locus-tag class description FOC06_00010 ENOG4105CH6 catalase FOC06_00020 ENOG4105D5Q Arginine ornithine antiporter FOC06_00025 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC06_00035 ENOG4105C26 Dehydrogenase FOC06_00040 ENOG4105BZ1 (ABC) transporter FOC06_00055 ENOG4105DRP amino acid AbC transporter FOC06_00060 ENOG4105CDA abc transporter atp-binding protein FOC06_00075 ENOG410839P FOC06_00110 ENOG4107FQX Alpha-acetolactate decarboxylase FOC06_00140 ENOG4105D4P Coproporphyrinogen iii oxidase FOC06_00155 ENOG4105CHH sulfate transporter FOC06_00195 ENOG4106AKK s-layer domain-containing protein FOC06_00205 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_00210 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_00225 ENOG4105CGU Enoyl-CoA hydratase FOC06_00245 ENOG4105DER m42 family FOC06_00265 ENOG4105CTU Proline racemase FOC06_00305 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_00315 ENOG4108JQ7 (ABC) transporter FOC06_00320 ENOG4105PKS Excinuclease abc c subunit domain protein FOC06_00350 ENOG4105CSH Transporter FOC06_00360 ENOG4108MRH transcriptional regulatory protein FOC06_00410 ENOG4105CDU Replicative dna helicase FOC06_00440 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_00485 ENOG4107P5I polyketide synthase FOC06_00490 ENOG4108IG5 Transcriptional regulator FOC06_00510 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC06_00530 ENOG4105CMT Dihydroxyacetone kinase FOC06_00540 ENOG4105CMT Dihydroxyacetone kinase FOC06_00545 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC06_00550 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC06_00580 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC06_00645 ENOG4105WN5 stage II sporulation protein FOC06_00655 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_00665 ENOG4108MJI response regulator FOC06_00670 ENOG4105BZU Histidine kinase FOC06_00675 ENOG4105BZU Histidine kinase FOC06_00695 ENOG4105K8R UPF0145 protein FOC06_00725 ENOG4107VRP DNA repair exonuclease FOC06_00735 ENOG4105D7V transposase FOC06_00750 ENOG4108IND Tetr family transcriptional regulator FOC06_00755 ENOG4105EQ0 Major Facilitator superfamily FOC06_00775 ENOG4108MUZ hydrolase FOC06_00795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC06_00810 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC06_00820 ENOG4105EMN RNA polymerase sigma factor FOC06_00845 ENOG4105C57 major facilitator superfamily FOC06_00850 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_00860 ENOG4105EEM helicase FOC06_00890 ENOG4105K59 histidine triad (HIT) protein FOC06_00920 ENOG410905X membrane-flanked domain protein FOC06_00965 ENOG410905X membrane-flanked domain protein FOC06_00970 ENOG4105CKV Membrane FOC06_00975 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC06_00980 ENOG4105BZ4 penicillin-binding protein FOC06_00985 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC06_00995 ENOG4105C1Q protoporphyrinogen oxidase FOC06_01020 ENOG4105NA0 Transcriptional regulator FOC06_01035 ENOG4105ECB domain protein FOC06_01065 ENOG4106AXD FOC06_01070 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC06_01075 ENOG4105DF9 Lipoate-protein, ligase FOC06_01085 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_01115 ENOG4105CNA YD repeat protein FOC06_01150 ENOG4107TVP HD domain protein FOC06_01160 ENOG4108AEY RNA polymerase sigma factor FOC06_01165 ENOG41086D8 Transcriptional regulator FOC06_01180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_01205 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC06_01210 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_01230 ENOG4105ZU5 s-layer protein FOC06_01235 ENOG4107QP3 malate synthase g FOC06_01250 ENOG4105VEQ Cold shock protein FOC06_01265 ENOG4105XVF Competence transcription factor FOC06_01280 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC06_01285 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC06_01330 ENOG4105ERH Fumarylacetoacetate hydrolase FOC06_01355 ENOG4105CAQ asparagine synthetase FOC06_01360 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC06_01365 ENOG4105CH6 catalase FOC06_01390 ENOG4105QNR S1 RNA binding domain protein FOC06_01400 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC06_01410 ENOG4107AYK membrAne FOC06_01415 ENOG41073B9 FOC06_01425 ENOG4108KP7 hydrolase FOC06_01435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC06_01460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_01465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC06_01480 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC06_01495 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_01500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_01510 ENOG4108JQ7 (ABC) transporter FOC06_01515 ENOG4105UQX Mate efflux family protein FOC06_01535 ENOG4108ZCF integral membrane protein FOC06_01545 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_01555 ENOG4105DPN Oligoendopeptidase f FOC06_01565 ENOG4108Z18 K06886 hemoglobin FOC06_01570 ENOG4105MIX Adenylate cyclase FOC06_01585 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC06_01590 ENOG4105EMS pseudouridine synthase FOC06_01610 ENOG4105K64 Glycosyl transferase, family 2 FOC06_01630 ENOG4107TVC Glycosyl transferase, family 2 FOC06_01650 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC06_01655 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC06_01665 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC06_01715 ENOG4108WVJ 2'-5' rna ligase FOC06_01740 ENOG4105CK7 Sodium proline symporter FOC06_01750 ENOG4105DDQ anthranilate synthase FOC06_01845 ENOG4105C7S Dehydrogenase FOC06_01855 ENOG4105VZ8 Transcriptional regulator FOC06_01915 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC06_01925 ENOG4105DZ1 carboxypeptidase FOC06_01930 ENOG4105VFR signal peptidase FOC06_01965 ENOG4105C26 Dehydrogenase FOC06_01970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_01975 ENOG4105F38 ABC transporter, permease FOC06_01980 ENOG4105D38 putrescine abc transporter FOC06_01985 ENOG4107RUE extracellular solute-binding protein family 1 FOC06_01995 ENOG4105EYF MMPL domain protein FOC06_02005 ENOG4108YBP pseudouridine synthase FOC06_02015 ENOG4105K4I Scp-like extracellular FOC06_02020 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC06_02025 ENOG4105CQB FAD linked oxidase domain protein FOC06_02040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_02045 ENOG4105BZU Histidine kinase FOC06_02050 ENOG4105JXH GntR family transcriptional regulator FOC06_02070 ENOG4106A3R peptidase FOC06_02080 ENOG4108QTI )-transporter FOC06_02085 ENOG4107TS3 membrane protein, TerC FOC06_02090 ENOG4105CZN Potassium uptake protein FOC06_02095 ENOG410681C small acid-soluble spore protein FOC06_02100 ENOG4108Z7G MaoC domain protein dehydratase FOC06_02120 ENOG4105CHR reductase FOC06_02130 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC06_02145 ENOG4105C4Y ABC transporter FOC06_02160 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC06_02175 ENOG4105E98 transcriptional regulator DeoR family FOC06_02195 ENOG4105PXI polysaccharide deacetylase FOC06_02205 ENOG4105BZU Histidine kinase FOC06_02210 ENOG41090MY MarR family Transcriptional regulator FOC06_02220 ENOG4106DF1 FOC06_02225 ENOG4105BZU Histidine kinase FOC06_02235 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC06_02240 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC06_02275 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC06_02295 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC06_02300 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC06_02305 ENOG4105CZV ABC transporter FOC06_02315 ENOG4105CJ1 ABC, transporter FOC06_02355 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC06_02360 ENOG4105EA8 2-Nitropropane dioxygenase FOC06_02365 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC06_02375 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC06_02395 ENOG4105NQC Flavodoxin FOC06_02420 ENOG4107QMU Mate efflux family protein FOC06_02425 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_02455 ENOG4105CZN Potassium uptake protein FOC06_02460 ENOG41063Y9 FOC06_02465 ENOG4105KBJ sporulation protein ytfj FOC06_02490 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC06_02495 ENOG4105C7K acetolactate synthase FOC06_02500 ENOG4108ZP8 Acetolactate synthase small subunit FOC06_02505 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC06_02515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC06_02540 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC06_02575 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC06_02590 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC06_02595 ENOG4105E0M Sulfatase FOC06_02605 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC06_02625 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC06_02630 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC06_02640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC06_02645 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC06_02650 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC06_02655 ENOG4105C8J )-transporter FOC06_02675 ENOG4105DFD Na H antiporter FOC06_02695 ENOG4105ENE Histidine kinase FOC06_02700 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_02720 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC06_02745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC06_02765 ENOG4105CJ3 phosphate transporter FOC06_02770 ENOG4107GRR phosphate transport regulator FOC06_02775 ENOG4105BZ4 penicillin-binding protein FOC06_02795 ENOG4105I3N Conserved Protein FOC06_02810 ENOG4105BZU Histidine kinase FOC06_02845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_02850 ENOG4105DZ1 carboxypeptidase FOC06_02855 ENOG4108JIC nucleoside recognition domain protein FOC06_02865 ENOG4105FE9 pseudouridine synthase FOC06_02875 ENOG4107TWT Cytochrome c biogenesis protein FOC06_02880 ENOG4105CRE cytochrome C FOC06_02885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_02890 ENOG4105BZU Histidine kinase FOC06_02895 ENOG4108WBT adenosyltransferase FOC06_02910 ENOG4108SAX Membrane FOC06_02920 ENOG4105T7X FOC06_02925 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC06_02930 ENOG4105I7S Abortive infection protein FOC06_02945 ENOG4107X2D transcriptional regulator, merr family FOC06_02950 ENOG4108S6Z Negative regulator of genetic competence FOC06_02975 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC06_02980 ENOG4105HDK L-asparaginase FOC06_03015 ENOG4105S2F FOC06_03020 ENOG41065D1 FOC06_03050 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC06_03065 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC06_03075 ENOG4105EAH synthase FOC06_03095 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC06_03100 ENOG41068YB TPR repeat-containing protein FOC06_03115 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC06_03120 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC06_03125 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC06_03155 ENOG4108JYZ YitT family FOC06_03160 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC06_03175 ENOG4105FJR Lmbe family FOC06_03180 ENOG4105CPK Glycosyl transferase (Group 1 FOC06_03215 ENOG4105DVT helicase FOC06_03220 ENOG4105YAC FOC06_03240 ENOG4105CSM endonuclease III FOC06_03250 ENOG4105BZ4 penicillin-binding protein FOC06_03305 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC06_03315 ENOG4105DVT helicase FOC06_03320 ENOG4105CTD carboxy-peptidase FOC06_03335 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_03350 ENOG4105C2W permease FOC06_03355 ENOG4105DHF Membrane FOC06_03365 ENOG410890F Dynamin family FOC06_03375 ENOG4108W0I acetyltransferase FOC06_03385 ENOG4105KHC sulfurtransferase FOC06_03485 ENOG4108SZE gCN5-related N-acetyltransferase FOC06_03505 ENOG41081VK Ribonuclease FOC06_03570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_03580 ENOG4107RWR Sodium hydrogen exchanger FOC06_03590 ENOG4108Z5V transcriptional regulator, merr family FOC06_03600 ENOG4105H67 Protein of unknown function (DUF421) FOC06_03605 ENOG41080C8 DUF218 domain FOC06_03660 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC06_03670 ENOG4107R0U MotA TolQ exbB proton channel FOC06_03675 ENOG4105ER2 Ompa motb domain protein FOC06_03680 ENOG4107YTP response regulator receiver protein FOC06_03690 ENOG4105DD5 Flagellar motor switch protein FOC06_03705 ENOG4105BZU Histidine kinase FOC06_03725 ENOG4105E1Q flagellar hook-associated protein FOC06_03750 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC06_03755 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC06_03760 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC06_03770 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC06_03805 ENOG4105BZE flagellar hook protein, FlgE FOC06_03830 ENOG4105K64 Glycosyl transferase, family 2 FOC06_03870 ENOG4105I03 Flagellin FOC06_03875 ENOG4105E4C Lytic transglycosylase catalytic FOC06_03890 ENOG4105DD5 Flagellar motor switch protein FOC06_03900 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC06_03905 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC06_03915 ENOG4105D00 flagellar biosynthetic protein flhB FOC06_03920 ENOG4105D7B Flagellar biosynthesis protein flha FOC06_03930 ENOG4105KTQ flagellar basal-body rod protein FOC06_03935 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_03960 ENOG4108RZE Tetr family transcriptional regulator FOC06_03980 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC06_04005 ENOG4105DUM transcriptional regulator, lysR family FOC06_04010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_04015 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC06_04020 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC06_04025 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC06_04065 ENOG4105CVJ phosphoglycerate mutase FOC06_04095 ENOG4105CAQ asparagine synthetase FOC06_04115 ENOG4105PGM cation diffusion facilitator family transporter FOC06_04125 ENOG4105DRR Transcriptional regulator, GntR family FOC06_04130 ENOG4108UZ3 Transporter FOC06_04135 ENOG4105CKI cobalamin synthesis protein FOC06_04140 ENOG4108PJD permease FOC06_04155 ENOG4105DFD Na H antiporter FOC06_04160 ENOG4105C9Q fumarate hydratase class II FOC06_04185 ENOG4105EC3 peptidase S51, dipeptidase E FOC06_04205 ENOG4107QIV Cytochrome c biogenesis protein FOC06_04235 ENOG4106BRA Membrane FOC06_04270 ENOG4105CJ1 ABC, transporter FOC06_04290 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC06_04300 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_04305 ENOG4105C6K Malic enzyme FOC06_04365 ENOG4105FVX FOC06_04405 ENOG4105CSR polyphosphate kinase 2 FOC06_04435 ENOG4105EU0 Major facilitator Superfamily FOC06_04440 ENOG4105C6T cysteine synthase FOC06_04460 ENOG4105C8J )-transporter FOC06_04470 ENOG4105X5K response regulator receiver protein FOC06_04475 ENOG4105H67 Protein of unknown function (DUF421) FOC06_04490 ENOG4106KE4 Dehydrogenase FOC06_04505 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC06_04510 ENOG4105CHR reductase FOC06_04515 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC06_04520 ENOG4105C7K acetolactate synthase FOC06_04525 ENOG4108ZP8 Acetolactate synthase small subunit FOC06_04530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC06_04540 ENOG4105C7B Threonine dehydratase FOC06_04565 ENOG4105C6X Major Facilitator FOC06_04570 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC06_04580 ENOG4105DY9 regulatoR FOC06_04585 ENOG4105CYC Transferase FOC06_04605 ENOG4105F6J Alpha beta hydrolase fold FOC06_04640 ENOG41068WN FOC06_04660 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC06_04665 ENOG4105C72 UPF0176 protein FOC06_04675 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC06_04705 ENOG4107RHR regulatoR FOC06_04715 ENOG4105D9N nucleoside FOC06_04720 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC06_04755 ENOG4107RAQ aminopeptidase FOC06_04760 ENOG4107STQ Multicopper oxidase FOC06_04805 ENOG4108T5E Copper resistance protein FOC06_04810 ENOG4105KTB nuclear export factor GLE1 FOC06_04820 ENOG4107RT3 EamA-like transporter family FOC06_04825 ENOG4105GZI Transcriptional regulator FOC06_04830 ENOG4108Z40 Transcriptional regulator FOC06_04835 ENOG4107ZXU DSBA oxidoreductase FOC06_04840 ENOG4108TVJ Nitroreductase FOC06_04845 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC06_04850 ENOG4106F5Q Membrane FOC06_04855 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_04865 ENOG4105CKI cobalamin synthesis protein FOC06_04885 ENOG4108Z7G MaoC domain protein dehydratase FOC06_04890 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_04900 ENOG4105C0Z ABC transporter FOC06_04905 ENOG4108IV0 ABC, transporter FOC06_04910 ENOG4105C32 Amino acid ABC transporter (Permease) FOC06_04920 ENOG4105SKE transcriptional Regulator LysR family FOC06_04940 ENOG4105YGB Transcriptional regulator FOC06_04950 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC06_04955 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC06_04960 ENOG4108JJ9 ABC, transporter FOC06_04965 ENOG4108JJ8 (ABC) transporter FOC06_05015 ENOG4105EFI regulatoR FOC06_05020 ENOG4105BZU Histidine kinase FOC06_05040 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC06_05045 ENOG4108ZJ4 polysaccharide deacetylase FOC06_05065 ENOG4105D6E homoserine dehydrogenase FOC06_05090 ENOG4108KGH TRANSCRIPTIONal FOC06_05100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_05105 ENOG4105BZU Histidine kinase FOC06_05110 ENOG4107VMI polysaccharide deacetylase FOC06_05120 ENOG4105KT7 mgtC SapB transporter FOC06_05125 ENOG4105VRR gCN5-related N-acetyltransferase FOC06_05135 ENOG4105DUU IucA IucC family protein FOC06_05140 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_05155 ENOG4108WBH protein TIM barrel FOC06_05160 ENOG4105YWU small acid-soluble spore protein FOC06_05170 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC06_05220 ENOG4105KRN Transcriptional regulator, abrb family FOC06_05230 ENOG4105YVS arsR family transcriptional regulator FOC06_05235 ENOG4107SET aldo keto reductase FOC06_05240 ENOG4107XZQ multidrug resistance protein FOC06_05265 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_05280 ENOG4108K88 Membrane FOC06_05285 ENOG4108WPJ Ferritin-like domain FOC06_05300 ENOG4105DEN Luciferase family FOC06_05320 ENOG4107QM2 Aldo Keto reductase FOC06_05325 ENOG4105CKI cobalamin synthesis protein FOC06_05380 ENOG4105DSE periplasmic solute binding protein FOC06_05385 ENOG4105K4T epimerase FOC06_05395 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC06_05420 ENOG4105CVJ phosphoglycerate mutase FOC06_05440 ENOG4107T5V SNARE associated Golgi FOC06_05455 ENOG4108PJD permease FOC06_05465 ENOG4108S4H thioesterase Superfamily protein FOC06_05475 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_05495 ENOG4105SXS Protein of unknown function (DUF456) FOC06_05500 ENOG4105C37 (CBS) domain FOC06_05520 ENOG4108Z7R Chaperone CsaA FOC06_05540 ENOG4108ZRV stage ii sporulation protein p FOC06_05550 ENOG4108VXD carboxy-peptidase FOC06_05560 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC06_05585 ENOG4108X4Q Hydrolase FOC06_05595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC06_05600 ENOG4107RBS Methyltransferase FOC06_05615 ENOG41087PP glycosyltransferase MGT family FOC06_05620 ENOG4108JYZ YitT family FOC06_05625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC06_05650 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC06_05700 ENOG4105KBJ sporulation protein ytfj FOC06_05725 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC06_05750 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_05760 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC06_05765 ENOG4105EMN RNA polymerase sigma factor FOC06_05790 ENOG4108V06 Glutathione peroxidase FOC06_05805 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_05825 ENOG4108IUE nitrate reductase beta subunit FOC06_05830 ENOG4105R3A Nitrate reductase FOC06_05855 ENOG4107V6Q Cyclic nucleotide-binding domain FOC06_05860 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC06_05865 ENOG4105D06 uba thif-type nad fad binding protein FOC06_05870 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_05875 ENOG4108ZAF Molybdopterin FOC06_05900 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC06_05905 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC06_05910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC06_05915 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC06_05920 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC06_05925 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC06_05960 ENOG4105MCT stage V sporulation protein S FOC06_05975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC06_05995 ENOG4105C5H ABC transporter FOC06_06010 ENOG4108UUM single-stranded DNA-binding protein FOC06_06040 ENOG4107YX5 Pfam:DUF548 FOC06_06045 ENOG4105C75 arginyL-tRNA synthetase FOC06_06070 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC06_06090 ENOG4105C5S asparaginyl-tRNA synthetase FOC06_06110 ENOG4105EC2 ftsk spoIIIe FOC06_06180 ENOG4105BZW Glycerate kinase FOC06_06185 ENOG4107QPK )-transporter FOC06_06190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_06195 ENOG41062D9 Histidine kinase FOC06_06210 ENOG4105C8J )-transporter FOC06_06230 ENOG4107XGZ Hydrolase FOC06_06235 ENOG4105CY2 Citrate transporter FOC06_06240 ENOG4105C0A alcohol dehydrogenase FOC06_06255 ENOG4105KD7 acetyltransferase FOC06_06285 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC06_06305 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC06_06320 ENOG4107RVG penicillin-binding protein FOC06_06325 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC06_06330 ENOG4105E9Q Acyl-transferase FOC06_06335 ENOG4108UT2 hemolysin iii FOC06_06345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC06_06355 ENOG4108RCR degv family FOC06_06360 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC06_06365 ENOG4108KF3 Electron transport protein SCO1 SenC FOC06_06370 ENOG4107Y70 Heat shock protein FOC06_06375 ENOG4105CAQ asparagine synthetase FOC06_06390 ENOG4108MES Periplasmic binding protein FOC06_06395 ENOG4105F0I Aminotransferase FOC06_06430 ENOG4105D8X mechanosensitive ion channel FOC06_06435 ENOG4105BZU Histidine kinase FOC06_06440 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_06475 ENOG4105CMG Carbohydrate kinase FOC06_06480 ENOG4105CMG Carbohydrate kinase FOC06_06510 ENOG4108IJ8 ABC transporter FOC06_06515 ENOG4105E90 ABC transporter FOC06_06550 ENOG4105C37 (CBS) domain FOC06_06575 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_06590 ENOG4107S4Y M20 DapE family protein YgeY FOC06_06595 ENOG4108TSC N-acetyltransferase FOC06_06600 ENOG4108JUB Transcriptional regulator FOC06_06605 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC06_06645 ENOG4108N23 SpoOM-related protein FOC06_06650 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC06_06660 ENOG4105SZ6 Thioredoxin FOC06_06675 ENOG4108IBT Inherit from COG: transposase FOC06_06780 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC06_06820 ENOG4105BZ4 penicillin-binding protein FOC06_06825 ENOG4105CZM Major Facilitator FOC06_06830 ENOG4105W8X HesB YadR YfhF-family protein FOC06_06840 ENOG4105DXD 2-methylcitrate dehydratase FOC06_06845 ENOG4105CR4 methylisocitrate lyase FOC06_06850 ENOG4105C1G acyl-Coa dehydrogenase FOC06_06855 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC06_06865 ENOG4105N14 lysine exporter protein LysE YggA FOC06_06870 ENOG4105E39 Enoyl-CoA hydratase FOC06_06885 ENOG4107RFY SbcCD D subunit FOC06_06890 ENOG4105EYH Exonuclease FOC06_06910 ENOG4105FCD Major Facilitator FOC06_06915 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC06_06920 ENOG4105E4F Isochorismate synthase FOC06_06925 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC06_06930 ENOG4105WQI isochorismatase FOC06_06935 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_06940 ENOG4105WQT MbtH domain protein FOC06_06945 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_06960 ENOG4105K70 DNA-binding protein FOC06_06980 ENOG4105BZG amino acid carrier protein FOC06_07000 ENOG4105FE9 pseudouridine synthase FOC06_07005 ENOG4105C22 threonyL-tRNA synthetase FOC06_07020 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC06_07045 ENOG4108D32 Methyltransferase FOC06_07075 ENOG41081I9 integral membrane protein FOC06_07090 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC06_07100 ENOG4105EYF MMPL domain protein FOC06_07125 ENOG4105WCN acetyltransferase FOC06_07155 ENOG4105C1Q protoporphyrinogen oxidase FOC06_07165 ENOG41068WN FOC06_07175 ENOG4105VEQ Cold shock protein FOC06_07195 ENOG410667J hydrolase FOC06_07235 ENOG4107V2S Transcriptional regulator FOC06_07240 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC06_07255 ENOG4105DND Transcriptional regulator FOC06_07260 ENOG4108RPX mosc domain containing protein FOC06_07275 ENOG4105BZ1 (ABC) transporter FOC06_07280 ENOG4105BZ1 (ABC) transporter FOC06_07300 ENOG4108JCI Transcriptional regulator FOC06_07330 ENOG4108KPJ rna polymerase sigma factor FOC06_07380 ENOG4105RD7 BadF BadG BcrA BcrD FOC06_07390 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC06_07410 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC06_07425 ENOG4105C1J atp-dependent rna helicase FOC06_07440 ENOG4108RZE Tetr family transcriptional regulator FOC06_07460 ENOG41088CC tellurite resistance protein tehB FOC06_07470 ENOG4108I0C methyltransferase FOC06_07475 ENOG4107RA9 decarboxylase FOC06_07480 ENOG41090HR transcriptional regulator FOC06_07510 ENOG4105CIN aminoacyl-histidine dipeptidase FOC06_07535 ENOG4107RF6 penicillin-binding protein FOC06_07550 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC06_07555 ENOG4105ETE Transcriptional regulator (LacI family FOC06_07560 ENOG4105IE8 Alpha-ketoglutarate permease FOC06_07565 ENOG4105CK5 oxidoreductase FOC06_07590 ENOG4105D2N Aldolase FOC06_07595 ENOG4105DH8 myo-inositol catabolism FOC06_07625 ENOG4105VZ8 Transcriptional regulator FOC06_07640 ENOG4108VXD carboxy-peptidase FOC06_07660 ENOG41067SE Tetr family transcriptional regulator FOC06_07665 ENOG4105C5H ABC transporter FOC06_07675 ENOG4105BZU Histidine kinase FOC06_07690 ENOG4106ANW SMI1_KNR4 FOC06_07695 ENOG4105CEP NADH dehydrogenase FOC06_07700 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC06_07715 ENOG4105CJ1 ABC, transporter FOC06_07725 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_07740 ENOG4105C1G acyl-Coa dehydrogenase FOC06_07745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC06_07750 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC06_07755 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC06_07760 ENOG4105E39 Enoyl-CoA hydratase FOC06_07765 ENOG4107QX3 carboxylase FOC06_07770 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC06_07780 ENOG4105WCN acetyltransferase FOC06_07785 ENOG4105DBI uridine monophosphokinase FOC06_07800 ENOG4105DZ1 carboxypeptidase FOC06_07815 ENOG4105T9C HD domain FOC06_07825 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC06_07865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_07865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_07880 ENOG4105FQP Beta-lactamase FOC06_07890 ENOG4107Y80 Major Facilitator superfamily FOC06_07910 ENOG4105CUV Homoserine Kinase FOC06_07945 ENOG4105CPQ Dehydrogenase FOC06_08050 ENOG4105ETU transcriptional activator (TenA FOC06_08150 ENOG410667J hydrolase FOC06_08160 ENOG4105BZU Histidine kinase FOC06_08165 ENOG4107RF6 penicillin-binding protein FOC06_08185 ENOG4108JJB ABC transporter FOC06_08200 ENOG4108HGU Histidine kinase FOC06_08215 ENOG4105CB2 alcohol dehydrogenase FOC06_08220 ENOG4105CJN penicillin-binding protein FOC06_08230 ENOG4105FQP Beta-lactamase FOC06_08265 ENOG4108V4B ThiJ pfpI FOC06_08295 ENOG4107Y80 Major Facilitator superfamily FOC06_08310 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC06_08330 ENOG4107Y9U Membrane FOC06_08360 ENOG4105FCD Major Facilitator FOC06_08375 ENOG4105E09 nadh pyrophosphatase FOC06_08380 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC06_08385 ENOG4108Z4K mutator MutT protein FOC06_08420 ENOG4108XI2 Domain of unknown function (DUF1963) FOC06_08450 ENOG4105KWG Pfam:DUF1696 FOC06_08485 ENOG4105PKS Excinuclease abc c subunit domain protein FOC06_08525 ENOG4107VFR oxidoreductase FOC06_08550 ENOG4105PAD Hydrolase FOC06_08570 ENOG4105DY8 decarboxylase FOC06_08585 ENOG4108IUM Glycogen debranching enzyme FOC06_08610 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC06_08620 ENOG4105FDR Membrane FOC06_08655 ENOG4108V3A UPF0421 protein FOC06_08675 ENOG4105MSI germination protein ypeb FOC06_08695 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC06_08700 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC06_08705 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC06_08710 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_08740 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC06_08755 ENOG4105E98 transcriptional regulator DeoR family FOC06_08775 ENOG41062ES Transcriptional regulator FOC06_08795 ENOG4107QKR Dehydrogenase FOC06_08805 ENOG4107RUY (E1 component), alpha subunit FOC06_08815 ENOG4105E1F short-chain dehydrogenase reductase FOC06_08820 ENOG4105RHY Pfam:UPF0157 FOC06_08850 ENOG4107SQ8 Glycine betaine FOC06_08855 ENOG4108IJ7 Glycine betaine FOC06_08880 ENOG4105E66 phosphoriboisomerase A FOC06_08885 ENOG41082BV acetyltransferase FOC06_08890 ENOG4108M1A Chitin-binding protein FOC06_08925 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC06_08975 ENOG4105EEM helicase FOC06_08995 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC06_09040 ENOG4108M1A Chitin-binding protein FOC06_09060 ENOG4105BZG amino acid carrier protein FOC06_09065 ENOG4105C26 Dehydrogenase FOC06_09070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC06_09075 ENOG4105CTU Proline racemase FOC06_09080 ENOG4105CTU Proline racemase FOC06_09085 ENOG41080HI glycine oxidase FOC06_09125 ENOG4107T5V SNARE associated Golgi FOC06_09140 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC06_09145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC06_09160 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_09205 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC06_09210 ENOG4105BZU Histidine kinase FOC06_09250 ENOG4105DPN Oligoendopeptidase f FOC06_09265 ENOG4105EPR degv family FOC06_09305 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC06_09310 ENOG4106K7D Major facilitator family transporter FOC06_09330 ENOG4107BMA Transglycosylase associated protein FOC06_09345 ENOG41089UC methyltransferase, type 11 FOC06_09380 ENOG4105CHM Aminotransferase FOC06_09450 ENOG4105C02 permease FOC06_09460 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC06_09465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC06_09470 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC06_09495 ENOG4105E09 nadh pyrophosphatase FOC06_09515 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC06_09565 ENOG4107VC0 DNA alkylation repair enzyme FOC06_09575 ENOG4107VMI polysaccharide deacetylase FOC06_09585 ENOG4108ZCF integral membrane protein FOC06_09590 ENOG4105E0M Sulfatase FOC06_09595 ENOG4105C5H ABC transporter FOC06_09605 ENOG4105EYF MMPL domain protein FOC06_09610 ENOG4105EYF MMPL domain protein FOC06_09615 ENOG4105EYF MMPL domain protein FOC06_09620 ENOG41082JN Transcriptional regulator FOC06_09640 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC06_09645 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC06_09650 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC06_09685 ENOG41069ER domain protein FOC06_09695 ENOG4105EMN RNA polymerase sigma factor FOC06_09720 ENOG4105D4B ABC, transporter FOC06_09730 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC06_09740 ENOG4105DKT Transcriptional regulator FOC06_09755 ENOG41061GT Aldolase FOC06_09775 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC06_09805 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC06_09810 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_09820 ENOG4107258 Transcriptional regulator FOC06_09830 ENOG4105E0Y RtcB Protein FOC06_09835 ENOG4105ECK Fatty Acid Desaturase FOC06_09840 ENOG4105G6Z alkaline phosphatase FOC06_09850 ENOG4105VMP Transcriptional regulator FOC06_09865 ENOG41090T1 Membrane FOC06_09875 ENOG4108WCX response regulator FOC06_09885 ENOG41068WN FOC06_09910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_09935 ENOG4105CKK Glycosyl transferase, family 2 FOC06_09960 ENOG4105CKK Glycosyl transferase, family 2 FOC06_09970 ENOG4105C8Y Acetylornithine aminotransferase FOC06_10010 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC06_10020 ENOG4108TVJ Nitroreductase FOC06_10025 ENOG4105FS7 Transcriptional regulator FOC06_10060 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_10070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC06_10100 ENOG4108XET gCN5-related N-acetyltransferase FOC06_10180 ENOG410635A Membrane FOC06_10185 ENOG4105KNA -acetyltransferase FOC06_10190 ENOG4108IQI permease FOC06_10200 ENOG4105F1N DNA alkylation repair FOC06_10250 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC06_10285 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC06_10290 ENOG4107258 Transcriptional regulator FOC06_10300 ENOG4106N3A copper homeostasis protein cutc FOC06_10305 ENOG4108ZRV stage ii sporulation protein p FOC06_10310 ENOG4108ZHR arsR family transcriptional regulator FOC06_10320 ENOG4105FDT acyl-CoA dehydrogenase FOC06_10335 ENOG4105DWD nucleoside recognition domain protein FOC06_10365 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC06_10425 ENOG4105E2A Dehydrogenase FOC06_10440 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_10445 ENOG4105HDK L-asparaginase FOC06_10450 ENOG4108IMY Transcriptional regulator FOC06_10460 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC06_10465 ENOG4105CUB amino acid FOC06_10475 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_10485 ENOG4105C6K Malic enzyme FOC06_10520 ENOG4105CSV Glutaminase FOC06_10555 ENOG4105CGH 5'-nucleotidase FOC06_10560 ENOG4105CH6 catalase FOC06_10570 ENOG4105CHJ isochorismatase hydrolase FOC06_10595 ENOG41090MY MarR family Transcriptional regulator FOC06_10630 ENOG4108606 TspO/MBR family FOC06_10635 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC06_10650 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC06_10655 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC06_10670 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC06_10675 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC06_10680 ENOG4105DSE periplasmic solute binding protein FOC06_10685 ENOG4105CC5 ABC transporter FOC06_10690 ENOG4105DIK (ABC) transporter FOC06_10720 ENOG4105D6J arsenicaL-resistance protein FOC06_10725 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_10730 ENOG41085FC arsR family transcriptional regulator FOC06_10745 ENOG4105F7F Chaperone FOC06_10755 ENOG4105CHR reductase FOC06_10760 ENOG4108YXU transcriptional regulator AsnC family FOC06_10835 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC06_10840 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_10850 ENOG4105IIP Membrane FOC06_10865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_10870 ENOG41062D9 Histidine kinase FOC06_10895 ENOG4105K6H D-cysteine desulfhydrase FOC06_10915 ENOG4105VZ8 Transcriptional regulator FOC06_10930 ENOG4108NNI Beta-lactamase domain-containing protein FOC06_10935 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC06_10945 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC06_10950 ENOG4105JQZ Methyltransferase FOC06_10965 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC06_10970 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC06_10985 ENOG4105BZU Histidine kinase FOC06_11000 ENOG4108U05 Transcriptional regulator FOC06_11015 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC06_11020 ENOG4105DJB Major Facilitator Superfamily FOC06_11025 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC06_11030 ENOG4107QR9 Iron-sulfur cluster binding protein FOC06_11040 ENOG4106P55 Transcriptional regulator FOC06_11050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC06_11085 ENOG4105TRI Hydrolase FOC06_11115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC06_11145 ENOG4107QJQ Mate efflux family protein FOC06_11165 ENOG4105EQ0 Major Facilitator superfamily FOC06_11170 ENOG4108JGH Tetr family transcriptional regulator FOC06_11185 ENOG4105C44 Serine transporter FOC06_11190 ENOG4105EJQ L-serine dehydratase FOC06_11205 ENOG4108JPW Aminotransferase FOC06_11220 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC06_11230 ENOG4105DVH amino acid FOC06_11245 ENOG4108JQ1 Dehydrogenase FOC06_11265 ENOG4108AEY RNA polymerase sigma factor FOC06_11280 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC06_11285 ENOG410874W AraC family transcriptional regulator FOC06_11335 ENOG4108ISG Major Facilitator FOC06_11345 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC06_11350 ENOG4105CZM Major Facilitator FOC06_11370 ENOG4105DA5 (ABC) transporter FOC06_11375 ENOG41069JR FOC06_11385 ENOG4105RXJ FOC06_11390 ENOG4105KPY Small multidrug resistance protein FOC06_11395 ENOG4105KBX Transcriptional regulator, TetR family FOC06_11405 ENOG4105CRW Short chain fatty acid transporter FOC06_11415 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC06_11445 ENOG4108JJB ABC transporter FOC06_11450 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC06_11475 ENOG4108K8S endonuclease I FOC06_11490 ENOG41067QW Transcriptional regulator FOC06_11500 ENOG4108Z66 YbaK ebsC protein FOC06_11505 ENOG4105CUT histidyl-tRNA synthetase FOC06_11520 ENOG4105KVH Transcriptional regulator FOC06_11525 ENOG4108RCM Nitroreductase FOC06_11545 ENOG4108PSK reductase FOC06_11555 ENOG4105CJ1 ABC, transporter FOC06_11615 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_11620 ENOG4105DKQ ROK family FOC06_11625 ENOG4106UW1 Major Facilitator superfamily FOC06_11630 ENOG4108UW5 maltose o-acetyltransferase FOC06_11640 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC06_11645 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC06_11650 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC06_11670 ENOG4105DMQ Methyltransferase FOC06_11680 ENOG4105EV4 Multidrug resistance protein mdtH FOC06_11710 ENOG4105C37 (CBS) domain FOC06_11725 ENOG4105DDN Pentapeptide repeat-containing protein FOC06_11730 ENOG4105XDF Protein of unknown function (DUF1272) FOC06_11735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC06_11740 ENOG4105CMG Carbohydrate kinase FOC06_11745 ENOG4105C6Z Gluconate FOC06_11750 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC06_11765 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC06_11770 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC06_11775 ENOG4105CIS alcohol dehydrogenase FOC06_11780 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC06_11795 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC06_11800 ENOG4105D4Y metalloprotease FOC06_11820 ENOG4105CV8 reductase FOC06_11825 ENOG4105F27 Major Facilitator FOC06_11840 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC06_11845 ENOG4105C44 Serine transporter FOC06_11875 ENOG4105KVH Transcriptional regulator FOC06_11880 ENOG4108TZY GntR Family Transcriptional Regulator FOC06_11890 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC06_11895 ENOG4105KVH Transcriptional regulator FOC06_11900 ENOG4105KVH Transcriptional regulator FOC06_11935 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC06_11945 ENOG4105CHR reductase FOC06_11965 ENOG4105KVH Transcriptional regulator FOC06_12035 ENOG4105KAF membrAne FOC06_12060 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC06_12075 ENOG4107YXZ hydrolase, family 25 FOC06_12100 ENOG4105ED2 Beta-lactamase FOC06_12110 ENOG4105H3G oxidoreductase FOC06_12180 ENOG4108TN2 lmbE family FOC06_12190 ENOG4107R3E Citrate transporter FOC06_12210 ENOG4108MES Periplasmic binding protein FOC06_12215 ENOG4105EHG Permease protein FOC06_12220 ENOG4105DQ5 transport system permease protein FOC06_12225 ENOG4105NX3 Membrane FOC06_12230 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC06_12250 ENOG4107CUJ Protein of unknown function (DUF2690) FOC06_12260 ENOG4107V2S Transcriptional regulator FOC06_12280 ENOG4105C98 muts2 protein FOC06_12290 ENOG4105E5K Alpha-amylase FOC06_12300 ENOG4105DPN Oligoendopeptidase f FOC06_12305 ENOG4108A04 Beta-lactamase FOC06_12335 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC06_12360 ENOG41082BM Transcriptional regulator, arsr family FOC06_12365 ENOG4105CIS alcohol dehydrogenase FOC06_12390 ENOG4105RHY Pfam:UPF0157 FOC06_12400 ENOG4105C09 Bile acid FOC06_12405 ENOG4105CQB FAD linked oxidase domain protein FOC06_12425 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC06_12435 ENOG4105K64 Glycosyl transferase, family 2 FOC06_12440 ENOG4105E39 Enoyl-CoA hydratase FOC06_12450 ENOG4105KT7 mgtC SapB transporter FOC06_12465 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_12470 ENOG41073R8 VanW family FOC06_12480 ENOG4108R1P FOC06_12500 ENOG4105VEQ Cold shock protein FOC06_12520 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC06_12540 ENOG410904N short-chain dehydrogenase reductase FOC06_12550 ENOG4106IQC argininosuccinate lyase FOC06_12565 ENOG4108IA2 Sodium pantothenate symporter FOC06_12575 ENOG4105C26 Dehydrogenase FOC06_12580 ENOG4105CHR reductase FOC06_12590 ENOG4105EWU Squalene--hopene cyclase FOC06_12600 ENOG4105FR1 rard protein FOC06_12605 ENOG410696E Membrane FOC06_12620 ENOG4105D1F ATP-binding protein FOC06_12630 ENOG4108ZAF Molybdopterin FOC06_12635 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_12640 ENOG4105D06 uba thif-type nad fad binding protein FOC06_12645 ENOG4105TMB Formate nitrite transporter FOC06_12655 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC06_12660 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC06_12670 ENOG4108JB9 formate dehydrogenase FOC06_12675 ENOG4105E1K spore germination protein FOC06_12740 ENOG4108KGH TRANSCRIPTIONal FOC06_12750 ENOG4105EMN RNA polymerase sigma factor FOC06_12765 ENOG4105CIG ABC transporter FOC06_12775 ENOG4105D9R oxidoreductase FOC06_12785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC06_12790 ENOG4105K4P CoA-binding domain protein FOC06_12795 ENOG4105C0H protease FOC06_12800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_12810 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC06_12815 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC06_12820 ENOG4105W8X HesB YadR YfhF-family protein FOC06_12850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC06_12855 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC06_12865 ENOG4108JJA ABC, transporter FOC06_12870 ENOG4108I0Z Aconitate hydratase FOC06_12910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_12930 ENOG4107F3J Amp-dependent synthetase and ligase FOC06_12935 ENOG4107ZYJ bioY protein FOC06_12940 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_12990 ENOG4107AYK membrAne FOC06_13000 ENOG4105BZU Histidine kinase FOC06_13005 ENOG4105FBA Phospholipase Carboxylesterase FOC06_13010 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC06_13015 ENOG4105CK7 Sodium proline symporter FOC06_13020 ENOG4105CBC glutamate synthase FOC06_13025 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC06_13030 ENOG4108VJ1 Transcriptional regulator (CarD family FOC06_13035 ENOG4108903 Formimidoylglutamase FOC06_13060 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC06_13120 ENOG4107QIV Cytochrome c biogenesis protein FOC06_13130 ENOG4107RSM transcriptional regulator FOC06_13135 ENOG4105VAW lrga family FOC06_13140 ENOG41067MG lrgb family FOC06_13165 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC06_13180 ENOG4105BZ1 (ABC) transporter FOC06_13185 ENOG4105BZ1 (ABC) transporter FOC06_13205 ENOG4105D7V transposase FOC06_13220 ENOG4105D5T phosphonate abc transporter FOC06_13240 ENOG4108SVB resolvase FOC06_13260 ENOG4105K7K Transcriptional regulator FOC06_13290 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC06_13295 ENOG4105XSJ toxin secretion phage lysis holin FOC06_13480 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC06_13580 ENOG4105C5F glutamine synthetase FOC06_13585 ENOG4105KV4 Transcriptional regulator FOC06_13590 ENOG4105CXI aluminum resistance protein FOC06_13600 ENOG4105EN6 Membrane FOC06_13610 ENOG4106F1P AAA ATPase, central domain protein FOC06_13640 ENOG41069ER domain protein FOC06_13645 ENOG4105DM4 PTS System FOC06_13650 ENOG4105DE4 1-phosphofructokinase FOC06_13655 ENOG4105E98 transcriptional regulator DeoR family FOC06_13665 ENOG4108SJC Membrane FOC06_13675 ENOG4105C85 amino acid FOC06_13690 ENOG4105TMB Formate nitrite transporter FOC06_13695 ENOG4105K70 DNA-binding protein FOC06_13700 ENOG4105C59 p-type ATPase FOC06_13705 ENOG410681U heavy metal transport detoxification protein FOC06_13710 ENOG4105VPX protein, conserved in bacteria FOC06_13720 ENOG4105NIV Esterase FOC06_13725 ENOG4105E0A ABC, transporter FOC06_13745 ENOG4105CGK Exodeoxyribonuclease III FOC06_13755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC06_13760 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC06_13790 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_13795 ENOG4105BZU Histidine kinase FOC06_13815 ENOG41067MG lrgb family FOC06_13830 ENOG4107TTQ Alpha beta hydrolase fold FOC06_13835 ENOG4107YEI lmbE family FOC06_13860 ENOG4105F0V Cell wall hydrolase FOC06_13865 ENOG4107R6R udp-galactopyranose mutase FOC06_13870 ENOG4105E0M Sulfatase FOC06_13875 ENOG410890F Dynamin family FOC06_13885 ENOG4107QHE Choloylglycine hydrolase FOC06_13910 ENOG4105DA5 (ABC) transporter FOC06_13935 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC06_13940 ENOG4105DQU oxidoreductase, subunit beta FOC06_13945 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC06_13950 ENOG4108IGT Dipeptidase FOC06_13955 ENOG4105MCT stage V sporulation protein S FOC06_13960 ENOG4105D48 metallophosphoesterase FOC06_13985 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC06_14000 ENOG4105XZV Protein of unknown function (DUF3243) FOC06_14005 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC06_14030 ENOG4108JQ9 ABC transporter FOC06_14035 ENOG4105DIH basic membrane FOC06_14040 ENOG4105FDP GntR family transcriptional regulator FOC06_14045 ENOG4107QZI cell division protein FtsK FOC06_14055 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC06_14065 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC06_14075 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC06_14080 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC06_14085 ENOG4105E35 Dipicolinate synthase subunit A FOC06_14095 ENOG4105C1V Peptidase, M16 FOC06_14115 ENOG4105DTN riboflavin biosynthesis protein ribF FOC06_14120 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC06_14130 ENOG4105W7A Protein of unknown function (DUF503) FOC06_14140 ENOG4105VHM ribosomal protein FOC06_14145 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC06_14150 ENOG4105CHV Transcription elongation factor NusA FOC06_14160 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC06_14170 ENOG4105DZP Membrane-associated zinc metalloprotease FOC06_14175 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC06_14180 ENOG4105KNE Phosphatidate cytidylyltransferase FOC06_14185 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC06_14225 ENOG4108HE4 integrase family FOC06_14235 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC06_14245 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC06_14260 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC06_14285 ENOG4105VB6 UPF0109 protein FOC06_14305 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC06_14310 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC06_14325 ENOG4105CHR reductase FOC06_14330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC06_14345 ENOG4105CB5 ATP-dependent DNA helicase recG FOC06_14350 ENOG4105DP4 dak2 domain fusion protein ylov FOC06_14355 ENOG4108ZAA Alkaline-shock protein FOC06_14370 ENOG4105FJ0 thiamine FOC06_14375 ENOG4105DJV ribulose-phosphate 3-epimerase FOC06_14380 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC06_14385 ENOG4105D9P serine threonine protein kinase FOC06_14390 ENOG4108ZF3 Phosphatase FOC06_14400 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC06_14410 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC06_14415 ENOG4105C25 Primosomal protein n' FOC06_14420 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC06_14440 ENOG4105DSJ YicC domain protein FOC06_14450 ENOG4105F23 Fibronectin-binding protein FOC06_14455 ENOG4105DC7 peptidase M24 FOC06_14510 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC06_14535 ENOG4105C34 Pseudouridine synthase FOC06_14560 ENOG4105DBK s4 domain protein FOC06_14565 ENOG41067XK integral membrane protein FOC06_14575 ENOG4105DFA alanine racemase domain protein FOC06_14580 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC06_14585 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC06_14595 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_14605 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC06_14610 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC06_14615 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC06_14620 ENOG4105D4A Cell wall formation (By similarity) FOC06_14625 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC06_14630 ENOG4105CNI cell division protein FtsW FOC06_14645 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC06_14650 ENOG4105CJN penicillin-binding protein FOC06_14655 ENOG4105CJN penicillin-binding protein FOC06_14660 ENOG41068DC Essential cell division protein (By similarity) FOC06_14700 ENOG4105KNH Nucleic acid-binding protein FOC06_14750 ENOG4105XSJ toxin secretion phage lysis holin FOC06_14830 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC06_14840 ENOG4105CAR Terminase, large subunit FOC06_14925 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC06_14940 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_14985 ENOG4108IMY Transcriptional regulator FOC06_15005 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC06_15015 ENOG41063PX domain protein FOC06_15020 ENOG4105D78 K07001 NTE family protein FOC06_15025 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC06_15035 ENOG4106H78 methyltransferase FOC06_15055 ENOG4107TB6 phosphoglycerate mutase FOC06_15070 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC06_15120 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC06_15140 ENOG4108IAB Phoh family FOC06_15160 ENOG4105QA2 FOC06_15165 ENOG4105CI3 gtp-binding protein typa FOC06_15175 ENOG4105ECY inositol monophosphatase FOC06_15195 ENOG4105CXN decarboxylase FOC06_15240 ENOG4105C7S Dehydrogenase FOC06_15245 ENOG4105CPP Dehydrogenase, E1 component FOC06_15260 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC06_15275 ENOG4105CN5 Metallo-Beta-Lactamase FOC06_15280 ENOG4107ZYR domain protein FOC06_15315 ENOG4108XRC Protein of unknown function (DUF458) FOC06_15320 ENOG4107IN1 Protein of unknown function (DUF1797) FOC06_15335 ENOG4105EPM Diguanylate phosphodiesterase FOC06_15340 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC06_15355 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC06_15365 ENOG4105UIN FOC06_15420 ENOG4108HGU Histidine kinase FOC06_15430 ENOG4105CHM Aminotransferase FOC06_15435 ENOG4105FKQ transcriptional regulator FOC06_15440 ENOG4105EG2 ABC transporter, permease FOC06_15450 ENOG4107FKK extracellular solute-binding protein family 1 FOC06_15460 ENOG4105CG3 alpha amylase, catalytic region FOC06_15505 ENOG4105CHU acetyl-coa acetyltransferase FOC06_15545 ENOG4105K7K Transcriptional regulator FOC06_15550 ENOG4105DTD Dehydrogenase FOC06_15560 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC06_15570 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC06_15595 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC06_15615 ENOG4106TD9 Diguanylate cyclase FOC06_15635 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC06_15650 ENOG4105CID antiterminator FOC06_15660 ENOG4105FDP GntR family transcriptional regulator FOC06_15670 ENOG4105CE4 GlcNAc 6-P deacetylase FOC06_15705 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC06_15710 ENOG4105PTM secreted protein FOC06_15715 ENOG4105J7I hydrolase FOC06_15725 ENOG4105G6R Stage v sporulation protein ae FOC06_15735 ENOG4105CZ3 stage V sporulation protein ad FOC06_15740 ENOG41090VF Stage v sporulation protein ac FOC06_15760 ENOG4105C8J )-transporter FOC06_15765 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_15775 ENOG41082AN stage II sporulation protein FOC06_15780 ENOG4105DZ1 carboxypeptidase FOC06_15785 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_15790 ENOG4105DVE abc transporter atp-binding protein FOC06_15820 ENOG4105D7N magnesium and cobalt transport protein CorA FOC06_15845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC06_15855 ENOG4105I3K Ferric uptake regulator, Fur family FOC06_15860 ENOG4105MZ9 stage II sporulation protein m FOC06_15880 ENOG4105CPC Aldo Keto reductase FOC06_15890 ENOG4105RHY Pfam:UPF0157 FOC06_15910 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC06_15920 ENOG4105ETE Transcriptional regulator (LacI family FOC06_15925 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC06_15945 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC06_15950 ENOG4108R6K riboflavin synthase, subunit alpha FOC06_15970 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC06_15975 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_15980 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_15985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC06_15995 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC06_16005 ENOG4105DFD Na H antiporter FOC06_16010 ENOG4105CGH 5'-nucleotidase FOC06_16050 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC06_16065 ENOG4108IXY short-chain dehydrogenase reductase FOC06_16075 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_16080 ENOG4105EJQ L-serine dehydratase FOC06_16100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC06_16110 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC06_16115 ENOG4105D9U N-acetyltransferase FOC06_16130 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC06_16135 ENOG4108QEG Membrane FOC06_16140 ENOG4105CDA abc transporter atp-binding protein FOC06_16145 ENOG4105E5Q amino acid AbC transporter FOC06_16150 ENOG4108HW3 (ABC) transporter FOC06_16160 ENOG4105G7B Protein of unknown function (DUF2992) FOC06_16175 ENOG4105C7S Dehydrogenase FOC06_16180 ENOG4105CPP Dehydrogenase, E1 component FOC06_16200 ENOG4107RDP Dehydrogenase FOC06_16210 ENOG4108JUB Transcriptional regulator FOC06_16220 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC06_16235 ENOG4107QQR Sporulation FOC06_16240 ENOG4105S1Z Stage IV sporulation protein B FOC06_16245 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC06_16255 ENOG4105DX0 Hemolysin A FOC06_16265 ENOG4105CTB Polyprenyl synthetase FOC06_16290 ENOG4108ZSR alkaline shock protein FOC06_16295 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC06_16320 ENOG410644B Stage III sporulation protein af FOC06_16330 ENOG4105KQ4 Stage iii sporulation protein ad FOC06_16335 ENOG4108CQH stage III sporulation protein AC FOC06_16340 ENOG4105KR5 Stage iii sporulation protein FOC06_16345 ENOG4105CD2 stage iii sporulation protein aa FOC06_16370 ENOG4105DC7 peptidase M24 FOC06_16385 ENOG4105CBJ Metal-dependent enzyme FOC06_16395 ENOG4107YBY Hydrolase FOC06_16415 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC06_16420 ENOG4105WZW rhodanese family FOC06_16440 ENOG41080TC multidrug resistance protein FOC06_16475 ENOG4105CJ1 ABC, transporter FOC06_16480 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC06_16510 ENOG4105C0D helicase FOC06_16630 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC06_16635 ENOG4105C3R Methionine synthase FOC06_16645 ENOG4105C28 cystathionine FOC06_16650 ENOG4105C28 cystathionine FOC06_16670 ENOG4105C5X domain protein FOC06_16680 ENOG4105DKQ ROK family FOC06_16690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC06_16705 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC06_16710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC06_16715 ENOG4105E2Z phosphate ABC transporter (Permease FOC06_16720 ENOG4105C8U phosphate abc transporter FOC06_16725 ENOG4105PWN phosphate abc transporter FOC06_16730 ENOG4107RF6 penicillin-binding protein FOC06_16740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_16765 ENOG4105N80 Ferric uptake regulator, Fur family FOC06_16775 ENOG4105FDK ABC transporter FOC06_16780 ENOG4108JYZ YitT family FOC06_16785 ENOG41069ZM Protein of unknown function (DUF2624) FOC06_16810 ENOG4105EGD dinuclear metal center protein, YbgI family FOC06_16825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_16830 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC06_16860 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC06_16865 ENOG4105KG3 cytidine deaminase FOC06_16870 ENOG4107YR5 Diacylglycerol kinase FOC06_16880 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC06_16885 ENOG4105C9A Phoh family FOC06_16895 ENOG41068P3 sporulation protein YqfC FOC06_16900 ENOG4105KTH gatB Yqey FOC06_16910 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC06_16915 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC06_16935 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC06_16945 ENOG4105CSA Coproporphyrinogen iii oxidase FOC06_16950 ENOG4105KVH Transcriptional regulator FOC06_16975 ENOG4105TQK DNA polymerase iii, delta' subunit FOC06_16985 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC06_16990 ENOG4108UK2 deaminase FOC06_16995 ENOG4105KQC Competence protein FOC06_17005 ENOG4105DXX methyltransferase FOC06_17015 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC06_17025 ENOG410812S Rna-binding protein FOC06_17035 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC06_17040 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC06_17055 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_17075 ENOG4108TVJ Nitroreductase FOC06_17090 ENOG4105G6Z alkaline phosphatase FOC06_17100 ENOG4108MUZ hydrolase FOC06_17135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC06_17140 ENOG4105MIR Phenylalanine 4-monooxygenase FOC06_17190 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC06_17195 ENOG4108V5C ABC transporter FOC06_17205 ENOG4108EKI Dehydrogenase FOC06_17210 ENOG4105C28 cystathionine FOC06_17240 ENOG4107XRG penicillin-binding protein FOC06_17255 ENOG4105CFP Peptidase U32 FOC06_17260 ENOG4105XYU peptidase (U32 family) FOC06_17265 ENOG4108VQJ O-methyltransferase FOC06_17270 ENOG4105HHA aminodeoxychorismate lyase FOC06_17290 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC06_17300 ENOG4105C02 permease FOC06_17315 ENOG41060CR FOC06_17320 ENOG4105C7H Helicase, RecD TraA family FOC06_17330 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC06_17335 ENOG4105C3J Cysteine desulfurase FOC06_17345 ENOG4105D1H recombination factor protein RarA FOC06_17350 ENOG4108VCI transcription factor, rsfa family FOC06_17355 ENOG4105CUZ uba thif-type nad fad binding protein FOC06_17365 ENOG4105CUT histidyl-tRNA synthetase FOC06_17375 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC06_17385 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC06_17390 ENOG41076HS cation diffusion facilitator family transporter FOC06_17395 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC06_17405 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC06_17410 ENOG4108QG2 Membrane FOC06_17420 ENOG4105VIE preprotein translocase, subunit YajC FOC06_17435 ENOG41061AI Protein of unknown function (DUF2905) FOC06_17450 ENOG4108HUF Transporter FOC06_17460 ENOG4108IPJ Membrane FOC06_17465 ENOG4108IPJ Membrane FOC06_17470 ENOG41082BM Transcriptional regulator, arsr family FOC06_17495 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC06_17500 ENOG4108IYU L-aspartate oxidase FOC06_17515 ENOG4108RPX mosc domain containing protein FOC06_17520 ENOG4105CQC Prephenate dehydratase FOC06_17550 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC06_17565 ENOG4105X36 (ribosomal) protein FOC06_17575 ENOG4105C03 ribonuclease FOC06_17590 ENOG4107QMS site-determining protein FOC06_17605 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC06_17610 ENOG4105DFF Rod shape-determining protein mreb FOC06_17630 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC06_17635 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC06_17645 ENOG41068KH stage VI sporulation protein D FOC06_17655 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC06_17680 ENOG4105K56 Transcriptional regulator FOC06_17700 ENOG4108IUQ atp-dependent protease FOC06_17725 ENOG4108QCI YvbH-like oligomerisation region FOC06_17745 ENOG4105M59 Phosphodiesterase, mj0936 family FOC06_17750 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC06_17760 ENOG4108XJQ germination protein FOC06_17770 ENOG4108PCX Major Facilitator FOC06_17780 ENOG4105KBX Transcriptional regulator, TetR family FOC06_17795 ENOG4105PFC Transcriptional regulator FOC06_17810 ENOG4105DZC cytosine deaminase FOC06_17815 ENOG4105DZC cytosine deaminase FOC06_17820 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC06_17825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_17840 ENOG4108JQ7 (ABC) transporter FOC06_17850 ENOG4105DY9 regulatoR FOC06_17865 ENOG41067S9 phage shock protein C, PspC FOC06_17870 ENOG4108JCI Transcriptional regulator FOC06_17880 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC06_17885 ENOG4108Z40 Transcriptional regulator FOC06_17890 ENOG4105RHA ABC transporter, permease FOC06_17895 ENOG4108IUX (ABC) transporter FOC06_17900 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC06_17910 ENOG4105E14 MotA TolQ exbB proton channel FOC06_17915 ENOG4108VXD carboxy-peptidase FOC06_17925 ENOG4105E33 succinate dehydrogenase FOC06_17935 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC06_17950 ENOG4105K63 Thioredoxin FOC06_17955 ENOG4105C10 Electron transfer flavoprotein FOC06_17960 ENOG4105BZJ Electron transfer flavoprotein FOC06_17965 ENOG41060WC Enoyl-CoA hydratase FOC06_17970 ENOG4107Z3H Transcriptional regulator, TetR family FOC06_17975 ENOG4105CEY Amp-dependent synthetase and ligase FOC06_17985 ENOG4105J76 Periplasmic binding protein FOC06_17990 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC06_18030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_18040 ENOG4105DR4 Methyltransferase FOC06_18055 ENOG4105KFN sortase, SrtB family FOC06_18060 ENOG4105E0A ABC, transporter FOC06_18075 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC06_18085 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC06_18095 ENOG4105FE9 pseudouridine synthase FOC06_18105 ENOG4105DCG PHP domain protein FOC06_18140 ENOG4105C5S asparaginyl-tRNA synthetase FOC06_18145 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC06_18155 ENOG4108RWN rrna methyltransferase FOC06_18190 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC06_18195 ENOG4105CW7 secretion protein, HlyD family FOC06_18200 ENOG4108JGH Tetr family transcriptional regulator FOC06_18205 ENOG4105CN9 Peptidase m42 family protein FOC06_18225 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC06_18230 ENOG4105C22 threonyL-tRNA synthetase FOC06_18235 ENOG4108TDW sporulation protein YtxC FOC06_18255 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC06_18265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC06_18270 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC06_18280 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC06_18285 ENOG4105C2M dna polymerase I FOC06_18290 ENOG4105BZU Histidine kinase FOC06_18295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_18310 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC06_18315 ENOG4105BZN citrate synthase FOC06_18325 ENOG4108REF Sporulation integral membrane protein ytvi FOC06_18330 ENOG4105FS0 cytoplasmic membrane protein FOC06_18355 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC06_18360 ENOG4105C6K Malic enzyme FOC06_18365 ENOG4105C0B DNA polymerase III (alpha subunit) FOC06_18370 ENOG4105VV2 FOC06_18380 ENOG4105SFS phosphoesterase RecJ domain protein FOC06_18410 ENOG4105DC7 peptidase M24 FOC06_18445 ENOG4105Z7P Acetyltransferase (GNAT) family FOC06_18450 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC06_18460 ENOG4105VZ8 Transcriptional regulator FOC06_18480 ENOG4107YZX Universal stress protein FOC06_18520 ENOG4108JYZ YitT family FOC06_18540 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC06_18550 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC06_18555 ENOG4105KBJ sporulation protein ytfj FOC06_18570 ENOG4105EFZ amidohydrolase FOC06_18580 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC06_18605 ENOG4106KR7 LysR family Transcriptional regulator FOC06_18625 ENOG4105C28 cystathionine FOC06_18645 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC06_18655 ENOG4105EMN RNA polymerase sigma factor FOC06_18675 ENOG4105F1V Acetoin utilization protein FOC06_18680 ENOG4105W87 Cbs domain FOC06_18685 ENOG4105DGU Histone deacetylase FOC06_18695 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_18705 ENOG4107SNB ankyrin repeat protein YahD FOC06_18710 ENOG4105EP9 oxidoreductase FOC06_18740 ENOG4105ETE Transcriptional regulator (LacI family FOC06_18760 ENOG4105C88 aminopeptidase FOC06_18805 ENOG4108VDD TRNA binding domain protein FOC06_18835 ENOG4105C8F Beta-lactamase domain protein FOC06_18850 ENOG4108V15 phosphotransferase enzyme family FOC06_18855 ENOG4108IUM Glycogen debranching enzyme FOC06_18870 ENOG4105YW5 deoR family transcriptional regulator FOC06_18885 ENOG4105CBX hi0933 family FOC06_18920 ENOG4108VJ1 Transcriptional regulator (CarD family FOC06_18925 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC06_18930 ENOG4105CSC Glucose uptake protein FOC06_18945 ENOG4108ZAF Molybdopterin FOC06_18950 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC06_18955 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC06_18965 ENOG4105D06 uba thif-type nad fad binding protein FOC06_18990 ENOG41085GJ domain protein FOC06_19000 ENOG4105DWV Homoserine O-trans-acetylase FOC06_19010 ENOG4108B31 Spore germination protein FOC06_19045 ENOG410605W Major Facilitator FOC06_19050 ENOG4107S91 Sodium hydrogen exchanger FOC06_19055 ENOG4105NCW Trka-c domain protein FOC06_19070 ENOG4105C19 ABC transporter FOC06_19090 ENOG4105N5T Radical SAM Protein FOC06_19100 ENOG4105DA5 (ABC) transporter FOC06_19130 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC06_19135 ENOG4108Z0R Transferase FOC06_19140 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC06_19145 ENOG4105BZF Glycosyl transferase (Group 1 FOC06_19155 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC06_19210 ENOG4105EGD dinuclear metal center protein, YbgI family FOC06_19215 ENOG4105BZU Histidine kinase FOC06_19220 ENOG4105BZU Histidine kinase FOC06_19225 ENOG4107S9D Alpha beta hydrolase FOC06_19245 ENOG4105D2X ABC transporter substrate-binding protein FOC06_19255 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC06_19310 ENOG4108V2W Carbonate dehydratase FOC06_19315 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC06_19320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC06_19365 ENOG41087YS Phage shock protein A FOC06_19400 ENOG4105BZU Histidine kinase FOC06_19405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_19430 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC06_19435 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC06_19470 ENOG4107ZTW SNARE associated Golgi FOC06_19485 ENOG4105C19 ABC transporter FOC06_19490 ENOG41086D8 Transcriptional regulator FOC06_19530 ENOG4105C6Z Gluconate FOC06_19535 ENOG4105FDP GntR family transcriptional regulator FOC06_19555 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC06_19585 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_19595 ENOG4108IPT Naphthoate synthase FOC06_19600 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC06_19605 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC06_19610 ENOG4105E4F Isochorismate synthase FOC06_19615 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC06_19625 ENOG4105VEQ Cold shock protein FOC06_19645 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC06_19655 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC06_19675 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_19770 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC06_19805 ENOG4105KT7 mgtC SapB transporter FOC06_19810 ENOG4107PBV potassium channel FOC06_19820 ENOG4107QYV phosphohexose isomerase FOC06_19825 ENOG4105WG9 Conserved Protein FOC06_19835 ENOG4105CHM Aminotransferase FOC06_19840 ENOG4108ZB6 transcriptional regulator AsnC family FOC06_19845 ENOG4105C5I Dehydrogenase FOC06_19850 ENOG4108MUZ hydrolase FOC06_19860 ENOG4105C87 Aminotransferase class I and II FOC06_19870 ENOG4105Y38 Kinase-associated protein B FOC06_19880 ENOG4107R3E Citrate transporter FOC06_19895 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC06_19900 ENOG4105KA0 thioesterase Superfamily protein FOC06_19920 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC06_19940 ENOG41069ER domain protein FOC06_19955 ENOG4105CEP NADH dehydrogenase FOC06_19985 ENOG4105EWC Purine nucleoside phosphorylase FOC06_20005 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC06_20030 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_20035 ENOG4105C4B ABC transporter, permease FOC06_20040 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC06_20085 ENOG41083MR nifu domain-containing protein FOC06_20100 ENOG4108W5N phosphatidylglycerophosphatase a FOC06_20110 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC06_20115 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC06_20130 ENOG4105CBT Fructose-1,6-bisphosphatase FOC06_20145 ENOG4105MMD transcriptional regulator FOC06_20150 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC06_20155 ENOG4107TXC Transcriptional regulator FOC06_20160 ENOG41090T1 Membrane FOC06_20185 ENOG4105FAA peptidase M23 FOC06_20195 ENOG4105KZD Domain of unknown function (DUF1805) FOC06_20200 ENOG4107R8B 5'-nucleotidase FOC06_20220 ENOG4105DIW FeS assembly protein SUFB FOC06_20225 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC06_20230 ENOG4105C9B Cysteine desulfurase FOC06_20235 ENOG4105JRK feS assembly protein SufD FOC06_20240 ENOG4105C3K feS assembly ATPase SufC FOC06_20245 ENOG4105D01 (LipO)protein FOC06_20250 ENOG4105D01 (LipO)protein FOC06_20255 ENOG4108UMI ABC transporter, permease FOC06_20290 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC06_20335 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC06_20360 ENOG4108W8B Beta-lactamase domain protein FOC06_20365 ENOG4105C1G acyl-Coa dehydrogenase FOC06_20370 ENOG4105CHU acetyl-coa acetyltransferase FOC06_20385 ENOG4105DZ1 carboxypeptidase FOC06_20405 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC06_20420 ENOG4108SUT Major Facilitator Superfamily FOC06_20425 ENOG4107R7I amino acid FOC06_20435 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC06_20445 ENOG4107AYK membrAne FOC06_20480 ENOG4107ZTW SNARE associated Golgi FOC06_20490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC06_20495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_20500 ENOG4105BZU Histidine kinase FOC06_20510 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC06_20525 ENOG4105VG1 fes assembly suf system protein FOC06_20530 ENOG4105D4Y metalloprotease FOC06_20550 ENOG4107S91 Sodium hydrogen exchanger FOC06_20555 ENOG4105NCW Trka-c domain protein FOC06_20565 ENOG4108RMU ferritin dps family protein FOC06_20580 ENOG4108URH decarboxylase FOC06_20600 ENOG4105D9N nucleoside FOC06_20605 ENOG4105D9N nucleoside FOC06_20620 ENOG4108RYK Nad-dependent epimerase dehydratase FOC06_20635 ENOG4105CV8 reductase FOC06_20640 ENOG4105F27 Major Facilitator FOC06_20645 ENOG4105KVH Transcriptional regulator FOC06_20660 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC06_20665 ENOG4105D4A Cell wall formation (By similarity) FOC06_20675 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_20685 ENOG4105WMR Protein CrcB homolog FOC06_20690 ENOG4105WMR Protein CrcB homolog FOC06_20705 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC06_20710 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC06_20725 ENOG4108IPW abc transporter atp-binding protein FOC06_20730 ENOG4105CM4 permease protein FOC06_20760 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC06_20770 ENOG4105XZU Preprotein translocase, subunit SecG FOC06_20775 ENOG41067MG lrgb family FOC06_20870 ENOG4105EFC phage portal protein HK97 family FOC06_20895 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC06_20905 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC06_20910 ENOG4105CP7 Triose-phosphate isomerase FOC06_20935 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_20955 ENOG41090VF Stage v sporulation protein ac FOC06_20960 ENOG4105CZ3 stage V sporulation protein ad FOC06_20975 ENOG4105H67 Protein of unknown function (DUF421) FOC06_20980 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC06_20985 ENOG4105KRI phosphocarrier protein (HPr FOC06_20995 ENOG4105CHW UPF0052 protein FOC06_21005 ENOG4108Z4K mutator MutT protein FOC06_21015 ENOG4105C3M thioredoxin reductase FOC06_21025 ENOG4108S4C acetyltransferase FOC06_21045 ENOG41086DT Membrane protein of unknown function FOC06_21055 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC06_21060 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC06_21065 ENOG4105D7V transposase FOC06_21080 ENOG4107TXC Transcriptional regulator FOC06_21105 ENOG4105HMI Membrane FOC06_21110 ENOG4105DUM transcriptional regulator, lysR family FOC06_21120 ENOG4108WS4 fmn reductase FOC06_21135 ENOG4105BZ1 (ABC) transporter FOC06_21145 ENOG4105CN1 protease FOC06_21150 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC06_21155 ENOG4105CAK Cell division ATP-binding protein ftsE FOC06_21175 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC06_21180 ENOG4105MS2 ribosomal subunit Interface protein FOC06_21185 ENOG4105VEQ Cold shock protein FOC06_21190 ENOG41081UC Inherit from COG: Competence protein FOC06_21205 ENOG4105KVH Transcriptional regulator FOC06_21215 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC06_21220 ENOG4108KGH TRANSCRIPTIONal FOC06_21225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC06_21230 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC06_21235 ENOG4105ESV Glycosyl transferase, family 4 FOC06_21245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC06_21260 ENOG410901P UPF0249 protein FOC06_21265 ENOG4105F8D glycoside hydrolase family 4 FOC06_21270 ENOG4105VCP PTS System FOC06_21275 ENOG4105CK1 PTS System FOC06_21285 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC06_21290 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC06_21295 ENOG4105VCP PTS System FOC06_21305 ENOG4105VZJ PTS System FOC06_21320 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC06_21325 ENOG4105ECB domain protein FOC06_21330 ENOG4107RSM transcriptional regulator FOC06_21370 ENOG4105DAA L-lactate FOC06_21380 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC06_21390 ENOG4105E0M Sulfatase FOC06_21420 ENOG4105C94 Transporter FOC06_21425 ENOG41069ER domain protein FOC06_21450 ENOG4105KBK Zinc finger, swim domain protein FOC06_21455 ENOG4105C0D helicase FOC06_21485 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC06_21495 ENOG4107RBB ABC transporter, permease FOC06_21500 ENOG4105C19 ABC transporter FOC06_21520 ENOG4105CXY transporter FOC06_21535 ENOG4105BZU Histidine kinase FOC06_21540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_21545 ENOG4105CMR udp-glucose 4-epimerase FOC06_21560 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC06_21565 ENOG4105EY8 ABC transporter FOC06_21620 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC06_21635 ENOG4105FRN stage II sporulation protein FOC06_21670 ENOG4106778 Protein of unknown function (DUF1146) FOC06_21675 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC06_21680 ENOG4105C8S subunit m FOC06_21685 ENOG4105D65 subunit l FOC06_21710 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC06_21715 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC06_21725 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC06_21730 ENOG4105BZU Histidine kinase FOC06_21780 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC06_21785 ENOG41062M3 atp synthase FOC06_21815 ENOG4108YZG isomerase FOC06_21830 ENOG4108VGI doxx family FOC06_21835 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC06_21850 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC06_21860 ENOG4108ZXQ stage ii sporulation protein r FOC06_21865 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC06_21870 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC06_21885 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC06_21890 ENOG4105CBT Fructose-1,6-bisphosphatase FOC06_21895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC06_21930 ENOG4105C1G acyl-Coa dehydrogenase FOC06_21935 ENOG4105C1G acyl-Coa dehydrogenase FOC06_21940 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC06_21950 ENOG4105DF6 Fe-S oxidoreductase FOC06_21965 ENOG4105BZU Histidine kinase FOC06_21990 ENOG4105BZU Histidine kinase FOC06_21995 ENOG4105KCT ABC transporter FOC06_22000 ENOG4108M15 ABC transporter FOC06_22005 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_22015 ENOG4105IIU Aminopeptidase FOC06_22035 ENOG4105EMN RNA polymerase sigma factor FOC06_22045 ENOG410684U Domain of unknown function (DUF1934) FOC06_22065 ENOG4105CYW agmatinase FOC06_22075 ENOG4105DXB Major Facilitator superfamily FOC06_22080 ENOG4107SWG transcriptional regulator MERR family FOC06_22085 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC06_22090 ENOG4105BZ4 penicillin-binding protein FOC06_22095 ENOG4108XFG YwhD family FOC06_22100 ENOG4108Z4T Peptidase M50 FOC06_22105 ENOG41069HH 4-oxalocrotonate tautomerase FOC06_22110 ENOG4105DCI Phosphohydrolase FOC06_22115 ENOG4108MES Periplasmic binding protein FOC06_22120 ENOG4105E0A ABC, transporter FOC06_22125 ENOG4105EHG Permease protein FOC06_22140 ENOG4108VCI transcription factor, rsfa family FOC06_22155 ENOG4108IJ2 phosphate acetyltransferase FOC06_22170 ENOG4108VKI Cell wall hydrolase FOC06_22200 ENOG410667J hydrolase FOC06_22205 ENOG4105VCH membrane FOC06_22215 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC06_22220 ENOG4105CJ1 ABC, transporter FOC06_22225 ENOG41090WU lipolytic protein G-D-S-L family FOC06_22240 ENOG4105D6E homoserine dehydrogenase FOC06_22265 ENOG4108Y4K DNA-binding transcriptional activator FOC06_22275 ENOG4105WH1 Two component transcriptional regulator luxr family FOC06_22285 ENOG4105DWF phosphomethylpyrimidine kinase FOC06_22290 ENOG4105BZU Histidine kinase FOC06_22295 ENOG4105VCD cytoplasmic protein FOC06_22300 ENOG4105D22 carbon starvation protein FOC06_22305 ENOG4105DY9 regulatoR FOC06_22310 ENOG41079KZ Major Facilitator Superfamily FOC06_22330 ENOG4105EN6 Membrane FOC06_22335 ENOG4106YBV Methyl-accepting chemotaxis FOC06_22345 ENOG4108S4H thioesterase Superfamily protein FOC06_22355 ENOG4105JEU Glycosyl transferase, family 2 FOC06_22360 ENOG4105C5H ABC transporter FOC06_22380 ENOG4105CKK Glycosyl transferase, family 2 FOC06_22385 ENOG41067SE Tetr family transcriptional regulator FOC06_22395 ENOG4105E0X reductase FOC06_22400 ENOG4106F5Q Membrane FOC06_22415 ENOG4105DY9 regulatoR FOC06_22420 ENOG4108HRK Histidine kinase FOC06_22425 ENOG4107RGD Major Facilitator superfamily FOC06_22440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC06_22450 ENOG4105IW1 AmiS UreI transporter FOC06_22460 ENOG4105CMR udp-glucose 4-epimerase FOC06_22465 ENOG4108UT2 hemolysin iii FOC06_22490 ENOG4105DPN Oligoendopeptidase f FOC06_22510 ENOG4105C0H protease FOC06_22515 ENOG4105Q2H domain protein FOC06_22530 ENOG4105BZU Histidine kinase FOC06_22535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_22565 ENOG4105CDU Replicative dna helicase FOC06_22575 ENOG4105BZR domain protein FOC06_22580 ENOG4108XMW Membrane FOC06_22590 ENOG4108UUM single-stranded DNA-binding protein FOC06_22600 ENOG4105C3G gtp-binding protein FOC06_22605 ENOG4105VDK protein, conserved in bacteria FOC06_22610 ENOG4105D8X mechanosensitive ion channel FOC06_22615 ENOG4108ZDA Sporulation protein YyaC FOC06_22620 ENOG4105FA0 parb-like partition protein FOC06_22625 ENOG4107QJE Chromosome Partitioning Protein FOC06_22645 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC06_22655 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC06_22675 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC06_22680 ENOG410848D S4 domain protein YaaA FOC06_22695 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC06_22730 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC06_22765 ENOG4105ZMH deoxynucleoside kinase FOC06_22775 ENOG4105GTG Isochorismatase FOC06_22780 ENOG4108Z6B deaminase FOC06_22790 ENOG4105C6E dna polymerase iii FOC06_22810 ENOG41067KS pro-sigma K processing FOC06_22845 ENOG4105CXN decarboxylase FOC06_22855 ENOG4105FA2 dna polymerase iii FOC06_22860 ENOG4105MA4 psp1 domain protein FOC06_22870 ENOG41060K3 Methyltransferase FOC06_22880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC06_22885 ENOG4105KRN Transcriptional regulator, abrb family FOC06_22895 ENOG4105F8V Hydrolase, tatD family FOC06_22900 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC06_22910 ENOG4105XFA sporulation peptidase YabG FOC06_22915 ENOG4105W42 Veg protein FOC06_22930 ENOG4105DFT pur operon repressor FOC06_22935 ENOG4105KME endoribonuclease L-psp FOC06_22950 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC06_22955 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC06_22965 ENOG4108JA2 transcriptioN-repair coupling factor FOC06_22970 ENOG4108M14 stage v sporulation protein t FOC06_22980 ENOG4108IY2 MazG family FOC06_22985 ENOG41082I2 s4 domain protein FOC06_22990 ENOG4105VYY sporulation protein yabp FOC06_23005 ENOG41060GV RNA binding s1 domain protein FOC06_23025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC06_23030 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC06_23035 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC06_23050 ENOG4105C6T cysteine synthase FOC06_23055 ENOG4105CRQ synthase (Component I) FOC06_23060 ENOG4105DDQ anthranilate synthase FOC06_23065 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC06_23070 ENOG4105EEI dihydropteroate synthase FOC06_23075 ENOG4105KRF dihydroneopterin aldolase FOC06_23080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC06_23090 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC06_23120 ENOG4108Z0C Uvrb UvrC protein FOC06_23135 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC06_23145 ENOG4105CTP PilT protein domain protein FOC06_23165 ENOG4105D7W serine acetyltransferase FOC06_23180 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC06_23185 ENOG4105M0M Tetracycline resistance protein FOC06_23190 ENOG4105QIV RNA polymerase FOC06_23205 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC06_23230 ENOG4107Y49 methyltransferase FOC06_23240 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC06_23245 ENOG4105XPM ribosomal protein FOC06_23350 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC06_23375 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC06_23385 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC06_23395 ENOG41067V7 50S ribosomal protein L36 FOC06_23425 ENOG4108JJB ABC transporter FOC06_23430 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC06_23435 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC06_23460 ENOG4105D1F ATP-binding protein FOC06_23475 ENOG4108NMV polysaccharide deacetylase FOC06_23555 ENOG4105C8B TIGR00159 family FOC06_23560 ENOG4107U5W ybbr family FOC06_23575 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC06_23580 ENOG4108VQT Alpha beta hydrolase fold protein FOC06_23600 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC06_23605 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC06_23640 ENOG4108UMI ABC transporter, permease FOC06_23645 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_23650 ENOG4105D01 (LipO)protein FOC06_23655 ENOG4105EE1 crotonyl-CoA reductase FOC06_23665 ENOG4105IQ5 FAD linked oxidase domain protein FOC06_23680 ENOG4105C2C drug resistance transporter, Bcr CflA FOC06_23695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_23700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_23705 ENOG4105C3U ABC transporter FOC06_23710 ENOG4108JQ7 (ABC) transporter FOC06_23740 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC06_23745 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC06_23755 ENOG4105II7 pyrroline-5-carboxylate reductase FOC06_23760 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC06_23770 ENOG4105E0C molybdate abc transporter FOC06_23780 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC06_23790 ENOG4105EGI Transcriptional regulator FOC06_23810 ENOG4105F6E Acyl-transferase FOC06_23830 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC06_23840 ENOG4108RE7 deoxyribonuclease FOC06_23845 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC06_23870 ENOG4105C5H ABC transporter FOC06_23885 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC06_23895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC06_23900 ENOG4105C3U ABC transporter FOC06_23905 ENOG4108JQ7 (ABC) transporter FOC06_23925 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC06_23930 ENOG4105ERH Fumarylacetoacetate hydrolase FOC06_23940 ENOG4108SC4 )-transporter FOC06_23950 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC06_23965 ENOG4107ZXI Rhomboid family FOC06_23975 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC06_23980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC06_23990 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC06_24090 ENOG4105K8N protein family UPF0079, ATPase FOC06_24095 ENOG41072GX Peptidase M22 Glycoprotease FOC06_24100 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC06_24105 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC06_24110 ENOG4105C5H ABC transporter FOC06_24125 ENOG4108TYN CAAX amino terminal protease family protein FOC06_24145 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_24155 ENOG4105BZU Histidine kinase FOC06_24185 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC06_24225 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_24245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC06_24265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC06_24270 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC06_24275 ENOG4105C83 adenylosuccinate lyase FOC06_24285 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC06_24310 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC06_24320 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC06_24345 ENOG4105C4R Atp-dependent dna helicase FOC06_24370 ENOG4108W2Y isochorismatase FOC06_24375 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC06_24380 ENOG4108UMI ABC transporter, permease FOC06_24385 ENOG4105D01 (LipO)protein FOC06_24405 ENOG410834F Transcriptional regulator FOC06_24430 ENOG4105CBD Diacylglycerol kinase FOC06_24435 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC06_24440 ENOG4108JPW Aminotransferase FOC06_24450 ENOG4105C26 Dehydrogenase FOC06_24455 ENOG4105KPY Small multidrug resistance protein FOC06_24475 ENOG4105D9N nucleoside FOC06_24480 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC06_24495 ENOG4108W15 Protein of unknown function (DUF1456) FOC06_24510 ENOG4105DTQ mandelate racemase muconate lactonizing FOC06_24520 ENOG4105DFD Na H antiporter FOC06_24540 ENOG4105D3R alkyl hydroperoxide reductase FOC06_24545 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC06_24555 ENOG4107W7X Aldolase FOC06_24560 ENOG4105EHG Permease protein FOC06_24565 ENOG4105DQ5 transport system permease protein FOC06_24570 ENOG4108V5C ABC transporter FOC06_24590 ENOG4106UIA FOC06_24595 ENOG4106UIA FOC06_24620 ENOG4105BZU Histidine kinase FOC06_24640 ENOG410756H nucleotidyltransferase FOC06_24645 ENOG4105D2S major facilitator superfamily FOC06_24660 ENOG4105E5Q amino acid AbC transporter FOC06_24665 ENOG4105EAB amino acid AbC transporter FOC06_24675 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_24680 ENOG4105C8Q Methyl-accepting chemotaxis FOC06_24690 ENOG4105CI1 PTS System FOC06_24720 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC06_24735 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC06_24750 ENOG4105C5H ABC transporter FOC06_24775 ENOG41062JF Transcriptional regulator FOC06_24795 ENOG4105DEU major facilitator superfamily FOC06_24810 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC06_24825 ENOG4108N0M stress protein FOC06_24830 ENOG4106FN3 tellurium resistance protein FOC06_24835 ENOG4106FN3 tellurium resistance protein FOC06_24840 ENOG4107TS3 membrane protein, TerC FOC06_24845 ENOG4108TTB tellurium resistance protein FOC06_24865 ENOG4105KJF protein tyrosine phosphatase FOC06_24875 ENOG4107U9T Pfam:Ribonuclease_BN FOC06_24880 ENOG4105C59 p-type ATPase FOC06_24885 ENOG4108IPJ Membrane FOC06_24905 ENOG4107ZTW SNARE associated Golgi FOC06_24920 ENOG410606W general stress protein FOC06_24925 ENOG4105UPD Calcium Proton FOC06_24965 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC06_24970 ENOG4105VTR Integrase FOC06_24975 ENOG4108IMY Transcriptional regulator FOC06_25235 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC06_25245 ENOG4108JUB Transcriptional regulator FOC06_25255 ENOG4108IQI permease FOC06_25280 ENOG4105CSV Glutaminase FOC06_25290 ENOG4108A04 Beta-lactamase FOC06_25305 ENOG4105CKK Glycosyl transferase, family 2 FOC06_25315 ENOG4107QQG Dehydrogenase FOC06_25320 ENOG4105C3I Nad-dependent epimerase dehydratase FOC06_25340 ENOG4105F1A Pyruvate formate-lyase FOC06_25360 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC06_25365 ENOG4105ECP epimerase FOC06_25395 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC06_25400 ENOG4105CEN a g-specific adenine glycosylase FOC06_25405 ENOG4106BXE FOC06_25425 ENOG4105BZ1 (ABC) transporter FOC06_25430 ENOG4107NBY Membrane FOC06_25435 ENOG4105CBC glutamate synthase FOC06_25445 ENOG4108IUW ABC transporter FOC06_25465 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC06_25470 ENOG4105G5W regulator Fur family FOC06_25585 ENOG4108JQC penicillin-binding protein 1A FOC06_25590 ENOG4107ZQN disulfide bond FOC06_25600 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC06_25610 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC06_25615 ENOG4105BZU Histidine kinase FOC06_25620 ENOG4105CYN Serine protein kinase FOC06_25640 ENOG4105C94 Transporter FOC06_25655 ENOG4105DZ6 Band 7 protein FOC06_25665 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC06_25675 ENOG4105D4T Citrate transporter FOC06_25695 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC06_25700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC06_25705 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC06_25710 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC06_25715 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC06_25720 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC06_25725 ENOG4108STX response regulator FOC06_25730 ENOG4105US7 Histidine kinase FOC06_25755 ENOG4108MRH transcriptional regulatory protein FOC06_25765 ENOG4105C6K Malic enzyme FOC06_25775 ENOG4108UZ3 Transporter FOC06_25780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC06_25790 ENOG4105BZU Histidine kinase FOC06_25795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC06_25800 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC06_25805 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC06_25810 ENOG4108JB9 formate dehydrogenase FOC06_25830 ENOG4105CUB amino acid FOC06_25840 ENOG4105C59 p-type ATPase FOC06_25845 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC06_25880 ENOG41073R8 VanW family FOC06_25885 ENOG4108KGH TRANSCRIPTIONal FOC06_25890 ENOG4105D9N nucleoside FOC06_25895 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC06_25900 ENOG4105C37 (CBS) domain FOC06_25905 ENOG4108IJ0 Aspartate ammonia-lyase FOC06_25910 ENOG4105DAA L-lactate FOC06_25925 ENOG4105DUX Transporter FOC06_25930 ENOG4108MES Periplasmic binding protein FOC06_25935 ENOG4105DQ5 transport system permease protein FOC06_25940 ENOG4108IHU transport system permease protein FOC06_25945 ENOG4105E0A ABC, transporter FOC06_25950 ENOG4105DMQ Methyltransferase FOC06_25960 ENOG4105EXW epimerase dehydratase FOC06_25970 ENOG4107T89 von Willebrand factor, type A FOC06_25975 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC06_25980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC06_25995 ENOG4105BZU Histidine kinase FOC06_26000 ENOG4105D5Q Arginine ornithine antiporter FOC06_26005 ENOG4107414 GntR family transcriptional regulator FOC06_26010 ENOG4105C5Y PTS System FOC06_26015 ENOG4105CG3 alpha amylase, catalytic region FOC06_26030 ENOG4105E1K spore germination protein FOC06_26040 ENOG4105CRN Aminoglycoside phosphotransferase FOC06_26045 ENOG4105BZG amino acid carrier protein FOC06_26050 ENOG4105CDA abc transporter atp-binding protein FOC06_26055 ENOG4105CT1 (ABC) transporter FOC06_26060 ENOG4105EAD ABC transporter FOC06_26065 ENOG4105DRP amino acid AbC transporter FOC06_26070 ENOG4108IQI permease FOC06_26095 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC06_26100 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC06_26105 ENOG4105BZU Histidine kinase FOC06_26120 ENOG4105CHH sulfate transporter FOC06_26125 ENOG41068KF Universal stress protein FOC06_26135 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC06_26145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC06_26150 ENOG4108JQ7 (ABC) transporter FOC06_26160 ENOG4105CXY transporter FOC06_26165 ENOG41067TZ transcriptional regulator, MarR family FOC06_26175 ENOG4105ETE Transcriptional regulator (LacI family FOC06_26180 ENOG4108RVA ribokinase FOC06_26195 ENOG4105CNN ABC, transporter FOC06_26200 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC06_26205 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC06_26265 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC06_26270 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC06_26275 ENOG41069ER domain protein FOC06_26280 ENOG4105VZ8 Transcriptional regulator FOC06_26285 ENOG4107D63 FOC06_26295 ENOG4105DUX Transporter FOC06_26315 ENOG4105C85 amino acid FOC06_26320 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_26360 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC06_26365 ENOG4105E2S oxidase) subunit II FOC06_26370 ENOG4108IQI permease FOC06_26385 ENOG4106CAD Protein of unknown function (DUF3311) FOC06_26390 ENOG4105E1V na solute symporter FOC06_26405 ENOG4108NHD germination protein FOC06_26410 ENOG4105CE1 Ferrous iron transport protein b FOC06_26415 ENOG4105CE1 Ferrous iron transport protein b FOC06_26420 ENOG4105CE1 Ferrous iron transport protein b FOC06_26425 ENOG4105CVA phosphate FOC06_26430 ENOG4105C8U phosphate abc transporter FOC06_26435 ENOG4105E2Z phosphate ABC transporter (Permease FOC06_26560 ENOG41080XQ Signal transduction protein with cbs domains FOC06_26580 ENOG4105ETU transcriptional activator (TenA FOC06_26590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC06_26600 ENOG4108VEU Thiamine monophosphate synthase FOC06_26605 ENOG41080HI glycine oxidase FOC06_26620 ENOG4105D06 uba thif-type nad fad binding protein FOC06_26625 ENOG4105DWF phosphomethylpyrimidine kinase FOC06_26675 ENOG4108INS Transcriptional regulator FOC06_26690 ENOG4105C7N Xanthine uracil vitamin C permease FOC06_26720 ENOG4105C5Y PTS System FOC06_26775 ENOG4107Y03 Nitroreductase FOC06_26780 ENOG4105ED1 spovr family FOC06_26805 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC06_26810 ENOG4105XTG Pfam:DUF156 FOC06_26815 ENOG4105VFE sira family FOC06_26820 ENOG4107TPS domain protein FOC06_26825 ENOG4105VFE sira family FOC06_26830 ENOG41085GJ domain protein FOC06_26840 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC06_26845 ENOG41087NI Sulfite exporter TauE/SafE FOC06_26855 ENOG4108KGH TRANSCRIPTIONal FOC06_26880 ENOG4105EMD TRANSCRIPTIONal FOC06_26885 ENOG4105VCP PTS System FOC06_26890 ENOG4105VZJ PTS System FOC06_26910 ENOG41069ER domain protein FOC06_26915 ENOG4107RBB ABC transporter, permease FOC06_26920 ENOG4105C19 ABC transporter FOC06_26950 ENOG4105WEF catalase FOC06_26985 ENOG4107T5V SNARE associated Golgi FOC06_27015 ENOG4105CUB amino acid FOC06_27020 ENOG4107RWR Sodium hydrogen exchanger FOC06_27030 ENOG4106KNT transcriptional regulator FOC06_27065 ENOG4108PCN EamA-like transporter family FOC06_27070 ENOG4108YXU transcriptional regulator AsnC family FOC06_27095 ENOG4105NF4 modulator of drug activity FOC06_27100 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC06_27105 ENOG4105E5W Transporter