG1595	DNA-templated transcription, initiation
BF25_1885	COG3584	3D domain protein
BF25_1885	COG1388	LysM domain
BF25_189	COG1360	Flagellar Motor Protein
BF25_1893	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BF25_1893	COG1605	Chorismate mutase
BF25_1894	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BF25_1895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BF25_1896	COG0287	Prephenate dehydrogenase
BF25_1899	COG1309	transcriptional regulator
BF25_190	COG1360	Flagellar Motor Protein
BF25_1900	COG2409	Drug exporters of the RND superfamily
BF25_1900	COG1033	growth of symbiont in host cell
BF25_1901	COG1033	growth of symbiont in host cell
BF25_1901	COG2409	Drug exporters of the RND superfamily
BF25_1903	COG0488	(ABC) transporter
BF25_1904	COG1368	sulfuric ester hydrolase activity
BF25_1905	COG0861	Integral membrane protein TerC family
BF25_1907	COG0726	polysaccharide deacetylase
BF25_1909	COG4912	Dna alkylation repair
BF25_191	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BF25_1913	COG2318	DinB family
BF25_1914	COG0697	spore germination
BF25_1919	COG2746	aminoglycoside 3-N-acetyltransferase activity
BF25_192	COG4152	abc transporter atp-binding protein
BF25_1927	COG1116	anion transmembrane transporter activity
BF25_1928	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF25_1929	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF25_193	COG1668	transmembrane transport
BF25_1930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BF25_1932	COG0628	permease
BF25_194	COG1959	2 iron, 2 sulfur cluster binding
BF25_1941	COG1131	(ABC) transporter
BF25_1946	COG5146	pantothenate kinase activity
BF25_1947	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BF25_1948	COG0436	Aminotransferase
BF25_1954	COG2226	methyltransferase
BF25_1957	COG2261	transglycosylase associated protein
BF25_196	COG0697	spore germination
BF25_1961	COG0477	Major facilitator Superfamily
BF25_1961	COG2814	Major facilitator Superfamily
BF25_1962	COG4533	DNA binding
BF25_1963	COG0789	Transcriptional regulator
BF25_1964	COG1664	Polymer-forming cytoskeletal
BF25_1966	COG2814	Major facilitator Superfamily
BF25_197	COG1396	sequence-specific DNA binding
BF25_1970	COG1307	EDD domain protein, DegV family
BF25_1973	COG1164	Oligoendopeptidase f
BF25_198	COG1983	PspC domain protein
BF25_1980	COG0745	RESPONSE REGULATOR receiver
BF25_1981	COG5002	protein histidine kinase activity
BF25_1982	COG2936	dipeptidyl-peptidase activity
BF25_1990	COG4948	Mandelate Racemase Muconate Lactonizing
BF25_1992	COG4166	transmembrane transport
BF25_1993	COG0519	Catalyzes the synthesis of GMP from XMP
BF25_1994	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BF25_1997	COG0586	Pfam SNARE associated Golgi protein
BF25_2	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF25_2004	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF25_2005	COG3938	Belongs to the proline racemase family
BF25_2007	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BF25_2008	COG1012	belongs to the aldehyde dehydrogenase family
BF25_2009	COG1115	amino acid carrier protein
BF25_201	COG3279	Response regulator of the LytR AlgR family
BF25_2010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BF25_2012	COG3397	chitin binding
BF25_2017	COG4637	Psort location Cytoplasmic, score
BF25_202	COG3275	phosphorelay sensor kinase activity
BF25_2020	COG0514	ATP-dependent DNA helicase (RecQ)
BF25_2021	COG2105	PFAM AIG2 family protein
BF25_2024	COG3973	AAA domain
BF25_203	COG4608	Belongs to the ABC transporter superfamily
BF25_2035	COG0658	competence protein
BF25_2035	COG2333	competence protein COMEC
BF25_204	COG0444	Belongs to the ABC transporter superfamily
BF25_2040	COG2205	protein histidine kinase activity
BF25_2044	COG3397	chitin binding
BF25_2045	COG2153	protein acetylation
BF25_2046	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BF25_2049	COG0740	serine-type endopeptidase activity
BF25_2051	COG0517	IMP dehydrogenase activity
BF25_2051	COG4175	Glycine betaine
BF25_2052	COG4176	ABC-type proline glycine betaine transport system permease component
BF25_2058	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF25_2058	COG0456	acetyltransferase
BF25_2059	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_2061	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF25_2062	COG0022	dehydrogenase e1 component
BF25_2063	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF25_2064	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF25_2068	COG1959	2 iron, 2 sulfur cluster binding
BF25_2072	COG1349	DNA-binding transcription factor activity
BF25_2076	COG3284	Transcriptional regulator
BF25_208	COG0402	S-adenosylhomocysteine deaminase activity
BF25_2082	COG1309	transcriptional regulator
BF25_2083	COG3844	kynureninase activity
BF25_2084	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BF25_2085	COG3483	tryptophan 2,3-dioxygenase activity
BF25_2088	COG3409	Peptidoglycan-binding domain 1 protein
BF25_2088	COG3773	Cell wall hydrolase
BF25_2089	COG2959	enzyme of heme biosynthesis
BF25_209	COG0402	S-adenosylhomocysteine deaminase activity
BF25_2092	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_2093	COG4129	membrane
BF25_2099	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2100	COG0697	spore germination
BF25_2102	COG0201	protein transport
BF25_2106	COG3227	Zinc metalloprotease (Elastase)
BF25_2107	COG1523	belongs to the glycosyl hydrolase 13 family
BF25_211	COG2233	PERMEase
BF25_2111	COG0076	glutamate decarboxylase activity
BF25_2116	COG1011	Hydrolase
BF25_212	COG2197	response regulator
BF25_2121	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF25_2129	COG0322	excinuclease ABC activity
BF25_2133	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BF25_2138	COG4667	esterase of the alpha-beta hydrolase superfamily
BF25_2144	COG3878	Protein conserved in bacteria
BF25_215	COG1309	transcriptional regulator
BF25_2151	COG1051	belongs to the nudix hydrolase family
BF25_2152	COG0592	DNA-directed DNA polymerase activity
BF25_2153	COG2816	NAD+ diphosphatase activity
BF25_2155	COG2223	nitrite transmembrane transporter activity
BF25_2162	COG0697	spore germination
BF25_2163	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2164	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2167	COG0584	glycerophosphoryl diester phosphodiesterase
BF25_2171	COG2814	Major facilitator Superfamily
BF25_2176	COG0693	protein deglycase activity
BF25_2182	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF25_2185	COG0604	alcohol dehydrogenase
BF25_2188	COG2205	protein histidine kinase activity
BF25_219	COG5401	PFAM Sporulation and spore germination
BF25_2191	COG1122	ATPase activity
BF25_2193	COG1794	racemase activity, acting on amino acids and derivatives
BF25_2194	COG1819	glycosyl
BF25_2196	COG5002	protein histidine kinase activity
BF25_2198	COG0561	phosphatase activity
BF25_2205	COG2124	cytochrome p450
BF25_221	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BF25_222	COG0622	Phosphoesterase
BF25_2221	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BF25_2223	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2224	COG0460	homoserine dehydrogenase
BF25_2228	COG0577	efflux transmembrane transporter activity
BF25_2229	COG0577	efflux transmembrane transporter activity
BF25_2230	COG1136	(ABC) transporter
BF25_2236	COG2205	protein histidine kinase activity
BF25_2238	COG0745	RESPONSE REGULATOR receiver
BF25_2240	COG3773	Cell wall hydrolase
BF25_2243	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF25_2244	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF25_2247	COG1063	alcohol dehydrogenase
BF25_2249	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2253	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BF25_2257	COG2814	Major facilitator Superfamily
BF25_2259	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF25_2262	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BF25_2262	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BF25_2267	COG3227	Zinc metalloprotease (Elastase)
BF25_2271	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BF25_2276	COG1686	Belongs to the peptidase S11 family
BF25_2277	COG2318	DinB family
BF25_2279	COG0572	uridine kinase
BF25_2280	COG1247	-acetyltransferase
BF25_2282	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF25_2283	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BF25_2284	COG1024	Enoyl-CoA hydratase
BF25_2285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BF25_2286	COG0511	ligase activity, forming carbon-carbon bonds
BF25_2287	COG0439	Biotin carboxylase
BF25_2288	COG1960	acyl-CoA dehydrogenase activity
BF25_2291	COG1309	transcriptional regulator
BF25_2293	COG1131	(ABC) transporter
BF25_2296	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_2297	COG1252	NADH dehydrogenase
BF25_2299	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_2303	COG1309	transcriptional regulator
BF25_2308	COG1876	peptidase activity
BF25_2311	COG1476	TRANSCRIPTIONal
BF25_2312	COG0457	Tetratricopeptide repeat
BF25_2314	COG0737	Belongs to the 5'-nucleotidase family
BF25_2315	COG0737	Belongs to the 5'-nucleotidase family
BF25_2319	COG3718	enzyme involved in inositol metabolism
BF25_232	COG0470	DNA polymerase III
BF25_232	COG1067	ATP-dependent peptidase activity
BF25_2324	COG1012	belongs to the aldehyde dehydrogenase family
BF25_2326	COG0673	inositol 2-dehydrogenase activity
BF25_2327	COG2814	Major facilitator Superfamily
BF25_2328	COG1609	Transcriptional regulator
BF25_2329	COG0671	phosphoesterase, PA-phosphatase related
BF25_2330	COG2367	Beta-lactamase
BF25_2333	COG0768	penicillin binding
BF25_2335	COG1595	DNA-templated transcription, initiation
BF25_2339	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF25_2347	COG1846	Transcriptional regulator
BF25_2348	COG3961	Belongs to the TPP enzyme family
BF25_2349	COG2226	methyltransferase
BF25_235	COG1764	response to oxidative stress
BF25_2351	COG3615	Tellurite resistance protein tehB
BF25_2351	COG0500	methyltransferase
BF25_2352	COG0577	efflux transmembrane transporter activity
BF25_2352	COG1136	(ABC) transporter
BF25_2355	COG1309	transcriptional regulator
BF25_236	COG1846	Transcriptional regulator
BF25_2360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_2363	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BF25_2364	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BF25_2365	COG2971	BadF BadG BcrA BcrD
BF25_2371	COG1649	PFAM Uncharacterised BCR, COG1649
BF25_2376	COG1595	DNA-templated transcription, initiation
BF25_238	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF25_2381	COG1396	sequence-specific DNA binding
BF25_2385	COG1132	(ABC) transporter
BF25_2386	COG1132	(ABC) transporter
BF25_2389	COG2258	MOSC domain
BF25_2390	COG0583	DNA-binding transcription factor activity
BF25_2393	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF25_2394	COG0583	DNA-binding transcription factor activity
BF25_24	COG0666	response to abiotic stimulus
BF25_240	COG1587	Uroporphyrinogen-III synthase
BF25_2402	COG0561	phosphatase activity
BF25_2403	COG0010	Belongs to the arginase family
BF25_2406	COG1278	Cold shock
BF25_2408	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_241	COG0113	porphobilinogen synthase activity
BF25_2416	COG1247	-acetyltransferase
BF25_2423	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_243	COG1388	LysM domain
BF25_2432	COG2226	methyltransferase
BF25_2437	COG2814	Major facilitator Superfamily
BF25_2438	COG0596	Alpha beta hydrolase
BF25_2442	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF25_2443	COG1187	pseudouridine synthase activity
BF25_2444	COG2329	Antibiotic biosynthesis monooxygenase
BF25_2447	COG1115	amino acid carrier protein
BF25_2449	COG2318	DinB family
BF25_245	COG0525	valine-tRNA ligase activity
BF25_2451	COG0776	regulation of translation
BF25_2454	COG2814	Major facilitator Superfamily
BF25_2455	COG3251	PFAM MbtH domain protein
BF25_2456	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BF25_2457	COG1535	isochorismatase
BF25_2457	COG3433	isochorismatase activity
BF25_2458	COG1021	2,3-dihydroxybenzoate-AMP ligase
BF25_2459	COG1169	isochorismate synthase
BF25_246	COG0285	dihydrofolate synthase activity
BF25_2460	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_2461	COG2223	nitrite transmembrane transporter activity
BF25_2465	COG0419	ATPase involved in DNA repair
BF25_2466	COG0420	3'-5' exonuclease activity
BF25_2469	COG1024	Enoyl-CoA hydratase
BF25_2470	COG1280	lysine exporter protein (LysE YggA)
BF25_2471	COG1012	belongs to the aldehyde dehydrogenase family
BF25_2472	COG2084	Dehydrogenase
BF25_2473	COG1960	acyl-CoA dehydrogenase activity
BF25_2474	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BF25_2475	COG2079	MmgE PrpD family protein
BF25_2476	COG0372	Belongs to the citrate synthase family
BF25_2477	COG4841	protein insertion into membrane
BF25_2478	COG2814	Major facilitator Superfamily
BF25_2479	COG4499	WXG100 protein secretion system (Wss), protein YukC
BF25_2479	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF25_2487	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF25_250	COG1077	Cell shape determining protein MreB Mrl
BF25_2503	COG1715	Restriction endonuclease
BF25_2503	COG1787	Restriction endonuclease
BF25_2508	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF25_2509	COG0671	phosphoesterase, PA-phosphatase related
BF25_251	COG1792	Involved in formation and maintenance of cell shape
BF25_2510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF25_2511	COG4326	sporulation control protein
BF25_2519	COG1509	lysine 2,3-aminomutase activity
BF25_2520	COG3829	transcription factor binding
BF25_2521	COG0456	acetyltransferase
BF25_2522	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF25_2523	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BF25_2524	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BF25_2525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF25_2528	COG5506	Protein of unknown function (DUF1694)
BF25_2529	COG1012	belongs to the aldehyde dehydrogenase family
BF25_2530	COG1253	flavin adenine dinucleotide binding
BF25_2537	COG1174	glycine betaine transport
BF25_2538	COG0517	IMP dehydrogenase activity
BF25_2538	COG1125	glycine betaine transport
BF25_254	COG2894	cell division
BF25_2545	COG1070	Carbohydrate kinase
BF25_255	COG0739	heme binding
BF25_2552	COG1064	alcohol dehydrogenase
BF25_2553	COG1737	Transcriptional regulator
BF25_2555	COG2197	response regulator
BF25_2556	COG2203	Gaf domain
BF25_2556	COG4585	Histidine kinase
BF25_2557	COG0668	transmembrane transport
BF25_2559	COG1051	belongs to the nudix hydrolase family
BF25_256	COG1994	Peptidase M50
BF25_2560	COG1335	isochorismatase
BF25_2564	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF25_2565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_2569	COG0367	asparagine synthase
BF25_257	COG1530	ribonuclease E activity
BF25_2570	COG0071	Belongs to the small heat shock protein (HSP20) family
BF25_2571	COG1999	signal sequence binding
BF25_2572	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BF25_2573	COG1307	EDD domain protein, DegV family
BF25_2575	COG0805	protein transport
BF25_2577	COG1272	protein, Hemolysin III
BF25_2578	COG0204	Acyl-transferase
BF25_2579	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BF25_2580	COG0768	penicillin binding
BF25_2583	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF25_2587	COG0546	phosphoglycolate phosphatase activity
BF25_2589	COG4473	ABC transporter
BF25_259	COG2868	ribosomal protein
BF25_2590	COG1131	(ABC) transporter
BF25_2592	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BF25_2594	COG0456	acetyltransferase
BF25_2596	COG1794	racemase activity, acting on amino acids and derivatives
BF25_2597	COG1454	alcohol dehydrogenase
BF25_2598	COG2610	gluconate transmembrane transporter activity
BF25_26	COG0745	RESPONSE REGULATOR receiver
BF25_2603	COG0733	neurotransmitter:sodium symporter activity
BF25_2606	COG3850	Histidine kinase
BF25_2606	COG5002	protein histidine kinase activity
BF25_2607	COG0745	RESPONSE REGULATOR receiver
BF25_2608	COG0471	metal ion transport
BF25_2609	COG1929	Belongs to the glycerate kinase type-1 family
BF25_261	COG3290	protein histidine kinase activity
BF25_262	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BF25_2628	COG1674	ftsk spoiiie
BF25_263	COG0745	RESPONSE REGULATOR receiver
BF25_2632	COG0017	Asparaginyl-tRNA synthetase
BF25_2633	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BF25_2636	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BF25_2642	COG0018	arginyl-trna synthetase
BF25_2643	COG2521	methyltransferase
BF25_2643	COG2136	Putative SAM-dependent methyltransferase
BF25_2646	COG1413	lyase activity
BF25_2647	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BF25_265	COG5002	protein histidine kinase activity
BF25_2650	COG0629	single-stranded DNA binding
BF25_2653	COG0488	(ABC) transporter
BF25_2654	COG1418	mRNA catabolic process
BF25_2657	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF25_266	COG1136	(ABC) transporter
BF25_2660	COG2359	stage V sporulation protein S
BF25_2667	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BF25_2668	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BF25_2669	COG2146	nitrite reductase [NAD(P)H] activity
BF25_267	COG0577	efflux transmembrane transporter activity
BF25_2670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BF25_2670	COG1587	Uroporphyrinogen-III synthase
BF25_2672	COG1648	precorrin-2 dehydrogenase activity
BF25_2675	COG2223	nitrite transmembrane transporter activity
BF25_2677	COG0314	molybdopterin synthase activity
BF25_2678	COG0303	'Molybdopterin
BF25_2679	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF25_268	COG0577	efflux transmembrane transporter activity
BF25_2680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF25_2681	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF25_2685	COG2181	nitrate reductase activity
BF25_2686	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BF25_2687	COG1140	nitrate reductase beta subunit
BF25_2688	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BF25_269	COG0077	Prephenate dehydratase
BF25_2691	COG0714	Associated with various cellular activities
BF25_2692	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BF25_2693	COG1305	Transglutaminase-like
BF25_2694	COG0386	Belongs to the glutathione peroxidase family
BF25_2699	COG1595	DNA-templated transcription, initiation
BF25_270	COG2258	MOSC domain
BF25_2700	COG0604	alcohol dehydrogenase
BF25_2702	COG0346	lactoylglutathione lyase activity
BF25_2703	COG1082	Xylose isomerase domain protein TIM barrel
BF25_2707	COG2226	methyltransferase
BF25_271	COG1827	regulation of RNA biosynthetic process
BF25_2712	COG3874	Sporulation protein YtfJ
BF25_272	COG1104	cysteine desulfurase activity
BF25_2721	COG0456	acetyltransferase
BF25_2727	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_2728	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_2729	COG1819	glycosyl
BF25_273	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BF25_2733	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF25_2735	COG0561	phosphatase activity
BF25_2739	COG2211	Major facilitator Superfamily
BF25_274	COG0157	Belongs to the NadC ModD family
BF25_2740	COG0154	amidase activity
BF25_2742	COG1876	peptidase activity
BF25_2744	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF25_2748	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_2749	COG1114	Component of the transport system for branched-chain amino acids
BF25_2752	COG1253	flavin adenine dinucleotide binding
BF25_2753	COG2839	Protein conserved in bacteria
BF25_2754	COG0702	epimerase
BF25_2757	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF25_2759	COG1607	acyl-coa hydrolase
BF25_2760	COG3689	TIGRFAM TIGR03943 family protein
BF25_2761	COG0701	Predicted permease
BF25_2763	COG2244	polysaccharide biosynthetic process
BF25_2764	COG0586	Pfam SNARE associated Golgi protein
BF25_2765	COG1051	belongs to the nudix hydrolase family
BF25_2766	COG5337	Spore coat protein CotH
BF25_2768	COG0406	alpha-ribazole phosphatase activity
BF25_2771	COG4166	transmembrane transport
BF25_2773	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BF25_2775	COG0702	epimerase
BF25_2777	COG3443	Belongs to the bacterial solute-binding protein 9 family
BF25_2777	COG0803	Belongs to the bacterial solute-binding protein 9 family
BF25_2788	COG0456	acetyltransferase
BF25_2789	COG0523	cobalamin synthesis protein
BF25_279	COG0640	Transcriptional regulator
BF25_2790	COG4989	oxidoreductase activity
BF25_2792	COG1231	oxidoreductase activity
BF25_2794	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BF25_2797	COG0783	Belongs to the Dps family
BF25_2798	COG3949	Membrane
BF25_28	COG0123	including yeast histone deacetylase and acetoin utilization protein
BF25_280	COG0697	spore germination
BF25_2801	COG0840	transmembrane signaling receptor activity
BF25_2806	COG2814	Major facilitator Superfamily
BF25_2807	COG0667	Aldo Keto reductase
BF25_2808	COG0640	Transcriptional regulator
BF25_2809	COG1404	Belongs to the peptidase S8 family
BF25_281	COG0697	spore germination
BF25_2810	COG2002	toxin-antitoxin pair type II binding
BF25_2811	COG0577	efflux transmembrane transporter activity
BF25_2812	COG0577	efflux transmembrane transporter activity
BF25_2819	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF25_2821	COG1279	arginine transmembrane transporter activity
BF25_2822	COG2814	Major facilitator Superfamily
BF25_2823	COG2814	Major facilitator Superfamily
BF25_2824	COG2814	Major facilitator Superfamily
BF25_2826	COG1082	Xylose isomerase domain protein TIM barrel
BF25_2829	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_283	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BF25_2830	COG4264	IucA IucC family
BF25_2832	COG1247	-acetyltransferase
BF25_2833	COG1285	pathogenesis
BF25_2835	COG0726	polysaccharide deacetylase
BF25_2836	COG5002	protein histidine kinase activity
BF25_2837	COG0745	RESPONSE REGULATOR receiver
BF25_2839	COG1316	TRANSCRIPTIONal
BF25_2844	COG0460	homoserine dehydrogenase
BF25_2848	COG0726	polysaccharide deacetylase
BF25_2850	COG0300	oxidoreductase activity
BF25_2852	COG5002	protein histidine kinase activity
BF25_2853	COG0745	RESPONSE REGULATOR receiver
BF25_2854	COG1132	(ABC) transporter
BF25_2855	COG1132	(ABC) transporter
BF25_2857	COG1388	LysM domain
BF25_2857	COG0791	NLP P60 protein
BF25_2859	COG1686	Belongs to the peptidase S11 family
BF25_2863	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BF25_2864	COG4988	ABC transporter
BF25_2865	COG1294	oxidase, subunit
BF25_2866	COG1271	oxidase subunit
BF25_2868	COG1846	Transcriptional regulator
BF25_2870	COG1942	4-Oxalocrotonate Tautomerase
BF25_2872	COG0583	DNA-binding transcription factor activity
BF25_2876	COG0411	ABC transporter
BF25_2878	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_2879	COG2030	dehydratase
BF25_2880	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_2883	COG0523	cobalamin synthesis protein
BF25_2884	COG1231	oxidoreductase activity
BF25_2885	COG0039	L-malate dehydrogenase activity
BF25_2886	COG0628	permease
BF25_2889	COG0778	Nitroreductase
BF25_289	COG1862	Preprotein translocase
BF25_2890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BF25_2891	COG1959	2 iron, 2 sulfur cluster binding
BF25_2892	COG0583	DNA-binding transcription factor activity
BF25_2893	COG0697	spore germination
BF25_2895	COG4549	nuclear export factor GLE1
BF25_2896	COG2372	response to copper ion
BF25_2896	COG1276	copper resistance
BF25_2898	COG1114	Component of the transport system for branched-chain amino acids
BF25_2899	COG1114	Component of the transport system for branched-chain amino acids
BF25_29	COG0517	IMP dehydrogenase activity
BF25_2900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BF25_2906	COG2132	Multicopper oxidase
BF25_2907	COG0006	proline dipeptidase activity
BF25_291	COG2323	membrane
BF25_2911	COG4224	UPF0291 protein
BF25_2913	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BF25_2914	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_2916	COG2390	Transcriptional regulator
BF25_292	COG2244	polysaccharide biosynthetic process
BF25_2921	COG0531	amino acid
BF25_2922	COG0531	amino acid
BF25_2924	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF25_2927	COG1914	H( )-stimulated, divalent metal cation uptake system
BF25_2932	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_2938	COG4166	transmembrane transport
BF25_2939	COG1073	alpha beta
BF25_294	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF25_294	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BF25_2943	COG0427	acetyl-CoA hydrolase
BF25_2944	COG3279	Response regulator of the LytR AlgR family
BF25_2946	COG3384	dioxygenase
BF25_2947	COG2814	Major facilitator Superfamily
BF25_295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BF25_2952	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BF25_2954	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BF25_2955	COG0440	acetolactate synthase activity
BF25_2956	COG0028	Belongs to the TPP enzyme family
BF25_2957	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF25_2959	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF25_296	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BF25_296	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BF25_2963	COG2084	Dehydrogenase
BF25_2966	COG2323	membrane
BF25_2967	COG5566	PFAM Mor transcription activator
BF25_2969	COG0733	neurotransmitter:sodium symporter activity
BF25_2970	COG2244	polysaccharide biosynthetic process
BF25_2973	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF25_2974	COG2223	nitrite transmembrane transporter activity
BF25_2975	COG4166	transmembrane transport
BF25_2977	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BF25_2979	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_298	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BF25_2980	COG0477	Major facilitator Superfamily
BF25_2981	COG0477	Major facilitator Superfamily
BF25_2983	COG1966	Carbon starvation protein
BF25_2988	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF25_2989	COG1051	belongs to the nudix hydrolase family
BF25_3	COG4848	Belongs to the UPF0354 family
BF25_30	COG0454	-acetyltransferase
BF25_3000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF25_3001	COG0784	Response regulator, receiver
