locus-tag	class	description
L6178_00010	COG0592	DNA-directed DNA polymerase activity
L6178_00015	COG2501	S4 domain
L6178_00025	COG0187	DNA topoisomerase II activity
L6178_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6178_00065	COG0516	GMP reductase activity
L6178_00065	COG0517	IMP dehydrogenase activity
L6178_00070	COG1686	Belongs to the peptidase S11 family
L6178_00100	COG1428	Deoxynucleoside kinase
L6178_00105	COG1428	Deoxynucleoside kinase
L6178_00110	COG1335	isochorismatase
L6178_00115	COG0590	tRNA wobble adenosine to inosine editing
L6178_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6178_00180	COG1982	Orn Lys Arg decarboxylase major
L6178_00190	COG0470	DNA polymerase III
L6178_00195	COG1774	PSP1 C-terminal conserved region
L6178_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6178_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6178_00220	COG2002	toxin-antitoxin pair type II binding
L6178_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_00230	COG0084	hydrolase, TatD family'
L6178_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6178_00250	COG4466	Protein conserved in bacteria
L6178_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6178_00270	COG0251	oxidation-reduction process
L6178_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6178_00305	COG2002	toxin-antitoxin pair type II binding
L6178_00310	COG2244	polysaccharide biosynthetic process
L6178_00315	COG3956	TIGRFAM MazG family protein
L6178_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6178_00340	COG1098	S1 RNA binding domain
L6178_00355	COG2208	phosphoserine phosphatase activity
L6178_00360	COG0037	tRNA processing
L6178_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6178_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6178_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6178_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6178_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6178_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6178_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6178_00420	COG1396	sequence-specific DNA binding
L6178_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6178_00455	COG3880	PFAM UvrB UvrC protein
L6178_00465	COG0542	response to heat
L6178_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6178_00480	COG4956	integral membrane protein (PIN domain superfamily)
L6178_00500	COG1045	serine acetyltransferase
L6178_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6178_00520	COG3688	RNA-binding protein containing a PIN domain
L6178_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6178_00540	COG0250	Participates in transcription elongation, termination and antitermination
L6178_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6178_00565	COG2813	Specifically methylates the guanine in position
L6178_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6178_00580	COG1358	cellular component organization or biogenesis
L6178_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
L6178_00710	COG0201	protein transport
L6178_00720	COG0024	Methionine aminopeptidase
L6178_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6178_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6178_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_00795	COG0489	protein tyrosine kinase activity
L6178_00805	COG2194	sulfuric ester hydrolase activity
L6178_00810	COG0726	polysaccharide deacetylase
L6178_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6178_00895	COG4856	YbbR-like protein
L6178_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6178_00915	COG0596	Alpha beta hydrolase
L6178_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6178_00940	COG4946	Tricorn protease homolog
L6178_00940	COG0823	Involved in the tonB-independent uptake of proteins
L6178_00940	COG1506	peptidase
L6178_00975	COG2011	ABC-type metal ion transport system permease component
L6178_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_00985	COG1464	Belongs to the NlpA lipoprotein family
L6178_00990	COG0604	alcohol dehydrogenase
L6178_01000	COG0277	FAD linked oxidase domain protein
L6178_01005	COG2271	Major facilitator Superfamily
L6178_01015	COG2814	Major facilitator Superfamily
L6178_01030	COG0601	transmembrane transport
L6178_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_01040	COG0444	Belongs to the ABC transporter superfamily
L6178_01045	COG4608	Belongs to the ABC transporter superfamily
L6178_01050	COG4166	transmembrane transport
L6178_01060	COG2207	Transcriptional regulator
L6178_01075	COG4166	transmembrane transport
L6178_01080	COG4166	transmembrane transport
L6178_01085	COG0656	L-ascorbic acid biosynthetic process
L6178_01105	COG4149	molybdate abc transporter
L6178_01115	COG1910	domain protein
L6178_01125	COG0583	DNA-binding transcription factor activity
L6178_01130	COG0697	spore germination
L6178_01145	COG0204	Acyl-transferase
L6178_01155	COG1609	Transcriptional regulator
L6178_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_01175	COG0084	hydrolase, TatD family'
L6178_01180	COG5298	Protein conserved in bacteria
L6178_01205	COG0488	(ABC) transporter
L6178_01220	COG0747	negative chemotaxis
L6178_01225	COG0601	transmembrane transport
L6178_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_01235	COG0444	Belongs to the ABC transporter superfamily
L6178_01260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6178_01265	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6178_01275	COG2814	Major facilitator Superfamily
L6178_01285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6178_01295	COG4294	response to UV
L6178_01300	COG0705	Rhomboid family
L6178_01300	COG0457	Tetratricopeptide repeat
L6178_01310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6178_01315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6178_01320	COG0864	Transcriptional regulator
L6178_01325	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6178_01330	COG2183	response to ionizing radiation
L6178_01425	COG0802	atpase or kinase
L6178_01430	COG1214	PFAM Peptidase M22, glycoprotease
L6178_01435	COG0456	acetyltransferase
L6178_01460	COG1266	CAAX protease self-immunity
L6178_01480	COG2252	PERMEase
L6178_01490	COG5002	protein histidine kinase activity
L6178_01520	COG2226	methyltransferase
L6178_01565	COG1968	undecaprenyl-diphosphatase activity
L6178_01580	COG2205	protein histidine kinase activity
L6178_01585	COG0745	RESPONSE REGULATOR receiver
L6178_01610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6178_01615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6178_01620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6178_01630	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6178_01645	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6178_01655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6178_01665	COG0151	Belongs to the GarS family
L6178_01690	COG0210	DNA helicase
L6178_01700	COG4851	CamS sex pheromone cAM373 precursor
L6178_01720	COG1335	isochorismatase
L6178_01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_01730	COG2011	ABC-type metal ion transport system permease component
L6178_01735	COG1464	Belongs to the NlpA lipoprotein family
L6178_01760	COG1846	Transcriptional regulator
L6178_01785	COG1597	lipid kinase activity
L6178_01790	COG0546	phosphoglycolate phosphatase activity
L6178_01795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6178_01805	COG1012	belongs to the aldehyde dehydrogenase family
L6178_01810	COG2076	Multidrug Resistance protein
L6178_01815	COG2309	aminopeptidase activity
L6178_01830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_01835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6178_01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6178_01850	COG4807	Protein conserved in bacteria
L6178_01875	COG1757	Na H antiporter
L6178_01880	COG1473	amidohydrolase
L6178_01895	COG0450	alkyl hydroperoxide reductase
L6178_01915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_01920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_01925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_01940	COG0166	Belongs to the GPI family
L6178_01975	COG5002	protein histidine kinase activity
L6178_01995	COG3541	Predicted nucleotidyltransferase
L6178_02000	COG2814	Major facilitator Superfamily
L6178_02005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_02005	COG0723	plastoquinol--plastocyanin reductase activity
L6178_02015	COG0765	amino acid transport
L6178_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_02030	COG0840	transmembrane signaling receptor activity
L6178_02035	COG0840	transmembrane signaling receptor activity
L6178_02040	COG0366	Alpha amylase catalytic
L6178_02045	COG1263	PTS System
L6178_02045	COG2190	(PTS) system
L6178_02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6178_02090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_02100	COG1116	anion transmembrane transporter activity
L6178_02105	COG0488	(ABC) transporter
L6178_02150	COG2270	Major facilitator Superfamily
L6178_02165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_02180	COG2310	stress, protein
L6178_02185	COG2310	stress, protein
L6178_02190	COG2310	stress, protein
L6178_02195	COG0861	Integral membrane protein TerC family
L6178_02205	COG3853	Toxic anion resistance protein (TelA)
L6178_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6178_02230	COG1295	ribonuclease BN
L6178_02235	COG2217	Heavy metal translocating P-type atpase
L6178_02240	COG0697	spore germination
L6178_02260	COG0586	Pfam SNARE associated Golgi protein
L6178_02275	COG3871	stress protein (general stress protein 26)
L6178_02280	COG0387	Pfam Sodium calcium exchanger
L6178_02290	COG0535	radical SAM domain protein
L6178_02315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6178_02320	COG0582	viral genome integration into host DNA
L6178_02330	COG1396	sequence-specific DNA binding
L6178_02345	COG1396	sequence-specific DNA binding
L6178_02380	COG1484	DNA-dependent DNA replication
L6178_02610	COG0101	tRNA pseudouridine synthase activity
L6178_02620	COG3829	transcription factor binding
L6178_02630	COG0833	amino acid
L6178_02635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6178_02665	COG1263	PTS System
L6178_02665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_02670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_02685	COG0463	Glycosyl transferase, family 2
L6178_02695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6178_02695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6178_02710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6178_02730	COG1228	amidohydrolase
L6178_02735	COG1090	epimerase
L6178_02765	COG1988	membrane-bound metal-dependent
L6178_02770	COG1194	a g-specific adenine glycosylase
L6178_02795	COG1132	(ABC) transporter
L6178_02800	COG4129	membrane
L6178_02805	COG0070	glutamate synthase
L6178_02805	COG0067	glutamate synthase
L6178_02805	COG0069	glutamate synthase activity
L6178_02815	COG4555	ABC transporter
L6178_02835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6178_02840	COG0735	belongs to the Fur family
L6178_02955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6178_02960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6178_02970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6178_02980	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6178_02990	COG2766	serine protein kinase
L6178_03010	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_03020	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6178_03025	COG2268	Band 7 protein
L6178_03035	COG3290	protein histidine kinase activity
L6178_03045	COG2851	Citrate transporter
L6178_03065	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6178_03070	COG3842	ATPase activity
L6178_03075	COG1175	transmembrane transport
L6178_03080	COG0395	ABC-type sugar transport system, permease component
L6178_03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6178_03095	COG0745	RESPONSE REGULATOR receiver
L6178_03100	COG5002	protein histidine kinase activity
L6178_03110	COG4990	cell redox homeostasis
L6178_03120	COG3290	protein histidine kinase activity
L6178_03125	COG4565	transcriptional regulatory protein
L6178_03130	COG3493	citrate carrier protein
L6178_03135	COG0281	malic enzyme
L6178_03150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_03160	COG5002	protein histidine kinase activity
L6178_03165	COG0745	RESPONSE REGULATOR receiver
L6178_03170	COG0456	acetyltransferase
L6178_03170	COG0454	-acetyltransferase
L6178_03175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6178_03180	COG3383	formate dehydrogenase (NAD+) activity
L6178_03200	COG0531	amino acid
L6178_03205	COG0640	Transcriptional regulator
L6178_03210	COG2217	Heavy metal translocating P-type atpase
L6178_03215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6178_03230	COG3227	Zinc metalloprotease (Elastase)
L6178_03250	COG2720	vancomycin resistance protein
L6178_03255	COG1316	TRANSCRIPTIONal
L6178_03260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_03265	COG0346	lactoylglutathione lyase activity
L6178_03275	COG1027	Aspartate ammonia-lyase
L6178_03280	COG1620	l-lactate permease
L6178_03295	COG3104	oligopeptide transport
L6178_03300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_03305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_03310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_03320	COG2226	methyltransferase
L6178_03325	COG0156	8-amino-7-oxononanoate synthase activity
L6178_03340	COG4548	von Willebrand factor, type A
L6178_03345	COG0714	Associated with various cellular activities
L6178_03350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_03370	COG0531	amino acid
L6178_03375	COG2188	Transcriptional regulator
L6178_03380	COG1263	PTS System
L6178_03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_03385	COG0366	Alpha amylase catalytic
L6178_03400	COG0697	spore germination
L6178_03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_03415	COG1115	amino acid carrier protein
L6178_03420	COG1126	abc transporter atp-binding protein
L6178_03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_03430	COG0765	amino acid transport
L6178_03435	COG0765	amino acid transport
L6178_03440	COG0833	amino acid
L6178_03465	COG2378	regulation of single-species biofilm formation
L6178_03470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6178_03475	COG5002	protein histidine kinase activity
L6178_03490	COG0659	secondary active sulfate transmembrane transporter activity
L6178_03505	COG0747	negative chemotaxis
L6178_03515	COG0601	transmembrane transport
L6178_03520	COG4608	Belongs to the ABC transporter superfamily
L6178_03530	COG2271	Major facilitator Superfamily
L6178_03535	COG1846	Transcriptional regulator
L6178_03545	COG1609	Transcriptional regulator
L6178_03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6178_03565	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6178_03570	COG1879	ABC-type sugar transport system periplasmic component
L6178_03595	COG1063	alcohol dehydrogenase
L6178_03610	COG3568	Endonuclease Exonuclease Phosphatase
L6178_03635	COG1968	undecaprenyl-diphosphatase activity
L6178_03640	COG0840	transmembrane signaling receptor activity
L6178_03645	COG1388	LysM domain
L6178_03645	COG3584	3D domain protein
L6178_03650	COG1476	TRANSCRIPTIONal
L6178_03665	COG3104	oligopeptide transport
L6178_03670	COG1114	Component of the transport system for branched-chain amino acids
L6178_03685	COG1113	amino acid transport
L6178_03690	COG2252	PERMEase
L6178_03715	COG0569	domain protein
L6178_03715	COG0475	glutathione-regulated potassium exporter activity
L6178_03730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6178_03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6178_03740	COG4990	cell redox homeostasis
L6178_03755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_03760	COG0697	spore germination
L6178_03765	COG0531	amino acid
L6178_03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6178_03785	COG1918	ferrous iron import across plasma membrane
L6178_03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6178_03795	COG0573	inorganic phosphate transmembrane transporter activity
L6178_03800	COG0581	inorganic phosphate transmembrane transporter activity
L6178_03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6178_03925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6178_03945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6178_03950	COG1116	anion transmembrane transporter activity
L6178_03955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_03960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_03965	COG0352	thiamine-phosphate diphosphorylase activity
L6178_03970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_03975	COG2104	thiamine diphosphate biosynthetic process
L6178_03985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_03990	COG0351	phosphomethylpyrimidine kinase
L6178_04030	COG2205	protein histidine kinase activity
L6178_04035	COG2814	Major facilitator Superfamily
L6178_04040	COG1846	Transcriptional regulator
L6178_04055	COG2252	PERMEase
L6178_04060	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_04075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6178_04080	COG1621	beta-fructofuranosidase activity
L6178_04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_04085	COG1263	PTS System
L6178_04090	COG1609	Transcriptional regulator
L6178_04100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_04105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6178_04140	COG0778	Nitroreductase
L6178_04145	COG2719	SpoVR family
L6178_04170	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6178_04175	COG1937	Protein conserved in bacteria
L6178_04180	COG0425	Belongs to the sulfur carrier protein TusA family
L6178_04180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_04185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_04190	COG0425	Belongs to the sulfur carrier protein TusA family
L6178_04205	COG2210	Belongs to the sulfur carrier protein TusA family
L6178_04210	COG0730	response to heat
L6178_04220	COG1316	TRANSCRIPTIONal
L6178_04225	COG0604	alcohol dehydrogenase
L6178_04230	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6178_04245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_04245	COG3711	transcriptional antiterminator
L6178_04250	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_04255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_04275	COG1388	LysM domain
L6178_04275	COG3584	3D domain protein
L6178_04280	COG0577	efflux transmembrane transporter activity
L6178_04285	COG1136	(ABC) transporter
L6178_04295	COG5522	Integral membrane protein (intg_mem_TP0381)
L6178_04310	COG1114	Component of the transport system for branched-chain amino acids
L6178_04315	COG3546	catalase activity
L6178_04350	COG0586	Pfam SNARE associated Golgi protein
L6178_04385	COG0531	amino acid
L6178_04390	COG0475	glutathione-regulated potassium exporter activity
L6178_04400	COG1737	Transcriptional regulator
L6178_04410	COG1263	PTS System
L6178_04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_04420	COG2259	Doxx family
L6178_04435	COG0697	spore germination
L6178_04440	COG1522	sequence-specific DNA binding
L6178_04455	COG2076	Multidrug Resistance protein
L6178_04460	COG1309	transcriptional regulator
L6178_04465	COG2814	Major facilitator Superfamily
L6178_04470	COG1733	regulation of RNA biosynthetic process
L6178_04480	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_04485	COG4533	DNA binding
L6178_04490	COG2211	Major facilitator Superfamily
L6178_04500	COG0693	protein deglycase activity
L6178_04505	COG0693	protein deglycase activity
L6178_04505	COG0753	catalase activity
L6178_04515	COG0531	amino acid
L6178_04520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6178_04530	COG1012	belongs to the aldehyde dehydrogenase family
L6178_04535	COG1132	(ABC) transporter
L6178_04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_04550	COG0765	amino acid transport
L6178_04555	COG1126	abc transporter atp-binding protein
L6178_04570	COG0189	ligase activity
L6178_04600	COG0028	Belongs to the TPP enzyme family
L6178_04605	COG3527	Alpha-acetolactate decarboxylase
L6178_04620	COG0561	phosphatase activity
L6178_04635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6178_04650	COG0659	secondary active sulfate transmembrane transporter activity
L6178_04670	COG0653	protein targeting
L6178_04675	COG2244	polysaccharide biosynthetic process
L6178_04685	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_04690	COG4196	transglutaminase domain protein
L6178_04705	COG1696	Membrane protein involved in D-alanine export
L6178_04720	COG1024	Enoyl-CoA hydratase
L6178_04740	COG1363	Peptidase, m42
L6178_04760	COG3938	Belongs to the proline racemase family
L6178_04800	COG0601	transmembrane transport
L6178_04805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_04815	COG4608	Belongs to the ABC transporter superfamily
L6178_04850	COG0477	Major facilitator Superfamily
L6178_04855	COG3290	protein histidine kinase activity
L6178_04860	COG4565	transcriptional regulatory protein
L6178_04865	COG3181	Tripartite tricarboxylate transporter family receptor
L6178_04895	COG0789	Transcriptional regulator
L6178_04895	COG4978	Transcriptional regulator
L6178_04910	COG0305	Participates in initiation and elongation during chromosome replication
L6178_04950	COG0477	Major facilitator Superfamily
L6178_04995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_04995	COG3320	Male sterility
L6178_05000	COG1309	transcriptional regulator
L6178_05020	COG1183	phosphatidylcholine synthase activity
L6178_05040	COG2376	Dihydroxyacetone kinase
L6178_05050	COG2376	Dihydroxyacetone kinase
L6178_05055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_05060	COG1959	2 iron, 2 sulfur cluster binding
L6178_05090	COG2770	Histidine kinase
L6178_05090	COG3437	response regulator, receiver
L6178_05145	COG3237	CsbD-like
L6178_05170	COG1191	sigma factor activity
L6178_05180	COG2208	phosphoserine phosphatase activity
L6178_05185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6178_05190	COG2198	Histidine kinase
L6178_05190	COG2205	protein histidine kinase activity
L6178_05190	COG0784	Response regulator, receiver
L6178_05190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_05245	COG0420	3'-5' exonuclease activity
L6178_05270	COG1309	transcriptional regulator
L6178_05275	COG2814	Major facilitator Superfamily
L6178_05280	COG0346	lactoylglutathione lyase activity
L6178_05285	COG0346	lactoylglutathione lyase activity
L6178_05290	COG0457	Tetratricopeptide repeat
L6178_05295	COG2267	carboxylic ester hydrolase activity
L6178_05315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6178_05320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6178_05330	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6178_05370	COG0477	Major facilitator Superfamily
L6178_05375	COG0477	Major facilitator Superfamily
L6178_05385	COG3973	AAA domain
L6178_05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_05410	COG4980	gas vesicle protein
L6178_05415	COG0537	adenosine 5'-monophosphoramidase activity
L6178_05420	COG1131	(ABC) transporter
L6178_05425	COG4473	ABC transporter
L6178_05440	COG1309	transcriptional regulator
L6178_05450	COG3402	PFAM membrane-flanked domain
L6178_05495	COG3402	PFAM membrane-flanked domain
L6178_05500	COG3428	Bacterial PH domain
L6178_05505	COG2329	Antibiotic biosynthesis monooxygenase
L6178_05510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6178_05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6178_05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6178_05560	COG1309	transcriptional regulator
L6178_05565	COG1511	domain protein
L6178_05590	COG1609	Transcriptional regulator
L6178_05600	COG1234	tRNA 3'-trailer cleavage
L6178_05605	COG0095	Lipoate-protein ligase
L6178_05615	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_05645	COG3209	COG3209 Rhs family protein
L6178_05685	COG1078	dGTPase activity
L6178_05695	COG1595	DNA-templated transcription, initiation
L6178_05700	COG3708	Transcriptional regulator
L6178_05700	COG2207	Transcriptional regulator
L6178_05715	COG2205	protein histidine kinase activity
L6178_05720	COG0745	RESPONSE REGULATOR receiver
L6178_05745	COG0501	Belongs to the peptidase M48B family
L6178_05750	COG0840	transmembrane signaling receptor activity
L6178_05755	COG0697	spore germination
L6178_05775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6178_05780	COG2224	Isocitrate lyase
L6178_05805	COG4903	ComK protein
L6178_05810	COG0398	Pfam SNARE associated Golgi protein
L6178_05820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L6178_05825	COG1074	ATP-dependent DNA helicase activity
L6178_05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6178_05895	COG0367	asparagine synthase
L6178_05900	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6178_05905	COG0753	catalase activity
L6178_05910	COG0004	ammonium transporteR
L6178_05930	COG2996	Protein conserved in bacteria
L6178_05940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_05950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_05965	COG0561	phosphatase activity
L6178_05975	COG0542	response to heat
L6178_05985	COG2267	carboxylic ester hydrolase activity
L6178_06000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_06005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6178_06010	COG5504	Zn-dependent protease
L6178_06020	COG0180	Tryptophanyl-tRNA synthetase
L6178_06030	COG4166	transmembrane transport
L6178_06035	COG0601	transmembrane transport
L6178_06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_06045	COG0444	Belongs to the ABC transporter superfamily
L6178_06050	COG4608	Belongs to the ABC transporter superfamily
L6178_06055	COG0534	Mate efflux family protein
L6178_06060	COG4166	transmembrane transport
L6178_06075	COG0861	Integral membrane protein TerC family
L6178_06080	COG4862	establishment of competence for transformation
L6178_06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_06095	COG1164	Oligoendopeptidase f
L6178_06105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6178_06110	COG2346	COG2346, Truncated hemoglobins
L6178_06115	COG4116	CYTH
L6178_06125	COG2357	RelA SpoT domain protein
L6178_06135	COG0564	pseudouridine synthase activity
L6178_06155	COG0463	Glycosyl transferase, family 2
L6178_06155	COG1216	Glycosyl transferase, family 2
L6178_06175	COG0463	Glycosyl transferase, family 2
L6178_06175	COG0457	Tetratricopeptide repeat
L6178_06195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6178_06210	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6178_06255	COG2153	protein acetylation
L6178_06265	COG2382	esterase
L6178_06280	COG5492	domain, Protein
L6178_06285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_06295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6178_06295	COG0512	Glutamine amidotransferase of anthranilate synthase
L6178_06330	COG1620	l-lactate permease
L6178_06335	COG5634	Uncharacterized conserved protein (DUF2278)
L6178_06390	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_06400	COG1476	TRANSCRIPTIONal
L6178_06460	COG2226	methyltransferase
L6178_06470	COG1686	Belongs to the peptidase S11 family
L6178_06475	COG0681	Belongs to the peptidase S26 family
L6178_06510	COG1012	belongs to the aldehyde dehydrogenase family
L6178_06515	COG3842	ATPase activity
L6178_06520	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6178_06525	COG1177	transmembrane transport
L6178_06530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6178_06540	COG2409	Drug exporters of the RND superfamily
L6178_06550	COG0564	pseudouridine synthase activity
L6178_06560	COG2340	Cysteine-rich secretory protein family
L6178_06565	COG0247	lactate metabolic process
L6178_06570	COG0277	FAD linked oxidase domain protein
L6178_06575	COG3835	regulator
L6178_06585	COG0745	RESPONSE REGULATOR receiver
L6178_06590	COG5002	protein histidine kinase activity
L6178_06595	COG2186	Transcriptional regulator
L6178_06615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6178_06625	COG2116	formate transmembrane transporter activity
L6178_06630	COG0861	Integral membrane protein TerC family
L6178_06635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_06645	COG2030	dehydratase
L6178_06665	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_06670	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6178_06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_06680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_06695	COG1840	ABC-type Fe3 transport system, periplasmic component
L6178_06725	COG1349	DNA-binding transcription factor activity
L6178_06745	COG2861	carbohydrate metabolic process
L6178_06755	COG3852	Histidine kinase
L6178_06760	COG1846	Transcriptional regulator
L6178_06770	COG2318	DinB family
L6178_06780	COG5002	protein histidine kinase activity
L6178_06790	COG0720	synthase
L6178_06805	COG4873	Protein conserved in bacteria
L6178_06835	COG1780	Probably involved in ribonucleotide reductase function
L6178_06855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6178_06860	COG1725	Transcriptional regulator
L6178_06865	COG1131	(ABC) transporter
L6178_06875	COG1131	(ABC) transporter
L6178_06880	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_06895	COG1522	sequence-specific DNA binding
L6178_06905	COG1335	isochorismatase
L6178_06915	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_06920	COG2070	2-Nitropropane dioxygenase
L6178_06925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6178_06935	COG1696	Membrane protein involved in D-alanine export
L6178_06960	COG0716	FMN binding
L6178_06975	COG3173	Aminoglycoside phosphotransferase
L6178_06995	COG0534	Mate efflux family protein
L6178_07000	COG1968	undecaprenyl-diphosphatase activity
L6178_07015	COG1846	Transcriptional regulator
L6178_07025	COG1301	dicarboxylic acid transport
L6178_07030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6178_07035	COG4709	membrane
L6178_07040	COG3874	Sporulation protein YtfJ
L6178_07065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_07070	COG0028	Belongs to the TPP enzyme family
L6178_07075	COG0440	acetolactate synthase activity
L6178_07080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6178_07090	COG0473	3-isopropylmalate dehydrogenase activity
L6178_07115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6178_07150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6178_07165	COG1183	phosphatidylcholine synthase activity
L6178_07170	COG1368	sulfuric ester hydrolase activity
L6178_07180	COG0019	diaminopimelate decarboxylase activity
L6178_07200	COG0529	Catalyzes the synthesis of activated sulfate
L6178_07205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6178_07225	COG1648	precorrin-2 dehydrogenase activity
L6178_07230	COG0733	neurotransmitter:sodium symporter activity
L6178_07250	COG1757	Na H antiporter
L6178_07265	COG4758	membrane
L6178_07270	COG4585	Histidine kinase
L6178_07275	COG2197	response regulator
L6178_07285	COG1114	Component of the transport system for branched-chain amino acids
L6178_07295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6178_07320	COG1017	nitric oxide dioxygenase activity
L6178_07320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6178_07335	COG0730	response to heat
L6178_07340	COG0306	phosphate transporter
L6178_07345	COG1392	Phosphate transport regulator
L6178_07350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_07365	COG3852	Histidine kinase
L6178_07370	COG1801	Protein of unknown function DUF72
L6178_07380	COG0582	viral genome integration into host DNA
L6178_07385	COG5002	protein histidine kinase activity
L6178_07405	COG0392	lysyltransferase activity
L6178_07405	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6178_07420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_07425	COG1686	Belongs to the peptidase S11 family
L6178_07430	COG2715	membrane protein required for spore maturation
L6178_07435	COG0700	Nucleoside recognition
L6178_07440	COG1187	pseudouridine synthase activity
L6178_07450	COG1333	cytochrome c biogenesis protein
L6178_07455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6178_07460	COG0745	RESPONSE REGULATOR receiver
L6178_07465	COG5002	protein histidine kinase activity
L6178_07470	COG2096	Adenosyltransferase
L6178_07485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6178_07490	COG1141	Ferredoxin
L6178_07495	COG4955	Helix-turn-helix domain
L6178_07500	COG0514	ATP-dependent DNA helicase (RecQ)
L6178_07505	COG1266	CAAX protease self-immunity
L6178_07525	COG4862	establishment of competence for transformation
L6178_07530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6178_07550	COG0492	ferredoxin-NADP+ reductase activity
L6178_07555	COG0252	asparaginase activity
L6178_07625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_07640	COG0142	geranyltranstransferase activity
L6178_07650	COG0142	geranyltranstransferase activity
L6178_07670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6178_07675	COG0457	Tetratricopeptide repeat
L6178_07695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6178_07705	COG4347	Protein of unknown function (DUF1405)
L6178_07720	COG2738	Putative neutral zinc metallopeptidase
L6178_07730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_07735	COG1694	Mazg nucleotide pyrophosphohydrolase
L6178_07750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_07755	COG0438	transferase activity, transferring glycosyl groups
L6178_07790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6178_07790	COG1199	ATP-dependent helicase activity
L6178_07810	COG3935	DnaD domain protein
L6178_07815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6178_07825	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6178_07825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_07885	COG0116	Belongs to the methyltransferase superfamily
L6178_07895	COG1199	ATP-dependent helicase activity
L6178_07900	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6178_07910	COG3173	Aminoglycoside phosphotransferase
L6178_07915	COG0024	Methionine aminopeptidase
L6178_07925	COG2233	PERMEase
L6178_07930	COG2311	Membrane
L6178_07935	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_07945	COG0456	acetyltransferase
L6178_07995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_08020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6178_08035	COG1215	transferase activity, transferring glycosyl groups
L6178_08040	COG0438	transferase activity, transferring glycosyl groups
L6178_08055	COG0454	-acetyltransferase
L6178_08075	COG0328	RNA-DNA hybrid ribonuclease activity
L6178_08115	COG1280	lysine exporter protein (LysE YggA)
L6178_08130	COG3162	membrane
L6178_08135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_08140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_08150	COG0475	glutathione-regulated potassium exporter activity
L6178_08155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6178_08160	COG0789	Transcriptional regulator
L6178_08160	COG4978	Transcriptional regulator
L6178_08170	COG2323	membrane
L6178_08175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6178_08230	COG1923	regulation of RNA biosynthetic process
L6178_08240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6178_08245	COG1360	Flagellar Motor Protein
L6178_08250	COG2201	protein-glutamate methylesterase activity
L6178_08260	COG1776	CheC inhibitor of MCP methylation
L6178_08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_08275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6178_08295	COG1256	bacterial-type flagellum assembly
L6178_08320	COG1815	bacterial-type flagellum-dependent cell motility
L6178_08325	COG1558	bacterial-type flagellum-dependent cell motility
L6178_08340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_08350	COG1157	protein secretion by the type III secretion system
L6178_08395	COG0463	Glycosyl transferase, family 2
L6178_08420	COG0463	Glycosyl transferase, family 2
L6178_08420	COG0457	Tetratricopeptide repeat
L6178_08435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6178_08440	COG0741	lytic transglycosylase activity
L6178_08455	COG1776	CheC inhibitor of MCP methylation
L6178_08455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6178_08465	COG1338	Plays a role in the flagellum-specific transport system
L6178_08470	COG1987	bacterial-type flagellum assembly
L6178_08480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6178_08485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6178_08495	COG4786	Flagellar basal body rod
L6178_08500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_08525	COG1309	transcriptional regulator
L6178_08545	COG2329	Antibiotic biosynthesis monooxygenase
L6178_08570	COG0583	DNA-binding transcription factor activity
L6178_08580	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6178_08590	COG1234	tRNA 3'-trailer cleavage
L6178_08615	COG1686	Belongs to the peptidase S11 family
L6178_08625	COG0406	alpha-ribazole phosphatase activity
L6178_08655	COG0367	asparagine synthase
L6178_08685	COG1802	Transcriptional regulator
L6178_08690	COG0697	spore germination
L6178_08695	COG0523	cobalamin synthesis protein
L6178_08700	COG0701	Predicted permease
L6178_08710	COG0438	transferase activity, transferring glycosyl groups
L6178_08710	COG1216	Glycosyl transferase, family 2
L6178_08715	COG1757	Na H antiporter
L6178_08720	COG0114	fumarate hydratase activity
L6178_08745	COG3340	Belongs to the peptidase S51 family
L6178_08765	COG0785	Cytochrome C biogenesis protein
L6178_08795	COG2733	membrane
L6178_08830	COG1131	(ABC) transporter
L6178_08845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_08850	COG0528	UMP kinase activity
L6178_08860	COG1027	Aspartate ammonia-lyase
L6178_08865	COG0281	malic enzyme
L6178_08870	COG4191	Histidine kinase
L6178_08875	COG0784	Response regulator, receiver
L6178_08880	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_08940	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_08950	COG2814	Major facilitator Superfamily
L6178_08965	COG1966	Carbon starvation protein
L6178_08980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_08990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6178_09000	COG2223	nitrite transmembrane transporter activity
L6178_09005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_09020	COG2244	polysaccharide biosynthetic process
L6178_09025	COG0733	neurotransmitter:sodium symporter activity
L6178_09035	COG5566	PFAM Mor transcription activator
L6178_09040	COG2323	membrane
L6178_09060	COG2084	Dehydrogenase
L6178_09075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_09085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_09090	COG0028	Belongs to the TPP enzyme family
L6178_09095	COG0440	acetolactate synthase activity
L6178_09100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6178_09110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6178_09135	COG2814	Major facilitator Superfamily
L6178_09140	COG3384	dioxygenase
L6178_09150	COG3279	Response regulator of the LytR AlgR family
L6178_09155	COG0427	acetyl-CoA hydrolase
L6178_09175	COG1073	alpha beta
L6178_09205	COG0535	radical SAM domain protein
L6178_09210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_09230	COG1914	H( )-stimulated, divalent metal cation uptake system
L6178_09245	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6178_09275	COG2390	Transcriptional regulator
L6178_09285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_09290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6178_09305	COG4224	UPF0291 protein
L6178_09325	COG0006	proline dipeptidase activity
L6178_09330	COG2132	Multicopper oxidase
L6178_09345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6178_09360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_09375	COG2372	response to copper ion
L6178_09375	COG1276	copper resistance
L6178_09380	COG4549	nuclear export factor GLE1
L6178_09390	COG0697	spore germination
L6178_09395	COG0583	DNA-binding transcription factor activity
L6178_09400	COG1959	2 iron, 2 sulfur cluster binding
L6178_09405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6178_09410	COG0778	Nitroreductase
L6178_09420	COG0628	permease
L6178_09430	COG1231	oxidoreductase activity
L6178_09435	COG0523	cobalamin synthesis protein
L6178_09450	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_09455	COG2030	dehydratase
L6178_09460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_09470	COG0411	ABC transporter
L6178_09490	COG0583	DNA-binding transcription factor activity
L6178_09500	COG1942	4-Oxalocrotonate Tautomerase
L6178_09510	COG1846	Transcriptional regulator
L6178_09520	COG1271	oxidase subunit
L6178_09525	COG1294	oxidase, subunit
L6178_09530	COG4988	ABC transporter
L6178_09535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6178_09555	COG1686	Belongs to the peptidase S11 family
L6178_09570	COG1388	LysM domain
L6178_09570	COG0791	NLP P60 protein
L6178_09585	COG0745	RESPONSE REGULATOR receiver
L6178_09590	COG5002	protein histidine kinase activity
L6178_09600	COG0300	oxidoreductase activity
L6178_09635	COG0460	homoserine dehydrogenase
L6178_09660	COG1316	TRANSCRIPTIONal
L6178_09670	COG0745	RESPONSE REGULATOR receiver
L6178_09675	COG5002	protein histidine kinase activity
L6178_09690	COG1285	pathogenesis
L6178_09695	COG1247	-acetyltransferase
L6178_09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_09725	COG1082	Xylose isomerase domain protein TIM barrel
L6178_09740	COG1279	arginine transmembrane transporter activity
L6178_09750	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6178_09790	COG2002	toxin-antitoxin pair type II binding
L6178_09795	COG1404	Belongs to the peptidase S8 family
L6178_09800	COG0640	Transcriptional regulator
L6178_09805	COG0667	Aldo Keto reductase
L6178_09810	COG2814	Major facilitator Superfamily
L6178_09835	COG0840	transmembrane signaling receptor activity
L6178_09850	COG3949	Membrane
L6178_09855	COG0783	Belongs to the Dps family
L6178_09870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_09880	COG1231	oxidoreductase activity
L6178_09890	COG4989	oxidoreductase activity
L6178_09895	COG0523	cobalamin synthesis protein
L6178_09900	COG0456	acetyltransferase
L6178_09960	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6178_09960	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6178_09970	COG0702	epimerase
L6178_09980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6178_09990	COG4166	transmembrane transport
L6178_10005	COG0406	alpha-ribazole phosphatase activity
L6178_10015	COG5337	Spore coat protein CotH
L6178_10020	COG1051	belongs to the nudix hydrolase family
L6178_10025	COG0586	Pfam SNARE associated Golgi protein
L6178_10030	COG2244	polysaccharide biosynthetic process
L6178_10040	COG0701	Predicted permease
L6178_10045	COG3689	TIGRFAM TIGR03943 family protein
L6178_10050	COG1607	acyl-coa hydrolase
L6178_10075	COG0702	epimerase
L6178_10080	COG2839	Protein conserved in bacteria
L6178_10085	COG1253	flavin adenine dinucleotide binding
L6178_10100	COG1114	Component of the transport system for branched-chain amino acids
L6178_10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_10125	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_10135	COG1876	peptidase activity
L6178_10145	COG0154	amidase activity
L6178_10150	COG2211	Major facilitator Superfamily
L6178_10170	COG0561	phosphatase activity
L6178_10180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6178_10185	COG4106	trans-aconitate 2-methyltransferase activity
L6178_10200	COG1819	glycosyl
L6178_10205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_10210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_10245	COG0456	acetyltransferase
L6178_10300	COG3874	Sporulation protein YtfJ
L6178_10325	COG2226	methyltransferase
L6178_10350	COG0346	lactoylglutathione lyase activity
L6178_10360	COG0604	alcohol dehydrogenase
L6178_10365	COG1595	DNA-templated transcription, initiation
L6178_10390	COG0386	Belongs to the glutathione peroxidase family
L6178_10395	COG1305	Transglutaminase-like
L6178_10400	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6178_10405	COG0714	Associated with various cellular activities
L6178_10420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6178_10425	COG1140	nitrate reductase beta subunit
L6178_10430	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6178_10435	COG2181	nitrate reductase activity
L6178_10455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6178_10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6178_10465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_10470	COG0303	'Molybdopterin
L6178_10475	COG0314	molybdopterin synthase activity
L6178_10485	COG2223	nitrite transmembrane transporter activity
L6178_10500	COG1648	precorrin-2 dehydrogenase activity
L6178_10510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6178_10510	COG1587	Uroporphyrinogen-III synthase
L6178_10515	COG2146	nitrite reductase [NAD(P)H] activity
L6178_10520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6178_10525	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6178_10560	COG2359	stage V sporulation protein S
L6178_10585	COG1418	mRNA catabolic process
L6178_10590	COG0488	(ABC) transporter
L6178_10605	COG0629	single-stranded DNA binding
L6178_10620	COG1413	lyase activity
L6178_10635	COG2136	Putative SAM-dependent methyltransferase
L6178_10635	COG2521	methyltransferase
L6178_10640	COG0018	arginyl-trna synthetase
L6178_10665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6178_10685	COG0017	Asparaginyl-tRNA synthetase
L6178_10705	COG1674	ftsk spoiiie
L6178_10775	COG1929	Belongs to the glycerate kinase type-1 family
L6178_10780	COG0471	metal ion transport
L6178_10785	COG0745	RESPONSE REGULATOR receiver
L6178_10790	COG5002	protein histidine kinase activity
L6178_10790	COG3850	Histidine kinase
L6178_10805	COG0733	neurotransmitter:sodium symporter activity
L6178_10830	COG2610	gluconate transmembrane transporter activity
L6178_10835	COG1454	alcohol dehydrogenase
L6178_10840	COG1794	racemase activity, acting on amino acids and derivatives
L6178_10850	COG0456	acetyltransferase
L6178_10865	COG1131	(ABC) transporter
L6178_10880	COG0546	phosphoglycolate phosphatase activity
L6178_10900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_10915	COG0768	penicillin binding
L6178_10920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6178_10925	COG0204	Acyl-transferase
L6178_10930	COG1272	protein, Hemolysin III
L6178_10940	COG0805	protein transport
L6178_10950	COG1307	EDD domain protein, DegV family
L6178_10955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6178_10960	COG1999	signal sequence binding
L6178_10965	COG0071	Belongs to the small heat shock protein (HSP20) family
L6178_10970	COG0367	asparagine synthase
L6178_10985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_10990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6178_11025	COG0668	transmembrane transport
L6178_11030	COG2203	Gaf domain
L6178_11030	COG4585	Histidine kinase
L6178_11035	COG2197	response regulator
L6178_11045	COG1064	alcohol dehydrogenase
L6178_11100	COG1125	glycine betaine transport
L6178_11100	COG0517	IMP dehydrogenase activity
L6178_11105	COG1174	glycine betaine transport
L6178_11140	COG1253	flavin adenine dinucleotide binding
L6178_11145	COG1012	belongs to the aldehyde dehydrogenase family
L6178_11150	COG5506	Protein of unknown function (DUF1694)
L6178_11165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_11170	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6178_11175	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6178_11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6178_11185	COG0456	acetyltransferase
L6178_11190	COG3829	transcription factor binding
L6178_11195	COG1509	lysine 2,3-aminomutase activity
L6178_11235	COG4326	sporulation control protein
L6178_11240	COG0671	phosphoesterase, PA-phosphatase related
L6178_11245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6178_11250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_11280	COG1715	Restriction endonuclease
L6178_11280	COG1787	Restriction endonuclease
L6178_11370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6178_11410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_11410	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6178_11420	COG2814	Major facilitator Superfamily
L6178_11425	COG4841	protein insertion into membrane
L6178_11430	COG0372	Belongs to the citrate synthase family
L6178_11435	COG2079	MmgE PrpD family protein
L6178_11440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6178_11445	COG1960	acyl-CoA dehydrogenase activity
L6178_11450	COG2084	Dehydrogenase
L6178_11460	COG1280	lysine exporter protein (LysE YggA)
L6178_11465	COG1024	Enoyl-CoA hydratase
L6178_11480	COG0420	3'-5' exonuclease activity
L6178_11485	COG0419	ATPase involved in DNA repair
L6178_11510	COG2223	nitrite transmembrane transporter activity
L6178_11515	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_11520	COG1169	isochorismate synthase
L6178_11525	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6178_11530	COG3433	isochorismatase activity
L6178_11530	COG1535	isochorismatase
L6178_11535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6178_11540	COG3251	PFAM MbtH domain protein
L6178_11545	COG2814	Major facilitator Superfamily
L6178_11560	COG0776	regulation of translation
L6178_11570	COG2318	DinB family
L6178_11580	COG1115	amino acid carrier protein
L6178_11595	COG2329	Antibiotic biosynthesis monooxygenase
L6178_11600	COG1187	pseudouridine synthase activity
L6178_11605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_11620	COG0596	Alpha beta hydrolase
L6178_11625	COG2814	Major facilitator Superfamily
L6178_11645	COG2226	methyltransferase
L6178_11690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_11725	COG1247	-acetyltransferase
L6178_11755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6178_11765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_11775	COG1278	Cold shock
L6178_11790	COG0010	Belongs to the arginase family
L6178_11795	COG0561	phosphatase activity
L6178_11840	COG0583	DNA-binding transcription factor activity
L6178_11845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6178_11860	COG0583	DNA-binding transcription factor activity
L6178_11865	COG2258	MOSC domain
L6178_11880	COG1132	(ABC) transporter
L6178_11885	COG1132	(ABC) transporter
L6178_11905	COG1396	sequence-specific DNA binding
L6178_11930	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6178_11935	COG1595	DNA-templated transcription, initiation
L6178_11960	COG1649	PFAM Uncharacterised BCR, COG1649
L6178_11985	COG2971	BadF BadG BcrA BcrD
L6178_11990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_11995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6178_12015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_12045	COG1309	transcriptional regulator
L6178_12060	COG0577	efflux transmembrane transporter activity
L6178_12060	COG1136	(ABC) transporter
L6178_12065	COG0500	methyltransferase
L6178_12065	COG3615	Tellurite resistance protein tehB
L6178_12075	COG2226	methyltransferase
L6178_12080	COG3961	Belongs to the TPP enzyme family
L6178_12085	COG1846	Transcriptional regulator
L6178_12125	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6178_12140	COG1595	DNA-templated transcription, initiation
L6178_12150	COG0768	penicillin binding
L6178_12160	COG2367	Beta-lactamase
L6178_12165	COG0671	phosphoesterase, PA-phosphatase related
L6178_12170	COG1609	Transcriptional regulator
L6178_12175	COG2814	Major facilitator Superfamily
L6178_12180	COG0673	inositol 2-dehydrogenase activity
L6178_12190	COG1012	belongs to the aldehyde dehydrogenase family
L6178_12205	COG0191	fructose-bisphosphate aldolase activity
L6178_12210	COG3718	enzyme involved in inositol metabolism
L6178_12235	COG0457	Tetratricopeptide repeat
L6178_12240	COG1476	TRANSCRIPTIONal
L6178_12255	COG1876	peptidase activity
L6178_12275	COG1309	transcriptional regulator
L6178_12280	COG0488	(ABC) transporter
L6178_12295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_12310	COG1252	NADH dehydrogenase
L6178_12315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_12330	COG1131	(ABC) transporter
L6178_12340	COG1309	transcriptional regulator
L6178_12355	COG1960	acyl-CoA dehydrogenase activity
L6178_12360	COG0439	Biotin carboxylase
L6178_12365	COG0511	ligase activity, forming carbon-carbon bonds
L6178_12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6178_12375	COG1024	Enoyl-CoA hydratase
L6178_12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6178_12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_12395	COG1247	-acetyltransferase
L6178_12400	COG0572	uridine kinase
L6178_12410	COG2318	DinB family
L6178_12415	COG1686	Belongs to the peptidase S11 family
L6178_12440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6178_12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_12505	COG2814	Major facilitator Superfamily
L6178_12525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_12560	COG1063	alcohol dehydrogenase
L6178_12575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_12580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_12595	COG3773	Cell wall hydrolase
L6178_12605	COG0745	RESPONSE REGULATOR receiver
L6178_12635	COG1136	(ABC) transporter
L6178_12660	COG0460	homoserine dehydrogenase
L6178_12665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_12675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6178_12740	COG2124	cytochrome p450
L6178_12775	COG0561	phosphatase activity
L6178_12785	COG0768	penicillin binding
L6178_12790	COG1819	glycosyl
L6178_12795	COG1794	racemase activity, acting on amino acids and derivatives
L6178_12805	COG1122	ATPase activity
L6178_12820	COG2205	protein histidine kinase activity
L6178_12830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_12835	COG0604	alcohol dehydrogenase
L6178_12840	COG0768	penicillin binding
L6178_12850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_12885	COG0693	protein deglycase activity
L6178_12915	COG2814	Major facilitator Superfamily
L6178_12930	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_12950	COG0697	spore germination
L6178_12980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_12990	COG2223	nitrite transmembrane transporter activity
L6178_13005	COG2816	NAD+ diphosphatase activity
L6178_13010	COG0592	DNA-directed DNA polymerase activity
L6178_13015	COG1051	belongs to the nudix hydrolase family
L6178_13050	COG3878	Protein conserved in bacteria
L6178_13100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6178_13115	COG0322	excinuclease ABC activity
L6178_13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_13185	COG1011	Hydrolase
L6178_13205	COG0076	glutamate decarboxylase activity
L6178_13220	COG1523	belongs to the glycosyl hydrolase 13 family
L6178_13225	COG3227	Zinc metalloprotease (Elastase)
L6178_13245	COG0201	protein transport
L6178_13255	COG0697	spore germination
L6178_13260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_13290	COG4129	membrane
L6178_13295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_13310	COG2959	enzyme of heme biosynthesis
L6178_13330	COG3483	tryptophan 2,3-dioxygenase activity
L6178_13335	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L6178_13340	COG3844	kynureninase activity
L6178_13345	COG1309	transcriptional regulator
L6178_13375	COG3284	Transcriptional regulator
L6178_13395	COG1349	DNA-binding transcription factor activity
L6178_13415	COG1959	2 iron, 2 sulfur cluster binding
L6178_13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6178_13435	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_13440	COG0022	dehydrogenase e1 component
L6178_13445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_13455	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_13460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_13460	COG0456	acetyltransferase
L6178_13490	COG4176	ABC-type proline glycine betaine transport system permease component
L6178_13495	COG0517	IMP dehydrogenase activity
L6178_13495	COG4175	Glycine betaine
L6178_13520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6178_13525	COG2153	protein acetylation
L6178_13530	COG3397	chitin binding
L6178_13545	COG2205	protein histidine kinase activity
L6178_13570	COG0658	competence protein
L6178_13570	COG2333	competence protein COMEC
L6178_13620	COG3973	AAA domain
L6178_13635	COG2105	PFAM AIG2 family protein
L6178_13640	COG0514	ATP-dependent DNA helicase (RecQ)
L6178_13660	COG4637	Psort location Cytoplasmic, score
L6178_13685	COG3397	chitin binding
L6178_13700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6178_13705	COG1115	amino acid carrier protein
L6178_13710	COG1012	belongs to the aldehyde dehydrogenase family
L6178_13715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6178_13725	COG3938	Belongs to the proline racemase family
L6178_13730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6178_13770	COG0586	Pfam SNARE associated Golgi protein
L6178_13785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6178_13790	COG0519	Catalyzes the synthesis of GMP from XMP
L6178_13795	COG4166	transmembrane transport
L6178_13805	COG4948	Mandelate Racemase Muconate Lactonizing
L6178_13850	COG2936	dipeptidyl-peptidase activity
L6178_13855	COG5002	protein histidine kinase activity
L6178_13905	COG1307	EDD domain protein, DegV family
L6178_13925	COG2814	Major facilitator Superfamily
L6178_13935	COG1664	Polymer-forming cytoskeletal
L6178_13940	COG0789	Transcriptional regulator
L6178_13945	COG4533	DNA binding
L6178_13950	COG2814	Major facilitator Superfamily
L6178_13950	COG0477	Major facilitator Superfamily
L6178_13970	COG2261	transglycosylase associated protein
L6178_13985	COG2226	methyltransferase
L6178_14020	COG0436	Aminotransferase
L6178_14025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6178_14030	COG5146	pantothenate kinase activity
L6178_14095	COG0628	permease
L6178_14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_14115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_14120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_14125	COG1116	anion transmembrane transporter activity
L6178_14145	COG2816	NAD+ diphosphatase activity
L6178_14165	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6178_14190	COG0697	spore germination
L6178_14195	COG2318	DinB family
L6178_14215	COG4912	Dna alkylation repair
L6178_14235	COG0861	Integral membrane protein TerC family
L6178_14240	COG1368	sulfuric ester hydrolase activity
L6178_14245	COG0488	(ABC) transporter
L6178_14260	COG1309	transcriptional regulator
L6178_14275	COG0287	Prephenate dehydrogenase
L6178_14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6178_14285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6178_14290	COG1605	Chorismate mutase
L6178_14290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6178_14325	COG3584	3D domain protein
L6178_14325	COG1388	LysM domain
L6178_14335	COG1595	DNA-templated transcription, initiation
L6178_14360	COG1879	ABC-type sugar transport system periplasmic component
L6178_14370	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6178_14380	COG2390	Transcriptional regulator
L6178_14415	COG2329	Antibiotic biosynthesis monooxygenase
L6178_14435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_14445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L6178_14450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_14455	COG4187	Peptidase family M20/M25/M40
L6178_14460	COG1414	Transcriptional regulator
L6178_14465	COG0833	amino acid
L6178_14470	COG1690	Belongs to the RtcB family
L6178_14480	COG1785	Belongs to the alkaline phosphatase family
L6178_14490	COG3655	Transcriptional regulator
L6178_14505	COG4377	Putative membrane peptidase family (DUF2324)
L6178_14515	COG3279	Response regulator of the LytR AlgR family
L6178_14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_14530	COG0346	lactoylglutathione lyase activity
L6178_14550	COG0714	Associated with various cellular activities
L6178_14575	COG0463	Glycosyl transferase, family 2
L6178_14595	COG0463	Glycosyl transferase, family 2
L6178_14605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6178_14610	COG0753	catalase activity
L6178_14620	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6178_14645	COG0714	Associated with various cellular activities
L6178_14655	COG0778	Nitroreductase
L6178_14660	COG1846	Transcriptional regulator
L6178_14695	COG1725	Transcriptional regulator
L6178_14705	COG0577	efflux transmembrane transporter activity
L6178_14705	COG1136	(ABC) transporter
L6178_14730	COG2207	Transcriptional regulator
L6178_14735	COG0456	acetyltransferase
L6178_14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_14775	COG0642	Histidine kinase
L6178_14780	COG0745	RESPONSE REGULATOR receiver
L6178_14785	COG0596	Alpha beta hydrolase
L6178_14815	COG0730	response to heat
L6178_14825	COG0833	amino acid
L6178_14835	COG4335	DNA alkylation repair
L6178_14875	COG0768	penicillin binding
L6178_14885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6178_14920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6178_14925	COG1414	Transcriptional regulator
L6178_14940	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6178_14945	COG0640	Transcriptional regulator
L6178_14955	COG1960	acyl-CoA dehydrogenase activity
L6178_14975	COG3314	Sporulation integral membrane protein YlbJ
L6178_14990	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L6178_15005	COG3848	Pyruvate phosphate dikinase
L6178_15005	COG0574	Belongs to the PEP-utilizing enzyme family
L6178_15010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_15025	COG5577	PFAM Coat F domain
L6178_15030	COG3403	YqcI/YcgG family
L6178_15035	COG1280	lysine exporter protein (LysE YggA)
L6178_15070	COG1063	alcohol dehydrogenase
L6178_15085	COG1027	Aspartate ammonia-lyase
L6178_15090	COG0252	asparaginase activity
L6178_15095	COG1396	sequence-specific DNA binding
L6178_15105	COG0322	excinuclease ABC activity
L6178_15110	COG0531	amino acid
L6178_15115	COG1114	Component of the transport system for branched-chain amino acids
L6178_15120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_15130	COG0281	malic enzyme
L6178_15145	COG0531	amino acid
L6178_15155	COG0784	Response regulator, receiver
L6178_15165	COG2066	Belongs to the glutaminase family
L6178_15200	COG0737	Belongs to the 5'-nucleotidase family
L6178_15205	COG0753	catalase activity
L6178_15210	COG2267	carboxylic ester hydrolase activity
L6178_15215	COG1335	isochorismatase
L6178_15235	COG0583	DNA-binding transcription factor activity
L6178_15285	COG0415	Belongs to the DNA photolyase family
L6178_15290	COG0288	reversible hydration of carbon dioxide
L6178_15300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6178_15305	COG5609	conserved protein (DUF2294)
L6178_15320	COG1575	Belongs to the MenA family. Type 1 subfamily
L6178_15325	COG2267	carboxylic ester hydrolase activity
L6178_15330	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6178_15335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6178_15340	COG1121	(ABC) transporter
L6178_15370	COG0798	PFAM Bile acid sodium symporter
L6178_15375	COG0346	lactoylglutathione lyase activity
L6178_15380	COG0640	Transcriptional regulator
L6178_15395	COG0443	Heat shock 70 kDa protein
L6178_15410	COG1522	sequence-specific DNA binding
L6178_15425	COG0346	lactoylglutathione lyase activity
L6178_15500	COG2814	Major facilitator Superfamily
L6178_15525	COG0745	RESPONSE REGULATOR receiver
L6178_15530	COG5002	protein histidine kinase activity
L6178_15530	COG3850	Histidine kinase
L6178_15555	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6178_15575	COG1476	TRANSCRIPTIONal
L6178_15590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_15595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6178_15605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_15610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6178_15625	COG1136	(ABC) transporter
L6178_15630	COG0577	efflux transmembrane transporter activity
L6178_15645	COG5002	protein histidine kinase activity
L6178_15645	COG3850	Histidine kinase
L6178_15655	COG2364	Membrane
L6178_15660	COG1846	Transcriptional regulator
L6178_15670	COG2808	Putative FMN-binding domain
L6178_15675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_15680	COG2271	Major facilitator Superfamily
L6178_15685	COG1556	Lactate utilization protein
L6178_15690	COG1139	Iron-sulfur cluster binding protein
L6178_15700	COG0583	DNA-binding transcription factor activity
L6178_15710	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_15735	COG0738	Major facilitator superfamily
L6178_15740	COG0673	inositol 2-dehydrogenase activity
L6178_15745	COG0561	phosphatase activity
L6178_15755	COG1609	Transcriptional regulator
L6178_15760	COG0457	Tetratricopeptide repeat
L6178_15780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6178_15810	COG0534	Mate efflux family protein
L6178_15830	COG2814	Major facilitator Superfamily
L6178_15835	COG1309	transcriptional regulator
L6178_15850	COG0814	amino acid
L6178_15855	COG1760	l-serine dehydratase
L6178_15860	COG1760	l-serine dehydratase
L6178_15870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6178_15875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6178_15885	COG1335	isochorismatase
L6178_15890	COG1522	sequence-specific DNA binding
L6178_15895	COG0531	amino acid
L6178_15915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6178_15935	COG1595	DNA-templated transcription, initiation
L6178_15950	COG0662	Cupin 2, conserved barrel domain protein
L6178_15955	COG2207	Transcriptional regulator
L6178_15955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_16005	COG0477	Major facilitator Superfamily
L6178_16015	COG1846	Transcriptional regulator
L6178_16020	COG2814	Major facilitator Superfamily
L6178_16030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_16035	COG1131	(ABC) transporter
L6178_16055	COG2076	Multidrug Resistance protein
L6178_16060	COG1309	transcriptional regulator
L6178_16070	COG2031	fatty acid transporter
L6178_16080	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_16110	COG1122	ATPase activity
L6178_16115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6178_16130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6178_16135	COG1288	antiporter activity
L6178_16140	COG2356	endonuclease I
L6178_16155	COG3620	sequence-specific DNA binding
L6178_16160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_16165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6178_16170	COG0124	histidyl-tRNA synthetase
L6178_16185	COG1733	regulation of RNA biosynthetic process
L6178_16190	COG0778	Nitroreductase
L6178_16210	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_16220	COG1131	(ABC) transporter
L6178_16245	COG1011	Hydrolase
L6178_16255	COG2365	Tyrosine phosphatase family
L6178_16280	COG0346	lactoylglutathione lyase activity
L6178_16285	COG1940	carbohydrate kinase activity
L6178_16290	COG0738	Major facilitator superfamily
L6178_16295	COG0110	maltose O-acetyltransferase activity
L6178_16305	COG0577	efflux transmembrane transporter activity
L6178_16305	COG1136	(ABC) transporter
L6178_16320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6178_16325	COG0628	permease
L6178_16345	COG2226	methyltransferase
L6178_16355	COG0477	Major facilitator Superfamily
L6178_16385	COG1253	flavin adenine dinucleotide binding
L6178_16390	COG0789	Transcriptional regulator
L6178_16395	COG0697	spore germination
L6178_16400	COG1357	PFAM Pentapeptide repeats (8 copies)
L6178_16405	COG3813	Protein conserved in bacteria
L6178_16410	COG2706	6-phosphogluconolactonase activity
L6178_16415	COG1070	Carbohydrate kinase
L6178_16425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6178_16430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6178_16440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6178_16445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6178_16450	COG0604	alcohol dehydrogenase
L6178_16455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6178_16465	COG0604	alcohol dehydrogenase
L6178_16465	COG3321	synthase
L6178_16470	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_16495	COG0656	L-ascorbic acid biosynthetic process
L6178_16500	COG2814	Major facilitator Superfamily
L6178_16515	COG0346	lactoylglutathione lyase activity
L6178_16520	COG0814	amino acid
L6178_16545	COG1393	Belongs to the ArsC family
L6178_16550	COG1733	regulation of RNA biosynthetic process
L6178_16555	COG2188	Transcriptional regulator
L6178_16565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6178_16570	COG1733	regulation of RNA biosynthetic process
L6178_16575	COG1733	regulation of RNA biosynthetic process
L6178_16590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_16610	COG0384	phenazine biosynthesis protein PhzF
L6178_16620	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_16630	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_16640	COG1733	regulation of RNA biosynthetic process
L6178_16670	COG1191	sigma factor activity
L6178_16685	COG1309	transcriptional regulator
L6178_16705	COG3152	Membrane
L6178_16730	COG1151	hydroxylamine reductase activity
L6178_16740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_16745	COG3757	hydrolase, family 25
L6178_16745	COG3409	Peptidoglycan-binding domain 1 protein
L6178_16780	COG2072	flavoprotein involved in K transport
L6178_16820	COG1113	amino acid transport
L6178_16825	COG2814	Major facilitator Superfamily
L6178_16855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_16860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_16885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_16890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_16895	COG3739	integral membrane protein
L6178_16900	COG0384	phenazine biosynthesis protein PhzF
L6178_16930	COG0583	DNA-binding transcription factor activity
L6178_16950	COG1193	negative regulation of DNA recombination
L6178_16970	COG1164	Oligoendopeptidase f
L6178_16975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6178_17005	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_17030	COG0640	Transcriptional regulator
L6178_17035	COG0604	alcohol dehydrogenase
L6178_17055	COG2808	Putative FMN-binding domain
L6178_17060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_17070	COG0385	Bile acid
L6178_17075	COG0277	FAD linked oxidase domain protein
L6178_17105	COG1216	Glycosyl transferase, family 2
L6178_17110	COG1024	Enoyl-CoA hydratase
L6178_17120	COG1285	pathogenesis
L6178_17135	COG2514	catechol 2,3-dioxygenase activity
L6178_17140	COG2720	vancomycin resistance protein
L6178_17180	COG0716	FMN binding
L6178_17210	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_17220	COG0165	Argininosuccinate lyase
L6178_17235	COG4145	pantothenate transmembrane transporter activity
L6178_17245	COG1012	belongs to the aldehyde dehydrogenase family
L6178_17250	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_17260	COG1657	PFAM Prenyltransferase squalene oxidase
L6178_17265	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6178_17270	COG2962	Rard protein
L6178_17275	COG3326	Membrane
L6178_17290	COG0489	protein tyrosine kinase activity
L6178_17300	COG0314	molybdopterin synthase activity
L6178_17305	COG0303	'Molybdopterin
L6178_17310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_17315	COG2116	formate transmembrane transporter activity
L6178_17325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6178_17330	COG5609	conserved protein (DUF2294)
L6178_17335	COG2427	Protein of unknown function (DUF1641)
L6178_17340	COG3383	formate dehydrogenase (NAD+) activity
L6178_17350	COG0697	spore germination
L6178_17390	COG2226	methyltransferase
L6178_17395	COG4166	transmembrane transport
L6178_17400	COG4166	transmembrane transport
L6178_17405	COG4166	transmembrane transport
L6178_17415	COG1316	TRANSCRIPTIONal
L6178_17425	COG1595	DNA-templated transcription, initiation
L6178_17445	COG1131	(ABC) transporter
L6178_17455	COG0673	inositol 2-dehydrogenase activity
L6178_17460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6178_17465	COG0187	DNA topoisomerase II activity
L6178_17470	COG1832	CoA-binding protein
L6178_17475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_17480	COG0745	RESPONSE REGULATOR receiver
L6178_17495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6178_17500	COG4841	protein insertion into membrane
L6178_17505	COG0824	Thioesterase
L6178_17535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_17545	COG2274	protein secretion by the type I secretion system
L6178_17550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6178_17590	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_17605	COG0183	Belongs to the thiolase family
L6178_17610	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_17615	COG1268	BioY protein
L6178_17620	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_17670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_17680	COG5002	protein histidine kinase activity
L6178_17685	COG0400	carboxylic ester hydrolase activity
L6178_17690	COG0346	lactoylglutathione lyase activity
L6178_17695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6178_17700	COG0069	glutamate synthase activity
L6178_17705	COG1902	pentaerythritol trinitrate reductase activity
L6178_17710	COG1329	Transcriptional regulator
L6178_17715	COG0010	Belongs to the arginase family
L6178_17740	COG2226	methyltransferase
L6178_17775	COG4846	Membrane protein involved in cytochrome C biogenesis
L6178_17780	COG0785	Cytochrome C biogenesis protein
L6178_17790	COG0583	DNA-binding transcription factor activity
L6178_17795	COG1380	Effector of murein hydrolase LrgA
L6178_17800	COG1346	cytolysis
L6178_17825	COG3409	Peptidoglycan-binding domain 1 protein
L6178_17825	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6178_17840	COG1132	(ABC) transporter
L6178_17845	COG1132	(ABC) transporter
L6178_17875	COG3639	organic phosphonate transmembrane transporter activity
L6178_17880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6178_17900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6178_17920	COG1695	Transcriptional regulator
L6178_17965	COG1388	LysM domain
L6178_17965	COG3409	Peptidoglycan-binding domain 1 protein
L6178_17965	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6178_17970	COG4824	toxin secretion phage lysis holin
L6178_18125	COG1595	DNA-templated transcription, initiation
L6178_18170	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L6178_18255	COG1396	sequence-specific DNA binding
L6178_18280	COG0174	glutamine synthetase
L6178_18285	COG0789	Transcriptional regulator
L6178_18290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6178_18300	COG2860	membrane
L6178_18305	COG0464	growth
L6178_18335	COG3584	3D domain protein
L6178_18335	COG1388	LysM domain
L6178_18340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6178_18340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6178_18340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_18345	COG1105	Belongs to the carbohydrate kinase PfkB family
L6178_18350	COG1349	DNA-binding transcription factor activity
L6178_18360	COG2322	membrane
L6178_18370	COG1113	amino acid transport
L6178_18385	COG1408	metallophosphoesterase
L6178_18390	COG2116	formate transmembrane transporter activity
L6178_18400	COG2217	Heavy metal translocating P-type atpase
L6178_18405	COG2608	mercury ion transmembrane transporter activity
L6178_18410	COG1937	Protein conserved in bacteria
L6178_18420	COG2819	hydrolase of the alpha beta superfamily
L6178_18425	COG1120	ATPase activity
L6178_18430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_18435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_18445	COG0708	Exodeoxyribonuclease III
L6178_18450	COG2169	Transcriptional regulator
L6178_18455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6178_18460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6178_18470	COG2364	Membrane
L6178_18485	COG2267	carboxylic ester hydrolase activity
L6178_18490	COG0346	lactoylglutathione lyase activity
L6178_18495	COG5001	Diguanylate cyclase
L6178_18495	COG3300	MHYT domain
L6178_18510	COG1346	cytolysis
L6178_18515	COG1380	Effector of murein hydrolase LrgA
L6178_18520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6178_18525	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_18525	COG0596	Alpha beta hydrolase
L6178_18530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6178_18550	COG1404	Belongs to the peptidase S8 family
L6178_18555	COG3773	Cell wall hydrolase
L6178_18560	COG0562	UDP-galactopyranose mutase
L6178_18565	COG1368	sulfuric ester hydrolase activity
L6178_18570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6178_18580	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6178_18605	COG1131	(ABC) transporter
L6178_18625	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6178_18630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6178_18635	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6178_18640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6178_18640	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6178_18650	COG2359	stage V sporulation protein S
L6178_18655	COG1692	metallophosphoesterase
L6178_18680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6178_18685	COG1426	Protein conserved in bacteria
L6178_18700	COG0300	oxidoreductase activity
L6178_18705	COG0612	Peptidase, M16
L6178_18710	COG0612	Peptidase, M16
L6178_18725	COG3845	ABC transporter
L6178_18730	COG1744	ABC transporter substrate-binding protein PnrA-like
L6178_18735	COG2188	Transcriptional regulator
L6178_18740	COG1674	ftsk spoiiie
L6178_18750	COG0740	serine-type endopeptidase activity
L6178_18765	COG0527	aspartate kinase activity
L6178_18770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6178_18775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6178_18780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6178_18785	COG1873	PFAM PRC-barrel domain
L6178_18790	COG0612	Peptidase, M16
L6178_18795	COG0726	polysaccharide deacetylase
L6178_18810	COG0196	riboflavin kinase activity
L6178_18815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6178_18825	COG1550	Protein conserved in bacteria
L6178_18835	COG1358	cellular component organization or biogenesis
L6178_18840	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6178_18845	COG0195	Participates in both transcription termination and antitermination
L6178_18865	COG0750	zinc metalloprotease
L6178_18875	COG4589	Belongs to the CDS family
L6178_18880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6178_18890	COG0528	UMP kinase activity
L6178_18920	COG4974	Belongs to the 'phage' integrase family
L6178_18930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6178_18940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6178_18980	COG1837	Belongs to the UPF0109 family
L6178_18990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6178_19000	COG0552	protein localization to endoplasmic reticulum
L6178_19005	COG1196	nuclear chromosome segregation
L6178_19015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6178_19020	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_19025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6178_19040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6178_19045	COG1461	Dihydroxyacetone kinase
L6178_19050	COG1302	Protein conserved in bacteria
L6178_19065	COG1564	THIamine pyrophosphokinase
L6178_19070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6178_19075	COG1162	GTPase activity
L6178_19080	COG0515	serine threonine protein kinase
L6178_19080	COG2815	serine threonine protein kinase
L6178_19085	COG0631	protein serine/threonine phosphatase activity
L6178_19095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6178_19095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6178_19105	COG0242	peptide deformylase activity
L6178_19110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6178_19115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6178_19135	COG1561	YicC-like family, N-terminal region
L6178_19140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6178_19150	COG0006	proline dipeptidase activity
L6178_19165	COG3069	C4-dicarboxylate transmembrane transporter activity
L6178_19230	COG0564	pseudouridine synthase activity
L6178_19250	COG3599	regulation of cell shape
L6178_19255	COG2302	S4 RNA-binding domain
L6178_19260	COG0762	integral membrane protein
L6178_19270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6178_19275	COG1496	oxidoreductase activity
L6178_19280	COG1873	PFAM PRC-barrel domain
L6178_19285	COG1191	sigma factor activity
L6178_19290	COG1191	sigma factor activity
L6178_19300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6178_19305	COG0849	cell division
L6178_19310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6178_19315	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6178_19325	COG0772	Belongs to the SEDS family
L6178_19340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6178_19345	COG0768	penicillin binding
L6178_19350	COG0768	penicillin binding
L6178_19355	COG4839	cell division protein FtsL
L6178_19370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6178_19385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6178_19390	COG1399	metal-binding, possibly nucleic acid-binding protein
L6178_19440	COG4824	toxin secretion phage lysis holin
L6178_19540	COG1802	Transcriptional regulator
L6178_19540	COG4626	Terminase
L6178_19565	COG0582	viral genome integration into host DNA
L6178_19630	COG0756	dUTP diphosphatase activity
L6178_19645	COG1191	sigma factor activity
L6178_19670	COG1484	DNA-dependent DNA replication
L6178_19700	COG1396	sequence-specific DNA binding
L6178_19715	COG1396	sequence-specific DNA binding
L6178_19730	COG0582	viral genome integration into host DNA
L6178_19740	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6178_19745	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6178_19750	COG3314	Sporulation integral membrane protein YlbJ
L6178_19760	COG0742	ribosomal rna small subunit methyltransferase
L6178_19775	COG3679	Belongs to the UPF0342 family
L6178_19780	COG0406	alpha-ribazole phosphatase activity
L6178_19795	COG2340	Cysteine-rich secretory protein family
L6178_19810	COG3336	cytochrome c oxidase
L6178_19845	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6178_19850	COG0772	Belongs to the SEDS family
L6178_19860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6178_19865	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6178_19875	COG4896	Protein conserved in bacteria
L6178_19890	COG1217	gtp-binding protein TYPA
L6178_19900	COG0483	inositol monophosphate 1-phosphatase activity
L6178_19920	COG1982	Orn Lys Arg decarboxylase major
L6178_19965	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_19970	COG0022	dehydrogenase e1 component
L6178_19975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_19985	COG0242	peptide deformylase activity
L6178_19990	COG0561	phosphatase activity
L6178_20000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6178_20005	COG0569	domain protein
L6178_20025	COG0583	DNA-binding transcription factor activity
L6178_20030	COG0517	IMP dehydrogenase activity
L6178_20040	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6178_20050	COG4703	Protein of unknown function (DUF1797)
L6178_20065	COG2200	EAL domain
L6178_20070	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_20075	COG1408	metallophosphoesterase
L6178_20085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6178_20120	COG2814	Major facilitator Superfamily
L6178_20140	COG3209	COG3209 Rhs family protein
L6178_20150	COG2205	protein histidine kinase activity
L6178_20160	COG0436	Aminotransferase
L6178_20165	COG1609	Transcriptional regulator
L6178_20170	COG3833	ABC-type maltose transport systems, permease component
L6178_20175	COG1175	transmembrane transport
L6178_20180	COG2182	Extracellular solute-binding protein
L6178_20190	COG0366	Alpha amylase catalytic
L6178_20195	COG3842	ATPase activity
L6178_20235	COG0183	Belongs to the thiolase family
L6178_20270	COG1695	Transcriptional regulator
L6178_20275	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_20285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L6178_20295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6178_20300	COG0436	Aminotransferase
L6178_20320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L6178_20340	COG2199	diguanylate cyclase activity
L6178_20345	COG0778	Nitroreductase
L6178_20370	COG1263	PTS System
L6178_20370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6178_20370	COG2190	(PTS) system
L6178_20375	COG3711	transcriptional antiterminator
L6178_20385	COG2188	Transcriptional regulator
L6178_20395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6178_20420	COG1547	Domain of unknown function (DUF309)
L6178_20425	COG0456	acetyltransferase
L6178_20435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6178_20440	COG4086	secreted protein
L6178_20445	COG0561	phosphatase activity
L6178_20450	COG0697	spore germination
L6178_20465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_20490	COG0733	neurotransmitter:sodium symporter activity
L6178_20510	COG1686	Belongs to the peptidase S11 family
L6178_20515	COG1725	Transcriptional regulator
L6178_20520	COG1131	(ABC) transporter
L6178_20535	COG1846	Transcriptional regulator
L6178_20550	COG0598	Magnesium transport protein CorA
L6178_20575	COG4974	Belongs to the 'phage' integrase family
L6178_20585	COG0735	belongs to the Fur family
L6178_20590	COG1300	Membrane
L6178_20610	COG0667	Aldo Keto reductase
L6178_20615	COG0656	L-ascorbic acid biosynthetic process
L6178_20620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6178_20620	COG0456	acetyltransferase
L6178_20630	COG4085	toxin activity
L6178_20630	COG0737	Belongs to the 5'-nucleotidase family
L6178_20630	COG1525	nuclease
L6178_20640	COG0596	Alpha beta hydrolase
L6178_20645	COG2056	Na+-H+ antiporter family
L6178_20650	COG1609	Transcriptional regulator
L6178_20655	COG0456	acetyltransferase
L6178_20660	COG1073	alpha beta
L6178_20675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6178_20675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6178_20680	COG0307	riboflavin synthase, alpha
L6178_20705	COG4106	trans-aconitate 2-methyltransferase activity
L6178_20710	COG1073	alpha beta
L6178_20710	COG2226	methyltransferase
L6178_20725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6178_20735	COG1757	Na H antiporter
L6178_20740	COG0737	Belongs to the 5'-nucleotidase family
L6178_20750	COG1522	sequence-specific DNA binding
L6178_20770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6178_20780	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6178_20795	COG0300	oxidoreductase activity
L6178_20805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_20810	COG1760	l-serine dehydratase
L6178_20815	COG1760	l-serine dehydratase
L6178_20835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6178_20845	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6178_20850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_20865	COG1376	ErfK ybiS ycfS ynhG family protein
L6178_20870	COG4129	membrane
L6178_20875	COG1126	abc transporter atp-binding protein
L6178_20880	COG0765	amino acid transport
L6178_20885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6178_20900	COG2816	NAD+ diphosphatase activity
L6178_20905	COG0772	Belongs to the SEDS family
L6178_20910	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6178_20915	COG0022	dehydrogenase e1 component
L6178_20920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6178_20925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6178_20940	COG0280	phosphate acetyltransferase
L6178_20945	COG3290	protein histidine kinase activity
L6178_20945	COG3829	transcription factor binding
L6178_20955	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_20960	COG3093	addiction module antidote protein HigA
L6178_20970	COG0745	RESPONSE REGULATOR receiver
L6178_20975	COG0750	zinc metalloprotease
L6178_20980	COG0497	DNA recombination
L6178_20990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6178_21000	COG0142	geranyltranstransferase activity
L6178_21025	COG1302	Protein conserved in bacteria
L6178_21030	COG0439	Biotin carboxylase
L6178_21035	COG0511	ligase activity, forming carbon-carbon bonds
L6178_21080	COG3854	ATPases associated with a variety of cellular activities
L6178_21105	COG0006	proline dipeptidase activity
L6178_21120	COG3872	metal-dependent enzyme
L6178_21130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6178_21150	COG0095	Lipoate-protein ligase
L6178_21155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_21160	COG1609	Transcriptional regulator
L6178_21170	COG2076	Multidrug Resistance protein
L6178_21175	COG2076	Multidrug Resistance protein
L6178_21210	COG1131	(ABC) transporter
L6178_21215	COG1725	Transcriptional regulator
L6178_21245	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_21300	COG4970	Tfp pilus assembly protein FimT
L6178_21310	COG1459	type II secretion system
L6178_21315	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6178_21365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6178_21370	COG0646	methionine synthase
L6178_21370	COG1410	methionine synthase
L6178_21375	COG0646	methionine synthase
L6178_21375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6178_21380	COG0626	cystathionine gamma-synthase activity
L6178_21385	COG0626	cystathionine gamma-synthase activity
L6178_21405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_21415	COG1940	carbohydrate kinase activity
L6178_21420	COG4483	Protein conserved in bacteria
L6178_21425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6178_21430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6178_21435	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6178_21440	COG0704	Plays a role in the regulation of phosphate uptake
L6178_21450	COG0581	inorganic phosphate transmembrane transporter activity
L6178_21455	COG0573	inorganic phosphate transmembrane transporter activity
L6178_21460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6178_21465	COG0768	penicillin binding
L6178_21470	COG0477	Major facilitator Superfamily
L6178_21475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_21500	COG0735	belongs to the Fur family
L6178_21505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6178_21510	COG1121	(ABC) transporter
L6178_21515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_21545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6178_21550	COG2384	SAM-dependent methyltransferase
L6178_21555	COG2010	Cytochrome c
L6178_21560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6178_21565	COG0358	DNA primase activity
L6178_21575	COG0517	IMP dehydrogenase activity
L6178_21590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6178_21595	COG0295	cytidine deaminase activity
L6178_21600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6178_21610	COG1480	7TM receptor with intracellular HD hydrolase
L6178_21615	COG1702	phosphate starvation-inducible protein PhoH
L6178_21630	COG1610	YqeY-like protein
L6178_21635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6178_21640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6178_21645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6178_21675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6178_21680	COG1733	regulation of RNA biosynthetic process
L6178_21705	COG1466	dna polymerase III delta subunit
L6178_21715	COG0658	competence protein
L6178_21715	COG2333	competence protein COMEC
L6178_21720	COG2131	deaminase
L6178_21725	COG1596	polysaccharide export
L6178_21725	COG1555	photosystem II stabilization
L6178_21730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6178_21735	COG2226	methyltransferase
L6178_21740	COG0799	negative regulation of ribosome biogenesis
L6178_21745	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6178_21755	COG1534	Rna-binding protein
L6178_21765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6178_21770	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6178_21795	COG1595	DNA-templated transcription, initiation
L6178_21805	COG0778	Nitroreductase
L6178_21810	COG2357	RelA SpoT domain protein
L6178_21820	COG1785	Belongs to the alkaline phosphatase family
L6178_21830	COG2267	carboxylic ester hydrolase activity
L6178_21865	COG1404	Belongs to the peptidase S8 family
L6178_21870	COG3186	Phenylalanine-4-hydroxylase
L6178_21885	COG2259	Doxx family
L6178_21925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_21935	COG1012	belongs to the aldehyde dehydrogenase family
L6178_21935	COG1454	alcohol dehydrogenase
L6178_21940	COG0626	cystathionine gamma-synthase activity
L6178_21945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6178_21970	COG0768	penicillin binding
L6178_21985	COG0826	peptidase U32
L6178_21990	COG0826	peptidase U32
L6178_21995	COG4122	O-methyltransferase activity
L6178_22000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6178_22020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6178_22030	COG0628	permease
L6178_22050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6178_22060	COG0482	sulfurtransferase activity
L6178_22065	COG1104	cysteine desulfurase activity
L6178_22070	COG1959	2 iron, 2 sulfur cluster binding
L6178_22075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6178_22085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6178_22110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6178_22120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6178_22120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6178_22125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6178_22130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6178_22130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6178_22140	COG2244	polysaccharide biosynthetic process
L6178_22145	COG2323	membrane
L6178_22155	COG1862	Preprotein translocase
L6178_22185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6178_22195	COG0697	spore germination
L6178_22200	COG0697	spore germination
L6178_22205	COG0640	Transcriptional regulator
L6178_22230	COG0157	Belongs to the NadC ModD family
L6178_22235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6178_22240	COG1104	cysteine desulfurase activity
L6178_22245	COG1827	regulation of RNA biosynthetic process
L6178_22250	COG2258	MOSC domain
L6178_22255	COG0077	Prephenate dehydratase
L6178_22260	COG0577	efflux transmembrane transporter activity
L6178_22265	COG0577	efflux transmembrane transporter activity
L6178_22270	COG1136	(ABC) transporter
L6178_22280	COG0745	RESPONSE REGULATOR receiver
L6178_22285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6178_22290	COG3290	protein histidine kinase activity
L6178_22300	COG2868	ribosomal protein
L6178_22310	COG1530	ribonuclease E activity
L6178_22315	COG1994	Peptidase M50
L6178_22320	COG0739	heme binding
L6178_22325	COG2894	cell division
L6178_22345	COG1077	Cell shape determining protein MreB Mrl
L6178_22365	COG0285	dihydrofolate synthase activity
L6178_22370	COG0525	valine-tRNA ligase activity
L6178_22380	COG1388	LysM domain
L6178_22390	COG0113	porphobilinogen synthase activity
L6178_22395	COG1587	Uroporphyrinogen-III synthase
L6178_22405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6178_22415	COG1846	Transcriptional regulator
L6178_22420	COG1764	response to oxidative stress
L6178_22435	COG1067	ATP-dependent peptidase activity
L6178_22435	COG0470	DNA polymerase III
L6178_22480	COG0622	Phosphoesterase
L6178_22495	COG5401	PFAM Sporulation and spore germination
L6178_22515	COG1309	transcriptional regulator
L6178_22530	COG2197	response regulator
L6178_22535	COG2233	PERMEase
L6178_22545	COG0402	S-adenosylhomocysteine deaminase activity
L6178_22550	COG0402	S-adenosylhomocysteine deaminase activity
L6178_22560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6178_22570	COG0444	Belongs to the ABC transporter superfamily
L6178_22575	COG4608	Belongs to the ABC transporter superfamily
L6178_22580	COG3275	phosphorelay sensor kinase activity
L6178_22585	COG3279	Response regulator of the LytR AlgR family
L6178_22600	COG1983	PspC domain protein
L6178_22605	COG1396	sequence-specific DNA binding
L6178_22610	COG0697	spore germination
L6178_22620	COG1959	2 iron, 2 sulfur cluster binding
L6178_22625	COG1668	transmembrane transport
L6178_22630	COG4152	abc transporter atp-binding protein
L6178_22635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6178_22645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6178_22650	COG1876	peptidase activity
L6178_22655	COG0824	Thioesterase
L6178_22660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6178_22665	COG1053	succinate dehydrogenase
L6178_22670	COG2009	succinate dehydrogenase
L6178_22675	COG1719	4-vinyl reductase, 4VR
L6178_22685	COG3118	belongs to the thioredoxin family
L6178_22690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6178_22695	COG2086	electron transfer activity
L6178_22700	COG1024	Enoyl-CoA hydratase
L6178_22710	COG0318	PFAM AMP-dependent synthetase and ligase
L6178_22730	COG2318	DinB family
L6178_22760	COG1131	(ABC) transporter
L6178_22765	COG2205	protein histidine kinase activity
L6178_22770	COG0745	RESPONSE REGULATOR receiver
L6178_22780	COG4895	conserved protein (DUF2196)
L6178_22785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6178_22800	COG4509	Sortase family
L6178_22805	COG1120	ATPase activity
L6178_22820	COG5386	Cell surface protein
L6178_22830	COG5386	Cell surface protein
L6178_22835	COG1114	Component of the transport system for branched-chain amino acids
L6178_22840	COG1187	pseudouridine synthase activity
L6178_22850	COG1796	DNA polymerase
L6178_22850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6178_22855	COG1286	toxin biosynthetic process
L6178_22900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6178_22910	COG1418	mRNA catabolic process
L6178_22935	COG2814	Major facilitator Superfamily
L6178_22940	COG1566	PFAM secretion protein HlyD family protein
L6178_22945	COG1309	transcriptional regulator
L6178_22950	COG1363	Peptidase, m42
L6178_22975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6178_22985	COG1484	DNA-dependent DNA replication
L6178_22990	COG3611	Membrane attachment protein
L6178_23000	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6178_23005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6178_23010	COG0237	dephospho-CoA kinase activity
L6178_23015	COG1971	Probably functions as a manganese efflux pump
L6178_23025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_23025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6178_23030	COG5002	protein histidine kinase activity
L6178_23035	COG0745	RESPONSE REGULATOR receiver
L6178_23055	COG0538	isocitrate dehydrogenase activity
L6178_23060	COG0372	Belongs to the citrate synthase family
L6178_23070	COG0628	permease
L6178_23075	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6178_23100	COG1725	Transcriptional regulator
L6178_23105	COG0281	malic enzyme
L6178_23110	COG0587	DNA-directed DNA polymerase activity
L6178_23125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6178_23145	COG4109	DRTGG domain
L6178_23160	COG0006	proline dipeptidase activity
L6178_23200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_23205	COG0662	Cupin 2, conserved barrel domain protein
L6178_23215	COG1476	TRANSCRIPTIONal
L6178_23230	COG1028	Short-chain dehydrogenase reductase Sdr
L6178_23235	COG0589	response to stress
L6178_23275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_23295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6178_23300	COG0827	DNA restriction-modification system
L6178_23305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6178_23310	COG3874	Sporulation protein YtfJ
L6178_23325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6178_23335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_23350	COG1104	cysteine desulfurase activity
L6178_23360	COG0583	DNA-binding transcription factor activity
L6178_23365	COG0697	spore germination
L6178_23375	COG1956	GAF domain-containing protein
L6178_23380	COG0626	cystathionine gamma-synthase activity
L6178_23410	COG1595	DNA-templated transcription, initiation
L6178_23420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6178_23425	COG0454	-acetyltransferase
L6178_23430	COG0517	IMP dehydrogenase activity
L6178_23435	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6178_23445	COG0745	RESPONSE REGULATOR receiver
L6178_23455	COG0666	response to abiotic stimulus
L6178_23490	COG1609	Transcriptional regulator
L6178_23495	COG4851	CamS sex pheromone cAM373 precursor
L6178_23500	COG3118	belongs to the thioredoxin family
L6178_23510	COG2309	aminopeptidase activity
L6178_23530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_23545	COG1674	ftsk spoiiie
L6178_23555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6178_23560	COG4848	Belongs to the UPF0354 family
L6178_23565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_23570	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6178_23575	COG1363	Peptidase, m42
L6178_23585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_23600	COG0510	thiamine kinase activity
L6178_23605	COG1523	belongs to the glycosyl hydrolase 13 family
L6178_23620	COG1349	DNA-binding transcription factor activity
L6178_23625	COG1187	pseudouridine synthase activity
L6178_23630	COG2244	polysaccharide biosynthetic process
L6178_23635	COG2081	HI0933 family
L6178_23640	COG2814	Major facilitator Superfamily
L6178_23650	COG3832	glyoxalase III activity
L6178_23670	COG1329	Transcriptional regulator
L6178_23680	COG4975	Glucose uptake
L6178_23695	COG0314	molybdopterin synthase activity
L6178_23700	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6178_23705	COG0303	'Molybdopterin
L6178_23715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6178_23740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6178_23750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6178_23795	COG2814	Major facilitator Superfamily
L6178_23800	COG0475	glutathione-regulated potassium exporter activity
L6178_23805	COG0490	domain, Protein
L6178_23810	COG0582	viral genome integration into host DNA
L6178_23820	COG1136	(ABC) transporter
L6178_23840	COG1242	4 iron, 4 sulfur cluster binding
L6178_23845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6178_23850	COG1131	(ABC) transporter
L6178_23860	COG1794	racemase activity, acting on amino acids and derivatives
L6178_23880	COG2267	carboxylic ester hydrolase activity
L6178_23885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6178_23890	COG0671	phosphoesterase, PA-phosphatase related
L6178_23895	COG0438	transferase activity, transferring glycosyl groups
L6178_23905	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6178_23960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6178_23965	COG5002	protein histidine kinase activity
L6178_23970	COG4191	Histidine kinase
L6178_23975	COG2267	carboxylic ester hydrolase activity
L6178_23995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6178_24000	COG1116	anion transmembrane transporter activity
L6178_24005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6178_24030	COG0494	nUDIX hydrolase
L6178_24065	COG0288	reversible hydration of carbon dioxide
L6178_24070	COG1271	oxidase subunit
L6178_24075	COG1294	oxidase, subunit
L6178_24095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_24120	COG1842	Phage shock protein A
L6178_24150	COG5002	protein histidine kinase activity
L6178_24155	COG0745	RESPONSE REGULATOR receiver
L6178_24185	COG1597	lipid kinase activity
L6178_24220	COG0586	Pfam SNARE associated Golgi protein
L6178_24230	COG0577	efflux transmembrane transporter activity
L6178_24235	COG1136	(ABC) transporter
L6178_24240	COG2207	Transcriptional regulator
L6178_24240	COG3708	Transcriptional regulator
L6178_24245	COG0745	RESPONSE REGULATOR receiver
L6178_24250	COG2205	protein histidine kinase activity
L6178_24260	COG0577	efflux transmembrane transporter activity
L6178_24265	COG1136	(ABC) transporter
L6178_24285	COG2188	Transcriptional regulator
L6178_24305	COG3964	amidohydrolase
L6178_24335	COG4948	Mandelate Racemase Muconate Lactonizing
L6178_24345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6178_24350	COG0596	Alpha beta hydrolase
L6178_24355	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6178_24360	COG1169	isochorismate synthase
L6178_24365	COG1575	Belongs to the MenA family. Type 1 subfamily
L6178_24370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6178_24390	COG0058	SHG alpha-glucan phosphorylase activity
L6178_24395	COG0297	glycogen (starch) synthase activity
L6178_24400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6178_24515	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6178_24550	COG1285	pathogenesis
L6178_24555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6178_24565	COG0166	Belongs to the GPI family
L6178_24570	COG2155	Conserved Protein
L6178_24575	COG1098	S1 RNA binding domain
L6178_24580	COG0436	Aminotransferase
L6178_24585	COG1522	sequence-specific DNA binding
L6178_24590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6178_24595	COG2267	carboxylic ester hydrolase activity
L6178_24605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6178_24625	COG5018	Exonuclease
L6178_24630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_24650	COG2050	protein possibly involved in aromatic compounds catabolism
L6178_24660	COG1268	BioY protein
L6178_24670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6178_24675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6178_24690	COG3584	3D domain protein
L6178_24705	COG1252	NADH dehydrogenase
L6178_24720	COG3708	Transcriptional regulator
L6178_24735	COG1683	Conserved Protein
L6178_24755	COG0316	Belongs to the HesB IscA family
L6178_24770	COG1252	NADH dehydrogenase
L6178_24785	COG0390	transport system, permease component
L6178_24790	COG2824	Alkylphosphonate utilization operon protein PhnA
L6178_24830	COG4837	Protein of unknown function (DUF1462)
L6178_24835	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6178_24845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6178_24850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6178_24860	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6178_24865	COG0647	UMP catabolic process
L6178_24875	COG2445	Protein of unknown function DUF86
L6178_24880	COG1494	fructose-1,6-bisphosphatase
L6178_24895	COG4470	Protein conserved in bacteria
L6178_24905	COG0789	Transcriptional regulator
L6178_24910	COG4377	Putative membrane peptidase family (DUF2324)
L6178_24935	COG0739	heme binding
L6178_24945	COG3377	Domain of unknown function (DUF1805)
L6178_24950	COG0737	Belongs to the 5'-nucleotidase family
L6178_24955	COG1695	Transcriptional regulator
L6178_24965	COG0719	Fe-S assembly protein
L6178_24970	COG0822	iron-sulfur transferase activity
L6178_24975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6178_24980	COG0719	Fe-S assembly protein
L6178_24985	COG0396	ATPase activity
L6178_24990	COG1464	Belongs to the NlpA lipoprotein family
L6178_24995	COG1464	Belongs to the NlpA lipoprotein family
L6178_25000	COG2011	ABC-type metal ion transport system permease component
L6178_25005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6178_25015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6178_25020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6178_25030	COG1393	Belongs to the ArsC family
L6178_25075	COG0039	L-malate dehydrogenase activity
L6178_25100	COG1309	transcriptional regulator
L6178_25105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6178_25110	COG1960	acyl-CoA dehydrogenase activity
L6178_25115	COG0183	Belongs to the thiolase family
L6178_25120	COG1024	Enoyl-CoA hydratase
L6178_25120	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6178_25130	COG1686	Belongs to the peptidase S11 family
L6178_25145	COG0011	TIGRFAM Protein of
L6178_25150	COG0840	transmembrane signaling receptor activity
L6178_25170	COG2814	Major facilitator Superfamily
L6178_25175	COG0531	amino acid
L6178_25185	COG0706	membrane insertase activity
L6178_25195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6178_25230	COG0586	Pfam SNARE associated Golgi protein
L6178_25240	COG1376	ErfK ybiS ycfS ynhG family protein
L6178_25250	COG5002	protein histidine kinase activity
L6178_25275	COG2151	metal-sulfur cluster biosynthetic enzyme
L6178_25280	COG3227	Zinc metalloprotease (Elastase)
L6178_25285	COG1741	Belongs to the pirin family
L6178_25300	COG0475	glutathione-regulated potassium exporter activity
L6178_25305	COG0490	domain, Protein
L6178_25310	COG1115	amino acid carrier protein
L6178_25315	COG0783	Belongs to the Dps family
L6178_25330	COG1611	Belongs to the LOG family
L6178_25350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_25355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_25360	COG1115	amino acid carrier protein
L6178_25365	COG1115	amino acid carrier protein
L6178_25370	COG2910	NAD(P)H-binding
L6178_25385	COG0656	L-ascorbic acid biosynthetic process
L6178_25390	COG2814	Major facilitator Superfamily
L6178_25395	COG1733	regulation of RNA biosynthetic process
L6178_25405	COG1252	NADH dehydrogenase
L6178_25410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6178_25415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6178_25425	COG3290	protein histidine kinase activity
L6178_25425	COG0840	transmembrane signaling receptor activity
L6178_25435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6178_25440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6178_25455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6178_25510	COG0557	exoribonuclease II activity
L6178_25515	COG1647	Serine aminopeptidase, S33
L6178_25520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6178_25525	COG1346	cytolysis
L6178_25620	COG4695	Portal protein
L6178_25645	COG4974	Belongs to the 'phage' integrase family
L6178_25655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6178_25660	COG0149	triose-phosphate isomerase activity
L6178_25670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6178_25685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6178_25710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6178_25725	COG2323	membrane
L6178_25730	COG0740	serine-type endopeptidase activity
L6178_25735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6178_25745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6178_25755	COG1051	belongs to the nudix hydrolase family
L6178_25765	COG0492	ferredoxin-NADP+ reductase activity
L6178_25770	COG0457	Tetratricopeptide repeat
L6178_25775	COG0110	maltose O-acetyltransferase activity
L6178_25795	COG1950	PFAM Membrane protein of
L6178_25805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6178_25810	COG0556	nucleotide-excision repair
L6178_25830	COG0789	Transcriptional regulator
L6178_25855	COG2855	membrane
L6178_25860	COG0583	DNA-binding transcription factor activity
L6178_25870	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6178_25875	COG0488	(ABC) transporter
L6178_25885	COG1132	(ABC) transporter
L6178_25890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_25895	COG3409	Peptidoglycan-binding domain 1 protein
L6178_25895	COG0793	Belongs to the peptidase S41A family
L6178_25900	COG2177	Part of the ABC transporter FtsEX involved in
L6178_25905	COG2884	Cell division ATP-binding protein ftsE
L6178_25920	COG0653	protein targeting
L6178_25925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6178_25930	COG1278	Cold shock
L6178_25935	COG1040	competence protein
L6178_25940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6178_25945	COG1388	LysM domain
L6178_25945	COG0791	NLP P60 protein
L6178_25950	COG1733	regulation of RNA biosynthetic process
L6178_25955	COG1307	EDD domain protein, DegV family
L6178_25960	COG1739	Uncharacterized protein family UPF0029
L6178_25965	COG1316	TRANSCRIPTIONal
L6178_25970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6178_25975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6178_25980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6178_25990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6178_25990	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6178_26005	COG3394	polysaccharide catabolic process
L6178_26010	COG1486	melibiose metabolic process
L6178_26015	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_26020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_26030	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6178_26035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6178_26040	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6178_26050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6178_26055	COG1301	dicarboxylic acid transport
L6178_26065	COG0346	lactoylglutathione lyase activity
L6178_26070	COG1511	domain protein
L6178_26075	COG0583	DNA-binding transcription factor activity
L6178_26080	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6178_26095	COG1271	oxidase subunit
L6178_26100	COG1294	oxidase, subunit
L6178_26105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6178_26115	COG1620	l-lactate permease
L6178_26125	COG2389	metal-binding protein
L6178_26135	COG1368	sulfuric ester hydrolase activity
L6178_26150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6178_26165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_26170	COG1388	LysM domain
L6178_26170	COG3584	3D domain protein
L6178_26195	COG4715	Zinc finger, swim domain protein
L6178_26200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6178_26240	COG0577	efflux transmembrane transporter activity
L6178_26245	COG1136	(ABC) transporter
L6178_26280	COG5002	protein histidine kinase activity
L6178_26285	COG0745	RESPONSE REGULATOR receiver
L6178_26290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6178_26310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6178_26315	COG1134	teichoic acid transport
L6178_26320	COG1682	transport, permease protein
L6178_26325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L6178_26370	COG1609	Transcriptional regulator
L6178_26385	COG0739	heme binding
L6178_26405	COG2385	sporulation resulting in formation of a cellular spore
L6178_26420	COG4836	Membrane
L6178_26425	COG1007	ATP synthesis coupled electron transport
L6178_26430	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6178_26435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6178_26445	COG0839	Belongs to the complex I subunit 6 family
L6178_26460	COG0649	NAD binding
L6178_26465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6178_26480	COG3300	MHYT domain
L6178_26480	COG5001	Diguanylate cyclase
L6178_26530	COG0356	it plays a direct role in the translocation of protons across the membrane
L6178_26565	COG0698	ribose 5-phosphate isomerase
L6178_26575	COG2190	(PTS) system
L6178_26580	COG2259	Doxx family
L6178_26585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6178_26600	COG0009	L-threonylcarbamoyladenylate synthase
L6178_26615	COG2890	protein-(glutamine-N5) methyltransferase activity
L6178_26635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6178_26640	COG1494	fructose-1,6-bisphosphatase
L6178_26660	COG4821	SIS domain
L6178_26670	COG3343	RNA polymerase activity
L6178_26680	COG1960	acyl-CoA dehydrogenase activity
L6178_26685	COG1960	acyl-CoA dehydrogenase activity
L6178_26690	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6178_26695	COG0183	Belongs to the thiolase family
L6178_26700	COG2181	nitrate reductase activity
L6178_26700	COG0247	lactate metabolic process
L6178_26705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6178_26715	COG5001	Diguanylate cyclase
L6178_26715	COG3300	MHYT domain
L6178_26735	COG2197	response regulator
L6178_26740	COG4585	Histidine kinase
L6178_26745	COG0842	Transport permease protein
L6178_26750	COG1131	(ABC) transporter
L6178_26755	COG0024	Methionine aminopeptidase
L6178_26765	COG2234	aminopeptidase activity
L6178_26785	COG1595	DNA-templated transcription, initiation
L6178_26790	COG0018	arginyl-trna synthetase
L6178_26795	COG4506	Protein conserved in bacteria
L6178_26800	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6178_26815	COG0010	Belongs to the arginase family
L6178_26825	COG2814	Major facilitator Superfamily
L6178_26830	COG0789	Transcriptional regulator
L6178_26835	COG0584	glycerophosphoryl diester phosphodiesterase
L6178_26840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6178_26850	COG1994	Peptidase M50
L6178_26860	COG1078	dGTPase activity
L6178_26865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6178_26870	COG1120	ATPase activity
L6178_26875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6178_26900	COG0095	Lipoate-protein ligase
L6178_26905	COG0280	phosphate acetyltransferase
L6178_26920	COG3773	Cell wall hydrolase
L6178_26930	COG2363	Small membrane protein
L6178_26945	COG2233	PERMEase
L6178_26950	COG0561	phosphatase activity
L6178_26955	COG2814	Major facilitator Superfamily
L6178_26965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6178_26970	COG1131	(ABC) transporter
L6178_26975	COG2755	lipolytic protein G-D-S-L family
L6178_26980	COG1609	Transcriptional regulator
L6178_26990	COG0460	homoserine dehydrogenase
L6178_27000	COG2873	o-acetylhomoserine
L6178_27010	COG1011	Hydrolase
L6178_27015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6178_27025	COG2197	response regulator
L6178_27035	COG0351	phosphomethylpyrimidine kinase
L6178_27040	COG3706	GGDEF domain
L6178_27045	COG2879	small protein
L6178_27050	COG1966	Carbon starvation protein
L6178_27055	COG3279	Response regulator of the LytR AlgR family
L6178_27060	COG0477	Major facilitator Superfamily
L6178_27085	COG0840	transmembrane signaling receptor activity
L6178_27095	COG1607	acyl-coa hydrolase
L6178_27110	COG0488	(ABC) transporter
L6178_27130	COG0463	Glycosyl transferase, family 2
L6178_27135	COG1309	transcriptional regulator
L6178_27140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6178_27145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_27145	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6178_27150	COG0628	permease
L6178_27165	COG3279	Response regulator of the LytR AlgR family
L6178_27170	COG3275	phosphorelay sensor kinase activity
L6178_27175	COG2814	Major facilitator Superfamily
L6178_27180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6178_27185	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6178_27190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6178_27210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6178_27215	COG1272	protein, Hemolysin III
L6178_27235	COG0516	GMP reductase activity
L6178_27240	COG1164	Oligoendopeptidase f
L6178_27260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6178_27265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6178_27270	COG4853	Protein conserved in bacteria
L6178_27275	COG4863	YycH protein
L6178_27280	COG5002	protein histidine kinase activity
L6178_27285	COG0745	RESPONSE REGULATOR receiver
L6178_27315	COG0305	Participates in initiation and elongation during chromosome replication
L6178_27325	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6178_27330	COG4241	membrane
L6178_27340	COG0629	single-stranded DNA binding
L6178_27350	COG0012	GTP binding
L6178_27355	COG4481	Protein conserved in bacteria
L6178_27360	COG0668	transmembrane transport
L6178_27370	COG1475	DNA binding
L6178_27375	COG1192	Involved in chromosome partitioning
L6178_27400	COG1847	R3H domain protein
L6178_27405	COG0706	membrane insertase activity
L6178_27415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6178_27450	COG0791	NLP P60 protein
L6178_27450	COG0741	lytic transglycosylase activity
L6178_27605	COG1192	Involved in chromosome partitioning
L6178_27650	COG1683	Conserved Protein
L6178_27655	COG1309	transcriptional regulator
L6178_27730	COG0681	Belongs to the peptidase S26 family
L6178_27760	COG1280	lysine exporter protein (LysE YggA)
L6178_27805	COG4166	transmembrane transport
L6178_27815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII