locus-tag class description TD69_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TD69_00015 ENOG410848D S4 domain protein YaaA TD69_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TD69_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) TD69_00100 ENOG4105ZMH deoxynucleoside kinase TD69_00110 ENOG4105GTG Isochorismatase TD69_00120 ENOG4108Z6B deaminase TD69_00125 ENOG4105C6E dna polymerase iii TD69_00145 ENOG41067KS pro-sigma K processing TD69_00180 ENOG4105CXN decarboxylase TD69_00190 ENOG4105FA2 dna polymerase iii TD69_00195 ENOG4105MA4 psp1 domain protein TD69_00205 ENOG41060K3 Methyltransferase TD69_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) TD69_00220 ENOG4105KRN Transcriptional regulator, abrb family TD69_00230 ENOG4105F8V Hydrolase, tatD family TD69_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) TD69_00245 ENOG4105XFA sporulation peptidase YabG TD69_00250 ENOG4105W42 Veg protein TD69_00265 ENOG4105DFT pur operon repressor TD69_00270 ENOG4105KME endoribonuclease L-psp TD69_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase TD69_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) TD69_00300 ENOG4108JA2 transcriptioN-repair coupling factor TD69_00305 ENOG4108M14 stage v sporulation protein t TD69_00315 ENOG4108IY2 MazG family TD69_00320 ENOG41082I2 s4 domain protein TD69_00325 ENOG4105VYY sporulation protein yabp TD69_00340 ENOG41060GV RNA binding s1 domain protein TD69_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) TD69_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase TD69_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) TD69_00385 ENOG4105C6T cysteine synthase TD69_00390 ENOG4105CRQ synthase (Component I) TD69_00395 ENOG4105DDQ anthranilate synthase TD69_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 TD69_00405 ENOG4105EEI dihydropteroate synthase TD69_00410 ENOG4105KRF dihydroneopterin aldolase TD69_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase TD69_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) TD69_00455 ENOG4108Z0C Uvrb UvrC protein TD69_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) TD69_00480 ENOG4105CTP PilT protein domain protein TD69_00500 ENOG4105D7W serine acetyltransferase TD69_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 TD69_00520 ENOG4105M0M Tetracycline resistance protein TD69_00525 ENOG4105QIV RNA polymerase TD69_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) TD69_00565 ENOG4107Y49 methyltransferase TD69_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) TD69_00580 ENOG4105XPM ribosomal protein TD69_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) TD69_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TD69_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TD69_00730 ENOG41067V7 50S ribosomal protein L36 TD69_00760 ENOG4108JJB ABC transporter TD69_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) TD69_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TD69_00795 ENOG4105D1F ATP-binding protein TD69_00810 ENOG4108NMV polysaccharide deacetylase TD69_00895 ENOG4105C8B TIGR00159 family TD69_00900 ENOG4107U5W ybbr family TD69_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) TD69_00920 ENOG4108VQT Alpha beta hydrolase fold protein TD69_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) TD69_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein TD69_00980 ENOG4108PSK reductase TD69_00985 ENOG4108UMI ABC transporter, permease TD69_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TD69_00995 ENOG4105D01 (LipO)protein TD69_01000 ENOG4105EE1 crotonyl-CoA reductase TD69_01010 ENOG4105IQ5 FAD linked oxidase domain protein TD69_01025 ENOG4105C2C drug resistance transporter, Bcr CflA TD69_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TD69_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD69_01050 ENOG4105C3U ABC transporter TD69_01055 ENOG4108JQ7 (ABC) transporter TD69_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 TD69_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 TD69_01100 ENOG4105II7 pyrroline-5-carboxylate reductase TD69_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter TD69_01120 ENOG4105E0C molybdate abc transporter TD69_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein TD69_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein TD69_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family TD69_01150 ENOG4105EGI Transcriptional regulator TD69_01165 ENOG4105F6E Acyl-transferase TD69_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) TD69_01200 ENOG4108RE7 deoxyribonuclease TD69_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) TD69_01230 ENOG4105C5H ABC transporter TD69_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein TD69_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD69_01260 ENOG4105C3U ABC transporter TD69_01265 ENOG4108JQ7 (ABC) transporter TD69_01290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase TD69_01295 ENOG4105ERH Fumarylacetoacetate hydrolase TD69_01305 ENOG4108SC4 )-transporter TD69_01310 ENOG4105CPF Cell wall formation (By similarity) TD69_01315 ENOG4105CPF Cell wall formation (By similarity) TD69_01320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TD69_01335 ENOG4107ZXI Rhomboid family TD69_01345 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein TD69_01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TD69_01360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) TD69_01460 ENOG4105K8N protein family UPF0079, ATPase TD69_01465 ENOG41072GX Peptidase M22 Glycoprotease TD69_01470 ENOG410801F ribosomal-protein-alanine acetyltransferase TD69_01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TD69_01480 ENOG4105C5H ABC transporter TD69_01495 ENOG4108TYN CAAX amino terminal protease family protein TD69_01515 ENOG4105C7N Xanthine uracil vitamin C permease TD69_01525 ENOG4105BZU Histidine kinase TD69_01555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TD69_01595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TD69_01615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) TD69_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit TD69_01645 ENOG4105C83 adenylosuccinate lyase TD69_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase TD69_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase TD69_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase TD69_01715 ENOG4105C4R Atp-dependent dna helicase TD69_01745 ENOG4108W2Y isochorismatase TD69_01750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TD69_01755 ENOG4108UMI ABC transporter, permease TD69_01760 ENOG4105D01 (LipO)protein TD69_01780 ENOG410834F Transcriptional regulator TD69_01805 ENOG4105CBD Diacylglycerol kinase TD69_01810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) TD69_01815 ENOG4108JPW Aminotransferase TD69_01825 ENOG4105C26 Dehydrogenase TD69_01830 ENOG4105KPY Small multidrug resistance protein TD69_01850 ENOG4105D9N nucleoside TD69_01855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TD69_01870 ENOG4108W15 Protein of unknown function (DUF1456) TD69_01885 ENOG4105DTQ mandelate racemase muconate lactonizing TD69_01895 ENOG4105DFD Na H antiporter TD69_01915 ENOG4105D3R alkyl hydroperoxide reductase TD69_01920 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) TD69_01930 ENOG4107W7X Aldolase TD69_01935 ENOG4105EHG Permease protein TD69_01940 ENOG4105DQ5 transport system permease protein TD69_01945 ENOG4108V5C ABC transporter TD69_01970 ENOG4106UIA TD69_01975 ENOG4106UIA TD69_02000 ENOG4105BZU Histidine kinase TD69_02020 ENOG410756H nucleotidyltransferase TD69_02025 ENOG4105D2S major facilitator superfamily TD69_02040 ENOG4105E5Q amino acid AbC transporter TD69_02045 ENOG4105EAB amino acid AbC transporter TD69_02060 ENOG4105C8Q Methyl-accepting chemotaxis TD69_02065 ENOG4105C8Q Methyl-accepting chemotaxis TD69_02075 ENOG4105CI1 PTS System TD69_02105 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter TD69_02120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component TD69_02135 ENOG4105C5H ABC transporter TD69_02160 ENOG41062JF Transcriptional regulator TD69_02180 ENOG4105DEU major facilitator superfamily TD69_02195 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) TD69_02210 ENOG4108N0M stress protein TD69_02215 ENOG4106FN3 tellurium resistance protein TD69_02220 ENOG4106FN3 tellurium resistance protein TD69_02225 ENOG4107TS3 membrane protein, TerC TD69_02230 ENOG4108TTB tellurium resistance protein TD69_02250 ENOG4105KJF protein tyrosine phosphatase TD69_02260 ENOG4107U9T Pfam:Ribonuclease_BN TD69_02265 ENOG4105C59 p-type ATPase TD69_02270 ENOG4108IPJ Membrane TD69_02290 ENOG4107ZTW SNARE associated Golgi TD69_02305 ENOG410606W general stress protein TD69_02310 ENOG4105UPD Calcium Proton TD69_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) TD69_02355 ENOG4105VTR Integrase TD69_02360 ENOG4108IMY Transcriptional regulator TD69_02635 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) TD69_02645 ENOG4108JUB Transcriptional regulator TD69_02655 ENOG4108IQI permease TD69_02690 ENOG4105CSV Glutaminase TD69_02700 ENOG4108A04 Beta-lactamase TD69_02715 ENOG4105CKK Glycosyl transferase, family 2 TD69_02725 ENOG4107QQG Dehydrogenase TD69_02730 ENOG4105C3I Nad-dependent epimerase dehydratase TD69_02750 ENOG4105F1A Pyruvate formate-lyase TD69_02770 ENOG4105CI2 imidazolone-5-propionate hydrolase TD69_02775 ENOG4105ECP epimerase TD69_02805 ENOG41067AE Membrane-bound metal-dependent hydrolase TD69_02810 ENOG4105CEN a g-specific adenine glycosylase TD69_02815 ENOG4106BXE TD69_02835 ENOG4105BZ1 (ABC) transporter TD69_02840 ENOG4107NBY Membrane TD69_02845 ENOG4105CBC glutamate synthase TD69_02855 ENOG4108IUW ABC transporter TD69_02875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TD69_02880 ENOG4105G5W regulator Fur family TD69_02995 ENOG4108JQC penicillin-binding protein 1A TD69_03000 ENOG4107ZQN disulfide bond TD69_03010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) TD69_03020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) TD69_03025 ENOG4105BZU Histidine kinase TD69_03035 ENOG4105CYN Serine protein kinase TD69_03060 ENOG4105C94 Transporter TD69_03075 ENOG4105DZ6 Band 7 protein TD69_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism TD69_03095 ENOG4105D4T Citrate transporter TD69_03115 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator TD69_03120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TD69_03125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component TD69_03130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component TD69_03135 ENOG4105BZ7 extracellular solute-binding protein family 1 TD69_03140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) TD69_03145 ENOG4108STX response regulator TD69_03150 ENOG4105US7 Histidine kinase TD69_03175 ENOG4108MRH transcriptional regulatory protein TD69_03185 ENOG4105C6K Malic enzyme TD69_03195 ENOG4108UZ3 Transporter TD69_03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD69_03210 ENOG4105BZU Histidine kinase TD69_03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_03225 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) TD69_03230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TD69_03235 ENOG4108JB9 formate dehydrogenase TD69_03255 ENOG4105CUB amino acid TD69_03265 ENOG4105C59 p-type ATPase TD69_03270 ENOG4105DAP Nicotinate phosphoribosyltransferase TD69_03300 ENOG41073R8 VanW family TD69_03305 ENOG4108KGH TRANSCRIPTIONal TD69_03310 ENOG4105D9N nucleoside TD69_03315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase TD69_03320 ENOG4105C37 (CBS) domain TD69_03325 ENOG4108IJ0 Aspartate ammonia-lyase TD69_03330 ENOG4105DAA L-lactate TD69_03345 ENOG4105DUX Transporter TD69_03350 ENOG4108MES Periplasmic binding protein TD69_03355 ENOG4105DQ5 transport system permease protein TD69_03360 ENOG4108IHU transport system permease protein TD69_03365 ENOG4105E0A ABC, transporter TD69_03370 ENOG4105DMQ Methyltransferase TD69_03380 ENOG4105EXW epimerase dehydratase TD69_03390 ENOG4107T89 von Willebrand factor, type A TD69_03395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 TD69_03400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TD69_03415 ENOG4105BZU Histidine kinase TD69_03420 ENOG4105D5Q Arginine ornithine antiporter TD69_03425 ENOG4107414 GntR family transcriptional regulator TD69_03430 ENOG4105C5Y PTS System TD69_03435 ENOG4105CG3 alpha amylase, catalytic region TD69_03450 ENOG4105E1K spore germination protein TD69_03460 ENOG4105CRN Aminoglycoside phosphotransferase TD69_03465 ENOG4105BZG amino acid carrier protein