BF25_3002	COG4191	Histidine kinase
BF25_3003	COG0281	malic enzyme
BF25_3004	COG1027	Aspartate ammonia-lyase
BF25_3006	COG0528	UMP kinase activity
BF25_3007	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF25_301	COG0124	histidyl-tRNA synthetase
BF25_3010	COG1131	(ABC) transporter
BF25_3017	COG2733	membrane
BF25_3024	COG0785	Cytochrome C biogenesis protein
BF25_3028	COG3340	Belongs to the peptidase S51 family
BF25_3029	COG0534	Mate efflux family protein
BF25_303	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BF25_3030	COG0534	Mate efflux family protein
BF25_3034	COG0114	fumarate hydratase activity
BF25_3035	COG1757	Na H antiporter
BF25_3036	COG0438	transferase activity, transferring glycosyl groups
BF25_3036	COG1216	Glycosyl transferase, family 2
BF25_3038	COG0701	Predicted permease
BF25_3039	COG0523	cobalamin synthesis protein
BF25_3040	COG0697	spore germination
BF25_3041	COG1802	Transcriptional regulator
BF25_3047	COG0367	asparagine synthase
BF25_305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BF25_3054	COG0406	alpha-ribazole phosphatase activity
BF25_3056	COG1686	Belongs to the peptidase S11 family
BF25_306	COG1959	2 iron, 2 sulfur cluster binding
BF25_3061	COG1234	tRNA 3'-trailer cleavage
BF25_3062	COG1177	transmembrane transport
BF25_3063	COG0725	ABC transporter, periplasmic molybdate-binding protein
BF25_3064	COG3842	ATPase activity
BF25_307	COG1104	cysteine desulfurase activity
BF25_3070	COG2329	Antibiotic biosynthesis monooxygenase
BF25_3074	COG1309	transcriptional regulator
BF25_3079	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF25_308	COG0482	sulfurtransferase activity
BF25_3080	COG4786	Flagellar basal body rod
BF25_3083	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BF25_3084	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BF25_3086	COG1987	bacterial-type flagellum assembly
BF25_3087	COG1338	Plays a role in the flagellum-specific transport system
BF25_3089	COG1776	CheC inhibitor of MCP methylation
BF25_3089	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF25_3091	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF25_3092	COG0741	lytic transglycosylase activity
BF25_3093	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BF25_3098	COG0463	Glycosyl transferase, family 2
BF25_3098	COG0457	Tetratricopeptide repeat
BF25_31	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF25_310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BF25_3104	COG0463	Glycosyl transferase, family 2
BF25_3106	COG0784	Response regulator, receiver
BF25_3106	COG0835	chemotaxis
BF25_3107	COG0835	chemotaxis
BF25_3107	COG0784	Response regulator, receiver
BF25_3116	COG1157	protein secretion by the type III secretion system
BF25_3118	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF25_3120	COG1766	The M ring may be actively involved in energy transduction
BF25_3121	COG1677	Flagellar hook-basal body complex protein FliE
BF25_3122	COG1558	bacterial-type flagellum-dependent cell motility
BF25_3123	COG1815	bacterial-type flagellum-dependent cell motility
BF25_3128	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BF25_3129	COG1256	bacterial-type flagellum assembly
BF25_3133	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BF25_3136	COG1776	CheC inhibitor of MCP methylation
BF25_3136	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BF25_3137	COG2198	Histidine kinase
BF25_3137	COG0643	Histidine kinase
BF25_3138	COG0643	Histidine kinase
BF25_3138	COG2198	Histidine kinase
BF25_3139	COG2201	protein-glutamate methylesterase activity
BF25_314	COG0628	permease
BF25_3140	COG1360	Flagellar Motor Protein
BF25_3141	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BF25_3143	COG1923	regulation of RNA biosynthetic process
BF25_3154	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BF25_3155	COG2323	membrane
BF25_3157	COG4978	Transcriptional regulator
BF25_3157	COG0789	Transcriptional regulator
BF25_3158	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF25_3159	COG0475	glutathione-regulated potassium exporter activity
BF25_316	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BF25_3161	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF25_3162	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF25_3163	COG3162	membrane
BF25_3166	COG1280	lysine exporter protein (LysE YggA)
BF25_3174	COG0328	RNA-DNA hybrid ribonuclease activity
BF25_3178	COG0454	-acetyltransferase
BF25_3183	COG1215	transferase activity, transferring glycosyl groups
BF25_3186	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BF25_3192	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BF25_3195	COG0754	glutathionylspermidine amidase activity
BF25_320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BF25_3200	COG0456	acetyltransferase
BF25_3202	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF25_3204	COG2311	Membrane
BF25_3205	COG2233	PERMEase
BF25_3207	COG0024	Methionine aminopeptidase
BF25_3208	COG3173	Aminoglycoside phosphotransferase
BF25_3210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BF25_3211	COG1199	ATP-dependent helicase activity
BF25_3213	COG0116	Belongs to the methyltransferase superfamily
BF25_3215	COG4474	Belongs to the UPF0398 family
BF25_3224	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF25_3224	COG4499	WXG100 protein secretion system (Wss), protein YukC
BF25_3226	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BF25_3227	COG3935	DnaD domain protein
BF25_3231	COG1199	ATP-dependent helicase activity
BF25_3231	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BF25_3238	COG0438	transferase activity, transferring glycosyl groups
BF25_3239	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BF25_3242	COG1694	Mazg nucleotide pyrophosphohydrolase
BF25_3243	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_3245	COG2738	Putative neutral zinc metallopeptidase
BF25_3248	COG4347	Protein of unknown function (DUF1405)
BF25_3250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BF25_3254	COG0457	Tetratricopeptide repeat
BF25_3255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BF25_3258	COG0105	UTP biosynthetic process
BF25_3259	COG0142	geranyltranstransferase activity
BF25_326	COG0768	penicillin binding
BF25_3261	COG0142	geranyltranstransferase activity
BF25_3264	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BF25_3278	COG0252	asparaginase activity
BF25_3279	COG0492	ferredoxin-NADP+ reductase activity
BF25_3283	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF25_3284	COG4862	establishment of competence for transformation
BF25_3286	COG1408	metallophosphoesterase
BF25_3288	COG1266	CAAX protease self-immunity
BF25_3289	COG0514	ATP-dependent DNA helicase (RecQ)
BF25_3290	COG4955	Helix-turn-helix domain
BF25_3291	COG1141	Ferredoxin
BF25_3292	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BF25_3295	COG2096	Adenosyltransferase
BF25_3296	COG5002	protein histidine kinase activity
BF25_3297	COG0745	RESPONSE REGULATOR receiver
BF25_3298	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BF25_3299	COG1333	cytochrome c biogenesis protein
BF25_33	COG1595	DNA-templated transcription, initiation
BF25_3301	COG1187	pseudouridine synthase activity
BF25_3302	COG0700	Nucleoside recognition
BF25_3303	COG2715	membrane protein required for spore maturation
BF25_3304	COG1686	Belongs to the peptidase S11 family
BF25_3305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF25_3308	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BF25_3308	COG0392	lysyltransferase activity
BF25_331	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF25_3312	COG5002	protein histidine kinase activity
BF25_3313	COG0582	viral genome integration into host DNA
BF25_3315	COG1801	Protein of unknown function DUF72
BF25_3316	COG3852	Histidine kinase
BF25_3319	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF25_332	COG0626	cystathionine gamma-synthase activity
BF25_3320	COG1392	Phosphate transport regulator
BF25_3321	COG0306	phosphate transporter
BF25_3322	COG0730	response to heat
BF25_3325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BF25_3325	COG1017	nitric oxide dioxygenase activity
BF25_333	COG1454	alcohol dehydrogenase
BF25_333	COG1012	belongs to the aldehyde dehydrogenase family
BF25_3330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BF25_3332	COG1114	Component of the transport system for branched-chain amino acids
BF25_3334	COG2197	response regulator
BF25_3335	COG4585	Histidine kinase
BF25_3336	COG4758	membrane
BF25_3339	COG1757	Na H antiporter
BF25_3343	COG0733	neurotransmitter:sodium symporter activity
BF25_3344	COG1648	precorrin-2 dehydrogenase activity
BF25_3348	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BF25_3349	COG0529	Catalyzes the synthesis of activated sulfate
BF25_335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_3353	COG0019	diaminopimelate decarboxylase activity
BF25_3355	COG1368	sulfuric ester hydrolase activity
BF25_3356	COG1183	phosphatidylcholine synthase activity
BF25_3359	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BF25_3366	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BF25_3371	COG0473	3-isopropylmalate dehydrogenase activity
BF25_3373	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BF25_3374	COG0440	acetolactate synthase activity
BF25_3375	COG0028	Belongs to the TPP enzyme family
BF25_3376	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF25_3381	COG3874	Sporulation protein YtfJ
BF25_3382	COG4709	membrane
BF25_3383	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF25_3384	COG1301	dicarboxylic acid transport
BF25_3386	COG1846	Transcriptional regulator
BF25_3389	COG1968	undecaprenyl-diphosphatase activity
BF25_3390	COG0534	Mate efflux family protein
BF25_3394	COG3173	Aminoglycoside phosphotransferase
BF25_3397	COG0716	FMN binding
BF25_3402	COG1696	Membrane protein involved in D-alanine export
BF25_3404	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BF25_3405	COG2070	2-Nitropropane dioxygenase
BF25_3406	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF25_3408	COG1335	isochorismatase
BF25_3410	COG1522	sequence-specific DNA binding
BF25_3413	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BF25_3414	COG1131	(ABC) transporter
BF25_3416	COG1131	(ABC) transporter
BF25_3417	COG1725	Transcriptional regulator
BF25_3418	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF25_3419	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF25_3421	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BF25_3422	COG1780	Probably involved in ribonucleotide reductase function
BF25_3428	COG4873	Protein conserved in bacteria
BF25_343	COG2259	Doxx family
BF25_3431	COG0720	synthase
BF25_3433	COG5002	protein histidine kinase activity
BF25_3435	COG2318	DinB family
BF25_3437	COG1846	Transcriptional regulator
BF25_3438	COG3852	Histidine kinase
BF25_344	COG2514	catechol 2,3-dioxygenase activity
BF25_3440	COG2861	carbohydrate metabolic process
BF25_3443	COG0235	Class ii aldolase
BF25_3448	COG1349	DNA-binding transcription factor activity
BF25_345	COG2514	catechol 2,3-dioxygenase activity
BF25_3451	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF25_3454	COG3842	ATPase activity
BF25_3455	COG3842	ATPase activity
BF25_3457	COG1840	ABC-type Fe3 transport system, periplasmic component
BF25_3460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF25_3462	COG3243	poly(R)-hydroxyalkanoic acid synthase
BF25_3463	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_3467	COG2030	dehydratase
BF25_3469	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BF25_347	COG3186	Phenylalanine-4-hydroxylase
BF25_3470	COG0861	Integral membrane protein TerC family
BF25_3471	COG2116	formate transmembrane transporter activity
BF25_3473	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BF25_3477	COG2186	Transcriptional regulator
BF25_3478	COG5002	protein histidine kinase activity
BF25_3479	COG0745	RESPONSE REGULATOR receiver
BF25_348	COG1404	Belongs to the peptidase S8 family
BF25_3481	COG3835	regulator
BF25_3482	COG0277	FAD linked oxidase domain protein
BF25_3483	COG0247	lactate metabolic process
BF25_3484	COG2340	Cysteine-rich secretory protein family
BF25_3486	COG0564	pseudouridine synthase activity
BF25_3488	COG2409	Drug exporters of the RND superfamily
BF25_3490	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BF25_3491	COG1177	transmembrane transport
BF25_3492	COG1176	ABC-type spermidine putrescine transport system, permease component I
BF25_3493	COG3842	ATPase activity
BF25_3494	COG1012	belongs to the aldehyde dehydrogenase family
BF25_35	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BF25_3500	COG0681	Belongs to the peptidase S26 family
BF25_3501	COG1686	Belongs to the peptidase S11 family
BF25_3503	COG2226	methyltransferase
BF25_3514	COG1476	TRANSCRIPTIONal
BF25_3516	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF25_3526	COG5634	Uncharacterized conserved protein (DUF2278)
BF25_3527	COG1620	l-lactate permease
BF25_3534	COG0512	Glutamine amidotransferase of anthranilate synthase
BF25_3534	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BF25_3536	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF25_3537	COG5492	domain, Protein
BF25_3540	COG2382	esterase
BF25_3541	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BF25_3542	COG2153	protein acetylation
BF25_355	COG2267	carboxylic ester hydrolase activity
BF25_3550	COG1091	dTDP-4-dehydrorhamnose reductase activity
BF25_3553	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BF25_3557	COG0457	Tetratricopeptide repeat
BF25_3557	COG0463	Glycosyl transferase, family 2
BF25_3561	COG1216	Glycosyl transferase, family 2
BF25_3562	COG0772	Belongs to the SEDS family
BF25_3563	COG0772	Belongs to the SEDS family
BF25_3567	COG0564	pseudouridine synthase activity
BF25_3568	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BF25_3569	COG2357	RelA SpoT domain protein
BF25_357	COG1785	Belongs to the alkaline phosphatase family
BF25_3571	COG4116	CYTH
BF25_3572	COG2346	COG2346, Truncated hemoglobins
BF25_3575	COG1164	Oligoendopeptidase f
BF25_3577	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF25_3578	COG4862	establishment of competence for transformation
BF25_3579	COG0861	Integral membrane protein TerC family
BF25_3580	COG1393	Belongs to the ArsC family
BF25_3582	COG4166	transmembrane transport
BF25_3583	COG0534	Mate efflux family protein
BF25_3584	COG4608	Belongs to the ABC transporter superfamily
BF25_3585	COG0444	Belongs to the ABC transporter superfamily
BF25_3586	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BF25_3587	COG0601	transmembrane transport
BF25_3588	COG4166	transmembrane transport
BF25_359	COG2357	RelA SpoT domain protein
BF25_3590	COG0180	Tryptophanyl-tRNA synthetase
BF25_3592	COG5504	Zn-dependent protease
BF25_3593	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BF25_3594	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_3597	COG2267	carboxylic ester hydrolase activity
BF25_3599	COG0542	response to heat
BF25_360	COG0778	Nitroreductase
BF25_3601	COG0561	phosphatase activity
BF25_3604	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_3606	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF25_3608	COG2996	Protein conserved in bacteria
BF25_3614	COG0753	catalase activity
BF25_3616	COG0367	asparagine synthase
BF25_362	COG1595	DNA-templated transcription, initiation
BF25_3621	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF25_3629	COG1074	ATP-dependent DNA helicase activity
BF25_3630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BF25_3632	COG0398	Pfam SNARE associated Golgi protein
BF25_3633	COG4903	ComK protein
BF25_3636	COG1278	Cold shock
BF25_3638	COG2224	Isocitrate lyase
BF25_3639	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BF25_3640	COG0497	DNA recombination
BF25_3643	COG0697	spore germination
BF25_3644	COG0840	transmembrane signaling receptor activity
BF25_3645	COG0501	Belongs to the peptidase M48B family
BF25_365	COG1191	sigma factor activity
BF25_3650	COG0745	RESPONSE REGULATOR receiver
BF25_3651	COG2205	protein histidine kinase activity
BF25_3654	COG3708	Transcriptional regulator
BF25_3654	COG2207	Transcriptional regulator
BF25_3655	COG1595	DNA-templated transcription, initiation
BF25_3657	COG1078	dGTPase activity
BF25_3658	COG1408	metallophosphoesterase
BF25_3665	COG3209	COG3209 Rhs family protein
BF25_3671	COG0318	PFAM AMP-dependent synthetase and ligase
BF25_3673	COG0095	Lipoate-protein ligase
BF25_3674	COG1234	tRNA 3'-trailer cleavage
BF25_3676	COG1609	Transcriptional regulator
BF25_368	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BF25_3681	COG1511	domain protein
BF25_3682	COG1309	transcriptional regulator
BF25_369	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BF25_3691	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BF25_3692	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF25_3693	COG2329	Antibiotic biosynthesis monooxygenase
BF25_3694	COG3428	Bacterial PH domain
BF25_3695	COG3402	PFAM membrane-flanked domain
BF25_3704	COG3428	Bacterial PH domain
BF25_3706	COG3402	PFAM membrane-flanked domain
BF25_3708	COG1309	transcriptional regulator
BF25_371	COG1534	Rna-binding protein
BF25_3711	COG4473	ABC transporter
BF25_3712	COG1131	(ABC) transporter
BF25_3713	COG0537	adenosine 5'-monophosphoramidase activity
BF25_3714	COG4980	gas vesicle protein
BF25_3718	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BF25_3719	COG3973	AAA domain
BF25_3721	COG0477	Major facilitator Superfamily
BF25_3722	COG0477	Major facilitator Superfamily
BF25_373	COG1713	HD superfamily hydrolase involved in NAD metabolism
BF25_3730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BF25_3732	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BF25_3733	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BF25_3737	COG2267	carboxylic ester hydrolase activity
BF25_3739	COG0457	Tetratricopeptide repeat
BF25_374	COG0799	negative regulation of ribosome biogenesis
BF25_3740	COG0346	lactoylglutathione lyase activity
BF25_3741	COG0346	lactoylglutathione lyase activity
BF25_3742	COG2814	Major facilitator Superfamily
BF25_3743	COG1309	transcriptional regulator
BF25_3747	COG4717	serine-type aminopeptidase activity
BF25_3748	COG0420	3'-5' exonuclease activity
BF25_375	COG2226	methyltransferase
BF25_3754	COG0393	Putative heavy-metal-binding
BF25_3759	COG0784	Response regulator, receiver
BF25_3759	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF25_3759	COG2205	protein histidine kinase activity
BF25_3759	COG2198	Histidine kinase
BF25_376	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF25_3760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BF25_3761	COG2208	phosphoserine phosphatase activity
BF25_3763	COG1191	sigma factor activity
BF25_3768	COG3237	CsbD-like
BF25_377	COG1596	polysaccharide export
BF25_377	COG1555	photosystem II stabilization
BF25_3778	COG2770	Histidine kinase
BF25_3778	COG3437	response regulator, receiver
BF25_378	COG2131	deaminase
BF25_3783	COG1959	2 iron, 2 sulfur cluster binding
BF25_3784	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BF25_3785	COG2376	Dihydroxyacetone kinase
BF25_3787	COG2376	Dihydroxyacetone kinase
BF25_379	COG0658	competence protein
BF25_379	COG2333	competence protein COMEC
BF25_3791	COG1183	phosphatidylcholine synthase activity
BF25_3796	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BF25_3796	COG3320	Male sterility
BF25_3806	COG0477	Major facilitator Superfamily
BF25_381	COG1466	dna polymerase III delta subunit
BF25_3814	COG0305	Participates in initiation and elongation during chromosome replication
BF25_3817	COG0789	Transcriptional regulator
BF25_3817	COG4978	Transcriptional regulator
BF25_3822	COG3181	Tripartite tricarboxylate transporter family receptor
BF25_3823	COG4565	transcriptional regulatory protein
BF25_3824	COG3290	protein histidine kinase activity
BF25_3825	COG0477	Major facilitator Superfamily
BF25_3831	COG4608	Belongs to the ABC transporter superfamily
BF25_3832	COG0444	Belongs to the ABC transporter superfamily
BF25_3833	COG0444	Belongs to the ABC transporter superfamily
BF25_3834	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BF25_3835	COG0601	transmembrane transport
BF25_3842	COG3938	Belongs to the proline racemase family
BF25_3846	COG1363	Peptidase, m42
BF25_3849	COG1024	Enoyl-CoA hydratase
BF25_3852	COG1696	Membrane protein involved in D-alanine export
BF25_3855	COG4196	transglutaminase domain protein
BF25_3856	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF25_3858	COG2244	polysaccharide biosynthetic process
BF25_3859	COG0653	protein targeting
BF25_386	COG1733	regulation of RNA biosynthetic process
BF25_3863	COG0659	secondary active sulfate transmembrane transporter activity
BF25_3866	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF25_3868	COG3409	Peptidoglycan-binding domain 1 protein
BF25_3868	COG5632	N-Acetylmuramoyl-L-alanine amidase
BF25_387	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BF25_3870	COG0561	phosphatase activity
BF25_3873	COG3527	Alpha-acetolactate decarboxylase
BF25_3874	COG0028	Belongs to the TPP enzyme family
BF25_3880	COG0189	ligase activity
BF25_3883	COG1126	abc transporter atp-binding protein
BF25_3884	COG0765	amino acid transport
BF25_3885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF25_3886	COG1132	(ABC) transporter
BF25_3887	COG1132	(ABC) transporter
BF25_3888	COG1132	(ABC) transporter
BF25_3889	COG1012	belongs to the aldehyde dehydrogenase family
BF25_389	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BF25_3891	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BF25_3892	COG0531	amino acid
BF25_3894	COG0693	protein deglycase activity
BF25_3894	COG0753	catalase activity
BF25_3895	COG0693	protein deglycase activity
BF25_3897	COG2211	Major facilitator Superfamily
BF25_3898	COG4533	DNA binding
BF25_3899	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF25_39	COG0626	cystathionine gamma-synthase activity
BF25_3901	COG1733	regulation of RNA biosynthetic process
BF25_3902	COG2814	Major facilitator Superfamily
BF25_3903	COG1309	transcriptional regulator
BF25_3904	COG2076	Multidrug Resistance protein
BF25_3905	COG2076	Multidrug Resistance protein
BF25_3907	COG1522	sequence-specific DNA binding
BF25_3908	COG0697	spore germination
BF25_3911	COG2259	Doxx family
BF25_3913	COG1263	PTS System
BF25_3913	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_3915	COG1737	Transcriptional regulator
BF25_3917	COG0475	glutathione-regulated potassium exporter activity
BF25_3918	COG0531	amino acid
BF25_3924	COG0586	Pfam SNARE associated Golgi protein
BF25_393	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BF25_3931	COG3546	catalase activity
BF25_3932	COG1114	Component of the transport system for branched-chain amino acids
BF25_3935	COG5522	Integral membrane protein (intg_mem_TP0381)
BF25_3937	COG1136	(ABC) transporter
BF25_3938	COG0577	efflux transmembrane transporter activity
BF25_3939	COG1388	LysM domain
BF25_3939	COG3584	3D domain protein
BF25_394	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF25_3943	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF25_3944	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF25_3945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF25_3945	COG3711	transcriptional antiterminator
BF25_3948	COG1283	sodium-dependent phosphate transmembrane transporter activity
BF25_3949	COG0604	alcohol dehydrogenase
BF25_3950	COG1316	TRANSCRIPTIONal
BF25_3952	COG0730	response to heat
BF25_3953	COG2210	Belongs to the sulfur carrier protein TusA family
BF25_3955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_3957	COG0425	Belongs to the sulfur carrier protein TusA family
BF25_3958	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_3958	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_3959	COG0425	Belongs to the sulfur carrier protein TusA family
BF25_3959	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_396	COG1610	YqeY-like protein
BF25_3960	COG1937	Protein conserved in bacteria
BF25_3961	COG0446	pyridine nucleotide-disulphide oxidoreductase
BF25_3966	COG2719	SpoVR family
BF25_3967	COG0778	Nitroreductase
BF25_3975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BF25_3976	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF25_3978	COG1609	Transcriptional regulator
BF25_3979	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_3979	COG1263	PTS System
BF25_3980	COG1621	beta-fructofuranosidase activity
BF25_3981	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF25_3985	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_3986	COG2252	PERMEase
BF25_3989	COG1846	Transcriptional regulator
BF25_399	COG1702	phosphate starvation-inducible protein PhoH
BF25_3990	COG2814	Major facilitator Superfamily
BF25_3991	COG2205	protein histidine kinase activity
BF25_3998	COG0351	phosphomethylpyrimidine kinase
BF25_3999	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF25_4	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_40	COG1956	GAF domain-containing protein
BF25_400	COG1480	7TM receptor with intracellular HD hydrolase
BF25_4001	COG2104	thiamine diphosphate biosynthetic process
BF25_4002	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF25_4003	COG0352	thiamine-phosphate diphosphorylase activity
BF25_4004	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF25_4005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF25_4006	COG1116	anion transmembrane transporter activity
BF25_4007	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BF25_4011	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BF25_402	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BF25_403	COG0295	cytidine deaminase activity
BF25_4036	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF25_4038	COG0581	inorganic phosphate transmembrane transporter activity
BF25_4039	COG0573	inorganic phosphate transmembrane transporter activity
BF25_404	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BF25_4040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BF25_4041	COG1918	ferrous iron import across plasma membrane
BF25_4041	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF25_4042	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF25_4043	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BF25_4045	COG0531	amino acid
BF25_4046	COG0697	spore germination
BF25_4047	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BF25_4050	COG4990	cell redox homeostasis
BF25_4051	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BF25_4052	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BF25_4055	COG0475	glutathione-regulated potassium exporter activity
BF25_4055	COG0569	domain protein
BF25_4060	COG2252	PERMEase
BF25_4061	COG1113	amino acid transport
BF25_4064	COG1114	Component of the transport system for branched-chain amino acids
BF25_4065	COG3104	oligopeptide transport
BF25_4068	COG1476	TRANSCRIPTIONal
BF25_4069	COG1388	LysM domain
BF25_4069	COG3584	3D domain protein
BF25_407	COG0517	IMP dehydrogenase activity
BF25_4070	COG0840	transmembrane signaling receptor activity
BF25_4071	COG1968	undecaprenyl-diphosphatase activity
BF25_4076	COG3568	Endonuclease Exonuclease Phosphatase
BF25_4079	COG1063	alcohol dehydrogenase
BF25_4083	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BF25_4084	COG1879	ABC-type sugar transport system periplasmic component
BF25_4085	COG1172	Belongs to the binding-protein-dependent transport system permease family
BF25_4086	COG1129	ABC transporter
BF25_4088	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BF25_4089	COG1609	Transcriptional regulator
BF25_409	COG0358	DNA primase activity
BF25_4090	COG0477	Major facilitator Superfamily
BF25_4091	COG0477	Major facilitator Superfamily
BF25_4092	COG1846	Transcriptional regulator
BF25_4093	COG2271	Major facilitator Superfamily
BF25_4095	COG4608	Belongs to the ABC transporter superfamily
BF25_4096	COG0601	transmembrane transport
BF25_4098	COG0747	negative chemotaxis
BF25_41	COG1309	transcriptional regulator
BF25_410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BF25_4101	COG0659	secondary active sulfate transmembrane transporter activity
BF25_4105	COG5002	protein histidine kinase activity
BF25_4106	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BF25_4107	COG2378	regulation of single-species biofilm formation
BF25_411	COG2010	Cytochrome c
BF25_4112	COG0833	amino acid
BF25_4113	COG0765	amino acid transport
BF25_4114	COG0765	amino acid transport
BF25_4115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF25_4116	COG1126	abc transporter atp-binding protein
BF25_4117	COG1115	amino acid carrier protein
BF25_4118	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BF25_412	COG2384	SAM-dependent methyltransferase
BF25_4120	COG0697	spore germination
BF25_4123	COG0366	Alpha amylase catalytic
BF25_4124	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_4124	COG1263	PTS System
BF25_4125	COG2188	Transcriptional regulator
BF25_4126	COG0531	amino acid
BF25_413	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BF25_4130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF25_4131	COG0714	Associated with various cellular activities
BF25_4132	COG4548	von Willebrand factor, type A
BF25_4134	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF25_4135	COG0156	8-amino-7-oxononanoate synthase activity
BF25_4136	COG2226	methyltransferase
BF25_4138	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4139	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_4141	COG3104	oligopeptide transport
BF25_4144	COG1620	l-lactate permease
BF25_4145	COG1027	Aspartate ammonia-lyase
BF25_4146	COG1253	flavin adenine dinucleotide binding
BF25_4147	COG0346	lactoylglutathione lyase activity
BF25_4148	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_4149	COG1316	TRANSCRIPTIONal
BF25_4150	COG2720	vancomycin resistance protein
BF25_4154	COG3227	Zinc metalloprotease (Elastase)
BF25_4157	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BF25_4158	COG2217	Heavy metal translocating P-type atpase
BF25_4159	COG0640	Transcriptional regulator
BF25_4160	COG0531	amino acid
BF25_4165	COG3383	formate dehydrogenase (NAD+) activity
BF25_4166	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BF25_4167	COG0456	acetyltransferase
BF25_4167	COG0454	-acetyltransferase
BF25_4169	COG0745	RESPONSE REGULATOR receiver
BF25_4170	COG5002	protein histidine kinase activity
BF25_4172	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BF25_4175	COG0281	malic enzyme
BF25_4176	COG3493	citrate carrier protein
BF25_4177	COG4565	transcriptional regulatory protein
BF25_4178	COG3290	protein histidine kinase activity
BF25_4180	COG4990	cell redox homeostasis
BF25_4182	COG5002	protein histidine kinase activity
BF25_4183	COG0745	RESPONSE REGULATOR receiver
BF25_4184	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BF25_4186	COG0395	ABC-type sugar transport system, permease component
BF25_4187	COG1175	transmembrane transport
BF25_4188	COG3842	ATPase activity
BF25_4189	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BF25_419	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_4193	COG2851	Citrate transporter
BF25_4196	COG3290	protein histidine kinase activity
BF25_4198	COG2268	Band 7 protein
BF25_4199	COG1585	Membrane protein implicated in regulation of membrane protease activity
BF25_42	COG1309	transcriptional regulator
BF25_420	COG1121	(ABC) transporter
BF25_4201	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF25_4205	COG2766	serine protein kinase
BF25_4208	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BF25_421	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BF25_4210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BF25_4212	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BF25_4213	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BF25_422	COG0735	belongs to the Fur family
BF25_4238	COG0735	belongs to the Fur family
BF25_4239	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BF25_4243	COG4555	ABC transporter
BF25_4245	COG0069	glutamate synthase activity
BF25_4245	COG0067	glutamate synthase
BF25_4245	COG0070	glutamate synthase
BF25_4246	COG4129	membrane
BF25_4247	COG1132	(ABC) transporter
BF25_4251	COG1194	a g-specific adenine glycosylase
BF25_4252	COG1988	membrane-bound metal-dependent
BF25_4258	COG1090	epimerase
BF25_4259	COG1228	amidohydrolase
BF25_4263	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BF25_4266	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BF25_4266	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BF25_4269	COG0463	Glycosyl transferase, family 2
BF25_427	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF25_4272	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BF25_4273	COG1263	PTS System
BF25_4273	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_4274	COG2066	Belongs to the glutaminase family
BF25_4279	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF25_428	COG0477	Major facilitator Superfamily
BF25_4280	COG0833	amino acid
BF25_4282	COG3829	transcription factor binding
BF25_4284	COG0101	tRNA pseudouridine synthase activity
BF25_43	COG0697	spore germination
BF25_430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BF25_431	COG0573	inorganic phosphate transmembrane transporter activity
BF25_432	COG0581	inorganic phosphate transmembrane transporter activity
BF25_433	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BF25_4331	COG1484	DNA-dependent DNA replication
BF25_4338	COG1396	sequence-specific DNA binding
BF25_434	COG0704	Plays a role in the regulation of phosphate uptake
BF25_4342	COG0582	viral genome integration into host DNA
BF25_4343	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF25_4344	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BF25_4349	COG0535	radical SAM domain protein
BF25_435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BF25_4351	COG0387	Pfam Sodium calcium exchanger
BF25_4352	COG3871	stress protein (general stress protein 26)
BF25_4355	COG0586	Pfam SNARE associated Golgi protein
BF25_4358	COG0681	Belongs to the peptidase S26 family
BF25_4360	COG0697	spore germination
BF25_4361	COG2217	Heavy metal translocating P-type atpase
BF25_4362	COG1295	ribonuclease BN
BF25_4364	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BF25_4367	COG3853	Toxic anion resistance protein (TelA)
BF25_4369	COG0861	Integral membrane protein TerC family
BF25_437	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BF25_4370	COG2310	stress, protein
BF25_4371	COG2310	stress, protein
BF25_4372	COG2310	stress, protein
BF25_4375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BF25_4378	COG2270	Major facilitator Superfamily
BF25_438	COG4483	Protein conserved in bacteria
BF25_4387	COG0488	(ABC) transporter
BF25_4388	COG1116	anion transmembrane transporter activity
BF25_439	COG1940	carbohydrate kinase activity
BF25_4390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF25_4393	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BF25_4399	COG1263	PTS System
BF25_4399	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_4399	COG2190	(PTS) system
BF25_44	COG0583	DNA-binding transcription factor activity
BF25_4400	COG0366	Alpha amylase catalytic
BF25_4401	COG0840	transmembrane signaling receptor activity
BF25_4402	COG0840	transmembrane signaling receptor activity
BF25_4404	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF25_4405	COG0765	amino acid transport
BF25_4407	COG0723	plastoquinol--plastocyanin reductase activity
BF25_4407	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BF25_4408	COG2814	Major facilitator Superfamily
BF25_4409	COG3541	Predicted nucleotidyltransferase
BF25_441	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_4413	COG5002	protein histidine kinase activity
BF25_4419	COG0166	Belongs to the GPI family
BF25_4422	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_4423	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4424	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4425	COG0235	Class ii aldolase
BF25_4427	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BF25_4428	COG0450	alkyl hydroperoxide reductase
BF25_4431	COG1473	amidohydrolase
BF25_4437	COG4807	Protein conserved in bacteria
BF25_4439	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF25_4440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BF25_4441	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_4445	COG2309	aminopeptidase activity
BF25_4446	COG2076	Multidrug Resistance protein
BF25_4447	COG1012	belongs to the aldehyde dehydrogenase family
BF25_4449	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BF25_445	COG0626	cystathionine gamma-synthase activity
BF25_4450	COG0546	phosphoglycolate phosphatase activity
BF25_4451	COG1597	lipid kinase activity
BF25_4456	COG1846	Transcriptional regulator
BF25_4457	COG0003	Pfam Anion-transporting ATPase
BF25_4458	COG0003	Pfam Anion-transporting ATPase
BF25_446	COG0626	cystathionine gamma-synthase activity
BF25_4461	COG1464	Belongs to the NlpA lipoprotein family
BF25_4462	COG2011	ABC-type metal ion transport system permease component
BF25_4463	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BF25_4464	COG1335	isochorismatase
BF25_4468	COG4851	CamS sex pheromone cAM373 precursor
BF25_447	COG0646	methionine synthase
BF25_447	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BF25_4470	COG0210	DNA helicase
BF25_4475	COG0151	Belongs to the GarS family
BF25_4477	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BF25_4479	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BF25_448	COG1410	methionine synthase
BF25_448	COG0646	methionine synthase
BF25_4482	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BF25_4484	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BF25_4485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BF25_4486	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BF25_449	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BF25_4491	COG0745	RESPONSE REGULATOR receiver
BF25_4492	COG2205	protein histidine kinase activity
BF25_4495	COG1968	undecaprenyl-diphosphatase activity
BF25_4499	COG1215	transferase activity, transferring glycosyl groups
BF25_4505	COG2226	methyltransferase
BF25_4514	COG5002	protein histidine kinase activity
BF25_4516	COG2252	PERMEase
BF25_4520	COG1266	CAAX protease self-immunity
BF25_4523	COG0488	(ABC) transporter
BF25_4524	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BF25_4525	COG0456	acetyltransferase
BF25_4526	COG1214	PFAM Peptidase M22, glycoprotease
BF25_4527	COG0802	atpase or kinase
BF25_4545	COG2183	response to ionizing radiation
BF25_4546	COG2337	Toxic component of a toxin-antitoxin (TA) module
BF25_4547	COG0864	Transcriptional regulator
BF25_4548	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BF25_4549	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BF25_4551	COG4294	response to UV
BF25_4552	COG0705	Rhomboid family
BF25_4552	COG0457	Tetratricopeptide repeat
BF25_4554	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BF25_4557	COG2814	Major facilitator Superfamily
BF25_4559	COG0179	Fumarylacetoacetate (FAA) hydrolase
BF25_4560	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BF25_4563	COG0561	phosphatase activity
BF25_4564	COG4608	Belongs to the ABC transporter superfamily
BF25_4565	COG0561	phosphatase activity
BF25_4566	COG0444	Belongs to the ABC transporter superfamily
BF25_4568	COG0601	transmembrane transport
BF25_4569	COG0747	negative chemotaxis
BF25_4572	COG0488	(ABC) transporter
BF25_4576	COG5298	Protein conserved in bacteria
BF25_4577	COG0084	hydrolase, TatD family'
BF25_4580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_4582	COG1609	Transcriptional regulator
BF25_4584	COG0204	Acyl-transferase
BF25_4587	COG0697	spore germination
BF25_4588	COG0583	DNA-binding transcription factor activity
BF25_459	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BF25_4591	COG1910	domain protein
BF25_4592	COG0725	ABC transporter, periplasmic molybdate-binding protein
BF25_4593	COG0725	ABC transporter, periplasmic molybdate-binding protein
BF25_4594	COG4149	molybdate abc transporter
BF25_4595	COG4975	Glucose uptake
BF25_4597	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF25_4598	COG0656	L-ascorbic acid biosynthetic process
BF25_4599	COG4166	transmembrane transport
BF25_46	COG1104	cysteine desulfurase activity
BF25_460	COG1459	type II secretion system
BF25_4600	COG4166	transmembrane transport
BF25_4603	COG2207	Transcriptional regulator
BF25_4605	COG4166	transmembrane transport
BF25_4606	COG4608	Belongs to the ABC transporter superfamily
BF25_4607	COG0444	Belongs to the ABC transporter superfamily
BF25_4608	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BF25_4609	COG0601	transmembrane transport
BF25_4612	COG2814	Major facilitator Superfamily
BF25_4614	COG2271	Major facilitator Superfamily
BF25_4615	COG0277	FAD linked oxidase domain protein
BF25_4618	COG1464	Belongs to the NlpA lipoprotein family
BF25_4619	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BF25_462	COG4970	Tfp pilus assembly protein FimT
BF25_4620	COG2011	ABC-type metal ion transport system permease component
BF25_4621	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_4629	COG1506	peptidase
BF25_4629	COG4946	Tricorn protease homolog
BF25_4629	COG0823	Involved in the tonB-independent uptake of proteins
BF25_4630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BF25_4635	COG0596	Alpha beta hydrolase
BF25_4636	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BF25_4638	COG4856	YbbR-like protein
BF25_4639	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BF25_4657	COG0726	polysaccharide deacetylase
BF25_4658	COG2194	sulfuric ester hydrolase activity
BF25_4660	COG0489	protein tyrosine kinase activity
BF25_4661	COG0860	N-Acetylmuramoyl-L-alanine amidase
BF25_4665	COG0101	tRNA pseudouridine synthase activity
BF25_4666	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BF25_4667	COG1122	ATPase activity
BF25_4673	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BF25_4675	COG0024	Methionine aminopeptidase
BF25_4677	COG0201	protein transport
BF25_4682	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BF25_4703	COG1358	cellular component organization or biogenesis
BF25_4704	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BF25_4706	COG2813	Specifically methylates the guanine in position
BF25_4711	COG0250	Participates in transcription elongation, termination and antitermination
BF25_4712	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BF25_4714	COG3688	RNA-binding protein containing a PIN domain
BF25_4715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BF25_4718	COG1045	serine acetyltransferase
BF25_4722	COG4956	integral membrane protein (PIN domain superfamily)
BF25_4724	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BF25_4725	COG0542	response to heat
BF25_4727	COG3880	PFAM UvrB UvrC protein
BF25_473	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF25_4734	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BF25_4735	COG1396	sequence-specific DNA binding
BF25_4736	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BF25_4737	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BF25_4738	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BF25_4739	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BF25_4740	COG0512	Glutamine amidotransferase of anthranilate synthase
BF25_4741	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BF25_4742	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BF25_4745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BF25_4747	COG0037	tRNA processing
BF25_4748	COG2208	phosphoserine phosphatase activity
BF25_4751	COG1098	S1 RNA binding domain
BF25_4755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BF25_4756	COG3956	TIGRFAM MazG family protein
BF25_4757	COG2244	polysaccharide biosynthetic process
BF25_4758	COG2002	toxin-antitoxin pair type II binding
BF25_4759	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BF25_4761	COG0193	aminoacyl-tRNA hydrolase activity
BF25_4762	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BF25_4765	COG0251	oxidation-reduction process
BF25_4766	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BF25_4769	COG4466	Protein conserved in bacteria
BF25_4772	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BF25_4773	COG0084	hydrolase, TatD family'
BF25_4774	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_4774	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_4775	COG2002	toxin-antitoxin pair type II binding
BF25_4776	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BF25_4778	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BF25_4780	COG1774	PSP1 C-terminal conserved region
BF25_4781	COG0470	DNA polymerase III
BF25_4783	COG1982	Orn Lys Arg decarboxylase major
BF25_479	COG1725	Transcriptional regulator
BF25_4795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BF25_4796	COG0590	tRNA wobble adenosine to inosine editing
BF25_4797	COG1335	isochorismatase
BF25_4798	COG1428	Deoxynucleoside kinase
BF25_4799	COG1428	Deoxynucleoside kinase
BF25_480	COG1131	(ABC) transporter
BF25_4805	COG1686	Belongs to the peptidase S11 family
BF25_4806	COG0516	GMP reductase activity
BF25_4806	COG0517	IMP dehydrogenase activity
BF25_4814	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BF25_4815	COG0187	DNA topoisomerase II activity
BF25_4817	COG2501	S4 domain
BF25_4818	COG0592	DNA-directed DNA polymerase activity
BF25_4822	COG0706	membrane insertase activity
BF25_4823	COG1847	R3H domain protein
BF25_4824	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BF25_4828	COG1192	Involved in chromosome partitioning
BF25_4829	COG1475	DNA binding
BF25_4831	COG0668	transmembrane transport
BF25_4832	COG4481	Protein conserved in bacteria
BF25_4833	COG0012	GTP binding
BF25_4835	COG0629	single-stranded DNA binding
BF25_4837	COG4241	membrane
BF25_4838	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BF25_4840	COG0305	Participates in initiation and elongation during chromosome replication
BF25_4846	COG0745	RESPONSE REGULATOR receiver
BF25_4847	COG5002	protein histidine kinase activity
BF25_4848	COG4863	YycH protein
BF25_4849	COG4853	Protein conserved in bacteria
BF25_4850	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BF25_4851	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF25_4855	COG1164	Oligoendopeptidase f
BF25_4856	COG0516	GMP reductase activity
BF25_4860	COG1272	protein, Hemolysin III
BF25_4861	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF25_4865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BF25_4866	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BF25_4867	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF25_4868	COG2814	Major facilitator Superfamily
BF25_4869	COG3275	phosphorelay sensor kinase activity
BF25_4870	COG3279	Response regulator of the LytR AlgR family
BF25_4873	COG0628	permease
BF25_4874	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF25_4874	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BF25_4875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BF25_4876	COG1309	transcriptional regulator
BF25_4877	COG0463	Glycosyl transferase, family 2
BF25_488	COG2076	Multidrug Resistance protein
BF25_4882	COG0488	(ABC) transporter
BF25_4885	COG1607	acyl-coa hydrolase
BF25_4887	COG0840	transmembrane signaling receptor activity
BF25_489	COG2076	Multidrug Resistance protein
BF25_4892	COG0477	Major facilitator Superfamily
BF25_4893	COG3279	Response regulator of the LytR AlgR family
BF25_4894	COG1966	Carbon starvation protein
BF25_4895	COG2879	small protein
BF25_4896	COG3706	GGDEF domain
BF25_4897	COG0351	phosphomethylpyrimidine kinase
BF25_4898	COG4585	Histidine kinase
BF25_4898	COG2203	Gaf domain
BF25_4899	COG4585	Histidine kinase
BF25_4899	COG2203	Gaf domain
BF25_49	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BF25_4900	COG2197	response regulator
BF25_4902	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BF25_4903	COG1011	Hydrolase
BF25_4907	COG0460	homoserine dehydrogenase
BF25_4909	COG1609	Transcriptional regulator
BF25_491	COG1609	Transcriptional regulator
BF25_4910	COG2755	lipolytic protein G-D-S-L family
BF25_4911	COG1131	(ABC) transporter
BF25_4912	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BF25_4914	COG2814	Major facilitator Superfamily
BF25_4915	COG0561	phosphatase activity
BF25_4916	COG2233	PERMEase
BF25_492	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_4920	COG2363	Small membrane protein
BF25_4922	COG3773	Cell wall hydrolase
BF25_4925	COG0280	phosphate acetyltransferase
BF25_4926	COG0095	Lipoate-protein ligase
BF25_493	COG0095	Lipoate-protein ligase
BF25_4930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4931	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4932	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BF25_4933	COG1120	ATPase activity
BF25_4934	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BF25_4935	COG1078	dGTPase activity
BF25_4937	COG1994	Peptidase M50
BF25_4939	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BF25_4940	COG0584	glycerophosphoryl diester phosphodiesterase
BF25_4941	COG0789	Transcriptional regulator
BF25_4942	COG2814	Major facilitator Superfamily
BF25_4943	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BF25_4944	COG0010	Belongs to the arginase family
BF25_4947	COG1619	proteins homologs of microcin C7 resistance protein MccF
BF25_4948	COG4506	Protein conserved in bacteria
BF25_4949	COG0018	arginyl-trna synthetase
BF25_4950	COG1595	DNA-templated transcription, initiation
BF25_4954	COG2234	aminopeptidase activity
BF25_4958	COG0024	Methionine aminopeptidase
BF25_4959	COG1131	(ABC) transporter
BF25_4960	COG0842	Transport permease protein
BF25_4961	COG4585	Histidine kinase
BF25_4962	COG2197	response regulator
BF25_4966	COG5001	Diguanylate cyclase
BF25_4966	COG3300	MHYT domain
BF25_4968	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BF25_4969	COG2181	nitrate reductase activity
BF25_4969	COG0247	lactate metabolic process
BF25_4970	COG0183	Belongs to the thiolase family
BF25_4971	COG1250	3-hydroxyacyl-CoA dehydrogenase
BF25_4972	COG1960	acyl-CoA dehydrogenase activity
BF25_4973	COG1960	acyl-CoA dehydrogenase activity
BF25_4975	COG3343	RNA polymerase activity
BF25_4977	COG4821	SIS domain
BF25_498	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BF25_4980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF25_4981	COG1494	fructose-1,6-bisphosphatase
BF25_4982	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BF25_4985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BF25_4986	COG2890	protein-(glutamine-N5) methyltransferase activity
BF25_4989	COG0009	L-threonylcarbamoyladenylate synthase
BF25_499	COG3872	metal-dependent enzyme
BF25_4992	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BF25_4993	COG2259	Doxx family
BF25_4994	COG2190	(PTS) system
BF25_4996	COG0698	ribose 5-phosphate isomerase
BF25_5002	COG0356	it plays a direct role in the translocation of protons across the membrane
BF25_5012	COG3300	MHYT domain
BF25_5012	COG5001	Diguanylate cyclase
BF25_5013	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF25_5015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF25_5016	COG0649	NAD binding
BF25_5019	COG0839	Belongs to the complex I subunit 6 family
BF25_502	COG0006	proline dipeptidase activity
BF25_5021	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BF25_5022	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BF25_5023	COG1007	ATP synthesis coupled electron transport
BF25_5024	COG4836	Membrane
BF25_5026	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BF25_5027	COG2385	sporulation resulting in formation of a cellular spore
BF25_5028	COG4555	ABC transporter
BF25_5029	COG3279	Response regulator of the LytR AlgR family
BF25_5032	COG0739	heme binding
BF25_5034	COG1609	Transcriptional regulator
BF25_5042	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BF25_5043	COG1682	transport, permease protein
BF25_5044	COG1134	teichoic acid transport
BF25_5045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF25_5048	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BF25_5049	COG0745	RESPONSE REGULATOR receiver
BF25_5050	COG5002	protein histidine kinase activity
BF25_5057	COG1136	(ABC) transporter
BF25_5058	COG0577	efflux transmembrane transporter activity
BF25_5060	COG1191	sigma factor activity
BF25_5066	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BF25_5067	COG4715	Zinc finger, swim domain protein
BF25_507	COG3854	ATPases associated with a variety of cellular activities
BF25_5072	COG1388	LysM domain
BF25_5072	COG3584	3D domain protein
BF25_5073	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BF25_5078	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_5079	COG0791	NLP P60 protein
BF25_5079	COG1388	LysM domain
BF25_5082	COG1368	sulfuric ester hydrolase activity
BF25_5085	COG2389	metal-binding protein
BF25_5087	COG1620	l-lactate permease
BF25_5089	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF25_5090	COG1294	oxidase, subunit
BF25_5091	COG1271	oxidase subunit
BF25_5095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BF25_5096	COG0583	DNA-binding transcription factor activity
BF25_5097	COG1511	domain protein
BF25_5098	COG0346	lactoylglutathione lyase activity
BF25_51	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BF25_5100	COG1301	dicarboxylic acid transport
BF25_5101	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF25_5103	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF25_5104	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BF25_5105	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BF25_5107	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BF25_5108	COG1447	Phosphotransferase system cellobiose-specific component IIA
BF25_5109	COG1486	melibiose metabolic process
BF25_5110	COG3394	polysaccharide catabolic process
BF25_5113	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BF25_5113	COG3933	PFAM sigma-54 factor interaction domain-containing protein
BF25_5115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BF25_5116	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BF25_5117	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BF25_5118	COG1316	TRANSCRIPTIONal
BF25_5119	COG1739	Uncharacterized protein family UPF0029
BF25_5120	COG1307	EDD domain protein, DegV family
BF25_5121	COG1733	regulation of RNA biosynthetic process
BF25_5122	COG0791	NLP P60 protein
BF25_5122	COG1388	LysM domain
BF25_5123	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BF25_5124	COG1040	competence protein
BF25_5125	COG1278	Cold shock
BF25_5126	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BF25_5127	COG0653	protein targeting
BF25_5128	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BF25_5130	COG2884	Cell division ATP-binding protein ftsE
BF25_5131	COG2177	Part of the ABC transporter FtsEX involved in
BF25_5132	COG3409	Peptidoglycan-binding domain 1 protein
BF25_5132	COG0793	Belongs to the peptidase S41A family
BF25_5133	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BF25_5134	COG1132	(ABC) transporter
BF25_5137	COG0655	NAD(P)H dehydrogenase (quinone) activity
BF25_5139	COG0583	DNA-binding transcription factor activity
BF25_5140	COG2855	membrane
BF25_5144	COG0789	Transcriptional regulator
BF25_5148	COG0556	nucleotide-excision repair
BF25_5149	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BF25_5151	COG1950	PFAM Membrane protein of
BF25_5155	COG0110	maltose O-acetyltransferase activity
BF25_5156	COG0457	Tetratricopeptide repeat
BF25_5157	COG0492	ferredoxin-NADP+ reductase activity
BF25_5159	COG1051	belongs to the nudix hydrolase family
BF25_516	COG0511	ligase activity, forming carbon-carbon bonds
BF25_5161	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BF25_5163	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BF25_5164	COG0740	serine-type endopeptidase activity
BF25_5165	COG2323	membrane
BF25_5168	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_517	COG0439	Biotin carboxylase
BF25_5173	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BF25_5176	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BF25_5178	COG0149	triose-phosphate isomerase activity
BF25_5179	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BF25_518	COG1302	Protein conserved in bacteria
BF25_5181	COG4974	Belongs to the 'phage' integrase family
BF25_5186	COG4695	Portal protein
BF25_52	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BF25_5205	COG1346	cytolysis
BF25_5206	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BF25_5207	COG1647	Serine aminopeptidase, S33
BF25_5208	COG0557	exoribonuclease II activity
BF25_5217	COG3223	Belongs to the PsiE family
BF25_5218	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_5221	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BF25_5222	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BF25_5224	COG3290	protein histidine kinase activity
BF25_5224	COG0840	transmembrane signaling receptor activity
BF25_5226	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BF25_5227	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BF25_5228	COG1252	NADH dehydrogenase
BF25_523	COG0142	geranyltranstransferase activity
BF25_5230	COG1733	regulation of RNA biosynthetic process
BF25_5231	COG2814	Major facilitator Superfamily
BF25_5232	COG0656	L-ascorbic acid biosynthetic process
BF25_5237	COG2910	NAD(P)H-binding
BF25_5238	COG1115	amino acid carrier protein
BF25_5239	COG1115	amino acid carrier protein
BF25_5240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_5241	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BF25_5243	COG2311	Membrane
BF25_5246	COG1611	Belongs to the LOG family
BF25_5249	COG0783	Belongs to the Dps family
BF25_525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BF25_5250	COG1115	amino acid carrier protein
BF25_5251	COG0490	domain, Protein
BF25_5252	COG0475	glutathione-regulated potassium exporter activity
BF25_5255	COG1741	Belongs to the pirin family
BF25_5256	COG3227	Zinc metalloprotease (Elastase)
BF25_5257	COG2151	metal-sulfur cluster biosynthetic enzyme
BF25_5260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BF25_5262	COG5002	protein histidine kinase activity
BF25_5263	COG0745	RESPONSE REGULATOR receiver
BF25_5264	COG1376	ErfK ybiS ycfS ynhG family protein
BF25_5266	COG0586	Pfam SNARE associated Golgi protein
BF25_527	COG0497	DNA recombination
BF25_5273	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_5275	COG0706	membrane insertase activity
BF25_5277	COG0531	amino acid
BF25_5278	COG2814	Major facilitator Superfamily
BF25_528	COG0750	zinc metalloprotease
BF25_5282	COG0840	transmembrane signaling receptor activity
BF25_5283	COG0011	TIGRFAM Protein of
BF25_5286	COG1686	Belongs to the peptidase S11 family
BF25_5288	COG1250	3-hydroxyacyl-CoA dehydrogenase
BF25_5288	COG1024	Enoyl-CoA hydratase
BF25_5289	COG0183	Belongs to the thiolase family
BF25_529	COG0745	RESPONSE REGULATOR receiver
BF25_5290	COG1960	acyl-CoA dehydrogenase activity
BF25_5291	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_5292	COG1309	transcriptional regulator
BF25_5297	COG0039	L-malate dehydrogenase activity
BF25_5306	COG1393	Belongs to the ArsC family
BF25_5308	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BF25_5309	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BF25_531	COG3093	addiction module antidote protein HigA
BF25_5311	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BF25_5312	COG2011	ABC-type metal ion transport system permease component
BF25_5313	COG1464	Belongs to the NlpA lipoprotein family
BF25_5314	COG1464	Belongs to the NlpA lipoprotein family
BF25_5315	COG0396	ATPase activity
BF25_5316	COG0719	Fe-S assembly protein
BF25_5317	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BF25_5318	COG0822	iron-sulfur transferase activity
BF25_5319	COG0719	Fe-S assembly protein
BF25_532	COG0584	glycerophosphoryl diester phosphodiesterase
BF25_5321	COG1695	Transcriptional regulator
BF25_5322	COG0737	Belongs to the 5'-nucleotidase family
BF25_5323	COG3377	Domain of unknown function (DUF1805)
BF25_5325	COG0739	heme binding
BF25_5330	COG4377	Putative membrane peptidase family (DUF2324)
BF25_5331	COG0789	Transcriptional regulator
BF25_5333	COG4470	Protein conserved in bacteria
BF25_5336	COG1494	fructose-1,6-bisphosphatase
BF25_5337	COG2445	Protein of unknown function DUF86
BF25_5339	COG0647	UMP catabolic process
BF25_534	COG3829	transcription factor binding
BF25_534	COG3290	protein histidine kinase activity
BF25_5340	COG2249	NAD(P)H dehydrogenase (quinone) activity
BF25_5342	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BF25_5343	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BF25_5345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BF25_5346	COG4837	Protein of unknown function (DUF1462)
BF25_535	COG0280	phosphate acetyltransferase
BF25_5354	COG2824	Alkylphosphonate utilization operon protein PhnA
BF25_5355	COG0390	transport system, permease component
BF25_5357	COG1252	NADH dehydrogenase
BF25_536	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BF25_5360	COG0316	Belongs to the HesB IscA family
BF25_5363	COG1683	Conserved Protein
BF25_5366	COG3708	Transcriptional regulator
BF25_5370	COG1252	NADH dehydrogenase
BF25_5373	COG3584	3D domain protein
BF25_5376	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BF25_5377	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BF25_5379	COG1268	BioY protein
BF25_538	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BF25_5381	COG2050	protein possibly involved in aromatic compounds catabolism
BF25_5382	COG0423	glycine-tRNA ligase activity
BF25_5385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BF25_5386	COG5018	Exonuclease
BF25_539	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF25_5390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BF25_5392	COG2267	carboxylic ester hydrolase activity
BF25_5393	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF25_5394	COG1522	sequence-specific DNA binding
BF25_5395	COG0436	Aminotransferase
BF25_5396	COG1098	S1 RNA binding domain
BF25_5397	COG2155	Conserved Protein
BF25_5398	COG0166	Belongs to the GPI family
BF25_5399	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BF25_54	COG3874	Sporulation protein YtfJ
BF25_540	COG0022	dehydrogenase e1 component
BF25_5401	COG1285	pathogenesis
BF25_5409	COG0544	peptidyl-prolyl cis-trans isomerase activity
BF25_541	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF25_542	COG0772	Belongs to the SEDS family
BF25_5428	COG0039	L-malate dehydrogenase activity
BF25_543	COG2816	NAD+ diphosphatase activity
BF25_5430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BF25_5431	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BF25_5432	COG0297	glycogen (starch) synthase activity
BF25_5433	COG0058	SHG alpha-glucan phosphorylase activity
BF25_5437	COG1278	Cold shock
BF25_5438	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BF25_5439	COG1575	Belongs to the MenA family. Type 1 subfamily
BF25_5440	COG1169	isochorismate synthase
BF25_5441	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BF25_5442	COG0596	Alpha beta hydrolase
BF25_5443	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BF25_5445	COG4948	Mandelate Racemase Muconate Lactonizing
BF25_5451	COG3964	amidohydrolase
BF25_5458	COG0577	efflux transmembrane transporter activity
BF25_5459	COG0577	efflux transmembrane transporter activity
BF25_546	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BF25_5460	COG1136	(ABC) transporter
BF25_5461	COG0577	efflux transmembrane transporter activity
BF25_5462	COG0577	efflux transmembrane transporter activity
BF25_5464	COG0577	efflux transmembrane transporter activity
BF25_5465	COG2205	protein histidine kinase activity
BF25_5466	COG0745	RESPONSE REGULATOR receiver
BF25_5467	COG3708	Transcriptional regulator
BF25_5467	COG2207	Transcriptional regulator
BF25_5468	COG1136	(ABC) transporter
BF25_5469	COG0577	efflux transmembrane transporter activity
BF25_547	COG0765	amino acid transport
BF25_5471	COG0586	Pfam SNARE associated Golgi protein
BF25_5478	COG1597	lipid kinase activity
BF25_548	COG1126	abc transporter atp-binding protein
BF25_5484	COG0745	RESPONSE REGULATOR receiver
BF25_5485	COG5002	protein histidine kinase activity
BF25_549	COG4129	membrane
BF25_5492	COG1842	Phage shock protein A
BF25_5497	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_55	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BF25_550	COG1376	ErfK ybiS ycfS ynhG family protein
BF25_5501	COG1294	oxidase, subunit
BF25_5502	COG1271	oxidase subunit
BF25_5504	COG0288	reversible hydration of carbon dioxide
BF25_5509	COG0494	nUDIX hydrolase
BF25_5511	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BF25_5515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BF25_5516	COG1116	anion transmembrane transporter activity
BF25_5517	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BF25_552	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_5521	COG1368	sulfuric ester hydrolase activity
BF25_5522	COG2267	carboxylic ester hydrolase activity
BF25_5523	COG4191	Histidine kinase
BF25_5524	COG5002	protein histidine kinase activity
BF25_5525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BF25_553	COG2195	Cleaves the N-terminal amino acid of tripeptides
BF25_5535	COG0521	Mo-molybdopterin cofactor biosynthetic process
BF25_5537	COG0438	transferase activity, transferring glycosyl groups
BF25_5538	COG0671	phosphoesterase, PA-phosphatase related
BF25_5539	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BF25_5540	COG2267	carboxylic ester hydrolase activity
BF25_5544	COG1794	racemase activity, acting on amino acids and derivatives
BF25_5546	COG1131	(ABC) transporter
BF25_5547	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BF25_5548	COG1242	4 iron, 4 sulfur cluster binding
BF25_555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BF25_5552	COG1136	(ABC) transporter
BF25_5554	COG0582	viral genome integration into host DNA
BF25_5555	COG0490	domain, Protein
BF25_5556	COG0475	glutathione-regulated potassium exporter activity
BF25_5557	COG2814	Major facilitator Superfamily
BF25_5565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BF25_5567	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BF25_5571	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BF25_5572	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BF25_5574	COG0303	'Molybdopterin
BF25_5575	COG1763	Mo-molybdopterin cofactor biosynthetic process
BF25_5576	COG0314	molybdopterin synthase activity
BF25_5579	COG4975	Glucose uptake
BF25_558	COG1760	l-serine dehydratase
BF25_5581	COG1329	Transcriptional regulator
BF25_5585	COG3832	glyoxalase III activity
BF25_5587	COG2814	Major facilitator Superfamily
BF25_5588	COG2081	HI0933 family
BF25_5589	COG2244	polysaccharide biosynthetic process
BF25_559	COG1760	l-serine dehydratase
BF25_5590	COG1187	pseudouridine synthase activity
BF25_5591	COG1349	DNA-binding transcription factor activity
BF25_5592	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF25_5593	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BF25_5595	COG1523	belongs to the glycosyl hydrolase 13 family
BF25_5596	COG0510	thiamine kinase activity
BF25_5599	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_56	COG0827	DNA restriction-modification system
BF25_560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BF25_5601	COG1363	Peptidase, m42
BF25_5607	COG2311	Membrane
BF25_562	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BF25_563	COG0300	oxidoreductase activity
BF25_5636	COG4962	Type ii secretion system protein e
BF25_566	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BF25_568	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BF25_5680	COG3344	reverse transcriptase
BF25_57	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BF25_5702	COG3344	reverse transcriptase
BF25_572	COG1522	sequence-specific DNA binding
BF25_5723	COG1923	regulation of RNA biosynthetic process
BF25_5725	COG0457	Tetratricopeptide repeat
BF25_5730	COG4974	Belongs to the 'phage' integrase family
BF25_5732	COG3443	Belongs to the bacterial solute-binding protein 9 family
BF25_5734	COG2801	Transposase and inactivated derivatives
BF25_5737	COG2801	Transposase and inactivated derivatives
BF25_574	COG0737	Belongs to the 5'-nucleotidase family
BF25_5746	COG4974	Belongs to the 'phage' integrase family
BF25_5748	COG2002	toxin-antitoxin pair type II binding
BF25_577	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BF25_5783	COG2801	Transposase and inactivated derivatives
BF25_5786	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BF25_5787	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BF25_579	COG0156	8-amino-7-oxononanoate synthase activity
BF25_5791	COG0671	phosphoesterase, PA-phosphatase related
BF25_5799	COG1280	lysine exporter protein (LysE YggA)
BF25_580	COG1073	alpha beta
BF25_580	COG2226	methyltransferase
BF25_5807	COG0681	Belongs to the peptidase S26 family
BF25_581	COG4106	trans-aconitate 2-methyltransferase activity
BF25_582	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BF25_5824	COG1309	transcriptional regulator
BF25_5825	COG1683	Conserved Protein
BF25_5832	COG2801	Transposase and inactivated derivatives
BF25_5836	COG1192	Involved in chromosome partitioning
BF25_586	COG0307	riboflavin synthase, alpha
BF25_587	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF25_587	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BF25_5870	COG0741	lytic transglycosylase activity
BF25_5870	COG0791	NLP P60 protein
BF25_5883	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF25_5884	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF25_5894	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BF25_590	COG1073	alpha beta
BF25_591	COG0456	acetyltransferase
BF25_592	COG1609	Transcriptional regulator
BF25_593	COG2056	Na+-H+ antiporter family
BF25_594	COG0596	Alpha beta hydrolase
BF25_596	COG0737	Belongs to the 5'-nucleotidase family
BF25_596	COG4085	toxin activity
BF25_596	COG1525	nuclease
BF25_598	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BF25_598	COG0456	acetyltransferase
BF25_599	COG0656	L-ascorbic acid biosynthetic process
BF25_6	COG1674	ftsk spoiiie
BF25_600	COG0667	Aldo Keto reductase
BF25_604	COG1300	Membrane
BF25_605	COG0735	belongs to the Fur family
BF25_607	COG4974	Belongs to the 'phage' integrase family
BF25_61	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BF25_612	COG0598	Magnesium transport protein CorA
BF25_615	COG1846	Transcriptional regulator
BF25_618	COG1131	(ABC) transporter
BF25_619	COG1725	Transcriptional regulator
BF25_620	COG1686	Belongs to the peptidase S11 family
BF25_624	COG0733	neurotransmitter:sodium symporter activity
BF25_629	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BF25_632	COG0697	spore germination
BF25_633	COG0561	phosphatase activity
BF25_634	COG4086	secreted protein
BF25_635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BF25_636	COG0456	acetyltransferase
BF25_637	COG1547	Domain of unknown function (DUF309)
BF25_642	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BF25_646	COG3711	transcriptional antiterminator
BF25_647	COG2190	(PTS) system
BF25_647	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BF25_647	COG1263	PTS System
BF25_652	COG0778	Nitroreductase
BF25_653	COG3706	GGDEF domain
BF25_654	COG2084	Dehydrogenase
BF25_655	COG2084	Dehydrogenase
BF25_658	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BF25_662	COG0436	Aminotransferase
BF25_663	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BF25_667	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_668	COG1695	Transcriptional regulator
BF25_675	COG0183	Belongs to the thiolase family
BF25_683	COG3842	ATPase activity
BF25_684	COG0366	Alpha amylase catalytic
BF25_686	COG2182	Extracellular solute-binding protein
BF25_687	COG1175	transmembrane transport
BF25_688	COG3833	ABC-type maltose transport systems, permease component
BF25_689	COG1609	Transcriptional regulator
BF25_690	COG0436	Aminotransferase
BF25_692	COG2205	protein histidine kinase activity
BF25_694	COG3209	COG3209 Rhs family protein
BF25_698	COG2814	Major facilitator Superfamily
BF25_70	COG0589	response to stress
BF25_705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BF25_707	COG1408	metallophosphoesterase
BF25_708	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_709	COG2200	EAL domain
BF25_71	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_712	COG4703	Protein of unknown function (DUF1797)
BF25_714	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BF25_716	COG0517	IMP dehydrogenase activity
BF25_717	COG0583	DNA-binding transcription factor activity
BF25_721	COG0569	domain protein
BF25_722	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF25_724	COG0561	phosphatase activity
BF25_725	COG0242	peptide deformylase activity
BF25_727	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BF25_728	COG0022	dehydrogenase e1 component
BF25_729	COG0508	dehydrogenase complex catalyzes the overall conversion of
BF25_738	COG1982	Orn Lys Arg decarboxylase major
BF25_74	COG1476	TRANSCRIPTIONal
BF25_742	COG0483	inositol monophosphate 1-phosphatase activity
BF25_747	COG4896	Protein conserved in bacteria
BF25_749	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BF25_750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BF25_751	COG4838	Belongs to the UPF0358 family
BF25_752	COG0772	Belongs to the SEDS family
BF25_753	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BF25_76	COG0662	Cupin 2, conserved barrel domain protein
BF25_760	COG3336	cytochrome c oxidase
BF25_763	COG2340	Cysteine-rich secretory protein family
BF25_766	COG0406	alpha-ribazole phosphatase activity
BF25_767	COG3679	Belongs to the UPF0342 family
BF25_77	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_771	COG0742	ribosomal rna small subunit methyltransferase
BF25_772	COG3314	Sporulation integral membrane protein YlbJ
BF25_774	COG1752	Esterase of the alpha-beta hydrolase superfamily
BF25_775	COG3480	Lon protease (S16) C-terminal proteolytic domain
BF25_777	COG0582	viral genome integration into host DNA
BF25_781	COG1396	sequence-specific DNA binding
BF25_785	COG1396	sequence-specific DNA binding
BF25_791	COG1484	DNA-dependent DNA replication
BF25_796	COG1191	sigma factor activity
BF25_811	COG0582	viral genome integration into host DNA
BF25_816	COG4626	Terminase
BF25_816	COG1802	Transcriptional regulator
BF25_836	COG4824	toxin secretion phage lysis holin
BF25_84	COG0006	proline dipeptidase activity
BF25_846	COG1399	metal-binding, possibly nucleic acid-binding protein
BF25_850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BF25_853	COG4839	cell division protein FtsL
BF25_855	COG0768	penicillin binding
BF25_856	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BF25_859	COG0772	Belongs to the SEDS family
BF25_860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BF25_861	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BF25_862	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BF25_863	COG0849	cell division
BF25_864	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BF25_866	COG1191	sigma factor activity
BF25_867	COG1191	sigma factor activity
BF25_868	COG1873	PFAM PRC-barrel domain
BF25_87	COG4109	DRTGG domain
BF25_870	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BF25_872	COG0762	integral membrane protein
BF25_873	COG2302	S4 RNA-binding domain
BF25_874	COG3599	regulation of cell shape
BF25_875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BF25_878	COG0564	pseudouridine synthase activity
BF25_883	COG0505	Belongs to the CarA family
BF25_891	COG3069	C4-dicarboxylate transmembrane transporter activity
BF25_894	COG0006	proline dipeptidase activity
BF25_896	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BF25_897	COG1561	YicC-like family, N-terminal region
BF25_899	COG0194	GDP metabolic process
BF25_9	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BF25_901	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BF25_902	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BF25_903	COG0242	peptide deformylase activity
BF25_905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BF25_905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BF25_907	COG0631	protein serine/threonine phosphatase activity
BF25_908	COG0515	serine threonine protein kinase
BF25_908	COG2815	serine threonine protein kinase
BF25_909	COG1162	GTPase activity
BF25_91	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BF25_910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BF25_911	COG1564	THIamine pyrophosphokinase
BF25_913	COG1302	Protein conserved in bacteria
BF25_914	COG1461	Dihydroxyacetone kinase
BF25_915	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BF25_918	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BF25_919	COG1028	Short-chain dehydrogenase reductase Sdr
BF25_922	COG1196	nuclear chromosome segregation
BF25_923	COG0552	protein localization to endoplasmic reticulum
BF25_925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BF25_927	COG1837	Belongs to the UPF0109 family
BF25_935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BF25_937	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BF25_939	COG4974	Belongs to the 'phage' integrase family
BF25_94	COG0587	DNA-directed DNA polymerase activity
BF25_945	COG0528	UMP kinase activity
BF25_947	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BF25_948	COG4589	Belongs to the CDS family
BF25_949	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BF25_95	COG0281	malic enzyme
BF25_950	COG0750	zinc metalloprotease
BF25_954	COG0195	Participates in both transcription termination and antitermination
BF25_955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BF25_956	COG1358	cellular component organization or biogenesis
BF25_958	COG1550	Protein conserved in bacteria
BF25_96	COG1725	Transcriptional regulator
BF25_960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BF25_961	COG0196	riboflavin kinase activity
BF25_964	COG0726	polysaccharide deacetylase
BF25_965	COG0612	Peptidase, M16
BF25_966	COG1873	PFAM PRC-barrel domain
BF25_967	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BF25_968	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BF25_969	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BF25_970	COG0527	aspartate kinase activity
BF25_972	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BF25_973	COG0740	serine-type endopeptidase activity
BF25_975	COG1674	ftsk spoiiie
BF25_976	COG2188	Transcriptional regulator
BF25_982	COG0612	Peptidase, M16
BF25_983	COG0612	Peptidase, M16
BF25_984	COG0300	oxidoreductase activity
BF25_987	COG1426	Protein conserved in bacteria
BF25_988	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BF25_993	COG1692	metallophosphoesterase
BF25_994	COG2359	stage V sporulation protein S
BF25_996	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BF25_996	COG0674	pyruvate-flavodoxin oxidoreductase activity
BF25_997	COG1013	pyruvate-flavodoxin oxidoreductase activity
BF25_998	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BF25_999	COG4550	Control of competence regulator ComK, YlbF/YmcA