locus-tag class description FOC13_00010 ENOG41068WN FOC13_00045 ENOG4105F6J Alpha beta hydrolase fold FOC13_00065 ENOG4105CYC Transferase FOC13_00070 ENOG4105DY9 regulatoR FOC13_00080 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC13_00085 ENOG4105C6X Major Facilitator FOC13_00110 ENOG4105C7B Threonine dehydratase FOC13_00120 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC13_00125 ENOG4108ZP8 Acetolactate synthase small subunit FOC13_00130 ENOG4105C7K acetolactate synthase FOC13_00135 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC13_00140 ENOG4105CHR reductase FOC13_00145 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC13_00160 ENOG4106KE4 Dehydrogenase FOC13_00175 ENOG4105H67 Protein of unknown function (DUF421) FOC13_00180 ENOG4105X5K response regulator receiver protein FOC13_00190 ENOG4105C8J )-transporter FOC13_00210 ENOG4105C6T cysteine synthase FOC13_00215 ENOG4105EU0 Major facilitator Superfamily FOC13_00245 ENOG4105CSR polyphosphate kinase 2 FOC13_00285 ENOG4105FVX FOC13_00345 ENOG4105C6K Malic enzyme FOC13_00350 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_00360 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC13_00380 ENOG4105CJ1 ABC, transporter FOC13_00415 ENOG4106BRA Membrane FOC13_00445 ENOG4107QIV Cytochrome c biogenesis protein FOC13_00465 ENOG4105EC3 peptidase S51, dipeptidase E FOC13_00490 ENOG4105C9Q fumarate hydratase class II FOC13_00495 ENOG4105DFD Na H antiporter FOC13_00510 ENOG4108PJD permease FOC13_00515 ENOG4105CKI cobalamin synthesis protein FOC13_00520 ENOG4108UZ3 Transporter FOC13_00525 ENOG4105DRR Transcriptional regulator, GntR family FOC13_00535 ENOG4105PGM cation diffusion facilitator family transporter FOC13_00555 ENOG4105CAQ asparagine synthetase FOC13_00585 ENOG4105CVJ phosphoglycerate mutase FOC13_00625 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC13_00630 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC13_00635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC13_00640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_00645 ENOG4105DUM transcriptional regulator, lysR family FOC13_00670 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC13_00690 ENOG4108RZE Tetr family transcriptional regulator FOC13_00715 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_00720 ENOG4105KTQ flagellar basal-body rod protein FOC13_00730 ENOG4105D7B Flagellar biosynthesis protein flha FOC13_00735 ENOG4105D00 flagellar biosynthetic protein flhB FOC13_00745 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC13_00750 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC13_00760 ENOG4105DD5 Flagellar motor switch protein FOC13_00775 ENOG4105E4C Lytic transglycosylase catalytic FOC13_00780 ENOG4105I03 Flagellin FOC13_00815 ENOG4105K64 Glycosyl transferase, family 2 FOC13_00840 ENOG4105BZE flagellar hook protein, FlgE FOC13_00875 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC13_00885 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC13_00890 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC13_00895 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC13_00920 ENOG4105E1Q flagellar hook-associated protein FOC13_00940 ENOG4105BZU Histidine kinase FOC13_00955 ENOG4105DD5 Flagellar motor switch protein FOC13_00965 ENOG4107YTP response regulator receiver protein FOC13_00970 ENOG4105ER2 Ompa motb domain protein FOC13_00975 ENOG4107R0U MotA TolQ exbB proton channel FOC13_00985 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC13_01040 ENOG41080C8 DUF218 domain FOC13_01045 ENOG4105H67 Protein of unknown function (DUF421) FOC13_01055 ENOG4108Z5V transcriptional regulator, merr family FOC13_01065 ENOG4107RWR Sodium hydrogen exchanger FOC13_01075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_01140 ENOG41081VK Ribonuclease FOC13_01160 ENOG4108SZE gCN5-related N-acetyltransferase FOC13_01260 ENOG4105KHC sulfurtransferase FOC13_01270 ENOG4108W0I acetyltransferase FOC13_01280 ENOG410890F Dynamin family FOC13_01285 ENOG4105DHF Membrane FOC13_01290 ENOG4105C2W permease FOC13_01305 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_01320 ENOG4105CTD carboxy-peptidase FOC13_01325 ENOG4105DVT helicase FOC13_01335 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC13_01390 ENOG4105BZ4 penicillin-binding protein FOC13_01400 ENOG4105CSM endonuclease III FOC13_01420 ENOG4105YAC FOC13_01425 ENOG4105DVT helicase FOC13_01460 ENOG4105CPK Glycosyl transferase (Group 1 FOC13_01465 ENOG4105FJR Lmbe family FOC13_01480 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC13_01485 ENOG4108JYZ YitT family FOC13_01515 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC13_01520 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC13_01525 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC13_01540 ENOG41068YB TPR repeat-containing protein FOC13_01545 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC13_01565 ENOG4105EAH synthase FOC13_01575 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC13_01590 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC13_01620 ENOG41065D1 FOC13_01625 ENOG4105S2F FOC13_01660 ENOG4105HDK L-asparaginase FOC13_01665 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC13_01690 ENOG4108S6Z Negative regulator of genetic competence FOC13_01695 ENOG4107X2D transcriptional regulator, merr family FOC13_01710 ENOG4105I7S Abortive infection protein FOC13_01715 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC13_01720 ENOG4105T7X FOC13_01730 ENOG4108SAX Membrane FOC13_01745 ENOG4108WBT adenosyltransferase FOC13_01750 ENOG4105BZU Histidine kinase FOC13_01755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_01760 ENOG4105CRE cytochrome C FOC13_01765 ENOG4107TWT Cytochrome c biogenesis protein FOC13_01775 ENOG4105FE9 pseudouridine synthase FOC13_01785 ENOG4108JIC nucleoside recognition domain protein FOC13_01790 ENOG4105DZ1 carboxypeptidase FOC13_01795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_01830 ENOG4105BZU Histidine kinase FOC13_01845 ENOG4105I3N Conserved Protein FOC13_01865 ENOG4105BZ4 penicillin-binding protein FOC13_01870 ENOG4107GRR phosphate transport regulator FOC13_01875 ENOG4105CJ3 phosphate transporter FOC13_01895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC13_01920 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC13_01940 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_01945 ENOG4105ENE Histidine kinase FOC13_01965 ENOG4105DFD Na H antiporter FOC13_01985 ENOG4105C8J )-transporter FOC13_01990 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC13_01995 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC13_02000 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC13_02010 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC13_02015 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC13_02035 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC13_02045 ENOG4105E0M Sulfatase FOC13_02050 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC13_02065 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC13_02100 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC13_02125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC13_02135 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC13_02140 ENOG4108ZP8 Acetolactate synthase small subunit FOC13_02145 ENOG4105C7K acetolactate synthase FOC13_02150 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC13_02175 ENOG4105KBJ sporulation protein ytfj FOC13_02180 ENOG41063Y9 FOC13_02185 ENOG4105CZN Potassium uptake protein FOC13_02215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_02220 ENOG4107QMU Mate efflux family protein FOC13_02245 ENOG4105NQC Flavodoxin FOC13_02265 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_02275 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC13_02280 ENOG4105EA8 2-Nitropropane dioxygenase FOC13_02285 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC13_02325 ENOG4105CJ1 ABC, transporter FOC13_02335 ENOG4105CZV ABC transporter FOC13_02340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC13_02345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC13_02365 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC13_02400 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC13_02405 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC13_02415 ENOG4105BZU Histidine kinase FOC13_02420 ENOG4106DF1 FOC13_02430 ENOG41090MY MarR family Transcriptional regulator FOC13_02435 ENOG4105BZU Histidine kinase FOC13_02445 ENOG4105PXI polysaccharide deacetylase FOC13_02465 ENOG4105E98 transcriptional regulator DeoR family FOC13_02480 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC13_02495 ENOG4105C4Y ABC transporter FOC13_02510 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC13_02520 ENOG4105CHR reductase FOC13_02540 ENOG4108Z7G MaoC domain protein dehydratase FOC13_02545 ENOG410681C small acid-soluble spore protein FOC13_02550 ENOG4105CZN Potassium uptake protein FOC13_02555 ENOG4107TS3 membrane protein, TerC FOC13_02560 ENOG4108QTI )-transporter FOC13_02570 ENOG4106A3R peptidase FOC13_02590 ENOG4105JXH GntR family transcriptional regulator FOC13_02595 ENOG4105BZU Histidine kinase FOC13_02600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_02615 ENOG4105CQB FAD linked oxidase domain protein FOC13_02620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC13_02625 ENOG4105K4I Scp-like extracellular FOC13_02635 ENOG4108YBP pseudouridine synthase FOC13_02645 ENOG4105EYF MMPL domain protein FOC13_02655 ENOG4107RUE extracellular solute-binding protein family 1 FOC13_02660 ENOG4105D38 putrescine abc transporter FOC13_02665 ENOG4105F38 ABC transporter, permease FOC13_02670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_02675 ENOG4105C26 Dehydrogenase FOC13_02710 ENOG4105VFR signal peptidase FOC13_02715 ENOG4105DZ1 carboxypeptidase FOC13_02725 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC13_02785 ENOG4105VZ8 Transcriptional regulator FOC13_02795 ENOG4105C7S Dehydrogenase FOC13_02890 ENOG4105DDQ anthranilate synthase FOC13_02900 ENOG4105CK7 Sodium proline symporter FOC13_02925 ENOG4108WVJ 2'-5' rna ligase FOC13_02975 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC13_02985 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC13_02990 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC13_03010 ENOG4107TVC Glycosyl transferase, family 2 FOC13_03030 ENOG4105K64 Glycosyl transferase, family 2 FOC13_03050 ENOG4105EMS pseudouridine synthase FOC13_03055 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC13_03070 ENOG4105MIX Adenylate cyclase FOC13_03075 ENOG4108Z18 K06886 hemoglobin FOC13_03085 ENOG4105DPN Oligoendopeptidase f FOC13_03095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_03105 ENOG4108ZCF integral membrane protein FOC13_03125 ENOG4105UQX Mate efflux family protein FOC13_03130 ENOG4108JQ7 (ABC) transporter FOC13_03140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_03145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_03160 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC13_03175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC13_03180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_03205 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC13_03215 ENOG4108KP7 hydrolase FOC13_03225 ENOG41073B9 FOC13_03230 ENOG4107AYK membrAne FOC13_03240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_03250 ENOG4105QNR S1 RNA binding domain protein FOC13_03275 ENOG4105CH6 catalase FOC13_03280 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC13_03285 ENOG4105CAQ asparagine synthetase FOC13_03310 ENOG4105ERH Fumarylacetoacetate hydrolase FOC13_03355 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC13_03360 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC13_03375 ENOG4105XVF Competence transcription factor FOC13_03390 ENOG4105VEQ Cold shock protein FOC13_03405 ENOG4107QP3 malate synthase g FOC13_03410 ENOG4105ZU5 s-layer protein FOC13_03430 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_03435 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC13_03460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_03475 ENOG41086D8 Transcriptional regulator FOC13_03480 ENOG4108AEY RNA polymerase sigma factor FOC13_03490 ENOG4107TVP HD domain protein FOC13_03525 ENOG4105CNA YD repeat protein FOC13_03555 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_03565 ENOG4105DF9 Lipoate-protein, ligase FOC13_03570 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC13_03575 ENOG4106AXD FOC13_03605 ENOG4105ECB domain protein FOC13_03620 ENOG4105NA0 Transcriptional regulator FOC13_03645 ENOG4105C1Q protoporphyrinogen oxidase FOC13_03655 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC13_03660 ENOG4105BZ4 penicillin-binding protein FOC13_03665 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC13_03670 ENOG4105CKV Membrane FOC13_03675 ENOG410905X membrane-flanked domain protein FOC13_03720 ENOG410905X membrane-flanked domain protein FOC13_03750 ENOG4105K59 histidine triad (HIT) protein FOC13_03775 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_03780 ENOG4105EEM helicase FOC13_03790 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_03795 ENOG4105C57 major facilitator superfamily FOC13_03820 ENOG4105EMN RNA polymerase sigma factor FOC13_03830 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC13_03845 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC13_03865 ENOG4108MUZ hydrolase FOC13_03885 ENOG4105EQ0 Major Facilitator superfamily FOC13_03890 ENOG4108IND Tetr family transcriptional regulator FOC13_03905 ENOG4105D7V transposase FOC13_03915 ENOG4107VRP DNA repair exonuclease FOC13_03945 ENOG4105K8R UPF0145 protein FOC13_03965 ENOG4105BZU Histidine kinase FOC13_03970 ENOG4105BZU Histidine kinase FOC13_03975 ENOG4108MJI response regulator FOC13_03985 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_03995 ENOG4105WN5 stage II sporulation protein FOC13_04060 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC13_04090 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC13_04095 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC13_04100 ENOG4105CMT Dihydroxyacetone kinase FOC13_04110 ENOG4105CMT Dihydroxyacetone kinase FOC13_04130 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC13_04150 ENOG4108IG5 Transcriptional regulator FOC13_04155 ENOG4107P5I polyketide synthase FOC13_04200 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_04230 ENOG4105CDU Replicative dna helicase FOC13_04280 ENOG4108MRH transcriptional regulatory protein FOC13_04290 ENOG4105CSH Transporter FOC13_04320 ENOG4105PKS Excinuclease abc c subunit domain protein FOC13_04325 ENOG4108JQ7 (ABC) transporter FOC13_04335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_04375 ENOG4105CTU Proline racemase FOC13_04395 ENOG4105DER m42 family FOC13_04415 ENOG4105CGU Enoyl-CoA hydratase FOC13_04430 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_04435 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC13_04445 ENOG4106AKK s-layer domain-containing protein FOC13_04485 ENOG4105CHH sulfate transporter FOC13_04500 ENOG4105D4P Coproporphyrinogen iii oxidase FOC13_04530 ENOG4107FQX Alpha-acetolactate decarboxylase FOC13_04565 ENOG410839P FOC13_04580 ENOG4105CDA abc transporter atp-binding protein FOC13_04585 ENOG4105DRP amino acid AbC transporter FOC13_04600 ENOG4105BZ1 (ABC) transporter FOC13_04605 ENOG4105C26 Dehydrogenase FOC13_04615 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC13_04620 ENOG4105D5Q Arginine ornithine antiporter FOC13_04630 ENOG4105CH6 catalase FOC13_04635 ENOG4107RKG DJ-1/PfpI family FOC13_04645 ENOG4105E5W Transporter FOC13_04650 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC13_04655 ENOG4105NF4 modulator of drug activity FOC13_04680 ENOG4105KPY Small multidrug resistance protein FOC13_04685 ENOG4105KPY Small multidrug resistance protein FOC13_04695 ENOG4108YXU transcriptional regulator AsnC family FOC13_04700 ENOG4108PCN EamA-like transporter family FOC13_04735 ENOG4106KNT transcriptional regulator FOC13_04745 ENOG4107RWR Sodium hydrogen exchanger FOC13_04750 ENOG4105CUB amino acid FOC13_04780 ENOG4107T5V SNARE associated Golgi FOC13_04815 ENOG4105WEF catalase FOC13_04845 ENOG4105C19 ABC transporter FOC13_04850 ENOG4107RBB ABC transporter, permease FOC13_04855 ENOG41069ER domain protein FOC13_04875 ENOG4105VZJ PTS System FOC13_04880 ENOG4105VCP PTS System FOC13_04885 ENOG4105EMD TRANSCRIPTIONal FOC13_04910 ENOG4108KGH TRANSCRIPTIONal FOC13_04920 ENOG41087NI Sulfite exporter TauE/SafE FOC13_04925 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC13_04935 ENOG41085GJ domain protein FOC13_04940 ENOG4105VFE sira family FOC13_04945 ENOG4107TPS domain protein FOC13_04950 ENOG4105VFE sira family FOC13_04955 ENOG4105XTG Pfam:DUF156 FOC13_04960 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC13_04985 ENOG4105ED1 spovr family FOC13_04990 ENOG4107Y03 Nitroreductase FOC13_05045 ENOG4105C5Y PTS System FOC13_05075 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_05090 ENOG4108INS Transcriptional regulator FOC13_05140 ENOG4105DWF phosphomethylpyrimidine kinase FOC13_05145 ENOG4105D06 uba thif-type nad fad binding protein FOC13_05160 ENOG41080HI glycine oxidase FOC13_05165 ENOG4108VEU Thiamine monophosphate synthase FOC13_05175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC13_05185 ENOG4105ETU transcriptional activator (TenA FOC13_05205 ENOG41080XQ Signal transduction protein with cbs domains FOC13_05330 ENOG4105E2Z phosphate ABC transporter (Permease FOC13_05335 ENOG4105C8U phosphate abc transporter FOC13_05340 ENOG4105CVA phosphate FOC13_05345 ENOG4105CE1 Ferrous iron transport protein b FOC13_05350 ENOG4105CE1 Ferrous iron transport protein b FOC13_05355 ENOG4105CE1 Ferrous iron transport protein b FOC13_05360 ENOG4108NHD germination protein FOC13_05375 ENOG4105E1V na solute symporter FOC13_05380 ENOG4106CAD Protein of unknown function (DUF3311) FOC13_05395 ENOG4108IQI permease FOC13_05400 ENOG4105E2S oxidase) subunit II FOC13_05405 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC13_05445 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_05450 ENOG4105C85 amino acid FOC13_05470 ENOG4105DUX Transporter FOC13_05480 ENOG4107D63 FOC13_05485 ENOG4105VZ8 Transcriptional regulator FOC13_05490 ENOG41069ER domain protein FOC13_05495 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC13_05500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_05560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC13_05565 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC13_05570 ENOG4105CNN ABC, transporter FOC13_05585 ENOG4108RVA ribokinase FOC13_05590 ENOG4105ETE Transcriptional regulator (LacI family FOC13_05600 ENOG41067TZ transcriptional regulator, MarR family FOC13_05605 ENOG4105CXY transporter FOC13_05615 ENOG4108JQ7 (ABC) transporter FOC13_05620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_05630 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC13_05640 ENOG41068KF Universal stress protein FOC13_05645 ENOG4105CHH sulfate transporter FOC13_05660 ENOG4105BZU Histidine kinase FOC13_05665 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC13_05670 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC13_05695 ENOG4108IQI permease FOC13_05700 ENOG4105DRP amino acid AbC transporter FOC13_05705 ENOG4105EAD ABC transporter FOC13_05710 ENOG4105CT1 (ABC) transporter FOC13_05715 ENOG4105CDA abc transporter atp-binding protein FOC13_05720 ENOG4105BZG amino acid carrier protein FOC13_05725 ENOG4105CRN Aminoglycoside phosphotransferase FOC13_05735 ENOG4105E1K spore germination protein FOC13_05750 ENOG4105CG3 alpha amylase, catalytic region FOC13_05755 ENOG4105C5Y PTS System FOC13_05760 ENOG4107414 GntR family transcriptional regulator FOC13_05765 ENOG4105D5Q Arginine ornithine antiporter FOC13_05770 ENOG4105BZU Histidine kinase FOC13_05785 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_05790 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC13_05795 ENOG4107T89 von Willebrand factor, type A FOC13_05805 ENOG4105EXW epimerase dehydratase FOC13_05815 ENOG4105DMQ Methyltransferase FOC13_05820 ENOG4105E0A ABC, transporter FOC13_05825 ENOG4108IHU transport system permease protein FOC13_05830 ENOG4105DQ5 transport system permease protein FOC13_05835 ENOG4108MES Periplasmic binding protein FOC13_05840 ENOG4105DUX Transporter FOC13_05855 ENOG4105DAA L-lactate FOC13_05860 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_05865 ENOG4105C37 (CBS) domain FOC13_05870 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC13_05875 ENOG4105D9N nucleoside FOC13_05880 ENOG4108KGH TRANSCRIPTIONal FOC13_05885 ENOG41073R8 VanW family FOC13_05920 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC13_05925 ENOG4105C59 p-type ATPase FOC13_05935 ENOG4105CUB amino acid FOC13_05955 ENOG4108JB9 formate dehydrogenase FOC13_05960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC13_05965 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC13_05970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_05975 ENOG4105BZU Histidine kinase FOC13_05985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC13_05990 ENOG4108UZ3 Transporter FOC13_06000 ENOG4105C6K Malic enzyme FOC13_06010 ENOG4108MRH transcriptional regulatory protein FOC13_06035 ENOG4105US7 Histidine kinase FOC13_06040 ENOG4108STX response regulator FOC13_06045 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC13_06050 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC13_06055 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC13_06060 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC13_06065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC13_06070 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC13_06090 ENOG4105D4T Citrate transporter FOC13_06100 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC13_06110 ENOG4105DZ6 Band 7 protein FOC13_06125 ENOG4105C94 Transporter FOC13_06145 ENOG4105CYN Serine protein kinase FOC13_06150 ENOG4105BZU Histidine kinase FOC13_06155 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC13_06165 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC13_06175 ENOG4107ZQN disulfide bond FOC13_06180 ENOG4108JQC penicillin-binding protein 1A FOC13_06295 ENOG4105G5W regulator Fur family FOC13_06300 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC13_06320 ENOG4108IUW ABC transporter FOC13_06330 ENOG4105CBC glutamate synthase FOC13_06335 ENOG4107NBY Membrane FOC13_06340 ENOG4105BZ1 (ABC) transporter FOC13_06360 ENOG4106BXE FOC13_06365 ENOG4105CEN a g-specific adenine glycosylase FOC13_06370 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC13_06400 ENOG4105ECP epimerase FOC13_06405 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC13_06425 ENOG4105F1A Pyruvate formate-lyase FOC13_06445 ENOG4105C3I Nad-dependent epimerase dehydratase FOC13_06450 ENOG4107QQG Dehydrogenase FOC13_06460 ENOG4105CKK Glycosyl transferase, family 2 FOC13_06475 ENOG4108A04 Beta-lactamase FOC13_06485 ENOG4105CSV Glutaminase FOC13_06510 ENOG4108IQI permease FOC13_06520 ENOG4108JUB Transcriptional regulator FOC13_06530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC13_06785 ENOG4108IMY Transcriptional regulator FOC13_06790 ENOG4105VTR Integrase FOC13_06795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC13_06835 ENOG4105UPD Calcium Proton FOC13_06840 ENOG410606W general stress protein FOC13_06855 ENOG4107ZTW SNARE associated Golgi FOC13_06875 ENOG4108IPJ Membrane FOC13_06880 ENOG4105C59 p-type ATPase FOC13_06885 ENOG4107U9T Pfam:Ribonuclease_BN FOC13_06895 ENOG4105KJF protein tyrosine phosphatase FOC13_06915 ENOG4108TTB tellurium resistance protein FOC13_06920 ENOG4107TS3 membrane protein, TerC FOC13_06925 ENOG4106FN3 tellurium resistance protein FOC13_06930 ENOG4106FN3 tellurium resistance protein FOC13_06935 ENOG4108N0M stress protein FOC13_06950 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC13_06965 ENOG4105DEU major facilitator superfamily FOC13_06985 ENOG41062JF Transcriptional regulator FOC13_07010 ENOG4105C5H ABC transporter FOC13_07025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC13_07040 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC13_07070 ENOG4105CI1 PTS System FOC13_07080 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_07085 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_07095 ENOG4105EAB amino acid AbC transporter FOC13_07100 ENOG4105E5Q amino acid AbC transporter FOC13_07115 ENOG4105D2S major facilitator superfamily FOC13_07120 ENOG410756H nucleotidyltransferase FOC13_07140 ENOG4105BZU Histidine kinase FOC13_07165 ENOG4106UIA FOC13_07170 ENOG4106UIA FOC13_07190 ENOG4108V5C ABC transporter FOC13_07195 ENOG4105DQ5 transport system permease protein FOC13_07200 ENOG4105EHG Permease protein FOC13_07205 ENOG4107W7X Aldolase FOC13_07215 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC13_07220 ENOG4105D3R alkyl hydroperoxide reductase FOC13_07240 ENOG4105DFD Na H antiporter FOC13_07250 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_07265 ENOG4108W15 Protein of unknown function (DUF1456) FOC13_07280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC13_07285 ENOG4105D9N nucleoside FOC13_07305 ENOG4105KPY Small multidrug resistance protein FOC13_07310 ENOG4105C26 Dehydrogenase FOC13_07320 ENOG4108JPW Aminotransferase FOC13_07325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC13_07330 ENOG4105CBD Diacylglycerol kinase FOC13_07355 ENOG410834F Transcriptional regulator FOC13_07375 ENOG4105D01 (LipO)protein FOC13_07380 ENOG4108UMI ABC transporter, permease FOC13_07385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_07390 ENOG4108W2Y isochorismatase FOC13_07415 ENOG4105C4R Atp-dependent dna helicase FOC13_07440 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC13_07450 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC13_07475 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC13_07485 ENOG4105C83 adenylosuccinate lyase FOC13_07490 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC13_07495 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC13_07515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_07535 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC13_07575 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_07610 ENOG4105BZU Histidine kinase FOC13_07620 ENOG4105C7N Xanthine uracil vitamin C permease FOC13_07640 ENOG4108TYN CAAX amino terminal protease family protein FOC13_07655 ENOG4105C5H ABC transporter FOC13_07660 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC13_07665 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC13_07670 ENOG41072GX Peptidase M22 Glycoprotease FOC13_07675 ENOG4105K8N protein family UPF0079, ATPase FOC13_07775 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC13_07785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC13_07790 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC13_07800 ENOG4107ZXI Rhomboid family FOC13_07815 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC13_07825 ENOG4108SC4 )-transporter FOC13_07835 ENOG4105ERH Fumarylacetoacetate hydrolase FOC13_07840 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC13_07860 ENOG4108JQ7 (ABC) transporter FOC13_07865 ENOG4105C3U ABC transporter FOC13_07870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_07880 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC13_07895 ENOG4105C5H ABC transporter FOC13_07915 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC13_07920 ENOG4108RE7 deoxyribonuclease FOC13_07930 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC13_07950 ENOG4105F6E Acyl-transferase FOC13_07970 ENOG4105EGI Transcriptional regulator FOC13_07980 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC13_07990 ENOG4105E0C molybdate abc transporter FOC13_08000 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC13_08005 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_08015 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC13_08020 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC13_08050 ENOG4108JQ7 (ABC) transporter FOC13_08055 ENOG4105C3U ABC transporter FOC13_08060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_08065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC13_08080 ENOG4105C2C drug resistance transporter, Bcr CflA FOC13_08095 ENOG4105IQ5 FAD linked oxidase domain protein FOC13_08105 ENOG4105EE1 crotonyl-CoA reductase FOC13_08110 ENOG4105D01 (LipO)protein FOC13_08115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_08120 ENOG4108UMI ABC transporter, permease FOC13_08155 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC13_08160 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC13_08180 ENOG4108VQT Alpha beta hydrolase fold protein FOC13_08185 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC13_08200 ENOG4107U5W ybbr family FOC13_08205 ENOG4105C8B TIGR00159 family FOC13_08285 ENOG4108NMV polysaccharide deacetylase FOC13_08300 ENOG4105D1F ATP-binding protein FOC13_08325 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC13_08330 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC13_08335 ENOG4108JJB ABC transporter FOC13_08365 ENOG41067V7 50S ribosomal protein L36 FOC13_08375 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_08385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC13_08410 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC13_08515 ENOG4105XPM ribosomal protein FOC13_08520 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC13_08530 ENOG4107Y49 methyltransferase FOC13_08555 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC13_08570 ENOG4105QIV RNA polymerase FOC13_08575 ENOG4105M0M Tetracycline resistance protein FOC13_08580 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC13_08595 ENOG4105D7W serine acetyltransferase FOC13_08615 ENOG4105CTP PilT protein domain protein FOC13_08625 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC13_08640 ENOG4108Z0C Uvrb UvrC protein FOC13_08670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC13_08680 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC13_08685 ENOG4105KRF dihydroneopterin aldolase FOC13_08690 ENOG4105EEI dihydropteroate synthase FOC13_08695 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC13_08700 ENOG4105DDQ anthranilate synthase FOC13_08705 ENOG4105CRQ synthase (Component I) FOC13_08710 ENOG4105C6T cysteine synthase FOC13_08725 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC13_08730 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC13_08735 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC13_08755 ENOG41060GV RNA binding s1 domain protein FOC13_08770 ENOG4105VYY sporulation protein yabp FOC13_08775 ENOG41082I2 s4 domain protein FOC13_08780 ENOG4108IY2 MazG family FOC13_08790 ENOG4108M14 stage v sporulation protein t FOC13_08795 ENOG4108JA2 transcriptioN-repair coupling factor FOC13_08805 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC13_08810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC13_08825 ENOG4105KME endoribonuclease L-psp FOC13_08830 ENOG4105DFT pur operon repressor FOC13_08845 ENOG4105W42 Veg protein FOC13_08850 ENOG4105XFA sporulation peptidase YabG FOC13_08860 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC13_08865 ENOG4105F8V Hydrolase, tatD family FOC13_08875 ENOG4105KRN Transcriptional regulator, abrb family FOC13_08880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC13_08890 ENOG41060K3 Methyltransferase FOC13_08900 ENOG4105MA4 psp1 domain protein FOC13_08905 ENOG4105FA2 dna polymerase iii FOC13_08915 ENOG4105CXN decarboxylase FOC13_08950 ENOG41067KS pro-sigma K processing FOC13_08970 ENOG4105C6E dna polymerase iii FOC13_08980 ENOG4108Z6B deaminase FOC13_08985 ENOG4105GTG Isochorismatase FOC13_08995 ENOG4105ZMH deoxynucleoside kinase FOC13_09030 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC13_09065 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC13_09080 ENOG410848D S4 domain protein YaaA FOC13_09085 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC13_09105 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC13_09115 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC13_09135 ENOG4107QJE Chromosome Partitioning Protein FOC13_09140 ENOG4105FA0 parb-like partition protein FOC13_09145 ENOG4108ZDA Sporulation protein YyaC FOC13_09150 ENOG4105D8X mechanosensitive ion channel FOC13_09155 ENOG4105VDK protein, conserved in bacteria FOC13_09160 ENOG4105C3G gtp-binding protein FOC13_09170 ENOG4108UUM single-stranded DNA-binding protein FOC13_09180 ENOG4108XMW Membrane FOC13_09185 ENOG4105BZR domain protein FOC13_09195 ENOG4105CDU Replicative dna helicase FOC13_09225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_09230 ENOG4105BZU Histidine kinase FOC13_09245 ENOG4105Q2H domain protein FOC13_09250 ENOG4105C0H protease FOC13_09270 ENOG4105DPN Oligoendopeptidase f FOC13_09285 ENOG4105C1J atp-dependent rna helicase FOC13_09295 ENOG4108UT2 hemolysin iii FOC13_09300 ENOG4105CMR udp-glucose 4-epimerase FOC13_09310 ENOG4105IW1 AmiS UreI transporter FOC13_09320 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_09335 ENOG4107RGD Major Facilitator superfamily FOC13_09340 ENOG4108HRK Histidine kinase FOC13_09345 ENOG4105DY9 regulatoR FOC13_09360 ENOG4106F5Q Membrane FOC13_09365 ENOG4105E0X reductase FOC13_09375 ENOG41067SE Tetr family transcriptional regulator FOC13_09380 ENOG4105CKK Glycosyl transferase, family 2 FOC13_09400 ENOG4105C5H ABC transporter FOC13_09405 ENOG4105JEU Glycosyl transferase, family 2 FOC13_09415 ENOG4108S4H thioesterase Superfamily protein FOC13_09425 ENOG4106YBV Methyl-accepting chemotaxis FOC13_09430 ENOG4105EN6 Membrane FOC13_09450 ENOG41079KZ Major Facilitator Superfamily FOC13_09455 ENOG4105DY9 regulatoR FOC13_09460 ENOG4105D22 carbon starvation protein FOC13_09465 ENOG4105VCD cytoplasmic protein FOC13_09470 ENOG4105BZU Histidine kinase FOC13_09475 ENOG4105DWF phosphomethylpyrimidine kinase FOC13_09485 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_09495 ENOG4108Y4K DNA-binding transcriptional activator FOC13_09520 ENOG4105D6E homoserine dehydrogenase FOC13_09535 ENOG41090WU lipolytic protein G-D-S-L family FOC13_09540 ENOG4105CJ1 ABC, transporter FOC13_09545 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC13_09555 ENOG4105VCH membrane FOC13_09560 ENOG410667J hydrolase FOC13_09590 ENOG4108VKI Cell wall hydrolase FOC13_09605 ENOG4108IJ2 phosphate acetyltransferase FOC13_09620 ENOG4108VCI transcription factor, rsfa family FOC13_09635 ENOG4105EHG Permease protein FOC13_09640 ENOG4105E0A ABC, transporter FOC13_09645 ENOG4108MES Periplasmic binding protein FOC13_09650 ENOG4105DCI Phosphohydrolase FOC13_09655 ENOG41069HH 4-oxalocrotonate tautomerase FOC13_09660 ENOG4108Z4T Peptidase M50 FOC13_09665 ENOG4108XFG YwhD family FOC13_09670 ENOG4105BZ4 penicillin-binding protein FOC13_09675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC13_09680 ENOG4107SWG transcriptional regulator MERR family FOC13_09685 ENOG4105DXB Major Facilitator superfamily FOC13_09695 ENOG4105CYW agmatinase FOC13_09715 ENOG410684U Domain of unknown function (DUF1934) FOC13_09725 ENOG4105EMN RNA polymerase sigma factor FOC13_09745 ENOG4105IIU Aminopeptidase FOC13_09755 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC13_09760 ENOG4108M15 ABC transporter FOC13_09765 ENOG4105KCT ABC transporter FOC13_09770 ENOG4105BZU Histidine kinase FOC13_09800 ENOG4105BZU Histidine kinase FOC13_09815 ENOG4105DF6 Fe-S oxidoreductase FOC13_09825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC13_09830 ENOG4105C1G acyl-Coa dehydrogenase FOC13_09835 ENOG4105C1G acyl-Coa dehydrogenase FOC13_09870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC13_09875 ENOG4105CBT Fructose-1,6-bisphosphatase FOC13_09880 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC13_09895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC13_09900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC13_09905 ENOG4108ZXQ stage ii sporulation protein r FOC13_09915 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC13_09930 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC13_09935 ENOG4108VGI doxx family FOC13_09950 ENOG4108YZG isomerase FOC13_09980 ENOG41062M3 atp synthase FOC13_09985 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC13_10035 ENOG4105BZU Histidine kinase FOC13_10040 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC13_10050 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC13_10055 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC13_10080 ENOG4105D65 subunit l FOC13_10085 ENOG4105C8S subunit m FOC13_10090 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC13_10095 ENOG4106778 Protein of unknown function (DUF1146) FOC13_10115 ENOG4108IUW ABC transporter FOC13_10120 ENOG4105DY9 regulatoR FOC13_10135 ENOG4105FRN stage II sporulation protein FOC13_10150 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC13_10205 ENOG4105EY8 ABC transporter FOC13_10210 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC13_10225 ENOG4105CMR udp-glucose 4-epimerase FOC13_10230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_10235 ENOG4105BZU Histidine kinase FOC13_10250 ENOG4105CXY transporter FOC13_10270 ENOG4105C19 ABC transporter FOC13_10275 ENOG4107RBB ABC transporter, permease FOC13_10285 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_10315 ENOG4105C0D helicase FOC13_10320 ENOG4105KBK Zinc finger, swim domain protein FOC13_10345 ENOG41069ER domain protein FOC13_10350 ENOG4105C94 Transporter FOC13_10380 ENOG4105E0M Sulfatase FOC13_10390 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC13_10400 ENOG4105DAA L-lactate FOC13_10440 ENOG4107RSM transcriptional regulator FOC13_10445 ENOG4105ECB domain protein FOC13_10450 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_10465 ENOG4105VZJ PTS System FOC13_10475 ENOG4105VCP PTS System FOC13_10480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC13_10485 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC13_10495 ENOG4105CK1 PTS System FOC13_10500 ENOG4105VCP PTS System FOC13_10505 ENOG4105F8D glycoside hydrolase family 4 FOC13_10510 ENOG410901P UPF0249 protein FOC13_10525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC13_10535 ENOG4105ESV Glycosyl transferase, family 4 FOC13_10540 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC13_10545 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC13_10550 ENOG4108KGH TRANSCRIPTIONal FOC13_10555 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC13_10565 ENOG4105KVH Transcriptional regulator FOC13_10580 ENOG41081UC Inherit from COG: Competence protein FOC13_10585 ENOG4105VEQ Cold shock protein FOC13_10590 ENOG4105MS2 ribosomal subunit Interface protein FOC13_10595 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC13_10615 ENOG4105CAK Cell division ATP-binding protein ftsE FOC13_10620 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC13_10625 ENOG4105CN1 protease FOC13_10635 ENOG4105BZ1 (ABC) transporter FOC13_10650 ENOG4108WS4 fmn reductase FOC13_10660 ENOG4105DUM transcriptional regulator, lysR family FOC13_10665 ENOG4105HMI Membrane FOC13_10690 ENOG4107TXC Transcriptional regulator FOC13_10705 ENOG4105D7V transposase FOC13_10710 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC13_10715 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_10725 ENOG41086DT Membrane protein of unknown function FOC13_10745 ENOG4108S4C acetyltransferase FOC13_10755 ENOG4105C3M thioredoxin reductase FOC13_10765 ENOG4108Z4K mutator MutT protein FOC13_10775 ENOG4105CHW UPF0052 protein FOC13_10785 ENOG4105KRI phosphocarrier protein (HPr FOC13_10790 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC13_10795 ENOG4105H67 Protein of unknown function (DUF421) FOC13_10810 ENOG4105CZ3 stage V sporulation protein ad FOC13_10815 ENOG41090VF Stage v sporulation protein ac FOC13_10835 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_10860 ENOG4105CP7 Triose-phosphate isomerase FOC13_10865 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC13_10875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC13_10900 ENOG4105EFC phage portal protein HK97 family FOC13_10995 ENOG41067MG lrgb family FOC13_11000 ENOG4105XZU Preprotein translocase, subunit SecG FOC13_11010 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC13_11040 ENOG4105CM4 permease protein FOC13_11045 ENOG4108IPW abc transporter atp-binding protein FOC13_11060 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC13_11065 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC13_11080 ENOG4105WMR Protein CrcB homolog FOC13_11085 ENOG4105WMR Protein CrcB homolog FOC13_11095 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_11105 ENOG4105D4A Cell wall formation (By similarity) FOC13_11110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC13_11125 ENOG4105KVH Transcriptional regulator FOC13_11130 ENOG4105F27 Major Facilitator FOC13_11135 ENOG4105CV8 reductase FOC13_11150 ENOG4108RYK Nad-dependent epimerase dehydratase FOC13_11165 ENOG4105D9N nucleoside FOC13_11170 ENOG4105D9N nucleoside FOC13_11190 ENOG4108URH decarboxylase FOC13_11205 ENOG4108RMU ferritin dps family protein FOC13_11215 ENOG4105NCW Trka-c domain protein FOC13_11220 ENOG4107S91 Sodium hydrogen exchanger FOC13_11240 ENOG4105D4Y metalloprotease FOC13_11245 ENOG4105VG1 fes assembly suf system protein FOC13_11260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC13_11270 ENOG4105BZU Histidine kinase FOC13_11275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_11280 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC13_11290 ENOG4107ZTW SNARE associated Golgi FOC13_11325 ENOG4107AYK membrAne FOC13_11335 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC13_11345 ENOG4107R7I amino acid FOC13_11350 ENOG4108SUT Major Facilitator Superfamily FOC13_11365 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC13_11385 ENOG4105DZ1 carboxypeptidase FOC13_11400 ENOG4105CHU acetyl-coa acetyltransferase FOC13_11405 ENOG4105C1G acyl-Coa dehydrogenase FOC13_11410 ENOG4108W8B Beta-lactamase domain protein FOC13_11435 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_11480 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC13_11515 ENOG4108UMI ABC transporter, permease FOC13_11520 ENOG4105D01 (LipO)protein FOC13_11525 ENOG4105D01 (LipO)protein FOC13_11530 ENOG4105C3K feS assembly ATPase SufC FOC13_11535 ENOG4105JRK feS assembly protein SufD FOC13_11540 ENOG4105C9B Cysteine desulfurase FOC13_11545 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC13_11550 ENOG4105DIW FeS assembly protein SUFB FOC13_11565 ENOG4107R8B 5'-nucleotidase FOC13_11570 ENOG4105KZD Domain of unknown function (DUF1805) FOC13_11580 ENOG4105FAA peptidase M23 FOC13_11605 ENOG41090T1 Membrane FOC13_11610 ENOG4107TXC Transcriptional regulator FOC13_11615 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC13_11620 ENOG4105MMD transcriptional regulator FOC13_11635 ENOG4105CBT Fructose-1,6-bisphosphatase FOC13_11650 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC13_11655 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC13_11665 ENOG4108W5N phosphatidylglycerophosphatase a FOC13_11680 ENOG41083MR nifu domain-containing protein FOC13_11725 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC13_11730 ENOG4105C4B ABC transporter, permease FOC13_11735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC13_11760 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC13_11780 ENOG4105EWC Purine nucleoside phosphorylase FOC13_11810 ENOG4105CEP NADH dehydrogenase FOC13_11825 ENOG41069ER domain protein FOC13_11845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC13_11865 ENOG4105KA0 thioesterase Superfamily protein FOC13_11870 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC13_11885 ENOG4107R3E Citrate transporter FOC13_11895 ENOG4105Y38 Kinase-associated protein B FOC13_11905 ENOG4105C87 Aminotransferase class I and II FOC13_11915 ENOG4108MUZ hydrolase FOC13_11920 ENOG4105C5I Dehydrogenase FOC13_11925 ENOG4108ZB6 transcriptional regulator AsnC family FOC13_11930 ENOG4105CHM Aminotransferase FOC13_11940 ENOG4105WG9 Conserved Protein FOC13_11945 ENOG4107QYV phosphohexose isomerase FOC13_11955 ENOG4107PBV potassium channel FOC13_11960 ENOG4105KT7 mgtC SapB transporter FOC13_11995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC13_12090 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_12110 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC13_12120 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC13_12140 ENOG4105VEQ Cold shock protein FOC13_12150 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC13_12155 ENOG4105E4F Isochorismate synthase FOC13_12160 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC13_12165 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC13_12170 ENOG4108IPT Naphthoate synthase FOC13_12180 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_12210 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC13_12230 ENOG4105FDP GntR family transcriptional regulator FOC13_12235 ENOG4105C6Z Gluconate FOC13_12275 ENOG41086D8 Transcriptional regulator FOC13_12280 ENOG4105C19 ABC transporter FOC13_12295 ENOG4107ZTW SNARE associated Golgi FOC13_12330 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC13_12335 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC13_12360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_12365 ENOG4105BZU Histidine kinase FOC13_12400 ENOG41087YS Phage shock protein A FOC13_12445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC13_12450 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC13_12455 ENOG4108V2W Carbonate dehydratase FOC13_12510 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC13_12520 ENOG4105D2X ABC transporter substrate-binding protein FOC13_12540 ENOG4107S9D Alpha beta hydrolase FOC13_12545 ENOG4105BZU Histidine kinase FOC13_12550 ENOG4105BZU Histidine kinase FOC13_12555 ENOG4105EGD dinuclear metal center protein, YbgI family FOC13_12605 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC13_12615 ENOG4105BZF Glycosyl transferase (Group 1 FOC13_12620 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC13_12625 ENOG4108Z0R Transferase FOC13_12630 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC13_12660 ENOG4105DA5 (ABC) transporter FOC13_12670 ENOG4105N5T Radical SAM Protein FOC13_12690 ENOG4105C19 ABC transporter FOC13_12705 ENOG4105NCW Trka-c domain protein FOC13_12710 ENOG4107S91 Sodium hydrogen exchanger FOC13_12715 ENOG410605W Major Facilitator FOC13_12745 ENOG4108B31 Spore germination protein FOC13_12755 ENOG4105DWV Homoserine O-trans-acetylase FOC13_12765 ENOG41085GJ domain protein FOC13_12790 ENOG4105D06 uba thif-type nad fad binding protein FOC13_12800 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_12805 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC13_12810 ENOG4108ZAF Molybdopterin FOC13_12825 ENOG4105CSC Glucose uptake protein FOC13_12830 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC13_12835 ENOG4108VJ1 Transcriptional regulator (CarD family FOC13_12870 ENOG4105CBX hi0933 family FOC13_12885 ENOG4105YW5 deoR family transcriptional regulator FOC13_12900 ENOG4108IUM Glycogen debranching enzyme FOC13_12905 ENOG4108V15 phosphotransferase enzyme family FOC13_12920 ENOG4105C8F Beta-lactamase domain protein FOC13_12950 ENOG4108VDD TRNA binding domain protein FOC13_12995 ENOG4105C88 aminopeptidase FOC13_13015 ENOG4105ETE Transcriptional regulator (LacI family FOC13_13045 ENOG4105EP9 oxidoreductase FOC13_13050 ENOG4107SNB ankyrin repeat protein YahD FOC13_13060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_13070 ENOG4105DGU Histone deacetylase FOC13_13075 ENOG4105W87 Cbs domain FOC13_13080 ENOG4105F1V Acetoin utilization protein FOC13_13100 ENOG4105EMN RNA polymerase sigma factor FOC13_13110 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC13_13130 ENOG4105C28 cystathionine FOC13_13150 ENOG4106KR7 LysR family Transcriptional regulator FOC13_13175 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC13_13185 ENOG4105EFZ amidohydrolase FOC13_13200 ENOG4105KBJ sporulation protein ytfj FOC13_13205 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC13_13215 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC13_13235 ENOG4108JYZ YitT family FOC13_13275 ENOG4107YZX Universal stress protein FOC13_13295 ENOG4105VZ8 Transcriptional regulator FOC13_13305 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC13_13310 ENOG4105Z7P Acetyltransferase (GNAT) family FOC13_13345 ENOG4105DC7 peptidase M24 FOC13_13380 ENOG4105SFS phosphoesterase RecJ domain protein FOC13_13390 ENOG4105VV2 FOC13_13395 ENOG4105C0B DNA polymerase III (alpha subunit) FOC13_13400 ENOG4105C6K Malic enzyme FOC13_13405 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC13_13430 ENOG4105FS0 cytoplasmic membrane protein FOC13_13435 ENOG4108REF Sporulation integral membrane protein ytvi FOC13_13445 ENOG4105BZN citrate synthase FOC13_13450 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC13_13465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_13470 ENOG4105BZU Histidine kinase FOC13_13475 ENOG4105C2M dna polymerase I FOC13_13480 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC13_13490 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC13_13495 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC13_13505 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC13_13525 ENOG4108TDW sporulation protein YtxC FOC13_13530 ENOG4105C22 threonyL-tRNA synthetase FOC13_13535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC13_13555 ENOG4105CN9 Peptidase m42 family protein FOC13_13560 ENOG4108JGH Tetr family transcriptional regulator FOC13_13565 ENOG4105CW7 secretion protein, HlyD family FOC13_13570 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_13605 ENOG4108RWN rrna methyltransferase FOC13_13615 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC13_13620 ENOG4105C5S asparaginyl-tRNA synthetase FOC13_13655 ENOG4105DCG PHP domain protein FOC13_13665 ENOG4105FE9 pseudouridine synthase FOC13_13675 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC13_13685 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC13_13700 ENOG4105E0A ABC, transporter FOC13_13705 ENOG4105KFN sortase, SrtB family FOC13_13720 ENOG4105DR4 Methyltransferase FOC13_13730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_13770 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC13_13775 ENOG4105J76 Periplasmic binding protein FOC13_13785 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_13790 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_13795 ENOG41060WC Enoyl-CoA hydratase FOC13_13800 ENOG4105BZJ Electron transfer flavoprotein FOC13_13805 ENOG4105C10 Electron transfer flavoprotein FOC13_13810 ENOG4105K63 Thioredoxin FOC13_13825 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC13_13835 ENOG4105E33 succinate dehydrogenase FOC13_13845 ENOG4108VXD carboxy-peptidase FOC13_13850 ENOG4105E14 MotA TolQ exbB proton channel FOC13_13860 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC13_13865 ENOG4108IUX (ABC) transporter FOC13_13870 ENOG4105RHA ABC transporter, permease FOC13_13875 ENOG4108Z40 Transcriptional regulator FOC13_13880 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC13_13890 ENOG4108JCI Transcriptional regulator FOC13_13895 ENOG41067S9 phage shock protein C, PspC FOC13_13910 ENOG4105DY9 regulatoR FOC13_13920 ENOG4108JQ7 (ABC) transporter FOC13_13935 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC13_13940 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC13_13945 ENOG4105DZC cytosine deaminase FOC13_13950 ENOG4105DZC cytosine deaminase FOC13_13965 ENOG4105PFC Transcriptional regulator FOC13_13980 ENOG4105KBX Transcriptional regulator, TetR family FOC13_13990 ENOG4108PCX Major Facilitator FOC13_14000 ENOG4108XJQ germination protein FOC13_14010 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC13_14015 ENOG4105M59 Phosphodiesterase, mj0936 family FOC13_14035 ENOG4108QCI YvbH-like oligomerisation region FOC13_14060 ENOG4108IUQ atp-dependent protease FOC13_14080 ENOG4105K56 Transcriptional regulator FOC13_14105 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC13_14115 ENOG41068KH stage VI sporulation protein D FOC13_14125 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC13_14130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC13_14150 ENOG4105DFF Rod shape-determining protein mreb FOC13_14155 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC13_14170 ENOG4107QMS site-determining protein FOC13_14185 ENOG4105C03 ribonuclease FOC13_14195 ENOG4105X36 (ribosomal) protein FOC13_14210 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC13_14240 ENOG4105CQC Prephenate dehydratase FOC13_14245 ENOG4108RPX mosc domain containing protein FOC13_14260 ENOG4108IYU L-aspartate oxidase FOC13_14265 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC13_14290 ENOG41082BM Transcriptional regulator, arsr family FOC13_14295 ENOG4108IPJ Membrane FOC13_14300 ENOG4108IPJ Membrane FOC13_14310 ENOG4108HUF Transporter FOC13_14325 ENOG41061AI Protein of unknown function (DUF2905) FOC13_14340 ENOG4105VIE preprotein translocase, subunit YajC FOC13_14350 ENOG4108QG2 Membrane FOC13_14355 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC13_14365 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC13_14370 ENOG41076HS cation diffusion facilitator family transporter FOC13_14375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC13_14385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC13_14395 ENOG4105CUT histidyl-tRNA synthetase FOC13_14405 ENOG4105CUZ uba thif-type nad fad binding protein FOC13_14410 ENOG4108VCI transcription factor, rsfa family FOC13_14415 ENOG4105D1H recombination factor protein RarA FOC13_14425 ENOG4105C3J Cysteine desulfurase FOC13_14430 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC13_14440 ENOG4105C7H Helicase, RecD TraA family FOC13_14445 ENOG41060CR FOC13_14460 ENOG4105C02 permease FOC13_14470 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_14490 ENOG4105HHA aminodeoxychorismate lyase FOC13_14495 ENOG4108VQJ O-methyltransferase FOC13_14500 ENOG4105XYU peptidase (U32 family) FOC13_14505 ENOG4105CFP Peptidase U32 FOC13_14520 ENOG4107XRG penicillin-binding protein FOC13_14550 ENOG4105C28 cystathionine FOC13_14555 ENOG4108EKI Dehydrogenase FOC13_14565 ENOG4108V5C ABC transporter FOC13_14570 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC13_14620 ENOG4105MIR Phenylalanine 4-monooxygenase FOC13_14625 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC13_14660 ENOG4108MUZ hydrolase FOC13_14670 ENOG4105G6Z alkaline phosphatase FOC13_14685 ENOG4108TVJ Nitroreductase FOC13_14705 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_14720 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC13_14725 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC13_14735 ENOG410812S Rna-binding protein FOC13_14745 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC13_14755 ENOG4105DXX methyltransferase FOC13_14765 ENOG4105KQC Competence protein FOC13_14770 ENOG4108UK2 deaminase FOC13_14775 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC13_14785 ENOG4105TQK DNA polymerase iii, delta' subunit FOC13_14810 ENOG4105KVH Transcriptional regulator FOC13_14815 ENOG4105CSA Coproporphyrinogen iii oxidase FOC13_14825 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC13_14845 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC13_14850 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC13_14860 ENOG4105KTH gatB Yqey FOC13_14865 ENOG41068P3 sporulation protein YqfC FOC13_14875 ENOG4105C9A Phoh family FOC13_14880 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC13_14890 ENOG4107YR5 Diacylglycerol kinase FOC13_14895 ENOG4105KG3 cytidine deaminase FOC13_14900 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC13_14925 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC13_14930 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_14945 ENOG4105EGD dinuclear metal center protein, YbgI family FOC13_14970 ENOG41069ZM Protein of unknown function (DUF2624) FOC13_14975 ENOG4108JYZ YitT family FOC13_14980 ENOG4105FDK ABC transporter FOC13_14990 ENOG4105N80 Ferric uptake regulator, Fur family FOC13_15015 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC13_15025 ENOG4107RF6 penicillin-binding protein FOC13_15030 ENOG4105PWN phosphate abc transporter FOC13_15035 ENOG4105C8U phosphate abc transporter FOC13_15040 ENOG4105E2Z phosphate ABC transporter (Permease FOC13_15045 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC13_15050 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC13_15065 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC13_15075 ENOG4105DKQ ROK family FOC13_15085 ENOG4105C5X domain protein FOC13_15105 ENOG4105C28 cystathionine FOC13_15110 ENOG4105C28 cystathionine FOC13_15120 ENOG4105C3R Methionine synthase FOC13_15125 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC13_15245 ENOG4105C0D helicase FOC13_15275 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_15280 ENOG4105CJ1 ABC, transporter FOC13_15315 ENOG41080TC multidrug resistance protein FOC13_15335 ENOG4105WZW rhodanese family FOC13_15340 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC13_15360 ENOG4107YBY Hydrolase FOC13_15370 ENOG4105CBJ Metal-dependent enzyme FOC13_15385 ENOG4105DC7 peptidase M24 FOC13_15410 ENOG4105CD2 stage iii sporulation protein aa FOC13_15415 ENOG4105KR5 Stage iii sporulation protein FOC13_15420 ENOG4108CQH stage III sporulation protein AC FOC13_15425 ENOG4105KQ4 Stage iii sporulation protein ad FOC13_15435 ENOG410644B Stage III sporulation protein af FOC13_15460 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC13_15465 ENOG4108ZSR alkaline shock protein FOC13_15490 ENOG4105CTB Polyprenyl synthetase FOC13_15500 ENOG4105DX0 Hemolysin A FOC13_15510 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC13_15515 ENOG4105S1Z Stage IV sporulation protein B FOC13_15520 ENOG4107QQR Sporulation FOC13_15535 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC13_15545 ENOG4108JUB Transcriptional regulator FOC13_15555 ENOG4107RDP Dehydrogenase FOC13_15575 ENOG4105CPP Dehydrogenase, E1 component FOC13_15580 ENOG4105C7S Dehydrogenase FOC13_15595 ENOG4105G7B Protein of unknown function (DUF2992) FOC13_15605 ENOG4108HW3 (ABC) transporter FOC13_15610 ENOG4105E5Q amino acid AbC transporter FOC13_15615 ENOG4105CDA abc transporter atp-binding protein FOC13_15620 ENOG4108QEG Membrane FOC13_15625 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC13_15640 ENOG4105D9U N-acetyltransferase FOC13_15645 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC13_15655 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC13_15680 ENOG4105EJQ L-serine dehydratase FOC13_15685 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_15695 ENOG4108IXY short-chain dehydrogenase reductase FOC13_15710 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC13_15750 ENOG4105CGH 5'-nucleotidase FOC13_15755 ENOG4105DFD Na H antiporter FOC13_15765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_15775 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC13_15780 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_15785 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC13_15790 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC13_15810 ENOG4108R6K riboflavin synthase, subunit alpha FOC13_15815 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC13_15835 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC13_15840 ENOG4105ETE Transcriptional regulator (LacI family FOC13_15850 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC13_15870 ENOG4105RHY Pfam:UPF0157 FOC13_15880 ENOG4105CPC Aldo Keto reductase FOC13_15900 ENOG4105MZ9 stage II sporulation protein m FOC13_15905 ENOG4105I3K Ferric uptake regulator, Fur family FOC13_15915 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC13_15940 ENOG4105D7N magnesium and cobalt transport protein CorA FOC13_15970 ENOG4105DVE abc transporter atp-binding protein FOC13_15975 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_15980 ENOG4105DZ1 carboxypeptidase FOC13_15985 ENOG41082AN stage II sporulation protein FOC13_15995 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_16000 ENOG4105C8J )-transporter FOC13_16020 ENOG41090VF Stage v sporulation protein ac FOC13_16025 ENOG4105CZ3 stage V sporulation protein ad FOC13_16035 ENOG4105G6R Stage v sporulation protein ae FOC13_16045 ENOG4105J7I hydrolase FOC13_16050 ENOG4105PTM secreted protein FOC13_16055 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC13_16090 ENOG4105CE4 GlcNAc 6-P deacetylase FOC13_16100 ENOG4105FDP GntR family transcriptional regulator FOC13_16110 ENOG4105CID antiterminator FOC13_16125 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC13_16145 ENOG4106TD9 Diguanylate cyclase FOC13_16165 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC13_16190 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC13_16200 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC13_16210 ENOG4105DTD Dehydrogenase FOC13_16215 ENOG4105K7K Transcriptional regulator FOC13_16255 ENOG4105CHU acetyl-coa acetyltransferase FOC13_16300 ENOG4105CG3 alpha amylase, catalytic region FOC13_16310 ENOG4107FKK extracellular solute-binding protein family 1 FOC13_16320 ENOG4105EG2 ABC transporter, permease FOC13_16325 ENOG4105FKQ transcriptional regulator FOC13_16330 ENOG4105CHM Aminotransferase FOC13_16340 ENOG4108HGU Histidine kinase FOC13_16395 ENOG4105UIN FOC13_16405 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC13_16420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC13_16425 ENOG4105EPM Diguanylate phosphodiesterase FOC13_16440 ENOG4107IN1 Protein of unknown function (DUF1797) FOC13_16445 ENOG4108XRC Protein of unknown function (DUF458) FOC13_16480 ENOG4107ZYR domain protein FOC13_16485 ENOG4105CN5 Metallo-Beta-Lactamase FOC13_16500 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC13_16515 ENOG4105CPP Dehydrogenase, E1 component FOC13_16520 ENOG4105C7S Dehydrogenase FOC13_16565 ENOG4105CXN decarboxylase FOC13_16585 ENOG4105ECY inositol monophosphatase FOC13_16595 ENOG4105CI3 gtp-binding protein typa FOC13_16600 ENOG4105QA2 FOC13_16620 ENOG4108IAB Phoh family FOC13_16635 ENOG4105CNI cell division protein FtsW FOC13_16640 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC13_16690 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC13_16705 ENOG4107TB6 phosphoglycerate mutase FOC13_16725 ENOG4106H78 methyltransferase FOC13_16735 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC13_16740 ENOG4105D78 K07001 NTE family protein FOC13_16745 ENOG41063PX domain protein FOC13_16755 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC13_16775 ENOG4108IMY Transcriptional regulator FOC13_16820 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_16835 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC13_16920 ENOG4105CAR Terminase, large subunit FOC13_16930 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC13_17010 ENOG4105XSJ toxin secretion phage lysis holin FOC13_17060 ENOG4105KNH Nucleic acid-binding protein FOC13_17100 ENOG41068DC Essential cell division protein (By similarity) FOC13_17105 ENOG4105CJN penicillin-binding protein FOC13_17110 ENOG4105CJN penicillin-binding protein FOC13_17115 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC13_17130 ENOG4105CNI cell division protein FtsW FOC13_17135 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC13_17140 ENOG4105D4A Cell wall formation (By similarity) FOC13_17145 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC13_17150 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC13_17155 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC13_17165 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC13_17175 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC13_17180 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC13_17185 ENOG4105DFA alanine racemase domain protein FOC13_17195 ENOG41067XK integral membrane protein FOC13_17200 ENOG4105DBK s4 domain protein FOC13_17225 ENOG4105C34 Pseudouridine synthase FOC13_17250 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC13_17305 ENOG4105DC7 peptidase M24 FOC13_17310 ENOG4105F23 Fibronectin-binding protein FOC13_17320 ENOG4105DSJ YicC domain protein FOC13_17340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC13_17345 ENOG4105C25 Primosomal protein n' FOC13_17350 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC13_17360 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC13_17370 ENOG4108ZF3 Phosphatase FOC13_17375 ENOG4105D9P serine threonine protein kinase FOC13_17380 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC13_17385 ENOG4105DJV ribulose-phosphate 3-epimerase FOC13_17390 ENOG4105FJ0 thiamine FOC13_17405 ENOG4108ZAA Alkaline-shock protein FOC13_17410 ENOG4105DP4 dak2 domain fusion protein ylov FOC13_17415 ENOG4105CB5 ATP-dependent DNA helicase recG FOC13_17430 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC13_17435 ENOG4105CHR reductase FOC13_17450 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC13_17455 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC13_17475 ENOG4105VB6 UPF0109 protein FOC13_17500 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC13_17515 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC13_17525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC13_17535 ENOG4108HE4 integrase family FOC13_17575 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC13_17580 ENOG4105KNE Phosphatidate cytidylyltransferase FOC13_17585 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC13_17590 ENOG4105DZP Membrane-associated zinc metalloprotease FOC13_17600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC13_17610 ENOG4105CHV Transcription elongation factor NusA FOC13_17615 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC13_17620 ENOG4105VHM ribosomal protein FOC13_17630 ENOG4105W7A Protein of unknown function (DUF503) FOC13_17640 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC13_17645 ENOG4105DTN riboflavin biosynthesis protein ribF FOC13_17665 ENOG4105C1V Peptidase, M16 FOC13_17675 ENOG4105E35 Dipicolinate synthase subunit A FOC13_17680 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC13_17685 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC13_17695 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC13_17705 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC13_17715 ENOG4107QZI cell division protein FtsK FOC13_17720 ENOG4105FDP GntR family transcriptional regulator FOC13_17725 ENOG4105DIH basic membrane FOC13_17730 ENOG4108JQ9 ABC transporter FOC13_17755 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC13_17760 ENOG4105XZV Protein of unknown function (DUF3243) FOC13_17775 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC13_17800 ENOG4105D48 metallophosphoesterase FOC13_17805 ENOG4105MCT stage V sporulation protein S FOC13_17810 ENOG4108IGT Dipeptidase FOC13_17815 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC13_17820 ENOG4105DQU oxidoreductase, subunit beta FOC13_17825 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC13_17850 ENOG4105DA5 (ABC) transporter FOC13_17875 ENOG4107QHE Choloylglycine hydrolase FOC13_17885 ENOG410890F Dynamin family FOC13_17890 ENOG4105E0M Sulfatase FOC13_17895 ENOG4107R6R udp-galactopyranose mutase FOC13_17900 ENOG4105F0V Cell wall hydrolase FOC13_17925 ENOG4107YEI lmbE family FOC13_17930 ENOG4107TTQ Alpha beta hydrolase fold FOC13_17945 ENOG41067MG lrgb family FOC13_17965 ENOG4105BZU Histidine kinase FOC13_17970 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_18000 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC13_18005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC13_18015 ENOG4105CGK Exodeoxyribonuclease III FOC13_18035 ENOG4105E0A ABC, transporter FOC13_18040 ENOG4105NIV Esterase FOC13_18050 ENOG4105VPX protein, conserved in bacteria FOC13_18055 ENOG410681U heavy metal transport detoxification protein FOC13_18060 ENOG4105C59 p-type ATPase FOC13_18065 ENOG4105K70 DNA-binding protein FOC13_18070 ENOG4105TMB Formate nitrite transporter FOC13_18085 ENOG4105C85 amino acid FOC13_18095 ENOG4108SJC Membrane FOC13_18105 ENOG4105E98 transcriptional regulator DeoR family FOC13_18110 ENOG4105DE4 1-phosphofructokinase FOC13_18115 ENOG4105DM4 PTS System FOC13_18120 ENOG41069ER domain protein FOC13_18150 ENOG4106F1P AAA ATPase, central domain protein FOC13_18160 ENOG4105EN6 Membrane FOC13_18170 ENOG4105CXI aluminum resistance protein FOC13_18175 ENOG4105KV4 Transcriptional regulator FOC13_18180 ENOG4105C5F glutamine synthetase FOC13_18280 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC13_18465 ENOG4105XSJ toxin secretion phage lysis holin FOC13_18470 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC13_18500 ENOG4105K7K Transcriptional regulator FOC13_18520 ENOG4108SVB resolvase FOC13_18540 ENOG4105D5T phosphonate abc transporter FOC13_18555 ENOG4105D7V transposase FOC13_18575 ENOG4105BZ1 (ABC) transporter FOC13_18580 ENOG4105BZ1 (ABC) transporter FOC13_18595 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC13_18620 ENOG41067MG lrgb family FOC13_18625 ENOG4105VAW lrga family FOC13_18630 ENOG4107RSM transcriptional regulator FOC13_18640 ENOG4107QIV Cytochrome c biogenesis protein FOC13_18695 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC13_18720 ENOG4108903 Formimidoylglutamase FOC13_18725 ENOG4108VJ1 Transcriptional regulator (CarD family FOC13_18730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC13_18735 ENOG4105CBC glutamate synthase FOC13_18740 ENOG4105CK7 Sodium proline symporter FOC13_18745 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC13_18750 ENOG4105FBA Phospholipase Carboxylesterase FOC13_18755 ENOG4105BZU Histidine kinase FOC13_18765 ENOG4107AYK membrAne FOC13_18815 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_18820 ENOG4107ZYJ bioY protein FOC13_18825 ENOG4107F3J Amp-dependent synthetase and ligase FOC13_18845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC13_18885 ENOG4108I0Z Aconitate hydratase FOC13_18890 ENOG4108JJA ABC, transporter FOC13_18900 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC13_18905 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC13_18935 ENOG4105W8X HesB YadR YfhF-family protein FOC13_18940 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC13_18945 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC13_18955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_18960 ENOG4105C0H protease FOC13_18965 ENOG4105K4P CoA-binding domain protein FOC13_18970 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC13_18980 ENOG4105D9R oxidoreductase FOC13_18990 ENOG4105CIG ABC transporter FOC13_19005 ENOG4105EMN RNA polymerase sigma factor FOC13_19015 ENOG4108KGH TRANSCRIPTIONal FOC13_19080 ENOG4105E1K spore germination protein FOC13_19085 ENOG4108JB9 formate dehydrogenase FOC13_19095 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC13_19100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC13_19110 ENOG4105TMB Formate nitrite transporter FOC13_19115 ENOG4105D06 uba thif-type nad fad binding protein FOC13_19120 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_19125 ENOG4108ZAF Molybdopterin FOC13_19135 ENOG4105D1F ATP-binding protein FOC13_19150 ENOG410696E Membrane FOC13_19155 ENOG4105FR1 rard protein FOC13_19165 ENOG4105EWU Squalene--hopene cyclase FOC13_19175 ENOG4105CHR reductase FOC13_19180 ENOG4105C26 Dehydrogenase FOC13_19190 ENOG4108IA2 Sodium pantothenate symporter FOC13_19205 ENOG4106IQC argininosuccinate lyase FOC13_19215 ENOG410904N short-chain dehydrogenase reductase FOC13_19235 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC13_19255 ENOG4105VEQ Cold shock protein FOC13_19270 ENOG4108R1P FOC13_19280 ENOG41073R8 VanW family FOC13_19285 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_19300 ENOG4105KT7 mgtC SapB transporter FOC13_19310 ENOG4105E39 Enoyl-CoA hydratase FOC13_19315 ENOG4105K64 Glycosyl transferase, family 2 FOC13_19325 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC13_19345 ENOG4105CQB FAD linked oxidase domain protein FOC13_19350 ENOG4105C09 Bile acid FOC13_19360 ENOG4105RHY Pfam:UPF0157 FOC13_19385 ENOG4105CIS alcohol dehydrogenase FOC13_19390 ENOG41082BM Transcriptional regulator, arsr family FOC13_19415 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC13_19445 ENOG4108A04 Beta-lactamase FOC13_19450 ENOG4105DPN Oligoendopeptidase f FOC13_19460 ENOG4105E5K Alpha-amylase FOC13_19470 ENOG4105C98 muts2 protein FOC13_19490 ENOG4107V2S Transcriptional regulator FOC13_19500 ENOG4107CUJ Protein of unknown function (DUF2690) FOC13_19520 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC13_19525 ENOG4105NX3 Membrane FOC13_19530 ENOG4105DQ5 transport system permease protein FOC13_19535 ENOG4105EHG Permease protein FOC13_19540 ENOG4108MES Periplasmic binding protein FOC13_19560 ENOG4107R3E Citrate transporter FOC13_19570 ENOG4108TN2 lmbE family FOC13_19640 ENOG4105H3G oxidoreductase FOC13_19650 ENOG4105ED2 Beta-lactamase FOC13_19675 ENOG4107YXZ hydrolase, family 25 FOC13_19690 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC13_19715 ENOG4105KAF membrAne FOC13_19785 ENOG4105KVH Transcriptional regulator FOC13_19805 ENOG4105CHR reductase FOC13_19815 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC13_19850 ENOG4105KVH Transcriptional regulator FOC13_19855 ENOG4105KVH Transcriptional regulator FOC13_19860 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC13_19870 ENOG4108TZY GntR Family Transcriptional Regulator FOC13_19875 ENOG4105KVH Transcriptional regulator FOC13_19905 ENOG4105C44 Serine transporter FOC13_19910 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC13_19925 ENOG4105F27 Major Facilitator FOC13_19930 ENOG4105CV8 reductase FOC13_19950 ENOG4105D4Y metalloprotease FOC13_19955 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC13_19970 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC13_19975 ENOG4105CIS alcohol dehydrogenase FOC13_19980 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC13_19985 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC13_20000 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC13_20005 ENOG4105C6Z Gluconate FOC13_20010 ENOG4105CMG Carbohydrate kinase FOC13_20015 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC13_20020 ENOG4105XDF Protein of unknown function (DUF1272) FOC13_20025 ENOG4105DDN Pentapeptide repeat-containing protein FOC13_20040 ENOG4105C37 (CBS) domain FOC13_20070 ENOG4105EV4 Multidrug resistance protein mdtH FOC13_20080 ENOG4105DMQ Methyltransferase FOC13_20100 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC13_20105 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC13_20110 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC13_20120 ENOG4108UW5 maltose o-acetyltransferase FOC13_20125 ENOG4106UW1 Major Facilitator superfamily FOC13_20130 ENOG4105DKQ ROK family FOC13_20135 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_20195 ENOG4105CJ1 ABC, transporter FOC13_20205 ENOG4108PSK reductase FOC13_20225 ENOG4108RCM Nitroreductase FOC13_20230 ENOG4105KVH Transcriptional regulator FOC13_20245 ENOG4105CUT histidyl-tRNA synthetase FOC13_20250 ENOG4108Z66 YbaK ebsC protein FOC13_20260 ENOG41067QW Transcriptional regulator FOC13_20275 ENOG4108K8S endonuclease I FOC13_20300 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC13_20305 ENOG4108JJB ABC transporter FOC13_20335 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC13_20345 ENOG4105CRW Short chain fatty acid transporter FOC13_20355 ENOG4105KBX Transcriptional regulator, TetR family FOC13_20360 ENOG4105KPY Small multidrug resistance protein FOC13_20365 ENOG4105RXJ FOC13_20375 ENOG41069JR FOC13_20380 ENOG4105DA5 (ABC) transporter FOC13_20400 ENOG4105CZM Major Facilitator FOC13_20405 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC13_20415 ENOG4108ISG Major Facilitator FOC13_20465 ENOG410874W AraC family transcriptional regulator FOC13_20470 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC13_20485 ENOG4108AEY RNA polymerase sigma factor FOC13_20505 ENOG4108JQ1 Dehydrogenase FOC13_20520 ENOG4105DVH amino acid FOC13_20530 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC13_20545 ENOG4108JPW Aminotransferase FOC13_20560 ENOG4105EJQ L-serine dehydratase FOC13_20565 ENOG4105C44 Serine transporter FOC13_20580 ENOG4108JGH Tetr family transcriptional regulator FOC13_20585 ENOG4105EQ0 Major Facilitator superfamily FOC13_20605 ENOG4107QJQ Mate efflux family protein FOC13_20635 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC13_20665 ENOG4105TRI Hydrolase FOC13_20695 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC13_20705 ENOG4106P55 Transcriptional regulator FOC13_20715 ENOG4107QR9 Iron-sulfur cluster binding protein FOC13_20720 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC13_20725 ENOG4105DJB Major Facilitator Superfamily FOC13_20730 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC13_20745 ENOG4108U05 Transcriptional regulator FOC13_20760 ENOG4105BZU Histidine kinase FOC13_20775 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC13_20780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC13_20795 ENOG4105JQZ Methyltransferase FOC13_20800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_20810 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC13_20815 ENOG4108NNI Beta-lactamase domain-containing protein FOC13_20830 ENOG4105VZ8 Transcriptional regulator FOC13_20850 ENOG4105K6H D-cysteine desulfhydrase FOC13_20875 ENOG41062D9 Histidine kinase FOC13_20880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_20895 ENOG4105IIP Membrane FOC13_20905 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_20910 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC13_20985 ENOG4108YXU transcriptional regulator AsnC family FOC13_20990 ENOG4105CHR reductase FOC13_21000 ENOG4105F7F Chaperone FOC13_21015 ENOG41085FC arsR family transcriptional regulator FOC13_21020 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_21025 ENOG4105D6J arsenicaL-resistance protein FOC13_21055 ENOG4105DIK (ABC) transporter FOC13_21060 ENOG4105CC5 ABC transporter FOC13_21065 ENOG4105DSE periplasmic solute binding protein FOC13_21070 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC13_21075 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC13_21090 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC13_21095 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC13_21110 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC13_21115 ENOG4108606 TspO/MBR family FOC13_21150 ENOG41090MY MarR family Transcriptional regulator FOC13_21175 ENOG4105CHJ isochorismatase hydrolase FOC13_21185 ENOG4105CH6 catalase FOC13_21190 ENOG4105CGH 5'-nucleotidase FOC13_21225 ENOG4105CSV Glutaminase FOC13_21260 ENOG4105C6K Malic enzyme FOC13_21270 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_21280 ENOG4105CUB amino acid FOC13_21285 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC13_21295 ENOG4108IMY Transcriptional regulator FOC13_21300 ENOG4105HDK L-asparaginase FOC13_21305 ENOG4108IJ0 Aspartate ammonia-lyase FOC13_21320 ENOG4105E2A Dehydrogenase FOC13_21380 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC13_21410 ENOG4105DWD nucleoside recognition domain protein FOC13_21425 ENOG4105FDT acyl-CoA dehydrogenase FOC13_21435 ENOG4108ZHR arsR family transcriptional regulator FOC13_21440 ENOG4108ZRV stage ii sporulation protein p FOC13_21445 ENOG4106N3A copper homeostasis protein cutc FOC13_21455 ENOG4107258 Transcriptional regulator FOC13_21460 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC13_21495 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC13_21540 ENOG4105F1N DNA alkylation repair FOC13_21550 ENOG4108IQI permease FOC13_21555 ENOG4105KNA -acetyltransferase FOC13_21560 ENOG410635A Membrane FOC13_21640 ENOG4108XET gCN5-related N-acetyltransferase FOC13_21670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC13_21680 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC13_21715 ENOG4105FS7 Transcriptional regulator FOC13_21720 ENOG4108TVJ Nitroreductase FOC13_21730 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_21770 ENOG4105C8Y Acetylornithine aminotransferase FOC13_21780 ENOG4105CKK Glycosyl transferase, family 2 FOC13_21805 ENOG4105CKK Glycosyl transferase, family 2 FOC13_21830 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_21855 ENOG41068WN FOC13_21865 ENOG4108WCX response regulator FOC13_21875 ENOG41090T1 Membrane FOC13_21890 ENOG4105VMP Transcriptional regulator FOC13_21900 ENOG4105G6Z alkaline phosphatase FOC13_21905 ENOG4105ECK Fatty Acid Desaturase FOC13_21910 ENOG4105E0Y RtcB Protein FOC13_21920 ENOG4107258 Transcriptional regulator FOC13_21930 ENOG4105II7 pyrroline-5-carboxylate reductase FOC13_21935 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC13_21965 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC13_21985 ENOG41061GT Aldolase FOC13_22000 ENOG4105DKT Transcriptional regulator FOC13_22010 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC13_22020 ENOG4105D4B ABC, transporter FOC13_22045 ENOG4105EMN RNA polymerase sigma factor FOC13_22055 ENOG41069ER domain protein FOC13_22090 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC13_22095 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC13_22100 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC13_22120 ENOG41082JN Transcriptional regulator FOC13_22125 ENOG4105EYF MMPL domain protein FOC13_22130 ENOG4105EYF MMPL domain protein FOC13_22135 ENOG4105EYF MMPL domain protein FOC13_22145 ENOG4105C5H ABC transporter FOC13_22150 ENOG4105E0M Sulfatase FOC13_22155 ENOG4108ZCF integral membrane protein FOC13_22165 ENOG4107VMI polysaccharide deacetylase FOC13_22175 ENOG4107VC0 DNA alkylation repair enzyme FOC13_22225 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC13_22245 ENOG4105E09 nadh pyrophosphatase FOC13_22270 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC13_22275 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC13_22280 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC13_22290 ENOG4105C02 permease FOC13_22360 ENOG4105CHM Aminotransferase FOC13_22395 ENOG41089UC methyltransferase, type 11 FOC13_22410 ENOG4107BMA Transglycosylase associated protein FOC13_22430 ENOG4106K7D Major facilitator family transporter FOC13_22435 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC13_22475 ENOG4105EPR degv family FOC13_22490 ENOG4105DPN Oligoendopeptidase f FOC13_22530 ENOG4105BZU Histidine kinase FOC13_22535 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC13_22580 ENOG4105DTQ mandelate racemase muconate lactonizing FOC13_22595 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC13_22600 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC13_22615 ENOG4107T5V SNARE associated Golgi FOC13_22655 ENOG41080HI glycine oxidase FOC13_22660 ENOG4105CTU Proline racemase FOC13_22665 ENOG4105CTU Proline racemase FOC13_22670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC13_22675 ENOG4105C26 Dehydrogenase FOC13_22680 ENOG4105BZG amino acid carrier protein FOC13_22700 ENOG4108M1A Chitin-binding protein FOC13_22745 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC13_22765 ENOG4105EEM helicase FOC13_22815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC13_22850 ENOG4108M1A Chitin-binding protein FOC13_22855 ENOG41082BV acetyltransferase FOC13_22860 ENOG4105E66 phosphoriboisomerase A FOC13_22885 ENOG4108IJ7 Glycine betaine FOC13_22890 ENOG4107SQ8 Glycine betaine FOC13_22920 ENOG4105RHY Pfam:UPF0157 FOC13_22925 ENOG4105E1F short-chain dehydrogenase reductase FOC13_22935 ENOG4107RUY (E1 component), alpha subunit FOC13_22945 ENOG4107QKR Dehydrogenase FOC13_22965 ENOG41062ES Transcriptional regulator FOC13_22985 ENOG4105E98 transcriptional regulator DeoR family FOC13_23000 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC13_23030 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_23035 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC13_23040 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC13_23045 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC13_23065 ENOG4105MSI germination protein ypeb FOC13_23085 ENOG4108V3A UPF0421 protein FOC13_23120 ENOG4105FDR Membrane FOC13_23130 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC13_23155 ENOG4108IUM Glycogen debranching enzyme FOC13_23170 ENOG4105DY8 decarboxylase FOC13_23190 ENOG4105PAD Hydrolase FOC13_23215 ENOG4107VFR oxidoreductase FOC13_23255 ENOG4105PKS Excinuclease abc c subunit domain protein FOC13_23290 ENOG4105KWG Pfam:DUF1696 FOC13_23320 ENOG4108XI2 Domain of unknown function (DUF1963) FOC13_23355 ENOG4108Z4K mutator MutT protein FOC13_23360 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC13_23365 ENOG4105E09 nadh pyrophosphatase FOC13_23380 ENOG4105FCD Major Facilitator FOC13_23410 ENOG4107Y9U Membrane FOC13_23430 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC13_23445 ENOG4107Y80 Major Facilitator superfamily FOC13_23475 ENOG4108V4B ThiJ pfpI FOC13_23510 ENOG4105FQP Beta-lactamase FOC13_23520 ENOG4105CJN penicillin-binding protein FOC13_23525 ENOG4105CB2 alcohol dehydrogenase FOC13_23540 ENOG4108HGU Histidine kinase FOC13_23555 ENOG4108JJB ABC transporter FOC13_23575 ENOG4107RF6 penicillin-binding protein FOC13_23580 ENOG4105BZU Histidine kinase FOC13_23590 ENOG410667J hydrolase FOC13_23690 ENOG4105ETU transcriptional activator (TenA FOC13_23795 ENOG4105CPQ Dehydrogenase FOC13_23830 ENOG4105CUV Homoserine Kinase FOC13_23845 ENOG4107Y80 Major Facilitator superfamily FOC13_23855 ENOG4105FQP Beta-lactamase FOC13_23870 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_23870 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC13_23910 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC13_23920 ENOG4105T9C HD domain FOC13_23935 ENOG4105DZ1 carboxypeptidase FOC13_23950 ENOG4105DBI uridine monophosphokinase FOC13_23955 ENOG4105WCN acetyltransferase FOC13_23965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC13_23970 ENOG4107QX3 carboxylase FOC13_23975 ENOG4105E39 Enoyl-CoA hydratase FOC13_23980 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC13_23985 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC13_23990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC13_23995 ENOG4105C1G acyl-Coa dehydrogenase FOC13_24010 ENOG4107Z3H Transcriptional regulator, TetR family FOC13_24020 ENOG4105CJ1 ABC, transporter FOC13_24035 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC13_24040 ENOG4105CEP NADH dehydrogenase FOC13_24045 ENOG4106ANW SMI1_KNR4 FOC13_24060 ENOG4105BZU Histidine kinase FOC13_24070 ENOG4105C5H ABC transporter FOC13_24075 ENOG41067SE Tetr family transcriptional regulator FOC13_24095 ENOG4108VXD carboxy-peptidase FOC13_24110 ENOG4105VZ8 Transcriptional regulator FOC13_24140 ENOG4105DH8 myo-inositol catabolism FOC13_24145 ENOG4105D2N Aldolase FOC13_24170 ENOG4105CK5 oxidoreductase FOC13_24175 ENOG4105IE8 Alpha-ketoglutarate permease FOC13_24180 ENOG4105ETE Transcriptional regulator (LacI family FOC13_24185 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC13_24200 ENOG4107RF6 penicillin-binding protein FOC13_24225 ENOG4105CIN aminoacyl-histidine dipeptidase FOC13_24255 ENOG41090HR transcriptional regulator FOC13_24260 ENOG4107RA9 decarboxylase FOC13_24265 ENOG4108I0C methyltransferase FOC13_24275 ENOG41088CC tellurite resistance protein tehB FOC13_24295 ENOG4108RZE Tetr family transcriptional regulator FOC13_24310 ENOG4105C1J atp-dependent rna helicase FOC13_24325 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC13_24345 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC13_24355 ENOG4105RD7 BadF BadG BcrA BcrD FOC13_24405 ENOG4108KPJ rna polymerase sigma factor FOC13_24435 ENOG4108JCI Transcriptional regulator FOC13_24455 ENOG4105BZ1 (ABC) transporter FOC13_24460 ENOG4105BZ1 (ABC) transporter FOC13_24475 ENOG4108RPX mosc domain containing protein FOC13_24480 ENOG4105DND Transcriptional regulator FOC13_24495 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC13_24500 ENOG4107V2S Transcriptional regulator FOC13_24535 ENOG410667J hydrolase FOC13_24555 ENOG4105VEQ Cold shock protein FOC13_24565 ENOG41068WN FOC13_24575 ENOG4105C1Q protoporphyrinogen oxidase FOC13_24605 ENOG4105WCN acetyltransferase FOC13_24630 ENOG4105EYF MMPL domain protein FOC13_24640 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC13_24655 ENOG41081I9 integral membrane protein FOC13_24685 ENOG4108D32 Methyltransferase FOC13_24710 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC13_24725 ENOG4105C22 threonyL-tRNA synthetase FOC13_24730 ENOG4105FE9 pseudouridine synthase FOC13_24750 ENOG4105BZG amino acid carrier protein FOC13_24770 ENOG4105K70 DNA-binding protein FOC13_24785 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC13_24790 ENOG4105WQT MbtH domain protein FOC13_24795 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_24800 ENOG4105WQI isochorismatase FOC13_24805 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC13_24810 ENOG4105E4F Isochorismate synthase FOC13_24815 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC13_24820 ENOG4105FCD Major Facilitator FOC13_24840 ENOG4105EYH Exonuclease FOC13_24845 ENOG4107RFY SbcCD D subunit FOC13_24860 ENOG4105E39 Enoyl-CoA hydratase FOC13_24865 ENOG4105N14 lysine exporter protein LysE YggA FOC13_24875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC13_24880 ENOG4105C1G acyl-Coa dehydrogenase FOC13_24885 ENOG4105CR4 methylisocitrate lyase FOC13_24890 ENOG4105DXD 2-methylcitrate dehydratase FOC13_24900 ENOG4105W8X HesB YadR YfhF-family protein FOC13_24905 ENOG4105CZM Major Facilitator FOC13_24910 ENOG4105BZ4 penicillin-binding protein FOC13_24950 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC13_25055 ENOG4108IBT Inherit from COG: transposase FOC13_25070 ENOG4105SZ6 Thioredoxin FOC13_25080 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC13_25085 ENOG4108N23 SpoOM-related protein FOC13_25125 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC13_25130 ENOG4108JUB Transcriptional regulator FOC13_25135 ENOG4108TSC N-acetyltransferase FOC13_25140 ENOG4107S4Y M20 DapE family protein YgeY FOC13_25155 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC13_25180 ENOG4105C37 (CBS) domain FOC13_25215 ENOG4105E90 ABC transporter FOC13_25220 ENOG4108IJ8 ABC transporter FOC13_25245 ENOG4105CMG Carbohydrate kinase FOC13_25250 ENOG4105CMG Carbohydrate kinase FOC13_25285 ENOG4105WH1 Two component transcriptional regulator luxr family FOC13_25290 ENOG4105BZU Histidine kinase FOC13_25295 ENOG4105D8X mechanosensitive ion channel FOC13_25330 ENOG4105F0I Aminotransferase FOC13_25335 ENOG4108MES Periplasmic binding protein FOC13_25350 ENOG4105CAQ asparagine synthetase FOC13_25355 ENOG4107Y70 Heat shock protein FOC13_25360 ENOG4108KF3 Electron transport protein SCO1 SenC FOC13_25365 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC13_25370 ENOG4108RCR degv family FOC13_25380 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC13_25390 ENOG4108UT2 hemolysin iii FOC13_25400 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC13_25405 ENOG4107RVG penicillin-binding protein FOC13_25420 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC13_25440 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC13_25470 ENOG4105KD7 acetyltransferase FOC13_25485 ENOG4105C0A alcohol dehydrogenase FOC13_25490 ENOG4105CY2 Citrate transporter FOC13_25495 ENOG4107XGZ Hydrolase FOC13_25515 ENOG4105C8J )-transporter FOC13_25530 ENOG41062D9 Histidine kinase FOC13_25535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC13_25540 ENOG4107QPK )-transporter FOC13_25545 ENOG4105BZW Glycerate kinase FOC13_25615 ENOG4105EC2 ftsk spoIIIe FOC13_25635 ENOG4105C5S asparaginyl-tRNA synthetase FOC13_25655 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC13_25680 ENOG4105C75 arginyL-tRNA synthetase FOC13_25685 ENOG4107YX5 Pfam:DUF548 FOC13_25715 ENOG4108UUM single-stranded DNA-binding protein FOC13_25730 ENOG4105C5H ABC transporter FOC13_25750 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC13_25765 ENOG4105MCT stage V sporulation protein S FOC13_25800 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC13_25805 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC13_25810 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC13_25815 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC13_25820 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC13_25825 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC13_25850 ENOG4108ZAF Molybdopterin FOC13_25855 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC13_25860 ENOG4105D06 uba thif-type nad fad binding protein FOC13_25865 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC13_25870 ENOG4107V6Q Cyclic nucleotide-binding domain FOC13_25895 ENOG4105R3A Nitrate reductase FOC13_25900 ENOG4108IUE nitrate reductase beta subunit FOC13_25920 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC13_25935 ENOG4108V06 Glutathione peroxidase FOC13_25960 ENOG4105EMN RNA polymerase sigma factor FOC13_25965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC13_25975 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC13_26000 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC13_26025 ENOG4105KBJ sporulation protein ytfj FOC13_26075 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC13_26100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC13_26105 ENOG4108JYZ YitT family FOC13_26110 ENOG41087PP glycosyltransferase MGT family FOC13_26125 ENOG4107RBS Methyltransferase FOC13_26130 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC13_26140 ENOG4108X4Q Hydrolase FOC13_26165 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC13_26175 ENOG4108VXD carboxy-peptidase FOC13_26185 ENOG4108ZRV stage ii sporulation protein p FOC13_26205 ENOG4108Z7R Chaperone CsaA FOC13_26225 ENOG4105C37 (CBS) domain FOC13_26230 ENOG4105SXS Protein of unknown function (DUF456) FOC13_26250 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC13_26260 ENOG4108S4H thioesterase Superfamily protein FOC13_26270 ENOG4108PJD permease FOC13_26285 ENOG4107T5V SNARE associated Golgi FOC13_26305 ENOG4105CVJ phosphoglycerate mutase FOC13_26330 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC13_26340 ENOG4105K4T epimerase FOC13_26345 ENOG4105DSE periplasmic solute binding protein FOC13_26400 ENOG4105CKI cobalamin synthesis protein FOC13_26405 ENOG4107QM2 Aldo Keto reductase FOC13_26425 ENOG4105DEN Luciferase family FOC13_26440 ENOG4108WPJ Ferritin-like domain FOC13_26445 ENOG4108K88 Membrane FOC13_26460 ENOG4105C8Q Methyl-accepting chemotaxis FOC13_26485 ENOG4107XZQ multidrug resistance protein FOC13_26490 ENOG4107SET aldo keto reductase FOC13_26495 ENOG4105YVS arsR family transcriptional regulator FOC13_26505 ENOG4105KRN Transcriptional regulator, abrb family FOC13_26555 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC13_26565 ENOG4105YWU small acid-soluble spore protein FOC13_26570 ENOG4108WBH protein TIM barrel FOC13_26585 ENOG4105CEY Amp-dependent synthetase and ligase FOC13_26590 ENOG4105DUU IucA IucC family protein FOC13_26600 ENOG4105VRR gCN5-related N-acetyltransferase FOC13_26605 ENOG4105KT7 mgtC SapB transporter FOC13_26615 ENOG4107VMI polysaccharide deacetylase FOC13_26620 ENOG4105BZU Histidine kinase FOC13_26625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC13_26635 ENOG4108KGH TRANSCRIPTIONal FOC13_26660 ENOG4105D6E homoserine dehydrogenase FOC13_26680 ENOG4108ZJ4 polysaccharide deacetylase FOC13_26685 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC13_26705 ENOG4105BZU Histidine kinase FOC13_26710 ENOG4105EFI regulatoR FOC13_26760 ENOG4108JJ8 (ABC) transporter FOC13_26765 ENOG4108JJ9 ABC, transporter FOC13_26770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC13_26775 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC13_26785 ENOG4105YGB Transcriptional regulator FOC13_26805 ENOG4105SKE transcriptional Regulator LysR family FOC13_26815 ENOG4105C32 Amino acid ABC transporter (Permease) FOC13_26820 ENOG4108IV0 ABC, transporter FOC13_26825 ENOG4105C0Z ABC transporter FOC13_26835 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC13_26840 ENOG4108Z7G MaoC domain protein dehydratase FOC13_26860 ENOG4105CKI cobalamin synthesis protein FOC13_26870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC13_26875 ENOG4106F5Q Membrane FOC13_26880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC13_26885 ENOG4108TVJ Nitroreductase FOC13_26890 ENOG4107ZXU DSBA oxidoreductase FOC13_26895 ENOG4108Z40 Transcriptional regulator FOC13_26900 ENOG4105GZI Transcriptional regulator FOC13_26905 ENOG4107RT3 EamA-like transporter family FOC13_26915 ENOG4105KTB nuclear export factor GLE1 FOC13_26920 ENOG4108T5E Copper resistance protein FOC13_26965 ENOG4107STQ Multicopper oxidase FOC13_26970 ENOG4107RAQ aminopeptidase FOC13_27005 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC13_27010 ENOG4105D9N nucleoside FOC13_27020 ENOG4107RHR regulatoR FOC13_27050 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC13_27060 ENOG4105C72 UPF0176 protein FOC13_27065 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC13_27100 ENOG4108QY5 Ferric enterobactin transport protein