TD69_03470 ENOG4105CDA abc transporter atp-binding protein TD69_03475 ENOG4105CT1 (ABC) transporter TD69_03480 ENOG4105EAD ABC transporter TD69_03485 ENOG4105DRP amino acid AbC transporter TD69_03490 ENOG4108IQI permease TD69_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein TD69_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein TD69_03525 ENOG4105BZU Histidine kinase TD69_03540 ENOG4105CHH sulfate transporter TD69_03545 ENOG41068KF Universal stress protein TD69_03555 ENOG4105DEF Extracellular solute-binding protein, family 5 TD69_03565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TD69_03570 ENOG4108JQ7 (ABC) transporter TD69_03580 ENOG4105CXY transporter TD69_03585 ENOG41067TZ transcriptional regulator, MarR family TD69_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_03600 ENOG4105ETE Transcriptional regulator (LacI family TD69_03605 ENOG4108RVA ribokinase TD69_03615 ENOG4105C2J ABC transporter TD69_03620 ENOG4105CNN ABC, transporter TD69_03625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator TD69_03630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TD69_03690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TD69_03695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TD69_03700 ENOG41069ER domain protein TD69_03705 ENOG4105VZ8 Transcriptional regulator TD69_03710 ENOG4107D63 TD69_03720 ENOG4105DUX Transporter TD69_03740 ENOG4105C85 amino acid TD69_03745 ENOG4105C7N Xanthine uracil vitamin C permease TD69_03785 ENOG4105BZ9 Cytochrome C oxidase, subunit I TD69_03790 ENOG4105E2S oxidase) subunit II TD69_03795 ENOG4108IQI permease TD69_03810 ENOG4106CAD Protein of unknown function (DUF3311) TD69_03815 ENOG4105E1V na solute symporter TD69_03830 ENOG4108NHD germination protein TD69_03840 ENOG4105CE1 Ferrous iron transport protein b TD69_03845 ENOG4105CE1 Ferrous iron transport protein b TD69_03850 ENOG4105CE1 Ferrous iron transport protein b TD69_03855 ENOG4105CVA phosphate TD69_03860 ENOG4105C8U phosphate abc transporter TD69_03865 ENOG4105E2Z phosphate ABC transporter (Permease TD69_03990 ENOG41080XQ Signal transduction protein with cbs domains TD69_04015 ENOG4105ETU transcriptional activator (TenA TD69_04025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component TD69_04035 ENOG4108VEU Thiamine monophosphate synthase TD69_04040 ENOG41080HI glycine oxidase TD69_04055 ENOG4105D06 uba thif-type nad fad binding protein TD69_04060 ENOG4105DWF phosphomethylpyrimidine kinase TD69_04110 ENOG4108INS Transcriptional regulator TD69_04125 ENOG4105C7N Xanthine uracil vitamin C permease TD69_04155 ENOG4105C5Y PTS System TD69_04215 ENOG4107Y03 Nitroreductase TD69_04220 ENOG4105ED1 spovr family TD69_04245 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase TD69_04250 ENOG4105XTG Pfam:DUF156 TD69_04255 ENOG4105VFE sira family TD69_04260 ENOG4107TPS domain protein TD69_04265 ENOG4105VFE sira family TD69_04270 ENOG41085GJ domain protein TD69_04280 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase TD69_04285 ENOG41087NI Sulfite exporter TauE/SafE TD69_04295 ENOG4108KGH TRANSCRIPTIONal TD69_04320 ENOG4105EMD TRANSCRIPTIONal TD69_04325 ENOG4105VCP PTS System TD69_04330 ENOG4105VZJ PTS System TD69_04350 ENOG41069ER domain protein TD69_04355 ENOG4107RBB ABC transporter, permease TD69_04360 ENOG4105C19 ABC transporter TD69_04390 ENOG4105WEF catalase TD69_04425 ENOG4107T5V SNARE associated Golgi TD69_04460 ENOG4105CUB amino acid TD69_04465 ENOG4107RWR Sodium hydrogen exchanger TD69_04475 ENOG4106KNT transcriptional regulator TD69_04510 ENOG4108PCN EamA-like transporter family TD69_04515 ENOG4108YXU transcriptional regulator AsnC family TD69_04525 ENOG4105KPY Small multidrug resistance protein TD69_04530 ENOG4105KPY Small multidrug resistance protein TD69_04555 ENOG4105NF4 modulator of drug activity TD69_04560 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) TD69_04565 ENOG4105E5W Transporter TD69_04575 ENOG4107RKG DJ-1/PfpI family TD69_04580 ENOG4105CH6 catalase TD69_04590 ENOG4105D5Q Arginine ornithine antiporter TD69_04595 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) TD69_04605 ENOG4105C26 Dehydrogenase TD69_04615 ENOG4105BZ1 (ABC) transporter TD69_04630 ENOG4105DRP amino acid AbC transporter TD69_04635 ENOG4105CDA abc transporter atp-binding protein TD69_04650 ENOG410839P TD69_04685 ENOG4107FQX Alpha-acetolactate decarboxylase TD69_04715 ENOG4105D4P Coproporphyrinogen iii oxidase TD69_04730 ENOG4105CHH sulfate transporter TD69_04770 ENOG4106AKK s-layer domain-containing protein TD69_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TD69_04785 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TD69_04800 ENOG4105CGU Enoyl-CoA hydratase TD69_04820 ENOG4105DER m42 family TD69_04840 ENOG4105CTU Proline racemase TD69_04885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD69_04895 ENOG4108JQ7 (ABC) transporter TD69_04925 ENOG4105CSH Transporter TD69_04935 ENOG4108MRH transcriptional regulatory protein TD69_04985 ENOG4105CDU Replicative dna helicase TD69_05025 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_05075 ENOG4107P5I polyketide synthase TD69_05080 ENOG4108IG5 Transcriptional regulator TD69_05100 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase TD69_05120 ENOG4105CMT Dihydroxyacetone kinase TD69_05130 ENOG4105CMT Dihydroxyacetone kinase TD69_05135 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TD69_05140 ENOG410847I Transcriptional regulator, BadM Rrf2 family TD69_05165 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase TD69_05230 ENOG4105WN5 stage II sporulation protein TD69_05240 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_05250 ENOG4108MJI response regulator TD69_05255 ENOG4105BZU Histidine kinase TD69_05260 ENOG4105BZU Histidine kinase TD69_05320 ENOG4107VRP DNA repair exonuclease TD69_05325 ENOG4106D4I domain protein TD69_05330 ENOG4105D7V transposase TD69_05345 ENOG4108IND Tetr family transcriptional regulator TD69_05350 ENOG4105EQ0 Major Facilitator superfamily TD69_05370 ENOG4108MUZ hydrolase TD69_05390 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator TD69_05405 ENOG4105C6V Glycerol-3-phosphate dehydrogenase TD69_05420 ENOG4105EMN RNA polymerase sigma factor TD69_05445 ENOG4105C57 major facilitator superfamily TD69_05450 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_05460 ENOG4105EEM helicase TD69_05465 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TD69_05495 ENOG4105K59 histidine triad (HIT) protein TD69_05525 ENOG410905X membrane-flanked domain protein TD69_05535 ENOG4105CKV Membrane TD69_05580 ENOG410905X membrane-flanked domain protein TD69_05585 ENOG4105CKV Membrane TD69_05590 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation TD69_05595 ENOG4105BZ4 penicillin-binding protein TD69_05600 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) TD69_05610 ENOG4105C1Q protoporphyrinogen oxidase TD69_05635 ENOG4105NA0 Transcriptional regulator TD69_05650 ENOG4105ECB domain protein TD69_05680 ENOG4106AXD TD69_05685 ENOG4108RQ5 Beta-lactamase domain-containing protein TD69_05690 ENOG4105DF9 Lipoate-protein, ligase TD69_05700 ENOG4105CEY Amp-dependent synthetase and ligase TD69_05730 ENOG4105CNA YD repeat protein TD69_05765 ENOG4105ENX hydrolase TD69_05775 ENOG4107RN3 metallophosphoesterase TD69_05780 ENOG4107TVP HD domain protein TD69_05790 ENOG4108AEY RNA polymerase sigma factor TD69_05795 ENOG41086D8 Transcriptional regulator TD69_05815 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_05840 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 TD69_05845 ENOG4105C8Q Methyl-accepting chemotaxis TD69_05865 ENOG4105ZU5 s-layer protein TD69_05870 ENOG4107QP3 malate synthase g TD69_05885 ENOG4105VEQ Cold shock protein TD69_05900 ENOG4105XVF Competence transcription factor TD69_05915 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination TD69_05920 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation TD69_05965 ENOG4105ERH Fumarylacetoacetate hydrolase TD69_05990 ENOG4105CAQ asparagine synthetase TD69_05995 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) TD69_06000 ENOG4105CH6 catalase TD69_06030 ENOG4105QNR S1 RNA binding domain protein TD69_06040 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TD69_06050 ENOG4107AYK membrAne TD69_06055 ENOG41073B9 TD69_06065 ENOG4108KP7 hydrolase TD69_06080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit TD69_06105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TD69_06110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) TD69_06125 ENOG4105C31 Tryptophanyl-tRNA synthetase TD69_06140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component TD69_06145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD69_06155 ENOG4108JQ7 (ABC) transporter TD69_06160 ENOG4105UQX Mate efflux family protein TD69_06185 ENOG4108ZCF integral membrane protein TD69_06195 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TD69_06205 ENOG4105DPN Oligoendopeptidase f TD69_06220 ENOG4108Z18 K06886 hemoglobin TD69_06225 ENOG4105MIX Adenylate cyclase TD69_06240 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) TD69_06245 ENOG4105EMS pseudouridine synthase TD69_06265 ENOG4105K64 Glycosyl transferase, family 2 TD69_06285 ENOG4107TVC Glycosyl transferase, family 2 TD69_06305 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) TD69_06310 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase TD69_06320 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase TD69_06370 ENOG4108WVJ 2'-5' rna ligase TD69_06395 ENOG4105CK7 Sodium proline symporter TD69_06405 ENOG4105CRQ synthase (Component I) TD69_06410 ENOG4105DDQ anthranilate synthase TD69_06500 ENOG4105C7S Dehydrogenase TD69_06510 ENOG4105VZ8 Transcriptional regulator TD69_06570 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) TD69_06580 ENOG4105DZ1 carboxypeptidase TD69_06585 ENOG4105VFR signal peptidase TD69_06620 ENOG4105C26 Dehydrogenase TD69_06625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TD69_06630 ENOG4105F38 ABC transporter, permease TD69_06635 ENOG4105D38 putrescine abc transporter TD69_06640 ENOG4107RUE extracellular solute-binding protein family 1 TD69_06650 ENOG4105EYF MMPL domain protein TD69_06660 ENOG4108YBP pseudouridine synthase TD69_06670 ENOG4105K4I Scp-like extracellular TD69_06675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) TD69_06680 ENOG4105CQB FAD linked oxidase domain protein TD69_06695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_06700 ENOG4105BZU Histidine kinase TD69_06705 ENOG4105JXH GntR family transcriptional regulator TD69_06725 ENOG4106A3R peptidase TD69_06735 ENOG4108QTI )-transporter TD69_06740 ENOG4107TS3 membrane protein, TerC TD69_06745 ENOG4105CZN Potassium uptake protein TD69_06750 ENOG410681C small acid-soluble spore protein TD69_06755 ENOG4108Z7G MaoC domain protein dehydratase TD69_06775 ENOG4105CHR reductase TD69_06785 ENOG4105MWK D-amino acid dehydrogenase, small subunit TD69_06805 ENOG4105C4Y ABC transporter TD69_06815 ENOG4107RCV ABC transporter, permease TD69_06820 ENOG4108KAZ Involved in phosphonate degradation (By similarity) TD69_06835 ENOG4105E98 transcriptional regulator DeoR family TD69_06860 ENOG4105PXI polysaccharide deacetylase TD69_06870 ENOG4105BZU Histidine kinase TD69_06875 ENOG41090MY MarR family Transcriptional regulator TD69_06885 ENOG4106DF1 TD69_06895 ENOG4105BZU Histidine kinase TD69_06905 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase TD69_06910 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) TD69_06955 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) TD69_06975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) TD69_06980 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family TD69_06985 ENOG4105CZV ABC transporter TD69_06995 ENOG4105CJ1 ABC, transporter TD69_07035 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A TD69_07040 ENOG4105EA8 2-Nitropropane dioxygenase TD69_07045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD TD69_07055 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein TD69_07080 ENOG4105NQC Flavodoxin TD69_07115 ENOG4107QMU Mate efflux family protein TD69_07120 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) TD69_07150 ENOG4105CZN Potassium uptake protein TD69_07155 ENOG41063Y9 TD69_07160 ENOG4105KBJ sporulation protein ytfj TD69_07190 ENOG4105CM2 brancheD-chain amino acid aminotransferase TD69_07195 ENOG4105C7K acetolactate synthase TD69_07200 ENOG4108ZP8 Acetolactate synthase small subunit TD69_07205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TD69_07215 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) TD69_07240 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) TD69_07275 ENOG4107RVV histidinol phosphate phosphatase, hisj family TD69_07290 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase TD69_07295 ENOG4105E0M Sulfatase TD69_07305 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) TD69_07325 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) TD69_07330 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) TD69_07340 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TD69_07345 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein TD69_07350 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein TD69_07360 ENOG4105C8J )-transporter TD69_07380 ENOG4105DFD Na H antiporter TD69_07400 ENOG4105ENE Histidine kinase TD69_07405 ENOG4105WH1 Two component transcriptional regulator luxr family TD69_07425 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) TD69_07450 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) TD69_07475 ENOG4105CJ3 phosphate transporter TD69_07480 ENOG4107GRR phosphate transport regulator TD69_07485 ENOG4105BZ4 penicillin-binding protein TD69_07500 ENOG4105BZU Histidine kinase TD69_07505 ENOG4105I3N Conserved Protein TD69_07520 ENOG4105BZU Histidine kinase TD69_07555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TD69_07560 ENOG4105DZ1 carboxypeptidase TD69_07565 ENOG4108JIC nucleoside recognition domain protein TD69_07575 ENOG4105FE9 pseudouridine synthase TD69_07585 ENOG4107TWT Cytochrome c biogenesis protein TD69_07590 ENOG4105CRE cytochrome C TD69_07595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_07600 ENOG4105BZU Histidine kinase TD69_07605 ENOG4108WBT adenosyltransferase TD69_07620 ENOG4108SAX Membrane TD69_07630 ENOG4105T7X TD69_07635 ENOG4105C9U ATP-dependent DNA helicase RecQ TD69_07640 ENOG4105I7S Abortive infection protein TD69_07655 ENOG4107X2D transcriptional regulator, merr family TD69_07660 ENOG4108S6Z Negative regulator of genetic competence TD69_07685 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase TD69_07690 ENOG4107RB3 L-asparaginase TD69_07725 ENOG4105S2F TD69_07730 ENOG41065D1 TD69_07760 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) TD69_07775 ENOG4105XXQ heptaprenyl diphosphate synthase component I TD69_07785 ENOG4105EAH synthase TD69_07805 ENOG4105CIH Imidazole acetol-phosphate transaminase TD69_07810 ENOG41068YB TPR repeat-containing protein TD69_07825 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) TD69_07830 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) TD69_07835 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit TD69_07865 ENOG4108JYZ YitT family TD69_07870 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase TD69_07885 ENOG4105FJR Lmbe family TD69_07890 ENOG4105CPK Glycosyl transferase (Group 1 TD69_07930 ENOG4105DVT helicase TD69_07935 ENOG4105YAC TD69_07955 ENOG4105CSM endonuclease III TD69_07965 ENOG4105BZ4 penicillin-binding protein TD69_08015 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) TD69_08025 ENOG4105DVT helicase TD69_08030 ENOG4105CTD carboxy-peptidase TD69_08045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) TD69_08055 ENOG4105C2W permease TD69_08060 ENOG4105DHF Membrane TD69_08065 ENOG410890F Dynamin family TD69_08075 ENOG4108W0I acetyltransferase TD69_08085 ENOG4105KHC sulfurtransferase TD69_08100 ENOG4106032 Glutathionylspermidine synthase TD69_08175 ENOG4108SZE gCN5-related N-acetyltransferase TD69_08195 ENOG41081VK Ribonuclease TD69_08260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD69_08270 ENOG4107RWR Sodium hydrogen exchanger TD69_08280 ENOG4108Z5V transcriptional regulator, merr family TD69_08290 ENOG4105H67 Protein of unknown function (DUF421) TD69_08295 ENOG41080C8 DUF218 domain TD69_08350 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) TD69_08360 ENOG4107R0U MotA TolQ exbB proton channel TD69_08365 ENOG4105ER2 Ompa motb domain protein TD69_08370 ENOG4107YTP response regulator receiver protein TD69_08380 ENOG4105DD5 Flagellar motor switch protein TD69_08395 ENOG4105BZU Histidine kinase TD69_08415 ENOG4105E1Q flagellar hook-associated protein TD69_08420 ENOG4105DTJ flagellar hook-associated protein TD69_08445 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) TD69_08450 ENOG4108ZC9 flagellar basal-body rod protein flgc TD69_08455 ENOG41075Z6 flagellar hook-basal body complex protein fliE TD69_08460 ENOG4107U2N Flagellar M-ring protein TD69_08470 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) TD69_08505 ENOG4105BZE flagellar hook protein, FlgE TD69_08530 ENOG4105K64 Glycosyl transferase, family 2 TD69_08560 ENOG4107TVC Glycosyl transferase, family 2 TD69_08585 ENOG4105I03 Flagellin TD69_08590 ENOG4105E4C Lytic transglycosylase catalytic TD69_08605 ENOG4105DD5 Flagellar motor switch protein TD69_08615 ENOG4105CN7 Flagellar biosynthetic protein FliP TD69_08620 ENOG4105VS8 Flagellar biosynthetic protein fliq TD69_08630 ENOG4105D00 flagellar biosynthetic protein flhB TD69_08635 ENOG4105D7B Flagellar biosynthesis protein flha TD69_08645 ENOG4105KTQ flagellar basal-body rod protein TD69_08650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TD69_08675 ENOG4108RZE Tetr family transcriptional regulator TD69_08695 ENOG4105KAC Antibiotic biosynthesis monooxygenase TD69_08720 ENOG4105DUM transcriptional regulator, lysR family TD69_08725 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) TD69_08730 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein TD69_08735 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component TD69_08740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) TD69_08775 ENOG4105CVJ phosphoglycerate mutase TD69_08805 ENOG4105CAQ asparagine synthetase TD69_08825 ENOG4105PGM cation diffusion facilitator family transporter TD69_08835 ENOG4105DRR Transcriptional regulator, GntR family TD69_08840 ENOG4108UZ3 Transporter TD69_08845 ENOG4105CKI cobalamin synthesis protein TD69_08850 ENOG4108PJD permease TD69_08865 ENOG4105DFD Na H antiporter TD69_08870 ENOG4105C9Q fumarate hydratase class II TD69_08900 ENOG4105EC3 peptidase S51, dipeptidase E TD69_08920 ENOG4107QIV Cytochrome c biogenesis protein TD69_08955 ENOG4106BRA Membrane TD69_08990 ENOG4105CJ1 ABC, transporter TD69_09010 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) TD69_09020 ENOG4108IJ0 Aspartate ammonia-lyase TD69_09025 ENOG4105C6K Malic enzyme TD69_09095 ENOG4105FVX TD69_09135 ENOG4105CSR polyphosphate kinase 2 TD69_09155 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) TD69_09170 ENOG4105EU0 Major facilitator Superfamily TD69_09175 ENOG4105C6T cysteine synthase TD69_09195 ENOG4105C8J )-transporter TD69_09205 ENOG4105X5K response regulator receiver protein TD69_09210 ENOG4105H67 Protein of unknown function (DUF421) TD69_09225 ENOG4106KE4 Dehydrogenase TD69_09240 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) TD69_09245 ENOG4105CHR reductase TD69_09250 ENOG4105CM2 brancheD-chain amino acid aminotransferase TD69_09255 ENOG4105C7K acetolactate synthase TD69_09260 ENOG4108ZP8 Acetolactate synthase small subunit TD69_09265 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase TD69_09275 ENOG4105C7B Threonine dehydratase TD69_09300 ENOG4105C6X Major Facilitator TD69_09305 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b TD69_09315 ENOG4105DY9 regulatoR TD69_09320 ENOG4105CYC Transferase TD69_09340 ENOG4105F6J Alpha beta hydrolase fold TD69_09345 ENOG4108J59 Extracellular solute-binding protein, family 5 TD69_09375 ENOG41068WN TD69_09395 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) TD69_09400 ENOG4105C72 UPF0176 protein TD69_09410 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) TD69_09445 ENOG4107RHR regulatoR TD69_09455 ENOG4105D9N nucleoside TD69_09460 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) TD69_09495 ENOG4107RAQ aminopeptidase TD69_09500 ENOG4107STQ Multicopper oxidase TD69_09545 ENOG4108T5E Copper resistance protein TD69_09550 ENOG4105KTB nuclear export factor GLE1 TD69_09560 ENOG4107RT3 EamA-like transporter family TD69_09565 ENOG4105GZI Transcriptional regulator TD69_09570 ENOG4108Z40 Transcriptional regulator TD69_09575 ENOG4107ZXU DSBA oxidoreductase TD69_09580 ENOG4108TVJ Nitroreductase TD69_09590 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TD69_09595 ENOG4106F5Q Membrane TD69_09600 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TD69_09610 ENOG4105CKI cobalamin synthesis protein TD69_09630 ENOG4108Z7G MaoC domain protein dehydratase TD69_09635 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TD69_09645 ENOG4105C0Z ABC transporter TD69_09650 ENOG4108IV0 ABC, transporter TD69_09655 ENOG4105C32 Amino acid ABC transporter (Permease) TD69_09665 ENOG4105SKE transcriptional Regulator LysR family TD69_09685 ENOG4105YGB Transcriptional regulator TD69_09695 ENOG4105C4M (Ubiquinol oxidase) subunit I TD69_09700 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TD69_09705 ENOG4108JJ9 ABC, transporter TD69_09710 ENOG4108JJ8 (ABC) transporter TD69_09755 ENOG4105BZ1 (ABC) transporter TD69_09760 ENOG4105BZ1 (ABC) transporter TD69_09765 ENOG4105EFI regulatoR TD69_09770 ENOG4105BZU Histidine kinase TD69_09790 ENOG41075D4 Aminoglycoside 6-adenylyltransferase TD69_09795 ENOG4108ZJ4 polysaccharide deacetylase TD69_09815 ENOG4105D6E homoserine dehydrogenase TD69_09840 ENOG4108KGH TRANSCRIPTIONal TD69_09850 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_09855 ENOG4105BZU Histidine kinase TD69_09860 ENOG4107VMI polysaccharide deacetylase TD69_09870 ENOG4105KT7 mgtC SapB transporter TD69_09875 ENOG4105VRR gCN5-related N-acetyltransferase TD69_09885 ENOG4105DUU IucA IucC family protein TD69_09890 ENOG4105CEY Amp-dependent synthetase and ligase TD69_09905 ENOG4108WBH protein TIM barrel TD69_09910 ENOG4105YWU small acid-soluble spore protein TD69_09920 ENOG4108ZUB Lysine exporter protein (Lyse ygga) TD69_09970 ENOG4105KRN Transcriptional regulator, abrb family TD69_09980 ENOG4105YVS arsR family transcriptional regulator TD69_09985 ENOG4107SET aldo keto reductase TD69_09990 ENOG4107XZQ multidrug resistance protein TD69_10015 ENOG4105C8Q Methyl-accepting chemotaxis TD69_10035 ENOG4108K88 Membrane TD69_10040 ENOG4108WPJ Ferritin-like domain TD69_10055 ENOG4105DEN Luciferase family TD69_10075 ENOG4107QM2 Aldo Keto reductase TD69_10080 ENOG4105CKI cobalamin synthesis protein TD69_10150 ENOG4105DSE periplasmic solute binding protein TD69_10160 ENOG4105K4T epimerase TD69_10170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TD69_10195 ENOG4105CVJ phosphoglycerate mutase TD69_10215 ENOG4107T5V SNARE associated Golgi TD69_10230 ENOG4108PJD permease TD69_10240 ENOG4108S4H thioesterase Superfamily protein TD69_10245 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) TD69_10265 ENOG4105SXS Protein of unknown function (DUF456) TD69_10270 ENOG4105C37 (CBS) domain TD69_10290 ENOG4108Z7R Chaperone CsaA TD69_10310 ENOG4108ZRV stage ii sporulation protein p TD69_10320 ENOG4108VXD carboxy-peptidase TD69_10330 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) TD69_10355 ENOG4108X4Q Hydrolase TD69_10365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) TD69_10370 ENOG4107RBS Methyltransferase TD69_10385 ENOG41087PP glycosyltransferase MGT family TD69_10390 ENOG4108JYZ YitT family TD69_10395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family TD69_10420 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) TD69_10470 ENOG4105KBJ sporulation protein ytfj TD69_10495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) TD69_10515 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) TD69_10520 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_10530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein TD69_10535 ENOG4105EMN RNA polymerase sigma factor TD69_10560 ENOG4108V06 Glutathione peroxidase TD69_10575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TD69_10595 ENOG4108IUE nitrate reductase beta subunit TD69_10600 ENOG4105R3A Nitrate reductase TD69_10625 ENOG4107V6Q Cyclic nucleotide-binding domain TD69_10630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) TD69_10635 ENOG4105D06 uba thif-type nad fad binding protein TD69_10640 ENOG4105CVM Molybdenum cofactor synthesis domain protein TD69_10645 ENOG4108ZAF Molybdopterin TD69_10670 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein TD69_10675 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein TD69_10680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) TD69_10685 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit TD69_10690 ENOG4108IFG nitrite reductase, (NAD(P)H) TD69_10695 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) TD69_10730 ENOG4105MCT stage V sporulation protein S TD69_10745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase TD69_10765 ENOG4105C5H ABC transporter TD69_10780 ENOG4108UUM single-stranded DNA-binding protein TD69_10795 ENOG41061H0 Monooxygenase TD69_10815 ENOG4107YX5 Pfam:DUF548 TD69_10820 ENOG4105C75 arginyL-tRNA synthetase TD69_10845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TD69_10860 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) TD69_10865 ENOG4105C5S asparaginyl-tRNA synthetase TD69_10885 ENOG4105EC2 ftsk spoIIIe TD69_10980 ENOG4105BZW Glycerate kinase TD69_10985 ENOG4107QPK )-transporter TD69_10990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_10995 ENOG41062D9 Histidine kinase TD69_11010 ENOG4105C8J )-transporter TD69_11030 ENOG4107XGZ Hydrolase TD69_11035 ENOG4105CY2 Citrate transporter TD69_11040 ENOG4105C0A alcohol dehydrogenase TD69_11055 ENOG4105KD7 acetyltransferase TD69_11085 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 TD69_11105 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) TD69_11120 ENOG4107RVG penicillin-binding protein TD69_11125 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) TD69_11130 ENOG4105E9Q Acyl-transferase TD69_11135 ENOG4108UT2 hemolysin iii TD69_11145 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) TD69_11155 ENOG4108RCR degv family TD69_11160 ENOG4105E8R UPF0173 metal-dependent hydrolase TD69_11165 ENOG4108KF3 Electron transport protein SCO1 SenC TD69_11170 ENOG4107Y70 Heat shock protein TD69_11175 ENOG4105CAQ asparagine synthetase TD69_11195 ENOG4108MES Periplasmic binding protein TD69_11200 ENOG4105F0I Aminotransferase TD69_11235 ENOG4105D8X mechanosensitive ion channel TD69_11240 ENOG4105BZU Histidine kinase TD69_11245 ENOG4105WH1 Two component transcriptional regulator luxr family TD69_11255 ENOG4106KNT transcriptional regulator TD69_11290 ENOG4105CMG Carbohydrate kinase TD69_11295 ENOG4105CMG Carbohydrate kinase TD69_11325 ENOG4108IJ8 ABC transporter TD69_11330 ENOG4105E90 ABC transporter TD69_11365 ENOG4105C37 (CBS) domain TD69_11390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD69_11405 ENOG4107S4Y M20 DapE family protein YgeY TD69_11410 ENOG4108TSC N-acetyltransferase TD69_11415 ENOG4108JUB Transcriptional regulator TD69_11420 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein TD69_11460 ENOG4108N23 SpoOM-related protein TD69_11465 ENOG410841Q phosphoesterase PA-phosphatase related protein TD69_11475 ENOG4105SZ6 Thioredoxin TD69_11490 ENOG4108IBT Inherit from COG: transposase TD69_11595 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) TD69_11635 ENOG4105BZ4 penicillin-binding protein TD69_11640 ENOG4105CZM Major Facilitator TD69_11645 ENOG4105W8X HesB YadR YfhF-family protein TD69_11655 ENOG4105DXD 2-methylcitrate dehydratase TD69_11660 ENOG4105CR4 methylisocitrate lyase TD69_11665 ENOG4105C1G acyl-Coa dehydrogenase TD69_11670 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase TD69_11680 ENOG4105N14 lysine exporter protein LysE YggA TD69_11685 ENOG4105E39 Enoyl-CoA hydratase TD69_11700 ENOG4107RFY SbcCD D subunit TD69_11705 ENOG4105EYH Exonuclease TD69_11735 ENOG4105FCD Major Facilitator TD69_11740 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase TD69_11745 ENOG4105E4F Isochorismate synthase TD69_11750 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase TD69_11755 ENOG4105WQI isochorismatase TD69_11760 ENOG4105CEY Amp-dependent synthetase and ligase TD69_11765 ENOG4105WQT MbtH domain protein TD69_11770 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_11785 ENOG4105K70 DNA-binding protein TD69_11805 ENOG4105BZG amino acid carrier protein TD69_11830 ENOG4105FE9 pseudouridine synthase TD69_11835 ENOG4105C22 threonyL-tRNA synthetase TD69_11850 ENOG4107SKW Inherit from COG: Alpha beta hydrolase TD69_11875 ENOG4108D32 Methyltransferase TD69_11905 ENOG41081I9 integral membrane protein TD69_11920 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TD69_11930 ENOG4105EYF MMPL domain protein TD69_11955 ENOG4105WCN acetyltransferase TD69_11985 ENOG4105C1Q protoporphyrinogen oxidase TD69_11995 ENOG41068WN TD69_12005 ENOG4105VEQ Cold shock protein TD69_12025 ENOG410667J hydrolase TD69_12070 ENOG4107V2S Transcriptional regulator TD69_12075 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TD69_12090 ENOG4105DND Transcriptional regulator TD69_12095 ENOG4108RPX mosc domain containing protein TD69_12110 ENOG4105BZ1 (ABC) transporter TD69_12115 ENOG4105BZ1 (ABC) transporter TD69_12135 ENOG4108JCI Transcriptional regulator TD69_12165 ENOG4108KPJ rna polymerase sigma factor TD69_12225 ENOG4107STF Involved in phosphonate degradation (By similarity) TD69_12245 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) TD69_12260 ENOG4105C1J atp-dependent rna helicase TD69_12275 ENOG4108RZE Tetr family transcriptional regulator TD69_12295 ENOG41088CC tellurite resistance protein tehB TD69_12305 ENOG4108I0C methyltransferase TD69_12310 ENOG4107RA9 decarboxylase TD69_12315 ENOG41090HR transcriptional regulator TD69_12355 ENOG4105CIN aminoacyl-histidine dipeptidase TD69_12380 ENOG4107RF6 penicillin-binding protein TD69_12395 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase TD69_12400 ENOG4105ETE Transcriptional regulator (LacI family TD69_12405 ENOG4105IE8 Alpha-ketoglutarate permease TD69_12410 ENOG4105CK5 oxidoreductase TD69_12435 ENOG4105D2N Aldolase TD69_12440 ENOG4105DH8 myo-inositol catabolism TD69_12455 ENOG4105CGH 5'-nucleotidase TD69_12475 ENOG4105VZ8 Transcriptional regulator TD69_12490 ENOG4108VXD carboxy-peptidase TD69_12510 ENOG41067SE Tetr family transcriptional regulator TD69_12515 ENOG4105C5H ABC transporter TD69_12525 ENOG4105BZU Histidine kinase TD69_12535 ENOG4106ANW SMI1_KNR4 TD69_12540 ENOG4105CEP NADH dehydrogenase TD69_12545 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) TD69_12560 ENOG4105CJ1 ABC, transporter TD69_12570 ENOG4107Z3H Transcriptional regulator, TetR family TD69_12585 ENOG4105C1G acyl-Coa dehydrogenase TD69_12590 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TD69_12595 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit TD69_12600 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase TD69_12605 ENOG4105E39 Enoyl-CoA hydratase TD69_12610 ENOG4107QX3 carboxylase TD69_12615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TD69_12625 ENOG4105WCN acetyltransferase TD69_12630 ENOG4105DBI uridine monophosphokinase TD69_12645 ENOG4105DZ1 carboxypeptidase TD69_12660 ENOG4105T9C HD domain TD69_12670 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) TD69_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TD69_12710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TD69_12725 ENOG4105FQP Beta-lactamase TD69_12735 ENOG4107Y80 Major Facilitator superfamily TD69_12755 ENOG4105CUV Homoserine Kinase TD69_12790 ENOG4105CPQ Dehydrogenase TD69_12805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TD69_12810 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TD69_12905 ENOG4105ETU transcriptional activator (TenA TD69_13015 ENOG410667J hydrolase TD69_13025 ENOG4105BZU Histidine kinase TD69_13030 ENOG4107RF6 penicillin-binding protein TD69_13050 ENOG4108JJB ABC transporter TD69_13060 ENOG4108HGU Histidine kinase TD69_13075 ENOG4105CB2 alcohol dehydrogenase TD69_13080 ENOG4105CJN penicillin-binding protein TD69_13090 ENOG4105FQP Beta-lactamase TD69_13125 ENOG4108V4B ThiJ pfpI TD69_13155 ENOG4107Y80 Major Facilitator superfamily TD69_13170 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TD69_13190 ENOG4107Y9U Membrane TD69_13225 ENOG4105FCD Major Facilitator TD69_13240 ENOG4105E09 nadh pyrophosphatase TD69_13245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) TD69_13250 ENOG4108Z4K mutator MutT protein TD69_13285 ENOG4108XI2 Domain of unknown function (DUF1963) TD69_13315 ENOG4108NRW Phospholipase, patatin family TD69_13320 ENOG4105KWG Pfam:DUF1696 TD69_13355 ENOG4105PKS Excinuclease abc c subunit domain protein TD69_13395 ENOG4107VFR oxidoreductase TD69_13420 ENOG4105PAD Hydrolase TD69_13440 ENOG4105DY8 decarboxylase TD69_13455 ENOG4108IUM Glycogen debranching enzyme TD69_13480 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) TD69_13490 ENOG4105FDR Membrane TD69_13525 ENOG4108V3A UPF0421 protein TD69_13545 ENOG4105MSI germination protein ypeb TD69_13565 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) TD69_13570 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) TD69_13575 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) TD69_13580 ENOG4107Z3H Transcriptional regulator, TetR family TD69_13610 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family TD69_13630 ENOG4105E98 transcriptional regulator DeoR family TD69_13650 ENOG41062ES Transcriptional regulator TD69_13670 ENOG4107QKR Dehydrogenase TD69_13680 ENOG4107RUY (E1 component), alpha subunit TD69_13690 ENOG4105E1F short-chain dehydrogenase reductase TD69_13695 ENOG4105RHY Pfam:UPF0157 TD69_13730 ENOG4107SQ8 Glycine betaine TD69_13735 ENOG4108IJ7 Glycine betaine TD69_13760 ENOG4105E66 phosphoriboisomerase A TD69_13765 ENOG41082BV acetyltransferase TD69_13770 ENOG4108M1A Chitin-binding protein TD69_13815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 TD69_13865 ENOG4105EEM helicase TD69_13885 ENOG4105C9U ATP-dependent DNA helicase RecQ TD69_13940 ENOG4108M1A Chitin-binding protein TD69_13955 ENOG4105BZG amino acid carrier protein TD69_13960 ENOG4105C26 Dehydrogenase TD69_13965 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TD69_13970 ENOG4105CTU Proline racemase TD69_13975 ENOG4105CTU Proline racemase TD69_13980 ENOG41080HI glycine oxidase TD69_14020 ENOG4107T5V SNARE associated Golgi TD69_14035 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD TD69_14040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) TD69_14055 ENOG4105DTQ mandelate racemase muconate lactonizing TD69_14095 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) TD69_14100 ENOG4105BZU Histidine kinase TD69_14105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_14145 ENOG4105EPR degv family TD69_14185 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) TD69_14190 ENOG4106K7D Major facilitator family transporter TD69_14210 ENOG4107BMA Transglycosylase associated protein TD69_14225 ENOG41089UC methyltransferase, type 11 TD69_14260 ENOG4105CHM Aminotransferase TD69_14295 ENOG4105DVE abc transporter atp-binding protein TD69_14345 ENOG4105C02 permease TD69_14360 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) TD69_14365 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component TD69_14370 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein TD69_14395 ENOG4105E09 nadh pyrophosphatase TD69_14415 ENOG4108AQF aminoglycoside N(3)-acetyltransferase TD69_14465 ENOG4107VC0 DNA alkylation repair enzyme TD69_14475 ENOG4107VMI polysaccharide deacetylase TD69_14485 ENOG4108ZCF integral membrane protein TD69_14490 ENOG4105E0M Sulfatase TD69_14495 ENOG4105C5H ABC transporter TD69_14505 ENOG4105EYF MMPL domain protein TD69_14510 ENOG4105EYF MMPL domain protein TD69_14515 ENOG4105EYF MMPL domain protein TD69_14520 ENOG41082JN Transcriptional regulator TD69_14540 ENOG4105CIH Imidazole acetol-phosphate transaminase TD69_14545 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase TD69_14550 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase TD69_14585 ENOG41069ER domain protein TD69_14595 ENOG4105EMN RNA polymerase sigma factor TD69_14620 ENOG4105D4B ABC, transporter TD69_14630 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane TD69_14640 ENOG4105DKT Transcriptional regulator TD69_14655 ENOG41061GT Aldolase TD69_14675 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) TD69_14705 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) TD69_14710 ENOG4105II7 pyrroline-5-carboxylate reductase TD69_14720 ENOG4107258 Transcriptional regulator TD69_14730 ENOG4105E0Y RtcB Protein TD69_14735 ENOG4105ECK Fatty Acid Desaturase TD69_14740 ENOG4105G6Z alkaline phosphatase TD69_14750 ENOG4105VMP Transcriptional regulator TD69_14765 ENOG41090T1 Membrane TD69_14775 ENOG4108WCX response regulator TD69_14785 ENOG41068WN TD69_14810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TD69_14835 ENOG4105CKK Glycosyl transferase, family 2 TD69_14860 ENOG4105CKK Glycosyl transferase, family 2 TD69_14870 ENOG4105C8Y Acetylornithine aminotransferase TD69_14910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 TD69_14920 ENOG4108TVJ Nitroreductase TD69_14925 ENOG4105FS7 Transcriptional regulator TD69_14960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TD69_14970 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) TD69_15000 ENOG4108XET gCN5-related N-acetyltransferase TD69_15080 ENOG410635A Membrane TD69_15085 ENOG4105KNA -acetyltransferase TD69_15090 ENOG4108IQI permease TD69_15100 ENOG4105F1N DNA alkylation repair TD69_15150 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) TD69_15190 ENOG4105P4J Allophanate hydrolase, subunit 1 TD69_15195 ENOG4107258 Transcriptional regulator TD69_15205 ENOG4106N3A copper homeostasis protein cutc TD69_15210 ENOG4108ZRV stage ii sporulation protein p TD69_15215 ENOG4108ZHR arsR family transcriptional regulator TD69_15225 ENOG4105FDT acyl-CoA dehydrogenase TD69_15245 ENOG4105DWD nucleoside recognition domain protein TD69_15275 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) TD69_15340 ENOG4105E2A Dehydrogenase TD69_15355 ENOG4108IJ0 Aspartate ammonia-lyase TD69_15360 ENOG4105HDK L-asparaginase TD69_15365 ENOG4108IMY Transcriptional regulator TD69_15375 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) TD69_15380 ENOG4105CUB amino acid TD69_15390 ENOG4105II7 pyrroline-5-carboxylate reductase TD69_15400 ENOG4105C6K Malic enzyme TD69_15410 ENOG4108NHD germination protein TD69_15415 ENOG4108NHD germination protein TD69_15440 ENOG4105CSV Glutaminase TD69_15470 ENOG4105CGH 5'-nucleotidase TD69_15475 ENOG4105CH6 catalase TD69_15485 ENOG4105CHJ isochorismatase hydrolase TD69_15550 ENOG4108606 TspO/MBR family TD69_15555 ENOG4105CVP deoxyribo-dipyrimidine photolyase TD69_15570 ENOG4108TWJ NADH dehydrogenase subunit 5 TD69_15575 ENOG4105GPN Uncharacterized conserved protein (DUF2294) TD69_15585 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase TD69_15590 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) TD69_15595 ENOG4105DSE periplasmic solute binding protein TD69_15600 ENOG4105CC5 ABC transporter TD69_15605 ENOG4105DIK (ABC) transporter TD69_15635 ENOG4105D6J arsenicaL-resistance protein TD69_15640 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_15645 ENOG41085FC arsR family transcriptional regulator TD69_15660 ENOG4105F7F Chaperone TD69_15670 ENOG4105CHR reductase TD69_15675 ENOG4108YXU transcriptional regulator AsnC family TD69_15750 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) TD69_15760 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_15770 ENOG4105IIP Membrane TD69_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_15790 ENOG41062D9 Histidine kinase TD69_15820 ENOG4105K6H D-cysteine desulfhydrase TD69_15845 ENOG4105VZ8 Transcriptional regulator TD69_15860 ENOG4108NNI Beta-lactamase domain-containing protein TD69_15865 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase TD69_15875 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) TD69_15880 ENOG4105JQZ Methyltransferase TD69_15895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TD69_15900 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) TD69_15920 ENOG4105BZU Histidine kinase TD69_15935 ENOG4108U05 Transcriptional regulator TD69_15950 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) TD69_15955 ENOG4105DJB Major Facilitator Superfamily TD69_15960 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) TD69_15965 ENOG4107QR9 Iron-sulfur cluster binding protein TD69_15975 ENOG4106P55 Transcriptional regulator TD69_15985 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A TD69_16025 ENOG4105TRI Hydrolase TD69_16060 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD69_16090 ENOG4107QJQ Mate efflux family protein TD69_16105 ENOG4105EQ0 Major Facilitator superfamily TD69_16110 ENOG4108JGH Tetr family transcriptional regulator TD69_16125 ENOG4105C44 Serine transporter TD69_16130 ENOG4105EJQ L-serine dehydratase TD69_16145 ENOG4108JPW Aminotransferase TD69_16160 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) TD69_16170 ENOG4105DVH amino acid TD69_16185 ENOG4108JQ1 Dehydrogenase TD69_16205 ENOG4108AEY RNA polymerase sigma factor TD69_16220 ENOG41082W1 Cupin 2, conserved barrel domain protein TD69_16230 ENOG410874W AraC family transcriptional regulator TD69_16245 ENOG4105HIR S-layer domain protein TD69_16285 ENOG4108ISG Major Facilitator TD69_16295 ENOG4107MII Sugar-specific transcriptional regulator TrmB TD69_16300 ENOG4105CZM Major Facilitator TD69_16320 ENOG4105DA5 (ABC) transporter TD69_16325 ENOG41069JR TD69_16335 ENOG4105RXJ TD69_16340 ENOG4105KPY Small multidrug resistance protein TD69_16345 ENOG4105KBX Transcriptional regulator, TetR family TD69_16360 ENOG4105CRW Short chain fatty acid transporter TD69_16370 ENOG4105DYS nad(p)h dehydrogenase (quinone) TD69_16400 ENOG4108JJB ABC transporter TD69_16405 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) TD69_16430 ENOG4108K8S endonuclease I TD69_16445 ENOG41067QW Transcriptional regulator TD69_16455 ENOG4108Z66 YbaK ebsC protein TD69_16460 ENOG4105CUT histidyl-tRNA synthetase TD69_16475 ENOG4105KVH Transcriptional regulator TD69_16480 ENOG4108RCM Nitroreductase TD69_16500 ENOG4108PSK reductase TD69_16510 ENOG4105CJ1 ABC, transporter TD69_16570 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_16575 ENOG4105DKQ ROK family TD69_16580 ENOG4106UW1 Major Facilitator superfamily TD69_16585 ENOG4108UW5 maltose o-acetyltransferase TD69_16600 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) TD69_16605 ENOG4105C31 Tryptophanyl-tRNA synthetase TD69_16610 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TD69_16635 ENOG4105DMQ Methyltransferase TD69_16645 ENOG4105EV4 Multidrug resistance protein mdtH TD69_16675 ENOG4105C37 (CBS) domain TD69_16690 ENOG4105DDN Pentapeptide repeat-containing protein TD69_16695 ENOG4105XDF Protein of unknown function (DUF1272) TD69_16700 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) TD69_16705 ENOG4105CMG Carbohydrate kinase TD69_16710 ENOG4105C6Z Gluconate TD69_16715 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) TD69_16730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase TD69_16735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase TD69_16740 ENOG4105CIS alcohol dehydrogenase TD69_16745 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone TD69_16765 ENOG4105EWI Short-chain dehydrogenase reductase Sdr TD69_16770 ENOG4105D4Y metalloprotease TD69_16790 ENOG4105CV8 reductase TD69_16795 ENOG4105F27 Major Facilitator TD69_16810 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) TD69_16815 ENOG4105C44 Serine transporter TD69_16850 ENOG4105KVH Transcriptional regulator TD69_16855 ENOG4108TZY GntR Family Transcriptional Regulator TD69_16865 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase TD69_16870 ENOG4105KVH Transcriptional regulator TD69_16875 ENOG4105KVH Transcriptional regulator TD69_16910 ENOG4105JAB phenazine biosynthesis protein, phzf family TD69_16920 ENOG4105CHR reductase TD69_16940 ENOG4105KVH Transcriptional regulator TD69_17010 ENOG4105KAF membrAne TD69_17035 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) TD69_17050 ENOG4107YXZ hydrolase, family 25 TD69_17075 ENOG4105ED2 Beta-lactamase TD69_17085 ENOG4105H3G oxidoreductase TD69_17160 ENOG4108TN2 lmbE family TD69_17170 ENOG4107R3E Citrate transporter TD69_17190 ENOG4108MES Periplasmic binding protein TD69_17200 ENOG4105EHG Permease protein TD69_17205 ENOG4105DQ5 transport system permease protein TD69_17210 ENOG4105NX3 Membrane TD69_17215 ENOG4107ZY0 Phenazine biosynthesis-like protein TD69_17235 ENOG4107CUJ Protein of unknown function (DUF2690) TD69_17245 ENOG4107V2S Transcriptional regulator TD69_17265 ENOG4105C98 muts2 protein TD69_17275 ENOG4105E5K Alpha-amylase TD69_17280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase TD69_17285 ENOG4105DPN Oligoendopeptidase f TD69_17290 ENOG4108A04 Beta-lactamase TD69_17320 ENOG4107VXM glycerophosphoryl diester phosphodiesterase TD69_17345 ENOG41082BM Transcriptional regulator, arsr family TD69_17350 ENOG4105CIS alcohol dehydrogenase TD69_17375 ENOG4105RHY Pfam:UPF0157 TD69_17385 ENOG4105C09 Bile acid TD69_17390 ENOG4105CQB FAD linked oxidase domain protein TD69_17415 ENOG4108UT6 Transferase hexapeptide repeat containing protein TD69_17425 ENOG4105K64 Glycosyl transferase, family 2 TD69_17430 ENOG4105E39 Enoyl-CoA hydratase TD69_17440 ENOG4105KT7 mgtC SapB transporter TD69_17450 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_17455 ENOG41073R8 VanW family TD69_17465 ENOG4108R1P TD69_17485 ENOG4105VEQ Cold shock protein TD69_17505 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) TD69_17525 ENOG410904N short-chain dehydrogenase reductase TD69_17535 ENOG4106IQC argininosuccinate lyase TD69_17550 ENOG4108IA2 Sodium pantothenate symporter TD69_17560 ENOG4105C26 Dehydrogenase TD69_17565 ENOG4105CHR reductase TD69_17575 ENOG4105EWU Squalene--hopene cyclase TD69_17585 ENOG4105FR1 rard protein TD69_17590 ENOG410696E Membrane TD69_17605 ENOG4105D1F ATP-binding protein TD69_17615 ENOG4108ZAF Molybdopterin TD69_17620 ENOG4105CVM Molybdenum cofactor synthesis domain protein TD69_17625 ENOG4105D06 uba thif-type nad fad binding protein TD69_17630 ENOG4105TMB Formate nitrite transporter TD69_17640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) TD69_17645 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) TD69_17655 ENOG4108JB9 formate dehydrogenase TD69_17665 ENOG4105E1K spore germination protein TD69_17730 ENOG4108KGH TRANSCRIPTIONal TD69_17740 ENOG4105EMN RNA polymerase sigma factor TD69_17765 ENOG4105CIG ABC transporter TD69_17775 ENOG4105D9R oxidoreductase TD69_17785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) TD69_17795 ENOG4105K4P CoA-binding domain protein TD69_17800 ENOG4105C0H protease TD69_17805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_17815 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase TD69_17820 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) TD69_17825 ENOG4105W8X HesB YadR YfhF-family protein TD69_17855 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TD69_17860 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen TD69_17870 ENOG4108JJA ABC, transporter TD69_17875 ENOG4108I0Z Aconitate hydratase TD69_17905 ENOG4105E5W Transporter TD69_17915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TD69_17935 ENOG4107F3J Amp-dependent synthetase and ligase TD69_17940 ENOG4107ZYJ bioY protein TD69_17945 ENOG4105CEY Amp-dependent synthetase and ligase TD69_17990 ENOG4107AYK membrAne TD69_18000 ENOG4105BZU Histidine kinase TD69_18005 ENOG4105FBA Phospholipase Carboxylesterase TD69_18010 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase TD69_18015 ENOG4105CK7 Sodium proline symporter TD69_18020 ENOG4105CBC glutamate synthase TD69_18025 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase TD69_18030 ENOG4108VJ1 Transcriptional regulator (CarD family TD69_18035 ENOG4108903 Formimidoylglutamase TD69_18060 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) TD69_18120 ENOG4107QIV Cytochrome c biogenesis protein TD69_18130 ENOG4107RSM transcriptional regulator TD69_18135 ENOG4105VAW lrga family TD69_18140 ENOG41067MG lrgb family TD69_18165 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase TD69_18180 ENOG4105BZ1 (ABC) transporter TD69_18185 ENOG4105BZ1 (ABC) transporter TD69_18205 ENOG4105D7V transposase TD69_18225 ENOG4105D5T phosphonate abc transporter TD69_18240 ENOG4105CGH 5'-nucleotidase TD69_18250 ENOG4108SVB resolvase TD69_18270 ENOG4105K7K Transcriptional regulator TD69_18305 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase TD69_18310 ENOG4105XSJ toxin secretion phage lysis holin TD69_18515 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) TD69_18620 ENOG4105C5F glutamine synthetase TD69_18625 ENOG4105KV4 Transcriptional regulator TD69_18630 ENOG4105CXI aluminum resistance protein TD69_18640 ENOG4105EN6 Membrane TD69_18645 ENOG4106F1P AAA ATPase, central domain protein TD69_18675 ENOG41069ER domain protein TD69_18680 ENOG4105DM4 PTS System TD69_18685 ENOG4105DE4 1-phosphofructokinase TD69_18690 ENOG4105E98 transcriptional regulator DeoR family TD69_18700 ENOG4108SJC Membrane TD69_18715 ENOG4105C85 amino acid TD69_18730 ENOG4105TMB Formate nitrite transporter TD69_18735 ENOG4105K70 DNA-binding protein TD69_18740 ENOG4105C59 p-type ATPase TD69_18745 ENOG410681U heavy metal transport detoxification protein TD69_18750 ENOG4105VPX protein, conserved in bacteria TD69_18760 ENOG4105NIV Esterase TD69_18765 ENOG4105E0A ABC, transporter TD69_18790 ENOG4105CGK Exodeoxyribonuclease III TD69_18800 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) TD69_18805 ENOG4105D03 DNA-3-methyladenine glycosylase II TD69_18835 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_18840 ENOG4105BZU Histidine kinase TD69_18860 ENOG41067MG lrgb family TD69_18875 ENOG4107TTQ Alpha beta hydrolase fold TD69_18880 ENOG4107YEI lmbE family TD69_18900 ENOG4105F0V Cell wall hydrolase TD69_18905 ENOG4107R6R udp-galactopyranose mutase TD69_18910 ENOG4105E0M Sulfatase TD69_18915 ENOG410890F Dynamin family TD69_18925 ENOG4107QHE Choloylglycine hydrolase TD69_18950 ENOG4105DA5 (ABC) transporter TD69_18975 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TD69_18980 ENOG4105DQU oxidoreductase, subunit beta TD69_18985 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein TD69_18990 ENOG4108IGT Dipeptidase TD69_18995 ENOG4105MCT stage V sporulation protein S TD69_19000 ENOG4105D48 metallophosphoesterase TD69_19025 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase TD69_19040 ENOG4105XZV Protein of unknown function (DUF3243) TD69_19045 ENOG4108RKS Short-chain dehydrogenase reductase Sdr TD69_19065 ENOG4105UIB (ABC) transporter TD69_19070 ENOG4105UIB (ABC) transporter TD69_19075 ENOG4108JQ9 ABC transporter TD69_19080 ENOG4105DIH basic membrane TD69_19085 ENOG4105FDP GntR family transcriptional regulator TD69_19090 ENOG4107QZI cell division protein FtsK TD69_19100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit TD69_19115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) TD69_19125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) TD69_19130 ENOG4108S0H Dipicolinic acid synthetase, b subunit TD69_19135 ENOG4105E35 Dipicolinate synthase subunit A TD69_19145 ENOG4105C1V Peptidase, M16 TD69_19165 ENOG4105DTN riboflavin biosynthesis protein ribF TD69_19170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) TD69_19180 ENOG4105W7A Protein of unknown function (DUF503) TD69_19190 ENOG4105VHM ribosomal protein TD69_19195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination TD69_19200 ENOG4105CHV Transcription elongation factor NusA TD69_19210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) TD69_19220 ENOG4105DZP Membrane-associated zinc metalloprotease TD69_19225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) TD69_19230 ENOG4105KNE Phosphatidate cytidylyltransferase TD69_19235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) TD69_19275 ENOG4108HE4 integrase family TD69_19285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TD69_19295 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha TD69_19310 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) TD69_19335 ENOG4105VB6 UPF0109 protein TD69_19355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) TD69_19360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) TD69_19375 ENOG4105CHR reductase TD69_19380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase TD69_19395 ENOG4105CB5 ATP-dependent DNA helicase recG TD69_19400 ENOG4105DP4 dak2 domain fusion protein ylov TD69_19405 ENOG4108ZAA Alkaline-shock protein TD69_19420 ENOG4105FJ0 thiamine TD69_19425 ENOG4105DJV ribulose-phosphate 3-epimerase TD69_19430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) TD69_19435 ENOG4105D9P serine threonine protein kinase TD69_19440 ENOG4108ZF3 Phosphatase TD69_19450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B TD69_19460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TD69_19465 ENOG4105C25 Primosomal protein n' TD69_19470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase TD69_19490 ENOG4105DSJ YicC domain protein TD69_19500 ENOG4105F23 Fibronectin-binding protein TD69_19505 ENOG4105DC7 peptidase M24 TD69_19560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain TD69_19585 ENOG4105C34 Pseudouridine synthase TD69_19600 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) TD69_19610 ENOG4105DBK s4 domain protein TD69_19615 ENOG41067XK integral membrane protein TD69_19625 ENOG4105DFA alanine racemase domain protein TD69_19630 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase TD69_19635 ENOG4105WR5 sporulation protein, YlmC YmxH family TD69_19645 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_19655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) TD69_19660 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) TD69_19665 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) TD69_19670 ENOG4105D4A Cell wall formation (By similarity) TD69_19675 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TD69_19680 ENOG4105CNI cell division protein FtsW TD69_19695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) TD69_19700 ENOG4105CJN penicillin-binding protein TD69_19705 ENOG4105CJN penicillin-binding protein TD69_19710 ENOG41068DC Essential cell division protein (By similarity) TD69_19745 ENOG4105KNH Nucleic acid-binding protein TD69_19795 ENOG4105XSJ toxin secretion phage lysis holin TD69_19880 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TD69_19890 ENOG4105CAR Terminase, large subunit TD69_19985 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) TD69_19995 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_20050 ENOG4108IMY Transcriptional regulator TD69_20075 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) TD69_20085 ENOG41063PX domain protein TD69_20090 ENOG4105D78 K07001 NTE family protein TD69_20095 ENOG4105H20 Sporulation integral membrane protein YlbJ TD69_20105 ENOG4106H78 methyltransferase TD69_20125 ENOG4107TB6 phosphoglycerate mutase TD69_20140 ENOG4106UY4 Inherit from COG: Scp-like extracellular TD69_20190 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) TD69_20195 ENOG4105CNI cell division protein FtsW TD69_20210 ENOG4108IAB Phoh family TD69_20230 ENOG4105QA2 TD69_20235 ENOG4105CI3 gtp-binding protein typa TD69_20245 ENOG4105ECY inositol monophosphatase TD69_20265 ENOG4105CXN decarboxylase TD69_20310 ENOG4105C7S Dehydrogenase TD69_20315 ENOG4105CPP Dehydrogenase, E1 component TD69_20330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) TD69_20335 ENOG4108X4Q Hydrolase TD69_20345 ENOG4105CN5 Metallo-Beta-Lactamase TD69_20350 ENOG4107ZYR domain protein TD69_20385 ENOG4108XRC Protein of unknown function (DUF458) TD69_20395 ENOG4107IN1 Protein of unknown function (DUF1797) TD69_20410 ENOG4105EPM Diguanylate phosphodiesterase TD69_20415 ENOG4105K6S Short-chain dehydrogenase reductase Sdr TD69_20430 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) TD69_20440 ENOG4105UIN TD69_20505 ENOG4108HGU Histidine kinase TD69_20515 ENOG4105CHM Aminotransferase TD69_20520 ENOG4105FKQ transcriptional regulator TD69_20525 ENOG4105EG2 ABC transporter, permease TD69_20535 ENOG4107FKK extracellular solute-binding protein family 1 TD69_20545 ENOG4105CG3 alpha amylase, catalytic region TD69_20590 ENOG4105CHU acetyl-coa acetyltransferase TD69_20630 ENOG4105K7K Transcriptional regulator TD69_20635 ENOG4105DTD Dehydrogenase TD69_20645 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) TD69_20655 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase TD69_20680 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) TD69_20700 ENOG4106TD9 Diguanylate cyclase TD69_20720 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) TD69_20735 ENOG4105CID antiterminator TD69_20745 ENOG4105FDP GntR family transcriptional regulator TD69_20755 ENOG4105CE4 GlcNAc 6-P deacetylase TD69_20800 ENOG4107ZE5 PPIases accelerate the folding of proteins TD69_20805 ENOG4105PTM secreted protein TD69_20810 ENOG4105J7I hydrolase TD69_20820 ENOG4105G6R Stage v sporulation protein ae TD69_20830 ENOG4105CZ3 stage V sporulation protein ad TD69_20835 ENOG41090VF Stage v sporulation protein ac TD69_20855 ENOG4105C8J )-transporter TD69_20860 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_20870 ENOG41082AN stage II sporulation protein TD69_20875 ENOG4105DZ1 carboxypeptidase TD69_20880 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TD69_20885 ENOG4105DVE abc transporter atp-binding protein TD69_20920 ENOG4105D7N magnesium and cobalt transport protein CorA TD69_20945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TD69_20955 ENOG4105I3K Ferric uptake regulator, Fur family TD69_20960 ENOG4105MZ9 stage II sporulation protein m TD69_20980 ENOG4105CPC Aldo Keto reductase TD69_20990 ENOG4105RHY Pfam:UPF0157 TD69_21010 ENOG4107SKW Inherit from COG: Alpha beta hydrolase TD69_21020 ENOG4105ETE Transcriptional regulator (LacI family TD69_21025 ENOG4108YM7 Gcn5-related n-acetyltransferase TD69_21045 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) TD69_21050 ENOG4108R6K riboflavin synthase, subunit alpha TD69_21070 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) TD69_21075 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TD69_21080 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) TD69_21085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) TD69_21095 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) TD69_21105 ENOG4105DFD Na H antiporter TD69_21110 ENOG4105CGH 5'-nucleotidase TD69_21150 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) TD69_21165 ENOG4108IXY short-chain dehydrogenase reductase TD69_21170 ENOG41069FQ Metallo-beta-lactamase superfamily TD69_21180 ENOG4105II7 pyrroline-5-carboxylate reductase TD69_21185 ENOG4105EJQ L-serine dehydratase TD69_21210 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD69_21220 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) TD69_21225 ENOG4105D9U N-acetyltransferase TD69_21240 ENOG4108VZI ErfK ybiS ycfS ynhG family protein TD69_21245 ENOG4108QEG Membrane TD69_21250 ENOG4105CDA abc transporter atp-binding protein TD69_21255 ENOG4105E5Q amino acid AbC transporter TD69_21260 ENOG4108HW3 (ABC) transporter TD69_21275 ENOG4105G7B Protein of unknown function (DUF2992) TD69_21295 ENOG4105C7S Dehydrogenase TD69_21300 ENOG4105CPP Dehydrogenase, E1 component TD69_21320 ENOG4107RDP Dehydrogenase TD69_21335 ENOG4108JUB Transcriptional regulator TD69_21345 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TD69_21360 ENOG4107QQR Sporulation TD69_21365 ENOG4105S1Z Stage IV sporulation protein B TD69_21370 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) TD69_21380 ENOG4105DX0 Hemolysin A TD69_21390 ENOG4105CTB Polyprenyl synthetase TD69_21415 ENOG4108ZSR alkaline shock protein TD69_21420 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase TD69_21445 ENOG410644B Stage III sporulation protein af TD69_21455 ENOG4105KQ4 Stage iii sporulation protein ad TD69_21460 ENOG4108CQH stage III sporulation protein AC TD69_21465 ENOG4105KR5 Stage iii sporulation protein TD69_21470 ENOG4105CD2 stage iii sporulation protein aa TD69_21495 ENOG4105DC7 peptidase M24 TD69_21510 ENOG4105CBJ Metal-dependent enzyme TD69_21520 ENOG4107YBY Hydrolase TD69_21540 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) TD69_21545 ENOG4105WZW rhodanese family TD69_21565 ENOG41080TC multidrug resistance protein TD69_21605 ENOG4105CJ1 ABC, transporter TD69_21610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family TD69_21640 ENOG4105C0D helicase TD69_21760 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) TD69_21765 ENOG4105C3R Methionine synthase TD69_21780 ENOG4105C28 cystathionine TD69_21785 ENOG4105C28 cystathionine TD69_21810 ENOG4105C5X domain protein TD69_21820 ENOG4105DKQ ROK family TD69_21830 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase TD69_21845 ENOG4108UTW Plays a role in the regulation of phosphate uptake TD69_21850 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) TD69_21855 ENOG4105E2Z phosphate ABC transporter (Permease TD69_21860 ENOG4105C8U phosphate abc transporter TD69_21865 ENOG4105PWN phosphate abc transporter TD69_21870 ENOG4107RF6 penicillin-binding protein TD69_21880 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TD69_21905 ENOG4105N80 Ferric uptake regulator, Fur family TD69_21915 ENOG4105FDK ABC transporter TD69_21920 ENOG4108JYZ YitT family TD69_21925 ENOG41069ZM Protein of unknown function (DUF2624) TD69_21950 ENOG4105EGD dinuclear metal center protein, YbgI family TD69_21965 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_21970 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) TD69_22005 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) TD69_22010 ENOG4105KG3 cytidine deaminase TD69_22015 ENOG4107YR5 Diacylglycerol kinase TD69_22025 ENOG4105CTJ Metal Dependent Phosphohydrolase TD69_22030 ENOG4105C9A Phoh family TD69_22045 ENOG41068P3 sporulation protein YqfC TD69_22050 ENOG4105KTH gatB Yqey TD69_22060 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) TD69_22065 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) TD69_22085 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ TD69_22095 ENOG4105CSA Coproporphyrinogen iii oxidase TD69_22100 ENOG4105KVH Transcriptional regulator TD69_22125 ENOG4105TQK DNA polymerase iii, delta' subunit TD69_22135 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 TD69_22140 ENOG4108UK2 deaminase TD69_22145 ENOG4105KQC Competence protein TD69_22155 ENOG4105DXX methyltransferase TD69_22165 ENOG4108WF2 Metal Dependent Phosphohydrolase TD69_22175 ENOG410812S Rna-binding protein TD69_22185 ENOG4105CQW ribosome biogenesis GTPase YqeH TD69_22190 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase TD69_22205 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_22225 ENOG4108TVJ Nitroreductase TD69_22240 ENOG4105G6Z alkaline phosphatase TD69_22250 ENOG4108MUZ hydrolase TD69_22285 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin TD69_22290 ENOG4105MIR Phenylalanine 4-monooxygenase TD69_22300 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_22305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_22345 ENOG4105S6R Iron-hydroxamate transporter permease subunit TD69_22350 ENOG4108V5C ABC transporter TD69_22360 ENOG4108EKI Dehydrogenase TD69_22365 ENOG4105C28 cystathionine TD69_22395 ENOG4107XRG penicillin-binding protein TD69_22410 ENOG4105CFP Peptidase U32 TD69_22415 ENOG4105XYU peptidase (U32 family) TD69_22420 ENOG4108VQJ O-methyltransferase TD69_22425 ENOG4105HHA aminodeoxychorismate lyase TD69_22445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) TD69_22455 ENOG4105C02 permease TD69_22470 ENOG41060CR TD69_22475 ENOG4105C7H Helicase, RecD TraA family TD69_22485 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) TD69_22490 ENOG4105C3J Cysteine desulfurase TD69_22500 ENOG4105D1H recombination factor protein RarA TD69_22505 ENOG4108VCI transcription factor, rsfa family TD69_22510 ENOG4105CUZ uba thif-type nad fad binding protein TD69_22520 ENOG4105CUT histidyl-tRNA synthetase TD69_22535 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) TD69_22545 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) TD69_22550 ENOG41076HS cation diffusion facilitator family transporter TD69_22555 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) TD69_22565 ENOG4105CKP Polysaccharide Biosynthesis Protein TD69_22570 ENOG4108QG2 Membrane TD69_22580 ENOG4105VIE preprotein translocase, subunit YajC TD69_22595 ENOG41061AI Protein of unknown function (DUF2905) TD69_22610 ENOG4108HUF Transporter TD69_22620 ENOG4108IPJ Membrane TD69_22625 ENOG4108IPJ Membrane TD69_22630 ENOG41082BM Transcriptional regulator, arsr family TD69_22655 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase TD69_22660 ENOG4108IYU L-aspartate oxidase TD69_22675 ENOG4108RPX mosc domain containing protein TD69_22680 ENOG4105CQC Prephenate dehydratase TD69_22700 ENOG4105EWM Histidine kinase TD69_22715 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control TD69_22730 ENOG4105X36 (ribosomal) protein TD69_22740 ENOG4105C03 ribonuclease TD69_22755 ENOG4107QMS site-determining protein TD69_22770 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) TD69_22775 ENOG4105DFF Rod shape-determining protein mreb TD69_22795 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase TD69_22800 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) TD69_22810 ENOG41068KH stage VI sporulation protein D TD69_22820 ENOG4105D52 delta-aminolevulinic acid dehydratase TD69_22845 ENOG4105K56 Transcriptional regulator TD69_22865 ENOG4108IUQ atp-dependent protease TD69_22895 ENOG4108QCI YvbH-like oligomerisation region TD69_22915 ENOG4105M59 Phosphodiesterase, mj0936 family TD69_22920 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) TD69_22930 ENOG4108XJQ germination protein TD69_22940 ENOG4108PCX Major Facilitator TD69_22950 ENOG4105KBX Transcriptional regulator, TetR family TD69_22965 ENOG4105PFC Transcriptional regulator TD69_22980 ENOG4105DZC cytosine deaminase TD69_22985 ENOG4105DZC cytosine deaminase TD69_22990 ENOG4105DEF Extracellular solute-binding protein, family 5 TD69_22995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component TD69_23010 ENOG4108JQ7 (ABC) transporter TD69_23015 ENOG4108HRK Histidine kinase TD69_23020 ENOG4105DY9 regulatoR TD69_23035 ENOG41067S9 phage shock protein C, PspC TD69_23040 ENOG4108JCI Transcriptional regulator TD69_23050 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) TD69_23055 ENOG4108Z40 Transcriptional regulator TD69_23060 ENOG4105RHA ABC transporter, permease TD69_23065 ENOG4108IUX (ABC) transporter TD69_23070 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family TD69_23080 ENOG4105E14 MotA TolQ exbB proton channel TD69_23085 ENOG4108VXD carboxy-peptidase TD69_23095 ENOG4105E33 succinate dehydrogenase TD69_23105 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit TD69_23120 ENOG4105K63 Thioredoxin TD69_23125 ENOG4105C10 Electron transfer flavoprotein TD69_23130 ENOG4105BZJ Electron transfer flavoprotein TD69_23135 ENOG41060WC Enoyl-CoA hydratase TD69_23140 ENOG4107Z3H Transcriptional regulator, TetR family TD69_23145 ENOG4105CEY Amp-dependent synthetase and ligase TD69_23155 ENOG4105J76 Periplasmic binding protein TD69_23160 ENOG4105S6R Iron-hydroxamate transporter permease subunit TD69_23205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_23220 ENOG4105DR4 Methyltransferase TD69_23235 ENOG4105KFN sortase, SrtB family TD69_23240 ENOG4105E0A ABC, transporter TD69_23255 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) TD69_23265 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) TD69_23275 ENOG4105FE9 pseudouridine synthase TD69_23290 ENOG4105DCG PHP domain protein TD69_23325 ENOG4105C5S asparaginyl-tRNA synthetase TD69_23330 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) TD69_23340 ENOG4108RWN rrna methyltransferase TD69_23375 ENOG4105C0R drug resistance transporter emrb qaca subfamily TD69_23380 ENOG4105CW7 secretion protein, HlyD family TD69_23385 ENOG4108JGH Tetr family transcriptional regulator TD69_23390 ENOG4105CN9 Peptidase m42 family protein TD69_23410 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) TD69_23415 ENOG4105C22 threonyL-tRNA synthetase TD69_23420 ENOG4108TDW sporulation protein YtxC TD69_23440 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) TD69_23445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase TD69_23450 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) TD69_23460 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) TD69_23465 ENOG4105C2M dna polymerase I TD69_23470 ENOG4105BZU Histidine kinase TD69_23475 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_23495 ENOG4108HMX isocitrate dehydrogenase (NADP) TD69_23500 ENOG4105BZN citrate synthase TD69_23515 ENOG4108REF Sporulation integral membrane protein ytvi TD69_23520 ENOG4105FS0 cytoplasmic membrane protein TD69_23545 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family TD69_23550 ENOG4105C6K Malic enzyme TD69_23555 ENOG4105C0B DNA polymerase III (alpha subunit) TD69_23560 ENOG4105VV2 TD69_23570 ENOG4105SFS phosphoesterase RecJ domain protein TD69_23605 ENOG4105DC7 peptidase M24 TD69_23640 ENOG4105Z7P Acetyltransferase (GNAT) family TD69_23645 ENOG41082W1 Cupin 2, conserved barrel domain protein TD69_23655 ENOG4105VZ8 Transcriptional regulator TD69_23675 ENOG4107YZX Universal stress protein TD69_23715 ENOG4108JYZ YitT family TD69_23735 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) TD69_23745 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) TD69_23750 ENOG4105KBJ sporulation protein ytfj TD69_23765 ENOG4105EFZ amidohydrolase TD69_23775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) TD69_23800 ENOG4106KR7 LysR family Transcriptional regulator TD69_23820 ENOG4105C28 cystathionine TD69_23840 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TD69_23850 ENOG4105EMN RNA polymerase sigma factor TD69_23865 ENOG4105F1V Acetoin utilization protein TD69_23870 ENOG4105W87 Cbs domain TD69_23875 ENOG4105DGU Histone deacetylase TD69_23885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family TD69_23895 ENOG4107SNB ankyrin repeat protein YahD TD69_23900 ENOG4105EP9 oxidoreductase TD69_23930 ENOG4105ETE Transcriptional regulator (LacI family TD69_23955 ENOG4105C88 aminopeptidase TD69_24000 ENOG4108VDD TRNA binding domain protein TD69_24030 ENOG4105C8F Beta-lactamase domain protein TD69_24045 ENOG4108V15 phosphotransferase enzyme family TD69_24050 ENOG4108IUM Glycogen debranching enzyme TD69_24065 ENOG4107QSE Dipeptidase TD69_24070 ENOG4107QSE Dipeptidase TD69_24075 ENOG4105YW5 deoR family transcriptional regulator TD69_24090 ENOG4105CBX hi0933 family TD69_24125 ENOG4108VJ1 Transcriptional regulator (CarD family TD69_24130 ENOG4107EXU Short-chain dehydrogenase reductase Sdr TD69_24135 ENOG4105CSC Glucose uptake protein TD69_24150 ENOG4108ZAF Molybdopterin TD69_24155 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein TD69_24160 ENOG4105CVM Molybdenum cofactor synthesis domain protein TD69_24170 ENOG4105D06 uba thif-type nad fad binding protein TD69_24195 ENOG41085GJ domain protein TD69_24205 ENOG4105DWV Homoserine O-trans-acetylase TD69_24215 ENOG4108B31 Spore germination protein TD69_24250 ENOG410605W Major Facilitator TD69_24255 ENOG4107S91 Sodium hydrogen exchanger TD69_24260 ENOG4105NCW Trka-c domain protein TD69_24275 ENOG4105C19 ABC transporter TD69_24295 ENOG4105N5T Radical SAM Protein TD69_24305 ENOG4105DA5 (ABC) transporter TD69_24335 ENOG4105E8V Alpha Beta Hydrolase Fold protein TD69_24340 ENOG4108Z0R Transferase TD69_24345 ENOG4105YVM Phosphoesterase, PA-phosphatase related TD69_24350 ENOG4105BZF Glycosyl transferase (Group 1 TD69_24360 ENOG4108RIR Molybdenum cofactor biosynthesis protein TD69_24415 ENOG4105EGD dinuclear metal center protein, YbgI family TD69_24420 ENOG4105BZU Histidine kinase TD69_24425 ENOG4105BZU Histidine kinase TD69_24430 ENOG4107S9D Alpha beta hydrolase TD69_24450 ENOG4105D2X ABC transporter substrate-binding protein TD69_24460 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component TD69_24515 ENOG4108V2W Carbonate dehydratase TD69_24520 ENOG4105C4M (Ubiquinol oxidase) subunit I TD69_24525 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii TD69_24570 ENOG41087YS Phage shock protein A TD69_24605 ENOG4105BZU Histidine kinase TD69_24610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_24635 ENOG4108UGV hypoxanthine phosphoribosyltransferase TD69_24640 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) TD69_24675 ENOG4107ZTW SNARE associated Golgi TD69_24690 ENOG4105C19 ABC transporter TD69_24695 ENOG41086D8 Transcriptional regulator TD69_24745 ENOG4105C6Z Gluconate TD69_24750 ENOG4105FDP GntR family transcriptional regulator TD69_24770 ENOG41069H0 dihydroorotase EC 3.5.2.3 TD69_24800 ENOG4105DTQ mandelate racemase muconate lactonizing TD69_24810 ENOG4108IPT Naphthoate synthase TD69_24815 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) TD69_24820 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) TD69_24825 ENOG4105E4F Isochorismate synthase TD69_24830 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase TD69_24840 ENOG4105VEQ Cold shock protein TD69_24865 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) TD69_24875 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) TD69_24885 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TD69_24980 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation TD69_25015 ENOG4105KT7 mgtC SapB transporter TD69_25020 ENOG4107PBV potassium channel TD69_25030 ENOG4107QYV phosphohexose isomerase TD69_25040 ENOG4105WG9 Conserved Protein TD69_25050 ENOG4105CHM Aminotransferase TD69_25055 ENOG4108ZB6 transcriptional regulator AsnC family TD69_25060 ENOG4105C5I Dehydrogenase TD69_25065 ENOG4108MUZ hydrolase TD69_25075 ENOG4105C87 Aminotransferase class I and II TD69_25090 ENOG4105Y38 Kinase-associated protein B TD69_25100 ENOG4107R3E Citrate transporter TD69_25115 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) TD69_25120 ENOG4105KA0 thioesterase Superfamily protein TD69_25140 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase TD69_25160 ENOG41069ER domain protein TD69_25175 ENOG4105CEP NADH dehydrogenase TD69_25205 ENOG4105EWC Purine nucleoside phosphorylase TD69_25225 ENOG4108YX9 iron--sulfur cluster insertion protein erpA TD69_25250 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) TD69_25255 ENOG4105C4B ABC transporter, permease TD69_25260 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA TD69_25305 ENOG41083MR nifu domain-containing protein TD69_25320 ENOG4108W5N phosphatidylglycerophosphatase a TD69_25335 ENOG4105DYS nad(p)h dehydrogenase (quinone) TD69_25340 ENOG4105D4U had-superfamily hydrolase, subfamily iia TD69_25355 ENOG4105CBT Fructose-1,6-bisphosphatase TD69_25375 ENOG4105MMD transcriptional regulator TD69_25380 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) TD69_25385 ENOG4107TXC Transcriptional regulator TD69_25390 ENOG41090T1 Membrane TD69_25415 ENOG4105FAA peptidase M23 TD69_25425 ENOG4105KZD Domain of unknown function (DUF1805) TD69_25430 ENOG4107R8B 5'-nucleotidase TD69_25455 ENOG4105DIW FeS assembly protein SUFB TD69_25460 ENOG4108UNV SUF system FeS assembly protein, NifU family TD69_25465 ENOG4105C9B Cysteine desulfurase TD69_25470 ENOG4105JRK feS assembly protein SufD TD69_25475 ENOG4105C3K feS assembly ATPase SufC TD69_25480 ENOG4105D01 (LipO)protein TD69_25485 ENOG4105D01 (LipO)protein TD69_25490 ENOG4108UMI ABC transporter, permease TD69_25525 ENOG41080E8 Transcriptional regulator, Spx MgsR family TD69_25575 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) TD69_25605 ENOG4108W8B Beta-lactamase domain protein TD69_25610 ENOG4105C1G acyl-Coa dehydrogenase TD69_25620 ENOG4105CHU acetyl-coa acetyltransferase TD69_25635 ENOG4105DZ1 carboxypeptidase TD69_25655 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer TD69_25675 ENOG4108SUT Major Facilitator Superfamily TD69_25680 ENOG4107R7I amino acid TD69_25690 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TD69_25700 ENOG4107AYK membrAne TD69_25735 ENOG4107ZTW SNARE associated Golgi TD69_25745 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein TD69_25750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_25755 ENOG4105BZU Histidine kinase TD69_25765 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) TD69_25780 ENOG4105VG1 fes assembly suf system protein TD69_25785 ENOG4105D4Y metalloprotease TD69_25805 ENOG4107S91 Sodium hydrogen exchanger TD69_25810 ENOG4105NCW Trka-c domain protein TD69_25825 ENOG4108RMU ferritin dps family protein TD69_25840 ENOG4108URH decarboxylase TD69_25865 ENOG4105D9N nucleoside TD69_25870 ENOG4105D9N nucleoside TD69_25885 ENOG4108RYK Nad-dependent epimerase dehydratase TD69_25900 ENOG4105CV8 reductase TD69_25905 ENOG4105F27 Major Facilitator TD69_25910 ENOG4105KVH Transcriptional regulator TD69_25925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) TD69_25930 ENOG4105D4A Cell wall formation (By similarity) TD69_25940 ENOG4105C8Q Methyl-accepting chemotaxis TD69_25950 ENOG4105WMR Protein CrcB homolog TD69_25955 ENOG4105WMR Protein CrcB homolog TD69_25970 ENOG4108MK9 spermidine N(1)-acetyltransferase TD69_25975 ENOG4108VY7 phosphate-starvation-inducible protein PsiE TD69_25990 ENOG4108IPW abc transporter atp-binding protein TD69_25995 ENOG4105CM4 permease protein TD69_26020 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) TD69_26030 ENOG4105XZU Preprotein translocase, subunit SecG TD69_26035 ENOG41067MG lrgb family TD69_26135 ENOG4105EFC phage portal protein HK97 family TD69_26160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TD69_26170 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) TD69_26175 ENOG4105CP7 Triose-phosphate isomerase TD69_26200 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_26220 ENOG41090VF Stage v sporulation protein ac TD69_26225 ENOG4105CZ3 stage V sporulation protein ad TD69_26240 ENOG4105H67 Protein of unknown function (DUF421) TD69_26245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) TD69_26250 ENOG4105KRI phosphocarrier protein (HPr TD69_26260 ENOG4105CHW UPF0052 protein TD69_26270 ENOG4108Z4K mutator MutT protein TD69_26280 ENOG4105C3M thioredoxin reductase TD69_26290 ENOG4108S4C acetyltransferase TD69_26310 ENOG41086DT Membrane protein of unknown function TD69_26320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) TD69_26325 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) TD69_26330 ENOG4105D7V transposase TD69_26345 ENOG4107TXC Transcriptional regulator TD69_26370 ENOG4105HMI Membrane TD69_26375 ENOG4105DUM transcriptional regulator, lysR family TD69_26385 ENOG4108WS4 fmn reductase TD69_26400 ENOG4105BZ1 (ABC) transporter TD69_26410 ENOG4105CN1 protease TD69_26415 ENOG4105CRP Part of the ABC transporter FtsEX involved in TD69_26420 ENOG4105CAK Cell division ATP-binding protein ftsE TD69_26435 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) TD69_26440 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving TD69_26445 ENOG4105MS2 ribosomal subunit Interface protein TD69_26450 ENOG4105VEQ Cold shock protein TD69_26455 ENOG41081UC Inherit from COG: Competence protein TD69_26470 ENOG4105KVH Transcriptional regulator TD69_26485 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein TD69_26490 ENOG4108KGH TRANSCRIPTIONal TD69_26495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase TD69_26500 ENOG4105C6Y Udp-glucose 6-dehydrogenase TD69_26505 ENOG4105ESV Glycosyl transferase, family 4 TD69_26515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family TD69_26530 ENOG410901P UPF0249 protein TD69_26535 ENOG4105F8D glycoside hydrolase family 4 TD69_26540 ENOG4105VCP PTS System TD69_26545 ENOG4105CK1 PTS System TD69_26555 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) TD69_26560 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) TD69_26565 ENOG4105VCP PTS System TD69_26575 ENOG4105VZJ PTS System TD69_26590 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase TD69_26595 ENOG4105ECB domain protein TD69_26600 ENOG4107RSM transcriptional regulator TD69_26645 ENOG4105DAA L-lactate TD69_26655 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) TD69_26665 ENOG4105E0M Sulfatase TD69_26700 ENOG4105C94 Transporter TD69_26705 ENOG41069ER domain protein TD69_26730 ENOG4105KBK Zinc finger, swim domain protein TD69_26735 ENOG4105C0D helicase TD69_26765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) TD69_26775 ENOG4107RBB ABC transporter, permease TD69_26780 ENOG4105C19 ABC transporter TD69_26800 ENOG4105CXY transporter TD69_26815 ENOG4105BZU Histidine kinase TD69_26820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_26825 ENOG4105CMR udp-glucose 4-epimerase TD69_26845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase TD69_26850 ENOG4105EY8 ABC transporter TD69_26905 ENOG4105MT0 Sporulation transcriptional regulator spoiiid TD69_26920 ENOG4105FRN stage II sporulation protein TD69_26935 ENOG4105DY9 regulatoR TD69_26940 ENOG4108IUW ABC transporter TD69_26960 ENOG4106778 Protein of unknown function (DUF1146) TD69_26965 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TD69_26970 ENOG4105C8S subunit m TD69_26975 ENOG4105D65 subunit l TD69_27000 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) TD69_27005 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain TD69_27015 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain TD69_27020 ENOG4105BZU Histidine kinase TD69_27070 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) TD69_27075 ENOG41062M3 atp synthase TD69_27105 ENOG4108YZG isomerase TD69_27120 ENOG4108VGI doxx family TD69_27125 ENOG4107XC4 flavin reductase domain protein, FMN-binding TD69_27140 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) TD69_27150 ENOG4108ZXQ stage ii sporulation protein r TD69_27155 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) TD69_27160 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) TD69_27175 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) TD69_27180 ENOG4105CBT Fructose-1,6-bisphosphatase TD69_27185 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) TD69_27220 ENOG4105C1G acyl-Coa dehydrogenase TD69_27225 ENOG4105C1G acyl-Coa dehydrogenase TD69_27230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase TD69_27240 ENOG4105DF6 Fe-S oxidoreductase TD69_27255 ENOG4105BZU Histidine kinase TD69_27275 ENOG4105BZU Histidine kinase TD69_27280 ENOG4105KCT ABC transporter TD69_27285 ENOG4108M15 ABC transporter TD69_27290 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) TD69_27310 ENOG4105IIU Aminopeptidase TD69_27330 ENOG4105EMN RNA polymerase sigma factor TD69_27340 ENOG410684U Domain of unknown function (DUF1934) TD69_27365 ENOG4105CYW agmatinase TD69_27375 ENOG4105DXB Major Facilitator superfamily TD69_27380 ENOG4107SWG transcriptional regulator MERR family TD69_27385 ENOG4108QXE glycerophosphoryl diester phosphodiesterase TD69_27390 ENOG4105BZ4 penicillin-binding protein TD69_27395 ENOG4108XFG YwhD family TD69_27400 ENOG4108Z4T Peptidase M50 TD69_27405 ENOG41069HH 4-oxalocrotonate tautomerase TD69_27410 ENOG4105DCI Phosphohydrolase TD69_27415 ENOG4108MES Periplasmic binding protein TD69_27420 ENOG4105E0A ABC, transporter TD69_27425 ENOG4105EHG Permease protein TD69_27430 ENOG4105DQ5 transport system permease protein TD69_27435 ENOG4105DQ5 transport system permease protein TD69_27445 ENOG4108VCI transcription factor, rsfa family TD69_27460 ENOG4108IJ2 phosphate acetyltransferase TD69_27475 ENOG4108VKI Cell wall hydrolase TD69_27505 ENOG410667J hydrolase TD69_27510 ENOG4105VCH membrane TD69_27520 ENOG4108TU7 Inherit from COG: (ABC) transporter TD69_27525 ENOG4105CJ1 ABC, transporter TD69_27530 ENOG41090WU lipolytic protein G-D-S-L family TD69_27545 ENOG4105D6E homoserine dehydrogenase TD69_27570 ENOG4108Y4K DNA-binding transcriptional activator TD69_27580 ENOG4105WH1 Two component transcriptional regulator luxr family TD69_27590 ENOG4105DWF phosphomethylpyrimidine kinase TD69_27595 ENOG4105BZU Histidine kinase TD69_27600 ENOG4105VCD cytoplasmic protein TD69_27605 ENOG4105D22 carbon starvation protein TD69_27610 ENOG4105DY9 regulatoR TD69_27615 ENOG41079KZ Major Facilitator Superfamily TD69_27635 ENOG4105EN6 Membrane TD69_27640 ENOG4106YBV Methyl-accepting chemotaxis TD69_27650 ENOG4108S4H thioesterase Superfamily protein TD69_27660 ENOG4105JEU Glycosyl transferase, family 2 TD69_27665 ENOG4105C5H ABC transporter TD69_27690 ENOG4105CKK Glycosyl transferase, family 2 TD69_27695 ENOG41067SE Tetr family transcriptional regulator TD69_27705 ENOG4105E0X reductase TD69_27710 ENOG4106F5Q Membrane TD69_27725 ENOG4105DY9 regulatoR TD69_27730 ENOG4108HRK Histidine kinase TD69_27735 ENOG4107RGD Major Facilitator superfamily TD69_27750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) TD69_27760 ENOG4105IW1 AmiS UreI transporter TD69_27770 ENOG4105CMR udp-glucose 4-epimerase TD69_27775 ENOG4108UT2 hemolysin iii TD69_27785 ENOG4105C1J atp-dependent rna helicase TD69_27800 ENOG4105DPN Oligoendopeptidase f TD69_27820 ENOG4105C0H protease TD69_27825 ENOG4105Q2H domain protein TD69_27840 ENOG4105BZU Histidine kinase TD69_27845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family TD69_27875 ENOG4105CDU Replicative dna helicase TD69_27885 ENOG4105BZR domain protein TD69_27890 ENOG4108XMW Membrane TD69_27900 ENOG4108UUM single-stranded DNA-binding protein TD69_27910 ENOG4105C3G gtp-binding protein TD69_27915 ENOG4105VDK protein, conserved in bacteria TD69_27920 ENOG4105D8X mechanosensitive ion channel TD69_27925 ENOG4108ZDA Sporulation protein YyaC TD69_27930 ENOG4105FA0 parb-like partition protein TD69_27935 ENOG4107QJE Chromosome Partitioning Protein TD69_27955 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) TD69_27965 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins TD69_28025 ENOG4105EKQ RNA-directed DNA polymerase TD69_28105 ENOG4105EKQ RNA-directed DNA polymerase TD69_28220 ENOG4105CNU cell division protein FtsK TD69_28445 ENOG4105DHF Membrane TD69_28470 ENOG4106AKK s-layer domain-containing protein TD69_28475 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase TD69_28500 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase TD69_28505 ENOG4105C6Y Udp-glucose 6-dehydrogenase TD69_28520 ENOG4105DQ6 Transposase TD69_28560 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) TD69_28675 ENOG4105KRN Transcriptional regulator, abrb family TD69_28685 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) TD69_28715 ENOG4108IBT Inherit from COG: transposase TD69_28725 ENOG4105DQ6 Transposase TD69_28745 ENOG4108MEK Metal-binding protein YodA TD69_28755 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) TD69_28785 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) TD69_28865 ENOG4105K4H Nlp p60 protein TD69_29010 ENOG4107QJE Chromosome Partitioning Protein TD69_29055 ENOG4105EWC Purine nucleoside phosphorylase TD69_29120 ENOG4105C3F Signal peptidase i TD69_29150 ENOG4105N14 lysine exporter protein LysE YggA TD69_29190 ENOG4108J59 Extracellular solute-binding protein, family 5 TD69_29205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) TD69_29265 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) TD69_29270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)