locus-tag	class	description
L6174_00010	COG0592	DNA-directed DNA polymerase activity
L6174_00015	COG2501	S4 domain
L6174_00025	COG0187	DNA topoisomerase II activity
L6174_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6174_00065	COG0516	GMP reductase activity
L6174_00065	COG0517	IMP dehydrogenase activity
L6174_00070	COG1686	Belongs to the peptidase S11 family
L6174_00100	COG1428	Deoxynucleoside kinase
L6174_00105	COG1428	Deoxynucleoside kinase
L6174_00110	COG1335	isochorismatase
L6174_00115	COG0590	tRNA wobble adenosine to inosine editing
L6174_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6174_00180	COG1982	Orn Lys Arg decarboxylase major
L6174_00190	COG0470	DNA polymerase III
L6174_00195	COG1774	PSP1 C-terminal conserved region
L6174_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6174_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6174_00220	COG2002	toxin-antitoxin pair type II binding
L6174_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6174_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6174_00230	COG0084	hydrolase, TatD family'
L6174_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6174_00250	COG4466	Protein conserved in bacteria
L6174_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6174_00270	COG0251	oxidation-reduction process
L6174_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6174_00305	COG2002	toxin-antitoxin pair type II binding
L6174_00310	COG2244	polysaccharide biosynthetic process
L6174_00315	COG3956	TIGRFAM MazG family protein
L6174_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6174_00340	COG1098	S1 RNA binding domain
L6174_00355	COG2208	phosphoserine phosphatase activity
L6174_00360	COG0037	tRNA processing
L6174_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6174_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6174_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6174_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6174_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6174_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6174_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6174_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6174_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6174_00420	COG1396	sequence-specific DNA binding
L6174_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6174_00455	COG3880	PFAM UvrB UvrC protein
L6174_00465	COG0542	response to heat
L6174_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6174_00480	COG4956	integral membrane protein (PIN domain superfamily)
L6174_00500	COG1045	serine acetyltransferase
L6174_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6174_00520	COG3688	RNA-binding protein containing a PIN domain
L6174_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6174_00540	COG0250	Participates in transcription elongation, termination and antitermination
L6174_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6174_00565	COG2813	Specifically methylates the guanine in position
L6174_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6174_00580	COG1358	cellular component organization or biogenesis
L6174_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
L6174_00710	COG0201	protein transport
L6174_00720	COG0024	Methionine aminopeptidase
L6174_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6174_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6174_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6174_00795	COG0489	protein tyrosine kinase activity
L6174_00805	COG2194	sulfuric ester hydrolase activity
L6174_00810	COG0726	polysaccharide deacetylase
L6174_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6174_00895	COG4856	YbbR-like protein
L6174_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6174_00915	COG0596	Alpha beta hydrolase
L6174_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6174_00940	COG0823	Involved in the tonB-independent uptake of proteins
L6174_00940	COG1506	peptidase
L6174_00940	COG4946	Tricorn protease homolog
L6174_00975	COG2011	ABC-type metal ion transport system permease component
L6174_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6174_00985	COG1464	Belongs to the NlpA lipoprotein family
L6174_00990	COG0604	alcohol dehydrogenase
L6174_01000	COG0277	FAD linked oxidase domain protein
L6174_01005	COG2271	Major facilitator Superfamily
L6174_01015	COG2814	Major facilitator Superfamily
L6174_01030	COG0601	transmembrane transport
L6174_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6174_01040	COG0444	Belongs to the ABC transporter superfamily
L6174_01045	COG4608	Belongs to the ABC transporter superfamily
L6174_01050	COG4166	transmembrane transport
L6174_01060	COG2207	Transcriptional regulator
L6174_01075	COG4166	transmembrane transport
L6174_01080	COG4166	transmembrane transport
L6174_01085	COG0656	L-ascorbic acid biosynthetic process
L6174_01105	COG4149	molybdate abc transporter
L6174_01115	COG1910	domain protein
L6174_01125	COG0583	DNA-binding transcription factor activity
L6174_01130	COG0697	spore germination
L6174_01145	COG0204	Acyl-transferase
L6174_01155	COG1609	Transcriptional regulator
L6174_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_01175	COG0084	hydrolase, TatD family'
L6174_01180	COG5298	Protein conserved in bacteria
L6174_01205	COG0488	(ABC) transporter
L6174_01220	COG0747	negative chemotaxis
L6174_01225	COG0601	transmembrane transport
L6174_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6174_01235	COG0444	Belongs to the ABC transporter superfamily
L6174_01240	COG4608	Belongs to the ABC transporter superfamily
L6174_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6174_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6174_01290	COG2814	Major facilitator Superfamily
L6174_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6174_01310	COG4294	response to UV
L6174_01315	COG0457	Tetratricopeptide repeat
L6174_01315	COG0705	Rhomboid family
L6174_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6174_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6174_01335	COG0864	Transcriptional regulator
L6174_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6174_01345	COG2183	response to ionizing radiation
L6174_01440	COG0802	atpase or kinase
L6174_01445	COG1214	PFAM Peptidase M22, glycoprotease
L6174_01450	COG0456	acetyltransferase
L6174_01460	COG0488	(ABC) transporter
L6174_01475	COG1266	CAAX protease self-immunity
L6174_01495	COG2252	PERMEase
L6174_01535	COG2226	methyltransferase
L6174_01580	COG1968	undecaprenyl-diphosphatase activity
L6174_01595	COG2205	protein histidine kinase activity
L6174_01600	COG0745	RESPONSE REGULATOR receiver
L6174_01625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6174_01630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6174_01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6174_01645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6174_01660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6174_01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6174_01680	COG0151	Belongs to the GarS family
L6174_01705	COG0210	DNA helicase
L6174_01715	COG4851	CamS sex pheromone cAM373 precursor
L6174_01735	COG1335	isochorismatase
L6174_01740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6174_01745	COG2011	ABC-type metal ion transport system permease component
L6174_01750	COG1464	Belongs to the NlpA lipoprotein family
L6174_01775	COG1846	Transcriptional regulator
L6174_01800	COG1597	lipid kinase activity
L6174_01805	COG0546	phosphoglycolate phosphatase activity
L6174_01810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6174_01820	COG1012	belongs to the aldehyde dehydrogenase family
L6174_01825	COG2076	Multidrug Resistance protein
L6174_01830	COG2309	aminopeptidase activity
L6174_01845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_01850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6174_01855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6174_01865	COG4807	Protein conserved in bacteria
L6174_01890	COG1757	Na H antiporter
L6174_01895	COG1473	amidohydrolase
L6174_01910	COG0450	alkyl hydroperoxide reductase
L6174_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_01935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_01955	COG0166	Belongs to the GPI family
L6174_01990	COG5002	protein histidine kinase activity
L6174_02010	COG3541	Predicted nucleotidyltransferase
L6174_02015	COG2814	Major facilitator Superfamily
L6174_02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6174_02020	COG0723	plastoquinol--plastocyanin reductase activity
L6174_02030	COG0765	amino acid transport
L6174_02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6174_02045	COG0840	transmembrane signaling receptor activity
L6174_02050	COG0840	transmembrane signaling receptor activity
L6174_02055	COG0366	Alpha amylase catalytic
L6174_02060	COG1263	PTS System
L6174_02060	COG2190	(PTS) system
L6174_02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_02090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6174_02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6174_02115	COG1116	anion transmembrane transporter activity
L6174_02120	COG0488	(ABC) transporter
L6174_02165	COG2270	Major facilitator Superfamily
L6174_02180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6174_02195	COG2310	stress, protein
L6174_02200	COG2310	stress, protein
L6174_02205	COG2310	stress, protein
L6174_02210	COG0861	Integral membrane protein TerC family
L6174_02220	COG3853	Toxic anion resistance protein (TelA)
L6174_02235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6174_02245	COG1295	ribonuclease BN
L6174_02250	COG2217	Heavy metal translocating P-type atpase
L6174_02255	COG0697	spore germination
L6174_02275	COG0586	Pfam SNARE associated Golgi protein
L6174_02290	COG3871	stress protein (general stress protein 26)
L6174_02295	COG0387	Pfam Sodium calcium exchanger
L6174_02305	COG0535	radical SAM domain protein
L6174_02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6174_02335	COG0582	viral genome integration into host DNA
L6174_02345	COG1396	sequence-specific DNA binding
L6174_02360	COG1396	sequence-specific DNA binding
L6174_02395	COG1484	DNA-dependent DNA replication
L6174_02625	COG0101	tRNA pseudouridine synthase activity
L6174_02635	COG3829	transcription factor binding
L6174_02645	COG0833	amino acid
L6174_02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6174_02680	COG1263	PTS System
L6174_02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6174_02700	COG0463	Glycosyl transferase, family 2
L6174_02710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6174_02710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6174_02725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6174_02745	COG1228	amidohydrolase
L6174_02750	COG1090	epimerase
L6174_02780	COG1988	membrane-bound metal-dependent
L6174_02785	COG1194	a g-specific adenine glycosylase
L6174_02810	COG1132	(ABC) transporter
L6174_02815	COG4129	membrane
L6174_02820	COG0067	glutamate synthase
L6174_02820	COG0070	glutamate synthase
L6174_02820	COG0069	glutamate synthase activity
L6174_02830	COG4555	ABC transporter
L6174_02850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6174_02855	COG0735	belongs to the Fur family
L6174_02970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6174_02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6174_02985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6174_02995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6174_03005	COG2766	serine protein kinase
L6174_03025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6174_03035	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6174_03040	COG2268	Band 7 protein
L6174_03050	COG3290	protein histidine kinase activity
L6174_03055	COG4565	transcriptional regulatory protein
L6174_03060	COG2851	Citrate transporter
L6174_03080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6174_03085	COG3842	ATPase activity
L6174_03090	COG1175	transmembrane transport
L6174_03095	COG0395	ABC-type sugar transport system, permease component
L6174_03105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6174_03110	COG0745	RESPONSE REGULATOR receiver
L6174_03115	COG5002	protein histidine kinase activity
L6174_03125	COG4990	cell redox homeostasis
L6174_03135	COG3290	protein histidine kinase activity
L6174_03140	COG4565	transcriptional regulatory protein
L6174_03145	COG3493	citrate carrier protein
L6174_03150	COG0281	malic enzyme
L6174_03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_03175	COG5002	protein histidine kinase activity
L6174_03180	COG0745	RESPONSE REGULATOR receiver
L6174_03185	COG0456	acetyltransferase
L6174_03185	COG0454	-acetyltransferase
L6174_03190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6174_03195	COG3383	formate dehydrogenase (NAD+) activity
L6174_03215	COG0531	amino acid
L6174_03220	COG0640	Transcriptional regulator
L6174_03225	COG2217	Heavy metal translocating P-type atpase
L6174_03230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6174_03245	COG3227	Zinc metalloprotease (Elastase)
L6174_03265	COG2720	vancomycin resistance protein
L6174_03270	COG1316	TRANSCRIPTIONal
L6174_03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_03280	COG0346	lactoylglutathione lyase activity
L6174_03290	COG1027	Aspartate ammonia-lyase
L6174_03295	COG1620	l-lactate permease
L6174_03310	COG3104	oligopeptide transport
L6174_03315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_03335	COG2226	methyltransferase
L6174_03340	COG0156	8-amino-7-oxononanoate synthase activity
L6174_03360	COG0714	Associated with various cellular activities
L6174_03365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6174_03385	COG0531	amino acid
L6174_03390	COG2188	Transcriptional regulator
L6174_03395	COG1263	PTS System
L6174_03395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_03400	COG0366	Alpha amylase catalytic
L6174_03415	COG0697	spore germination
L6174_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6174_03430	COG1115	amino acid carrier protein
L6174_03435	COG1126	abc transporter atp-binding protein
L6174_03440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6174_03445	COG0765	amino acid transport
L6174_03450	COG0765	amino acid transport
L6174_03455	COG0833	amino acid
L6174_03480	COG2378	regulation of single-species biofilm formation
L6174_03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6174_03490	COG5002	protein histidine kinase activity
L6174_03505	COG0659	secondary active sulfate transmembrane transporter activity
L6174_03520	COG0747	negative chemotaxis
L6174_03530	COG0601	transmembrane transport
L6174_03535	COG4608	Belongs to the ABC transporter superfamily
L6174_03545	COG2271	Major facilitator Superfamily
L6174_03550	COG1846	Transcriptional regulator
L6174_03560	COG1609	Transcriptional regulator
L6174_03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6174_03580	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6174_03585	COG1879	ABC-type sugar transport system periplasmic component
L6174_03610	COG1063	alcohol dehydrogenase
L6174_03625	COG3568	Endonuclease Exonuclease Phosphatase
L6174_03650	COG1968	undecaprenyl-diphosphatase activity
L6174_03655	COG0840	transmembrane signaling receptor activity
L6174_03665	COG1476	TRANSCRIPTIONal
L6174_03680	COG3104	oligopeptide transport
L6174_03685	COG1114	Component of the transport system for branched-chain amino acids
L6174_03700	COG1113	amino acid transport
L6174_03705	COG2252	PERMEase
L6174_03730	COG0569	domain protein
L6174_03730	COG0475	glutathione-regulated potassium exporter activity
L6174_03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6174_03750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6174_03755	COG4990	cell redox homeostasis
L6174_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6174_03775	COG0697	spore germination
L6174_03780	COG0531	amino acid
L6174_03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6174_03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6174_03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6174_03800	COG1918	ferrous iron import across plasma membrane
L6174_03805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6174_03810	COG0573	inorganic phosphate transmembrane transporter activity
L6174_03815	COG0581	inorganic phosphate transmembrane transporter activity
L6174_03945	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6174_03965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6174_03970	COG1116	anion transmembrane transporter activity
L6174_03975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6174_03980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6174_03985	COG0352	thiamine-phosphate diphosphorylase activity
L6174_03990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6174_03995	COG2104	thiamine diphosphate biosynthetic process
L6174_04005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6174_04010	COG0351	phosphomethylpyrimidine kinase
L6174_04050	COG2205	protein histidine kinase activity
L6174_04055	COG2814	Major facilitator Superfamily
L6174_04060	COG1846	Transcriptional regulator
L6174_04075	COG2252	PERMEase
L6174_04080	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6174_04100	COG1621	beta-fructofuranosidase activity
L6174_04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_04105	COG1263	PTS System
L6174_04110	COG1609	Transcriptional regulator
L6174_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6174_04125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6174_04160	COG0778	Nitroreductase
L6174_04165	COG2719	SpoVR family
L6174_04190	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6174_04195	COG1937	Protein conserved in bacteria
L6174_04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6174_04200	COG0425	Belongs to the sulfur carrier protein TusA family
L6174_04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6174_04210	COG0425	Belongs to the sulfur carrier protein TusA family
L6174_04225	COG2210	Belongs to the sulfur carrier protein TusA family
L6174_04230	COG0730	response to heat
L6174_04240	COG1316	TRANSCRIPTIONal
L6174_04245	COG0604	alcohol dehydrogenase
L6174_04250	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6174_04265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6174_04265	COG3711	transcriptional antiterminator
L6174_04270	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6174_04275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6174_04295	COG1388	LysM domain
L6174_04295	COG3584	3D domain protein
L6174_04300	COG0577	efflux transmembrane transporter activity
L6174_04305	COG1136	(ABC) transporter
L6174_04315	COG5522	Integral membrane protein (intg_mem_TP0381)
L6174_04330	COG1114	Component of the transport system for branched-chain amino acids
L6174_04335	COG3546	catalase activity
L6174_04370	COG0586	Pfam SNARE associated Golgi protein
L6174_04405	COG0531	amino acid
L6174_04410	COG0475	glutathione-regulated potassium exporter activity
L6174_04420	COG1737	Transcriptional regulator
L6174_04430	COG1263	PTS System
L6174_04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_04440	COG2259	Doxx family
L6174_04455	COG0697	spore germination
L6174_04460	COG1522	sequence-specific DNA binding
L6174_04475	COG2076	Multidrug Resistance protein
L6174_04480	COG1309	transcriptional regulator
L6174_04485	COG2814	Major facilitator Superfamily
L6174_04490	COG1733	regulation of RNA biosynthetic process
L6174_04500	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6174_04505	COG4533	DNA binding
L6174_04510	COG2211	Major facilitator Superfamily
L6174_04520	COG0693	protein deglycase activity
L6174_04525	COG0753	catalase activity
L6174_04525	COG0693	protein deglycase activity
L6174_04535	COG0531	amino acid
L6174_04540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6174_04550	COG1012	belongs to the aldehyde dehydrogenase family
L6174_04555	COG1132	(ABC) transporter
L6174_04565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6174_04570	COG0765	amino acid transport
L6174_04575	COG1126	abc transporter atp-binding protein
L6174_04590	COG0189	ligase activity
L6174_04620	COG0028	Belongs to the TPP enzyme family
L6174_04625	COG3527	Alpha-acetolactate decarboxylase
L6174_04640	COG0561	phosphatase activity
L6174_04655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6174_04670	COG0659	secondary active sulfate transmembrane transporter activity
L6174_04690	COG0653	protein targeting
L6174_04695	COG2244	polysaccharide biosynthetic process
L6174_04705	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6174_04710	COG4196	transglutaminase domain protein
L6174_04725	COG1696	Membrane protein involved in D-alanine export
L6174_04740	COG1024	Enoyl-CoA hydratase
L6174_04760	COG1363	Peptidase, m42
L6174_04780	COG3938	Belongs to the proline racemase family
L6174_04820	COG0601	transmembrane transport
L6174_04825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6174_04835	COG4608	Belongs to the ABC transporter superfamily
L6174_04870	COG0477	Major facilitator Superfamily
L6174_04875	COG3290	protein histidine kinase activity
L6174_04880	COG4565	transcriptional regulatory protein
L6174_04885	COG3181	Tripartite tricarboxylate transporter family receptor
L6174_04915	COG0789	Transcriptional regulator
L6174_04915	COG4978	Transcriptional regulator
L6174_04930	COG0305	Participates in initiation and elongation during chromosome replication
L6174_04970	COG0477	Major facilitator Superfamily
L6174_05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6174_05015	COG3320	Male sterility
L6174_05020	COG1309	transcriptional regulator
L6174_05040	COG1183	phosphatidylcholine synthase activity
L6174_05060	COG2376	Dihydroxyacetone kinase
L6174_05070	COG2376	Dihydroxyacetone kinase
L6174_05075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6174_05080	COG1959	2 iron, 2 sulfur cluster binding
L6174_05110	COG2770	Histidine kinase
L6174_05110	COG3437	response regulator, receiver
L6174_05160	COG3237	CsbD-like
L6174_05185	COG1191	sigma factor activity
L6174_05195	COG2208	phosphoserine phosphatase activity
L6174_05200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6174_05205	COG2205	protein histidine kinase activity
L6174_05205	COG2198	Histidine kinase
L6174_05205	COG0784	Response regulator, receiver
L6174_05205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6174_05260	COG0420	3'-5' exonuclease activity
L6174_05285	COG1309	transcriptional regulator
L6174_05290	COG2814	Major facilitator Superfamily
L6174_05295	COG0346	lactoylglutathione lyase activity
L6174_05305	COG0457	Tetratricopeptide repeat
L6174_05310	COG2267	carboxylic ester hydrolase activity
L6174_05330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6174_05335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6174_05345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6174_05385	COG0477	Major facilitator Superfamily
L6174_05390	COG0477	Major facilitator Superfamily
L6174_05400	COG3973	AAA domain
L6174_05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6174_05425	COG4980	gas vesicle protein
L6174_05430	COG0537	adenosine 5'-monophosphoramidase activity
L6174_05435	COG1131	(ABC) transporter
L6174_05440	COG4473	ABC transporter
L6174_05455	COG1309	transcriptional regulator
L6174_05465	COG3402	PFAM membrane-flanked domain
L6174_05510	COG3402	PFAM membrane-flanked domain
L6174_05515	COG3428	Bacterial PH domain
L6174_05520	COG2329	Antibiotic biosynthesis monooxygenase
L6174_05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6174_05530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6174_05535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6174_05540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6174_05575	COG1309	transcriptional regulator
L6174_05580	COG1511	domain protein
L6174_05605	COG1609	Transcriptional regulator
L6174_05615	COG1234	tRNA 3'-trailer cleavage
L6174_05620	COG0095	Lipoate-protein ligase
L6174_05630	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_05660	COG3209	COG3209 Rhs family protein
L6174_05700	COG1078	dGTPase activity
L6174_05710	COG1595	DNA-templated transcription, initiation
L6174_05715	COG2207	Transcriptional regulator
L6174_05715	COG3708	Transcriptional regulator
L6174_05730	COG2205	protein histidine kinase activity
L6174_05735	COG0745	RESPONSE REGULATOR receiver
L6174_05760	COG0501	Belongs to the peptidase M48B family
L6174_05765	COG0840	transmembrane signaling receptor activity
L6174_05770	COG0697	spore germination
L6174_05790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6174_05795	COG2224	Isocitrate lyase
L6174_05820	COG4903	ComK protein
L6174_05825	COG0398	Pfam SNARE associated Golgi protein
L6174_05835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L6174_05840	COG1074	ATP-dependent DNA helicase activity
L6174_05885	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6174_05910	COG0367	asparagine synthase
L6174_05915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6174_05920	COG0753	catalase activity
L6174_05925	COG0004	ammonium transporteR
L6174_05945	COG2996	Protein conserved in bacteria
L6174_05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6174_05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_05980	COG0561	phosphatase activity
L6174_05990	COG0542	response to heat
L6174_06000	COG2267	carboxylic ester hydrolase activity
L6174_06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6174_06025	COG5504	Zn-dependent protease
L6174_06035	COG0180	Tryptophanyl-tRNA synthetase
L6174_06045	COG4166	transmembrane transport
L6174_06050	COG0601	transmembrane transport
L6174_06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6174_06060	COG0444	Belongs to the ABC transporter superfamily
L6174_06065	COG4608	Belongs to the ABC transporter superfamily
L6174_06070	COG0534	Mate efflux family protein
L6174_06075	COG4166	transmembrane transport
L6174_06090	COG0861	Integral membrane protein TerC family
L6174_06095	COG4862	establishment of competence for transformation
L6174_06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6174_06110	COG1164	Oligoendopeptidase f
L6174_06120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6174_06125	COG2346	COG2346, Truncated hemoglobins
L6174_06130	COG4116	CYTH
L6174_06140	COG2357	RelA SpoT domain protein
L6174_06150	COG0564	pseudouridine synthase activity
L6174_06170	COG0463	Glycosyl transferase, family 2
L6174_06170	COG1216	Glycosyl transferase, family 2
L6174_06190	COG0457	Tetratricopeptide repeat
L6174_06190	COG0463	Glycosyl transferase, family 2
L6174_06210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6174_06225	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6174_06270	COG2153	protein acetylation
L6174_06280	COG2382	esterase
L6174_06295	COG5492	domain, Protein
L6174_06300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6174_06310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6174_06310	COG0512	Glutamine amidotransferase of anthranilate synthase
L6174_06345	COG1620	l-lactate permease
L6174_06350	COG5634	Uncharacterized conserved protein (DUF2278)
L6174_06405	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6174_06415	COG1476	TRANSCRIPTIONal
L6174_06475	COG2226	methyltransferase
L6174_06485	COG1686	Belongs to the peptidase S11 family
L6174_06490	COG0681	Belongs to the peptidase S26 family
L6174_06525	COG1012	belongs to the aldehyde dehydrogenase family
L6174_06530	COG3842	ATPase activity
L6174_06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6174_06540	COG1177	transmembrane transport
L6174_06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6174_06555	COG2409	Drug exporters of the RND superfamily
L6174_06565	COG0564	pseudouridine synthase activity
L6174_06575	COG2340	Cysteine-rich secretory protein family
L6174_06580	COG0247	lactate metabolic process
L6174_06585	COG0277	FAD linked oxidase domain protein
L6174_06590	COG3835	regulator
L6174_06600	COG0745	RESPONSE REGULATOR receiver
L6174_06605	COG5002	protein histidine kinase activity
L6174_06610	COG2186	Transcriptional regulator
L6174_06630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6174_06640	COG2116	formate transmembrane transporter activity
L6174_06645	COG0861	Integral membrane protein TerC family
L6174_06650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6174_06660	COG2030	dehydratase
L6174_06680	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_06685	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6174_06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6174_06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6174_06710	COG1840	ABC-type Fe3 transport system, periplasmic component
L6174_06740	COG1349	DNA-binding transcription factor activity
L6174_06760	COG2861	carbohydrate metabolic process
L6174_06770	COG3852	Histidine kinase
L6174_06775	COG1846	Transcriptional regulator
L6174_06785	COG2318	DinB family
L6174_06795	COG5002	protein histidine kinase activity
L6174_06805	COG0720	synthase
L6174_06820	COG4873	Protein conserved in bacteria
L6174_06850	COG1780	Probably involved in ribonucleotide reductase function
L6174_06870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6174_06875	COG1725	Transcriptional regulator
L6174_06880	COG1131	(ABC) transporter
L6174_06890	COG1131	(ABC) transporter
L6174_06895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6174_06910	COG1522	sequence-specific DNA binding
L6174_06920	COG1335	isochorismatase
L6174_06930	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6174_06935	COG2070	2-Nitropropane dioxygenase
L6174_06940	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6174_06950	COG1696	Membrane protein involved in D-alanine export
L6174_06975	COG0716	FMN binding
L6174_06990	COG3173	Aminoglycoside phosphotransferase
L6174_07010	COG0534	Mate efflux family protein
L6174_07015	COG1968	undecaprenyl-diphosphatase activity
L6174_07030	COG1846	Transcriptional regulator
L6174_07040	COG1301	dicarboxylic acid transport
L6174_07045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6174_07050	COG4709	membrane
L6174_07055	COG3874	Sporulation protein YtfJ
L6174_07080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6174_07085	COG0028	Belongs to the TPP enzyme family
L6174_07090	COG0440	acetolactate synthase activity
L6174_07095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6174_07105	COG0473	3-isopropylmalate dehydrogenase activity
L6174_07130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6174_07165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6174_07180	COG1183	phosphatidylcholine synthase activity
L6174_07185	COG1368	sulfuric ester hydrolase activity
L6174_07195	COG0019	diaminopimelate decarboxylase activity
L6174_07215	COG0529	Catalyzes the synthesis of activated sulfate
L6174_07220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6174_07240	COG1648	precorrin-2 dehydrogenase activity
L6174_07245	COG0733	neurotransmitter:sodium symporter activity
L6174_07265	COG1757	Na H antiporter
L6174_07280	COG4758	membrane
L6174_07285	COG4585	Histidine kinase
L6174_07290	COG2197	response regulator
L6174_07300	COG1114	Component of the transport system for branched-chain amino acids
L6174_07310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6174_07335	COG1017	nitric oxide dioxygenase activity
L6174_07335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6174_07350	COG0730	response to heat
L6174_07355	COG0306	phosphate transporter
L6174_07360	COG1392	Phosphate transport regulator
L6174_07365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6174_07380	COG3852	Histidine kinase
L6174_07385	COG1801	Protein of unknown function DUF72
L6174_07395	COG0582	viral genome integration into host DNA
L6174_07400	COG5002	protein histidine kinase activity
L6174_07420	COG0392	lysyltransferase activity
L6174_07420	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6174_07435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6174_07440	COG1686	Belongs to the peptidase S11 family
L6174_07445	COG2715	membrane protein required for spore maturation
L6174_07450	COG0700	Nucleoside recognition
L6174_07455	COG1187	pseudouridine synthase activity
L6174_07465	COG1333	cytochrome c biogenesis protein
L6174_07470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6174_07475	COG0745	RESPONSE REGULATOR receiver
L6174_07480	COG5002	protein histidine kinase activity
L6174_07485	COG2096	Adenosyltransferase
L6174_07500	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6174_07505	COG1141	Ferredoxin
L6174_07510	COG4955	Helix-turn-helix domain
L6174_07515	COG0514	ATP-dependent DNA helicase (RecQ)
L6174_07520	COG1266	CAAX protease self-immunity
L6174_07540	COG4862	establishment of competence for transformation
L6174_07545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6174_07565	COG0492	ferredoxin-NADP+ reductase activity
L6174_07570	COG0252	asparaginase activity
L6174_07640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6174_07655	COG0142	geranyltranstransferase activity
L6174_07665	COG0142	geranyltranstransferase activity
L6174_07685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6174_07690	COG0457	Tetratricopeptide repeat
L6174_07710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6174_07720	COG4347	Protein of unknown function (DUF1405)
L6174_07735	COG2738	Putative neutral zinc metallopeptidase
L6174_07745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_07750	COG1694	Mazg nucleotide pyrophosphohydrolase
L6174_07765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6174_07770	COG0438	transferase activity, transferring glycosyl groups
L6174_07805	COG1199	ATP-dependent helicase activity
L6174_07805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6174_07825	COG3935	DnaD domain protein
L6174_07830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6174_07840	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6174_07840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6174_07900	COG0116	Belongs to the methyltransferase superfamily
L6174_07910	COG1199	ATP-dependent helicase activity
L6174_07915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6174_07925	COG3173	Aminoglycoside phosphotransferase
L6174_07930	COG0024	Methionine aminopeptidase
L6174_07940	COG2233	PERMEase
L6174_07945	COG2311	Membrane
L6174_07950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6174_07960	COG0456	acetyltransferase
L6174_08010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6174_08035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6174_08050	COG1215	transferase activity, transferring glycosyl groups
L6174_08055	COG0438	transferase activity, transferring glycosyl groups
L6174_08070	COG0454	-acetyltransferase
L6174_08090	COG0328	RNA-DNA hybrid ribonuclease activity
L6174_08130	COG1280	lysine exporter protein (LysE YggA)
L6174_08145	COG3162	membrane
L6174_08150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6174_08155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6174_08165	COG0475	glutathione-regulated potassium exporter activity
L6174_08170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6174_08175	COG0789	Transcriptional regulator
L6174_08175	COG4978	Transcriptional regulator
L6174_08185	COG2323	membrane
L6174_08190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6174_08245	COG1923	regulation of RNA biosynthetic process
L6174_08255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6174_08260	COG1360	Flagellar Motor Protein
L6174_08265	COG2201	protein-glutamate methylesterase activity
L6174_08275	COG1776	CheC inhibitor of MCP methylation
L6174_08275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6174_08290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6174_08310	COG1256	bacterial-type flagellum assembly
L6174_08335	COG1815	bacterial-type flagellum-dependent cell motility
L6174_08340	COG1558	bacterial-type flagellum-dependent cell motility
L6174_08355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6174_08365	COG1157	protein secretion by the type III secretion system
L6174_08400	COG0835	chemotaxis
L6174_08400	COG0784	Response regulator, receiver
L6174_08410	COG0463	Glycosyl transferase, family 2
L6174_08435	COG0463	Glycosyl transferase, family 2
L6174_08435	COG0457	Tetratricopeptide repeat
L6174_08450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6174_08455	COG0741	lytic transglycosylase activity
L6174_08470	COG1776	CheC inhibitor of MCP methylation
L6174_08470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6174_08480	COG1338	Plays a role in the flagellum-specific transport system
L6174_08485	COG1987	bacterial-type flagellum assembly
L6174_08495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6174_08500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6174_08505	COG1419	protein localization to endoplasmic reticulum
L6174_08510	COG4786	Flagellar basal body rod
L6174_08515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6174_08540	COG1309	transcriptional regulator
L6174_08560	COG2329	Antibiotic biosynthesis monooxygenase
L6174_08585	COG0583	DNA-binding transcription factor activity
L6174_08595	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6174_08605	COG1234	tRNA 3'-trailer cleavage
L6174_08630	COG1686	Belongs to the peptidase S11 family
L6174_08640	COG0406	alpha-ribazole phosphatase activity
L6174_08670	COG0367	asparagine synthase
L6174_08700	COG1802	Transcriptional regulator
L6174_08705	COG0697	spore germination
L6174_08710	COG0523	cobalamin synthesis protein
L6174_08715	COG0701	Predicted permease
L6174_08725	COG1216	Glycosyl transferase, family 2
L6174_08725	COG0438	transferase activity, transferring glycosyl groups
L6174_08730	COG1757	Na H antiporter
L6174_08735	COG0114	fumarate hydratase activity
L6174_08760	COG3340	Belongs to the peptidase S51 family
L6174_08780	COG0785	Cytochrome C biogenesis protein
L6174_08810	COG2733	membrane
L6174_08845	COG1131	(ABC) transporter
L6174_08860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6174_08865	COG0528	UMP kinase activity
L6174_08875	COG1027	Aspartate ammonia-lyase
L6174_08880	COG0281	malic enzyme
L6174_08885	COG4191	Histidine kinase
L6174_08890	COG0784	Response regulator, receiver
L6174_08895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6174_08955	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6174_08965	COG2814	Major facilitator Superfamily
L6174_08980	COG1966	Carbon starvation protein
L6174_08995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_09005	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6174_09015	COG2223	nitrite transmembrane transporter activity
L6174_09020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6174_09035	COG2244	polysaccharide biosynthetic process
L6174_09040	COG0733	neurotransmitter:sodium symporter activity
L6174_09050	COG5566	PFAM Mor transcription activator
L6174_09055	COG2323	membrane
L6174_09075	COG2084	Dehydrogenase
L6174_09090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6174_09100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6174_09105	COG0028	Belongs to the TPP enzyme family
L6174_09110	COG0440	acetolactate synthase activity
L6174_09115	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6174_09125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6174_09150	COG2814	Major facilitator Superfamily
L6174_09155	COG3384	dioxygenase
L6174_09165	COG3279	Response regulator of the LytR AlgR family
L6174_09170	COG0427	acetyl-CoA hydrolase
L6174_09190	COG1073	alpha beta
L6174_09220	COG0535	radical SAM domain protein
L6174_09225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_09245	COG1914	H( )-stimulated, divalent metal cation uptake system
L6174_09260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6174_09290	COG2390	Transcriptional regulator
L6174_09300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_09305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6174_09320	COG4224	UPF0291 protein
L6174_09340	COG0006	proline dipeptidase activity
L6174_09345	COG2132	Multicopper oxidase
L6174_09360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6174_09375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6174_09390	COG2372	response to copper ion
L6174_09390	COG1276	copper resistance
L6174_09395	COG4549	nuclear export factor GLE1
L6174_09405	COG0697	spore germination
L6174_09410	COG0583	DNA-binding transcription factor activity
L6174_09415	COG1959	2 iron, 2 sulfur cluster binding
L6174_09420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6174_09425	COG0778	Nitroreductase
L6174_09435	COG0628	permease
L6174_09445	COG1231	oxidoreductase activity
L6174_09450	COG0523	cobalamin synthesis protein
L6174_09465	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_09470	COG2030	dehydratase
L6174_09475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_09485	COG0411	ABC transporter
L6174_09505	COG0583	DNA-binding transcription factor activity
L6174_09515	COG1942	4-Oxalocrotonate Tautomerase
L6174_09525	COG1846	Transcriptional regulator
L6174_09535	COG1271	oxidase subunit
L6174_09540	COG1294	oxidase, subunit
L6174_09545	COG4988	ABC transporter
L6174_09550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6174_09570	COG1686	Belongs to the peptidase S11 family
L6174_09585	COG1388	LysM domain
L6174_09585	COG0791	NLP P60 protein
L6174_09600	COG0745	RESPONSE REGULATOR receiver
L6174_09605	COG5002	protein histidine kinase activity
L6174_09615	COG0300	oxidoreductase activity
L6174_09650	COG0460	homoserine dehydrogenase
L6174_09675	COG1316	TRANSCRIPTIONal
L6174_09685	COG0745	RESPONSE REGULATOR receiver
L6174_09690	COG5002	protein histidine kinase activity
L6174_09705	COG1285	pathogenesis
L6174_09710	COG1247	-acetyltransferase
L6174_09730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6174_09740	COG1082	Xylose isomerase domain protein TIM barrel
L6174_09755	COG1279	arginine transmembrane transporter activity
L6174_09765	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6174_09805	COG2002	toxin-antitoxin pair type II binding
L6174_09810	COG1404	Belongs to the peptidase S8 family
L6174_09815	COG0640	Transcriptional regulator
L6174_09820	COG0667	Aldo Keto reductase
L6174_09825	COG2814	Major facilitator Superfamily
L6174_09850	COG0840	transmembrane signaling receptor activity
L6174_09865	COG3949	Membrane
L6174_09870	COG0783	Belongs to the Dps family
L6174_09885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6174_09895	COG1231	oxidoreductase activity
L6174_09905	COG4989	oxidoreductase activity
L6174_09910	COG0523	cobalamin synthesis protein
L6174_09915	COG0456	acetyltransferase
L6174_09975	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6174_09975	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6174_09985	COG0702	epimerase
L6174_09995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6174_10005	COG4166	transmembrane transport
L6174_10020	COG0406	alpha-ribazole phosphatase activity
L6174_10030	COG5337	Spore coat protein CotH
L6174_10035	COG1051	belongs to the nudix hydrolase family
L6174_10040	COG0586	Pfam SNARE associated Golgi protein
L6174_10045	COG2244	polysaccharide biosynthetic process
L6174_10055	COG0701	Predicted permease
L6174_10060	COG3689	TIGRFAM TIGR03943 family protein
L6174_10065	COG1607	acyl-coa hydrolase
L6174_10075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6174_10090	COG0702	epimerase
L6174_10095	COG2839	Protein conserved in bacteria
L6174_10100	COG1253	flavin adenine dinucleotide binding
L6174_10115	COG1114	Component of the transport system for branched-chain amino acids
L6174_10120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6174_10140	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6174_10150	COG1876	peptidase activity
L6174_10160	COG0154	amidase activity
L6174_10165	COG2211	Major facilitator Superfamily
L6174_10185	COG0561	phosphatase activity
L6174_10195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6174_10200	COG4106	trans-aconitate 2-methyltransferase activity
L6174_10215	COG1819	glycosyl
L6174_10220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_10225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_10260	COG0456	acetyltransferase
L6174_10315	COG3874	Sporulation protein YtfJ
L6174_10340	COG2226	methyltransferase
L6174_10365	COG0346	lactoylglutathione lyase activity
L6174_10375	COG0604	alcohol dehydrogenase
L6174_10380	COG1595	DNA-templated transcription, initiation
L6174_10405	COG0386	Belongs to the glutathione peroxidase family
L6174_10410	COG1305	Transglutaminase-like
L6174_10415	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6174_10420	COG0714	Associated with various cellular activities
L6174_10435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6174_10440	COG1140	nitrate reductase beta subunit
L6174_10445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6174_10450	COG2181	nitrate reductase activity
L6174_10470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6174_10475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6174_10480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6174_10485	COG0303	'Molybdopterin
L6174_10490	COG0314	molybdopterin synthase activity
L6174_10500	COG2223	nitrite transmembrane transporter activity
L6174_10515	COG1648	precorrin-2 dehydrogenase activity
L6174_10525	COG1587	Uroporphyrinogen-III synthase
L6174_10525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6174_10530	COG2146	nitrite reductase [NAD(P)H] activity
L6174_10535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6174_10540	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6174_10575	COG2359	stage V sporulation protein S
L6174_10600	COG1418	mRNA catabolic process
L6174_10605	COG0488	(ABC) transporter
L6174_10620	COG0629	single-stranded DNA binding
L6174_10635	COG1413	lyase activity
L6174_10650	COG2136	Putative SAM-dependent methyltransferase
L6174_10650	COG2521	methyltransferase
L6174_10655	COG0018	arginyl-trna synthetase
L6174_10680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6174_10700	COG0017	Asparaginyl-tRNA synthetase
L6174_10720	COG1674	ftsk spoiiie
L6174_10790	COG1929	Belongs to the glycerate kinase type-1 family
L6174_10795	COG0471	metal ion transport
L6174_10800	COG0745	RESPONSE REGULATOR receiver
L6174_10805	COG3850	Histidine kinase
L6174_10805	COG5002	protein histidine kinase activity
L6174_10820	COG0733	neurotransmitter:sodium symporter activity
L6174_10845	COG2610	gluconate transmembrane transporter activity
L6174_10850	COG1454	alcohol dehydrogenase
L6174_10855	COG1794	racemase activity, acting on amino acids and derivatives
L6174_10865	COG0456	acetyltransferase
L6174_10880	COG1131	(ABC) transporter
L6174_10895	COG0546	phosphoglycolate phosphatase activity
L6174_10915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6174_10930	COG0768	penicillin binding
L6174_10935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6174_10940	COG0204	Acyl-transferase
L6174_10945	COG1272	protein, Hemolysin III
L6174_10955	COG0805	protein transport
L6174_10965	COG1307	EDD domain protein, DegV family
L6174_10970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6174_10975	COG1999	signal sequence binding
L6174_10980	COG0071	Belongs to the small heat shock protein (HSP20) family
L6174_10985	COG0367	asparagine synthase
L6174_11000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_11005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6174_11040	COG0668	transmembrane transport
L6174_11045	COG2203	Gaf domain
L6174_11045	COG4585	Histidine kinase
L6174_11050	COG2197	response regulator
L6174_11060	COG1064	alcohol dehydrogenase
L6174_11115	COG0517	IMP dehydrogenase activity
L6174_11115	COG1125	glycine betaine transport
L6174_11120	COG1174	glycine betaine transport
L6174_11155	COG1253	flavin adenine dinucleotide binding
L6174_11160	COG1012	belongs to the aldehyde dehydrogenase family
L6174_11165	COG5506	Protein of unknown function (DUF1694)
L6174_11180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6174_11185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6174_11190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6174_11195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6174_11200	COG0456	acetyltransferase
L6174_11205	COG3829	transcription factor binding
L6174_11210	COG1509	lysine 2,3-aminomutase activity
L6174_11250	COG4326	sporulation control protein
L6174_11255	COG0671	phosphoesterase, PA-phosphatase related
L6174_11260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6174_11265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6174_11295	COG1715	Restriction endonuclease
L6174_11295	COG1787	Restriction endonuclease
L6174_11385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6174_11435	COG2814	Major facilitator Superfamily
L6174_11440	COG4841	protein insertion into membrane
L6174_11445	COG0372	Belongs to the citrate synthase family
L6174_11450	COG2079	MmgE PrpD family protein
L6174_11455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6174_11460	COG1960	acyl-CoA dehydrogenase activity
L6174_11465	COG2084	Dehydrogenase
L6174_11475	COG1280	lysine exporter protein (LysE YggA)
L6174_11480	COG1024	Enoyl-CoA hydratase
L6174_11495	COG0420	3'-5' exonuclease activity
L6174_11500	COG0419	ATPase involved in DNA repair
L6174_11520	COG2223	nitrite transmembrane transporter activity
L6174_11525	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_11530	COG1169	isochorismate synthase
L6174_11535	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6174_11540	COG1535	isochorismatase
L6174_11540	COG3433	isochorismatase activity
L6174_11545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6174_11550	COG3251	PFAM MbtH domain protein
L6174_11555	COG2814	Major facilitator Superfamily
L6174_11570	COG0776	regulation of translation
L6174_11580	COG2318	DinB family
L6174_11590	COG1115	amino acid carrier protein
L6174_11605	COG2329	Antibiotic biosynthesis monooxygenase
L6174_11610	COG1187	pseudouridine synthase activity
L6174_11615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6174_11630	COG0596	Alpha beta hydrolase
L6174_11635	COG2814	Major facilitator Superfamily
L6174_11655	COG2226	methyltransferase
L6174_11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_11735	COG1247	-acetyltransferase
L6174_11765	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6174_11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_11785	COG1278	Cold shock
L6174_11800	COG0010	Belongs to the arginase family
L6174_11805	COG0561	phosphatase activity
L6174_11850	COG0583	DNA-binding transcription factor activity
L6174_11855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6174_11870	COG0583	DNA-binding transcription factor activity
L6174_11875	COG2258	MOSC domain
L6174_11890	COG1132	(ABC) transporter
L6174_11895	COG1132	(ABC) transporter
L6174_11915	COG1396	sequence-specific DNA binding
L6174_11940	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6174_11945	COG1595	DNA-templated transcription, initiation
L6174_11970	COG1649	PFAM Uncharacterised BCR, COG1649
L6174_11995	COG2971	BadF BadG BcrA BcrD
L6174_12000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6174_12005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6174_12025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_12055	COG1309	transcriptional regulator
L6174_12070	COG1136	(ABC) transporter
L6174_12070	COG0577	efflux transmembrane transporter activity
L6174_12075	COG0500	methyltransferase
L6174_12075	COG3615	Tellurite resistance protein tehB
L6174_12085	COG2226	methyltransferase
L6174_12090	COG3961	Belongs to the TPP enzyme family
L6174_12095	COG1846	Transcriptional regulator
L6174_12135	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6174_12150	COG1595	DNA-templated transcription, initiation
L6174_12160	COG0768	penicillin binding
L6174_12170	COG2367	Beta-lactamase
L6174_12175	COG0671	phosphoesterase, PA-phosphatase related
L6174_12185	COG2814	Major facilitator Superfamily
L6174_12190	COG0673	inositol 2-dehydrogenase activity
L6174_12200	COG1012	belongs to the aldehyde dehydrogenase family
L6174_12215	COG0191	fructose-bisphosphate aldolase activity
L6174_12220	COG3718	enzyme involved in inositol metabolism
L6174_12245	COG0457	Tetratricopeptide repeat
L6174_12250	COG1476	TRANSCRIPTIONal
L6174_12265	COG1876	peptidase activity
L6174_12285	COG1309	transcriptional regulator
L6174_12290	COG0488	(ABC) transporter
L6174_12305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_12320	COG1252	NADH dehydrogenase
L6174_12325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6174_12340	COG1131	(ABC) transporter
L6174_12350	COG1309	transcriptional regulator
L6174_12365	COG1960	acyl-CoA dehydrogenase activity
L6174_12370	COG0439	Biotin carboxylase
L6174_12375	COG0511	ligase activity, forming carbon-carbon bonds
L6174_12380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6174_12385	COG1024	Enoyl-CoA hydratase
L6174_12390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6174_12395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6174_12405	COG1247	-acetyltransferase
L6174_12410	COG0572	uridine kinase
L6174_12420	COG2318	DinB family
L6174_12425	COG1686	Belongs to the peptidase S11 family
L6174_12450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6174_12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6174_12490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6174_12515	COG2814	Major facilitator Superfamily
L6174_12535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6174_12555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_12570	COG1063	alcohol dehydrogenase
L6174_12600	COG3773	Cell wall hydrolase
L6174_12610	COG0745	RESPONSE REGULATOR receiver
L6174_12625	COG0488	(ABC) transporter
L6174_12640	COG1136	(ABC) transporter
L6174_12665	COG0460	homoserine dehydrogenase
L6174_12670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_12680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6174_12745	COG2124	cytochrome p450
L6174_12780	COG0561	phosphatase activity
L6174_12790	COG0768	penicillin binding
L6174_12795	COG1819	glycosyl
L6174_12800	COG1794	racemase activity, acting on amino acids and derivatives
L6174_12810	COG1122	ATPase activity
L6174_12825	COG2205	protein histidine kinase activity
L6174_12835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6174_12840	COG0604	alcohol dehydrogenase
L6174_12845	COG0768	penicillin binding
L6174_12855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6174_12890	COG0693	protein deglycase activity
L6174_12920	COG2814	Major facilitator Superfamily
L6174_12935	COG0584	glycerophosphoryl diester phosphodiesterase
L6174_12955	COG0697	spore germination
L6174_12985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6174_12995	COG2223	nitrite transmembrane transporter activity
L6174_13010	COG2816	NAD+ diphosphatase activity
L6174_13015	COG0592	DNA-directed DNA polymerase activity
L6174_13020	COG1051	belongs to the nudix hydrolase family
L6174_13055	COG3878	Protein conserved in bacteria
L6174_13105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6174_13120	COG0322	excinuclease ABC activity
L6174_13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6174_13185	COG1011	Hydrolase
L6174_13205	COG0076	glutamate decarboxylase activity
L6174_13220	COG1523	belongs to the glycosyl hydrolase 13 family
L6174_13225	COG3227	Zinc metalloprotease (Elastase)
L6174_13245	COG0201	protein transport
L6174_13255	COG0697	spore germination
L6174_13260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_13290	COG4129	membrane
L6174_13295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_13310	COG2959	enzyme of heme biosynthesis
L6174_13330	COG3483	tryptophan 2,3-dioxygenase activity
L6174_13335	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L6174_13340	COG3844	kynureninase activity
L6174_13345	COG1309	transcriptional regulator
L6174_13375	COG3284	Transcriptional regulator
L6174_13395	COG1349	DNA-binding transcription factor activity
L6174_13415	COG1959	2 iron, 2 sulfur cluster binding
L6174_13430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6174_13435	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6174_13440	COG0022	dehydrogenase e1 component
L6174_13445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6174_13455	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_13460	COG0456	acetyltransferase
L6174_13460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6174_13490	COG4176	ABC-type proline glycine betaine transport system permease component
L6174_13495	COG0517	IMP dehydrogenase activity
L6174_13495	COG4175	Glycine betaine
L6174_13520	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6174_13525	COG2153	protein acetylation
L6174_13530	COG3397	chitin binding
L6174_13545	COG2205	protein histidine kinase activity
L6174_13570	COG0658	competence protein
L6174_13570	COG2333	competence protein COMEC
L6174_13620	COG3973	AAA domain
L6174_13635	COG2105	PFAM AIG2 family protein
L6174_13640	COG0514	ATP-dependent DNA helicase (RecQ)
L6174_13660	COG4637	Psort location Cytoplasmic, score
L6174_13685	COG3397	chitin binding
L6174_13700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6174_13705	COG1115	amino acid carrier protein
L6174_13710	COG1012	belongs to the aldehyde dehydrogenase family
L6174_13715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6174_13725	COG3938	Belongs to the proline racemase family
L6174_13730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6174_13770	COG0586	Pfam SNARE associated Golgi protein
L6174_13785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6174_13790	COG0519	Catalyzes the synthesis of GMP from XMP
L6174_13795	COG4166	transmembrane transport
L6174_13805	COG4948	Mandelate Racemase Muconate Lactonizing
L6174_13850	COG2936	dipeptidyl-peptidase activity
L6174_13855	COG5002	protein histidine kinase activity
L6174_13905	COG1307	EDD domain protein, DegV family
L6174_13925	COG2814	Major facilitator Superfamily
L6174_13935	COG1664	Polymer-forming cytoskeletal
L6174_13940	COG0789	Transcriptional regulator
L6174_13945	COG4533	DNA binding
L6174_13950	COG0477	Major facilitator Superfamily
L6174_13950	COG2814	Major facilitator Superfamily
L6174_13970	COG2261	transglycosylase associated protein
L6174_13985	COG2226	methyltransferase
L6174_14020	COG0436	Aminotransferase
L6174_14025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6174_14030	COG5146	pantothenate kinase activity
L6174_14050	COG1131	(ABC) transporter
L6174_14095	COG0628	permease
L6174_14110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6174_14115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6174_14120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6174_14125	COG1116	anion transmembrane transporter activity
L6174_14145	COG2816	NAD+ diphosphatase activity
L6174_14165	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6174_14190	COG0697	spore germination
L6174_14195	COG2318	DinB family
L6174_14215	COG4912	Dna alkylation repair
L6174_14235	COG0861	Integral membrane protein TerC family
L6174_14240	COG1368	sulfuric ester hydrolase activity
L6174_14245	COG0488	(ABC) transporter
L6174_14260	COG1309	transcriptional regulator
L6174_14275	COG0287	Prephenate dehydrogenase
L6174_14280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6174_14285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6174_14290	COG1605	Chorismate mutase
L6174_14290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6174_14325	COG1388	LysM domain
L6174_14325	COG3584	3D domain protein
L6174_14335	COG1595	DNA-templated transcription, initiation
L6174_14360	COG1879	ABC-type sugar transport system periplasmic component
L6174_14370	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6174_14380	COG2390	Transcriptional regulator
L6174_14415	COG2329	Antibiotic biosynthesis monooxygenase
L6174_14435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_14445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L6174_14450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6174_14455	COG4187	Peptidase family M20/M25/M40
L6174_14460	COG1414	Transcriptional regulator
L6174_14465	COG0833	amino acid
L6174_14470	COG1690	Belongs to the RtcB family
L6174_14480	COG1785	Belongs to the alkaline phosphatase family
L6174_14490	COG3655	Transcriptional regulator
L6174_14505	COG4377	Putative membrane peptidase family (DUF2324)
L6174_14515	COG3279	Response regulator of the LytR AlgR family
L6174_14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_14530	COG0346	lactoylglutathione lyase activity
L6174_14550	COG0714	Associated with various cellular activities
L6174_14575	COG0463	Glycosyl transferase, family 2
L6174_14595	COG0463	Glycosyl transferase, family 2
L6174_14605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6174_14610	COG0753	catalase activity
L6174_14620	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6174_14645	COG0714	Associated with various cellular activities
L6174_14655	COG0778	Nitroreductase
L6174_14660	COG1846	Transcriptional regulator
L6174_14695	COG1725	Transcriptional regulator
L6174_14705	COG1136	(ABC) transporter
L6174_14705	COG0577	efflux transmembrane transporter activity
L6174_14730	COG2207	Transcriptional regulator
L6174_14735	COG0456	acetyltransferase
L6174_14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_14775	COG0642	Histidine kinase
L6174_14780	COG0745	RESPONSE REGULATOR receiver
L6174_14785	COG0596	Alpha beta hydrolase
L6174_14815	COG0730	response to heat
L6174_14825	COG0833	amino acid
L6174_14835	COG4335	DNA alkylation repair
L6174_14875	COG0768	penicillin binding
L6174_14885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6174_14920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6174_14925	COG1414	Transcriptional regulator
L6174_14940	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6174_14945	COG0640	Transcriptional regulator
L6174_14955	COG1960	acyl-CoA dehydrogenase activity
L6174_14970	COG3314	Sporulation integral membrane protein YlbJ
L6174_14985	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L6174_15000	COG3848	Pyruvate phosphate dikinase
L6174_15000	COG0574	Belongs to the PEP-utilizing enzyme family
L6174_15005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_15020	COG5577	PFAM Coat F domain
L6174_15025	COG3403	YqcI/YcgG family
L6174_15030	COG1280	lysine exporter protein (LysE YggA)
L6174_15065	COG1063	alcohol dehydrogenase
L6174_15080	COG1027	Aspartate ammonia-lyase
L6174_15085	COG0252	asparaginase activity
L6174_15090	COG1396	sequence-specific DNA binding
L6174_15100	COG0322	excinuclease ABC activity
L6174_15105	COG0531	amino acid
L6174_15110	COG1114	Component of the transport system for branched-chain amino acids
L6174_15115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6174_15125	COG0281	malic enzyme
L6174_15140	COG0531	amino acid
L6174_15150	COG0784	Response regulator, receiver
L6174_15160	COG2066	Belongs to the glutaminase family
L6174_15165	COG1115	amino acid carrier protein
L6174_15195	COG0737	Belongs to the 5'-nucleotidase family
L6174_15200	COG0753	catalase activity
L6174_15205	COG2267	carboxylic ester hydrolase activity
L6174_15210	COG1335	isochorismatase
L6174_15230	COG0583	DNA-binding transcription factor activity
L6174_15280	COG0415	Belongs to the DNA photolyase family
L6174_15285	COG0288	reversible hydration of carbon dioxide
L6174_15295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6174_15300	COG5609	conserved protein (DUF2294)
L6174_15315	COG1575	Belongs to the MenA family. Type 1 subfamily
L6174_15320	COG2267	carboxylic ester hydrolase activity
L6174_15325	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6174_15330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6174_15335	COG1121	(ABC) transporter
L6174_15365	COG0798	PFAM Bile acid sodium symporter
L6174_15370	COG0346	lactoylglutathione lyase activity
L6174_15375	COG0640	Transcriptional regulator
L6174_15390	COG0443	Heat shock 70 kDa protein
L6174_15405	COG1522	sequence-specific DNA binding
L6174_15420	COG0346	lactoylglutathione lyase activity
L6174_15440	COG2169	Transcriptional regulator
L6174_15445	COG2169	Transcriptional regulator
L6174_15490	COG2814	Major facilitator Superfamily
L6174_15515	COG0745	RESPONSE REGULATOR receiver
L6174_15520	COG5002	protein histidine kinase activity
L6174_15520	COG3850	Histidine kinase
L6174_15545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6174_15565	COG1476	TRANSCRIPTIONal
L6174_15580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_15585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6174_15595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_15600	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6174_15615	COG1136	(ABC) transporter
L6174_15620	COG0577	efflux transmembrane transporter activity
L6174_15635	COG5002	protein histidine kinase activity
L6174_15635	COG3850	Histidine kinase
L6174_15645	COG2364	Membrane
L6174_15650	COG1846	Transcriptional regulator
L6174_15660	COG2808	Putative FMN-binding domain
L6174_15665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_15670	COG2271	Major facilitator Superfamily
L6174_15675	COG1556	Lactate utilization protein
L6174_15680	COG1139	Iron-sulfur cluster binding protein
L6174_15690	COG0583	DNA-binding transcription factor activity
L6174_15700	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6174_15725	COG0673	inositol 2-dehydrogenase activity
L6174_15730	COG0561	phosphatase activity
L6174_15740	COG1609	Transcriptional regulator
L6174_15745	COG0457	Tetratricopeptide repeat
L6174_15765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6174_15795	COG0534	Mate efflux family protein
L6174_15815	COG2814	Major facilitator Superfamily
L6174_15820	COG1309	transcriptional regulator
L6174_15835	COG0814	amino acid
L6174_15840	COG1760	l-serine dehydratase
L6174_15845	COG1760	l-serine dehydratase
L6174_15855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6174_15860	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6174_15870	COG1335	isochorismatase
L6174_15875	COG1522	sequence-specific DNA binding
L6174_15880	COG0531	amino acid
L6174_15900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6174_15920	COG1595	DNA-templated transcription, initiation
L6174_15935	COG0662	Cupin 2, conserved barrel domain protein
L6174_15940	COG2207	Transcriptional regulator
L6174_15940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_15990	COG0477	Major facilitator Superfamily
L6174_16000	COG1846	Transcriptional regulator
L6174_16005	COG2814	Major facilitator Superfamily
L6174_16015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6174_16020	COG1131	(ABC) transporter
L6174_16040	COG2076	Multidrug Resistance protein
L6174_16045	COG1309	transcriptional regulator
L6174_16055	COG2031	fatty acid transporter
L6174_16065	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6174_16095	COG1122	ATPase activity
L6174_16100	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6174_16115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6174_16120	COG1288	antiporter activity
L6174_16125	COG2356	endonuclease I
L6174_16140	COG3620	sequence-specific DNA binding
L6174_16145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6174_16150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6174_16155	COG0124	histidyl-tRNA synthetase
L6174_16170	COG1733	regulation of RNA biosynthetic process
L6174_16175	COG0778	Nitroreductase
L6174_16195	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_16205	COG1131	(ABC) transporter
L6174_16230	COG1011	Hydrolase
L6174_16240	COG2365	Tyrosine phosphatase family
L6174_16265	COG0346	lactoylglutathione lyase activity
L6174_16270	COG1940	carbohydrate kinase activity
L6174_16275	COG0738	Major facilitator superfamily
L6174_16280	COG0110	maltose O-acetyltransferase activity
L6174_16290	COG0577	efflux transmembrane transporter activity
L6174_16290	COG1136	(ABC) transporter
L6174_16305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6174_16310	COG0628	permease
L6174_16330	COG2226	methyltransferase
L6174_16340	COG0477	Major facilitator Superfamily
L6174_16370	COG1253	flavin adenine dinucleotide binding
L6174_16375	COG0789	Transcriptional regulator
L6174_16380	COG0697	spore germination
L6174_16385	COG1357	PFAM Pentapeptide repeats (8 copies)
L6174_16390	COG3813	Protein conserved in bacteria
L6174_16395	COG2706	6-phosphogluconolactonase activity
L6174_16400	COG1070	Carbohydrate kinase
L6174_16410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6174_16415	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6174_16425	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6174_16430	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6174_16435	COG0604	alcohol dehydrogenase
L6174_16440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6174_16450	COG0604	alcohol dehydrogenase
L6174_16450	COG3321	synthase
L6174_16455	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_16480	COG0656	L-ascorbic acid biosynthetic process
L6174_16485	COG2814	Major facilitator Superfamily
L6174_16500	COG0346	lactoylglutathione lyase activity
L6174_16505	COG0814	amino acid
L6174_16530	COG1393	Belongs to the ArsC family
L6174_16535	COG1733	regulation of RNA biosynthetic process
L6174_16540	COG2188	Transcriptional regulator
L6174_16550	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6174_16555	COG1733	regulation of RNA biosynthetic process
L6174_16560	COG1733	regulation of RNA biosynthetic process
L6174_16575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_16595	COG0384	phenazine biosynthesis protein PhzF
L6174_16605	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_16615	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_16625	COG1733	regulation of RNA biosynthetic process
L6174_16655	COG1191	sigma factor activity
L6174_16670	COG1309	transcriptional regulator
L6174_16690	COG3152	Membrane
L6174_16715	COG1151	hydroxylamine reductase activity
L6174_16725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_16730	COG3757	hydrolase, family 25
L6174_16730	COG3409	Peptidoglycan-binding domain 1 protein
L6174_16765	COG2072	flavoprotein involved in K transport
L6174_16800	COG0604	alcohol dehydrogenase
L6174_16805	COG1113	amino acid transport
L6174_16810	COG2814	Major facilitator Superfamily
L6174_16840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6174_16845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6174_16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_16880	COG3739	integral membrane protein
L6174_16885	COG0384	phenazine biosynthesis protein PhzF
L6174_16915	COG0583	DNA-binding transcription factor activity
L6174_16935	COG1193	negative regulation of DNA recombination
L6174_16960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6174_16990	COG0584	glycerophosphoryl diester phosphodiesterase
L6174_17015	COG0640	Transcriptional regulator
L6174_17020	COG0604	alcohol dehydrogenase
L6174_17040	COG2808	Putative FMN-binding domain
L6174_17045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6174_17055	COG0385	Bile acid
L6174_17060	COG0277	FAD linked oxidase domain protein
L6174_17090	COG1216	Glycosyl transferase, family 2
L6174_17095	COG1024	Enoyl-CoA hydratase
L6174_17105	COG1285	pathogenesis
L6174_17120	COG2514	catechol 2,3-dioxygenase activity
L6174_17125	COG2720	vancomycin resistance protein
L6174_17165	COG0716	FMN binding
L6174_17195	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_17205	COG0165	Argininosuccinate lyase
L6174_17220	COG4145	pantothenate transmembrane transporter activity
L6174_17230	COG1012	belongs to the aldehyde dehydrogenase family
L6174_17235	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_17245	COG1657	PFAM Prenyltransferase squalene oxidase
L6174_17250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6174_17255	COG2962	Rard protein
L6174_17260	COG3326	Membrane
L6174_17275	COG0489	protein tyrosine kinase activity
L6174_17285	COG0314	molybdopterin synthase activity
L6174_17290	COG0303	'Molybdopterin
L6174_17295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6174_17300	COG2116	formate transmembrane transporter activity
L6174_17310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6174_17315	COG5609	conserved protein (DUF2294)
L6174_17320	COG2427	Protein of unknown function (DUF1641)
L6174_17325	COG3383	formate dehydrogenase (NAD+) activity
L6174_17335	COG0697	spore germination
L6174_17375	COG2226	methyltransferase
L6174_17380	COG4166	transmembrane transport
L6174_17390	COG4166	transmembrane transport
L6174_17395	COG1301	dicarboxylic acid transport
L6174_17400	COG1316	TRANSCRIPTIONal
L6174_17410	COG1595	DNA-templated transcription, initiation
L6174_17430	COG1131	(ABC) transporter
L6174_17440	COG0673	inositol 2-dehydrogenase activity
L6174_17445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6174_17450	COG0187	DNA topoisomerase II activity
L6174_17455	COG1832	CoA-binding protein
L6174_17460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6174_17465	COG0745	RESPONSE REGULATOR receiver
L6174_17480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6174_17485	COG4841	protein insertion into membrane
L6174_17490	COG0824	Thioesterase
L6174_17520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6174_17530	COG2274	protein secretion by the type I secretion system
L6174_17535	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6174_17575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6174_17590	COG0183	Belongs to the thiolase family
L6174_17595	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_17600	COG1268	BioY protein
L6174_17605	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_17655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_17665	COG5002	protein histidine kinase activity
L6174_17670	COG0400	carboxylic ester hydrolase activity
L6174_17675	COG0346	lactoylglutathione lyase activity
L6174_17680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6174_17685	COG0069	glutamate synthase activity
L6174_17690	COG1902	pentaerythritol trinitrate reductase activity
L6174_17695	COG1329	Transcriptional regulator
L6174_17700	COG0010	Belongs to the arginase family
L6174_17725	COG2226	methyltransferase
L6174_17760	COG4846	Membrane protein involved in cytochrome C biogenesis
L6174_17765	COG0785	Cytochrome C biogenesis protein
L6174_17775	COG0583	DNA-binding transcription factor activity
L6174_17780	COG1380	Effector of murein hydrolase LrgA
L6174_17785	COG1346	cytolysis
L6174_17810	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6174_17810	COG3409	Peptidoglycan-binding domain 1 protein
L6174_17825	COG1132	(ABC) transporter
L6174_17830	COG1132	(ABC) transporter
L6174_17860	COG3639	organic phosphonate transmembrane transporter activity
L6174_17865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6174_17885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6174_17905	COG1695	Transcriptional regulator
L6174_17945	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6174_17945	COG3409	Peptidoglycan-binding domain 1 protein
L6174_17945	COG1388	LysM domain
L6174_17950	COG4824	toxin secretion phage lysis holin
L6174_18105	COG1595	DNA-templated transcription, initiation
L6174_18150	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L6174_18230	COG1396	sequence-specific DNA binding
L6174_18255	COG0174	glutamine synthetase
L6174_18260	COG0789	Transcriptional regulator
L6174_18265	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6174_18275	COG2860	membrane
L6174_18280	COG0464	growth
L6174_18310	COG1388	LysM domain
L6174_18310	COG3584	3D domain protein
L6174_18315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6174_18315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6174_18315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6174_18320	COG1105	Belongs to the carbohydrate kinase PfkB family
L6174_18325	COG1349	DNA-binding transcription factor activity
L6174_18335	COG2322	membrane
L6174_18345	COG1113	amino acid transport
L6174_18360	COG1408	metallophosphoesterase
L6174_18365	COG2116	formate transmembrane transporter activity
L6174_18375	COG2217	Heavy metal translocating P-type atpase
L6174_18380	COG2608	mercury ion transmembrane transporter activity
L6174_18385	COG1937	Protein conserved in bacteria
L6174_18395	COG2819	hydrolase of the alpha beta superfamily
L6174_18400	COG1120	ATPase activity
L6174_18405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_18410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_18420	COG0708	Exodeoxyribonuclease III
L6174_18425	COG2169	Transcriptional regulator
L6174_18430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6174_18435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6174_18445	COG2364	Membrane
L6174_18460	COG2267	carboxylic ester hydrolase activity
L6174_18465	COG0346	lactoylglutathione lyase activity
L6174_18470	COG3300	MHYT domain
L6174_18470	COG5001	Diguanylate cyclase
L6174_18490	COG1346	cytolysis
L6174_18495	COG1380	Effector of murein hydrolase LrgA
L6174_18500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6174_18505	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6174_18505	COG0596	Alpha beta hydrolase
L6174_18510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6174_18530	COG1404	Belongs to the peptidase S8 family
L6174_18535	COG3773	Cell wall hydrolase
L6174_18540	COG0562	UDP-galactopyranose mutase
L6174_18545	COG1368	sulfuric ester hydrolase activity
L6174_18550	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6174_18560	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6174_18585	COG1131	(ABC) transporter
L6174_18605	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6174_18610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6174_18615	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6174_18620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6174_18620	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6174_18630	COG2359	stage V sporulation protein S
L6174_18635	COG1692	metallophosphoesterase
L6174_18660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6174_18665	COG1426	Protein conserved in bacteria
L6174_18680	COG0300	oxidoreductase activity
L6174_18685	COG0612	Peptidase, M16
L6174_18690	COG0612	Peptidase, M16
L6174_18695	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6174_18705	COG3845	ABC transporter
L6174_18710	COG1744	ABC transporter substrate-binding protein PnrA-like
L6174_18715	COG2188	Transcriptional regulator
L6174_18720	COG1674	ftsk spoiiie
L6174_18730	COG0740	serine-type endopeptidase activity
L6174_18735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6174_18745	COG0527	aspartate kinase activity
L6174_18750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6174_18755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6174_18760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6174_18765	COG1873	PFAM PRC-barrel domain
L6174_18770	COG0612	Peptidase, M16
L6174_18775	COG0726	polysaccharide deacetylase
L6174_18790	COG0196	riboflavin kinase activity
L6174_18795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6174_18805	COG1550	Protein conserved in bacteria
L6174_18815	COG1358	cellular component organization or biogenesis
L6174_18820	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6174_18825	COG0195	Participates in both transcription termination and antitermination
L6174_18845	COG0750	zinc metalloprotease
L6174_18855	COG4589	Belongs to the CDS family
L6174_18860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6174_18870	COG0528	UMP kinase activity
L6174_18900	COG4974	Belongs to the 'phage' integrase family
L6174_18910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6174_18920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6174_18960	COG1837	Belongs to the UPF0109 family
L6174_18970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6174_18980	COG0552	protein localization to endoplasmic reticulum
L6174_18985	COG1196	nuclear chromosome segregation
L6174_18995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6174_19000	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_19005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6174_19020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6174_19025	COG1461	Dihydroxyacetone kinase
L6174_19030	COG1302	Protein conserved in bacteria
L6174_19045	COG1564	THIamine pyrophosphokinase
L6174_19050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6174_19055	COG1162	GTPase activity
L6174_19060	COG0515	serine threonine protein kinase
L6174_19060	COG2815	serine threonine protein kinase
L6174_19065	COG0631	protein serine/threonine phosphatase activity
L6174_19075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6174_19075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6174_19085	COG0242	peptide deformylase activity
L6174_19090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6174_19095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6174_19115	COG1561	YicC-like family, N-terminal region
L6174_19120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6174_19130	COG0006	proline dipeptidase activity
L6174_19145	COG3069	C4-dicarboxylate transmembrane transporter activity
L6174_19210	COG0564	pseudouridine synthase activity
L6174_19230	COG3599	regulation of cell shape
L6174_19235	COG2302	S4 RNA-binding domain
L6174_19240	COG0762	integral membrane protein
L6174_19250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6174_19255	COG1496	oxidoreductase activity
L6174_19260	COG1873	PFAM PRC-barrel domain
L6174_19265	COG1191	sigma factor activity
L6174_19270	COG1191	sigma factor activity
L6174_19280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6174_19285	COG0849	cell division
L6174_19290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6174_19295	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6174_19305	COG0772	Belongs to the SEDS family
L6174_19320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6174_19325	COG0768	penicillin binding
L6174_19330	COG0768	penicillin binding
L6174_19335	COG4839	cell division protein FtsL
L6174_19350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6174_19365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6174_19370	COG1399	metal-binding, possibly nucleic acid-binding protein
L6174_19420	COG4824	toxin secretion phage lysis holin
L6174_19515	COG4626	Terminase
L6174_19515	COG1802	Transcriptional regulator
L6174_19540	COG0582	viral genome integration into host DNA
L6174_19605	COG0756	dUTP diphosphatase activity
L6174_19620	COG1191	sigma factor activity
L6174_19645	COG1484	DNA-dependent DNA replication
L6174_19675	COG1396	sequence-specific DNA binding
L6174_19690	COG1396	sequence-specific DNA binding
L6174_19705	COG0582	viral genome integration into host DNA
L6174_19715	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6174_19720	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6174_19725	COG3314	Sporulation integral membrane protein YlbJ
L6174_19735	COG0742	ribosomal rna small subunit methyltransferase
L6174_19750	COG3679	Belongs to the UPF0342 family
L6174_19755	COG0406	alpha-ribazole phosphatase activity
L6174_19770	COG2340	Cysteine-rich secretory protein family
L6174_19785	COG3336	cytochrome c oxidase
L6174_19820	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6174_19825	COG0772	Belongs to the SEDS family
L6174_19835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6174_19840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6174_19850	COG4896	Protein conserved in bacteria
L6174_19865	COG1217	gtp-binding protein TYPA
L6174_19875	COG0483	inositol monophosphate 1-phosphatase activity
L6174_19895	COG1982	Orn Lys Arg decarboxylase major
L6174_19940	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6174_19945	COG0022	dehydrogenase e1 component
L6174_19950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6174_19960	COG0242	peptide deformylase activity
L6174_19965	COG0561	phosphatase activity
L6174_19975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6174_19980	COG0569	domain protein
L6174_20000	COG0583	DNA-binding transcription factor activity
L6174_20005	COG0517	IMP dehydrogenase activity
L6174_20015	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6174_20025	COG4703	Protein of unknown function (DUF1797)
L6174_20040	COG2200	EAL domain
L6174_20045	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_20050	COG1408	metallophosphoesterase
L6174_20060	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6174_20095	COG2814	Major facilitator Superfamily
L6174_20115	COG3209	COG3209 Rhs family protein
L6174_20125	COG2205	protein histidine kinase activity
L6174_20135	COG0436	Aminotransferase
L6174_20140	COG1609	Transcriptional regulator
L6174_20145	COG3833	ABC-type maltose transport systems, permease component
L6174_20150	COG1175	transmembrane transport
L6174_20155	COG2182	Extracellular solute-binding protein
L6174_20165	COG0366	Alpha amylase catalytic
L6174_20170	COG3842	ATPase activity
L6174_20210	COG0183	Belongs to the thiolase family
L6174_20245	COG1695	Transcriptional regulator
L6174_20250	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_20260	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L6174_20270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6174_20275	COG0436	Aminotransferase
L6174_20295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L6174_20315	COG2199	diguanylate cyclase activity
L6174_20320	COG0778	Nitroreductase
L6174_20345	COG1263	PTS System
L6174_20345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6174_20345	COG2190	(PTS) system
L6174_20350	COG3711	transcriptional antiterminator
L6174_20360	COG2188	Transcriptional regulator
L6174_20370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6174_20395	COG1547	Domain of unknown function (DUF309)
L6174_20400	COG0456	acetyltransferase
L6174_20410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6174_20415	COG4086	secreted protein
L6174_20420	COG0561	phosphatase activity
L6174_20425	COG0697	spore germination
L6174_20440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_20465	COG0733	neurotransmitter:sodium symporter activity
L6174_20485	COG1686	Belongs to the peptidase S11 family
L6174_20490	COG1725	Transcriptional regulator
L6174_20495	COG1131	(ABC) transporter
L6174_20510	COG1846	Transcriptional regulator
L6174_20525	COG0598	Magnesium transport protein CorA
L6174_20550	COG4974	Belongs to the 'phage' integrase family
L6174_20560	COG0735	belongs to the Fur family
L6174_20565	COG1300	Membrane
L6174_20585	COG0667	Aldo Keto reductase
L6174_20590	COG0656	L-ascorbic acid biosynthetic process
L6174_20595	COG0456	acetyltransferase
L6174_20595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6174_20605	COG0737	Belongs to the 5'-nucleotidase family
L6174_20605	COG1525	nuclease
L6174_20605	COG4085	toxin activity
L6174_20615	COG0596	Alpha beta hydrolase
L6174_20620	COG2056	Na+-H+ antiporter family
L6174_20625	COG1609	Transcriptional regulator
L6174_20630	COG0456	acetyltransferase
L6174_20635	COG1073	alpha beta
L6174_20650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6174_20650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6174_20655	COG0307	riboflavin synthase, alpha
L6174_20680	COG4106	trans-aconitate 2-methyltransferase activity
L6174_20685	COG1073	alpha beta
L6174_20685	COG2226	methyltransferase
L6174_20700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6174_20710	COG1757	Na H antiporter
L6174_20715	COG0737	Belongs to the 5'-nucleotidase family
L6174_20725	COG1522	sequence-specific DNA binding
L6174_20745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6174_20755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6174_20770	COG0300	oxidoreductase activity
L6174_20780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6174_20785	COG1760	l-serine dehydratase
L6174_20790	COG1760	l-serine dehydratase
L6174_20810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6174_20820	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6174_20825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_20840	COG1376	ErfK ybiS ycfS ynhG family protein
L6174_20845	COG4129	membrane
L6174_20850	COG1126	abc transporter atp-binding protein
L6174_20855	COG0765	amino acid transport
L6174_20860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6174_20875	COG2816	NAD+ diphosphatase activity
L6174_20880	COG0772	Belongs to the SEDS family
L6174_20885	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6174_20890	COG0022	dehydrogenase e1 component
L6174_20895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6174_20900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6174_20915	COG0280	phosphate acetyltransferase
L6174_20920	COG3829	transcription factor binding
L6174_20920	COG3290	protein histidine kinase activity
L6174_20930	COG0584	glycerophosphoryl diester phosphodiesterase
L6174_20935	COG3093	addiction module antidote protein HigA
L6174_20945	COG0745	RESPONSE REGULATOR receiver
L6174_20950	COG0750	zinc metalloprotease
L6174_20955	COG0497	DNA recombination
L6174_20965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6174_20975	COG0142	geranyltranstransferase activity
L6174_21000	COG1302	Protein conserved in bacteria
L6174_21005	COG0439	Biotin carboxylase
L6174_21010	COG0511	ligase activity, forming carbon-carbon bonds
L6174_21055	COG3854	ATPases associated with a variety of cellular activities
L6174_21080	COG0006	proline dipeptidase activity
L6174_21095	COG3872	metal-dependent enzyme
L6174_21105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6174_21125	COG0095	Lipoate-protein ligase
L6174_21130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6174_21135	COG1609	Transcriptional regulator
L6174_21145	COG2076	Multidrug Resistance protein
L6174_21150	COG2076	Multidrug Resistance protein
L6174_21190	COG1725	Transcriptional regulator
L6174_21220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6174_21275	COG4970	Tfp pilus assembly protein FimT
L6174_21285	COG1459	type II secretion system
L6174_21290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6174_21340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6174_21345	COG1410	methionine synthase
L6174_21345	COG0646	methionine synthase
L6174_21350	COG0646	methionine synthase
L6174_21350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6174_21355	COG0626	cystathionine gamma-synthase activity
L6174_21360	COG0626	cystathionine gamma-synthase activity
L6174_21380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_21390	COG1940	carbohydrate kinase activity
L6174_21395	COG4483	Protein conserved in bacteria
L6174_21400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6174_21405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6174_21410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6174_21415	COG0704	Plays a role in the regulation of phosphate uptake
L6174_21425	COG0581	inorganic phosphate transmembrane transporter activity
L6174_21430	COG0573	inorganic phosphate transmembrane transporter activity
L6174_21435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6174_21440	COG0768	penicillin binding
L6174_21445	COG0477	Major facilitator Superfamily
L6174_21450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6174_21475	COG0735	belongs to the Fur family
L6174_21480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6174_21485	COG1121	(ABC) transporter
L6174_21490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_21520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6174_21525	COG2384	SAM-dependent methyltransferase
L6174_21530	COG2010	Cytochrome c
L6174_21535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6174_21540	COG0358	DNA primase activity
L6174_21550	COG0517	IMP dehydrogenase activity
L6174_21565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6174_21570	COG0295	cytidine deaminase activity
L6174_21575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6174_21590	COG1702	phosphate starvation-inducible protein PhoH
L6174_21605	COG1610	YqeY-like protein
L6174_21610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6174_21615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6174_21620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6174_21650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6174_21655	COG1733	regulation of RNA biosynthetic process
L6174_21680	COG1466	dna polymerase III delta subunit
L6174_21690	COG2333	competence protein COMEC
L6174_21690	COG0658	competence protein
L6174_21695	COG2131	deaminase
L6174_21700	COG1596	polysaccharide export
L6174_21700	COG1555	photosystem II stabilization
L6174_21705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6174_21710	COG2226	methyltransferase
L6174_21715	COG0799	negative regulation of ribosome biogenesis
L6174_21720	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6174_21730	COG1534	Rna-binding protein
L6174_21740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6174_21745	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6174_21770	COG1595	DNA-templated transcription, initiation
L6174_21780	COG0778	Nitroreductase
L6174_21785	COG2357	RelA SpoT domain protein
L6174_21795	COG1785	Belongs to the alkaline phosphatase family
L6174_21805	COG2267	carboxylic ester hydrolase activity
L6174_21840	COG1404	Belongs to the peptidase S8 family
L6174_21845	COG3186	Phenylalanine-4-hydroxylase
L6174_21860	COG2259	Doxx family
L6174_21900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_21910	COG1454	alcohol dehydrogenase
L6174_21910	COG1012	belongs to the aldehyde dehydrogenase family
L6174_21915	COG0626	cystathionine gamma-synthase activity
L6174_21920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6174_21945	COG0768	penicillin binding
L6174_21960	COG0826	peptidase U32
L6174_21965	COG0826	peptidase U32
L6174_21970	COG4122	O-methyltransferase activity
L6174_21975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6174_21995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6174_22005	COG0628	permease
L6174_22025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6174_22035	COG0482	sulfurtransferase activity
L6174_22040	COG1104	cysteine desulfurase activity
L6174_22045	COG1959	2 iron, 2 sulfur cluster binding
L6174_22050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6174_22060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6174_22085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6174_22095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6174_22095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6174_22100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6174_22105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6174_22105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6174_22115	COG2244	polysaccharide biosynthetic process
L6174_22120	COG2323	membrane
L6174_22130	COG1862	Preprotein translocase
L6174_22160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6174_22170	COG0697	spore germination
L6174_22175	COG0697	spore germination
L6174_22180	COG0640	Transcriptional regulator
L6174_22205	COG0157	Belongs to the NadC ModD family
L6174_22210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6174_22215	COG1104	cysteine desulfurase activity
L6174_22220	COG1827	regulation of RNA biosynthetic process
L6174_22225	COG2258	MOSC domain
L6174_22230	COG0077	Prephenate dehydratase
L6174_22235	COG0577	efflux transmembrane transporter activity
L6174_22240	COG0577	efflux transmembrane transporter activity
L6174_22245	COG1136	(ABC) transporter
L6174_22255	COG0745	RESPONSE REGULATOR receiver
L6174_22260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6174_22265	COG3290	protein histidine kinase activity
L6174_22275	COG2868	ribosomal protein
L6174_22285	COG1530	ribonuclease E activity
L6174_22290	COG1994	Peptidase M50
L6174_22295	COG0739	heme binding
L6174_22300	COG2894	cell division
L6174_22320	COG1077	Cell shape determining protein MreB Mrl
L6174_22340	COG0285	dihydrofolate synthase activity
L6174_22345	COG0525	valine-tRNA ligase activity
L6174_22355	COG1388	LysM domain
L6174_22365	COG0113	porphobilinogen synthase activity
L6174_22370	COG1587	Uroporphyrinogen-III synthase
L6174_22380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6174_22390	COG1846	Transcriptional regulator
L6174_22395	COG1764	response to oxidative stress
L6174_22410	COG1067	ATP-dependent peptidase activity
L6174_22410	COG0470	DNA polymerase III
L6174_22455	COG0622	Phosphoesterase
L6174_22470	COG5401	PFAM Sporulation and spore germination
L6174_22490	COG1309	transcriptional regulator
L6174_22505	COG2197	response regulator
L6174_22510	COG2233	PERMEase
L6174_22520	COG0402	S-adenosylhomocysteine deaminase activity
L6174_22525	COG0402	S-adenosylhomocysteine deaminase activity
L6174_22535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6174_22545	COG0444	Belongs to the ABC transporter superfamily
L6174_22550	COG4608	Belongs to the ABC transporter superfamily
L6174_22555	COG3275	phosphorelay sensor kinase activity
L6174_22560	COG3279	Response regulator of the LytR AlgR family
L6174_22575	COG1983	PspC domain protein
L6174_22580	COG1396	sequence-specific DNA binding
L6174_22585	COG0697	spore germination
L6174_22595	COG1959	2 iron, 2 sulfur cluster binding
L6174_22600	COG1668	transmembrane transport
L6174_22605	COG4152	abc transporter atp-binding protein
L6174_22610	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6174_22620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6174_22625	COG1876	peptidase activity
L6174_22630	COG0824	Thioesterase
L6174_22635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6174_22640	COG1053	succinate dehydrogenase
L6174_22645	COG2009	succinate dehydrogenase
L6174_22650	COG1719	4-vinyl reductase, 4VR
L6174_22660	COG3118	belongs to the thioredoxin family
L6174_22665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6174_22670	COG2086	electron transfer activity
L6174_22675	COG1024	Enoyl-CoA hydratase
L6174_22685	COG0318	PFAM AMP-dependent synthetase and ligase
L6174_22705	COG2318	DinB family
L6174_22735	COG1131	(ABC) transporter
L6174_22740	COG2205	protein histidine kinase activity
L6174_22745	COG0745	RESPONSE REGULATOR receiver
L6174_22755	COG4895	conserved protein (DUF2196)
L6174_22760	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6174_22775	COG4509	Sortase family
L6174_22780	COG1120	ATPase activity
L6174_22795	COG5386	Cell surface protein
L6174_22805	COG5386	Cell surface protein
L6174_22810	COG1114	Component of the transport system for branched-chain amino acids
L6174_22815	COG1187	pseudouridine synthase activity
L6174_22825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6174_22825	COG1796	DNA polymerase
L6174_22830	COG1286	toxin biosynthetic process
L6174_22875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6174_22885	COG1418	mRNA catabolic process
L6174_22910	COG2814	Major facilitator Superfamily
L6174_22915	COG1566	PFAM secretion protein HlyD family protein
L6174_22920	COG1309	transcriptional regulator
L6174_22925	COG1363	Peptidase, m42
L6174_22950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6174_22960	COG1484	DNA-dependent DNA replication
L6174_22965	COG3611	Membrane attachment protein
L6174_22975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6174_22980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6174_22985	COG0237	dephospho-CoA kinase activity
L6174_22990	COG1971	Probably functions as a manganese efflux pump
L6174_23000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6174_23000	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6174_23005	COG5002	protein histidine kinase activity
L6174_23010	COG0745	RESPONSE REGULATOR receiver
L6174_23030	COG0538	isocitrate dehydrogenase activity
L6174_23035	COG0372	Belongs to the citrate synthase family
L6174_23045	COG0628	permease
L6174_23050	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6174_23075	COG1725	Transcriptional regulator
L6174_23080	COG0281	malic enzyme
L6174_23085	COG0587	DNA-directed DNA polymerase activity
L6174_23100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6174_23120	COG4109	DRTGG domain
L6174_23135	COG0006	proline dipeptidase activity
L6174_23175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_23180	COG0662	Cupin 2, conserved barrel domain protein
L6174_23190	COG1476	TRANSCRIPTIONal
L6174_23205	COG1028	Short-chain dehydrogenase reductase Sdr
L6174_23210	COG0589	response to stress
L6174_23250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_23270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6174_23275	COG0827	DNA restriction-modification system
L6174_23280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6174_23285	COG3874	Sporulation protein YtfJ
L6174_23300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6174_23310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6174_23325	COG1104	cysteine desulfurase activity
L6174_23335	COG0583	DNA-binding transcription factor activity
L6174_23340	COG0697	spore germination
L6174_23350	COG1956	GAF domain-containing protein
L6174_23355	COG0626	cystathionine gamma-synthase activity
L6174_23385	COG1595	DNA-templated transcription, initiation
L6174_23395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6174_23400	COG0454	-acetyltransferase
L6174_23405	COG0517	IMP dehydrogenase activity
L6174_23410	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6174_23420	COG0745	RESPONSE REGULATOR receiver
L6174_23430	COG0666	response to abiotic stimulus
L6174_23465	COG1609	Transcriptional regulator
L6174_23470	COG4851	CamS sex pheromone cAM373 precursor
L6174_23475	COG3118	belongs to the thioredoxin family
L6174_23485	COG2309	aminopeptidase activity
L6174_23505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_23520	COG1674	ftsk spoiiie
L6174_23530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6174_23535	COG4848	Belongs to the UPF0354 family
L6174_23540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6174_23545	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6174_23550	COG1363	Peptidase, m42
L6174_23560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_23575	COG0510	thiamine kinase activity
L6174_23580	COG1523	belongs to the glycosyl hydrolase 13 family
L6174_23595	COG1349	DNA-binding transcription factor activity
L6174_23600	COG1187	pseudouridine synthase activity
L6174_23605	COG2244	polysaccharide biosynthetic process
L6174_23610	COG2081	HI0933 family
L6174_23615	COG2814	Major facilitator Superfamily
L6174_23625	COG3832	glyoxalase III activity
L6174_23645	COG1329	Transcriptional regulator
L6174_23655	COG4975	Glucose uptake
L6174_23670	COG0314	molybdopterin synthase activity
L6174_23675	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6174_23680	COG0303	'Molybdopterin
L6174_23690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6174_23715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6174_23725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6174_23765	COG2814	Major facilitator Superfamily
L6174_23770	COG0475	glutathione-regulated potassium exporter activity
L6174_23775	COG0490	domain, Protein
L6174_23780	COG0582	viral genome integration into host DNA
L6174_23790	COG1136	(ABC) transporter
L6174_23810	COG1242	4 iron, 4 sulfur cluster binding
L6174_23815	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6174_23820	COG1131	(ABC) transporter
L6174_23830	COG1794	racemase activity, acting on amino acids and derivatives
L6174_23850	COG2267	carboxylic ester hydrolase activity
L6174_23855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6174_23860	COG0671	phosphoesterase, PA-phosphatase related
L6174_23865	COG0438	transferase activity, transferring glycosyl groups
L6174_23875	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6174_23930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6174_23935	COG5002	protein histidine kinase activity
L6174_23940	COG4191	Histidine kinase
L6174_23945	COG2267	carboxylic ester hydrolase activity
L6174_23965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6174_23970	COG1116	anion transmembrane transporter activity
L6174_23975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6174_24000	COG0494	nUDIX hydrolase
L6174_24035	COG0288	reversible hydration of carbon dioxide
L6174_24040	COG1271	oxidase subunit
L6174_24045	COG1294	oxidase, subunit
L6174_24065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_24090	COG1842	Phage shock protein A
L6174_24120	COG5002	protein histidine kinase activity
L6174_24125	COG0745	RESPONSE REGULATOR receiver
L6174_24155	COG1597	lipid kinase activity
L6174_24190	COG0586	Pfam SNARE associated Golgi protein
L6174_24200	COG0577	efflux transmembrane transporter activity
L6174_24205	COG1136	(ABC) transporter
L6174_24210	COG2207	Transcriptional regulator
L6174_24210	COG3708	Transcriptional regulator
L6174_24215	COG0745	RESPONSE REGULATOR receiver
L6174_24220	COG2205	protein histidine kinase activity
L6174_24230	COG0577	efflux transmembrane transporter activity
L6174_24235	COG1136	(ABC) transporter
L6174_24255	COG2188	Transcriptional regulator
L6174_24275	COG3964	amidohydrolase
L6174_24305	COG4948	Mandelate Racemase Muconate Lactonizing
L6174_24315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6174_24320	COG0596	Alpha beta hydrolase
L6174_24325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6174_24330	COG1169	isochorismate synthase
L6174_24335	COG1575	Belongs to the MenA family. Type 1 subfamily
L6174_24340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6174_24360	COG0058	SHG alpha-glucan phosphorylase activity
L6174_24365	COG0297	glycogen (starch) synthase activity
L6174_24370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6174_24485	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6174_24520	COG1285	pathogenesis
L6174_24525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6174_24535	COG0166	Belongs to the GPI family
L6174_24540	COG2155	Conserved Protein
L6174_24545	COG1098	S1 RNA binding domain
L6174_24550	COG0436	Aminotransferase
L6174_24555	COG1522	sequence-specific DNA binding
L6174_24560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6174_24565	COG2267	carboxylic ester hydrolase activity
L6174_24575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6174_24595	COG5018	Exonuclease
L6174_24600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6174_24620	COG2050	protein possibly involved in aromatic compounds catabolism
L6174_24630	COG1268	BioY protein
L6174_24640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6174_24645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6174_24660	COG3584	3D domain protein
L6174_24675	COG1252	NADH dehydrogenase
L6174_24690	COG3708	Transcriptional regulator
L6174_24705	COG1683	Conserved Protein
L6174_24725	COG0316	Belongs to the HesB IscA family
L6174_24740	COG1252	NADH dehydrogenase
L6174_24755	COG0390	transport system, permease component
L6174_24760	COG2824	Alkylphosphonate utilization operon protein PhnA
L6174_24800	COG4837	Protein of unknown function (DUF1462)
L6174_24805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6174_24815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6174_24820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6174_24830	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6174_24835	COG0647	UMP catabolic process
L6174_24845	COG2445	Protein of unknown function DUF86
L6174_24850	COG1494	fructose-1,6-bisphosphatase
L6174_24865	COG4470	Protein conserved in bacteria
L6174_24875	COG0789	Transcriptional regulator
L6174_24880	COG4377	Putative membrane peptidase family (DUF2324)
L6174_24905	COG0739	heme binding
L6174_24915	COG3377	Domain of unknown function (DUF1805)
L6174_24920	COG0737	Belongs to the 5'-nucleotidase family
L6174_24925	COG1695	Transcriptional regulator
L6174_24935	COG0719	Fe-S assembly protein
L6174_24940	COG0822	iron-sulfur transferase activity
L6174_24945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6174_24950	COG0719	Fe-S assembly protein
L6174_24955	COG0396	ATPase activity
L6174_24960	COG1464	Belongs to the NlpA lipoprotein family
L6174_24965	COG1464	Belongs to the NlpA lipoprotein family
L6174_24970	COG2011	ABC-type metal ion transport system permease component
L6174_24975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6174_24985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6174_24990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6174_25000	COG1393	Belongs to the ArsC family
L6174_25045	COG0039	L-malate dehydrogenase activity
L6174_25070	COG1309	transcriptional regulator
L6174_25075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6174_25080	COG1960	acyl-CoA dehydrogenase activity
L6174_25085	COG0183	Belongs to the thiolase family
L6174_25090	COG1024	Enoyl-CoA hydratase
L6174_25090	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6174_25100	COG1686	Belongs to the peptidase S11 family
L6174_25115	COG0011	TIGRFAM Protein of
L6174_25120	COG0840	transmembrane signaling receptor activity
L6174_25140	COG2814	Major facilitator Superfamily
L6174_25145	COG0531	amino acid
L6174_25155	COG0706	membrane insertase activity
L6174_25165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6174_25200	COG0586	Pfam SNARE associated Golgi protein
L6174_25210	COG1376	ErfK ybiS ycfS ynhG family protein
L6174_25215	COG0745	RESPONSE REGULATOR receiver
L6174_25245	COG2151	metal-sulfur cluster biosynthetic enzyme
L6174_25250	COG3227	Zinc metalloprotease (Elastase)
L6174_25255	COG1741	Belongs to the pirin family
L6174_25270	COG0475	glutathione-regulated potassium exporter activity
L6174_25275	COG0490	domain, Protein
L6174_25280	COG1115	amino acid carrier protein
L6174_25285	COG0783	Belongs to the Dps family
L6174_25300	COG1611	Belongs to the LOG family
L6174_25320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_25325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_25330	COG1115	amino acid carrier protein
L6174_25335	COG1115	amino acid carrier protein
L6174_25340	COG2910	NAD(P)H-binding
L6174_25355	COG0656	L-ascorbic acid biosynthetic process
L6174_25360	COG2814	Major facilitator Superfamily
L6174_25365	COG1733	regulation of RNA biosynthetic process
L6174_25375	COG1252	NADH dehydrogenase
L6174_25380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6174_25385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6174_25395	COG3290	protein histidine kinase activity
L6174_25395	COG0840	transmembrane signaling receptor activity
L6174_25405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6174_25410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6174_25425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6174_25480	COG0557	exoribonuclease II activity
L6174_25485	COG1647	Serine aminopeptidase, S33
L6174_25490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6174_25495	COG1346	cytolysis
L6174_25590	COG4695	Portal protein
L6174_25615	COG4974	Belongs to the 'phage' integrase family
L6174_25625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6174_25630	COG0149	triose-phosphate isomerase activity
L6174_25640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6174_25655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6174_25680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6174_25695	COG2323	membrane
L6174_25700	COG0740	serine-type endopeptidase activity
L6174_25705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6174_25715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6174_25725	COG1051	belongs to the nudix hydrolase family
L6174_25735	COG0492	ferredoxin-NADP+ reductase activity
L6174_25740	COG0457	Tetratricopeptide repeat
L6174_25745	COG0110	maltose O-acetyltransferase activity
L6174_25765	COG1950	PFAM Membrane protein of
L6174_25775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6174_25780	COG0556	nucleotide-excision repair
L6174_25800	COG0789	Transcriptional regulator
L6174_25825	COG2855	membrane
L6174_25830	COG0583	DNA-binding transcription factor activity
L6174_25840	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6174_25845	COG0488	(ABC) transporter
L6174_25855	COG1132	(ABC) transporter
L6174_25860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6174_25865	COG0793	Belongs to the peptidase S41A family
L6174_25865	COG3409	Peptidoglycan-binding domain 1 protein
L6174_25870	COG2177	Part of the ABC transporter FtsEX involved in
L6174_25875	COG2884	Cell division ATP-binding protein ftsE
L6174_25890	COG0653	protein targeting
L6174_25895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6174_25900	COG1278	Cold shock
L6174_25905	COG1040	competence protein
L6174_25910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6174_25915	COG1388	LysM domain
L6174_25915	COG0791	NLP P60 protein
L6174_25920	COG1733	regulation of RNA biosynthetic process
L6174_25925	COG1307	EDD domain protein, DegV family
L6174_25930	COG1739	Uncharacterized protein family UPF0029
L6174_25935	COG1316	TRANSCRIPTIONal
L6174_25940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6174_25945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6174_25950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6174_25960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6174_25960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6174_25975	COG3394	polysaccharide catabolic process
L6174_25980	COG1486	melibiose metabolic process
L6174_25985	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6174_25990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6174_26000	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6174_26005	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6174_26010	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6174_26020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6174_26025	COG1301	dicarboxylic acid transport
L6174_26035	COG0346	lactoylglutathione lyase activity
L6174_26040	COG1511	domain protein
L6174_26045	COG0583	DNA-binding transcription factor activity
L6174_26050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6174_26065	COG1271	oxidase subunit
L6174_26070	COG1294	oxidase, subunit
L6174_26075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6174_26085	COG1620	l-lactate permease
L6174_26095	COG2389	metal-binding protein
L6174_26105	COG1368	sulfuric ester hydrolase activity
L6174_26120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6174_26130	COG1215	transferase activity, transferring glycosyl groups
L6174_26135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6174_26140	COG1388	LysM domain
L6174_26140	COG3584	3D domain protein
L6174_26165	COG4715	Zinc finger, swim domain protein
L6174_26170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6174_26210	COG0577	efflux transmembrane transporter activity
L6174_26215	COG1136	(ABC) transporter
L6174_26250	COG5002	protein histidine kinase activity
L6174_26255	COG0745	RESPONSE REGULATOR receiver
L6174_26260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6174_26280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6174_26285	COG1134	teichoic acid transport
L6174_26290	COG1682	transport, permease protein
L6174_26295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L6174_26340	COG1609	Transcriptional regulator
L6174_26355	COG0739	heme binding
L6174_26375	COG2385	sporulation resulting in formation of a cellular spore
L6174_26390	COG4836	Membrane
L6174_26395	COG1007	ATP synthesis coupled electron transport
L6174_26400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6174_26405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6174_26415	COG0839	Belongs to the complex I subunit 6 family
L6174_26430	COG0649	NAD binding
L6174_26435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6174_26450	COG3300	MHYT domain
L6174_26450	COG5001	Diguanylate cyclase
L6174_26500	COG0356	it plays a direct role in the translocation of protons across the membrane
L6174_26535	COG0698	ribose 5-phosphate isomerase
L6174_26545	COG2190	(PTS) system
L6174_26550	COG2259	Doxx family
L6174_26555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6174_26570	COG0009	L-threonylcarbamoyladenylate synthase
L6174_26585	COG2890	protein-(glutamine-N5) methyltransferase activity
L6174_26605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6174_26610	COG1494	fructose-1,6-bisphosphatase
L6174_26630	COG4821	SIS domain
L6174_26640	COG3343	RNA polymerase activity
L6174_26650	COG1960	acyl-CoA dehydrogenase activity
L6174_26655	COG1960	acyl-CoA dehydrogenase activity
L6174_26660	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6174_26665	COG0183	Belongs to the thiolase family
L6174_26670	COG0247	lactate metabolic process
L6174_26670	COG2181	nitrate reductase activity
L6174_26675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6174_26685	COG5001	Diguanylate cyclase
L6174_26685	COG3300	MHYT domain
L6174_26705	COG2197	response regulator
L6174_26710	COG4585	Histidine kinase
L6174_26715	COG0842	Transport permease protein
L6174_26720	COG1131	(ABC) transporter
L6174_26725	COG0024	Methionine aminopeptidase
L6174_26735	COG2234	aminopeptidase activity
L6174_26755	COG1595	DNA-templated transcription, initiation
L6174_26760	COG0018	arginyl-trna synthetase
L6174_26765	COG4506	Protein conserved in bacteria
L6174_26770	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6174_26785	COG0010	Belongs to the arginase family
L6174_26795	COG2814	Major facilitator Superfamily
L6174_26800	COG0789	Transcriptional regulator
L6174_26805	COG0584	glycerophosphoryl diester phosphodiesterase
L6174_26810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6174_26820	COG1994	Peptidase M50
L6174_26830	COG1078	dGTPase activity
L6174_26835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6174_26840	COG1120	ATPase activity
L6174_26845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6174_26870	COG0095	Lipoate-protein ligase
L6174_26875	COG0280	phosphate acetyltransferase
L6174_26890	COG3773	Cell wall hydrolase
L6174_26900	COG2363	Small membrane protein
L6174_26910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6174_26915	COG2233	PERMEase
L6174_26920	COG0561	phosphatase activity
L6174_26925	COG2814	Major facilitator Superfamily
L6174_26935	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6174_26940	COG1131	(ABC) transporter
L6174_26945	COG2755	lipolytic protein G-D-S-L family
L6174_26950	COG1609	Transcriptional regulator
L6174_26960	COG0460	homoserine dehydrogenase
L6174_26970	COG2873	o-acetylhomoserine
L6174_26980	COG1011	Hydrolase
L6174_26985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6174_26995	COG2197	response regulator
L6174_27005	COG0351	phosphomethylpyrimidine kinase
L6174_27010	COG3706	GGDEF domain
L6174_27015	COG2879	small protein
L6174_27020	COG1966	Carbon starvation protein
L6174_27025	COG3279	Response regulator of the LytR AlgR family
L6174_27030	COG0477	Major facilitator Superfamily
L6174_27055	COG0840	transmembrane signaling receptor activity
L6174_27065	COG1607	acyl-coa hydrolase
L6174_27080	COG0488	(ABC) transporter
L6174_27100	COG0463	Glycosyl transferase, family 2
L6174_27105	COG1309	transcriptional regulator
L6174_27110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6174_27115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6174_27115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6174_27120	COG0628	permease
L6174_27135	COG3279	Response regulator of the LytR AlgR family
L6174_27140	COG3275	phosphorelay sensor kinase activity
L6174_27145	COG2814	Major facilitator Superfamily
L6174_27150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6174_27155	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6174_27160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6174_27180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6174_27185	COG1272	protein, Hemolysin III
L6174_27205	COG0516	GMP reductase activity
L6174_27210	COG1164	Oligoendopeptidase f
L6174_27230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6174_27235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6174_27240	COG4853	Protein conserved in bacteria
L6174_27245	COG4863	YycH protein
L6174_27250	COG5002	protein histidine kinase activity
L6174_27255	COG0745	RESPONSE REGULATOR receiver
L6174_27285	COG0305	Participates in initiation and elongation during chromosome replication
L6174_27295	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6174_27300	COG4241	membrane
L6174_27310	COG0629	single-stranded DNA binding
L6174_27320	COG0012	GTP binding
L6174_27325	COG4481	Protein conserved in bacteria
L6174_27330	COG0668	transmembrane transport
L6174_27340	COG1475	DNA binding
L6174_27345	COG1192	Involved in chromosome partitioning
L6174_27370	COG1847	R3H domain protein
L6174_27375	COG0706	membrane insertase activity
L6174_27385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6174_27440	COG3344	reverse transcriptase
L6174_27520	COG3344	reverse transcriptase
L6174_27725	COG4962	Type ii secretion system protein e
L6174_27860	COG2311	Membrane
L6174_27880	COG4196	transglutaminase domain protein
L6174_27890	COG0671	phosphoesterase, PA-phosphatase related
L6174_27905	COG1215	transferase activity, transferring glycosyl groups
L6174_27910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6174_27915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6174_28085	COG2002	toxin-antitoxin pair type II binding
L6174_28095	COG4974	Belongs to the 'phage' integrase family
L6174_28150	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6174_28160	COG4974	Belongs to the 'phage' integrase family
L6174_28185	COG0457	Tetratricopeptide repeat
L6174_28270	COG0791	NLP P60 protein
L6174_28270	COG0741	lytic transglycosylase activity
L6174_28425	COG1192	Involved in chromosome partitioning
L6174_28470	COG1683	Conserved Protein
L6174_28475	COG1309	transcriptional regulator
L6174_28550	COG0681	Belongs to the peptidase S26 family
L6174_28575	COG1280	lysine exporter protein (LysE YggA)
L6174_28620	COG4166	transmembrane transport
L6174_28630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII