locus-tag class description FOC12_00030 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC12_00060 ENOG4105DWD nucleoside recognition domain protein FOC12_00075 ENOG4105FDT acyl-CoA dehydrogenase FOC12_00085 ENOG4108ZHR arsR family transcriptional regulator FOC12_00090 ENOG4108ZRV stage ii sporulation protein p FOC12_00095 ENOG4106N3A copper homeostasis protein cutc FOC12_00105 ENOG4107258 Transcriptional regulator FOC12_00110 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC12_00145 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC12_00190 ENOG4105F1N DNA alkylation repair FOC12_00200 ENOG4108IQI permease FOC12_00205 ENOG4105KNA -acetyltransferase FOC12_00210 ENOG410635A Membrane FOC12_00290 ENOG4108XET gCN5-related N-acetyltransferase FOC12_00320 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC12_00330 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_00365 ENOG4105FS7 Transcriptional regulator FOC12_00370 ENOG4108TVJ Nitroreductase FOC12_00380 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_00420 ENOG4105C8Y Acetylornithine aminotransferase FOC12_00430 ENOG4105CKK Glycosyl transferase, family 2 FOC12_00455 ENOG4105CKK Glycosyl transferase, family 2 FOC12_00480 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_00505 ENOG41068WN FOC12_00515 ENOG4108WCX response regulator FOC12_00525 ENOG41090T1 Membrane FOC12_00540 ENOG4105VMP Transcriptional regulator FOC12_00550 ENOG4105G6Z alkaline phosphatase FOC12_00555 ENOG4105ECK Fatty Acid Desaturase FOC12_00560 ENOG4105E0Y RtcB Protein FOC12_00570 ENOG4107258 Transcriptional regulator FOC12_00580 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_00585 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC12_00615 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC12_00635 ENOG41061GT Aldolase FOC12_00650 ENOG4105DKT Transcriptional regulator FOC12_00660 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC12_00670 ENOG4105D4B ABC, transporter FOC12_00695 ENOG4105EMN RNA polymerase sigma factor FOC12_00705 ENOG41069ER domain protein FOC12_00740 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC12_00745 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC12_00750 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC12_00770 ENOG41082JN Transcriptional regulator FOC12_00775 ENOG4105EYF MMPL domain protein FOC12_00780 ENOG4105EYF MMPL domain protein FOC12_00785 ENOG4105EYF MMPL domain protein FOC12_00795 ENOG4105C5H ABC transporter FOC12_00800 ENOG4105E0M Sulfatase FOC12_00805 ENOG4108ZCF integral membrane protein FOC12_00815 ENOG4107VMI polysaccharide deacetylase FOC12_00825 ENOG4107VC0 DNA alkylation repair enzyme FOC12_00875 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC12_00895 ENOG4105E09 nadh pyrophosphatase FOC12_00920 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC12_00925 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC12_00930 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC12_00940 ENOG4105C02 permease FOC12_01010 ENOG4105CHM Aminotransferase FOC12_01045 ENOG41089UC methyltransferase, type 11 FOC12_01060 ENOG4107BMA Transglycosylase associated protein FOC12_01080 ENOG4106K7D Major facilitator family transporter FOC12_01085 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC12_01125 ENOG4105EPR degv family FOC12_01140 ENOG4105DPN Oligoendopeptidase f FOC12_01180 ENOG4105BZU Histidine kinase FOC12_01185 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC12_01230 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_01245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC12_01250 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC12_01265 ENOG4107T5V SNARE associated Golgi FOC12_01305 ENOG41080HI glycine oxidase FOC12_01310 ENOG4105CTU Proline racemase FOC12_01315 ENOG4105CTU Proline racemase FOC12_01320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC12_01325 ENOG4105C26 Dehydrogenase FOC12_01330 ENOG4105BZG amino acid carrier protein FOC12_01350 ENOG4108M1A Chitin-binding protein FOC12_01395 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC12_01415 ENOG4105EEM helicase FOC12_01465 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC12_01500 ENOG4108M1A Chitin-binding protein FOC12_01505 ENOG41082BV acetyltransferase FOC12_01510 ENOG4105E66 phosphoriboisomerase A FOC12_01535 ENOG4108IJ7 Glycine betaine FOC12_01540 ENOG4107SQ8 Glycine betaine FOC12_01570 ENOG4105RHY Pfam:UPF0157 FOC12_01575 ENOG4105E1F short-chain dehydrogenase reductase FOC12_01585 ENOG4107RUY (E1 component), alpha subunit FOC12_01595 ENOG4107QKR Dehydrogenase FOC12_01615 ENOG41062ES Transcriptional regulator FOC12_01635 ENOG4105E98 transcriptional regulator DeoR family FOC12_01650 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC12_01680 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_01685 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC12_01690 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC12_01695 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC12_01715 ENOG4105MSI germination protein ypeb FOC12_01735 ENOG4108V3A UPF0421 protein FOC12_01770 ENOG4105FDR Membrane FOC12_01780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC12_01805 ENOG4108IUM Glycogen debranching enzyme FOC12_01820 ENOG4105DY8 decarboxylase FOC12_01840 ENOG4105PAD Hydrolase FOC12_01865 ENOG4107VFR oxidoreductase FOC12_01905 ENOG4105PKS Excinuclease abc c subunit domain protein FOC12_01940 ENOG4105KWG Pfam:DUF1696 FOC12_01970 ENOG4108XI2 Domain of unknown function (DUF1963) FOC12_02005 ENOG4108Z4K mutator MutT protein FOC12_02010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC12_02015 ENOG4105E09 nadh pyrophosphatase FOC12_02030 ENOG4105FCD Major Facilitator FOC12_02060 ENOG4107Y9U Membrane FOC12_02080 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC12_02095 ENOG4107Y80 Major Facilitator superfamily FOC12_02125 ENOG4108V4B ThiJ pfpI FOC12_02160 ENOG4105FQP Beta-lactamase FOC12_02170 ENOG4105CJN penicillin-binding protein FOC12_02175 ENOG4105CB2 alcohol dehydrogenase FOC12_02190 ENOG4108HGU Histidine kinase FOC12_02205 ENOG4108JJB ABC transporter FOC12_02225 ENOG4107RF6 penicillin-binding protein FOC12_02230 ENOG4105BZU Histidine kinase FOC12_02240 ENOG410667J hydrolase FOC12_02340 ENOG4105ETU transcriptional activator (TenA FOC12_02445 ENOG4105CPQ Dehydrogenase FOC12_02480 ENOG4105CUV Homoserine Kinase FOC12_02495 ENOG4107Y80 Major Facilitator superfamily FOC12_02505 ENOG4105FQP Beta-lactamase FOC12_02520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_02520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_02560 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC12_02570 ENOG4105T9C HD domain FOC12_02585 ENOG4105DZ1 carboxypeptidase FOC12_02600 ENOG4105DBI uridine monophosphokinase FOC12_02605 ENOG4105WCN acetyltransferase FOC12_02615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC12_02620 ENOG4107QX3 carboxylase FOC12_02625 ENOG4105E39 Enoyl-CoA hydratase FOC12_02630 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC12_02635 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC12_02640 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC12_02645 ENOG4105C1G acyl-Coa dehydrogenase FOC12_02660 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_02670 ENOG4105CJ1 ABC, transporter FOC12_02685 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC12_02690 ENOG4105CEP NADH dehydrogenase FOC12_02695 ENOG4106ANW SMI1_KNR4 FOC12_02710 ENOG4105BZU Histidine kinase FOC12_02720 ENOG4105C5H ABC transporter FOC12_02725 ENOG41067SE Tetr family transcriptional regulator FOC12_02745 ENOG4108VXD carboxy-peptidase FOC12_02760 ENOG4105VZ8 Transcriptional regulator FOC12_02790 ENOG4105DH8 myo-inositol catabolism FOC12_02795 ENOG4105D2N Aldolase FOC12_02820 ENOG4105CK5 oxidoreductase FOC12_02825 ENOG4105IE8 Alpha-ketoglutarate permease FOC12_02830 ENOG4105ETE Transcriptional regulator (LacI family FOC12_02835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC12_02850 ENOG4107RF6 penicillin-binding protein FOC12_02875 ENOG4105CIN aminoacyl-histidine dipeptidase FOC12_02905 ENOG41090HR transcriptional regulator FOC12_02910 ENOG4107RA9 decarboxylase FOC12_02915 ENOG4108I0C methyltransferase FOC12_02925 ENOG41088CC tellurite resistance protein tehB FOC12_02945 ENOG4108RZE Tetr family transcriptional regulator FOC12_02960 ENOG4105C1J atp-dependent rna helicase FOC12_02975 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC12_02995 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC12_03005 ENOG4105RD7 BadF BadG BcrA BcrD FOC12_03055 ENOG4108KPJ rna polymerase sigma factor FOC12_03085 ENOG4108JCI Transcriptional regulator FOC12_03105 ENOG4105BZ1 (ABC) transporter FOC12_03110 ENOG4105BZ1 (ABC) transporter FOC12_03125 ENOG4108RPX mosc domain containing protein FOC12_03130 ENOG4105DND Transcriptional regulator FOC12_03145 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC12_03150 ENOG4107V2S Transcriptional regulator FOC12_03190 ENOG410667J hydrolase FOC12_03210 ENOG4105VEQ Cold shock protein FOC12_03220 ENOG41068WN FOC12_03230 ENOG4105C1Q protoporphyrinogen oxidase FOC12_03260 ENOG4105WCN acetyltransferase FOC12_03285 ENOG4105EYF MMPL domain protein FOC12_03295 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC12_03310 ENOG41081I9 integral membrane protein FOC12_03340 ENOG4108D32 Methyltransferase FOC12_03365 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC12_03380 ENOG4105C22 threonyL-tRNA synthetase FOC12_03385 ENOG4105FE9 pseudouridine synthase FOC12_03405 ENOG4105BZG amino acid carrier protein FOC12_03425 ENOG4105K70 DNA-binding protein FOC12_03440 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_03445 ENOG4105WQT MbtH domain protein FOC12_03450 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_03455 ENOG4105WQI isochorismatase FOC12_03460 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC12_03465 ENOG4105E4F Isochorismate synthase FOC12_03470 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC12_03475 ENOG4105FCD Major Facilitator FOC12_03495 ENOG4105EYH Exonuclease FOC12_03500 ENOG4107RFY SbcCD D subunit FOC12_03515 ENOG4105E39 Enoyl-CoA hydratase FOC12_03520 ENOG4105N14 lysine exporter protein LysE YggA FOC12_03530 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC12_03535 ENOG4105C1G acyl-Coa dehydrogenase FOC12_03540 ENOG4105CR4 methylisocitrate lyase FOC12_03545 ENOG4105DXD 2-methylcitrate dehydratase FOC12_03555 ENOG4105W8X HesB YadR YfhF-family protein FOC12_03560 ENOG4105CZM Major Facilitator FOC12_03565 ENOG4105BZ4 penicillin-binding protein FOC12_03605 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_03710 ENOG4108IBT Inherit from COG: transposase FOC12_03725 ENOG4105SZ6 Thioredoxin FOC12_03735 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC12_03740 ENOG4108N23 SpoOM-related protein FOC12_03780 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC12_03785 ENOG4108JUB Transcriptional regulator FOC12_03790 ENOG4108TSC N-acetyltransferase FOC12_03795 ENOG4107S4Y M20 DapE family protein YgeY FOC12_03810 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_03835 ENOG4105C37 (CBS) domain FOC12_03870 ENOG4105E90 ABC transporter FOC12_03875 ENOG4108IJ8 ABC transporter FOC12_03900 ENOG4105CMG Carbohydrate kinase FOC12_03905 ENOG4105CMG Carbohydrate kinase FOC12_03940 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_03945 ENOG4105BZU Histidine kinase FOC12_03950 ENOG4105D8X mechanosensitive ion channel FOC12_03985 ENOG4105F0I Aminotransferase FOC12_03990 ENOG4108MES Periplasmic binding protein FOC12_04005 ENOG4105CAQ asparagine synthetase FOC12_04010 ENOG4107Y70 Heat shock protein FOC12_04015 ENOG4108KF3 Electron transport protein SCO1 SenC FOC12_04020 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC12_04025 ENOG4108RCR degv family FOC12_04035 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC12_04045 ENOG4108UT2 hemolysin iii FOC12_04050 ENOG4105E9Q Acyl-transferase FOC12_04055 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC12_04060 ENOG4107RVG penicillin-binding protein FOC12_04075 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC12_04095 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC12_04125 ENOG4105KD7 acetyltransferase FOC12_04140 ENOG4105C0A alcohol dehydrogenase FOC12_04145 ENOG4105CY2 Citrate transporter FOC12_04150 ENOG4107XGZ Hydrolase FOC12_04170 ENOG4105C8J )-transporter FOC12_04185 ENOG41062D9 Histidine kinase FOC12_04190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_04195 ENOG4107QPK )-transporter FOC12_04200 ENOG4105BZW Glycerate kinase FOC12_04270 ENOG4105EC2 ftsk spoIIIe FOC12_04290 ENOG4105C5S asparaginyl-tRNA synthetase FOC12_04310 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC12_04335 ENOG4105C75 arginyL-tRNA synthetase FOC12_04340 ENOG4107YX5 Pfam:DUF548 FOC12_04370 ENOG4108UUM single-stranded DNA-binding protein FOC12_04385 ENOG4105C5H ABC transporter FOC12_04405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC12_04420 ENOG4105MCT stage V sporulation protein S FOC12_04455 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC12_04460 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC12_04465 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC12_04470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC12_04475 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC12_04480 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC12_04505 ENOG4108ZAF Molybdopterin FOC12_04510 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_04515 ENOG4105D06 uba thif-type nad fad binding protein FOC12_04520 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC12_04525 ENOG4107V6Q Cyclic nucleotide-binding domain FOC12_04550 ENOG4105R3A Nitrate reductase FOC12_04555 ENOG4108IUE nitrate reductase beta subunit FOC12_04575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC12_04590 ENOG4108V06 Glutathione peroxidase FOC12_04615 ENOG4105EMN RNA polymerase sigma factor FOC12_04620 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC12_04630 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_04655 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC12_04680 ENOG4105KBJ sporulation protein ytfj FOC12_04730 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC12_04755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC12_04760 ENOG4108JYZ YitT family FOC12_04765 ENOG41087PP glycosyltransferase MGT family FOC12_04780 ENOG4107RBS Methyltransferase FOC12_04785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC12_04795 ENOG4108X4Q Hydrolase FOC12_04820 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC12_04830 ENOG4108VXD carboxy-peptidase FOC12_04840 ENOG4108ZRV stage ii sporulation protein p FOC12_04860 ENOG4108Z7R Chaperone CsaA FOC12_04880 ENOG4105C37 (CBS) domain FOC12_04885 ENOG4105SXS Protein of unknown function (DUF456) FOC12_04905 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_04915 ENOG4108S4H thioesterase Superfamily protein FOC12_04925 ENOG4108PJD permease FOC12_04940 ENOG4107T5V SNARE associated Golgi FOC12_04960 ENOG4105CVJ phosphoglycerate mutase FOC12_04985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC12_04995 ENOG4105K4T epimerase FOC12_05000 ENOG4105DSE periplasmic solute binding protein FOC12_05055 ENOG4105CKI cobalamin synthesis protein FOC12_05060 ENOG4107QM2 Aldo Keto reductase FOC12_05080 ENOG4105DEN Luciferase family FOC12_05095 ENOG4108WPJ Ferritin-like domain FOC12_05100 ENOG4108K88 Membrane FOC12_05115 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_05140 ENOG4107XZQ multidrug resistance protein FOC12_05145 ENOG4107SET aldo keto reductase FOC12_05150 ENOG4105YVS arsR family transcriptional regulator FOC12_05160 ENOG4105KRN Transcriptional regulator, abrb family FOC12_05210 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC12_05220 ENOG4105YWU small acid-soluble spore protein FOC12_05225 ENOG4108WBH protein TIM barrel FOC12_05240 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_05245 ENOG4105DUU IucA IucC family protein FOC12_05255 ENOG4105VRR gCN5-related N-acetyltransferase FOC12_05260 ENOG4105KT7 mgtC SapB transporter FOC12_05270 ENOG4107VMI polysaccharide deacetylase FOC12_05275 ENOG4105BZU Histidine kinase FOC12_05280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_05290 ENOG4108KGH TRANSCRIPTIONal FOC12_05315 ENOG4105D6E homoserine dehydrogenase FOC12_05335 ENOG4108ZJ4 polysaccharide deacetylase FOC12_05340 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC12_05360 ENOG4105BZU Histidine kinase FOC12_05365 ENOG4105EFI regulatoR FOC12_05415 ENOG4108JJ8 (ABC) transporter FOC12_05420 ENOG4108JJ9 ABC, transporter FOC12_05425 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC12_05430 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC12_05440 ENOG4105YGB Transcriptional regulator FOC12_05460 ENOG4105SKE transcriptional Regulator LysR family FOC12_05470 ENOG4105C32 Amino acid ABC transporter (Permease) FOC12_05475 ENOG4108IV0 ABC, transporter FOC12_05480 ENOG4105C0Z ABC transporter FOC12_05490 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_05495 ENOG4108Z7G MaoC domain protein dehydratase FOC12_05515 ENOG4105CKI cobalamin synthesis protein FOC12_05525 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_05530 ENOG4106F5Q Membrane FOC12_05535 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC12_05540 ENOG4108TVJ Nitroreductase FOC12_05545 ENOG4107ZXU DSBA oxidoreductase FOC12_05550 ENOG4108Z40 Transcriptional regulator FOC12_05555 ENOG4105GZI Transcriptional regulator FOC12_05560 ENOG4107RT3 EamA-like transporter family FOC12_05570 ENOG4105KTB nuclear export factor GLE1 FOC12_05575 ENOG4108T5E Copper resistance protein FOC12_05620 ENOG4107STQ Multicopper oxidase FOC12_05625 ENOG4107RAQ aminopeptidase FOC12_05660 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC12_05665 ENOG4105D9N nucleoside FOC12_05675 ENOG4107RHR regulatoR FOC12_05705 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC12_05715 ENOG4105C72 UPF0176 protein FOC12_05720 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC12_05740 ENOG41068WN FOC12_05775 ENOG4105F6J Alpha beta hydrolase fold FOC12_05795 ENOG4105CYC Transferase FOC12_05800 ENOG4105DY9 regulatoR FOC12_05810 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC12_05815 ENOG4105C6X Major Facilitator FOC12_05840 ENOG4105C7B Threonine dehydratase FOC12_05850 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC12_05855 ENOG4108ZP8 Acetolactate synthase small subunit FOC12_05860 ENOG4105C7K acetolactate synthase FOC12_05865 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC12_05870 ENOG4105CHR reductase FOC12_05875 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC12_05890 ENOG4106KE4 Dehydrogenase FOC12_05905 ENOG4105H67 Protein of unknown function (DUF421) FOC12_05910 ENOG4105X5K response regulator receiver protein FOC12_05920 ENOG4105C8J )-transporter FOC12_05940 ENOG4105C6T cysteine synthase FOC12_05945 ENOG4105EU0 Major facilitator Superfamily FOC12_05975 ENOG4105CSR polyphosphate kinase 2 FOC12_06015 ENOG4105FVX FOC12_06075 ENOG4105C6K Malic enzyme FOC12_06080 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_06090 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC12_06110 ENOG4105CJ1 ABC, transporter FOC12_06145 ENOG4106BRA Membrane FOC12_06175 ENOG4107QIV Cytochrome c biogenesis protein FOC12_06195 ENOG4105EC3 peptidase S51, dipeptidase E FOC12_06220 ENOG4105C9Q fumarate hydratase class II FOC12_06225 ENOG4105DFD Na H antiporter FOC12_06240 ENOG4108PJD permease FOC12_06245 ENOG4105CKI cobalamin synthesis protein FOC12_06250 ENOG4108UZ3 Transporter FOC12_06255 ENOG4105DRR Transcriptional regulator, GntR family FOC12_06265 ENOG4105PGM cation diffusion facilitator family transporter FOC12_06285 ENOG4105CAQ asparagine synthetase FOC12_06315 ENOG4105CVJ phosphoglycerate mutase FOC12_06355 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC12_06360 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC12_06365 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC12_06370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_06375 ENOG4105DUM transcriptional regulator, lysR family FOC12_06400 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC12_06420 ENOG4108RZE Tetr family transcriptional regulator FOC12_06445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_06450 ENOG4105KTQ flagellar basal-body rod protein FOC12_06460 ENOG4105D7B Flagellar biosynthesis protein flha FOC12_06465 ENOG4105D00 flagellar biosynthetic protein flhB FOC12_06475 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC12_06480 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC12_06490 ENOG4105DD5 Flagellar motor switch protein FOC12_06505 ENOG4105E4C Lytic transglycosylase catalytic FOC12_06510 ENOG4105I03 Flagellin FOC12_06545 ENOG4105K64 Glycosyl transferase, family 2 FOC12_06570 ENOG4105BZE flagellar hook protein, FlgE FOC12_06605 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC12_06615 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC12_06620 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC12_06625 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC12_06650 ENOG4105E1Q flagellar hook-associated protein FOC12_06670 ENOG4105BZU Histidine kinase FOC12_06685 ENOG4105DD5 Flagellar motor switch protein FOC12_06695 ENOG4107YTP response regulator receiver protein FOC12_06700 ENOG4105ER2 Ompa motb domain protein FOC12_06705 ENOG4107R0U MotA TolQ exbB proton channel FOC12_06715 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC12_06770 ENOG41080C8 DUF218 domain FOC12_06775 ENOG4105H67 Protein of unknown function (DUF421) FOC12_06785 ENOG4108Z5V transcriptional regulator, merr family FOC12_06795 ENOG4107RWR Sodium hydrogen exchanger FOC12_06805 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_06870 ENOG41081VK Ribonuclease FOC12_06890 ENOG4108SZE gCN5-related N-acetyltransferase FOC12_06990 ENOG4105KHC sulfurtransferase FOC12_07000 ENOG4108W0I acetyltransferase FOC12_07010 ENOG410890F Dynamin family FOC12_07020 ENOG4105DHF Membrane FOC12_07025 ENOG4105C2W permease FOC12_07040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_07055 ENOG4105CTD carboxy-peptidase FOC12_07060 ENOG4105DVT helicase FOC12_07070 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC12_07125 ENOG4105BZ4 penicillin-binding protein FOC12_07135 ENOG4105CSM endonuclease III FOC12_07155 ENOG4105YAC FOC12_07160 ENOG4105DVT helicase FOC12_07195 ENOG4105CPK Glycosyl transferase (Group 1 FOC12_07200 ENOG4105FJR Lmbe family FOC12_07215 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC12_07220 ENOG4108JYZ YitT family FOC12_07250 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC12_07255 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC12_07260 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC12_07275 ENOG41068YB TPR repeat-containing protein FOC12_07280 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC12_07300 ENOG4105EAH synthase FOC12_07310 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC12_07325 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC12_07355 ENOG41065D1 FOC12_07360 ENOG4105S2F FOC12_07395 ENOG4105HDK L-asparaginase FOC12_07400 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC12_07425 ENOG4108S6Z Negative regulator of genetic competence FOC12_07430 ENOG4107X2D transcriptional regulator, merr family FOC12_07445 ENOG4105I7S Abortive infection protein FOC12_07450 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC12_07455 ENOG4105T7X FOC12_07465 ENOG4108SAX Membrane FOC12_07480 ENOG4108WBT adenosyltransferase FOC12_07485 ENOG4105BZU Histidine kinase FOC12_07490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_07495 ENOG4105CRE cytochrome C FOC12_07500 ENOG4107TWT Cytochrome c biogenesis protein FOC12_07510 ENOG4105FE9 pseudouridine synthase FOC12_07520 ENOG4108JIC nucleoside recognition domain protein FOC12_07525 ENOG4105DZ1 carboxypeptidase FOC12_07530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_07565 ENOG4105BZU Histidine kinase FOC12_07580 ENOG4105I3N Conserved Protein FOC12_07600 ENOG4105BZ4 penicillin-binding protein FOC12_07605 ENOG4107GRR phosphate transport regulator FOC12_07610 ENOG4105CJ3 phosphate transporter FOC12_07630 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC12_07655 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC12_07675 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_07680 ENOG4105ENE Histidine kinase FOC12_07700 ENOG4105DFD Na H antiporter FOC12_07720 ENOG4105C8J )-transporter FOC12_07725 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC12_07730 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC12_07735 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC12_07745 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC12_07750 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC12_07770 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC12_07780 ENOG4105E0M Sulfatase FOC12_07785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC12_07800 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC12_07835 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC12_07860 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC12_07870 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC12_07875 ENOG4108ZP8 Acetolactate synthase small subunit FOC12_07880 ENOG4105C7K acetolactate synthase FOC12_07885 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC12_07910 ENOG4105KBJ sporulation protein ytfj FOC12_07915 ENOG41063Y9 FOC12_07920 ENOG4105CZN Potassium uptake protein FOC12_07950 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_07955 ENOG4107QMU Mate efflux family protein FOC12_07980 ENOG4105NQC Flavodoxin FOC12_08000 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_08010 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC12_08015 ENOG4105EA8 2-Nitropropane dioxygenase FOC12_08020 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC12_08060 ENOG4105CJ1 ABC, transporter FOC12_08070 ENOG4105CZV ABC transporter FOC12_08075 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC12_08080 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC12_08100 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC12_08135 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC12_08140 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC12_08150 ENOG4105BZU Histidine kinase FOC12_08155 ENOG4106DF1 FOC12_08165 ENOG41090MY MarR family Transcriptional regulator FOC12_08170 ENOG4105BZU Histidine kinase FOC12_08180 ENOG4105PXI polysaccharide deacetylase FOC12_08200 ENOG4105E98 transcriptional regulator DeoR family FOC12_08215 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC12_08230 ENOG4105C4Y ABC transporter FOC12_08245 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC12_08255 ENOG4105CHR reductase FOC12_08275 ENOG4108Z7G MaoC domain protein dehydratase FOC12_08280 ENOG410681C small acid-soluble spore protein FOC12_08285 ENOG4105CZN Potassium uptake protein FOC12_08290 ENOG4107TS3 membrane protein, TerC FOC12_08295 ENOG4108QTI )-transporter FOC12_08305 ENOG4106A3R peptidase FOC12_08325 ENOG4105JXH GntR family transcriptional regulator FOC12_08330 ENOG4105BZU Histidine kinase FOC12_08335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_08350 ENOG4105CQB FAD linked oxidase domain protein FOC12_08355 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC12_08360 ENOG4105K4I Scp-like extracellular FOC12_08370 ENOG4108YBP pseudouridine synthase FOC12_08380 ENOG4105EYF MMPL domain protein FOC12_08390 ENOG4107RUE extracellular solute-binding protein family 1 FOC12_08395 ENOG4105D38 putrescine abc transporter FOC12_08400 ENOG4105F38 ABC transporter, permease FOC12_08405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_08410 ENOG4105C26 Dehydrogenase FOC12_08445 ENOG4105VFR signal peptidase FOC12_08450 ENOG4105DZ1 carboxypeptidase FOC12_08460 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC12_08520 ENOG4105VZ8 Transcriptional regulator FOC12_08530 ENOG4105C7S Dehydrogenase FOC12_08625 ENOG4105DDQ anthranilate synthase FOC12_08635 ENOG4105CK7 Sodium proline symporter FOC12_08660 ENOG4108WVJ 2'-5' rna ligase FOC12_08710 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC12_08720 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC12_08725 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC12_08745 ENOG4107TVC Glycosyl transferase, family 2 FOC12_08765 ENOG4105K64 Glycosyl transferase, family 2 FOC12_08785 ENOG4105EMS pseudouridine synthase FOC12_08790 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC12_08805 ENOG4105MIX Adenylate cyclase FOC12_08810 ENOG4108Z18 K06886 hemoglobin FOC12_08820 ENOG4105DPN Oligoendopeptidase f FOC12_08830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_08840 ENOG4108ZCF integral membrane protein FOC12_08860 ENOG4105UQX Mate efflux family protein FOC12_08865 ENOG4108JQ7 (ABC) transporter FOC12_08875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_08880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_08895 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC12_08910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC12_08915 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_08940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC12_08950 ENOG4108KP7 hydrolase FOC12_08960 ENOG41073B9 FOC12_08965 ENOG4107AYK membrAne FOC12_08975 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_08985 ENOG4105QNR S1 RNA binding domain protein FOC12_09010 ENOG4105CH6 catalase FOC12_09015 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC12_09020 ENOG4105CAQ asparagine synthetase FOC12_09045 ENOG4105ERH Fumarylacetoacetate hydrolase FOC12_09090 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC12_09095 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC12_09110 ENOG4105XVF Competence transcription factor FOC12_09125 ENOG4105VEQ Cold shock protein FOC12_09140 ENOG4107QP3 malate synthase g FOC12_09145 ENOG4105ZU5 s-layer protein FOC12_09165 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_09170 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC12_09195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_09210 ENOG41086D8 Transcriptional regulator FOC12_09215 ENOG4108AEY RNA polymerase sigma factor FOC12_09225 ENOG4107TVP HD domain protein FOC12_09260 ENOG4105CNA YD repeat protein FOC12_09290 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_09300 ENOG4105DF9 Lipoate-protein, ligase FOC12_09305 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC12_09310 ENOG4106AXD FOC12_09340 ENOG4105ECB domain protein FOC12_09355 ENOG4105NA0 Transcriptional regulator FOC12_09380 ENOG4105C1Q protoporphyrinogen oxidase FOC12_09390 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC12_09395 ENOG4105BZ4 penicillin-binding protein FOC12_09400 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC12_09405 ENOG4105CKV Membrane FOC12_09410 ENOG410905X membrane-flanked domain protein FOC12_09455 ENOG410905X membrane-flanked domain protein FOC12_09485 ENOG4105K59 histidine triad (HIT) protein FOC12_09510 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC12_09515 ENOG4105EEM helicase FOC12_09525 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_09530 ENOG4105C57 major facilitator superfamily FOC12_09555 ENOG4105EMN RNA polymerase sigma factor FOC12_09565 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC12_09580 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC12_09600 ENOG4108MUZ hydrolase FOC12_09620 ENOG4105EQ0 Major Facilitator superfamily FOC12_09625 ENOG4108IND Tetr family transcriptional regulator FOC12_09640 ENOG4105D7V transposase FOC12_09650 ENOG4107VRP DNA repair exonuclease FOC12_09680 ENOG4105K8R UPF0145 protein FOC12_09700 ENOG4105BZU Histidine kinase FOC12_09705 ENOG4105BZU Histidine kinase FOC12_09710 ENOG4108MJI response regulator FOC12_09720 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_09730 ENOG4105WN5 stage II sporulation protein FOC12_09795 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC12_09825 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC12_09830 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC12_09835 ENOG4105CMT Dihydroxyacetone kinase FOC12_09845 ENOG4105CMT Dihydroxyacetone kinase FOC12_09865 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC12_09885 ENOG4108IG5 Transcriptional regulator FOC12_09890 ENOG4107P5I polyketide synthase FOC12_09935 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_09965 ENOG4105CDU Replicative dna helicase FOC12_10015 ENOG4108MRH transcriptional regulatory protein FOC12_10025 ENOG4105CSH Transporter FOC12_10055 ENOG4105PKS Excinuclease abc c subunit domain protein FOC12_10060 ENOG4108JQ7 (ABC) transporter FOC12_10070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_10110 ENOG4105CTU Proline racemase FOC12_10130 ENOG4105DER m42 family FOC12_10150 ENOG4105CGU Enoyl-CoA hydratase FOC12_10165 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_10170 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC12_10180 ENOG4106AKK s-layer domain-containing protein FOC12_10220 ENOG4105CHH sulfate transporter FOC12_10235 ENOG4105D4P Coproporphyrinogen iii oxidase FOC12_10265 ENOG4107FQX Alpha-acetolactate decarboxylase FOC12_10300 ENOG410839P FOC12_10315 ENOG4105CDA abc transporter atp-binding protein FOC12_10320 ENOG4105DRP amino acid AbC transporter FOC12_10335 ENOG4105BZ1 (ABC) transporter FOC12_10340 ENOG4105C26 Dehydrogenase FOC12_10350 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC12_10355 ENOG4105D5Q Arginine ornithine antiporter FOC12_10365 ENOG4105CH6 catalase FOC12_10370 ENOG4107RKG DJ-1/PfpI family FOC12_10380 ENOG4105E5W Transporter FOC12_10385 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC12_10390 ENOG4105NF4 modulator of drug activity FOC12_10415 ENOG4105KPY Small multidrug resistance protein FOC12_10420 ENOG4105KPY Small multidrug resistance protein FOC12_10430 ENOG4108YXU transcriptional regulator AsnC family FOC12_10435 ENOG4108PCN EamA-like transporter family FOC12_10470 ENOG4106KNT transcriptional regulator FOC12_10480 ENOG4107RWR Sodium hydrogen exchanger FOC12_10485 ENOG4105CUB amino acid FOC12_10515 ENOG4107T5V SNARE associated Golgi FOC12_10550 ENOG4105WEF catalase FOC12_10580 ENOG4105C19 ABC transporter FOC12_10585 ENOG4107RBB ABC transporter, permease FOC12_10590 ENOG41069ER domain protein FOC12_10610 ENOG4105VZJ PTS System FOC12_10615 ENOG4105VCP PTS System FOC12_10620 ENOG4105EMD TRANSCRIPTIONal FOC12_10645 ENOG4108KGH TRANSCRIPTIONal FOC12_10655 ENOG41087NI Sulfite exporter TauE/SafE FOC12_10660 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC12_10670 ENOG41085GJ domain protein FOC12_10675 ENOG4105VFE sira family FOC12_10680 ENOG4107TPS domain protein FOC12_10685 ENOG4105VFE sira family FOC12_10690 ENOG4105XTG Pfam:DUF156 FOC12_10695 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC12_10720 ENOG4105ED1 spovr family FOC12_10725 ENOG4107Y03 Nitroreductase FOC12_10780 ENOG4105C5Y PTS System FOC12_10810 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_10825 ENOG4108INS Transcriptional regulator FOC12_10875 ENOG4105DWF phosphomethylpyrimidine kinase FOC12_10880 ENOG4105D06 uba thif-type nad fad binding protein FOC12_10895 ENOG41080HI glycine oxidase FOC12_10900 ENOG4108VEU Thiamine monophosphate synthase FOC12_10910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC12_10920 ENOG4105ETU transcriptional activator (TenA FOC12_10940 ENOG41080XQ Signal transduction protein with cbs domains FOC12_11065 ENOG4105E2Z phosphate ABC transporter (Permease FOC12_11070 ENOG4105C8U phosphate abc transporter FOC12_11075 ENOG4105CVA phosphate FOC12_11080 ENOG4105CE1 Ferrous iron transport protein b FOC12_11085 ENOG4105CE1 Ferrous iron transport protein b FOC12_11090 ENOG4105CE1 Ferrous iron transport protein b FOC12_11095 ENOG4108NHD germination protein FOC12_11110 ENOG4105E1V na solute symporter FOC12_11115 ENOG4106CAD Protein of unknown function (DUF3311) FOC12_11130 ENOG4108IQI permease FOC12_11135 ENOG4105E2S oxidase) subunit II FOC12_11140 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC12_11180 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_11185 ENOG4105C85 amino acid FOC12_11205 ENOG4105DUX Transporter FOC12_11215 ENOG4107D63 FOC12_11220 ENOG4105VZ8 Transcriptional regulator FOC12_11225 ENOG41069ER domain protein FOC12_11230 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC12_11235 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_11295 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC12_11300 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC12_11305 ENOG4105CNN ABC, transporter FOC12_11320 ENOG4108RVA ribokinase FOC12_11325 ENOG4105ETE Transcriptional regulator (LacI family FOC12_11335 ENOG41067TZ transcriptional regulator, MarR family FOC12_11340 ENOG4105CXY transporter FOC12_11350 ENOG4108JQ7 (ABC) transporter FOC12_11355 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_11365 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC12_11375 ENOG41068KF Universal stress protein FOC12_11380 ENOG4105CHH sulfate transporter FOC12_11395 ENOG4105BZU Histidine kinase FOC12_11400 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC12_11405 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC12_11430 ENOG4108IQI permease FOC12_11435 ENOG4105DRP amino acid AbC transporter FOC12_11440 ENOG4105EAD ABC transporter FOC12_11445 ENOG4105CT1 (ABC) transporter FOC12_11450 ENOG4105CDA abc transporter atp-binding protein FOC12_11455 ENOG4105BZG amino acid carrier protein FOC12_11460 ENOG4105CRN Aminoglycoside phosphotransferase FOC12_11470 ENOG4105E1K spore germination protein FOC12_11485 ENOG4105CG3 alpha amylase, catalytic region FOC12_11490 ENOG4105C5Y PTS System FOC12_11495 ENOG4107414 GntR family transcriptional regulator FOC12_11500 ENOG4105D5Q Arginine ornithine antiporter FOC12_11505 ENOG4105BZU Histidine kinase FOC12_11520 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC12_11525 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC12_11530 ENOG4107T89 von Willebrand factor, type A FOC12_11540 ENOG4105EXW epimerase dehydratase FOC12_11550 ENOG4105DMQ Methyltransferase FOC12_11555 ENOG4105E0A ABC, transporter FOC12_11560 ENOG4108IHU transport system permease protein FOC12_11565 ENOG4105DQ5 transport system permease protein FOC12_11570 ENOG4108MES Periplasmic binding protein FOC12_11575 ENOG4105DUX Transporter FOC12_11590 ENOG4105DAA L-lactate FOC12_11595 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_11600 ENOG4105C37 (CBS) domain FOC12_11605 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC12_11610 ENOG4105D9N nucleoside FOC12_11615 ENOG4108KGH TRANSCRIPTIONal FOC12_11620 ENOG41073R8 VanW family FOC12_11655 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC12_11660 ENOG4105C59 p-type ATPase FOC12_11670 ENOG4105CUB amino acid FOC12_11690 ENOG4108JB9 formate dehydrogenase FOC12_11695 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC12_11700 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC12_11705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_11710 ENOG4105BZU Histidine kinase FOC12_11720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC12_11725 ENOG4108UZ3 Transporter FOC12_11735 ENOG4105C6K Malic enzyme FOC12_11745 ENOG4108MRH transcriptional regulatory protein FOC12_11770 ENOG4105US7 Histidine kinase FOC12_11775 ENOG4108STX response regulator FOC12_11780 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC12_11785 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC12_11790 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC12_11795 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC12_11800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC12_11805 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC12_11825 ENOG4105D4T Citrate transporter FOC12_11835 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC12_11845 ENOG4105DZ6 Band 7 protein FOC12_11860 ENOG4105C94 Transporter FOC12_11880 ENOG4105CYN Serine protein kinase FOC12_11885 ENOG4105BZU Histidine kinase FOC12_11890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC12_11900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC12_11910 ENOG4107ZQN disulfide bond FOC12_11915 ENOG4108JQC penicillin-binding protein 1A FOC12_12030 ENOG4105G5W regulator Fur family FOC12_12035 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC12_12055 ENOG4108IUW ABC transporter FOC12_12065 ENOG4105CBC glutamate synthase FOC12_12070 ENOG4107NBY Membrane FOC12_12075 ENOG4105BZ1 (ABC) transporter FOC12_12095 ENOG4106BXE FOC12_12100 ENOG4105CEN a g-specific adenine glycosylase FOC12_12105 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC12_12135 ENOG4105ECP epimerase FOC12_12140 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC12_12160 ENOG4105F1A Pyruvate formate-lyase FOC12_12180 ENOG4105C3I Nad-dependent epimerase dehydratase FOC12_12185 ENOG4107QQG Dehydrogenase FOC12_12195 ENOG4105CKK Glycosyl transferase, family 2 FOC12_12210 ENOG4108A04 Beta-lactamase FOC12_12220 ENOG4105CSV Glutaminase FOC12_12245 ENOG4108IQI permease FOC12_12255 ENOG4108JUB Transcriptional regulator FOC12_12265 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC12_12520 ENOG4108IMY Transcriptional regulator FOC12_12525 ENOG4105VTR Integrase FOC12_12530 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC12_12570 ENOG4105UPD Calcium Proton FOC12_12575 ENOG410606W general stress protein FOC12_12590 ENOG4107ZTW SNARE associated Golgi FOC12_12610 ENOG4108IPJ Membrane FOC12_12615 ENOG4105C59 p-type ATPase FOC12_12620 ENOG4107U9T Pfam:Ribonuclease_BN FOC12_12630 ENOG4105KJF protein tyrosine phosphatase FOC12_12650 ENOG4108TTB tellurium resistance protein FOC12_12655 ENOG4107TS3 membrane protein, TerC FOC12_12660 ENOG4106FN3 tellurium resistance protein FOC12_12665 ENOG4106FN3 tellurium resistance protein FOC12_12670 ENOG4108N0M stress protein FOC12_12685 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC12_12700 ENOG4105DEU major facilitator superfamily FOC12_12720 ENOG41062JF Transcriptional regulator FOC12_12745 ENOG4105C5H ABC transporter FOC12_12760 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC12_12775 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC12_12805 ENOG4105CI1 PTS System FOC12_12815 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_12820 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_12830 ENOG4105EAB amino acid AbC transporter FOC12_12835 ENOG4105E5Q amino acid AbC transporter FOC12_12850 ENOG4105D2S major facilitator superfamily FOC12_12855 ENOG410756H nucleotidyltransferase FOC12_12875 ENOG4105BZU Histidine kinase FOC12_12900 ENOG4106UIA FOC12_12905 ENOG4106UIA FOC12_12925 ENOG4108V5C ABC transporter FOC12_12930 ENOG4105DQ5 transport system permease protein FOC12_12935 ENOG4105EHG Permease protein FOC12_12940 ENOG4107W7X Aldolase FOC12_12950 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC12_12955 ENOG4105D3R alkyl hydroperoxide reductase FOC12_12975 ENOG4105DFD Na H antiporter FOC12_12985 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_13000 ENOG4108W15 Protein of unknown function (DUF1456) FOC12_13015 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC12_13020 ENOG4105D9N nucleoside FOC12_13040 ENOG4105KPY Small multidrug resistance protein FOC12_13045 ENOG4105C26 Dehydrogenase FOC12_13055 ENOG4108JPW Aminotransferase FOC12_13060 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC12_13065 ENOG4105CBD Diacylglycerol kinase FOC12_13090 ENOG410834F Transcriptional regulator FOC12_13110 ENOG4105D01 (LipO)protein FOC12_13115 ENOG4108UMI ABC transporter, permease FOC12_13120 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_13125 ENOG4108W2Y isochorismatase FOC12_13150 ENOG4105C4R Atp-dependent dna helicase FOC12_13175 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC12_13185 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC12_13210 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC12_13220 ENOG4105C83 adenylosuccinate lyase FOC12_13225 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC12_13230 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC12_13250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_13270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC12_13310 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_13345 ENOG4105BZU Histidine kinase FOC12_13355 ENOG4105C7N Xanthine uracil vitamin C permease FOC12_13375 ENOG4108TYN CAAX amino terminal protease family protein FOC12_13390 ENOG4105C5H ABC transporter FOC12_13395 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC12_13400 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC12_13405 ENOG41072GX Peptidase M22 Glycoprotease FOC12_13410 ENOG4105K8N protein family UPF0079, ATPase FOC12_13510 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC12_13520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC12_13525 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC12_13535 ENOG4107ZXI Rhomboid family FOC12_13550 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC12_13560 ENOG4108SC4 )-transporter FOC12_13570 ENOG4105ERH Fumarylacetoacetate hydrolase FOC12_13575 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC12_13595 ENOG4108JQ7 (ABC) transporter FOC12_13600 ENOG4105C3U ABC transporter FOC12_13605 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_13615 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC12_13630 ENOG4105C5H ABC transporter FOC12_13650 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC12_13655 ENOG4108RE7 deoxyribonuclease FOC12_13665 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC12_13685 ENOG4105F6E Acyl-transferase FOC12_13705 ENOG4105EGI Transcriptional regulator FOC12_13715 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC12_13725 ENOG4105E0C molybdate abc transporter FOC12_13735 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC12_13740 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_13750 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC12_13755 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC12_13785 ENOG4108JQ7 (ABC) transporter FOC12_13790 ENOG4105C3U ABC transporter FOC12_13795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_13800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC12_13815 ENOG4105C2C drug resistance transporter, Bcr CflA FOC12_13830 ENOG4105IQ5 FAD linked oxidase domain protein FOC12_13840 ENOG4105EE1 crotonyl-CoA reductase FOC12_13845 ENOG4105D01 (LipO)protein FOC12_13850 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_13855 ENOG4108UMI ABC transporter, permease FOC12_13890 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC12_13895 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC12_13915 ENOG4108VQT Alpha beta hydrolase fold protein FOC12_13920 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC12_13935 ENOG4107U5W ybbr family FOC12_13940 ENOG4105C8B TIGR00159 family FOC12_14020 ENOG4108NMV polysaccharide deacetylase FOC12_14035 ENOG4105D1F ATP-binding protein FOC12_14060 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC12_14065 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC12_14070 ENOG4108JJB ABC transporter FOC12_14100 ENOG41067V7 50S ribosomal protein L36 FOC12_14110 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_14120 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC12_14145 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC12_14250 ENOG4105XPM ribosomal protein FOC12_14255 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC12_14265 ENOG4107Y49 methyltransferase FOC12_14290 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC12_14305 ENOG4105QIV RNA polymerase FOC12_14310 ENOG4105M0M Tetracycline resistance protein FOC12_14315 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC12_14330 ENOG4105D7W serine acetyltransferase FOC12_14350 ENOG4105CTP PilT protein domain protein FOC12_14360 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC12_14375 ENOG4108Z0C Uvrb UvrC protein FOC12_14405 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC12_14415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC12_14420 ENOG4105KRF dihydroneopterin aldolase FOC12_14425 ENOG4105EEI dihydropteroate synthase FOC12_14430 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC12_14435 ENOG4105DDQ anthranilate synthase FOC12_14440 ENOG4105CRQ synthase (Component I) FOC12_14445 ENOG4105C6T cysteine synthase FOC12_14460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC12_14465 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC12_14470 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC12_14490 ENOG41060GV RNA binding s1 domain protein FOC12_14505 ENOG4105VYY sporulation protein yabp FOC12_14510 ENOG41082I2 s4 domain protein FOC12_14515 ENOG4108IY2 MazG family FOC12_14525 ENOG4108M14 stage v sporulation protein t FOC12_14530 ENOG4108JA2 transcriptioN-repair coupling factor FOC12_14540 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC12_14545 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC12_14560 ENOG4105KME endoribonuclease L-psp FOC12_14565 ENOG4105DFT pur operon repressor FOC12_14580 ENOG4105W42 Veg protein FOC12_14585 ENOG4105XFA sporulation peptidase YabG FOC12_14595 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC12_14600 ENOG4105F8V Hydrolase, tatD family FOC12_14610 ENOG4105KRN Transcriptional regulator, abrb family FOC12_14615 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC12_14625 ENOG41060K3 Methyltransferase FOC12_14635 ENOG4105MA4 psp1 domain protein FOC12_14640 ENOG4105FA2 dna polymerase iii FOC12_14650 ENOG4105CXN decarboxylase FOC12_14685 ENOG41067KS pro-sigma K processing FOC12_14705 ENOG4105C6E dna polymerase iii FOC12_14715 ENOG4108Z6B deaminase FOC12_14720 ENOG4105GTG Isochorismatase FOC12_14730 ENOG4105ZMH deoxynucleoside kinase FOC12_14765 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC12_14800 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC12_14815 ENOG410848D S4 domain protein YaaA FOC12_14820 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC12_14840 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC12_14850 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC12_14870 ENOG4107QJE Chromosome Partitioning Protein FOC12_14875 ENOG4105FA0 parb-like partition protein FOC12_14880 ENOG4108ZDA Sporulation protein YyaC FOC12_14885 ENOG4105D8X mechanosensitive ion channel FOC12_14890 ENOG4105VDK protein, conserved in bacteria FOC12_14895 ENOG4105C3G gtp-binding protein FOC12_14905 ENOG4108UUM single-stranded DNA-binding protein FOC12_14915 ENOG4108XMW Membrane FOC12_14920 ENOG4105BZR domain protein FOC12_14930 ENOG4105CDU Replicative dna helicase FOC12_14960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_14965 ENOG4105BZU Histidine kinase FOC12_14980 ENOG4105Q2H domain protein FOC12_14985 ENOG4105C0H protease FOC12_15005 ENOG4105DPN Oligoendopeptidase f FOC12_15020 ENOG4105C1J atp-dependent rna helicase FOC12_15030 ENOG4108UT2 hemolysin iii FOC12_15035 ENOG4105CMR udp-glucose 4-epimerase FOC12_15045 ENOG4105IW1 AmiS UreI transporter FOC12_15055 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_15070 ENOG4107RGD Major Facilitator superfamily FOC12_15075 ENOG4108HRK Histidine kinase FOC12_15080 ENOG4105DY9 regulatoR FOC12_15095 ENOG4106F5Q Membrane FOC12_15100 ENOG4105E0X reductase FOC12_15110 ENOG41067SE Tetr family transcriptional regulator FOC12_15115 ENOG4105CKK Glycosyl transferase, family 2 FOC12_15135 ENOG4105C5H ABC transporter FOC12_15140 ENOG4105JEU Glycosyl transferase, family 2 FOC12_15150 ENOG4108S4H thioesterase Superfamily protein FOC12_15160 ENOG4106YBV Methyl-accepting chemotaxis FOC12_15165 ENOG4105EN6 Membrane FOC12_15185 ENOG41079KZ Major Facilitator Superfamily FOC12_15190 ENOG4105DY9 regulatoR FOC12_15195 ENOG4105D22 carbon starvation protein FOC12_15200 ENOG4105VCD cytoplasmic protein FOC12_15205 ENOG4105BZU Histidine kinase FOC12_15210 ENOG4105DWF phosphomethylpyrimidine kinase FOC12_15220 ENOG4105WH1 Two component transcriptional regulator luxr family FOC12_15230 ENOG4108Y4K DNA-binding transcriptional activator FOC12_15255 ENOG4105D6E homoserine dehydrogenase FOC12_15270 ENOG41090WU lipolytic protein G-D-S-L family FOC12_15275 ENOG4105CJ1 ABC, transporter FOC12_15280 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC12_15290 ENOG4105VCH membrane FOC12_15295 ENOG410667J hydrolase FOC12_15325 ENOG4108VKI Cell wall hydrolase FOC12_15340 ENOG4108IJ2 phosphate acetyltransferase FOC12_15355 ENOG4108VCI transcription factor, rsfa family FOC12_15370 ENOG4105EHG Permease protein FOC12_15375 ENOG4105E0A ABC, transporter FOC12_15380 ENOG4108MES Periplasmic binding protein FOC12_15385 ENOG4105DCI Phosphohydrolase FOC12_15390 ENOG41069HH 4-oxalocrotonate tautomerase FOC12_15395 ENOG4108Z4T Peptidase M50 FOC12_15400 ENOG4108XFG YwhD family FOC12_15405 ENOG4105BZ4 penicillin-binding protein FOC12_15410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC12_15415 ENOG4107SWG transcriptional regulator MERR family FOC12_15420 ENOG4105DXB Major Facilitator superfamily FOC12_15430 ENOG4105CYW agmatinase FOC12_15450 ENOG410684U Domain of unknown function (DUF1934) FOC12_15460 ENOG4105EMN RNA polymerase sigma factor FOC12_15480 ENOG4105IIU Aminopeptidase FOC12_15490 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC12_15495 ENOG4108M15 ABC transporter FOC12_15500 ENOG4105KCT ABC transporter FOC12_15505 ENOG4105BZU Histidine kinase FOC12_15535 ENOG4105BZU Histidine kinase FOC12_15550 ENOG4105DF6 Fe-S oxidoreductase FOC12_15560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC12_15565 ENOG4105C1G acyl-Coa dehydrogenase FOC12_15570 ENOG4105C1G acyl-Coa dehydrogenase FOC12_15605 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC12_15610 ENOG4105CBT Fructose-1,6-bisphosphatase FOC12_15615 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC12_15630 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC12_15635 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC12_15640 ENOG4108ZXQ stage ii sporulation protein r FOC12_15650 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC12_15665 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC12_15670 ENOG4108VGI doxx family FOC12_15685 ENOG4108YZG isomerase FOC12_15715 ENOG41062M3 atp synthase FOC12_15720 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC12_15770 ENOG4105BZU Histidine kinase FOC12_15775 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC12_15785 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC12_15790 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC12_15815 ENOG4105D65 subunit l FOC12_15820 ENOG4105C8S subunit m FOC12_15825 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC12_15830 ENOG4106778 Protein of unknown function (DUF1146) FOC12_15850 ENOG4108IUW ABC transporter FOC12_15855 ENOG4105DY9 regulatoR FOC12_15870 ENOG4105FRN stage II sporulation protein FOC12_15885 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC12_15940 ENOG4105EY8 ABC transporter FOC12_15945 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC12_15960 ENOG4105CMR udp-glucose 4-epimerase FOC12_15965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_15970 ENOG4105BZU Histidine kinase FOC12_15985 ENOG4105CXY transporter FOC12_16005 ENOG4105C19 ABC transporter FOC12_16010 ENOG4107RBB ABC transporter, permease FOC12_16020 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_16050 ENOG4105C0D helicase FOC12_16055 ENOG4105KBK Zinc finger, swim domain protein FOC12_16080 ENOG41069ER domain protein FOC12_16085 ENOG4105C94 Transporter FOC12_16115 ENOG4105E0M Sulfatase FOC12_16125 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC12_16135 ENOG4105DAA L-lactate FOC12_16175 ENOG4107RSM transcriptional regulator FOC12_16180 ENOG4105ECB domain protein FOC12_16185 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_16200 ENOG4105VZJ PTS System FOC12_16210 ENOG4105VCP PTS System FOC12_16215 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC12_16220 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC12_16230 ENOG4105CK1 PTS System FOC12_16235 ENOG4105VCP PTS System FOC12_16240 ENOG4105F8D glycoside hydrolase family 4 FOC12_16245 ENOG410901P UPF0249 protein FOC12_16260 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC12_16270 ENOG4105ESV Glycosyl transferase, family 4 FOC12_16275 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC12_16280 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC12_16285 ENOG4108KGH TRANSCRIPTIONal FOC12_16290 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC12_16300 ENOG4105KVH Transcriptional regulator FOC12_16315 ENOG41081UC Inherit from COG: Competence protein FOC12_16320 ENOG4105VEQ Cold shock protein FOC12_16325 ENOG4105MS2 ribosomal subunit Interface protein FOC12_16330 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC12_16350 ENOG4105CAK Cell division ATP-binding protein ftsE FOC12_16355 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC12_16360 ENOG4105CN1 protease FOC12_16370 ENOG4105BZ1 (ABC) transporter FOC12_16385 ENOG4108WS4 fmn reductase FOC12_16395 ENOG4105DUM transcriptional regulator, lysR family FOC12_16400 ENOG4105HMI Membrane FOC12_16425 ENOG4107TXC Transcriptional regulator FOC12_16440 ENOG4105D7V transposase FOC12_16445 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC12_16450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC12_16460 ENOG41086DT Membrane protein of unknown function FOC12_16480 ENOG4108S4C acetyltransferase FOC12_16490 ENOG4105C3M thioredoxin reductase FOC12_16500 ENOG4108Z4K mutator MutT protein FOC12_16510 ENOG4105CHW UPF0052 protein FOC12_16520 ENOG4105KRI phosphocarrier protein (HPr FOC12_16525 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC12_16530 ENOG4105H67 Protein of unknown function (DUF421) FOC12_16545 ENOG4105CZ3 stage V sporulation protein ad FOC12_16550 ENOG41090VF Stage v sporulation protein ac FOC12_16570 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_16595 ENOG4105CP7 Triose-phosphate isomerase FOC12_16600 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC12_16610 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC12_16635 ENOG4105EFC phage portal protein HK97 family FOC12_16730 ENOG41067MG lrgb family FOC12_16735 ENOG4105XZU Preprotein translocase, subunit SecG FOC12_16745 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC12_16775 ENOG4105CM4 permease protein FOC12_16780 ENOG4108IPW abc transporter atp-binding protein FOC12_16795 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC12_16800 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC12_16815 ENOG4105WMR Protein CrcB homolog FOC12_16820 ENOG4105WMR Protein CrcB homolog FOC12_16830 ENOG4105C8Q Methyl-accepting chemotaxis FOC12_16840 ENOG4105D4A Cell wall formation (By similarity) FOC12_16845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC12_16860 ENOG4105KVH Transcriptional regulator FOC12_16865 ENOG4105F27 Major Facilitator FOC12_16870 ENOG4105CV8 reductase FOC12_16885 ENOG4108RYK Nad-dependent epimerase dehydratase FOC12_16900 ENOG4105D9N nucleoside FOC12_16905 ENOG4105D9N nucleoside FOC12_16925 ENOG4108URH decarboxylase FOC12_16940 ENOG4108RMU ferritin dps family protein FOC12_16950 ENOG4105NCW Trka-c domain protein FOC12_16955 ENOG4107S91 Sodium hydrogen exchanger FOC12_16975 ENOG4105D4Y metalloprotease FOC12_16980 ENOG4105VG1 fes assembly suf system protein FOC12_16995 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC12_17005 ENOG4105BZU Histidine kinase FOC12_17010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_17015 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC12_17025 ENOG4107ZTW SNARE associated Golgi FOC12_17060 ENOG4107AYK membrAne FOC12_17070 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC12_17080 ENOG4107R7I amino acid FOC12_17085 ENOG4108SUT Major Facilitator Superfamily FOC12_17100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC12_17120 ENOG4105DZ1 carboxypeptidase FOC12_17135 ENOG4105CHU acetyl-coa acetyltransferase FOC12_17140 ENOG4105C1G acyl-Coa dehydrogenase FOC12_17145 ENOG4108W8B Beta-lactamase domain protein FOC12_17170 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_17215 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC12_17250 ENOG4108UMI ABC transporter, permease FOC12_17255 ENOG4105D01 (LipO)protein FOC12_17260 ENOG4105D01 (LipO)protein FOC12_17265 ENOG4105C3K feS assembly ATPase SufC FOC12_17270 ENOG4105JRK feS assembly protein SufD FOC12_17275 ENOG4105C9B Cysteine desulfurase FOC12_17280 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC12_17285 ENOG4105DIW FeS assembly protein SUFB FOC12_17300 ENOG4107R8B 5'-nucleotidase FOC12_17305 ENOG4105KZD Domain of unknown function (DUF1805) FOC12_17315 ENOG4105FAA peptidase M23 FOC12_17340 ENOG41090T1 Membrane FOC12_17345 ENOG4107TXC Transcriptional regulator FOC12_17350 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC12_17355 ENOG4105MMD transcriptional regulator FOC12_17370 ENOG4105CBT Fructose-1,6-bisphosphatase FOC12_17385 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC12_17390 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC12_17400 ENOG4108W5N phosphatidylglycerophosphatase a FOC12_17415 ENOG41083MR nifu domain-containing protein FOC12_17460 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC12_17465 ENOG4105C4B ABC transporter, permease FOC12_17470 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC12_17495 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC12_17515 ENOG4105EWC Purine nucleoside phosphorylase FOC12_17545 ENOG4105CEP NADH dehydrogenase FOC12_17560 ENOG41069ER domain protein FOC12_17580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC12_17600 ENOG4105KA0 thioesterase Superfamily protein FOC12_17605 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC12_17620 ENOG4107R3E Citrate transporter FOC12_17630 ENOG4105Y38 Kinase-associated protein B FOC12_17640 ENOG4105C87 Aminotransferase class I and II FOC12_17650 ENOG4108MUZ hydrolase FOC12_17655 ENOG4105C5I Dehydrogenase FOC12_17660 ENOG4108ZB6 transcriptional regulator AsnC family FOC12_17665 ENOG4105CHM Aminotransferase FOC12_17675 ENOG4105WG9 Conserved Protein FOC12_17680 ENOG4107QYV phosphohexose isomerase FOC12_17690 ENOG4107PBV potassium channel FOC12_17695 ENOG4105KT7 mgtC SapB transporter FOC12_17730 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC12_17825 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC12_17845 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC12_17855 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC12_17875 ENOG4105VEQ Cold shock protein FOC12_17885 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC12_17890 ENOG4105E4F Isochorismate synthase FOC12_17895 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC12_17900 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC12_17905 ENOG4108IPT Naphthoate synthase FOC12_17915 ENOG4105DTQ mandelate racemase muconate lactonizing FOC12_17945 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC12_17965 ENOG4105FDP GntR family transcriptional regulator FOC12_17970 ENOG4105C6Z Gluconate FOC12_18010 ENOG41086D8 Transcriptional regulator FOC12_18015 ENOG4105C19 ABC transporter FOC12_18030 ENOG4107ZTW SNARE associated Golgi FOC12_18065 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC12_18070 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC12_18095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_18100 ENOG4105BZU Histidine kinase FOC12_18135 ENOG41087YS Phage shock protein A FOC12_18180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC12_18185 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC12_18190 ENOG4108V2W Carbonate dehydratase FOC12_18245 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC12_18255 ENOG4105D2X ABC transporter substrate-binding protein FOC12_18275 ENOG4107S9D Alpha beta hydrolase FOC12_18280 ENOG4105BZU Histidine kinase FOC12_18285 ENOG4105BZU Histidine kinase FOC12_18290 ENOG4105EGD dinuclear metal center protein, YbgI family FOC12_18340 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC12_18350 ENOG4105BZF Glycosyl transferase (Group 1 FOC12_18355 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC12_18360 ENOG4108Z0R Transferase FOC12_18365 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC12_18395 ENOG4105DA5 (ABC) transporter FOC12_18405 ENOG4105N5T Radical SAM Protein FOC12_18425 ENOG4105C19 ABC transporter FOC12_18440 ENOG4105NCW Trka-c domain protein FOC12_18445 ENOG4107S91 Sodium hydrogen exchanger FOC12_18450 ENOG410605W Major Facilitator FOC12_18480 ENOG4108B31 Spore germination protein FOC12_18490 ENOG4105DWV Homoserine O-trans-acetylase FOC12_18500 ENOG41085GJ domain protein FOC12_18525 ENOG4105D06 uba thif-type nad fad binding protein FOC12_18535 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_18540 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC12_18545 ENOG4108ZAF Molybdopterin FOC12_18560 ENOG4105CSC Glucose uptake protein FOC12_18565 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC12_18570 ENOG4108VJ1 Transcriptional regulator (CarD family FOC12_18605 ENOG4105CBX hi0933 family FOC12_18620 ENOG4105YW5 deoR family transcriptional regulator FOC12_18635 ENOG4108IUM Glycogen debranching enzyme FOC12_18640 ENOG4108V15 phosphotransferase enzyme family FOC12_18655 ENOG4105C8F Beta-lactamase domain protein FOC12_18685 ENOG4108VDD TRNA binding domain protein FOC12_18730 ENOG4105C88 aminopeptidase FOC12_18750 ENOG4105ETE Transcriptional regulator (LacI family FOC12_18780 ENOG4105EP9 oxidoreductase FOC12_18785 ENOG4107SNB ankyrin repeat protein YahD FOC12_18795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_18805 ENOG4105DGU Histone deacetylase FOC12_18810 ENOG4105W87 Cbs domain FOC12_18815 ENOG4105F1V Acetoin utilization protein FOC12_18835 ENOG4105EMN RNA polymerase sigma factor FOC12_18845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC12_18865 ENOG4105C28 cystathionine FOC12_18885 ENOG4106KR7 LysR family Transcriptional regulator FOC12_18910 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC12_18920 ENOG4105EFZ amidohydrolase FOC12_18935 ENOG4105KBJ sporulation protein ytfj FOC12_18940 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC12_18950 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC12_18970 ENOG4108JYZ YitT family FOC12_19010 ENOG4107YZX Universal stress protein FOC12_19030 ENOG4105VZ8 Transcriptional regulator FOC12_19040 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC12_19045 ENOG4105Z7P Acetyltransferase (GNAT) family FOC12_19080 ENOG4105DC7 peptidase M24 FOC12_19115 ENOG4105SFS phosphoesterase RecJ domain protein FOC12_19125 ENOG4105VV2 FOC12_19130 ENOG4105C0B DNA polymerase III (alpha subunit) FOC12_19135 ENOG4105C6K Malic enzyme FOC12_19140 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC12_19165 ENOG4105FS0 cytoplasmic membrane protein FOC12_19170 ENOG4108REF Sporulation integral membrane protein ytvi FOC12_19180 ENOG4105BZN citrate synthase FOC12_19185 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC12_19200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_19205 ENOG4105BZU Histidine kinase FOC12_19210 ENOG4105C2M dna polymerase I FOC12_19215 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC12_19225 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC12_19230 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC12_19240 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC12_19260 ENOG4108TDW sporulation protein YtxC FOC12_19265 ENOG4105C22 threonyL-tRNA synthetase FOC12_19270 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC12_19290 ENOG4105CN9 Peptidase m42 family protein FOC12_19295 ENOG4108JGH Tetr family transcriptional regulator FOC12_19300 ENOG4105CW7 secretion protein, HlyD family FOC12_19305 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_19340 ENOG4108RWN rrna methyltransferase FOC12_19350 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC12_19355 ENOG4105C5S asparaginyl-tRNA synthetase FOC12_19390 ENOG4105DCG PHP domain protein FOC12_19400 ENOG4105FE9 pseudouridine synthase FOC12_19410 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC12_19420 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC12_19435 ENOG4105E0A ABC, transporter FOC12_19440 ENOG4105KFN sortase, SrtB family FOC12_19455 ENOG4105DR4 Methyltransferase FOC12_19465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC12_19505 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC12_19510 ENOG4105J76 Periplasmic binding protein FOC12_19520 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_19525 ENOG4107Z3H Transcriptional regulator, TetR family FOC12_19530 ENOG41060WC Enoyl-CoA hydratase FOC12_19535 ENOG4105BZJ Electron transfer flavoprotein FOC12_19540 ENOG4105C10 Electron transfer flavoprotein FOC12_19545 ENOG4105K63 Thioredoxin FOC12_19560 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC12_19570 ENOG4105E33 succinate dehydrogenase FOC12_19580 ENOG4108VXD carboxy-peptidase FOC12_19585 ENOG4105E14 MotA TolQ exbB proton channel FOC12_19595 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC12_19600 ENOG4108IUX (ABC) transporter FOC12_19605 ENOG4105RHA ABC transporter, permease FOC12_19610 ENOG4108Z40 Transcriptional regulator FOC12_19615 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC12_19625 ENOG4108JCI Transcriptional regulator FOC12_19630 ENOG41067S9 phage shock protein C, PspC FOC12_19645 ENOG4105DY9 regulatoR FOC12_19655 ENOG4108JQ7 (ABC) transporter FOC12_19670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC12_19675 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC12_19680 ENOG4105DZC cytosine deaminase FOC12_19685 ENOG4105DZC cytosine deaminase FOC12_19700 ENOG4105PFC Transcriptional regulator FOC12_19715 ENOG4105KBX Transcriptional regulator, TetR family FOC12_19725 ENOG4108PCX Major Facilitator FOC12_19735 ENOG4108XJQ germination protein FOC12_19745 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC12_19750 ENOG4105M59 Phosphodiesterase, mj0936 family FOC12_19770 ENOG4108QCI YvbH-like oligomerisation region FOC12_19795 ENOG4108IUQ atp-dependent protease FOC12_19815 ENOG4105K56 Transcriptional regulator FOC12_19840 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC12_19850 ENOG41068KH stage VI sporulation protein D FOC12_19860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC12_19865 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC12_19885 ENOG4105DFF Rod shape-determining protein mreb FOC12_19890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC12_19905 ENOG4107QMS site-determining protein FOC12_19920 ENOG4105C03 ribonuclease FOC12_19930 ENOG4105X36 (ribosomal) protein FOC12_19945 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC12_19975 ENOG4105CQC Prephenate dehydratase FOC12_19980 ENOG4108RPX mosc domain containing protein FOC12_19995 ENOG4108IYU L-aspartate oxidase FOC12_20000 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC12_20025 ENOG41082BM Transcriptional regulator, arsr family FOC12_20030 ENOG4108IPJ Membrane FOC12_20035 ENOG4108IPJ Membrane FOC12_20045 ENOG4108HUF Transporter FOC12_20060 ENOG41061AI Protein of unknown function (DUF2905) FOC12_20075 ENOG4105VIE preprotein translocase, subunit YajC FOC12_20085 ENOG4108QG2 Membrane FOC12_20090 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC12_20100 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC12_20105 ENOG41076HS cation diffusion facilitator family transporter FOC12_20110 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC12_20120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC12_20130 ENOG4105CUT histidyl-tRNA synthetase FOC12_20140 ENOG4105CUZ uba thif-type nad fad binding protein FOC12_20145 ENOG4108VCI transcription factor, rsfa family FOC12_20150 ENOG4105D1H recombination factor protein RarA FOC12_20160 ENOG4105C3J Cysteine desulfurase FOC12_20165 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC12_20175 ENOG4105C7H Helicase, RecD TraA family FOC12_20180 ENOG41060CR FOC12_20195 ENOG4105C02 permease FOC12_20205 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_20225 ENOG4105HHA aminodeoxychorismate lyase FOC12_20230 ENOG4108VQJ O-methyltransferase FOC12_20235 ENOG4105XYU peptidase (U32 family) FOC12_20240 ENOG4105CFP Peptidase U32 FOC12_20255 ENOG4107XRG penicillin-binding protein FOC12_20285 ENOG4105C28 cystathionine FOC12_20290 ENOG4108EKI Dehydrogenase FOC12_20300 ENOG4108V5C ABC transporter FOC12_20305 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC12_20355 ENOG4105MIR Phenylalanine 4-monooxygenase FOC12_20395 ENOG4108MUZ hydrolase FOC12_20405 ENOG4105G6Z alkaline phosphatase FOC12_20420 ENOG4108TVJ Nitroreductase FOC12_20440 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_20455 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC12_20460 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC12_20470 ENOG410812S Rna-binding protein FOC12_20480 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC12_20490 ENOG4105DXX methyltransferase FOC12_20500 ENOG4105KQC Competence protein FOC12_20505 ENOG4108UK2 deaminase FOC12_20510 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC12_20520 ENOG4105TQK DNA polymerase iii, delta' subunit FOC12_20545 ENOG4105KVH Transcriptional regulator FOC12_20550 ENOG4105CSA Coproporphyrinogen iii oxidase FOC12_20560 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC12_20580 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC12_20585 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC12_20595 ENOG4105KTH gatB Yqey FOC12_20600 ENOG41068P3 sporulation protein YqfC FOC12_20610 ENOG4105C9A Phoh family FOC12_20615 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC12_20625 ENOG4107YR5 Diacylglycerol kinase FOC12_20630 ENOG4105KG3 cytidine deaminase FOC12_20635 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC12_20660 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC12_20665 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_20680 ENOG4105EGD dinuclear metal center protein, YbgI family FOC12_20705 ENOG41069ZM Protein of unknown function (DUF2624) FOC12_20710 ENOG4108JYZ YitT family FOC12_20715 ENOG4105FDK ABC transporter FOC12_20725 ENOG4105N80 Ferric uptake regulator, Fur family FOC12_20750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC12_20760 ENOG4107RF6 penicillin-binding protein FOC12_20765 ENOG4105PWN phosphate abc transporter FOC12_20770 ENOG4105C8U phosphate abc transporter FOC12_20775 ENOG4105E2Z phosphate ABC transporter (Permease FOC12_20780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC12_20785 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC12_20800 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC12_20810 ENOG4105DKQ ROK family FOC12_20820 ENOG4105C5X domain protein FOC12_20840 ENOG4105C28 cystathionine FOC12_20845 ENOG4105C28 cystathionine FOC12_20855 ENOG4105C3R Methionine synthase FOC12_20860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC12_20980 ENOG4105C0D helicase FOC12_21010 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_21015 ENOG4105CJ1 ABC, transporter FOC12_21050 ENOG41080TC multidrug resistance protein FOC12_21070 ENOG4105WZW rhodanese family FOC12_21075 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC12_21095 ENOG4107YBY Hydrolase FOC12_21105 ENOG4105CBJ Metal-dependent enzyme FOC12_21120 ENOG4105DC7 peptidase M24 FOC12_21145 ENOG4105CD2 stage iii sporulation protein aa FOC12_21150 ENOG4105KR5 Stage iii sporulation protein FOC12_21155 ENOG4108CQH stage III sporulation protein AC FOC12_21160 ENOG4105KQ4 Stage iii sporulation protein ad FOC12_21170 ENOG410644B Stage III sporulation protein af FOC12_21195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC12_21200 ENOG4108ZSR alkaline shock protein FOC12_21225 ENOG4105CTB Polyprenyl synthetase FOC12_21235 ENOG4105DX0 Hemolysin A FOC12_21245 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC12_21250 ENOG4105S1Z Stage IV sporulation protein B FOC12_21255 ENOG4107QQR Sporulation FOC12_21270 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC12_21280 ENOG4108JUB Transcriptional regulator FOC12_21290 ENOG4107RDP Dehydrogenase FOC12_21310 ENOG4105CPP Dehydrogenase, E1 component FOC12_21315 ENOG4105C7S Dehydrogenase FOC12_21330 ENOG4105G7B Protein of unknown function (DUF2992) FOC12_21340 ENOG4108HW3 (ABC) transporter FOC12_21345 ENOG4105E5Q amino acid AbC transporter FOC12_21350 ENOG4105CDA abc transporter atp-binding protein FOC12_21355 ENOG4108QEG Membrane FOC12_21360 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC12_21375 ENOG4105D9U N-acetyltransferase FOC12_21380 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC12_21390 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC12_21415 ENOG4105EJQ L-serine dehydratase FOC12_21420 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_21430 ENOG4108IXY short-chain dehydrogenase reductase FOC12_21445 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC12_21485 ENOG4105CGH 5'-nucleotidase FOC12_21490 ENOG4105DFD Na H antiporter FOC12_21500 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC12_21510 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC12_21515 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_21520 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC12_21525 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC12_21545 ENOG4108R6K riboflavin synthase, subunit alpha FOC12_21550 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC12_21570 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC12_21575 ENOG4105ETE Transcriptional regulator (LacI family FOC12_21585 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC12_21605 ENOG4105RHY Pfam:UPF0157 FOC12_21615 ENOG4105CPC Aldo Keto reductase FOC12_21635 ENOG4105MZ9 stage II sporulation protein m FOC12_21640 ENOG4105I3K Ferric uptake regulator, Fur family FOC12_21650 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC12_21675 ENOG4105D7N magnesium and cobalt transport protein CorA FOC12_21705 ENOG4105DVE abc transporter atp-binding protein FOC12_21710 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC12_21715 ENOG4105DZ1 carboxypeptidase FOC12_21720 ENOG41082AN stage II sporulation protein FOC12_21730 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_21735 ENOG4105C8J )-transporter FOC12_21755 ENOG41090VF Stage v sporulation protein ac FOC12_21760 ENOG4105CZ3 stage V sporulation protein ad FOC12_21770 ENOG4105G6R Stage v sporulation protein ae FOC12_21780 ENOG4105J7I hydrolase FOC12_21785 ENOG4105PTM secreted protein FOC12_21790 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC12_21825 ENOG4105CE4 GlcNAc 6-P deacetylase FOC12_21835 ENOG4105FDP GntR family transcriptional regulator FOC12_21845 ENOG4105CID antiterminator FOC12_21860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC12_21880 ENOG4106TD9 Diguanylate cyclase FOC12_21900 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC12_21925 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC12_21935 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC12_21945 ENOG4105DTD Dehydrogenase FOC12_21950 ENOG4105K7K Transcriptional regulator FOC12_21990 ENOG4105CHU acetyl-coa acetyltransferase FOC12_22035 ENOG4105CG3 alpha amylase, catalytic region FOC12_22045 ENOG4107FKK extracellular solute-binding protein family 1 FOC12_22055 ENOG4105EG2 ABC transporter, permease FOC12_22060 ENOG4105FKQ transcriptional regulator FOC12_22065 ENOG4105CHM Aminotransferase FOC12_22075 ENOG4108HGU Histidine kinase FOC12_22130 ENOG4105UIN FOC12_22140 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC12_22155 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC12_22160 ENOG4105EPM Diguanylate phosphodiesterase FOC12_22175 ENOG4107IN1 Protein of unknown function (DUF1797) FOC12_22180 ENOG4108XRC Protein of unknown function (DUF458) FOC12_22215 ENOG4107ZYR domain protein FOC12_22220 ENOG4105CN5 Metallo-Beta-Lactamase FOC12_22235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC12_22250 ENOG4105CPP Dehydrogenase, E1 component FOC12_22255 ENOG4105C7S Dehydrogenase FOC12_22300 ENOG4105CXN decarboxylase FOC12_22320 ENOG4105ECY inositol monophosphatase FOC12_22330 ENOG4105CI3 gtp-binding protein typa FOC12_22335 ENOG4105QA2 FOC12_22355 ENOG4108IAB Phoh family FOC12_22370 ENOG4105CNI cell division protein FtsW FOC12_22375 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC12_22425 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC12_22440 ENOG4107TB6 phosphoglycerate mutase FOC12_22460 ENOG4106H78 methyltransferase FOC12_22470 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC12_22475 ENOG4105D78 K07001 NTE family protein FOC12_22480 ENOG41063PX domain protein FOC12_22490 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC12_22510 ENOG4108IMY Transcriptional regulator FOC12_22555 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_22570 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC12_22655 ENOG4105CAR Terminase, large subunit FOC12_22665 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC12_22745 ENOG4105XSJ toxin secretion phage lysis holin FOC12_22795 ENOG4105KNH Nucleic acid-binding protein FOC12_22835 ENOG41068DC Essential cell division protein (By similarity) FOC12_22840 ENOG4105CJN penicillin-binding protein FOC12_22845 ENOG4105CJN penicillin-binding protein FOC12_22850 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC12_22865 ENOG4105CNI cell division protein FtsW FOC12_22870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC12_22875 ENOG4105D4A Cell wall formation (By similarity) FOC12_22880 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC12_22885 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC12_22890 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC12_22900 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC12_22910 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC12_22915 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC12_22920 ENOG4105DFA alanine racemase domain protein FOC12_22930 ENOG41067XK integral membrane protein FOC12_22935 ENOG4105DBK s4 domain protein FOC12_22960 ENOG4105C34 Pseudouridine synthase FOC12_22985 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC12_23040 ENOG4105DC7 peptidase M24 FOC12_23045 ENOG4105F23 Fibronectin-binding protein FOC12_23055 ENOG4105DSJ YicC domain protein FOC12_23075 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC12_23080 ENOG4105C25 Primosomal protein n' FOC12_23085 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC12_23095 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC12_23105 ENOG4108ZF3 Phosphatase FOC12_23110 ENOG4105D9P serine threonine protein kinase FOC12_23115 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC12_23120 ENOG4105DJV ribulose-phosphate 3-epimerase FOC12_23125 ENOG4105FJ0 thiamine FOC12_23140 ENOG4108ZAA Alkaline-shock protein FOC12_23145 ENOG4105DP4 dak2 domain fusion protein ylov FOC12_23150 ENOG4105CB5 ATP-dependent DNA helicase recG FOC12_23165 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC12_23170 ENOG4105CHR reductase FOC12_23185 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC12_23190 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC12_23210 ENOG4105VB6 UPF0109 protein FOC12_23235 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC12_23250 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC12_23260 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC12_23270 ENOG4108HE4 integrase family FOC12_23310 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC12_23315 ENOG4105KNE Phosphatidate cytidylyltransferase FOC12_23320 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC12_23325 ENOG4105DZP Membrane-associated zinc metalloprotease FOC12_23335 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC12_23345 ENOG4105CHV Transcription elongation factor NusA FOC12_23350 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC12_23355 ENOG4105VHM ribosomal protein FOC12_23365 ENOG4105W7A Protein of unknown function (DUF503) FOC12_23375 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC12_23380 ENOG4105DTN riboflavin biosynthesis protein ribF FOC12_23400 ENOG4105C1V Peptidase, M16 FOC12_23410 ENOG4105E35 Dipicolinate synthase subunit A FOC12_23415 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC12_23420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC12_23430 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC12_23440 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC12_23450 ENOG4107QZI cell division protein FtsK FOC12_23455 ENOG4105FDP GntR family transcriptional regulator FOC12_23460 ENOG4105DIH basic membrane FOC12_23465 ENOG4108JQ9 ABC transporter FOC12_23490 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC12_23495 ENOG4105XZV Protein of unknown function (DUF3243) FOC12_23510 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC12_23535 ENOG4105D48 metallophosphoesterase FOC12_23540 ENOG4105MCT stage V sporulation protein S FOC12_23545 ENOG4108IGT Dipeptidase FOC12_23550 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC12_23555 ENOG4105DQU oxidoreductase, subunit beta FOC12_23560 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC12_23585 ENOG4105DA5 (ABC) transporter FOC12_23610 ENOG4107QHE Choloylglycine hydrolase FOC12_23620 ENOG410890F Dynamin family FOC12_23625 ENOG4105E0M Sulfatase FOC12_23630 ENOG4107R6R udp-galactopyranose mutase FOC12_23635 ENOG4105F0V Cell wall hydrolase FOC12_23660 ENOG4107YEI lmbE family FOC12_23665 ENOG4107TTQ Alpha beta hydrolase fold FOC12_23680 ENOG41067MG lrgb family FOC12_23700 ENOG4105BZU Histidine kinase FOC12_23705 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_23735 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC12_23740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC12_23750 ENOG4105CGK Exodeoxyribonuclease III FOC12_23770 ENOG4105E0A ABC, transporter FOC12_23775 ENOG4105NIV Esterase FOC12_23785 ENOG4105VPX protein, conserved in bacteria FOC12_23790 ENOG410681U heavy metal transport detoxification protein FOC12_23795 ENOG4105C59 p-type ATPase FOC12_23800 ENOG4105K70 DNA-binding protein FOC12_23805 ENOG4105TMB Formate nitrite transporter FOC12_23820 ENOG4105C85 amino acid FOC12_23830 ENOG4108SJC Membrane FOC12_23840 ENOG4105E98 transcriptional regulator DeoR family FOC12_23845 ENOG4105DE4 1-phosphofructokinase FOC12_23850 ENOG4105DM4 PTS System FOC12_23855 ENOG41069ER domain protein FOC12_23885 ENOG4106F1P AAA ATPase, central domain protein FOC12_23895 ENOG4105EN6 Membrane FOC12_23905 ENOG4105CXI aluminum resistance protein FOC12_23910 ENOG4105KV4 Transcriptional regulator FOC12_23915 ENOG4105C5F glutamine synthetase FOC12_24015 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC12_24195 ENOG4105XSJ toxin secretion phage lysis holin FOC12_24200 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC12_24230 ENOG4105K7K Transcriptional regulator FOC12_24250 ENOG4108SVB resolvase FOC12_24270 ENOG4105D5T phosphonate abc transporter FOC12_24285 ENOG4105D7V transposase FOC12_24305 ENOG4105BZ1 (ABC) transporter FOC12_24310 ENOG4105BZ1 (ABC) transporter FOC12_24325 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC12_24350 ENOG41067MG lrgb family FOC12_24355 ENOG4105VAW lrga family FOC12_24360 ENOG4107RSM transcriptional regulator FOC12_24370 ENOG4107QIV Cytochrome c biogenesis protein FOC12_24425 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC12_24450 ENOG4108903 Formimidoylglutamase FOC12_24455 ENOG4108VJ1 Transcriptional regulator (CarD family FOC12_24460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC12_24465 ENOG4105CBC glutamate synthase FOC12_24470 ENOG4105CK7 Sodium proline symporter FOC12_24475 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC12_24480 ENOG4105FBA Phospholipase Carboxylesterase FOC12_24485 ENOG4105BZU Histidine kinase FOC12_24495 ENOG4107AYK membrAne FOC12_24545 ENOG4105CEY Amp-dependent synthetase and ligase FOC12_24550 ENOG4107ZYJ bioY protein FOC12_24555 ENOG4107F3J Amp-dependent synthetase and ligase FOC12_24575 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC12_24615 ENOG4108I0Z Aconitate hydratase FOC12_24620 ENOG4108JJA ABC, transporter FOC12_24630 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC12_24635 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC12_24665 ENOG4105W8X HesB YadR YfhF-family protein FOC12_24670 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC12_24675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC12_24685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_24690 ENOG4105C0H protease FOC12_24695 ENOG4105K4P CoA-binding domain protein FOC12_24700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC12_24710 ENOG4105D9R oxidoreductase FOC12_24720 ENOG4105CIG ABC transporter FOC12_24735 ENOG4105EMN RNA polymerase sigma factor FOC12_24745 ENOG4108KGH TRANSCRIPTIONal FOC12_24810 ENOG4105E1K spore germination protein FOC12_24815 ENOG4108JB9 formate dehydrogenase FOC12_24825 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC12_24830 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC12_24840 ENOG4105TMB Formate nitrite transporter FOC12_24845 ENOG4105D06 uba thif-type nad fad binding protein FOC12_24850 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC12_24855 ENOG4108ZAF Molybdopterin FOC12_24865 ENOG4105D1F ATP-binding protein FOC12_24880 ENOG410696E Membrane FOC12_24885 ENOG4105FR1 rard protein FOC12_24895 ENOG4105EWU Squalene--hopene cyclase FOC12_24905 ENOG4105CHR reductase FOC12_24910 ENOG4105C26 Dehydrogenase FOC12_24920 ENOG4108IA2 Sodium pantothenate symporter FOC12_24935 ENOG4106IQC argininosuccinate lyase FOC12_24945 ENOG410904N short-chain dehydrogenase reductase FOC12_24965 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC12_24985 ENOG4105VEQ Cold shock protein FOC12_25000 ENOG4108R1P FOC12_25010 ENOG41073R8 VanW family FOC12_25015 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_25030 ENOG4105KT7 mgtC SapB transporter FOC12_25040 ENOG4105E39 Enoyl-CoA hydratase FOC12_25045 ENOG4105K64 Glycosyl transferase, family 2 FOC12_25055 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC12_25075 ENOG4105CQB FAD linked oxidase domain protein FOC12_25080 ENOG4105C09 Bile acid FOC12_25090 ENOG4105RHY Pfam:UPF0157 FOC12_25115 ENOG4105CIS alcohol dehydrogenase FOC12_25120 ENOG41082BM Transcriptional regulator, arsr family FOC12_25145 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC12_25175 ENOG4108A04 Beta-lactamase FOC12_25180 ENOG4105DPN Oligoendopeptidase f FOC12_25190 ENOG4105E5K Alpha-amylase FOC12_25200 ENOG4105C98 muts2 protein FOC12_25220 ENOG4107V2S Transcriptional regulator FOC12_25230 ENOG4107CUJ Protein of unknown function (DUF2690) FOC12_25250 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC12_25255 ENOG4105NX3 Membrane FOC12_25260 ENOG4105DQ5 transport system permease protein FOC12_25265 ENOG4105EHG Permease protein FOC12_25270 ENOG4108MES Periplasmic binding protein FOC12_25290 ENOG4107R3E Citrate transporter FOC12_25300 ENOG4108TN2 lmbE family FOC12_25370 ENOG4105H3G oxidoreductase FOC12_25380 ENOG4105ED2 Beta-lactamase FOC12_25405 ENOG4107YXZ hydrolase, family 25 FOC12_25420 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC12_25445 ENOG4105KAF membrAne FOC12_25515 ENOG4105KVH Transcriptional regulator FOC12_25535 ENOG4105CHR reductase FOC12_25545 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC12_25580 ENOG4105KVH Transcriptional regulator FOC12_25585 ENOG4105KVH Transcriptional regulator FOC12_25590 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC12_25600 ENOG4108TZY GntR Family Transcriptional Regulator FOC12_25605 ENOG4105KVH Transcriptional regulator FOC12_25635 ENOG4105C44 Serine transporter FOC12_25640 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC12_25655 ENOG4105F27 Major Facilitator FOC12_25660 ENOG4105CV8 reductase FOC12_25680 ENOG4105D4Y metalloprotease FOC12_25685 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC12_25700 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC12_25705 ENOG4105CIS alcohol dehydrogenase FOC12_25710 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC12_25715 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC12_25730 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC12_25735 ENOG4105C6Z Gluconate FOC12_25740 ENOG4105CMG Carbohydrate kinase FOC12_25745 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC12_25750 ENOG4105XDF Protein of unknown function (DUF1272) FOC12_25755 ENOG4105DDN Pentapeptide repeat-containing protein FOC12_25770 ENOG4105C37 (CBS) domain FOC12_25800 ENOG4105EV4 Multidrug resistance protein mdtH FOC12_25810 ENOG4105DMQ Methyltransferase FOC12_25830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC12_25835 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC12_25840 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC12_25850 ENOG4108UW5 maltose o-acetyltransferase FOC12_25855 ENOG4106UW1 Major Facilitator superfamily FOC12_25860 ENOG4105DKQ ROK family FOC12_25865 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_25925 ENOG4105CJ1 ABC, transporter FOC12_25935 ENOG4108PSK reductase FOC12_25955 ENOG4108RCM Nitroreductase FOC12_25960 ENOG4105KVH Transcriptional regulator FOC12_25975 ENOG4105CUT histidyl-tRNA synthetase FOC12_25980 ENOG4108Z66 YbaK ebsC protein FOC12_25990 ENOG41067QW Transcriptional regulator FOC12_26005 ENOG4108K8S endonuclease I FOC12_26030 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC12_26035 ENOG4108JJB ABC transporter FOC12_26065 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC12_26075 ENOG4105CRW Short chain fatty acid transporter FOC12_26085 ENOG4105KBX Transcriptional regulator, TetR family FOC12_26090 ENOG4105KPY Small multidrug resistance protein FOC12_26095 ENOG4105RXJ FOC12_26105 ENOG41069JR FOC12_26110 ENOG4105DA5 (ABC) transporter FOC12_26130 ENOG4105CZM Major Facilitator FOC12_26135 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC12_26145 ENOG4108ISG Major Facilitator FOC12_26195 ENOG410874W AraC family transcriptional regulator FOC12_26200 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC12_26215 ENOG4108AEY RNA polymerase sigma factor FOC12_26235 ENOG4108JQ1 Dehydrogenase FOC12_26250 ENOG4105DVH amino acid FOC12_26260 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC12_26275 ENOG4108JPW Aminotransferase FOC12_26290 ENOG4105EJQ L-serine dehydratase FOC12_26295 ENOG4105C44 Serine transporter FOC12_26310 ENOG4108JGH Tetr family transcriptional regulator FOC12_26315 ENOG4105EQ0 Major Facilitator superfamily FOC12_26335 ENOG4107QJQ Mate efflux family protein FOC12_26365 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC12_26395 ENOG4105TRI Hydrolase FOC12_26425 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC12_26435 ENOG4106P55 Transcriptional regulator FOC12_26445 ENOG4107QR9 Iron-sulfur cluster binding protein FOC12_26450 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC12_26455 ENOG4105DJB Major Facilitator Superfamily FOC12_26460 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC12_26475 ENOG4108U05 Transcriptional regulator FOC12_26490 ENOG4105BZU Histidine kinase FOC12_26505 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC12_26510 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC12_26525 ENOG4105JQZ Methyltransferase FOC12_26530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC12_26540 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC12_26545 ENOG4108NNI Beta-lactamase domain-containing protein FOC12_26560 ENOG4105VZ8 Transcriptional regulator FOC12_26580 ENOG4105K6H D-cysteine desulfhydrase FOC12_26605 ENOG41062D9 Histidine kinase FOC12_26610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC12_26625 ENOG4105IIP Membrane FOC12_26635 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC12_26640 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC12_26715 ENOG4108YXU transcriptional regulator AsnC family FOC12_26720 ENOG4105CHR reductase FOC12_26730 ENOG4105F7F Chaperone FOC12_26745 ENOG41085FC arsR family transcriptional regulator FOC12_26750 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC12_26755 ENOG4105D6J arsenicaL-resistance protein FOC12_26785 ENOG4105DIK (ABC) transporter FOC12_26790 ENOG4105CC5 ABC transporter FOC12_26795 ENOG4105DSE periplasmic solute binding protein FOC12_26800 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC12_26805 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC12_26820 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC12_26825 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC12_26840 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC12_26845 ENOG4108606 TspO/MBR family FOC12_26880 ENOG41090MY MarR family Transcriptional regulator FOC12_26905 ENOG4105CHJ isochorismatase hydrolase FOC12_26915 ENOG4105CH6 catalase FOC12_26920 ENOG4105CGH 5'-nucleotidase FOC12_26955 ENOG4105CSV Glutaminase FOC12_26990 ENOG4105C6K Malic enzyme FOC12_27000 ENOG4105II7 pyrroline-5-carboxylate reductase FOC12_27010 ENOG4105CUB amino acid FOC12_27015 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC12_27025 ENOG4108IMY Transcriptional regulator FOC12_27030 ENOG4105HDK L-asparaginase FOC12_27035 ENOG4108IJ0 Aspartate ammonia-lyase FOC12_27050 ENOG4105E2A Dehydrogenase