locus-tag class description FOC09_00030 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC09_00040 ENOG4105T9C HD domain FOC09_00055 ENOG4105DZ1 carboxypeptidase FOC09_00070 ENOG4105DBI uridine monophosphokinase FOC09_00075 ENOG4105WCN acetyltransferase FOC09_00085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC09_00090 ENOG4107QX3 carboxylase FOC09_00095 ENOG4105E39 Enoyl-CoA hydratase FOC09_00100 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC09_00105 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC09_00110 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC09_00115 ENOG4105C1G acyl-Coa dehydrogenase FOC09_00130 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_00140 ENOG4105CJ1 ABC, transporter FOC09_00155 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC09_00160 ENOG4105CEP NADH dehydrogenase FOC09_00165 ENOG4106ANW SMI1_KNR4 FOC09_00180 ENOG4105BZU Histidine kinase FOC09_00190 ENOG4105C5H ABC transporter FOC09_00195 ENOG41067SE Tetr family transcriptional regulator FOC09_00215 ENOG4108VXD carboxy-peptidase FOC09_00230 ENOG4105VZ8 Transcriptional regulator FOC09_00260 ENOG4105DH8 myo-inositol catabolism FOC09_00265 ENOG4105D2N Aldolase FOC09_00290 ENOG4105CK5 oxidoreductase FOC09_00295 ENOG4105IE8 Alpha-ketoglutarate permease FOC09_00300 ENOG4105ETE Transcriptional regulator (LacI family FOC09_00305 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC09_00320 ENOG4107RF6 penicillin-binding protein FOC09_00345 ENOG4105CIN aminoacyl-histidine dipeptidase FOC09_00375 ENOG41090HR transcriptional regulator FOC09_00380 ENOG4107RA9 decarboxylase FOC09_00385 ENOG4108I0C methyltransferase FOC09_00395 ENOG41088CC tellurite resistance protein tehB FOC09_00415 ENOG4108RZE Tetr family transcriptional regulator FOC09_00430 ENOG4105C1J atp-dependent rna helicase FOC09_00445 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC09_00465 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC09_00475 ENOG4105RD7 BadF BadG BcrA BcrD FOC09_00525 ENOG4108KPJ rna polymerase sigma factor FOC09_00555 ENOG4108JCI Transcriptional regulator FOC09_00575 ENOG4105BZ1 (ABC) transporter FOC09_00580 ENOG4105BZ1 (ABC) transporter FOC09_00595 ENOG4108RPX mosc domain containing protein FOC09_00600 ENOG4105DND Transcriptional regulator FOC09_00615 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC09_00620 ENOG4107V2S Transcriptional regulator FOC09_00660 ENOG410667J hydrolase FOC09_00680 ENOG4105VEQ Cold shock protein FOC09_00690 ENOG41068WN FOC09_00700 ENOG4105C1Q protoporphyrinogen oxidase FOC09_00730 ENOG4105WCN acetyltransferase FOC09_00755 ENOG4105EYF MMPL domain protein FOC09_00765 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC09_00780 ENOG41081I9 integral membrane protein FOC09_00810 ENOG4108D32 Methyltransferase FOC09_00835 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC09_00850 ENOG4105C22 threonyL-tRNA synthetase FOC09_00855 ENOG4105FE9 pseudouridine synthase FOC09_00875 ENOG4105BZG amino acid carrier protein FOC09_00895 ENOG4105K70 DNA-binding protein FOC09_00910 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_00915 ENOG4105WQT MbtH domain protein FOC09_00920 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_00925 ENOG4105WQI isochorismatase FOC09_00930 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC09_00935 ENOG4105E4F Isochorismate synthase FOC09_00940 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC09_00945 ENOG4105FCD Major Facilitator FOC09_00965 ENOG4105EYH Exonuclease FOC09_00970 ENOG4107RFY SbcCD D subunit FOC09_00985 ENOG4105E39 Enoyl-CoA hydratase FOC09_00990 ENOG4105N14 lysine exporter protein LysE YggA FOC09_01000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC09_01005 ENOG4105C1G acyl-Coa dehydrogenase FOC09_01010 ENOG4105CR4 methylisocitrate lyase FOC09_01015 ENOG4105DXD 2-methylcitrate dehydratase FOC09_01025 ENOG4105W8X HesB YadR YfhF-family protein FOC09_01030 ENOG4105CZM Major Facilitator FOC09_01035 ENOG4105BZ4 penicillin-binding protein FOC09_01075 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_01180 ENOG4108IBT Inherit from COG: transposase FOC09_01195 ENOG4105SZ6 Thioredoxin FOC09_01205 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC09_01210 ENOG4108N23 SpoOM-related protein FOC09_01250 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC09_01255 ENOG4108JUB Transcriptional regulator FOC09_01260 ENOG4108TSC N-acetyltransferase FOC09_01265 ENOG4107S4Y M20 DapE family protein YgeY FOC09_01280 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_01305 ENOG4105C37 (CBS) domain FOC09_01340 ENOG4105E90 ABC transporter FOC09_01345 ENOG4108IJ8 ABC transporter FOC09_01370 ENOG4105CMG Carbohydrate kinase FOC09_01375 ENOG4105CMG Carbohydrate kinase FOC09_01410 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_01415 ENOG4105BZU Histidine kinase FOC09_01420 ENOG4105D8X mechanosensitive ion channel FOC09_01455 ENOG4105F0I Aminotransferase FOC09_01460 ENOG4108MES Periplasmic binding protein FOC09_01475 ENOG4105CAQ asparagine synthetase FOC09_01480 ENOG4107Y70 Heat shock protein FOC09_01485 ENOG4108KF3 Electron transport protein SCO1 SenC FOC09_01490 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC09_01495 ENOG4108RCR degv family FOC09_01505 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC09_01515 ENOG4108UT2 hemolysin iii FOC09_01520 ENOG4105E9Q Acyl-transferase FOC09_01525 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC09_01530 ENOG4107RVG penicillin-binding protein FOC09_01545 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC09_01565 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC09_01595 ENOG4105KD7 acetyltransferase FOC09_01610 ENOG4105C0A alcohol dehydrogenase FOC09_01615 ENOG4105CY2 Citrate transporter FOC09_01620 ENOG4107XGZ Hydrolase FOC09_01640 ENOG4105C8J )-transporter FOC09_01655 ENOG41062D9 Histidine kinase FOC09_01660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_01665 ENOG4107QPK )-transporter FOC09_01670 ENOG4105BZW Glycerate kinase FOC09_01740 ENOG4105EC2 ftsk spoIIIe FOC09_01760 ENOG4105C5S asparaginyl-tRNA synthetase FOC09_01780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC09_01805 ENOG4105C75 arginyL-tRNA synthetase FOC09_01810 ENOG4107YX5 Pfam:DUF548 FOC09_01840 ENOG4108UUM single-stranded DNA-binding protein FOC09_01855 ENOG4105C5H ABC transporter FOC09_01875 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC09_01890 ENOG4105MCT stage V sporulation protein S FOC09_01925 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC09_01930 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC09_01935 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC09_01940 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC09_01945 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC09_01950 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC09_01975 ENOG4108ZAF Molybdopterin FOC09_01980 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_01985 ENOG4105D06 uba thif-type nad fad binding protein FOC09_01990 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC09_01995 ENOG4107V6Q Cyclic nucleotide-binding domain FOC09_02020 ENOG4105R3A Nitrate reductase FOC09_02025 ENOG4108IUE nitrate reductase beta subunit FOC09_02045 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_02060 ENOG4108V06 Glutathione peroxidase FOC09_02085 ENOG4105EMN RNA polymerase sigma factor FOC09_02090 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC09_02100 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_02125 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC09_02150 ENOG4105KBJ sporulation protein ytfj FOC09_02200 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC09_02225 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC09_02230 ENOG4108JYZ YitT family FOC09_02235 ENOG41087PP glycosyltransferase MGT family FOC09_02250 ENOG4107RBS Methyltransferase FOC09_02255 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC09_02265 ENOG4108X4Q Hydrolase FOC09_02290 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC09_02300 ENOG4108VXD carboxy-peptidase FOC09_02310 ENOG4108ZRV stage ii sporulation protein p FOC09_02330 ENOG4108Z7R Chaperone CsaA FOC09_02350 ENOG4105C37 (CBS) domain FOC09_02355 ENOG4105SXS Protein of unknown function (DUF456) FOC09_02375 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_02385 ENOG4108S4H thioesterase Superfamily protein FOC09_02395 ENOG4108PJD permease FOC09_02410 ENOG4107T5V SNARE associated Golgi FOC09_02430 ENOG4105CVJ phosphoglycerate mutase FOC09_02455 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC09_02465 ENOG4105K4T epimerase FOC09_02470 ENOG4105DSE periplasmic solute binding protein FOC09_02525 ENOG4105CKI cobalamin synthesis protein FOC09_02530 ENOG4107QM2 Aldo Keto reductase FOC09_02550 ENOG4105DEN Luciferase family FOC09_02565 ENOG4108WPJ Ferritin-like domain FOC09_02570 ENOG4108K88 Membrane FOC09_02585 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_02610 ENOG4107XZQ multidrug resistance protein FOC09_02615 ENOG4107SET aldo keto reductase FOC09_02620 ENOG4105YVS arsR family transcriptional regulator FOC09_02630 ENOG4105KRN Transcriptional regulator, abrb family FOC09_02680 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC09_02690 ENOG4105YWU small acid-soluble spore protein FOC09_02695 ENOG4108WBH protein TIM barrel FOC09_02710 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_02715 ENOG4105DUU IucA IucC family protein FOC09_02725 ENOG4105VRR gCN5-related N-acetyltransferase FOC09_02730 ENOG4105KT7 mgtC SapB transporter FOC09_02740 ENOG4107VMI polysaccharide deacetylase FOC09_02745 ENOG4105BZU Histidine kinase FOC09_02750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_02760 ENOG4108KGH TRANSCRIPTIONal FOC09_02785 ENOG4105D6E homoserine dehydrogenase FOC09_02805 ENOG4108ZJ4 polysaccharide deacetylase FOC09_02810 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC09_02830 ENOG4105BZU Histidine kinase FOC09_02835 ENOG4105EFI regulatoR FOC09_02885 ENOG4108JJ8 (ABC) transporter FOC09_02890 ENOG4108JJ9 ABC, transporter FOC09_02895 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC09_02900 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC09_02910 ENOG4105YGB Transcriptional regulator FOC09_02930 ENOG4105SKE transcriptional Regulator LysR family FOC09_02940 ENOG4105C32 Amino acid ABC transporter (Permease) FOC09_02945 ENOG4108IV0 ABC, transporter FOC09_02950 ENOG4105C0Z ABC transporter FOC09_02960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_02965 ENOG4108Z7G MaoC domain protein dehydratase FOC09_02985 ENOG4105CKI cobalamin synthesis protein FOC09_02995 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_03000 ENOG4106F5Q Membrane FOC09_03005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC09_03010 ENOG4108TVJ Nitroreductase FOC09_03015 ENOG4107ZXU DSBA oxidoreductase FOC09_03020 ENOG4108Z40 Transcriptional regulator FOC09_03025 ENOG4105GZI Transcriptional regulator FOC09_03030 ENOG4107RT3 EamA-like transporter family FOC09_03040 ENOG4105KTB nuclear export factor GLE1 FOC09_03045 ENOG4108T5E Copper resistance protein FOC09_03090 ENOG4107STQ Multicopper oxidase FOC09_03095 ENOG4107RAQ aminopeptidase FOC09_03130 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC09_03135 ENOG4105D9N nucleoside FOC09_03145 ENOG4107RHR regulatoR FOC09_03175 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC09_03185 ENOG4105C72 UPF0176 protein FOC09_03190 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC09_03210 ENOG41068WN FOC09_03245 ENOG4105F6J Alpha beta hydrolase fold FOC09_03265 ENOG4105CYC Transferase FOC09_03270 ENOG4105DY9 regulatoR FOC09_03280 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC09_03285 ENOG4105C6X Major Facilitator FOC09_03310 ENOG4105C7B Threonine dehydratase FOC09_03320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC09_03325 ENOG4108ZP8 Acetolactate synthase small subunit FOC09_03330 ENOG4105C7K acetolactate synthase FOC09_03335 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC09_03340 ENOG4105CHR reductase FOC09_03345 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC09_03360 ENOG4106KE4 Dehydrogenase FOC09_03375 ENOG4105H67 Protein of unknown function (DUF421) FOC09_03380 ENOG4105X5K response regulator receiver protein FOC09_03390 ENOG4105C8J )-transporter FOC09_03410 ENOG4105C6T cysteine synthase FOC09_03415 ENOG4105EU0 Major facilitator Superfamily FOC09_03425 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC09_03445 ENOG4105CSR polyphosphate kinase 2 FOC09_03485 ENOG4105FVX FOC09_03545 ENOG4105C6K Malic enzyme FOC09_03550 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_03560 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC09_03580 ENOG4105CJ1 ABC, transporter FOC09_03615 ENOG4106BRA Membrane FOC09_03645 ENOG4107QIV Cytochrome c biogenesis protein FOC09_03665 ENOG4105EC3 peptidase S51, dipeptidase E FOC09_03690 ENOG4105C9Q fumarate hydratase class II FOC09_03695 ENOG4105DFD Na H antiporter FOC09_03710 ENOG4108PJD permease FOC09_03715 ENOG4105CKI cobalamin synthesis protein FOC09_03720 ENOG4108UZ3 Transporter FOC09_03725 ENOG4105DRR Transcriptional regulator, GntR family FOC09_03735 ENOG4105PGM cation diffusion facilitator family transporter FOC09_03755 ENOG4105CAQ asparagine synthetase FOC09_03785 ENOG4105CVJ phosphoglycerate mutase FOC09_03825 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC09_03830 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC09_03835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC09_03840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_03845 ENOG4105DUM transcriptional regulator, lysR family FOC09_03870 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC09_03890 ENOG4108RZE Tetr family transcriptional regulator FOC09_03915 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_03920 ENOG4105KTQ flagellar basal-body rod protein FOC09_03930 ENOG4105D7B Flagellar biosynthesis protein flha FOC09_03935 ENOG4105D00 flagellar biosynthetic protein flhB FOC09_03945 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC09_03950 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC09_03960 ENOG4105DD5 Flagellar motor switch protein FOC09_03975 ENOG4105E4C Lytic transglycosylase catalytic FOC09_03980 ENOG4105I03 Flagellin FOC09_04015 ENOG4105K64 Glycosyl transferase, family 2 FOC09_04040 ENOG4105BZE flagellar hook protein, FlgE FOC09_04075 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC09_04085 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC09_04090 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC09_04095 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC09_04120 ENOG4105E1Q flagellar hook-associated protein FOC09_04140 ENOG4105BZU Histidine kinase FOC09_04155 ENOG4105DD5 Flagellar motor switch protein FOC09_04165 ENOG4107YTP response regulator receiver protein FOC09_04170 ENOG4105ER2 Ompa motb domain protein FOC09_04175 ENOG4107R0U MotA TolQ exbB proton channel FOC09_04185 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC09_04240 ENOG41080C8 DUF218 domain FOC09_04245 ENOG4105H67 Protein of unknown function (DUF421) FOC09_04255 ENOG4108Z5V transcriptional regulator, merr family FOC09_04265 ENOG4107RWR Sodium hydrogen exchanger FOC09_04275 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_04340 ENOG41081VK Ribonuclease FOC09_04360 ENOG4108SZE gCN5-related N-acetyltransferase FOC09_04460 ENOG4105KHC sulfurtransferase FOC09_04470 ENOG4108W0I acetyltransferase FOC09_04480 ENOG410890F Dynamin family FOC09_04485 ENOG4105DHF Membrane FOC09_04490 ENOG4105C2W permease FOC09_04505 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_04520 ENOG4105CTD carboxy-peptidase FOC09_04525 ENOG4105DVT helicase FOC09_04535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC09_04590 ENOG4105BZ4 penicillin-binding protein FOC09_04600 ENOG4105CSM endonuclease III FOC09_04620 ENOG4105YAC FOC09_04625 ENOG4105DVT helicase FOC09_04660 ENOG4105CPK Glycosyl transferase (Group 1 FOC09_04665 ENOG4105FJR Lmbe family FOC09_04680 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC09_04685 ENOG4108JYZ YitT family FOC09_04715 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC09_04720 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC09_04725 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC09_04740 ENOG41068YB TPR repeat-containing protein FOC09_04745 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC09_04765 ENOG4105EAH synthase FOC09_04775 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC09_04790 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC09_04820 ENOG41065D1 FOC09_04825 ENOG4105S2F FOC09_04860 ENOG4105HDK L-asparaginase FOC09_04865 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC09_04890 ENOG4108S6Z Negative regulator of genetic competence FOC09_04895 ENOG4107X2D transcriptional regulator, merr family FOC09_04910 ENOG4105I7S Abortive infection protein FOC09_04915 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC09_04920 ENOG4105T7X FOC09_04930 ENOG4108SAX Membrane FOC09_04945 ENOG4108WBT adenosyltransferase FOC09_04950 ENOG4105BZU Histidine kinase FOC09_04955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_04960 ENOG4105CRE cytochrome C FOC09_04965 ENOG4107TWT Cytochrome c biogenesis protein FOC09_04975 ENOG4105FE9 pseudouridine synthase FOC09_04985 ENOG4108JIC nucleoside recognition domain protein FOC09_04990 ENOG4105DZ1 carboxypeptidase FOC09_04995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_05030 ENOG4105BZU Histidine kinase FOC09_05045 ENOG4105I3N Conserved Protein FOC09_05065 ENOG4105BZ4 penicillin-binding protein FOC09_05070 ENOG4107GRR phosphate transport regulator FOC09_05075 ENOG4105CJ3 phosphate transporter FOC09_05095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC09_05120 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC09_05140 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_05145 ENOG4105ENE Histidine kinase FOC09_05165 ENOG4105DFD Na H antiporter FOC09_05185 ENOG4105C8J )-transporter FOC09_05190 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC09_05195 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC09_05200 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC09_05210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC09_05215 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC09_05235 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC09_05245 ENOG4105E0M Sulfatase FOC09_05250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC09_05265 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC09_05300 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC09_05325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC09_05335 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC09_05340 ENOG4108ZP8 Acetolactate synthase small subunit FOC09_05345 ENOG4105C7K acetolactate synthase FOC09_05350 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC09_05375 ENOG4105KBJ sporulation protein ytfj FOC09_05380 ENOG41063Y9 FOC09_05385 ENOG4105CZN Potassium uptake protein FOC09_05415 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_05420 ENOG4107QMU Mate efflux family protein FOC09_05445 ENOG4105NQC Flavodoxin FOC09_05465 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_05475 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC09_05480 ENOG4105EA8 2-Nitropropane dioxygenase FOC09_05485 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC09_05525 ENOG4105CJ1 ABC, transporter FOC09_05535 ENOG4105CZV ABC transporter FOC09_05540 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC09_05545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC09_05565 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC09_05600 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC09_05605 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC09_05615 ENOG4105BZU Histidine kinase FOC09_05620 ENOG4106DF1 FOC09_05630 ENOG41090MY MarR family Transcriptional regulator FOC09_05635 ENOG4105BZU Histidine kinase FOC09_05645 ENOG4105PXI polysaccharide deacetylase FOC09_05665 ENOG4105E98 transcriptional regulator DeoR family FOC09_05680 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC09_05695 ENOG4105C4Y ABC transporter FOC09_05710 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC09_05720 ENOG4105CHR reductase FOC09_05740 ENOG4108Z7G MaoC domain protein dehydratase FOC09_05745 ENOG410681C small acid-soluble spore protein FOC09_05750 ENOG4105CZN Potassium uptake protein FOC09_05755 ENOG4107TS3 membrane protein, TerC FOC09_05760 ENOG4108QTI )-transporter FOC09_05770 ENOG4106A3R peptidase FOC09_05790 ENOG4105JXH GntR family transcriptional regulator FOC09_05795 ENOG4105BZU Histidine kinase FOC09_05800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_05815 ENOG4105CQB FAD linked oxidase domain protein FOC09_05820 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC09_05825 ENOG4105K4I Scp-like extracellular FOC09_05835 ENOG4108YBP pseudouridine synthase FOC09_05845 ENOG4105EYF MMPL domain protein FOC09_05855 ENOG4107RUE extracellular solute-binding protein family 1 FOC09_05860 ENOG4105D38 putrescine abc transporter FOC09_05865 ENOG4105F38 ABC transporter, permease FOC09_05870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_05875 ENOG4105C26 Dehydrogenase FOC09_05910 ENOG4105VFR signal peptidase FOC09_05915 ENOG4105DZ1 carboxypeptidase FOC09_05925 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC09_05985 ENOG4105VZ8 Transcriptional regulator FOC09_05995 ENOG4105C7S Dehydrogenase FOC09_06090 ENOG4105DDQ anthranilate synthase FOC09_06095 ENOG4105CRQ synthase (Component I) FOC09_06100 ENOG4105CK7 Sodium proline symporter FOC09_06125 ENOG4108WVJ 2'-5' rna ligase FOC09_06175 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC09_06185 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC09_06190 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC09_06210 ENOG4107TVC Glycosyl transferase, family 2 FOC09_06230 ENOG4105K64 Glycosyl transferase, family 2 FOC09_06250 ENOG4105EMS pseudouridine synthase FOC09_06255 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC09_06270 ENOG4105MIX Adenylate cyclase FOC09_06275 ENOG4108Z18 K06886 hemoglobin FOC09_06285 ENOG4105DPN Oligoendopeptidase f FOC09_06295 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_06305 ENOG4108ZCF integral membrane protein FOC09_06325 ENOG4105UQX Mate efflux family protein FOC09_06330 ENOG4108JQ7 (ABC) transporter FOC09_06340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_06345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_06360 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC09_06375 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC09_06380 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_06405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC09_06415 ENOG4108KP7 hydrolase FOC09_06425 ENOG41073B9 FOC09_06430 ENOG4107AYK membrAne FOC09_06440 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_06450 ENOG4105QNR S1 RNA binding domain protein FOC09_06475 ENOG4105CH6 catalase FOC09_06480 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC09_06485 ENOG4105CAQ asparagine synthetase FOC09_06510 ENOG4105ERH Fumarylacetoacetate hydrolase FOC09_06555 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC09_06560 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC09_06575 ENOG4105XVF Competence transcription factor FOC09_06590 ENOG4105VEQ Cold shock protein FOC09_06605 ENOG4107QP3 malate synthase g FOC09_06610 ENOG4105ZU5 s-layer protein FOC09_06630 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_06635 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC09_06660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_06675 ENOG41086D8 Transcriptional regulator FOC09_06680 ENOG4108AEY RNA polymerase sigma factor FOC09_06690 ENOG4107TVP HD domain protein FOC09_06725 ENOG4105CNA YD repeat protein FOC09_06755 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_06765 ENOG4105DF9 Lipoate-protein, ligase FOC09_06770 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC09_06775 ENOG4106AXD FOC09_06805 ENOG4105ECB domain protein FOC09_06820 ENOG4105NA0 Transcriptional regulator FOC09_06845 ENOG4105C1Q protoporphyrinogen oxidase FOC09_06855 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC09_06860 ENOG4105BZ4 penicillin-binding protein FOC09_06865 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC09_06870 ENOG4105CKV Membrane FOC09_06875 ENOG410905X membrane-flanked domain protein FOC09_06920 ENOG410905X membrane-flanked domain protein FOC09_06950 ENOG4105K59 histidine triad (HIT) protein FOC09_06975 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC09_06980 ENOG4105EEM helicase FOC09_06990 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_06995 ENOG4105C57 major facilitator superfamily FOC09_07020 ENOG4105EMN RNA polymerase sigma factor FOC09_07030 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC09_07045 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC09_07065 ENOG4108MUZ hydrolase FOC09_07085 ENOG4105EQ0 Major Facilitator superfamily FOC09_07090 ENOG4108IND Tetr family transcriptional regulator FOC09_07105 ENOG4105D7V transposase FOC09_07115 ENOG4107VRP DNA repair exonuclease FOC09_07145 ENOG4105K8R UPF0145 protein FOC09_07165 ENOG4105BZU Histidine kinase FOC09_07170 ENOG4105BZU Histidine kinase FOC09_07175 ENOG4108MJI response regulator FOC09_07185 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_07195 ENOG4105WN5 stage II sporulation protein FOC09_07260 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC09_07290 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC09_07295 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC09_07300 ENOG4105CMT Dihydroxyacetone kinase FOC09_07310 ENOG4105CMT Dihydroxyacetone kinase FOC09_07330 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC09_07350 ENOG4108IG5 Transcriptional regulator FOC09_07355 ENOG4107P5I polyketide synthase FOC09_07400 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_07430 ENOG4105CDU Replicative dna helicase FOC09_07480 ENOG4108MRH transcriptional regulatory protein FOC09_07490 ENOG4105CSH Transporter FOC09_07520 ENOG4105PKS Excinuclease abc c subunit domain protein FOC09_07525 ENOG4108JQ7 (ABC) transporter FOC09_07535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_07575 ENOG4105CTU Proline racemase FOC09_07595 ENOG4105DER m42 family FOC09_07615 ENOG4105CGU Enoyl-CoA hydratase FOC09_07630 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_07635 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC09_07645 ENOG4106AKK s-layer domain-containing protein FOC09_07685 ENOG4105CHH sulfate transporter FOC09_07700 ENOG4105D4P Coproporphyrinogen iii oxidase FOC09_07730 ENOG4107FQX Alpha-acetolactate decarboxylase FOC09_07765 ENOG410839P FOC09_07780 ENOG4105CDA abc transporter atp-binding protein FOC09_07785 ENOG4105DRP amino acid AbC transporter FOC09_07800 ENOG4105BZ1 (ABC) transporter FOC09_07805 ENOG4105C26 Dehydrogenase FOC09_07815 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC09_07820 ENOG4105D5Q Arginine ornithine antiporter FOC09_07830 ENOG4105CH6 catalase FOC09_07835 ENOG4107RKG DJ-1/PfpI family FOC09_07845 ENOG4105E5W Transporter FOC09_07850 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC09_07855 ENOG4105NF4 modulator of drug activity FOC09_07880 ENOG4105KPY Small multidrug resistance protein FOC09_07885 ENOG4105KPY Small multidrug resistance protein FOC09_07895 ENOG4108YXU transcriptional regulator AsnC family FOC09_07900 ENOG4108PCN EamA-like transporter family FOC09_07935 ENOG4106KNT transcriptional regulator FOC09_07945 ENOG4107RWR Sodium hydrogen exchanger FOC09_07950 ENOG4105CUB amino acid FOC09_07980 ENOG4107T5V SNARE associated Golgi FOC09_08015 ENOG4105WEF catalase FOC09_08045 ENOG4105C19 ABC transporter FOC09_08050 ENOG4107RBB ABC transporter, permease FOC09_08055 ENOG41069ER domain protein FOC09_08075 ENOG4105VZJ PTS System FOC09_08080 ENOG4105VCP PTS System FOC09_08085 ENOG4105EMD TRANSCRIPTIONal FOC09_08110 ENOG4108KGH TRANSCRIPTIONal FOC09_08120 ENOG41087NI Sulfite exporter TauE/SafE FOC09_08125 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC09_08135 ENOG41085GJ domain protein FOC09_08140 ENOG4105VFE sira family FOC09_08145 ENOG4107TPS domain protein FOC09_08150 ENOG4105VFE sira family FOC09_08155 ENOG4105XTG Pfam:DUF156 FOC09_08160 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC09_08185 ENOG4105ED1 spovr family FOC09_08190 ENOG4107Y03 Nitroreductase FOC09_08245 ENOG4105C5Y PTS System FOC09_08275 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_08290 ENOG4108INS Transcriptional regulator FOC09_08340 ENOG4105DWF phosphomethylpyrimidine kinase FOC09_08345 ENOG4105D06 uba thif-type nad fad binding protein FOC09_08360 ENOG41080HI glycine oxidase FOC09_08365 ENOG4108VEU Thiamine monophosphate synthase FOC09_08375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC09_08385 ENOG4105ETU transcriptional activator (TenA FOC09_08405 ENOG41080XQ Signal transduction protein with cbs domains FOC09_08530 ENOG4105E2Z phosphate ABC transporter (Permease FOC09_08535 ENOG4105C8U phosphate abc transporter FOC09_08540 ENOG4105CVA phosphate FOC09_08545 ENOG4105CE1 Ferrous iron transport protein b FOC09_08550 ENOG4105CE1 Ferrous iron transport protein b FOC09_08555 ENOG4105CE1 Ferrous iron transport protein b FOC09_08560 ENOG4108NHD germination protein FOC09_08575 ENOG4105E1V na solute symporter FOC09_08580 ENOG4106CAD Protein of unknown function (DUF3311) FOC09_08595 ENOG4108IQI permease FOC09_08600 ENOG4105E2S oxidase) subunit II FOC09_08605 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC09_08645 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_08650 ENOG4105C85 amino acid FOC09_08670 ENOG4105DUX Transporter FOC09_08680 ENOG4107D63 FOC09_08685 ENOG4105VZ8 Transcriptional regulator FOC09_08690 ENOG41069ER domain protein FOC09_08695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC09_08700 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_08760 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC09_08765 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC09_08770 ENOG4105CNN ABC, transporter FOC09_08775 ENOG4105C2J ABC transporter FOC09_08785 ENOG4108RVA ribokinase FOC09_08790 ENOG4105ETE Transcriptional regulator (LacI family FOC09_08800 ENOG41067TZ transcriptional regulator, MarR family FOC09_08805 ENOG4105CXY transporter FOC09_08815 ENOG4108JQ7 (ABC) transporter FOC09_08820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_08830 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC09_08840 ENOG41068KF Universal stress protein FOC09_08845 ENOG4105CHH sulfate transporter FOC09_08860 ENOG4105BZU Histidine kinase FOC09_08865 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC09_08870 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC09_08895 ENOG4108IQI permease FOC09_08900 ENOG4105DRP amino acid AbC transporter FOC09_08905 ENOG4105EAD ABC transporter FOC09_08910 ENOG4105CT1 (ABC) transporter FOC09_08915 ENOG4105CDA abc transporter atp-binding protein FOC09_08920 ENOG4105BZG amino acid carrier protein FOC09_08925 ENOG4105CRN Aminoglycoside phosphotransferase FOC09_08935 ENOG4105E1K spore germination protein FOC09_08950 ENOG4105CG3 alpha amylase, catalytic region FOC09_08955 ENOG4105C5Y PTS System FOC09_08960 ENOG4107414 GntR family transcriptional regulator FOC09_08965 ENOG4105D5Q Arginine ornithine antiporter FOC09_08970 ENOG4105BZU Histidine kinase FOC09_08985 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC09_08990 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC09_08995 ENOG4107T89 von Willebrand factor, type A FOC09_09005 ENOG4105EXW epimerase dehydratase FOC09_09015 ENOG4105DMQ Methyltransferase FOC09_09020 ENOG4105E0A ABC, transporter FOC09_09025 ENOG4108IHU transport system permease protein FOC09_09030 ENOG4105DQ5 transport system permease protein FOC09_09035 ENOG4108MES Periplasmic binding protein FOC09_09040 ENOG4105DUX Transporter FOC09_09055 ENOG4105DAA L-lactate FOC09_09060 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_09065 ENOG4105C37 (CBS) domain FOC09_09070 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC09_09075 ENOG4105D9N nucleoside FOC09_09080 ENOG4108KGH TRANSCRIPTIONal FOC09_09085 ENOG41073R8 VanW family FOC09_09120 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC09_09125 ENOG4105C59 p-type ATPase FOC09_09135 ENOG4105CUB amino acid FOC09_09155 ENOG4108JB9 formate dehydrogenase FOC09_09160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC09_09165 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC09_09170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_09175 ENOG4105BZU Histidine kinase FOC09_09185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC09_09190 ENOG4108UZ3 Transporter FOC09_09200 ENOG4105C6K Malic enzyme FOC09_09210 ENOG4108MRH transcriptional regulatory protein FOC09_09235 ENOG4105US7 Histidine kinase FOC09_09240 ENOG4108STX response regulator FOC09_09245 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC09_09250 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC09_09255 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC09_09260 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC09_09265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC09_09270 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC09_09290 ENOG4105D4T Citrate transporter FOC09_09300 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC09_09310 ENOG4105DZ6 Band 7 protein FOC09_09325 ENOG4105C94 Transporter FOC09_09345 ENOG4105CYN Serine protein kinase FOC09_09350 ENOG4105BZU Histidine kinase FOC09_09355 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC09_09365 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC09_09375 ENOG4107ZQN disulfide bond FOC09_09380 ENOG4108JQC penicillin-binding protein 1A FOC09_09495 ENOG4105G5W regulator Fur family FOC09_09500 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC09_09520 ENOG4108IUW ABC transporter FOC09_09530 ENOG4105CBC glutamate synthase FOC09_09535 ENOG4107NBY Membrane FOC09_09540 ENOG4105BZ1 (ABC) transporter FOC09_09560 ENOG4106BXE FOC09_09565 ENOG4105CEN a g-specific adenine glycosylase FOC09_09570 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC09_09600 ENOG4105ECP epimerase FOC09_09605 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC09_09625 ENOG4105F1A Pyruvate formate-lyase FOC09_09645 ENOG4105C3I Nad-dependent epimerase dehydratase FOC09_09650 ENOG4107QQG Dehydrogenase FOC09_09660 ENOG4105CKK Glycosyl transferase, family 2 FOC09_09675 ENOG4108A04 Beta-lactamase FOC09_09685 ENOG4105CSV Glutaminase FOC09_09710 ENOG4108IQI permease FOC09_09720 ENOG4108JUB Transcriptional regulator FOC09_09730 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC09_09985 ENOG4108IMY Transcriptional regulator FOC09_09990 ENOG4105VTR Integrase FOC09_09995 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC09_10035 ENOG4105UPD Calcium Proton FOC09_10040 ENOG410606W general stress protein FOC09_10055 ENOG4107ZTW SNARE associated Golgi FOC09_10075 ENOG4108IPJ Membrane FOC09_10080 ENOG4105C59 p-type ATPase FOC09_10085 ENOG4107U9T Pfam:Ribonuclease_BN FOC09_10095 ENOG4105KJF protein tyrosine phosphatase FOC09_10115 ENOG4108TTB tellurium resistance protein FOC09_10120 ENOG4107TS3 membrane protein, TerC FOC09_10125 ENOG4106FN3 tellurium resistance protein FOC09_10130 ENOG4106FN3 tellurium resistance protein FOC09_10135 ENOG4108N0M stress protein FOC09_10150 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC09_10165 ENOG4105DEU major facilitator superfamily FOC09_10185 ENOG41062JF Transcriptional regulator FOC09_10210 ENOG4105C5H ABC transporter FOC09_10225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC09_10240 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC09_10270 ENOG4105CI1 PTS System FOC09_10280 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_10285 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_10295 ENOG4105EAB amino acid AbC transporter FOC09_10300 ENOG4105E5Q amino acid AbC transporter FOC09_10315 ENOG4105D2S major facilitator superfamily FOC09_10320 ENOG410756H nucleotidyltransferase FOC09_10340 ENOG4105BZU Histidine kinase FOC09_10365 ENOG4106UIA FOC09_10370 ENOG4106UIA FOC09_10390 ENOG4108V5C ABC transporter FOC09_10395 ENOG4105DQ5 transport system permease protein FOC09_10400 ENOG4105EHG Permease protein FOC09_10405 ENOG4107W7X Aldolase FOC09_10415 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC09_10420 ENOG4105D3R alkyl hydroperoxide reductase FOC09_10440 ENOG4105DFD Na H antiporter FOC09_10450 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_10465 ENOG4108W15 Protein of unknown function (DUF1456) FOC09_10480 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC09_10485 ENOG4105D9N nucleoside FOC09_10505 ENOG4105KPY Small multidrug resistance protein FOC09_10510 ENOG4105C26 Dehydrogenase FOC09_10520 ENOG4108JPW Aminotransferase FOC09_10525 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC09_10530 ENOG4105CBD Diacylglycerol kinase FOC09_10555 ENOG410834F Transcriptional regulator FOC09_10575 ENOG4105D01 (LipO)protein FOC09_10580 ENOG4108UMI ABC transporter, permease FOC09_10585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_10590 ENOG4108W2Y isochorismatase FOC09_10615 ENOG4105C4R Atp-dependent dna helicase FOC09_10640 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC09_10650 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC09_10675 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC09_10685 ENOG4105C83 adenylosuccinate lyase FOC09_10690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC09_10695 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC09_10715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_10735 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC09_10775 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_10810 ENOG4105BZU Histidine kinase FOC09_10820 ENOG4105C7N Xanthine uracil vitamin C permease FOC09_10840 ENOG4108TYN CAAX amino terminal protease family protein FOC09_10855 ENOG4105C5H ABC transporter FOC09_10860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC09_10865 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC09_10870 ENOG41072GX Peptidase M22 Glycoprotease FOC09_10875 ENOG4105K8N protein family UPF0079, ATPase FOC09_10975 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC09_10985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC09_10990 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC09_11000 ENOG4107ZXI Rhomboid family FOC09_11015 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC09_11025 ENOG4108SC4 )-transporter FOC09_11035 ENOG4105ERH Fumarylacetoacetate hydrolase FOC09_11040 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC09_11060 ENOG4108JQ7 (ABC) transporter FOC09_11065 ENOG4105C3U ABC transporter FOC09_11070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_11080 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC09_11095 ENOG4105C5H ABC transporter FOC09_11120 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC09_11125 ENOG4108RE7 deoxyribonuclease FOC09_11135 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC09_11155 ENOG4105F6E Acyl-transferase FOC09_11175 ENOG4105EGI Transcriptional regulator FOC09_11185 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC09_11195 ENOG4105E0C molybdate abc transporter FOC09_11205 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC09_11210 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_11220 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC09_11225 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC09_11255 ENOG4108JQ7 (ABC) transporter FOC09_11260 ENOG4105C3U ABC transporter FOC09_11265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_11270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC09_11285 ENOG4105C2C drug resistance transporter, Bcr CflA FOC09_11300 ENOG4105IQ5 FAD linked oxidase domain protein FOC09_11310 ENOG4105EE1 crotonyl-CoA reductase FOC09_11315 ENOG4105D01 (LipO)protein FOC09_11320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_11325 ENOG4108UMI ABC transporter, permease FOC09_11360 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC09_11365 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC09_11385 ENOG4108VQT Alpha beta hydrolase fold protein FOC09_11390 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC09_11405 ENOG4107U5W ybbr family FOC09_11410 ENOG4105C8B TIGR00159 family FOC09_11490 ENOG4108NMV polysaccharide deacetylase FOC09_11505 ENOG4105D1F ATP-binding protein FOC09_11530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC09_11535 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC09_11540 ENOG4108JJB ABC transporter FOC09_11570 ENOG41067V7 50S ribosomal protein L36 FOC09_11580 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_11590 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC09_11615 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC09_11720 ENOG4105XPM ribosomal protein FOC09_11725 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC09_11735 ENOG4107Y49 methyltransferase FOC09_11760 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC09_11775 ENOG4105QIV RNA polymerase FOC09_11780 ENOG4105M0M Tetracycline resistance protein FOC09_11785 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC09_11800 ENOG4105D7W serine acetyltransferase FOC09_11820 ENOG4105CTP PilT protein domain protein FOC09_11830 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC09_11845 ENOG4108Z0C Uvrb UvrC protein FOC09_11875 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC09_11885 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC09_11890 ENOG4105KRF dihydroneopterin aldolase FOC09_11895 ENOG4105EEI dihydropteroate synthase FOC09_11900 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC09_11905 ENOG4105DDQ anthranilate synthase FOC09_11910 ENOG4105CRQ synthase (Component I) FOC09_11915 ENOG4105C6T cysteine synthase FOC09_11930 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC09_11935 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC09_11940 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC09_11960 ENOG41060GV RNA binding s1 domain protein FOC09_11975 ENOG4105VYY sporulation protein yabp FOC09_11980 ENOG41082I2 s4 domain protein FOC09_11985 ENOG4108IY2 MazG family FOC09_11995 ENOG4108M14 stage v sporulation protein t FOC09_12000 ENOG4108JA2 transcriptioN-repair coupling factor FOC09_12010 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC09_12015 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC09_12030 ENOG4105KME endoribonuclease L-psp FOC09_12035 ENOG4105DFT pur operon repressor FOC09_12050 ENOG4105W42 Veg protein FOC09_12055 ENOG4105XFA sporulation peptidase YabG FOC09_12065 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC09_12070 ENOG4105F8V Hydrolase, tatD family FOC09_12080 ENOG4105KRN Transcriptional regulator, abrb family FOC09_12085 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC09_12095 ENOG41060K3 Methyltransferase FOC09_12105 ENOG4105MA4 psp1 domain protein FOC09_12110 ENOG4105FA2 dna polymerase iii FOC09_12120 ENOG4105CXN decarboxylase FOC09_12155 ENOG41067KS pro-sigma K processing FOC09_12175 ENOG4105C6E dna polymerase iii FOC09_12185 ENOG4108Z6B deaminase FOC09_12190 ENOG4105GTG Isochorismatase FOC09_12200 ENOG4105ZMH deoxynucleoside kinase FOC09_12235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC09_12270 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC09_12285 ENOG410848D S4 domain protein YaaA FOC09_12290 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC09_12310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC09_12320 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC09_12340 ENOG4107QJE Chromosome Partitioning Protein FOC09_12345 ENOG4105FA0 parb-like partition protein FOC09_12350 ENOG4108ZDA Sporulation protein YyaC FOC09_12355 ENOG4105D8X mechanosensitive ion channel FOC09_12360 ENOG4105VDK protein, conserved in bacteria FOC09_12365 ENOG4105C3G gtp-binding protein FOC09_12375 ENOG4108UUM single-stranded DNA-binding protein FOC09_12385 ENOG4108XMW Membrane FOC09_12390 ENOG4105BZR domain protein FOC09_12400 ENOG4105CDU Replicative dna helicase FOC09_12430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_12435 ENOG4105BZU Histidine kinase FOC09_12450 ENOG4105Q2H domain protein FOC09_12455 ENOG4105C0H protease FOC09_12475 ENOG4105DPN Oligoendopeptidase f FOC09_12490 ENOG4105C1J atp-dependent rna helicase FOC09_12500 ENOG4108UT2 hemolysin iii FOC09_12505 ENOG4105CMR udp-glucose 4-epimerase FOC09_12515 ENOG4105IW1 AmiS UreI transporter FOC09_12525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_12540 ENOG4107RGD Major Facilitator superfamily FOC09_12545 ENOG4108HRK Histidine kinase FOC09_12550 ENOG4105DY9 regulatoR FOC09_12565 ENOG4106F5Q Membrane FOC09_12570 ENOG4105E0X reductase FOC09_12580 ENOG41067SE Tetr family transcriptional regulator FOC09_12585 ENOG4105CKK Glycosyl transferase, family 2 FOC09_12605 ENOG4105C5H ABC transporter FOC09_12610 ENOG4105JEU Glycosyl transferase, family 2 FOC09_12620 ENOG4108S4H thioesterase Superfamily protein FOC09_12630 ENOG4106YBV Methyl-accepting chemotaxis FOC09_12635 ENOG4105EN6 Membrane FOC09_12655 ENOG41079KZ Major Facilitator Superfamily FOC09_12660 ENOG4105DY9 regulatoR FOC09_12665 ENOG4105D22 carbon starvation protein FOC09_12670 ENOG4105VCD cytoplasmic protein FOC09_12675 ENOG4105BZU Histidine kinase FOC09_12680 ENOG4105DWF phosphomethylpyrimidine kinase FOC09_12690 ENOG4105WH1 Two component transcriptional regulator luxr family FOC09_12700 ENOG4108Y4K DNA-binding transcriptional activator FOC09_12725 ENOG4105D6E homoserine dehydrogenase FOC09_12740 ENOG41090WU lipolytic protein G-D-S-L family FOC09_12745 ENOG4105CJ1 ABC, transporter FOC09_12750 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC09_12760 ENOG4105VCH membrane FOC09_12765 ENOG410667J hydrolase FOC09_12795 ENOG4108VKI Cell wall hydrolase FOC09_12810 ENOG4108IJ2 phosphate acetyltransferase FOC09_12825 ENOG4108VCI transcription factor, rsfa family FOC09_12840 ENOG4105EHG Permease protein FOC09_12845 ENOG4105E0A ABC, transporter FOC09_12850 ENOG4108MES Periplasmic binding protein FOC09_12855 ENOG4105DCI Phosphohydrolase FOC09_12860 ENOG41069HH 4-oxalocrotonate tautomerase FOC09_12865 ENOG4108Z4T Peptidase M50 FOC09_12870 ENOG4108XFG YwhD family FOC09_12875 ENOG4105BZ4 penicillin-binding protein FOC09_12880 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC09_12885 ENOG4107SWG transcriptional regulator MERR family FOC09_12890 ENOG4105DXB Major Facilitator superfamily FOC09_12900 ENOG4105CYW agmatinase FOC09_12920 ENOG410684U Domain of unknown function (DUF1934) FOC09_12930 ENOG4105EMN RNA polymerase sigma factor FOC09_12950 ENOG4105IIU Aminopeptidase FOC09_12960 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC09_12965 ENOG4108M15 ABC transporter FOC09_12970 ENOG4105KCT ABC transporter FOC09_12975 ENOG4105BZU Histidine kinase FOC09_13005 ENOG4105BZU Histidine kinase FOC09_13020 ENOG4105DF6 Fe-S oxidoreductase FOC09_13030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC09_13035 ENOG4105C1G acyl-Coa dehydrogenase FOC09_13040 ENOG4105C1G acyl-Coa dehydrogenase FOC09_13075 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC09_13080 ENOG4105CBT Fructose-1,6-bisphosphatase FOC09_13085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC09_13100 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC09_13105 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC09_13110 ENOG4108ZXQ stage ii sporulation protein r FOC09_13120 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC09_13135 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC09_13140 ENOG4108VGI doxx family FOC09_13155 ENOG4108YZG isomerase FOC09_13185 ENOG41062M3 atp synthase FOC09_13190 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC09_13240 ENOG4105BZU Histidine kinase FOC09_13245 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC09_13255 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC09_13260 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC09_13285 ENOG4105D65 subunit l FOC09_13290 ENOG4105C8S subunit m FOC09_13295 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC09_13300 ENOG4106778 Protein of unknown function (DUF1146) FOC09_13320 ENOG4108IUW ABC transporter FOC09_13325 ENOG4105DY9 regulatoR FOC09_13340 ENOG4105FRN stage II sporulation protein FOC09_13355 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC09_13410 ENOG4105EY8 ABC transporter FOC09_13415 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC09_13430 ENOG4105CMR udp-glucose 4-epimerase FOC09_13435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_13440 ENOG4105BZU Histidine kinase FOC09_13455 ENOG4105CXY transporter FOC09_13475 ENOG4105C19 ABC transporter FOC09_13480 ENOG4107RBB ABC transporter, permease FOC09_13490 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_13520 ENOG4105C0D helicase FOC09_13525 ENOG4105KBK Zinc finger, swim domain protein FOC09_13550 ENOG41069ER domain protein FOC09_13555 ENOG4105C94 Transporter FOC09_13585 ENOG4105E0M Sulfatase FOC09_13595 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC09_13605 ENOG4105DAA L-lactate FOC09_13645 ENOG4107RSM transcriptional regulator FOC09_13650 ENOG4105ECB domain protein FOC09_13655 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_13670 ENOG4105VZJ PTS System FOC09_13680 ENOG4105VCP PTS System FOC09_13685 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC09_13690 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC09_13700 ENOG4105CK1 PTS System FOC09_13705 ENOG4105VCP PTS System FOC09_13710 ENOG4105F8D glycoside hydrolase family 4 FOC09_13715 ENOG410901P UPF0249 protein FOC09_13730 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC09_13740 ENOG4105ESV Glycosyl transferase, family 4 FOC09_13745 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC09_13750 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC09_13755 ENOG4108KGH TRANSCRIPTIONal FOC09_13760 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC09_13770 ENOG4105KVH Transcriptional regulator FOC09_13785 ENOG41081UC Inherit from COG: Competence protein FOC09_13790 ENOG4105VEQ Cold shock protein FOC09_13795 ENOG4105MS2 ribosomal subunit Interface protein FOC09_13800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC09_13820 ENOG4105CAK Cell division ATP-binding protein ftsE FOC09_13825 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC09_13830 ENOG4105CN1 protease FOC09_13840 ENOG4105BZ1 (ABC) transporter FOC09_13855 ENOG4108WS4 fmn reductase FOC09_13865 ENOG4105DUM transcriptional regulator, lysR family FOC09_13870 ENOG4105HMI Membrane FOC09_13895 ENOG4107TXC Transcriptional regulator FOC09_13910 ENOG4105D7V transposase FOC09_13915 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC09_13920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC09_13930 ENOG41086DT Membrane protein of unknown function FOC09_13950 ENOG4108S4C acetyltransferase FOC09_13960 ENOG4105C3M thioredoxin reductase FOC09_13970 ENOG4108Z4K mutator MutT protein FOC09_13980 ENOG4105CHW UPF0052 protein FOC09_13990 ENOG4105KRI phosphocarrier protein (HPr FOC09_13995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC09_14000 ENOG4105H67 Protein of unknown function (DUF421) FOC09_14015 ENOG4105CZ3 stage V sporulation protein ad FOC09_14020 ENOG41090VF Stage v sporulation protein ac FOC09_14040 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_14065 ENOG4105CP7 Triose-phosphate isomerase FOC09_14070 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC09_14080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC09_14105 ENOG4105EFC phage portal protein HK97 family FOC09_14200 ENOG41067MG lrgb family FOC09_14205 ENOG4105XZU Preprotein translocase, subunit SecG FOC09_14215 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC09_14245 ENOG4105CM4 permease protein FOC09_14250 ENOG4108IPW abc transporter atp-binding protein FOC09_14265 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC09_14270 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC09_14285 ENOG4105WMR Protein CrcB homolog FOC09_14290 ENOG4105WMR Protein CrcB homolog FOC09_14300 ENOG4105C8Q Methyl-accepting chemotaxis FOC09_14310 ENOG4105D4A Cell wall formation (By similarity) FOC09_14315 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC09_14330 ENOG4105KVH Transcriptional regulator FOC09_14335 ENOG4105F27 Major Facilitator FOC09_14340 ENOG4105CV8 reductase FOC09_14355 ENOG4108RYK Nad-dependent epimerase dehydratase FOC09_14370 ENOG4105D9N nucleoside FOC09_14375 ENOG4105D9N nucleoside FOC09_14395 ENOG4108URH decarboxylase FOC09_14410 ENOG4108RMU ferritin dps family protein FOC09_14420 ENOG4105NCW Trka-c domain protein FOC09_14425 ENOG4107S91 Sodium hydrogen exchanger FOC09_14445 ENOG4105D4Y metalloprotease FOC09_14450 ENOG4105VG1 fes assembly suf system protein FOC09_14465 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC09_14475 ENOG4105BZU Histidine kinase FOC09_14480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_14485 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC09_14495 ENOG4107ZTW SNARE associated Golgi FOC09_14530 ENOG4107AYK membrAne FOC09_14540 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC09_14550 ENOG4107R7I amino acid FOC09_14555 ENOG4108SUT Major Facilitator Superfamily FOC09_14570 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC09_14590 ENOG4105DZ1 carboxypeptidase FOC09_14605 ENOG4105CHU acetyl-coa acetyltransferase FOC09_14610 ENOG4105C1G acyl-Coa dehydrogenase FOC09_14615 ENOG4108W8B Beta-lactamase domain protein FOC09_14640 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_14685 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC09_14720 ENOG4108UMI ABC transporter, permease FOC09_14725 ENOG4105D01 (LipO)protein FOC09_14730 ENOG4105D01 (LipO)protein FOC09_14735 ENOG4105C3K feS assembly ATPase SufC FOC09_14740 ENOG4105JRK feS assembly protein SufD FOC09_14745 ENOG4105C9B Cysteine desulfurase FOC09_14750 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC09_14755 ENOG4105DIW FeS assembly protein SUFB FOC09_14770 ENOG4107R8B 5'-nucleotidase FOC09_14775 ENOG4105KZD Domain of unknown function (DUF1805) FOC09_14785 ENOG4105FAA peptidase M23 FOC09_14810 ENOG41090T1 Membrane FOC09_14815 ENOG4107TXC Transcriptional regulator FOC09_14820 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC09_14825 ENOG4105MMD transcriptional regulator FOC09_14840 ENOG4105CBT Fructose-1,6-bisphosphatase FOC09_14855 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC09_14860 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC09_14870 ENOG4108W5N phosphatidylglycerophosphatase a FOC09_14885 ENOG41083MR nifu domain-containing protein FOC09_14930 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC09_14935 ENOG4105C4B ABC transporter, permease FOC09_14940 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC09_14965 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC09_14985 ENOG4105EWC Purine nucleoside phosphorylase FOC09_15015 ENOG4105CEP NADH dehydrogenase FOC09_15030 ENOG41069ER domain protein FOC09_15050 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC09_15070 ENOG4105KA0 thioesterase Superfamily protein FOC09_15075 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC09_15090 ENOG4107R3E Citrate transporter FOC09_15100 ENOG4105Y38 Kinase-associated protein B FOC09_15110 ENOG4105C87 Aminotransferase class I and II FOC09_15120 ENOG4108MUZ hydrolase FOC09_15125 ENOG4105C5I Dehydrogenase FOC09_15130 ENOG4108ZB6 transcriptional regulator AsnC family FOC09_15135 ENOG4105CHM Aminotransferase FOC09_15145 ENOG4105WG9 Conserved Protein FOC09_15150 ENOG4107QYV phosphohexose isomerase FOC09_15160 ENOG4107PBV potassium channel FOC09_15165 ENOG4105KT7 mgtC SapB transporter FOC09_15200 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC09_15295 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC09_15315 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC09_15325 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC09_15345 ENOG4105VEQ Cold shock protein FOC09_15355 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC09_15360 ENOG4105E4F Isochorismate synthase FOC09_15365 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC09_15370 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC09_15375 ENOG4108IPT Naphthoate synthase FOC09_15385 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_15415 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC09_15435 ENOG4105FDP GntR family transcriptional regulator FOC09_15440 ENOG4105C6Z Gluconate FOC09_15480 ENOG41086D8 Transcriptional regulator FOC09_15485 ENOG4105C19 ABC transporter FOC09_15500 ENOG4107ZTW SNARE associated Golgi FOC09_15535 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC09_15540 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC09_15565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_15570 ENOG4105BZU Histidine kinase FOC09_15605 ENOG41087YS Phage shock protein A FOC09_15650 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC09_15655 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC09_15660 ENOG4108V2W Carbonate dehydratase FOC09_15715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC09_15725 ENOG4105D2X ABC transporter substrate-binding protein FOC09_15745 ENOG4107S9D Alpha beta hydrolase FOC09_15750 ENOG4105BZU Histidine kinase FOC09_15755 ENOG4105BZU Histidine kinase FOC09_15760 ENOG4105EGD dinuclear metal center protein, YbgI family FOC09_15810 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC09_15820 ENOG4105BZF Glycosyl transferase (Group 1 FOC09_15825 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC09_15830 ENOG4108Z0R Transferase FOC09_15835 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC09_15865 ENOG4105DA5 (ABC) transporter FOC09_15875 ENOG4105N5T Radical SAM Protein FOC09_15895 ENOG4105C19 ABC transporter FOC09_15910 ENOG4105NCW Trka-c domain protein FOC09_15915 ENOG4107S91 Sodium hydrogen exchanger FOC09_15920 ENOG410605W Major Facilitator FOC09_15955 ENOG4108B31 Spore germination protein FOC09_15965 ENOG4105DWV Homoserine O-trans-acetylase FOC09_15975 ENOG41085GJ domain protein FOC09_16000 ENOG4105D06 uba thif-type nad fad binding protein FOC09_16010 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_16015 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC09_16020 ENOG4108ZAF Molybdopterin FOC09_16035 ENOG4105CSC Glucose uptake protein FOC09_16040 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC09_16045 ENOG4108VJ1 Transcriptional regulator (CarD family FOC09_16080 ENOG4105CBX hi0933 family FOC09_16095 ENOG4105YW5 deoR family transcriptional regulator FOC09_16110 ENOG4108IUM Glycogen debranching enzyme FOC09_16115 ENOG4108V15 phosphotransferase enzyme family FOC09_16130 ENOG4105C8F Beta-lactamase domain protein FOC09_16160 ENOG4108VDD TRNA binding domain protein FOC09_16205 ENOG4105C88 aminopeptidase FOC09_16225 ENOG4105ETE Transcriptional regulator (LacI family FOC09_16255 ENOG4105EP9 oxidoreductase FOC09_16260 ENOG4107SNB ankyrin repeat protein YahD FOC09_16270 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_16280 ENOG4105DGU Histone deacetylase FOC09_16285 ENOG4105W87 Cbs domain FOC09_16290 ENOG4105F1V Acetoin utilization protein FOC09_16310 ENOG4105EMN RNA polymerase sigma factor FOC09_16320 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC09_16340 ENOG4105C28 cystathionine FOC09_16360 ENOG4106KR7 LysR family Transcriptional regulator FOC09_16385 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC09_16395 ENOG4105EFZ amidohydrolase FOC09_16410 ENOG4105KBJ sporulation protein ytfj FOC09_16415 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC09_16425 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC09_16445 ENOG4108JYZ YitT family FOC09_16485 ENOG4107YZX Universal stress protein FOC09_16505 ENOG4105VZ8 Transcriptional regulator FOC09_16515 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC09_16520 ENOG4105Z7P Acetyltransferase (GNAT) family FOC09_16555 ENOG4105DC7 peptidase M24 FOC09_16590 ENOG4105SFS phosphoesterase RecJ domain protein FOC09_16600 ENOG4105VV2 FOC09_16605 ENOG4105C0B DNA polymerase III (alpha subunit) FOC09_16610 ENOG4105C6K Malic enzyme FOC09_16615 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC09_16640 ENOG4105FS0 cytoplasmic membrane protein FOC09_16645 ENOG4108REF Sporulation integral membrane protein ytvi FOC09_16655 ENOG4105BZN citrate synthase FOC09_16660 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC09_16675 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_16680 ENOG4105BZU Histidine kinase FOC09_16685 ENOG4105C2M dna polymerase I FOC09_16690 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC09_16700 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC09_16705 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC09_16715 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC09_16735 ENOG4108TDW sporulation protein YtxC FOC09_16740 ENOG4105C22 threonyL-tRNA synthetase FOC09_16745 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC09_16765 ENOG4105CN9 Peptidase m42 family protein FOC09_16770 ENOG4108JGH Tetr family transcriptional regulator FOC09_16775 ENOG4105CW7 secretion protein, HlyD family FOC09_16780 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_16815 ENOG4108RWN rrna methyltransferase FOC09_16825 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC09_16830 ENOG4105C5S asparaginyl-tRNA synthetase FOC09_16865 ENOG4105DCG PHP domain protein FOC09_16875 ENOG4105FE9 pseudouridine synthase FOC09_16885 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC09_16895 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC09_16910 ENOG4105E0A ABC, transporter FOC09_16915 ENOG4105KFN sortase, SrtB family FOC09_16930 ENOG4105DR4 Methyltransferase FOC09_16940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC09_16980 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC09_16985 ENOG4105J76 Periplasmic binding protein FOC09_16995 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_17000 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_17005 ENOG41060WC Enoyl-CoA hydratase FOC09_17010 ENOG4105BZJ Electron transfer flavoprotein FOC09_17015 ENOG4105C10 Electron transfer flavoprotein FOC09_17020 ENOG4105K63 Thioredoxin FOC09_17035 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC09_17045 ENOG4105E33 succinate dehydrogenase FOC09_17055 ENOG4108VXD carboxy-peptidase FOC09_17060 ENOG4105E14 MotA TolQ exbB proton channel FOC09_17070 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC09_17075 ENOG4108IUX (ABC) transporter FOC09_17080 ENOG4105RHA ABC transporter, permease FOC09_17085 ENOG4108Z40 Transcriptional regulator FOC09_17090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC09_17100 ENOG4108JCI Transcriptional regulator FOC09_17105 ENOG41067S9 phage shock protein C, PspC FOC09_17120 ENOG4105DY9 regulatoR FOC09_17130 ENOG4108JQ7 (ABC) transporter FOC09_17145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC09_17150 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC09_17155 ENOG4105DZC cytosine deaminase FOC09_17160 ENOG4105DZC cytosine deaminase FOC09_17175 ENOG4105PFC Transcriptional regulator FOC09_17190 ENOG4105KBX Transcriptional regulator, TetR family FOC09_17200 ENOG4108PCX Major Facilitator FOC09_17210 ENOG4108XJQ germination protein FOC09_17220 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC09_17225 ENOG4105M59 Phosphodiesterase, mj0936 family FOC09_17245 ENOG4108QCI YvbH-like oligomerisation region FOC09_17270 ENOG4108IUQ atp-dependent protease FOC09_17290 ENOG4105K56 Transcriptional regulator FOC09_17315 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC09_17325 ENOG41068KH stage VI sporulation protein D FOC09_17335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC09_17340 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC09_17360 ENOG4105DFF Rod shape-determining protein mreb FOC09_17365 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC09_17380 ENOG4107QMS site-determining protein FOC09_17395 ENOG4105C03 ribonuclease FOC09_17405 ENOG4105X36 (ribosomal) protein FOC09_17420 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC09_17450 ENOG4105CQC Prephenate dehydratase FOC09_17455 ENOG4108RPX mosc domain containing protein FOC09_17470 ENOG4108IYU L-aspartate oxidase FOC09_17475 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC09_17500 ENOG41082BM Transcriptional regulator, arsr family FOC09_17505 ENOG4108IPJ Membrane FOC09_17510 ENOG4108IPJ Membrane FOC09_17520 ENOG4108HUF Transporter FOC09_17535 ENOG41061AI Protein of unknown function (DUF2905) FOC09_17550 ENOG4105VIE preprotein translocase, subunit YajC FOC09_17560 ENOG4108QG2 Membrane FOC09_17565 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC09_17575 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC09_17580 ENOG41076HS cation diffusion facilitator family transporter FOC09_17585 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC09_17595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC09_17605 ENOG4105CUT histidyl-tRNA synthetase FOC09_17615 ENOG4105CUZ uba thif-type nad fad binding protein FOC09_17620 ENOG4108VCI transcription factor, rsfa family FOC09_17625 ENOG4105D1H recombination factor protein RarA FOC09_17635 ENOG4105C3J Cysteine desulfurase FOC09_17640 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC09_17650 ENOG4105C7H Helicase, RecD TraA family FOC09_17655 ENOG41060CR FOC09_17670 ENOG4105C02 permease FOC09_17680 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_17700 ENOG4105HHA aminodeoxychorismate lyase FOC09_17705 ENOG4108VQJ O-methyltransferase FOC09_17710 ENOG4105XYU peptidase (U32 family) FOC09_17715 ENOG4105CFP Peptidase U32 FOC09_17730 ENOG4107XRG penicillin-binding protein FOC09_17760 ENOG4105C28 cystathionine FOC09_17765 ENOG4108EKI Dehydrogenase FOC09_17775 ENOG4108V5C ABC transporter FOC09_17780 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC09_17830 ENOG4105MIR Phenylalanine 4-monooxygenase FOC09_17835 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC09_17870 ENOG4108MUZ hydrolase FOC09_17880 ENOG4105G6Z alkaline phosphatase FOC09_17895 ENOG4108TVJ Nitroreductase FOC09_17915 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_17930 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC09_17935 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC09_17945 ENOG410812S Rna-binding protein FOC09_17955 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC09_17965 ENOG4105DXX methyltransferase FOC09_17975 ENOG4105KQC Competence protein FOC09_17980 ENOG4108UK2 deaminase FOC09_17985 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC09_17995 ENOG4105TQK DNA polymerase iii, delta' subunit FOC09_18020 ENOG4105KVH Transcriptional regulator FOC09_18025 ENOG4105CSA Coproporphyrinogen iii oxidase FOC09_18035 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC09_18055 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC09_18060 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC09_18070 ENOG4105KTH gatB Yqey FOC09_18075 ENOG41068P3 sporulation protein YqfC FOC09_18085 ENOG4105C9A Phoh family FOC09_18090 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC09_18100 ENOG4107YR5 Diacylglycerol kinase FOC09_18105 ENOG4105KG3 cytidine deaminase FOC09_18110 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC09_18140 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC09_18145 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_18160 ENOG4105EGD dinuclear metal center protein, YbgI family FOC09_18185 ENOG41069ZM Protein of unknown function (DUF2624) FOC09_18190 ENOG4108JYZ YitT family FOC09_18195 ENOG4105FDK ABC transporter FOC09_18205 ENOG4105N80 Ferric uptake regulator, Fur family FOC09_18230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC09_18240 ENOG4107RF6 penicillin-binding protein FOC09_18245 ENOG4105PWN phosphate abc transporter FOC09_18250 ENOG4105C8U phosphate abc transporter FOC09_18255 ENOG4105E2Z phosphate ABC transporter (Permease FOC09_18260 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC09_18265 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC09_18280 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC09_18290 ENOG4105DKQ ROK family FOC09_18300 ENOG4105C5X domain protein FOC09_18320 ENOG4105C28 cystathionine FOC09_18325 ENOG4105C28 cystathionine FOC09_18335 ENOG4105C3R Methionine synthase FOC09_18340 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC09_18460 ENOG4105C0D helicase FOC09_18490 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_18495 ENOG4105CJ1 ABC, transporter FOC09_18530 ENOG41080TC multidrug resistance protein FOC09_18550 ENOG4105WZW rhodanese family FOC09_18555 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC09_18575 ENOG4107YBY Hydrolase FOC09_18585 ENOG4105CBJ Metal-dependent enzyme FOC09_18600 ENOG4105DC7 peptidase M24 FOC09_18625 ENOG4105CD2 stage iii sporulation protein aa FOC09_18630 ENOG4105KR5 Stage iii sporulation protein FOC09_18635 ENOG4108CQH stage III sporulation protein AC FOC09_18640 ENOG4105KQ4 Stage iii sporulation protein ad FOC09_18650 ENOG410644B Stage III sporulation protein af FOC09_18675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC09_18680 ENOG4108ZSR alkaline shock protein FOC09_18705 ENOG4105CTB Polyprenyl synthetase FOC09_18715 ENOG4105DX0 Hemolysin A FOC09_18725 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC09_18730 ENOG4105S1Z Stage IV sporulation protein B FOC09_18735 ENOG4107QQR Sporulation FOC09_18750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC09_18760 ENOG4108JUB Transcriptional regulator FOC09_18770 ENOG4107RDP Dehydrogenase FOC09_18790 ENOG4105CPP Dehydrogenase, E1 component FOC09_18795 ENOG4105C7S Dehydrogenase FOC09_18810 ENOG4105G7B Protein of unknown function (DUF2992) FOC09_18820 ENOG4108HW3 (ABC) transporter FOC09_18825 ENOG4105E5Q amino acid AbC transporter FOC09_18830 ENOG4105CDA abc transporter atp-binding protein FOC09_18835 ENOG4108QEG Membrane FOC09_18840 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC09_18855 ENOG4105D9U N-acetyltransferase FOC09_18860 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC09_18870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC09_18895 ENOG4105EJQ L-serine dehydratase FOC09_18900 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_18910 ENOG4108IXY short-chain dehydrogenase reductase FOC09_18925 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC09_18965 ENOG4105CGH 5'-nucleotidase FOC09_18970 ENOG4105DFD Na H antiporter FOC09_18980 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC09_18990 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC09_18995 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_19000 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC09_19005 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC09_19025 ENOG4108R6K riboflavin synthase, subunit alpha FOC09_19030 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC09_19050 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC09_19055 ENOG4105ETE Transcriptional regulator (LacI family FOC09_19065 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC09_19085 ENOG4105RHY Pfam:UPF0157 FOC09_19095 ENOG4105CPC Aldo Keto reductase FOC09_19115 ENOG4105MZ9 stage II sporulation protein m FOC09_19120 ENOG4105I3K Ferric uptake regulator, Fur family FOC09_19130 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC09_19155 ENOG4105D7N magnesium and cobalt transport protein CorA FOC09_19185 ENOG4105DVE abc transporter atp-binding protein FOC09_19190 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_19195 ENOG4105DZ1 carboxypeptidase FOC09_19200 ENOG41082AN stage II sporulation protein FOC09_19210 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_19215 ENOG4105C8J )-transporter FOC09_19235 ENOG41090VF Stage v sporulation protein ac FOC09_19240 ENOG4105CZ3 stage V sporulation protein ad FOC09_19250 ENOG4105G6R Stage v sporulation protein ae FOC09_19260 ENOG4105J7I hydrolase FOC09_19265 ENOG4105PTM secreted protein FOC09_19270 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC09_19305 ENOG4105CE4 GlcNAc 6-P deacetylase FOC09_19315 ENOG4105FDP GntR family transcriptional regulator FOC09_19325 ENOG4105CID antiterminator FOC09_19340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC09_19360 ENOG4106TD9 Diguanylate cyclase FOC09_19380 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC09_19405 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC09_19415 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC09_19425 ENOG4105DTD Dehydrogenase FOC09_19430 ENOG4105K7K Transcriptional regulator FOC09_19470 ENOG4105CHU acetyl-coa acetyltransferase FOC09_19515 ENOG4105CG3 alpha amylase, catalytic region FOC09_19525 ENOG4107FKK extracellular solute-binding protein family 1 FOC09_19535 ENOG4105EG2 ABC transporter, permease FOC09_19540 ENOG4105FKQ transcriptional regulator FOC09_19545 ENOG4105CHM Aminotransferase FOC09_19555 ENOG4108HGU Histidine kinase FOC09_19610 ENOG4105UIN FOC09_19620 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC09_19635 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC09_19640 ENOG4105EPM Diguanylate phosphodiesterase FOC09_19655 ENOG4107IN1 Protein of unknown function (DUF1797) FOC09_19660 ENOG4108XRC Protein of unknown function (DUF458) FOC09_19695 ENOG4107ZYR domain protein FOC09_19700 ENOG4105CN5 Metallo-Beta-Lactamase FOC09_19710 ENOG4108X4Q Hydrolase FOC09_19715 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC09_19730 ENOG4105CPP Dehydrogenase, E1 component FOC09_19735 ENOG4105C7S Dehydrogenase FOC09_19780 ENOG4105CXN decarboxylase FOC09_19800 ENOG4105ECY inositol monophosphatase FOC09_19810 ENOG4105CI3 gtp-binding protein typa FOC09_19815 ENOG4105QA2 FOC09_19835 ENOG4108IAB Phoh family FOC09_19850 ENOG4105CNI cell division protein FtsW FOC09_19855 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC09_19905 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC09_19920 ENOG4107TB6 phosphoglycerate mutase FOC09_19940 ENOG4106H78 methyltransferase FOC09_19950 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC09_19955 ENOG4105D78 K07001 NTE family protein FOC09_19960 ENOG41063PX domain protein FOC09_19970 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC09_19990 ENOG4108IMY Transcriptional regulator FOC09_20035 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_20050 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC09_20135 ENOG4105CAR Terminase, large subunit FOC09_20145 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC09_20225 ENOG4105XSJ toxin secretion phage lysis holin FOC09_20275 ENOG4105KNH Nucleic acid-binding protein FOC09_20315 ENOG41068DC Essential cell division protein (By similarity) FOC09_20320 ENOG4105CJN penicillin-binding protein FOC09_20325 ENOG4105CJN penicillin-binding protein FOC09_20330 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC09_20345 ENOG4105CNI cell division protein FtsW FOC09_20350 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC09_20355 ENOG4105D4A Cell wall formation (By similarity) FOC09_20360 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC09_20365 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC09_20370 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC09_20380 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC09_20390 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC09_20395 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC09_20400 ENOG4105DFA alanine racemase domain protein FOC09_20410 ENOG41067XK integral membrane protein FOC09_20415 ENOG4105DBK s4 domain protein FOC09_20425 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC09_20440 ENOG4105C34 Pseudouridine synthase FOC09_20465 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC09_20520 ENOG4105DC7 peptidase M24 FOC09_20525 ENOG4105F23 Fibronectin-binding protein FOC09_20535 ENOG4105DSJ YicC domain protein FOC09_20555 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC09_20560 ENOG4105C25 Primosomal protein n' FOC09_20565 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC09_20575 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC09_20585 ENOG4108ZF3 Phosphatase FOC09_20590 ENOG4105D9P serine threonine protein kinase FOC09_20595 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC09_20600 ENOG4105DJV ribulose-phosphate 3-epimerase FOC09_20605 ENOG4105FJ0 thiamine FOC09_20620 ENOG4108ZAA Alkaline-shock protein FOC09_20625 ENOG4105DP4 dak2 domain fusion protein ylov FOC09_20630 ENOG4105CB5 ATP-dependent DNA helicase recG FOC09_20645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC09_20650 ENOG4105CHR reductase FOC09_20665 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC09_20670 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC09_20690 ENOG4105VB6 UPF0109 protein FOC09_20715 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC09_20730 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC09_20740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC09_20750 ENOG4108HE4 integrase family FOC09_20790 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC09_20795 ENOG4105KNE Phosphatidate cytidylyltransferase FOC09_20800 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC09_20805 ENOG4105DZP Membrane-associated zinc metalloprotease FOC09_20815 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC09_20825 ENOG4105CHV Transcription elongation factor NusA FOC09_20830 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC09_20835 ENOG4105VHM ribosomal protein FOC09_20845 ENOG4105W7A Protein of unknown function (DUF503) FOC09_20855 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC09_20860 ENOG4105DTN riboflavin biosynthesis protein ribF FOC09_20880 ENOG4105C1V Peptidase, M16 FOC09_20890 ENOG4105E35 Dipicolinate synthase subunit A FOC09_20895 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC09_20900 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC09_20910 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC09_20920 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC09_20930 ENOG4107QZI cell division protein FtsK FOC09_20935 ENOG4105FDP GntR family transcriptional regulator FOC09_20940 ENOG4105DIH basic membrane FOC09_20945 ENOG4108JQ9 ABC transporter FOC09_20970 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC09_20975 ENOG4105XZV Protein of unknown function (DUF3243) FOC09_20990 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC09_21015 ENOG4105D48 metallophosphoesterase FOC09_21020 ENOG4105MCT stage V sporulation protein S FOC09_21025 ENOG4108IGT Dipeptidase FOC09_21030 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC09_21035 ENOG4105DQU oxidoreductase, subunit beta FOC09_21040 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC09_21065 ENOG4105DA5 (ABC) transporter FOC09_21090 ENOG4107QHE Choloylglycine hydrolase FOC09_21100 ENOG410890F Dynamin family FOC09_21105 ENOG4105E0M Sulfatase FOC09_21110 ENOG4107R6R udp-galactopyranose mutase FOC09_21115 ENOG4105F0V Cell wall hydrolase FOC09_21140 ENOG4107YEI lmbE family FOC09_21145 ENOG4107TTQ Alpha beta hydrolase fold FOC09_21160 ENOG41067MG lrgb family FOC09_21180 ENOG4105BZU Histidine kinase FOC09_21185 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_21215 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC09_21220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC09_21230 ENOG4105CGK Exodeoxyribonuclease III FOC09_21250 ENOG4105E0A ABC, transporter FOC09_21255 ENOG4105NIV Esterase FOC09_21265 ENOG4105VPX protein, conserved in bacteria FOC09_21270 ENOG410681U heavy metal transport detoxification protein FOC09_21275 ENOG4105C59 p-type ATPase FOC09_21280 ENOG4105K70 DNA-binding protein FOC09_21285 ENOG4105TMB Formate nitrite transporter FOC09_21300 ENOG4105C85 amino acid FOC09_21310 ENOG4108SJC Membrane FOC09_21320 ENOG4105E98 transcriptional regulator DeoR family FOC09_21325 ENOG4105DE4 1-phosphofructokinase FOC09_21330 ENOG4105DM4 PTS System FOC09_21335 ENOG41069ER domain protein FOC09_21365 ENOG4106F1P AAA ATPase, central domain protein FOC09_21375 ENOG4105EN6 Membrane FOC09_21385 ENOG4105CXI aluminum resistance protein FOC09_21390 ENOG4105KV4 Transcriptional regulator FOC09_21395 ENOG4105C5F glutamine synthetase FOC09_21495 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC09_21680 ENOG4105XSJ toxin secretion phage lysis holin FOC09_21685 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC09_21720 ENOG4105K7K Transcriptional regulator FOC09_21740 ENOG4108SVB resolvase FOC09_21760 ENOG4105D5T phosphonate abc transporter FOC09_21775 ENOG4105D7V transposase FOC09_21795 ENOG4105BZ1 (ABC) transporter FOC09_21800 ENOG4105BZ1 (ABC) transporter FOC09_21815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC09_21840 ENOG41067MG lrgb family FOC09_21845 ENOG4105VAW lrga family FOC09_21850 ENOG4107RSM transcriptional regulator FOC09_21860 ENOG4107QIV Cytochrome c biogenesis protein FOC09_21915 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC09_21940 ENOG4108903 Formimidoylglutamase FOC09_21945 ENOG4108VJ1 Transcriptional regulator (CarD family FOC09_21950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC09_21955 ENOG4105CBC glutamate synthase FOC09_21960 ENOG4105CK7 Sodium proline symporter FOC09_21965 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC09_21970 ENOG4105FBA Phospholipase Carboxylesterase FOC09_21975 ENOG4105BZU Histidine kinase FOC09_21985 ENOG4107AYK membrAne FOC09_22035 ENOG4105CEY Amp-dependent synthetase and ligase FOC09_22040 ENOG4107ZYJ bioY protein FOC09_22045 ENOG4107F3J Amp-dependent synthetase and ligase FOC09_22065 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC09_22105 ENOG4108I0Z Aconitate hydratase FOC09_22110 ENOG4108JJA ABC, transporter FOC09_22120 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC09_22125 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC09_22155 ENOG4105W8X HesB YadR YfhF-family protein FOC09_22160 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC09_22165 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC09_22175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_22180 ENOG4105C0H protease FOC09_22185 ENOG4105K4P CoA-binding domain protein FOC09_22190 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC09_22200 ENOG4105D9R oxidoreductase FOC09_22210 ENOG4105CIG ABC transporter FOC09_22225 ENOG4105EMN RNA polymerase sigma factor FOC09_22235 ENOG4108KGH TRANSCRIPTIONal FOC09_22300 ENOG4105E1K spore germination protein FOC09_22305 ENOG4108JB9 formate dehydrogenase FOC09_22315 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC09_22320 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC09_22330 ENOG4105TMB Formate nitrite transporter FOC09_22335 ENOG4105D06 uba thif-type nad fad binding protein FOC09_22340 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC09_22345 ENOG4108ZAF Molybdopterin FOC09_22355 ENOG4105D1F ATP-binding protein FOC09_22370 ENOG410696E Membrane FOC09_22375 ENOG4105FR1 rard protein FOC09_22385 ENOG4105EWU Squalene--hopene cyclase FOC09_22395 ENOG4105CHR reductase FOC09_22400 ENOG4105C26 Dehydrogenase FOC09_22410 ENOG4108IA2 Sodium pantothenate symporter FOC09_22425 ENOG4106IQC argininosuccinate lyase FOC09_22435 ENOG410904N short-chain dehydrogenase reductase FOC09_22455 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC09_22475 ENOG4105VEQ Cold shock protein FOC09_22495 ENOG4108R1P FOC09_22505 ENOG41073R8 VanW family FOC09_22510 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_22525 ENOG4105KT7 mgtC SapB transporter FOC09_22535 ENOG4105E39 Enoyl-CoA hydratase FOC09_22540 ENOG4105K64 Glycosyl transferase, family 2 FOC09_22550 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC09_22570 ENOG4105CQB FAD linked oxidase domain protein FOC09_22575 ENOG4105C09 Bile acid FOC09_22585 ENOG4105RHY Pfam:UPF0157 FOC09_22610 ENOG4105CIS alcohol dehydrogenase FOC09_22615 ENOG41082BM Transcriptional regulator, arsr family FOC09_22640 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC09_22670 ENOG4108A04 Beta-lactamase FOC09_22675 ENOG4105DPN Oligoendopeptidase f FOC09_22685 ENOG4105E5K Alpha-amylase FOC09_22695 ENOG4105C98 muts2 protein FOC09_22715 ENOG4107V2S Transcriptional regulator FOC09_22725 ENOG4107CUJ Protein of unknown function (DUF2690) FOC09_22745 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC09_22750 ENOG4105NX3 Membrane FOC09_22755 ENOG4105DQ5 transport system permease protein FOC09_22760 ENOG4105EHG Permease protein FOC09_22765 ENOG4108MES Periplasmic binding protein FOC09_22785 ENOG4107R3E Citrate transporter FOC09_22795 ENOG4108TN2 lmbE family FOC09_22865 ENOG4105H3G oxidoreductase FOC09_22875 ENOG4105ED2 Beta-lactamase FOC09_22900 ENOG4107YXZ hydrolase, family 25 FOC09_22915 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC09_22940 ENOG4105KAF membrAne FOC09_23010 ENOG4105KVH Transcriptional regulator FOC09_23030 ENOG4105CHR reductase FOC09_23040 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC09_23075 ENOG4105KVH Transcriptional regulator FOC09_23080 ENOG4105KVH Transcriptional regulator FOC09_23085 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC09_23095 ENOG4108TZY GntR Family Transcriptional Regulator FOC09_23100 ENOG4105KVH Transcriptional regulator FOC09_23130 ENOG4105C44 Serine transporter FOC09_23135 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC09_23150 ENOG4105F27 Major Facilitator FOC09_23155 ENOG4105CV8 reductase FOC09_23175 ENOG4105D4Y metalloprotease FOC09_23180 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC09_23195 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC09_23200 ENOG4105CIS alcohol dehydrogenase FOC09_23205 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC09_23210 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC09_23225 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC09_23230 ENOG4105C6Z Gluconate FOC09_23235 ENOG4105CMG Carbohydrate kinase FOC09_23240 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC09_23245 ENOG4105XDF Protein of unknown function (DUF1272) FOC09_23250 ENOG4105DDN Pentapeptide repeat-containing protein FOC09_23265 ENOG4105C37 (CBS) domain FOC09_23295 ENOG4105EV4 Multidrug resistance protein mdtH FOC09_23305 ENOG4105DMQ Methyltransferase FOC09_23325 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC09_23330 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC09_23335 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC09_23345 ENOG4108UW5 maltose o-acetyltransferase FOC09_23350 ENOG4106UW1 Major Facilitator superfamily FOC09_23355 ENOG4105DKQ ROK family FOC09_23360 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_23420 ENOG4105CJ1 ABC, transporter FOC09_23430 ENOG4108PSK reductase FOC09_23450 ENOG4108RCM Nitroreductase FOC09_23455 ENOG4105KVH Transcriptional regulator FOC09_23470 ENOG4105CUT histidyl-tRNA synthetase FOC09_23475 ENOG4108Z66 YbaK ebsC protein FOC09_23485 ENOG41067QW Transcriptional regulator FOC09_23500 ENOG4108K8S endonuclease I FOC09_23525 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC09_23530 ENOG4108JJB ABC transporter FOC09_23560 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC09_23570 ENOG4105CRW Short chain fatty acid transporter FOC09_23580 ENOG4105KBX Transcriptional regulator, TetR family FOC09_23585 ENOG4105KPY Small multidrug resistance protein FOC09_23590 ENOG4105RXJ FOC09_23600 ENOG41069JR FOC09_23605 ENOG4105DA5 (ABC) transporter FOC09_23625 ENOG4105CZM Major Facilitator FOC09_23630 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC09_23640 ENOG4108ISG Major Facilitator FOC09_23690 ENOG410874W AraC family transcriptional regulator FOC09_23695 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC09_23710 ENOG4108AEY RNA polymerase sigma factor FOC09_23730 ENOG4108JQ1 Dehydrogenase FOC09_23745 ENOG4105DVH amino acid FOC09_23755 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC09_23770 ENOG4108JPW Aminotransferase FOC09_23785 ENOG4105EJQ L-serine dehydratase FOC09_23790 ENOG4105C44 Serine transporter FOC09_23805 ENOG4108JGH Tetr family transcriptional regulator FOC09_23810 ENOG4105EQ0 Major Facilitator superfamily FOC09_23830 ENOG4107QJQ Mate efflux family protein FOC09_23860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC09_23890 ENOG4105TRI Hydrolase FOC09_23925 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC09_23935 ENOG4106P55 Transcriptional regulator FOC09_23945 ENOG4107QR9 Iron-sulfur cluster binding protein FOC09_23950 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC09_23955 ENOG4105DJB Major Facilitator Superfamily FOC09_23960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC09_23975 ENOG4108U05 Transcriptional regulator FOC09_23990 ENOG4105BZU Histidine kinase FOC09_24005 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC09_24010 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC09_24025 ENOG4105JQZ Methyltransferase FOC09_24030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC09_24040 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC09_24045 ENOG4108NNI Beta-lactamase domain-containing protein FOC09_24060 ENOG4105VZ8 Transcriptional regulator FOC09_24080 ENOG4105K6H D-cysteine desulfhydrase FOC09_24105 ENOG41062D9 Histidine kinase FOC09_24110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC09_24125 ENOG4105IIP Membrane FOC09_24135 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC09_24140 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC09_24215 ENOG4108YXU transcriptional regulator AsnC family FOC09_24220 ENOG4105CHR reductase FOC09_24230 ENOG4105F7F Chaperone FOC09_24245 ENOG41085FC arsR family transcriptional regulator FOC09_24250 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC09_24255 ENOG4105D6J arsenicaL-resistance protein FOC09_24285 ENOG4105DIK (ABC) transporter FOC09_24290 ENOG4105CC5 ABC transporter FOC09_24295 ENOG4105DSE periplasmic solute binding protein FOC09_24300 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC09_24305 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC09_24320 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC09_24325 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC09_24340 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC09_24345 ENOG4108606 TspO/MBR family FOC09_24380 ENOG41090MY MarR family Transcriptional regulator FOC09_24405 ENOG4105CHJ isochorismatase hydrolase FOC09_24415 ENOG4105CH6 catalase FOC09_24420 ENOG4105CGH 5'-nucleotidase FOC09_24455 ENOG4105CSV Glutaminase FOC09_24490 ENOG4105C6K Malic enzyme FOC09_24500 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_24510 ENOG4105CUB amino acid FOC09_24515 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC09_24525 ENOG4108IMY Transcriptional regulator FOC09_24530 ENOG4105HDK L-asparaginase FOC09_24535 ENOG4108IJ0 Aspartate ammonia-lyase FOC09_24550 ENOG4105E2A Dehydrogenase FOC09_24610 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC09_24640 ENOG4105DWD nucleoside recognition domain protein FOC09_24660 ENOG4105FDT acyl-CoA dehydrogenase FOC09_24670 ENOG4108ZHR arsR family transcriptional regulator FOC09_24675 ENOG4108ZRV stage ii sporulation protein p FOC09_24680 ENOG4106N3A copper homeostasis protein cutc FOC09_24690 ENOG4107258 Transcriptional regulator FOC09_24695 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC09_24730 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC09_24775 ENOG4105F1N DNA alkylation repair FOC09_24785 ENOG4108IQI permease FOC09_24790 ENOG4105KNA -acetyltransferase FOC09_24795 ENOG410635A Membrane FOC09_24875 ENOG4108XET gCN5-related N-acetyltransferase FOC09_24905 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC09_24915 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC09_24950 ENOG4105FS7 Transcriptional regulator FOC09_24955 ENOG4108TVJ Nitroreductase FOC09_24965 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_25005 ENOG4105C8Y Acetylornithine aminotransferase FOC09_25015 ENOG4105CKK Glycosyl transferase, family 2 FOC09_25040 ENOG4105CKK Glycosyl transferase, family 2 FOC09_25065 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC09_25090 ENOG41068WN FOC09_25100 ENOG4108WCX response regulator FOC09_25110 ENOG41090T1 Membrane FOC09_25125 ENOG4105VMP Transcriptional regulator FOC09_25135 ENOG4105G6Z alkaline phosphatase FOC09_25140 ENOG4105ECK Fatty Acid Desaturase FOC09_25145 ENOG4105E0Y RtcB Protein FOC09_25155 ENOG4107258 Transcriptional regulator FOC09_25165 ENOG4105II7 pyrroline-5-carboxylate reductase FOC09_25170 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC09_25200 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC09_25220 ENOG41061GT Aldolase FOC09_25235 ENOG4105DKT Transcriptional regulator FOC09_25245 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC09_25255 ENOG4105D4B ABC, transporter FOC09_25280 ENOG4105EMN RNA polymerase sigma factor FOC09_25290 ENOG41069ER domain protein FOC09_25325 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC09_25330 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC09_25335 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC09_25355 ENOG41082JN Transcriptional regulator FOC09_25360 ENOG4105EYF MMPL domain protein FOC09_25365 ENOG4105EYF MMPL domain protein FOC09_25370 ENOG4105EYF MMPL domain protein FOC09_25380 ENOG4105C5H ABC transporter FOC09_25385 ENOG4105E0M Sulfatase FOC09_25390 ENOG4108ZCF integral membrane protein FOC09_25400 ENOG4107VMI polysaccharide deacetylase FOC09_25410 ENOG4107VC0 DNA alkylation repair enzyme FOC09_25460 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC09_25480 ENOG4105E09 nadh pyrophosphatase FOC09_25505 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC09_25510 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC09_25515 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC09_25525 ENOG4105C02 permease FOC09_25595 ENOG4105CHM Aminotransferase FOC09_25630 ENOG41089UC methyltransferase, type 11 FOC09_25645 ENOG4107BMA Transglycosylase associated protein FOC09_25665 ENOG4106K7D Major facilitator family transporter FOC09_25670 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC09_25710 ENOG4105EPR degv family FOC09_25725 ENOG4105DPN Oligoendopeptidase f FOC09_25765 ENOG4105BZU Histidine kinase FOC09_25770 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC09_25815 ENOG4105DTQ mandelate racemase muconate lactonizing FOC09_25830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC09_25835 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC09_25850 ENOG4107T5V SNARE associated Golgi FOC09_25890 ENOG41080HI glycine oxidase FOC09_25895 ENOG4105CTU Proline racemase FOC09_25900 ENOG4105CTU Proline racemase FOC09_25905 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC09_25910 ENOG4105C26 Dehydrogenase FOC09_25915 ENOG4105BZG amino acid carrier protein FOC09_25935 ENOG4108M1A Chitin-binding protein FOC09_25980 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC09_26000 ENOG4105EEM helicase FOC09_26050 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC09_26085 ENOG4108M1A Chitin-binding protein FOC09_26090 ENOG41082BV acetyltransferase FOC09_26095 ENOG4105E66 phosphoriboisomerase A FOC09_26120 ENOG4108IJ7 Glycine betaine FOC09_26125 ENOG4107SQ8 Glycine betaine FOC09_26155 ENOG4105RHY Pfam:UPF0157 FOC09_26160 ENOG4105E1F short-chain dehydrogenase reductase FOC09_26170 ENOG4107RUY (E1 component), alpha subunit FOC09_26180 ENOG4107QKR Dehydrogenase FOC09_26200 ENOG41062ES Transcriptional regulator FOC09_26220 ENOG4105E98 transcriptional regulator DeoR family FOC09_26235 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC09_26265 ENOG4107Z3H Transcriptional regulator, TetR family FOC09_26270 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC09_26275 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC09_26280 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC09_26300 ENOG4105MSI germination protein ypeb FOC09_26320 ENOG4108V3A UPF0421 protein FOC09_26355 ENOG4105FDR Membrane FOC09_26365 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC09_26390 ENOG4108IUM Glycogen debranching enzyme FOC09_26405 ENOG4105DY8 decarboxylase FOC09_26425 ENOG4105PAD Hydrolase FOC09_26450 ENOG4107VFR oxidoreductase FOC09_26490 ENOG4105PKS Excinuclease abc c subunit domain protein FOC09_26525 ENOG4105KWG Pfam:DUF1696 FOC09_26555 ENOG4108XI2 Domain of unknown function (DUF1963) FOC09_26590 ENOG4108Z4K mutator MutT protein FOC09_26595 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC09_26600 ENOG4105E09 nadh pyrophosphatase FOC09_26615 ENOG4105FCD Major Facilitator FOC09_26645 ENOG4107Y9U Membrane FOC09_26665 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC09_26680 ENOG4107Y80 Major Facilitator superfamily FOC09_26710 ENOG4108V4B ThiJ pfpI FOC09_26745 ENOG4105FQP Beta-lactamase FOC09_26755 ENOG4105CJN penicillin-binding protein FOC09_26760 ENOG4105CB2 alcohol dehydrogenase FOC09_26775 ENOG4108HGU Histidine kinase FOC09_26790 ENOG4108JJB ABC transporter FOC09_26810 ENOG4107RF6 penicillin-binding protein FOC09_26815 ENOG4105BZU Histidine kinase FOC09_26825 ENOG410667J hydrolase FOC09_26925 ENOG4105ETU transcriptional activator (TenA FOC09_27030 ENOG4105CPQ Dehydrogenase FOC09_27065 ENOG4105CUV Homoserine Kinase FOC09_27080 ENOG4107Y80 Major Facilitator superfamily FOC09_27090 ENOG4105FQP Beta-lactamase FOC09_27105 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC09_27105 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)