locus-tag class description DY470_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DY470_00015 ENOG410848D S4 domain protein YaaA DY470_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY470_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DY470_00100 ENOG4105ZMH deoxynucleoside kinase DY470_00110 ENOG4105GTG Isochorismatase DY470_00115 ENOG4108Z6B deaminase DY470_00125 ENOG4105C6E dna polymerase iii DY470_00180 ENOG4105CXN decarboxylase DY470_00190 ENOG4105FA2 dna polymerase iii DY470_00195 ENOG4105MA4 psp1 domain protein DY470_00205 ENOG41060K3 Methyltransferase DY470_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DY470_00220 ENOG4105KRN Transcriptional regulator, abrb family DY470_00230 ENOG4105F8V Hydrolase, tatD family DY470_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DY470_00245 ENOG4105XFA sporulation peptidase YabG DY470_00250 ENOG4105W42 Veg protein DY470_00265 ENOG4105DFT pur operon repressor DY470_00270 ENOG4105KME endoribonuclease L-psp DY470_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DY470_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DY470_00300 ENOG4108JA2 transcriptioN-repair coupling factor DY470_00305 ENOG4108M14 stage v sporulation protein t DY470_00315 ENOG4108IY2 MazG family DY470_00320 ENOG41082I2 s4 domain protein DY470_00325 ENOG4105VYY sporulation protein yabp DY470_00340 ENOG41060GV RNA binding s1 domain protein DY470_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase DY470_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DY470_00385 ENOG4105C6T cysteine synthase DY470_00390 ENOG4105CRQ synthase (Component I) DY470_00395 ENOG4105DDQ anthranilate synthase DY470_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DY470_00405 ENOG4105EEI dihydropteroate synthase DY470_00410 ENOG4105KRF dihydroneopterin aldolase DY470_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DY470_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DY470_00515 ENOG4108Z0C Uvrb UvrC protein DY470_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DY470_00540 ENOG4105CTP PilT protein domain protein DY470_00560 ENOG4105D7W serine acetyltransferase DY470_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 DY470_00580 ENOG4105M0M Tetracycline resistance protein DY470_00585 ENOG4105QIV RNA polymerase DY470_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DY470_00625 ENOG4107Y49 methyltransferase DY470_00640 ENOG4105XPM ribosomal protein DY470_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DY470_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DY470_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DY470_00790 ENOG41067V7 50S ribosomal protein L36 DY470_00820 ENOG4108JJB ABC transporter DY470_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DY470_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DY470_00855 ENOG4105D1F ATP-binding protein DY470_00870 ENOG4108NMV polysaccharide deacetylase DY470_00950 ENOG4105C8B TIGR00159 family DY470_00955 ENOG4107U5W ybbr family DY470_00975 ENOG4108VQT Alpha beta hydrolase fold protein DY470_00985 ENOG4105CMG Carbohydrate kinase DY470_00995 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DY470_01005 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DY470_01035 ENOG4108PSK reductase DY470_01040 ENOG4108UMI ABC transporter, permease DY470_01045 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DY470_01050 ENOG4105D01 (LipO)protein DY470_01055 ENOG4105EE1 crotonyl-CoA reductase DY470_01065 ENOG4105IQ5 FAD linked oxidase domain protein DY470_01080 ENOG4105C2C drug resistance transporter, Bcr CflA DY470_01095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY470_01100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY470_01105 ENOG4105C3U ABC transporter DY470_01110 ENOG4108JQ7 (ABC) transporter DY470_01135 ENOG4105U5Y Transcriptional regulator DY470_01145 ENOG4108J59 Extracellular solute-binding protein, family 5 DY470_01150 ENOG4108J59 Extracellular solute-binding protein, family 5 DY470_01160 ENOG4105II7 pyrroline-5-carboxylate reductase DY470_01165 ENOG4107XDY Nicotinamide Mononucleotide Transporter DY470_01175 ENOG4105E0C molybdate abc transporter DY470_01180 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DY470_01185 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DY470_01215 ENOG4105F6E Acyl-transferase DY470_01235 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DY470_01245 ENOG4108RE7 deoxyribonuclease DY470_01285 ENOG4105C5H ABC transporter DY470_01295 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DY470_01300 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DY470_01310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY470_01315 ENOG4105C3U ABC transporter DY470_01320 ENOG4108JQ7 (ABC) transporter DY470_01325 ENOG410667J hydrolase DY470_01355 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DY470_01360 ENOG4105ERH Fumarylacetoacetate hydrolase DY470_01375 ENOG4105CPF Cell wall formation (By similarity) DY470_01380 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DY470_01395 ENOG4107ZXI Rhomboid family DY470_01405 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DY470_01410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DY470_01420 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DY470_01520 ENOG4105K8N protein family UPF0079, ATPase DY470_01525 ENOG41072GX Peptidase M22 Glycoprotease DY470_01530 ENOG410801F ribosomal-protein-alanine acetyltransferase DY470_01540 ENOG4105C5H ABC transporter DY470_01555 ENOG4108TYN CAAX amino terminal protease family protein DY470_01575 ENOG4105C7N Xanthine uracil vitamin C permease DY470_01585 ENOG4105BZU Histidine kinase DY470_01615 ENOG4107ZXU DSBA oxidoreductase DY470_01695 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY470_01715 ENOG4105SX7 Transporter DY470_01745 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DY470_01750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DY470_01755 ENOG4105C83 adenylosuccinate lyase DY470_01765 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DY470_01790 ENOG4108V3E phosphoribosylglycinamide formyltransferase DY470_01800 ENOG4105C12 Phosphoribosylglycinamide synthetase DY470_01830 ENOG4105C4R Atp-dependent dna helicase DY470_01855 ENOG4108W2Y isochorismatase DY470_01865 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DY470_01870 ENOG4108UMI ABC transporter, permease DY470_01875 ENOG4105D01 (LipO)protein DY470_01895 ENOG410834F Transcriptional regulator DY470_01900 ENOG4107I77 yiaA/B two helix domain DY470_01920 ENOG4105CBD Diacylglycerol kinase DY470_01925 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DY470_01930 ENOG4108JPW Aminotransferase DY470_01940 ENOG4105C26 Dehydrogenase DY470_01945 ENOG4105KPY Small multidrug resistance protein DY470_01965 ENOG4105D9N nucleoside DY470_01970 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DY470_01980 ENOG4105BZU Histidine kinase DY470_01985 ENOG4108W15 Protein of unknown function (DUF1456) DY470_02005 ENOG4105DTQ mandelate racemase muconate lactonizing DY470_02015 ENOG4105DFD Na H antiporter DY470_02035 ENOG4105D3R alkyl hydroperoxide reductase DY470_02040 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DY470_02050 ENOG4107W7X Aldolase DY470_02055 ENOG4105EHG Permease protein DY470_02060 ENOG4105DQ5 transport system permease protein DY470_02065 ENOG4108V5C ABC transporter DY470_02095 ENOG4106UIA DY470_02100 ENOG4106UIA DY470_02120 ENOG4105BZU Histidine kinase DY470_02140 ENOG410756H nucleotidyltransferase DY470_02145 ENOG4105D2S major facilitator superfamily DY470_02160 ENOG4105E5Q amino acid AbC transporter DY470_02165 ENOG4105EAB amino acid AbC transporter DY470_02180 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY470_02205 ENOG4105C5B carbamate kinase DY470_02225 ENOG4105CI1 PTS System DY470_02255 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DY470_02270 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY470_02290 ENOG4105C5H ABC transporter DY470_02320 ENOG41062JF Transcriptional regulator DY470_02340 ENOG4105DEU major facilitator superfamily DY470_02370 ENOG4108N0M stress protein DY470_02375 ENOG4106FN3 tellurium resistance protein DY470_02380 ENOG4106FN3 tellurium resistance protein DY470_02385 ENOG4107TS3 membrane protein, TerC DY470_02390 ENOG4108TTB tellurium resistance protein DY470_02425 ENOG4105KJF protein tyrosine phosphatase DY470_02435 ENOG4107U9T Pfam:Ribonuclease_BN DY470_02440 ENOG4105C59 p-type ATPase DY470_02445 ENOG4108IPJ Membrane DY470_02470 ENOG4107ZTW SNARE associated Golgi DY470_02485 ENOG410606W general stress protein DY470_02490 ENOG4105UPD Calcium Proton DY470_02525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DY470_02530 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DY470_02540 ENOG4108JUB Transcriptional regulator DY470_02550 ENOG4108IQI permease DY470_02575 ENOG4105CSV Glutaminase DY470_02590 ENOG4108A04 Beta-lactamase DY470_02610 ENOG4105CKK Glycosyl transferase, family 2 DY470_02615 ENOG4107QQG Dehydrogenase DY470_02620 ENOG4105C3I Nad-dependent epimerase dehydratase DY470_02640 ENOG4105F1A Pyruvate formate-lyase DY470_02660 ENOG4105CI2 imidazolone-5-propionate hydrolase DY470_02665 ENOG4105ECP epimerase DY470_02695 ENOG41067AE Membrane-bound metal-dependent hydrolase DY470_02700 ENOG4105CEN a g-specific adenine glycosylase DY470_02705 ENOG4106BXE DY470_02725 ENOG4105BZ1 (ABC) transporter DY470_02730 ENOG4107NBY Membrane DY470_02735 ENOG4105CBC glutamate synthase DY470_02745 ENOG4108IUW ABC transporter DY470_02760 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DY470_02765 ENOG4105G5W regulator Fur family DY470_02880 ENOG4108JQC penicillin-binding protein 1A DY470_02885 ENOG4107ZQN disulfide bond DY470_02895 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DY470_02905 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DY470_02910 ENOG4105BZU Histidine kinase DY470_02915 ENOG4105CYN Serine protein kinase DY470_02935 ENOG4105C94 Transporter DY470_02950 ENOG4105DZ6 Band 7 protein DY470_02960 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DY470_02965 ENOG4108V9W transcriptional regulatory protein DY470_02970 ENOG4105D4T Citrate transporter DY470_02990 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DY470_02995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY470_03000 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DY470_03005 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DY470_03010 ENOG4105BZ7 extracellular solute-binding protein family 1 DY470_03015 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DY470_03020 ENOG4108STX response regulator DY470_03025 ENOG4105US7 Histidine kinase DY470_03050 ENOG4108MRH transcriptional regulatory protein DY470_03060 ENOG4105C6K Malic enzyme DY470_03070 ENOG4108UZ3 Transporter DY470_03075 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY470_03085 ENOG4105BZU Histidine kinase DY470_03090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_03095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DY470_03100 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DY470_03105 ENOG4108JB9 formate dehydrogenase DY470_03125 ENOG4105CUB amino acid DY470_03135 ENOG4105C59 p-type ATPase DY470_03140 ENOG4105DAP Nicotinate phosphoribosyltransferase DY470_03170 ENOG41073R8 VanW family DY470_03175 ENOG4108KGH TRANSCRIPTIONal DY470_03180 ENOG4105D9N nucleoside DY470_03185 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DY470_03190 ENOG4105C37 (CBS) domain DY470_03195 ENOG4108IJ0 Aspartate ammonia-lyase DY470_03200 ENOG4105DAA L-lactate DY470_03215 ENOG4105DUX Transporter DY470_03220 ENOG4108MES Periplasmic binding protein DY470_03225 ENOG4105DQ5 transport system permease protein DY470_03230 ENOG4108IHU transport system permease protein DY470_03235 ENOG4105E0A ABC, transporter DY470_03240 ENOG4105DMQ Methyltransferase DY470_03250 ENOG4105EXW epimerase dehydratase DY470_03255 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DY470_03265 ENOG4107T89 von Willebrand factor, type A DY470_03270 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DY470_03275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY470_03285 ENOG4105BZU Histidine kinase DY470_03290 ENOG4105D5Q Arginine ornithine antiporter DY470_03295 ENOG4107414 GntR family transcriptional regulator DY470_03300 ENOG4105C5Y PTS System DY470_03305 ENOG4105CG3 alpha amylase, catalytic region DY470_03320 ENOG4105E1K spore germination protein DY470_03330 ENOG4105CRN Aminoglycoside phosphotransferase DY470_03335 ENOG4105BZG amino acid carrier protein DY470_03340 ENOG4105CDA abc transporter atp-binding protein DY470_03345 ENOG4105CT1 (ABC) transporter DY470_03350 ENOG4105EAD ABC transporter DY470_03355 ENOG4105DRP amino acid AbC transporter DY470_03360 ENOG4108IQI permease DY470_03390 ENOG4105NAE bifunctional deaminase-reductase domain protein DY470_03395 ENOG4105BZU Histidine kinase DY470_03410 ENOG4105CHH sulfate transporter DY470_03415 ENOG41068KF Universal stress protein DY470_03425 ENOG4105DEF Extracellular solute-binding protein, family 5 DY470_03435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY470_03440 ENOG4108JQ7 (ABC) transporter DY470_03450 ENOG4105CXY transporter DY470_03455 ENOG41067TZ transcriptional regulator, MarR family DY470_03460 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_03465 ENOG4105ETE Transcriptional regulator (LacI family DY470_03470 ENOG4108RVA ribokinase DY470_03480 ENOG4105C2J ABC transporter DY470_03490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DY470_03495 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DY470_03555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY470_03560 ENOG41069ER domain protein DY470_03565 ENOG4105VZ8 Transcriptional regulator DY470_03570 ENOG4107D63 DY470_03580 ENOG4105DUX Transporter DY470_03600 ENOG4105C85 amino acid DY470_03605 ENOG4105C7N Xanthine uracil vitamin C permease DY470_03620 ENOG4105MA6 gCN5-related N-acetyltransferase DY470_03645 ENOG4105BZ9 Cytochrome C oxidase, subunit I DY470_03650 ENOG4105E2S oxidase) subunit II DY470_03670 ENOG4106CAD Protein of unknown function (DUF3311) DY470_03690 ENOG4108NHD germination protein DY470_03695 ENOG4105CE1 Ferrous iron transport protein b DY470_03700 ENOG4105CE1 Ferrous iron transport protein b DY470_03705 ENOG4105CE1 Ferrous iron transport protein b DY470_03710 ENOG4105CVA phosphate DY470_03715 ENOG4105C8U phosphate abc transporter DY470_03720 ENOG4105E2Z phosphate ABC transporter (Permease DY470_03845 ENOG41080XQ Signal transduction protein with cbs domains DY470_03865 ENOG4105ETU transcriptional activator (TenA DY470_03875 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DY470_03885 ENOG4108VEU Thiamine monophosphate synthase DY470_03890 ENOG41080HI glycine oxidase DY470_03905 ENOG4105D06 uba thif-type nad fad binding protein DY470_03910 ENOG4105DWF phosphomethylpyrimidine kinase DY470_03960 ENOG4108INS Transcriptional regulator DY470_03985 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DY470_03995 ENOG4105C7N Xanthine uracil vitamin C permease DY470_04005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DY470_04040 ENOG4108B31 Spore germination protein DY470_04060 ENOG4107Y03 Nitroreductase DY470_04065 ENOG4105ED1 spovr family DY470_04090 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DY470_04095 ENOG4105XTG Pfam:DUF156 DY470_04100 ENOG4105VFE sira family DY470_04105 ENOG4107TPS domain protein DY470_04110 ENOG4105VFE sira family DY470_04115 ENOG41085GJ domain protein DY470_04125 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DY470_04130 ENOG41087NI Sulfite exporter TauE/SafE DY470_04140 ENOG4108KGH TRANSCRIPTIONal DY470_04165 ENOG4105EMD TRANSCRIPTIONal DY470_04170 ENOG4105VCP PTS System DY470_04175 ENOG4105VZJ PTS System DY470_04195 ENOG41069ER domain protein DY470_04200 ENOG4107RBB ABC transporter, permease DY470_04205 ENOG4105C19 ABC transporter DY470_04240 ENOG4105WEF catalase DY470_04275 ENOG4107T5V SNARE associated Golgi DY470_04305 ENOG4105CUB amino acid DY470_04310 ENOG4107RWR Sodium hydrogen exchanger DY470_04320 ENOG4106KNT transcriptional regulator DY470_04355 ENOG4108PCN EamA-like transporter family DY470_04360 ENOG4108YXU transcriptional regulator AsnC family DY470_04370 ENOG4105KPY Small multidrug resistance protein DY470_04375 ENOG4105KPY Small multidrug resistance protein DY470_04395 ENOG4105E5W Transporter DY470_04405 ENOG4107RKG DJ-1/PfpI family DY470_04410 ENOG4105CH6 catalase DY470_04420 ENOG4105D5Q Arginine ornithine antiporter DY470_04425 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DY470_04435 ENOG4105C26 Dehydrogenase DY470_04450 ENOG4105BZ1 (ABC) transporter DY470_04455 ENOG4105BZ1 (ABC) transporter DY470_04470 ENOG4105DRP amino acid AbC transporter DY470_04475 ENOG4105CDA abc transporter atp-binding protein DY470_04490 ENOG410839P DY470_04525 ENOG4107FQX Alpha-acetolactate decarboxylase DY470_04540 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY470_04545 ENOG4105D4P Coproporphyrinogen iii oxidase DY470_04565 ENOG4105CHH sulfate transporter DY470_04610 ENOG4106AKK s-layer domain-containing protein DY470_04620 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DY470_04630 ENOG4105CGU Enoyl-CoA hydratase DY470_04655 ENOG4105DER m42 family DY470_04675 ENOG4105CTU Proline racemase DY470_04715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY470_04725 ENOG4108JQ7 (ABC) transporter DY470_04735 ENOG4105CSH Transporter DY470_04745 ENOG4108MRH transcriptional regulatory protein DY470_04755 ENOG4105M6F mutator MutT protein DY470_04770 ENOG4105CFI type iii restriction protein res subunit DY470_04800 ENOG4105CDU Replicative dna helicase DY470_04830 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_04895 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DY470_04955 ENOG4105CMT Dihydroxyacetone kinase DY470_04970 ENOG4105CMT Dihydroxyacetone kinase DY470_04985 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DY470_05055 ENOG4105WN5 stage II sporulation protein DY470_05065 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_05075 ENOG4108MJI response regulator DY470_05080 ENOG4105BZU Histidine kinase DY470_05085 ENOG4105BZU Histidine kinase DY470_05105 ENOG4105K8R UPF0145 protein DY470_05140 ENOG4107VRP DNA repair exonuclease DY470_05145 ENOG4106D4I domain protein DY470_05155 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY470_05240 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DY470_05395 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY470_05415 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DY470_05480 ENOG4108MUZ hydrolase DY470_05500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DY470_05515 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DY470_05530 ENOG4105EMN RNA polymerase sigma factor DY470_05555 ENOG4105C57 major facilitator superfamily DY470_05560 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_05570 ENOG4105EEM helicase DY470_05575 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY470_05600 ENOG4105K59 histidine triad (HIT) protein DY470_05660 ENOG410905X membrane-flanked domain protein DY470_05665 ENOG4105CKV Membrane DY470_05710 ENOG410905X membrane-flanked domain protein DY470_05715 ENOG4105CKV Membrane DY470_05720 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DY470_05725 ENOG4105BZ4 penicillin-binding protein DY470_05740 ENOG4105C1Q protoporphyrinogen oxidase DY470_05770 ENOG4105ECB domain protein DY470_05790 ENOG4108MK9 spermidine N(1)-acetyltransferase DY470_05800 ENOG4106AXD DY470_05805 ENOG4108RQ5 Beta-lactamase domain-containing protein DY470_05810 ENOG4105DF9 Lipoate-protein, ligase DY470_05820 ENOG4105CEY Amp-dependent synthetase and ligase DY470_05840 ENOG4105CNA YD repeat protein DY470_05870 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) DY470_05875 ENOG4107RN3 metallophosphoesterase DY470_05880 ENOG4107TVP HD domain protein DY470_05890 ENOG4108AEY RNA polymerase sigma factor DY470_05900 ENOG41086D8 Transcriptional regulator DY470_05910 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY470_05930 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DY470_05950 ENOG4105ZU5 s-layer protein DY470_05955 ENOG4107QP3 malate synthase g DY470_05970 ENOG4105VEQ Cold shock protein DY470_05985 ENOG4105XVF Competence transcription factor DY470_06050 ENOG4105ERH Fumarylacetoacetate hydrolase DY470_06075 ENOG4105CAQ asparagine synthetase DY470_06080 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DY470_06085 ENOG4105CH6 catalase DY470_06090 ENOG4105BZU Histidine kinase DY470_06110 ENOG4105QNR S1 RNA binding domain protein DY470_06120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY470_06130 ENOG4107AYK membrAne DY470_06135 ENOG41073B9 DY470_06145 ENOG4108KP7 hydrolase DY470_06155 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DY470_06180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY470_06185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DY470_06200 ENOG4105C31 Tryptophanyl-tRNA synthetase DY470_06220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DY470_06225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DY470_06235 ENOG4108JQ7 (ABC) transporter DY470_06240 ENOG4105UQX Mate efflux family protein DY470_06260 ENOG4108ZCF integral membrane protein DY470_06270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY470_06280 ENOG4105DPN Oligoendopeptidase f DY470_06290 ENOG4108Z18 K06886 hemoglobin DY470_06295 ENOG4105MIX Adenylate cyclase DY470_06310 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DY470_06315 ENOG4105EMS pseudouridine synthase DY470_06335 ENOG4105K64 Glycosyl transferase, family 2 DY470_06355 ENOG4107TVC Glycosyl transferase, family 2 DY470_06375 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DY470_06380 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DY470_06390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DY470_06465 ENOG4105CK7 Sodium proline symporter DY470_06475 ENOG4105CRQ synthase (Component I) DY470_06480 ENOG4105DDQ anthranilate synthase DY470_06575 ENOG4105C7S Dehydrogenase DY470_06585 ENOG4105VZ8 Transcriptional regulator DY470_06635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY470_06650 ENOG4108IUX (ABC) transporter DY470_06655 ENOG4105RHA ABC transporter, permease DY470_06745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY470_06755 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DY470_06765 ENOG4105DZ1 carboxypeptidase DY470_06770 ENOG4105VFR signal peptidase DY470_06820 ENOG4105C26 Dehydrogenase DY470_06830 ENOG4105F38 ABC transporter, permease DY470_06835 ENOG4105D38 putrescine abc transporter DY470_06840 ENOG4107RUE extracellular solute-binding protein family 1 DY470_06850 ENOG4105EYF MMPL domain protein DY470_06860 ENOG4108YBP pseudouridine synthase DY470_06870 ENOG4105K4I Scp-like extracellular DY470_06875 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DY470_06880 ENOG4105CQB FAD linked oxidase domain protein DY470_06895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_06900 ENOG4105BZU Histidine kinase DY470_06905 ENOG4105JXH GntR family transcriptional regulator DY470_06925 ENOG4106A3R peptidase DY470_06935 ENOG4108QTI )-transporter DY470_06940 ENOG4107TS3 membrane protein, TerC DY470_06945 ENOG4105CZN Potassium uptake protein DY470_06950 ENOG410681C small acid-soluble spore protein DY470_06955 ENOG4108Z7G MaoC domain protein dehydratase DY470_06975 ENOG4105CHR reductase DY470_06985 ENOG4105MWK D-amino acid dehydrogenase, small subunit DY470_07005 ENOG4105C4Y ABC transporter DY470_07010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY470_07015 ENOG4107RCV ABC transporter, permease DY470_07035 ENOG4105E98 transcriptional regulator DeoR family DY470_07050 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DY470_07060 ENOG4105PXI polysaccharide deacetylase DY470_07070 ENOG4105BZU Histidine kinase DY470_07075 ENOG41090MY MarR family Transcriptional regulator DY470_07085 ENOG4106DF1 DY470_07090 ENOG4105BZU Histidine kinase DY470_07100 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DY470_07105 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DY470_07145 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DY470_07155 ENOG41079K6 HNH endonuclease DY470_07175 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DY470_07180 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DY470_07185 ENOG4105CZV ABC transporter DY470_07195 ENOG4105CJ1 ABC, transporter DY470_07235 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DY470_07240 ENOG4105EA8 2-Nitropropane dioxygenase DY470_07245 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DY470_07255 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DY470_07275 ENOG4105NQC Flavodoxin DY470_07300 ENOG4107QMU Mate efflux family protein DY470_07305 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DY470_07335 ENOG4105CZN Potassium uptake protein DY470_07340 ENOG41063Y9 DY470_07345 ENOG4105KBJ sporulation protein ytfj DY470_07370 ENOG4105CM2 brancheD-chain amino acid aminotransferase DY470_07375 ENOG4105C7K acetolactate synthase DY470_07380 ENOG4108ZP8 Acetolactate synthase small subunit DY470_07455 ENOG4107RVV histidinol phosphate phosphatase, hisj family DY470_07470 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DY470_07475 ENOG4105E0M Sulfatase DY470_07485 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DY470_07505 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DY470_07510 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DY470_07520 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DY470_07525 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DY470_07530 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DY470_07535 ENOG4105C8J )-transporter DY470_07555 ENOG4105DFD Na H antiporter DY470_07575 ENOG4105ENE Histidine kinase DY470_07580 ENOG4105WH1 Two component transcriptional regulator luxr family DY470_07600 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DY470_07645 ENOG4105CJ3 phosphate transporter DY470_07650 ENOG4107GRR phosphate transport regulator DY470_07655 ENOG4105BZ4 penicillin-binding protein DY470_07670 ENOG4105BZU Histidine kinase DY470_07675 ENOG4105I3N Conserved Protein DY470_07690 ENOG4105BZU Histidine kinase DY470_07735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY470_07740 ENOG4105DZ1 carboxypeptidase DY470_07745 ENOG4108JIC nucleoside recognition domain protein DY470_07755 ENOG4105FE9 pseudouridine synthase DY470_07765 ENOG4107TWT Cytochrome c biogenesis protein DY470_07770 ENOG4105CRE cytochrome C DY470_07775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_07780 ENOG4105BZU Histidine kinase DY470_07785 ENOG4108WBT adenosyltransferase DY470_07790 ENOG41063SB peptidase DY470_07800 ENOG4108SAX Membrane DY470_07815 ENOG4105C9U ATP-dependent DNA helicase RecQ DY470_07820 ENOG4105I7S Abortive infection protein DY470_07830 ENOG4107RGJ metallophosphoesterase DY470_07835 ENOG4107X2D transcriptional regulator, merr family DY470_07840 ENOG4108S6Z Negative regulator of genetic competence DY470_07865 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DY470_07870 ENOG4105HDK L-asparaginase DY470_07900 ENOG4105S2F DY470_07905 ENOG41065D1 DY470_07935 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DY470_07950 ENOG4105XXQ heptaprenyl diphosphate synthase component I DY470_07960 ENOG4105EAH synthase DY470_07985 ENOG41068YB TPR repeat-containing protein DY470_08000 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DY470_08005 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DY470_08010 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DY470_08040 ENOG4108JYZ YitT family DY470_08050 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DY470_08065 ENOG4105FJR Lmbe family DY470_08070 ENOG4105CPK Glycosyl transferase (Group 1 DY470_08105 ENOG4105DVT helicase DY470_08110 ENOG4105YAC DY470_08130 ENOG4105CSM endonuclease III DY470_08140 ENOG4105BZ4 penicillin-binding protein DY470_08195 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DY470_08205 ENOG4105DVT helicase DY470_08210 ENOG4105CTD carboxy-peptidase DY470_08225 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DY470_08235 ENOG4105C2W permease DY470_08240 ENOG4105DHF Membrane DY470_08245 ENOG410890F Dynamin family DY470_08255 ENOG4108W0I acetyltransferase DY470_08265 ENOG4105KHC sulfurtransferase DY470_08300 ENOG4106032 Glutathionylspermidine synthase DY470_08330 ENOG4108SZE gCN5-related N-acetyltransferase DY470_08350 ENOG41081VK Ribonuclease DY470_08415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY470_08425 ENOG4107RWR Sodium hydrogen exchanger DY470_08430 ENOG4105CN5 Metallo-Beta-Lactamase DY470_08435 ENOG4108Z5V transcriptional regulator, merr family DY470_08445 ENOG4105H67 Protein of unknown function (DUF421) DY470_08450 ENOG41080C8 DUF218 domain DY470_08505 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DY470_08515 ENOG4107R0U MotA TolQ exbB proton channel DY470_08520 ENOG4105ER2 Ompa motb domain protein DY470_08525 ENOG4107YTP response regulator receiver protein DY470_08530 ENOG4105CBS Chea signal transduction histidine kinase DY470_08535 ENOG4105DD5 Flagellar motor switch protein DY470_08550 ENOG4105BZU Histidine kinase DY470_08570 ENOG4105E1Q flagellar hook-associated protein DY470_08575 ENOG4105DTJ flagellar hook-associated protein DY470_08580 ENOG4107TPX flagellar hook-associated DY470_08595 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DY470_08600 ENOG4108ZC9 flagellar basal-body rod protein flgc DY470_08605 ENOG41075Z6 flagellar hook-basal body complex protein fliE DY470_08610 ENOG4107U2N Flagellar M-ring protein DY470_08615 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DY470_08645 ENOG4105BZE flagellar hook protein, FlgE DY470_08660 ENOG4107R88 Chemotaxis protein (CheV) DY470_08675 ENOG4105I03 Flagellin DY470_08680 ENOG4105I03 Flagellin DY470_08685 ENOG4105E4C Lytic transglycosylase catalytic DY470_08695 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DY470_08700 ENOG4105DD5 Flagellar motor switch protein DY470_08710 ENOG4105CN7 Flagellar biosynthetic protein FliP DY470_08715 ENOG4105VS8 Flagellar biosynthetic protein fliq DY470_08725 ENOG4105D00 flagellar biosynthetic protein flhB DY470_08730 ENOG4105D7B Flagellar biosynthesis protein flha DY470_08735 ENOG4105FZW flagellar biosynthesis regulator FlhF DY470_08740 ENOG4105KTQ flagellar basal-body rod protein DY470_08745 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY470_08770 ENOG41062JF Transcriptional regulator DY470_08790 ENOG4105KAC Antibiotic biosynthesis monooxygenase DY470_08815 ENOG4105DUM transcriptional regulator, lysR family DY470_08820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DY470_08825 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DY470_08830 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DY470_08835 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DY470_08885 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DY470_08895 ENOG4105K56 Transcriptional regulator DY470_08905 ENOG4105CAQ asparagine synthetase DY470_08940 ENOG4105PGM cation diffusion facilitator family transporter DY470_08950 ENOG4105DRR Transcriptional regulator, GntR family DY470_08955 ENOG4108UZ3 Transporter DY470_08960 ENOG4105CKI cobalamin synthesis protein DY470_08970 ENOG4108PJD permease DY470_08985 ENOG4105DFD Na H antiporter DY470_08990 ENOG4105C9Q fumarate hydratase class II DY470_09010 ENOG4107QJQ Mate efflux family protein DY470_09015 ENOG4105EC3 peptidase S51, dipeptidase E DY470_09035 ENOG4107QIV Cytochrome c biogenesis protein DY470_09065 ENOG4106BRA Membrane DY470_09105 ENOG4105CJ1 ABC, transporter DY470_09125 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DY470_09135 ENOG4108IJ0 Aspartate ammonia-lyase DY470_09140 ENOG4105C6K Malic enzyme DY470_09205 ENOG4105FVX DY470_09245 ENOG4105CSR polyphosphate kinase 2 DY470_09250 ENOG4105DXI Major Facilitator superfamily DY470_09265 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DY470_09275 ENOG4105EU0 Major facilitator Superfamily DY470_09280 ENOG4105C6T cysteine synthase DY470_09300 ENOG4105C8J )-transporter DY470_09310 ENOG4105X5K response regulator receiver protein DY470_09315 ENOG4105H67 Protein of unknown function (DUF421) DY470_09330 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DY470_09335 ENOG4105E3B Multicopper oxidase DY470_09345 ENOG4105BZU Histidine kinase DY470_09350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_09355 ENOG4105CHR reductase DY470_09360 ENOG4105CM2 brancheD-chain amino acid aminotransferase DY470_09365 ENOG4105C7K acetolactate synthase DY470_09370 ENOG4108ZP8 Acetolactate synthase small subunit DY470_09375 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DY470_09385 ENOG4105C7B Threonine dehydratase DY470_09410 ENOG4105C6X Major Facilitator DY470_09415 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DY470_09425 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase DY470_09430 ENOG4105DY9 regulatoR DY470_09435 ENOG4105CYC Transferase DY470_09495 ENOG41068WN DY470_09515 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DY470_09520 ENOG4105C72 UPF0176 protein DY470_09530 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DY470_09535 ENOG4105C0X amino acid DY470_09560 ENOG4107RHR regulatoR DY470_09570 ENOG4105D9N nucleoside DY470_09575 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DY470_09605 ENOG4107RAQ aminopeptidase DY470_09610 ENOG4107STQ Multicopper oxidase DY470_09660 ENOG4108T5E Copper resistance protein DY470_09665 ENOG4105KTB nuclear export factor GLE1 DY470_09670 ENOG4107RT3 EamA-like transporter family DY470_09675 ENOG4105GZI Transcriptional regulator DY470_09680 ENOG4108Z40 Transcriptional regulator DY470_09685 ENOG4107ZXU DSBA oxidoreductase DY470_09690 ENOG4108TVJ Nitroreductase DY470_09695 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY470_09700 ENOG4106F5Q Membrane DY470_09710 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DY470_09720 ENOG4105CKI cobalamin synthesis protein DY470_09740 ENOG4108Z7G MaoC domain protein dehydratase DY470_09745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY470_09755 ENOG4105C0Z ABC transporter DY470_09760 ENOG4108IV0 ABC, transporter DY470_09765 ENOG4105C32 Amino acid ABC transporter (Permease) DY470_09775 ENOG4105SKE transcriptional Regulator LysR family DY470_09785 ENOG41090U3 tautomerase DY470_09805 ENOG4105C4M (Ubiquinol oxidase) subunit I DY470_09810 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DY470_09815 ENOG4108JJ9 ABC, transporter DY470_09820 ENOG4108JJ8 (ABC) transporter DY470_09865 ENOG4105BZ1 (ABC) transporter DY470_09870 ENOG4105EFI regulatoR DY470_09875 ENOG4105BZU Histidine kinase DY470_09890 ENOG4108VQJ O-methyltransferase DY470_09895 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DY470_09900 ENOG4108ZJ4 polysaccharide deacetylase DY470_09905 ENOG4106AKJ DY470_09925 ENOG4105D6E homoserine dehydrogenase DY470_09950 ENOG4108KGH TRANSCRIPTIONal DY470_09960 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY470_09965 ENOG4105BZU Histidine kinase DY470_09970 ENOG4107VMI polysaccharide deacetylase DY470_09980 ENOG4105KT7 mgtC SapB transporter DY470_09985 ENOG4105VRR gCN5-related N-acetyltransferase DY470_09995 ENOG4105DUU IucA IucC family protein DY470_10000 ENOG4105CEY Amp-dependent synthetase and ligase DY470_10015 ENOG4108WBH protein TIM barrel DY470_10020 ENOG4105YWU small acid-soluble spore protein DY470_10030 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DY470_10080 ENOG4105KRN Transcriptional regulator, abrb family DY470_10090 ENOG4105YVS arsR family transcriptional regulator DY470_10095 ENOG4107SET aldo keto reductase DY470_10100 ENOG4107XZQ multidrug resistance protein DY470_10125 ENOG4105C8Q Methyl-accepting chemotaxis DY470_10140 ENOG4108K88 Membrane DY470_10145 ENOG4108WPJ Ferritin-like domain DY470_10160 ENOG4105DEN Luciferase family DY470_10180 ENOG4107QM2 Aldo Keto reductase DY470_10185 ENOG4105CKI cobalamin synthesis protein DY470_10205 ENOG4105DSE periplasmic solute binding protein DY470_10210 ENOG4105K4T epimerase DY470_10220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DY470_10245 ENOG4105CVJ phosphoglycerate mutase DY470_10265 ENOG4107T5V SNARE associated Golgi DY470_10280 ENOG4108PJD permease DY470_10290 ENOG4108S4H thioesterase Superfamily protein DY470_10300 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DY470_10320 ENOG4105SXS Protein of unknown function (DUF456) DY470_10325 ENOG4105C37 (CBS) domain DY470_10345 ENOG4108Z7R Chaperone CsaA DY470_10365 ENOG4108ZRV stage ii sporulation protein p DY470_10375 ENOG4108VXD carboxy-peptidase DY470_10385 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DY470_10405 ENOG4105EFA 4-hydroxyphenylacetate DY470_10415 ENOG4105U1N riboflavin DY470_10430 ENOG4105KME endoribonuclease L-psp DY470_10460 ENOG41069HH 4-oxalocrotonate tautomerase DY470_10470 ENOG4108X4Q Hydrolase DY470_10480 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DY470_10485 ENOG4107UWY Methyltransferase DY470_10500 ENOG41087PP glycosyltransferase MGT family DY470_10505 ENOG4108JYZ YitT family DY470_10510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY470_10540 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DY470_10630 ENOG4105KBJ sporulation protein ytfj DY470_10655 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DY470_10675 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DY470_10680 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DY470_10690 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DY470_10695 ENOG4105EMN RNA polymerase sigma factor DY470_10720 ENOG4105CNW domain protein DY470_10730 ENOG4108V06 Glutathione peroxidase DY470_10745 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY470_10755 ENOG4108IUE nitrate reductase beta subunit DY470_10760 ENOG4105R3A Nitrate reductase DY470_10770 ENOG4107V6Q Cyclic nucleotide-binding domain DY470_10775 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DY470_10780 ENOG4105D06 uba thif-type nad fad binding protein DY470_10785 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY470_10790 ENOG4108ZAF Molybdopterin DY470_10810 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DY470_10815 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DY470_10820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DY470_10825 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DY470_10830 ENOG4108IFG nitrite reductase, (NAD(P)H) DY470_10835 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DY470_10860 ENOG4105MCT stage V sporulation protein S DY470_10885 ENOG4105C5H ABC transporter DY470_10900 ENOG4108UUM single-stranded DNA-binding protein DY470_10930 ENOG4107YX5 Pfam:DUF548 DY470_10960 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DY470_10975 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DY470_10980 ENOG4105C5S asparaginyl-tRNA synthetase DY470_11000 ENOG4105EC2 ftsk spoIIIe DY470_11080 ENOG4105BZW Glycerate kinase DY470_11085 ENOG4107QPK )-transporter DY470_11090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_11095 ENOG41062D9 Histidine kinase DY470_11110 ENOG4105C8J )-transporter DY470_11130 ENOG4107XGZ Hydrolase DY470_11135 ENOG4105CY2 Citrate transporter DY470_11140 ENOG4105C0A alcohol dehydrogenase DY470_11155 ENOG4105KD7 acetyltransferase DY470_11160 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DY470_11185 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DY470_11205 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) DY470_11210 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DY470_11220 ENOG4107RVG penicillin-binding protein DY470_11230 ENOG4105E9Q Acyl-transferase DY470_11235 ENOG4108UT2 hemolysin iii DY470_11245 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DY470_11255 ENOG4108RCR degv family DY470_11260 ENOG4105E8R UPF0173 metal-dependent hydrolase DY470_11265 ENOG4108KF3 Electron transport protein SCO1 SenC DY470_11270 ENOG4107Y70 Heat shock protein DY470_11275 ENOG4105CAQ asparagine synthetase DY470_11295 ENOG4108MES Periplasmic binding protein DY470_11300 ENOG4105F0I Aminotransferase DY470_11325 ENOG4107Y70 Heat shock protein DY470_11330 ENOG4105D8X mechanosensitive ion channel DY470_11335 ENOG4105BZU Histidine kinase DY470_11340 ENOG4105WH1 Two component transcriptional regulator luxr family DY470_11375 ENOG4105CMG Carbohydrate kinase DY470_11380 ENOG4105CMG Carbohydrate kinase DY470_11410 ENOG4108IJ8 ABC transporter DY470_11415 ENOG4105E90 ABC transporter DY470_11450 ENOG4105C37 (CBS) domain DY470_11475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY470_11490 ENOG4107S4Y M20 DapE family protein YgeY DY470_11495 ENOG4108TSC N-acetyltransferase DY470_11500 ENOG4108JUB Transcriptional regulator DY470_11510 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DY470_11550 ENOG4108N23 SpoOM-related protein DY470_11555 ENOG410841Q phosphoesterase PA-phosphatase related protein DY470_11565 ENOG4105SZ6 Thioredoxin DY470_11635 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DY470_11695 ENOG4105BZ4 penicillin-binding protein DY470_11700 ENOG4105CZM Major Facilitator DY470_11705 ENOG4105W8X HesB YadR YfhF-family protein DY470_11715 ENOG4105DXD 2-methylcitrate dehydratase DY470_11720 ENOG4105CR4 methylisocitrate lyase DY470_11725 ENOG4105C1G acyl-Coa dehydrogenase DY470_11730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY470_11740 ENOG4105N14 lysine exporter protein LysE YggA DY470_11745 ENOG4105E39 Enoyl-CoA hydratase DY470_11760 ENOG4107RFY SbcCD D subunit DY470_11780 ENOG4105FCD Major Facilitator DY470_11790 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DY470_11795 ENOG4105E4F Isochorismate synthase DY470_11800 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DY470_11805 ENOG4105WQI isochorismatase DY470_11810 ENOG4105CEY Amp-dependent synthetase and ligase DY470_11815 ENOG4105WQT MbtH domain protein DY470_11820 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_11835 ENOG4105K70 DNA-binding protein DY470_11855 ENOG4105BZG amino acid carrier protein DY470_11875 ENOG4105FE9 pseudouridine synthase DY470_11880 ENOG4105C22 threonyL-tRNA synthetase DY470_11885 ENOG4105C19 ABC transporter DY470_11895 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DY470_11935 ENOG4108D32 Methyltransferase DY470_11955 ENOG41081I9 integral membrane protein DY470_11965 ENOG4108Y4K DNA-binding transcriptional activator DY470_11980 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY470_11990 ENOG4105EYF MMPL domain protein DY470_12015 ENOG4105WCN acetyltransferase DY470_12025 ENOG41085FC arsR family transcriptional regulator DY470_12030 ENOG4105CAY ferredoxin--nadp reductase DY470_12045 ENOG4105CN5 Metallo-Beta-Lactamase DY470_12050 ENOG4107YZX Universal stress protein DY470_12055 ENOG4105CHH sulfate transporter DY470_12065 ENOG4105VUN Transcriptional regulator DY470_12075 ENOG41082YX Transcriptional regulator, arsr family DY470_12080 ENOG4105D6J arsenicaL-resistance protein DY470_12155 ENOG4105C1Q protoporphyrinogen oxidase DY470_12165 ENOG41068WN DY470_12175 ENOG4105VEQ Cold shock protein DY470_12200 ENOG4107V2S Transcriptional regulator DY470_12205 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY470_12220 ENOG4105DND Transcriptional regulator DY470_12225 ENOG4108RPX mosc domain containing protein DY470_12240 ENOG4105BZ1 (ABC) transporter DY470_12245 ENOG4105BZ1 (ABC) transporter DY470_12265 ENOG4108JCI Transcriptional regulator DY470_12295 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DY470_12310 ENOG4108KPJ rna polymerase sigma factor DY470_12330 ENOG4105F32 YngK protein DY470_12355 ENOG4105RD7 BadF BadG BcrA BcrD DY470_12365 ENOG4107STF Involved in phosphonate degradation (By similarity) DY470_12390 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY470_12405 ENOG4105C1J atp-dependent rna helicase DY470_12425 ENOG4108RZE Tetr family transcriptional regulator DY470_12455 ENOG4108I0C methyltransferase DY470_12490 ENOG4107RA9 decarboxylase DY470_12495 ENOG41090HR transcriptional regulator DY470_12525 ENOG4105CIN aminoacyl-histidine dipeptidase DY470_12535 ENOG4105EQK -acetyltransferase DY470_12550 ENOG4107RVG penicillin-binding protein DY470_12565 ENOG4107RF6 penicillin-binding protein DY470_12570 ENOG4107RF6 penicillin-binding protein DY470_12580 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DY470_12585 ENOG4105ETE Transcriptional regulator (LacI family DY470_12590 ENOG4105IE8 Alpha-ketoglutarate permease DY470_12600 ENOG4105CK5 oxidoreductase DY470_12630 ENOG4105DH8 myo-inositol catabolism DY470_12645 ENOG4105CGH 5'-nucleotidase DY470_12660 ENOG4105VZ8 Transcriptional regulator DY470_12680 ENOG4108VXD carboxy-peptidase DY470_12695 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity DY470_12700 ENOG41067SE Tetr family transcriptional regulator DY470_12770 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) DY470_12805 ENOG4105C1G acyl-Coa dehydrogenase DY470_12810 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DY470_12815 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DY470_12820 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DY470_12825 ENOG4105E39 Enoyl-CoA hydratase DY470_12830 ENOG4107QX3 carboxylase DY470_12835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY470_12850 ENOG4105DBI uridine monophosphokinase DY470_12860 ENOG4105DZ1 carboxypeptidase DY470_12875 ENOG4105T9C HD domain DY470_12885 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DY470_12920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DY470_12935 ENOG4105FQP Beta-lactamase DY470_12950 ENOG4107Y80 Major Facilitator superfamily DY470_13020 ENOG4105CPQ Dehydrogenase DY470_13040 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DY470_13050 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DY470_13060 ENOG4105DK7 lysyl-tRNA synthetase DY470_13145 ENOG4105ETU transcriptional activator (TenA DY470_13200 ENOG4105VTR Integrase DY470_13270 ENOG4105KNA -acetyltransferase DY470_13280 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein DY470_13315 ENOG410900G Protein of unknown function (DUF421) DY470_13355 ENOG4105CAR Terminase, large subunit DY470_13365 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY470_13445 ENOG4107TSN permease DY470_13535 ENOG410667J hydrolase DY470_13540 ENOG4105BZU Histidine kinase DY470_13545 ENOG4107RF6 penicillin-binding protein DY470_13580 ENOG4108HGU Histidine kinase DY470_13590 ENOG4105RHY Pfam:UPF0157 DY470_13600 ENOG4105CJN penicillin-binding protein DY470_13615 ENOG4105FQP Beta-lactamase DY470_13650 ENOG4108V4B ThiJ pfpI DY470_13680 ENOG4107Y80 Major Facilitator superfamily DY470_13695 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DY470_13745 ENOG4105FCD Major Facilitator DY470_13750 ENOG4105E09 nadh pyrophosphatase DY470_13755 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DY470_13790 ENOG4108XI2 Domain of unknown function (DUF1963) DY470_13810 ENOG4108NRW Phospholipase, patatin family DY470_13815 ENOG4105KWG Pfam:DUF1696 DY470_13850 ENOG4105PKS Excinuclease abc c subunit domain protein DY470_13885 ENOG4107VFR oxidoreductase DY470_13910 ENOG4105PAD Hydrolase DY470_13930 ENOG4108IUM Glycogen debranching enzyme DY470_13955 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DY470_13965 ENOG4105FDR Membrane DY470_13970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DY470_14020 ENOG4105MSI germination protein ypeb DY470_14050 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DY470_14055 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DY470_14060 ENOG4107Z3H Transcriptional regulator, TetR family DY470_14095 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DY470_14110 ENOG4105E98 transcriptional regulator DeoR family DY470_14135 ENOG4107QKR Dehydrogenase DY470_14145 ENOG4107RUY (E1 component), alpha subunit DY470_14155 ENOG4105E1F short-chain dehydrogenase reductase DY470_14160 ENOG4105RHY Pfam:UPF0157 DY470_14170 ENOG4108TIT dATP pyrophosphohydrolase DY470_14195 ENOG4107SQ8 Glycine betaine DY470_14200 ENOG4108IJ7 Glycine betaine DY470_14225 ENOG4105E66 phosphoriboisomerase A DY470_14230 ENOG41082BV acetyltransferase DY470_14235 ENOG4108M1A Chitin-binding protein DY470_14255 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY470_14275 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DY470_14305 ENOG4108Z7F N-acetyltransferase DY470_14325 ENOG4105EEM helicase DY470_14345 ENOG4105C9U ATP-dependent DNA helicase RecQ DY470_14390 ENOG4108M1A Chitin-binding protein DY470_14410 ENOG4105BZG amino acid carrier protein DY470_14415 ENOG4105C26 Dehydrogenase DY470_14425 ENOG4105CTU Proline racemase DY470_14430 ENOG4105CTU Proline racemase DY470_14435 ENOG41080HI glycine oxidase DY470_14445 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DY470_14490 ENOG4107T5V SNARE associated Golgi DY470_14505 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DY470_14525 ENOG4105DTQ mandelate racemase muconate lactonizing DY470_14575 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) DY470_14580 ENOG4105BZU Histidine kinase DY470_14585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_14620 ENOG4105DPN Oligoendopeptidase f DY470_14625 ENOG4105DVH amino acid DY470_14635 ENOG4105EPR degv family DY470_14680 ENOG4106K7D Major facilitator family transporter DY470_14700 ENOG4107BMA Transglycosylase associated protein DY470_14715 ENOG41089UC methyltransferase, type 11 DY470_14745 ENOG4105CHM Aminotransferase DY470_14760 ENOG4108ZMI UPF0477 protein DY470_14775 ENOG4105DVE abc transporter atp-binding protein DY470_14825 ENOG4105C02 permease DY470_14835 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DY470_14840 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DY470_14845 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DY470_14870 ENOG4105E09 nadh pyrophosphatase DY470_14890 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DY470_14950 ENOG4107VMI polysaccharide deacetylase DY470_14960 ENOG4108ZCF integral membrane protein DY470_14965 ENOG4105E0M Sulfatase DY470_14975 ENOG4105C5H ABC transporter DY470_14985 ENOG4105EYF MMPL domain protein DY470_14990 ENOG41082JN Transcriptional regulator DY470_15010 ENOG4105CIH Imidazole acetol-phosphate transaminase DY470_15020 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DY470_15060 ENOG41069ER domain protein DY470_15070 ENOG4105CY2 Citrate transporter DY470_15075 ENOG4105E39 Enoyl-CoA hydratase DY470_15080 ENOG4105J5T Amp-dependent synthetase and ligase DY470_15085 ENOG4108JUB Transcriptional regulator DY470_15105 ENOG4105D4B ABC, transporter DY470_15110 ENOG4105F5R ABC transporter DY470_15115 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DY470_15125 ENOG4105DKT Transcriptional regulator DY470_15130 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DY470_15140 ENOG41061GT Aldolase DY470_15160 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DY470_15195 ENOG4105II7 pyrroline-5-carboxylate reductase DY470_15205 ENOG4107258 Transcriptional regulator DY470_15220 ENOG4105E0Y RtcB Protein DY470_15225 ENOG4105ECK Fatty Acid Desaturase DY470_15230 ENOG4105G6Z alkaline phosphatase DY470_15240 ENOG4105VMP Transcriptional regulator DY470_15255 ENOG41090T1 Membrane DY470_15265 ENOG4108WCX response regulator DY470_15285 ENOG4105KNA -acetyltransferase DY470_15315 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY470_15340 ENOG4105CKK Glycosyl transferase, family 2 DY470_15360 ENOG4105CKK Glycosyl transferase, family 2 DY470_15370 ENOG4105C8Y Acetylornithine aminotransferase DY470_15430 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY470_15440 ENOG4108TVJ Nitroreductase DY470_15445 ENOG4105FS7 Transcriptional regulator DY470_15475 ENOG4105CMR udp-glucose 4-epimerase DY470_15480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DY470_15510 ENOG4108XET gCN5-related N-acetyltransferase DY470_15580 ENOG410635A Membrane DY470_15585 ENOG4105KNA -acetyltransferase DY470_15590 ENOG4108IQI permease DY470_15600 ENOG4105F1N DNA alkylation repair DY470_15630 ENOG4107RF6 penicillin-binding protein DY470_15665 ENOG4105P4J Allophanate hydrolase, subunit 1 DY470_15670 ENOG4107258 Transcriptional regulator DY470_15680 ENOG4106N3A copper homeostasis protein cutc DY470_15685 ENOG4108ZRV stage ii sporulation protein p DY470_15690 ENOG4108ZHR arsR family transcriptional regulator DY470_15700 ENOG4105FDT acyl-CoA dehydrogenase DY470_15715 ENOG4105DWD nucleoside recognition domain protein DY470_15740 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DY470_15800 ENOG4105E2A Dehydrogenase DY470_15810 ENOG4108IJ0 Aspartate ammonia-lyase DY470_15815 ENOG4105HDK L-asparaginase DY470_15820 ENOG4108IMY Transcriptional regulator DY470_15840 ENOG4108B31 Spore germination protein DY470_15850 ENOG4105BZU Histidine kinase DY470_15875 ENOG41075H3 AraC family transcriptional regulator DY470_15895 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DY470_15900 ENOG4105CUB amino acid DY470_15910 ENOG4105II7 pyrroline-5-carboxylate reductase DY470_15920 ENOG4105C6K Malic enzyme DY470_15930 ENOG4108NHD germination protein DY470_15935 ENOG4108Q8B Spore germination protein DY470_15955 ENOG4105CSV Glutaminase DY470_15990 ENOG4105CGH 5'-nucleotidase DY470_16010 ENOG4106A3M Cytochrome p-450 DY470_16035 ENOG4107UGY Proline imino-peptidase DY470_16045 ENOG4108QY0 Membrane DY470_16050 ENOG4105DSE periplasmic solute binding protein DY470_16060 ENOG41061CK Antibiotic biosynthesis monooxygenase DY470_16115 ENOG4105CVP deoxyribo-dipyrimidine photolyase DY470_16130 ENOG4108TWJ NADH dehydrogenase subunit 5 DY470_16135 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DY470_16150 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DY470_16160 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DY470_16165 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DY470_16170 ENOG4105DSE periplasmic solute binding protein DY470_16175 ENOG4105CC5 ABC transporter DY470_16180 ENOG4105DIK (ABC) transporter DY470_16195 ENOG4105Z7P Acetyltransferase (GNAT) family DY470_16205 ENOG4105D6J arsenicaL-resistance protein DY470_16210 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DY470_16215 ENOG41085FC arsR family transcriptional regulator DY470_16230 ENOG4105F7F Chaperone DY470_16240 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DY470_16245 ENOG4108YXU transcriptional regulator AsnC family DY470_16300 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DY470_16305 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_16315 ENOG4105IIP Membrane DY470_16330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_16335 ENOG41062D9 Histidine kinase DY470_16365 ENOG4105K6H D-cysteine desulfhydrase DY470_16400 ENOG4108NNI Beta-lactamase domain-containing protein DY470_16405 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase DY470_16415 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DY470_16445 ENOG4105W1Y Transcriptional regulator DY470_16450 ENOG4105JQZ Methyltransferase DY470_16470 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DY470_16485 ENOG4105BZU Histidine kinase DY470_16495 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DY470_16515 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DY470_16530 ENOG4108JQ1 Dehydrogenase DY470_16550 ENOG4108AEY RNA polymerase sigma factor DY470_16565 ENOG41082W1 Cupin 2, conserved barrel domain protein DY470_16575 ENOG410874W AraC family transcriptional regulator DY470_16595 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY470_16635 ENOG4108ISG Major Facilitator DY470_16645 ENOG4107MII Sugar-specific transcriptional regulator TrmB DY470_16650 ENOG4105CZM Major Facilitator DY470_16665 ENOG4105DA5 (ABC) transporter DY470_16670 ENOG41069JR DY470_16680 ENOG4105RXJ DY470_16685 ENOG4105KPY Small multidrug resistance protein DY470_16690 ENOG4105KBX Transcriptional regulator, TetR family DY470_16695 ENOG4107AUC DY470_16705 ENOG4105CRW Short chain fatty acid transporter DY470_16715 ENOG4105DYS nad(p)h dehydrogenase (quinone) DY470_16750 ENOG4105D7V transposase DY470_16755 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DY470_16780 ENOG4108K8S endonuclease I DY470_16785 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DY470_16800 ENOG4105EQ0 Major Facilitator superfamily DY470_16805 ENOG4108IND Tetr family transcriptional regulator DY470_16810 ENOG4107TXC Transcriptional regulator DY470_16830 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DY470_16835 ENOG4108Z66 YbaK ebsC protein DY470_16840 ENOG4105CUT histidyl-tRNA synthetase DY470_16855 ENOG4105KVH Transcriptional regulator DY470_16860 ENOG4108RCM Nitroreductase DY470_16880 ENOG4108PSK reductase DY470_16890 ENOG4105CJ1 ABC, transporter DY470_16945 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DY470_16950 ENOG4105DKQ ROK family DY470_16955 ENOG4106UW1 Major Facilitator superfamily DY470_16960 ENOG4108UW5 maltose o-acetyltransferase DY470_16965 ENOG4105C31 Tryptophanyl-tRNA synthetase DY470_16990 ENOG4105DMQ Methyltransferase DY470_17000 ENOG4105EV4 Multidrug resistance protein mdtH DY470_17030 ENOG4105C37 (CBS) domain DY470_17045 ENOG4105DDN Pentapeptide repeat-containing protein DY470_17050 ENOG4105XDF Protein of unknown function (DUF1272) DY470_17060 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DY470_17065 ENOG4105CMG Carbohydrate kinase DY470_17070 ENOG4105C6Z Gluconate DY470_17075 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DY470_17090 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DY470_17125 ENOG4105C44 Serine transporter DY470_17155 ENOG4108TZY GntR Family Transcriptional Regulator DY470_17160 ENOG4105D9R oxidoreductase DY470_17165 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DY470_17170 ENOG4105KVH Transcriptional regulator DY470_17175 ENOG4105KVH Transcriptional regulator DY470_17215 ENOG4105JAB phenazine biosynthesis protein, phzf family DY470_17225 ENOG4105CHR reductase DY470_17240 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DY470_17245 ENOG4105KVH Transcriptional regulator DY470_17270 ENOG4108TYN CAAX amino terminal protease family protein DY470_17345 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DY470_17360 ENOG4107YXZ hydrolase, family 25 DY470_17440 ENOG4105K7K Transcriptional regulator DY470_17445 ENOG4105CIS alcohol dehydrogenase DY470_17480 ENOG4108TN2 lmbE family DY470_17490 ENOG4107R3E Citrate transporter DY470_17505 ENOG4105NX3 Membrane DY470_17510 ENOG4107ZY0 Phenazine biosynthesis-like protein DY470_17530 ENOG4107V2S Transcriptional regulator DY470_17550 ENOG4105C98 muts2 protein DY470_17560 ENOG4105E5K Alpha-amylase DY470_17565 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DY470_17570 ENOG4105DPN Oligoendopeptidase f DY470_17575 ENOG4108A04 Beta-lactamase DY470_17605 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DY470_17630 ENOG41082BM Transcriptional regulator, arsr family DY470_17635 ENOG4105CIS alcohol dehydrogenase DY470_17655 ENOG4105C09 Bile acid DY470_17660 ENOG4105CQB FAD linked oxidase domain protein DY470_17685 ENOG4108UT6 Transferase hexapeptide repeat containing protein DY470_17695 ENOG4105K64 Glycosyl transferase, family 2 DY470_17700 ENOG4105E39 Enoyl-CoA hydratase DY470_17710 ENOG4105KT7 mgtC SapB transporter DY470_17725 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DY470_17730 ENOG41073R8 VanW family DY470_17740 ENOG4108R1P DY470_17755 ENOG4105VEQ Cold shock protein DY470_17775 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DY470_17795 ENOG410904N short-chain dehydrogenase reductase DY470_17805 ENOG4106IQC argininosuccinate lyase DY470_17820 ENOG4108IA2 Sodium pantothenate symporter DY470_17830 ENOG4105C26 Dehydrogenase DY470_17835 ENOG4105CHR reductase DY470_17845 ENOG4105EWU Squalene--hopene cyclase DY470_17855 ENOG4105FR1 rard protein DY470_17860 ENOG410696E Membrane DY470_17875 ENOG4105D1F ATP-binding protein DY470_17885 ENOG4108ZAF Molybdopterin DY470_17890 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY470_17895 ENOG4105D06 uba thif-type nad fad binding protein DY470_17900 ENOG4105TMB Formate nitrite transporter DY470_17910 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DY470_17915 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DY470_17925 ENOG4108JB9 formate dehydrogenase DY470_17930 ENOG4105E1K spore germination protein DY470_17995 ENOG4107QJT sodium dicarboxylate symporter DY470_18000 ENOG4108KGH TRANSCRIPTIONal DY470_18010 ENOG4105EMN RNA polymerase sigma factor DY470_18035 ENOG4105CIG ABC transporter DY470_18045 ENOG4105D9R oxidoreductase DY470_18055 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DY470_18060 ENOG4105K4P CoA-binding domain protein DY470_18065 ENOG4105C0H protease DY470_18070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_18080 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DY470_18085 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DY470_18090 ENOG4105W8X HesB YadR YfhF-family protein DY470_18120 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DY470_18125 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DY470_18135 ENOG4105BZ1 (ABC) transporter DY470_18140 ENOG4108I0Z Aconitate hydratase DY470_18180 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DY470_18200 ENOG4107F3J Amp-dependent synthetase and ligase DY470_18205 ENOG4107ZYJ bioY protein DY470_18210 ENOG4105CEY Amp-dependent synthetase and ligase DY470_18225 ENOG4108IMY Transcriptional regulator DY470_18275 ENOG4107AYK membrAne DY470_18290 ENOG4105BZU Histidine kinase DY470_18295 ENOG4105FBA Phospholipase Carboxylesterase DY470_18300 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DY470_18305 ENOG4105CK7 Sodium proline symporter DY470_18310 ENOG4105CBC glutamate synthase DY470_18315 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DY470_18320 ENOG4108VJ1 Transcriptional regulator (CarD family DY470_18325 ENOG4108903 Formimidoylglutamase DY470_18350 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DY470_18395 ENOG4107QIV Cytochrome c biogenesis protein DY470_18410 ENOG4105CH2 amidohydrolase DY470_18420 ENOG4105CJ1 ABC, transporter DY470_18430 ENOG4107RSM transcriptional regulator DY470_18440 ENOG41067MG lrgb family DY470_18465 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DY470_18485 ENOG4105BZ1 (ABC) transporter DY470_18490 ENOG4105BZ1 (ABC) transporter DY470_18535 ENOG4105CGH 5'-nucleotidase DY470_18545 ENOG4108SVB resolvase DY470_18565 ENOG4105K7K Transcriptional regulator DY470_18570 ENOG4105C5F glutamine synthetase DY470_18575 ENOG4105KV4 Transcriptional regulator DY470_18580 ENOG4105CXI aluminum resistance protein DY470_18585 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DY470_18590 ENOG4105EN6 Membrane DY470_18595 ENOG4106F1P AAA ATPase, central domain protein DY470_18625 ENOG41069ER domain protein DY470_18630 ENOG4105DM4 PTS System DY470_18635 ENOG4105DE4 1-phosphofructokinase DY470_18640 ENOG4105E98 transcriptional regulator DeoR family DY470_18645 ENOG4107QW4 alcohol dehydrogenase DY470_18650 ENOG4108SJC Membrane DY470_18680 ENOG4105TMB Formate nitrite transporter DY470_18685 ENOG4105K70 DNA-binding protein DY470_18695 ENOG4105C59 p-type ATPase DY470_18700 ENOG410681U heavy metal transport detoxification protein DY470_18705 ENOG4105VPX protein, conserved in bacteria DY470_18715 ENOG4105NIV Esterase DY470_18720 ENOG4105E0A ABC, transporter DY470_18740 ENOG4105CGK Exodeoxyribonuclease III DY470_18750 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DY470_18755 ENOG4105D03 DNA-3-methyladenine glycosylase II DY470_18785 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DY470_18790 ENOG4105BZU Histidine kinase DY470_18810 ENOG41067MG lrgb family DY470_18825 ENOG4107TTQ Alpha beta hydrolase fold DY470_18865 ENOG4105F0V Cell wall hydrolase DY470_18880 ENOG4105E0M Sulfatase DY470_18885 ENOG410890F Dynamin family DY470_18895 ENOG4107QHE Choloylglycine hydrolase DY470_18920 ENOG4105DA5 (ABC) transporter DY470_18950 ENOG4105DQU oxidoreductase, subunit beta DY470_18955 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DY470_18960 ENOG4108IGT Dipeptidase DY470_18965 ENOG4105MCT stage V sporulation protein S DY470_18970 ENOG4105D48 metallophosphoesterase DY470_18995 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DY470_19010 ENOG4105XZV Protein of unknown function (DUF3243) DY470_19015 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DY470_19035 ENOG4105UIB (ABC) transporter DY470_19040 ENOG4108JQ9 ABC transporter DY470_19045 ENOG4105DIH basic membrane DY470_19050 ENOG4105FDP GntR family transcriptional regulator DY470_19055 ENOG4107QZI cell division protein FtsK DY470_19065 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DY470_19080 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DY470_19090 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DY470_19095 ENOG4108S0H Dipicolinic acid synthetase, b subunit DY470_19100 ENOG4105E35 Dipicolinate synthase subunit A DY470_19110 ENOG4105C1V Peptidase, M16 DY470_19130 ENOG4105DTN riboflavin biosynthesis protein ribF DY470_19145 ENOG4105W7A Protein of unknown function (DUF503) DY470_19155 ENOG4105VHM ribosomal protein DY470_19160 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DY470_19165 ENOG4105CHV Transcription elongation factor NusA DY470_19175 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DY470_19185 ENOG4105DZP Membrane-associated zinc metalloprotease DY470_19190 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DY470_19195 ENOG4105KNE Phosphatidate cytidylyltransferase DY470_19240 ENOG4108HE4 integrase family DY470_19250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DY470_19255 ENOG4105C79 DNA protecting protein DprA DY470_19260 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DY470_19275 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DY470_19300 ENOG4105VB6 UPF0109 protein DY470_19320 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DY470_19325 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DY470_19340 ENOG4105CHR reductase DY470_19345 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DY470_19360 ENOG4105CB5 ATP-dependent DNA helicase recG DY470_19365 ENOG4105DP4 dak2 domain fusion protein ylov DY470_19370 ENOG4108ZAA Alkaline-shock protein DY470_19385 ENOG4105FJ0 thiamine DY470_19390 ENOG4105DJV ribulose-phosphate 3-epimerase DY470_19400 ENOG4105D9P serine threonine protein kinase DY470_19405 ENOG4108ZF3 Phosphatase DY470_19415 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DY470_19425 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY470_19430 ENOG4105C25 Primosomal protein n' DY470_19435 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DY470_19455 ENOG4105DSJ YicC domain protein DY470_19465 ENOG4105F23 Fibronectin-binding protein DY470_19470 ENOG4105DC7 peptidase M24 DY470_19525 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DY470_19550 ENOG4105C34 Pseudouridine synthase DY470_19575 ENOG4105DBK s4 domain protein DY470_19580 ENOG41067XK integral membrane protein DY470_19590 ENOG4105DFA alanine racemase domain protein DY470_19595 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DY470_19600 ENOG4105WR5 sporulation protein, YlmC YmxH family DY470_19610 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_19620 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DY470_19625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DY470_19630 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DY470_19635 ENOG4105D4A Cell wall formation (By similarity) DY470_19640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DY470_19645 ENOG4105CNI cell division protein FtsW DY470_19660 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DY470_19665 ENOG4105CJN penicillin-binding protein DY470_19670 ENOG4105CJN penicillin-binding protein DY470_19675 ENOG41068DC Essential cell division protein (By similarity) DY470_19710 ENOG4105KNH Nucleic acid-binding protein DY470_19720 ENOG41063PX domain protein DY470_19725 ENOG4105D78 K07001 NTE family protein DY470_19730 ENOG4105H20 Sporulation integral membrane protein YlbJ DY470_19740 ENOG4106H78 methyltransferase DY470_19760 ENOG4107TB6 phosphoglycerate mutase DY470_19775 ENOG4106UY4 Inherit from COG: Scp-like extracellular DY470_19825 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DY470_19835 ENOG4105CNI cell division protein FtsW DY470_19850 ENOG4108IAB Phoh family DY470_19870 ENOG4105QA2 DY470_19875 ENOG4105CI3 gtp-binding protein typa DY470_19885 ENOG4105ECY inositol monophosphatase DY470_19905 ENOG4105CXN decarboxylase DY470_19955 ENOG4105CPP Dehydrogenase, E1 component DY470_19970 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DY470_19975 ENOG4108X4Q Hydrolase DY470_19990 ENOG4105CN5 Metallo-Beta-Lactamase DY470_19995 ENOG4107ZYR domain protein DY470_20030 ENOG4108XRC Protein of unknown function (DUF458) DY470_20035 ENOG4107IN1 Protein of unknown function (DUF1797) DY470_20050 ENOG4105EPM Diguanylate phosphodiesterase DY470_20055 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DY470_20075 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DY470_20085 ENOG4105UIN DY470_20145 ENOG4108HGU Histidine kinase DY470_20155 ENOG4105CHM Aminotransferase DY470_20160 ENOG4105FKQ transcriptional regulator DY470_20165 ENOG4105EG2 ABC transporter, permease DY470_20175 ENOG4107FKK extracellular solute-binding protein family 1 DY470_20185 ENOG4105CG3 alpha amylase, catalytic region DY470_20235 ENOG4105CHU acetyl-coa acetyltransferase DY470_20270 ENOG4105K7K Transcriptional regulator DY470_20275 ENOG4105DTD Dehydrogenase DY470_20295 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DY470_20335 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DY470_20360 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DY470_20375 ENOG4105CID antiterminator DY470_20385 ENOG4105FDP GntR family transcriptional regulator DY470_20395 ENOG4105CE4 GlcNAc 6-P deacetylase DY470_20440 ENOG4107ZE5 PPIases accelerate the folding of proteins DY470_20445 ENOG4105PTM secreted protein DY470_20450 ENOG4105J7I hydrolase DY470_20460 ENOG4105G6R Stage v sporulation protein ae DY470_20470 ENOG4105CZ3 stage V sporulation protein ad DY470_20475 ENOG41090VF Stage v sporulation protein ac DY470_20495 ENOG4105C8J )-transporter DY470_20500 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_20510 ENOG41082AN stage II sporulation protein DY470_20515 ENOG4105DZ1 carboxypeptidase DY470_20525 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DY470_20530 ENOG4105DVE abc transporter atp-binding protein DY470_20565 ENOG4105D7N magnesium and cobalt transport protein CorA DY470_20590 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DY470_20600 ENOG4105I3K Ferric uptake regulator, Fur family DY470_20605 ENOG4105MZ9 stage II sporulation protein m DY470_20625 ENOG4105CPC Aldo Keto reductase DY470_20635 ENOG4105RHY Pfam:UPF0157 DY470_20655 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DY470_20665 ENOG4105ETE Transcriptional regulator (LacI family DY470_20670 ENOG4108YM7 Gcn5-related n-acetyltransferase DY470_20690 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DY470_20695 ENOG4108R6K riboflavin synthase, subunit alpha DY470_20715 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DY470_20720 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY470_20725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DY470_20730 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DY470_20740 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DY470_20750 ENOG4105DFD Na H antiporter DY470_20755 ENOG4105CGH 5'-nucleotidase DY470_20810 ENOG4108IXY short-chain dehydrogenase reductase DY470_20815 ENOG41069FQ Metallo-beta-lactamase superfamily DY470_20820 ENOG4105II7 pyrroline-5-carboxylate reductase DY470_20825 ENOG4105EJQ L-serine dehydratase DY470_20855 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DY470_20865 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DY470_20870 ENOG4105D9U N-acetyltransferase DY470_20880 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DY470_20885 ENOG4108QEG Membrane DY470_20890 ENOG4105CDA abc transporter atp-binding protein DY470_20895 ENOG4105E5Q amino acid AbC transporter DY470_20900 ENOG4108HW3 (ABC) transporter DY470_20915 ENOG4105G7B Protein of unknown function (DUF2992) DY470_20920 ENOG4105E09 nadh pyrophosphatase DY470_20930 ENOG4105C7S Dehydrogenase DY470_20935 ENOG4105CPP Dehydrogenase, E1 component DY470_20955 ENOG4107RDP Dehydrogenase DY470_20970 ENOG4108JUB Transcriptional regulator DY470_20980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DY470_20995 ENOG4107QQR Sporulation DY470_21005 ENOG4105S1Z Stage IV sporulation protein B DY470_21010 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DY470_21020 ENOG4105DX0 Hemolysin A DY470_21030 ENOG4105CTB Polyprenyl synthetase DY470_21055 ENOG4108ZSR alkaline shock protein DY470_21060 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DY470_21085 ENOG410644B Stage III sporulation protein af DY470_21095 ENOG4105KQ4 Stage iii sporulation protein ad DY470_21100 ENOG4108CQH stage III sporulation protein AC DY470_21105 ENOG4105KR5 Stage iii sporulation protein DY470_21110 ENOG4105CD2 stage iii sporulation protein aa DY470_21135 ENOG4105DC7 peptidase M24 DY470_21150 ENOG4105CBJ Metal-dependent enzyme DY470_21160 ENOG4107YBY Hydrolase DY470_21195 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DY470_21200 ENOG4105WZW rhodanese family DY470_21220 ENOG41080TC multidrug resistance protein DY470_21255 ENOG4105CJ1 ABC, transporter DY470_21260 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DY470_21295 ENOG4105C0D helicase DY470_21410 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DY470_21415 ENOG4105C3R Methionine synthase DY470_21425 ENOG4105C28 cystathionine DY470_21430 ENOG4105C28 cystathionine DY470_21450 ENOG4105C5X domain protein DY470_21460 ENOG4105DKQ ROK family DY470_21470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DY470_21485 ENOG4108UTW Plays a role in the regulation of phosphate uptake DY470_21490 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DY470_21495 ENOG4105E2Z phosphate ABC transporter (Permease DY470_21500 ENOG4105C8U phosphate abc transporter DY470_21505 ENOG4105PWN phosphate abc transporter DY470_21510 ENOG4107RF6 penicillin-binding protein DY470_21520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY470_21545 ENOG4105N80 Ferric uptake regulator, Fur family DY470_21555 ENOG4105FDK ABC transporter DY470_21560 ENOG4108JYZ YitT family DY470_21565 ENOG41069ZM Protein of unknown function (DUF2624) DY470_21590 ENOG4105EGD dinuclear metal center protein, YbgI family DY470_21605 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_21610 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DY470_21635 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DY470_21640 ENOG4105KG3 cytidine deaminase DY470_21645 ENOG4107YR5 Diacylglycerol kinase DY470_21655 ENOG4105CTJ Metal Dependent Phosphohydrolase DY470_21660 ENOG4105C9A Phoh family DY470_21670 ENOG41068P3 sporulation protein YqfC DY470_21675 ENOG4105KTH gatB Yqey DY470_21690 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DY470_21695 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DY470_21715 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DY470_21725 ENOG4105CSA Coproporphyrinogen iii oxidase DY470_21730 ENOG4105KVH Transcriptional regulator DY470_21755 ENOG4105TQK DNA polymerase iii, delta' subunit DY470_21765 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DY470_21770 ENOG4108UK2 deaminase DY470_21775 ENOG4105KQC Competence protein DY470_21785 ENOG4105DXX methyltransferase DY470_21795 ENOG4108WF2 Metal Dependent Phosphohydrolase DY470_21805 ENOG410812S Rna-binding protein DY470_21815 ENOG4105CQW ribosome biogenesis GTPase YqeH DY470_21820 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DY470_21835 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_21855 ENOG4108TVJ Nitroreductase DY470_21870 ENOG4105G6Z alkaline phosphatase DY470_21880 ENOG4108MUZ hydrolase DY470_21915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DY470_21920 ENOG4105MIR Phenylalanine 4-monooxygenase DY470_21930 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DY470_21970 ENOG4105S6R Iron-hydroxamate transporter permease subunit DY470_21975 ENOG4108V5C ABC transporter DY470_21990 ENOG4108EKI Dehydrogenase DY470_21995 ENOG4105C28 cystathionine DY470_22025 ENOG4107XRG penicillin-binding protein DY470_22040 ENOG4105CFP Peptidase U32 DY470_22045 ENOG4105XYU peptidase (U32 family) DY470_22050 ENOG4108VQJ O-methyltransferase DY470_22055 ENOG4105HHA aminodeoxychorismate lyase DY470_22085 ENOG4105C02 permease DY470_22100 ENOG41060CR DY470_22105 ENOG4105C7H Helicase, RecD TraA family DY470_22120 ENOG4105C3J Cysteine desulfurase DY470_22130 ENOG4105D1H recombination factor protein RarA DY470_22135 ENOG4108VCI transcription factor, rsfa family DY470_22145 ENOG4105CUZ uba thif-type nad fad binding protein DY470_22155 ENOG4105CUT histidyl-tRNA synthetase DY470_22165 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DY470_22175 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DY470_22180 ENOG41076HS cation diffusion facilitator family transporter DY470_22185 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DY470_22195 ENOG4105CKP Polysaccharide Biosynthesis Protein DY470_22200 ENOG4108QG2 Membrane DY470_22210 ENOG4105VIE preprotein translocase, subunit YajC DY470_22225 ENOG41061AI Protein of unknown function (DUF2905) DY470_22240 ENOG4108HUF Transporter DY470_22250 ENOG4108IPJ Membrane DY470_22255 ENOG41082BM Transcriptional regulator, arsr family DY470_22280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DY470_22285 ENOG4108IYU L-aspartate oxidase DY470_22300 ENOG4108RPX mosc domain containing protein DY470_22305 ENOG4105CQC Prephenate dehydratase DY470_22325 ENOG4105EWM Histidine kinase DY470_22350 ENOG4105X36 (ribosomal) protein DY470_22360 ENOG4105C03 ribonuclease DY470_22375 ENOG4107QMS site-determining protein DY470_22390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DY470_22395 ENOG4105DFF Rod shape-determining protein mreb DY470_22420 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DY470_22425 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DY470_22435 ENOG41068KH stage VI sporulation protein D DY470_22445 ENOG4105D52 delta-aminolevulinic acid dehydratase DY470_22470 ENOG4105K56 Transcriptional regulator DY470_22490 ENOG4108IUQ atp-dependent protease DY470_22520 ENOG4108QCI YvbH-like oligomerisation region DY470_22535 ENOG4105M59 Phosphodiesterase, mj0936 family DY470_22540 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DY470_22550 ENOG4108XJQ germination protein DY470_22560 ENOG4108PCX Major Facilitator DY470_22570 ENOG4105KBX Transcriptional regulator, TetR family DY470_22585 ENOG4105PFC Transcriptional regulator DY470_22595 ENOG4105DZC cytosine deaminase DY470_22600 ENOG41067S9 phage shock protein C, PspC DY470_22605 ENOG4108JCI Transcriptional regulator DY470_22615 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DY470_22620 ENOG4108Z40 Transcriptional regulator DY470_22625 ENOG4105RHA ABC transporter, permease DY470_22630 ENOG4108IUX (ABC) transporter DY470_22635 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DY470_22640 ENOG4105ER2 Ompa motb domain protein DY470_22645 ENOG4105E14 MotA TolQ exbB proton channel DY470_22650 ENOG4108VXD carboxy-peptidase DY470_22660 ENOG4105E33 succinate dehydrogenase DY470_22670 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DY470_22685 ENOG4105K63 Thioredoxin DY470_22690 ENOG4105C10 Electron transfer flavoprotein DY470_22695 ENOG4105BZJ Electron transfer flavoprotein DY470_22700 ENOG41060WC Enoyl-CoA hydratase DY470_22705 ENOG4107Z3H Transcriptional regulator, TetR family DY470_22710 ENOG4105CEY Amp-dependent synthetase and ligase DY470_22720 ENOG4105J76 Periplasmic binding protein DY470_22725 ENOG4105S6R Iron-hydroxamate transporter permease subunit DY470_22760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY470_22770 ENOG4105DR4 Methyltransferase DY470_22785 ENOG4105KFN sortase, SrtB family DY470_22790 ENOG4105E0A ABC, transporter DY470_22805 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DY470_22810 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DY470_22820 ENOG4105FE9 pseudouridine synthase DY470_22830 ENOG4105DCG PHP domain protein DY470_22865 ENOG4105C5S asparaginyl-tRNA synthetase DY470_22870 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DY470_22880 ENOG4108RWN rrna methyltransferase DY470_22915 ENOG4105C0R drug resistance transporter emrb qaca subfamily DY470_22920 ENOG4105CW7 secretion protein, HlyD family DY470_22925 ENOG4108JGH Tetr family transcriptional regulator DY470_22930 ENOG4105CN9 Peptidase m42 family protein DY470_22950 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DY470_22955 ENOG4105C22 threonyL-tRNA synthetase DY470_22960 ENOG4108TDW sporulation protein YtxC DY470_22980 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DY470_22985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DY470_22990 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DY470_23000 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DY470_23005 ENOG4105C2M dna polymerase I DY470_23010 ENOG4105BZU Histidine kinase DY470_23015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DY470_23030 ENOG4108HMX isocitrate dehydrogenase (NADP) DY470_23035 ENOG4105BZN citrate synthase DY470_23050 ENOG4108REF Sporulation integral membrane protein ytvi DY470_23055 ENOG4105FS0 cytoplasmic membrane protein DY470_23080 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DY470_23085 ENOG4105C6K Malic enzyme DY470_23090 ENOG4105C0B DNA polymerase III (alpha subunit) DY470_23095 ENOG4105VV2 DY470_23105 ENOG4105SFS phosphoesterase RecJ domain protein DY470_23135 ENOG4105DC7 peptidase M24 DY470_23170 ENOG4105Z7P Acetyltransferase (GNAT) family DY470_23175 ENOG41082W1 Cupin 2, conserved barrel domain protein DY470_23195 ENOG4107YZX Universal stress protein DY470_23240 ENOG4108JYZ YitT family DY470_23255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DY470_23265 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DY470_23270 ENOG4105KBJ sporulation protein ytfj DY470_23285 ENOG4105EFZ amidohydrolase DY470_23295 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DY470_23320 ENOG4106KR7 LysR family Transcriptional regulator DY470_23330 ENOG4105U5Y Transcriptional regulator DY470_23340 ENOG4105C28 cystathionine DY470_23355 ENOG4108IBT Inherit from COG: transposase DY470_23380 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DY470_23390 ENOG4105EMN RNA polymerase sigma factor DY470_23410 ENOG4105F1V Acetoin utilization protein DY470_23415 ENOG4105W87 Cbs domain DY470_23420 ENOG4105DGU Histone deacetylase DY470_23440 ENOG4105BZU Histidine kinase DY470_23445 ENOG4107SNB ankyrin repeat protein YahD DY470_23450 ENOG4105EP9 oxidoreductase DY470_23480 ENOG4105ETE Transcriptional regulator (LacI family DY470_23510 ENOG4105C88 aminopeptidase DY470_23555 ENOG4108VDD TRNA binding domain protein DY470_23585 ENOG4105C8F Beta-lactamase domain protein DY470_23600 ENOG4108V15 phosphotransferase enzyme family DY470_23605 ENOG4108IUM Glycogen debranching enzyme DY470_23615 ENOG4107QSE Dipeptidase DY470_23620 ENOG4105YW5 deoR family transcriptional regulator DY470_23635 ENOG4105CBX hi0933 family DY470_23660 ENOG4105D7V transposase DY470_23690 ENOG4108VJ1 Transcriptional regulator (CarD family DY470_23695 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DY470_23715 ENOG4108ZAF Molybdopterin DY470_23720 ENOG4105D7V transposase DY470_23730 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DY470_23735 ENOG4105CVM Molybdenum cofactor synthesis domain protein DY470_23745 ENOG4105D06 uba thif-type nad fad binding protein DY470_23750 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DY470_23770 ENOG41085GJ domain protein DY470_23780 ENOG4105DWV Homoserine O-trans-acetylase DY470_23790 ENOG4108B31 Spore germination protein DY470_23815 ENOG4105C8T Leucyl-tRNA synthetase DY470_23820 ENOG410605W Major Facilitator DY470_23830 ENOG4105NCW Trka-c domain protein DY470_23850 ENOG4105C19 ABC transporter DY470_23870 ENOG4105N5T Radical SAM Protein DY470_23880 ENOG4105CIG ABC transporter DY470_23915 ENOG4105E8V Alpha Beta Hydrolase Fold protein DY470_23920 ENOG4108Z0R Transferase DY470_23925 ENOG4105YVM Phosphoesterase, PA-phosphatase related DY470_23930 ENOG4105BZF Glycosyl transferase (Group 1 DY470_23940 ENOG4108RIR Molybdenum cofactor biosynthesis protein DY470_23995 ENOG4105EGD dinuclear metal center protein, YbgI family DY470_24000 ENOG4107XGZ Hydrolase DY470_24005 ENOG4105E98 transcriptional regulator DeoR family DY470_24020 ENOG4105BZU Histidine kinase DY470_24025 ENOG4105BZU Histidine kinase DY470_24030 ENOG4107S9D Alpha beta hydrolase DY470_24035 ENOG4107T7U Sulfatase DY470_24050 ENOG4105D2X ABC transporter substrate-binding protein DY470_24060 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DY470_24075 ENOG4107XGZ Hydrolase DY470_24125 ENOG4108V2W Carbonate dehydratase DY470_24130 ENOG4105C4M (Ubiquinol oxidase) subunit I DY470_24135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DY470_24180 ENOG41087YS Phage shock protein A DY470_24220 ENOG4105BZU Histidine kinase DY470_24225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_24250 ENOG4108UGV hypoxanthine phosphoribosyltransferase DY470_24255 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DY470_24275 ENOG4105C19 ABC transporter DY470_24290 ENOG4107ZTW SNARE associated Golgi DY470_24305 ENOG4105C19 ABC transporter DY470_24310 ENOG41086D8 Transcriptional regulator DY470_24320 ENOG41082BM Transcriptional regulator, arsr family DY470_24370 ENOG4105C6Z Gluconate DY470_24375 ENOG4105FDP GntR family transcriptional regulator DY470_24395 ENOG41069H0 dihydroorotase EC 3.5.2.3 DY470_24430 ENOG4105DTQ mandelate racemase muconate lactonizing DY470_24440 ENOG4108IPT Naphthoate synthase DY470_24445 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DY470_24455 ENOG4105E4F Isochorismate synthase DY470_24460 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DY470_24470 ENOG4105VEQ Cold shock protein DY470_24505 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DY470_24520 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DY470_24635 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DY470_24670 ENOG4105KT7 mgtC SapB transporter DY470_24675 ENOG4107PBV potassium channel DY470_24695 ENOG4105WG9 Conserved Protein DY470_24705 ENOG4105CHM Aminotransferase DY470_24710 ENOG4108ZB6 transcriptional regulator AsnC family DY470_24715 ENOG4105C5I Dehydrogenase DY470_24720 ENOG4108MUZ hydrolase DY470_24730 ENOG4105C87 Aminotransferase class I and II DY470_24740 ENOG4105Y38 Kinase-associated protein B DY470_24750 ENOG4107R3E Citrate transporter DY470_24770 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DY470_24775 ENOG4105KA0 thioesterase Superfamily protein DY470_24790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DY470_24810 ENOG41069ER domain protein DY470_24830 ENOG4105CEP NADH dehydrogenase DY470_24860 ENOG4105EWC Purine nucleoside phosphorylase DY470_24880 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DY470_24905 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DY470_24910 ENOG4105C4B ABC transporter, permease DY470_24920 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DY470_24945 ENOG41083MR nifu domain-containing protein DY470_24965 ENOG4108W5N phosphatidylglycerophosphatase a DY470_25005 ENOG4105C19 ABC transporter DY470_25025 ENOG4105BZ1 (ABC) transporter DY470_25045 ENOG4105DYS nad(p)h dehydrogenase (quinone) DY470_25055 ENOG4105D4U had-superfamily hydrolase, subfamily iia DY470_25070 ENOG4105CBT Fructose-1,6-bisphosphatase DY470_25090 ENOG4105MMD transcriptional regulator DY470_25095 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DY470_25100 ENOG4107TXC Transcriptional regulator DY470_25105 ENOG41090T1 Membrane DY470_25140 ENOG4105KZD Domain of unknown function (DUF1805) DY470_25145 ENOG4107R8B 5'-nucleotidase DY470_25175 ENOG4105DIW FeS assembly protein SUFB DY470_25180 ENOG4108UNV SUF system FeS assembly protein, NifU family DY470_25185 ENOG4105C9B Cysteine desulfurase DY470_25190 ENOG4105JRK feS assembly protein SufD DY470_25195 ENOG4105C3K feS assembly ATPase SufC DY470_25200 ENOG4105D01 (LipO)protein DY470_25205 ENOG4105D01 (LipO)protein DY470_25210 ENOG4108UMI ABC transporter, permease DY470_25240 ENOG41080E8 Transcriptional regulator, Spx MgsR family DY470_25320 ENOG4108W8B Beta-lactamase domain protein DY470_25325 ENOG4105C1G acyl-Coa dehydrogenase DY470_25330 ENOG4105CHU acetyl-coa acetyltransferase DY470_25345 ENOG4105DZ1 carboxypeptidase DY470_25365 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY470_25380 ENOG4108SUT Major Facilitator Superfamily DY470_25385 ENOG4107R7I amino acid DY470_25410 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DY470_25420 ENOG4107AYK membrAne DY470_25460 ENOG4107ZTW SNARE associated Golgi DY470_25470 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DY470_25475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_25480 ENOG4105BZU Histidine kinase DY470_25500 ENOG4105C8Q Methyl-accepting chemotaxis DY470_25505 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DY470_25510 ENOG4105VG1 fes assembly suf system protein DY470_25515 ENOG4105D4Y metalloprotease DY470_25535 ENOG4107S91 Sodium hydrogen exchanger DY470_25540 ENOG4105NCW Trka-c domain protein DY470_25550 ENOG4108RMU ferritin dps family protein DY470_25565 ENOG4108URH decarboxylase DY470_25585 ENOG4105D9N nucleoside DY470_25590 ENOG4105D9N nucleoside DY470_25600 ENOG4108RYK Nad-dependent epimerase dehydratase DY470_25615 ENOG4105CV8 reductase DY470_25620 ENOG4105F27 Major Facilitator DY470_25625 ENOG4105KVH Transcriptional regulator DY470_25640 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DY470_25670 ENOG4105C8Q Methyl-accepting chemotaxis DY470_25705 ENOG4105C5H ABC transporter DY470_25710 ENOG4108MK9 spermidine N(1)-acetyltransferase DY470_25730 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DY470_25740 ENOG4108IPW abc transporter atp-binding protein DY470_25745 ENOG4105CM4 permease protein DY470_25805 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DY470_25815 ENOG4105XZU Preprotein translocase, subunit SecG DY470_25820 ENOG41067MG lrgb family DY470_25840 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DY470_25870 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_25915 ENOG41090VF Stage v sporulation protein ac DY470_25920 ENOG4105CZ3 stage V sporulation protein ad DY470_25935 ENOG4105H67 Protein of unknown function (DUF421) DY470_25940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DY470_25950 ENOG4105KRI phosphocarrier protein (HPr DY470_25960 ENOG4105CHW UPF0052 protein DY470_25970 ENOG4108Z4K mutator MutT protein DY470_25980 ENOG4105C3M thioredoxin reductase DY470_25990 ENOG4108S4C acetyltransferase DY470_26010 ENOG41086DT Membrane protein of unknown function DY470_26020 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DY470_26040 ENOG4107TXC Transcriptional regulator DY470_26065 ENOG4105HMI Membrane DY470_26070 ENOG4105DUM transcriptional regulator, lysR family DY470_26080 ENOG4108WS4 fmn reductase DY470_26085 ENOG4105C5H ABC transporter DY470_26095 ENOG4105BZ1 (ABC) transporter DY470_26105 ENOG4105CN1 protease DY470_26110 ENOG4105CRP Part of the ABC transporter FtsEX involved in DY470_26115 ENOG4105CAK Cell division ATP-binding protein ftsE DY470_26135 ENOG4105MS2 ribosomal subunit Interface protein DY470_26140 ENOG4105VEQ Cold shock protein DY470_26145 ENOG41081UC Inherit from COG: Competence protein DY470_26155 ENOG4105K4H Nlp p60 protein DY470_26160 ENOG4105KVH Transcriptional regulator DY470_26170 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DY470_26175 ENOG4108KGH TRANSCRIPTIONal DY470_26180 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DY470_26185 ENOG4105C6Y Udp-glucose 6-dehydrogenase DY470_26190 ENOG4105ESV Glycosyl transferase, family 4 DY470_26200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DY470_26220 ENOG4105F8D glycoside hydrolase family 4 DY470_26225 ENOG4105VCP PTS System DY470_26230 ENOG4105CK1 PTS System DY470_26240 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DY470_26250 ENOG4105VCP PTS System DY470_26260 ENOG4105VZJ PTS System DY470_26275 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DY470_26300 ENOG4105ECB domain protein DY470_26305 ENOG4107RSM transcriptional regulator DY470_26335 ENOG4105DAA L-lactate DY470_26345 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DY470_26360 ENOG4105E0M Sulfatase DY470_26385 ENOG4107R8N Glycosyl transferase, family 2 DY470_26390 ENOG4105C94 Transporter DY470_26400 ENOG41069ER domain protein DY470_26425 ENOG4105KBK Zinc finger, swim domain protein DY470_26430 ENOG4105C0D helicase DY470_26460 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DY470_26475 ENOG4107RBB ABC transporter, permease DY470_26480 ENOG4105C19 ABC transporter DY470_26490 ENOG4105CXY transporter DY470_26505 ENOG4105BZU Histidine kinase DY470_26510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_26515 ENOG4105CMR udp-glucose 4-epimerase DY470_26535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DY470_26545 ENOG4105CG5 Glycosyl transferase (Group 1 DY470_26550 ENOG4107VDP teichoic acid biosynthesis DY470_26555 ENOG4107VDP teichoic acid biosynthesis DY470_26560 ENOG4105EY8 ABC transporter DY470_26570 ENOG4107SJB teichoic acid biosynthesis DY470_26575 ENOG4107RZX Teichoic acid biosynthesis protein DY470_26580 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DY470_26590 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DY470_26595 ENOG4107BJW polysaccharide deacetylase DY470_26605 ENOG4105FRN stage II sporulation protein DY470_26620 ENOG4105DY9 regulatoR DY470_26640 ENOG4106778 Protein of unknown function (DUF1146) DY470_26645 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DY470_26650 ENOG4105C8S subunit m DY470_26655 ENOG4105D65 subunit l DY470_26685 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY470_26695 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DY470_26700 ENOG4105BZU Histidine kinase DY470_26750 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DY470_26755 ENOG41062M3 atp synthase DY470_26785 ENOG4108YZG isomerase DY470_26800 ENOG4108VGI doxx family DY470_26805 ENOG4107XC4 flavin reductase domain protein, FMN-binding DY470_26825 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DY470_26835 ENOG4108ZXQ stage ii sporulation protein r DY470_26840 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DY470_26845 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DY470_26860 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DY470_26865 ENOG4105CBT Fructose-1,6-bisphosphatase DY470_26870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DY470_26905 ENOG4105C1G acyl-Coa dehydrogenase DY470_26910 ENOG4105C1G acyl-Coa dehydrogenase DY470_26915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DY470_26925 ENOG4105DF6 Fe-S oxidoreductase DY470_26940 ENOG4105BZU Histidine kinase DY470_26970 ENOG4105BZU Histidine kinase DY470_26975 ENOG4105KCT ABC transporter DY470_26980 ENOG4108M15 ABC transporter DY470_26985 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DY470_26995 ENOG4105IIU Aminopeptidase DY470_27015 ENOG4105JVQ RNA Polymerase DY470_27025 ENOG410684U Domain of unknown function (DUF1934) DY470_27045 ENOG4105CYW agmatinase DY470_27055 ENOG4105DXB Major Facilitator superfamily DY470_27060 ENOG4107SWG transcriptional regulator MERR family DY470_27065 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DY470_27070 ENOG4105BZ4 penicillin-binding protein DY470_27075 ENOG4108XFG YwhD family DY470_27080 ENOG4108Z4T Peptidase M50 DY470_27085 ENOG41069HH 4-oxalocrotonate tautomerase DY470_27090 ENOG4105DCI Phosphohydrolase DY470_27095 ENOG4108MES Periplasmic binding protein DY470_27100 ENOG4105E0A ABC, transporter DY470_27105 ENOG4105EHG Permease protein DY470_27110 ENOG4105DQ5 transport system permease protein DY470_27120 ENOG4108VCI transcription factor, rsfa family DY470_27135 ENOG4108IJ2 phosphate acetyltransferase DY470_27150 ENOG4108VKI Cell wall hydrolase DY470_27170 ENOG4107SVH Potassium channel protein DY470_27180 ENOG410667J hydrolase DY470_27185 ENOG4105VCH membrane DY470_27195 ENOG4108TU7 Inherit from COG: (ABC) transporter DY470_27200 ENOG4105CJ1 ABC, transporter DY470_27205 ENOG41090WU lipolytic protein G-D-S-L family DY470_27220 ENOG4105D6E homoserine dehydrogenase DY470_27240 ENOG4108Y4K DNA-binding transcriptional activator DY470_27250 ENOG4105WH1 Two component transcriptional regulator luxr family DY470_27255 ENOG4105BZU Histidine kinase DY470_27260 ENOG4105DWF phosphomethylpyrimidine kinase DY470_27265 ENOG4105BZU Histidine kinase DY470_27270 ENOG4105VCD cytoplasmic protein DY470_27275 ENOG4105D22 carbon starvation protein DY470_27280 ENOG4105DY9 regulatoR DY470_27285 ENOG41079KZ Major Facilitator Superfamily DY470_27305 ENOG4105EN6 Membrane DY470_27310 ENOG4106YBV Methyl-accepting chemotaxis DY470_27320 ENOG4108S4H thioesterase Superfamily protein DY470_27330 ENOG4105JEU Glycosyl transferase, family 2 DY470_27335 ENOG4105C5H ABC transporter DY470_27355 ENOG4105CKK Glycosyl transferase, family 2 DY470_27360 ENOG41067SE Tetr family transcriptional regulator DY470_27370 ENOG4105E0X reductase DY470_27375 ENOG4106F5Q Membrane DY470_27390 ENOG4105DY9 regulatoR DY470_27395 ENOG4108HRK Histidine kinase DY470_27400 ENOG4107RGD Major Facilitator superfamily DY470_27420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DY470_27430 ENOG4105IW1 AmiS UreI transporter DY470_27440 ENOG4105CMR udp-glucose 4-epimerase DY470_27445 ENOG4108UT2 hemolysin iii DY470_27455 ENOG4105C1J atp-dependent rna helicase DY470_27470 ENOG4105DPN Oligoendopeptidase f DY470_27490 ENOG4105C0H protease DY470_27495 ENOG4105Q2H domain protein DY470_27510 ENOG4105BZU Histidine kinase DY470_27515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DY470_27545 ENOG4105CDU Replicative dna helicase DY470_27555 ENOG4105BZR domain protein DY470_27560 ENOG4108XMW Membrane DY470_27570 ENOG4108UUM single-stranded DNA-binding protein DY470_27580 ENOG4105C3G gtp-binding protein DY470_27585 ENOG4105VDK protein, conserved in bacteria DY470_27590 ENOG4105D8X mechanosensitive ion channel DY470_27595 ENOG4108ZDA Sporulation protein YyaC DY470_27600 ENOG4105FA0 parb-like partition protein DY470_27605 ENOG4107QJE Chromosome Partitioning Protein DY470_27625 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DY470_27635 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins