locus-tag class description BF89_1 ENOG4107QX3 carboxylase BF89_100 ENOG4108JCI Transcriptional regulator BF89_1002 ENOG4108S6Z Negative regulator of genetic competence BF89_1003 ENOG4107X2D transcriptional regulator, merr family BF89_1004 ENOG4107RGJ metallophosphoesterase BF89_1006 ENOG4105I7S Abortive infection protein BF89_1007 ENOG4105C9U ATP-dependent DNA helicase RecQ BF89_1008 ENOG4105T7X BF89_1010 ENOG4108SAX Membrane BF89_1013 ENOG4108WBT adenosyltransferase BF89_1014 ENOG4105BZU Histidine kinase BF89_1015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_1016 ENOG4105CRE cytochrome C BF89_1017 ENOG4107TWT Cytochrome c biogenesis protein BF89_1019 ENOG4105FE9 pseudouridine synthase BF89_1021 ENOG4108JIC nucleoside recognition domain protein BF89_1022 ENOG4105DZ1 carboxypeptidase BF89_1023 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF89_1030 ENOG4105BZU Histidine kinase BF89_1033 ENOG4105I3N Conserved Protein BF89_1034 ENOG4105BZU Histidine kinase BF89_1037 ENOG4105BZ4 penicillin-binding protein BF89_1038 ENOG4107GRR phosphate transport regulator BF89_1039 ENOG4105CJ3 phosphate transporter BF89_104 ENOG4105BZ1 (ABC) transporter BF89_1043 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF89_1048 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF89_105 ENOG4105BZ1 (ABC) transporter BF89_1052 ENOG4105WH1 Two component transcriptional regulator luxr family BF89_1053 ENOG4105ENE Histidine kinase BF89_1057 ENOG4105DFD Na H antiporter BF89_1061 ENOG4105C8J )-transporter BF89_1062 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF89_1063 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF89_1064 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF89_1066 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF89_1067 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF89_1071 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF89_1073 ENOG4105E0M Sulfatase BF89_1074 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF89_1077 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF89_108 ENOG4108RPX mosc domain containing protein BF89_1084 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF89_1089 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF89_109 ENOG4105DND Transcriptional regulator BF89_1091 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF89_1092 ENOG4108ZP8 Acetolactate synthase small subunit BF89_1093 ENOG4105C7K acetolactate synthase BF89_1094 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF89_1099 ENOG4105KBJ sporulation protein ytfj BF89_11 ENOG4105CJ1 ABC, transporter BF89_1100 ENOG41063Y9 BF89_1101 ENOG4105CZN Potassium uptake protein BF89_1107 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF89_1108 ENOG4107QMU Mate efflux family protein BF89_1115 ENOG4105NQC Flavodoxin BF89_112 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF89_1120 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF89_1122 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF89_1123 ENOG4105EA8 2-Nitropropane dioxygenase BF89_1124 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF89_113 ENOG4107V2S Transcriptional regulator BF89_1132 ENOG4105CJ1 ABC, transporter BF89_1134 ENOG4105CZV ABC transporter BF89_1135 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF89_1136 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF89_1137 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF89_1139 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF89_1140 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF89_1148 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF89_1149 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF89_1151 ENOG4105BZU Histidine kinase BF89_1153 ENOG4106DF1 BF89_1155 ENOG41090MY MarR family Transcriptional regulator BF89_1156 ENOG4105BZU Histidine kinase BF89_1158 ENOG4105PXI polysaccharide deacetylase BF89_1160 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF89_1161 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF89_1166 ENOG4105E98 transcriptional regulator DeoR family BF89_1170 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF89_1171 ENOG4107RCV ABC transporter, permease BF89_1174 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF89_1176 ENOG4105C4Y ABC transporter BF89_1180 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF89_1182 ENOG4105CHR reductase BF89_1186 ENOG4108Z7G MaoC domain protein dehydratase BF89_1187 ENOG410681C small acid-soluble spore protein BF89_1188 ENOG4105CZN Potassium uptake protein BF89_1190 ENOG4107TS3 membrane protein, TerC BF89_1191 ENOG4108QTI )-transporter BF89_1193 ENOG4106A3R peptidase BF89_1197 ENOG4105JXH GntR family transcriptional regulator BF89_1198 ENOG4105BZU Histidine kinase BF89_1199 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_1202 ENOG4105CQB FAD linked oxidase domain protein BF89_1203 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF89_1204 ENOG4105K4I Scp-like extracellular BF89_1206 ENOG4108YBP pseudouridine synthase BF89_1208 ENOG4105EYF MMPL domain protein BF89_121 ENOG410667J hydrolase BF89_1210 ENOG4107RUE extracellular solute-binding protein family 1 BF89_1211 ENOG4105D38 putrescine abc transporter BF89_1212 ENOG4105F38 ABC transporter, permease BF89_1213 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF89_1214 ENOG4105C26 Dehydrogenase BF89_1220 ENOG4105VFR signal peptidase BF89_1221 ENOG4105DZ1 carboxypeptidase BF89_1223 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF89_1234 ENOG4105VZ8 Transcriptional regulator BF89_1236 ENOG4105C7S Dehydrogenase BF89_125 ENOG4105VEQ Cold shock protein BF89_1254 ENOG4105DDQ anthranilate synthase BF89_1255 ENOG4105CRQ synthase (Component I) BF89_1256 ENOG4105CK7 Sodium proline symporter BF89_1261 ENOG4108WVJ 2'-5' rna ligase BF89_127 ENOG41068WN BF89_1270 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF89_1272 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF89_1273 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF89_1277 ENOG4107TVC Glycosyl transferase, family 2 BF89_1281 ENOG4105K64 Glycosyl transferase, family 2 BF89_1283 ENOG4105CNI cell division protein FtsW BF89_1286 ENOG4105EMS pseudouridine synthase BF89_1287 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF89_129 ENOG4105C1Q protoporphyrinogen oxidase BF89_1290 ENOG4105MIX Adenylate cyclase BF89_1291 ENOG4108Z18 K06886 hemoglobin BF89_1294 ENOG4105DPN Oligoendopeptidase f BF89_1296 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF89_1298 ENOG4108ZCF integral membrane protein BF89_1302 ENOG4105UQX Mate efflux family protein BF89_1303 ENOG4108JQ7 (ABC) transporter BF89_1305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF89_1306 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF89_1309 ENOG4105C31 Tryptophanyl-tRNA synthetase BF89_1312 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF89_1313 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF89_1318 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF89_1320 ENOG4108KP7 hydrolase BF89_1322 ENOG41073B9 BF89_1323 ENOG4107AYK membrAne BF89_1324 ENOG4107AYK membrAne BF89_1326 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF89_1328 ENOG4105QNR S1 RNA binding domain protein BF89_1333 ENOG4105BZU Histidine kinase BF89_1334 ENOG4105CH6 catalase BF89_1335 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF89_1336 ENOG4105CAQ asparagine synthetase BF89_1341 ENOG4105ERH Fumarylacetoacetate hydrolase BF89_1349 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF89_135 ENOG4105WCN acetyltransferase BF89_1350 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF89_1353 ENOG4105XVF Competence transcription factor BF89_1356 ENOG4105VEQ Cold shock protein BF89_1359 ENOG4107QP3 malate synthase g BF89_1360 ENOG4105ZU5 s-layer protein BF89_1364 ENOG4105C8Q Methyl-accepting chemotaxis BF89_1365 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF89_1370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_1374 ENOG41086D8 Transcriptional regulator BF89_1375 ENOG4108AEY RNA polymerase sigma factor BF89_1377 ENOG4107TVP HD domain protein BF89_1378 ENOG4107RN3 metallophosphoesterase BF89_1380 ENOG4105ENX hydrolase BF89_1385 ENOG4105CNA YD repeat protein BF89_1391 ENOG4105CEY Amp-dependent synthetase and ligase BF89_1393 ENOG4105DF9 Lipoate-protein, ligase BF89_1394 ENOG4108RQ5 Beta-lactamase domain-containing protein BF89_1395 ENOG4106AXD BF89_14 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF89_140 ENOG4105EYF MMPL domain protein BF89_1401 ENOG4105ECB domain protein BF89_1404 ENOG4105NA0 Transcriptional regulator BF89_1409 ENOG4105C1Q protoporphyrinogen oxidase BF89_1411 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF89_1412 ENOG4105BZ4 penicillin-binding protein BF89_1413 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF89_1414 ENOG4105CKV Membrane BF89_1415 ENOG410905X membrane-flanked domain protein BF89_142 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF89_1423 ENOG4105CKV Membrane BF89_1425 ENOG410905X membrane-flanked domain protein BF89_1432 ENOG4105K59 histidine triad (HIT) protein BF89_1437 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF89_1438 ENOG4105EEM helicase BF89_1440 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_1441 ENOG4105C57 major facilitator superfamily BF89_1446 ENOG4105EMN RNA polymerase sigma factor BF89_1449 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF89_145 ENOG41081I9 integral membrane protein BF89_1452 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF89_1457 ENOG4108MUZ hydrolase BF89_1461 ENOG4105EQ0 Major Facilitator superfamily BF89_1462 ENOG4108IND Tetr family transcriptional regulator BF89_1465 ENOG4105D7V transposase BF89_1466 ENOG4106D4I domain protein BF89_1467 ENOG4107VRP DNA repair exonuclease BF89_1473 ENOG4105K8R UPF0145 protein BF89_1478 ENOG4105BZU Histidine kinase BF89_1479 ENOG4105BZU Histidine kinase BF89_1480 ENOG4108MJI response regulator BF89_1482 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_1484 ENOG4105WN5 stage II sporulation protein BF89_1498 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF89_1503 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF89_1504 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF89_1505 ENOG4105CMT Dihydroxyacetone kinase BF89_1507 ENOG4105CMT Dihydroxyacetone kinase BF89_151 ENOG4108D32 Methyltransferase BF89_1511 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF89_1515 ENOG4108IG5 Transcriptional regulator BF89_1516 ENOG4107P5I polyketide synthase BF89_1527 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_1535 ENOG4105CDU Replicative dna helicase BF89_1544 ENOG4108MRH transcriptional regulatory protein BF89_1546 ENOG4105CSH Transporter BF89_1552 ENOG4108JQ7 (ABC) transporter BF89_1555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF89_1563 ENOG4105CTU Proline racemase BF89_1567 ENOG4105DER m42 family BF89_157 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF89_1570 ENOG4105CGU Enoyl-CoA hydratase BF89_1573 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF89_1574 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF89_1576 ENOG4106AKK s-layer domain-containing protein BF89_1584 ENOG4105CHH sulfate transporter BF89_1587 ENOG4105D4P Coproporphyrinogen iii oxidase BF89_1589 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF89_1594 ENOG4107FQX Alpha-acetolactate decarboxylase BF89_160 ENOG4105C19 ABC transporter BF89_1601 ENOG410839P BF89_1604 ENOG4105CDA abc transporter atp-binding protein BF89_1605 ENOG4105DRP amino acid AbC transporter BF89_1607 ENOG4105BZ1 (ABC) transporter BF89_1608 ENOG4105BZ1 (ABC) transporter BF89_1609 ENOG4105BZ1 (ABC) transporter BF89_161 ENOG4105C22 threonyL-tRNA synthetase BF89_1610 ENOG4105C26 Dehydrogenase BF89_1612 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF89_1613 ENOG4105D5Q Arginine ornithine antiporter BF89_1615 ENOG4105CH6 catalase BF89_1616 ENOG4107RKG DJ-1/PfpI family BF89_1618 ENOG410605W Major Facilitator BF89_1619 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF89_162 ENOG4105FE9 pseudouridine synthase BF89_1620 ENOG4105NF4 modulator of drug activity BF89_1625 ENOG4105KPY Small multidrug resistance protein BF89_1626 ENOG4105KPY Small multidrug resistance protein BF89_1628 ENOG4108YXU transcriptional regulator AsnC family BF89_1629 ENOG4108PCN EamA-like transporter family BF89_1636 ENOG4106KNT transcriptional regulator BF89_1638 ENOG4107RWR Sodium hydrogen exchanger BF89_1639 ENOG4105CUB amino acid BF89_1646 ENOG4107T5V SNARE associated Golgi BF89_1653 ENOG4105WEF catalase BF89_1659 ENOG4105C19 ABC transporter BF89_166 ENOG4105BZG amino acid carrier protein BF89_1660 ENOG4107RBB ABC transporter, permease BF89_1661 ENOG41069ER domain protein BF89_1665 ENOG4105VZJ PTS System BF89_1666 ENOG4105VCP PTS System BF89_1667 ENOG4105EMD TRANSCRIPTIONal BF89_167 ENOG4105BZG amino acid carrier protein BF89_1672 ENOG4108KGH TRANSCRIPTIONal BF89_1674 ENOG41087NI Sulfite exporter TauE/SafE BF89_1675 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF89_1677 ENOG41085GJ domain protein BF89_1679 ENOG4105VFE sira family BF89_1680 ENOG4107TPS domain protein BF89_1681 ENOG4105VFE sira family BF89_1682 ENOG4105XTG Pfam:DUF156 BF89_1683 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF89_1688 ENOG4105ED1 spovr family BF89_1689 ENOG4107Y03 Nitroreductase BF89_1693 ENOG4108B31 Spore germination protein BF89_17 ENOG4106ANW SMI1_KNR4 BF89_1700 ENOG4105C5Y PTS System BF89_1704 ENOG4108PXI ErfK YbiS YcfS YnhG BF89_1706 ENOG4105C7N Xanthine uracil vitamin C permease BF89_1709 ENOG4108INS Transcriptional regulator BF89_171 ENOG4105K70 DNA-binding protein BF89_1718 ENOG4105DWF phosphomethylpyrimidine kinase BF89_1719 ENOG4105D06 uba thif-type nad fad binding protein BF89_1722 ENOG41080HI glycine oxidase BF89_1723 ENOG4108VEU Thiamine monophosphate synthase BF89_1725 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF89_1727 ENOG4105ETU transcriptional activator (TenA BF89_1731 ENOG41080XQ Signal transduction protein with cbs domains BF89_174 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_175 ENOG4105WQT MbtH domain protein BF89_1758 ENOG4105E2Z phosphate ABC transporter (Permease BF89_1759 ENOG4105C8U phosphate abc transporter BF89_176 ENOG4105CEY Amp-dependent synthetase and ligase BF89_1760 ENOG4105CVA phosphate BF89_1761 ENOG4105CE1 Ferrous iron transport protein b BF89_1762 ENOG4105CE1 Ferrous iron transport protein b BF89_1763 ENOG4105CE1 Ferrous iron transport protein b BF89_1764 ENOG4108NHD germination protein BF89_1767 ENOG4105E1V na solute symporter BF89_1768 ENOG4106CAD Protein of unknown function (DUF3311) BF89_177 ENOG4105CEY Amp-dependent synthetase and ligase BF89_1771 ENOG4105E2S oxidase) subunit II BF89_1772 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF89_178 ENOG4105WQI isochorismatase BF89_1780 ENOG4105C7N Xanthine uracil vitamin C permease BF89_1781 ENOG4105C85 amino acid BF89_1785 ENOG4105DUX Transporter BF89_1787 ENOG4107D63 BF89_1788 ENOG4105VZ8 Transcriptional regulator BF89_1789 ENOG41069ER domain protein BF89_179 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF89_1790 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF89_1791 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF89_180 ENOG4105E4F Isochorismate synthase BF89_1803 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF89_1804 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF89_1805 ENOG4105CNN ABC, transporter BF89_1806 ENOG4105C2J ABC transporter BF89_1808 ENOG4108RVA ribokinase BF89_1809 ENOG4105ETE Transcriptional regulator (LacI family BF89_181 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF89_1810 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_1811 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_1812 ENOG41067TZ transcriptional regulator, MarR family BF89_1813 ENOG4105CXY transporter BF89_1815 ENOG4108JQ7 (ABC) transporter BF89_1816 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF89_1818 ENOG4105DEF Extracellular solute-binding protein, family 5 BF89_182 ENOG4105FCD Major Facilitator BF89_1820 ENOG41068KF Universal stress protein BF89_1821 ENOG4105CHH sulfate transporter BF89_1824 ENOG4105BZU Histidine kinase BF89_1825 ENOG4105NAE bifunctional deaminase-reductase domain protein BF89_1826 ENOG4105D29 Helix-turn-helix type 11 domain protein BF89_1831 ENOG4108IQI permease BF89_1832 ENOG4105DRP amino acid AbC transporter BF89_1833 ENOG4105EAD ABC transporter BF89_1834 ENOG4105CT1 (ABC) transporter BF89_1835 ENOG4105CDA abc transporter atp-binding protein BF89_1836 ENOG4105BZG amino acid carrier protein BF89_1837 ENOG4105CRN Aminoglycoside phosphotransferase BF89_1839 ENOG4105E1K spore germination protein BF89_1842 ENOG4105CG3 alpha amylase, catalytic region BF89_1843 ENOG4105C5Y PTS System BF89_1844 ENOG4107414 GntR family transcriptional regulator BF89_1845 ENOG4105D5Q Arginine ornithine antiporter BF89_1846 ENOG4105BZU Histidine kinase BF89_1849 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF89_1850 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF89_1851 ENOG4107T89 von Willebrand factor, type A BF89_1853 ENOG4105EXW epimerase dehydratase BF89_1855 ENOG4105DMQ Methyltransferase BF89_1856 ENOG4105E0A ABC, transporter BF89_1857 ENOG4108IHU transport system permease protein BF89_1858 ENOG4105DQ5 transport system permease protein BF89_1859 ENOG4108MES Periplasmic binding protein BF89_186 ENOG4105EYH Exonuclease BF89_1860 ENOG4105DUX Transporter BF89_1863 ENOG4105DAA L-lactate BF89_1864 ENOG4108IJ0 Aspartate ammonia-lyase BF89_1865 ENOG4105C37 (CBS) domain BF89_1866 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF89_1867 ENOG4105D9N nucleoside BF89_1868 ENOG4108KGH TRANSCRIPTIONal BF89_1869 ENOG41073R8 VanW family BF89_187 ENOG4107RFY SbcCD D subunit BF89_1876 ENOG4105DAP Nicotinate phosphoribosyltransferase BF89_1877 ENOG4105C59 p-type ATPase BF89_1879 ENOG4105CUB amino acid BF89_1884 ENOG4108JB9 formate dehydrogenase BF89_1885 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF89_1886 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF89_1888 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_1889 ENOG4105BZU Histidine kinase BF89_1891 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF89_1892 ENOG4108UZ3 Transporter BF89_1894 ENOG4105C6K Malic enzyme BF89_1896 ENOG4108MRH transcriptional regulatory protein BF89_19 ENOG4105BZU Histidine kinase BF89_190 ENOG4105E39 Enoyl-CoA hydratase BF89_1901 ENOG4105US7 Histidine kinase BF89_1902 ENOG4108STX response regulator BF89_1903 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF89_1904 ENOG4105BZ7 extracellular solute-binding protein family 1 BF89_1906 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF89_1907 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF89_1908 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF89_1909 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF89_191 ENOG4105N14 lysine exporter protein LysE YggA BF89_1913 ENOG4105D4T Citrate transporter BF89_1914 ENOG4108MRH transcriptional regulatory protein BF89_1915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF89_1917 ENOG4105DZ6 Band 7 protein BF89_1920 ENOG4105C94 Transporter BF89_1924 ENOG4105CYN Serine protein kinase BF89_1926 ENOG4105BZU Histidine kinase BF89_1927 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF89_1929 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF89_193 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF89_1931 ENOG4107ZQN disulfide bond BF89_1932 ENOG4108JQC penicillin-binding protein 1A BF89_194 ENOG4105C1G acyl-Coa dehydrogenase BF89_195 ENOG4105CR4 methylisocitrate lyase BF89_1957 ENOG4105G5W regulator Fur family BF89_1958 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF89_196 ENOG4105DXD 2-methylcitrate dehydratase BF89_1962 ENOG4108IUW ABC transporter BF89_1964 ENOG4105CBC glutamate synthase BF89_1965 ENOG4107NBY Membrane BF89_1966 ENOG4105BZ1 (ABC) transporter BF89_1970 ENOG4106BXE BF89_1971 ENOG4105CEN a g-specific adenine glycosylase BF89_1972 ENOG41067AE Membrane-bound metal-dependent hydrolase BF89_1978 ENOG4105ECP epimerase BF89_1979 ENOG4105CI2 imidazolone-5-propionate hydrolase BF89_198 ENOG4105W8X HesB YadR YfhF-family protein BF89_1983 ENOG4105F1A Pyruvate formate-lyase BF89_1986 ENOG4105C3I Nad-dependent epimerase dehydratase BF89_1987 ENOG4107QQG Dehydrogenase BF89_1989 ENOG4105CKK Glycosyl transferase, family 2 BF89_199 ENOG4105CZM Major Facilitator BF89_1992 ENOG4108A04 Beta-lactamase BF89_1994 ENOG4105CSV Glutaminase BF89_2 ENOG4105E39 Enoyl-CoA hydratase BF89_200 ENOG4105BZ4 penicillin-binding protein BF89_2000 ENOG4108IQI permease BF89_2002 ENOG4108JUB Transcriptional regulator BF89_2004 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF89_2062 ENOG4105VTR Integrase BF89_2063 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF89_2071 ENOG4105UPD Calcium Proton BF89_2072 ENOG410606W general stress protein BF89_2075 ENOG4107ZTW SNARE associated Golgi BF89_2078 ENOG4105C3F Signal peptidase i BF89_208 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF89_2080 ENOG4108IPJ Membrane BF89_2081 ENOG4105C59 p-type ATPase BF89_2082 ENOG4107U9T Pfam:Ribonuclease_BN BF89_2084 ENOG4105KJF protein tyrosine phosphatase BF89_2088 ENOG4108TTB tellurium resistance protein BF89_2089 ENOG4107TS3 membrane protein, TerC BF89_2090 ENOG4106FN3 tellurium resistance protein BF89_2091 ENOG4106FN3 tellurium resistance protein BF89_2092 ENOG4108N0M stress protein BF89_2095 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF89_2098 ENOG4105DEU major facilitator superfamily BF89_21 ENOG4105C5H ABC transporter BF89_2102 ENOG41062JF Transcriptional regulator BF89_2108 ENOG4105C5H ABC transporter BF89_2111 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF89_2114 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF89_2120 ENOG4105CI1 PTS System BF89_2122 ENOG4105C8Q Methyl-accepting chemotaxis BF89_2123 ENOG4105C8Q Methyl-accepting chemotaxis BF89_2125 ENOG4105EAB amino acid AbC transporter BF89_2126 ENOG4105E5Q amino acid AbC transporter BF89_2129 ENOG4105D2S major facilitator superfamily BF89_2130 ENOG410756H nucleotidyltransferase BF89_2134 ENOG4105BZU Histidine kinase BF89_2138 ENOG4106UIA BF89_2139 ENOG4106UIA BF89_2143 ENOG4108V5C ABC transporter BF89_2144 ENOG4105DQ5 transport system permease protein BF89_2145 ENOG4105EHG Permease protein BF89_2146 ENOG4107W7X Aldolase BF89_2148 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF89_2149 ENOG4105D3R alkyl hydroperoxide reductase BF89_2154 ENOG4105DFD Na H antiporter BF89_2155 ENOG4105DTQ mandelate racemase muconate lactonizing BF89_2158 ENOG4108W15 Protein of unknown function (DUF1456) BF89_2161 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF89_2162 ENOG4105D9N nucleoside BF89_2166 ENOG4105KPY Small multidrug resistance protein BF89_2167 ENOG4105C26 Dehydrogenase BF89_2169 ENOG4108JPW Aminotransferase BF89_2170 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF89_2171 ENOG4105CBD Diacylglycerol kinase BF89_2175 ENOG4107I77 yiaA/B two helix domain BF89_2176 ENOG410834F Transcriptional regulator BF89_2177 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF89_2181 ENOG4105D01 (LipO)protein BF89_2182 ENOG4108UMI ABC transporter, permease BF89_2183 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF89_2184 ENOG4108W2Y isochorismatase BF89_2190 ENOG4105C4R Atp-dependent dna helicase BF89_2195 ENOG4105C12 Phosphoribosylglycinamide synthetase BF89_2197 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF89_22 ENOG41067SE Tetr family transcriptional regulator BF89_2202 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF89_2204 ENOG4105C83 adenylosuccinate lyase BF89_2205 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF89_2206 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF89_2211 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_2215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF89_2221 ENOG4105BZU Histidine kinase BF89_2223 ENOG4105C7N Xanthine uracil vitamin C permease BF89_2227 ENOG4108TYN CAAX amino terminal protease family protein BF89_2230 ENOG4105C5H ABC transporter BF89_2231 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF89_2232 ENOG410801F ribosomal-protein-alanine acetyltransferase BF89_2233 ENOG41072GX Peptidase M22 Glycoprotease BF89_2234 ENOG4105K8N protein family UPF0079, ATPase BF89_2254 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF89_2256 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF89_2257 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF89_2260 ENOG4107ZXI Rhomboid family BF89_2262 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF89_2263 ENOG4105CPF Cell wall formation (By similarity) BF89_2264 ENOG4105CPF Cell wall formation (By similarity) BF89_2265 ENOG4108SC4 )-transporter BF89_2267 ENOG4105ERH Fumarylacetoacetate hydrolase BF89_2268 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF89_227 ENOG4108IBT Inherit from COG: transposase BF89_2273 ENOG410667J hydrolase BF89_2274 ENOG4108JQ7 (ABC) transporter BF89_2275 ENOG4105C3U ABC transporter BF89_2276 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF89_2278 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF89_2281 ENOG4105C5H ABC transporter BF89_2285 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF89_2286 ENOG4108RE7 deoxyribonuclease BF89_2289 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF89_229 ENOG4105SZ6 Thioredoxin BF89_2293 ENOG4105F6E Acyl-transferase BF89_2297 ENOG4105EGI Transcriptional regulator BF89_230 ENOG410841Q phosphoesterase PA-phosphatase related protein BF89_2300 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF89_2301 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF89_2302 ENOG4105E0C molybdate abc transporter BF89_2304 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF89_2305 ENOG4105II7 pyrroline-5-carboxylate reductase BF89_2307 ENOG4108J59 Extracellular solute-binding protein, family 5 BF89_2308 ENOG4108J59 Extracellular solute-binding protein, family 5 BF89_2314 ENOG4108JQ7 (ABC) transporter BF89_2315 ENOG4105C3U ABC transporter BF89_2316 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF89_2317 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF89_232 ENOG4108N23 SpoOM-related protein BF89_2320 ENOG4105C2C drug resistance transporter, Bcr CflA BF89_2323 ENOG4105IQ5 FAD linked oxidase domain protein BF89_2324 ENOG4105IQ5 FAD linked oxidase domain protein BF89_2326 ENOG4105EE1 crotonyl-CoA reductase BF89_2327 ENOG4105D01 (LipO)protein BF89_2328 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF89_2329 ENOG4108UMI ABC transporter, permease BF89_2330 ENOG4108PSK reductase BF89_2337 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF89_2338 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF89_2340 ENOG4105CMG Carbohydrate kinase BF89_2342 ENOG4108VQT Alpha beta hydrolase fold protein BF89_2343 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF89_2345 ENOG4107U5W ybbr family BF89_2346 ENOG4105C8B TIGR00159 family BF89_2364 ENOG4108NMV polysaccharide deacetylase BF89_2367 ENOG4105D1F ATP-binding protein BF89_2372 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF89_2373 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF89_2374 ENOG4108JJB ABC transporter BF89_2380 ENOG41067V7 50S ribosomal protein L36 BF89_2382 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF89_2384 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF89_2389 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF89_240 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF89_241 ENOG4108JUB Transcriptional regulator BF89_2410 ENOG4105XPM ribosomal protein BF89_2411 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF89_2413 ENOG4107Y49 methyltransferase BF89_2418 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF89_242 ENOG4108TSC N-acetyltransferase BF89_2420 ENOG4105QIV RNA polymerase BF89_2421 ENOG4105M0M Tetracycline resistance protein BF89_2422 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF89_2425 ENOG4105D7W serine acetyltransferase BF89_2429 ENOG4105CTP PilT protein domain protein BF89_243 ENOG4107S4Y M20 DapE family protein YgeY BF89_2431 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF89_2434 ENOG4108Z0C Uvrb UvrC protein BF89_2441 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF89_2443 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF89_2444 ENOG4105KRF dihydroneopterin aldolase BF89_2445 ENOG4105EEI dihydropteroate synthase BF89_2446 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF89_2447 ENOG4105DDQ anthranilate synthase BF89_2448 ENOG4105CRQ synthase (Component I) BF89_2449 ENOG4105C6T cysteine synthase BF89_2452 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF89_2453 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF89_2454 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF89_2458 ENOG41060GV RNA binding s1 domain protein BF89_246 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF89_2461 ENOG4105VYY sporulation protein yabp BF89_2462 ENOG41082I2 s4 domain protein BF89_2463 ENOG4108IY2 MazG family BF89_2465 ENOG4108M14 stage v sporulation protein t BF89_2466 ENOG4108JA2 transcriptioN-repair coupling factor BF89_2468 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF89_2469 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF89_2472 ENOG4105KME endoribonuclease L-psp BF89_2473 ENOG4105DFT pur operon repressor BF89_2476 ENOG4105W42 Veg protein BF89_2477 ENOG4105XFA sporulation peptidase YabG BF89_2479 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF89_2480 ENOG4105F8V Hydrolase, tatD family BF89_2482 ENOG4105KRN Transcriptional regulator, abrb family BF89_2483 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF89_2485 ENOG41060K3 Methyltransferase BF89_2487 ENOG4105MA4 psp1 domain protein BF89_2488 ENOG4105FA2 dna polymerase iii BF89_2490 ENOG4105CXN decarboxylase BF89_2498 ENOG41067KS pro-sigma K processing BF89_2502 ENOG4105C6E dna polymerase iii BF89_2503 ENOG4108Z6B deaminase BF89_2504 ENOG4105GTG Isochorismatase BF89_2506 ENOG4105ZMH deoxynucleoside kinase BF89_251 ENOG4105C37 (CBS) domain BF89_2513 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF89_2521 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF89_2524 ENOG410848D S4 domain protein YaaA BF89_2525 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF89_2529 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF89_2531 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF89_2535 ENOG4107QJE Chromosome Partitioning Protein BF89_2536 ENOG4105FA0 parb-like partition protein BF89_2537 ENOG4108ZDA Sporulation protein YyaC BF89_2538 ENOG4105D8X mechanosensitive ion channel BF89_2539 ENOG4105VDK protein, conserved in bacteria BF89_2540 ENOG4105C3G gtp-binding protein BF89_2542 ENOG4108UUM single-stranded DNA-binding protein BF89_2544 ENOG4108XMW Membrane BF89_2545 ENOG4105BZR domain protein BF89_2547 ENOG4105CDU Replicative dna helicase BF89_2553 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_2554 ENOG4105BZU Histidine kinase BF89_2557 ENOG4105Q2H domain protein BF89_2558 ENOG4105C0H protease BF89_2562 ENOG4105DPN Oligoendopeptidase f BF89_2565 ENOG4105C1J atp-dependent rna helicase BF89_2567 ENOG4108UT2 hemolysin iii BF89_2568 ENOG4105CMR udp-glucose 4-epimerase BF89_2570 ENOG4105IW1 AmiS UreI transporter BF89_2572 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF89_2575 ENOG4107RGD Major Facilitator superfamily BF89_2576 ENOG4108HRK Histidine kinase BF89_2577 ENOG4105DY9 regulatoR BF89_258 ENOG4105E90 ABC transporter BF89_2580 ENOG4106F5Q Membrane BF89_2581 ENOG4105E0X reductase BF89_2583 ENOG41067SE Tetr family transcriptional regulator BF89_2584 ENOG4105CKK Glycosyl transferase, family 2 BF89_2589 ENOG4105C5H ABC transporter BF89_259 ENOG4108IJ8 ABC transporter BF89_2590 ENOG4105JEU Glycosyl transferase, family 2 BF89_2592 ENOG4108S4H thioesterase Superfamily protein BF89_2594 ENOG4106YBV Methyl-accepting chemotaxis BF89_2595 ENOG4106YBV Methyl-accepting chemotaxis BF89_2596 ENOG4105EN6 Membrane BF89_2600 ENOG41079KZ Major Facilitator Superfamily BF89_2601 ENOG4105DY9 regulatoR BF89_2602 ENOG4105D22 carbon starvation protein BF89_2603 ENOG4105VCD cytoplasmic protein BF89_2604 ENOG4105BZU Histidine kinase BF89_2605 ENOG4105DWF phosphomethylpyrimidine kinase BF89_2606 ENOG4105BZU Histidine kinase BF89_2607 ENOG4105BZU Histidine kinase BF89_2608 ENOG4105WH1 Two component transcriptional regulator luxr family BF89_2610 ENOG4108Y4K DNA-binding transcriptional activator BF89_2615 ENOG4105D6E homoserine dehydrogenase BF89_2618 ENOG41090WU lipolytic protein G-D-S-L family BF89_2619 ENOG4105CJ1 ABC, transporter BF89_2620 ENOG4108TU7 Inherit from COG: (ABC) transporter BF89_2622 ENOG4105VCH membrane BF89_2623 ENOG410667J hydrolase BF89_2625 ENOG4107SVH Potassium channel protein BF89_2629 ENOG4108VKI Cell wall hydrolase BF89_2632 ENOG4108IJ2 phosphate acetyltransferase BF89_2635 ENOG4108VCI transcription factor, rsfa family BF89_2637 ENOG4105DQ5 transport system permease protein BF89_2638 ENOG4105EHG Permease protein BF89_2639 ENOG4105E0A ABC, transporter BF89_2640 ENOG4108MES Periplasmic binding protein BF89_2641 ENOG4105DCI Phosphohydrolase BF89_2642 ENOG41069HH 4-oxalocrotonate tautomerase BF89_2643 ENOG4108Z4T Peptidase M50 BF89_2644 ENOG4108XFG YwhD family BF89_2645 ENOG4105BZ4 penicillin-binding protein BF89_2646 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF89_2647 ENOG4107SWG transcriptional regulator MERR family BF89_2648 ENOG4105DXB Major Facilitator superfamily BF89_265 ENOG4105CMG Carbohydrate kinase BF89_2650 ENOG4105CYW agmatinase BF89_2654 ENOG410684U Domain of unknown function (DUF1934) BF89_2656 ENOG4105EMN RNA polymerase sigma factor BF89_266 ENOG4105CMG Carbohydrate kinase BF89_2660 ENOG4105IIU Aminopeptidase BF89_2663 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF89_2664 ENOG4108M15 ABC transporter BF89_2665 ENOG4105KCT ABC transporter BF89_2666 ENOG4105BZU Histidine kinase BF89_2671 ENOG4105BZU Histidine kinase BF89_2674 ENOG4105DF6 Fe-S oxidoreductase BF89_2676 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF89_2677 ENOG4105C1G acyl-Coa dehydrogenase BF89_2678 ENOG4105C1G acyl-Coa dehydrogenase BF89_2685 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF89_2686 ENOG4105CBT Fructose-1,6-bisphosphatase BF89_2687 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF89_2690 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF89_2691 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF89_2692 ENOG4108ZXQ stage ii sporulation protein r BF89_2694 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF89_2697 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF89_2698 ENOG4108VGI doxx family BF89_27 ENOG4108VXD carboxy-peptidase BF89_2701 ENOG4108YZG isomerase BF89_2706 ENOG41062M3 atp synthase BF89_2707 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF89_2717 ENOG4105BZU Histidine kinase BF89_2718 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF89_2720 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF89_2721 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF89_2726 ENOG4105D65 subunit l BF89_2727 ENOG4105C8S subunit m BF89_2728 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF89_2729 ENOG4106778 Protein of unknown function (DUF1146) BF89_273 ENOG4106KNT transcriptional regulator BF89_2733 ENOG4108IUW ABC transporter BF89_2734 ENOG4105DY9 regulatoR BF89_2737 ENOG4105FRN stage II sporulation protein BF89_2739 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF89_2749 ENOG4105EY8 ABC transporter BF89_275 ENOG4105WH1 Two component transcriptional regulator luxr family BF89_2750 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF89_2753 ENOG4105CMR udp-glucose 4-epimerase BF89_2754 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_2755 ENOG4105BZU Histidine kinase BF89_2758 ENOG4105CXY transporter BF89_276 ENOG4105BZU Histidine kinase BF89_2762 ENOG4105C19 ABC transporter BF89_2763 ENOG4107RBB ABC transporter, permease BF89_2765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_277 ENOG4105D8X mechanosensitive ion channel BF89_2771 ENOG4105C0D helicase BF89_2772 ENOG4105KBK Zinc finger, swim domain protein BF89_2777 ENOG41069ER domain protein BF89_2778 ENOG4105C94 Transporter BF89_2780 ENOG4107R8N Glycosyl transferase, family 2 BF89_2786 ENOG4105E0M Sulfatase BF89_2789 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF89_2791 ENOG4105DAA L-lactate BF89_2799 ENOG4107RSM transcriptional regulator BF89_2800 ENOG4105ECB domain protein BF89_2801 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_2804 ENOG4105VZJ PTS System BF89_2806 ENOG4105VCP PTS System BF89_2807 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF89_2808 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF89_2810 ENOG4105CK1 PTS System BF89_2811 ENOG4105VCP PTS System BF89_2812 ENOG4105F8D glycoside hydrolase family 4 BF89_2813 ENOG410901P UPF0249 protein BF89_2816 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF89_2818 ENOG4105ESV Glycosyl transferase, family 4 BF89_2819 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF89_2820 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF89_2821 ENOG4108KGH TRANSCRIPTIONal BF89_2822 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF89_2824 ENOG4105KVH Transcriptional regulator BF89_2828 ENOG41081UC Inherit from COG: Competence protein BF89_2829 ENOG4105VEQ Cold shock protein BF89_2830 ENOG4105MS2 ribosomal subunit Interface protein BF89_2831 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF89_2832 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF89_2834 ENOG4105CAK Cell division ATP-binding protein ftsE BF89_2835 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF89_2836 ENOG4105CN1 protease BF89_2838 ENOG4105BZ1 (ABC) transporter BF89_284 ENOG4105F0I Aminotransferase BF89_2841 ENOG4108WS4 fmn reductase BF89_2843 ENOG4105DUM transcriptional regulator, lysR family BF89_2844 ENOG4105HMI Membrane BF89_2848 ENOG4107TXC Transcriptional regulator BF89_285 ENOG4108MES Periplasmic binding protein BF89_2851 ENOG4105D7V transposase BF89_2852 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF89_2853 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF89_2855 ENOG41086DT Membrane protein of unknown function BF89_2859 ENOG4108S4C acetyltransferase BF89_2861 ENOG4105C3M thioredoxin reductase BF89_2863 ENOG4108Z4K mutator MutT protein BF89_2865 ENOG4105CHW UPF0052 protein BF89_2867 ENOG4105KRI phosphocarrier protein (HPr BF89_2868 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF89_2869 ENOG4105H67 Protein of unknown function (DUF421) BF89_2872 ENOG4105CZ3 stage V sporulation protein ad BF89_2873 ENOG41090VF Stage v sporulation protein ac BF89_2877 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_288 ENOG4105CAQ asparagine synthetase BF89_2882 ENOG4105CP7 Triose-phosphate isomerase BF89_2883 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF89_2885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF89_2889 ENOG4105EFC phage portal protein HK97 family BF89_289 ENOG4107Y70 Heat shock protein BF89_290 ENOG4108KF3 Electron transport protein SCO1 SenC BF89_2908 ENOG41067MG lrgb family BF89_2909 ENOG4105XZU Preprotein translocase, subunit SecG BF89_291 ENOG4105E8R UPF0173 metal-dependent hydrolase BF89_2911 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF89_2916 ENOG4105CM4 permease protein BF89_2917 ENOG4108IPW abc transporter atp-binding protein BF89_292 ENOG4108RCR degv family BF89_2920 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF89_2921 ENOG4108MK9 spermidine N(1)-acetyltransferase BF89_2924 ENOG4105WMR Protein CrcB homolog BF89_2925 ENOG4105WMR Protein CrcB homolog BF89_2927 ENOG4105C8Q Methyl-accepting chemotaxis BF89_2929 ENOG4105D4A Cell wall formation (By similarity) BF89_2930 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF89_2933 ENOG4105KVH Transcriptional regulator BF89_2934 ENOG4105F27 Major Facilitator BF89_2935 ENOG4105CV8 reductase BF89_294 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF89_2940 ENOG4108RYK Nad-dependent epimerase dehydratase BF89_2943 ENOG4105D9N nucleoside BF89_2944 ENOG4105D9N nucleoside BF89_2949 ENOG4108URH decarboxylase BF89_2952 ENOG4108RMU ferritin dps family protein BF89_2954 ENOG4105NCW Trka-c domain protein BF89_2955 ENOG4107S91 Sodium hydrogen exchanger BF89_2959 ENOG4105D4Y metalloprotease BF89_296 ENOG4108UT2 hemolysin iii BF89_2960 ENOG4105VG1 fes assembly suf system protein BF89_2963 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF89_2965 ENOG4105BZU Histidine kinase BF89_2966 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_2967 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF89_2969 ENOG4107ZTW SNARE associated Golgi BF89_297 ENOG4105E9Q Acyl-transferase BF89_2976 ENOG4107AYK membrAne BF89_2978 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF89_298 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF89_2980 ENOG4107R7I amino acid BF89_2981 ENOG4108SUT Major Facilitator Superfamily BF89_2985 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF89_2989 ENOG4105DZ1 carboxypeptidase BF89_299 ENOG4107RVG penicillin-binding protein BF89_2992 ENOG4105CHU acetyl-coa acetyltransferase BF89_2993 ENOG4105C1G acyl-Coa dehydrogenase BF89_2994 ENOG4108W8B Beta-lactamase domain protein BF89_3 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF89_30 ENOG4105VZ8 Transcriptional regulator BF89_3000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF89_3009 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF89_3015 ENOG4108UMI ABC transporter, permease BF89_3016 ENOG4105D01 (LipO)protein BF89_3017 ENOG4105D01 (LipO)protein BF89_3018 ENOG4105C3K feS assembly ATPase SufC BF89_3019 ENOG4105JRK feS assembly protein SufD BF89_302 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF89_3020 ENOG4105C9B Cysteine desulfurase BF89_3021 ENOG4108UNV SUF system FeS assembly protein, NifU family BF89_3022 ENOG4105DIW FeS assembly protein SUFB BF89_3025 ENOG4107R8B 5'-nucleotidase BF89_3026 ENOG4105KZD Domain of unknown function (DUF1805) BF89_3028 ENOG4105FAA peptidase M23 BF89_3033 ENOG41090T1 Membrane BF89_3034 ENOG4107TXC Transcriptional regulator BF89_3035 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF89_3036 ENOG4105MMD transcriptional regulator BF89_3039 ENOG4105CBT Fructose-1,6-bisphosphatase BF89_3042 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF89_3043 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF89_3045 ENOG4108W5N phosphatidylglycerophosphatase a BF89_3048 ENOG41083MR nifu domain-containing protein BF89_3057 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF89_3058 ENOG4105C4B ABC transporter, permease BF89_3059 ENOG4108JJA ABC, transporter BF89_306 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF89_3063 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF89_3066 ENOG4105EWC Purine nucleoside phosphorylase BF89_3072 ENOG4105CEP NADH dehydrogenase BF89_3075 ENOG41069ER domain protein BF89_3079 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF89_3083 ENOG4105KA0 thioesterase Superfamily protein BF89_3084 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF89_3087 ENOG4107R3E Citrate transporter BF89_3089 ENOG4105Y38 Kinase-associated protein B BF89_3092 ENOG4105C87 Aminotransferase class I and II BF89_3094 ENOG4108MUZ hydrolase BF89_3095 ENOG4105C5I Dehydrogenase BF89_3096 ENOG4108ZB6 transcriptional regulator AsnC family BF89_3097 ENOG4105CHM Aminotransferase BF89_3099 ENOG4105WG9 Conserved Protein BF89_3100 ENOG4107QYV phosphohexose isomerase BF89_3101 ENOG4107PBV potassium channel BF89_3103 ENOG4105KT7 mgtC SapB transporter BF89_311 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF89_3111 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF89_313 ENOG4105KD7 acetyltransferase BF89_3130 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF89_3132 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF89_3134 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF89_3139 ENOG4105VEQ Cold shock protein BF89_3141 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF89_3142 ENOG4105E4F Isochorismate synthase BF89_3143 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF89_3144 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF89_3145 ENOG4108IPT Naphthoate synthase BF89_3147 ENOG4105DTQ mandelate racemase muconate lactonizing BF89_3153 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF89_3157 ENOG4105FDP GntR family transcriptional regulator BF89_3158 ENOG4105C6Z Gluconate BF89_316 ENOG4105C0A alcohol dehydrogenase BF89_3167 ENOG41086D8 Transcriptional regulator BF89_3168 ENOG4105C19 ABC transporter BF89_317 ENOG4105CY2 Citrate transporter BF89_3171 ENOG4107ZTW SNARE associated Golgi BF89_3178 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF89_3179 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF89_318 ENOG4107XGZ Hydrolase BF89_3184 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_3185 ENOG4105BZU Histidine kinase BF89_3192 ENOG41087YS Phage shock protein A BF89_3201 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF89_3202 ENOG4105C4M (Ubiquinol oxidase) subunit I BF89_3204 ENOG4108V2W Carbonate dehydratase BF89_3211 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF89_3215 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF89_3217 ENOG4105D2X ABC transporter substrate-binding protein BF89_322 ENOG4105C8J )-transporter BF89_3221 ENOG4107T7U Sulfatase BF89_3222 ENOG4107S9D Alpha beta hydrolase BF89_3223 ENOG4105BZU Histidine kinase BF89_3224 ENOG4105BZU Histidine kinase BF89_3225 ENOG4105EGD dinuclear metal center protein, YbgI family BF89_3235 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF89_3237 ENOG4105BZF Glycosyl transferase (Group 1 BF89_3238 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF89_3239 ENOG4108Z0R Transferase BF89_3240 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF89_3246 ENOG4105DA5 (ABC) transporter BF89_3248 ENOG4105N5T Radical SAM Protein BF89_325 ENOG41062D9 Histidine kinase BF89_3252 ENOG4105C19 ABC transporter BF89_3255 ENOG4105NCW Trka-c domain protein BF89_3256 ENOG4107S91 Sodium hydrogen exchanger BF89_3257 ENOG410605W Major Facilitator BF89_326 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_3263 ENOG4108B31 Spore germination protein BF89_3266 ENOG4105DWV Homoserine O-trans-acetylase BF89_3268 ENOG41085GJ domain protein BF89_327 ENOG4107QPK )-transporter BF89_3272 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF89_3273 ENOG4105D06 uba thif-type nad fad binding protein BF89_3275 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF89_3276 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF89_3277 ENOG4108ZAF Molybdopterin BF89_328 ENOG4105BZW Glycerate kinase BF89_3280 ENOG4105CSC Glucose uptake protein BF89_3281 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF89_3282 ENOG4108VJ1 Transcriptional regulator (CarD family BF89_3289 ENOG4105CBX hi0933 family BF89_3292 ENOG4105YW5 deoR family transcriptional regulator BF89_3293 ENOG4107QSE Dipeptidase BF89_3295 ENOG4108IUM Glycogen debranching enzyme BF89_3296 ENOG4108V15 phosphotransferase enzyme family BF89_3299 ENOG4105C8F Beta-lactamase domain protein BF89_33 ENOG4105CGH 5'-nucleotidase BF89_3305 ENOG4108VDD TRNA binding domain protein BF89_3314 ENOG4105C88 aminopeptidase BF89_3318 ENOG4105ETE Transcriptional regulator (LacI family BF89_3324 ENOG4105EP9 oxidoreductase BF89_3325 ENOG4107SNB ankyrin repeat protein YahD BF89_3327 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_3329 ENOG4105DGU Histone deacetylase BF89_3330 ENOG4105W87 Cbs domain BF89_3331 ENOG4105F1V Acetoin utilization protein BF89_3334 ENOG4105EMN RNA polymerase sigma factor BF89_3336 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF89_3340 ENOG4105C28 cystathionine BF89_3342 ENOG4105U5Y Transcriptional regulator BF89_3343 ENOG4105U5Y Transcriptional regulator BF89_3345 ENOG4106KR7 LysR family Transcriptional regulator BF89_3350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF89_3352 ENOG4105EFZ amidohydrolase BF89_3355 ENOG4105KBJ sporulation protein ytfj BF89_3356 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF89_3358 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF89_3362 ENOG4108JYZ YitT family BF89_3370 ENOG4107YZX Universal stress protein BF89_3374 ENOG4105VZ8 Transcriptional regulator BF89_3376 ENOG41082W1 Cupin 2, conserved barrel domain protein BF89_3377 ENOG4105Z7P Acetyltransferase (GNAT) family BF89_3384 ENOG4105DC7 peptidase M24 BF89_3391 ENOG4105SFS phosphoesterase RecJ domain protein BF89_3393 ENOG4105VV2 BF89_3394 ENOG4105C0B DNA polymerase III (alpha subunit) BF89_3395 ENOG4105C6K Malic enzyme BF89_3396 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF89_3401 ENOG4105FS0 cytoplasmic membrane protein BF89_3402 ENOG4108REF Sporulation integral membrane protein ytvi BF89_3404 ENOG4105BZN citrate synthase BF89_3405 ENOG4108HMX isocitrate dehydrogenase (NADP) BF89_3409 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_3410 ENOG4105BZU Histidine kinase BF89_3411 ENOG4105C2M dna polymerase I BF89_3412 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF89_3414 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF89_3415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF89_3416 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF89_3420 ENOG4108TDW sporulation protein YtxC BF89_3421 ENOG4105C22 threonyL-tRNA synthetase BF89_3422 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF89_3426 ENOG4105CN9 Peptidase m42 family protein BF89_3427 ENOG4108JGH Tetr family transcriptional regulator BF89_3428 ENOG4105CW7 secretion protein, HlyD family BF89_3429 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_3436 ENOG4108RWN rrna methyltransferase BF89_3438 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF89_3439 ENOG4105C5S asparaginyl-tRNA synthetase BF89_3446 ENOG4105DCG PHP domain protein BF89_3449 ENOG4105FE9 pseudouridine synthase BF89_3451 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF89_3453 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF89_3456 ENOG4105E0A ABC, transporter BF89_3457 ENOG4105KFN sortase, SrtB family BF89_346 ENOG4105EC2 ftsk spoIIIe BF89_3460 ENOG4105DR4 Methyltransferase BF89_3463 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_3472 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF89_3473 ENOG4105J76 Periplasmic binding protein BF89_3475 ENOG4105CEY Amp-dependent synthetase and ligase BF89_3476 ENOG4107Z3H Transcriptional regulator, TetR family BF89_3477 ENOG41060WC Enoyl-CoA hydratase BF89_3478 ENOG4105BZJ Electron transfer flavoprotein BF89_3479 ENOG4105C10 Electron transfer flavoprotein BF89_3480 ENOG4105K63 Thioredoxin BF89_3483 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF89_3485 ENOG4105E33 succinate dehydrogenase BF89_3487 ENOG4108VXD carboxy-peptidase BF89_3488 ENOG4105E14 MotA TolQ exbB proton channel BF89_3489 ENOG4105ER2 Ompa motb domain protein BF89_3490 ENOG4105ER2 Ompa motb domain protein BF89_3491 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF89_3492 ENOG4108IUX (ABC) transporter BF89_3493 ENOG4105RHA ABC transporter, permease BF89_3494 ENOG4108Z40 Transcriptional regulator BF89_3495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF89_3497 ENOG4108JCI Transcriptional regulator BF89_3498 ENOG41067S9 phage shock protein C, PspC BF89_350 ENOG4105C5S asparaginyl-tRNA synthetase BF89_3501 ENOG4105DY9 regulatoR BF89_3502 ENOG4108HRK Histidine kinase BF89_3503 ENOG4108JQ7 (ABC) transporter BF89_3506 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF89_3507 ENOG4105DEF Extracellular solute-binding protein, family 5 BF89_3508 ENOG4105DZC cytosine deaminase BF89_3509 ENOG4105DZC cytosine deaminase BF89_351 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF89_3512 ENOG4105PFC Transcriptional regulator BF89_3515 ENOG4105KBX Transcriptional regulator, TetR family BF89_3517 ENOG4108PCX Major Facilitator BF89_3519 ENOG4108XJQ germination protein BF89_3521 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF89_3522 ENOG4105M59 Phosphodiesterase, mj0936 family BF89_3526 ENOG4108QCI YvbH-like oligomerisation region BF89_3532 ENOG4108IUQ atp-dependent protease BF89_3536 ENOG4105K56 Transcriptional regulator BF89_354 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF89_3541 ENOG4105D52 delta-aminolevulinic acid dehydratase BF89_3543 ENOG41068KH stage VI sporulation protein D BF89_3545 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF89_3546 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF89_3550 ENOG4105DFF Rod shape-determining protein mreb BF89_3551 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF89_3554 ENOG4107QMS site-determining protein BF89_3557 ENOG4105C03 ribonuclease BF89_3559 ENOG4105X36 (ribosomal) protein BF89_3562 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF89_3565 ENOG4105EWM Histidine kinase BF89_3569 ENOG4105CQC Prephenate dehydratase BF89_3570 ENOG4108RPX mosc domain containing protein BF89_3573 ENOG4108IYU L-aspartate oxidase BF89_3574 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF89_3579 ENOG41082BM Transcriptional regulator, arsr family BF89_3580 ENOG4108IPJ Membrane BF89_3581 ENOG4108IPJ Membrane BF89_3583 ENOG4108HUF Transporter BF89_3586 ENOG41061AI Protein of unknown function (DUF2905) BF89_3589 ENOG4105VIE preprotein translocase, subunit YajC BF89_3591 ENOG4108QG2 Membrane BF89_3592 ENOG4105CKP Polysaccharide Biosynthesis Protein BF89_3594 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF89_3595 ENOG41076HS cation diffusion facilitator family transporter BF89_3596 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF89_3598 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF89_360 ENOG4105C75 arginyL-tRNA synthetase BF89_3601 ENOG4105CUT histidyl-tRNA synthetase BF89_3603 ENOG4105CUZ uba thif-type nad fad binding protein BF89_3604 ENOG4108VCI transcription factor, rsfa family BF89_3605 ENOG4105D1H recombination factor protein RarA BF89_3607 ENOG4105C3J Cysteine desulfurase BF89_3608 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF89_361 ENOG4107YX5 Pfam:DUF548 BF89_3610 ENOG4105C7H Helicase, RecD TraA family BF89_3611 ENOG41060CR BF89_3614 ENOG4105C02 permease BF89_3616 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF89_3620 ENOG4105HHA aminodeoxychorismate lyase BF89_3621 ENOG4108VQJ O-methyltransferase BF89_3622 ENOG4105XYU peptidase (U32 family) BF89_3623 ENOG4105CFP Peptidase U32 BF89_3626 ENOG4107XRG penicillin-binding protein BF89_3632 ENOG4105C28 cystathionine BF89_3633 ENOG4108EKI Dehydrogenase BF89_3635 ENOG4108V5C ABC transporter BF89_3636 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF89_3644 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_3646 ENOG4105MIR Phenylalanine 4-monooxygenase BF89_3647 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF89_365 ENOG41061H0 Monooxygenase BF89_3654 ENOG4108MUZ hydrolase BF89_3656 ENOG4105G6Z alkaline phosphatase BF89_3659 ENOG4108TVJ Nitroreductase BF89_3663 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_3665 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF89_3666 ENOG4105CQW ribosome biogenesis GTPase YqeH BF89_3668 ENOG410812S Rna-binding protein BF89_367 ENOG4108UUM single-stranded DNA-binding protein BF89_3670 ENOG4108WF2 Metal Dependent Phosphohydrolase BF89_3672 ENOG4105DXX methyltransferase BF89_3674 ENOG4105KQC Competence protein BF89_3675 ENOG4108UK2 deaminase BF89_3676 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF89_3678 ENOG4105TQK DNA polymerase iii, delta' subunit BF89_3683 ENOG4105KVH Transcriptional regulator BF89_3684 ENOG4105CSA Coproporphyrinogen iii oxidase BF89_3686 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF89_3690 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF89_3691 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF89_3693 ENOG4105KTH gatB Yqey BF89_3694 ENOG41068P3 sporulation protein YqfC BF89_3696 ENOG4105C9A Phoh family BF89_3697 ENOG4105CTJ Metal Dependent Phosphohydrolase BF89_3699 ENOG4107YR5 Diacylglycerol kinase BF89_370 ENOG4105C5H ABC transporter BF89_3700 ENOG4105KG3 cytidine deaminase BF89_3701 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF89_3706 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF89_3707 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_3710 ENOG4105EGD dinuclear metal center protein, YbgI family BF89_3715 ENOG41069ZM Protein of unknown function (DUF2624) BF89_3716 ENOG4108JYZ YitT family BF89_3717 ENOG4105FDK ABC transporter BF89_3719 ENOG4105N80 Ferric uptake regulator, Fur family BF89_3724 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF89_3726 ENOG4107RF6 penicillin-binding protein BF89_3727 ENOG4105PWN phosphate abc transporter BF89_3728 ENOG4105C8U phosphate abc transporter BF89_3729 ENOG4105E2Z phosphate ABC transporter (Permease BF89_3730 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF89_3731 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF89_3734 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF89_3736 ENOG4105DKQ ROK family BF89_3738 ENOG4105C5X domain protein BF89_374 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF89_3742 ENOG4105C28 cystathionine BF89_3743 ENOG4105C28 cystathionine BF89_3746 ENOG4105C3R Methionine synthase BF89_3747 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF89_3759 ENOG4106855 Competence protein BF89_377 ENOG4105MCT stage V sporulation protein S BF89_3771 ENOG4105C0D helicase BF89_3777 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF89_3778 ENOG4105CJ1 ABC, transporter BF89_3785 ENOG41080TC multidrug resistance protein BF89_3789 ENOG4105WZW rhodanese family BF89_3790 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF89_3795 ENOG4107YBY Hydrolase BF89_3796 ENOG4105CBJ Metal-dependent enzyme BF89_3799 ENOG4105DC7 peptidase M24 BF89_38 ENOG4105D2N Aldolase BF89_3804 ENOG4105CD2 stage iii sporulation protein aa BF89_3805 ENOG4105KR5 Stage iii sporulation protein BF89_3806 ENOG4108CQH stage III sporulation protein AC BF89_3807 ENOG4105KQ4 Stage iii sporulation protein ad BF89_3809 ENOG410644B Stage III sporulation protein af BF89_3814 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF89_3815 ENOG4108ZSR alkaline shock protein BF89_3820 ENOG4105CTB Polyprenyl synthetase BF89_3822 ENOG4105DX0 Hemolysin A BF89_3824 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF89_3825 ENOG4105S1Z Stage IV sporulation protein B BF89_3826 ENOG4107QQR Sporulation BF89_3829 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF89_3831 ENOG4108JUB Transcriptional regulator BF89_3833 ENOG4107RDP Dehydrogenase BF89_3837 ENOG4105CPP Dehydrogenase, E1 component BF89_3838 ENOG4105C7S Dehydrogenase BF89_3840 ENOG4105E09 nadh pyrophosphatase BF89_3841 ENOG4105G7B Protein of unknown function (DUF2992) BF89_3843 ENOG4108HW3 (ABC) transporter BF89_3844 ENOG4105E5Q amino acid AbC transporter BF89_3845 ENOG4105CDA abc transporter atp-binding protein BF89_3846 ENOG4108QEG Membrane BF89_3847 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF89_3849 ENOG4105D9U N-acetyltransferase BF89_385 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF89_3850 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF89_3852 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF89_3856 ENOG4105EJQ L-serine dehydratase BF89_3857 ENOG4105II7 pyrroline-5-carboxylate reductase BF89_3858 ENOG41069FQ Metallo-beta-lactamase superfamily BF89_3859 ENOG4108IXY short-chain dehydrogenase reductase BF89_386 ENOG4108IFG nitrite reductase, (NAD(P)H) BF89_3862 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF89_387 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF89_3870 ENOG4105CGH 5'-nucleotidase BF89_3871 ENOG4105DFD Na H antiporter BF89_3873 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF89_3875 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF89_3876 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF89_3877 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF89_3878 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF89_388 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF89_3882 ENOG4108R6K riboflavin synthase, subunit alpha BF89_3883 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF89_3887 ENOG4108YM7 Gcn5-related n-acetyltransferase BF89_3888 ENOG4105ETE Transcriptional regulator (LacI family BF89_389 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF89_3890 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF89_3894 ENOG4105RHY Pfam:UPF0157 BF89_3896 ENOG4105CPC Aldo Keto reductase BF89_390 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF89_3900 ENOG4105MZ9 stage II sporulation protein m BF89_3901 ENOG4105I3K Ferric uptake regulator, Fur family BF89_3903 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF89_3908 ENOG4105D7N magnesium and cobalt transport protein CorA BF89_3914 ENOG4105DVE abc transporter atp-binding protein BF89_3915 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF89_3916 ENOG4105DZ1 carboxypeptidase BF89_3917 ENOG41082AN stage II sporulation protein BF89_3919 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_3920 ENOG4105C8J )-transporter BF89_3924 ENOG41090VF Stage v sporulation protein ac BF89_3925 ENOG4105CZ3 stage V sporulation protein ad BF89_3927 ENOG4105G6R Stage v sporulation protein ae BF89_3929 ENOG4105J7I hydrolase BF89_3930 ENOG4105PTM secreted protein BF89_3931 ENOG4107ZE5 PPIases accelerate the folding of proteins BF89_3938 ENOG4105CE4 GlcNAc 6-P deacetylase BF89_3940 ENOG4105FDP GntR family transcriptional regulator BF89_3942 ENOG4105CID antiterminator BF89_3945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF89_3949 ENOG4106TD9 Diguanylate cyclase BF89_395 ENOG4108ZAF Molybdopterin BF89_3950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF89_3951 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF89_3954 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF89_3959 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF89_396 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF89_3961 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF89_3963 ENOG4105DTD Dehydrogenase BF89_3964 ENOG4105K7K Transcriptional regulator BF89_397 ENOG4105D06 uba thif-type nad fad binding protein BF89_3971 ENOG4105CHU acetyl-coa acetyltransferase BF89_398 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF89_3980 ENOG4105CG3 alpha amylase, catalytic region BF89_3982 ENOG4107FKK extracellular solute-binding protein family 1 BF89_3984 ENOG4105EG2 ABC transporter, permease BF89_3985 ENOG4105FKQ transcriptional regulator BF89_3986 ENOG4105CHM Aminotransferase BF89_3988 ENOG4108HGU Histidine kinase BF89_399 ENOG4107V6Q Cyclic nucleotide-binding domain BF89_3999 ENOG4105UIN BF89_4 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF89_4001 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF89_4002 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF89_4005 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF89_4006 ENOG4105EPM Diguanylate phosphodiesterase BF89_4009 ENOG4107IN1 Protein of unknown function (DUF1797) BF89_4011 ENOG4108XRC Protein of unknown function (DUF458) BF89_4018 ENOG4107ZYR domain protein BF89_4019 ENOG4105CN5 Metallo-Beta-Lactamase BF89_4021 ENOG4108X4Q Hydrolase BF89_4022 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF89_4025 ENOG4105CPP Dehydrogenase, E1 component BF89_4035 ENOG4105CXN decarboxylase BF89_4039 ENOG4105ECY inositol monophosphatase BF89_404 ENOG4105R3A Nitrate reductase BF89_4041 ENOG4105CI3 gtp-binding protein typa BF89_4042 ENOG4105QA2 BF89_4046 ENOG4108IAB Phoh family BF89_4049 ENOG4105CNI cell division protein FtsW BF89_405 ENOG4108IUE nitrate reductase beta subunit BF89_4050 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF89_4060 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF89_4063 ENOG4107TB6 phosphoglycerate mutase BF89_4068 ENOG4106H78 methyltransferase BF89_4069 ENOG4105H20 Sporulation integral membrane protein YlbJ BF89_4071 ENOG4105D78 K07001 NTE family protein BF89_4072 ENOG41063PX domain protein BF89_4074 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF89_4082 ENOG4108IMY Transcriptional regulator BF89_409 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF89_4092 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_4096 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF89_4113 ENOG4105CAR Terminase, large subunit BF89_4115 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF89_412 ENOG4108V06 Glutathione peroxidase BF89_4132 ENOG4105XSJ toxin secretion phage lysis holin BF89_4143 ENOG4105KNH Nucleic acid-binding protein BF89_4150 ENOG41068DC Essential cell division protein (By similarity) BF89_4151 ENOG4105CJN penicillin-binding protein BF89_4152 ENOG4105CJN penicillin-binding protein BF89_4153 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF89_4156 ENOG4105CNI cell division protein FtsW BF89_4157 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF89_4158 ENOG4105D4A Cell wall formation (By similarity) BF89_4159 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF89_4160 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF89_4161 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF89_4163 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF89_4165 ENOG4105WR5 sporulation protein, YlmC YmxH family BF89_4166 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF89_4167 ENOG4105DFA alanine racemase domain protein BF89_4169 ENOG41067XK integral membrane protein BF89_417 ENOG4105EMN RNA polymerase sigma factor BF89_4170 ENOG4105DBK s4 domain protein BF89_4172 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF89_4175 ENOG4105C34 Pseudouridine synthase BF89_418 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF89_4180 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF89_4191 ENOG4105DC7 peptidase M24 BF89_4192 ENOG4105F23 Fibronectin-binding protein BF89_4194 ENOG4105DSJ YicC domain protein BF89_4198 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF89_4199 ENOG4105C25 Primosomal protein n' BF89_420 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_4200 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF89_4202 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF89_4204 ENOG4108ZF3 Phosphatase BF89_4205 ENOG4105D9P serine threonine protein kinase BF89_4206 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF89_4207 ENOG4105DJV ribulose-phosphate 3-epimerase BF89_4208 ENOG4105FJ0 thiamine BF89_421 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF89_4210 ENOG4108ZAA Alkaline-shock protein BF89_4211 ENOG4105DP4 dak2 domain fusion protein ylov BF89_4212 ENOG4105CB5 ATP-dependent DNA helicase recG BF89_4215 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF89_4216 ENOG4105CHR reductase BF89_4219 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF89_4220 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF89_4224 ENOG4105VB6 UPF0109 protein BF89_4229 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF89_4232 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF89_4235 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF89_4237 ENOG4108HE4 integrase family BF89_4246 ENOG4105KNE Phosphatidate cytidylyltransferase BF89_4247 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF89_4248 ENOG4105DZP Membrane-associated zinc metalloprotease BF89_4250 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF89_4252 ENOG4105CHV Transcription elongation factor NusA BF89_4253 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF89_4254 ENOG4105VHM ribosomal protein BF89_4256 ENOG4105W7A Protein of unknown function (DUF503) BF89_4258 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF89_4259 ENOG4105DTN riboflavin biosynthesis protein ribF BF89_426 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF89_4263 ENOG4105C1V Peptidase, M16 BF89_4265 ENOG4105E35 Dipicolinate synthase subunit A BF89_4266 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF89_4267 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF89_4269 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF89_4271 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF89_4273 ENOG4107QZI cell division protein FtsK BF89_4274 ENOG4105FDP GntR family transcriptional regulator BF89_4275 ENOG4105DIH basic membrane BF89_4276 ENOG4108JQ9 ABC transporter BF89_4277 ENOG4105UIB (ABC) transporter BF89_4278 ENOG4105UIB (ABC) transporter BF89_4282 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF89_4283 ENOG4105XZV Protein of unknown function (DUF3243) BF89_4286 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF89_4291 ENOG4105D48 metallophosphoesterase BF89_4292 ENOG4105MCT stage V sporulation protein S BF89_4293 ENOG4108IGT Dipeptidase BF89_4294 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF89_4295 ENOG4105DQU oxidoreductase, subunit beta BF89_4296 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF89_4301 ENOG4105DA5 (ABC) transporter BF89_4306 ENOG4107QHE Choloylglycine hydrolase BF89_4308 ENOG410890F Dynamin family BF89_4309 ENOG4105E0M Sulfatase BF89_431 ENOG4105KBJ sporulation protein ytfj BF89_4310 ENOG4107R6R udp-galactopyranose mutase BF89_4311 ENOG4105F0V Cell wall hydrolase BF89_4315 ENOG4107YEI lmbE family BF89_4316 ENOG4107TTQ Alpha beta hydrolase fold BF89_4319 ENOG41067MG lrgb family BF89_4322 ENOG4105BZU Histidine kinase BF89_4323 ENOG4105BZU Histidine kinase BF89_4324 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_4330 ENOG4105D03 DNA-3-methyladenine glycosylase II BF89_4331 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF89_4333 ENOG4105CGK Exodeoxyribonuclease III BF89_4334 ENOG4105CGK Exodeoxyribonuclease III BF89_4339 ENOG4105E0A ABC, transporter BF89_4340 ENOG4105NIV Esterase BF89_4342 ENOG4105VPX protein, conserved in bacteria BF89_4343 ENOG410681U heavy metal transport detoxification protein BF89_4344 ENOG4105C59 p-type ATPase BF89_4345 ENOG4105K70 DNA-binding protein BF89_4346 ENOG4105TMB Formate nitrite transporter BF89_4350 ENOG4105C85 amino acid BF89_4353 ENOG4108SJC Membrane BF89_4354 ENOG4107QW4 alcohol dehydrogenase BF89_4355 ENOG4107QW4 alcohol dehydrogenase BF89_4356 ENOG4105E98 transcriptional regulator DeoR family BF89_4357 ENOG4105DE4 1-phosphofructokinase BF89_4358 ENOG4105DM4 PTS System BF89_4359 ENOG41069ER domain protein BF89_4365 ENOG4106F1P AAA ATPase, central domain protein BF89_4367 ENOG4105EN6 Membrane BF89_4368 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF89_4369 ENOG4105CXI aluminum resistance protein BF89_4370 ENOG4105KV4 Transcriptional regulator BF89_4371 ENOG4105C5F glutamine synthetase BF89_4392 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF89_44 ENOG4105CK5 oxidoreductase BF89_440 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF89_4431 ENOG4105XSJ toxin secretion phage lysis holin BF89_4432 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF89_4440 ENOG4105K7K Transcriptional regulator BF89_4444 ENOG4108SVB resolvase BF89_4446 ENOG4105CGH 5'-nucleotidase BF89_4449 ENOG4105D5T phosphonate abc transporter BF89_4452 ENOG4105D7V transposase BF89_4456 ENOG4105BZ1 (ABC) transporter BF89_4457 ENOG4105BZ1 (ABC) transporter BF89_446 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF89_4460 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF89_4466 ENOG41067MG lrgb family BF89_4467 ENOG4105VAW lrga family BF89_4468 ENOG4107RSM transcriptional regulator BF89_447 ENOG4108JYZ YitT family BF89_4470 ENOG4107QIV Cytochrome c biogenesis protein BF89_448 ENOG41087PP glycosyltransferase MGT family BF89_4481 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF89_4486 ENOG4108903 Formimidoylglutamase BF89_4487 ENOG4108VJ1 Transcriptional regulator (CarD family BF89_4488 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF89_4489 ENOG4105CBC glutamate synthase BF89_4490 ENOG4105CK7 Sodium proline symporter BF89_4491 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF89_4492 ENOG4105FBA Phospholipase Carboxylesterase BF89_4493 ENOG4105BZU Histidine kinase BF89_4495 ENOG4107AYK membrAne BF89_45 ENOG4105IE8 Alpha-ketoglutarate permease BF89_4504 ENOG4105CEY Amp-dependent synthetase and ligase BF89_4505 ENOG4107ZYJ bioY protein BF89_4506 ENOG4107F3J Amp-dependent synthetase and ligase BF89_451 ENOG4107RBS Methyltransferase BF89_4510 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF89_4512 ENOG4105E5W Transporter BF89_4517 ENOG4108I0Z Aconitate hydratase BF89_4518 ENOG4108JJA ABC, transporter BF89_452 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF89_4520 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF89_4521 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF89_4527 ENOG4105W8X HesB YadR YfhF-family protein BF89_4528 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF89_4529 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF89_4531 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_4532 ENOG4105C0H protease BF89_4533 ENOG4105K4P CoA-binding domain protein BF89_4534 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF89_4536 ENOG4105D9R oxidoreductase BF89_4538 ENOG4105CIG ABC transporter BF89_454 ENOG4108X4Q Hydrolase BF89_4542 ENOG4105EMN RNA polymerase sigma factor BF89_4544 ENOG4108KGH TRANSCRIPTIONal BF89_4545 ENOG4107QJT sodium dicarboxylate symporter BF89_4556 ENOG4105E1K spore germination protein BF89_4558 ENOG4108JB9 formate dehydrogenase BF89_4559 ENOG4108JB9 formate dehydrogenase BF89_4561 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF89_4562 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF89_4564 ENOG4105TMB Formate nitrite transporter BF89_4565 ENOG4105D06 uba thif-type nad fad binding protein BF89_4566 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF89_4567 ENOG4108ZAF Molybdopterin BF89_4569 ENOG4105D1F ATP-binding protein BF89_4572 ENOG410696E Membrane BF89_4573 ENOG4105FR1 rard protein BF89_4575 ENOG4105EWU Squalene--hopene cyclase BF89_4577 ENOG4105CHR reductase BF89_4578 ENOG4105C26 Dehydrogenase BF89_4580 ENOG4108IA2 Sodium pantothenate symporter BF89_4584 ENOG4106IQC argininosuccinate lyase BF89_4586 ENOG410904N short-chain dehydrogenase reductase BF89_459 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF89_4590 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF89_4594 ENOG4105VEQ Cold shock protein BF89_4598 ENOG4108R1P BF89_46 ENOG4105ETE Transcriptional regulator (LacI family BF89_4600 ENOG41073R8 VanW family BF89_4601 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_4603 ENOG4105KT7 mgtC SapB transporter BF89_4605 ENOG4105E39 Enoyl-CoA hydratase BF89_4606 ENOG4105K64 Glycosyl transferase, family 2 BF89_4608 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF89_461 ENOG4108VXD carboxy-peptidase BF89_4612 ENOG4105CQB FAD linked oxidase domain protein BF89_4613 ENOG4105C09 Bile acid BF89_4615 ENOG4105RHY Pfam:UPF0157 BF89_4622 ENOG4105CIS alcohol dehydrogenase BF89_4623 ENOG41082BM Transcriptional regulator, arsr family BF89_4627 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF89_463 ENOG4108ZRV stage ii sporulation protein p BF89_4633 ENOG4108A04 Beta-lactamase BF89_4634 ENOG4105DPN Oligoendopeptidase f BF89_4635 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF89_4637 ENOG4105E5K Alpha-amylase BF89_4639 ENOG4105C98 muts2 protein BF89_4643 ENOG4107V2S Transcriptional regulator BF89_4645 ENOG4107CUJ Protein of unknown function (DUF2690) BF89_4649 ENOG4107ZY0 Phenazine biosynthesis-like protein BF89_4650 ENOG4105NX3 Membrane BF89_4651 ENOG4105DQ5 transport system permease protein BF89_4652 ENOG4105EHG Permease protein BF89_4654 ENOG4108MES Periplasmic binding protein BF89_4658 ENOG4107R3E Citrate transporter BF89_4660 ENOG4108TN2 lmbE family BF89_4667 ENOG4105CIS alcohol dehydrogenase BF89_467 ENOG4108Z7R Chaperone CsaA BF89_4674 ENOG4105H3G oxidoreductase BF89_4676 ENOG4105ED2 Beta-lactamase BF89_4681 ENOG4107YXZ hydrolase, family 25 BF89_4686 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF89_4691 ENOG4105KAF membrAne BF89_47 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF89_4701 ENOG4108ZJ4 polysaccharide deacetylase BF89_4705 ENOG4105KVH Transcriptional regulator BF89_4706 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF89_471 ENOG4105C37 (CBS) domain BF89_4710 ENOG4105CHR reductase BF89_4712 ENOG4105JAB phenazine biosynthesis protein, phzf family BF89_4719 ENOG4105KVH Transcriptional regulator BF89_472 ENOG4105SXS Protein of unknown function (DUF456) BF89_4720 ENOG4105KVH Transcriptional regulator BF89_4721 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF89_4722 ENOG4105D9R oxidoreductase BF89_4723 ENOG4108TZY GntR Family Transcriptional Regulator BF89_4724 ENOG4105KVH Transcriptional regulator BF89_4730 ENOG4105C44 Serine transporter BF89_4731 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF89_4734 ENOG4105F27 Major Facilitator BF89_4735 ENOG4105CV8 reductase BF89_4739 ENOG4105D4Y metalloprotease BF89_4740 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF89_4743 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF89_4744 ENOG4105CIS alcohol dehydrogenase BF89_4745 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF89_4746 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF89_4749 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF89_4750 ENOG4105C6Z Gluconate BF89_4751 ENOG4105CMG Carbohydrate kinase BF89_4752 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF89_4753 ENOG4105XDF Protein of unknown function (DUF1272) BF89_4754 ENOG4105DDN Pentapeptide repeat-containing protein BF89_4757 ENOG4105C37 (CBS) domain BF89_476 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF89_4764 ENOG4105EV4 Multidrug resistance protein mdtH BF89_4766 ENOG4105DMQ Methyltransferase BF89_477 ENOG4108S4H thioesterase Superfamily protein BF89_4771 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF89_4772 ENOG4105C31 Tryptophanyl-tRNA synthetase BF89_4774 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF89_4776 ENOG4108UW5 maltose o-acetyltransferase BF89_4777 ENOG4106UW1 Major Facilitator superfamily BF89_4778 ENOG4105DKQ ROK family BF89_4779 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_479 ENOG4108PJD permease BF89_4791 ENOG4105CJ1 ABC, transporter BF89_4793 ENOG4108PSK reductase BF89_4797 ENOG4108RCM Nitroreductase BF89_4798 ENOG4105KVH Transcriptional regulator BF89_4801 ENOG4105CUT histidyl-tRNA synthetase BF89_4802 ENOG4108Z66 YbaK ebsC protein BF89_4804 ENOG41067QW Transcriptional regulator BF89_4807 ENOG4108K8S endonuclease I BF89_4812 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF89_4813 ENOG4108JJB ABC transporter BF89_482 ENOG4107T5V SNARE associated Golgi BF89_4820 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF89_4822 ENOG4105CRW Short chain fatty acid transporter BF89_4824 ENOG4105KBX Transcriptional regulator, TetR family BF89_4825 ENOG4105KPY Small multidrug resistance protein BF89_4826 ENOG4105RXJ BF89_4828 ENOG41069JR BF89_4829 ENOG4105DA5 (ABC) transporter BF89_4833 ENOG4105CZM Major Facilitator BF89_4834 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF89_4836 ENOG4108ISG Major Facilitator BF89_4844 ENOG4105HIR S-layer domain protein BF89_4847 ENOG410874W AraC family transcriptional regulator BF89_4848 ENOG41082W1 Cupin 2, conserved barrel domain protein BF89_4851 ENOG4108AEY RNA polymerase sigma factor BF89_4855 ENOG4108JQ1 Dehydrogenase BF89_4858 ENOG4105DVH amino acid BF89_486 ENOG4105CVJ phosphoglycerate mutase BF89_4864 ENOG4108JPW Aminotransferase BF89_4866 ENOG4105EJQ L-serine dehydratase BF89_4867 ENOG4105C44 Serine transporter BF89_4870 ENOG4108JGH Tetr family transcriptional regulator BF89_4871 ENOG4105EQ0 Major Facilitator superfamily BF89_4872 ENOG4105MZU cell filamentation protein BF89_4875 ENOG4107QJQ Mate efflux family protein BF89_4882 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF89_4890 ENOG4105TRI Hydrolase BF89_4896 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF89_4898 ENOG4106P55 Transcriptional regulator BF89_49 ENOG4107RF6 penicillin-binding protein BF89_4900 ENOG4107QR9 Iron-sulfur cluster binding protein BF89_4901 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF89_4902 ENOG4105DJB Major Facilitator Superfamily BF89_4903 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF89_4905 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF89_4906 ENOG4108U05 Transcriptional regulator BF89_4909 ENOG4105BZU Histidine kinase BF89_491 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF89_4912 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF89_4913 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF89_4916 ENOG4105JQZ Methyltransferase BF89_4917 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF89_4919 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF89_4920 ENOG4108NNI Beta-lactamase domain-containing protein BF89_4923 ENOG4105VZ8 Transcriptional regulator BF89_4929 ENOG4105K6H D-cysteine desulfhydrase BF89_493 ENOG4105K4T epimerase BF89_4934 ENOG41062D9 Histidine kinase BF89_4935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_4938 ENOG4105IIP Membrane BF89_4940 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF89_4941 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF89_495 ENOG4105DSE periplasmic solute binding protein BF89_4954 ENOG4108YXU transcriptional regulator AsnC family BF89_4955 ENOG4105CHR reductase BF89_4957 ENOG4105F7F Chaperone BF89_4961 ENOG41085FC arsR family transcriptional regulator BF89_4962 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF89_4963 ENOG4105D6J arsenicaL-resistance protein BF89_4969 ENOG4105DIK (ABC) transporter BF89_4970 ENOG4105CC5 ABC transporter BF89_4971 ENOG4105DSE periplasmic solute binding protein BF89_4972 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF89_4973 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF89_4975 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF89_4976 ENOG4108TWJ NADH dehydrogenase subunit 5 BF89_4979 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF89_4980 ENOG4108606 TspO/MBR family BF89_4987 ENOG41090MY MarR family Transcriptional regulator BF89_4993 ENOG4105CHJ isochorismatase hydrolase BF89_4995 ENOG4105CH6 catalase BF89_4996 ENOG4105CGH 5'-nucleotidase BF89_5 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF89_50 ENOG4107RF6 penicillin-binding protein BF89_5004 ENOG4105CSV Glutaminase BF89_5008 ENOG4108Q8B Spore germination protein BF89_5009 ENOG4108NHD germination protein BF89_5011 ENOG4105C6K Malic enzyme BF89_5013 ENOG4105II7 pyrroline-5-carboxylate reductase BF89_5015 ENOG4105CUB amino acid BF89_5016 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF89_5018 ENOG4108IMY Transcriptional regulator BF89_5019 ENOG4105HDK L-asparaginase BF89_5020 ENOG4108IJ0 Aspartate ammonia-lyase BF89_5023 ENOG4105E2A Dehydrogenase BF89_5038 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF89_5044 ENOG4105DWD nucleoside recognition domain protein BF89_5048 ENOG4105FDT acyl-CoA dehydrogenase BF89_5050 ENOG4108ZHR arsR family transcriptional regulator BF89_5051 ENOG4108ZRV stage ii sporulation protein p BF89_5052 ENOG4106N3A copper homeostasis protein cutc BF89_5054 ENOG4107258 Transcriptional regulator BF89_5055 ENOG4105P4J Allophanate hydrolase, subunit 1 BF89_5063 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF89_5065 ENOG4107RF6 penicillin-binding protein BF89_507 ENOG4105CKI cobalamin synthesis protein BF89_5073 ENOG4105F1N DNA alkylation repair BF89_5075 ENOG4108IQI permease BF89_5076 ENOG4105KNA -acetyltransferase BF89_5077 ENOG410635A Membrane BF89_508 ENOG4107QM2 Aldo Keto reductase BF89_5093 ENOG4108XET gCN5-related N-acetyltransferase BF89_5099 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF89_5101 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF89_5108 ENOG4105FS7 Transcriptional regulator BF89_5109 ENOG4108TVJ Nitroreductase BF89_5111 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF89_512 ENOG4105DEN Luciferase family BF89_5120 ENOG4105C8Y Acetylornithine aminotransferase BF89_5122 ENOG4105CKK Glycosyl transferase, family 2 BF89_5127 ENOG4105CKK Glycosyl transferase, family 2 BF89_5133 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF89_5138 ENOG41068WN BF89_5140 ENOG4108WCX response regulator BF89_5142 ENOG41090T1 Membrane BF89_5145 ENOG4105VMP Transcriptional regulator BF89_5147 ENOG4105G6Z alkaline phosphatase BF89_5148 ENOG4105ECK Fatty Acid Desaturase BF89_5149 ENOG4105E0Y RtcB Protein BF89_515 ENOG4108WPJ Ferritin-like domain BF89_5151 ENOG4107258 Transcriptional regulator BF89_5153 ENOG4105II7 pyrroline-5-carboxylate reductase BF89_5154 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF89_516 ENOG4108K88 Membrane BF89_5160 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF89_5164 ENOG41061GT Aldolase BF89_5166 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF89_5167 ENOG4105DKT Transcriptional regulator BF89_5169 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF89_5171 ENOG4105D4B ABC, transporter BF89_5177 ENOG4105EMN RNA polymerase sigma factor BF89_5179 ENOG41069ER domain protein BF89_5187 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF89_5188 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF89_5189 ENOG4105CIH Imidazole acetol-phosphate transaminase BF89_519 ENOG4105C8Q Methyl-accepting chemotaxis BF89_5193 ENOG41082JN Transcriptional regulator BF89_5194 ENOG4105EYF MMPL domain protein BF89_5195 ENOG4105EYF MMPL domain protein BF89_5197 ENOG4105C5H ABC transporter BF89_5198 ENOG4105E0M Sulfatase BF89_5199 ENOG4108ZCF integral membrane protein BF89_5201 ENOG4107VMI polysaccharide deacetylase BF89_5213 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF89_5217 ENOG4105E09 nadh pyrophosphatase BF89_5223 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF89_5224 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF89_5225 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF89_5227 ENOG4105C02 permease BF89_5236 ENOG4105DVE abc transporter atp-binding protein BF89_524 ENOG4107XZQ multidrug resistance protein BF89_5242 ENOG4105CHM Aminotransferase BF89_5249 ENOG41089UC methyltransferase, type 11 BF89_525 ENOG4107SET aldo keto reductase BF89_5252 ENOG4107BMA Transglycosylase associated protein BF89_5256 ENOG4106K7D Major facilitator family transporter BF89_5257 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF89_526 ENOG4105YVS arsR family transcriptional regulator BF89_5265 ENOG4105EPR degv family BF89_5268 ENOG4105DPN Oligoendopeptidase f BF89_5275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF89_5276 ENOG4105BZU Histidine kinase BF89_5277 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF89_528 ENOG4105KRN Transcriptional regulator, abrb family BF89_5285 ENOG4105DTQ mandelate racemase muconate lactonizing BF89_5288 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF89_5289 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF89_5292 ENOG4107T5V SNARE associated Golgi BF89_5299 ENOG41080HI glycine oxidase BF89_5300 ENOG4105CTU Proline racemase BF89_5301 ENOG4105CTU Proline racemase BF89_5302 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF89_5303 ENOG4105C26 Dehydrogenase BF89_5304 ENOG4105BZG amino acid carrier protein BF89_5307 ENOG4108M1A Chitin-binding protein BF89_5316 ENOG4105C9U ATP-dependent DNA helicase RecQ BF89_5320 ENOG4105EEM helicase BF89_5324 ENOG4108Z7F N-acetyltransferase BF89_5330 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF89_5340 ENOG4108M1A Chitin-binding protein BF89_5341 ENOG41082BV acetyltransferase BF89_5342 ENOG4105E66 phosphoriboisomerase A BF89_5347 ENOG4108IJ7 Glycine betaine BF89_5348 ENOG4107SQ8 Glycine betaine BF89_5354 ENOG4105RHY Pfam:UPF0157 BF89_5355 ENOG4105E1F short-chain dehydrogenase reductase BF89_5357 ENOG4107RUY (E1 component), alpha subunit BF89_5359 ENOG4107QKR Dehydrogenase BF89_5364 ENOG41062ES Transcriptional regulator BF89_5368 ENOG4105E98 transcriptional regulator DeoR family BF89_5372 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF89_5378 ENOG4107Z3H Transcriptional regulator, TetR family BF89_5379 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF89_538 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF89_5380 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF89_5381 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF89_5385 ENOG4105MSI germination protein ypeb BF89_5389 ENOG4108V3A UPF0421 protein BF89_5396 ENOG4105FDR Membrane BF89_5398 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF89_540 ENOG4105YWU small acid-soluble spore protein BF89_5403 ENOG4108IUM Glycogen debranching enzyme BF89_5407 ENOG4105DY8 decarboxylase BF89_541 ENOG4108WBH protein TIM barrel BF89_5411 ENOG4105PAD Hydrolase BF89_5416 ENOG4107VFR oxidoreductase BF89_5424 ENOG4105PKS Excinuclease abc c subunit domain protein BF89_5431 ENOG4105KWG Pfam:DUF1696 BF89_5432 ENOG4108NRW Phospholipase, patatin family BF89_5438 ENOG4108XI2 Domain of unknown function (DUF1963) BF89_544 ENOG4105CEY Amp-dependent synthetase and ligase BF89_5445 ENOG4108Z4K mutator MutT protein BF89_5446 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF89_5447 ENOG4105E09 nadh pyrophosphatase BF89_5449 ENOG4105FCD Major Facilitator BF89_545 ENOG4105DUU IucA IucC family protein BF89_5456 ENOG4107Y9U Membrane BF89_5461 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF89_5465 ENOG4107Y80 Major Facilitator superfamily BF89_547 ENOG4105VRR gCN5-related N-acetyltransferase BF89_5470 ENOG4108V4B ThiJ pfpI BF89_5478 ENOG4105FQP Beta-lactamase BF89_548 ENOG4105KT7 mgtC SapB transporter BF89_5480 ENOG4105CJN penicillin-binding protein BF89_5481 ENOG4105CB2 alcohol dehydrogenase BF89_5485 ENOG4108HGU Histidine kinase BF89_5488 ENOG4108JJB ABC transporter BF89_5492 ENOG4107RF6 penicillin-binding protein BF89_5493 ENOG4105BZU Histidine kinase BF89_5495 ENOG410667J hydrolase BF89_5498 ENOG4106A3M Cytochrome p-450 BF89_550 ENOG4107VMI polysaccharide deacetylase BF89_551 ENOG4105BZU Histidine kinase BF89_5518 ENOG4105ETU transcriptional activator (TenA BF89_552 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF89_5539 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF89_554 ENOG4108KGH TRANSCRIPTIONal BF89_5540 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF89_5543 ENOG4105CPQ Dehydrogenase BF89_5549 ENOG4105CUV Homoserine Kinase BF89_5552 ENOG4107Y80 Major Facilitator superfamily BF89_5554 ENOG4105FQP Beta-lactamase BF89_5557 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF89_5557 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF89_5567 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF89_5569 ENOG4105T9C HD domain BF89_5572 ENOG4105DZ1 carboxypeptidase BF89_5575 ENOG4105DBI uridine monophosphokinase BF89_5576 ENOG4105WCN acetyltransferase BF89_5578 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF89_559 ENOG4105D6E homoserine dehydrogenase BF89_5590 ENOG4105EKQ RNA-directed DNA polymerase BF89_56 ENOG4105CIN aminoacyl-histidine dipeptidase BF89_5612 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF89_5619 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF89_5621 ENOG4108MEK Metal-binding protein YodA BF89_5623 ENOG4105DQ6 Transposase BF89_5625 ENOG4105DQ6 Transposase BF89_5628 ENOG4105DQ6 Transposase BF89_563 ENOG4108ZJ4 polysaccharide deacetylase BF89_5630 ENOG4108IBT Inherit from COG: transposase BF89_5637 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF89_5639 ENOG4105KRN Transcriptional regulator, abrb family BF89_564 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF89_5662 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF89_5668 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF89_567 ENOG4105BZU Histidine kinase BF89_5677 ENOG4105DQ6 Transposase BF89_5681 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF89_5682 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF89_5685 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF89_5686 ENOG4106AKK s-layer domain-containing protein BF89_569 ENOG4105EFI regulatoR BF89_5692 ENOG4105DHF Membrane BF89_570 ENOG4105BZ1 (ABC) transporter BF89_571 ENOG4105BZ1 (ABC) transporter BF89_5741 ENOG4105CNU cell division protein FtsK BF89_5755 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF89_5767 ENOG4105EKQ RNA-directed DNA polymerase BF89_5778 ENOG4105K4H Nlp p60 protein BF89_579 ENOG4108JJ8 (ABC) transporter BF89_580 ENOG4108JJ9 ABC, transporter BF89_581 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF89_5813 ENOG4107QJE Chromosome Partitioning Protein BF89_5818 ENOG4105DQ6 Transposase BF89_582 ENOG4105C4M (Ubiquinol oxidase) subunit I BF89_5824 ENOG4105EWC Purine nucleoside phosphorylase BF89_584 ENOG4105YGB Transcriptional regulator BF89_5842 ENOG4105C3F Signal peptidase i BF89_5850 ENOG4105N14 lysine exporter protein LysE YggA BF89_5855 ENOG4108J59 Extracellular solute-binding protein, family 5 BF89_5859 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF89_5870 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF89_5871 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF89_588 ENOG4105SKE transcriptional Regulator LysR family BF89_590 ENOG4105C32 Amino acid ABC transporter (Permease) BF89_591 ENOG4108IV0 ABC, transporter BF89_592 ENOG4105C0Z ABC transporter BF89_594 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF89_595 ENOG4108Z7G MaoC domain protein dehydratase BF89_599 ENOG4105CKI cobalamin synthesis protein BF89_6 ENOG4105C1G acyl-Coa dehydrogenase BF89_601 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF89_602 ENOG4106F5Q Membrane BF89_603 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF89_605 ENOG4108TVJ Nitroreductase BF89_606 ENOG4107ZXU DSBA oxidoreductase BF89_607 ENOG4108Z40 Transcriptional regulator BF89_608 ENOG4105GZI Transcriptional regulator BF89_609 ENOG4107RT3 EamA-like transporter family BF89_611 ENOG4105KTB nuclear export factor GLE1 BF89_612 ENOG4108T5E Copper resistance protein BF89_622 ENOG4107STQ Multicopper oxidase BF89_623 ENOG4107RAQ aminopeptidase BF89_629 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF89_63 ENOG41090HR transcriptional regulator BF89_630 ENOG4105D9N nucleoside BF89_632 ENOG4107RHR regulatoR BF89_637 ENOG4105C0X amino acid BF89_638 ENOG4105C0X amino acid BF89_64 ENOG4107RA9 decarboxylase BF89_640 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF89_642 ENOG4105C72 UPF0176 protein BF89_643 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF89_648 ENOG41068WN BF89_65 ENOG4108I0C methyltransferase BF89_653 ENOG4108J59 Extracellular solute-binding protein, family 5 BF89_654 ENOG4105F6J Alpha beta hydrolase fold BF89_658 ENOG4105CYC Transferase BF89_659 ENOG4105DY9 regulatoR BF89_661 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF89_667 ENOG4105PNM synthesis protein BF89_669 ENOG4105C7B Threonine dehydratase BF89_67 ENOG41088CC tellurite resistance protein tehB BF89_671 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF89_672 ENOG4108ZP8 Acetolactate synthase small subunit BF89_673 ENOG4105C7K acetolactate synthase BF89_674 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF89_675 ENOG4105CHR reductase BF89_676 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF89_680 ENOG4106KE4 Dehydrogenase BF89_683 ENOG4105H67 Protein of unknown function (DUF421) BF89_684 ENOG4105X5K response regulator receiver protein BF89_686 ENOG4105C8J )-transporter BF89_690 ENOG4105C6T cysteine synthase BF89_691 ENOG4105C6T cysteine synthase BF89_692 ENOG4105EU0 Major facilitator Superfamily BF89_694 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF89_697 ENOG4105DXI Major Facilitator superfamily BF89_698 ENOG4105CSR polyphosphate kinase 2 BF89_707 ENOG4105FVX BF89_720 ENOG4105C6K Malic enzyme BF89_721 ENOG4108IJ0 Aspartate ammonia-lyase BF89_723 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF89_727 ENOG4105CJ1 ABC, transporter BF89_73 ENOG4108RZE Tetr family transcriptional regulator BF89_734 ENOG4106BRA Membrane BF89_741 ENOG4107QIV Cytochrome c biogenesis protein BF89_745 ENOG4105EC3 peptidase S51, dipeptidase E BF89_746 ENOG4107QJQ Mate efflux family protein BF89_747 ENOG4107QJQ Mate efflux family protein BF89_75 ENOG4105C1J atp-dependent rna helicase BF89_751 ENOG4105C9Q fumarate hydratase class II BF89_752 ENOG4105DFD Na H antiporter BF89_755 ENOG4108PJD permease BF89_756 ENOG4105CKI cobalamin synthesis protein BF89_757 ENOG4108UZ3 Transporter BF89_758 ENOG4105DRR Transcriptional regulator, GntR family BF89_760 ENOG4105PGM cation diffusion facilitator family transporter BF89_764 ENOG4105CAQ asparagine synthetase BF89_771 ENOG4105CVJ phosphoglycerate mutase BF89_778 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF89_779 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF89_78 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF89_780 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF89_781 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF89_782 ENOG4108KB2 LysR family Transcriptional regulator BF89_783 ENOG4105DUM transcriptional regulator, lysR family BF89_788 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF89_792 ENOG4108RZE Tetr family transcriptional regulator BF89_797 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF89_798 ENOG4105KTQ flagellar basal-body rod protein BF89_799 ENOG4105FZW flagellar biosynthesis regulator FlhF BF89_800 ENOG4105D7B Flagellar biosynthesis protein flha BF89_801 ENOG4105D00 flagellar biosynthetic protein flhB BF89_803 ENOG4105VS8 Flagellar biosynthetic protein fliq BF89_804 ENOG4105CN7 Flagellar biosynthetic protein FliP BF89_806 ENOG4105DD5 Flagellar motor switch protein BF89_808 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF89_809 ENOG4105E4C Lytic transglycosylase catalytic BF89_810 ENOG4105I03 Flagellin BF89_815 ENOG4107TVC Glycosyl transferase, family 2 BF89_82 ENOG4107STF Involved in phosphonate degradation (By similarity) BF89_821 ENOG4105K64 Glycosyl transferase, family 2 BF89_823 ENOG4107R88 Chemotaxis protein (CheV) BF89_827 ENOG4105BZE flagellar hook protein, FlgE BF89_834 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF89_836 ENOG4107U2N Flagellar M-ring protein BF89_837 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF89_838 ENOG4108ZC9 flagellar basal-body rod protein flgc BF89_839 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF89_84 ENOG4105RD7 BadF BadG BcrA BcrD BF89_844 ENOG4105DTJ flagellar hook-associated protein BF89_845 ENOG4105E1Q flagellar hook-associated protein BF89_850 ENOG4105BZU Histidine kinase BF89_853 ENOG4105DD5 Flagellar motor switch protein BF89_854 ENOG4105CBS Chea signal transduction histidine kinase BF89_855 ENOG4105CBS Chea signal transduction histidine kinase BF89_856 ENOG4107YTP response regulator receiver protein BF89_857 ENOG4105ER2 Ompa motb domain protein BF89_858 ENOG4107R0U MotA TolQ exbB proton channel BF89_860 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF89_871 ENOG41080C8 DUF218 domain BF89_872 ENOG4105H67 Protein of unknown function (DUF421) BF89_874 ENOG4108Z5V transcriptional regulator, merr family BF89_875 ENOG4105CN5 Metallo-Beta-Lactamase BF89_876 ENOG4107RWR Sodium hydrogen exchanger BF89_878 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF89_89 ENOG4105F32 YngK protein BF89_891 ENOG41081VK Ribonuclease BF89_895 ENOG4108SZE gCN5-related N-acetyltransferase BF89_898 ENOG4105CPK Glycosyl transferase (Group 1 BF89_9 ENOG4107Z3H Transcriptional regulator, TetR family BF89_912 ENOG4106032 Glutathionylspermidine synthase BF89_915 ENOG4105KHC sulfurtransferase BF89_917 ENOG4108W0I acetyltransferase BF89_919 ENOG410890F Dynamin family BF89_921 ENOG4105DHF Membrane BF89_922 ENOG4105C2W permease BF89_924 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF89_927 ENOG4105CTD carboxy-peptidase BF89_928 ENOG4105DVT helicase BF89_930 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF89_94 ENOG4108KPJ rna polymerase sigma factor BF89_941 ENOG4105BZ4 penicillin-binding protein BF89_943 ENOG4105CSM endonuclease III BF89_947 ENOG4105YAC BF89_948 ENOG4105DVT helicase BF89_949 ENOG4105DVT helicase BF89_956 ENOG4105CPK Glycosyl transferase (Group 1 BF89_957 ENOG4105FJR Lmbe family BF89_960 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF89_961 ENOG4108JYZ YitT family BF89_967 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF89_968 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF89_969 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF89_972 ENOG41068YB TPR repeat-containing protein BF89_973 ENOG4105CIH Imidazole acetol-phosphate transaminase BF89_977 ENOG4105EAH synthase BF89_979 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF89_982 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF89_988 ENOG41065D1 BF89_989 ENOG4105S2F BF89_996 ENOG4107RB3 L-asparaginase BF89_997 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase