locus-tag class description FOC14_00015 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC14_00025 ENOG4105EYF MMPL domain protein FOC14_00050 ENOG4105WCN acetyltransferase FOC14_00080 ENOG4105C1Q protoporphyrinogen oxidase FOC14_00090 ENOG41068WN FOC14_00100 ENOG4105VEQ Cold shock protein FOC14_00120 ENOG410667J hydrolase FOC14_00160 ENOG4107V2S Transcriptional regulator FOC14_00165 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC14_00180 ENOG4105DND Transcriptional regulator FOC14_00185 ENOG4108RPX mosc domain containing protein FOC14_00200 ENOG4105BZ1 (ABC) transporter FOC14_00205 ENOG4105BZ1 (ABC) transporter FOC14_00225 ENOG4108JCI Transcriptional regulator FOC14_00255 ENOG4108KPJ rna polymerase sigma factor FOC14_00305 ENOG4105RD7 BadF BadG BcrA BcrD FOC14_00315 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC14_00335 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC14_00350 ENOG4105C1J atp-dependent rna helicase FOC14_00365 ENOG4108RZE Tetr family transcriptional regulator FOC14_00385 ENOG41088CC tellurite resistance protein tehB FOC14_00395 ENOG4108I0C methyltransferase FOC14_00400 ENOG4107RA9 decarboxylase FOC14_00405 ENOG41090HR transcriptional regulator FOC14_00435 ENOG4105CIN aminoacyl-histidine dipeptidase FOC14_00460 ENOG4107RF6 penicillin-binding protein FOC14_00475 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC14_00480 ENOG4105ETE Transcriptional regulator (LacI family FOC14_00485 ENOG4105IE8 Alpha-ketoglutarate permease FOC14_00490 ENOG4105CK5 oxidoreductase FOC14_00515 ENOG4105D2N Aldolase FOC14_00520 ENOG4105DH8 myo-inositol catabolism FOC14_00550 ENOG4105VZ8 Transcriptional regulator FOC14_00565 ENOG4108VXD carboxy-peptidase FOC14_00585 ENOG41067SE Tetr family transcriptional regulator FOC14_00590 ENOG4105C5H ABC transporter FOC14_00600 ENOG4105BZU Histidine kinase FOC14_00615 ENOG4106ANW SMI1_KNR4 FOC14_00620 ENOG4105CEP NADH dehydrogenase FOC14_00625 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC14_00640 ENOG4105CJ1 ABC, transporter FOC14_00650 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_00665 ENOG4105C1G acyl-Coa dehydrogenase FOC14_00670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC14_00675 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC14_00680 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC14_00685 ENOG4105E39 Enoyl-CoA hydratase FOC14_00690 ENOG4107QX3 carboxylase FOC14_00695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC14_00705 ENOG4105WCN acetyltransferase FOC14_00710 ENOG4105DBI uridine monophosphokinase FOC14_00725 ENOG4105DZ1 carboxypeptidase FOC14_00740 ENOG4105T9C HD domain FOC14_00750 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC14_00790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_00790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_00805 ENOG4105FQP Beta-lactamase FOC14_00815 ENOG4107Y80 Major Facilitator superfamily FOC14_00835 ENOG4105CUV Homoserine Kinase FOC14_00870 ENOG4105CPQ Dehydrogenase FOC14_00975 ENOG4105ETU transcriptional activator (TenA FOC14_01075 ENOG410667J hydrolase FOC14_01085 ENOG4105BZU Histidine kinase FOC14_01090 ENOG4107RF6 penicillin-binding protein FOC14_01110 ENOG4108JJB ABC transporter FOC14_01125 ENOG4108HGU Histidine kinase FOC14_01140 ENOG4105CB2 alcohol dehydrogenase FOC14_01145 ENOG4105CJN penicillin-binding protein FOC14_01155 ENOG4105FQP Beta-lactamase FOC14_01190 ENOG4108V4B ThiJ pfpI FOC14_01220 ENOG4107Y80 Major Facilitator superfamily FOC14_01235 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC14_01255 ENOG4107Y9U Membrane FOC14_01285 ENOG4105FCD Major Facilitator FOC14_01300 ENOG4105E09 nadh pyrophosphatase FOC14_01305 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC14_01310 ENOG4108Z4K mutator MutT protein FOC14_01345 ENOG4108XI2 Domain of unknown function (DUF1963) FOC14_01375 ENOG4105KWG Pfam:DUF1696 FOC14_01410 ENOG4105PKS Excinuclease abc c subunit domain protein FOC14_01450 ENOG4107VFR oxidoreductase FOC14_01475 ENOG4105PAD Hydrolase FOC14_01495 ENOG4105DY8 decarboxylase FOC14_01510 ENOG4108IUM Glycogen debranching enzyme FOC14_01535 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC14_01545 ENOG4105FDR Membrane FOC14_01580 ENOG4108V3A UPF0421 protein FOC14_01600 ENOG4105MSI germination protein ypeb FOC14_01620 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC14_01625 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC14_01630 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC14_01635 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_01665 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC14_01680 ENOG4105E98 transcriptional regulator DeoR family FOC14_01700 ENOG41062ES Transcriptional regulator FOC14_01720 ENOG4107QKR Dehydrogenase FOC14_01730 ENOG4107RUY (E1 component), alpha subunit FOC14_01740 ENOG4105E1F short-chain dehydrogenase reductase FOC14_01745 ENOG4105RHY Pfam:UPF0157 FOC14_01775 ENOG4107SQ8 Glycine betaine FOC14_01780 ENOG4108IJ7 Glycine betaine FOC14_01805 ENOG4105E66 phosphoriboisomerase A FOC14_01810 ENOG41082BV acetyltransferase FOC14_01815 ENOG4108M1A Chitin-binding protein FOC14_01850 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC14_01900 ENOG4105EEM helicase FOC14_01920 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC14_01965 ENOG4108M1A Chitin-binding protein FOC14_01985 ENOG4105BZG amino acid carrier protein FOC14_01990 ENOG4105C26 Dehydrogenase FOC14_01995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC14_02000 ENOG4105CTU Proline racemase FOC14_02005 ENOG4105CTU Proline racemase FOC14_02010 ENOG41080HI glycine oxidase FOC14_02050 ENOG4107T5V SNARE associated Golgi FOC14_02065 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC14_02070 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC14_02085 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_02130 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC14_02135 ENOG4105BZU Histidine kinase FOC14_02175 ENOG4105DPN Oligoendopeptidase f FOC14_02190 ENOG4105EPR degv family FOC14_02230 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC14_02235 ENOG4106K7D Major facilitator family transporter FOC14_02255 ENOG4107BMA Transglycosylase associated protein FOC14_02270 ENOG41089UC methyltransferase, type 11 FOC14_02305 ENOG4105CHM Aminotransferase FOC14_02375 ENOG4105C02 permease FOC14_02385 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC14_02390 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC14_02395 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC14_02420 ENOG4105E09 nadh pyrophosphatase FOC14_02440 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC14_02490 ENOG4107VC0 DNA alkylation repair enzyme FOC14_02500 ENOG4107VMI polysaccharide deacetylase FOC14_02510 ENOG4108ZCF integral membrane protein FOC14_02515 ENOG4105E0M Sulfatase FOC14_02520 ENOG4105C5H ABC transporter FOC14_02530 ENOG4105EYF MMPL domain protein FOC14_02535 ENOG4105EYF MMPL domain protein FOC14_02540 ENOG4105EYF MMPL domain protein FOC14_02545 ENOG41082JN Transcriptional regulator FOC14_02565 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC14_02570 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC14_02575 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC14_02610 ENOG41069ER domain protein FOC14_02620 ENOG4105EMN RNA polymerase sigma factor FOC14_02645 ENOG4105D4B ABC, transporter FOC14_02655 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC14_02665 ENOG4105DKT Transcriptional regulator FOC14_02680 ENOG41061GT Aldolase FOC14_02700 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC14_02730 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC14_02735 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_02745 ENOG4107258 Transcriptional regulator FOC14_02755 ENOG4105E0Y RtcB Protein FOC14_02760 ENOG4105ECK Fatty Acid Desaturase FOC14_02765 ENOG4105G6Z alkaline phosphatase FOC14_02775 ENOG4105VMP Transcriptional regulator FOC14_02790 ENOG41090T1 Membrane FOC14_02800 ENOG4108WCX response regulator FOC14_02810 ENOG41068WN FOC14_02835 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_02860 ENOG4105CKK Glycosyl transferase, family 2 FOC14_02885 ENOG4105CKK Glycosyl transferase, family 2 FOC14_02895 ENOG4105C8Y Acetylornithine aminotransferase FOC14_02935 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_02945 ENOG4108TVJ Nitroreductase FOC14_02950 ENOG4105FS7 Transcriptional regulator FOC14_02985 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_02995 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC14_03025 ENOG4108XET gCN5-related N-acetyltransferase FOC14_03105 ENOG410635A Membrane FOC14_03110 ENOG4105KNA -acetyltransferase FOC14_03115 ENOG4108IQI permease FOC14_03125 ENOG4105F1N DNA alkylation repair FOC14_03175 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC14_03210 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC14_03215 ENOG4107258 Transcriptional regulator FOC14_03225 ENOG4106N3A copper homeostasis protein cutc FOC14_03230 ENOG4108ZRV stage ii sporulation protein p FOC14_03235 ENOG4108ZHR arsR family transcriptional regulator FOC14_03245 ENOG4105FDT acyl-CoA dehydrogenase FOC14_03260 ENOG4105DWD nucleoside recognition domain protein FOC14_03290 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC14_03350 ENOG4105E2A Dehydrogenase FOC14_03365 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_03370 ENOG4105HDK L-asparaginase FOC14_03375 ENOG4108IMY Transcriptional regulator FOC14_03385 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC14_03390 ENOG4105CUB amino acid FOC14_03400 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_03410 ENOG4105C6K Malic enzyme FOC14_03445 ENOG4105CSV Glutaminase FOC14_03480 ENOG4105CGH 5'-nucleotidase FOC14_03485 ENOG4105CH6 catalase FOC14_03495 ENOG4105CHJ isochorismatase hydrolase FOC14_03520 ENOG41090MY MarR family Transcriptional regulator FOC14_03555 ENOG4108606 TspO/MBR family FOC14_03560 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC14_03575 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC14_03580 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC14_03595 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC14_03600 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC14_03605 ENOG4105DSE periplasmic solute binding protein FOC14_03610 ENOG4105CC5 ABC transporter FOC14_03615 ENOG4105DIK (ABC) transporter FOC14_03645 ENOG4105D6J arsenicaL-resistance protein FOC14_03650 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_03655 ENOG41085FC arsR family transcriptional regulator FOC14_03670 ENOG4105F7F Chaperone FOC14_03680 ENOG4105CHR reductase FOC14_03685 ENOG4108YXU transcriptional regulator AsnC family FOC14_03760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC14_03765 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_03775 ENOG4105IIP Membrane FOC14_03790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_03795 ENOG41062D9 Histidine kinase FOC14_03820 ENOG4105K6H D-cysteine desulfhydrase FOC14_03840 ENOG4105VZ8 Transcriptional regulator FOC14_03855 ENOG4108NNI Beta-lactamase domain-containing protein FOC14_03860 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC14_03870 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_03875 ENOG4105JQZ Methyltransferase FOC14_03890 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC14_03895 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC14_03910 ENOG4105BZU Histidine kinase FOC14_03925 ENOG4108U05 Transcriptional regulator FOC14_03940 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC14_03945 ENOG4105DJB Major Facilitator Superfamily FOC14_03950 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC14_03955 ENOG4107QR9 Iron-sulfur cluster binding protein FOC14_03965 ENOG4106P55 Transcriptional regulator FOC14_03975 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC14_04010 ENOG4105TRI Hydrolase FOC14_04040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC14_04070 ENOG4107QJQ Mate efflux family protein FOC14_04090 ENOG4105EQ0 Major Facilitator superfamily FOC14_04095 ENOG4108JGH Tetr family transcriptional regulator FOC14_04110 ENOG4105C44 Serine transporter FOC14_04115 ENOG4105EJQ L-serine dehydratase FOC14_04130 ENOG4108JPW Aminotransferase FOC14_04145 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC14_04155 ENOG4105DVH amino acid FOC14_04170 ENOG4108JQ1 Dehydrogenase FOC14_04190 ENOG4108AEY RNA polymerase sigma factor FOC14_04205 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC14_04210 ENOG410874W AraC family transcriptional regulator FOC14_04260 ENOG4108ISG Major Facilitator FOC14_04270 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC14_04275 ENOG4105CZM Major Facilitator FOC14_04295 ENOG4105DA5 (ABC) transporter FOC14_04300 ENOG41069JR FOC14_04310 ENOG4105RXJ FOC14_04315 ENOG4105KPY Small multidrug resistance protein FOC14_04320 ENOG4105KBX Transcriptional regulator, TetR family FOC14_04330 ENOG4105CRW Short chain fatty acid transporter FOC14_04340 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC14_04370 ENOG4108JJB ABC transporter FOC14_04375 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC14_04400 ENOG4108K8S endonuclease I FOC14_04415 ENOG41067QW Transcriptional regulator FOC14_04425 ENOG4108Z66 YbaK ebsC protein FOC14_04430 ENOG4105CUT histidyl-tRNA synthetase FOC14_04445 ENOG4105KVH Transcriptional regulator FOC14_04450 ENOG4108RCM Nitroreductase FOC14_04470 ENOG4108PSK reductase FOC14_04480 ENOG4105CJ1 ABC, transporter FOC14_04540 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_04545 ENOG4105DKQ ROK family FOC14_04550 ENOG4106UW1 Major Facilitator superfamily FOC14_04555 ENOG4108UW5 maltose o-acetyltransferase FOC14_04565 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC14_04570 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC14_04575 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC14_04595 ENOG4105DMQ Methyltransferase FOC14_04605 ENOG4105EV4 Multidrug resistance protein mdtH FOC14_04635 ENOG4105C37 (CBS) domain FOC14_04650 ENOG4105DDN Pentapeptide repeat-containing protein FOC14_04655 ENOG4105XDF Protein of unknown function (DUF1272) FOC14_04660 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC14_04665 ENOG4105CMG Carbohydrate kinase FOC14_04670 ENOG4105C6Z Gluconate FOC14_04675 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC14_04690 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC14_04695 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC14_04700 ENOG4105CIS alcohol dehydrogenase FOC14_04705 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC14_04720 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC14_04725 ENOG4105D4Y metalloprotease FOC14_04745 ENOG4105CV8 reductase FOC14_04750 ENOG4105F27 Major Facilitator FOC14_04765 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC14_04770 ENOG4105C44 Serine transporter FOC14_04800 ENOG4105KVH Transcriptional regulator FOC14_04805 ENOG4108TZY GntR Family Transcriptional Regulator FOC14_04815 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC14_04820 ENOG4105KVH Transcriptional regulator FOC14_04825 ENOG4105KVH Transcriptional regulator FOC14_04860 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC14_04870 ENOG4105CHR reductase FOC14_04890 ENOG4105KVH Transcriptional regulator FOC14_04960 ENOG4105KAF membrAne FOC14_04985 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC14_05000 ENOG4107YXZ hydrolase, family 25 FOC14_05025 ENOG4105ED2 Beta-lactamase FOC14_05035 ENOG4105H3G oxidoreductase FOC14_05105 ENOG4108TN2 lmbE family FOC14_05115 ENOG4107R3E Citrate transporter FOC14_05135 ENOG4108MES Periplasmic binding protein FOC14_05140 ENOG4105EHG Permease protein FOC14_05145 ENOG4105DQ5 transport system permease protein FOC14_05150 ENOG4105NX3 Membrane FOC14_05155 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC14_05175 ENOG4107CUJ Protein of unknown function (DUF2690) FOC14_05185 ENOG4107V2S Transcriptional regulator FOC14_05205 ENOG4105C98 muts2 protein FOC14_05215 ENOG4105E5K Alpha-amylase FOC14_05225 ENOG4105DPN Oligoendopeptidase f FOC14_05230 ENOG4108A04 Beta-lactamase FOC14_05260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC14_05285 ENOG41082BM Transcriptional regulator, arsr family FOC14_05290 ENOG4105CIS alcohol dehydrogenase FOC14_05315 ENOG4105RHY Pfam:UPF0157 FOC14_05325 ENOG4105C09 Bile acid FOC14_05330 ENOG4105CQB FAD linked oxidase domain protein FOC14_05350 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC14_05360 ENOG4105K64 Glycosyl transferase, family 2 FOC14_05365 ENOG4105E39 Enoyl-CoA hydratase FOC14_05375 ENOG4105KT7 mgtC SapB transporter FOC14_05390 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_05395 ENOG41073R8 VanW family FOC14_05405 ENOG4108R1P FOC14_05425 ENOG4105VEQ Cold shock protein FOC14_05445 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC14_05465 ENOG410904N short-chain dehydrogenase reductase FOC14_05475 ENOG4106IQC argininosuccinate lyase FOC14_05490 ENOG4108IA2 Sodium pantothenate symporter FOC14_05500 ENOG4105C26 Dehydrogenase FOC14_05505 ENOG4105CHR reductase FOC14_05515 ENOG4105EWU Squalene--hopene cyclase FOC14_05525 ENOG4105FR1 rard protein FOC14_05530 ENOG410696E Membrane FOC14_05545 ENOG4105D1F ATP-binding protein FOC14_05555 ENOG4108ZAF Molybdopterin FOC14_05560 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_05565 ENOG4105D06 uba thif-type nad fad binding protein FOC14_05570 ENOG4105TMB Formate nitrite transporter FOC14_05580 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC14_05585 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC14_05595 ENOG4108JB9 formate dehydrogenase FOC14_05600 ENOG4105E1K spore germination protein FOC14_05665 ENOG4108KGH TRANSCRIPTIONal FOC14_05675 ENOG4105EMN RNA polymerase sigma factor FOC14_05690 ENOG4105CIG ABC transporter FOC14_05700 ENOG4105D9R oxidoreductase FOC14_05710 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC14_05715 ENOG4105K4P CoA-binding domain protein FOC14_05720 ENOG4105C0H protease FOC14_05725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_05735 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC14_05740 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC14_05745 ENOG4105W8X HesB YadR YfhF-family protein FOC14_05775 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC14_05780 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC14_05790 ENOG4108JJA ABC, transporter FOC14_05795 ENOG4108I0Z Aconitate hydratase FOC14_05835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_05855 ENOG4107F3J Amp-dependent synthetase and ligase FOC14_05860 ENOG4107ZYJ bioY protein FOC14_05865 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_05915 ENOG4107AYK membrAne FOC14_05925 ENOG4105BZU Histidine kinase FOC14_05930 ENOG4105FBA Phospholipase Carboxylesterase FOC14_05935 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC14_05940 ENOG4105CK7 Sodium proline symporter FOC14_05945 ENOG4105CBC glutamate synthase FOC14_05950 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC14_05955 ENOG4108VJ1 Transcriptional regulator (CarD family FOC14_05960 ENOG4108903 Formimidoylglutamase FOC14_05985 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC14_06045 ENOG4107QIV Cytochrome c biogenesis protein FOC14_06055 ENOG4107RSM transcriptional regulator FOC14_06060 ENOG4105VAW lrga family FOC14_06065 ENOG41067MG lrgb family FOC14_06090 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC14_06105 ENOG4105BZ1 (ABC) transporter FOC14_06110 ENOG4105BZ1 (ABC) transporter FOC14_06130 ENOG4105D7V transposase FOC14_06145 ENOG4105D5T phosphonate abc transporter FOC14_06165 ENOG4108SVB resolvase FOC14_06185 ENOG4105K7K Transcriptional regulator FOC14_06215 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC14_06220 ENOG4105XSJ toxin secretion phage lysis holin FOC14_06405 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC14_06505 ENOG4105C5F glutamine synthetase FOC14_06510 ENOG4105KV4 Transcriptional regulator FOC14_06515 ENOG4105CXI aluminum resistance protein FOC14_06525 ENOG4105EN6 Membrane FOC14_06535 ENOG4106F1P AAA ATPase, central domain protein FOC14_06565 ENOG41069ER domain protein FOC14_06570 ENOG4105DM4 PTS System FOC14_06575 ENOG4105DE4 1-phosphofructokinase FOC14_06580 ENOG4105E98 transcriptional regulator DeoR family FOC14_06590 ENOG4108SJC Membrane FOC14_06600 ENOG4105C85 amino acid FOC14_06615 ENOG4105TMB Formate nitrite transporter FOC14_06620 ENOG4105K70 DNA-binding protein FOC14_06625 ENOG4105C59 p-type ATPase FOC14_06630 ENOG410681U heavy metal transport detoxification protein FOC14_06635 ENOG4105VPX protein, conserved in bacteria FOC14_06645 ENOG4105NIV Esterase FOC14_06650 ENOG4105E0A ABC, transporter FOC14_06670 ENOG4105CGK Exodeoxyribonuclease III FOC14_06680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC14_06685 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC14_06715 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_06720 ENOG4105BZU Histidine kinase FOC14_06740 ENOG41067MG lrgb family FOC14_06755 ENOG4107TTQ Alpha beta hydrolase fold FOC14_06760 ENOG4107YEI lmbE family FOC14_06785 ENOG4105F0V Cell wall hydrolase FOC14_06790 ENOG4107R6R udp-galactopyranose mutase FOC14_06795 ENOG4105E0M Sulfatase FOC14_06800 ENOG410890F Dynamin family FOC14_06810 ENOG4107QHE Choloylglycine hydrolase FOC14_06835 ENOG4105DA5 (ABC) transporter FOC14_06860 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC14_06865 ENOG4105DQU oxidoreductase, subunit beta FOC14_06870 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC14_06875 ENOG4108IGT Dipeptidase FOC14_06880 ENOG4105MCT stage V sporulation protein S FOC14_06885 ENOG4105D48 metallophosphoesterase FOC14_06910 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC14_06925 ENOG4105XZV Protein of unknown function (DUF3243) FOC14_06930 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC14_06955 ENOG4108JQ9 ABC transporter FOC14_06960 ENOG4105DIH basic membrane FOC14_06965 ENOG4105FDP GntR family transcriptional regulator FOC14_06970 ENOG4107QZI cell division protein FtsK FOC14_06980 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC14_06990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC14_07000 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC14_07005 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC14_07010 ENOG4105E35 Dipicolinate synthase subunit A FOC14_07020 ENOG4105C1V Peptidase, M16 FOC14_07040 ENOG4105DTN riboflavin biosynthesis protein ribF FOC14_07045 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC14_07055 ENOG4105W7A Protein of unknown function (DUF503) FOC14_07065 ENOG4105VHM ribosomal protein FOC14_07070 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC14_07075 ENOG4105CHV Transcription elongation factor NusA FOC14_07085 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC14_07095 ENOG4105DZP Membrane-associated zinc metalloprotease FOC14_07100 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC14_07105 ENOG4105KNE Phosphatidate cytidylyltransferase FOC14_07110 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC14_07150 ENOG4108HE4 integrase family FOC14_07160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC14_07170 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC14_07185 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC14_07210 ENOG4105VB6 UPF0109 protein FOC14_07230 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC14_07235 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC14_07250 ENOG4105CHR reductase FOC14_07255 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC14_07270 ENOG4105CB5 ATP-dependent DNA helicase recG FOC14_07275 ENOG4105DP4 dak2 domain fusion protein ylov FOC14_07280 ENOG4108ZAA Alkaline-shock protein FOC14_07295 ENOG4105FJ0 thiamine FOC14_07300 ENOG4105DJV ribulose-phosphate 3-epimerase FOC14_07305 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC14_07310 ENOG4105D9P serine threonine protein kinase FOC14_07315 ENOG4108ZF3 Phosphatase FOC14_07325 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC14_07335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC14_07340 ENOG4105C25 Primosomal protein n' FOC14_07345 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC14_07365 ENOG4105DSJ YicC domain protein FOC14_07375 ENOG4105F23 Fibronectin-binding protein FOC14_07380 ENOG4105DC7 peptidase M24 FOC14_07435 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC14_07460 ENOG4105C34 Pseudouridine synthase FOC14_07485 ENOG4105DBK s4 domain protein FOC14_07490 ENOG41067XK integral membrane protein FOC14_07500 ENOG4105DFA alanine racemase domain protein FOC14_07505 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC14_07510 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC14_07520 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_07530 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC14_07535 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC14_07540 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC14_07545 ENOG4105D4A Cell wall formation (By similarity) FOC14_07550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC14_07555 ENOG4105CNI cell division protein FtsW FOC14_07570 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC14_07575 ENOG4105CJN penicillin-binding protein FOC14_07580 ENOG4105CJN penicillin-binding protein FOC14_07585 ENOG41068DC Essential cell division protein (By similarity) FOC14_07625 ENOG4105KNH Nucleic acid-binding protein FOC14_07675 ENOG4105XSJ toxin secretion phage lysis holin FOC14_07755 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC14_07765 ENOG4105CAR Terminase, large subunit FOC14_07850 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC14_07865 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_07910 ENOG4108IMY Transcriptional regulator FOC14_07930 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC14_07940 ENOG41063PX domain protein FOC14_07945 ENOG4105D78 K07001 NTE family protein FOC14_07950 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC14_07960 ENOG4106H78 methyltransferase FOC14_07980 ENOG4107TB6 phosphoglycerate mutase FOC14_07995 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC14_08045 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC14_08050 ENOG4105CNI cell division protein FtsW FOC14_08065 ENOG4108IAB Phoh family FOC14_08085 ENOG4105QA2 FOC14_08090 ENOG4105CI3 gtp-binding protein typa FOC14_08100 ENOG4105ECY inositol monophosphatase FOC14_08120 ENOG4105CXN decarboxylase FOC14_08165 ENOG4105C7S Dehydrogenase FOC14_08170 ENOG4105CPP Dehydrogenase, E1 component FOC14_08185 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC14_08200 ENOG4105CN5 Metallo-Beta-Lactamase FOC14_08205 ENOG4107ZYR domain protein FOC14_08240 ENOG4108XRC Protein of unknown function (DUF458) FOC14_08245 ENOG4107IN1 Protein of unknown function (DUF1797) FOC14_08260 ENOG4105EPM Diguanylate phosphodiesterase FOC14_08265 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC14_08280 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC14_08290 ENOG4105UIN FOC14_08345 ENOG4108HGU Histidine kinase FOC14_08355 ENOG4105CHM Aminotransferase FOC14_08360 ENOG4105FKQ transcriptional regulator FOC14_08365 ENOG4105EG2 ABC transporter, permease FOC14_08375 ENOG4107FKK extracellular solute-binding protein family 1 FOC14_08385 ENOG4105CG3 alpha amylase, catalytic region FOC14_08430 ENOG4105CHU acetyl-coa acetyltransferase FOC14_08470 ENOG4105K7K Transcriptional regulator FOC14_08475 ENOG4105DTD Dehydrogenase FOC14_08485 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FOC14_08495 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC14_08520 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC14_08540 ENOG4106TD9 Diguanylate cyclase FOC14_08560 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC14_08575 ENOG4105CID antiterminator FOC14_08585 ENOG4105FDP GntR family transcriptional regulator FOC14_08595 ENOG4105CE4 GlcNAc 6-P deacetylase FOC14_08630 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC14_08635 ENOG4105PTM secreted protein FOC14_08640 ENOG4105J7I hydrolase FOC14_08650 ENOG4105G6R Stage v sporulation protein ae FOC14_08660 ENOG4105CZ3 stage V sporulation protein ad FOC14_08665 ENOG41090VF Stage v sporulation protein ac FOC14_08685 ENOG4105C8J )-transporter FOC14_08690 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_08700 ENOG41082AN stage II sporulation protein FOC14_08705 ENOG4105DZ1 carboxypeptidase FOC14_08710 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_08715 ENOG4105DVE abc transporter atp-binding protein FOC14_08745 ENOG4105D7N magnesium and cobalt transport protein CorA FOC14_08770 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC14_08780 ENOG4105I3K Ferric uptake regulator, Fur family FOC14_08785 ENOG4105MZ9 stage II sporulation protein m FOC14_08805 ENOG4105CPC Aldo Keto reductase FOC14_08815 ENOG4105RHY Pfam:UPF0157 FOC14_08835 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC14_08845 ENOG4105ETE Transcriptional regulator (LacI family FOC14_08850 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC14_08870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC14_08875 ENOG4108R6K riboflavin synthase, subunit alpha FOC14_08895 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC14_08900 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_08905 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_08910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC14_08920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_08930 ENOG4105DFD Na H antiporter FOC14_08935 ENOG4105CGH 5'-nucleotidase FOC14_08975 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC14_08990 ENOG4108IXY short-chain dehydrogenase reductase FOC14_09000 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_09005 ENOG4105EJQ L-serine dehydratase FOC14_09025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC14_09035 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC14_09040 ENOG4105D9U N-acetyltransferase FOC14_09055 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC14_09060 ENOG4108QEG Membrane FOC14_09065 ENOG4105CDA abc transporter atp-binding protein FOC14_09070 ENOG4105E5Q amino acid AbC transporter FOC14_09075 ENOG4108HW3 (ABC) transporter FOC14_09085 ENOG4105G7B Protein of unknown function (DUF2992) FOC14_09100 ENOG4105C7S Dehydrogenase FOC14_09105 ENOG4105CPP Dehydrogenase, E1 component FOC14_09125 ENOG4107RDP Dehydrogenase FOC14_09135 ENOG4108JUB Transcriptional regulator FOC14_09145 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC14_09160 ENOG4107QQR Sporulation FOC14_09165 ENOG4105S1Z Stage IV sporulation protein B FOC14_09170 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC14_09180 ENOG4105DX0 Hemolysin A FOC14_09190 ENOG4105CTB Polyprenyl synthetase FOC14_09215 ENOG4108ZSR alkaline shock protein FOC14_09220 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC14_09245 ENOG410644B Stage III sporulation protein af FOC14_09255 ENOG4105KQ4 Stage iii sporulation protein ad FOC14_09260 ENOG4108CQH stage III sporulation protein AC FOC14_09265 ENOG4105KR5 Stage iii sporulation protein FOC14_09270 ENOG4105CD2 stage iii sporulation protein aa FOC14_09295 ENOG4105DC7 peptidase M24 FOC14_09310 ENOG4105CBJ Metal-dependent enzyme FOC14_09320 ENOG4107YBY Hydrolase FOC14_09340 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC14_09345 ENOG4105WZW rhodanese family FOC14_09365 ENOG41080TC multidrug resistance protein FOC14_09400 ENOG4105CJ1 ABC, transporter FOC14_09405 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC14_09435 ENOG4105C0D helicase FOC14_09555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC14_09560 ENOG4105C3R Methionine synthase FOC14_09570 ENOG4105C28 cystathionine FOC14_09575 ENOG4105C28 cystathionine FOC14_09595 ENOG4105C5X domain protein FOC14_09605 ENOG4105DKQ ROK family FOC14_09615 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC14_09630 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC14_09635 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC14_09640 ENOG4105E2Z phosphate ABC transporter (Permease FOC14_09645 ENOG4105C8U phosphate abc transporter FOC14_09650 ENOG4105PWN phosphate abc transporter FOC14_09655 ENOG4107RF6 penicillin-binding protein FOC14_09665 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_09690 ENOG4105N80 Ferric uptake regulator, Fur family FOC14_09700 ENOG4105FDK ABC transporter FOC14_09705 ENOG4108JYZ YitT family FOC14_09710 ENOG41069ZM Protein of unknown function (DUF2624) FOC14_09735 ENOG4105EGD dinuclear metal center protein, YbgI family FOC14_09750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_09755 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC14_09785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC14_09790 ENOG4105KG3 cytidine deaminase FOC14_09795 ENOG4107YR5 Diacylglycerol kinase FOC14_09805 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC14_09810 ENOG4105C9A Phoh family FOC14_09820 ENOG41068P3 sporulation protein YqfC FOC14_09825 ENOG4105KTH gatB Yqey FOC14_09835 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC14_09840 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC14_09860 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC14_09870 ENOG4105CSA Coproporphyrinogen iii oxidase FOC14_09875 ENOG4105KVH Transcriptional regulator FOC14_09900 ENOG4105TQK DNA polymerase iii, delta' subunit FOC14_09910 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC14_09915 ENOG4108UK2 deaminase FOC14_09920 ENOG4105KQC Competence protein FOC14_09930 ENOG4105DXX methyltransferase FOC14_09940 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC14_09950 ENOG410812S Rna-binding protein FOC14_09960 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC14_09965 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC14_09980 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_10000 ENOG4108TVJ Nitroreductase FOC14_10015 ENOG4105G6Z alkaline phosphatase FOC14_10025 ENOG4108MUZ hydrolase FOC14_10060 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC14_10065 ENOG4105MIR Phenylalanine 4-monooxygenase FOC14_10115 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC14_10120 ENOG4108V5C ABC transporter FOC14_10130 ENOG4108EKI Dehydrogenase FOC14_10135 ENOG4105C28 cystathionine FOC14_10165 ENOG4107XRG penicillin-binding protein FOC14_10180 ENOG4105CFP Peptidase U32 FOC14_10185 ENOG4105XYU peptidase (U32 family) FOC14_10190 ENOG4108VQJ O-methyltransferase FOC14_10195 ENOG4105HHA aminodeoxychorismate lyase FOC14_10215 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_10225 ENOG4105C02 permease FOC14_10240 ENOG41060CR FOC14_10245 ENOG4105C7H Helicase, RecD TraA family FOC14_10255 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC14_10260 ENOG4105C3J Cysteine desulfurase FOC14_10270 ENOG4105D1H recombination factor protein RarA FOC14_10275 ENOG4108VCI transcription factor, rsfa family FOC14_10280 ENOG4105CUZ uba thif-type nad fad binding protein FOC14_10290 ENOG4105CUT histidyl-tRNA synthetase FOC14_10300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC14_10310 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC14_10315 ENOG41076HS cation diffusion facilitator family transporter FOC14_10320 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC14_10330 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC14_10335 ENOG4108QG2 Membrane FOC14_10345 ENOG4105VIE preprotein translocase, subunit YajC FOC14_10360 ENOG41061AI Protein of unknown function (DUF2905) FOC14_10375 ENOG4108HUF Transporter FOC14_10385 ENOG4108IPJ Membrane FOC14_10390 ENOG4108IPJ Membrane FOC14_10395 ENOG41082BM Transcriptional regulator, arsr family FOC14_10420 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC14_10425 ENOG4108IYU L-aspartate oxidase FOC14_10440 ENOG4108RPX mosc domain containing protein FOC14_10445 ENOG4105CQC Prephenate dehydratase FOC14_10475 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC14_10490 ENOG4105X36 (ribosomal) protein FOC14_10500 ENOG4105C03 ribonuclease FOC14_10515 ENOG4107QMS site-determining protein FOC14_10530 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC14_10535 ENOG4105DFF Rod shape-determining protein mreb FOC14_10555 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC14_10560 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC14_10570 ENOG41068KH stage VI sporulation protein D FOC14_10580 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC14_10605 ENOG4105K56 Transcriptional regulator FOC14_10625 ENOG4108IUQ atp-dependent protease FOC14_10650 ENOG4108QCI YvbH-like oligomerisation region FOC14_10670 ENOG4105M59 Phosphodiesterase, mj0936 family FOC14_10675 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC14_10685 ENOG4108XJQ germination protein FOC14_10695 ENOG4108PCX Major Facilitator FOC14_10705 ENOG4105KBX Transcriptional regulator, TetR family FOC14_10720 ENOG4105PFC Transcriptional regulator FOC14_10735 ENOG4105DZC cytosine deaminase FOC14_10740 ENOG4105DZC cytosine deaminase FOC14_10745 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC14_10750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_10765 ENOG4108JQ7 (ABC) transporter FOC14_10775 ENOG4105DY9 regulatoR FOC14_10790 ENOG41067S9 phage shock protein C, PspC FOC14_10795 ENOG4108JCI Transcriptional regulator FOC14_10805 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC14_10810 ENOG4108Z40 Transcriptional regulator FOC14_10815 ENOG4105RHA ABC transporter, permease FOC14_10820 ENOG4108IUX (ABC) transporter FOC14_10825 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC14_10835 ENOG4105E14 MotA TolQ exbB proton channel FOC14_10840 ENOG4108VXD carboxy-peptidase FOC14_10850 ENOG4105E33 succinate dehydrogenase FOC14_10860 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC14_10875 ENOG4105K63 Thioredoxin FOC14_10880 ENOG4105C10 Electron transfer flavoprotein FOC14_10885 ENOG4105BZJ Electron transfer flavoprotein FOC14_10890 ENOG41060WC Enoyl-CoA hydratase FOC14_10895 ENOG4107Z3H Transcriptional regulator, TetR family FOC14_10900 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_10910 ENOG4105J76 Periplasmic binding protein FOC14_10915 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC14_10955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_10965 ENOG4105DR4 Methyltransferase FOC14_10980 ENOG4105KFN sortase, SrtB family FOC14_10985 ENOG4105E0A ABC, transporter FOC14_11000 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC14_11010 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC14_11020 ENOG4105FE9 pseudouridine synthase FOC14_11030 ENOG4105DCG PHP domain protein FOC14_11065 ENOG4105C5S asparaginyl-tRNA synthetase FOC14_11070 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC14_11080 ENOG4108RWN rrna methyltransferase FOC14_11115 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_11120 ENOG4105CW7 secretion protein, HlyD family FOC14_11125 ENOG4108JGH Tetr family transcriptional regulator FOC14_11130 ENOG4105CN9 Peptidase m42 family protein FOC14_11150 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC14_11155 ENOG4105C22 threonyL-tRNA synthetase FOC14_11160 ENOG4108TDW sporulation protein YtxC FOC14_11180 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC14_11190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC14_11195 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC14_11205 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC14_11210 ENOG4105C2M dna polymerase I FOC14_11215 ENOG4105BZU Histidine kinase FOC14_11220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_11235 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC14_11240 ENOG4105BZN citrate synthase FOC14_11250 ENOG4108REF Sporulation integral membrane protein ytvi FOC14_11255 ENOG4105FS0 cytoplasmic membrane protein FOC14_11280 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC14_11285 ENOG4105C6K Malic enzyme FOC14_11290 ENOG4105C0B DNA polymerase III (alpha subunit) FOC14_11295 ENOG4105VV2 FOC14_11305 ENOG4105SFS phosphoesterase RecJ domain protein FOC14_11335 ENOG4105DC7 peptidase M24 FOC14_11370 ENOG4105Z7P Acetyltransferase (GNAT) family FOC14_11375 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC14_11385 ENOG4105VZ8 Transcriptional regulator FOC14_11405 ENOG4107YZX Universal stress protein FOC14_11445 ENOG4108JYZ YitT family FOC14_11465 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC14_11475 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC14_11480 ENOG4105KBJ sporulation protein ytfj FOC14_11495 ENOG4105EFZ amidohydrolase FOC14_11505 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC14_11530 ENOG4106KR7 LysR family Transcriptional regulator FOC14_11550 ENOG4105C28 cystathionine FOC14_11570 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC14_11580 ENOG4105EMN RNA polymerase sigma factor FOC14_11600 ENOG4105F1V Acetoin utilization protein FOC14_11605 ENOG4105W87 Cbs domain FOC14_11610 ENOG4105DGU Histone deacetylase FOC14_11620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_11630 ENOG4107SNB ankyrin repeat protein YahD FOC14_11635 ENOG4105EP9 oxidoreductase FOC14_11665 ENOG4105ETE Transcriptional regulator (LacI family FOC14_11685 ENOG4105C88 aminopeptidase FOC14_11730 ENOG4108VDD TRNA binding domain protein FOC14_11760 ENOG4105C8F Beta-lactamase domain protein FOC14_11775 ENOG4108V15 phosphotransferase enzyme family FOC14_11780 ENOG4108IUM Glycogen debranching enzyme FOC14_11795 ENOG4105YW5 deoR family transcriptional regulator FOC14_11810 ENOG4105CBX hi0933 family FOC14_11845 ENOG4108VJ1 Transcriptional regulator (CarD family FOC14_11850 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC14_11855 ENOG4105CSC Glucose uptake protein FOC14_11870 ENOG4108ZAF Molybdopterin FOC14_11875 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC14_11880 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_11890 ENOG4105D06 uba thif-type nad fad binding protein FOC14_11915 ENOG41085GJ domain protein FOC14_11925 ENOG4105DWV Homoserine O-trans-acetylase FOC14_11935 ENOG4108B31 Spore germination protein FOC14_11970 ENOG410605W Major Facilitator FOC14_11975 ENOG4107S91 Sodium hydrogen exchanger FOC14_11980 ENOG4105NCW Trka-c domain protein FOC14_11995 ENOG4105C19 ABC transporter FOC14_12015 ENOG4105N5T Radical SAM Protein FOC14_12025 ENOG4105DA5 (ABC) transporter FOC14_12055 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC14_12060 ENOG4108Z0R Transferase FOC14_12065 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC14_12070 ENOG4105BZF Glycosyl transferase (Group 1 FOC14_12080 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC14_12130 ENOG4105EGD dinuclear metal center protein, YbgI family FOC14_12135 ENOG4105BZU Histidine kinase FOC14_12140 ENOG4105BZU Histidine kinase FOC14_12145 ENOG4107S9D Alpha beta hydrolase FOC14_12165 ENOG4105D2X ABC transporter substrate-binding protein FOC14_12175 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC14_12230 ENOG4108V2W Carbonate dehydratase FOC14_12235 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC14_12240 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC14_12285 ENOG41087YS Phage shock protein A FOC14_12320 ENOG4105BZU Histidine kinase FOC14_12325 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_12350 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC14_12355 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC14_12390 ENOG4107ZTW SNARE associated Golgi FOC14_12405 ENOG4105C19 ABC transporter FOC14_12410 ENOG41086D8 Transcriptional regulator FOC14_12450 ENOG4105C6Z Gluconate FOC14_12455 ENOG4105FDP GntR family transcriptional regulator FOC14_12475 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC14_12505 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_12515 ENOG4108IPT Naphthoate synthase FOC14_12520 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC14_12525 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC14_12530 ENOG4105E4F Isochorismate synthase FOC14_12535 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC14_12545 ENOG4105VEQ Cold shock protein FOC14_12565 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC14_12575 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC14_12595 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_12690 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC14_12725 ENOG4105KT7 mgtC SapB transporter FOC14_12730 ENOG4107PBV potassium channel FOC14_12740 ENOG4107QYV phosphohexose isomerase FOC14_12745 ENOG4105WG9 Conserved Protein FOC14_12755 ENOG4105CHM Aminotransferase FOC14_12760 ENOG4108ZB6 transcriptional regulator AsnC family FOC14_12765 ENOG4105C5I Dehydrogenase FOC14_12770 ENOG4108MUZ hydrolase FOC14_12780 ENOG4105C87 Aminotransferase class I and II FOC14_12790 ENOG4105Y38 Kinase-associated protein B FOC14_12800 ENOG4107R3E Citrate transporter FOC14_12815 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FOC14_12820 ENOG4105KA0 thioesterase Superfamily protein FOC14_12840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC14_12860 ENOG41069ER domain protein FOC14_12875 ENOG4105CEP NADH dehydrogenase FOC14_12905 ENOG4105EWC Purine nucleoside phosphorylase FOC14_12925 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC14_12950 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_12955 ENOG4105C4B ABC transporter, permease FOC14_12960 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC14_13005 ENOG41083MR nifu domain-containing protein FOC14_13020 ENOG4108W5N phosphatidylglycerophosphatase a FOC14_13030 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC14_13035 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC14_13050 ENOG4105CBT Fructose-1,6-bisphosphatase FOC14_13065 ENOG4105MMD transcriptional regulator FOC14_13070 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC14_13075 ENOG4107TXC Transcriptional regulator FOC14_13080 ENOG41090T1 Membrane FOC14_13105 ENOG4105FAA peptidase M23 FOC14_13115 ENOG4105KZD Domain of unknown function (DUF1805) FOC14_13120 ENOG4107R8B 5'-nucleotidase FOC14_13140 ENOG4105DIW FeS assembly protein SUFB FOC14_13145 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC14_13150 ENOG4105C9B Cysteine desulfurase FOC14_13155 ENOG4105JRK feS assembly protein SufD FOC14_13160 ENOG4105C3K feS assembly ATPase SufC FOC14_13165 ENOG4105D01 (LipO)protein FOC14_13170 ENOG4105D01 (LipO)protein FOC14_13175 ENOG4108UMI ABC transporter, permease FOC14_13210 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC14_13255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_13280 ENOG4108W8B Beta-lactamase domain protein FOC14_13285 ENOG4105C1G acyl-Coa dehydrogenase FOC14_13290 ENOG4105CHU acetyl-coa acetyltransferase FOC14_13305 ENOG4105DZ1 carboxypeptidase FOC14_13325 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC14_13340 ENOG4108SUT Major Facilitator Superfamily FOC14_13345 ENOG4107R7I amino acid FOC14_13355 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC14_13365 ENOG4107AYK membrAne FOC14_13400 ENOG4107ZTW SNARE associated Golgi FOC14_13410 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC14_13415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_13420 ENOG4105BZU Histidine kinase FOC14_13430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC14_13445 ENOG4105VG1 fes assembly suf system protein FOC14_13450 ENOG4105D4Y metalloprotease FOC14_13470 ENOG4107S91 Sodium hydrogen exchanger FOC14_13475 ENOG4105NCW Trka-c domain protein FOC14_13485 ENOG4108RMU ferritin dps family protein FOC14_13500 ENOG4108URH decarboxylase FOC14_13520 ENOG4105D9N nucleoside FOC14_13525 ENOG4105D9N nucleoside FOC14_13540 ENOG4108RYK Nad-dependent epimerase dehydratase FOC14_13555 ENOG4105CV8 reductase FOC14_13560 ENOG4105F27 Major Facilitator FOC14_13565 ENOG4105KVH Transcriptional regulator FOC14_13580 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC14_13585 ENOG4105D4A Cell wall formation (By similarity) FOC14_13595 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_13605 ENOG4105WMR Protein CrcB homolog FOC14_13610 ENOG4105WMR Protein CrcB homolog FOC14_13625 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC14_13630 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOC14_13645 ENOG4108IPW abc transporter atp-binding protein FOC14_13650 ENOG4105CM4 permease protein FOC14_13680 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC14_13690 ENOG4105XZU Preprotein translocase, subunit SecG FOC14_13695 ENOG41067MG lrgb family FOC14_13795 ENOG4105EFC phage portal protein HK97 family FOC14_13820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC14_13830 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC14_13835 ENOG4105CP7 Triose-phosphate isomerase FOC14_13860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_13880 ENOG41090VF Stage v sporulation protein ac FOC14_13885 ENOG4105CZ3 stage V sporulation protein ad FOC14_13900 ENOG4105H67 Protein of unknown function (DUF421) FOC14_13905 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC14_13910 ENOG4105KRI phosphocarrier protein (HPr FOC14_13920 ENOG4105CHW UPF0052 protein FOC14_13930 ENOG4108Z4K mutator MutT protein FOC14_13940 ENOG4105C3M thioredoxin reductase FOC14_13950 ENOG4108S4C acetyltransferase FOC14_13970 ENOG41086DT Membrane protein of unknown function FOC14_13980 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC14_13985 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC14_13990 ENOG4105D7V transposase FOC14_14005 ENOG4107TXC Transcriptional regulator FOC14_14030 ENOG4105HMI Membrane FOC14_14035 ENOG4105DUM transcriptional regulator, lysR family FOC14_14045 ENOG4108WS4 fmn reductase FOC14_14060 ENOG4105BZ1 (ABC) transporter FOC14_14070 ENOG4105CN1 protease FOC14_14075 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC14_14080 ENOG4105CAK Cell division ATP-binding protein ftsE FOC14_14100 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC14_14105 ENOG4105MS2 ribosomal subunit Interface protein FOC14_14110 ENOG4105VEQ Cold shock protein FOC14_14115 ENOG41081UC Inherit from COG: Competence protein FOC14_14130 ENOG4105KVH Transcriptional regulator FOC14_14140 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC14_14145 ENOG4108KGH TRANSCRIPTIONal FOC14_14150 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC14_14155 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC14_14160 ENOG4105ESV Glycosyl transferase, family 4 FOC14_14170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC14_14185 ENOG410901P UPF0249 protein FOC14_14190 ENOG4105F8D glycoside hydrolase family 4 FOC14_14195 ENOG4105VCP PTS System FOC14_14200 ENOG4105CK1 PTS System FOC14_14210 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC14_14215 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC14_14220 ENOG4105VCP PTS System FOC14_14230 ENOG4105VZJ PTS System FOC14_14245 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_14250 ENOG4105ECB domain protein FOC14_14255 ENOG4107RSM transcriptional regulator FOC14_14295 ENOG4105DAA L-lactate FOC14_14305 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC14_14315 ENOG4105E0M Sulfatase FOC14_14345 ENOG4105C94 Transporter FOC14_14350 ENOG41069ER domain protein FOC14_14375 ENOG4105KBK Zinc finger, swim domain protein FOC14_14380 ENOG4105C0D helicase FOC14_14410 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_14420 ENOG4107RBB ABC transporter, permease FOC14_14425 ENOG4105C19 ABC transporter FOC14_14445 ENOG4105CXY transporter FOC14_14460 ENOG4105BZU Histidine kinase FOC14_14465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_14470 ENOG4105CMR udp-glucose 4-epimerase FOC14_14485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC14_14490 ENOG4105EY8 ABC transporter FOC14_14545 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC14_14560 ENOG4105FRN stage II sporulation protein FOC14_14595 ENOG4106778 Protein of unknown function (DUF1146) FOC14_14600 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC14_14605 ENOG4105C8S subunit m FOC14_14610 ENOG4105D65 subunit l FOC14_14635 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC14_14640 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC14_14650 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC14_14655 ENOG4105BZU Histidine kinase FOC14_14705 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC14_14710 ENOG41062M3 atp synthase FOC14_14740 ENOG4108YZG isomerase FOC14_14755 ENOG4108VGI doxx family FOC14_14760 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC14_14775 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC14_14785 ENOG4108ZXQ stage ii sporulation protein r FOC14_14790 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC14_14795 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC14_14810 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC14_14815 ENOG4105CBT Fructose-1,6-bisphosphatase FOC14_14820 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC14_14855 ENOG4105C1G acyl-Coa dehydrogenase FOC14_14860 ENOG4105C1G acyl-Coa dehydrogenase FOC14_14865 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC14_14875 ENOG4105DF6 Fe-S oxidoreductase FOC14_14890 ENOG4105BZU Histidine kinase FOC14_14915 ENOG4105BZU Histidine kinase FOC14_14920 ENOG4105KCT ABC transporter FOC14_14925 ENOG4108M15 ABC transporter FOC14_14930 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_14940 ENOG4105IIU Aminopeptidase FOC14_14960 ENOG4105EMN RNA polymerase sigma factor FOC14_14970 ENOG410684U Domain of unknown function (DUF1934) FOC14_14990 ENOG4105CYW agmatinase FOC14_15000 ENOG4105DXB Major Facilitator superfamily FOC14_15005 ENOG4107SWG transcriptional regulator MERR family FOC14_15010 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC14_15015 ENOG4105BZ4 penicillin-binding protein FOC14_15020 ENOG4108XFG YwhD family FOC14_15025 ENOG4108Z4T Peptidase M50 FOC14_15030 ENOG41069HH 4-oxalocrotonate tautomerase FOC14_15035 ENOG4105DCI Phosphohydrolase FOC14_15040 ENOG4108MES Periplasmic binding protein FOC14_15045 ENOG4105E0A ABC, transporter FOC14_15050 ENOG4105EHG Permease protein FOC14_15065 ENOG4108VCI transcription factor, rsfa family FOC14_15080 ENOG4108IJ2 phosphate acetyltransferase FOC14_15095 ENOG4108VKI Cell wall hydrolase FOC14_15125 ENOG410667J hydrolase FOC14_15130 ENOG4105VCH membrane FOC14_15140 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC14_15145 ENOG4105CJ1 ABC, transporter FOC14_15150 ENOG41090WU lipolytic protein G-D-S-L family FOC14_15165 ENOG4105D6E homoserine dehydrogenase FOC14_15190 ENOG4108Y4K DNA-binding transcriptional activator FOC14_15200 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_15210 ENOG4105DWF phosphomethylpyrimidine kinase FOC14_15215 ENOG4105BZU Histidine kinase FOC14_15220 ENOG4105VCD cytoplasmic protein FOC14_15225 ENOG4105D22 carbon starvation protein FOC14_15230 ENOG4105DY9 regulatoR FOC14_15235 ENOG41079KZ Major Facilitator Superfamily FOC14_15255 ENOG4105EN6 Membrane FOC14_15260 ENOG4106YBV Methyl-accepting chemotaxis FOC14_15270 ENOG4108S4H thioesterase Superfamily protein FOC14_15280 ENOG4105JEU Glycosyl transferase, family 2 FOC14_15285 ENOG4105C5H ABC transporter FOC14_15305 ENOG4105CKK Glycosyl transferase, family 2 FOC14_15310 ENOG41067SE Tetr family transcriptional regulator FOC14_15320 ENOG4105E0X reductase FOC14_15325 ENOG4106F5Q Membrane FOC14_15340 ENOG4105DY9 regulatoR FOC14_15345 ENOG4108HRK Histidine kinase FOC14_15350 ENOG4107RGD Major Facilitator superfamily FOC14_15365 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_15375 ENOG4105IW1 AmiS UreI transporter FOC14_15385 ENOG4105CMR udp-glucose 4-epimerase FOC14_15390 ENOG4108UT2 hemolysin iii FOC14_15400 ENOG4105C1J atp-dependent rna helicase FOC14_15415 ENOG4105DPN Oligoendopeptidase f FOC14_15435 ENOG4105C0H protease FOC14_15440 ENOG4105Q2H domain protein FOC14_15455 ENOG4105BZU Histidine kinase FOC14_15460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_15490 ENOG4105CDU Replicative dna helicase FOC14_15500 ENOG4105BZR domain protein FOC14_15505 ENOG4108XMW Membrane FOC14_15515 ENOG4108UUM single-stranded DNA-binding protein FOC14_15525 ENOG4105C3G gtp-binding protein FOC14_15530 ENOG4105VDK protein, conserved in bacteria FOC14_15535 ENOG4105D8X mechanosensitive ion channel FOC14_15540 ENOG4108ZDA Sporulation protein YyaC FOC14_15545 ENOG4105FA0 parb-like partition protein FOC14_15550 ENOG4107QJE Chromosome Partitioning Protein FOC14_15570 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC14_15580 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC14_15600 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC14_15605 ENOG410848D S4 domain protein YaaA FOC14_15620 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC14_15655 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC14_15690 ENOG4105ZMH deoxynucleoside kinase FOC14_15700 ENOG4105GTG Isochorismatase FOC14_15705 ENOG4108Z6B deaminase FOC14_15715 ENOG4105C6E dna polymerase iii FOC14_15735 ENOG41067KS pro-sigma K processing FOC14_15770 ENOG4105CXN decarboxylase FOC14_15780 ENOG4105FA2 dna polymerase iii FOC14_15785 ENOG4105MA4 psp1 domain protein FOC14_15795 ENOG41060K3 Methyltransferase FOC14_15805 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC14_15810 ENOG4105KRN Transcriptional regulator, abrb family FOC14_15820 ENOG4105F8V Hydrolase, tatD family FOC14_15825 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC14_15835 ENOG4105XFA sporulation peptidase YabG FOC14_15840 ENOG4105W42 Veg protein FOC14_15855 ENOG4105DFT pur operon repressor FOC14_15860 ENOG4105KME endoribonuclease L-psp FOC14_15875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOC14_15880 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC14_15890 ENOG4108JA2 transcriptioN-repair coupling factor FOC14_15895 ENOG4108M14 stage v sporulation protein t FOC14_15905 ENOG4108IY2 MazG family FOC14_15910 ENOG41082I2 s4 domain protein FOC14_15915 ENOG4105VYY sporulation protein yabp FOC14_15930 ENOG41060GV RNA binding s1 domain protein FOC14_15950 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC14_15955 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC14_15960 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC14_15975 ENOG4105C6T cysteine synthase FOC14_15980 ENOG4105CRQ synthase (Component I) FOC14_15985 ENOG4105DDQ anthranilate synthase FOC14_15990 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC14_15995 ENOG4105EEI dihydropteroate synthase FOC14_16000 ENOG4105KRF dihydroneopterin aldolase FOC14_16005 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC14_16015 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC14_16045 ENOG4108Z0C Uvrb UvrC protein FOC14_16060 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC14_16070 ENOG4105CTP PilT protein domain protein FOC14_16090 ENOG4105D7W serine acetyltransferase FOC14_16105 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC14_16110 ENOG4105M0M Tetracycline resistance protein FOC14_16115 ENOG4105QIV RNA polymerase FOC14_16130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC14_16155 ENOG4107Y49 methyltransferase FOC14_16165 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC14_16170 ENOG4105XPM ribosomal protein FOC14_16275 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC14_16300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC14_16310 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_16320 ENOG41067V7 50S ribosomal protein L36 FOC14_16350 ENOG4108JJB ABC transporter FOC14_16355 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC14_16360 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC14_16385 ENOG4105D1F ATP-binding protein FOC14_16400 ENOG4108NMV polysaccharide deacetylase FOC14_16480 ENOG4105C8B TIGR00159 family FOC14_16485 ENOG4107U5W ybbr family FOC14_16500 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC14_16505 ENOG4108VQT Alpha beta hydrolase fold protein FOC14_16525 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC14_16530 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC14_16565 ENOG4108UMI ABC transporter, permease FOC14_16570 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_16575 ENOG4105D01 (LipO)protein FOC14_16580 ENOG4105EE1 crotonyl-CoA reductase FOC14_16590 ENOG4105IQ5 FAD linked oxidase domain protein FOC14_16605 ENOG4105C2C drug resistance transporter, Bcr CflA FOC14_16620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_16625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_16630 ENOG4105C3U ABC transporter FOC14_16635 ENOG4108JQ7 (ABC) transporter FOC14_16665 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC14_16670 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC14_16680 ENOG4105II7 pyrroline-5-carboxylate reductase FOC14_16685 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC14_16695 ENOG4105E0C molybdate abc transporter FOC14_16705 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC14_16715 ENOG4105EGI Transcriptional regulator FOC14_16735 ENOG4105F6E Acyl-transferase FOC14_16755 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC14_16765 ENOG4108RE7 deoxyribonuclease FOC14_16770 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC14_16795 ENOG4105C5H ABC transporter FOC14_16810 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC14_16820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_16825 ENOG4105C3U ABC transporter FOC14_16830 ENOG4108JQ7 (ABC) transporter FOC14_16850 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC14_16855 ENOG4105ERH Fumarylacetoacetate hydrolase FOC14_16865 ENOG4108SC4 )-transporter FOC14_16875 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC14_16890 ENOG4107ZXI Rhomboid family FOC14_16900 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC14_16905 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC14_16915 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC14_17015 ENOG4105K8N protein family UPF0079, ATPase FOC14_17020 ENOG41072GX Peptidase M22 Glycoprotease FOC14_17025 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC14_17030 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC14_17035 ENOG4105C5H ABC transporter FOC14_17050 ENOG4108TYN CAAX amino terminal protease family protein FOC14_17070 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_17080 ENOG4105BZU Histidine kinase FOC14_17110 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC14_17150 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_17170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_17190 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC14_17195 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC14_17200 ENOG4105C83 adenylosuccinate lyase FOC14_17210 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC14_17235 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC14_17245 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC14_17270 ENOG4105C4R Atp-dependent dna helicase FOC14_17295 ENOG4108W2Y isochorismatase FOC14_17300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC14_17305 ENOG4108UMI ABC transporter, permease FOC14_17310 ENOG4105D01 (LipO)protein FOC14_17330 ENOG410834F Transcriptional regulator FOC14_17355 ENOG4105CBD Diacylglycerol kinase FOC14_17360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC14_17365 ENOG4108JPW Aminotransferase FOC14_17375 ENOG4105C26 Dehydrogenase FOC14_17380 ENOG4105KPY Small multidrug resistance protein FOC14_17400 ENOG4105D9N nucleoside FOC14_17405 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC14_17420 ENOG4108W15 Protein of unknown function (DUF1456) FOC14_17435 ENOG4105DTQ mandelate racemase muconate lactonizing FOC14_17445 ENOG4105DFD Na H antiporter FOC14_17465 ENOG4105D3R alkyl hydroperoxide reductase FOC14_17470 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOC14_17480 ENOG4107W7X Aldolase FOC14_17485 ENOG4105EHG Permease protein FOC14_17490 ENOG4105DQ5 transport system permease protein FOC14_17495 ENOG4108V5C ABC transporter FOC14_17515 ENOG4106UIA FOC14_17520 ENOG4106UIA FOC14_17545 ENOG4105BZU Histidine kinase FOC14_17565 ENOG410756H nucleotidyltransferase FOC14_17570 ENOG4105D2S major facilitator superfamily FOC14_17585 ENOG4105E5Q amino acid AbC transporter FOC14_17590 ENOG4105EAB amino acid AbC transporter FOC14_17600 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_17605 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_17615 ENOG4105CI1 PTS System FOC14_17645 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC14_17660 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC14_17675 ENOG4105C5H ABC transporter FOC14_17700 ENOG41062JF Transcriptional regulator FOC14_17720 ENOG4105DEU major facilitator superfamily FOC14_17735 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FOC14_17750 ENOG4108N0M stress protein FOC14_17755 ENOG4106FN3 tellurium resistance protein FOC14_17760 ENOG4106FN3 tellurium resistance protein FOC14_17765 ENOG4107TS3 membrane protein, TerC FOC14_17770 ENOG4108TTB tellurium resistance protein FOC14_17790 ENOG4105KJF protein tyrosine phosphatase FOC14_17800 ENOG4107U9T Pfam:Ribonuclease_BN FOC14_17805 ENOG4105C59 p-type ATPase FOC14_17810 ENOG4108IPJ Membrane FOC14_17830 ENOG4107ZTW SNARE associated Golgi FOC14_17845 ENOG410606W general stress protein FOC14_17850 ENOG4105UPD Calcium Proton FOC14_17890 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC14_17895 ENOG4105VTR Integrase FOC14_17900 ENOG4108IMY Transcriptional regulator FOC14_18160 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC14_18170 ENOG4108JUB Transcriptional regulator FOC14_18180 ENOG4108IQI permease FOC14_18205 ENOG4105CSV Glutaminase FOC14_18215 ENOG4108A04 Beta-lactamase FOC14_18230 ENOG4105CKK Glycosyl transferase, family 2 FOC14_18240 ENOG4107QQG Dehydrogenase FOC14_18245 ENOG4105C3I Nad-dependent epimerase dehydratase FOC14_18265 ENOG4105F1A Pyruvate formate-lyase FOC14_18285 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC14_18290 ENOG4105ECP epimerase FOC14_18320 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC14_18325 ENOG4105CEN a g-specific adenine glycosylase FOC14_18330 ENOG4106BXE FOC14_18350 ENOG4105BZ1 (ABC) transporter FOC14_18355 ENOG4107NBY Membrane FOC14_18360 ENOG4105CBC glutamate synthase FOC14_18370 ENOG4108IUW ABC transporter FOC14_18390 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC14_18395 ENOG4105G5W regulator Fur family FOC14_18510 ENOG4108JQC penicillin-binding protein 1A FOC14_18515 ENOG4107ZQN disulfide bond FOC14_18525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC14_18535 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC14_18540 ENOG4105BZU Histidine kinase FOC14_18545 ENOG4105CYN Serine protein kinase FOC14_18565 ENOG4105C94 Transporter FOC14_18580 ENOG4105DZ6 Band 7 protein FOC14_18590 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC14_18600 ENOG4105D4T Citrate transporter FOC14_18620 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC14_18625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_18630 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC14_18635 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC14_18640 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC14_18645 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC14_18650 ENOG4108STX response regulator FOC14_18655 ENOG4105US7 Histidine kinase FOC14_18680 ENOG4108MRH transcriptional regulatory protein FOC14_18690 ENOG4105C6K Malic enzyme FOC14_18700 ENOG4108UZ3 Transporter FOC14_18705 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC14_18715 ENOG4105BZU Histidine kinase FOC14_18720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_18725 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC14_18730 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC14_18735 ENOG4108JB9 formate dehydrogenase FOC14_18755 ENOG4105CUB amino acid FOC14_18765 ENOG4105C59 p-type ATPase FOC14_18770 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC14_18805 ENOG41073R8 VanW family FOC14_18810 ENOG4108KGH TRANSCRIPTIONal FOC14_18815 ENOG4105D9N nucleoside FOC14_18820 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC14_18825 ENOG4105C37 (CBS) domain FOC14_18830 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_18835 ENOG4105DAA L-lactate FOC14_18850 ENOG4105DUX Transporter FOC14_18855 ENOG4108MES Periplasmic binding protein FOC14_18860 ENOG4105DQ5 transport system permease protein FOC14_18865 ENOG4108IHU transport system permease protein FOC14_18870 ENOG4105E0A ABC, transporter FOC14_18875 ENOG4105DMQ Methyltransferase FOC14_18885 ENOG4105EXW epimerase dehydratase FOC14_18895 ENOG4107T89 von Willebrand factor, type A FOC14_18900 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC14_18905 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_18920 ENOG4105BZU Histidine kinase FOC14_18925 ENOG4105D5Q Arginine ornithine antiporter FOC14_18930 ENOG4107414 GntR family transcriptional regulator FOC14_18935 ENOG4105C5Y PTS System FOC14_18940 ENOG4105CG3 alpha amylase, catalytic region FOC14_18955 ENOG4105E1K spore germination protein FOC14_18965 ENOG4105CRN Aminoglycoside phosphotransferase FOC14_18970 ENOG4105BZG amino acid carrier protein FOC14_18975 ENOG4105CDA abc transporter atp-binding protein FOC14_18980 ENOG4105CT1 (ABC) transporter FOC14_18985 ENOG4105EAD ABC transporter FOC14_18990 ENOG4105DRP amino acid AbC transporter FOC14_18995 ENOG4108IQI permease FOC14_19020 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC14_19025 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC14_19030 ENOG4105BZU Histidine kinase FOC14_19045 ENOG4105CHH sulfate transporter FOC14_19050 ENOG41068KF Universal stress protein FOC14_19060 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC14_19070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_19075 ENOG4108JQ7 (ABC) transporter FOC14_19085 ENOG4105CXY transporter FOC14_19090 ENOG41067TZ transcriptional regulator, MarR family FOC14_19100 ENOG4105ETE Transcriptional regulator (LacI family FOC14_19105 ENOG4108RVA ribokinase FOC14_19120 ENOG4105CNN ABC, transporter FOC14_19125 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC14_19130 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC14_19190 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_19195 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC14_19200 ENOG41069ER domain protein FOC14_19205 ENOG4105VZ8 Transcriptional regulator FOC14_19210 ENOG4107D63 FOC14_19220 ENOG4105DUX Transporter FOC14_19240 ENOG4105C85 amino acid FOC14_19245 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_19285 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC14_19290 ENOG4105E2S oxidase) subunit II FOC14_19295 ENOG4108IQI permease FOC14_19310 ENOG4106CAD Protein of unknown function (DUF3311) FOC14_19315 ENOG4105E1V na solute symporter FOC14_19330 ENOG4108NHD germination protein FOC14_19335 ENOG4105CE1 Ferrous iron transport protein b FOC14_19340 ENOG4105CE1 Ferrous iron transport protein b FOC14_19345 ENOG4105CE1 Ferrous iron transport protein b FOC14_19350 ENOG4105CVA phosphate FOC14_19355 ENOG4105C8U phosphate abc transporter FOC14_19360 ENOG4105E2Z phosphate ABC transporter (Permease FOC14_19485 ENOG41080XQ Signal transduction protein with cbs domains FOC14_19505 ENOG4105ETU transcriptional activator (TenA FOC14_19515 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC14_19525 ENOG4108VEU Thiamine monophosphate synthase FOC14_19530 ENOG41080HI glycine oxidase FOC14_19545 ENOG4105D06 uba thif-type nad fad binding protein FOC14_19550 ENOG4105DWF phosphomethylpyrimidine kinase FOC14_19600 ENOG4108INS Transcriptional regulator FOC14_19615 ENOG4105C7N Xanthine uracil vitamin C permease FOC14_19645 ENOG4105C5Y PTS System FOC14_19700 ENOG4107Y03 Nitroreductase FOC14_19705 ENOG4105ED1 spovr family FOC14_19730 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC14_19735 ENOG4105XTG Pfam:DUF156 FOC14_19740 ENOG4105VFE sira family FOC14_19745 ENOG4107TPS domain protein FOC14_19750 ENOG4105VFE sira family FOC14_19755 ENOG41085GJ domain protein FOC14_19765 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC14_19770 ENOG41087NI Sulfite exporter TauE/SafE FOC14_19780 ENOG4108KGH TRANSCRIPTIONal FOC14_19805 ENOG4105EMD TRANSCRIPTIONal FOC14_19810 ENOG4105VCP PTS System FOC14_19815 ENOG4105VZJ PTS System FOC14_19835 ENOG41069ER domain protein FOC14_19840 ENOG4107RBB ABC transporter, permease FOC14_19845 ENOG4105C19 ABC transporter FOC14_19875 ENOG4105WEF catalase FOC14_19910 ENOG4107T5V SNARE associated Golgi FOC14_19940 ENOG4105CUB amino acid FOC14_19945 ENOG4107RWR Sodium hydrogen exchanger FOC14_19955 ENOG4106KNT transcriptional regulator FOC14_19990 ENOG4108PCN EamA-like transporter family FOC14_19995 ENOG4108YXU transcriptional regulator AsnC family FOC14_20005 ENOG4105KPY Small multidrug resistance protein FOC14_20010 ENOG4105KPY Small multidrug resistance protein FOC14_20035 ENOG4105NF4 modulator of drug activity FOC14_20040 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC14_20045 ENOG4105E5W Transporter FOC14_20055 ENOG4107RKG DJ-1/PfpI family FOC14_20060 ENOG4105CH6 catalase FOC14_20070 ENOG4105D5Q Arginine ornithine antiporter FOC14_20075 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC14_20085 ENOG4105C26 Dehydrogenase FOC14_20090 ENOG4105BZ1 (ABC) transporter FOC14_20105 ENOG4105DRP amino acid AbC transporter FOC14_20110 ENOG4105CDA abc transporter atp-binding protein FOC14_20125 ENOG410839P FOC14_20160 ENOG4107FQX Alpha-acetolactate decarboxylase FOC14_20190 ENOG4105D4P Coproporphyrinogen iii oxidase FOC14_20205 ENOG4105CHH sulfate transporter FOC14_20245 ENOG4106AKK s-layer domain-containing protein FOC14_20255 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_20260 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_20275 ENOG4105CGU Enoyl-CoA hydratase FOC14_20295 ENOG4105DER m42 family FOC14_20315 ENOG4105CTU Proline racemase FOC14_20355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_20365 ENOG4108JQ7 (ABC) transporter FOC14_20370 ENOG4105PKS Excinuclease abc c subunit domain protein FOC14_20400 ENOG4105CSH Transporter FOC14_20410 ENOG4108MRH transcriptional regulatory protein FOC14_20460 ENOG4105CDU Replicative dna helicase FOC14_20490 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_20535 ENOG4107P5I polyketide synthase FOC14_20540 ENOG4108IG5 Transcriptional regulator FOC14_20560 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC14_20580 ENOG4105CMT Dihydroxyacetone kinase FOC14_20590 ENOG4105CMT Dihydroxyacetone kinase FOC14_20595 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC14_20600 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC14_20630 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC14_20695 ENOG4105WN5 stage II sporulation protein FOC14_20705 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC14_20715 ENOG4108MJI response regulator FOC14_20720 ENOG4105BZU Histidine kinase FOC14_20725 ENOG4105BZU Histidine kinase FOC14_20745 ENOG4105K8R UPF0145 protein FOC14_20775 ENOG4107VRP DNA repair exonuclease FOC14_20785 ENOG4105D7V transposase FOC14_20800 ENOG4108IND Tetr family transcriptional regulator FOC14_20805 ENOG4105EQ0 Major Facilitator superfamily FOC14_20825 ENOG4108MUZ hydrolase FOC14_20845 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC14_20860 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC14_20870 ENOG4105EMN RNA polymerase sigma factor FOC14_20895 ENOG4105C57 major facilitator superfamily FOC14_20900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_20910 ENOG4105EEM helicase FOC14_20915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_20940 ENOG4105K59 histidine triad (HIT) protein FOC14_20970 ENOG410905X membrane-flanked domain protein FOC14_21015 ENOG410905X membrane-flanked domain protein FOC14_21020 ENOG4105CKV Membrane FOC14_21025 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC14_21030 ENOG4105BZ4 penicillin-binding protein FOC14_21035 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC14_21045 ENOG4105C1Q protoporphyrinogen oxidase FOC14_21070 ENOG4105NA0 Transcriptional regulator FOC14_21085 ENOG4105ECB domain protein FOC14_21115 ENOG4106AXD FOC14_21120 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC14_21125 ENOG4105DF9 Lipoate-protein, ligase FOC14_21135 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_21165 ENOG4105CNA YD repeat protein FOC14_21200 ENOG4107TVP HD domain protein FOC14_21210 ENOG4108AEY RNA polymerase sigma factor FOC14_21215 ENOG41086D8 Transcriptional regulator FOC14_21230 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_21255 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC14_21260 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_21280 ENOG4105ZU5 s-layer protein FOC14_21285 ENOG4107QP3 malate synthase g FOC14_21300 ENOG4105VEQ Cold shock protein FOC14_21315 ENOG4105XVF Competence transcription factor FOC14_21330 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination FOC14_21335 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC14_21380 ENOG4105ERH Fumarylacetoacetate hydrolase FOC14_21405 ENOG4105CAQ asparagine synthetase FOC14_21410 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC14_21415 ENOG4105CH6 catalase FOC14_21440 ENOG4105QNR S1 RNA binding domain protein FOC14_21450 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_21460 ENOG4107AYK membrAne FOC14_21465 ENOG41073B9 FOC14_21475 ENOG4108KP7 hydrolase FOC14_21485 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC14_21510 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_21515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC14_21530 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC14_21545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC14_21550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC14_21560 ENOG4108JQ7 (ABC) transporter FOC14_21565 ENOG4105UQX Mate efflux family protein FOC14_21585 ENOG4108ZCF integral membrane protein FOC14_21595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_21605 ENOG4105DPN Oligoendopeptidase f FOC14_21615 ENOG4108Z18 K06886 hemoglobin FOC14_21620 ENOG4105MIX Adenylate cyclase FOC14_21635 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC14_21640 ENOG4105EMS pseudouridine synthase FOC14_21660 ENOG4105K64 Glycosyl transferase, family 2 FOC14_21680 ENOG4107TVC Glycosyl transferase, family 2 FOC14_21700 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC14_21705 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC14_21715 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC14_21765 ENOG4108WVJ 2'-5' rna ligase FOC14_21790 ENOG4105CK7 Sodium proline symporter FOC14_21800 ENOG4105DDQ anthranilate synthase FOC14_21895 ENOG4105C7S Dehydrogenase FOC14_21905 ENOG4105VZ8 Transcriptional regulator FOC14_21965 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC14_21975 ENOG4105DZ1 carboxypeptidase FOC14_21980 ENOG4105VFR signal peptidase FOC14_22015 ENOG4105C26 Dehydrogenase FOC14_22020 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_22025 ENOG4105F38 ABC transporter, permease FOC14_22030 ENOG4105D38 putrescine abc transporter FOC14_22035 ENOG4107RUE extracellular solute-binding protein family 1 FOC14_22045 ENOG4105EYF MMPL domain protein FOC14_22055 ENOG4108YBP pseudouridine synthase FOC14_22065 ENOG4105K4I Scp-like extracellular FOC14_22070 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC14_22075 ENOG4105CQB FAD linked oxidase domain protein FOC14_22090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_22095 ENOG4105BZU Histidine kinase FOC14_22100 ENOG4105JXH GntR family transcriptional regulator FOC14_22120 ENOG4106A3R peptidase FOC14_22130 ENOG4108QTI )-transporter FOC14_22135 ENOG4107TS3 membrane protein, TerC FOC14_22140 ENOG4105CZN Potassium uptake protein FOC14_22145 ENOG410681C small acid-soluble spore protein FOC14_22150 ENOG4108Z7G MaoC domain protein dehydratase FOC14_22170 ENOG4105CHR reductase FOC14_22180 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC14_22195 ENOG4105C4Y ABC transporter FOC14_22210 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC14_22225 ENOG4105E98 transcriptional regulator DeoR family FOC14_22245 ENOG4105PXI polysaccharide deacetylase FOC14_22255 ENOG4105BZU Histidine kinase FOC14_22260 ENOG41090MY MarR family Transcriptional regulator FOC14_22270 ENOG4106DF1 FOC14_22275 ENOG4105BZU Histidine kinase FOC14_22285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC14_22290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC14_22325 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC14_22345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC14_22350 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC14_22355 ENOG4105CZV ABC transporter FOC14_22365 ENOG4105CJ1 ABC, transporter FOC14_22405 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC14_22410 ENOG4105EA8 2-Nitropropane dioxygenase FOC14_22415 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC14_22425 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC14_22445 ENOG4105NQC Flavodoxin FOC14_22470 ENOG4107QMU Mate efflux family protein FOC14_22475 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC14_22505 ENOG4105CZN Potassium uptake protein FOC14_22510 ENOG41063Y9 FOC14_22515 ENOG4105KBJ sporulation protein ytfj FOC14_22540 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC14_22545 ENOG4105C7K acetolactate synthase FOC14_22550 ENOG4108ZP8 Acetolactate synthase small subunit FOC14_22555 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC14_22565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC14_22590 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC14_22625 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC14_22640 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC14_22645 ENOG4105E0M Sulfatase FOC14_22655 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC14_22675 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC14_22680 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC14_22690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC14_22695 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC14_22700 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC14_22705 ENOG4105C8J )-transporter FOC14_22725 ENOG4105DFD Na H antiporter FOC14_22745 ENOG4105ENE Histidine kinase FOC14_22750 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_22770 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC14_22795 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC14_22815 ENOG4105CJ3 phosphate transporter FOC14_22820 ENOG4107GRR phosphate transport regulator FOC14_22825 ENOG4105BZ4 penicillin-binding protein FOC14_22845 ENOG4105I3N Conserved Protein FOC14_22860 ENOG4105BZU Histidine kinase FOC14_22895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC14_22900 ENOG4105DZ1 carboxypeptidase FOC14_22905 ENOG4108JIC nucleoside recognition domain protein FOC14_22915 ENOG4105FE9 pseudouridine synthase FOC14_22925 ENOG4107TWT Cytochrome c biogenesis protein FOC14_22930 ENOG4105CRE cytochrome C FOC14_22935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_22940 ENOG4105BZU Histidine kinase FOC14_22945 ENOG4108WBT adenosyltransferase FOC14_22960 ENOG4108SAX Membrane FOC14_22970 ENOG4105T7X FOC14_22975 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC14_22980 ENOG4105I7S Abortive infection protein FOC14_22995 ENOG4107X2D transcriptional regulator, merr family FOC14_23000 ENOG4108S6Z Negative regulator of genetic competence FOC14_23025 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC14_23030 ENOG4105HDK L-asparaginase FOC14_23065 ENOG4105S2F FOC14_23070 ENOG41065D1 FOC14_23100 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC14_23115 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC14_23125 ENOG4105EAH synthase FOC14_23145 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC14_23150 ENOG41068YB TPR repeat-containing protein FOC14_23165 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC14_23170 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC14_23175 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC14_23205 ENOG4108JYZ YitT family FOC14_23210 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC14_23225 ENOG4105FJR Lmbe family FOC14_23230 ENOG4105CPK Glycosyl transferase (Group 1 FOC14_23265 ENOG4105DVT helicase FOC14_23270 ENOG4105YAC FOC14_23290 ENOG4105CSM endonuclease III FOC14_23300 ENOG4105BZ4 penicillin-binding protein FOC14_23355 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC14_23365 ENOG4105DVT helicase FOC14_23370 ENOG4105CTD carboxy-peptidase FOC14_23385 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC14_23400 ENOG4105C2W permease FOC14_23405 ENOG4105DHF Membrane FOC14_23415 ENOG410890F Dynamin family FOC14_23425 ENOG4108W0I acetyltransferase FOC14_23435 ENOG4105KHC sulfurtransferase FOC14_23535 ENOG4108SZE gCN5-related N-acetyltransferase FOC14_23555 ENOG41081VK Ribonuclease FOC14_23620 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_23630 ENOG4107RWR Sodium hydrogen exchanger FOC14_23640 ENOG4108Z5V transcriptional regulator, merr family FOC14_23650 ENOG4105H67 Protein of unknown function (DUF421) FOC14_23655 ENOG41080C8 DUF218 domain FOC14_23710 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC14_23720 ENOG4107R0U MotA TolQ exbB proton channel FOC14_23725 ENOG4105ER2 Ompa motb domain protein FOC14_23730 ENOG4107YTP response regulator receiver protein FOC14_23740 ENOG4105DD5 Flagellar motor switch protein FOC14_23755 ENOG4105BZU Histidine kinase FOC14_23775 ENOG4105E1Q flagellar hook-associated protein FOC14_23800 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC14_23805 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC14_23810 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOC14_23820 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC14_23855 ENOG4105BZE flagellar hook protein, FlgE FOC14_23880 ENOG4105K64 Glycosyl transferase, family 2 FOC14_23920 ENOG4105I03 Flagellin FOC14_23925 ENOG4105E4C Lytic transglycosylase catalytic FOC14_23940 ENOG4105DD5 Flagellar motor switch protein FOC14_23950 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC14_23955 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC14_23965 ENOG4105D00 flagellar biosynthetic protein flhB FOC14_23970 ENOG4105D7B Flagellar biosynthesis protein flha FOC14_23980 ENOG4105KTQ flagellar basal-body rod protein FOC14_23985 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC14_24010 ENOG4108RZE Tetr family transcriptional regulator FOC14_24030 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC14_24055 ENOG4105DUM transcriptional regulator, lysR family FOC14_24060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC14_24065 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC14_24070 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC14_24075 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC14_24115 ENOG4105CVJ phosphoglycerate mutase FOC14_24145 ENOG4105CAQ asparagine synthetase FOC14_24165 ENOG4105PGM cation diffusion facilitator family transporter FOC14_24175 ENOG4105DRR Transcriptional regulator, GntR family FOC14_24180 ENOG4108UZ3 Transporter FOC14_24185 ENOG4105CKI cobalamin synthesis protein FOC14_24190 ENOG4108PJD permease FOC14_24205 ENOG4105DFD Na H antiporter FOC14_24210 ENOG4105C9Q fumarate hydratase class II FOC14_24235 ENOG4105EC3 peptidase S51, dipeptidase E FOC14_24255 ENOG4107QIV Cytochrome c biogenesis protein FOC14_24285 ENOG4106BRA Membrane FOC14_24320 ENOG4105CJ1 ABC, transporter FOC14_24340 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC14_24350 ENOG4108IJ0 Aspartate ammonia-lyase FOC14_24355 ENOG4105C6K Malic enzyme FOC14_24415 ENOG4105FVX FOC14_24455 ENOG4105CSR polyphosphate kinase 2 FOC14_24485 ENOG4105EU0 Major facilitator Superfamily FOC14_24490 ENOG4105C6T cysteine synthase FOC14_24510 ENOG4105C8J )-transporter FOC14_24520 ENOG4105X5K response regulator receiver protein FOC14_24525 ENOG4105H67 Protein of unknown function (DUF421) FOC14_24540 ENOG4106KE4 Dehydrogenase FOC14_24555 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC14_24560 ENOG4105CHR reductase FOC14_24565 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC14_24570 ENOG4105C7K acetolactate synthase FOC14_24575 ENOG4108ZP8 Acetolactate synthase small subunit FOC14_24580 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC14_24590 ENOG4105C7B Threonine dehydratase FOC14_24615 ENOG4105C6X Major Facilitator FOC14_24620 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC14_24630 ENOG4105DY9 regulatoR FOC14_24635 ENOG4105CYC Transferase FOC14_24655 ENOG4105F6J Alpha beta hydrolase fold FOC14_24690 ENOG41068WN FOC14_24710 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC14_24715 ENOG4105C72 UPF0176 protein FOC14_24725 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC14_24755 ENOG4107RHR regulatoR FOC14_24765 ENOG4105D9N nucleoside FOC14_24770 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC14_24805 ENOG4107RAQ aminopeptidase FOC14_24810 ENOG4107STQ Multicopper oxidase FOC14_24855 ENOG4108T5E Copper resistance protein FOC14_24860 ENOG4105KTB nuclear export factor GLE1 FOC14_24870 ENOG4107RT3 EamA-like transporter family FOC14_24875 ENOG4105GZI Transcriptional regulator FOC14_24880 ENOG4108Z40 Transcriptional regulator FOC14_24885 ENOG4107ZXU DSBA oxidoreductase FOC14_24890 ENOG4108TVJ Nitroreductase FOC14_24895 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC14_24900 ENOG4106F5Q Membrane FOC14_24905 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC14_24915 ENOG4105CKI cobalamin synthesis protein FOC14_24935 ENOG4108Z7G MaoC domain protein dehydratase FOC14_24940 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC14_24950 ENOG4105C0Z ABC transporter FOC14_24955 ENOG4108IV0 ABC, transporter FOC14_24960 ENOG4105C32 Amino acid ABC transporter (Permease) FOC14_24970 ENOG4105SKE transcriptional Regulator LysR family FOC14_24980 ENOG4105MDS 4-oxalocrotonate tautomerase FOC14_24990 ENOG4105YGB Transcriptional regulator FOC14_25000 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC14_25005 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC14_25010 ENOG4108JJ9 ABC, transporter FOC14_25015 ENOG4108JJ8 (ABC) transporter FOC14_25065 ENOG4105EFI regulatoR FOC14_25070 ENOG4105BZU Histidine kinase FOC14_25090 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC14_25095 ENOG4108ZJ4 polysaccharide deacetylase FOC14_25115 ENOG4105D6E homoserine dehydrogenase FOC14_25140 ENOG4108KGH TRANSCRIPTIONal FOC14_25150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC14_25155 ENOG4105BZU Histidine kinase FOC14_25160 ENOG4107VMI polysaccharide deacetylase FOC14_25170 ENOG4105KT7 mgtC SapB transporter FOC14_25175 ENOG4105VRR gCN5-related N-acetyltransferase FOC14_25185 ENOG4105DUU IucA IucC family protein FOC14_25190 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_25205 ENOG4108WBH protein TIM barrel FOC14_25210 ENOG4105YWU small acid-soluble spore protein FOC14_25220 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC14_25270 ENOG4105KRN Transcriptional regulator, abrb family FOC14_25280 ENOG4105YVS arsR family transcriptional regulator FOC14_25285 ENOG4107SET aldo keto reductase FOC14_25290 ENOG4107XZQ multidrug resistance protein FOC14_25315 ENOG4105C8Q Methyl-accepting chemotaxis FOC14_25330 ENOG4108K88 Membrane FOC14_25335 ENOG4108WPJ Ferritin-like domain FOC14_25350 ENOG4105DEN Luciferase family FOC14_25370 ENOG4107QM2 Aldo Keto reductase FOC14_25375 ENOG4105CKI cobalamin synthesis protein FOC14_25430 ENOG4105DSE periplasmic solute binding protein FOC14_25435 ENOG4105K4T epimerase FOC14_25445 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC14_25470 ENOG4105CVJ phosphoglycerate mutase FOC14_25490 ENOG4107T5V SNARE associated Golgi FOC14_25505 ENOG4108PJD permease FOC14_25515 ENOG4108S4H thioesterase Superfamily protein FOC14_25525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC14_25545 ENOG4105SXS Protein of unknown function (DUF456) FOC14_25550 ENOG4105C37 (CBS) domain FOC14_25570 ENOG4108Z7R Chaperone CsaA FOC14_25590 ENOG4108ZRV stage ii sporulation protein p FOC14_25600 ENOG4108VXD carboxy-peptidase FOC14_25610 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC14_25635 ENOG4108X4Q Hydrolase FOC14_25645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC14_25650 ENOG4107RBS Methyltransferase FOC14_25665 ENOG41087PP glycosyltransferase MGT family FOC14_25670 ENOG4108JYZ YitT family FOC14_25675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC14_25700 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC14_25750 ENOG4105KBJ sporulation protein ytfj FOC14_25775 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC14_25800 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC14_25810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC14_25815 ENOG4105EMN RNA polymerase sigma factor FOC14_25840 ENOG4108V06 Glutathione peroxidase FOC14_25855 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC14_25875 ENOG4108IUE nitrate reductase beta subunit FOC14_25880 ENOG4105R3A Nitrate reductase FOC14_25905 ENOG4107V6Q Cyclic nucleotide-binding domain FOC14_25910 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC14_25915 ENOG4105D06 uba thif-type nad fad binding protein FOC14_25920 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC14_25925 ENOG4108ZAF Molybdopterin FOC14_25950 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC14_25955 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC14_25960 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC14_25965 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC14_25970 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC14_25975 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC14_26010 ENOG4105MCT stage V sporulation protein S FOC14_26025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC14_26045 ENOG4105C5H ABC transporter FOC14_26060 ENOG4108UUM single-stranded DNA-binding protein FOC14_26090 ENOG4107YX5 Pfam:DUF548 FOC14_26095 ENOG4105C75 arginyL-tRNA synthetase FOC14_26120 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC14_26140 ENOG4105C5S asparaginyl-tRNA synthetase FOC14_26160 ENOG4105EC2 ftsk spoIIIe FOC14_26230 ENOG4105BZW Glycerate kinase FOC14_26235 ENOG4107QPK )-transporter FOC14_26240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC14_26245 ENOG41062D9 Histidine kinase FOC14_26260 ENOG4105C8J )-transporter FOC14_26280 ENOG4107XGZ Hydrolase FOC14_26285 ENOG4105CY2 Citrate transporter FOC14_26290 ENOG4105C0A alcohol dehydrogenase FOC14_26305 ENOG4105KD7 acetyltransferase FOC14_26335 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC14_26355 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC14_26370 ENOG4107RVG penicillin-binding protein FOC14_26375 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC14_26380 ENOG4105E9Q Acyl-transferase FOC14_26385 ENOG4108UT2 hemolysin iii FOC14_26395 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC14_26405 ENOG4108RCR degv family FOC14_26410 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC14_26415 ENOG4108KF3 Electron transport protein SCO1 SenC FOC14_26420 ENOG4107Y70 Heat shock protein FOC14_26425 ENOG4105CAQ asparagine synthetase FOC14_26440 ENOG4108MES Periplasmic binding protein FOC14_26445 ENOG4105F0I Aminotransferase FOC14_26480 ENOG4105D8X mechanosensitive ion channel FOC14_26485 ENOG4105BZU Histidine kinase FOC14_26490 ENOG4105WH1 Two component transcriptional regulator luxr family FOC14_26525 ENOG4105CMG Carbohydrate kinase FOC14_26530 ENOG4105CMG Carbohydrate kinase FOC14_26560 ENOG4108IJ8 ABC transporter FOC14_26565 ENOG4105E90 ABC transporter FOC14_26600 ENOG4105C37 (CBS) domain FOC14_26625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC14_26640 ENOG4107S4Y M20 DapE family protein YgeY FOC14_26645 ENOG4108TSC N-acetyltransferase FOC14_26650 ENOG4108JUB Transcriptional regulator FOC14_26655 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC14_26695 ENOG4108N23 SpoOM-related protein FOC14_26700 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC14_26710 ENOG4105SZ6 Thioredoxin FOC14_26725 ENOG4108IBT Inherit from COG: transposase FOC14_26830 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC14_26870 ENOG4105BZ4 penicillin-binding protein FOC14_26875 ENOG4105CZM Major Facilitator FOC14_26880 ENOG4105W8X HesB YadR YfhF-family protein FOC14_26890 ENOG4105DXD 2-methylcitrate dehydratase FOC14_26895 ENOG4105CR4 methylisocitrate lyase FOC14_26900 ENOG4105C1G acyl-Coa dehydrogenase FOC14_26905 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC14_26915 ENOG4105N14 lysine exporter protein LysE YggA FOC14_26920 ENOG4105E39 Enoyl-CoA hydratase FOC14_26935 ENOG4107RFY SbcCD D subunit FOC14_26940 ENOG4105EYH Exonuclease FOC14_26960 ENOG4105FCD Major Facilitator FOC14_26965 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC14_26970 ENOG4105E4F Isochorismate synthase FOC14_26975 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC14_26980 ENOG4105WQI isochorismatase FOC14_26985 ENOG4105CEY Amp-dependent synthetase and ligase FOC14_26990 ENOG4105WQT MbtH domain protein FOC14_26995 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC14_27010 ENOG4105K70 DNA-binding protein FOC14_27030 ENOG4105BZG amino acid carrier protein FOC14_27050 ENOG4105FE9 pseudouridine synthase FOC14_27055 ENOG4105C22 threonyL-tRNA synthetase FOC14_27070 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC14_27095 ENOG4108D32 Methyltransferase FOC14_27125 ENOG41081I9 integral membrane protein