locus-tag class description BF24_100 ENOG4105DZ1 carboxypeptidase BF24_1005 ENOG4105CIS alcohol dehydrogenase BF24_1012 ENOG4108TN2 lmbE family BF24_1014 ENOG4107R3E Citrate transporter BF24_1018 ENOG4108MES Periplasmic binding protein BF24_1020 ENOG4105EHG Permease protein BF24_1021 ENOG4105DQ5 transport system permease protein BF24_1022 ENOG4105NX3 Membrane BF24_1023 ENOG4107ZY0 Phenazine biosynthesis-like protein BF24_1027 ENOG4107CUJ Protein of unknown function (DUF2690) BF24_1029 ENOG4107V2S Transcriptional regulator BF24_103 ENOG4105T9C HD domain BF24_1033 ENOG4105C98 muts2 protein BF24_1035 ENOG4105E5K Alpha-amylase BF24_1036 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF24_1046 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF24_105 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF24_1050 ENOG41082BM Transcriptional regulator, arsr family BF24_1051 ENOG4105CIS alcohol dehydrogenase BF24_1057 ENOG4105RHY Pfam:UPF0157 BF24_1059 ENOG4105C09 Bile acid BF24_1065 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF24_1067 ENOG4105K64 Glycosyl transferase, family 2 BF24_1068 ENOG4105E39 Enoyl-CoA hydratase BF24_1070 ENOG4105KT7 mgtC SapB transporter BF24_1072 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_1073 ENOG41073R8 VanW family BF24_1075 ENOG4108R1P BF24_1079 ENOG4105VEQ Cold shock protein BF24_1083 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF24_1087 ENOG410904N short-chain dehydrogenase reductase BF24_1089 ENOG4106IQC argininosuccinate lyase BF24_1092 ENOG4108IA2 Sodium pantothenate symporter BF24_1093 ENOG4105RG0 Membrane BF24_1094 ENOG4105C26 Dehydrogenase BF24_1095 ENOG4105CHR reductase BF24_1097 ENOG4105EWU Squalene--hopene cyclase BF24_1099 ENOG4105FR1 rard protein BF24_1100 ENOG410696E Membrane BF24_1103 ENOG4105D1F ATP-binding protein BF24_1105 ENOG4108ZAF Molybdopterin BF24_1106 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF24_1107 ENOG4105D06 uba thif-type nad fad binding protein BF24_1108 ENOG4105TMB Formate nitrite transporter BF24_1110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF24_1111 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF24_1113 ENOG4108JB9 formate dehydrogenase BF24_1115 ENOG4105E1K spore germination protein BF24_1127 ENOG4107QJT sodium dicarboxylate symporter BF24_1128 ENOG4108KGH TRANSCRIPTIONal BF24_1130 ENOG4105EMN RNA polymerase sigma factor BF24_1134 ENOG4105CIG ABC transporter BF24_1136 ENOG4105D9R oxidoreductase BF24_1138 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF24_1139 ENOG4105K4P CoA-binding domain protein BF24_114 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF24_114 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF24_1140 ENOG4105C0H protease BF24_1141 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_1143 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF24_1144 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF24_1145 ENOG4105W8X HesB YadR YfhF-family protein BF24_1151 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF24_1152 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF24_1154 ENOG4108JJA ABC, transporter BF24_1155 ENOG4108I0Z Aconitate hydratase BF24_1160 ENOG4105E5W Transporter BF24_1162 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF24_1166 ENOG4107F3J Amp-dependent synthetase and ligase BF24_1167 ENOG4107ZYJ bioY protein BF24_1168 ENOG4105CEY Amp-dependent synthetase and ligase BF24_117 ENOG4105FQP Beta-lactamase BF24_1177 ENOG4107AYK membrAne BF24_1179 ENOG4105BZU Histidine kinase BF24_1180 ENOG4105FBA Phospholipase Carboxylesterase BF24_1181 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF24_1182 ENOG4105CK7 Sodium proline symporter BF24_1183 ENOG4105CBC glutamate synthase BF24_1184 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF24_1185 ENOG4108VJ1 Transcriptional regulator (CarD family BF24_1186 ENOG4108903 Formimidoylglutamase BF24_119 ENOG4107Y80 Major Facilitator superfamily BF24_1191 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF24_12 ENOG4105RD7 BadF BadG BcrA BcrD BF24_1202 ENOG4107QIV Cytochrome c biogenesis protein BF24_1204 ENOG4107RSM transcriptional regulator BF24_1205 ENOG4105VAW lrga family BF24_1206 ENOG41067MG lrgb family BF24_1211 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF24_1214 ENOG4105BZ1 (ABC) transporter BF24_1215 ENOG4105BZ1 (ABC) transporter BF24_1219 ENOG4105D7V transposase BF24_1222 ENOG4105D5T phosphonate abc transporter BF24_1225 ENOG4105CGH 5'-nucleotidase BF24_1227 ENOG4108SVB resolvase BF24_123 ENOG4105CUV Homoserine Kinase BF24_1231 ENOG4105K7K Transcriptional regulator BF24_1239 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BF24_1240 ENOG4105XSJ toxin secretion phage lysis holin BF24_1280 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF24_129 ENOG4105CPQ Dehydrogenase BF24_1301 ENOG4105C5F glutamine synthetase BF24_1302 ENOG4105KV4 Transcriptional regulator BF24_1303 ENOG4105CXI aluminum resistance protein BF24_1304 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF24_1305 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF24_1306 ENOG4105EN6 Membrane BF24_1307 ENOG4106F1P AAA ATPase, central domain protein BF24_1314 ENOG41069ER domain protein BF24_1315 ENOG4105DM4 PTS System BF24_1316 ENOG4105DE4 1-phosphofructokinase BF24_1317 ENOG4105E98 transcriptional regulator DeoR family BF24_1318 ENOG4107QW4 alcohol dehydrogenase BF24_1319 ENOG4107QW4 alcohol dehydrogenase BF24_132 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF24_1320 ENOG4108SJC Membrane BF24_1323 ENOG4105C85 amino acid BF24_1327 ENOG4105TMB Formate nitrite transporter BF24_1328 ENOG4105K70 DNA-binding protein BF24_1329 ENOG4105C59 p-type ATPase BF24_133 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF24_1330 ENOG410681U heavy metal transport detoxification protein BF24_1331 ENOG4105VPX protein, conserved in bacteria BF24_1333 ENOG4105NIV Esterase BF24_1334 ENOG4105E0A ABC, transporter BF24_1339 ENOG4105CGK Exodeoxyribonuclease III BF24_1341 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF24_1342 ENOG4105D03 DNA-3-methyladenine glycosylase II BF24_1348 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_1349 ENOG4105BZU Histidine kinase BF24_1352 ENOG41067MG lrgb family BF24_1355 ENOG4107TTQ Alpha beta hydrolase fold BF24_1356 ENOG4107YEI lmbE family BF24_1360 ENOG4105F0V Cell wall hydrolase BF24_1361 ENOG4107R6R udp-galactopyranose mutase BF24_1362 ENOG4105E0M Sulfatase BF24_1363 ENOG410890F Dynamin family BF24_1365 ENOG4107QHE Choloylglycine hydrolase BF24_1370 ENOG4105DA5 (ABC) transporter BF24_1375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF24_1376 ENOG4105DQU oxidoreductase, subunit beta BF24_1377 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF24_1378 ENOG4108IGT Dipeptidase BF24_1379 ENOG4105MCT stage V sporulation protein S BF24_1380 ENOG4105D48 metallophosphoesterase BF24_1385 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF24_1388 ENOG4105XZV Protein of unknown function (DUF3243) BF24_1389 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF24_1393 ENOG4105UIB (ABC) transporter BF24_1394 ENOG4105UIB (ABC) transporter BF24_1395 ENOG4108JQ9 ABC transporter BF24_1396 ENOG4105DIH basic membrane BF24_1397 ENOG4105FDP GntR family transcriptional regulator BF24_1398 ENOG4107QZI cell division protein FtsK BF24_14 ENOG4107STF Involved in phosphonate degradation (By similarity) BF24_1400 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF24_1402 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF24_1404 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF24_1405 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF24_1406 ENOG4105E35 Dipicolinate synthase subunit A BF24_1408 ENOG4105C1V Peptidase, M16 BF24_1412 ENOG4105DTN riboflavin biosynthesis protein ribF BF24_1413 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF24_1415 ENOG4105W7A Protein of unknown function (DUF503) BF24_1417 ENOG4105VHM ribosomal protein BF24_1418 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF24_1419 ENOG4105CHV Transcription elongation factor NusA BF24_1421 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF24_1423 ENOG4105DZP Membrane-associated zinc metalloprotease BF24_1424 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF24_1425 ENOG4105KNE Phosphatidate cytidylyltransferase BF24_1426 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF24_1434 ENOG4108HE4 integrase family BF24_1436 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF24_1438 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF24_1441 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF24_1446 ENOG4105VB6 UPF0109 protein BF24_1450 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF24_1451 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF24_1454 ENOG4105CHR reductase BF24_1455 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF24_1458 ENOG4105CB5 ATP-dependent DNA helicase recG BF24_1459 ENOG4105DP4 dak2 domain fusion protein ylov BF24_1460 ENOG4108ZAA Alkaline-shock protein BF24_1462 ENOG4105FJ0 thiamine BF24_1463 ENOG4105DJV ribulose-phosphate 3-epimerase BF24_1464 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF24_1465 ENOG4105D9P serine threonine protein kinase BF24_1466 ENOG4108ZF3 Phosphatase BF24_1468 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF24_1470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF24_1471 ENOG4105C25 Primosomal protein n' BF24_1472 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF24_1476 ENOG4105DSJ YicC domain protein BF24_1478 ENOG4105F23 Fibronectin-binding protein BF24_1479 ENOG4105DC7 peptidase M24 BF24_1490 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF24_1495 ENOG4105C34 Pseudouridine synthase BF24_1498 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF24_1500 ENOG4105DBK s4 domain protein BF24_1501 ENOG41067XK integral membrane protein BF24_1503 ENOG4105DFA alanine racemase domain protein BF24_1504 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF24_1505 ENOG4105WR5 sporulation protein, YlmC YmxH family BF24_1507 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_1509 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF24_1510 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF24_1511 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF24_1512 ENOG4105D4A Cell wall formation (By similarity) BF24_1513 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF24_1514 ENOG4105CNI cell division protein FtsW BF24_1517 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF24_1518 ENOG4105CJN penicillin-binding protein BF24_1519 ENOG4105CJN penicillin-binding protein BF24_1520 ENOG41068DC Essential cell division protein (By similarity) BF24_1527 ENOG4105KNH Nucleic acid-binding protein BF24_1537 ENOG4105XSJ toxin secretion phage lysis holin BF24_154 ENOG4105ETU transcriptional activator (TenA BF24_1555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF24_1557 ENOG4105CAR Terminase, large subunit BF24_1574 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF24_1577 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_1588 ENOG4108IMY Transcriptional regulator BF24_1596 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF24_1598 ENOG41063PX domain protein BF24_1599 ENOG4105D78 K07001 NTE family protein BF24_1601 ENOG4105H20 Sporulation integral membrane protein YlbJ BF24_1602 ENOG4106H78 methyltransferase BF24_1607 ENOG4107TB6 phosphoglycerate mutase BF24_1610 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF24_1620 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF24_1621 ENOG4105CNI cell division protein FtsW BF24_1624 ENOG4108IAB Phoh family BF24_1628 ENOG4105QA2 BF24_1629 ENOG4105CI3 gtp-binding protein typa BF24_1631 ENOG4105ECY inositol monophosphatase BF24_1635 ENOG4105CXN decarboxylase BF24_1644 ENOG4105C7S Dehydrogenase BF24_1645 ENOG4105CPP Dehydrogenase, E1 component BF24_1648 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF24_1649 ENOG4108X4Q Hydrolase BF24_1651 ENOG4105CN5 Metallo-Beta-Lactamase BF24_1652 ENOG4107ZYR domain protein BF24_1659 ENOG4108XRC Protein of unknown function (DUF458) BF24_1661 ENOG4107IN1 Protein of unknown function (DUF1797) BF24_1664 ENOG4105EPM Diguanylate phosphodiesterase BF24_1665 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF24_1668 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF24_1670 ENOG4105UIN BF24_1681 ENOG4108HGU Histidine kinase BF24_1683 ENOG4105CHM Aminotransferase BF24_1684 ENOG4105FKQ transcriptional regulator BF24_1685 ENOG4105EG2 ABC transporter, permease BF24_1687 ENOG4107FKK extracellular solute-binding protein family 1 BF24_1689 ENOG4105CG3 alpha amylase, catalytic region BF24_17 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF24_1706 ENOG4105K7K Transcriptional regulator BF24_1707 ENOG4105DTD Dehydrogenase BF24_1709 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF24_1711 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF24_1716 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BF24_1719 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF24_1720 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF24_1721 ENOG4106TD9 Diguanylate cyclase BF24_1725 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF24_1728 ENOG4105CID antiterminator BF24_1730 ENOG4105FDP GntR family transcriptional regulator BF24_1732 ENOG4105CE4 GlcNAc 6-P deacetylase BF24_1739 ENOG4107ZE5 PPIases accelerate the folding of proteins BF24_1742 ENOG4105J7I hydrolase BF24_1744 ENOG4105G6R Stage v sporulation protein ae BF24_1746 ENOG4105CZ3 stage V sporulation protein ad BF24_1747 ENOG41090VF Stage v sporulation protein ac BF24_1751 ENOG4105C8J )-transporter BF24_1752 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_1754 ENOG41082AN stage II sporulation protein BF24_1755 ENOG4105DZ1 carboxypeptidase BF24_1756 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF24_1757 ENOG4105DVE abc transporter atp-binding protein BF24_1763 ENOG4105D7N magnesium and cobalt transport protein CorA BF24_1768 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF24_177 ENOG410667J hydrolase BF24_1770 ENOG4105I3K Ferric uptake regulator, Fur family BF24_1771 ENOG4105MZ9 stage II sporulation protein m BF24_1775 ENOG4105CPC Aldo Keto reductase BF24_1777 ENOG4105RHY Pfam:UPF0157 BF24_1781 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF24_1783 ENOG4105ETE Transcriptional regulator (LacI family BF24_1784 ENOG4108YM7 Gcn5-related n-acetyltransferase BF24_1788 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF24_1789 ENOG4108R6K riboflavin synthase, subunit alpha BF24_179 ENOG4105BZU Histidine kinase BF24_1793 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF24_1794 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF24_1795 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF24_1796 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF24_1798 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF24_180 ENOG4107RF6 penicillin-binding protein BF24_1800 ENOG4105DFD Na H antiporter BF24_1801 ENOG4105CGH 5'-nucleotidase BF24_1809 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF24_1812 ENOG4108IXY short-chain dehydrogenase reductase BF24_1813 ENOG41069FQ Metallo-beta-lactamase superfamily BF24_1815 ENOG4105II7 pyrroline-5-carboxylate reductase BF24_1816 ENOG4105EJQ L-serine dehydratase BF24_1820 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF24_1822 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF24_1823 ENOG4105D9U N-acetyltransferase BF24_1825 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF24_1826 ENOG4108QEG Membrane BF24_1827 ENOG4105CDA abc transporter atp-binding protein BF24_1828 ENOG4105E5Q amino acid AbC transporter BF24_1829 ENOG4108HW3 (ABC) transporter BF24_1831 ENOG4105G7B Protein of unknown function (DUF2992) BF24_1832 ENOG4105E09 nadh pyrophosphatase BF24_1834 ENOG4105C7S Dehydrogenase BF24_1835 ENOG4105CPP Dehydrogenase, E1 component BF24_1839 ENOG4107RDP Dehydrogenase BF24_184 ENOG4108JJB ABC transporter BF24_1841 ENOG4108JUB Transcriptional regulator BF24_1843 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF24_1846 ENOG4107QQR Sporulation BF24_1847 ENOG4105S1Z Stage IV sporulation protein B BF24_1848 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF24_1850 ENOG4105DX0 Hemolysin A BF24_1852 ENOG4105CTB Polyprenyl synthetase BF24_1857 ENOG4108ZSR alkaline shock protein BF24_1858 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF24_1863 ENOG410644B Stage III sporulation protein af BF24_1865 ENOG4105KQ4 Stage iii sporulation protein ad BF24_1866 ENOG4108CQH stage III sporulation protein AC BF24_1867 ENOG4105KR5 Stage iii sporulation protein BF24_1868 ENOG4105CD2 stage iii sporulation protein aa BF24_187 ENOG4108HGU Histidine kinase BF24_1873 ENOG4105DC7 peptidase M24 BF24_1876 ENOG4105CBJ Metal-dependent enzyme BF24_1877 ENOG4107YBY Hydrolase BF24_1882 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF24_1883 ENOG4105WZW rhodanese family BF24_1887 ENOG41080TC multidrug resistance protein BF24_1894 ENOG4105CJ1 ABC, transporter BF24_1895 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF24_190 ENOG4105CB2 alcohol dehydrogenase BF24_1901 ENOG4105C0D helicase BF24_191 ENOG4105CJN penicillin-binding protein BF24_1925 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF24_1926 ENOG4105C3R Methionine synthase BF24_1928 ENOG4105C28 cystathionine BF24_1929 ENOG4105C28 cystathionine BF24_193 ENOG4105FQP Beta-lactamase BF24_1933 ENOG4105C5X domain protein BF24_1935 ENOG4105DKQ ROK family BF24_1937 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF24_1940 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF24_1941 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF24_1942 ENOG4105E2Z phosphate ABC transporter (Permease BF24_1943 ENOG4105C8U phosphate abc transporter BF24_1944 ENOG4105PWN phosphate abc transporter BF24_1945 ENOG4107RF6 penicillin-binding protein BF24_1947 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF24_1952 ENOG4105N80 Ferric uptake regulator, Fur family BF24_1954 ENOG4105FDK ABC transporter BF24_1955 ENOG4108JYZ YitT family BF24_1956 ENOG41069ZM Protein of unknown function (DUF2624) BF24_1961 ENOG4105EGD dinuclear metal center protein, YbgI family BF24_1964 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_1965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF24_1970 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF24_1971 ENOG4105KG3 cytidine deaminase BF24_1972 ENOG4107YR5 Diacylglycerol kinase BF24_1974 ENOG4105CTJ Metal Dependent Phosphohydrolase BF24_1975 ENOG4105C9A Phoh family BF24_1977 ENOG41068P3 sporulation protein YqfC BF24_1978 ENOG4105KTH gatB Yqey BF24_1980 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF24_1981 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF24_1985 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF24_1987 ENOG4105CSA Coproporphyrinogen iii oxidase BF24_1988 ENOG4105KVH Transcriptional regulator BF24_199 ENOG4108V4B ThiJ pfpI BF24_1993 ENOG4105TQK DNA polymerase iii, delta' subunit BF24_1995 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF24_1996 ENOG4108UK2 deaminase BF24_1997 ENOG4105KQC Competence protein BF24_2 ENOG4108KPJ rna polymerase sigma factor BF24_20 ENOG4105C1J atp-dependent rna helicase BF24_2000 ENOG4105DXX methyltransferase BF24_2002 ENOG4108WF2 Metal Dependent Phosphohydrolase BF24_2004 ENOG410812S Rna-binding protein BF24_2006 ENOG4105CQW ribosome biogenesis GTPase YqeH BF24_2007 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF24_2010 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_2015 ENOG4108TVJ Nitroreductase BF24_2018 ENOG4105G6Z alkaline phosphatase BF24_2020 ENOG4108MUZ hydrolase BF24_2027 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF24_2028 ENOG4105MIR Phenylalanine 4-monooxygenase BF24_2030 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_2031 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_2039 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF24_204 ENOG4107Y80 Major Facilitator superfamily BF24_2040 ENOG4108V5C ABC transporter BF24_2042 ENOG4108EKI Dehydrogenase BF24_2043 ENOG4105C28 cystathionine BF24_2049 ENOG4107XRG penicillin-binding protein BF24_2052 ENOG4105CFP Peptidase U32 BF24_2053 ENOG4105XYU peptidase (U32 family) BF24_2054 ENOG4108VQJ O-methyltransferase BF24_2055 ENOG4105HHA aminodeoxychorismate lyase BF24_2059 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF24_2061 ENOG4105C02 permease BF24_2064 ENOG41060CR BF24_2065 ENOG4105C7H Helicase, RecD TraA family BF24_2067 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF24_2068 ENOG4105C3J Cysteine desulfurase BF24_2070 ENOG4105D1H recombination factor protein RarA BF24_2071 ENOG4108VCI transcription factor, rsfa family BF24_2072 ENOG4105CUZ uba thif-type nad fad binding protein BF24_2074 ENOG4105CUT histidyl-tRNA synthetase BF24_2077 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF24_2079 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF24_208 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF24_2080 ENOG41076HS cation diffusion facilitator family transporter BF24_2081 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF24_2083 ENOG4105CKP Polysaccharide Biosynthesis Protein BF24_2084 ENOG4108QG2 Membrane BF24_2086 ENOG4105VIE preprotein translocase, subunit YajC BF24_2089 ENOG41061AI Protein of unknown function (DUF2905) BF24_2092 ENOG4108HUF Transporter BF24_2094 ENOG4108IPJ Membrane BF24_2095 ENOG4108IPJ Membrane BF24_2096 ENOG41082BM Transcriptional regulator, arsr family BF24_2102 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF24_2103 ENOG4108IYU L-aspartate oxidase BF24_2106 ENOG4108RPX mosc domain containing protein BF24_2107 ENOG4105CQC Prephenate dehydratase BF24_2111 ENOG4105EWM Histidine kinase BF24_2114 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF24_2117 ENOG4105X36 (ribosomal) protein BF24_2119 ENOG4105C03 ribonuclease BF24_2122 ENOG4107QMS site-determining protein BF24_2125 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF24_2126 ENOG4105DFF Rod shape-determining protein mreb BF24_213 ENOG4107Y9U Membrane BF24_2130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF24_2131 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF24_2133 ENOG41068KH stage VI sporulation protein D BF24_2135 ENOG4105D52 delta-aminolevulinic acid dehydratase BF24_2140 ENOG4105K56 Transcriptional regulator BF24_2144 ENOG4108IUQ atp-dependent protease BF24_2150 ENOG4108QCI YvbH-like oligomerisation region BF24_2154 ENOG4105M59 Phosphodiesterase, mj0936 family BF24_2155 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF24_2157 ENOG4108XJQ germination protein BF24_2159 ENOG4108PCX Major Facilitator BF24_2161 ENOG4105KBX Transcriptional regulator, TetR family BF24_2164 ENOG4105PFC Transcriptional regulator BF24_2167 ENOG4105DZC cytosine deaminase BF24_2168 ENOG4105DZC cytosine deaminase BF24_2169 ENOG4105DEF Extracellular solute-binding protein, family 5 BF24_2170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF24_2173 ENOG4108JQ7 (ABC) transporter BF24_2174 ENOG4108HRK Histidine kinase BF24_2175 ENOG4105DY9 regulatoR BF24_2178 ENOG41067S9 phage shock protein C, PspC BF24_2179 ENOG4108JCI Transcriptional regulator BF24_2181 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF24_2182 ENOG4108Z40 Transcriptional regulator BF24_2183 ENOG4105RHA ABC transporter, permease BF24_2184 ENOG4108IUX (ABC) transporter BF24_2185 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF24_2186 ENOG4105ER2 Ompa motb domain protein BF24_2187 ENOG4105ER2 Ompa motb domain protein BF24_2188 ENOG4105E14 MotA TolQ exbB proton channel BF24_2189 ENOG4108VXD carboxy-peptidase BF24_2191 ENOG4105E33 succinate dehydrogenase BF24_2193 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF24_2196 ENOG4105K63 Thioredoxin BF24_2197 ENOG4105C10 Electron transfer flavoprotein BF24_2198 ENOG4105BZJ Electron transfer flavoprotein BF24_2199 ENOG41060WC Enoyl-CoA hydratase BF24_22 ENOG4108RZE Tetr family transcriptional regulator BF24_2200 ENOG4107Z3H Transcriptional regulator, TetR family BF24_2201 ENOG4105CEY Amp-dependent synthetase and ligase BF24_2203 ENOG4105J76 Periplasmic binding protein BF24_2204 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF24_2213 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_2216 ENOG4105DR4 Methyltransferase BF24_2219 ENOG4105KFN sortase, SrtB family BF24_2220 ENOG4105E0A ABC, transporter BF24_2223 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF24_2225 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF24_2227 ENOG4105FE9 pseudouridine synthase BF24_223 ENOG4105E09 nadh pyrophosphatase BF24_2230 ENOG4105DCG PHP domain protein BF24_2237 ENOG4105C5S asparaginyl-tRNA synthetase BF24_2238 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF24_224 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF24_2240 ENOG4108RWN rrna methyltransferase BF24_2249 ENOG4105CW7 secretion protein, HlyD family BF24_225 ENOG4108Z4K mutator MutT protein BF24_2250 ENOG4108JGH Tetr family transcriptional regulator BF24_2251 ENOG4105CN9 Peptidase m42 family protein BF24_2255 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF24_2256 ENOG4105C22 threonyL-tRNA synthetase BF24_2257 ENOG4108TDW sporulation protein YtxC BF24_2261 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF24_2262 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF24_2263 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF24_2265 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF24_2266 ENOG4105C2M dna polymerase I BF24_2267 ENOG4105BZU Histidine kinase BF24_2268 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_2272 ENOG4108HMX isocitrate dehydrogenase (NADP) BF24_2273 ENOG4105BZN citrate synthase BF24_2275 ENOG4108REF Sporulation integral membrane protein ytvi BF24_2276 ENOG4105FS0 cytoplasmic membrane protein BF24_2281 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF24_2282 ENOG4105C6K Malic enzyme BF24_2283 ENOG4105C0B DNA polymerase III (alpha subunit) BF24_2284 ENOG4105VV2 BF24_2286 ENOG4105SFS phosphoesterase RecJ domain protein BF24_2293 ENOG4105DC7 peptidase M24 BF24_2300 ENOG4105Z7P Acetyltransferase (GNAT) family BF24_2301 ENOG41082W1 Cupin 2, conserved barrel domain protein BF24_2303 ENOG4105VZ8 Transcriptional regulator BF24_2307 ENOG4107YZX Universal stress protein BF24_2316 ENOG4108JYZ YitT family BF24_232 ENOG4108XI2 Domain of unknown function (DUF1963) BF24_2320 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF24_2322 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF24_2323 ENOG4105KBJ sporulation protein ytfj BF24_2326 ENOG4105EFZ amidohydrolase BF24_2328 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF24_2333 ENOG4106KR7 LysR family Transcriptional regulator BF24_2335 ENOG4105U5Y Transcriptional regulator BF24_2336 ENOG4105U5Y Transcriptional regulator BF24_2338 ENOG4105C28 cystathionine BF24_2342 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF24_2344 ENOG4105EMN RNA polymerase sigma factor BF24_2347 ENOG4105F1V Acetoin utilization protein BF24_2348 ENOG4105W87 Cbs domain BF24_2349 ENOG4105DGU Histone deacetylase BF24_2351 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_2352 ENOG4105BZU Histidine kinase BF24_2354 ENOG4105EP9 oxidoreductase BF24_2360 ENOG4105ETE Transcriptional regulator (LacI family BF24_2364 ENOG4105C88 aminopeptidase BF24_2373 ENOG4108VDD TRNA binding domain protein BF24_2379 ENOG4105C8F Beta-lactamase domain protein BF24_238 ENOG4108NRW Phospholipase, patatin family BF24_2382 ENOG4108V15 phosphotransferase enzyme family BF24_2383 ENOG4108IUM Glycogen debranching enzyme BF24_2385 ENOG4107QSE Dipeptidase BF24_2386 ENOG4107QSE Dipeptidase BF24_2387 ENOG4105YW5 deoR family transcriptional regulator BF24_239 ENOG4105KWG Pfam:DUF1696 BF24_2390 ENOG4105CBX hi0933 family BF24_2397 ENOG4108VJ1 Transcriptional regulator (CarD family BF24_2398 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF24_2399 ENOG4105CSC Glucose uptake protein BF24_2402 ENOG4108ZAF Molybdopterin BF24_2403 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF24_2404 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF24_2406 ENOG4105D06 uba thif-type nad fad binding protein BF24_2407 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF24_2411 ENOG41085GJ domain protein BF24_2413 ENOG4105DWV Homoserine O-trans-acetylase BF24_2415 ENOG4108B31 Spore germination protein BF24_2421 ENOG410605W Major Facilitator BF24_2422 ENOG4107S91 Sodium hydrogen exchanger BF24_2423 ENOG4105NCW Trka-c domain protein BF24_2426 ENOG4105C19 ABC transporter BF24_2430 ENOG4105N5T Radical SAM Protein BF24_2432 ENOG4105DA5 (ABC) transporter BF24_2438 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF24_2439 ENOG4108Z0R Transferase BF24_2440 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF24_2441 ENOG4105BZF Glycosyl transferase (Group 1 BF24_2443 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF24_2453 ENOG4105EGD dinuclear metal center protein, YbgI family BF24_2454 ENOG4105BZU Histidine kinase BF24_2455 ENOG4105BZU Histidine kinase BF24_2456 ENOG4107S9D Alpha beta hydrolase BF24_2457 ENOG4107T7U Sulfatase BF24_246 ENOG4105PKS Excinuclease abc c subunit domain protein BF24_2460 ENOG4105D2X ABC transporter substrate-binding protein BF24_2462 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF24_2466 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF24_2473 ENOG4108V2W Carbonate dehydratase BF24_2475 ENOG4105C4M (Ubiquinol oxidase) subunit I BF24_2476 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF24_2485 ENOG41087YS Phage shock protein A BF24_2492 ENOG4105BZU Histidine kinase BF24_2493 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_2498 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF24_2499 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF24_2506 ENOG4107ZTW SNARE associated Golgi BF24_2509 ENOG4105C19 ABC transporter BF24_2510 ENOG41086D8 Transcriptional regulator BF24_2521 ENOG4105C6Z Gluconate BF24_2522 ENOG4105FDP GntR family transcriptional regulator BF24_2526 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF24_2532 ENOG4105DTQ mandelate racemase muconate lactonizing BF24_2534 ENOG4108IPT Naphthoate synthase BF24_2535 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF24_2536 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF24_2537 ENOG4105E4F Isochorismate synthase BF24_2538 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF24_254 ENOG4107VFR oxidoreductase BF24_2540 ENOG4105VEQ Cold shock protein BF24_2545 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF24_2547 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF24_2549 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF24_2562 ENOG4105KT7 mgtC SapB transporter BF24_2564 ENOG4107PBV potassium channel BF24_2565 ENOG4107QYV phosphohexose isomerase BF24_2566 ENOG4105WG9 Conserved Protein BF24_2568 ENOG4105CHM Aminotransferase BF24_2569 ENOG4108ZB6 transcriptional regulator AsnC family BF24_2570 ENOG4105C5I Dehydrogenase BF24_2571 ENOG4108MUZ hydrolase BF24_2573 ENOG4105C87 Aminotransferase class I and II BF24_2576 ENOG4105Y38 Kinase-associated protein B BF24_2578 ENOG4107R3E Citrate transporter BF24_2581 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF24_2582 ENOG4105KA0 thioesterase Superfamily protein BF24_2586 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF24_259 ENOG4105PAD Hydrolase BF24_2590 ENOG41069ER domain protein BF24_2593 ENOG4105CEP NADH dehydrogenase BF24_2599 ENOG4105EWC Purine nucleoside phosphorylase BF24_26 ENOG41088CC tellurite resistance protein tehB BF24_2602 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF24_2606 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF24_2607 ENOG4105C4B ABC transporter, permease BF24_2608 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF24_2617 ENOG41083MR nifu domain-containing protein BF24_2620 ENOG4108W5N phosphatidylglycerophosphatase a BF24_2622 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF24_2623 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF24_2626 ENOG4105CBT Fructose-1,6-bisphosphatase BF24_2629 ENOG4105MMD transcriptional regulator BF24_2630 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF24_2631 ENOG4107TXC Transcriptional regulator BF24_2632 ENOG41090T1 Membrane BF24_2637 ENOG4105FAA peptidase M23 BF24_2639 ENOG4105KZD Domain of unknown function (DUF1805) BF24_264 ENOG4105DY8 decarboxylase BF24_2640 ENOG4107R8B 5'-nucleotidase BF24_2643 ENOG4105DIW FeS assembly protein SUFB BF24_2644 ENOG4108UNV SUF system FeS assembly protein, NifU family BF24_2645 ENOG4105C9B Cysteine desulfurase BF24_2646 ENOG4105JRK feS assembly protein SufD BF24_2647 ENOG4105C3K feS assembly ATPase SufC BF24_2648 ENOG4105D01 (LipO)protein BF24_2649 ENOG4105D01 (LipO)protein BF24_2650 ENOG4108UMI ABC transporter, permease BF24_2656 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF24_2665 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF24_267 ENOG4108IUM Glycogen debranching enzyme BF24_2671 ENOG4108W8B Beta-lactamase domain protein BF24_2672 ENOG4105C1G acyl-Coa dehydrogenase BF24_2673 ENOG4105CHU acetyl-coa acetyltransferase BF24_2676 ENOG4105DZ1 carboxypeptidase BF24_2680 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF24_2684 ENOG4108SUT Major Facilitator Superfamily BF24_2685 ENOG4107R7I amino acid BF24_2687 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF24_2689 ENOG4107AYK membrAne BF24_2696 ENOG4107ZTW SNARE associated Golgi BF24_2698 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF24_2699 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_2700 ENOG4105BZU Histidine kinase BF24_2702 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BF24_2705 ENOG4105VG1 fes assembly suf system protein BF24_2706 ENOG4105D4Y metalloprotease BF24_2710 ENOG4107S91 Sodium hydrogen exchanger BF24_2711 ENOG4105NCW Trka-c domain protein BF24_2713 ENOG4108RMU ferritin dps family protein BF24_2716 ENOG4108URH decarboxylase BF24_272 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF24_2721 ENOG4105D9N nucleoside BF24_2722 ENOG4105D9N nucleoside BF24_2725 ENOG4108RYK Nad-dependent epimerase dehydratase BF24_2730 ENOG4105CV8 reductase BF24_2731 ENOG4105F27 Major Facilitator BF24_2732 ENOG4105KVH Transcriptional regulator BF24_2735 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF24_2736 ENOG4105D4A Cell wall formation (By similarity) BF24_2738 ENOG4105C8Q Methyl-accepting chemotaxis BF24_274 ENOG4105FDR Membrane BF24_2740 ENOG4105WMR Protein CrcB homolog BF24_2741 ENOG4105WMR Protein CrcB homolog BF24_2744 ENOG4108MK9 spermidine N(1)-acetyltransferase BF24_2745 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF24_2748 ENOG4108IPW abc transporter atp-binding protein BF24_2749 ENOG4105CM4 permease protein BF24_2754 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF24_2756 ENOG4105XZU Preprotein translocase, subunit SecG BF24_2757 ENOG41067MG lrgb family BF24_2776 ENOG4105EFC phage portal protein HK97 family BF24_2781 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF24_2783 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF24_2784 ENOG4105CP7 Triose-phosphate isomerase BF24_2789 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_2793 ENOG41090VF Stage v sporulation protein ac BF24_2794 ENOG4105CZ3 stage V sporulation protein ad BF24_2797 ENOG4105H67 Protein of unknown function (DUF421) BF24_2798 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF24_2799 ENOG4105KRI phosphocarrier protein (HPr BF24_28 ENOG4108I0C methyltransferase BF24_2801 ENOG4105CHW UPF0052 protein BF24_2803 ENOG4108Z4K mutator MutT protein BF24_2805 ENOG4105C3M thioredoxin reductase BF24_2807 ENOG4108S4C acetyltransferase BF24_281 ENOG4108V3A UPF0421 protein BF24_2811 ENOG41086DT Membrane protein of unknown function BF24_2813 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF24_2814 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF24_2815 ENOG4105D7V transposase BF24_2818 ENOG4107TXC Transcriptional regulator BF24_2822 ENOG4105HMI Membrane BF24_2823 ENOG4105DUM transcriptional regulator, lysR family BF24_2825 ENOG4108WS4 fmn reductase BF24_2828 ENOG4105BZ1 (ABC) transporter BF24_2830 ENOG4105CN1 protease BF24_2831 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF24_2832 ENOG4105CAK Cell division ATP-binding protein ftsE BF24_2834 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF24_2835 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF24_2836 ENOG4105MS2 ribosomal subunit Interface protein BF24_2837 ENOG4105VEQ Cold shock protein BF24_2838 ENOG41081UC Inherit from COG: Competence protein BF24_2841 ENOG4105KVH Transcriptional regulator BF24_2843 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF24_2844 ENOG4108KGH TRANSCRIPTIONal BF24_2845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF24_2848 ENOG4105CMR udp-glucose 4-epimerase BF24_2849 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_285 ENOG4105MSI germination protein ypeb BF24_2850 ENOG4105BZU Histidine kinase BF24_2853 ENOG4105CXY transporter BF24_2857 ENOG4105C19 ABC transporter BF24_2858 ENOG4107RBB ABC transporter, permease BF24_2860 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_2866 ENOG4105C0D helicase BF24_2867 ENOG4105KBK Zinc finger, swim domain protein BF24_2872 ENOG41069ER domain protein BF24_2873 ENOG4105C94 Transporter BF24_2875 ENOG4107R8N Glycosyl transferase, family 2 BF24_2881 ENOG4105E0M Sulfatase BF24_2884 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF24_2886 ENOG4105DAA L-lactate BF24_289 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BF24_2894 ENOG4107RSM transcriptional regulator BF24_2895 ENOG4105ECB domain protein BF24_2896 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_2899 ENOG4105VZJ PTS System BF24_29 ENOG4107RA9 decarboxylase BF24_290 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BF24_2901 ENOG4105VCP PTS System BF24_2902 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF24_2903 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF24_2905 ENOG4105CK1 PTS System BF24_2906 ENOG4105VCP PTS System BF24_2907 ENOG4105F8D glycoside hydrolase family 4 BF24_2908 ENOG410901P UPF0249 protein BF24_291 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BF24_2911 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF24_2913 ENOG4105ESV Glycosyl transferase, family 4 BF24_2914 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF24_2915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF24_2916 ENOG4105EY8 ABC transporter BF24_292 ENOG4107Z3H Transcriptional regulator, TetR family BF24_2927 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF24_2929 ENOG4105FRN stage II sporulation protein BF24_2932 ENOG4105DY9 regulatoR BF24_2933 ENOG4108IUW ABC transporter BF24_2937 ENOG4106778 Protein of unknown function (DUF1146) BF24_2938 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF24_2939 ENOG4105C8S subunit m BF24_2940 ENOG4105D65 subunit l BF24_2945 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF24_2946 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF24_2948 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF24_2949 ENOG4105BZU Histidine kinase BF24_2959 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF24_2960 ENOG41062M3 atp synthase BF24_2965 ENOG4108YZG isomerase BF24_2968 ENOG4108VGI doxx family BF24_2969 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF24_2972 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF24_2974 ENOG4108ZXQ stage ii sporulation protein r BF24_2975 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF24_2976 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF24_2979 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF24_298 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF24_2980 ENOG4105CBT Fructose-1,6-bisphosphatase BF24_2981 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF24_2988 ENOG4105C1G acyl-Coa dehydrogenase BF24_2989 ENOG4105C1G acyl-Coa dehydrogenase BF24_2990 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF24_2992 ENOG4105DF6 Fe-S oxidoreductase BF24_2995 ENOG4105BZU Histidine kinase BF24_30 ENOG41090HR transcriptional regulator BF24_3000 ENOG4105BZU Histidine kinase BF24_3001 ENOG4105KCT ABC transporter BF24_3002 ENOG4108M15 ABC transporter BF24_3003 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF24_3007 ENOG4105IIU Aminopeptidase BF24_3011 ENOG4105EMN RNA polymerase sigma factor BF24_3013 ENOG410684U Domain of unknown function (DUF1934) BF24_3017 ENOG4105CYW agmatinase BF24_3019 ENOG4105DXB Major Facilitator superfamily BF24_302 ENOG4105E98 transcriptional regulator DeoR family BF24_3020 ENOG4107SWG transcriptional regulator MERR family BF24_3021 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF24_3022 ENOG4105BZ4 penicillin-binding protein BF24_3023 ENOG4108XFG YwhD family BF24_3024 ENOG4108Z4T Peptidase M50 BF24_3025 ENOG41069HH 4-oxalocrotonate tautomerase BF24_3026 ENOG4105DCI Phosphohydrolase BF24_3027 ENOG4108MES Periplasmic binding protein BF24_3028 ENOG4105E0A ABC, transporter BF24_3029 ENOG4105EHG Permease protein BF24_3030 ENOG4105DQ5 transport system permease protein BF24_3031 ENOG4105DQ5 transport system permease protein BF24_3033 ENOG4108VCI transcription factor, rsfa family BF24_3036 ENOG4108IJ2 phosphate acetyltransferase BF24_3039 ENOG4108VKI Cell wall hydrolase BF24_3043 ENOG4107SVH Potassium channel protein BF24_3045 ENOG410667J hydrolase BF24_3046 ENOG4105VCH membrane BF24_3048 ENOG4108TU7 Inherit from COG: (ABC) transporter BF24_3049 ENOG4105CJ1 ABC, transporter BF24_3050 ENOG41090WU lipolytic protein G-D-S-L family BF24_3053 ENOG4105D6E homoserine dehydrogenase BF24_3058 ENOG4108Y4K DNA-binding transcriptional activator BF24_306 ENOG41062ES Transcriptional regulator BF24_3060 ENOG4105WH1 Two component transcriptional regulator luxr family BF24_3061 ENOG4105BZU Histidine kinase BF24_3062 ENOG4105BZU Histidine kinase BF24_3063 ENOG4105DWF phosphomethylpyrimidine kinase BF24_3064 ENOG4105BZU Histidine kinase BF24_3065 ENOG4105VCD cytoplasmic protein BF24_3066 ENOG4105D22 carbon starvation protein BF24_3067 ENOG4105DY9 regulatoR BF24_3068 ENOG41079KZ Major Facilitator Superfamily BF24_3072 ENOG4105EN6 Membrane BF24_3073 ENOG4106YBV Methyl-accepting chemotaxis BF24_3075 ENOG4108S4H thioesterase Superfamily protein BF24_3077 ENOG4105JEU Glycosyl transferase, family 2 BF24_3078 ENOG4105C5H ABC transporter BF24_3083 ENOG4105CKK Glycosyl transferase, family 2 BF24_3084 ENOG41067SE Tetr family transcriptional regulator BF24_3086 ENOG4105E0X reductase BF24_3087 ENOG4106F5Q Membrane BF24_3090 ENOG4105DY9 regulatoR BF24_3091 ENOG4108HRK Histidine kinase BF24_3092 ENOG4107RGD Major Facilitator superfamily BF24_3095 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF24_3097 ENOG4105IW1 AmiS UreI transporter BF24_3099 ENOG4105CMR udp-glucose 4-epimerase BF24_3100 ENOG4108UT2 hemolysin iii BF24_3102 ENOG4105C1J atp-dependent rna helicase BF24_3105 ENOG4105DPN Oligoendopeptidase f BF24_3109 ENOG4105C0H protease BF24_311 ENOG4107QKR Dehydrogenase BF24_3110 ENOG4105Q2H domain protein BF24_3113 ENOG4105BZU Histidine kinase BF24_3114 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_3120 ENOG4105CDU Replicative dna helicase BF24_3122 ENOG4105BZR domain protein BF24_3123 ENOG4108XMW Membrane BF24_3125 ENOG4108UUM single-stranded DNA-binding protein BF24_3127 ENOG4105C3G gtp-binding protein BF24_3128 ENOG4105VDK protein, conserved in bacteria BF24_3129 ENOG4105D8X mechanosensitive ion channel BF24_313 ENOG4107RUY (E1 component), alpha subunit BF24_3130 ENOG4108ZDA Sporulation protein YyaC BF24_3133 ENOG4107QJE Chromosome Partitioning Protein BF24_3137 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF24_3139 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF24_3143 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF24_3144 ENOG410848D S4 domain protein YaaA BF24_3147 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF24_315 ENOG4105E1F short-chain dehydrogenase reductase BF24_3155 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF24_316 ENOG4105RHY Pfam:UPF0157 BF24_3162 ENOG4105ZMH deoxynucleoside kinase BF24_3164 ENOG4105GTG Isochorismatase BF24_3165 ENOG4108Z6B deaminase BF24_3166 ENOG4105C6E dna polymerase iii BF24_3170 ENOG41067KS pro-sigma K processing BF24_3178 ENOG4105CXN decarboxylase BF24_3180 ENOG4105FA2 dna polymerase iii BF24_3181 ENOG4105MA4 psp1 domain protein BF24_3183 ENOG41060K3 Methyltransferase BF24_3185 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF24_3186 ENOG4105KRN Transcriptional regulator, abrb family BF24_3188 ENOG4105F8V Hydrolase, tatD family BF24_3189 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF24_3191 ENOG4105XFA sporulation peptidase YabG BF24_3192 ENOG4105W42 Veg protein BF24_3195 ENOG4105DFT pur operon repressor BF24_3196 ENOG4105KME endoribonuclease L-psp BF24_3199 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF24_3200 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF24_3202 ENOG4108JA2 transcriptioN-repair coupling factor BF24_3203 ENOG4108M14 stage v sporulation protein t BF24_3205 ENOG4108IY2 MazG family BF24_3206 ENOG41082I2 s4 domain protein BF24_3207 ENOG4105VYY sporulation protein yabp BF24_3210 ENOG41060GV RNA binding s1 domain protein BF24_3214 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF24_3215 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF24_3216 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF24_3219 ENOG4105C6T cysteine synthase BF24_322 ENOG4107SQ8 Glycine betaine BF24_3220 ENOG4105CRQ synthase (Component I) BF24_3221 ENOG4105DDQ anthranilate synthase BF24_3222 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF24_3223 ENOG4105EEI dihydropteroate synthase BF24_3224 ENOG4105KRF dihydroneopterin aldolase BF24_3225 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF24_3227 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF24_323 ENOG4108IJ7 Glycine betaine BF24_3234 ENOG4108Z0C Uvrb UvrC protein BF24_3237 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF24_3239 ENOG4105CTP PilT protein domain protein BF24_3243 ENOG4105D7W serine acetyltransferase BF24_3246 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF24_3247 ENOG4105M0M Tetracycline resistance protein BF24_3248 ENOG4105QIV RNA polymerase BF24_3250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF24_3255 ENOG4107Y49 methyltransferase BF24_3257 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF24_3258 ENOG4105XPM ribosomal protein BF24_3279 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF24_328 ENOG4105E66 phosphoriboisomerase A BF24_3284 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF24_3286 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF24_3288 ENOG41067V7 50S ribosomal protein L36 BF24_329 ENOG41082BV acetyltransferase BF24_3294 ENOG4108JJB ABC transporter BF24_3295 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF24_3296 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF24_330 ENOG4108M1A Chitin-binding protein BF24_3301 ENOG4105D1F ATP-binding protein BF24_3304 ENOG4108NMV polysaccharide deacetylase BF24_3322 ENOG4105C8B TIGR00159 family BF24_3323 ENOG4107U5W ybbr family BF24_3325 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF24_3326 ENOG4108VQT Alpha beta hydrolase fold protein BF24_3328 ENOG4105CMG Carbohydrate kinase BF24_3329 ENOG4105CMG Carbohydrate kinase BF24_3331 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF24_3332 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF24_3340 ENOG4108PSK reductase BF24_3341 ENOG4108UMI ABC transporter, permease BF24_3342 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF24_3343 ENOG4105D01 (LipO)protein BF24_3344 ENOG4105EE1 crotonyl-CoA reductase BF24_3346 ENOG4105IQ5 FAD linked oxidase domain protein BF24_3349 ENOG4105C2C drug resistance transporter, Bcr CflA BF24_3352 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF24_3353 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF24_3354 ENOG4105C3U ABC transporter BF24_3355 ENOG4108JQ7 (ABC) transporter BF24_3361 ENOG4108J59 Extracellular solute-binding protein, family 5 BF24_3362 ENOG4108J59 Extracellular solute-binding protein, family 5 BF24_3364 ENOG4105II7 pyrroline-5-carboxylate reductase BF24_3365 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF24_3367 ENOG4105E0C molybdate abc transporter BF24_3368 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF24_3369 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF24_3370 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF24_3373 ENOG4105EGI Transcriptional regulator BF24_3377 ENOG4105F6E Acyl-transferase BF24_3381 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF24_3384 ENOG4108RE7 deoxyribonuclease BF24_3385 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF24_3389 ENOG4105C5H ABC transporter BF24_339 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF24_3392 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF24_3394 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF24_3395 ENOG4105C3U ABC transporter BF24_3396 ENOG4108JQ7 (ABC) transporter BF24_3397 ENOG410667J hydrolase BF24_3404 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF24_3405 ENOG4105ERH Fumarylacetoacetate hydrolase BF24_3407 ENOG4108SC4 )-transporter BF24_3408 ENOG4105CPF Cell wall formation (By similarity) BF24_3409 ENOG4105CPF Cell wall formation (By similarity) BF24_3410 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF24_3412 ENOG4107ZXI Rhomboid family BF24_3415 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF24_3416 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF24_3418 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF24_3443 ENOG4105K8N protein family UPF0079, ATPase BF24_3444 ENOG41072GX Peptidase M22 Glycoprotease BF24_3445 ENOG410801F ribosomal-protein-alanine acetyltransferase BF24_3446 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF24_3447 ENOG4105C5H ABC transporter BF24_3450 ENOG4108TYN CAAX amino terminal protease family protein BF24_3454 ENOG4105C7N Xanthine uracil vitamin C permease BF24_3456 ENOG4105BZU Histidine kinase BF24_3464 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF24_3470 ENOG4108SHN Glycosyl transferase, family 2 BF24_3475 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF24_3479 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_3483 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF24_3484 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF24_3485 ENOG4105C83 adenylosuccinate lyase BF24_3487 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF24_3492 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF24_3494 ENOG4105C12 Phosphoribosylglycinamide synthetase BF24_3499 ENOG4105C4R Atp-dependent dna helicase BF24_350 ENOG4105EEM helicase BF24_3505 ENOG4108W2Y isochorismatase BF24_3506 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF24_3507 ENOG4108UMI ABC transporter, permease BF24_3508 ENOG4105D01 (LipO)protein BF24_3512 ENOG4105D0U Arsenite-activated ATPase (ArsA) BF24_3513 ENOG410834F Transcriptional regulator BF24_3518 ENOG4105CBD Diacylglycerol kinase BF24_3519 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF24_3520 ENOG4108JPW Aminotransferase BF24_3522 ENOG4105C26 Dehydrogenase BF24_3523 ENOG4105KPY Small multidrug resistance protein BF24_3527 ENOG4105D9N nucleoside BF24_3528 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF24_3531 ENOG4108W15 Protein of unknown function (DUF1456) BF24_3534 ENOG4105DTQ mandelate racemase muconate lactonizing BF24_3535 ENOG4105DFD Na H antiporter BF24_354 ENOG4105C9U ATP-dependent DNA helicase RecQ BF24_3540 ENOG4105D3R alkyl hydroperoxide reductase BF24_3541 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF24_3543 ENOG4107W7X Aldolase BF24_3544 ENOG4105EHG Permease protein BF24_3545 ENOG4105DQ5 transport system permease protein BF24_3546 ENOG4108V5C ABC transporter BF24_3550 ENOG4106UIA BF24_3551 ENOG4106UIA BF24_3555 ENOG4105BZU Histidine kinase BF24_3559 ENOG410756H nucleotidyltransferase BF24_3560 ENOG4105D2S major facilitator superfamily BF24_3563 ENOG4105E5Q amino acid AbC transporter BF24_3564 ENOG4105EAB amino acid AbC transporter BF24_3566 ENOG4105C8Q Methyl-accepting chemotaxis BF24_3567 ENOG4105C8Q Methyl-accepting chemotaxis BF24_3569 ENOG4105CI1 PTS System BF24_3575 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF24_3578 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component BF24_3581 ENOG4105C5H ABC transporter BF24_3586 ENOG41062JF Transcriptional regulator BF24_3590 ENOG4105DEU major facilitator superfamily BF24_3593 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BF24_3596 ENOG4108N0M stress protein BF24_3597 ENOG4106FN3 tellurium resistance protein BF24_3598 ENOG4106FN3 tellurium resistance protein BF24_3599 ENOG4107TS3 membrane protein, TerC BF24_3600 ENOG4108TTB tellurium resistance protein BF24_3604 ENOG4105KJF protein tyrosine phosphatase BF24_3606 ENOG4107U9T Pfam:Ribonuclease_BN BF24_3607 ENOG4105C59 p-type ATPase BF24_3608 ENOG4108IPJ Membrane BF24_3610 ENOG4105C3F Signal peptidase i BF24_3613 ENOG4107ZTW SNARE associated Golgi BF24_3616 ENOG410606W general stress protein BF24_3617 ENOG4105UPD Calcium Proton BF24_3625 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF24_3626 ENOG4105VTR Integrase BF24_363 ENOG4108M1A Chitin-binding protein BF24_367 ENOG4105BZG amino acid carrier protein BF24_368 ENOG4105C26 Dehydrogenase BF24_3684 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF24_3686 ENOG4108JUB Transcriptional regulator BF24_3688 ENOG4108IQI permease BF24_369 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF24_3694 ENOG4105CSV Glutaminase BF24_3696 ENOG4108A04 Beta-lactamase BF24_3699 ENOG4105CKK Glycosyl transferase, family 2 BF24_370 ENOG4105CTU Proline racemase BF24_3701 ENOG4107QQG Dehydrogenase BF24_3702 ENOG4105C3I Nad-dependent epimerase dehydratase BF24_3705 ENOG4105F1A Pyruvate formate-lyase BF24_3709 ENOG4105CI2 imidazolone-5-propionate hydrolase BF24_371 ENOG4105CTU Proline racemase BF24_3710 ENOG4105ECP epimerase BF24_3716 ENOG41067AE Membrane-bound metal-dependent hydrolase BF24_3717 ENOG4105CEN a g-specific adenine glycosylase BF24_3718 ENOG4106BXE BF24_372 ENOG41080HI glycine oxidase BF24_3722 ENOG4105BZ1 (ABC) transporter BF24_3723 ENOG4107NBY Membrane BF24_3724 ENOG4105CBC glutamate synthase BF24_3726 ENOG4108IUW ABC transporter BF24_3730 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF24_3731 ENOG4105G5W regulator Fur family BF24_3753 ENOG4108JQC penicillin-binding protein 1A BF24_3754 ENOG4107ZQN disulfide bond BF24_3756 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF24_3758 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF24_3759 ENOG4105BZU Histidine kinase BF24_3761 ENOG4105CYN Serine protein kinase BF24_3765 ENOG4105C94 Transporter BF24_3768 ENOG4105DZ6 Band 7 protein BF24_3770 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF24_3771 ENOG4108MRH transcriptional regulatory protein BF24_3772 ENOG4105D4T Citrate transporter BF24_3776 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF24_3777 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF24_3778 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF24_3779 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF24_3780 ENOG4105BZ7 extracellular solute-binding protein family 1 BF24_3781 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF24_3782 ENOG4108STX response regulator BF24_3783 ENOG4105US7 Histidine kinase BF24_3788 ENOG4108MRH transcriptional regulatory protein BF24_3790 ENOG4105C6K Malic enzyme BF24_3792 ENOG4108UZ3 Transporter BF24_3793 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF24_3795 ENOG4105BZU Histidine kinase BF24_3796 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_3798 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF24_3799 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF24_38 ENOG4105CIN aminoacyl-histidine dipeptidase BF24_380 ENOG4107T5V SNARE associated Golgi BF24_3800 ENOG4108JB9 formate dehydrogenase BF24_3805 ENOG4105CUB amino acid BF24_3807 ENOG4105C59 p-type ATPase BF24_3808 ENOG4105DAP Nicotinate phosphoribosyltransferase BF24_3815 ENOG41073R8 VanW family BF24_3816 ENOG4108KGH TRANSCRIPTIONal BF24_3817 ENOG4105D9N nucleoside BF24_3818 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF24_3819 ENOG4105C37 (CBS) domain BF24_3820 ENOG4108IJ0 Aspartate ammonia-lyase BF24_3821 ENOG4105DAA L-lactate BF24_3824 ENOG4105DUX Transporter BF24_3825 ENOG4108MES Periplasmic binding protein BF24_3826 ENOG4105DQ5 transport system permease protein BF24_3827 ENOG4108IHU transport system permease protein BF24_3828 ENOG4105E0A ABC, transporter BF24_3829 ENOG4105DMQ Methyltransferase BF24_383 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF24_3831 ENOG4105EXW epimerase dehydratase BF24_3833 ENOG4107T89 von Willebrand factor, type A BF24_3834 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF24_3835 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF24_3838 ENOG4105BZU Histidine kinase BF24_3839 ENOG4105D5Q Arginine ornithine antiporter BF24_384 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF24_3840 ENOG4107414 GntR family transcriptional regulator BF24_3841 ENOG4105C5Y PTS System BF24_3842 ENOG4105CG3 alpha amylase, catalytic region BF24_3845 ENOG4105E1K spore germination protein BF24_3847 ENOG4105CRN Aminoglycoside phosphotransferase BF24_3848 ENOG4105BZG amino acid carrier protein BF24_3849 ENOG4105CDA abc transporter atp-binding protein BF24_3850 ENOG4105CT1 (ABC) transporter BF24_3851 ENOG4105EAD ABC transporter BF24_3852 ENOG4105DRP amino acid AbC transporter BF24_3853 ENOG4108IQI permease BF24_3858 ENOG4105D29 Helix-turn-helix type 11 domain protein BF24_3859 ENOG4105NAE bifunctional deaminase-reductase domain protein BF24_3860 ENOG4105BZU Histidine kinase BF24_3863 ENOG4105CHH sulfate transporter BF24_3864 ENOG41068KF Universal stress protein BF24_3866 ENOG4105DEF Extracellular solute-binding protein, family 5 BF24_3868 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF24_3869 ENOG4108JQ7 (ABC) transporter BF24_387 ENOG4105DTQ mandelate racemase muconate lactonizing BF24_3871 ENOG4105CXY transporter BF24_3872 ENOG41067TZ transcriptional regulator, MarR family BF24_3873 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_3874 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_3875 ENOG4105ETE Transcriptional regulator (LacI family BF24_3876 ENOG4108RVA ribokinase BF24_3878 ENOG4105C2J ABC transporter BF24_3879 ENOG4105CNN ABC, transporter BF24_3880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF24_3881 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF24_3893 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF24_3894 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF24_3895 ENOG41069ER domain protein BF24_3896 ENOG4105VZ8 Transcriptional regulator BF24_3897 ENOG4107D63 BF24_3899 ENOG4105DUX Transporter BF24_3903 ENOG4105C85 amino acid BF24_3904 ENOG4105C7N Xanthine uracil vitamin C permease BF24_3912 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF24_3913 ENOG4105E2S oxidase) subunit II BF24_3916 ENOG4106CAD Protein of unknown function (DUF3311) BF24_3917 ENOG4105E1V na solute symporter BF24_3920 ENOG4108NHD germination protein BF24_3921 ENOG4105CE1 Ferrous iron transport protein b BF24_3922 ENOG4105CE1 Ferrous iron transport protein b BF24_3923 ENOG4105CE1 Ferrous iron transport protein b BF24_3924 ENOG4105CVA phosphate BF24_3925 ENOG4105C8U phosphate abc transporter BF24_3926 ENOG4105E2Z phosphate ABC transporter (Permease BF24_3935 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF24_395 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF24_3951 ENOG41080XQ Signal transduction protein with cbs domains BF24_3955 ENOG4105ETU transcriptional activator (TenA BF24_3957 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF24_3959 ENOG4108VEU Thiamine monophosphate synthase BF24_396 ENOG4105F3H Histidine kinase BF24_3960 ENOG41080HI glycine oxidase BF24_3963 ENOG4105D06 uba thif-type nad fad binding protein BF24_3964 ENOG4105DWF phosphomethylpyrimidine kinase BF24_397 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_3973 ENOG4108INS Transcriptional regulator BF24_3976 ENOG4105C7N Xanthine uracil vitamin C permease BF24_3983 ENOG4105C5Y PTS System BF24_3990 ENOG4108B31 Spore germination protein BF24_3995 ENOG4107Y03 Nitroreductase BF24_3996 ENOG4105ED1 spovr family BF24_4001 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF24_4002 ENOG4105XTG Pfam:DUF156 BF24_4003 ENOG4105VFE sira family BF24_4004 ENOG4107TPS domain protein BF24_4005 ENOG4105VFE sira family BF24_4007 ENOG41085GJ domain protein BF24_4009 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF24_4010 ENOG41087NI Sulfite exporter TauE/SafE BF24_4012 ENOG4108KGH TRANSCRIPTIONal BF24_4017 ENOG4105EMD TRANSCRIPTIONal BF24_4018 ENOG4105VCP PTS System BF24_4019 ENOG4105VZJ PTS System BF24_4023 ENOG41069ER domain protein BF24_4024 ENOG4107RBB ABC transporter, permease BF24_4025 ENOG4105C19 ABC transporter BF24_4031 ENOG4105WEF catalase BF24_4038 ENOG4107T5V SNARE associated Golgi BF24_404 ENOG4105DPN Oligoendopeptidase f BF24_4044 ENOG4105CUB amino acid BF24_4045 ENOG4107RWR Sodium hydrogen exchanger BF24_4047 ENOG4106KNT transcriptional regulator BF24_4054 ENOG4108PCN EamA-like transporter family BF24_4055 ENOG4108YXU transcriptional regulator AsnC family BF24_4057 ENOG4105KPY Small multidrug resistance protein BF24_4058 ENOG4105KPY Small multidrug resistance protein BF24_406 ENOG4105EPR degv family BF24_4063 ENOG4105NF4 modulator of drug activity BF24_4064 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF24_4065 ENOG4105E5W Transporter BF24_4067 ENOG4107RKG DJ-1/PfpI family BF24_4068 ENOG4105CH6 catalase BF24_4070 ENOG4105D5Q Arginine ornithine antiporter BF24_4071 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF24_4074 ENOG4105C26 Dehydrogenase BF24_4075 ENOG4105BZ1 (ABC) transporter BF24_4076 ENOG4105BZ1 (ABC) transporter BF24_4077 ENOG4105BZ1 (ABC) transporter BF24_4079 ENOG4105DRP amino acid AbC transporter BF24_4080 ENOG4105CDA abc transporter atp-binding protein BF24_4083 ENOG410839P BF24_4091 ENOG4107FQX Alpha-acetolactate decarboxylase BF24_4096 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF24_4098 ENOG4105D4P Coproporphyrinogen iii oxidase BF24_4101 ENOG4105CHH sulfate transporter BF24_4109 ENOG4106AKK s-layer domain-containing protein BF24_4111 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF24_4112 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF24_4115 ENOG4105CGU Enoyl-CoA hydratase BF24_4118 ENOG4105DER m42 family BF24_4122 ENOG4105CTU Proline racemase BF24_4130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF24_4133 ENOG4108JQ7 (ABC) transporter BF24_4139 ENOG4105CSH Transporter BF24_414 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF24_4141 ENOG4108MRH transcriptional regulatory protein BF24_415 ENOG4106K7D Major facilitator family transporter BF24_4150 ENOG4105CDU Replicative dna helicase BF24_4158 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_4168 ENOG4107P5I polyketide synthase BF24_4169 ENOG4108IG5 Transcriptional regulator BF24_4173 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF24_4177 ENOG4105CMT Dihydroxyacetone kinase BF24_4179 ENOG4105CMT Dihydroxyacetone kinase BF24_4180 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF24_4181 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF24_4186 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF24_419 ENOG4107BMA Transglycosylase associated protein BF24_4199 ENOG4105WN5 stage II sporulation protein BF24_4201 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF24_4203 ENOG4108MJI response regulator BF24_4204 ENOG4105BZU Histidine kinase BF24_4205 ENOG4105BZU Histidine kinase BF24_4210 ENOG4105K8R UPF0145 protein BF24_4216 ENOG4107VRP DNA repair exonuclease BF24_4217 ENOG4106D4I domain protein BF24_4218 ENOG4105D7V transposase BF24_422 ENOG41089UC methyltransferase, type 11 BF24_4221 ENOG4108IND Tetr family transcriptional regulator BF24_4222 ENOG4105EQ0 Major Facilitator superfamily BF24_4228 ENOG4108MUZ hydrolase BF24_4232 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF24_4235 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF24_4238 ENOG4105EMN RNA polymerase sigma factor BF24_4243 ENOG4105C57 major facilitator superfamily BF24_4244 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_4246 ENOG4105EEM helicase BF24_4247 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF24_4252 ENOG4105K59 histidine triad (HIT) protein BF24_4259 ENOG410905X membrane-flanked domain protein BF24_4261 ENOG4105CKV Membrane BF24_4271 ENOG410905X membrane-flanked domain protein BF24_4272 ENOG4105CKV Membrane BF24_4273 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF24_4274 ENOG4105BZ4 penicillin-binding protein BF24_4275 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF24_4277 ENOG4105C1Q protoporphyrinogen oxidase BF24_428 ENOG4105CHM Aminotransferase BF24_4282 ENOG4105NA0 Transcriptional regulator BF24_4285 ENOG4105ECB domain protein BF24_4291 ENOG4106AXD BF24_4292 ENOG4108RQ5 Beta-lactamase domain-containing protein BF24_4293 ENOG4105DF9 Lipoate-protein, ligase BF24_4295 ENOG4105CEY Amp-dependent synthetase and ligase BF24_4301 ENOG4105CNA YD repeat protein BF24_4306 ENOG4105ENX hydrolase BF24_4308 ENOG4107RN3 metallophosphoesterase BF24_4309 ENOG4107TVP HD domain protein BF24_4311 ENOG4108AEY RNA polymerase sigma factor BF24_4312 ENOG41086D8 Transcriptional regulator BF24_4316 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_4321 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF24_4322 ENOG4105C8Q Methyl-accepting chemotaxis BF24_4326 ENOG4105ZU5 s-layer protein BF24_4327 ENOG4107QP3 malate synthase g BF24_4330 ENOG4105VEQ Cold shock protein BF24_4333 ENOG4105XVF Competence transcription factor BF24_4336 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF24_4337 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF24_434 ENOG4105DVE abc transporter atp-binding protein BF24_4345 ENOG4105ERH Fumarylacetoacetate hydrolase BF24_4350 ENOG4105CAQ asparagine synthetase BF24_4351 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF24_4352 ENOG4105CH6 catalase BF24_4353 ENOG4105BZU Histidine kinase BF24_4357 ENOG4105QNR S1 RNA binding domain protein BF24_4359 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF24_4361 ENOG4107AYK membrAne BF24_4362 ENOG41073B9 BF24_4364 ENOG4108KP7 hydrolase BF24_4366 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF24_4371 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF24_4372 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF24_4373 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF24_4376 ENOG4105C31 Tryptophanyl-tRNA synthetase BF24_4379 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF24_4380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF24_4382 ENOG4108JQ7 (ABC) transporter BF24_4383 ENOG4105UQX Mate efflux family protein BF24_4387 ENOG4108ZCF integral membrane protein BF24_4389 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF24_4392 ENOG4105DPN Oligoendopeptidase f BF24_4395 ENOG4108Z18 K06886 hemoglobin BF24_4396 ENOG4105MIX Adenylate cyclase BF24_4399 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF24_44 ENOG4107RF6 penicillin-binding protein BF24_4400 ENOG4105EMS pseudouridine synthase BF24_4404 ENOG4105CNI cell division protein FtsW BF24_4406 ENOG4105K64 Glycosyl transferase, family 2 BF24_4410 ENOG4107TVC Glycosyl transferase, family 2 BF24_4414 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF24_4415 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF24_4417 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF24_4426 ENOG4108WVJ 2'-5' rna ligase BF24_443 ENOG4105C02 permease BF24_4431 ENOG4105CK7 Sodium proline symporter BF24_4432 ENOG4105CRQ synthase (Component I) BF24_4433 ENOG4105DDQ anthranilate synthase BF24_445 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF24_4451 ENOG4105C7S Dehydrogenase BF24_4453 ENOG4105VZ8 Transcriptional regulator BF24_446 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF24_4464 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF24_4466 ENOG4105DZ1 carboxypeptidase BF24_4467 ENOG4105VFR signal peptidase BF24_447 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF24_4473 ENOG4105C26 Dehydrogenase BF24_4474 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF24_4475 ENOG4105F38 ABC transporter, permease BF24_4476 ENOG4105D38 putrescine abc transporter BF24_4477 ENOG4107RUE extracellular solute-binding protein family 1 BF24_4479 ENOG4105EYF MMPL domain protein BF24_4481 ENOG4108YBP pseudouridine synthase BF24_4483 ENOG4105K4I Scp-like extracellular BF24_4484 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF24_4485 ENOG4105CQB FAD linked oxidase domain protein BF24_4488 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_4489 ENOG4105BZU Histidine kinase BF24_4490 ENOG4105JXH GntR family transcriptional regulator BF24_4494 ENOG4106A3R peptidase BF24_4496 ENOG4108QTI )-transporter BF24_4497 ENOG4107TS3 membrane protein, TerC BF24_45 ENOG4107RF6 penicillin-binding protein BF24_4500 ENOG410681C small acid-soluble spore protein BF24_4501 ENOG4108Z7G MaoC domain protein dehydratase BF24_4505 ENOG4105CHR reductase BF24_4507 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF24_4511 ENOG4105C4Y ABC transporter BF24_4513 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF24_4516 ENOG4107RCV ABC transporter, permease BF24_4517 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF24_452 ENOG4105E09 nadh pyrophosphatase BF24_4520 ENOG4105E98 transcriptional regulator DeoR family BF24_4525 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF24_4526 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF24_4528 ENOG4105PXI polysaccharide deacetylase BF24_4530 ENOG4105BZU Histidine kinase BF24_4531 ENOG41090MY MarR family Transcriptional regulator BF24_4533 ENOG4106DF1 BF24_4535 ENOG4105BZU Histidine kinase BF24_4537 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF24_4538 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF24_4546 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF24_4547 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF24_4549 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF24_4550 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF24_4551 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF24_4552 ENOG4105CZV ABC transporter BF24_4554 ENOG4105CJ1 ABC, transporter BF24_456 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF24_4562 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF24_4563 ENOG4105EA8 2-Nitropropane dioxygenase BF24_4564 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF24_4566 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF24_4571 ENOG4105NQC Flavodoxin BF24_4578 ENOG4107QMU Mate efflux family protein BF24_4579 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF24_4585 ENOG4105CZN Potassium uptake protein BF24_4586 ENOG41063Y9 BF24_4587 ENOG4105KBJ sporulation protein ytfj BF24_4592 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF24_4593 ENOG4105C7K acetolactate synthase BF24_4594 ENOG4108ZP8 Acetolactate synthase small subunit BF24_4595 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF24_4597 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF24_46 ENOG4107RF6 penicillin-binding protein BF24_4603 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BF24_4610 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF24_4613 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF24_4614 ENOG4105E0M Sulfatase BF24_4616 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF24_4620 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF24_4621 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF24_4623 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF24_4624 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF24_4625 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF24_4626 ENOG4105C8J )-transporter BF24_4630 ENOG4105DFD Na H antiporter BF24_4634 ENOG4105ENE Histidine kinase BF24_4635 ENOG4105WH1 Two component transcriptional regulator luxr family BF24_4639 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF24_4644 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BF24_4648 ENOG4105CJ3 phosphate transporter BF24_4649 ENOG4107GRR phosphate transport regulator BF24_4650 ENOG4105BZ4 penicillin-binding protein BF24_4653 ENOG4105BZU Histidine kinase BF24_4654 ENOG4105I3N Conserved Protein BF24_4657 ENOG4105BZU Histidine kinase BF24_4664 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF24_4665 ENOG4105DZ1 carboxypeptidase BF24_4666 ENOG4108JIC nucleoside recognition domain protein BF24_4668 ENOG4105FE9 pseudouridine synthase BF24_467 ENOG4107VC0 DNA alkylation repair enzyme BF24_4670 ENOG4107TWT Cytochrome c biogenesis protein BF24_4671 ENOG4105CRE cytochrome C BF24_4672 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_4673 ENOG4105BZU Histidine kinase BF24_4674 ENOG4108WBT adenosyltransferase BF24_4677 ENOG4108SAX Membrane BF24_4679 ENOG4105T7X BF24_4680 ENOG4105C9U ATP-dependent DNA helicase RecQ BF24_4681 ENOG4105I7S Abortive infection protein BF24_4683 ENOG4107RGJ metallophosphoesterase BF24_4684 ENOG4107X2D transcriptional regulator, merr family BF24_4685 ENOG4108S6Z Negative regulator of genetic competence BF24_469 ENOG4107VMI polysaccharide deacetylase BF24_4690 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF24_4691 ENOG4107RB3 L-asparaginase BF24_4698 ENOG4105S2F BF24_4699 ENOG41065D1 BF24_4705 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF24_4708 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF24_471 ENOG4108ZCF integral membrane protein BF24_4710 ENOG4105EAH synthase BF24_4714 ENOG4105CIH Imidazole acetol-phosphate transaminase BF24_4715 ENOG41068YB TPR repeat-containing protein BF24_4718 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF24_4719 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF24_472 ENOG4105E0M Sulfatase BF24_4720 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF24_4726 ENOG4108JYZ YitT family BF24_4727 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF24_473 ENOG4105C5H ABC transporter BF24_4730 ENOG4105FJR Lmbe family BF24_4731 ENOG4105CPK Glycosyl transferase (Group 1 BF24_4738 ENOG4105DVT helicase BF24_4739 ENOG4105YAC BF24_4743 ENOG4105CSM endonuclease III BF24_4745 ENOG4105BZ4 penicillin-binding protein BF24_4746 ENOG4105BZ4 penicillin-binding protein BF24_475 ENOG4105EYF MMPL domain protein BF24_4757 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF24_4759 ENOG4105DVT helicase BF24_476 ENOG4105EYF MMPL domain protein BF24_4760 ENOG4105CTD carboxy-peptidase BF24_4763 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF24_4765 ENOG4105C2W permease BF24_4766 ENOG4105DHF Membrane BF24_4768 ENOG410890F Dynamin family BF24_477 ENOG41082JN Transcriptional regulator BF24_4770 ENOG4108W0I acetyltransferase BF24_4772 ENOG4105KHC sulfurtransferase BF24_4775 ENOG4106032 Glutathionylspermidine synthase BF24_4789 ENOG4105CPK Glycosyl transferase (Group 1 BF24_4792 ENOG4108SZE gCN5-related N-acetyltransferase BF24_4796 ENOG41081VK Ribonuclease BF24_48 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF24_4809 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF24_481 ENOG4105CIH Imidazole acetol-phosphate transaminase BF24_4811 ENOG4107RWR Sodium hydrogen exchanger BF24_4812 ENOG4105CN5 Metallo-Beta-Lactamase BF24_4813 ENOG4108Z5V transcriptional regulator, merr family BF24_4815 ENOG4105H67 Protein of unknown function (DUF421) BF24_4816 ENOG41080C8 DUF218 domain BF24_482 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF24_4827 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF24_4829 ENOG4107R0U MotA TolQ exbB proton channel BF24_483 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF24_4830 ENOG4105ER2 Ompa motb domain protein BF24_4831 ENOG4107YTP response regulator receiver protein BF24_4832 ENOG4105CBS Chea signal transduction histidine kinase BF24_4833 ENOG4105CBS Chea signal transduction histidine kinase BF24_4834 ENOG4105DD5 Flagellar motor switch protein BF24_4837 ENOG4105BZU Histidine kinase BF24_4841 ENOG4105E1Q flagellar hook-associated protein BF24_4842 ENOG4105DTJ flagellar hook-associated protein BF24_4848 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF24_4849 ENOG4108ZC9 flagellar basal-body rod protein flgc BF24_4850 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF24_4851 ENOG4107U2N Flagellar M-ring protein BF24_4853 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF24_4860 ENOG4105BZE flagellar hook protein, FlgE BF24_4864 ENOG4107R88 Chemotaxis protein (CheV) BF24_4866 ENOG4105K64 Glycosyl transferase, family 2 BF24_4872 ENOG4107TVC Glycosyl transferase, family 2 BF24_4877 ENOG4105I03 Flagellin BF24_4878 ENOG4105E4C Lytic transglycosylase catalytic BF24_4879 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF24_4881 ENOG4105DD5 Flagellar motor switch protein BF24_4883 ENOG4105CN7 Flagellar biosynthetic protein FliP BF24_4884 ENOG4105VS8 Flagellar biosynthetic protein fliq BF24_4886 ENOG4105D00 flagellar biosynthetic protein flhB BF24_4887 ENOG4105D7B Flagellar biosynthesis protein flha BF24_4888 ENOG4105FZW flagellar biosynthesis regulator FlhF BF24_4889 ENOG4105KTQ flagellar basal-body rod protein BF24_4890 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF24_4895 ENOG4108RZE Tetr family transcriptional regulator BF24_4899 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF24_49 ENOG4105ETE Transcriptional regulator (LacI family BF24_4904 ENOG4105DUM transcriptional regulator, lysR family BF24_4905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF24_4906 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF24_4907 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF24_4908 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF24_4915 ENOG4105CVJ phosphoglycerate mutase BF24_492 ENOG41069ER domain protein BF24_4922 ENOG4105CAQ asparagine synthetase BF24_4926 ENOG4105PGM cation diffusion facilitator family transporter BF24_4928 ENOG4105DRR Transcriptional regulator, GntR family BF24_4929 ENOG4108UZ3 Transporter BF24_4930 ENOG4105CKI cobalamin synthesis protein BF24_4931 ENOG4108PJD permease BF24_4934 ENOG4105DFD Na H antiporter BF24_4935 ENOG4105C9Q fumarate hydratase class II BF24_4939 ENOG4107QJQ Mate efflux family protein BF24_494 ENOG4105EMN RNA polymerase sigma factor BF24_4940 ENOG4107QJQ Mate efflux family protein BF24_4941 ENOG4105EC3 peptidase S51, dipeptidase E BF24_4945 ENOG4107QIV Cytochrome c biogenesis protein BF24_4952 ENOG4106BRA Membrane BF24_4959 ENOG4105CJ1 ABC, transporter BF24_4963 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF24_4965 ENOG4108IJ0 Aspartate ammonia-lyase BF24_4966 ENOG4105C6K Malic enzyme BF24_4980 ENOG4105FVX BF24_4988 ENOG4105CSR polyphosphate kinase 2 BF24_4989 ENOG4105DXI Major Facilitator superfamily BF24_4990 ENOG4105DXI Major Facilitator superfamily BF24_4993 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF24_4996 ENOG4105EU0 Major facilitator Superfamily BF24_4997 ENOG4105C6T cysteine synthase BF24_50 ENOG4105IE8 Alpha-ketoglutarate permease BF24_500 ENOG4105D4B ABC, transporter BF24_5002 ENOG4105C8J )-transporter BF24_5004 ENOG4105X5K response regulator receiver protein BF24_5005 ENOG4105H67 Protein of unknown function (DUF421) BF24_5008 ENOG4106KE4 Dehydrogenase BF24_5012 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF24_5013 ENOG4105CHR reductase BF24_5014 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF24_5015 ENOG4105C7K acetolactate synthase BF24_5016 ENOG4108ZP8 Acetolactate synthase small subunit BF24_5017 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF24_5019 ENOG4105C7B Threonine dehydratase BF24_502 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF24_5024 ENOG4105C6X Major Facilitator BF24_5025 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF24_5027 ENOG4105DY9 regulatoR BF24_5028 ENOG4105CYC Transferase BF24_5033 ENOG4105F6J Alpha beta hydrolase fold BF24_5034 ENOG4108J59 Extracellular solute-binding protein, family 5 BF24_504 ENOG4105DKT Transcriptional regulator BF24_5040 ENOG41068WN BF24_5045 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF24_5046 ENOG4105C72 UPF0176 protein BF24_5048 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF24_505 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF24_5050 ENOG4105C0X amino acid BF24_5051 ENOG4105C0X amino acid BF24_5056 ENOG4107RHR regulatoR BF24_5058 ENOG4105D9N nucleoside BF24_5059 ENOG4105D9N nucleoside BF24_5060 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF24_5066 ENOG4107RAQ aminopeptidase BF24_5067 ENOG4107STQ Multicopper oxidase BF24_5077 ENOG4108T5E Copper resistance protein BF24_5078 ENOG4105KTB nuclear export factor GLE1 BF24_508 ENOG41061GT Aldolase BF24_5080 ENOG4107RT3 EamA-like transporter family BF24_5081 ENOG4105GZI Transcriptional regulator BF24_5082 ENOG4108Z40 Transcriptional regulator BF24_5083 ENOG4107ZXU DSBA oxidoreductase BF24_5084 ENOG4108TVJ Nitroreductase BF24_5086 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF24_5087 ENOG4106F5Q Membrane BF24_5088 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF24_5090 ENOG4105CKI cobalamin synthesis protein BF24_5094 ENOG4108Z7G MaoC domain protein dehydratase BF24_5095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF24_5097 ENOG4105C0Z ABC transporter BF24_5098 ENOG4108IV0 ABC, transporter BF24_5099 ENOG4105C32 Amino acid ABC transporter (Permease) BF24_51 ENOG4105CK5 oxidoreductase BF24_5101 ENOG4105SKE transcriptional Regulator LysR family BF24_5105 ENOG4105YGB Transcriptional regulator BF24_5107 ENOG4105C4M (Ubiquinol oxidase) subunit I BF24_5108 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF24_5109 ENOG4108JJ9 ABC, transporter BF24_5110 ENOG4108JJ8 (ABC) transporter BF24_5118 ENOG4105BZ1 (ABC) transporter BF24_5119 ENOG4105BZ1 (ABC) transporter BF24_512 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF24_5120 ENOG4105EFI regulatoR BF24_5121 ENOG4105BZU Histidine kinase BF24_5124 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF24_5125 ENOG4108ZJ4 polysaccharide deacetylase BF24_5129 ENOG4105D6E homoserine dehydrogenase BF24_5134 ENOG4108KGH TRANSCRIPTIONal BF24_5136 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF24_5137 ENOG4105BZU Histidine kinase BF24_5138 ENOG4107VMI polysaccharide deacetylase BF24_5140 ENOG4105KT7 mgtC SapB transporter BF24_5141 ENOG4105VRR gCN5-related N-acetyltransferase BF24_5143 ENOG4105DUU IucA IucC family protein BF24_5144 ENOG4105CEY Amp-dependent synthetase and ligase BF24_5147 ENOG4108WBH protein TIM barrel BF24_5148 ENOG4105YWU small acid-soluble spore protein BF24_5149 ENOG4107RCC Major Facilitator Superfamily BF24_5151 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF24_5162 ENOG4105KRN Transcriptional regulator, abrb family BF24_5164 ENOG4105YVS arsR family transcriptional regulator BF24_5165 ENOG4107SET aldo keto reductase BF24_5166 ENOG4107XZQ multidrug resistance protein BF24_5171 ENOG4105C8Q Methyl-accepting chemotaxis BF24_5174 ENOG4108K88 Membrane BF24_5175 ENOG4108WPJ Ferritin-like domain BF24_5178 ENOG4105DEN Luciferase family BF24_518 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF24_5182 ENOG4107QM2 Aldo Keto reductase BF24_5183 ENOG4105CKI cobalamin synthesis protein BF24_519 ENOG4105II7 pyrroline-5-carboxylate reductase BF24_5194 ENOG4105DSE periplasmic solute binding protein BF24_5196 ENOG4105K4T epimerase BF24_5198 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF24_5204 ENOG4105CVJ phosphoglycerate mutase BF24_5208 ENOG4107T5V SNARE associated Golgi BF24_521 ENOG4107258 Transcriptional regulator BF24_5211 ENOG4108PJD permease BF24_5213 ENOG4108S4H thioesterase Superfamily protein BF24_5214 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF24_5218 ENOG4105SXS Protein of unknown function (DUF456) BF24_5219 ENOG4105C37 (CBS) domain BF24_5223 ENOG4108Z7R Chaperone CsaA BF24_5227 ENOG4108ZRV stage ii sporulation protein p BF24_5229 ENOG4108VXD carboxy-peptidase BF24_523 ENOG4105E0Y RtcB Protein BF24_5231 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF24_5236 ENOG4108X4Q Hydrolase BF24_5238 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF24_5239 ENOG4107RBS Methyltransferase BF24_524 ENOG4105ECK Fatty Acid Desaturase BF24_5242 ENOG41087PP glycosyltransferase MGT family BF24_5243 ENOG4108JYZ YitT family BF24_5244 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF24_525 ENOG4105G6Z alkaline phosphatase BF24_5250 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF24_5259 ENOG4105KBJ sporulation protein ytfj BF24_5264 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF24_5268 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF24_5269 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_527 ENOG4105VMP Transcriptional regulator BF24_5271 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF24_5272 ENOG4105EMN RNA polymerase sigma factor BF24_5277 ENOG4108V06 Glutathione peroxidase BF24_5280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF24_5284 ENOG4108IUE nitrate reductase beta subunit BF24_5285 ENOG4105R3A Nitrate reductase BF24_5290 ENOG4107V6Q Cyclic nucleotide-binding domain BF24_5291 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF24_5292 ENOG4105D06 uba thif-type nad fad binding protein BF24_5293 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF24_5294 ENOG4108ZAF Molybdopterin BF24_5299 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF24_530 ENOG41090T1 Membrane BF24_5300 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF24_5301 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF24_5302 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF24_5303 ENOG4108IFG nitrite reductase, (NAD(P)H) BF24_5304 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF24_5311 ENOG4105MCT stage V sporulation protein S BF24_5314 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF24_5318 ENOG4105C5H ABC transporter BF24_532 ENOG4108WCX response regulator BF24_5321 ENOG4108UUM single-stranded DNA-binding protein BF24_5324 ENOG41061H0 Monooxygenase BF24_5328 ENOG4107YX5 Pfam:DUF548 BF24_5329 ENOG4105C75 arginyL-tRNA synthetase BF24_5335 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF24_5338 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF24_5339 ENOG4105C5S asparaginyl-tRNA synthetase BF24_534 ENOG41068WN BF24_5362 ENOG4105BZW Glycerate kinase BF24_5363 ENOG4107QPK )-transporter BF24_5364 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_5365 ENOG41062D9 Histidine kinase BF24_5368 ENOG4105C8J )-transporter BF24_5372 ENOG4107XGZ Hydrolase BF24_5373 ENOG4105CY2 Citrate transporter BF24_5374 ENOG4105C0A alcohol dehydrogenase BF24_5377 ENOG4105KD7 acetyltransferase BF24_5379 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF24_5384 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF24_5388 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF24_539 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF24_5391 ENOG4107RVG penicillin-binding protein BF24_5392 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF24_5393 ENOG4105E9Q Acyl-transferase BF24_5394 ENOG4108UT2 hemolysin iii BF24_5396 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF24_5398 ENOG4108RCR degv family BF24_5399 ENOG4105E8R UPF0173 metal-dependent hydrolase BF24_5400 ENOG4108KF3 Electron transport protein SCO1 SenC BF24_5401 ENOG4107Y70 Heat shock protein BF24_5402 ENOG4105CAQ asparagine synthetase BF24_5406 ENOG4108MES Periplasmic binding protein BF24_5407 ENOG4105F0I Aminotransferase BF24_5414 ENOG4105D8X mechanosensitive ion channel BF24_5415 ENOG4105BZU Histidine kinase BF24_5416 ENOG4105WH1 Two component transcriptional regulator luxr family BF24_5418 ENOG4106KNT transcriptional regulator BF24_5426 ENOG4105CMG Carbohydrate kinase BF24_5427 ENOG4105CMG Carbohydrate kinase BF24_5433 ENOG4108IJ8 ABC transporter BF24_5434 ENOG4105E90 ABC transporter BF24_544 ENOG4105CKK Glycosyl transferase, family 2 BF24_5441 ENOG4105C37 (CBS) domain BF24_5446 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF24_5449 ENOG4107S4Y M20 DapE family protein YgeY BF24_5450 ENOG4108TSC N-acetyltransferase BF24_5451 ENOG4108JUB Transcriptional regulator BF24_5452 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF24_5460 ENOG4108N23 SpoOM-related protein BF24_5462 ENOG410841Q phosphoesterase PA-phosphatase related protein BF24_5463 ENOG4105SZ6 Thioredoxin BF24_5465 ENOG4108IBT Inherit from COG: transposase BF24_5484 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF24_549 ENOG4105CKK Glycosyl transferase, family 2 BF24_5492 ENOG4105BZ4 penicillin-binding protein BF24_5493 ENOG4105CZM Major Facilitator BF24_5494 ENOG4105W8X HesB YadR YfhF-family protein BF24_5496 ENOG4105DXD 2-methylcitrate dehydratase BF24_5497 ENOG4105CR4 methylisocitrate lyase BF24_5498 ENOG4105C1G acyl-Coa dehydrogenase BF24_5499 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF24_5501 ENOG4105N14 lysine exporter protein LysE YggA BF24_5502 ENOG4105E39 Enoyl-CoA hydratase BF24_5505 ENOG4107RFY SbcCD D subunit BF24_5506 ENOG4105EYH Exonuclease BF24_551 ENOG4105C8Y Acetylornithine aminotransferase BF24_5510 ENOG4105FCD Major Facilitator BF24_5511 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF24_5512 ENOG4105E4F Isochorismate synthase BF24_5513 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF24_5514 ENOG4105WQI isochorismatase BF24_5515 ENOG4105CEY Amp-dependent synthetase and ligase BF24_5516 ENOG4105WQT MbtH domain protein BF24_5517 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_5520 ENOG4105K70 DNA-binding protein BF24_5524 ENOG4105BZG amino acid carrier protein BF24_5528 ENOG4105FE9 pseudouridine synthase BF24_5529 ENOG4105C22 threonyL-tRNA synthetase BF24_5533 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF24_5539 ENOG4108D32 Methyltransferase BF24_5545 ENOG41081I9 integral membrane protein BF24_5548 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF24_5550 ENOG4105EYF MMPL domain protein BF24_5555 ENOG4105WCN acetyltransferase BF24_5561 ENOG4105C1Q protoporphyrinogen oxidase BF24_5563 ENOG41068WN BF24_5565 ENOG4105VEQ Cold shock protein BF24_5569 ENOG410667J hydrolase BF24_5577 ENOG4107V2S Transcriptional regulator BF24_5578 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF24_5581 ENOG4105DND Transcriptional regulator BF24_5582 ENOG4108RPX mosc domain containing protein BF24_5585 ENOG4105BZ1 (ABC) transporter BF24_5586 ENOG4105BZ1 (ABC) transporter BF24_5590 ENOG4108JCI Transcriptional regulator BF24_5599 ENOG4105DQ6 Transposase BF24_56 ENOG4105D2N Aldolase BF24_560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF24_5600 ENOG4105DQ6 Transposase BF24_5608 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF24_5614 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF24_562 ENOG4108TVJ Nitroreductase BF24_563 ENOG4105FS7 Transcriptional regulator BF24_5636 ENOG4105KRN Transcriptional regulator, abrb family BF24_5638 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF24_5645 ENOG4108IBT Inherit from COG: transposase BF24_5647 ENOG4105DQ6 Transposase BF24_5651 ENOG4105DQ6 Transposase BF24_5653 ENOG4105DQ6 Transposase BF24_5655 ENOG4108MEK Metal-binding protein YodA BF24_5657 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) BF24_5664 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF24_5685 ENOG4105EKQ RNA-directed DNA polymerase BF24_57 ENOG4105DH8 myo-inositol catabolism BF24_570 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF24_5706 ENOG4105EKQ RNA-directed DNA polymerase BF24_5718 ENOG4106JUT Streptomycin 3''-adenylyltransferase BF24_572 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF24_5734 ENOG4105CNU cell division protein FtsK BF24_578 ENOG4108XET gCN5-related N-acetyltransferase BF24_5784 ENOG4105DHF Membrane BF24_5790 ENOG4106AKK s-layer domain-containing protein BF24_5791 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF24_5795 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF24_5797 ENOG4105K4H Nlp p60 protein BF24_5810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF24_5811 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF24_5821 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF24_5824 ENOG4108J59 Extracellular solute-binding protein, family 5 BF24_5839 ENOG4105C3F Signal peptidase i BF24_5857 ENOG4105EWC Purine nucleoside phosphorylase BF24_5864 ENOG4105DQ6 Transposase BF24_5869 ENOG4107QJE Chromosome Partitioning Protein BF24_594 ENOG410635A Membrane BF24_595 ENOG4105KNA -acetyltransferase BF24_596 ENOG4108IQI permease BF24_598 ENOG4105F1N DNA alkylation repair BF24_606 ENOG4107RF6 penicillin-binding protein BF24_608 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF24_61 ENOG4105CGH 5'-nucleotidase BF24_615 ENOG4105P4J Allophanate hydrolase, subunit 1 BF24_616 ENOG4107258 Transcriptional regulator BF24_618 ENOG4106N3A copper homeostasis protein cutc BF24_619 ENOG4108ZRV stage ii sporulation protein p BF24_62 ENOG4105CGH 5'-nucleotidase BF24_620 ENOG4108ZHR arsR family transcriptional regulator BF24_622 ENOG4105FDT acyl-CoA dehydrogenase BF24_626 ENOG4105DWD nucleoside recognition domain protein BF24_632 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF24_647 ENOG4105E2A Dehydrogenase BF24_65 ENOG4105VZ8 Transcriptional regulator BF24_650 ENOG4108IJ0 Aspartate ammonia-lyase BF24_651 ENOG4105HDK L-asparaginase BF24_652 ENOG4108IMY Transcriptional regulator BF24_654 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF24_655 ENOG4105CUB amino acid BF24_657 ENOG4105II7 pyrroline-5-carboxylate reductase BF24_659 ENOG4105C6K Malic enzyme BF24_661 ENOG4108NHD germination protein BF24_662 ENOG4108NHD germination protein BF24_663 ENOG4108Q8B Spore germination protein BF24_669 ENOG4105CSV Glutaminase BF24_677 ENOG4105CGH 5'-nucleotidase BF24_678 ENOG4105CH6 catalase BF24_68 ENOG4108VXD carboxy-peptidase BF24_680 ENOG4105CHJ isochorismatase hydrolase BF24_686 ENOG41090MY MarR family Transcriptional regulator BF24_694 ENOG4108606 TspO/MBR family BF24_695 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF24_698 ENOG4108TWJ NADH dehydrogenase subunit 5 BF24_699 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF24_7 ENOG4105F32 YngK protein BF24_701 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF24_702 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF24_703 ENOG4105DSE periplasmic solute binding protein BF24_704 ENOG4105CC5 ABC transporter BF24_705 ENOG4105DIK (ABC) transporter BF24_711 ENOG4105D6J arsenicaL-resistance protein BF24_712 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_713 ENOG41085FC arsR family transcriptional regulator BF24_717 ENOG4105F7F Chaperone BF24_719 ENOG4105CHR reductase BF24_720 ENOG4108YXU transcriptional regulator AsnC family BF24_73 ENOG41067SE Tetr family transcriptional regulator BF24_734 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF24_735 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF24_737 ENOG4105IIP Membrane BF24_74 ENOG4105C5H ABC transporter BF24_740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF24_741 ENOG41062D9 Histidine kinase BF24_746 ENOG4105K6H D-cysteine desulfhydrase BF24_752 ENOG4105VZ8 Transcriptional regulator BF24_755 ENOG4108NNI Beta-lactamase domain-containing protein BF24_756 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF24_758 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF24_759 ENOG4105JQZ Methyltransferase BF24_76 ENOG4105BZU Histidine kinase BF24_762 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF24_763 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF24_766 ENOG4105BZU Histidine kinase BF24_769 ENOG4108U05 Transcriptional regulator BF24_770 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF24_772 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF24_773 ENOG4105DJB Major Facilitator Superfamily BF24_774 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF24_775 ENOG4107QR9 Iron-sulfur cluster binding protein BF24_777 ENOG4106P55 Transcriptional regulator BF24_779 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF24_78 ENOG4106ANW SMI1_KNR4 BF24_785 ENOG4105TRI Hydrolase BF24_79 ENOG4105CEP NADH dehydrogenase BF24_793 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF24_80 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF24_800 ENOG4107QJQ Mate efflux family protein BF24_803 ENOG4105MZU cell filamentation protein BF24_804 ENOG4105EQ0 Major Facilitator superfamily BF24_805 ENOG4108JGH Tetr family transcriptional regulator BF24_808 ENOG4105C44 Serine transporter BF24_809 ENOG4105EJQ L-serine dehydratase BF24_811 ENOG4108JPW Aminotransferase BF24_814 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF24_816 ENOG4105DVH amino acid BF24_819 ENOG4108JQ1 Dehydrogenase BF24_823 ENOG4108AEY RNA polymerase sigma factor BF24_826 ENOG41082W1 Cupin 2, conserved barrel domain protein BF24_827 ENOG410874W AraC family transcriptional regulator BF24_83 ENOG4105CJ1 ABC, transporter BF24_830 ENOG4105HIR S-layer domain protein BF24_838 ENOG4108ISG Major Facilitator BF24_840 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF24_841 ENOG4105CZM Major Facilitator BF24_845 ENOG4105DA5 (ABC) transporter BF24_846 ENOG41069JR BF24_848 ENOG4105RXJ BF24_849 ENOG4105KPY Small multidrug resistance protein BF24_85 ENOG4107Z3H Transcriptional regulator, TetR family BF24_850 ENOG4105KBX Transcriptional regulator, TetR family BF24_852 ENOG4105CRW Short chain fatty acid transporter BF24_854 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF24_860 ENOG4108JJB ABC transporter BF24_861 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF24_866 ENOG4108K8S endonuclease I BF24_869 ENOG41067QW Transcriptional regulator BF24_871 ENOG4108Z66 YbaK ebsC protein BF24_872 ENOG4105CUT histidyl-tRNA synthetase BF24_875 ENOG4105KVH Transcriptional regulator BF24_876 ENOG4108RCM Nitroreductase BF24_88 ENOG4105C1G acyl-Coa dehydrogenase BF24_880 ENOG4108PSK reductase BF24_882 ENOG4105CJ1 ABC, transporter BF24_89 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF24_894 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF24_895 ENOG4105DKQ ROK family BF24_896 ENOG4106UW1 Major Facilitator superfamily BF24_897 ENOG4108UW5 maltose o-acetyltransferase BF24_899 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF24_90 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF24_901 ENOG4105C31 Tryptophanyl-tRNA synthetase BF24_902 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF24_907 ENOG4105DMQ Methyltransferase BF24_909 ENOG4105EV4 Multidrug resistance protein mdtH BF24_91 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF24_915 ENOG4105C37 (CBS) domain BF24_918 ENOG4105DDN Pentapeptide repeat-containing protein BF24_919 ENOG4105XDF Protein of unknown function (DUF1272) BF24_92 ENOG4105E39 Enoyl-CoA hydratase BF24_920 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF24_921 ENOG4105CMG Carbohydrate kinase BF24_922 ENOG4105C6Z Gluconate BF24_923 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF24_926 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF24_927 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF24_928 ENOG4105CIS alcohol dehydrogenase BF24_929 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF24_93 ENOG4107QX3 carboxylase BF24_932 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF24_933 ENOG4105D4Y metalloprotease BF24_937 ENOG4105CV8 reductase BF24_938 ENOG4105F27 Major Facilitator BF24_94 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF24_941 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF24_942 ENOG4105C44 Serine transporter BF24_948 ENOG4105KVH Transcriptional regulator BF24_949 ENOG4108TZY GntR Family Transcriptional Regulator BF24_950 ENOG4105D9R oxidoreductase BF24_952 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF24_953 ENOG4105KVH Transcriptional regulator BF24_954 ENOG4105KVH Transcriptional regulator BF24_96 ENOG4105WCN acetyltransferase BF24_961 ENOG4105JAB phenazine biosynthesis protein, phzf family BF24_963 ENOG4105CHR reductase BF24_967 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF24_968 ENOG4105KVH Transcriptional regulator BF24_97 ENOG4105DBI uridine monophosphokinase BF24_972 ENOG4108ZJ4 polysaccharide deacetylase BF24_982 ENOG4105KAF membrAne BF24_987 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF24_991 ENOG4107YXZ hydrolase, family 25 BF24_996 ENOG4105ED2 Beta-lactamase BF24_998 ENOG4105H3G oxidoreductase