locus-tag class description DY471_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DY471_00015 ENOG410848D S4 domain protein YaaA DY471_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY471_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DY471_00100 ENOG4105ZMH deoxynucleoside kinase DY471_00110 ENOG4105GTG Isochorismatase DY471_00115 ENOG4108Z6B deaminase DY471_00125 ENOG4105C6E dna polymerase iii DY471_00145 ENOG41067KS pro-sigma K processing DY471_00180 ENOG4105CXN decarboxylase DY471_00190 ENOG4105FA2 dna polymerase iii DY471_00195 ENOG4105MA4 psp1 domain protein DY471_00205 ENOG41060K3 Methyltransferase DY471_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DY471_00220 ENOG4105KRN Transcriptional regulator, abrb family DY471_00230 ENOG4105F8V Hydrolase, tatD family DY471_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DY471_00245 ENOG4105XFA sporulation peptidase YabG DY471_00250 ENOG4105W42 Veg protein DY471_00265 ENOG4105DFT pur operon repressor DY471_00270 ENOG4105KME endoribonuclease L-psp DY471_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DY471_00300 ENOG4108JA2 transcriptioN-repair coupling factor DY471_00305 ENOG4108M14 stage v sporulation protein t DY471_00315 ENOG4108IY2 MazG family DY471_00320 ENOG41082I2 s4 domain protein DY471_00325 ENOG4105VYY sporulation protein yabp DY471_00340 ENOG41060GV RNA binding s1 domain protein DY471_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase DY471_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DY471_00385 ENOG4105C6T cysteine synthase DY471_00390 ENOG4105CRQ synthase (Component I) DY471_00395 ENOG4105DDQ anthranilate synthase DY471_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DY471_00405 ENOG4105EEI dihydropteroate synthase DY471_00410 ENOG4105KRF dihydroneopterin aldolase DY471_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DY471_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DY471_00515 ENOG4108Z0C Uvrb UvrC protein DY471_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DY471_00540 ENOG4105CTP PilT protein domain protein DY471_00560 ENOG4105D7W serine acetyltransferase DY471_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 DY471_00580 ENOG4105M0M Tetracycline resistance protein DY471_00585 ENOG4105QIV RNA polymerase DY471_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DY471_00625 ENOG4107Y49 methyltransferase DY471_00640 ENOG4105XPM ribosomal protein DY471_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DY471_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DY471_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DY471_00790 ENOG41067V7 50S ribosomal protein L36 DY471_00820 ENOG4108JJB ABC transporter DY471_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DY471_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DY471_00855 ENOG4105D1F ATP-binding protein DY471_00870 ENOG4108NMV polysaccharide deacetylase DY471_00950 ENOG4105C8B TIGR00159 family DY471_00955 ENOG4107U5W ybbr family DY471_01000 ENOG4108VQT Alpha beta hydrolase fold protein DY471_01010 ENOG4105CMG Carbohydrate kinase DY471_01020 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DY471_01025 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DY471_01055 ENOG4108PSK reductase DY471_01060 ENOG4108UMI ABC transporter, permease DY471_01070 ENOG4105D01 (LipO)protein DY471_01075 ENOG4105EE1 crotonyl-CoA reductase DY471_01085 ENOG4105IQ5 FAD linked oxidase domain protein DY471_01100 ENOG4105C2C drug resistance transporter, Bcr CflA DY471_01115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY471_01120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY471_01125 ENOG4105C3U ABC transporter DY471_01130 ENOG4108JQ7 (ABC) transporter DY471_01155 ENOG4105U5Y Transcriptional regulator DY471_01165 ENOG4108J59 Extracellular solute-binding protein, family 5 DY471_01170 ENOG4108J59 Extracellular solute-binding protein, family 5 DY471_01180 ENOG4105II7 pyrroline-5-carboxylate reductase DY471_01185 ENOG4107XDY Nicotinamide Mononucleotide Transporter DY471_01195 ENOG4105E0C molybdate abc transporter DY471_01200 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DY471_01205 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DY471_01235 ENOG4105F6E Acyl-transferase DY471_01255 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DY471_01275 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DY471_01295 ENOG4105C5H ABC transporter DY471_01300 ENOG4105BZU Histidine kinase DY471_01305 ENOG4105WH1 Two component transcriptional regulator luxr family DY471_01310 ENOG4105CJ1 ABC, transporter DY471_01315 ENOG41090VJ ABC-2 type transporter DY471_01320 ENOG4108KYE ABC-2 type transporter DY471_01330 ENOG4105DEF Extracellular solute-binding protein, family 5 DY471_01340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY471_01345 ENOG4105C3U ABC transporter DY471_01350 ENOG4108JQ7 (ABC) transporter DY471_01355 ENOG410667J hydrolase DY471_01385 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DY471_01390 ENOG4105ERH Fumarylacetoacetate hydrolase DY471_01400 ENOG4105CUB amino acid DY471_01410 ENOG4105CPF Cell wall formation (By similarity) DY471_01415 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DY471_01440 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DY471_01445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DY471_01455 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DY471_01555 ENOG4105K8N protein family UPF0079, ATPase DY471_01560 ENOG41072GX Peptidase M22 Glycoprotease DY471_01565 ENOG410801F ribosomal-protein-alanine acetyltransferase DY471_01570 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DY471_01575 ENOG4105C5H ABC transporter DY471_01590 ENOG4108TYN CAAX amino terminal protease family protein DY471_01625 ENOG4107QZI cell division protein FtsK DY471_01635 ENOG4106128 DNA-binding helix-turn-helix protein DY471_01650 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DY471_01660 ENOG4105C7N Xanthine uracil vitamin C permease DY471_01670 ENOG4105BZU Histidine kinase DY471_01695 ENOG4107ZXU DSBA oxidoreductase DY471_01775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_01795 ENOG4105SX7 Transporter DY471_01825 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DY471_01830 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DY471_01835 ENOG4105C83 adenylosuccinate lyase DY471_01845 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DY471_01870 ENOG4108V3E phosphoribosylglycinamide formyltransferase DY471_01880 ENOG4105C12 Phosphoribosylglycinamide synthetase DY471_01910 ENOG4105C4R Atp-dependent dna helicase DY471_01935 ENOG4108W2Y isochorismatase DY471_01950 ENOG4108UMI ABC transporter, permease DY471_01955 ENOG4105D01 (LipO)protein DY471_01975 ENOG410834F Transcriptional regulator DY471_01980 ENOG4107I77 yiaA/B two helix domain DY471_02000 ENOG4105CBD Diacylglycerol kinase DY471_02005 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DY471_02010 ENOG4108JPW Aminotransferase DY471_02020 ENOG4105C26 Dehydrogenase DY471_02025 ENOG4105KPY Small multidrug resistance protein DY471_02045 ENOG4105D9N nucleoside DY471_02050 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DY471_02065 ENOG4105BZU Histidine kinase DY471_02070 ENOG4108W15 Protein of unknown function (DUF1456) DY471_02085 ENOG4105DTQ mandelate racemase muconate lactonizing DY471_02095 ENOG4105DFD Na H antiporter DY471_02115 ENOG4105D3R alkyl hydroperoxide reductase DY471_02120 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DY471_02130 ENOG4107W7X Aldolase DY471_02135 ENOG4105EHG Permease protein DY471_02140 ENOG4105DQ5 transport system permease protein DY471_02145 ENOG4108V5C ABC transporter DY471_02175 ENOG4106UIA DY471_02180 ENOG4106UIA DY471_02200 ENOG4105BZU Histidine kinase DY471_02220 ENOG410756H nucleotidyltransferase DY471_02225 ENOG4105D2S major facilitator superfamily DY471_02240 ENOG4105E5Q amino acid AbC transporter DY471_02245 ENOG4105EAB amino acid AbC transporter DY471_02255 ENOG4105C8Q Methyl-accepting chemotaxis DY471_02265 ENOG4105CI1 PTS System DY471_02300 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DY471_02315 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY471_02330 ENOG4105C5H ABC transporter DY471_02360 ENOG41062JF Transcriptional regulator DY471_02380 ENOG4105DEU major facilitator superfamily DY471_02415 ENOG4108N0M stress protein DY471_02420 ENOG4106FN3 tellurium resistance protein DY471_02425 ENOG4106FN3 tellurium resistance protein DY471_02430 ENOG4107TS3 membrane protein, TerC DY471_02435 ENOG4108TTB tellurium resistance protein DY471_02455 ENOG4105KJF protein tyrosine phosphatase DY471_02465 ENOG4107U9T Pfam:Ribonuclease_BN DY471_02470 ENOG4105C59 p-type ATPase DY471_02475 ENOG4108IPJ Membrane DY471_02485 ENOG4105D7V transposase DY471_02495 ENOG4105C3F Signal peptidase i DY471_02505 ENOG4107ZTW SNARE associated Golgi DY471_02520 ENOG410606W general stress protein DY471_02525 ENOG4105UPD Calcium Proton DY471_02565 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DY471_02575 ENOG4108JUB Transcriptional regulator DY471_02585 ENOG4108IQI permease DY471_02610 ENOG4105CSV Glutaminase DY471_02625 ENOG4108A04 Beta-lactamase DY471_02645 ENOG4105CKK Glycosyl transferase, family 2 DY471_02650 ENOG4107QQG Dehydrogenase DY471_02670 ENOG4105F1A Pyruvate formate-lyase DY471_02690 ENOG4105CI2 imidazolone-5-propionate hydrolase DY471_02695 ENOG4105ECP epimerase DY471_02725 ENOG41067AE Membrane-bound metal-dependent hydrolase DY471_02730 ENOG4105CEN a g-specific adenine glycosylase DY471_02735 ENOG4106BXE DY471_02755 ENOG4105BZ1 (ABC) transporter DY471_02760 ENOG4107NBY Membrane DY471_02765 ENOG4105CBC glutamate synthase DY471_02775 ENOG4108IUW ABC transporter DY471_02795 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DY471_02800 ENOG4105G5W regulator Fur family DY471_02915 ENOG4108JQC penicillin-binding protein 1A DY471_02920 ENOG4107ZQN disulfide bond DY471_02930 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DY471_02940 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DY471_02945 ENOG4105BZU Histidine kinase DY471_02950 ENOG4105CYN Serine protein kinase DY471_02970 ENOG4105C94 Transporter DY471_02985 ENOG4105DZ6 Band 7 protein DY471_02995 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DY471_03000 ENOG4108V9W transcriptional regulatory protein DY471_03005 ENOG4105D4T Citrate transporter DY471_03030 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DY471_03035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY471_03040 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DY471_03045 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DY471_03050 ENOG4105BZ7 extracellular solute-binding protein family 1 DY471_03055 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DY471_03060 ENOG4108STX response regulator DY471_03065 ENOG4105US7 Histidine kinase DY471_03090 ENOG4108MRH transcriptional regulatory protein DY471_03100 ENOG4105C6K Malic enzyme DY471_03110 ENOG4108UZ3 Transporter DY471_03115 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY471_03125 ENOG4105BZU Histidine kinase DY471_03130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_03135 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DY471_03140 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DY471_03145 ENOG4108JB9 formate dehydrogenase DY471_03165 ENOG4105CUB amino acid DY471_03175 ENOG4105C59 p-type ATPase DY471_03180 ENOG4105DAP Nicotinate phosphoribosyltransferase DY471_03210 ENOG41073R8 VanW family DY471_03215 ENOG4108KGH TRANSCRIPTIONal DY471_03220 ENOG4105D9N nucleoside DY471_03225 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DY471_03230 ENOG4105C37 (CBS) domain DY471_03235 ENOG4108IJ0 Aspartate ammonia-lyase DY471_03240 ENOG4105DAA L-lactate DY471_03255 ENOG4105DUX Transporter DY471_03260 ENOG4108MES Periplasmic binding protein DY471_03265 ENOG4105DQ5 transport system permease protein DY471_03270 ENOG4108IHU transport system permease protein DY471_03275 ENOG4105E0A ABC, transporter DY471_03280 ENOG4105DMQ Methyltransferase DY471_03290 ENOG4105EXW epimerase dehydratase DY471_03295 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DY471_03305 ENOG4107T89 von Willebrand factor, type A DY471_03310 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DY471_03315 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY471_03330 ENOG4105BZU Histidine kinase DY471_03335 ENOG4105D5Q Arginine ornithine antiporter DY471_03340 ENOG4107414 GntR family transcriptional regulator DY471_03345 ENOG4105C5Y PTS System DY471_03350 ENOG4105CG3 alpha amylase, catalytic region DY471_03365 ENOG4105E1K spore germination protein DY471_03375 ENOG4105CRN Aminoglycoside phosphotransferase DY471_03380 ENOG4105BZG amino acid carrier protein DY471_03385 ENOG4105CDA abc transporter atp-binding protein DY471_03390 ENOG4105CT1 (ABC) transporter DY471_03395 ENOG4105EAD ABC transporter DY471_03400 ENOG4105DRP amino acid AbC transporter DY471_03405 ENOG4108IQI permease DY471_03430 ENOG4105D29 Helix-turn-helix type 11 domain protein DY471_03435 ENOG4105NAE bifunctional deaminase-reductase domain protein DY471_03440 ENOG4105BZU Histidine kinase DY471_03455 ENOG4105CHH sulfate transporter DY471_03460 ENOG41068KF Universal stress protein DY471_03470 ENOG4105DEF Extracellular solute-binding protein, family 5 DY471_03480 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY471_03485 ENOG4108JQ7 (ABC) transporter DY471_03495 ENOG4105CXY transporter DY471_03500 ENOG41067TZ transcriptional regulator, MarR family DY471_03505 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_03510 ENOG4105ETE Transcriptional regulator (LacI family DY471_03515 ENOG4108RVA ribokinase DY471_03525 ENOG4105C2J ABC transporter DY471_03530 ENOG4105CNN ABC, transporter DY471_03535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DY471_03540 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DY471_03550 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DY471_03605 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY471_03610 ENOG41069ER domain protein DY471_03615 ENOG4105VZ8 Transcriptional regulator DY471_03620 ENOG4107D63 DY471_03630 ENOG4105DUX Transporter DY471_03650 ENOG4105C85 amino acid DY471_03655 ENOG4105C7N Xanthine uracil vitamin C permease DY471_03670 ENOG4105MA6 gCN5-related N-acetyltransferase DY471_03695 ENOG4105BZ9 Cytochrome C oxidase, subunit I DY471_03700 ENOG4105E2S oxidase) subunit II DY471_03705 ENOG4108IQI permease DY471_03720 ENOG4106CAD Protein of unknown function (DUF3311) DY471_03725 ENOG4105E1V na solute symporter DY471_03740 ENOG4108NHD germination protein DY471_03745 ENOG4105CE1 Ferrous iron transport protein b DY471_03750 ENOG4105CE1 Ferrous iron transport protein b DY471_03755 ENOG4105CE1 Ferrous iron transport protein b DY471_03760 ENOG4105CVA phosphate DY471_03765 ENOG4105C8U phosphate abc transporter DY471_03770 ENOG4105E2Z phosphate ABC transporter (Permease DY471_03900 ENOG41080XQ Signal transduction protein with cbs domains DY471_03920 ENOG4105ETU transcriptional activator (TenA DY471_03930 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY471_03940 ENOG4108VEU Thiamine monophosphate synthase DY471_03945 ENOG41080HI glycine oxidase DY471_03960 ENOG4105D06 uba thif-type nad fad binding protein DY471_03965 ENOG4105DWF phosphomethylpyrimidine kinase DY471_04015 ENOG4108INS Transcriptional regulator DY471_04030 ENOG4105C7N Xanthine uracil vitamin C permease DY471_04040 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DY471_04075 ENOG4108B31 Spore germination protein DY471_04095 ENOG4107Y03 Nitroreductase DY471_04100 ENOG4105ED1 spovr family DY471_04105 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 DY471_04115 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DY471_04120 ENOG4105XTG Pfam:DUF156 DY471_04125 ENOG4105VFE sira family DY471_04130 ENOG4107TPS domain protein DY471_04135 ENOG4105VFE sira family DY471_04140 ENOG4105VFE sira family DY471_04150 ENOG41085GJ domain protein DY471_04160 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DY471_04165 ENOG41087NI Sulfite exporter TauE/SafE DY471_04175 ENOG4108KGH TRANSCRIPTIONal DY471_04205 ENOG4105EMD TRANSCRIPTIONal DY471_04210 ENOG4105VCP PTS System DY471_04215 ENOG4105VZJ PTS System DY471_04235 ENOG41069ER domain protein DY471_04240 ENOG4107RBB ABC transporter, permease DY471_04245 ENOG4105C19 ABC transporter DY471_04275 ENOG4105WEF catalase DY471_04310 ENOG4107T5V SNARE associated Golgi DY471_04340 ENOG4105CUB amino acid DY471_04345 ENOG4107RWR Sodium hydrogen exchanger DY471_04355 ENOG4106KNT transcriptional regulator DY471_04390 ENOG4108PCN EamA-like transporter family DY471_04395 ENOG4108YXU transcriptional regulator AsnC family DY471_04405 ENOG4108IXY short-chain dehydrogenase reductase DY471_04415 ENOG4105KPY Small multidrug resistance protein DY471_04420 ENOG4105KPY Small multidrug resistance protein DY471_04445 ENOG4105NF4 modulator of drug activity DY471_04455 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DY471_04460 ENOG4105E5W Transporter DY471_04470 ENOG4107RKG DJ-1/PfpI family DY471_04475 ENOG4105CH6 catalase DY471_04485 ENOG4105D5Q Arginine ornithine antiporter DY471_04490 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DY471_04500 ENOG4105C26 Dehydrogenase DY471_04515 ENOG4105BZ1 (ABC) transporter DY471_04520 ENOG4105BZ1 (ABC) transporter DY471_04535 ENOG4105DRP amino acid AbC transporter DY471_04540 ENOG4105CDA abc transporter atp-binding protein DY471_04555 ENOG410839P DY471_04590 ENOG4107FQX Alpha-acetolactate decarboxylase DY471_04615 ENOG4105D4P Coproporphyrinogen iii oxidase DY471_04635 ENOG4105CHH sulfate transporter DY471_04645 ENOG4105CGU Enoyl-CoA hydratase DY471_04660 ENOG4105DER m42 family DY471_04680 ENOG4105CTU Proline racemase DY471_04710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY471_04720 ENOG4108JQ7 (ABC) transporter DY471_04730 ENOG410780I phosphoprotein phosphatase activity DY471_04750 ENOG4105CSH Transporter DY471_04760 ENOG4108MRH transcriptional regulatory protein DY471_04805 ENOG4105DZR Type I site-specific deoxyribonuclease DY471_04835 ENOG4105CDU Replicative dna helicase DY471_04860 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_04910 ENOG4107P5I polyketide synthase DY471_04915 ENOG4108IG5 Transcriptional regulator DY471_04925 ENOG4105CID antiterminator DY471_04930 ENOG4105C5Y PTS System DY471_04935 ENOG4105CS2 ec 3.2.1.21 DY471_04945 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DY471_04985 ENOG4105CMT Dihydroxyacetone kinase DY471_05000 ENOG4105CMT Dihydroxyacetone kinase DY471_05045 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DY471_05105 ENOG4105C19 ABC transporter DY471_05115 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DY471_05150 ENOG4105WN5 stage II sporulation protein DY471_05160 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_05170 ENOG4108MJI response regulator DY471_05175 ENOG4105BZU Histidine kinase DY471_05180 ENOG4105BZU Histidine kinase DY471_05200 ENOG4105K8R UPF0145 protein DY471_05215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_05260 ENOG4107VRP DNA repair exonuclease DY471_05265 ENOG4106D4I domain protein DY471_05320 ENOG4108MUZ hydrolase DY471_05345 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DY471_05360 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DY471_05365 ENOG4105EMN RNA polymerase sigma factor DY471_05375 ENOG4105CNI cell division protein FtsW DY471_05390 ENOG4105C57 major facilitator superfamily DY471_05395 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_05405 ENOG4105EEM helicase DY471_05410 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY471_05435 ENOG4105K59 histidine triad (HIT) protein DY471_05520 ENOG410905X membrane-flanked domain protein DY471_05525 ENOG4105CKV Membrane DY471_05545 ENOG410905X membrane-flanked domain protein DY471_05550 ENOG4105CKV Membrane DY471_05555 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DY471_05560 ENOG4105BZ4 penicillin-binding protein DY471_05575 ENOG4105C1Q protoporphyrinogen oxidase DY471_05600 ENOG4105NA0 Transcriptional regulator DY471_05615 ENOG4105ECB domain protein DY471_05630 ENOG4108MK9 spermidine N(1)-acetyltransferase DY471_05640 ENOG4105D29 Helix-turn-helix type 11 domain protein DY471_05655 ENOG4106AXD DY471_05660 ENOG4108RQ5 Beta-lactamase domain-containing protein DY471_05665 ENOG4105DF9 Lipoate-protein, ligase DY471_05675 ENOG4105CEY Amp-dependent synthetase and ligase DY471_05690 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DY471_05695 ENOG4107RN3 metallophosphoesterase DY471_05705 ENOG4107TVP HD domain protein DY471_05710 ENOG4107YPT transcriptional regulator DY471_05715 ENOG4105C57 major facilitator superfamily DY471_05725 ENOG4108AEY RNA polymerase sigma factor DY471_05735 ENOG41086D8 Transcriptional regulator DY471_05750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_05775 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DY471_05780 ENOG4105C8Q Methyl-accepting chemotaxis DY471_05795 ENOG4107QP3 malate synthase g DY471_05810 ENOG4105VEQ Cold shock protein DY471_05825 ENOG4105XVF Competence transcription factor DY471_05890 ENOG4105ERH Fumarylacetoacetate hydrolase DY471_05915 ENOG4105CAQ asparagine synthetase DY471_05925 ENOG4105CH6 catalase DY471_05930 ENOG4105BZU Histidine kinase DY471_05955 ENOG4105QNR S1 RNA binding domain protein DY471_05960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY471_05970 ENOG4107AYK membrAne DY471_05975 ENOG41073B9 DY471_05985 ENOG4108KP7 hydrolase DY471_05995 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DY471_06020 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY471_06025 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DY471_06045 ENOG4105C31 Tryptophanyl-tRNA synthetase DY471_06065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY471_06070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY471_06080 ENOG4108JQ7 (ABC) transporter DY471_06085 ENOG4105UQX Mate efflux family protein DY471_06105 ENOG4108ZCF integral membrane protein DY471_06115 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY471_06125 ENOG4105DPN Oligoendopeptidase f DY471_06135 ENOG4108Z18 K06886 hemoglobin DY471_06140 ENOG4105MIX Adenylate cyclase DY471_06155 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DY471_06160 ENOG4105EMS pseudouridine synthase DY471_06180 ENOG4105K64 Glycosyl transferase, family 2 DY471_06200 ENOG4107TVC Glycosyl transferase, family 2 DY471_06220 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DY471_06225 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DY471_06235 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DY471_06310 ENOG4105CK7 Sodium proline symporter DY471_06320 ENOG4105CRQ synthase (Component I) DY471_06325 ENOG4105DDQ anthranilate synthase DY471_06425 ENOG4105C7S Dehydrogenase DY471_06435 ENOG4105VZ8 Transcriptional regulator DY471_06500 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DY471_06510 ENOG4105DZ1 carboxypeptidase DY471_06515 ENOG4105VFR signal peptidase DY471_06550 ENOG4105C26 Dehydrogenase DY471_06560 ENOG4105F38 ABC transporter, permease DY471_06565 ENOG4105D38 putrescine abc transporter DY471_06570 ENOG4107RUE extracellular solute-binding protein family 1 DY471_06580 ENOG4105EYF MMPL domain protein DY471_06590 ENOG4108YBP pseudouridine synthase DY471_06600 ENOG4105K4I Scp-like extracellular DY471_06605 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DY471_06610 ENOG4105CQB FAD linked oxidase domain protein DY471_06625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_06630 ENOG4105BZU Histidine kinase DY471_06635 ENOG4105JXH GntR family transcriptional regulator DY471_06655 ENOG4106A3R peptidase DY471_06665 ENOG4108QTI )-transporter DY471_06670 ENOG4107TS3 membrane protein, TerC DY471_06675 ENOG4105CZN Potassium uptake protein DY471_06680 ENOG410681C small acid-soluble spore protein DY471_06685 ENOG4108Z7G MaoC domain protein dehydratase DY471_06705 ENOG4105CHR reductase DY471_06735 ENOG4105C4Y ABC transporter DY471_06740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY471_06745 ENOG4107RCV ABC transporter, permease DY471_06765 ENOG4105E98 transcriptional regulator DeoR family DY471_06780 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DY471_06790 ENOG4105PXI polysaccharide deacetylase DY471_06800 ENOG4105BZU Histidine kinase DY471_06805 ENOG41090MY MarR family Transcriptional regulator DY471_06815 ENOG4106DF1 DY471_06820 ENOG4105BZU Histidine kinase DY471_06830 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DY471_06835 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DY471_06875 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DY471_06900 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DY471_06905 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DY471_06910 ENOG4105CZV ABC transporter DY471_06920 ENOG4105CJ1 ABC, transporter DY471_06960 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DY471_06965 ENOG4105EA8 2-Nitropropane dioxygenase DY471_06970 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DY471_06980 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DY471_07000 ENOG4105NQC Flavodoxin DY471_07030 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DY471_07060 ENOG4105CZN Potassium uptake protein DY471_07065 ENOG41063Y9 DY471_07070 ENOG4105KBJ sporulation protein ytfj DY471_07095 ENOG4105CM2 brancheD-chain amino acid aminotransferase DY471_07100 ENOG4105C7K acetolactate synthase DY471_07105 ENOG4108ZP8 Acetolactate synthase small subunit DY471_07180 ENOG4107RVV histidinol phosphate phosphatase, hisj family DY471_07195 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DY471_07200 ENOG4105E0M Sulfatase DY471_07210 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DY471_07230 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DY471_07235 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DY471_07245 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DY471_07250 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DY471_07260 ENOG4105C8J )-transporter DY471_07280 ENOG4105DFD Na H antiporter DY471_07300 ENOG4105ENE Histidine kinase DY471_07305 ENOG4105WH1 Two component transcriptional regulator luxr family DY471_07325 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DY471_07370 ENOG4105CJ3 phosphate transporter DY471_07375 ENOG4107GRR phosphate transport regulator DY471_07380 ENOG4105BZ4 penicillin-binding protein DY471_07395 ENOG4105BZU Histidine kinase DY471_07400 ENOG4105I3N Conserved Protein DY471_07415 ENOG4105BZU Histidine kinase DY471_07445 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY471_07450 ENOG4105DZ1 carboxypeptidase DY471_07455 ENOG4108JIC nucleoside recognition domain protein DY471_07465 ENOG4105FE9 pseudouridine synthase DY471_07475 ENOG4107TWT Cytochrome c biogenesis protein DY471_07480 ENOG4105CRE cytochrome C DY471_07485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_07490 ENOG4105BZU Histidine kinase DY471_07495 ENOG4108WBT adenosyltransferase DY471_07500 ENOG41063SB peptidase DY471_07510 ENOG4108SAX Membrane DY471_07525 ENOG4105C9U ATP-dependent DNA helicase RecQ DY471_07530 ENOG4105I7S Abortive infection protein DY471_07540 ENOG4107RGJ metallophosphoesterase DY471_07545 ENOG4107X2D transcriptional regulator, merr family DY471_07550 ENOG4108S6Z Negative regulator of genetic competence DY471_07575 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DY471_07580 ENOG4105HDK L-asparaginase DY471_07610 ENOG4105S2F DY471_07615 ENOG41065D1 DY471_07645 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DY471_07660 ENOG4105XXQ heptaprenyl diphosphate synthase component I DY471_07670 ENOG4105EAH synthase DY471_07695 ENOG41068YB TPR repeat-containing protein DY471_07710 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DY471_07715 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DY471_07720 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DY471_07750 ENOG4108JYZ YitT family DY471_07760 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DY471_07775 ENOG4105FJR Lmbe family DY471_07780 ENOG4105CPK Glycosyl transferase (Group 1 DY471_07815 ENOG4105DVT helicase DY471_07820 ENOG4105YAC DY471_07840 ENOG4105CSM endonuclease III DY471_07850 ENOG4105BZ4 penicillin-binding protein DY471_07905 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DY471_07915 ENOG4105DVT helicase DY471_07920 ENOG4105CTD carboxy-peptidase DY471_07935 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DY471_07945 ENOG4105C2W permease DY471_07950 ENOG4105DHF Membrane DY471_07955 ENOG410890F Dynamin family DY471_07965 ENOG4108W0I acetyltransferase DY471_07975 ENOG4105KHC sulfurtransferase DY471_08000 ENOG4106032 Glutathionylspermidine synthase DY471_08060 ENOG4105CPK Glycosyl transferase (Group 1 DY471_08095 ENOG41081VK Ribonuclease DY471_08160 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY471_08170 ENOG4107RWR Sodium hydrogen exchanger DY471_08175 ENOG4105CN5 Metallo-Beta-Lactamase DY471_08180 ENOG4108Z5V transcriptional regulator, merr family DY471_08190 ENOG4105H67 Protein of unknown function (DUF421) DY471_08195 ENOG41080C8 DUF218 domain DY471_08255 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DY471_08265 ENOG4107R0U MotA TolQ exbB proton channel DY471_08270 ENOG4105ER2 Ompa motb domain protein DY471_08275 ENOG4107YTP response regulator receiver protein DY471_08280 ENOG4105CBS Chea signal transduction histidine kinase DY471_08285 ENOG4105DD5 Flagellar motor switch protein DY471_08300 ENOG4105BZU Histidine kinase DY471_08320 ENOG4105E1Q flagellar hook-associated protein DY471_08325 ENOG4105DTJ flagellar hook-associated protein DY471_08345 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DY471_08350 ENOG4108ZC9 flagellar basal-body rod protein flgc DY471_08355 ENOG41075Z6 flagellar hook-basal body complex protein fliE DY471_08360 ENOG4107U2N Flagellar M-ring protein DY471_08365 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DY471_08395 ENOG4105BZE flagellar hook protein, FlgE DY471_08410 ENOG4107R88 Chemotaxis protein (CheV) DY471_08420 ENOG4105I03 Flagellin DY471_08425 ENOG4105I03 Flagellin DY471_08430 ENOG4105E4C Lytic transglycosylase catalytic DY471_08440 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DY471_08445 ENOG4105DD5 Flagellar motor switch protein DY471_08455 ENOG4105CN7 Flagellar biosynthetic protein FliP DY471_08460 ENOG4105VS8 Flagellar biosynthetic protein fliq DY471_08470 ENOG4105D00 flagellar biosynthetic protein flhB DY471_08475 ENOG4105D7B Flagellar biosynthesis protein flha DY471_08480 ENOG4105FZW flagellar biosynthesis regulator FlhF DY471_08485 ENOG4105KTQ flagellar basal-body rod protein DY471_08490 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY471_08525 ENOG4105KAC Antibiotic biosynthesis monooxygenase DY471_08550 ENOG4105DUM transcriptional regulator, lysR family DY471_08555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY471_08560 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DY471_08570 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DY471_08620 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DY471_08630 ENOG4105K56 Transcriptional regulator DY471_08640 ENOG4105CAQ asparagine synthetase DY471_08660 ENOG4105PGM cation diffusion facilitator family transporter DY471_08670 ENOG4105DRR Transcriptional regulator, GntR family DY471_08675 ENOG4108UZ3 Transporter DY471_08680 ENOG4105CKI cobalamin synthesis protein DY471_08700 ENOG4105DFD Na H antiporter DY471_08705 ENOG4105C9Q fumarate hydratase class II DY471_08725 ENOG4107QJQ Mate efflux family protein DY471_08730 ENOG4105EC3 peptidase S51, dipeptidase E DY471_08750 ENOG4107QIV Cytochrome c biogenesis protein DY471_08775 ENOG4106BRA Membrane DY471_08815 ENOG4105CJ1 ABC, transporter DY471_08835 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DY471_08845 ENOG4108IJ0 Aspartate ammonia-lyase DY471_08850 ENOG4105C6K Malic enzyme DY471_08885 ENOG41067QW Transcriptional regulator DY471_08915 ENOG4105FVX DY471_08945 ENOG4105CSR polyphosphate kinase 2 DY471_08950 ENOG4105DXI Major Facilitator superfamily DY471_08965 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DY471_08975 ENOG4105EU0 Major facilitator Superfamily DY471_08980 ENOG4105C6T cysteine synthase DY471_09000 ENOG4105C8J )-transporter DY471_09010 ENOG4105X5K response regulator receiver protein DY471_09015 ENOG4105H67 Protein of unknown function (DUF421) DY471_09030 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DY471_09035 ENOG4105CHR reductase DY471_09040 ENOG4105CM2 brancheD-chain amino acid aminotransferase DY471_09045 ENOG4105C7K acetolactate synthase DY471_09055 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DY471_09065 ENOG4105C7B Threonine dehydratase DY471_09090 ENOG4105C6X Major Facilitator DY471_09095 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DY471_09105 ENOG4105DY9 regulatoR DY471_09110 ENOG4105CYC Transferase DY471_09130 ENOG4105F6J Alpha beta hydrolase fold DY471_09175 ENOG41068WN DY471_09205 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DY471_09210 ENOG4105C72 UPF0176 protein DY471_09220 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DY471_09225 ENOG4105C0X amino acid DY471_09260 ENOG4105KKX ATPase associated with various cellular activities aaa_5 DY471_09270 ENOG4105DEG Vwa containing coxe family protein DY471_09295 ENOG4107RHR regulatoR DY471_09305 ENOG4105D9N nucleoside DY471_09310 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DY471_09330 ENOG4107RAQ aminopeptidase DY471_09395 ENOG4108T5E Copper resistance protein DY471_09400 ENOG4105KTB nuclear export factor GLE1 DY471_09405 ENOG4107RT3 EamA-like transporter family DY471_09410 ENOG4105GZI Transcriptional regulator DY471_09415 ENOG4108Z40 Transcriptional regulator DY471_09420 ENOG4107ZXU DSBA oxidoreductase DY471_09425 ENOG4108TVJ Nitroreductase DY471_09435 ENOG4106F5Q Membrane DY471_09440 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DY471_09450 ENOG4105CKI cobalamin synthesis protein DY471_09465 ENOG4108Z7G MaoC domain protein dehydratase DY471_09470 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY471_09480 ENOG4105C0Z ABC transporter DY471_09485 ENOG4108IV0 ABC, transporter DY471_09490 ENOG4105C32 Amino acid ABC transporter (Permease) DY471_09500 ENOG4105EGI Transcriptional regulator DY471_09510 ENOG4105MDS 4-oxalocrotonate tautomerase DY471_09535 ENOG4105C4M (Ubiquinol oxidase) subunit I DY471_09540 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DY471_09545 ENOG4108JJ9 ABC, transporter DY471_09550 ENOG4108JJ8 (ABC) transporter DY471_09570 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DY471_09600 ENOG4105BZ1 (ABC) transporter DY471_09605 ENOG4105EFI regulatoR DY471_09610 ENOG4105BZU Histidine kinase DY471_09620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_09655 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DY471_09660 ENOG4108ZJ4 polysaccharide deacetylase DY471_09685 ENOG4105D6E homoserine dehydrogenase DY471_09710 ENOG4108KGH TRANSCRIPTIONal DY471_09720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_09725 ENOG4105BZU Histidine kinase DY471_09730 ENOG4107VMI polysaccharide deacetylase DY471_09740 ENOG4105KT7 mgtC SapB transporter DY471_09745 ENOG4105VRR gCN5-related N-acetyltransferase DY471_09755 ENOG4105DUU IucA IucC family protein DY471_09760 ENOG4105CEY Amp-dependent synthetase and ligase DY471_09775 ENOG4108WBH protein TIM barrel DY471_09780 ENOG4105YWU small acid-soluble spore protein DY471_09790 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DY471_09795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY471_09845 ENOG4105KRN Transcriptional regulator, abrb family DY471_09855 ENOG4105YVS arsR family transcriptional regulator DY471_09860 ENOG4105CPC Aldo Keto reductase DY471_09865 ENOG4107XZQ multidrug resistance protein DY471_09890 ENOG4105C8Q Methyl-accepting chemotaxis DY471_09905 ENOG4108K88 Membrane DY471_09910 ENOG4108WPJ Ferritin-like domain DY471_09925 ENOG4105DEN Luciferase family DY471_09945 ENOG4107QM2 Aldo Keto reductase DY471_09955 ENOG4105CKI cobalamin synthesis protein DY471_09965 ENOG4105DSE periplasmic solute binding protein DY471_09970 ENOG4105K4T epimerase DY471_09980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DY471_10005 ENOG4105CVJ phosphoglycerate mutase DY471_10025 ENOG4107T5V SNARE associated Golgi DY471_10040 ENOG4108PJD permease DY471_10050 ENOG4108S4H thioesterase Superfamily protein DY471_10060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY471_10080 ENOG4105SXS Protein of unknown function (DUF456) DY471_10085 ENOG4105C37 (CBS) domain DY471_10105 ENOG4108Z7R Chaperone CsaA DY471_10125 ENOG4108ZRV stage ii sporulation protein p DY471_10140 ENOG4108VXD carboxy-peptidase DY471_10150 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY471_10170 ENOG4105EFA 4-hydroxyphenylacetate DY471_10180 ENOG4105U1N riboflavin DY471_10195 ENOG4105KME endoribonuclease L-psp DY471_10225 ENOG41069HH 4-oxalocrotonate tautomerase DY471_10235 ENOG4108X4Q Hydrolase DY471_10245 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DY471_10250 ENOG4107UWY Methyltransferase DY471_10265 ENOG41087PP glycosyltransferase MGT family DY471_10270 ENOG4108JYZ YitT family DY471_10275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY471_10305 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DY471_10390 ENOG4105KBJ sporulation protein ytfj DY471_10415 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DY471_10435 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DY471_10440 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DY471_10445 ENOG4105VTR Integrase DY471_10605 ENOG4105CAR Terminase, large subunit DY471_10615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY471_10695 ENOG4105XSJ toxin secretion phage lysis holin DY471_10700 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DY471_10745 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DY471_10750 ENOG4105EMN RNA polymerase sigma factor DY471_10775 ENOG4105CNW domain protein DY471_10800 ENOG4108V06 Glutathione peroxidase DY471_10815 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY471_10835 ENOG4108IUE nitrate reductase beta subunit DY471_10840 ENOG4105R3A Nitrate reductase DY471_10850 ENOG4107V6Q Cyclic nucleotide-binding domain DY471_10855 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DY471_10865 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY471_10870 ENOG4108ZAF Molybdopterin DY471_10895 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DY471_10900 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DY471_10905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DY471_10910 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DY471_10915 ENOG4108IFG nitrite reductase, (NAD(P)H) DY471_10920 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DY471_10955 ENOG4105MCT stage V sporulation protein S DY471_11015 ENOG4105C5H ABC transporter DY471_11030 ENOG4108UUM single-stranded DNA-binding protein DY471_11050 ENOG4107YX5 Pfam:DUF548 DY471_11110 ENOG4105C5S asparaginyl-tRNA synthetase DY471_11130 ENOG4105EC2 ftsk spoIIIe DY471_11225 ENOG4105C8J )-transporter DY471_11245 ENOG4107XGZ Hydrolase DY471_11250 ENOG4105CY2 Citrate transporter DY471_11255 ENOG4105C0A alcohol dehydrogenase DY471_11270 ENOG4105KD7 acetyltransferase DY471_11275 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DY471_11300 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DY471_11320 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DY471_11335 ENOG4107RVG penicillin-binding protein DY471_11345 ENOG4105E9Q Acyl-transferase DY471_11350 ENOG4108UT2 hemolysin iii DY471_11360 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DY471_11370 ENOG4108RCR degv family DY471_11375 ENOG4105E8R UPF0173 metal-dependent hydrolase DY471_11380 ENOG4108KF3 Electron transport protein SCO1 SenC DY471_11385 ENOG4107Y70 Heat shock protein DY471_11390 ENOG4105CAQ asparagine synthetase DY471_11410 ENOG4108MES Periplasmic binding protein DY471_11415 ENOG4105F0I Aminotransferase DY471_11445 ENOG4107Y70 Heat shock protein DY471_11450 ENOG4105D8X mechanosensitive ion channel DY471_11455 ENOG4105BZU Histidine kinase DY471_11460 ENOG4105WH1 Two component transcriptional regulator luxr family DY471_11465 ENOG4106KNT transcriptional regulator DY471_11495 ENOG4105CMG Carbohydrate kinase DY471_11500 ENOG4105CMG Carbohydrate kinase DY471_11530 ENOG4108IJ8 ABC transporter DY471_11535 ENOG4105E90 ABC transporter DY471_11570 ENOG4105C37 (CBS) domain DY471_11595 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY471_11610 ENOG4107S4Y M20 DapE family protein YgeY DY471_11615 ENOG4108TSC N-acetyltransferase DY471_11620 ENOG4108JUB Transcriptional regulator DY471_11630 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DY471_11670 ENOG4108N23 SpoOM-related protein DY471_11675 ENOG410841Q phosphoesterase PA-phosphatase related protein DY471_11685 ENOG4105SZ6 Thioredoxin DY471_11755 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY471_11800 ENOG4105BZ4 penicillin-binding protein DY471_11810 ENOG4105CZM Major Facilitator DY471_11815 ENOG4105W8X HesB YadR YfhF-family protein DY471_11825 ENOG4105DXD 2-methylcitrate dehydratase DY471_11830 ENOG4105CR4 methylisocitrate lyase DY471_11835 ENOG4105C1G acyl-Coa dehydrogenase DY471_11840 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY471_11850 ENOG4105N14 lysine exporter protein LysE YggA DY471_11855 ENOG4105E39 Enoyl-CoA hydratase DY471_11870 ENOG4107RFY SbcCD D subunit DY471_11895 ENOG4105FCD Major Facilitator DY471_11905 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DY471_11910 ENOG4105E4F Isochorismate synthase DY471_11915 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DY471_11920 ENOG4105WQI isochorismatase DY471_11925 ENOG4105CEY Amp-dependent synthetase and ligase DY471_11930 ENOG4105WQT MbtH domain protein DY471_11935 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_11950 ENOG4105K70 DNA-binding protein DY471_11970 ENOG4105BZG amino acid carrier protein DY471_11990 ENOG4105FE9 pseudouridine synthase DY471_11995 ENOG4105C22 threonyL-tRNA synthetase DY471_12000 ENOG4105C19 ABC transporter DY471_12010 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DY471_12060 ENOG41081I9 integral membrane protein DY471_12075 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY471_12085 ENOG4105EYF MMPL domain protein DY471_12110 ENOG4105WCN acetyltransferase DY471_12135 ENOG4105C1Q protoporphyrinogen oxidase DY471_12150 ENOG41068WN DY471_12160 ENOG4105VEQ Cold shock protein DY471_12180 ENOG410667J hydrolase DY471_12200 ENOG4107V2S Transcriptional regulator DY471_12205 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY471_12220 ENOG4105DND Transcriptional regulator DY471_12225 ENOG4108RPX mosc domain containing protein DY471_12240 ENOG4105BZ1 (ABC) transporter DY471_12245 ENOG4105BZ1 (ABC) transporter DY471_12265 ENOG4108JCI Transcriptional regulator DY471_12295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DY471_12310 ENOG4108KPJ rna polymerase sigma factor DY471_12330 ENOG4105F32 YngK protein DY471_12355 ENOG4105RD7 BadF BadG BcrA BcrD DY471_12365 ENOG4107STF Involved in phosphonate degradation (By similarity) DY471_12385 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY471_12400 ENOG4105C1J atp-dependent rna helicase DY471_12415 ENOG4108RZE Tetr family transcriptional regulator DY471_12430 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DY471_12435 ENOG41088CC tellurite resistance protein tehB DY471_12445 ENOG4107RA9 decarboxylase DY471_12450 ENOG41090HR transcriptional regulator DY471_12480 ENOG4105CIN aminoacyl-histidine dipeptidase DY471_12490 ENOG4105EQK -acetyltransferase DY471_12500 ENOG4107RVG penicillin-binding protein DY471_12515 ENOG4107RF6 penicillin-binding protein DY471_12520 ENOG4107RF6 penicillin-binding protein DY471_12535 ENOG4105ETE Transcriptional regulator (LacI family DY471_12540 ENOG4105IE8 Alpha-ketoglutarate permease DY471_12545 ENOG4105CK5 oxidoreductase DY471_12570 ENOG4105D2N Aldolase DY471_12575 ENOG4105DH8 myo-inositol catabolism DY471_12605 ENOG4105EXC Acyl-transferase DY471_12660 ENOG4105BZU Histidine kinase DY471_12670 ENOG4105CZV ABC transporter DY471_12715 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DY471_12770 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DY471_12800 ENOG4105CJ1 ABC, transporter DY471_12810 ENOG4107Z3H Transcriptional regulator, TetR family DY471_12825 ENOG4105C1G acyl-Coa dehydrogenase DY471_12830 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DY471_12835 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DY471_12840 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DY471_12845 ENOG4105E39 Enoyl-CoA hydratase DY471_12850 ENOG4107QX3 carboxylase DY471_12855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY471_12865 ENOG4105WCN acetyltransferase DY471_12870 ENOG4105DBI uridine monophosphokinase DY471_12900 ENOG4105T9C HD domain DY471_12910 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DY471_12935 ENOG41075H3 AraC family transcriptional regulator DY471_12975 ENOG4105FQP Beta-lactamase DY471_13015 ENOG4105CUV Homoserine Kinase DY471_13050 ENOG4105CPQ Dehydrogenase DY471_13055 ENOG410900G Protein of unknown function (DUF421) DY471_13070 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DY471_13080 ENOG4105DK7 lysyl-tRNA synthetase DY471_13145 ENOG4105D6E homoserine dehydrogenase DY471_13160 ENOG4105ETU transcriptional activator (TenA DY471_13245 ENOG410667J hydrolase DY471_13250 ENOG4105BZU Histidine kinase DY471_13255 ENOG4107RF6 penicillin-binding protein DY471_13290 ENOG4108HGU Histidine kinase DY471_13300 ENOG4105RHY Pfam:UPF0157 DY471_13305 ENOG4105CB2 alcohol dehydrogenase DY471_13310 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DY471_13315 ENOG4105CJN penicillin-binding protein DY471_13320 ENOG4108IG5 Transcriptional regulator DY471_13325 ENOG4105CHR reductase DY471_13375 ENOG4108V4B ThiJ pfpI DY471_13405 ENOG4107TXC Transcriptional regulator DY471_13415 ENOG4107Y80 Major Facilitator superfamily DY471_13430 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DY471_13455 ENOG4107Y9U Membrane DY471_13480 ENOG4105FCD Major Facilitator DY471_13495 ENOG4105E09 nadh pyrophosphatase DY471_13500 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DY471_13505 ENOG4108Z4K mutator MutT protein DY471_13540 ENOG4108XI2 Domain of unknown function (DUF1963) DY471_13560 ENOG4108NRW Phospholipase, patatin family DY471_13565 ENOG4105KWG Pfam:DUF1696 DY471_13600 ENOG4105PKS Excinuclease abc c subunit domain protein DY471_13635 ENOG4107VFR oxidoreductase DY471_13655 ENOG4105PAD Hydrolase DY471_13680 ENOG4108IUM Glycogen debranching enzyme DY471_13705 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DY471_13710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DY471_13720 ENOG4105FDR Membrane DY471_13780 ENOG4105MSI germination protein ypeb DY471_13815 ENOG4107Z3H Transcriptional regulator, TetR family DY471_13850 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DY471_13865 ENOG4105E98 transcriptional regulator DeoR family DY471_13890 ENOG4107QKR Dehydrogenase DY471_13900 ENOG4107RUY (E1 component), alpha subunit DY471_13910 ENOG4105E1F short-chain dehydrogenase reductase DY471_13915 ENOG4105RHY Pfam:UPF0157 DY471_13950 ENOG4107SQ8 Glycine betaine DY471_13955 ENOG4108IJ7 Glycine betaine DY471_13980 ENOG4105E66 phosphoriboisomerase A DY471_13985 ENOG41082BV acetyltransferase DY471_13990 ENOG4108M1A Chitin-binding protein DY471_13995 ENOG41087PP glycosyltransferase MGT family DY471_14020 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY471_14035 ENOG4108Z7F N-acetyltransferase DY471_14055 ENOG4105EEM helicase DY471_14075 ENOG4105C9U ATP-dependent DNA helicase RecQ DY471_14120 ENOG4108M1A Chitin-binding protein DY471_14140 ENOG4105BZG amino acid carrier protein DY471_14145 ENOG4105C26 Dehydrogenase DY471_14150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY471_14155 ENOG4105CTU Proline racemase DY471_14160 ENOG4105CTU Proline racemase DY471_14165 ENOG41080HI glycine oxidase DY471_14175 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DY471_14205 ENOG4107T5V SNARE associated Golgi DY471_14220 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DY471_14225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DY471_14240 ENOG4105DTQ mandelate racemase muconate lactonizing DY471_14300 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DY471_14305 ENOG4105BZU Histidine kinase DY471_14310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_14340 ENOG4105DPN Oligoendopeptidase f DY471_14345 ENOG4105DVH amino acid DY471_14365 ENOG4105EPR degv family DY471_14425 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DY471_14430 ENOG4106K7D Major facilitator family transporter DY471_14450 ENOG4107BMA Transglycosylase associated protein DY471_14465 ENOG41089UC methyltransferase, type 11 DY471_14500 ENOG4105CHM Aminotransferase DY471_14515 ENOG4108ZMI UPF0477 protein DY471_14530 ENOG4105DVE abc transporter atp-binding protein DY471_14580 ENOG4105C02 permease DY471_14590 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DY471_14595 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DY471_14600 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DY471_14645 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DY471_14690 ENOG4107VC0 DNA alkylation repair enzyme DY471_14695 ENOG4107VMI polysaccharide deacetylase DY471_14700 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC DY471_14710 ENOG4106ETB IIa component DY471_14715 ENOG4108ZCF integral membrane protein DY471_14720 ENOG4105E0M Sulfatase DY471_14730 ENOG4105C5H ABC transporter DY471_14740 ENOG4105EYF MMPL domain protein DY471_14745 ENOG41082JN Transcriptional regulator DY471_14775 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DY471_14820 ENOG4105CY2 Citrate transporter DY471_14825 ENOG4105E39 Enoyl-CoA hydratase DY471_14830 ENOG4105J5T Amp-dependent synthetase and ligase DY471_14835 ENOG4108JUB Transcriptional regulator DY471_14850 ENOG4105D4B ABC, transporter DY471_14860 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DY471_14870 ENOG4105DKT Transcriptional regulator DY471_14875 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DY471_14885 ENOG41061GT Aldolase DY471_14910 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DY471_14940 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DY471_14945 ENOG4105II7 pyrroline-5-carboxylate reductase DY471_14965 ENOG4107258 Transcriptional regulator DY471_14980 ENOG4105E0Y RtcB Protein DY471_14985 ENOG4105ECK Fatty Acid Desaturase DY471_14990 ENOG4105G6Z alkaline phosphatase DY471_15000 ENOG4105VMP Transcriptional regulator DY471_15015 ENOG41090T1 Membrane DY471_15025 ENOG4108WCX response regulator DY471_15035 ENOG41068WN DY471_15065 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY471_15110 ENOG4105CKK Glycosyl transferase, family 2 DY471_15120 ENOG4105C8Y Acetylornithine aminotransferase DY471_15180 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY471_15190 ENOG4108TVJ Nitroreductase DY471_15195 ENOG4105FS7 Transcriptional regulator DY471_15215 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DY471_15230 ENOG4105C19 ABC transporter DY471_15255 ENOG4108DMH HTH_ARAC DY471_15260 ENOG4108XET gCN5-related N-acetyltransferase DY471_15330 ENOG410635A Membrane DY471_15340 ENOG4108IQI permease DY471_15350 ENOG4105F1N DNA alkylation repair DY471_15385 ENOG4107RF6 penicillin-binding protein DY471_15425 ENOG4105P4J Allophanate hydrolase, subunit 1 DY471_15430 ENOG4107258 Transcriptional regulator DY471_15440 ENOG4106N3A copper homeostasis protein cutc DY471_15445 ENOG4108ZRV stage ii sporulation protein p DY471_15450 ENOG4108ZHR arsR family transcriptional regulator DY471_15460 ENOG4105FDT acyl-CoA dehydrogenase DY471_15475 ENOG4105DWD nucleoside recognition domain protein DY471_15500 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DY471_15555 ENOG4105E2A Dehydrogenase DY471_15565 ENOG4108IJ0 Aspartate ammonia-lyase DY471_15570 ENOG4105HDK L-asparaginase DY471_15575 ENOG4108IMY Transcriptional regulator DY471_15580 ENOG4105DQ6 Transposase DY471_15585 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DY471_15590 ENOG4105CUB amino acid DY471_15595 ENOG4105II7 pyrroline-5-carboxylate reductase DY471_15600 ENOG4108NHD germination protein DY471_15605 ENOG4108Q8B Spore germination protein DY471_15630 ENOG4105CSV Glutaminase DY471_15665 ENOG4105CGH 5'-nucleotidase DY471_15670 ENOG4105CH6 catalase DY471_15680 ENOG4105CHJ isochorismatase hydrolase DY471_15770 ENOG4108606 TspO/MBR family DY471_15775 ENOG4105CVP deoxyribo-dipyrimidine photolyase DY471_15790 ENOG4108TWJ NADH dehydrogenase subunit 5 DY471_15795 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DY471_15815 ENOG4105E1K spore germination protein DY471_15830 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DY471_15835 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DY471_15845 ENOG4105C19 ABC transporter DY471_15860 ENOG4108NEV two component transcriptional regulator, LytTR family DY471_15900 ENOG4105D6J arsenicaL-resistance protein DY471_15905 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_15910 ENOG41085FC arsR family transcriptional regulator DY471_15925 ENOG4105F7F Chaperone DY471_15940 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DY471_16015 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DY471_16020 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_16045 ENOG4105IIP Membrane DY471_16090 ENOG4105K6H D-cysteine desulfhydrase DY471_16115 ENOG4108NNI Beta-lactamase domain-containing protein DY471_16120 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase DY471_16130 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY471_16160 ENOG4105W1Y Transcriptional regulator DY471_16165 ENOG4105JQZ Methyltransferase DY471_16185 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DY471_16200 ENOG4105BZU Histidine kinase DY471_16215 ENOG4108U05 Transcriptional regulator DY471_16220 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DY471_16230 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DY471_16245 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DY471_16260 ENOG4108JQ1 Dehydrogenase DY471_16280 ENOG41082W1 Cupin 2, conserved barrel domain protein DY471_16290 ENOG410874W AraC family transcriptional regulator DY471_16310 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY471_16350 ENOG4108ISG Major Facilitator DY471_16365 ENOG4107MII Sugar-specific transcriptional regulator TrmB DY471_16370 ENOG4105CZM Major Facilitator DY471_16380 ENOG4105RXJ DY471_16385 ENOG4105KPY Small multidrug resistance protein DY471_16390 ENOG4105KBX Transcriptional regulator, TetR family DY471_16400 ENOG4105CRW Short chain fatty acid transporter DY471_16410 ENOG4105DYS nad(p)h dehydrogenase (quinone) DY471_16440 ENOG4108JJB ABC transporter DY471_16445 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DY471_16485 ENOG4107TXC Transcriptional regulator DY471_16500 ENOG41067QW Transcriptional regulator DY471_16510 ENOG4108Z66 YbaK ebsC protein DY471_16530 ENOG4105KVH Transcriptional regulator DY471_16535 ENOG4108RCM Nitroreductase DY471_16555 ENOG4108PSK reductase DY471_16565 ENOG4105CJ1 ABC, transporter DY471_16635 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_16640 ENOG4105DKQ ROK family DY471_16645 ENOG4106UW1 Major Facilitator superfamily DY471_16650 ENOG4108UW5 maltose o-acetyltransferase DY471_16660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DY471_16665 ENOG4105C31 Tryptophanyl-tRNA synthetase DY471_16690 ENOG4105DMQ Methyltransferase DY471_16700 ENOG4105EV4 Multidrug resistance protein mdtH DY471_16730 ENOG4105C37 (CBS) domain DY471_16745 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DY471_16750 ENOG4105FAW cDP-glucose 4,6-dehydratase DY471_16780 ENOG4105DDN Pentapeptide repeat-containing protein DY471_16785 ENOG4105XDF Protein of unknown function (DUF1272) DY471_16790 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DY471_16795 ENOG4105CMG Carbohydrate kinase DY471_16800 ENOG4105C6Z Gluconate DY471_16805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DY471_16820 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DY471_16825 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DY471_16830 ENOG4105CIS alcohol dehydrogenase DY471_16835 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone DY471_16850 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DY471_16855 ENOG4105D4Y metalloprotease DY471_16865 ENOG4105C8Q Methyl-accepting chemotaxis DY471_16870 ENOG4108UX3 '-nucleotidase DY471_16875 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DY471_16880 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DY471_16885 ENOG4105KVH Transcriptional regulator DY471_16905 ENOG4105CV8 reductase DY471_16910 ENOG4105F27 Major Facilitator DY471_16925 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DY471_16930 ENOG4105C44 Serine transporter DY471_16960 ENOG4105KVH Transcriptional regulator DY471_16965 ENOG4108TZY GntR Family Transcriptional Regulator DY471_16970 ENOG4105D9R oxidoreductase DY471_16975 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DY471_16980 ENOG4105KVH Transcriptional regulator DY471_16985 ENOG4105KVH Transcriptional regulator DY471_17025 ENOG4105JAB phenazine biosynthesis protein, phzf family DY471_17035 ENOG4105CHR reductase DY471_17050 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DY471_17055 ENOG4105KVH Transcriptional regulator DY471_17065 ENOG4108ZJ4 polysaccharide deacetylase DY471_17120 ENOG4105KAF membrAne DY471_17145 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DY471_17160 ENOG4107YXZ hydrolase, family 25 DY471_17195 ENOG4105H3G oxidoreductase DY471_17240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY471_17280 ENOG4105CIS alcohol dehydrogenase DY471_17315 ENOG4108TN2 lmbE family DY471_17325 ENOG4107R3E Citrate transporter DY471_17340 ENOG4108MES Periplasmic binding protein DY471_17345 ENOG4105EHG Permease protein DY471_17350 ENOG4105DQ5 transport system permease protein DY471_17355 ENOG4105NX3 Membrane DY471_17360 ENOG4107ZY0 Phenazine biosynthesis-like protein DY471_17385 ENOG4107CUJ Protein of unknown function (DUF2690) DY471_17395 ENOG4107V2S Transcriptional regulator DY471_17405 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DY471_17420 ENOG4105C98 muts2 protein DY471_17430 ENOG4105E5K Alpha-amylase DY471_17435 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DY471_17440 ENOG4105DPN Oligoendopeptidase f DY471_17445 ENOG4108A04 Beta-lactamase DY471_17480 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DY471_17505 ENOG41082BM Transcriptional regulator, arsr family DY471_17510 ENOG4105CIS alcohol dehydrogenase DY471_17520 ENOG4107JM4 Tetratricopeptide repeat DY471_17545 ENOG4105C09 Bile acid DY471_17550 ENOG4105CQB FAD linked oxidase domain protein DY471_17575 ENOG4108UT6 Transferase hexapeptide repeat containing protein DY471_17585 ENOG4105K64 Glycosyl transferase, family 2 DY471_17590 ENOG4105E39 Enoyl-CoA hydratase DY471_17600 ENOG4105KT7 mgtC SapB transporter DY471_17615 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_17620 ENOG41073R8 VanW family DY471_17630 ENOG4108R1P DY471_17650 ENOG4105VEQ Cold shock protein DY471_17690 ENOG410904N short-chain dehydrogenase reductase DY471_17700 ENOG4106IQC argininosuccinate lyase DY471_17715 ENOG4108IA2 Sodium pantothenate symporter DY471_17725 ENOG4105C26 Dehydrogenase DY471_17730 ENOG4105CHR reductase DY471_17740 ENOG4105EWU Squalene--hopene cyclase DY471_17750 ENOG4105FR1 rard protein DY471_17755 ENOG410696E Membrane DY471_17770 ENOG4105D1F ATP-binding protein DY471_17780 ENOG4108ZAF Molybdopterin DY471_17785 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY471_17790 ENOG4105D06 uba thif-type nad fad binding protein DY471_17795 ENOG4105TMB Formate nitrite transporter DY471_17805 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DY471_17810 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DY471_17820 ENOG4108JB9 formate dehydrogenase DY471_17825 ENOG4105E1K spore germination protein DY471_17840 ENOG4105CUB amino acid DY471_17900 ENOG4107QJT sodium dicarboxylate symporter DY471_17905 ENOG4108KGH TRANSCRIPTIONal DY471_17915 ENOG4105EMN RNA polymerase sigma factor DY471_17930 ENOG4105CIG ABC transporter DY471_17940 ENOG4105D9R oxidoreductase DY471_17950 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY471_17955 ENOG4105K4P CoA-binding domain protein DY471_17960 ENOG4105C0H protease DY471_17965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_17975 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DY471_17985 ENOG4105W8X HesB YadR YfhF-family protein DY471_18015 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DY471_18020 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DY471_18035 ENOG4108I0Z Aconitate hydratase DY471_18065 ENOG4105E5W Transporter DY471_18075 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY471_18095 ENOG4107F3J Amp-dependent synthetase and ligase DY471_18100 ENOG4107ZYJ bioY protein DY471_18105 ENOG4105CEY Amp-dependent synthetase and ligase DY471_18120 ENOG4108IMY Transcriptional regulator DY471_18175 ENOG4107AYK membrAne DY471_18190 ENOG4105BZU Histidine kinase DY471_18195 ENOG4105FBA Phospholipase Carboxylesterase DY471_18200 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DY471_18205 ENOG4105CK7 Sodium proline symporter DY471_18210 ENOG4105CBC glutamate synthase DY471_18215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DY471_18220 ENOG4108VJ1 Transcriptional regulator (CarD family DY471_18225 ENOG4108903 Formimidoylglutamase DY471_18295 ENOG4107QIV Cytochrome c biogenesis protein DY471_18310 ENOG4105CH2 amidohydrolase DY471_18320 ENOG4105CJ1 ABC, transporter DY471_18330 ENOG4107RSM transcriptional regulator DY471_18340 ENOG41067MG lrgb family DY471_18380 ENOG4105BZ1 (ABC) transporter DY471_18385 ENOG4105BZ1 (ABC) transporter DY471_18430 ENOG4105CGH 5'-nucleotidase DY471_18440 ENOG4108SVB resolvase DY471_18460 ENOG4105K7K Transcriptional regulator DY471_18600 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY471_18610 ENOG4105CAR Terminase, large subunit DY471_18765 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY471_18770 ENOG4105C5F glutamine synthetase DY471_18775 ENOG4105KV4 Transcriptional regulator DY471_18780 ENOG4105CXI aluminum resistance protein DY471_18785 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DY471_18790 ENOG4105EN6 Membrane DY471_18795 ENOG4106F1P AAA ATPase, central domain protein DY471_18825 ENOG41069ER domain protein DY471_18830 ENOG4105DM4 PTS System DY471_18835 ENOG4105DE4 1-phosphofructokinase DY471_18840 ENOG4105E98 transcriptional regulator DeoR family DY471_18845 ENOG4107QW4 alcohol dehydrogenase DY471_18850 ENOG4108SJC Membrane DY471_18860 ENOG4105C85 amino acid DY471_18880 ENOG4105TMB Formate nitrite transporter DY471_18885 ENOG4105K70 DNA-binding protein DY471_18895 ENOG4105C59 p-type ATPase DY471_18900 ENOG410681U heavy metal transport detoxification protein DY471_18905 ENOG4105VPX protein, conserved in bacteria DY471_18915 ENOG4105NIV Esterase DY471_18920 ENOG4105E0A ABC, transporter DY471_18940 ENOG4105CGK Exodeoxyribonuclease III DY471_18950 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DY471_18955 ENOG4105D03 DNA-3-methyladenine glycosylase II DY471_18985 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_18990 ENOG4105BZU Histidine kinase DY471_19020 ENOG4107TTQ Alpha beta hydrolase fold DY471_19025 ENOG4107YEI lmbE family DY471_19050 ENOG4105F0V Cell wall hydrolase DY471_19065 ENOG4105E0M Sulfatase DY471_19070 ENOG410890F Dynamin family DY471_19080 ENOG4107QHE Choloylglycine hydrolase DY471_19105 ENOG4105DA5 (ABC) transporter DY471_19135 ENOG4105DQU oxidoreductase, subunit beta DY471_19140 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DY471_19145 ENOG4108IGT Dipeptidase DY471_19150 ENOG4105MCT stage V sporulation protein S DY471_19180 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DY471_19195 ENOG4105XZV Protein of unknown function (DUF3243) DY471_19200 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DY471_19220 ENOG4105UIB (ABC) transporter DY471_19225 ENOG4108JQ9 ABC transporter DY471_19230 ENOG4105DIH basic membrane DY471_19235 ENOG4105FDP GntR family transcriptional regulator DY471_19245 ENOG4107QZI cell division protein FtsK DY471_19255 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DY471_19270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY471_19280 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY471_19285 ENOG4108S0H Dipicolinic acid synthetase, b subunit DY471_19310 ENOG4105XSJ toxin secretion phage lysis holin DY471_19445 ENOG4105CDU Replicative dna helicase DY471_19525 ENOG4105E35 Dipicolinate synthase subunit A DY471_19535 ENOG4105C1V Peptidase, M16 DY471_19555 ENOG4105DTN riboflavin biosynthesis protein ribF DY471_19570 ENOG4105W7A Protein of unknown function (DUF503) DY471_19580 ENOG4105VHM ribosomal protein DY471_19585 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DY471_19590 ENOG4105CHV Transcription elongation factor NusA DY471_19600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DY471_19610 ENOG4105DZP Membrane-associated zinc metalloprotease DY471_19615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DY471_19620 ENOG4105KNE Phosphatidate cytidylyltransferase DY471_19665 ENOG4108HE4 integrase family DY471_19675 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DY471_19680 ENOG4105C79 DNA protecting protein DprA DY471_19685 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DY471_19700 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DY471_19725 ENOG4105VB6 UPF0109 protein DY471_19745 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DY471_19750 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DY471_19765 ENOG4105CHR reductase DY471_19770 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DY471_19785 ENOG4105CB5 ATP-dependent DNA helicase recG DY471_19790 ENOG4105DP4 dak2 domain fusion protein ylov DY471_19795 ENOG4108ZAA Alkaline-shock protein DY471_19810 ENOG4105FJ0 thiamine DY471_19815 ENOG4105DJV ribulose-phosphate 3-epimerase DY471_19825 ENOG4105D9P serine threonine protein kinase DY471_19830 ENOG4108ZF3 Phosphatase DY471_19840 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DY471_19850 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY471_19855 ENOG4105C25 Primosomal protein n' DY471_19860 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DY471_19880 ENOG4105DSJ YicC domain protein DY471_19890 ENOG4105F23 Fibronectin-binding protein DY471_19895 ENOG4105DC7 peptidase M24 DY471_19955 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DY471_19980 ENOG4105C34 Pseudouridine synthase DY471_20005 ENOG4105DBK s4 domain protein DY471_20010 ENOG41067XK integral membrane protein DY471_20020 ENOG4105DFA alanine racemase domain protein DY471_20025 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DY471_20030 ENOG4105WR5 sporulation protein, YlmC YmxH family DY471_20040 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_20050 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DY471_20055 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DY471_20060 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DY471_20070 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DY471_20075 ENOG4105CNI cell division protein FtsW DY471_20090 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DY471_20095 ENOG4105CJN penicillin-binding protein DY471_20100 ENOG4105CJN penicillin-binding protein DY471_20105 ENOG41068DC Essential cell division protein (By similarity) DY471_20140 ENOG4105KNH Nucleic acid-binding protein DY471_20150 ENOG41063PX domain protein DY471_20155 ENOG4105D78 K07001 NTE family protein DY471_20160 ENOG4105H20 Sporulation integral membrane protein YlbJ DY471_20170 ENOG4106H78 methyltransferase DY471_20190 ENOG4107TB6 phosphoglycerate mutase DY471_20205 ENOG4106UY4 Inherit from COG: Scp-like extracellular DY471_20255 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DY471_20265 ENOG4105CNI cell division protein FtsW DY471_20280 ENOG4108IAB Phoh family DY471_20300 ENOG4105QA2 DY471_20305 ENOG4105CI3 gtp-binding protein typa DY471_20315 ENOG4105ECY inositol monophosphatase DY471_20335 ENOG4105CXN decarboxylase DY471_20385 ENOG4105CPP Dehydrogenase, E1 component DY471_20400 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY471_20405 ENOG4108X4Q Hydrolase DY471_20420 ENOG4105CN5 Metallo-Beta-Lactamase DY471_20425 ENOG4107ZYR domain protein DY471_20460 ENOG4108XRC Protein of unknown function (DUF458) DY471_20465 ENOG4107IN1 Protein of unknown function (DUF1797) DY471_20480 ENOG4105EPM Diguanylate phosphodiesterase DY471_20485 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DY471_20505 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DY471_20515 ENOG4105UIN DY471_20545 ENOG4105D7V transposase DY471_20580 ENOG4108HGU Histidine kinase DY471_20590 ENOG4105CHM Aminotransferase DY471_20595 ENOG4105FKQ transcriptional regulator DY471_20600 ENOG4105EG2 ABC transporter, permease DY471_20610 ENOG4107FKK extracellular solute-binding protein family 1 DY471_20620 ENOG4105CG3 alpha amylase, catalytic region DY471_20665 ENOG4105CHU acetyl-coa acetyltransferase DY471_20700 ENOG4105K7K Transcriptional regulator DY471_20705 ENOG4105DTD Dehydrogenase DY471_20725 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DY471_20765 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY471_20770 ENOG4105BZU Histidine kinase DY471_20790 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DY471_20805 ENOG4105CID antiterminator DY471_20815 ENOG4105FDP GntR family transcriptional regulator DY471_20825 ENOG4105CE4 GlcNAc 6-P deacetylase DY471_20870 ENOG4107ZE5 PPIases accelerate the folding of proteins DY471_20875 ENOG4105PTM secreted protein DY471_20880 ENOG4105J7I hydrolase DY471_20890 ENOG4105G6R Stage v sporulation protein ae DY471_20900 ENOG4105CZ3 stage V sporulation protein ad DY471_20905 ENOG41090VF Stage v sporulation protein ac DY471_20925 ENOG4105C8J )-transporter DY471_20930 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_20940 ENOG41082AN stage II sporulation protein DY471_20945 ENOG4105DZ1 carboxypeptidase DY471_20955 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DY471_20960 ENOG4105DVE abc transporter atp-binding protein DY471_20990 ENOG4105D7N magnesium and cobalt transport protein CorA DY471_21015 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY471_21025 ENOG4105I3K Ferric uptake regulator, Fur family DY471_21030 ENOG4105MZ9 stage II sporulation protein m DY471_21050 ENOG4105CPC Aldo Keto reductase DY471_21060 ENOG4105RHY Pfam:UPF0157 DY471_21080 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DY471_21090 ENOG4105ETE Transcriptional regulator (LacI family DY471_21095 ENOG4108YM7 Gcn5-related n-acetyltransferase DY471_21115 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DY471_21120 ENOG4108R6K riboflavin synthase, subunit alpha DY471_21140 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DY471_21145 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY471_21150 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY471_21165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY471_21175 ENOG4105DFD Na H antiporter DY471_21180 ENOG4105CGH 5'-nucleotidase DY471_21235 ENOG4108IXY short-chain dehydrogenase reductase DY471_21240 ENOG41069FQ Metallo-beta-lactamase superfamily DY471_21245 ENOG4105II7 pyrroline-5-carboxylate reductase DY471_21250 ENOG4105EJQ L-serine dehydratase DY471_21290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DY471_21295 ENOG4105D9U N-acetyltransferase DY471_21305 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DY471_21310 ENOG4108QEG Membrane DY471_21315 ENOG4105CDA abc transporter atp-binding protein DY471_21320 ENOG4105E5Q amino acid AbC transporter DY471_21325 ENOG4108HW3 (ABC) transporter DY471_21340 ENOG4105G7B Protein of unknown function (DUF2992) DY471_21350 ENOG4108QY0 Membrane DY471_21360 ENOG4105C7S Dehydrogenase DY471_21365 ENOG4105CPP Dehydrogenase, E1 component DY471_21385 ENOG4107RDP Dehydrogenase DY471_21400 ENOG4108JUB Transcriptional regulator DY471_21405 ENOG4106CCJ Protein of unknown function (DUF2627) DY471_21410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DY471_21425 ENOG4107QQR Sporulation DY471_21435 ENOG4105S1Z Stage IV sporulation protein B DY471_21440 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DY471_21450 ENOG4105DX0 Hemolysin A DY471_21460 ENOG4105CTB Polyprenyl synthetase DY471_21485 ENOG4108ZSR alkaline shock protein DY471_21490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DY471_21515 ENOG410644B Stage III sporulation protein af DY471_21525 ENOG4105KQ4 Stage iii sporulation protein ad DY471_21530 ENOG4108CQH stage III sporulation protein AC DY471_21535 ENOG4105KR5 Stage iii sporulation protein DY471_21540 ENOG4105CD2 stage iii sporulation protein aa DY471_21565 ENOG4105DC7 peptidase M24 DY471_21580 ENOG4105CBJ Metal-dependent enzyme DY471_21590 ENOG4107YBY Hydrolase DY471_21625 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DY471_21630 ENOG4105WZW rhodanese family DY471_21650 ENOG41080TC multidrug resistance protein DY471_21685 ENOG4105CJ1 ABC, transporter DY471_21690 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DY471_21725 ENOG4105C0D helicase DY471_21845 ENOG4105C3R Methionine synthase DY471_21855 ENOG4105C28 cystathionine DY471_21860 ENOG4105C28 cystathionine DY471_21880 ENOG4105C5X domain protein DY471_21890 ENOG4105DKQ ROK family DY471_21900 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DY471_21915 ENOG4108UTW Plays a role in the regulation of phosphate uptake DY471_21920 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DY471_21925 ENOG4105E2Z phosphate ABC transporter (Permease DY471_21930 ENOG4105C8U phosphate abc transporter DY471_21935 ENOG4105PWN phosphate abc transporter DY471_21940 ENOG4107RF6 penicillin-binding protein DY471_21950 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY471_21975 ENOG4105N80 Ferric uptake regulator, Fur family DY471_21985 ENOG4105FDK ABC transporter DY471_21990 ENOG4108JYZ YitT family DY471_21995 ENOG41069ZM Protein of unknown function (DUF2624) DY471_22020 ENOG4105EGD dinuclear metal center protein, YbgI family DY471_22035 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_22040 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DY471_22065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DY471_22070 ENOG4105KG3 cytidine deaminase DY471_22075 ENOG4107YR5 Diacylglycerol kinase DY471_22085 ENOG4105CTJ Metal Dependent Phosphohydrolase DY471_22090 ENOG4105C9A Phoh family DY471_22100 ENOG41068P3 sporulation protein YqfC DY471_22105 ENOG4105KTH gatB Yqey DY471_22120 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DY471_22125 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DY471_22145 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DY471_22155 ENOG4105CSA Coproporphyrinogen iii oxidase DY471_22160 ENOG4105KVH Transcriptional regulator DY471_22185 ENOG4105TQK DNA polymerase iii, delta' subunit DY471_22195 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DY471_22200 ENOG4108UK2 deaminase DY471_22205 ENOG4105KQC Competence protein DY471_22215 ENOG4105DXX methyltransferase DY471_22225 ENOG4108WF2 Metal Dependent Phosphohydrolase DY471_22235 ENOG410812S Rna-binding protein DY471_22245 ENOG4105CQW ribosome biogenesis GTPase YqeH DY471_22250 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DY471_22265 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_22285 ENOG4108TVJ Nitroreductase DY471_22300 ENOG4105G6Z alkaline phosphatase DY471_22310 ENOG4108MUZ hydrolase DY471_22345 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DY471_22350 ENOG4105MIR Phenylalanine 4-monooxygenase DY471_22360 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_22400 ENOG4105S6R Iron-hydroxamate transporter permease subunit DY471_22405 ENOG4108HUF Transporter DY471_22415 ENOG4108EKI Dehydrogenase DY471_22420 ENOG4105C28 cystathionine DY471_22450 ENOG4107XRG penicillin-binding protein DY471_22470 ENOG4105CFP Peptidase U32 DY471_22475 ENOG4105XYU peptidase (U32 family) DY471_22480 ENOG4108VQJ O-methyltransferase DY471_22485 ENOG4105HHA aminodeoxychorismate lyase DY471_22515 ENOG4105C02 permease DY471_22530 ENOG41060CR DY471_22535 ENOG4105C7H Helicase, RecD TraA family DY471_22550 ENOG4105C3J Cysteine desulfurase DY471_22560 ENOG4105D1H recombination factor protein RarA DY471_22565 ENOG4108VCI transcription factor, rsfa family DY471_22575 ENOG4105CUZ uba thif-type nad fad binding protein DY471_22585 ENOG4105CUT histidyl-tRNA synthetase DY471_22600 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DY471_22610 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DY471_22615 ENOG41076HS cation diffusion facilitator family transporter DY471_22620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DY471_22630 ENOG4105CKP Polysaccharide Biosynthesis Protein DY471_22635 ENOG4108QG2 Membrane DY471_22645 ENOG4105VIE preprotein translocase, subunit YajC DY471_22660 ENOG41061AI Protein of unknown function (DUF2905) DY471_22675 ENOG4108HUF Transporter DY471_22685 ENOG4108IPJ Membrane DY471_22690 ENOG41082BM Transcriptional regulator, arsr family DY471_22715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DY471_22720 ENOG4108IYU L-aspartate oxidase DY471_22735 ENOG4108RPX mosc domain containing protein DY471_22740 ENOG4105CQC Prephenate dehydratase DY471_22760 ENOG4105EWM Histidine kinase DY471_22785 ENOG4105X36 (ribosomal) protein DY471_22795 ENOG4105C03 ribonuclease DY471_22810 ENOG4107QMS site-determining protein DY471_22825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DY471_22830 ENOG4105DFF Rod shape-determining protein mreb DY471_22855 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DY471_22860 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DY471_22870 ENOG41068KH stage VI sporulation protein D DY471_22880 ENOG4105D52 delta-aminolevulinic acid dehydratase DY471_22905 ENOG4105K56 Transcriptional regulator DY471_22925 ENOG4108IUQ atp-dependent protease DY471_22955 ENOG4108QCI YvbH-like oligomerisation region DY471_22970 ENOG4105M59 Phosphodiesterase, mj0936 family DY471_22975 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DY471_22985 ENOG4108XJQ germination protein DY471_22995 ENOG4108PCX Major Facilitator DY471_23005 ENOG4105KBX Transcriptional regulator, TetR family DY471_23020 ENOG4105PFC Transcriptional regulator DY471_23030 ENOG4105DZC cytosine deaminase DY471_23040 ENOG4108JCI Transcriptional regulator DY471_23050 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DY471_23055 ENOG4108Z40 Transcriptional regulator DY471_23060 ENOG4105RHA ABC transporter, permease DY471_23070 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DY471_23075 ENOG4105ER2 Ompa motb domain protein DY471_23080 ENOG4105E14 MotA TolQ exbB proton channel DY471_23085 ENOG4108VXD carboxy-peptidase DY471_23095 ENOG4105E33 succinate dehydrogenase DY471_23105 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DY471_23120 ENOG4105K63 Thioredoxin DY471_23125 ENOG4105C10 Electron transfer flavoprotein DY471_23130 ENOG4105BZJ Electron transfer flavoprotein DY471_23135 ENOG41060WC Enoyl-CoA hydratase DY471_23140 ENOG4107Z3H Transcriptional regulator, TetR family DY471_23145 ENOG4105CEY Amp-dependent synthetase and ligase DY471_23185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_23195 ENOG4105DR4 Methyltransferase DY471_23210 ENOG4105KFN sortase, SrtB family DY471_23215 ENOG4105E0A ABC, transporter DY471_23230 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DY471_23235 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DY471_23245 ENOG4105FE9 pseudouridine synthase DY471_23255 ENOG4105DCG PHP domain protein DY471_23290 ENOG4105C5S asparaginyl-tRNA synthetase DY471_23295 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DY471_23305 ENOG4108RWN rrna methyltransferase DY471_23325 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY471_23330 ENOG4105CW7 secretion protein, HlyD family DY471_23335 ENOG4108JGH Tetr family transcriptional regulator DY471_23340 ENOG4105CN9 Peptidase m42 family protein DY471_23360 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DY471_23365 ENOG4105C22 threonyL-tRNA synthetase DY471_23370 ENOG4108TDW sporulation protein YtxC DY471_23390 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DY471_23395 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DY471_23400 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DY471_23410 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DY471_23415 ENOG4105C2M dna polymerase I DY471_23420 ENOG4105BZU Histidine kinase DY471_23425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_23440 ENOG4108HMX isocitrate dehydrogenase (NADP) DY471_23445 ENOG4105BZN citrate synthase DY471_23460 ENOG4108REF Sporulation integral membrane protein ytvi DY471_23465 ENOG4105FS0 cytoplasmic membrane protein DY471_23490 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DY471_23495 ENOG4105C6K Malic enzyme DY471_23500 ENOG4105C0B DNA polymerase III (alpha subunit) DY471_23505 ENOG4105VV2 DY471_23515 ENOG4105SFS phosphoesterase RecJ domain protein DY471_23550 ENOG4105DC7 peptidase M24 DY471_23595 ENOG41082W1 Cupin 2, conserved barrel domain protein DY471_23605 ENOG4105VZ8 Transcriptional regulator DY471_23625 ENOG4107YZX Universal stress protein DY471_23685 ENOG4108JYZ YitT family DY471_23710 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DY471_23715 ENOG4105KBJ sporulation protein ytfj DY471_23730 ENOG4105EFZ amidohydrolase DY471_23740 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY471_23765 ENOG4106KR7 LysR family Transcriptional regulator DY471_23775 ENOG4105U5Y Transcriptional regulator DY471_23785 ENOG4105C28 cystathionine DY471_23805 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DY471_23815 ENOG4105EMN RNA polymerase sigma factor DY471_23835 ENOG4105F1V Acetoin utilization protein DY471_23840 ENOG4105W87 Cbs domain DY471_23845 ENOG4105DGU Histone deacetylase DY471_23850 ENOG4106HB6 Alpha beta hydrolase DY471_23855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY471_23860 ENOG4105BZU Histidine kinase DY471_23865 ENOG4107SNB ankyrin repeat protein YahD DY471_23870 ENOG4105EP9 oxidoreductase DY471_23900 ENOG4105ETE Transcriptional regulator (LacI family DY471_23930 ENOG4105C88 aminopeptidase DY471_23985 ENOG4108VDD TRNA binding domain protein DY471_24015 ENOG4105C8F Beta-lactamase domain protein DY471_24030 ENOG4108V15 phosphotransferase enzyme family DY471_24035 ENOG4108IUM Glycogen debranching enzyme DY471_24045 ENOG4107QSE Dipeptidase DY471_24050 ENOG4105YW5 deoR family transcriptional regulator DY471_24065 ENOG4105CBX hi0933 family DY471_24105 ENOG4108VJ1 Transcriptional regulator (CarD family DY471_24110 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DY471_24130 ENOG4108ZAF Molybdopterin DY471_24135 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DY471_24140 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY471_24150 ENOG4105D06 uba thif-type nad fad binding protein DY471_24155 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DY471_24175 ENOG41085GJ domain protein DY471_24185 ENOG4105DWV Homoserine O-trans-acetylase DY471_24195 ENOG4108B31 Spore germination protein DY471_24225 ENOG410605W Major Facilitator DY471_24230 ENOG4107S91 Sodium hydrogen exchanger DY471_24235 ENOG4105NCW Trka-c domain protein DY471_24250 ENOG4105C19 ABC transporter DY471_24270 ENOG4105N5T Radical SAM Protein DY471_24280 ENOG4105CIG ABC transporter DY471_24315 ENOG4105E8V Alpha Beta Hydrolase Fold protein DY471_24320 ENOG4108Z0R Transferase DY471_24325 ENOG4105YVM Phosphoesterase, PA-phosphatase related DY471_24330 ENOG4105BZF Glycosyl transferase (Group 1 DY471_24340 ENOG4108RIR Molybdenum cofactor biosynthesis protein DY471_24350 ENOG4108MK9 spermidine N(1)-acetyltransferase DY471_24390 ENOG4105EGD dinuclear metal center protein, YbgI family DY471_24395 ENOG4105BZU Histidine kinase DY471_24400 ENOG4105BZU Histidine kinase DY471_24405 ENOG4107S9D Alpha beta hydrolase DY471_24410 ENOG4107T7U Sulfatase DY471_24425 ENOG4105D2X ABC transporter substrate-binding protein DY471_24435 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DY471_24485 ENOG4108V2W Carbonate dehydratase DY471_24490 ENOG4105C4M (Ubiquinol oxidase) subunit I DY471_24495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DY471_24540 ENOG41087YS Phage shock protein A DY471_24555 ENOG4108IBT Inherit from COG: transposase DY471_24590 ENOG4105BZU Histidine kinase DY471_24595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_24620 ENOG4108UGV hypoxanthine phosphoribosyltransferase DY471_24625 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DY471_24645 ENOG4105C19 ABC transporter DY471_24670 ENOG4107ZTW SNARE associated Golgi DY471_24695 ENOG4105C19 ABC transporter DY471_24700 ENOG41086D8 Transcriptional regulator DY471_24710 ENOG4105CJ1 ABC, transporter DY471_24720 ENOG41082BM Transcriptional regulator, arsr family DY471_24760 ENOG4105C6Z Gluconate DY471_24765 ENOG4105FDP GntR family transcriptional regulator DY471_24785 ENOG41069H0 dihydroorotase EC 3.5.2.3 DY471_24810 ENOG4105DTQ mandelate racemase muconate lactonizing DY471_24820 ENOG4108IPT Naphthoate synthase DY471_24825 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DY471_24835 ENOG4105E4F Isochorismate synthase DY471_24840 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DY471_24850 ENOG4105VEQ Cold shock protein DY471_24880 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DY471_24905 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DY471_24915 ENOG4105JVQ RNA Polymerase DY471_25010 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DY471_25045 ENOG4105KT7 mgtC SapB transporter DY471_25050 ENOG4107PBV potassium channel DY471_25070 ENOG4105WG9 Conserved Protein DY471_25080 ENOG4105CHM Aminotransferase DY471_25085 ENOG4108ZB6 transcriptional regulator AsnC family DY471_25090 ENOG4105C5I Dehydrogenase DY471_25095 ENOG4108MUZ hydrolase DY471_25105 ENOG4105C87 Aminotransferase class I and II DY471_25115 ENOG4105Y38 Kinase-associated protein B DY471_25125 ENOG4107R3E Citrate transporter DY471_25140 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DY471_25145 ENOG4105KA0 thioesterase Superfamily protein DY471_25165 ENOG4107QPH glycogen) synthase DY471_25185 ENOG4105EJV Membrane DY471_25190 ENOG4105WH5 Teichoic acid glycosylation protein DY471_25200 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DY471_25225 ENOG41069ER domain protein DY471_25240 ENOG4105CEP NADH dehydrogenase DY471_25270 ENOG4105EWC Purine nucleoside phosphorylase DY471_25280 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DY471_25305 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DY471_25310 ENOG4105C4B ABC transporter, permease DY471_25345 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DY471_25370 ENOG41083MR nifu domain-containing protein DY471_25385 ENOG4108W5N phosphatidylglycerophosphatase a DY471_25400 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DY471_25405 ENOG4105DYS nad(p)h dehydrogenase (quinone) DY471_25415 ENOG4105D4U had-superfamily hydrolase, subfamily iia DY471_25430 ENOG4105CBT Fructose-1,6-bisphosphatase DY471_25445 ENOG4105MMD transcriptional regulator DY471_25450 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DY471_25455 ENOG4107TXC Transcriptional regulator DY471_25460 ENOG41090T1 Membrane DY471_25485 ENOG4105FAA peptidase M23 DY471_25495 ENOG4105KZD Domain of unknown function (DUF1805) DY471_25500 ENOG4107R8B 5'-nucleotidase DY471_25510 ENOG4105DIW FeS assembly protein SUFB DY471_25515 ENOG4108UNV SUF system FeS assembly protein, NifU family DY471_25520 ENOG4105C9B Cysteine desulfurase DY471_25525 ENOG4105JRK feS assembly protein SufD DY471_25530 ENOG4105C3K feS assembly ATPase SufC DY471_25535 ENOG4105D01 (LipO)protein DY471_25540 ENOG4105D01 (LipO)protein DY471_25545 ENOG4108UMI ABC transporter, permease DY471_25575 ENOG41080E8 Transcriptional regulator, Spx MgsR family DY471_25630 ENOG4108W8B Beta-lactamase domain protein DY471_25635 ENOG4105C1G acyl-Coa dehydrogenase DY471_25640 ENOG4105CHU acetyl-coa acetyltransferase DY471_25655 ENOG4105DZ1 carboxypeptidase DY471_25675 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY471_25690 ENOG4108SUT Major Facilitator Superfamily DY471_25695 ENOG4107R7I amino acid DY471_25710 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DY471_25720 ENOG4107AYK membrAne DY471_25760 ENOG4107ZTW SNARE associated Golgi DY471_25770 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DY471_25775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_25780 ENOG4105BZU Histidine kinase DY471_25800 ENOG4105C8Q Methyl-accepting chemotaxis DY471_25805 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY471_25810 ENOG4105VG1 fes assembly suf system protein DY471_25815 ENOG4105D4Y metalloprotease DY471_25835 ENOG4107S91 Sodium hydrogen exchanger DY471_25840 ENOG4105NCW Trka-c domain protein DY471_25850 ENOG4108RMU ferritin dps family protein DY471_25870 ENOG4108URH decarboxylase DY471_25890 ENOG4105D9N nucleoside DY471_25895 ENOG4105D9N nucleoside DY471_25910 ENOG4108RYK Nad-dependent epimerase dehydratase DY471_25925 ENOG4105CV8 reductase DY471_25930 ENOG4105F27 Major Facilitator DY471_25935 ENOG4105KVH Transcriptional regulator DY471_25950 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DY471_25965 ENOG4105C8Q Methyl-accepting chemotaxis DY471_25975 ENOG4105WMR Protein CrcB homolog DY471_25995 ENOG4108MK9 spermidine N(1)-acetyltransferase DY471_26000 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DY471_26015 ENOG4108IPW abc transporter atp-binding protein DY471_26020 ENOG4105CM4 permease protein DY471_26040 ENOG4105EWM Histidine kinase DY471_26045 ENOG4105CJZ response regulator DY471_26050 ENOG4105C19 ABC transporter DY471_26070 ENOG4105C19 ABC transporter DY471_26100 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DY471_26110 ENOG4105XZU Preprotein translocase, subunit SecG DY471_26115 ENOG41067MG lrgb family DY471_26135 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DY471_26165 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_26185 ENOG41090VF Stage v sporulation protein ac DY471_26190 ENOG4105CZ3 stage V sporulation protein ad DY471_26205 ENOG4108QY0 Membrane DY471_26210 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY471_26225 ENOG4105KRI phosphocarrier protein (HPr DY471_26235 ENOG4105CHW UPF0052 protein DY471_26245 ENOG4108Z4K mutator MutT protein DY471_26255 ENOG4105C3M thioredoxin reductase DY471_26265 ENOG4108S4C acetyltransferase DY471_26285 ENOG41086DT Membrane protein of unknown function DY471_26295 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DY471_26315 ENOG4107TXC Transcriptional regulator DY471_26350 ENOG4105DUM transcriptional regulator, lysR family DY471_26360 ENOG4108WS4 fmn reductase DY471_26365 ENOG4105C5H ABC transporter DY471_26375 ENOG4105BZ1 (ABC) transporter DY471_26385 ENOG4105CN1 protease DY471_26390 ENOG4105CRP Part of the ABC transporter FtsEX involved in DY471_26395 ENOG4105CAK Cell division ATP-binding protein ftsE DY471_26415 ENOG4105MS2 ribosomal subunit Interface protein DY471_26420 ENOG4105VEQ Cold shock protein DY471_26425 ENOG41081UC Inherit from COG: Competence protein DY471_26440 ENOG4105KVH Transcriptional regulator DY471_26450 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DY471_26455 ENOG4108KGH TRANSCRIPTIONal DY471_26460 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DY471_26465 ENOG4105C6Y Udp-glucose 6-dehydrogenase DY471_26470 ENOG4105ESV Glycosyl transferase, family 4 DY471_26480 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY471_26500 ENOG4105F8D glycoside hydrolase family 4 DY471_26505 ENOG4105VCP PTS System DY471_26510 ENOG4105CK1 PTS System DY471_26520 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DY471_26530 ENOG4105VCP PTS System DY471_26540 ENOG4105VZJ PTS System DY471_26555 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DY471_26560 ENOG4105ECB domain protein DY471_26565 ENOG4107RSM transcriptional regulator DY471_26595 ENOG4105DAA L-lactate DY471_26605 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DY471_26620 ENOG4105E0M Sulfatase DY471_26645 ENOG4107R8N Glycosyl transferase, family 2 DY471_26650 ENOG4105C94 Transporter DY471_26660 ENOG41069ER domain protein DY471_26670 ENOG4105KBK Zinc finger, swim domain protein DY471_26675 ENOG4105C0D helicase DY471_26705 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY471_26715 ENOG4107RBB ABC transporter, permease DY471_26720 ENOG4105C19 ABC transporter DY471_26740 ENOG4105CXY transporter DY471_26755 ENOG4105BZU Histidine kinase DY471_26760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_26765 ENOG4105CMR udp-glucose 4-epimerase DY471_26790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DY471_26795 ENOG4105EY8 ABC transporter DY471_26805 ENOG4107SJB teichoic acid biosynthesis DY471_26815 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) DY471_26820 ENOG4107SJB teichoic acid biosynthesis DY471_26825 ENOG4107RZX Teichoic acid biosynthesis protein DY471_26830 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DY471_26840 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DY471_26850 ENOG4105FRN stage II sporulation protein DY471_26865 ENOG4105DY9 regulatoR DY471_26885 ENOG4106778 Protein of unknown function (DUF1146) DY471_26890 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY471_26895 ENOG4105C8S subunit m DY471_26900 ENOG4105D65 subunit l DY471_26930 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY471_26940 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY471_26945 ENOG4105BZU Histidine kinase DY471_26995 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DY471_27000 ENOG41062M3 atp synthase DY471_27030 ENOG4108YZG isomerase DY471_27045 ENOG4108VGI doxx family DY471_27050 ENOG4107XC4 flavin reductase domain protein, FMN-binding DY471_27065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DY471_27075 ENOG4108ZXQ stage ii sporulation protein r DY471_27080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DY471_27085 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DY471_27105 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DY471_27110 ENOG4105CBT Fructose-1,6-bisphosphatase DY471_27115 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DY471_27150 ENOG4105C1G acyl-Coa dehydrogenase DY471_27155 ENOG4105C1G acyl-Coa dehydrogenase DY471_27160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DY471_27170 ENOG4105DF6 Fe-S oxidoreductase DY471_27185 ENOG4105BZU Histidine kinase DY471_27210 ENOG4105BZU Histidine kinase DY471_27215 ENOG4105KCT ABC transporter DY471_27220 ENOG4108M15 ABC transporter DY471_27225 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DY471_27235 ENOG4105IIU Aminopeptidase DY471_27255 ENOG4105EMN RNA polymerase sigma factor DY471_27265 ENOG410684U Domain of unknown function (DUF1934) DY471_27290 ENOG4105CYW agmatinase DY471_27300 ENOG4105DXB Major Facilitator superfamily DY471_27305 ENOG4107SWG transcriptional regulator MERR family DY471_27310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DY471_27315 ENOG4105BZ4 penicillin-binding protein DY471_27320 ENOG4108XFG YwhD family DY471_27325 ENOG4108Z4T Peptidase M50 DY471_27330 ENOG41069HH 4-oxalocrotonate tautomerase DY471_27335 ENOG4105DCI Phosphohydrolase DY471_27340 ENOG4108MES Periplasmic binding protein DY471_27345 ENOG4105E0A ABC, transporter DY471_27350 ENOG4105EHG Permease protein DY471_27355 ENOG4105DQ5 transport system permease protein DY471_27365 ENOG4108VCI transcription factor, rsfa family DY471_27380 ENOG4108IJ2 phosphate acetyltransferase DY471_27395 ENOG4108VKI Cell wall hydrolase DY471_27415 ENOG4107SVH Potassium channel protein DY471_27425 ENOG410667J hydrolase DY471_27430 ENOG4105VCH membrane DY471_27440 ENOG4108TU7 Inherit from COG: (ABC) transporter DY471_27445 ENOG4105CJ1 ABC, transporter DY471_27450 ENOG41090WU lipolytic protein G-D-S-L family DY471_27465 ENOG4105D6E homoserine dehydrogenase DY471_27490 ENOG4108Y4K DNA-binding transcriptional activator DY471_27500 ENOG4105WH1 Two component transcriptional regulator luxr family DY471_27505 ENOG4105BZU Histidine kinase DY471_27510 ENOG4105DWF phosphomethylpyrimidine kinase DY471_27515 ENOG4105BZU Histidine kinase DY471_27520 ENOG4105VCD cytoplasmic protein DY471_27525 ENOG4105D22 carbon starvation protein DY471_27530 ENOG4105DY9 regulatoR DY471_27535 ENOG41079KZ Major Facilitator Superfamily DY471_27555 ENOG4105EN6 Membrane DY471_27560 ENOG4106YBV Methyl-accepting chemotaxis DY471_27570 ENOG4108S4H thioesterase Superfamily protein DY471_27580 ENOG4105JEU Glycosyl transferase, family 2 DY471_27585 ENOG4105C5H ABC transporter DY471_27595 ENOG41067SE Tetr family transcriptional regulator DY471_27605 ENOG4105E0X reductase DY471_27610 ENOG4106F5Q Membrane DY471_27625 ENOG4105DY9 regulatoR DY471_27630 ENOG4108HRK Histidine kinase DY471_27635 ENOG4107RGD Major Facilitator superfamily DY471_27655 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY471_27665 ENOG4105IW1 AmiS UreI transporter DY471_27675 ENOG4105CMR udp-glucose 4-epimerase DY471_27680 ENOG4108UT2 hemolysin iii DY471_27690 ENOG4105C1J atp-dependent rna helicase DY471_27700 ENOG4105DPN Oligoendopeptidase f DY471_27720 ENOG4105C0H protease DY471_27725 ENOG4105Q2H domain protein DY471_27740 ENOG4105BZU Histidine kinase DY471_27745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY471_27775 ENOG4105CDU Replicative dna helicase DY471_27785 ENOG4105BZR domain protein DY471_27790 ENOG4108XMW Membrane DY471_27800 ENOG4108UUM single-stranded DNA-binding protein DY471_27810 ENOG4105C3G gtp-binding protein DY471_27815 ENOG4105VDK protein, conserved in bacteria DY471_27820 ENOG4105D8X mechanosensitive ion channel DY471_27825 ENOG4108ZDA Sporulation protein YyaC DY471_27830 ENOG4105FA0 parb-like partition protein DY471_27835 ENOG4107QJE Chromosome Partitioning Protein DY471_27865 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DY471_27885 ENOG4108C33 Resolvase DY471_27985 ENOG4105XSJ toxin secretion phage lysis holin DY471_28015 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DY471_28055 ENOG4108NJY Repeat protein DY471_28060 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY471_28105 ENOG4107QJE Chromosome Partitioning Protein DY471_28135 ENOG4108JJA ABC, transporter DY471_28145 ENOG4105W1Y Transcriptional regulator DY471_28225 ENOG4105WXW Antirepressor DY471_28245 ENOG4106CVF DNA replication protein DY471_28285 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DY471_28300 ENOG4105CNU cell division protein FtsK