locus-tag	class	description
L6176_00010	COG0592	DNA-directed DNA polymerase activity
L6176_00015	COG2501	S4 domain
L6176_00025	COG0187	DNA topoisomerase II activity
L6176_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6176_00065	COG0516	GMP reductase activity
L6176_00065	COG0517	IMP dehydrogenase activity
L6176_00070	COG1686	Belongs to the peptidase S11 family
L6176_00100	COG1428	Deoxynucleoside kinase
L6176_00105	COG1428	Deoxynucleoside kinase
L6176_00110	COG1335	isochorismatase
L6176_00115	COG0590	tRNA wobble adenosine to inosine editing
L6176_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L6176_00180	COG1982	Orn Lys Arg decarboxylase major
L6176_00190	COG0470	DNA polymerase III
L6176_00195	COG1774	PSP1 C-terminal conserved region
L6176_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L6176_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L6176_00220	COG2002	toxin-antitoxin pair type II binding
L6176_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6176_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6176_00230	COG0084	hydrolase, TatD family'
L6176_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6176_00250	COG4466	Protein conserved in bacteria
L6176_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L6176_00270	COG0251	oxidation-reduction process
L6176_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L6176_00305	COG2002	toxin-antitoxin pair type II binding
L6176_00310	COG2244	polysaccharide biosynthetic process
L6176_00315	COG3956	TIGRFAM MazG family protein
L6176_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L6176_00340	COG1098	S1 RNA binding domain
L6176_00355	COG2208	phosphoserine phosphatase activity
L6176_00360	COG0037	tRNA processing
L6176_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L6176_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L6176_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6176_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L6176_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
L6176_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6176_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L6176_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L6176_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L6176_00420	COG1396	sequence-specific DNA binding
L6176_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6176_00455	COG3880	PFAM UvrB UvrC protein
L6176_00465	COG0542	response to heat
L6176_00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L6176_00480	COG4956	integral membrane protein (PIN domain superfamily)
L6176_00500	COG1045	serine acetyltransferase
L6176_00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6176_00520	COG3688	RNA-binding protein containing a PIN domain
L6176_00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6176_00540	COG0250	Participates in transcription elongation, termination and antitermination
L6176_00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L6176_00565	COG2813	Specifically methylates the guanine in position
L6176_00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L6176_00580	COG1358	cellular component organization or biogenesis
L6176_00650	COG0255	Belongs to the universal ribosomal protein uL29 family
L6176_00710	COG0201	protein transport
L6176_00720	COG0024	Methionine aminopeptidase
L6176_00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L6176_00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6176_00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6176_00795	COG0489	protein tyrosine kinase activity
L6176_00805	COG2194	sulfuric ester hydrolase activity
L6176_00810	COG0726	polysaccharide deacetylase
L6176_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L6176_00895	COG4856	YbbR-like protein
L6176_00910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L6176_00915	COG0596	Alpha beta hydrolase
L6176_00935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L6176_00940	COG1506	peptidase
L6176_00940	COG0823	Involved in the tonB-independent uptake of proteins
L6176_00940	COG4946	Tricorn protease homolog
L6176_00975	COG2011	ABC-type metal ion transport system permease component
L6176_00980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6176_00985	COG1464	Belongs to the NlpA lipoprotein family
L6176_00990	COG0604	alcohol dehydrogenase
L6176_01000	COG0277	FAD linked oxidase domain protein
L6176_01005	COG2271	Major facilitator Superfamily
L6176_01015	COG2814	Major facilitator Superfamily
L6176_01030	COG0601	transmembrane transport
L6176_01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6176_01040	COG0444	Belongs to the ABC transporter superfamily
L6176_01045	COG4608	Belongs to the ABC transporter superfamily
L6176_01050	COG4166	transmembrane transport
L6176_01060	COG2207	Transcriptional regulator
L6176_01075	COG4166	transmembrane transport
L6176_01080	COG4166	transmembrane transport
L6176_01085	COG0656	L-ascorbic acid biosynthetic process
L6176_01105	COG4149	molybdate abc transporter
L6176_01115	COG1910	domain protein
L6176_01125	COG0583	DNA-binding transcription factor activity
L6176_01130	COG0697	spore germination
L6176_01145	COG0204	Acyl-transferase
L6176_01155	COG1609	Transcriptional regulator
L6176_01165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_01175	COG0084	hydrolase, TatD family'
L6176_01180	COG5298	Protein conserved in bacteria
L6176_01205	COG0488	(ABC) transporter
L6176_01220	COG0747	negative chemotaxis
L6176_01225	COG0601	transmembrane transport
L6176_01230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6176_01235	COG0444	Belongs to the ABC transporter superfamily
L6176_01240	COG4608	Belongs to the ABC transporter superfamily
L6176_01275	COG3185	4-Hydroxyphenylpyruvate dioxygenase
L6176_01280	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6176_01290	COG2814	Major facilitator Superfamily
L6176_01300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L6176_01310	COG4294	response to UV
L6176_01315	COG0457	Tetratricopeptide repeat
L6176_01315	COG0705	Rhomboid family
L6176_01325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L6176_01330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6176_01335	COG0864	Transcriptional regulator
L6176_01340	COG2337	Toxic component of a toxin-antitoxin (TA) module
L6176_01345	COG2183	response to ionizing radiation
L6176_01440	COG0802	atpase or kinase
L6176_01445	COG1214	PFAM Peptidase M22, glycoprotease
L6176_01450	COG0456	acetyltransferase
L6176_01460	COG0488	(ABC) transporter
L6176_01475	COG1266	CAAX protease self-immunity
L6176_01495	COG2252	PERMEase
L6176_01535	COG2226	methyltransferase
L6176_01580	COG1968	undecaprenyl-diphosphatase activity
L6176_01595	COG2205	protein histidine kinase activity
L6176_01600	COG0745	RESPONSE REGULATOR receiver
L6176_01625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L6176_01630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L6176_01635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L6176_01645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L6176_01660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L6176_01670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L6176_01680	COG0151	Belongs to the GarS family
L6176_01705	COG0210	DNA helicase
L6176_01715	COG4851	CamS sex pheromone cAM373 precursor
L6176_01735	COG1335	isochorismatase
L6176_01740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6176_01745	COG2011	ABC-type metal ion transport system permease component
L6176_01750	COG1464	Belongs to the NlpA lipoprotein family
L6176_01775	COG1846	Transcriptional regulator
L6176_01800	COG1597	lipid kinase activity
L6176_01805	COG0546	phosphoglycolate phosphatase activity
L6176_01810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6176_01820	COG1012	belongs to the aldehyde dehydrogenase family
L6176_01825	COG2076	Multidrug Resistance protein
L6176_01830	COG2309	aminopeptidase activity
L6176_01845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_01850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6176_01855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L6176_01865	COG4807	Protein conserved in bacteria
L6176_01890	COG1757	Na H antiporter
L6176_01895	COG1473	amidohydrolase
L6176_01910	COG0450	alkyl hydroperoxide reductase
L6176_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_01935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_01940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_01955	COG0166	Belongs to the GPI family
L6176_01990	COG5002	protein histidine kinase activity
L6176_02010	COG3541	Predicted nucleotidyltransferase
L6176_02015	COG2814	Major facilitator Superfamily
L6176_02020	COG0723	plastoquinol--plastocyanin reductase activity
L6176_02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6176_02030	COG0765	amino acid transport
L6176_02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6176_02045	COG0840	transmembrane signaling receptor activity
L6176_02050	COG0840	transmembrane signaling receptor activity
L6176_02055	COG0366	Alpha amylase catalytic
L6176_02060	COG2190	(PTS) system
L6176_02060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_02060	COG1263	PTS System
L6176_02090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
L6176_02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6176_02115	COG1116	anion transmembrane transporter activity
L6176_02120	COG0488	(ABC) transporter
L6176_02165	COG2270	Major facilitator Superfamily
L6176_02180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6176_02195	COG2310	stress, protein
L6176_02200	COG2310	stress, protein
L6176_02205	COG2310	stress, protein
L6176_02210	COG0861	Integral membrane protein TerC family
L6176_02220	COG3853	Toxic anion resistance protein (TelA)
L6176_02235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L6176_02245	COG1295	ribonuclease BN
L6176_02250	COG2217	Heavy metal translocating P-type atpase
L6176_02255	COG0697	spore germination
L6176_02275	COG0586	Pfam SNARE associated Golgi protein
L6176_02290	COG3871	stress protein (general stress protein 26)
L6176_02295	COG0387	Pfam Sodium calcium exchanger
L6176_02305	COG0535	radical SAM domain protein
L6176_02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L6176_02335	COG0582	viral genome integration into host DNA
L6176_02345	COG1396	sequence-specific DNA binding
L6176_02360	COG1396	sequence-specific DNA binding
L6176_02395	COG1484	DNA-dependent DNA replication
L6176_02625	COG0101	tRNA pseudouridine synthase activity
L6176_02635	COG3829	transcription factor binding
L6176_02645	COG0833	amino acid
L6176_02650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6176_02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_02680	COG1263	PTS System
L6176_02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6176_02700	COG0463	Glycosyl transferase, family 2
L6176_02710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L6176_02710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6176_02725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L6176_02745	COG1228	amidohydrolase
L6176_02750	COG1090	epimerase
L6176_02780	COG1988	membrane-bound metal-dependent
L6176_02785	COG1194	a g-specific adenine glycosylase
L6176_02810	COG1132	(ABC) transporter
L6176_02815	COG4129	membrane
L6176_02820	COG0067	glutamate synthase
L6176_02820	COG0070	glutamate synthase
L6176_02820	COG0069	glutamate synthase activity
L6176_02830	COG4555	ABC transporter
L6176_02850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L6176_02855	COG0735	belongs to the Fur family
L6176_02970	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
L6176_02975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L6176_02985	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L6176_02995	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L6176_03005	COG2766	serine protein kinase
L6176_03025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6176_03035	COG1585	Membrane protein implicated in regulation of membrane protease activity
L6176_03040	COG2268	Band 7 protein
L6176_03050	COG3290	protein histidine kinase activity
L6176_03055	COG4565	transcriptional regulatory protein
L6176_03060	COG2851	Citrate transporter
L6176_03080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6176_03085	COG3842	ATPase activity
L6176_03090	COG1175	transmembrane transport
L6176_03095	COG0395	ABC-type sugar transport system, permease component
L6176_03105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L6176_03110	COG0745	RESPONSE REGULATOR receiver
L6176_03115	COG5002	protein histidine kinase activity
L6176_03125	COG4990	cell redox homeostasis
L6176_03135	COG3290	protein histidine kinase activity
L6176_03140	COG4565	transcriptional regulatory protein
L6176_03145	COG3493	citrate carrier protein
L6176_03150	COG0281	malic enzyme
L6176_03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_03175	COG5002	protein histidine kinase activity
L6176_03180	COG0745	RESPONSE REGULATOR receiver
L6176_03185	COG0454	-acetyltransferase
L6176_03185	COG0456	acetyltransferase
L6176_03190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6176_03195	COG3383	formate dehydrogenase (NAD+) activity
L6176_03215	COG0531	amino acid
L6176_03220	COG0640	Transcriptional regulator
L6176_03225	COG2217	Heavy metal translocating P-type atpase
L6176_03230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L6176_03245	COG3227	Zinc metalloprotease (Elastase)
L6176_03265	COG2720	vancomycin resistance protein
L6176_03270	COG1316	TRANSCRIPTIONal
L6176_03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_03280	COG0346	lactoylglutathione lyase activity
L6176_03290	COG1027	Aspartate ammonia-lyase
L6176_03295	COG1620	l-lactate permease
L6176_03310	COG3104	oligopeptide transport
L6176_03315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_03335	COG2226	methyltransferase
L6176_03340	COG0156	8-amino-7-oxononanoate synthase activity
L6176_03360	COG0714	Associated with various cellular activities
L6176_03365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6176_03385	COG0531	amino acid
L6176_03390	COG2188	Transcriptional regulator
L6176_03395	COG1263	PTS System
L6176_03395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_03400	COG0366	Alpha amylase catalytic
L6176_03415	COG0697	spore germination
L6176_03425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6176_03430	COG1115	amino acid carrier protein
L6176_03435	COG1126	abc transporter atp-binding protein
L6176_03440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6176_03445	COG0765	amino acid transport
L6176_03450	COG0765	amino acid transport
L6176_03455	COG0833	amino acid
L6176_03480	COG2378	regulation of single-species biofilm formation
L6176_03485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L6176_03490	COG5002	protein histidine kinase activity
L6176_03505	COG0659	secondary active sulfate transmembrane transporter activity
L6176_03520	COG0747	negative chemotaxis
L6176_03530	COG0601	transmembrane transport
L6176_03535	COG4608	Belongs to the ABC transporter superfamily
L6176_03545	COG2271	Major facilitator Superfamily
L6176_03550	COG1846	Transcriptional regulator
L6176_03560	COG1609	Transcriptional regulator
L6176_03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6176_03580	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6176_03585	COG1879	ABC-type sugar transport system periplasmic component
L6176_03610	COG1063	alcohol dehydrogenase
L6176_03625	COG3568	Endonuclease Exonuclease Phosphatase
L6176_03650	COG1968	undecaprenyl-diphosphatase activity
L6176_03655	COG0840	transmembrane signaling receptor activity
L6176_03665	COG1476	TRANSCRIPTIONal
L6176_03680	COG3104	oligopeptide transport
L6176_03685	COG1114	Component of the transport system for branched-chain amino acids
L6176_03700	COG1113	amino acid transport
L6176_03705	COG2252	PERMEase
L6176_03730	COG0569	domain protein
L6176_03730	COG0475	glutathione-regulated potassium exporter activity
L6176_03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L6176_03750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L6176_03755	COG4990	cell redox homeostasis
L6176_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6176_03775	COG0697	spore germination
L6176_03780	COG0531	amino acid
L6176_03790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6176_03795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6176_03800	COG1918	ferrous iron import across plasma membrane
L6176_03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L6176_03805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6176_03810	COG0573	inorganic phosphate transmembrane transporter activity
L6176_03815	COG0581	inorganic phosphate transmembrane transporter activity
L6176_03945	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L6176_03965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6176_03970	COG1116	anion transmembrane transporter activity
L6176_03975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6176_03980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6176_03985	COG0352	thiamine-phosphate diphosphorylase activity
L6176_03990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6176_03995	COG2104	thiamine diphosphate biosynthetic process
L6176_04005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6176_04010	COG0351	phosphomethylpyrimidine kinase
L6176_04050	COG2205	protein histidine kinase activity
L6176_04055	COG2814	Major facilitator Superfamily
L6176_04060	COG1846	Transcriptional regulator
L6176_04075	COG2252	PERMEase
L6176_04080	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L6176_04100	COG1621	beta-fructofuranosidase activity
L6176_04105	COG1263	PTS System
L6176_04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_04110	COG1609	Transcriptional regulator
L6176_04120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6176_04125	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L6176_04160	COG0778	Nitroreductase
L6176_04165	COG2719	SpoVR family
L6176_04190	COG0446	pyridine nucleotide-disulphide oxidoreductase
L6176_04195	COG1937	Protein conserved in bacteria
L6176_04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6176_04200	COG0425	Belongs to the sulfur carrier protein TusA family
L6176_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6176_04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_04210	COG0425	Belongs to the sulfur carrier protein TusA family
L6176_04225	COG2210	Belongs to the sulfur carrier protein TusA family
L6176_04230	COG0730	response to heat
L6176_04240	COG1316	TRANSCRIPTIONal
L6176_04245	COG0604	alcohol dehydrogenase
L6176_04250	COG1283	sodium-dependent phosphate transmembrane transporter activity
L6176_04265	COG3711	transcriptional antiterminator
L6176_04265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6176_04270	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6176_04275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6176_04295	COG1388	LysM domain
L6176_04295	COG3584	3D domain protein
L6176_04300	COG0577	efflux transmembrane transporter activity
L6176_04305	COG1136	(ABC) transporter
L6176_04315	COG5522	Integral membrane protein (intg_mem_TP0381)
L6176_04330	COG1114	Component of the transport system for branched-chain amino acids
L6176_04335	COG3546	catalase activity
L6176_04370	COG0586	Pfam SNARE associated Golgi protein
L6176_04405	COG0531	amino acid
L6176_04410	COG0475	glutathione-regulated potassium exporter activity
L6176_04420	COG1737	Transcriptional regulator
L6176_04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_04430	COG1263	PTS System
L6176_04440	COG2259	Doxx family
L6176_04455	COG0697	spore germination
L6176_04460	COG1522	sequence-specific DNA binding
L6176_04475	COG2076	Multidrug Resistance protein
L6176_04480	COG1309	transcriptional regulator
L6176_04485	COG2814	Major facilitator Superfamily
L6176_04490	COG1733	regulation of RNA biosynthetic process
L6176_04500	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6176_04505	COG4533	DNA binding
L6176_04510	COG2211	Major facilitator Superfamily
L6176_04520	COG0693	protein deglycase activity
L6176_04525	COG0753	catalase activity
L6176_04525	COG0693	protein deglycase activity
L6176_04535	COG0531	amino acid
L6176_04540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L6176_04550	COG1012	belongs to the aldehyde dehydrogenase family
L6176_04555	COG1132	(ABC) transporter
L6176_04565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6176_04570	COG0765	amino acid transport
L6176_04575	COG1126	abc transporter atp-binding protein
L6176_04590	COG0189	ligase activity
L6176_04620	COG0028	Belongs to the TPP enzyme family
L6176_04625	COG3527	Alpha-acetolactate decarboxylase
L6176_04640	COG0561	phosphatase activity
L6176_04655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6176_04670	COG0659	secondary active sulfate transmembrane transporter activity
L6176_04690	COG0653	protein targeting
L6176_04695	COG2244	polysaccharide biosynthetic process
L6176_04705	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6176_04710	COG4196	transglutaminase domain protein
L6176_04725	COG1696	Membrane protein involved in D-alanine export
L6176_04740	COG1024	Enoyl-CoA hydratase
L6176_04760	COG1363	Peptidase, m42
L6176_04780	COG3938	Belongs to the proline racemase family
L6176_04820	COG0601	transmembrane transport
L6176_04825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6176_04835	COG4608	Belongs to the ABC transporter superfamily
L6176_04870	COG0477	Major facilitator Superfamily
L6176_04875	COG3290	protein histidine kinase activity
L6176_04880	COG4565	transcriptional regulatory protein
L6176_04885	COG3181	Tripartite tricarboxylate transporter family receptor
L6176_04915	COG4978	Transcriptional regulator
L6176_04915	COG0789	Transcriptional regulator
L6176_04930	COG0305	Participates in initiation and elongation during chromosome replication
L6176_04970	COG0477	Major facilitator Superfamily
L6176_05015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6176_05015	COG3320	Male sterility
L6176_05020	COG1309	transcriptional regulator
L6176_05040	COG1183	phosphatidylcholine synthase activity
L6176_05060	COG2376	Dihydroxyacetone kinase
L6176_05070	COG2376	Dihydroxyacetone kinase
L6176_05075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6176_05080	COG1959	2 iron, 2 sulfur cluster binding
L6176_05110	COG2770	Histidine kinase
L6176_05110	COG3437	response regulator, receiver
L6176_05160	COG3237	CsbD-like
L6176_05185	COG1191	sigma factor activity
L6176_05195	COG2208	phosphoserine phosphatase activity
L6176_05200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6176_05205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6176_05205	COG2198	Histidine kinase
L6176_05205	COG0784	Response regulator, receiver
L6176_05205	COG2205	protein histidine kinase activity
L6176_05260	COG0420	3'-5' exonuclease activity
L6176_05285	COG1309	transcriptional regulator
L6176_05290	COG2814	Major facilitator Superfamily
L6176_05295	COG0346	lactoylglutathione lyase activity
L6176_05305	COG0457	Tetratricopeptide repeat
L6176_05310	COG2267	carboxylic ester hydrolase activity
L6176_05330	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L6176_05335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L6176_05345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L6176_05385	COG0477	Major facilitator Superfamily
L6176_05390	COG0477	Major facilitator Superfamily
L6176_05400	COG3973	AAA domain
L6176_05405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6176_05425	COG4980	gas vesicle protein
L6176_05430	COG0537	adenosine 5'-monophosphoramidase activity
L6176_05435	COG1131	(ABC) transporter
L6176_05440	COG4473	ABC transporter
L6176_05455	COG1309	transcriptional regulator
L6176_05465	COG3402	PFAM membrane-flanked domain
L6176_05510	COG3402	PFAM membrane-flanked domain
L6176_05515	COG3428	Bacterial PH domain
L6176_05520	COG2329	Antibiotic biosynthesis monooxygenase
L6176_05525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6176_05530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L6176_05535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6176_05540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6176_05575	COG1309	transcriptional regulator
L6176_05580	COG1511	domain protein
L6176_05605	COG1609	Transcriptional regulator
L6176_05615	COG1234	tRNA 3'-trailer cleavage
L6176_05620	COG0095	Lipoate-protein ligase
L6176_05630	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_05660	COG3209	COG3209 Rhs family protein
L6176_05700	COG1078	dGTPase activity
L6176_05710	COG1595	DNA-templated transcription, initiation
L6176_05715	COG3708	Transcriptional regulator
L6176_05715	COG2207	Transcriptional regulator
L6176_05730	COG2205	protein histidine kinase activity
L6176_05735	COG0745	RESPONSE REGULATOR receiver
L6176_05760	COG0501	Belongs to the peptidase M48B family
L6176_05765	COG0840	transmembrane signaling receptor activity
L6176_05770	COG0697	spore germination
L6176_05790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L6176_05795	COG2224	Isocitrate lyase
L6176_05820	COG4903	ComK protein
L6176_05825	COG0398	Pfam SNARE associated Golgi protein
L6176_05835	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L6176_05840	COG1074	ATP-dependent DNA helicase activity
L6176_05885	COG0179	Fumarylacetoacetate (FAA) hydrolase
L6176_05910	COG0367	asparagine synthase
L6176_05915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L6176_05920	COG0753	catalase activity
L6176_05925	COG0004	ammonium transporteR
L6176_05945	COG2996	Protein conserved in bacteria
L6176_05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6176_05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_05980	COG0561	phosphatase activity
L6176_05990	COG0542	response to heat
L6176_06000	COG2267	carboxylic ester hydrolase activity
L6176_06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L6176_06025	COG5504	Zn-dependent protease
L6176_06035	COG0180	Tryptophanyl-tRNA synthetase
L6176_06045	COG4166	transmembrane transport
L6176_06050	COG0601	transmembrane transport
L6176_06055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6176_06060	COG0444	Belongs to the ABC transporter superfamily
L6176_06065	COG4608	Belongs to the ABC transporter superfamily
L6176_06070	COG0534	Mate efflux family protein
L6176_06075	COG4166	transmembrane transport
L6176_06090	COG0861	Integral membrane protein TerC family
L6176_06095	COG4862	establishment of competence for transformation
L6176_06100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6176_06110	COG1164	Oligoendopeptidase f
L6176_06120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6176_06125	COG2346	COG2346, Truncated hemoglobins
L6176_06130	COG4116	CYTH
L6176_06140	COG2357	RelA SpoT domain protein
L6176_06150	COG0564	pseudouridine synthase activity
L6176_06170	COG0463	Glycosyl transferase, family 2
L6176_06170	COG1216	Glycosyl transferase, family 2
L6176_06190	COG0463	Glycosyl transferase, family 2
L6176_06190	COG0457	Tetratricopeptide repeat
L6176_06210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L6176_06225	COG1091	dTDP-4-dehydrorhamnose reductase activity
L6176_06270	COG2153	protein acetylation
L6176_06280	COG2382	esterase
L6176_06295	COG5492	domain, Protein
L6176_06300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6176_06310	COG0512	Glutamine amidotransferase of anthranilate synthase
L6176_06310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L6176_06345	COG1620	l-lactate permease
L6176_06350	COG5634	Uncharacterized conserved protein (DUF2278)
L6176_06405	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6176_06415	COG1476	TRANSCRIPTIONal
L6176_06475	COG2226	methyltransferase
L6176_06485	COG1686	Belongs to the peptidase S11 family
L6176_06490	COG0681	Belongs to the peptidase S26 family
L6176_06525	COG1012	belongs to the aldehyde dehydrogenase family
L6176_06530	COG3842	ATPase activity
L6176_06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
L6176_06540	COG1177	transmembrane transport
L6176_06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
L6176_06555	COG2409	Drug exporters of the RND superfamily
L6176_06565	COG0564	pseudouridine synthase activity
L6176_06575	COG2340	Cysteine-rich secretory protein family
L6176_06580	COG0247	lactate metabolic process
L6176_06585	COG0277	FAD linked oxidase domain protein
L6176_06590	COG3835	regulator
L6176_06600	COG0745	RESPONSE REGULATOR receiver
L6176_06605	COG5002	protein histidine kinase activity
L6176_06610	COG2186	Transcriptional regulator
L6176_06630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L6176_06640	COG2116	formate transmembrane transporter activity
L6176_06645	COG0861	Integral membrane protein TerC family
L6176_06650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6176_06660	COG2030	dehydratase
L6176_06680	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_06685	COG3243	poly(R)-hydroxyalkanoic acid synthase
L6176_06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6176_06695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6176_06710	COG1840	ABC-type Fe3 transport system, periplasmic component
L6176_06740	COG1349	DNA-binding transcription factor activity
L6176_06760	COG2861	carbohydrate metabolic process
L6176_06770	COG3852	Histidine kinase
L6176_06775	COG1846	Transcriptional regulator
L6176_06785	COG2318	DinB family
L6176_06795	COG5002	protein histidine kinase activity
L6176_06805	COG0720	synthase
L6176_06820	COG4873	Protein conserved in bacteria
L6176_06850	COG1780	Probably involved in ribonucleotide reductase function
L6176_06870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L6176_06875	COG1725	Transcriptional regulator
L6176_06880	COG1131	(ABC) transporter
L6176_06890	COG1131	(ABC) transporter
L6176_06895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6176_06910	COG1522	sequence-specific DNA binding
L6176_06920	COG1335	isochorismatase
L6176_06930	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6176_06935	COG2070	2-Nitropropane dioxygenase
L6176_06940	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6176_06950	COG1696	Membrane protein involved in D-alanine export
L6176_06975	COG0716	FMN binding
L6176_06990	COG3173	Aminoglycoside phosphotransferase
L6176_07010	COG0534	Mate efflux family protein
L6176_07015	COG1968	undecaprenyl-diphosphatase activity
L6176_07030	COG1846	Transcriptional regulator
L6176_07040	COG1301	dicarboxylic acid transport
L6176_07045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L6176_07050	COG4709	membrane
L6176_07055	COG3874	Sporulation protein YtfJ
L6176_07075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6176_07080	COG0028	Belongs to the TPP enzyme family
L6176_07085	COG0440	acetolactate synthase activity
L6176_07090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6176_07100	COG0473	3-isopropylmalate dehydrogenase activity
L6176_07125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L6176_07160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6176_07175	COG1183	phosphatidylcholine synthase activity
L6176_07180	COG1368	sulfuric ester hydrolase activity
L6176_07190	COG0019	diaminopimelate decarboxylase activity
L6176_07210	COG0529	Catalyzes the synthesis of activated sulfate
L6176_07215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6176_07235	COG1648	precorrin-2 dehydrogenase activity
L6176_07240	COG0733	neurotransmitter:sodium symporter activity
L6176_07260	COG1757	Na H antiporter
L6176_07275	COG4758	membrane
L6176_07280	COG4585	Histidine kinase
L6176_07285	COG2197	response regulator
L6176_07295	COG1114	Component of the transport system for branched-chain amino acids
L6176_07305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L6176_07330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L6176_07330	COG1017	nitric oxide dioxygenase activity
L6176_07345	COG0730	response to heat
L6176_07350	COG0306	phosphate transporter
L6176_07355	COG1392	Phosphate transport regulator
L6176_07360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6176_07375	COG3852	Histidine kinase
L6176_07380	COG1801	Protein of unknown function DUF72
L6176_07390	COG0582	viral genome integration into host DNA
L6176_07395	COG5002	protein histidine kinase activity
L6176_07415	COG0392	lysyltransferase activity
L6176_07415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L6176_07430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6176_07435	COG1686	Belongs to the peptidase S11 family
L6176_07440	COG2715	membrane protein required for spore maturation
L6176_07445	COG0700	Nucleoside recognition
L6176_07450	COG1187	pseudouridine synthase activity
L6176_07460	COG1333	cytochrome c biogenesis protein
L6176_07465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6176_07470	COG0745	RESPONSE REGULATOR receiver
L6176_07475	COG5002	protein histidine kinase activity
L6176_07480	COG2096	Adenosyltransferase
L6176_07495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L6176_07500	COG1141	Ferredoxin
L6176_07505	COG4955	Helix-turn-helix domain
L6176_07510	COG0514	ATP-dependent DNA helicase (RecQ)
L6176_07515	COG1266	CAAX protease self-immunity
L6176_07535	COG4862	establishment of competence for transformation
L6176_07540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L6176_07560	COG0492	ferredoxin-NADP+ reductase activity
L6176_07565	COG0252	asparaginase activity
L6176_07635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6176_07650	COG0142	geranyltranstransferase activity
L6176_07660	COG0142	geranyltranstransferase activity
L6176_07680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6176_07685	COG0457	Tetratricopeptide repeat
L6176_07705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L6176_07715	COG4347	Protein of unknown function (DUF1405)
L6176_07730	COG2738	Putative neutral zinc metallopeptidase
L6176_07740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_07745	COG1694	Mazg nucleotide pyrophosphohydrolase
L6176_07760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6176_07765	COG0438	transferase activity, transferring glycosyl groups
L6176_07800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L6176_07800	COG1199	ATP-dependent helicase activity
L6176_07820	COG3935	DnaD domain protein
L6176_07825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L6176_07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6176_07835	COG4499	WXG100 protein secretion system (Wss), protein YukC
L6176_07895	COG0116	Belongs to the methyltransferase superfamily
L6176_07905	COG1199	ATP-dependent helicase activity
L6176_07910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L6176_07920	COG3173	Aminoglycoside phosphotransferase
L6176_07925	COG0024	Methionine aminopeptidase
L6176_07935	COG2233	PERMEase
L6176_07940	COG2311	Membrane
L6176_07945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6176_07955	COG0456	acetyltransferase
L6176_08005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6176_08030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L6176_08045	COG1215	transferase activity, transferring glycosyl groups
L6176_08050	COG0438	transferase activity, transferring glycosyl groups
L6176_08065	COG0454	-acetyltransferase
L6176_08085	COG0328	RNA-DNA hybrid ribonuclease activity
L6176_08125	COG1280	lysine exporter protein (LysE YggA)
L6176_08140	COG3162	membrane
L6176_08145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6176_08150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6176_08160	COG0475	glutathione-regulated potassium exporter activity
L6176_08165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6176_08170	COG4978	Transcriptional regulator
L6176_08170	COG0789	Transcriptional regulator
L6176_08180	COG2323	membrane
L6176_08185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L6176_08240	COG1923	regulation of RNA biosynthetic process
L6176_08250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6176_08255	COG1360	Flagellar Motor Protein
L6176_08260	COG2201	protein-glutamate methylesterase activity
L6176_08270	COG1776	CheC inhibitor of MCP methylation
L6176_08270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6176_08285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L6176_08305	COG1256	bacterial-type flagellum assembly
L6176_08330	COG1815	bacterial-type flagellum-dependent cell motility
L6176_08335	COG1558	bacterial-type flagellum-dependent cell motility
L6176_08350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6176_08360	COG1157	protein secretion by the type III secretion system
L6176_08395	COG0784	Response regulator, receiver
L6176_08395	COG0835	chemotaxis
L6176_08405	COG0463	Glycosyl transferase, family 2
L6176_08430	COG0463	Glycosyl transferase, family 2
L6176_08430	COG0457	Tetratricopeptide repeat
L6176_08445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L6176_08450	COG0741	lytic transglycosylase activity
L6176_08465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L6176_08465	COG1776	CheC inhibitor of MCP methylation
L6176_08475	COG1338	Plays a role in the flagellum-specific transport system
L6176_08480	COG1987	bacterial-type flagellum assembly
L6176_08490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6176_08495	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L6176_08500	COG1419	protein localization to endoplasmic reticulum
L6176_08505	COG4786	Flagellar basal body rod
L6176_08510	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6176_08535	COG1309	transcriptional regulator
L6176_08555	COG2329	Antibiotic biosynthesis monooxygenase
L6176_08580	COG0583	DNA-binding transcription factor activity
L6176_08590	COG0725	ABC transporter, periplasmic molybdate-binding protein
L6176_08600	COG1234	tRNA 3'-trailer cleavage
L6176_08625	COG1686	Belongs to the peptidase S11 family
L6176_08635	COG0406	alpha-ribazole phosphatase activity
L6176_08665	COG0367	asparagine synthase
L6176_08695	COG1802	Transcriptional regulator
L6176_08700	COG0697	spore germination
L6176_08705	COG0523	cobalamin synthesis protein
L6176_08710	COG0701	Predicted permease
L6176_08720	COG1216	Glycosyl transferase, family 2
L6176_08720	COG0438	transferase activity, transferring glycosyl groups
L6176_08725	COG1757	Na H antiporter
L6176_08730	COG0114	fumarate hydratase activity
L6176_08755	COG3340	Belongs to the peptidase S51 family
L6176_08775	COG0785	Cytochrome C biogenesis protein
L6176_08805	COG2733	membrane
L6176_08840	COG1131	(ABC) transporter
L6176_08855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6176_08860	COG0528	UMP kinase activity
L6176_08870	COG1027	Aspartate ammonia-lyase
L6176_08875	COG0281	malic enzyme
L6176_08880	COG4191	Histidine kinase
L6176_08885	COG0784	Response regulator, receiver
L6176_08890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6176_08950	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6176_08960	COG2814	Major facilitator Superfamily
L6176_08975	COG1966	Carbon starvation protein
L6176_08990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_09000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L6176_09010	COG2223	nitrite transmembrane transporter activity
L6176_09015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6176_09030	COG2244	polysaccharide biosynthetic process
L6176_09035	COG0733	neurotransmitter:sodium symporter activity
L6176_09045	COG5566	PFAM Mor transcription activator
L6176_09050	COG2323	membrane
L6176_09070	COG2084	Dehydrogenase
L6176_09085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6176_09095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6176_09100	COG0028	Belongs to the TPP enzyme family
L6176_09105	COG0440	acetolactate synthase activity
L6176_09110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L6176_09120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L6176_09145	COG2814	Major facilitator Superfamily
L6176_09150	COG3384	dioxygenase
L6176_09160	COG3279	Response regulator of the LytR AlgR family
L6176_09165	COG0427	acetyl-CoA hydrolase
L6176_09185	COG1073	alpha beta
L6176_09215	COG0535	radical SAM domain protein
L6176_09220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_09240	COG1914	H( )-stimulated, divalent metal cation uptake system
L6176_09255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6176_09285	COG2390	Transcriptional regulator
L6176_09295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_09300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L6176_09315	COG4224	UPF0291 protein
L6176_09335	COG0006	proline dipeptidase activity
L6176_09340	COG2132	Multicopper oxidase
L6176_09355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6176_09370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6176_09385	COG1276	copper resistance
L6176_09385	COG2372	response to copper ion
L6176_09390	COG4549	nuclear export factor GLE1
L6176_09400	COG0697	spore germination
L6176_09405	COG0583	DNA-binding transcription factor activity
L6176_09410	COG1959	2 iron, 2 sulfur cluster binding
L6176_09415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L6176_09420	COG0778	Nitroreductase
L6176_09430	COG0628	permease
L6176_09440	COG1231	oxidoreductase activity
L6176_09445	COG0523	cobalamin synthesis protein
L6176_09460	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_09465	COG2030	dehydratase
L6176_09470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_09480	COG0411	ABC transporter
L6176_09500	COG0583	DNA-binding transcription factor activity
L6176_09510	COG1942	4-Oxalocrotonate Tautomerase
L6176_09520	COG1846	Transcriptional regulator
L6176_09530	COG1271	oxidase subunit
L6176_09535	COG1294	oxidase, subunit
L6176_09540	COG4988	ABC transporter
L6176_09545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L6176_09565	COG1686	Belongs to the peptidase S11 family
L6176_09580	COG0791	NLP P60 protein
L6176_09580	COG1388	LysM domain
L6176_09595	COG0745	RESPONSE REGULATOR receiver
L6176_09600	COG5002	protein histidine kinase activity
L6176_09610	COG0300	oxidoreductase activity
L6176_09645	COG0460	homoserine dehydrogenase
L6176_09670	COG1316	TRANSCRIPTIONal
L6176_09680	COG0745	RESPONSE REGULATOR receiver
L6176_09685	COG5002	protein histidine kinase activity
L6176_09700	COG1285	pathogenesis
L6176_09705	COG1247	-acetyltransferase
L6176_09725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6176_09735	COG1082	Xylose isomerase domain protein TIM barrel
L6176_09750	COG1279	arginine transmembrane transporter activity
L6176_09760	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6176_09800	COG2002	toxin-antitoxin pair type II binding
L6176_09805	COG1404	Belongs to the peptidase S8 family
L6176_09810	COG0640	Transcriptional regulator
L6176_09815	COG0667	Aldo Keto reductase
L6176_09820	COG2814	Major facilitator Superfamily
L6176_09845	COG0840	transmembrane signaling receptor activity
L6176_09860	COG3949	Membrane
L6176_09865	COG0783	Belongs to the Dps family
L6176_09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6176_09890	COG1231	oxidoreductase activity
L6176_09900	COG4989	oxidoreductase activity
L6176_09905	COG0523	cobalamin synthesis protein
L6176_09910	COG0456	acetyltransferase
L6176_09970	COG3443	Belongs to the bacterial solute-binding protein 9 family
L6176_09970	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6176_09980	COG0702	epimerase
L6176_09990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6176_10000	COG4166	transmembrane transport
L6176_10015	COG0406	alpha-ribazole phosphatase activity
L6176_10025	COG5337	Spore coat protein CotH
L6176_10030	COG1051	belongs to the nudix hydrolase family
L6176_10035	COG0586	Pfam SNARE associated Golgi protein
L6176_10040	COG2244	polysaccharide biosynthetic process
L6176_10050	COG0701	Predicted permease
L6176_10055	COG3689	TIGRFAM TIGR03943 family protein
L6176_10060	COG1607	acyl-coa hydrolase
L6176_10070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6176_10085	COG0702	epimerase
L6176_10090	COG2839	Protein conserved in bacteria
L6176_10095	COG1253	flavin adenine dinucleotide binding
L6176_10110	COG1114	Component of the transport system for branched-chain amino acids
L6176_10115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6176_10135	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6176_10145	COG1876	peptidase activity
L6176_10155	COG0154	amidase activity
L6176_10160	COG2211	Major facilitator Superfamily
L6176_10180	COG0561	phosphatase activity
L6176_10190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L6176_10195	COG4106	trans-aconitate 2-methyltransferase activity
L6176_10210	COG1819	glycosyl
L6176_10215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_10220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_10255	COG0456	acetyltransferase
L6176_10310	COG3874	Sporulation protein YtfJ
L6176_10335	COG2226	methyltransferase
L6176_10360	COG0346	lactoylglutathione lyase activity
L6176_10370	COG0604	alcohol dehydrogenase
L6176_10375	COG1595	DNA-templated transcription, initiation
L6176_10400	COG0386	Belongs to the glutathione peroxidase family
L6176_10405	COG1305	Transglutaminase-like
L6176_10410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L6176_10415	COG0714	Associated with various cellular activities
L6176_10430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
L6176_10435	COG1140	nitrate reductase beta subunit
L6176_10440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
L6176_10445	COG2181	nitrate reductase activity
L6176_10465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6176_10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L6176_10475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6176_10480	COG0303	'Molybdopterin
L6176_10485	COG0314	molybdopterin synthase activity
L6176_10495	COG2223	nitrite transmembrane transporter activity
L6176_10510	COG1648	precorrin-2 dehydrogenase activity
L6176_10520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L6176_10520	COG1587	Uroporphyrinogen-III synthase
L6176_10525	COG2146	nitrite reductase [NAD(P)H] activity
L6176_10530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L6176_10535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
L6176_10570	COG2359	stage V sporulation protein S
L6176_10595	COG1418	mRNA catabolic process
L6176_10600	COG0488	(ABC) transporter
L6176_10615	COG0629	single-stranded DNA binding
L6176_10630	COG1413	lyase activity
L6176_10645	COG2521	methyltransferase
L6176_10645	COG2136	Putative SAM-dependent methyltransferase
L6176_10650	COG0018	arginyl-trna synthetase
L6176_10675	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L6176_10695	COG0017	Asparaginyl-tRNA synthetase
L6176_10715	COG1674	ftsk spoiiie
L6176_10785	COG1929	Belongs to the glycerate kinase type-1 family
L6176_10790	COG0471	metal ion transport
L6176_10795	COG0745	RESPONSE REGULATOR receiver
L6176_10800	COG3850	Histidine kinase
L6176_10800	COG5002	protein histidine kinase activity
L6176_10815	COG0733	neurotransmitter:sodium symporter activity
L6176_10840	COG2610	gluconate transmembrane transporter activity
L6176_10845	COG1454	alcohol dehydrogenase
L6176_10850	COG1794	racemase activity, acting on amino acids and derivatives
L6176_10860	COG0456	acetyltransferase
L6176_10875	COG1131	(ABC) transporter
L6176_10890	COG0546	phosphoglycolate phosphatase activity
L6176_10910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6176_10925	COG0768	penicillin binding
L6176_10930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L6176_10935	COG0204	Acyl-transferase
L6176_10940	COG1272	protein, Hemolysin III
L6176_10950	COG0805	protein transport
L6176_10960	COG1307	EDD domain protein, DegV family
L6176_10965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L6176_10970	COG1999	signal sequence binding
L6176_10975	COG0071	Belongs to the small heat shock protein (HSP20) family
L6176_10980	COG0367	asparagine synthase
L6176_10995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_11000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L6176_11035	COG0668	transmembrane transport
L6176_11040	COG4585	Histidine kinase
L6176_11040	COG2203	Gaf domain
L6176_11045	COG2197	response regulator
L6176_11055	COG1064	alcohol dehydrogenase
L6176_11110	COG1125	glycine betaine transport
L6176_11110	COG0517	IMP dehydrogenase activity
L6176_11115	COG1174	glycine betaine transport
L6176_11150	COG1253	flavin adenine dinucleotide binding
L6176_11155	COG1012	belongs to the aldehyde dehydrogenase family
L6176_11160	COG5506	Protein of unknown function (DUF1694)
L6176_11175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6176_11180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L6176_11185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L6176_11190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L6176_11195	COG0456	acetyltransferase
L6176_11200	COG3829	transcription factor binding
L6176_11205	COG1509	lysine 2,3-aminomutase activity
L6176_11245	COG4326	sporulation control protein
L6176_11250	COG0671	phosphoesterase, PA-phosphatase related
L6176_11255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6176_11260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6176_11290	COG1715	Restriction endonuclease
L6176_11290	COG1787	Restriction endonuclease
L6176_11380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L6176_11430	COG2814	Major facilitator Superfamily
L6176_11435	COG4841	protein insertion into membrane
L6176_11440	COG0372	Belongs to the citrate synthase family
L6176_11445	COG2079	MmgE PrpD family protein
L6176_11450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L6176_11455	COG1960	acyl-CoA dehydrogenase activity
L6176_11460	COG2084	Dehydrogenase
L6176_11470	COG1280	lysine exporter protein (LysE YggA)
L6176_11475	COG1024	Enoyl-CoA hydratase
L6176_11490	COG0420	3'-5' exonuclease activity
L6176_11495	COG0419	ATPase involved in DNA repair
L6176_11515	COG2223	nitrite transmembrane transporter activity
L6176_11520	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_11525	COG1169	isochorismate synthase
L6176_11530	COG1021	2,3-dihydroxybenzoate-AMP ligase
L6176_11535	COG3433	isochorismatase activity
L6176_11535	COG1535	isochorismatase
L6176_11540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L6176_11545	COG3251	PFAM MbtH domain protein
L6176_11550	COG2814	Major facilitator Superfamily
L6176_11565	COG0776	regulation of translation
L6176_11575	COG2318	DinB family
L6176_11585	COG1115	amino acid carrier protein
L6176_11600	COG2329	Antibiotic biosynthesis monooxygenase
L6176_11605	COG1187	pseudouridine synthase activity
L6176_11610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6176_11625	COG0596	Alpha beta hydrolase
L6176_11630	COG2814	Major facilitator Superfamily
L6176_11650	COG2226	methyltransferase
L6176_11695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_11730	COG1247	-acetyltransferase
L6176_11760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L6176_11770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_11780	COG1278	Cold shock
L6176_11795	COG0010	Belongs to the arginase family
L6176_11800	COG0561	phosphatase activity
L6176_11840	COG0583	DNA-binding transcription factor activity
L6176_11845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6176_11860	COG0583	DNA-binding transcription factor activity
L6176_11865	COG2258	MOSC domain
L6176_11880	COG1132	(ABC) transporter
L6176_11885	COG1132	(ABC) transporter
L6176_11905	COG1396	sequence-specific DNA binding
L6176_11930	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
L6176_11935	COG1595	DNA-templated transcription, initiation
L6176_11960	COG1649	PFAM Uncharacterised BCR, COG1649
L6176_11985	COG2971	BadF BadG BcrA BcrD
L6176_11990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6176_11995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L6176_12015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_12045	COG1309	transcriptional regulator
L6176_12060	COG0577	efflux transmembrane transporter activity
L6176_12060	COG1136	(ABC) transporter
L6176_12065	COG3615	Tellurite resistance protein tehB
L6176_12065	COG0500	methyltransferase
L6176_12075	COG2226	methyltransferase
L6176_12080	COG3961	Belongs to the TPP enzyme family
L6176_12085	COG1846	Transcriptional regulator
L6176_12125	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6176_12140	COG1595	DNA-templated transcription, initiation
L6176_12150	COG0768	penicillin binding
L6176_12160	COG2367	Beta-lactamase
L6176_12165	COG0671	phosphoesterase, PA-phosphatase related
L6176_12175	COG2814	Major facilitator Superfamily
L6176_12180	COG0673	inositol 2-dehydrogenase activity
L6176_12190	COG1012	belongs to the aldehyde dehydrogenase family
L6176_12205	COG0191	fructose-bisphosphate aldolase activity
L6176_12210	COG3718	enzyme involved in inositol metabolism
L6176_12235	COG0457	Tetratricopeptide repeat
L6176_12240	COG1476	TRANSCRIPTIONal
L6176_12255	COG1876	peptidase activity
L6176_12275	COG1309	transcriptional regulator
L6176_12280	COG0488	(ABC) transporter
L6176_12295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_12310	COG1252	NADH dehydrogenase
L6176_12315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6176_12330	COG1131	(ABC) transporter
L6176_12340	COG1309	transcriptional regulator
L6176_12355	COG1960	acyl-CoA dehydrogenase activity
L6176_12360	COG0439	Biotin carboxylase
L6176_12365	COG0511	ligase activity, forming carbon-carbon bonds
L6176_12370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L6176_12375	COG1024	Enoyl-CoA hydratase
L6176_12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L6176_12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6176_12395	COG1247	-acetyltransferase
L6176_12400	COG0572	uridine kinase
L6176_12410	COG2318	DinB family
L6176_12415	COG1686	Belongs to the peptidase S11 family
L6176_12440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L6176_12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6176_12480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6176_12505	COG2814	Major facilitator Superfamily
L6176_12525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6176_12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_12560	COG1063	alcohol dehydrogenase
L6176_12590	COG3773	Cell wall hydrolase
L6176_12600	COG0745	RESPONSE REGULATOR receiver
L6176_12615	COG0488	(ABC) transporter
L6176_12630	COG1136	(ABC) transporter
L6176_12655	COG0460	homoserine dehydrogenase
L6176_12660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_12670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L6176_12735	COG2124	cytochrome p450
L6176_12770	COG0561	phosphatase activity
L6176_12780	COG0768	penicillin binding
L6176_12785	COG1819	glycosyl
L6176_12790	COG1794	racemase activity, acting on amino acids and derivatives
L6176_12800	COG1122	ATPase activity
L6176_12815	COG2205	protein histidine kinase activity
L6176_12825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6176_12830	COG0604	alcohol dehydrogenase
L6176_12835	COG0768	penicillin binding
L6176_12845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6176_12880	COG0693	protein deglycase activity
L6176_12910	COG2814	Major facilitator Superfamily
L6176_12925	COG0584	glycerophosphoryl diester phosphodiesterase
L6176_12945	COG0697	spore germination
L6176_12975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6176_12985	COG2223	nitrite transmembrane transporter activity
L6176_13000	COG2816	NAD+ diphosphatase activity
L6176_13005	COG0592	DNA-directed DNA polymerase activity
L6176_13010	COG1051	belongs to the nudix hydrolase family
L6176_13045	COG3878	Protein conserved in bacteria
L6176_13095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L6176_13110	COG0322	excinuclease ABC activity
L6176_13150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6176_13175	COG1011	Hydrolase
L6176_13195	COG0076	glutamate decarboxylase activity
L6176_13210	COG1523	belongs to the glycosyl hydrolase 13 family
L6176_13215	COG3227	Zinc metalloprotease (Elastase)
L6176_13235	COG0201	protein transport
L6176_13245	COG0697	spore germination
L6176_13250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_13280	COG4129	membrane
L6176_13285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_13300	COG2959	enzyme of heme biosynthesis
L6176_13320	COG3483	tryptophan 2,3-dioxygenase activity
L6176_13325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
L6176_13330	COG3844	kynureninase activity
L6176_13335	COG1309	transcriptional regulator
L6176_13365	COG3284	Transcriptional regulator
L6176_13385	COG1349	DNA-binding transcription factor activity
L6176_13405	COG1959	2 iron, 2 sulfur cluster binding
L6176_13420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6176_13425	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6176_13430	COG0022	dehydrogenase e1 component
L6176_13435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6176_13445	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_13450	COG0456	acetyltransferase
L6176_13450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6176_13480	COG4176	ABC-type proline glycine betaine transport system permease component
L6176_13485	COG4175	Glycine betaine
L6176_13485	COG0517	IMP dehydrogenase activity
L6176_13510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
L6176_13515	COG2153	protein acetylation
L6176_13520	COG3397	chitin binding
L6176_13535	COG2205	protein histidine kinase activity
L6176_13560	COG0658	competence protein
L6176_13560	COG2333	competence protein COMEC
L6176_13610	COG3973	AAA domain
L6176_13625	COG2105	PFAM AIG2 family protein
L6176_13630	COG0514	ATP-dependent DNA helicase (RecQ)
L6176_13650	COG4637	Psort location Cytoplasmic, score
L6176_13675	COG3397	chitin binding
L6176_13690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L6176_13695	COG1115	amino acid carrier protein
L6176_13700	COG1012	belongs to the aldehyde dehydrogenase family
L6176_13705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L6176_13715	COG3938	Belongs to the proline racemase family
L6176_13720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L6176_13760	COG0586	Pfam SNARE associated Golgi protein
L6176_13775	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L6176_13780	COG0519	Catalyzes the synthesis of GMP from XMP
L6176_13785	COG4166	transmembrane transport
L6176_13795	COG4948	Mandelate Racemase Muconate Lactonizing
L6176_13840	COG2936	dipeptidyl-peptidase activity
L6176_13845	COG5002	protein histidine kinase activity
L6176_13895	COG1307	EDD domain protein, DegV family
L6176_13915	COG2814	Major facilitator Superfamily
L6176_13925	COG1664	Polymer-forming cytoskeletal
L6176_13930	COG0789	Transcriptional regulator
L6176_13935	COG4533	DNA binding
L6176_13940	COG0477	Major facilitator Superfamily
L6176_13940	COG2814	Major facilitator Superfamily
L6176_13960	COG2261	transglycosylase associated protein
L6176_13975	COG2226	methyltransferase
L6176_14010	COG0436	Aminotransferase
L6176_14015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L6176_14020	COG5146	pantothenate kinase activity
L6176_14040	COG1131	(ABC) transporter
L6176_14085	COG0628	permease
L6176_14100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6176_14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6176_14110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6176_14115	COG1116	anion transmembrane transporter activity
L6176_14135	COG2816	NAD+ diphosphatase activity
L6176_14155	COG2746	aminoglycoside 3-N-acetyltransferase activity
L6176_14180	COG0697	spore germination
L6176_14185	COG2318	DinB family
L6176_14205	COG4912	Dna alkylation repair
L6176_14225	COG0861	Integral membrane protein TerC family
L6176_14230	COG1368	sulfuric ester hydrolase activity
L6176_14235	COG0488	(ABC) transporter
L6176_14250	COG1309	transcriptional regulator
L6176_14265	COG0287	Prephenate dehydrogenase
L6176_14270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L6176_14275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L6176_14280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L6176_14280	COG1605	Chorismate mutase
L6176_14315	COG3584	3D domain protein
L6176_14315	COG1388	LysM domain
L6176_14325	COG1595	DNA-templated transcription, initiation
L6176_14350	COG1879	ABC-type sugar transport system periplasmic component
L6176_14360	COG1172	Belongs to the binding-protein-dependent transport system permease family
L6176_14370	COG2390	Transcriptional regulator
L6176_14405	COG2329	Antibiotic biosynthesis monooxygenase
L6176_14425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_14435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L6176_14440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6176_14445	COG4187	Peptidase family M20/M25/M40
L6176_14450	COG1414	Transcriptional regulator
L6176_14455	COG0833	amino acid
L6176_14460	COG1690	Belongs to the RtcB family
L6176_14470	COG1785	Belongs to the alkaline phosphatase family
L6176_14480	COG3655	Transcriptional regulator
L6176_14495	COG4377	Putative membrane peptidase family (DUF2324)
L6176_14505	COG3279	Response regulator of the LytR AlgR family
L6176_14515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_14520	COG0346	lactoylglutathione lyase activity
L6176_14540	COG0714	Associated with various cellular activities
L6176_14565	COG0463	Glycosyl transferase, family 2
L6176_14585	COG0463	Glycosyl transferase, family 2
L6176_14595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6176_14600	COG0753	catalase activity
L6176_14610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L6176_14635	COG0714	Associated with various cellular activities
L6176_14645	COG0778	Nitroreductase
L6176_14650	COG1846	Transcriptional regulator
L6176_14685	COG1725	Transcriptional regulator
L6176_14695	COG1136	(ABC) transporter
L6176_14695	COG0577	efflux transmembrane transporter activity
L6176_14720	COG2207	Transcriptional regulator
L6176_14725	COG0456	acetyltransferase
L6176_14745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_14765	COG0642	Histidine kinase
L6176_14770	COG0745	RESPONSE REGULATOR receiver
L6176_14775	COG0596	Alpha beta hydrolase
L6176_14805	COG0730	response to heat
L6176_14815	COG0833	amino acid
L6176_14825	COG4335	DNA alkylation repair
L6176_14865	COG0768	penicillin binding
L6176_14875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L6176_14910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L6176_14915	COG1414	Transcriptional regulator
L6176_14930	COG0860	N-Acetylmuramoyl-L-alanine amidase
L6176_14935	COG0640	Transcriptional regulator
L6176_14945	COG1960	acyl-CoA dehydrogenase activity
L6176_14960	COG3314	Sporulation integral membrane protein YlbJ
L6176_14975	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L6176_14990	COG3848	Pyruvate phosphate dikinase
L6176_14990	COG0574	Belongs to the PEP-utilizing enzyme family
L6176_14995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_15010	COG5577	PFAM Coat F domain
L6176_15015	COG3403	YqcI/YcgG family
L6176_15020	COG1280	lysine exporter protein (LysE YggA)
L6176_15055	COG1063	alcohol dehydrogenase
L6176_15070	COG1027	Aspartate ammonia-lyase
L6176_15075	COG0252	asparaginase activity
L6176_15080	COG1396	sequence-specific DNA binding
L6176_15090	COG0322	excinuclease ABC activity
L6176_15095	COG0531	amino acid
L6176_15100	COG1114	Component of the transport system for branched-chain amino acids
L6176_15105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6176_15115	COG0281	malic enzyme
L6176_15130	COG0531	amino acid
L6176_15140	COG0784	Response regulator, receiver
L6176_15150	COG2066	Belongs to the glutaminase family
L6176_15155	COG1115	amino acid carrier protein
L6176_15185	COG0737	Belongs to the 5'-nucleotidase family
L6176_15190	COG0753	catalase activity
L6176_15195	COG2267	carboxylic ester hydrolase activity
L6176_15200	COG1335	isochorismatase
L6176_15220	COG0583	DNA-binding transcription factor activity
L6176_15270	COG0415	Belongs to the DNA photolyase family
L6176_15275	COG0288	reversible hydration of carbon dioxide
L6176_15285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6176_15290	COG5609	conserved protein (DUF2294)
L6176_15305	COG1575	Belongs to the MenA family. Type 1 subfamily
L6176_15310	COG2267	carboxylic ester hydrolase activity
L6176_15315	COG0803	Belongs to the bacterial solute-binding protein 9 family
L6176_15320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6176_15325	COG1121	(ABC) transporter
L6176_15355	COG0798	PFAM Bile acid sodium symporter
L6176_15360	COG0346	lactoylglutathione lyase activity
L6176_15365	COG0640	Transcriptional regulator
L6176_15380	COG0443	Heat shock 70 kDa protein
L6176_15395	COG1522	sequence-specific DNA binding
L6176_15410	COG0346	lactoylglutathione lyase activity
L6176_15430	COG2169	Transcriptional regulator
L6176_15435	COG2169	Transcriptional regulator
L6176_15480	COG2814	Major facilitator Superfamily
L6176_15505	COG0745	RESPONSE REGULATOR receiver
L6176_15510	COG3850	Histidine kinase
L6176_15510	COG5002	protein histidine kinase activity
L6176_15535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L6176_15555	COG1476	TRANSCRIPTIONal
L6176_15570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_15575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L6176_15585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_15590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L6176_15605	COG1136	(ABC) transporter
L6176_15610	COG0577	efflux transmembrane transporter activity
L6176_15625	COG5002	protein histidine kinase activity
L6176_15625	COG3850	Histidine kinase
L6176_15635	COG2364	Membrane
L6176_15640	COG1846	Transcriptional regulator
L6176_15650	COG2808	Putative FMN-binding domain
L6176_15655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_15660	COG2271	Major facilitator Superfamily
L6176_15665	COG1556	Lactate utilization protein
L6176_15670	COG1139	Iron-sulfur cluster binding protein
L6176_15680	COG0583	DNA-binding transcription factor activity
L6176_15690	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6176_15715	COG0673	inositol 2-dehydrogenase activity
L6176_15720	COG0561	phosphatase activity
L6176_15730	COG1609	Transcriptional regulator
L6176_15735	COG0457	Tetratricopeptide repeat
L6176_15755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6176_15785	COG0534	Mate efflux family protein
L6176_15805	COG2814	Major facilitator Superfamily
L6176_15810	COG1309	transcriptional regulator
L6176_15825	COG0814	amino acid
L6176_15830	COG1760	l-serine dehydratase
L6176_15835	COG1760	l-serine dehydratase
L6176_15845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L6176_15850	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
L6176_15860	COG1335	isochorismatase
L6176_15865	COG1522	sequence-specific DNA binding
L6176_15870	COG0531	amino acid
L6176_15890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L6176_15910	COG1595	DNA-templated transcription, initiation
L6176_15925	COG0662	Cupin 2, conserved barrel domain protein
L6176_15930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_15930	COG2207	Transcriptional regulator
L6176_15980	COG0477	Major facilitator Superfamily
L6176_15990	COG1846	Transcriptional regulator
L6176_15995	COG2814	Major facilitator Superfamily
L6176_16005	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6176_16010	COG1131	(ABC) transporter
L6176_16030	COG2076	Multidrug Resistance protein
L6176_16035	COG1309	transcriptional regulator
L6176_16045	COG2031	fatty acid transporter
L6176_16055	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6176_16085	COG1122	ATPase activity
L6176_16090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L6176_16105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L6176_16110	COG1288	antiporter activity
L6176_16115	COG2356	endonuclease I
L6176_16130	COG3620	sequence-specific DNA binding
L6176_16135	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6176_16140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L6176_16145	COG0124	histidyl-tRNA synthetase
L6176_16160	COG1733	regulation of RNA biosynthetic process
L6176_16165	COG0778	Nitroreductase
L6176_16185	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_16195	COG1131	(ABC) transporter
L6176_16220	COG1011	Hydrolase
L6176_16230	COG2365	Tyrosine phosphatase family
L6176_16255	COG0346	lactoylglutathione lyase activity
L6176_16260	COG1940	carbohydrate kinase activity
L6176_16265	COG0738	Major facilitator superfamily
L6176_16270	COG0110	maltose O-acetyltransferase activity
L6176_16280	COG0577	efflux transmembrane transporter activity
L6176_16280	COG1136	(ABC) transporter
L6176_16295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L6176_16300	COG0628	permease
L6176_16320	COG2226	methyltransferase
L6176_16330	COG0477	Major facilitator Superfamily
L6176_16360	COG1253	flavin adenine dinucleotide binding
L6176_16365	COG0789	Transcriptional regulator
L6176_16370	COG0697	spore germination
L6176_16375	COG1357	PFAM Pentapeptide repeats (8 copies)
L6176_16380	COG3813	Protein conserved in bacteria
L6176_16385	COG2706	6-phosphogluconolactonase activity
L6176_16390	COG1070	Carbohydrate kinase
L6176_16400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L6176_16405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
L6176_16415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6176_16420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L6176_16425	COG0604	alcohol dehydrogenase
L6176_16430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L6176_16440	COG0604	alcohol dehydrogenase
L6176_16440	COG3321	synthase
L6176_16445	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_16470	COG0656	L-ascorbic acid biosynthetic process
L6176_16475	COG2814	Major facilitator Superfamily
L6176_16490	COG0346	lactoylglutathione lyase activity
L6176_16495	COG0814	amino acid
L6176_16520	COG1393	Belongs to the ArsC family
L6176_16525	COG1733	regulation of RNA biosynthetic process
L6176_16530	COG2188	Transcriptional regulator
L6176_16540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L6176_16545	COG1733	regulation of RNA biosynthetic process
L6176_16550	COG1733	regulation of RNA biosynthetic process
L6176_16565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_16585	COG0384	phenazine biosynthesis protein PhzF
L6176_16595	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_16605	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_16615	COG1733	regulation of RNA biosynthetic process
L6176_16645	COG1191	sigma factor activity
L6176_16660	COG1309	transcriptional regulator
L6176_16680	COG3152	Membrane
L6176_16705	COG1151	hydroxylamine reductase activity
L6176_16715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_16720	COG3757	hydrolase, family 25
L6176_16720	COG3409	Peptidoglycan-binding domain 1 protein
L6176_16755	COG2072	flavoprotein involved in K transport
L6176_16790	COG0604	alcohol dehydrogenase
L6176_16795	COG1113	amino acid transport
L6176_16800	COG2814	Major facilitator Superfamily
L6176_16830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6176_16835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6176_16860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_16865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_16870	COG3739	integral membrane protein
L6176_16875	COG0384	phenazine biosynthesis protein PhzF
L6176_16905	COG0583	DNA-binding transcription factor activity
L6176_16925	COG1193	negative regulation of DNA recombination
L6176_16950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L6176_16980	COG0584	glycerophosphoryl diester phosphodiesterase
L6176_17005	COG0640	Transcriptional regulator
L6176_17010	COG0604	alcohol dehydrogenase
L6176_17030	COG2808	Putative FMN-binding domain
L6176_17035	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6176_17045	COG0385	Bile acid
L6176_17050	COG0277	FAD linked oxidase domain protein
L6176_17080	COG1216	Glycosyl transferase, family 2
L6176_17085	COG1024	Enoyl-CoA hydratase
L6176_17095	COG1285	pathogenesis
L6176_17110	COG2514	catechol 2,3-dioxygenase activity
L6176_17115	COG2720	vancomycin resistance protein
L6176_17155	COG0716	FMN binding
L6176_17185	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_17195	COG0165	Argininosuccinate lyase
L6176_17210	COG4145	pantothenate transmembrane transporter activity
L6176_17220	COG1012	belongs to the aldehyde dehydrogenase family
L6176_17225	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_17235	COG1657	PFAM Prenyltransferase squalene oxidase
L6176_17240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L6176_17245	COG2962	Rard protein
L6176_17250	COG3326	Membrane
L6176_17265	COG0489	protein tyrosine kinase activity
L6176_17275	COG0314	molybdopterin synthase activity
L6176_17280	COG0303	'Molybdopterin
L6176_17285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6176_17290	COG2116	formate transmembrane transporter activity
L6176_17300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L6176_17305	COG5609	conserved protein (DUF2294)
L6176_17310	COG2427	Protein of unknown function (DUF1641)
L6176_17315	COG3383	formate dehydrogenase (NAD+) activity
L6176_17325	COG0697	spore germination
L6176_17365	COG2226	methyltransferase
L6176_17370	COG4166	transmembrane transport
L6176_17380	COG4166	transmembrane transport
L6176_17385	COG1301	dicarboxylic acid transport
L6176_17390	COG1316	TRANSCRIPTIONal
L6176_17400	COG1595	DNA-templated transcription, initiation
L6176_17420	COG1131	(ABC) transporter
L6176_17430	COG0673	inositol 2-dehydrogenase activity
L6176_17435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L6176_17440	COG0187	DNA topoisomerase II activity
L6176_17445	COG1832	CoA-binding protein
L6176_17450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6176_17455	COG0745	RESPONSE REGULATOR receiver
L6176_17470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L6176_17475	COG4841	protein insertion into membrane
L6176_17480	COG0824	Thioesterase
L6176_17510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6176_17520	COG2274	protein secretion by the type I secretion system
L6176_17525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L6176_17565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6176_17580	COG0183	Belongs to the thiolase family
L6176_17585	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_17590	COG1268	BioY protein
L6176_17595	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_17645	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_17655	COG5002	protein histidine kinase activity
L6176_17660	COG0400	carboxylic ester hydrolase activity
L6176_17665	COG0346	lactoylglutathione lyase activity
L6176_17670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L6176_17675	COG0069	glutamate synthase activity
L6176_17680	COG1902	pentaerythritol trinitrate reductase activity
L6176_17685	COG1329	Transcriptional regulator
L6176_17690	COG0010	Belongs to the arginase family
L6176_17715	COG2226	methyltransferase
L6176_17750	COG4846	Membrane protein involved in cytochrome C biogenesis
L6176_17755	COG0785	Cytochrome C biogenesis protein
L6176_17765	COG0583	DNA-binding transcription factor activity
L6176_17770	COG1380	Effector of murein hydrolase LrgA
L6176_17775	COG1346	cytolysis
L6176_17800	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6176_17800	COG3409	Peptidoglycan-binding domain 1 protein
L6176_17815	COG1132	(ABC) transporter
L6176_17820	COG1132	(ABC) transporter
L6176_17850	COG3639	organic phosphonate transmembrane transporter activity
L6176_17855	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
L6176_17875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L6176_17895	COG1695	Transcriptional regulator
L6176_17935	COG5632	N-Acetylmuramoyl-L-alanine amidase
L6176_17935	COG3409	Peptidoglycan-binding domain 1 protein
L6176_17935	COG1388	LysM domain
L6176_17940	COG4824	toxin secretion phage lysis holin
L6176_18095	COG1595	DNA-templated transcription, initiation
L6176_18140	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
L6176_18220	COG1396	sequence-specific DNA binding
L6176_18245	COG0174	glutamine synthetase
L6176_18250	COG0789	Transcriptional regulator
L6176_18255	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L6176_18265	COG2860	membrane
L6176_18270	COG0464	growth
L6176_18300	COG1388	LysM domain
L6176_18300	COG3584	3D domain protein
L6176_18305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6176_18305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6176_18305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L6176_18310	COG1105	Belongs to the carbohydrate kinase PfkB family
L6176_18315	COG1349	DNA-binding transcription factor activity
L6176_18325	COG2322	membrane
L6176_18335	COG1113	amino acid transport
L6176_18350	COG1408	metallophosphoesterase
L6176_18355	COG2116	formate transmembrane transporter activity
L6176_18365	COG2217	Heavy metal translocating P-type atpase
L6176_18370	COG2608	mercury ion transmembrane transporter activity
L6176_18375	COG1937	Protein conserved in bacteria
L6176_18385	COG2819	hydrolase of the alpha beta superfamily
L6176_18390	COG1120	ATPase activity
L6176_18395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_18400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_18410	COG0708	Exodeoxyribonuclease III
L6176_18415	COG2169	Transcriptional regulator
L6176_18420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L6176_18425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L6176_18435	COG2364	Membrane
L6176_18450	COG2267	carboxylic ester hydrolase activity
L6176_18455	COG0346	lactoylglutathione lyase activity
L6176_18460	COG3300	MHYT domain
L6176_18460	COG5001	Diguanylate cyclase
L6176_18480	COG1346	cytolysis
L6176_18485	COG1380	Effector of murein hydrolase LrgA
L6176_18490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L6176_18495	COG0596	Alpha beta hydrolase
L6176_18495	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6176_18500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L6176_18520	COG1404	Belongs to the peptidase S8 family
L6176_18525	COG3773	Cell wall hydrolase
L6176_18530	COG0562	UDP-galactopyranose mutase
L6176_18535	COG1368	sulfuric ester hydrolase activity
L6176_18540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L6176_18550	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
L6176_18575	COG1131	(ABC) transporter
L6176_18595	COG4550	Control of competence regulator ComK, YlbF/YmcA
L6176_18600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6176_18605	COG1013	pyruvate-flavodoxin oxidoreductase activity
L6176_18610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L6176_18610	COG0674	pyruvate-flavodoxin oxidoreductase activity
L6176_18620	COG2359	stage V sporulation protein S
L6176_18625	COG1692	metallophosphoesterase
L6176_18650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L6176_18655	COG1426	Protein conserved in bacteria
L6176_18670	COG0300	oxidoreductase activity
L6176_18675	COG0612	Peptidase, M16
L6176_18680	COG0612	Peptidase, M16
L6176_18685	COG1079	Belongs to the binding-protein-dependent transport system permease family
L6176_18695	COG3845	ABC transporter
L6176_18700	COG1744	ABC transporter substrate-binding protein PnrA-like
L6176_18705	COG2188	Transcriptional regulator
L6176_18710	COG1674	ftsk spoiiie
L6176_18720	COG0740	serine-type endopeptidase activity
L6176_18725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6176_18735	COG0527	aspartate kinase activity
L6176_18740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L6176_18745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6176_18750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6176_18755	COG1873	PFAM PRC-barrel domain
L6176_18760	COG0612	Peptidase, M16
L6176_18765	COG0726	polysaccharide deacetylase
L6176_18780	COG0196	riboflavin kinase activity
L6176_18785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L6176_18795	COG1550	Protein conserved in bacteria
L6176_18805	COG1358	cellular component organization or biogenesis
L6176_18810	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L6176_18815	COG0195	Participates in both transcription termination and antitermination
L6176_18835	COG0750	zinc metalloprotease
L6176_18845	COG4589	Belongs to the CDS family
L6176_18850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L6176_18860	COG0528	UMP kinase activity
L6176_18890	COG4974	Belongs to the 'phage' integrase family
L6176_18900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L6176_18910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L6176_18950	COG1837	Belongs to the UPF0109 family
L6176_18960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L6176_18970	COG0552	protein localization to endoplasmic reticulum
L6176_18975	COG1196	nuclear chromosome segregation
L6176_18985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L6176_18990	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_18995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L6176_19010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L6176_19015	COG1461	Dihydroxyacetone kinase
L6176_19020	COG1302	Protein conserved in bacteria
L6176_19035	COG1564	THIamine pyrophosphokinase
L6176_19040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L6176_19045	COG1162	GTPase activity
L6176_19050	COG0515	serine threonine protein kinase
L6176_19050	COG2815	serine threonine protein kinase
L6176_19055	COG0631	protein serine/threonine phosphatase activity
L6176_19065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L6176_19065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L6176_19075	COG0242	peptide deformylase activity
L6176_19080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L6176_19085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L6176_19105	COG1561	YicC-like family, N-terminal region
L6176_19110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L6176_19120	COG0006	proline dipeptidase activity
L6176_19135	COG3069	C4-dicarboxylate transmembrane transporter activity
L6176_19200	COG0564	pseudouridine synthase activity
L6176_19220	COG3599	regulation of cell shape
L6176_19225	COG2302	S4 RNA-binding domain
L6176_19230	COG0762	integral membrane protein
L6176_19240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L6176_19245	COG1496	oxidoreductase activity
L6176_19250	COG1873	PFAM PRC-barrel domain
L6176_19255	COG1191	sigma factor activity
L6176_19260	COG1191	sigma factor activity
L6176_19270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L6176_19275	COG0849	cell division
L6176_19280	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L6176_19285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6176_19295	COG0772	Belongs to the SEDS family
L6176_19310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L6176_19315	COG0768	penicillin binding
L6176_19320	COG0768	penicillin binding
L6176_19325	COG4839	cell division protein FtsL
L6176_19340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L6176_19355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L6176_19360	COG1399	metal-binding, possibly nucleic acid-binding protein
L6176_19410	COG4824	toxin secretion phage lysis holin
L6176_19505	COG4626	Terminase
L6176_19505	COG1802	Transcriptional regulator
L6176_19530	COG0582	viral genome integration into host DNA
L6176_19595	COG0756	dUTP diphosphatase activity
L6176_19610	COG1191	sigma factor activity
L6176_19635	COG1484	DNA-dependent DNA replication
L6176_19665	COG1396	sequence-specific DNA binding
L6176_19680	COG1396	sequence-specific DNA binding
L6176_19695	COG0582	viral genome integration into host DNA
L6176_19705	COG3480	Lon protease (S16) C-terminal proteolytic domain
L6176_19710	COG1752	Esterase of the alpha-beta hydrolase superfamily
L6176_19715	COG3314	Sporulation integral membrane protein YlbJ
L6176_19725	COG0742	ribosomal rna small subunit methyltransferase
L6176_19740	COG3679	Belongs to the UPF0342 family
L6176_19745	COG0406	alpha-ribazole phosphatase activity
L6176_19760	COG2340	Cysteine-rich secretory protein family
L6176_19775	COG3336	cytochrome c oxidase
L6176_19810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L6176_19815	COG0772	Belongs to the SEDS family
L6176_19825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L6176_19830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L6176_19840	COG4896	Protein conserved in bacteria
L6176_19855	COG1217	gtp-binding protein TYPA
L6176_19865	COG0483	inositol monophosphate 1-phosphatase activity
L6176_19885	COG1982	Orn Lys Arg decarboxylase major
L6176_19930	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6176_19935	COG0022	dehydrogenase e1 component
L6176_19940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6176_19950	COG0242	peptide deformylase activity
L6176_19955	COG0561	phosphatase activity
L6176_19965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L6176_19970	COG0569	domain protein
L6176_19990	COG0583	DNA-binding transcription factor activity
L6176_19995	COG0517	IMP dehydrogenase activity
L6176_20005	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L6176_20015	COG4703	Protein of unknown function (DUF1797)
L6176_20030	COG2200	EAL domain
L6176_20035	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_20040	COG1408	metallophosphoesterase
L6176_20050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L6176_20085	COG2814	Major facilitator Superfamily
L6176_20105	COG3209	COG3209 Rhs family protein
L6176_20115	COG2205	protein histidine kinase activity
L6176_20125	COG0436	Aminotransferase
L6176_20130	COG1609	Transcriptional regulator
L6176_20135	COG3833	ABC-type maltose transport systems, permease component
L6176_20140	COG1175	transmembrane transport
L6176_20145	COG2182	Extracellular solute-binding protein
L6176_20155	COG0366	Alpha amylase catalytic
L6176_20160	COG3842	ATPase activity
L6176_20200	COG0183	Belongs to the thiolase family
L6176_20235	COG1695	Transcriptional regulator
L6176_20240	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_20250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L6176_20260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L6176_20265	COG0436	Aminotransferase
L6176_20285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L6176_20305	COG2199	diguanylate cyclase activity
L6176_20310	COG0778	Nitroreductase
L6176_20335	COG2190	(PTS) system
L6176_20335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L6176_20335	COG1263	PTS System
L6176_20340	COG3711	transcriptional antiterminator
L6176_20350	COG2188	Transcriptional regulator
L6176_20360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L6176_20385	COG1547	Domain of unknown function (DUF309)
L6176_20390	COG0456	acetyltransferase
L6176_20400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L6176_20405	COG4086	secreted protein
L6176_20410	COG0561	phosphatase activity
L6176_20415	COG0697	spore germination
L6176_20430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_20455	COG0733	neurotransmitter:sodium symporter activity
L6176_20475	COG1686	Belongs to the peptidase S11 family
L6176_20480	COG1725	Transcriptional regulator
L6176_20485	COG1131	(ABC) transporter
L6176_20500	COG1846	Transcriptional regulator
L6176_20515	COG0598	Magnesium transport protein CorA
L6176_20540	COG4974	Belongs to the 'phage' integrase family
L6176_20550	COG0735	belongs to the Fur family
L6176_20555	COG1300	Membrane
L6176_20575	COG0667	Aldo Keto reductase
L6176_20580	COG0656	L-ascorbic acid biosynthetic process
L6176_20585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L6176_20585	COG0456	acetyltransferase
L6176_20595	COG0737	Belongs to the 5'-nucleotidase family
L6176_20595	COG1525	nuclease
L6176_20595	COG4085	toxin activity
L6176_20605	COG0596	Alpha beta hydrolase
L6176_20610	COG2056	Na+-H+ antiporter family
L6176_20615	COG1609	Transcriptional regulator
L6176_20620	COG0456	acetyltransferase
L6176_20625	COG1073	alpha beta
L6176_20640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6176_20640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L6176_20645	COG0307	riboflavin synthase, alpha
L6176_20670	COG4106	trans-aconitate 2-methyltransferase activity
L6176_20675	COG1073	alpha beta
L6176_20675	COG2226	methyltransferase
L6176_20690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L6176_20700	COG1757	Na H antiporter
L6176_20705	COG0737	Belongs to the 5'-nucleotidase family
L6176_20715	COG1522	sequence-specific DNA binding
L6176_20735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L6176_20745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L6176_20760	COG0300	oxidoreductase activity
L6176_20770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6176_20775	COG1760	l-serine dehydratase
L6176_20780	COG1760	l-serine dehydratase
L6176_20800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L6176_20810	COG2195	Cleaves the N-terminal amino acid of tripeptides
L6176_20815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_20830	COG1376	ErfK ybiS ycfS ynhG family protein
L6176_20835	COG4129	membrane
L6176_20840	COG1126	abc transporter atp-binding protein
L6176_20845	COG0765	amino acid transport
L6176_20850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L6176_20865	COG2816	NAD+ diphosphatase activity
L6176_20870	COG0772	Belongs to the SEDS family
L6176_20875	COG0508	dehydrogenase complex catalyzes the overall conversion of
L6176_20880	COG0022	dehydrogenase e1 component
L6176_20885	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L6176_20890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L6176_20905	COG0280	phosphate acetyltransferase
L6176_20910	COG3290	protein histidine kinase activity
L6176_20910	COG3829	transcription factor binding
L6176_20920	COG0584	glycerophosphoryl diester phosphodiesterase
L6176_20925	COG3093	addiction module antidote protein HigA
L6176_20935	COG0745	RESPONSE REGULATOR receiver
L6176_20940	COG0750	zinc metalloprotease
L6176_20945	COG0497	DNA recombination
L6176_20955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L6176_20965	COG0142	geranyltranstransferase activity
L6176_20990	COG1302	Protein conserved in bacteria
L6176_20995	COG0439	Biotin carboxylase
L6176_21000	COG0511	ligase activity, forming carbon-carbon bonds
L6176_21045	COG3854	ATPases associated with a variety of cellular activities
L6176_21070	COG0006	proline dipeptidase activity
L6176_21085	COG3872	metal-dependent enzyme
L6176_21095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L6176_21115	COG0095	Lipoate-protein ligase
L6176_21120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6176_21125	COG1609	Transcriptional regulator
L6176_21135	COG2076	Multidrug Resistance protein
L6176_21140	COG2076	Multidrug Resistance protein
L6176_21180	COG1725	Transcriptional regulator
L6176_21210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6176_21265	COG4970	Tfp pilus assembly protein FimT
L6176_21275	COG1459	type II secretion system
L6176_21280	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L6176_21330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L6176_21335	COG0646	methionine synthase
L6176_21335	COG1410	methionine synthase
L6176_21340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L6176_21340	COG0646	methionine synthase
L6176_21345	COG0626	cystathionine gamma-synthase activity
L6176_21350	COG0626	cystathionine gamma-synthase activity
L6176_21370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_21380	COG1940	carbohydrate kinase activity
L6176_21385	COG4483	Protein conserved in bacteria
L6176_21390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L6176_21395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L6176_21400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L6176_21405	COG0704	Plays a role in the regulation of phosphate uptake
L6176_21415	COG0581	inorganic phosphate transmembrane transporter activity
L6176_21420	COG0573	inorganic phosphate transmembrane transporter activity
L6176_21425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L6176_21430	COG0768	penicillin binding
L6176_21435	COG0477	Major facilitator Superfamily
L6176_21440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6176_21465	COG0735	belongs to the Fur family
L6176_21470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L6176_21475	COG1121	(ABC) transporter
L6176_21480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_21510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6176_21515	COG2384	SAM-dependent methyltransferase
L6176_21520	COG2010	Cytochrome c
L6176_21525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L6176_21530	COG0358	DNA primase activity
L6176_21540	COG0517	IMP dehydrogenase activity
L6176_21555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L6176_21560	COG0295	cytidine deaminase activity
L6176_21565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L6176_21580	COG1702	phosphate starvation-inducible protein PhoH
L6176_21595	COG1610	YqeY-like protein
L6176_21600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L6176_21605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L6176_21610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L6176_21640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L6176_21645	COG1733	regulation of RNA biosynthetic process
L6176_21670	COG1466	dna polymerase III delta subunit
L6176_21680	COG2333	competence protein COMEC
L6176_21680	COG0658	competence protein
L6176_21685	COG2131	deaminase
L6176_21690	COG1555	photosystem II stabilization
L6176_21690	COG1596	polysaccharide export
L6176_21695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L6176_21700	COG2226	methyltransferase
L6176_21705	COG0799	negative regulation of ribosome biogenesis
L6176_21710	COG1713	HD superfamily hydrolase involved in NAD metabolism
L6176_21720	COG1534	Rna-binding protein
L6176_21730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L6176_21735	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L6176_21760	COG1595	DNA-templated transcription, initiation
L6176_21770	COG0778	Nitroreductase
L6176_21775	COG2357	RelA SpoT domain protein
L6176_21785	COG1785	Belongs to the alkaline phosphatase family
L6176_21795	COG2267	carboxylic ester hydrolase activity
L6176_21830	COG1404	Belongs to the peptidase S8 family
L6176_21835	COG3186	Phenylalanine-4-hydroxylase
L6176_21850	COG2259	Doxx family
L6176_21890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_21900	COG1012	belongs to the aldehyde dehydrogenase family
L6176_21900	COG1454	alcohol dehydrogenase
L6176_21905	COG0626	cystathionine gamma-synthase activity
L6176_21910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L6176_21935	COG0768	penicillin binding
L6176_21950	COG0826	peptidase U32
L6176_21955	COG0826	peptidase U32
L6176_21960	COG4122	O-methyltransferase activity
L6176_21965	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L6176_21985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L6176_21995	COG0628	permease
L6176_22015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L6176_22025	COG0482	sulfurtransferase activity
L6176_22030	COG1104	cysteine desulfurase activity
L6176_22035	COG1959	2 iron, 2 sulfur cluster binding
L6176_22040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L6176_22050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L6176_22075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L6176_22085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L6176_22085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L6176_22090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L6176_22095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6176_22095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L6176_22105	COG2244	polysaccharide biosynthetic process
L6176_22110	COG2323	membrane
L6176_22120	COG1862	Preprotein translocase
L6176_22150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L6176_22160	COG0697	spore germination
L6176_22165	COG0697	spore germination
L6176_22170	COG0640	Transcriptional regulator
L6176_22195	COG0157	Belongs to the NadC ModD family
L6176_22200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L6176_22205	COG1104	cysteine desulfurase activity
L6176_22210	COG1827	regulation of RNA biosynthetic process
L6176_22215	COG2258	MOSC domain
L6176_22220	COG0077	Prephenate dehydratase
L6176_22225	COG0577	efflux transmembrane transporter activity
L6176_22230	COG0577	efflux transmembrane transporter activity
L6176_22235	COG1136	(ABC) transporter
L6176_22245	COG0745	RESPONSE REGULATOR receiver
L6176_22250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L6176_22255	COG3290	protein histidine kinase activity
L6176_22265	COG2868	ribosomal protein
L6176_22275	COG1530	ribonuclease E activity
L6176_22280	COG1994	Peptidase M50
L6176_22285	COG0739	heme binding
L6176_22290	COG2894	cell division
L6176_22310	COG1077	Cell shape determining protein MreB Mrl
L6176_22330	COG0285	dihydrofolate synthase activity
L6176_22335	COG0525	valine-tRNA ligase activity
L6176_22345	COG1388	LysM domain
L6176_22355	COG0113	porphobilinogen synthase activity
L6176_22360	COG1587	Uroporphyrinogen-III synthase
L6176_22370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L6176_22380	COG1846	Transcriptional regulator
L6176_22385	COG1764	response to oxidative stress
L6176_22400	COG0470	DNA polymerase III
L6176_22400	COG1067	ATP-dependent peptidase activity
L6176_22445	COG0622	Phosphoesterase
L6176_22460	COG5401	PFAM Sporulation and spore germination
L6176_22480	COG1309	transcriptional regulator
L6176_22495	COG2197	response regulator
L6176_22500	COG2233	PERMEase
L6176_22510	COG0402	S-adenosylhomocysteine deaminase activity
L6176_22515	COG0402	S-adenosylhomocysteine deaminase activity
L6176_22525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L6176_22535	COG0444	Belongs to the ABC transporter superfamily
L6176_22540	COG4608	Belongs to the ABC transporter superfamily
L6176_22545	COG3275	phosphorelay sensor kinase activity
L6176_22550	COG3279	Response regulator of the LytR AlgR family
L6176_22565	COG1983	PspC domain protein
L6176_22570	COG1396	sequence-specific DNA binding
L6176_22575	COG0697	spore germination
L6176_22585	COG1959	2 iron, 2 sulfur cluster binding
L6176_22590	COG1668	transmembrane transport
L6176_22595	COG4152	abc transporter atp-binding protein
L6176_22600	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L6176_22610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L6176_22615	COG1876	peptidase activity
L6176_22620	COG0824	Thioesterase
L6176_22625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L6176_22630	COG1053	succinate dehydrogenase
L6176_22635	COG2009	succinate dehydrogenase
L6176_22640	COG1719	4-vinyl reductase, 4VR
L6176_22650	COG3118	belongs to the thioredoxin family
L6176_22655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L6176_22660	COG2086	electron transfer activity
L6176_22665	COG1024	Enoyl-CoA hydratase
L6176_22675	COG0318	PFAM AMP-dependent synthetase and ligase
L6176_22695	COG2318	DinB family
L6176_22725	COG1131	(ABC) transporter
L6176_22730	COG2205	protein histidine kinase activity
L6176_22735	COG0745	RESPONSE REGULATOR receiver
L6176_22745	COG4895	conserved protein (DUF2196)
L6176_22750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L6176_22765	COG4509	Sortase family
L6176_22770	COG1120	ATPase activity
L6176_22785	COG5386	Cell surface protein
L6176_22795	COG5386	Cell surface protein
L6176_22800	COG1114	Component of the transport system for branched-chain amino acids
L6176_22805	COG1187	pseudouridine synthase activity
L6176_22815	COG1796	DNA polymerase
L6176_22815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L6176_22820	COG1286	toxin biosynthetic process
L6176_22865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L6176_22875	COG1418	mRNA catabolic process
L6176_22900	COG2814	Major facilitator Superfamily
L6176_22905	COG1566	PFAM secretion protein HlyD family protein
L6176_22910	COG1309	transcriptional regulator
L6176_22915	COG1363	Peptidase, m42
L6176_22940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L6176_22950	COG1484	DNA-dependent DNA replication
L6176_22955	COG3611	Membrane attachment protein
L6176_22965	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6176_22970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6176_22975	COG0237	dephospho-CoA kinase activity
L6176_22980	COG1971	Probably functions as a manganese efflux pump
L6176_22990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6176_22990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L6176_22995	COG5002	protein histidine kinase activity
L6176_23000	COG0745	RESPONSE REGULATOR receiver
L6176_23020	COG0538	isocitrate dehydrogenase activity
L6176_23025	COG0372	Belongs to the citrate synthase family
L6176_23035	COG0628	permease
L6176_23040	COG3030	protein affecting phage T7 exclusion by the F plasmid
L6176_23065	COG1725	Transcriptional regulator
L6176_23070	COG0281	malic enzyme
L6176_23075	COG0587	DNA-directed DNA polymerase activity
L6176_23090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L6176_23110	COG4109	DRTGG domain
L6176_23125	COG0006	proline dipeptidase activity
L6176_23165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_23170	COG0662	Cupin 2, conserved barrel domain protein
L6176_23180	COG1476	TRANSCRIPTIONal
L6176_23195	COG1028	Short-chain dehydrogenase reductase Sdr
L6176_23200	COG0589	response to stress
L6176_23240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_23260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L6176_23265	COG0827	DNA restriction-modification system
L6176_23270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L6176_23275	COG3874	Sporulation protein YtfJ
L6176_23290	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L6176_23300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6176_23315	COG1104	cysteine desulfurase activity
L6176_23325	COG0583	DNA-binding transcription factor activity
L6176_23330	COG0697	spore germination
L6176_23340	COG1956	GAF domain-containing protein
L6176_23345	COG0626	cystathionine gamma-synthase activity
L6176_23375	COG1595	DNA-templated transcription, initiation
L6176_23385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L6176_23390	COG0454	-acetyltransferase
L6176_23395	COG0517	IMP dehydrogenase activity
L6176_23400	COG0123	including yeast histone deacetylase and acetoin utilization protein
L6176_23410	COG0745	RESPONSE REGULATOR receiver
L6176_23420	COG0666	response to abiotic stimulus
L6176_23455	COG1609	Transcriptional regulator
L6176_23460	COG4851	CamS sex pheromone cAM373 precursor
L6176_23465	COG3118	belongs to the thioredoxin family
L6176_23475	COG2309	aminopeptidase activity
L6176_23495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_23510	COG1674	ftsk spoiiie
L6176_23520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L6176_23525	COG4848	Belongs to the UPF0354 family
L6176_23530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6176_23535	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
L6176_23540	COG1363	Peptidase, m42
L6176_23550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_23565	COG0510	thiamine kinase activity
L6176_23570	COG1523	belongs to the glycosyl hydrolase 13 family
L6176_23585	COG1349	DNA-binding transcription factor activity
L6176_23590	COG1187	pseudouridine synthase activity
L6176_23595	COG2244	polysaccharide biosynthetic process
L6176_23600	COG2081	HI0933 family
L6176_23605	COG2814	Major facilitator Superfamily
L6176_23615	COG3832	glyoxalase III activity
L6176_23635	COG1329	Transcriptional regulator
L6176_23645	COG4975	Glucose uptake
L6176_23660	COG0314	molybdopterin synthase activity
L6176_23665	COG1763	Mo-molybdopterin cofactor biosynthetic process
L6176_23670	COG0303	'Molybdopterin
L6176_23680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L6176_23705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L6176_23715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L6176_23755	COG2814	Major facilitator Superfamily
L6176_23760	COG0475	glutathione-regulated potassium exporter activity
L6176_23765	COG0490	domain, Protein
L6176_23770	COG0582	viral genome integration into host DNA
L6176_23780	COG1136	(ABC) transporter
L6176_23800	COG1242	4 iron, 4 sulfur cluster binding
L6176_23805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L6176_23810	COG1131	(ABC) transporter
L6176_23820	COG1794	racemase activity, acting on amino acids and derivatives
L6176_23840	COG2267	carboxylic ester hydrolase activity
L6176_23845	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L6176_23850	COG0671	phosphoesterase, PA-phosphatase related
L6176_23855	COG0438	transferase activity, transferring glycosyl groups
L6176_23865	COG0521	Mo-molybdopterin cofactor biosynthetic process
L6176_23920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L6176_23925	COG5002	protein histidine kinase activity
L6176_23930	COG4191	Histidine kinase
L6176_23935	COG2267	carboxylic ester hydrolase activity
L6176_23955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L6176_23960	COG1116	anion transmembrane transporter activity
L6176_23965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L6176_23990	COG0494	nUDIX hydrolase
L6176_24025	COG0288	reversible hydration of carbon dioxide
L6176_24030	COG1271	oxidase subunit
L6176_24035	COG1294	oxidase, subunit
L6176_24055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_24080	COG1842	Phage shock protein A
L6176_24110	COG5002	protein histidine kinase activity
L6176_24115	COG0745	RESPONSE REGULATOR receiver
L6176_24145	COG1597	lipid kinase activity
L6176_24180	COG0586	Pfam SNARE associated Golgi protein
L6176_24190	COG0577	efflux transmembrane transporter activity
L6176_24195	COG1136	(ABC) transporter
L6176_24200	COG3708	Transcriptional regulator
L6176_24200	COG2207	Transcriptional regulator
L6176_24205	COG0745	RESPONSE REGULATOR receiver
L6176_24210	COG2205	protein histidine kinase activity
L6176_24220	COG0577	efflux transmembrane transporter activity
L6176_24225	COG1136	(ABC) transporter
L6176_24245	COG2188	Transcriptional regulator
L6176_24265	COG3964	amidohydrolase
L6176_24295	COG4948	Mandelate Racemase Muconate Lactonizing
L6176_24305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L6176_24310	COG0596	Alpha beta hydrolase
L6176_24315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L6176_24320	COG1169	isochorismate synthase
L6176_24325	COG1575	Belongs to the MenA family. Type 1 subfamily
L6176_24330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L6176_24350	COG0058	SHG alpha-glucan phosphorylase activity
L6176_24355	COG0297	glycogen (starch) synthase activity
L6176_24360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L6176_24475	COG0544	peptidyl-prolyl cis-trans isomerase activity
L6176_24510	COG1285	pathogenesis
L6176_24515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6176_24525	COG0166	Belongs to the GPI family
L6176_24530	COG2155	Conserved Protein
L6176_24535	COG1098	S1 RNA binding domain
L6176_24540	COG0436	Aminotransferase
L6176_24545	COG1522	sequence-specific DNA binding
L6176_24550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L6176_24555	COG2267	carboxylic ester hydrolase activity
L6176_24565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L6176_24585	COG5018	Exonuclease
L6176_24590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6176_24610	COG2050	protein possibly involved in aromatic compounds catabolism
L6176_24620	COG1268	BioY protein
L6176_24630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L6176_24635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L6176_24650	COG3584	3D domain protein
L6176_24665	COG1252	NADH dehydrogenase
L6176_24680	COG3708	Transcriptional regulator
L6176_24695	COG1683	Conserved Protein
L6176_24715	COG0316	Belongs to the HesB IscA family
L6176_24730	COG1252	NADH dehydrogenase
L6176_24745	COG0390	transport system, permease component
L6176_24750	COG2824	Alkylphosphonate utilization operon protein PhnA
L6176_24790	COG4837	Protein of unknown function (DUF1462)
L6176_24795	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
L6176_24805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L6176_24810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L6176_24820	COG2249	NAD(P)H dehydrogenase (quinone) activity
L6176_24825	COG0647	UMP catabolic process
L6176_24835	COG2445	Protein of unknown function DUF86
L6176_24840	COG1494	fructose-1,6-bisphosphatase
L6176_24855	COG4470	Protein conserved in bacteria
L6176_24865	COG0789	Transcriptional regulator
L6176_24870	COG4377	Putative membrane peptidase family (DUF2324)
L6176_24895	COG0739	heme binding
L6176_24905	COG3377	Domain of unknown function (DUF1805)
L6176_24910	COG0737	Belongs to the 5'-nucleotidase family
L6176_24915	COG1695	Transcriptional regulator
L6176_24925	COG0719	Fe-S assembly protein
L6176_24930	COG0822	iron-sulfur transferase activity
L6176_24935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L6176_24940	COG0719	Fe-S assembly protein
L6176_24945	COG0396	ATPase activity
L6176_24950	COG1464	Belongs to the NlpA lipoprotein family
L6176_24955	COG1464	Belongs to the NlpA lipoprotein family
L6176_24960	COG2011	ABC-type metal ion transport system permease component
L6176_24965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L6176_24975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L6176_24980	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L6176_24990	COG1393	Belongs to the ArsC family
L6176_25035	COG0039	L-malate dehydrogenase activity
L6176_25060	COG1309	transcriptional regulator
L6176_25065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L6176_25070	COG1960	acyl-CoA dehydrogenase activity
L6176_25075	COG0183	Belongs to the thiolase family
L6176_25080	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6176_25080	COG1024	Enoyl-CoA hydratase
L6176_25090	COG1686	Belongs to the peptidase S11 family
L6176_25105	COG0011	TIGRFAM Protein of
L6176_25110	COG0840	transmembrane signaling receptor activity
L6176_25130	COG2814	Major facilitator Superfamily
L6176_25135	COG0531	amino acid
L6176_25145	COG0706	membrane insertase activity
L6176_25155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L6176_25190	COG0586	Pfam SNARE associated Golgi protein
L6176_25200	COG1376	ErfK ybiS ycfS ynhG family protein
L6176_25205	COG0745	RESPONSE REGULATOR receiver
L6176_25235	COG2151	metal-sulfur cluster biosynthetic enzyme
L6176_25240	COG3227	Zinc metalloprotease (Elastase)
L6176_25245	COG1741	Belongs to the pirin family
L6176_25260	COG0475	glutathione-regulated potassium exporter activity
L6176_25265	COG0490	domain, Protein
L6176_25270	COG1115	amino acid carrier protein
L6176_25275	COG0783	Belongs to the Dps family
L6176_25290	COG1611	Belongs to the LOG family
L6176_25310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_25315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_25320	COG1115	amino acid carrier protein
L6176_25325	COG1115	amino acid carrier protein
L6176_25330	COG2910	NAD(P)H-binding
L6176_25345	COG0656	L-ascorbic acid biosynthetic process
L6176_25350	COG2814	Major facilitator Superfamily
L6176_25355	COG1733	regulation of RNA biosynthetic process
L6176_25365	COG1252	NADH dehydrogenase
L6176_25370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L6176_25375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L6176_25385	COG3290	protein histidine kinase activity
L6176_25385	COG0840	transmembrane signaling receptor activity
L6176_25395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6176_25400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L6176_25415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L6176_25470	COG0557	exoribonuclease II activity
L6176_25475	COG1647	Serine aminopeptidase, S33
L6176_25480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L6176_25485	COG1346	cytolysis
L6176_25580	COG4695	Portal protein
L6176_25605	COG4974	Belongs to the 'phage' integrase family
L6176_25615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L6176_25620	COG0149	triose-phosphate isomerase activity
L6176_25630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L6176_25645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L6176_25670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L6176_25685	COG2323	membrane
L6176_25690	COG0740	serine-type endopeptidase activity
L6176_25695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L6176_25705	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L6176_25715	COG1051	belongs to the nudix hydrolase family
L6176_25725	COG0492	ferredoxin-NADP+ reductase activity
L6176_25730	COG0457	Tetratricopeptide repeat
L6176_25735	COG0110	maltose O-acetyltransferase activity
L6176_25755	COG1950	PFAM Membrane protein of
L6176_25765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L6176_25770	COG0556	nucleotide-excision repair
L6176_25790	COG0789	Transcriptional regulator
L6176_25815	COG2855	membrane
L6176_25820	COG0583	DNA-binding transcription factor activity
L6176_25830	COG0655	NAD(P)H dehydrogenase (quinone) activity
L6176_25835	COG0488	(ABC) transporter
L6176_25845	COG1132	(ABC) transporter
L6176_25850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6176_25855	COG0793	Belongs to the peptidase S41A family
L6176_25855	COG3409	Peptidoglycan-binding domain 1 protein
L6176_25860	COG2177	Part of the ABC transporter FtsEX involved in
L6176_25865	COG2884	Cell division ATP-binding protein ftsE
L6176_25880	COG0653	protein targeting
L6176_25885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L6176_25890	COG1278	Cold shock
L6176_25895	COG1040	competence protein
L6176_25900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L6176_25905	COG1388	LysM domain
L6176_25905	COG0791	NLP P60 protein
L6176_25910	COG1733	regulation of RNA biosynthetic process
L6176_25915	COG1307	EDD domain protein, DegV family
L6176_25920	COG1739	Uncharacterized protein family UPF0029
L6176_25925	COG1316	TRANSCRIPTIONal
L6176_25930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6176_25935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L6176_25940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L6176_25950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
L6176_25950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L6176_25965	COG3394	polysaccharide catabolic process
L6176_25970	COG1486	melibiose metabolic process
L6176_25975	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6176_25980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6176_25990	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L6176_25995	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L6176_26000	COG1447	Phosphotransferase system cellobiose-specific component IIA
L6176_26010	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L6176_26015	COG1301	dicarboxylic acid transport
L6176_26025	COG0346	lactoylglutathione lyase activity
L6176_26030	COG1511	domain protein
L6176_26035	COG0583	DNA-binding transcription factor activity
L6176_26040	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L6176_26055	COG1271	oxidase subunit
L6176_26060	COG1294	oxidase, subunit
L6176_26065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L6176_26075	COG1620	l-lactate permease
L6176_26085	COG2389	metal-binding protein
L6176_26095	COG1368	sulfuric ester hydrolase activity
L6176_26110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L6176_26120	COG1215	transferase activity, transferring glycosyl groups
L6176_26125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6176_26130	COG1388	LysM domain
L6176_26130	COG3584	3D domain protein
L6176_26155	COG4715	Zinc finger, swim domain protein
L6176_26160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L6176_26200	COG0577	efflux transmembrane transporter activity
L6176_26205	COG1136	(ABC) transporter
L6176_26240	COG5002	protein histidine kinase activity
L6176_26245	COG0745	RESPONSE REGULATOR receiver
L6176_26250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6176_26270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L6176_26275	COG1134	teichoic acid transport
L6176_26280	COG1682	transport, permease protein
L6176_26285	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L6176_26330	COG1609	Transcriptional regulator
L6176_26345	COG0739	heme binding
L6176_26365	COG2385	sporulation resulting in formation of a cellular spore
L6176_26380	COG4836	Membrane
L6176_26385	COG1007	ATP synthesis coupled electron transport
L6176_26390	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6176_26395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L6176_26405	COG0839	Belongs to the complex I subunit 6 family
L6176_26420	COG0649	NAD binding
L6176_26425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L6176_26440	COG3300	MHYT domain
L6176_26440	COG5001	Diguanylate cyclase
L6176_26490	COG0356	it plays a direct role in the translocation of protons across the membrane
L6176_26525	COG0698	ribose 5-phosphate isomerase
L6176_26535	COG2190	(PTS) system
L6176_26540	COG2259	Doxx family
L6176_26545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L6176_26560	COG0009	L-threonylcarbamoyladenylate synthase
L6176_26575	COG2890	protein-(glutamine-N5) methyltransferase activity
L6176_26595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L6176_26600	COG1494	fructose-1,6-bisphosphatase
L6176_26620	COG4821	SIS domain
L6176_26630	COG3343	RNA polymerase activity
L6176_26640	COG1960	acyl-CoA dehydrogenase activity
L6176_26645	COG1960	acyl-CoA dehydrogenase activity
L6176_26650	COG1250	3-hydroxyacyl-CoA dehydrogenase
L6176_26655	COG0183	Belongs to the thiolase family
L6176_26660	COG0247	lactate metabolic process
L6176_26660	COG2181	nitrate reductase activity
L6176_26665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L6176_26675	COG5001	Diguanylate cyclase
L6176_26675	COG3300	MHYT domain
L6176_26695	COG2197	response regulator
L6176_26700	COG4585	Histidine kinase
L6176_26705	COG0842	Transport permease protein
L6176_26710	COG1131	(ABC) transporter
L6176_26715	COG0024	Methionine aminopeptidase
L6176_26725	COG2234	aminopeptidase activity
L6176_26745	COG1595	DNA-templated transcription, initiation
L6176_26750	COG0018	arginyl-trna synthetase
L6176_26755	COG4506	Protein conserved in bacteria
L6176_26760	COG1619	proteins homologs of microcin C7 resistance protein MccF
L6176_26775	COG0010	Belongs to the arginase family
L6176_26785	COG2814	Major facilitator Superfamily
L6176_26790	COG0789	Transcriptional regulator
L6176_26795	COG0584	glycerophosphoryl diester phosphodiesterase
L6176_26800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L6176_26810	COG1994	Peptidase M50
L6176_26820	COG1078	dGTPase activity
L6176_26825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L6176_26830	COG1120	ATPase activity
L6176_26835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L6176_26860	COG0095	Lipoate-protein ligase
L6176_26865	COG0280	phosphate acetyltransferase
L6176_26880	COG3773	Cell wall hydrolase
L6176_26890	COG2363	Small membrane protein
L6176_26900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L6176_26905	COG2233	PERMEase
L6176_26910	COG0561	phosphatase activity
L6176_26915	COG2814	Major facilitator Superfamily
L6176_26925	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L6176_26930	COG1131	(ABC) transporter
L6176_26935	COG2755	lipolytic protein G-D-S-L family
L6176_26940	COG1609	Transcriptional regulator
L6176_26950	COG0460	homoserine dehydrogenase
L6176_26960	COG2873	o-acetylhomoserine
L6176_26970	COG1011	Hydrolase
L6176_26975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L6176_26985	COG2197	response regulator
L6176_26995	COG0351	phosphomethylpyrimidine kinase
L6176_27000	COG3706	GGDEF domain
L6176_27005	COG2879	small protein
L6176_27010	COG1966	Carbon starvation protein
L6176_27015	COG3279	Response regulator of the LytR AlgR family
L6176_27020	COG0477	Major facilitator Superfamily
L6176_27045	COG0840	transmembrane signaling receptor activity
L6176_27055	COG1607	acyl-coa hydrolase
L6176_27070	COG0488	(ABC) transporter
L6176_27090	COG0463	Glycosyl transferase, family 2
L6176_27095	COG1309	transcriptional regulator
L6176_27100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L6176_27105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6176_27105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L6176_27110	COG0628	permease
L6176_27125	COG3279	Response regulator of the LytR AlgR family
L6176_27130	COG3275	phosphorelay sensor kinase activity
L6176_27135	COG2814	Major facilitator Superfamily
L6176_27140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L6176_27145	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L6176_27150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L6176_27170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L6176_27175	COG1272	protein, Hemolysin III
L6176_27195	COG0516	GMP reductase activity
L6176_27200	COG1164	Oligoendopeptidase f
L6176_27220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L6176_27225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L6176_27230	COG4853	Protein conserved in bacteria
L6176_27235	COG4863	YycH protein
L6176_27240	COG5002	protein histidine kinase activity
L6176_27245	COG0745	RESPONSE REGULATOR receiver
L6176_27275	COG0305	Participates in initiation and elongation during chromosome replication
L6176_27285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L6176_27290	COG4241	membrane
L6176_27300	COG0629	single-stranded DNA binding
L6176_27310	COG0012	GTP binding
L6176_27315	COG4481	Protein conserved in bacteria
L6176_27320	COG0668	transmembrane transport
L6176_27330	COG1475	DNA binding
L6176_27335	COG1192	Involved in chromosome partitioning
L6176_27360	COG1847	R3H domain protein
L6176_27365	COG0706	membrane insertase activity
L6176_27375	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L6176_27410	COG0791	NLP P60 protein
L6176_27410	COG0741	lytic transglycosylase activity
L6176_27565	COG1192	Involved in chromosome partitioning
L6176_27610	COG1683	Conserved Protein
L6176_27615	COG1309	transcriptional regulator
L6176_27690	COG0681	Belongs to the peptidase S26 family
L6176_27715	COG1280	lysine exporter protein (LysE YggA)
L6176_27760	COG4166	transmembrane transport
L6176_27770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII