locus-tag class description HYU01_00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HYU01_00020 ENOG410848D S4 domain protein YaaA HYU01_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYU01_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYU01_00105 ENOG4105ZMH deoxynucleoside kinase HYU01_00115 ENOG4105GTG Isochorismatase HYU01_00120 ENOG4108Z6B deaminase HYU01_00125 ENOG4105C6E dna polymerase iii HYU01_00145 ENOG41067KS pro-sigma K processing HYU01_00180 ENOG4105CXN decarboxylase HYU01_00190 ENOG4105FA2 dna polymerase iii HYU01_00195 ENOG4105MA4 psp1 domain protein HYU01_00205 ENOG41060K3 Methyltransferase HYU01_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HYU01_00220 ENOG4105KRN Transcriptional regulator, abrb family HYU01_00230 ENOG4105F8V Hydrolase, tatD family HYU01_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HYU01_00245 ENOG4105XFA sporulation peptidase YabG HYU01_00250 ENOG4105W42 Veg protein HYU01_00265 ENOG4105DFT pur operon repressor HYU01_00270 ENOG4105KME endoribonuclease L-psp HYU01_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HYU01_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HYU01_00300 ENOG4108JA2 transcriptioN-repair coupling factor HYU01_00305 ENOG4108M14 stage v sporulation protein t HYU01_00315 ENOG4108IY2 MazG family HYU01_00320 ENOG41082I2 s4 domain protein HYU01_00325 ENOG4105VYY sporulation protein yabp HYU01_00340 ENOG41060GV RNA binding s1 domain protein HYU01_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HYU01_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase HYU01_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HYU01_00385 ENOG4105C6T cysteine synthase HYU01_00390 ENOG4105CRQ synthase (Component I) HYU01_00395 ENOG4105DDQ anthranilate synthase HYU01_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HYU01_00405 ENOG4105EEI dihydropteroate synthase HYU01_00410 ENOG4105KRF dihydroneopterin aldolase HYU01_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HYU01_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HYU01_00455 ENOG4108Z0C Uvrb UvrC protein HYU01_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HYU01_00480 ENOG4105CTP PilT protein domain protein HYU01_00500 ENOG4105D7W serine acetyltransferase HYU01_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 HYU01_00520 ENOG4105M0M Tetracycline resistance protein HYU01_00525 ENOG4105QIV RNA polymerase HYU01_00535 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HYU01_00560 ENOG4107Y49 methyltransferase HYU01_00570 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HYU01_00575 ENOG4105XPM ribosomal protein HYU01_00680 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HYU01_00705 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HYU01_00715 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HYU01_00725 ENOG41067V7 50S ribosomal protein L36 HYU01_00755 ENOG4108JJB ABC transporter HYU01_00760 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HYU01_00765 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HYU01_00790 ENOG4105D1F ATP-binding protein HYU01_00805 ENOG4108NMV polysaccharide deacetylase HYU01_00890 ENOG4105C8B TIGR00159 family HYU01_00895 ENOG4107U5W ybbr family HYU01_00910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYU01_00915 ENOG4108VQT Alpha beta hydrolase fold protein HYU01_00925 ENOG4105CMG Carbohydrate kinase HYU01_00935 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HYU01_00940 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HYU01_00975 ENOG4108PSK reductase HYU01_00980 ENOG4108UMI ABC transporter, permease HYU01_00985 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYU01_00990 ENOG4105D01 (LipO)protein HYU01_00995 ENOG4105EE1 crotonyl-CoA reductase HYU01_01020 ENOG4105C2C drug resistance transporter, Bcr CflA HYU01_01035 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYU01_01040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYU01_01045 ENOG4105C3U ABC transporter HYU01_01050 ENOG4108JQ7 (ABC) transporter HYU01_01080 ENOG4108J59 Extracellular solute-binding protein, family 5 HYU01_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 HYU01_01095 ENOG4105II7 pyrroline-5-carboxylate reductase HYU01_01105 ENOG4107XDY Nicotinamide Mononucleotide Transporter HYU01_01115 ENOG4105E0C molybdate abc transporter HYU01_01120 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HYU01_01125 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HYU01_01140 ENOG4105EGI Transcriptional regulator HYU01_01160 ENOG4105F6E Acyl-transferase HYU01_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HYU01_01200 ENOG4108RE7 deoxyribonuclease HYU01_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HYU01_01230 ENOG4105C5H ABC transporter HYU01_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HYU01_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYU01_01260 ENOG4105C3U ABC transporter HYU01_01265 ENOG4108JQ7 (ABC) transporter HYU01_01285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HYU01_01290 ENOG4105ERH Fumarylacetoacetate hydrolase HYU01_01300 ENOG4108SC4 )-transporter HYU01_01310 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HYU01_01325 ENOG4107ZXI Rhomboid family HYU01_01335 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HYU01_01340 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HYU01_01355 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HYU01_01455 ENOG4105K8N protein family UPF0079, ATPase HYU01_01460 ENOG41072GX Peptidase M22 Glycoprotease HYU01_01465 ENOG410801F ribosomal-protein-alanine acetyltransferase HYU01_01470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HYU01_01475 ENOG4105C5H ABC transporter HYU01_01490 ENOG4108TYN CAAX amino terminal protease family protein HYU01_01510 ENOG4105C7N Xanthine uracil vitamin C permease HYU01_01520 ENOG4105BZU Histidine kinase HYU01_01540 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HYU01_01560 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_01580 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HYU01_01585 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HYU01_01590 ENOG4105C83 adenylosuccinate lyase HYU01_01600 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HYU01_01625 ENOG4108V3E phosphoribosylglycinamide formyltransferase HYU01_01635 ENOG4105C12 Phosphoribosylglycinamide synthetase HYU01_01660 ENOG4105C4R Atp-dependent dna helicase HYU01_01690 ENOG4108W2Y isochorismatase HYU01_01695 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYU01_01700 ENOG4108UMI ABC transporter, permease HYU01_01705 ENOG4105D01 (LipO)protein HYU01_01720 ENOG410834F Transcriptional regulator HYU01_01745 ENOG4105CBD Diacylglycerol kinase HYU01_01750 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HYU01_01755 ENOG4108JPW Aminotransferase HYU01_01765 ENOG4105C26 Dehydrogenase HYU01_01770 ENOG4105KPY Small multidrug resistance protein HYU01_01790 ENOG4105D9N nucleoside HYU01_01795 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HYU01_01810 ENOG4108W15 Protein of unknown function (DUF1456) HYU01_01825 ENOG4105DTQ mandelate racemase muconate lactonizing HYU01_01835 ENOG4105DFD Na H antiporter HYU01_01855 ENOG4105D3R alkyl hydroperoxide reductase HYU01_01860 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HYU01_01870 ENOG4107W7X Aldolase HYU01_01875 ENOG4105EHG Permease protein HYU01_01880 ENOG4105DQ5 transport system permease protein HYU01_01885 ENOG4108V5C ABC transporter HYU01_01905 ENOG4106UIA HYU01_01910 ENOG4106UIA HYU01_01940 ENOG4105BZU Histidine kinase HYU01_01960 ENOG410756H nucleotidyltransferase HYU01_01965 ENOG4105D2S major facilitator superfamily HYU01_01980 ENOG4105E5Q amino acid AbC transporter HYU01_01985 ENOG4105EAB amino acid AbC transporter HYU01_02005 ENOG4105C8Q Methyl-accepting chemotaxis HYU01_02015 ENOG4105CI1 PTS System HYU01_02045 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HYU01_02060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HYU01_02075 ENOG4105C5H ABC transporter HYU01_02100 ENOG41062JF Transcriptional regulator HYU01_02120 ENOG4105DEU major facilitator superfamily HYU01_02135 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HYU01_02150 ENOG4108N0M stress protein HYU01_02155 ENOG4106FN3 tellurium resistance protein HYU01_02160 ENOG4106FN3 tellurium resistance protein HYU01_02165 ENOG4107TS3 membrane protein, TerC HYU01_02170 ENOG4108TTB tellurium resistance protein HYU01_02190 ENOG4105KJF protein tyrosine phosphatase HYU01_02200 ENOG4107U9T Pfam:Ribonuclease_BN HYU01_02210 ENOG4105C59 p-type ATPase HYU01_02215 ENOG4108IPJ Membrane HYU01_02235 ENOG4107ZTW SNARE associated Golgi HYU01_02250 ENOG410606W general stress protein HYU01_02255 ENOG4105UPD Calcium Proton HYU01_02295 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HYU01_02300 ENOG4105VTR Integrase HYU01_02315 ENOG4108IMY Transcriptional regulator HYU01_02610 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HYU01_02620 ENOG4108JUB Transcriptional regulator HYU01_02630 ENOG4108IQI permease HYU01_02660 ENOG4105CSV Glutaminase HYU01_02670 ENOG4108A04 Beta-lactamase HYU01_02685 ENOG4105CKK Glycosyl transferase, family 2 HYU01_02695 ENOG4107QQG Dehydrogenase HYU01_02700 ENOG4105C3I Nad-dependent epimerase dehydratase HYU01_02715 ENOG4105F1A Pyruvate formate-lyase HYU01_02735 ENOG4105CI2 imidazolone-5-propionate hydrolase HYU01_02740 ENOG4105ECP epimerase HYU01_02770 ENOG41067AE Membrane-bound metal-dependent hydrolase HYU01_02775 ENOG4105CEN a g-specific adenine glycosylase HYU01_02780 ENOG4106BXE HYU01_02800 ENOG4105BZ1 (ABC) transporter HYU01_02805 ENOG4107NBY Membrane HYU01_02810 ENOG4105CBC glutamate synthase HYU01_02820 ENOG4108IUW ABC transporter HYU01_02840 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HYU01_02845 ENOG4105G5W regulator Fur family HYU01_02960 ENOG4108JQC penicillin-binding protein 1A HYU01_02965 ENOG4107ZQN disulfide bond HYU01_02975 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HYU01_02985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HYU01_02990 ENOG4105BZU Histidine kinase HYU01_03000 ENOG4105CYN Serine protein kinase HYU01_03020 ENOG4105C94 Transporter HYU01_03035 ENOG4105DZ6 Band 7 protein HYU01_03045 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HYU01_03050 ENOG4108MRH transcriptional regulatory protein HYU01_03055 ENOG4105D4T Citrate transporter HYU01_03075 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HYU01_03080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYU01_03085 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HYU01_03090 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HYU01_03095 ENOG4105BZ7 extracellular solute-binding protein family 1 HYU01_03105 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HYU01_03110 ENOG4108STX response regulator HYU01_03115 ENOG4105US7 Histidine kinase HYU01_03140 ENOG4108MRH transcriptional regulatory protein HYU01_03150 ENOG4105C6K Malic enzyme HYU01_03165 ENOG4108UZ3 Transporter HYU01_03170 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYU01_03180 ENOG4105BZU Histidine kinase HYU01_03185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_03200 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HYU01_03205 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HYU01_03210 ENOG4108JB9 formate dehydrogenase HYU01_03235 ENOG4105CUB amino acid HYU01_03245 ENOG4105C59 p-type ATPase HYU01_03250 ENOG4105DAP Nicotinate phosphoribosyltransferase HYU01_03285 ENOG41073R8 VanW family HYU01_03290 ENOG4108KGH TRANSCRIPTIONal HYU01_03295 ENOG4105D9N nucleoside HYU01_03300 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HYU01_03305 ENOG4105C37 (CBS) domain HYU01_03310 ENOG4108IJ0 Aspartate ammonia-lyase HYU01_03315 ENOG4105DAA L-lactate HYU01_03330 ENOG4105DUX Transporter HYU01_03335 ENOG4108MES Periplasmic binding protein HYU01_03340 ENOG4105DQ5 transport system permease protein HYU01_03345 ENOG4108IHU transport system permease protein HYU01_03350 ENOG4105E0A ABC, transporter HYU01_03355 ENOG4105DMQ Methyltransferase HYU01_03365 ENOG4105EXW epimerase dehydratase HYU01_03375 ENOG4107T89 von Willebrand factor, type A HYU01_03380 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HYU01_03385 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HYU01_03400 ENOG4105BZU Histidine kinase HYU01_03405 ENOG4105D5Q Arginine ornithine antiporter HYU01_03410 ENOG4107414 GntR family transcriptional regulator HYU01_03415 ENOG4105C5Y PTS System HYU01_03420 ENOG4105CG3 alpha amylase, catalytic region HYU01_03435 ENOG4105E1K spore germination protein HYU01_03445 ENOG4105CRN Aminoglycoside phosphotransferase HYU01_03450 ENOG4105BZG amino acid carrier protein HYU01_03455 ENOG4105CDA abc transporter atp-binding protein HYU01_03460 ENOG4105CT1 (ABC) transporter HYU01_03465 ENOG4105EAD ABC transporter HYU01_03470 ENOG4105DRP amino acid AbC transporter HYU01_03475 ENOG4108IQI permease HYU01_03500 ENOG4105D29 Helix-turn-helix type 11 domain protein HYU01_03505 ENOG4105NAE bifunctional deaminase-reductase domain protein HYU01_03510 ENOG4105BZU Histidine kinase HYU01_03525 ENOG4105CHH sulfate transporter HYU01_03530 ENOG41068KF Universal stress protein HYU01_03540 ENOG4105DEF Extracellular solute-binding protein, family 5 HYU01_03550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYU01_03555 ENOG4108JQ7 (ABC) transporter HYU01_03565 ENOG4105CXY transporter HYU01_03570 ENOG41067TZ transcriptional regulator, MarR family HYU01_03575 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_03580 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_03585 ENOG4105ETE Transcriptional regulator (LacI family HYU01_03590 ENOG4108RVA ribokinase HYU01_03600 ENOG4105C2J ABC transporter HYU01_03605 ENOG4105CNN ABC, transporter HYU01_03610 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HYU01_03615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HYU01_03675 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HYU01_03680 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HYU01_03685 ENOG41069ER domain protein HYU01_03690 ENOG4105VZ8 Transcriptional regulator HYU01_03695 ENOG4107D63 HYU01_03705 ENOG4105DUX Transporter HYU01_03725 ENOG4105C85 amino acid HYU01_03730 ENOG4105C7N Xanthine uracil vitamin C permease HYU01_03770 ENOG4105BZ9 Cytochrome C oxidase, subunit I HYU01_03775 ENOG4105E2S oxidase) subunit II HYU01_03790 ENOG4106CAD Protein of unknown function (DUF3311) HYU01_03795 ENOG4105E1V na solute symporter HYU01_03810 ENOG4108NHD germination protein HYU01_03820 ENOG4105CE1 Ferrous iron transport protein b HYU01_03825 ENOG4105CE1 Ferrous iron transport protein b HYU01_03830 ENOG4105CE1 Ferrous iron transport protein b HYU01_03835 ENOG4105CVA phosphate HYU01_03840 ENOG4105C8U phosphate abc transporter HYU01_03845 ENOG4105E2Z phosphate ABC transporter (Permease HYU01_03895 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HYU01_03975 ENOG41080XQ Signal transduction protein with cbs domains HYU01_03995 ENOG4105ETU transcriptional activator (TenA HYU01_04005 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HYU01_04015 ENOG4108VEU Thiamine monophosphate synthase HYU01_04020 ENOG41080HI glycine oxidase HYU01_04035 ENOG4105D06 uba thif-type nad fad binding protein HYU01_04040 ENOG4105DWF phosphomethylpyrimidine kinase HYU01_04095 ENOG4108INS Transcriptional regulator HYU01_04110 ENOG4105C7N Xanthine uracil vitamin C permease HYU01_04120 ENOG4108PXI ErfK YbiS YcfS YnhG HYU01_04140 ENOG4105C5Y PTS System HYU01_04195 ENOG4107Y03 Nitroreductase HYU01_04200 ENOG4105ED1 spovr family HYU01_04230 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HYU01_04235 ENOG4105XTG Pfam:DUF156 HYU01_04240 ENOG4105VFE sira family HYU01_04245 ENOG4107TPS domain protein HYU01_04250 ENOG4105VFE sira family HYU01_04255 ENOG41085GJ domain protein HYU01_04265 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HYU01_04270 ENOG41087NI Sulfite exporter TauE/SafE HYU01_04280 ENOG4108KGH TRANSCRIPTIONal HYU01_04305 ENOG4105EMD TRANSCRIPTIONal HYU01_04310 ENOG4105VCP PTS System HYU01_04315 ENOG4105VZJ PTS System HYU01_04335 ENOG41069ER domain protein HYU01_04340 ENOG4107RBB ABC transporter, permease HYU01_04345 ENOG4105C19 ABC transporter HYU01_04375 ENOG4105WEF catalase HYU01_04410 ENOG4107T5V SNARE associated Golgi HYU01_04445 ENOG4105CUB amino acid HYU01_04455 ENOG4107RWR Sodium hydrogen exchanger HYU01_04465 ENOG4106KNT transcriptional regulator HYU01_04500 ENOG4108PCN EamA-like transporter family HYU01_04505 ENOG4108YXU transcriptional regulator AsnC family HYU01_04515 ENOG4105KPY Small multidrug resistance protein HYU01_04520 ENOG4105KPY Small multidrug resistance protein HYU01_04545 ENOG4105NF4 modulator of drug activity HYU01_04550 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HYU01_04555 ENOG4105E5W Transporter HYU01_04565 ENOG4107RKG DJ-1/PfpI family HYU01_04570 ENOG4105CH6 catalase HYU01_04580 ENOG4105D5Q Arginine ornithine antiporter HYU01_04585 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HYU01_04595 ENOG4105C26 Dehydrogenase HYU01_04605 ENOG4105BZ1 (ABC) transporter HYU01_04625 ENOG4105DRP amino acid AbC transporter HYU01_04630 ENOG4105CDA abc transporter atp-binding protein HYU01_04645 ENOG410839P HYU01_04680 ENOG4107FQX Alpha-acetolactate decarboxylase HYU01_04710 ENOG4105D4P Coproporphyrinogen iii oxidase HYU01_04725 ENOG4105CHH sulfate transporter HYU01_04765 ENOG4106AKK s-layer domain-containing protein HYU01_04775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HYU01_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HYU01_04795 ENOG4105CGU Enoyl-CoA hydratase HYU01_04815 ENOG4105DER m42 family HYU01_04835 ENOG4105CTU Proline racemase HYU01_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYU01_04890 ENOG4108JQ7 (ABC) transporter HYU01_04925 ENOG4105CSH Transporter HYU01_04935 ENOG4108MRH transcriptional regulatory protein HYU01_04985 ENOG4105CDU Replicative dna helicase HYU01_05030 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_05085 ENOG4108IG5 Transcriptional regulator HYU01_05105 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HYU01_05125 ENOG4105CMT Dihydroxyacetone kinase HYU01_05135 ENOG4105CMT Dihydroxyacetone kinase HYU01_05140 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HYU01_05145 ENOG410847I Transcriptional regulator, BadM Rrf2 family HYU01_05170 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HYU01_05240 ENOG4105WN5 stage II sporulation protein HYU01_05250 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_05260 ENOG4108MJI response regulator HYU01_05265 ENOG4105BZU Histidine kinase HYU01_05270 ENOG4105BZU Histidine kinase HYU01_05295 ENOG4105K8R UPF0145 protein HYU01_05335 ENOG4107VRP DNA repair exonuclease HYU01_05340 ENOG4106D4I domain protein HYU01_05350 ENOG4105D7V transposase HYU01_05365 ENOG4108IND Tetr family transcriptional regulator HYU01_05370 ENOG4105EQ0 Major Facilitator superfamily HYU01_05395 ENOG4108MUZ hydrolase HYU01_05415 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HYU01_05430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HYU01_05445 ENOG4105EMN RNA polymerase sigma factor HYU01_05470 ENOG4105C57 major facilitator superfamily HYU01_05475 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_05485 ENOG4105EEM helicase HYU01_05490 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HYU01_05520 ENOG4105K59 histidine triad (HIT) protein HYU01_05555 ENOG410905X membrane-flanked domain protein HYU01_05565 ENOG4105CKV Membrane HYU01_05605 ENOG410905X membrane-flanked domain protein HYU01_05610 ENOG4105CKV Membrane HYU01_05615 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HYU01_05620 ENOG4105BZ4 penicillin-binding protein HYU01_05625 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HYU01_05635 ENOG4105C1Q protoporphyrinogen oxidase HYU01_05660 ENOG4105NA0 Transcriptional regulator HYU01_05675 ENOG4105ECB domain protein HYU01_05710 ENOG4108RQ5 Beta-lactamase domain-containing protein HYU01_05715 ENOG4105DF9 Lipoate-protein, ligase HYU01_05725 ENOG4105CEY Amp-dependent synthetase and ligase HYU01_05755 ENOG4105CNA YD repeat protein HYU01_05775 ENOG4105ENX hydrolase HYU01_05785 ENOG4107RN3 metallophosphoesterase HYU01_05790 ENOG4107TVP HD domain protein HYU01_05800 ENOG4108AEY RNA polymerase sigma factor HYU01_05805 ENOG41086D8 Transcriptional regulator HYU01_05825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_05850 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HYU01_05855 ENOG4105C8Q Methyl-accepting chemotaxis HYU01_05875 ENOG4105ZU5 s-layer protein HYU01_05880 ENOG4107QP3 malate synthase g HYU01_05895 ENOG4105VEQ Cold shock protein HYU01_05910 ENOG4105XVF Competence transcription factor HYU01_05925 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HYU01_05930 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HYU01_05975 ENOG4105ERH Fumarylacetoacetate hydrolase HYU01_06000 ENOG4105CAQ asparagine synthetase HYU01_06005 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HYU01_06010 ENOG4105CH6 catalase HYU01_06015 ENOG4105BZU Histidine kinase HYU01_06035 ENOG4105QNR S1 RNA binding domain protein HYU01_06045 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HYU01_06055 ENOG4107AYK membrAne HYU01_06060 ENOG41073B9 HYU01_06070 ENOG4108KP7 hydrolase HYU01_06080 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYU01_06105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYU01_06110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HYU01_06125 ENOG4105C31 Tryptophanyl-tRNA synthetase HYU01_06140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HYU01_06145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYU01_06155 ENOG4108JQ7 (ABC) transporter HYU01_06160 ENOG4105UQX Mate efflux family protein HYU01_06180 ENOG4108ZCF integral membrane protein HYU01_06190 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HYU01_06200 ENOG4105DPN Oligoendopeptidase f HYU01_06215 ENOG4108Z18 K06886 hemoglobin HYU01_06220 ENOG4105MIX Adenylate cyclase HYU01_06235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HYU01_06240 ENOG4105EMS pseudouridine synthase HYU01_06260 ENOG4105K64 Glycosyl transferase, family 2 HYU01_06280 ENOG4107TVC Glycosyl transferase, family 2 HYU01_06300 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HYU01_06305 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HYU01_06315 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HYU01_06365 ENOG4108WVJ 2'-5' rna ligase HYU01_06390 ENOG4105CK7 Sodium proline symporter HYU01_06400 ENOG4105CRQ synthase (Component I) HYU01_06405 ENOG4105DDQ anthranilate synthase HYU01_06495 ENOG4105C7S Dehydrogenase HYU01_06505 ENOG4105VZ8 Transcriptional regulator HYU01_06560 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HYU01_06570 ENOG4105DZ1 carboxypeptidase HYU01_06575 ENOG4105VFR signal peptidase HYU01_06610 ENOG4105C26 Dehydrogenase HYU01_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYU01_06620 ENOG4105F38 ABC transporter, permease HYU01_06625 ENOG4105D38 putrescine abc transporter HYU01_06630 ENOG4107RUE extracellular solute-binding protein family 1 HYU01_06640 ENOG4105EYF MMPL domain protein HYU01_06650 ENOG4108YBP pseudouridine synthase HYU01_06660 ENOG4105K4I Scp-like extracellular HYU01_06665 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HYU01_06670 ENOG4105CQB FAD linked oxidase domain protein HYU01_06685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_06690 ENOG4105BZU Histidine kinase HYU01_06695 ENOG4105JXH GntR family transcriptional regulator HYU01_06715 ENOG4106A3R peptidase HYU01_06725 ENOG4108QTI )-transporter HYU01_06730 ENOG4107TS3 membrane protein, TerC HYU01_06740 ENOG410681C small acid-soluble spore protein HYU01_06745 ENOG4108Z7G MaoC domain protein dehydratase HYU01_06765 ENOG4105CHR reductase HYU01_06775 ENOG4105MWK D-amino acid dehydrogenase, small subunit HYU01_06795 ENOG4105C4Y ABC transporter HYU01_06815 ENOG4107RCV ABC transporter, permease HYU01_06820 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HYU01_06835 ENOG4105E98 transcriptional regulator DeoR family HYU01_06860 ENOG4105PXI polysaccharide deacetylase HYU01_06870 ENOG4105BZU Histidine kinase HYU01_06875 ENOG41090MY MarR family Transcriptional regulator HYU01_06885 ENOG4106DF1 HYU01_06895 ENOG4105BZU Histidine kinase HYU01_06905 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HYU01_06910 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HYU01_06950 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HYU01_06970 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYU01_06975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HYU01_06980 ENOG4105CZV ABC transporter HYU01_06990 ENOG4105CJ1 ABC, transporter HYU01_07030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HYU01_07035 ENOG4105EA8 2-Nitropropane dioxygenase HYU01_07040 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HYU01_07050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HYU01_07075 ENOG4105NQC Flavodoxin HYU01_07110 ENOG4107QMU Mate efflux family protein HYU01_07115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HYU01_07145 ENOG4105CZN Potassium uptake protein HYU01_07150 ENOG41063Y9 HYU01_07155 ENOG4105KBJ sporulation protein ytfj HYU01_07180 ENOG4105CM2 brancheD-chain amino acid aminotransferase HYU01_07185 ENOG4105C7K acetolactate synthase HYU01_07190 ENOG4108ZP8 Acetolactate synthase small subunit HYU01_07195 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HYU01_07205 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HYU01_07230 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HYU01_07265 ENOG4107RVV histidinol phosphate phosphatase, hisj family HYU01_07280 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HYU01_07285 ENOG4105E0M Sulfatase HYU01_07295 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HYU01_07315 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HYU01_07320 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HYU01_07330 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HYU01_07335 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HYU01_07340 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HYU01_07345 ENOG4105C8J )-transporter HYU01_07365 ENOG4105DFD Na H antiporter HYU01_07385 ENOG4105ENE Histidine kinase HYU01_07390 ENOG4105WH1 Two component transcriptional regulator luxr family HYU01_07410 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HYU01_07440 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HYU01_07460 ENOG4105CJ3 phosphate transporter HYU01_07465 ENOG4107GRR phosphate transport regulator HYU01_07490 ENOG4105BZU Histidine kinase HYU01_07495 ENOG4105I3N Conserved Protein HYU01_07515 ENOG4105BZU Histidine kinase HYU01_07550 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYU01_07555 ENOG4105DZ1 carboxypeptidase HYU01_07560 ENOG4108JIC nucleoside recognition domain protein HYU01_07570 ENOG4105FE9 pseudouridine synthase HYU01_07580 ENOG4107TWT Cytochrome c biogenesis protein HYU01_07585 ENOG4105CRE cytochrome C HYU01_07590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_07595 ENOG4105BZU Histidine kinase HYU01_07600 ENOG4108WBT adenosyltransferase HYU01_07615 ENOG4108SAX Membrane HYU01_07625 ENOG4105T7X HYU01_07630 ENOG4105C9U ATP-dependent DNA helicase RecQ HYU01_07635 ENOG4105I7S Abortive infection protein HYU01_07650 ENOG4107X2D transcriptional regulator, merr family HYU01_07655 ENOG4108S6Z Negative regulator of genetic competence HYU01_07680 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HYU01_07685 ENOG4107RB3 L-asparaginase HYU01_07720 ENOG4105S2F HYU01_07725 ENOG41065D1 HYU01_07755 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HYU01_07770 ENOG4105XXQ heptaprenyl diphosphate synthase component I HYU01_07780 ENOG4105EAH synthase HYU01_07800 ENOG4105CIH Imidazole acetol-phosphate transaminase HYU01_07805 ENOG41068YB TPR repeat-containing protein HYU01_07820 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HYU01_07825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HYU01_07830 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit HYU01_07860 ENOG4108JYZ YitT family HYU01_07865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HYU01_07880 ENOG4105FJR Lmbe family HYU01_07885 ENOG4105CPK Glycosyl transferase (Group 1 HYU01_07945 ENOG4105CSM endonuclease III HYU01_07955 ENOG4105BZ4 penicillin-binding protein HYU01_08010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HYU01_08020 ENOG4105DVT helicase HYU01_08025 ENOG4105CTD carboxy-peptidase HYU01_08040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HYU01_08050 ENOG4105C2W permease HYU01_08055 ENOG4105DHF Membrane HYU01_08065 ENOG410890F Dynamin family HYU01_08075 ENOG4108W0I acetyltransferase HYU01_08085 ENOG4105KHC sulfurtransferase HYU01_08100 ENOG4106032 Glutathionylspermidine synthase HYU01_08180 ENOG4108SZE gCN5-related N-acetyltransferase HYU01_08205 ENOG41081VK Ribonuclease HYU01_08270 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYU01_08280 ENOG4107RWR Sodium hydrogen exchanger HYU01_08285 ENOG4105CN5 Metallo-Beta-Lactamase HYU01_08290 ENOG4108Z5V transcriptional regulator, merr family HYU01_08300 ENOG4105H67 Protein of unknown function (DUF421) HYU01_08305 ENOG41080C8 DUF218 domain HYU01_08360 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HYU01_08370 ENOG4107R0U MotA TolQ exbB proton channel HYU01_08375 ENOG4105ER2 Ompa motb domain protein HYU01_08380 ENOG4107YTP response regulator receiver protein HYU01_08390 ENOG4105DD5 Flagellar motor switch protein HYU01_08405 ENOG4105BZU Histidine kinase HYU01_08425 ENOG4105E1Q flagellar hook-associated protein HYU01_08430 ENOG4105DTJ flagellar hook-associated protein HYU01_08455 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HYU01_08460 ENOG4108ZC9 flagellar basal-body rod protein flgc HYU01_08465 ENOG41075Z6 flagellar hook-basal body complex protein fliE HYU01_08470 ENOG4107U2N Flagellar M-ring protein HYU01_08480 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HYU01_08520 ENOG4105BZE flagellar hook protein, FlgE HYU01_08535 ENOG4107R88 Chemotaxis protein (CheV) HYU01_08545 ENOG4105K64 Glycosyl transferase, family 2 HYU01_08580 ENOG4107TVC Glycosyl transferase, family 2 HYU01_08605 ENOG4105I03 Flagellin HYU01_08610 ENOG4105E4C Lytic transglycosylase catalytic HYU01_08625 ENOG4105DD5 Flagellar motor switch protein HYU01_08635 ENOG4105CN7 Flagellar biosynthetic protein FliP HYU01_08640 ENOG4105VS8 Flagellar biosynthetic protein fliq HYU01_08650 ENOG4105D00 flagellar biosynthetic protein flhB HYU01_08655 ENOG4105D7B Flagellar biosynthesis protein flha HYU01_08660 ENOG4105FZW flagellar biosynthesis regulator FlhF HYU01_08665 ENOG4105KTQ flagellar basal-body rod protein HYU01_08670 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HYU01_08695 ENOG4108RZE Tetr family transcriptional regulator HYU01_08715 ENOG4105KAC Antibiotic biosynthesis monooxygenase HYU01_08745 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYU01_08750 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HYU01_08755 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HYU01_08760 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HYU01_08795 ENOG4105CVJ phosphoglycerate mutase HYU01_08825 ENOG4105CAQ asparagine synthetase HYU01_08845 ENOG4105PGM cation diffusion facilitator family transporter HYU01_08855 ENOG4105DRR Transcriptional regulator, GntR family HYU01_08860 ENOG4108UZ3 Transporter HYU01_08865 ENOG4105CKI cobalamin synthesis protein HYU01_08870 ENOG4108PJD permease HYU01_08885 ENOG4105DFD Na H antiporter HYU01_08890 ENOG4105C9Q fumarate hydratase class II HYU01_08915 ENOG4105EC3 peptidase S51, dipeptidase E HYU01_08935 ENOG4107QIV Cytochrome c biogenesis protein HYU01_08970 ENOG4106BRA Membrane HYU01_09005 ENOG4105CJ1 ABC, transporter HYU01_09025 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HYU01_09035 ENOG4108IJ0 Aspartate ammonia-lyase HYU01_09040 ENOG4105C6K Malic enzyme HYU01_09115 ENOG4105FVX HYU01_09155 ENOG4105CSR polyphosphate kinase 2 HYU01_09160 ENOG4105DXI Major Facilitator superfamily HYU01_09175 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HYU01_09215 ENOG4105C8J )-transporter HYU01_09230 ENOG4105X5K response regulator receiver protein HYU01_09235 ENOG4105H67 Protein of unknown function (DUF421) HYU01_09255 ENOG4106KE4 Dehydrogenase HYU01_09275 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HYU01_09280 ENOG4105CHR reductase HYU01_09285 ENOG4105CM2 brancheD-chain amino acid aminotransferase HYU01_09290 ENOG4105C7K acetolactate synthase HYU01_09295 ENOG4108ZP8 Acetolactate synthase small subunit HYU01_09300 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HYU01_09310 ENOG4105C7B Threonine dehydratase HYU01_09340 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HYU01_09350 ENOG4105DY9 regulatoR HYU01_09355 ENOG4105CYC Transferase HYU01_09375 ENOG4105F6J Alpha beta hydrolase fold HYU01_09385 ENOG4108J59 Extracellular solute-binding protein, family 5 HYU01_09425 ENOG41068WN HYU01_09445 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HYU01_09450 ENOG4105C72 UPF0176 protein HYU01_09460 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HYU01_09495 ENOG4107RHR regulatoR HYU01_09505 ENOG4105D9N nucleoside HYU01_09510 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HYU01_09540 ENOG4107RAQ aminopeptidase HYU01_09545 ENOG4107STQ Multicopper oxidase HYU01_09590 ENOG4108T5E Copper resistance protein HYU01_09595 ENOG4105KTB nuclear export factor GLE1 HYU01_09605 ENOG4107RT3 EamA-like transporter family HYU01_09610 ENOG4105GZI Transcriptional regulator HYU01_09615 ENOG4108Z40 Transcriptional regulator HYU01_09620 ENOG4107ZXU DSBA oxidoreductase HYU01_09625 ENOG4108TVJ Nitroreductase HYU01_09635 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYU01_09640 ENOG4106F5Q Membrane HYU01_09645 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HYU01_09655 ENOG4105CKI cobalamin synthesis protein HYU01_09675 ENOG4108Z7G MaoC domain protein dehydratase HYU01_09680 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYU01_09690 ENOG4105C0Z ABC transporter HYU01_09695 ENOG4108IV0 ABC, transporter HYU01_09700 ENOG4105C32 Amino acid ABC transporter (Permease) HYU01_09710 ENOG4105SKE transcriptional Regulator LysR family HYU01_09730 ENOG4105YGB Transcriptional regulator HYU01_09740 ENOG4105C4M (Ubiquinol oxidase) subunit I HYU01_09745 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HYU01_09750 ENOG4108JJ9 ABC, transporter HYU01_09755 ENOG4108JJ8 (ABC) transporter HYU01_09795 ENOG4105BZ1 (ABC) transporter HYU01_09800 ENOG4105BZ1 (ABC) transporter HYU01_09805 ENOG4105EFI regulatoR HYU01_09830 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HYU01_09835 ENOG4108ZJ4 polysaccharide deacetylase HYU01_09860 ENOG4105D6E homoserine dehydrogenase HYU01_09885 ENOG4108KGH TRANSCRIPTIONal HYU01_09895 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_09900 ENOG4105BZU Histidine kinase HYU01_09905 ENOG4107VMI polysaccharide deacetylase HYU01_09915 ENOG4105KT7 mgtC SapB transporter HYU01_09920 ENOG4105VRR gCN5-related N-acetyltransferase HYU01_09930 ENOG4105DUU IucA IucC family protein HYU01_09935 ENOG4105CEY Amp-dependent synthetase and ligase HYU01_09950 ENOG4108WBH protein TIM barrel HYU01_09955 ENOG4105YWU small acid-soluble spore protein HYU01_09965 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HYU01_10015 ENOG4105KRN Transcriptional regulator, abrb family HYU01_10025 ENOG4105YVS arsR family transcriptional regulator HYU01_10030 ENOG4107SET aldo keto reductase HYU01_10060 ENOG4105C8Q Methyl-accepting chemotaxis HYU01_10075 ENOG4108K88 Membrane HYU01_10080 ENOG4108WPJ Ferritin-like domain HYU01_10095 ENOG4105DEN Luciferase family HYU01_10115 ENOG4107QM2 Aldo Keto reductase HYU01_10120 ENOG4105CKI cobalamin synthesis protein HYU01_10185 ENOG4105DSE periplasmic solute binding protein HYU01_10195 ENOG4105K4T epimerase HYU01_10205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYU01_10230 ENOG4105CVJ phosphoglycerate mutase HYU01_10250 ENOG4107T5V SNARE associated Golgi HYU01_10265 ENOG4108PJD permease HYU01_10275 ENOG4108S4H thioesterase Superfamily protein HYU01_10285 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HYU01_10305 ENOG4105SXS Protein of unknown function (DUF456) HYU01_10310 ENOG4105C37 (CBS) domain HYU01_10330 ENOG4108Z7R Chaperone CsaA HYU01_10345 ENOG4108ZRV stage ii sporulation protein p HYU01_10355 ENOG4108VXD carboxy-peptidase HYU01_10365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYU01_10390 ENOG4108X4Q Hydrolase HYU01_10400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HYU01_10405 ENOG4107RBS Methyltransferase HYU01_10420 ENOG41087PP glycosyltransferase MGT family HYU01_10425 ENOG4108JYZ YitT family HYU01_10430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYU01_10460 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HYU01_10510 ENOG4105KBJ sporulation protein ytfj HYU01_10555 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HYU01_10560 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_10570 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYU01_10575 ENOG4105EMN RNA polymerase sigma factor HYU01_10600 ENOG4108V06 Glutathione peroxidase HYU01_10615 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HYU01_10635 ENOG4108IUE nitrate reductase beta subunit HYU01_10640 ENOG4105R3A Nitrate reductase HYU01_10665 ENOG4107V6Q Cyclic nucleotide-binding domain HYU01_10670 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYU01_10675 ENOG4105D06 uba thif-type nad fad binding protein HYU01_10680 ENOG4105CVM Molybdenum cofactor synthesis domain protein HYU01_10685 ENOG4108ZAF Molybdopterin HYU01_10710 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HYU01_10715 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HYU01_10720 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HYU01_10725 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HYU01_10735 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HYU01_10770 ENOG4105MCT stage V sporulation protein S HYU01_10790 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HYU01_10810 ENOG4105C5H ABC transporter HYU01_10825 ENOG4108UUM single-stranded DNA-binding protein HYU01_10840 ENOG41061H0 Monooxygenase HYU01_10860 ENOG4107YX5 Pfam:DUF548 HYU01_10865 ENOG4105C75 arginyL-tRNA synthetase HYU01_10890 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HYU01_10905 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HYU01_10910 ENOG4105C5S asparaginyl-tRNA synthetase HYU01_10930 ENOG4105EC2 ftsk spoIIIe HYU01_11020 ENOG4105BZW Glycerate kinase HYU01_11025 ENOG4107QPK )-transporter HYU01_11030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_11035 ENOG41062D9 Histidine kinase HYU01_11050 ENOG4105C8J )-transporter HYU01_11070 ENOG4107XGZ Hydrolase HYU01_11075 ENOG4105CY2 Citrate transporter HYU01_11080 ENOG4105C0A alcohol dehydrogenase HYU01_11095 ENOG4105KD7 acetyltransferase HYU01_11130 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HYU01_11150 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HYU01_11165 ENOG4107RVG penicillin-binding protein HYU01_11170 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HYU01_11175 ENOG4105E9Q Acyl-transferase HYU01_11180 ENOG4108UT2 hemolysin iii HYU01_11190 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HYU01_11200 ENOG4108RCR degv family HYU01_11205 ENOG4105E8R UPF0173 metal-dependent hydrolase HYU01_11210 ENOG4108KF3 Electron transport protein SCO1 SenC HYU01_11215 ENOG4107Y70 Heat shock protein HYU01_11220 ENOG4105CAQ asparagine synthetase HYU01_11240 ENOG4108MES Periplasmic binding protein HYU01_11245 ENOG4105F0I Aminotransferase HYU01_11280 ENOG4105D8X mechanosensitive ion channel HYU01_11285 ENOG4105BZU Histidine kinase HYU01_11290 ENOG4105WH1 Two component transcriptional regulator luxr family HYU01_11300 ENOG4106KNT transcriptional regulator HYU01_11335 ENOG4105CMG Carbohydrate kinase HYU01_11340 ENOG4105CMG Carbohydrate kinase HYU01_11370 ENOG4108IJ8 ABC transporter HYU01_11375 ENOG4105E90 ABC transporter HYU01_11410 ENOG4105C37 (CBS) domain HYU01_11435 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYU01_11450 ENOG4107S4Y M20 DapE family protein YgeY HYU01_11455 ENOG4108TSC N-acetyltransferase HYU01_11460 ENOG4108JUB Transcriptional regulator HYU01_11465 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HYU01_11505 ENOG4108N23 SpoOM-related protein HYU01_11510 ENOG410841Q phosphoesterase PA-phosphatase related protein HYU01_11520 ENOG4105SZ6 Thioredoxin HYU01_11535 ENOG4108IBT Inherit from COG: transposase HYU01_11640 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HYU01_11675 ENOG4105BZ4 penicillin-binding protein HYU01_11685 ENOG4105CZM Major Facilitator HYU01_11690 ENOG4105W8X HesB YadR YfhF-family protein HYU01_11700 ENOG4105DXD 2-methylcitrate dehydratase HYU01_11705 ENOG4105CR4 methylisocitrate lyase HYU01_11710 ENOG4105C1G acyl-Coa dehydrogenase HYU01_11715 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYU01_11725 ENOG4105N14 lysine exporter protein LysE YggA HYU01_11730 ENOG4105E39 Enoyl-CoA hydratase HYU01_11745 ENOG4107RFY SbcCD D subunit HYU01_11750 ENOG4105EYH Exonuclease HYU01_11780 ENOG4105FCD Major Facilitator HYU01_11785 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HYU01_11790 ENOG4105E4F Isochorismate synthase HYU01_11795 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HYU01_11800 ENOG4105WQI isochorismatase HYU01_11810 ENOG4105WQT MbtH domain protein HYU01_11815 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_11830 ENOG4105K70 DNA-binding protein HYU01_11875 ENOG4105FE9 pseudouridine synthase HYU01_11880 ENOG4105C22 threonyL-tRNA synthetase HYU01_11895 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HYU01_11920 ENOG4108D32 Methyltransferase HYU01_11950 ENOG41081I9 integral membrane protein HYU01_11965 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HYU01_11975 ENOG4105EYF MMPL domain protein HYU01_12000 ENOG4105WCN acetyltransferase HYU01_12030 ENOG4105C1Q protoporphyrinogen oxidase HYU01_12040 ENOG41068WN HYU01_12050 ENOG4105VEQ Cold shock protein HYU01_12070 ENOG410667J hydrolase HYU01_12115 ENOG4107V2S Transcriptional regulator HYU01_12120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HYU01_12135 ENOG4105DND Transcriptional regulator HYU01_12140 ENOG4108RPX mosc domain containing protein HYU01_12155 ENOG4105BZ1 (ABC) transporter HYU01_12160 ENOG4105BZ1 (ABC) transporter HYU01_12180 ENOG4108JCI Transcriptional regulator HYU01_12210 ENOG4108KPJ rna polymerase sigma factor HYU01_12235 ENOG4105F32 YngK protein HYU01_12260 ENOG4105RD7 BadF BadG BcrA BcrD HYU01_12270 ENOG4107STF Involved in phosphonate degradation (By similarity) HYU01_12290 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HYU01_12305 ENOG4105C1J atp-dependent rna helicase HYU01_12320 ENOG4108RZE Tetr family transcriptional regulator HYU01_12340 ENOG41088CC tellurite resistance protein tehB HYU01_12350 ENOG4108I0C methyltransferase HYU01_12355 ENOG4107RA9 decarboxylase HYU01_12360 ENOG41090HR transcriptional regulator HYU01_12405 ENOG4105CIN aminoacyl-histidine dipeptidase HYU01_12435 ENOG4107RF6 penicillin-binding protein HYU01_12440 ENOG4107RF6 penicillin-binding protein HYU01_12450 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HYU01_12455 ENOG4105ETE Transcriptional regulator (LacI family HYU01_12465 ENOG4105CK5 oxidoreductase HYU01_12490 ENOG4105D2N Aldolase HYU01_12510 ENOG4105CGH 5'-nucleotidase HYU01_12525 ENOG4105VZ8 Transcriptional regulator HYU01_12540 ENOG4108VXD carboxy-peptidase HYU01_12560 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HYU01_12565 ENOG41067SE Tetr family transcriptional regulator HYU01_12570 ENOG4105C5H ABC transporter HYU01_12580 ENOG4105BZU Histidine kinase HYU01_12590 ENOG4106ANW SMI1_KNR4 HYU01_12600 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HYU01_12615 ENOG4105CJ1 ABC, transporter HYU01_12625 ENOG4107Z3H Transcriptional regulator, TetR family HYU01_12640 ENOG4105C1G acyl-Coa dehydrogenase HYU01_12645 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HYU01_12650 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HYU01_12655 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HYU01_12660 ENOG4105E39 Enoyl-CoA hydratase HYU01_12665 ENOG4107QX3 carboxylase HYU01_12670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYU01_12680 ENOG4105WCN acetyltransferase HYU01_12685 ENOG4105DBI uridine monophosphokinase HYU01_12700 ENOG4105DZ1 carboxypeptidase HYU01_12715 ENOG4105T9C HD domain HYU01_12725 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HYU01_12780 ENOG4105FQP Beta-lactamase HYU01_12790 ENOG4107Y80 Major Facilitator superfamily HYU01_12810 ENOG4105CUV Homoserine Kinase HYU01_12840 ENOG4105CPQ Dehydrogenase HYU01_12855 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HYU01_12860 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HYU01_12955 ENOG4105ETU transcriptional activator (TenA HYU01_13085 ENOG410667J hydrolase HYU01_13095 ENOG4105BZU Histidine kinase HYU01_13100 ENOG4107RF6 penicillin-binding protein HYU01_13120 ENOG4108JJB ABC transporter HYU01_13135 ENOG4108HGU Histidine kinase HYU01_13150 ENOG4105CB2 alcohol dehydrogenase HYU01_13155 ENOG4105CJN penicillin-binding protein HYU01_13165 ENOG4105FQP Beta-lactamase HYU01_13200 ENOG4108V4B ThiJ pfpI HYU01_13230 ENOG4107Y80 Major Facilitator superfamily HYU01_13250 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HYU01_13270 ENOG4107Y9U Membrane HYU01_13305 ENOG4105FCD Major Facilitator HYU01_13315 ENOG4105E09 nadh pyrophosphatase HYU01_13320 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HYU01_13325 ENOG4108Z4K mutator MutT protein HYU01_13360 ENOG4108XI2 Domain of unknown function (DUF1963) HYU01_13395 ENOG4105KWG Pfam:DUF1696 HYU01_13430 ENOG4105PKS Excinuclease abc c subunit domain protein HYU01_13475 ENOG4107VFR oxidoreductase HYU01_13500 ENOG4105PAD Hydrolase HYU01_13520 ENOG4105DY8 decarboxylase HYU01_13535 ENOG4108IUM Glycogen debranching enzyme HYU01_13560 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HYU01_13570 ENOG4105FDR Membrane HYU01_13605 ENOG4108V3A UPF0421 protein HYU01_13625 ENOG4105MSI germination protein ypeb HYU01_13645 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HYU01_13650 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HYU01_13655 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HYU01_13660 ENOG4107Z3H Transcriptional regulator, TetR family HYU01_13690 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HYU01_13710 ENOG4105E98 transcriptional regulator DeoR family HYU01_13730 ENOG41062ES Transcriptional regulator HYU01_13755 ENOG4107QKR Dehydrogenase HYU01_13765 ENOG4107RUY (E1 component), alpha subunit HYU01_13780 ENOG4105E1F short-chain dehydrogenase reductase HYU01_13785 ENOG4105RHY Pfam:UPF0157 HYU01_13810 ENOG4107SQ8 Glycine betaine HYU01_13815 ENOG4108IJ7 Glycine betaine HYU01_13840 ENOG4105E66 phosphoriboisomerase A HYU01_13845 ENOG41082BV acetyltransferase HYU01_13850 ENOG4108M1A Chitin-binding protein HYU01_13895 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HYU01_13925 ENOG4108Z7F N-acetyltransferase HYU01_13945 ENOG4105EEM helicase HYU01_13965 ENOG4105C9U ATP-dependent DNA helicase RecQ HYU01_14015 ENOG4108M1A Chitin-binding protein HYU01_14030 ENOG4105BZG amino acid carrier protein HYU01_14035 ENOG4105C26 Dehydrogenase HYU01_14040 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYU01_14045 ENOG4105CTU Proline racemase HYU01_14050 ENOG4105CTU Proline racemase HYU01_14055 ENOG41080HI glycine oxidase HYU01_14095 ENOG4107T5V SNARE associated Golgi HYU01_14110 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HYU01_14115 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HYU01_14130 ENOG4105DTQ mandelate racemase muconate lactonizing HYU01_14175 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HYU01_14185 ENOG4105BZU Histidine kinase HYU01_14190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_14235 ENOG4105EPR degv family HYU01_14280 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HYU01_14285 ENOG4106K7D Major facilitator family transporter HYU01_14305 ENOG4107BMA Transglycosylase associated protein HYU01_14320 ENOG41089UC methyltransferase, type 11 HYU01_14355 ENOG4105CHM Aminotransferase HYU01_14385 ENOG4105DVE abc transporter atp-binding protein HYU01_14440 ENOG4105C02 permease HYU01_14455 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYU01_14460 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYU01_14465 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HYU01_14490 ENOG4105E09 nadh pyrophosphatase HYU01_14510 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HYU01_14560 ENOG4107VC0 DNA alkylation repair enzyme HYU01_14575 ENOG4107VMI polysaccharide deacetylase HYU01_14585 ENOG4108ZCF integral membrane protein HYU01_14590 ENOG4105E0M Sulfatase HYU01_14595 ENOG4105C5H ABC transporter HYU01_14605 ENOG4105EYF MMPL domain protein HYU01_14610 ENOG4105EYF MMPL domain protein HYU01_14615 ENOG41082JN Transcriptional regulator HYU01_14635 ENOG4105CIH Imidazole acetol-phosphate transaminase HYU01_14640 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HYU01_14645 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HYU01_14680 ENOG41069ER domain protein HYU01_14690 ENOG4105EMN RNA polymerase sigma factor HYU01_14715 ENOG4105D4B ABC, transporter HYU01_14725 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HYU01_14735 ENOG4105DKT Transcriptional regulator HYU01_14740 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HYU01_14750 ENOG41061GT Aldolase HYU01_14770 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HYU01_14800 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HYU01_14805 ENOG4105II7 pyrroline-5-carboxylate reductase HYU01_14815 ENOG4107258 Transcriptional regulator HYU01_14825 ENOG4105E0Y RtcB Protein HYU01_14830 ENOG4105ECK Fatty Acid Desaturase HYU01_14835 ENOG4105G6Z alkaline phosphatase HYU01_14845 ENOG4105VMP Transcriptional regulator HYU01_14860 ENOG41090T1 Membrane HYU01_14870 ENOG4108WCX response regulator HYU01_14880 ENOG41068WN HYU01_14905 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HYU01_14930 ENOG4105CKK Glycosyl transferase, family 2 HYU01_14955 ENOG4105CKK Glycosyl transferase, family 2 HYU01_14965 ENOG4105C8Y Acetylornithine aminotransferase HYU01_15005 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HYU01_15015 ENOG4108TVJ Nitroreductase HYU01_15020 ENOG4105FS7 Transcriptional regulator HYU01_15055 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HYU01_15065 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYU01_15095 ENOG4108XET gCN5-related N-acetyltransferase HYU01_15175 ENOG410635A Membrane HYU01_15180 ENOG4105KNA -acetyltransferase HYU01_15185 ENOG4108IQI permease HYU01_15195 ENOG4105F1N DNA alkylation repair HYU01_15235 ENOG4107RF6 penicillin-binding protein HYU01_15245 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HYU01_15280 ENOG4105P4J Allophanate hydrolase, subunit 1 HYU01_15285 ENOG4107258 Transcriptional regulator HYU01_15295 ENOG4106N3A copper homeostasis protein cutc HYU01_15300 ENOG4108ZRV stage ii sporulation protein p HYU01_15305 ENOG4108ZHR arsR family transcriptional regulator HYU01_15315 ENOG4105FDT acyl-CoA dehydrogenase HYU01_15335 ENOG4105DWD nucleoside recognition domain protein HYU01_15365 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HYU01_15435 ENOG4105E2A Dehydrogenase HYU01_15455 ENOG4108IJ0 Aspartate ammonia-lyase HYU01_15460 ENOG4105HDK L-asparaginase HYU01_15465 ENOG4108IMY Transcriptional regulator HYU01_15475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HYU01_15480 ENOG4105CUB amino acid HYU01_15490 ENOG4105II7 pyrroline-5-carboxylate reductase HYU01_15500 ENOG4105C6K Malic enzyme HYU01_15510 ENOG4108NHD germination protein HYU01_15515 ENOG4108Q8B Spore germination protein HYU01_15545 ENOG4105CSV Glutaminase HYU01_15580 ENOG4105CGH 5'-nucleotidase HYU01_15585 ENOG4105CH6 catalase HYU01_15595 ENOG4105CHJ isochorismatase hydrolase HYU01_15660 ENOG4105CVP deoxyribo-dipyrimidine photolyase HYU01_15675 ENOG4108TWJ NADH dehydrogenase subunit 5 HYU01_15680 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HYU01_15690 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HYU01_15695 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HYU01_15700 ENOG4105DSE periplasmic solute binding protein HYU01_15705 ENOG4105CC5 ABC transporter HYU01_15710 ENOG4105DIK (ABC) transporter HYU01_15740 ENOG4105D6J arsenicaL-resistance protein HYU01_15745 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_15750 ENOG41085FC arsR family transcriptional regulator HYU01_15770 ENOG4105F7F Chaperone HYU01_15780 ENOG4105CHR reductase HYU01_15785 ENOG4108YXU transcriptional regulator AsnC family HYU01_15855 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HYU01_15865 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_15875 ENOG4105IIP Membrane HYU01_15890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_15895 ENOG41062D9 Histidine kinase HYU01_15920 ENOG4105K6H D-cysteine desulfhydrase HYU01_15950 ENOG4105VZ8 Transcriptional regulator HYU01_15965 ENOG4108NNI Beta-lactamase domain-containing protein HYU01_15970 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HYU01_15980 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HYU01_15985 ENOG4105JQZ Methyltransferase HYU01_16000 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HYU01_16005 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HYU01_16020 ENOG4105BZU Histidine kinase HYU01_16035 ENOG4108U05 Transcriptional regulator HYU01_16050 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HYU01_16055 ENOG4105DJB Major Facilitator Superfamily HYU01_16060 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HYU01_16065 ENOG4107QR9 Iron-sulfur cluster binding protein HYU01_16075 ENOG4106P55 Transcriptional regulator HYU01_16085 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HYU01_16120 ENOG4105TRI Hydrolase HYU01_16160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HYU01_16195 ENOG4107QJQ Mate efflux family protein HYU01_16210 ENOG4105EQ0 Major Facilitator superfamily HYU01_16215 ENOG4108JGH Tetr family transcriptional regulator HYU01_16225 ENOG4105C44 Serine transporter HYU01_16230 ENOG4105EJQ L-serine dehydratase HYU01_16245 ENOG4108JPW Aminotransferase HYU01_16270 ENOG4105DVH amino acid HYU01_16285 ENOG4108JQ1 Dehydrogenase HYU01_16305 ENOG4108AEY RNA polymerase sigma factor HYU01_16320 ENOG41082W1 Cupin 2, conserved barrel domain protein HYU01_16330 ENOG410874W AraC family transcriptional regulator HYU01_16345 ENOG4105HIR S-layer domain protein HYU01_16385 ENOG4108ISG Major Facilitator HYU01_16395 ENOG4107MII Sugar-specific transcriptional regulator TrmB HYU01_16400 ENOG4105CZM Major Facilitator HYU01_16420 ENOG4105DA5 (ABC) transporter HYU01_16425 ENOG41069JR HYU01_16435 ENOG4105RXJ HYU01_16440 ENOG4105KPY Small multidrug resistance protein HYU01_16445 ENOG4105KBX Transcriptional regulator, TetR family HYU01_16460 ENOG4105CRW Short chain fatty acid transporter HYU01_16470 ENOG4105DYS nad(p)h dehydrogenase (quinone) HYU01_16500 ENOG4108JJB ABC transporter HYU01_16505 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HYU01_16530 ENOG4108K8S endonuclease I HYU01_16545 ENOG41067QW Transcriptional regulator HYU01_16555 ENOG4108Z66 YbaK ebsC protein HYU01_16560 ENOG4105CUT histidyl-tRNA synthetase HYU01_16575 ENOG4105KVH Transcriptional regulator HYU01_16580 ENOG4108RCM Nitroreductase HYU01_16600 ENOG4108PSK reductase HYU01_16610 ENOG4105CJ1 ABC, transporter HYU01_16670 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_16675 ENOG4105DKQ ROK family HYU01_16680 ENOG4106UW1 Major Facilitator superfamily HYU01_16685 ENOG4108UW5 maltose o-acetyltransferase HYU01_16695 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HYU01_16705 ENOG4105C31 Tryptophanyl-tRNA synthetase HYU01_16710 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HYU01_16735 ENOG4105DMQ Methyltransferase HYU01_16745 ENOG4105EV4 Multidrug resistance protein mdtH HYU01_16775 ENOG4105C37 (CBS) domain HYU01_16790 ENOG4105DDN Pentapeptide repeat-containing protein HYU01_16795 ENOG4105XDF Protein of unknown function (DUF1272) HYU01_16800 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HYU01_16805 ENOG4105CMG Carbohydrate kinase HYU01_16810 ENOG4105C6Z Gluconate HYU01_16815 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HYU01_16830 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HYU01_16835 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HYU01_16840 ENOG4105CIS alcohol dehydrogenase HYU01_16845 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HYU01_16860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HYU01_16865 ENOG4105D4Y metalloprotease HYU01_16885 ENOG4105CV8 reductase HYU01_16890 ENOG4105F27 Major Facilitator HYU01_16905 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HYU01_16910 ENOG4105C44 Serine transporter HYU01_16940 ENOG4105KVH Transcriptional regulator HYU01_16945 ENOG4108TZY GntR Family Transcriptional Regulator HYU01_16950 ENOG4105D9R oxidoreductase HYU01_16955 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HYU01_16960 ENOG4105KVH Transcriptional regulator HYU01_16965 ENOG4105KVH Transcriptional regulator HYU01_17000 ENOG4105JAB phenazine biosynthesis protein, phzf family HYU01_17010 ENOG4105CHR reductase HYU01_17030 ENOG4105KVH Transcriptional regulator HYU01_17100 ENOG4105KAF membrAne HYU01_17130 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HYU01_17150 ENOG4107YXZ hydrolase, family 25 HYU01_17175 ENOG4105ED2 Beta-lactamase HYU01_17185 ENOG4105H3G oxidoreductase HYU01_17225 ENOG4105CIS alcohol dehydrogenase HYU01_17260 ENOG4108TN2 lmbE family HYU01_17270 ENOG4107R3E Citrate transporter HYU01_17290 ENOG4108MES Periplasmic binding protein HYU01_17300 ENOG4105EHG Permease protein HYU01_17305 ENOG4105DQ5 transport system permease protein HYU01_17310 ENOG4105NX3 Membrane HYU01_17315 ENOG4107ZY0 Phenazine biosynthesis-like protein HYU01_17335 ENOG4107CUJ Protein of unknown function (DUF2690) HYU01_17345 ENOG4107V2S Transcriptional regulator HYU01_17365 ENOG4105C98 muts2 protein HYU01_17380 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HYU01_17385 ENOG4105DPN Oligoendopeptidase f HYU01_17390 ENOG4108A04 Beta-lactamase HYU01_17420 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HYU01_17445 ENOG41082BM Transcriptional regulator, arsr family HYU01_17450 ENOG4105CIS alcohol dehydrogenase HYU01_17485 ENOG4105C09 Bile acid HYU01_17490 ENOG4105CQB FAD linked oxidase domain protein HYU01_17515 ENOG4108UT6 Transferase hexapeptide repeat containing protein HYU01_17525 ENOG4105K64 Glycosyl transferase, family 2 HYU01_17530 ENOG4105E39 Enoyl-CoA hydratase HYU01_17540 ENOG4105KT7 mgtC SapB transporter HYU01_17550 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_17555 ENOG41073R8 VanW family HYU01_17565 ENOG4108R1P HYU01_17585 ENOG4105VEQ Cold shock protein HYU01_17605 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HYU01_17625 ENOG410904N short-chain dehydrogenase reductase HYU01_17650 ENOG4108IA2 Sodium pantothenate symporter HYU01_17655 ENOG4105RG0 Membrane HYU01_17660 ENOG4105C26 Dehydrogenase HYU01_17665 ENOG4105CHR reductase HYU01_17675 ENOG4105EWU Squalene--hopene cyclase HYU01_17685 ENOG4105FR1 rard protein HYU01_17690 ENOG410696E Membrane HYU01_17705 ENOG4105D1F ATP-binding protein HYU01_17715 ENOG4108ZAF Molybdopterin HYU01_17720 ENOG4105CVM Molybdenum cofactor synthesis domain protein HYU01_17725 ENOG4105D06 uba thif-type nad fad binding protein HYU01_17730 ENOG4105TMB Formate nitrite transporter HYU01_17740 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HYU01_17745 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HYU01_17755 ENOG4108JB9 formate dehydrogenase HYU01_17765 ENOG4105E1K spore germination protein HYU01_17820 ENOG4107QJT sodium dicarboxylate symporter HYU01_17825 ENOG4108KGH TRANSCRIPTIONal HYU01_17835 ENOG4105EMN RNA polymerase sigma factor HYU01_17855 ENOG4105CIG ABC transporter HYU01_17865 ENOG4105D9R oxidoreductase HYU01_17875 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYU01_17880 ENOG4105K4P CoA-binding domain protein HYU01_17885 ENOG4105C0H protease HYU01_17890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_17900 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HYU01_17905 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HYU01_17910 ENOG4105W8X HesB YadR YfhF-family protein HYU01_17940 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HYU01_17945 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HYU01_17955 ENOG4108JJA ABC, transporter HYU01_17960 ENOG4108I0Z Aconitate hydratase HYU01_17985 ENOG4105E5W Transporter HYU01_17995 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HYU01_18015 ENOG4107F3J Amp-dependent synthetase and ligase HYU01_18020 ENOG4107ZYJ bioY protein HYU01_18025 ENOG4105CEY Amp-dependent synthetase and ligase HYU01_18070 ENOG4107AYK membrAne HYU01_18080 ENOG4105BZU Histidine kinase HYU01_18085 ENOG4105FBA Phospholipase Carboxylesterase HYU01_18090 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HYU01_18095 ENOG4105CK7 Sodium proline symporter HYU01_18100 ENOG4105CBC glutamate synthase HYU01_18105 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYU01_18110 ENOG4108VJ1 Transcriptional regulator (CarD family HYU01_18115 ENOG4108903 Formimidoylglutamase HYU01_18140 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) HYU01_18220 ENOG4107QIV Cytochrome c biogenesis protein HYU01_18230 ENOG4107RSM transcriptional regulator HYU01_18235 ENOG4105VAW lrga family HYU01_18240 ENOG41067MG lrgb family HYU01_18270 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HYU01_18285 ENOG4105BZ1 (ABC) transporter HYU01_18290 ENOG4105BZ1 (ABC) transporter HYU01_18310 ENOG4105D7V transposase HYU01_18325 ENOG4105D5T phosphonate abc transporter HYU01_18345 ENOG4108SVB resolvase HYU01_18365 ENOG4105K7K Transcriptional regulator HYU01_18410 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HYU01_18415 ENOG4105XSJ toxin secretion phage lysis holin HYU01_18625 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HYU01_18740 ENOG4105C5F glutamine synthetase HYU01_18745 ENOG4105KV4 Transcriptional regulator HYU01_18750 ENOG4105CXI aluminum resistance protein HYU01_18755 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HYU01_18760 ENOG4105EN6 Membrane HYU01_18770 ENOG4106F1P AAA ATPase, central domain protein HYU01_18800 ENOG41069ER domain protein HYU01_18805 ENOG4105DM4 PTS System HYU01_18810 ENOG4105DE4 1-phosphofructokinase HYU01_18815 ENOG4105E98 transcriptional regulator DeoR family HYU01_18825 ENOG4108SJC Membrane HYU01_18840 ENOG4105C85 amino acid HYU01_18860 ENOG4105TMB Formate nitrite transporter HYU01_18865 ENOG4105K70 DNA-binding protein HYU01_18870 ENOG4105C59 p-type ATPase HYU01_18875 ENOG410681U heavy metal transport detoxification protein HYU01_18880 ENOG4105VPX protein, conserved in bacteria HYU01_18890 ENOG4105NIV Esterase HYU01_18895 ENOG4105E0A ABC, transporter HYU01_18925 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYU01_18930 ENOG4105D03 DNA-3-methyladenine glycosylase II HYU01_18960 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_18965 ENOG4105BZU Histidine kinase HYU01_18980 ENOG41067MG lrgb family HYU01_18995 ENOG4107TTQ Alpha beta hydrolase fold HYU01_19000 ENOG4107YEI lmbE family HYU01_19020 ENOG4105F0V Cell wall hydrolase HYU01_19025 ENOG4107R6R udp-galactopyranose mutase HYU01_19035 ENOG410890F Dynamin family HYU01_19045 ENOG4107QHE Choloylglycine hydrolase HYU01_19070 ENOG4105DA5 (ABC) transporter HYU01_19095 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HYU01_19100 ENOG4105DQU oxidoreductase, subunit beta HYU01_19105 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HYU01_19110 ENOG4108IGT Dipeptidase HYU01_19115 ENOG4105MCT stage V sporulation protein S HYU01_19120 ENOG4105D48 metallophosphoesterase HYU01_19145 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HYU01_19160 ENOG4105XZV Protein of unknown function (DUF3243) HYU01_19165 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HYU01_19185 ENOG4105UIB (ABC) transporter HYU01_19190 ENOG4105UIB (ABC) transporter HYU01_19195 ENOG4108JQ9 ABC transporter HYU01_19200 ENOG4105DIH basic membrane HYU01_19205 ENOG4105FDP GntR family transcriptional regulator HYU01_19210 ENOG4107QZI cell division protein FtsK HYU01_19220 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HYU01_19235 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYU01_19245 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HYU01_19250 ENOG4108S0H Dipicolinic acid synthetase, b subunit HYU01_19255 ENOG4105E35 Dipicolinate synthase subunit A HYU01_19265 ENOG4105C1V Peptidase, M16 HYU01_19285 ENOG4105DTN riboflavin biosynthesis protein ribF HYU01_19290 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HYU01_19300 ENOG4105W7A Protein of unknown function (DUF503) HYU01_19310 ENOG4105VHM ribosomal protein HYU01_19315 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HYU01_19320 ENOG4105CHV Transcription elongation factor NusA HYU01_19330 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HYU01_19340 ENOG4105DZP Membrane-associated zinc metalloprotease HYU01_19345 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HYU01_19350 ENOG4105KNE Phosphatidate cytidylyltransferase HYU01_19395 ENOG4108HE4 integrase family HYU01_19405 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HYU01_19415 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HYU01_19430 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HYU01_19455 ENOG4105VB6 UPF0109 protein HYU01_19475 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HYU01_19480 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HYU01_19495 ENOG4105CHR reductase HYU01_19500 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HYU01_19515 ENOG4105CB5 ATP-dependent DNA helicase recG HYU01_19520 ENOG4105DP4 dak2 domain fusion protein ylov HYU01_19525 ENOG4108ZAA Alkaline-shock protein HYU01_19540 ENOG4105FJ0 thiamine HYU01_19545 ENOG4105DJV ribulose-phosphate 3-epimerase HYU01_19550 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HYU01_19555 ENOG4105D9P serine threonine protein kinase HYU01_19560 ENOG4108ZF3 Phosphatase HYU01_19570 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HYU01_19580 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYU01_19585 ENOG4105C25 Primosomal protein n' HYU01_19590 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HYU01_19610 ENOG4105DSJ YicC domain protein HYU01_19620 ENOG4105F23 Fibronectin-binding protein HYU01_19625 ENOG4105DC7 peptidase M24 HYU01_19680 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HYU01_19705 ENOG4105C34 Pseudouridine synthase HYU01_19720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HYU01_19730 ENOG4105DBK s4 domain protein HYU01_19735 ENOG41067XK integral membrane protein HYU01_19745 ENOG4105DFA alanine racemase domain protein HYU01_19750 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HYU01_19755 ENOG4105WR5 sporulation protein, YlmC YmxH family HYU01_19765 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_19775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HYU01_19780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HYU01_19790 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HYU01_19795 ENOG4105D4A Cell wall formation (By similarity) HYU01_19800 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HYU01_19805 ENOG4105CNI cell division protein FtsW HYU01_19820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HYU01_19825 ENOG4105CJN penicillin-binding protein HYU01_19830 ENOG4105CJN penicillin-binding protein HYU01_19835 ENOG41068DC Essential cell division protein (By similarity) HYU01_19870 ENOG4105KNH Nucleic acid-binding protein HYU01_19920 ENOG4105XSJ toxin secretion phage lysis holin HYU01_20000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYU01_20010 ENOG4105CAR Terminase, large subunit HYU01_20110 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HYU01_20130 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_20180 ENOG4108IMY Transcriptional regulator HYU01_20220 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) HYU01_20230 ENOG41063PX domain protein HYU01_20235 ENOG4105D78 K07001 NTE family protein HYU01_20240 ENOG4105H20 Sporulation integral membrane protein YlbJ HYU01_20250 ENOG4106H78 methyltransferase HYU01_20270 ENOG4107TB6 phosphoglycerate mutase HYU01_20285 ENOG4106UY4 Inherit from COG: Scp-like extracellular HYU01_20335 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HYU01_20340 ENOG4105CNI cell division protein FtsW HYU01_20355 ENOG4108IAB Phoh family HYU01_20375 ENOG4105QA2 HYU01_20380 ENOG4105CI3 gtp-binding protein typa HYU01_20390 ENOG4105ECY inositol monophosphatase HYU01_20410 ENOG4105CXN decarboxylase HYU01_20455 ENOG4105CPP Dehydrogenase, E1 component HYU01_20470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYU01_20475 ENOG4108X4Q Hydrolase HYU01_20485 ENOG4105CN5 Metallo-Beta-Lactamase HYU01_20490 ENOG4107ZYR domain protein HYU01_20525 ENOG4108XRC Protein of unknown function (DUF458) HYU01_20535 ENOG4107IN1 Protein of unknown function (DUF1797) HYU01_20550 ENOG4105EPM Diguanylate phosphodiesterase HYU01_20555 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HYU01_20580 ENOG4105UIN HYU01_20635 ENOG4108HGU Histidine kinase HYU01_20645 ENOG4105CHM Aminotransferase HYU01_20650 ENOG4105FKQ transcriptional regulator HYU01_20655 ENOG4105EG2 ABC transporter, permease HYU01_20665 ENOG4107FKK extracellular solute-binding protein family 1 HYU01_20675 ENOG4105CG3 alpha amylase, catalytic region HYU01_20720 ENOG4105CHU acetyl-coa acetyltransferase HYU01_20755 ENOG4105K7K Transcriptional regulator HYU01_20760 ENOG4105DTD Dehydrogenase HYU01_20770 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HYU01_20780 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HYU01_20805 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HYU01_20825 ENOG4106TD9 Diguanylate cyclase HYU01_20845 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HYU01_20860 ENOG4105CID antiterminator HYU01_20870 ENOG4105FDP GntR family transcriptional regulator HYU01_20880 ENOG4105CE4 GlcNAc 6-P deacetylase HYU01_20915 ENOG4107ZE5 PPIases accelerate the folding of proteins HYU01_20920 ENOG4105PTM secreted protein HYU01_20925 ENOG4105J7I hydrolase HYU01_20935 ENOG4105G6R Stage v sporulation protein ae HYU01_20945 ENOG4105CZ3 stage V sporulation protein ad HYU01_20950 ENOG41090VF Stage v sporulation protein ac HYU01_20970 ENOG4105C8J )-transporter HYU01_20975 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_20985 ENOG41082AN stage II sporulation protein HYU01_20990 ENOG4105DZ1 carboxypeptidase HYU01_20995 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HYU01_21000 ENOG4105DVE abc transporter atp-binding protein HYU01_21030 ENOG4105D7N magnesium and cobalt transport protein CorA HYU01_21055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYU01_21065 ENOG4105I3K Ferric uptake regulator, Fur family HYU01_21070 ENOG4105MZ9 stage II sporulation protein m HYU01_21090 ENOG4105CPC Aldo Keto reductase HYU01_21100 ENOG4105RHY Pfam:UPF0157 HYU01_21120 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HYU01_21130 ENOG4105ETE Transcriptional regulator (LacI family HYU01_21135 ENOG4108YM7 Gcn5-related n-acetyltransferase HYU01_21155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HYU01_21160 ENOG4108R6K riboflavin synthase, subunit alpha HYU01_21180 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HYU01_21185 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HYU01_21190 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HYU01_21195 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HYU01_21205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYU01_21215 ENOG4105DFD Na H antiporter HYU01_21220 ENOG4105CGH 5'-nucleotidase HYU01_21260 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HYU01_21275 ENOG4108IXY short-chain dehydrogenase reductase HYU01_21280 ENOG41069FQ Metallo-beta-lactamase superfamily HYU01_21285 ENOG4105II7 pyrroline-5-carboxylate reductase HYU01_21290 ENOG4105EJQ L-serine dehydratase HYU01_21315 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HYU01_21325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HYU01_21330 ENOG4105D9U N-acetyltransferase HYU01_21345 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HYU01_21350 ENOG4108QEG Membrane HYU01_21355 ENOG4105CDA abc transporter atp-binding protein HYU01_21360 ENOG4105E5Q amino acid AbC transporter HYU01_21365 ENOG4108HW3 (ABC) transporter HYU01_21375 ENOG4105G7B Protein of unknown function (DUF2992) HYU01_21390 ENOG4105C7S Dehydrogenase HYU01_21395 ENOG4105CPP Dehydrogenase, E1 component HYU01_21415 ENOG4107RDP Dehydrogenase HYU01_21425 ENOG4108JUB Transcriptional regulator HYU01_21435 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HYU01_21450 ENOG4107QQR Sporulation HYU01_21455 ENOG4105S1Z Stage IV sporulation protein B HYU01_21460 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HYU01_21470 ENOG4105DX0 Hemolysin A HYU01_21480 ENOG4105CTB Polyprenyl synthetase HYU01_21505 ENOG4108ZSR alkaline shock protein HYU01_21510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HYU01_21530 ENOG410644B Stage III sporulation protein af HYU01_21540 ENOG4105KQ4 Stage iii sporulation protein ad HYU01_21545 ENOG4108CQH stage III sporulation protein AC HYU01_21550 ENOG4105KR5 Stage iii sporulation protein HYU01_21555 ENOG4105CD2 stage iii sporulation protein aa HYU01_21580 ENOG4105DC7 peptidase M24 HYU01_21595 ENOG4105CBJ Metal-dependent enzyme HYU01_21605 ENOG4107YBY Hydrolase HYU01_21625 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HYU01_21630 ENOG4105WZW rhodanese family HYU01_21650 ENOG41080TC multidrug resistance protein HYU01_21685 ENOG4105CJ1 ABC, transporter HYU01_21690 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HYU01_21720 ENOG4105C0D helicase HYU01_21840 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HYU01_21855 ENOG4105C28 cystathionine HYU01_21860 ENOG4105C28 cystathionine HYU01_21885 ENOG4105C5X domain protein HYU01_21895 ENOG4105DKQ ROK family HYU01_21905 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HYU01_21925 ENOG4108UTW Plays a role in the regulation of phosphate uptake HYU01_21930 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HYU01_21935 ENOG4105E2Z phosphate ABC transporter (Permease HYU01_21940 ENOG4105C8U phosphate abc transporter HYU01_21945 ENOG4105PWN phosphate abc transporter HYU01_21950 ENOG4107RF6 penicillin-binding protein HYU01_21960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYU01_21985 ENOG4105N80 Ferric uptake regulator, Fur family HYU01_21995 ENOG4105FDK ABC transporter HYU01_22000 ENOG4108JYZ YitT family HYU01_22005 ENOG41069ZM Protein of unknown function (DUF2624) HYU01_22030 ENOG4105EGD dinuclear metal center protein, YbgI family HYU01_22045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_22050 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HYU01_22075 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HYU01_22080 ENOG4105KG3 cytidine deaminase HYU01_22085 ENOG4107YR5 Diacylglycerol kinase HYU01_22095 ENOG4105CTJ Metal Dependent Phosphohydrolase HYU01_22100 ENOG4105C9A Phoh family HYU01_22110 ENOG41068P3 sporulation protein YqfC HYU01_22115 ENOG4105KTH gatB Yqey HYU01_22125 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HYU01_22130 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HYU01_22150 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HYU01_22160 ENOG4105CSA Coproporphyrinogen iii oxidase HYU01_22165 ENOG4105KVH Transcriptional regulator HYU01_22190 ENOG4105TQK DNA polymerase iii, delta' subunit HYU01_22205 ENOG4108UK2 deaminase HYU01_22210 ENOG4105KQC Competence protein HYU01_22220 ENOG4105DXX methyltransferase HYU01_22230 ENOG4108WF2 Metal Dependent Phosphohydrolase HYU01_22240 ENOG410812S Rna-binding protein HYU01_22250 ENOG4105CQW ribosome biogenesis GTPase YqeH HYU01_22255 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HYU01_22270 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_22290 ENOG4108TVJ Nitroreductase HYU01_22305 ENOG4105G6Z alkaline phosphatase HYU01_22315 ENOG4108MUZ hydrolase HYU01_22350 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HYU01_22365 ENOG4105MIR Phenylalanine 4-monooxygenase HYU01_22375 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_22415 ENOG4105S6R Iron-hydroxamate transporter permease subunit HYU01_22420 ENOG4108V5C ABC transporter HYU01_22430 ENOG4108EKI Dehydrogenase HYU01_22435 ENOG4105C28 cystathionine HYU01_22465 ENOG4107XRG penicillin-binding protein HYU01_22480 ENOG4105CFP Peptidase U32 HYU01_22485 ENOG4105XYU peptidase (U32 family) HYU01_22490 ENOG4108VQJ O-methyltransferase HYU01_22495 ENOG4105HHA aminodeoxychorismate lyase HYU01_22515 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HYU01_22525 ENOG4105C02 permease HYU01_22540 ENOG41060CR HYU01_22545 ENOG4105C7H Helicase, RecD TraA family HYU01_22555 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HYU01_22560 ENOG4105C3J Cysteine desulfurase HYU01_22570 ENOG4105D1H recombination factor protein RarA HYU01_22575 ENOG4108VCI transcription factor, rsfa family HYU01_22580 ENOG4105CUZ uba thif-type nad fad binding protein HYU01_22590 ENOG4105CUT histidyl-tRNA synthetase HYU01_22605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HYU01_22615 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HYU01_22620 ENOG41076HS cation diffusion facilitator family transporter HYU01_22625 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HYU01_22635 ENOG4105CKP Polysaccharide Biosynthesis Protein HYU01_22640 ENOG4108QG2 Membrane HYU01_22650 ENOG4105VIE preprotein translocase, subunit YajC HYU01_22665 ENOG41061AI Protein of unknown function (DUF2905) HYU01_22680 ENOG4108HUF Transporter HYU01_22690 ENOG4108IPJ Membrane HYU01_22695 ENOG4108IPJ Membrane HYU01_22700 ENOG41082BM Transcriptional regulator, arsr family HYU01_22725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HYU01_22730 ENOG4108IYU L-aspartate oxidase HYU01_22745 ENOG4108RPX mosc domain containing protein HYU01_22750 ENOG4105CQC Prephenate dehydratase HYU01_22770 ENOG4105EWM Histidine kinase HYU01_22785 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HYU01_22800 ENOG4105X36 (ribosomal) protein HYU01_22810 ENOG4105C03 ribonuclease HYU01_22825 ENOG4107QMS site-determining protein HYU01_22840 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HYU01_22845 ENOG4105DFF Rod shape-determining protein mreb HYU01_22865 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HYU01_22870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HYU01_22880 ENOG41068KH stage VI sporulation protein D HYU01_22890 ENOG4105D52 delta-aminolevulinic acid dehydratase HYU01_22915 ENOG4105K56 Transcriptional regulator HYU01_22935 ENOG4108IUQ atp-dependent protease HYU01_22960 ENOG4108QCI YvbH-like oligomerisation region HYU01_22980 ENOG4105M59 Phosphodiesterase, mj0936 family HYU01_22985 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HYU01_22995 ENOG4108XJQ germination protein HYU01_23005 ENOG4108PCX Major Facilitator HYU01_23015 ENOG4105KBX Transcriptional regulator, TetR family HYU01_23035 ENOG4105PFC Transcriptional regulator HYU01_23050 ENOG4105DZC cytosine deaminase HYU01_23055 ENOG4105DZC cytosine deaminase HYU01_23060 ENOG4105DEF Extracellular solute-binding protein, family 5 HYU01_23065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYU01_23080 ENOG4108JQ7 (ABC) transporter HYU01_23085 ENOG4108HRK Histidine kinase HYU01_23090 ENOG4105DY9 regulatoR HYU01_23105 ENOG41067S9 phage shock protein C, PspC HYU01_23110 ENOG4108JCI Transcriptional regulator HYU01_23120 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HYU01_23125 ENOG4108Z40 Transcriptional regulator HYU01_23130 ENOG4105RHA ABC transporter, permease HYU01_23140 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HYU01_23150 ENOG4105E14 MotA TolQ exbB proton channel HYU01_23155 ENOG4108VXD carboxy-peptidase HYU01_23165 ENOG4105E33 succinate dehydrogenase HYU01_23175 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HYU01_23190 ENOG4105K63 Thioredoxin HYU01_23195 ENOG4105C10 Electron transfer flavoprotein HYU01_23200 ENOG4105BZJ Electron transfer flavoprotein HYU01_23205 ENOG41060WC Enoyl-CoA hydratase HYU01_23210 ENOG4107Z3H Transcriptional regulator, TetR family HYU01_23215 ENOG4105CEY Amp-dependent synthetase and ligase HYU01_23230 ENOG4105J76 Periplasmic binding protein HYU01_23235 ENOG4105S6R Iron-hydroxamate transporter permease subunit HYU01_23280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_23295 ENOG4105DR4 Methyltransferase HYU01_23310 ENOG4105KFN sortase, SrtB family HYU01_23315 ENOG4105E0A ABC, transporter HYU01_23330 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HYU01_23340 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HYU01_23350 ENOG4105FE9 pseudouridine synthase HYU01_23365 ENOG4105DCG PHP domain protein HYU01_23400 ENOG4105C5S asparaginyl-tRNA synthetase HYU01_23405 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HYU01_23415 ENOG4108RWN rrna methyltransferase HYU01_23450 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYU01_23455 ENOG4105CW7 secretion protein, HlyD family HYU01_23460 ENOG4108JGH Tetr family transcriptional regulator HYU01_23465 ENOG4105CN9 Peptidase m42 family protein HYU01_23485 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HYU01_23490 ENOG4105C22 threonyL-tRNA synthetase HYU01_23495 ENOG4108TDW sporulation protein YtxC HYU01_23515 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HYU01_23520 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HYU01_23525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HYU01_23535 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HYU01_23540 ENOG4105C2M dna polymerase I HYU01_23545 ENOG4105BZU Histidine kinase HYU01_23550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_23575 ENOG4108HMX isocitrate dehydrogenase (NADP) HYU01_23580 ENOG4105BZN citrate synthase HYU01_23590 ENOG4108REF Sporulation integral membrane protein ytvi HYU01_23600 ENOG4105FS0 cytoplasmic membrane protein HYU01_23625 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HYU01_23630 ENOG4105C6K Malic enzyme HYU01_23635 ENOG4105C0B DNA polymerase III (alpha subunit) HYU01_23640 ENOG4105VV2 HYU01_23650 ENOG4105SFS phosphoesterase RecJ domain protein HYU01_23685 ENOG4105DC7 peptidase M24 HYU01_23720 ENOG4105Z7P Acetyltransferase (GNAT) family HYU01_23725 ENOG41082W1 Cupin 2, conserved barrel domain protein HYU01_23735 ENOG4105VZ8 Transcriptional regulator HYU01_23755 ENOG4107YZX Universal stress protein HYU01_23800 ENOG4108JYZ YitT family HYU01_23820 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HYU01_23830 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HYU01_23835 ENOG4105KBJ sporulation protein ytfj HYU01_23850 ENOG4105EFZ amidohydrolase HYU01_23860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYU01_23885 ENOG4106KR7 LysR family Transcriptional regulator HYU01_23905 ENOG4105C28 cystathionine HYU01_23925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HYU01_23935 ENOG4105EMN RNA polymerase sigma factor HYU01_23950 ENOG4105F1V Acetoin utilization protein HYU01_23955 ENOG4105W87 Cbs domain HYU01_23960 ENOG4105DGU Histone deacetylase HYU01_23970 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HYU01_23980 ENOG4107SNB ankyrin repeat protein YahD HYU01_23985 ENOG4105EP9 oxidoreductase HYU01_24015 ENOG4105ETE Transcriptional regulator (LacI family HYU01_24035 ENOG4105C88 aminopeptidase HYU01_24080 ENOG4108VDD TRNA binding domain protein HYU01_24110 ENOG4105C8F Beta-lactamase domain protein HYU01_24125 ENOG4108V15 phosphotransferase enzyme family HYU01_24130 ENOG4108IUM Glycogen debranching enzyme HYU01_24140 ENOG4107QSE Dipeptidase HYU01_24145 ENOG4105YW5 deoR family transcriptional regulator HYU01_24160 ENOG4105CBX hi0933 family HYU01_24195 ENOG4108VJ1 Transcriptional regulator (CarD family HYU01_24200 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HYU01_24205 ENOG4105CSC Glucose uptake protein HYU01_24220 ENOG4108ZAF Molybdopterin HYU01_24225 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HYU01_24230 ENOG4105CVM Molybdenum cofactor synthesis domain protein HYU01_24240 ENOG4105D06 uba thif-type nad fad binding protein HYU01_24245 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYU01_24265 ENOG41085GJ domain protein HYU01_24275 ENOG4105DWV Homoserine O-trans-acetylase HYU01_24285 ENOG4108B31 Spore germination protein HYU01_24320 ENOG410605W Major Facilitator HYU01_24325 ENOG4107S91 Sodium hydrogen exchanger HYU01_24330 ENOG4105NCW Trka-c domain protein HYU01_24345 ENOG4105C19 ABC transporter HYU01_24365 ENOG4105N5T Radical SAM Protein HYU01_24375 ENOG4105DA5 (ABC) transporter HYU01_24405 ENOG4105E8V Alpha Beta Hydrolase Fold protein HYU01_24410 ENOG4108Z0R Transferase HYU01_24415 ENOG4105YVM Phosphoesterase, PA-phosphatase related HYU01_24420 ENOG4105BZF Glycosyl transferase (Group 1 HYU01_24430 ENOG4108RIR Molybdenum cofactor biosynthesis protein HYU01_24480 ENOG4105EGD dinuclear metal center protein, YbgI family HYU01_24485 ENOG4105BZU Histidine kinase HYU01_24490 ENOG4105BZU Histidine kinase HYU01_24495 ENOG4107S9D Alpha beta hydrolase HYU01_24515 ENOG4105D2X ABC transporter substrate-binding protein HYU01_24525 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HYU01_24580 ENOG4108V2W Carbonate dehydratase HYU01_24585 ENOG4105C4M (Ubiquinol oxidase) subunit I HYU01_24590 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HYU01_24640 ENOG41087YS Phage shock protein A HYU01_24675 ENOG4105BZU Histidine kinase HYU01_24680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_24705 ENOG4108UGV hypoxanthine phosphoribosyltransferase HYU01_24710 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HYU01_24745 ENOG4107ZTW SNARE associated Golgi HYU01_24760 ENOG4105C19 ABC transporter HYU01_24765 ENOG41086D8 Transcriptional regulator HYU01_24805 ENOG4105C6Z Gluconate HYU01_24810 ENOG4105FDP GntR family transcriptional regulator HYU01_24830 ENOG41069H0 dihydroorotase EC 3.5.2.3 HYU01_24860 ENOG4105DTQ mandelate racemase muconate lactonizing HYU01_24870 ENOG4108IPT Naphthoate synthase HYU01_24875 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HYU01_24880 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HYU01_24885 ENOG4105E4F Isochorismate synthase HYU01_24895 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HYU01_24905 ENOG4105VEQ Cold shock protein HYU01_24930 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HYU01_24940 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HYU01_24955 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HYU01_25050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HYU01_25085 ENOG4105KT7 mgtC SapB transporter HYU01_25090 ENOG4107PBV potassium channel HYU01_25100 ENOG4107QYV phosphohexose isomerase HYU01_25105 ENOG4105WG9 Conserved Protein HYU01_25115 ENOG4105CHM Aminotransferase HYU01_25120 ENOG4108ZB6 transcriptional regulator AsnC family HYU01_25125 ENOG4105C5I Dehydrogenase HYU01_25130 ENOG4108MUZ hydrolase HYU01_25140 ENOG4105C87 Aminotransferase class I and II HYU01_25155 ENOG4105Y38 Kinase-associated protein B HYU01_25165 ENOG4107R3E Citrate transporter HYU01_25180 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HYU01_25185 ENOG4105KA0 thioesterase Superfamily protein HYU01_25205 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HYU01_25225 ENOG41069ER domain protein HYU01_25240 ENOG4105CEP NADH dehydrogenase HYU01_25270 ENOG4105EWC Purine nucleoside phosphorylase HYU01_25285 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HYU01_25310 ENOG4108JJA ABC, transporter HYU01_25315 ENOG4105C4B ABC transporter, permease HYU01_25320 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HYU01_25365 ENOG41083MR nifu domain-containing protein HYU01_25380 ENOG4108W5N phosphatidylglycerophosphatase a HYU01_25395 ENOG4105DYS nad(p)h dehydrogenase (quinone) HYU01_25400 ENOG4105D4U had-superfamily hydrolase, subfamily iia HYU01_25415 ENOG4105CBT Fructose-1,6-bisphosphatase HYU01_25430 ENOG4105MMD transcriptional regulator HYU01_25435 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HYU01_25440 ENOG4107TXC Transcriptional regulator HYU01_25445 ENOG41090T1 Membrane HYU01_25470 ENOG4105FAA peptidase M23 HYU01_25480 ENOG4105KZD Domain of unknown function (DUF1805) HYU01_25485 ENOG4107R8B 5'-nucleotidase HYU01_25505 ENOG4105DIW FeS assembly protein SUFB HYU01_25510 ENOG4108UNV SUF system FeS assembly protein, NifU family HYU01_25515 ENOG4105C9B Cysteine desulfurase HYU01_25520 ENOG4105JRK feS assembly protein SufD HYU01_25525 ENOG4105C3K feS assembly ATPase SufC HYU01_25530 ENOG4105D01 (LipO)protein HYU01_25535 ENOG4105D01 (LipO)protein HYU01_25540 ENOG4108UMI ABC transporter, permease HYU01_25575 ENOG41080E8 Transcriptional regulator, Spx MgsR family HYU01_25620 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HYU01_25650 ENOG4108W8B Beta-lactamase domain protein HYU01_25655 ENOG4105C1G acyl-Coa dehydrogenase HYU01_25665 ENOG4105CHU acetyl-coa acetyltransferase HYU01_25680 ENOG4105DZ1 carboxypeptidase HYU01_25700 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HYU01_25720 ENOG4108SUT Major Facilitator Superfamily HYU01_25725 ENOG4107R7I amino acid HYU01_25735 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HYU01_25745 ENOG4107AYK membrAne HYU01_25780 ENOG4107ZTW SNARE associated Golgi HYU01_25790 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HYU01_25795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_25800 ENOG4105BZU Histidine kinase HYU01_25810 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HYU01_25825 ENOG4105VG1 fes assembly suf system protein HYU01_25830 ENOG4105D4Y metalloprotease HYU01_25855 ENOG4107S91 Sodium hydrogen exchanger HYU01_25860 ENOG4105NCW Trka-c domain protein HYU01_25875 ENOG4108RMU ferritin dps family protein HYU01_25890 ENOG4108URH decarboxylase HYU01_25915 ENOG4105D9N nucleoside HYU01_25920 ENOG4105D9N nucleoside HYU01_25935 ENOG4108RYK Nad-dependent epimerase dehydratase HYU01_25950 ENOG4105CV8 reductase HYU01_25955 ENOG4105F27 Major Facilitator HYU01_25960 ENOG4105KVH Transcriptional regulator HYU01_25975 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HYU01_25980 ENOG4105D4A Cell wall formation (By similarity) HYU01_25990 ENOG4105C8Q Methyl-accepting chemotaxis HYU01_26000 ENOG4105WMR Protein CrcB homolog HYU01_26005 ENOG4105WMR Protein CrcB homolog HYU01_26020 ENOG4108MK9 spermidine N(1)-acetyltransferase HYU01_26025 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HYU01_26040 ENOG4108IPW abc transporter atp-binding protein HYU01_26045 ENOG4105CM4 permease protein HYU01_26070 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HYU01_26080 ENOG4105XZU Preprotein translocase, subunit SecG HYU01_26085 ENOG41067MG lrgb family HYU01_26180 ENOG4105EFC phage portal protein HK97 family HYU01_26200 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYU01_26210 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYU01_26215 ENOG4105CP7 Triose-phosphate isomerase HYU01_26240 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_26265 ENOG41090VF Stage v sporulation protein ac HYU01_26270 ENOG4105CZ3 stage V sporulation protein ad HYU01_26285 ENOG4105H67 Protein of unknown function (DUF421) HYU01_26290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYU01_26295 ENOG4105KRI phosphocarrier protein (HPr HYU01_26305 ENOG4105CHW UPF0052 protein HYU01_26315 ENOG4108Z4K mutator MutT protein HYU01_26325 ENOG4105C3M thioredoxin reductase HYU01_26335 ENOG4108S4C acetyltransferase HYU01_26355 ENOG41086DT Membrane protein of unknown function HYU01_26365 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HYU01_26370 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HYU01_26375 ENOG4105D7V transposase HYU01_26390 ENOG4107TXC Transcriptional regulator HYU01_26415 ENOG4105HMI Membrane HYU01_26420 ENOG4105DUM transcriptional regulator, lysR family HYU01_26430 ENOG4108WS4 fmn reductase HYU01_26445 ENOG4105BZ1 (ABC) transporter HYU01_26455 ENOG4105CN1 protease HYU01_26460 ENOG4105CRP Part of the ABC transporter FtsEX involved in HYU01_26465 ENOG4105CAK Cell division ATP-binding protein ftsE HYU01_26475 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HYU01_26485 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HYU01_26490 ENOG4105MS2 ribosomal subunit Interface protein HYU01_26495 ENOG4105VEQ Cold shock protein HYU01_26500 ENOG41081UC Inherit from COG: Competence protein HYU01_26515 ENOG4105KVH Transcriptional regulator HYU01_26525 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HYU01_26530 ENOG4108KGH TRANSCRIPTIONal HYU01_26535 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HYU01_26540 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYU01_26545 ENOG4105ESV Glycosyl transferase, family 4 HYU01_26555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HYU01_26570 ENOG410901P UPF0249 protein HYU01_26575 ENOG4105F8D glycoside hydrolase family 4 HYU01_26580 ENOG4105VCP PTS System HYU01_26585 ENOG4105CK1 PTS System HYU01_26595 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HYU01_26600 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HYU01_26605 ENOG4105VCP PTS System HYU01_26615 ENOG4105VZJ PTS System HYU01_26630 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HYU01_26635 ENOG4105ECB domain protein HYU01_26640 ENOG4107RSM transcriptional regulator HYU01_26685 ENOG4105DAA L-lactate HYU01_26695 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HYU01_26705 ENOG4105E0M Sulfatase HYU01_26735 ENOG4107R8N Glycosyl transferase, family 2 HYU01_26745 ENOG4105C94 Transporter HYU01_26750 ENOG41069ER domain protein HYU01_26775 ENOG4105KBK Zinc finger, swim domain protein HYU01_26780 ENOG4105C0D helicase HYU01_26815 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYU01_26825 ENOG4107RBB ABC transporter, permease HYU01_26830 ENOG4105C19 ABC transporter HYU01_26850 ENOG4105CXY transporter HYU01_26865 ENOG4105BZU Histidine kinase HYU01_26870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_26875 ENOG4105CMR udp-glucose 4-epimerase HYU01_26900 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HYU01_26905 ENOG4105EY8 ABC transporter HYU01_26955 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HYU01_26970 ENOG4105FRN stage II sporulation protein HYU01_26985 ENOG4105DY9 regulatoR HYU01_26990 ENOG4108IUW ABC transporter HYU01_27010 ENOG4106778 Protein of unknown function (DUF1146) HYU01_27015 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYU01_27020 ENOG4105C8S subunit m HYU01_27025 ENOG4105D65 subunit l HYU01_27050 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HYU01_27055 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HYU01_27065 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HYU01_27070 ENOG4105BZU Histidine kinase HYU01_27120 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HYU01_27125 ENOG41062M3 atp synthase HYU01_27155 ENOG4108YZG isomerase HYU01_27170 ENOG4108VGI doxx family HYU01_27175 ENOG4107XC4 flavin reductase domain protein, FMN-binding HYU01_27195 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HYU01_27205 ENOG4108ZXQ stage ii sporulation protein r HYU01_27210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYU01_27215 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HYU01_27235 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HYU01_27240 ENOG4105CBT Fructose-1,6-bisphosphatase HYU01_27245 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HYU01_27280 ENOG4105C1G acyl-Coa dehydrogenase HYU01_27285 ENOG4105C1G acyl-Coa dehydrogenase HYU01_27290 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYU01_27300 ENOG4105DF6 Fe-S oxidoreductase HYU01_27315 ENOG4105BZU Histidine kinase HYU01_27335 ENOG4105BZU Histidine kinase HYU01_27340 ENOG4105KCT ABC transporter HYU01_27345 ENOG4108M15 ABC transporter HYU01_27350 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HYU01_27365 ENOG4105IIU Aminopeptidase HYU01_27385 ENOG4105EMN RNA polymerase sigma factor HYU01_27395 ENOG410684U Domain of unknown function (DUF1934) HYU01_27420 ENOG4105CYW agmatinase HYU01_27430 ENOG4105DXB Major Facilitator superfamily HYU01_27435 ENOG4107SWG transcriptional regulator MERR family HYU01_27440 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HYU01_27445 ENOG4105BZ4 penicillin-binding protein HYU01_27450 ENOG4108XFG YwhD family HYU01_27455 ENOG4108Z4T Peptidase M50 HYU01_27460 ENOG41069HH 4-oxalocrotonate tautomerase HYU01_27465 ENOG4105DCI Phosphohydrolase HYU01_27470 ENOG4108MES Periplasmic binding protein HYU01_27475 ENOG4105E0A ABC, transporter HYU01_27480 ENOG4105EHG Permease protein HYU01_27485 ENOG4105DQ5 transport system permease protein HYU01_27495 ENOG4108VCI transcription factor, rsfa family HYU01_27510 ENOG4108IJ2 phosphate acetyltransferase HYU01_27525 ENOG4108VKI Cell wall hydrolase HYU01_27545 ENOG4107SVH Potassium channel protein HYU01_27555 ENOG410667J hydrolase HYU01_27560 ENOG4105VCH membrane HYU01_27570 ENOG4108TU7 Inherit from COG: (ABC) transporter HYU01_27575 ENOG4105CJ1 ABC, transporter HYU01_27580 ENOG41090WU lipolytic protein G-D-S-L family HYU01_27595 ENOG4105D6E homoserine dehydrogenase HYU01_27620 ENOG4108Y4K DNA-binding transcriptional activator HYU01_27635 ENOG4105WH1 Two component transcriptional regulator luxr family HYU01_27645 ENOG4105DWF phosphomethylpyrimidine kinase HYU01_27650 ENOG4105BZU Histidine kinase HYU01_27655 ENOG4105VCD cytoplasmic protein HYU01_27660 ENOG4105D22 carbon starvation protein HYU01_27665 ENOG4105DY9 regulatoR HYU01_27670 ENOG41079KZ Major Facilitator Superfamily HYU01_27690 ENOG4105EN6 Membrane HYU01_27695 ENOG4106YBV Methyl-accepting chemotaxis HYU01_27705 ENOG4108S4H thioesterase Superfamily protein HYU01_27715 ENOG4105JEU Glycosyl transferase, family 2 HYU01_27720 ENOG4105C5H ABC transporter HYU01_27745 ENOG4105CKK Glycosyl transferase, family 2 HYU01_27750 ENOG41067SE Tetr family transcriptional regulator HYU01_27760 ENOG4105E0X reductase HYU01_27765 ENOG4106F5Q Membrane HYU01_27780 ENOG4105DY9 regulatoR HYU01_27785 ENOG4108HRK Histidine kinase HYU01_27790 ENOG4107RGD Major Facilitator superfamily HYU01_27805 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYU01_27815 ENOG4105IW1 AmiS UreI transporter HYU01_27825 ENOG4105CMR udp-glucose 4-epimerase HYU01_27830 ENOG4108UT2 hemolysin iii HYU01_27840 ENOG4105C1J atp-dependent rna helicase HYU01_27855 ENOG4105DPN Oligoendopeptidase f HYU01_27875 ENOG4105C0H protease HYU01_27880 ENOG4105Q2H domain protein HYU01_27895 ENOG4105BZU Histidine kinase HYU01_27900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYU01_27930 ENOG4105CDU Replicative dna helicase HYU01_27940 ENOG4105BZR domain protein HYU01_27945 ENOG4108XMW Membrane HYU01_27955 ENOG4108UUM single-stranded DNA-binding protein HYU01_27965 ENOG4105C3G gtp-binding protein HYU01_27970 ENOG4105VDK protein, conserved in bacteria HYU01_27975 ENOG4105D8X mechanosensitive ion channel HYU01_27980 ENOG4108ZDA Sporulation protein YyaC HYU01_27985 ENOG4105FA0 parb-like partition protein HYU01_27990 ENOG4107QJE Chromosome Partitioning Protein HYU01_28010 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HYU01_28020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HYU01_28085 ENOG4105EKQ RNA-directed DNA polymerase HYU01_28185 ENOG4105EKQ RNA-directed DNA polymerase HYU01_28245 ENOG4106JUT Streptomycin 3''-adenylyltransferase HYU01_28310 ENOG4105CNU cell division protein FtsK HYU01_28550 ENOG4105DHF Membrane HYU01_28580 ENOG4106AKK s-layer domain-containing protein HYU01_28585 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HYU01_28610 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HYU01_28615 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYU01_28635 ENOG4105DQ6 Transposase HYU01_28675 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HYU01_28830 ENOG4105KRN Transcriptional regulator, abrb family HYU01_28840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYU01_28875 ENOG4108IBT Inherit from COG: transposase HYU01_28885 ENOG4105DQ6 Transposase HYU01_28910 ENOG4108MEK Metal-binding protein YodA HYU01_28920 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HYU01_28955 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HYU01_29200 ENOG4107QJE Chromosome Partitioning Protein HYU01_29220 ENOG4105DQ6 Transposase HYU01_29250 ENOG4105EWC Purine nucleoside phosphorylase HYU01_29340 ENOG4105C3F Signal peptidase i HYU01_29370 ENOG4105N14 lysine exporter protein LysE YggA HYU01_29405 ENOG4108J59 Extracellular solute-binding protein, family 5 HYU01_29425 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)