locus-tag class description AOD59_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD59_00015 ENOG410848D S4 domain protein YaaA AOD59_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD59_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AOD59_00100 ENOG4105ZMH deoxynucleoside kinase AOD59_00110 ENOG4105GTG Isochorismatase AOD59_00120 ENOG4108Z6B deaminase AOD59_00125 ENOG4105C6E dna polymerase iii AOD59_00145 ENOG41067KS pro-sigma K processing AOD59_00180 ENOG4105CXN decarboxylase AOD59_00190 ENOG4105FA2 dna polymerase iii AOD59_00195 ENOG4105MA4 psp1 domain protein AOD59_00205 ENOG41060K3 Methyltransferase AOD59_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AOD59_00220 ENOG4105KRN Transcriptional regulator, abrb family AOD59_00230 ENOG4105F8V Hydrolase, tatD family AOD59_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AOD59_00245 ENOG4105XFA sporulation peptidase YabG AOD59_00250 ENOG4105W42 Veg protein AOD59_00265 ENOG4105DFT pur operon repressor AOD59_00270 ENOG4105KME endoribonuclease L-psp AOD59_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AOD59_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AOD59_00300 ENOG4108JA2 transcriptioN-repair coupling factor AOD59_00305 ENOG4108M14 stage v sporulation protein t AOD59_00315 ENOG4108IY2 MazG family AOD59_00320 ENOG41082I2 s4 domain protein AOD59_00325 ENOG4105VYY sporulation protein yabp AOD59_00340 ENOG41060GV RNA binding s1 domain protein AOD59_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AOD59_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD59_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AOD59_00385 ENOG4105C6T cysteine synthase AOD59_00390 ENOG4105CRQ synthase (Component I) AOD59_00395 ENOG4105DDQ anthranilate synthase AOD59_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AOD59_00405 ENOG4105EEI dihydropteroate synthase AOD59_00410 ENOG4105KRF dihydroneopterin aldolase AOD59_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AOD59_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AOD59_00455 ENOG4108Z0C Uvrb UvrC protein AOD59_00470 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AOD59_00480 ENOG4105CTP PilT protein domain protein AOD59_00500 ENOG4105D7W serine acetyltransferase AOD59_00515 ENOG4105C2N RNA methyltransferase TrmH family group 3 AOD59_00520 ENOG4105M0M Tetracycline resistance protein AOD59_00525 ENOG4105QIV RNA polymerase AOD59_00540 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AOD59_00565 ENOG4107Y49 methyltransferase AOD59_00575 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AOD59_00580 ENOG4105XPM ribosomal protein AOD59_00685 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AOD59_00710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD59_00720 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD59_00730 ENOG41067V7 50S ribosomal protein L36 AOD59_00760 ENOG4108JJB ABC transporter AOD59_00765 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD59_00770 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD59_00795 ENOG4105D1F ATP-binding protein AOD59_00810 ENOG4108NMV polysaccharide deacetylase AOD59_00895 ENOG4105C8B TIGR00159 family AOD59_00900 ENOG4107U5W ybbr family AOD59_00915 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AOD59_00920 ENOG4108VQT Alpha beta hydrolase fold protein AOD59_00940 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AOD59_00945 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AOD59_00980 ENOG4108PSK reductase AOD59_00985 ENOG4108UMI ABC transporter, permease AOD59_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD59_00995 ENOG4105D01 (LipO)protein AOD59_01000 ENOG4105EE1 crotonyl-CoA reductase AOD59_01010 ENOG4105IQ5 FAD linked oxidase domain protein AOD59_01025 ENOG4105C2C drug resistance transporter, Bcr CflA AOD59_01040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD59_01045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD59_01050 ENOG4105C3U ABC transporter AOD59_01055 ENOG4108JQ7 (ABC) transporter AOD59_01085 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD59_01090 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD59_01100 ENOG4105II7 pyrroline-5-carboxylate reductase AOD59_01110 ENOG4107XDY Nicotinamide Mononucleotide Transporter AOD59_01120 ENOG4105E0C molybdate abc transporter AOD59_01125 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD59_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD59_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AOD59_01150 ENOG4105EGI Transcriptional regulator AOD59_01165 ENOG4105F6E Acyl-transferase AOD59_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD59_01200 ENOG4108RE7 deoxyribonuclease AOD59_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AOD59_01230 ENOG4105C5H ABC transporter AOD59_01245 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AOD59_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD59_01260 ENOG4105C3U ABC transporter AOD59_01265 ENOG4108JQ7 (ABC) transporter AOD59_01290 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AOD59_01295 ENOG4105ERH Fumarylacetoacetate hydrolase AOD59_01305 ENOG4108SC4 )-transporter AOD59_01310 ENOG4105CPF Cell wall formation (By similarity) AOD59_01315 ENOG4105CPF Cell wall formation (By similarity) AOD59_01320 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD59_01335 ENOG4107ZXI Rhomboid family AOD59_01345 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AOD59_01350 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD59_01360 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AOD59_01460 ENOG4105K8N protein family UPF0079, ATPase AOD59_01465 ENOG41072GX Peptidase M22 Glycoprotease AOD59_01470 ENOG410801F ribosomal-protein-alanine acetyltransferase AOD59_01475 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD59_01480 ENOG4105C5H ABC transporter AOD59_01495 ENOG4108TYN CAAX amino terminal protease family protein AOD59_01515 ENOG4105C7N Xanthine uracil vitamin C permease AOD59_01525 ENOG4105BZU Histidine kinase AOD59_01555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD59_01595 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD59_01615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AOD59_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AOD59_01645 ENOG4105C83 adenylosuccinate lyase AOD59_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AOD59_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase AOD59_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase AOD59_01715 ENOG4105C4R Atp-dependent dna helicase AOD59_01745 ENOG4108W2Y isochorismatase AOD59_01750 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD59_01755 ENOG4108UMI ABC transporter, permease AOD59_01760 ENOG4105D01 (LipO)protein AOD59_01780 ENOG410834F Transcriptional regulator AOD59_01805 ENOG4105CBD Diacylglycerol kinase AOD59_01810 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AOD59_01815 ENOG4108JPW Aminotransferase AOD59_01825 ENOG4105C26 Dehydrogenase AOD59_01830 ENOG4105KPY Small multidrug resistance protein AOD59_01850 ENOG4105D9N nucleoside AOD59_01855 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD59_01870 ENOG4108W15 Protein of unknown function (DUF1456) AOD59_01885 ENOG4105DTQ mandelate racemase muconate lactonizing AOD59_01895 ENOG4105DFD Na H antiporter AOD59_01915 ENOG4105D3R alkyl hydroperoxide reductase AOD59_01920 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AOD59_01930 ENOG4107W7X Aldolase AOD59_01935 ENOG4105EHG Permease protein AOD59_01940 ENOG4105DQ5 transport system permease protein AOD59_01945 ENOG4108V5C ABC transporter AOD59_01970 ENOG4106UIA AOD59_01975 ENOG4106UIA AOD59_02000 ENOG4105BZU Histidine kinase AOD59_02020 ENOG410756H nucleotidyltransferase AOD59_02025 ENOG4105D2S major facilitator superfamily AOD59_02040 ENOG4105E5Q amino acid AbC transporter AOD59_02045 ENOG4105EAB amino acid AbC transporter AOD59_02060 ENOG4105C8Q Methyl-accepting chemotaxis AOD59_02065 ENOG4105C8Q Methyl-accepting chemotaxis AOD59_02075 ENOG4105CI1 PTS System AOD59_02105 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AOD59_02120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD59_02135 ENOG4105C5H ABC transporter AOD59_02160 ENOG41062JF Transcriptional regulator AOD59_02180 ENOG4105DEU major facilitator superfamily AOD59_02195 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) AOD59_02210 ENOG4108N0M stress protein AOD59_02215 ENOG4106FN3 tellurium resistance protein AOD59_02220 ENOG4106FN3 tellurium resistance protein AOD59_02225 ENOG4107TS3 membrane protein, TerC AOD59_02230 ENOG4108TTB tellurium resistance protein AOD59_02250 ENOG4105KJF protein tyrosine phosphatase AOD59_02260 ENOG4107U9T Pfam:Ribonuclease_BN AOD59_02265 ENOG4105C59 p-type ATPase AOD59_02270 ENOG4108IPJ Membrane AOD59_02290 ENOG4107ZTW SNARE associated Golgi AOD59_02305 ENOG410606W general stress protein AOD59_02310 ENOG4105UPD Calcium Proton AOD59_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AOD59_02355 ENOG4105VTR Integrase AOD59_02360 ENOG4108IMY Transcriptional regulator AOD59_02635 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AOD59_02645 ENOG4108JUB Transcriptional regulator AOD59_02655 ENOG4108IQI permease AOD59_02690 ENOG4105CSV Glutaminase AOD59_02700 ENOG4108A04 Beta-lactamase AOD59_02715 ENOG4105CKK Glycosyl transferase, family 2 AOD59_02725 ENOG4107QQG Dehydrogenase AOD59_02730 ENOG4105C3I Nad-dependent epimerase dehydratase AOD59_02750 ENOG4105F1A Pyruvate formate-lyase AOD59_02770 ENOG4105CI2 imidazolone-5-propionate hydrolase AOD59_02775 ENOG4105ECP epimerase AOD59_02805 ENOG41067AE Membrane-bound metal-dependent hydrolase AOD59_02810 ENOG4105CEN a g-specific adenine glycosylase AOD59_02815 ENOG4106BXE AOD59_02835 ENOG4105BZ1 (ABC) transporter AOD59_02840 ENOG4107NBY Membrane AOD59_02845 ENOG4105CBC glutamate synthase AOD59_02855 ENOG4108IUW ABC transporter AOD59_02875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD59_02880 ENOG4105G5W regulator Fur family AOD59_02995 ENOG4108JQC penicillin-binding protein 1A AOD59_03000 ENOG4107ZQN disulfide bond AOD59_03010 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AOD59_03020 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AOD59_03025 ENOG4105BZU Histidine kinase AOD59_03035 ENOG4105CYN Serine protein kinase AOD59_03060 ENOG4105C94 Transporter AOD59_03075 ENOG4105DZ6 Band 7 protein AOD59_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AOD59_03095 ENOG4105D4T Citrate transporter AOD59_03115 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD59_03120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD59_03125 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AOD59_03130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AOD59_03135 ENOG4105BZ7 extracellular solute-binding protein family 1 AOD59_03140 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AOD59_03145 ENOG4108STX response regulator AOD59_03150 ENOG4105US7 Histidine kinase AOD59_03175 ENOG4108MRH transcriptional regulatory protein AOD59_03185 ENOG4105C6K Malic enzyme AOD59_03195 ENOG4108UZ3 Transporter AOD59_03200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD59_03210 ENOG4105BZU Histidine kinase AOD59_03215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_03225 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD59_03230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD59_03235 ENOG4108JB9 formate dehydrogenase AOD59_03255 ENOG4105CUB amino acid AOD59_03265 ENOG4105C59 p-type ATPase AOD59_03270 ENOG4105DAP Nicotinate phosphoribosyltransferase AOD59_03300 ENOG41073R8 VanW family AOD59_03305 ENOG4108KGH TRANSCRIPTIONal AOD59_03310 ENOG4105D9N nucleoside AOD59_03315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AOD59_03320 ENOG4105C37 (CBS) domain AOD59_03325 ENOG4108IJ0 Aspartate ammonia-lyase AOD59_03330 ENOG4105DAA L-lactate AOD59_03345 ENOG4105DUX Transporter AOD59_03350 ENOG4108MES Periplasmic binding protein AOD59_03355 ENOG4105DQ5 transport system permease protein AOD59_03360 ENOG4108IHU transport system permease protein AOD59_03365 ENOG4105E0A ABC, transporter AOD59_03370 ENOG4105DMQ Methyltransferase AOD59_03390 ENOG4107T89 von Willebrand factor, type A AOD59_03395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AOD59_03400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD59_03415 ENOG4105BZU Histidine kinase AOD59_03420 ENOG4105D5Q Arginine ornithine antiporter AOD59_03425 ENOG4107414 GntR family transcriptional regulator AOD59_03430 ENOG4105C5Y PTS System AOD59_03435 ENOG4105CG3 alpha amylase, catalytic region AOD59_03450 ENOG4105E1K spore germination protein AOD59_03460 ENOG4105CRN Aminoglycoside phosphotransferase AOD59_03465 ENOG4105BZG amino acid carrier protein AOD59_03470 ENOG4105CDA abc transporter atp-binding protein AOD59_03475 ENOG4105CT1 (ABC) transporter AOD59_03480 ENOG4105EAD ABC transporter AOD59_03485 ENOG4105DRP amino acid AbC transporter AOD59_03490 ENOG4108IQI permease AOD59_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein AOD59_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein AOD59_03525 ENOG4105BZU Histidine kinase AOD59_03540 ENOG4105CHH sulfate transporter AOD59_03545 ENOG41068KF Universal stress protein AOD59_03555 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD59_03565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD59_03570 ENOG4108JQ7 (ABC) transporter AOD59_03575 ENOG4105C3U ABC transporter AOD59_03580 ENOG4105CXY transporter AOD59_03585 ENOG41067TZ transcriptional regulator, MarR family AOD59_03590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_03595 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_03600 ENOG4105ETE Transcriptional regulator (LacI family AOD59_03605 ENOG4108RVA ribokinase AOD59_03615 ENOG4105C2J ABC transporter AOD59_03620 ENOG4105CNN ABC, transporter AOD59_03625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AOD59_03630 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD59_03690 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD59_03695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD59_03700 ENOG41069ER domain protein AOD59_03705 ENOG4105VZ8 Transcriptional regulator AOD59_03710 ENOG4107D63 AOD59_03720 ENOG4105DUX Transporter AOD59_03740 ENOG4105C85 amino acid AOD59_03745 ENOG4105C7N Xanthine uracil vitamin C permease AOD59_03785 ENOG4105BZ9 Cytochrome C oxidase, subunit I AOD59_03790 ENOG4105E2S oxidase) subunit II AOD59_03795 ENOG4108IQI permease AOD59_03810 ENOG4106CAD Protein of unknown function (DUF3311) AOD59_03815 ENOG4105E1V na solute symporter AOD59_03830 ENOG4108NHD germination protein AOD59_03840 ENOG4105CE1 Ferrous iron transport protein b AOD59_03845 ENOG4105CE1 Ferrous iron transport protein b AOD59_03850 ENOG4105CE1 Ferrous iron transport protein b AOD59_03855 ENOG4105CVA phosphate AOD59_03860 ENOG4105C8U phosphate abc transporter AOD59_03865 ENOG4105E2Z phosphate ABC transporter (Permease AOD59_03990 ENOG41080XQ Signal transduction protein with cbs domains AOD59_04015 ENOG4105ETU transcriptional activator (TenA AOD59_04025 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AOD59_04035 ENOG4108VEU Thiamine monophosphate synthase AOD59_04040 ENOG41080HI glycine oxidase AOD59_04055 ENOG4105D06 uba thif-type nad fad binding protein AOD59_04060 ENOG4105DWF phosphomethylpyrimidine kinase AOD59_04110 ENOG4108INS Transcriptional regulator AOD59_04125 ENOG4105C7N Xanthine uracil vitamin C permease AOD59_04155 ENOG4105C5Y PTS System AOD59_04215 ENOG4107Y03 Nitroreductase AOD59_04220 ENOG4105ED1 spovr family AOD59_04245 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AOD59_04250 ENOG4105XTG Pfam:DUF156 AOD59_04255 ENOG4105VFE sira family AOD59_04260 ENOG4107TPS domain protein AOD59_04265 ENOG4105VFE sira family AOD59_04270 ENOG41085GJ domain protein AOD59_04280 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AOD59_04285 ENOG41087NI Sulfite exporter TauE/SafE AOD59_04295 ENOG4108KGH TRANSCRIPTIONal AOD59_04320 ENOG4105EMD TRANSCRIPTIONal AOD59_04325 ENOG4105VCP PTS System AOD59_04330 ENOG4105VZJ PTS System AOD59_04350 ENOG41069ER domain protein AOD59_04355 ENOG4107RBB ABC transporter, permease AOD59_04360 ENOG4105C19 ABC transporter AOD59_04390 ENOG4105WEF catalase AOD59_04425 ENOG4107T5V SNARE associated Golgi AOD59_04460 ENOG4105CUB amino acid AOD59_04465 ENOG4107RWR Sodium hydrogen exchanger AOD59_04475 ENOG4106KNT transcriptional regulator AOD59_04510 ENOG4108PCN EamA-like transporter family AOD59_04515 ENOG4108YXU transcriptional regulator AsnC family AOD59_04525 ENOG4105KPY Small multidrug resistance protein AOD59_04530 ENOG4105KPY Small multidrug resistance protein AOD59_04555 ENOG4105NF4 modulator of drug activity AOD59_04560 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD59_04565 ENOG4105E5W Transporter AOD59_04575 ENOG4107RKG DJ-1/PfpI family AOD59_04580 ENOG4105CH6 catalase AOD59_04590 ENOG4105D5Q Arginine ornithine antiporter AOD59_04595 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AOD59_04605 ENOG4105C26 Dehydrogenase AOD59_04615 ENOG4105BZ1 (ABC) transporter AOD59_04630 ENOG4105DRP amino acid AbC transporter AOD59_04635 ENOG4105CDA abc transporter atp-binding protein AOD59_04650 ENOG410839P AOD59_04685 ENOG4107FQX Alpha-acetolactate decarboxylase AOD59_04715 ENOG4105D4P Coproporphyrinogen iii oxidase AOD59_04730 ENOG4105CHH sulfate transporter AOD59_04770 ENOG4106AKK s-layer domain-containing protein AOD59_04780 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD59_04785 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD59_04800 ENOG4105CGU Enoyl-CoA hydratase AOD59_04820 ENOG4105DER m42 family AOD59_04840 ENOG4105CTU Proline racemase AOD59_04885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD59_04895 ENOG4108JQ7 (ABC) transporter AOD59_04925 ENOG4105CSH Transporter AOD59_04935 ENOG4108MRH transcriptional regulatory protein AOD59_04985 ENOG4105CDU Replicative dna helicase AOD59_05025 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_05075 ENOG4107P5I polyketide synthase AOD59_05080 ENOG4108IG5 Transcriptional regulator AOD59_05100 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD59_05120 ENOG4105CMT Dihydroxyacetone kinase AOD59_05135 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD59_05140 ENOG410847I Transcriptional regulator, BadM Rrf2 family AOD59_05165 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AOD59_05230 ENOG4105WN5 stage II sporulation protein AOD59_05240 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_05250 ENOG4108MJI response regulator AOD59_05255 ENOG4105BZU Histidine kinase AOD59_05260 ENOG4105BZU Histidine kinase AOD59_05285 ENOG4105K8R UPF0145 protein AOD59_05320 ENOG4107VRP DNA repair exonuclease AOD59_05325 ENOG4106D4I domain protein AOD59_05330 ENOG4105D7V transposase AOD59_05345 ENOG4108IND Tetr family transcriptional regulator AOD59_05350 ENOG4105EQ0 Major Facilitator superfamily AOD59_05370 ENOG4108MUZ hydrolase AOD59_05390 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AOD59_05405 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AOD59_05420 ENOG4105EMN RNA polymerase sigma factor AOD59_05445 ENOG4105C57 major facilitator superfamily AOD59_05450 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_05460 ENOG4105EEM helicase AOD59_05465 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD59_05495 ENOG4105K59 histidine triad (HIT) protein AOD59_05525 ENOG410905X membrane-flanked domain protein AOD59_05535 ENOG4105CKV Membrane AOD59_05575 ENOG410905X membrane-flanked domain protein AOD59_05580 ENOG4105CKV Membrane AOD59_05585 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AOD59_05590 ENOG4105BZ4 penicillin-binding protein AOD59_05595 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AOD59_05605 ENOG4105C1Q protoporphyrinogen oxidase AOD59_05630 ENOG4105NA0 Transcriptional regulator AOD59_05645 ENOG4105ECB domain protein AOD59_05675 ENOG4106AXD AOD59_05680 ENOG4108RQ5 Beta-lactamase domain-containing protein AOD59_05685 ENOG4105DF9 Lipoate-protein, ligase AOD59_05695 ENOG4105CEY Amp-dependent synthetase and ligase AOD59_05725 ENOG4105CNA YD repeat protein AOD59_05760 ENOG4105ENX hydrolase AOD59_05770 ENOG4107RN3 metallophosphoesterase AOD59_05775 ENOG4107TVP HD domain protein AOD59_05785 ENOG4108AEY RNA polymerase sigma factor AOD59_05790 ENOG41086D8 Transcriptional regulator AOD59_05810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_05835 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AOD59_05840 ENOG4105C8Q Methyl-accepting chemotaxis AOD59_05860 ENOG4105ZU5 s-layer protein AOD59_05865 ENOG4107QP3 malate synthase g AOD59_05880 ENOG4105VEQ Cold shock protein AOD59_05895 ENOG4105XVF Competence transcription factor AOD59_05910 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination AOD59_05915 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AOD59_05960 ENOG4105ERH Fumarylacetoacetate hydrolase AOD59_05985 ENOG4105CAQ asparagine synthetase AOD59_05990 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AOD59_05995 ENOG4105CH6 catalase AOD59_06000 ENOG4105BZU Histidine kinase AOD59_06025 ENOG4105QNR S1 RNA binding domain protein AOD59_06035 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD59_06045 ENOG4107AYK membrAne AOD59_06050 ENOG41073B9 AOD59_06060 ENOG4108KP7 hydrolase AOD59_06075 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AOD59_06100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD59_06105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AOD59_06120 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD59_06135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AOD59_06140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD59_06150 ENOG4108JQ7 (ABC) transporter AOD59_06155 ENOG4105UQX Mate efflux family protein AOD59_06180 ENOG4108ZCF integral membrane protein AOD59_06190 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD59_06200 ENOG4105DPN Oligoendopeptidase f AOD59_06215 ENOG4108Z18 K06886 hemoglobin AOD59_06220 ENOG4105MIX Adenylate cyclase AOD59_06235 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AOD59_06240 ENOG4105EMS pseudouridine synthase AOD59_06260 ENOG4105K64 Glycosyl transferase, family 2 AOD59_06280 ENOG4107TVC Glycosyl transferase, family 2 AOD59_06300 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AOD59_06305 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AOD59_06315 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AOD59_06365 ENOG4108WVJ 2'-5' rna ligase AOD59_06390 ENOG4105CK7 Sodium proline symporter AOD59_06400 ENOG4105CRQ synthase (Component I) AOD59_06405 ENOG4105DDQ anthranilate synthase AOD59_06495 ENOG4105C7S Dehydrogenase AOD59_06505 ENOG4105VZ8 Transcriptional regulator AOD59_06565 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AOD59_06575 ENOG4105DZ1 carboxypeptidase AOD59_06580 ENOG4105VFR signal peptidase AOD59_06615 ENOG4105C26 Dehydrogenase AOD59_06620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD59_06625 ENOG4105F38 ABC transporter, permease AOD59_06630 ENOG4105D38 putrescine abc transporter AOD59_06635 ENOG4107RUE extracellular solute-binding protein family 1 AOD59_06645 ENOG4105EYF MMPL domain protein AOD59_06655 ENOG4108YBP pseudouridine synthase AOD59_06665 ENOG4105K4I Scp-like extracellular AOD59_06670 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AOD59_06675 ENOG4105CQB FAD linked oxidase domain protein AOD59_06690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_06695 ENOG4105BZU Histidine kinase AOD59_06700 ENOG4105JXH GntR family transcriptional regulator AOD59_06720 ENOG4106A3R peptidase AOD59_06730 ENOG4108QTI )-transporter AOD59_06735 ENOG4107TS3 membrane protein, TerC AOD59_06740 ENOG4105CZN Potassium uptake protein AOD59_06745 ENOG410681C small acid-soluble spore protein AOD59_06750 ENOG4108Z7G MaoC domain protein dehydratase AOD59_06770 ENOG4105CHR reductase AOD59_06780 ENOG4105MWK D-amino acid dehydrogenase, small subunit AOD59_06800 ENOG4105C4Y ABC transporter AOD59_06815 ENOG4107RCV ABC transporter, permease AOD59_06820 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AOD59_06835 ENOG4105E98 transcriptional regulator DeoR family AOD59_06860 ENOG4105PXI polysaccharide deacetylase AOD59_06870 ENOG4105BZU Histidine kinase AOD59_06875 ENOG41090MY MarR family Transcriptional regulator AOD59_06885 ENOG4106DF1 AOD59_06895 ENOG4105BZU Histidine kinase AOD59_06905 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AOD59_06910 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AOD59_06955 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AOD59_06975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AOD59_06980 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD59_06985 ENOG4105CZV ABC transporter AOD59_06995 ENOG4105CJ1 ABC, transporter AOD59_07035 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD59_07040 ENOG4105EA8 2-Nitropropane dioxygenase AOD59_07045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD59_07055 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AOD59_07080 ENOG4105NQC Flavodoxin AOD59_07115 ENOG4107QMU Mate efflux family protein AOD59_07120 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AOD59_07150 ENOG4105CZN Potassium uptake protein AOD59_07155 ENOG41063Y9 AOD59_07160 ENOG4105KBJ sporulation protein ytfj AOD59_07190 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD59_07195 ENOG4105C7K acetolactate synthase AOD59_07200 ENOG4108ZP8 Acetolactate synthase small subunit AOD59_07205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD59_07215 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AOD59_07240 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AOD59_07275 ENOG4107RVV histidinol phosphate phosphatase, hisj family AOD59_07290 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AOD59_07295 ENOG4105E0M Sulfatase AOD59_07305 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AOD59_07325 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AOD59_07330 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AOD59_07340 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD59_07345 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD59_07350 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD59_07360 ENOG4105C8J )-transporter AOD59_07380 ENOG4105DFD Na H antiporter AOD59_07400 ENOG4105ENE Histidine kinase AOD59_07405 ENOG4105WH1 Two component transcriptional regulator luxr family AOD59_07425 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AOD59_07450 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AOD59_07475 ENOG4105CJ3 phosphate transporter AOD59_07480 ENOG4107GRR phosphate transport regulator AOD59_07485 ENOG4105BZ4 penicillin-binding protein AOD59_07500 ENOG4105BZU Histidine kinase AOD59_07505 ENOG4105I3N Conserved Protein AOD59_07520 ENOG4105BZU Histidine kinase AOD59_07555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD59_07560 ENOG4105DZ1 carboxypeptidase AOD59_07565 ENOG4108JIC nucleoside recognition domain protein AOD59_07575 ENOG4105FE9 pseudouridine synthase AOD59_07585 ENOG4107TWT Cytochrome c biogenesis protein AOD59_07590 ENOG4105CRE cytochrome C AOD59_07595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_07600 ENOG4105BZU Histidine kinase AOD59_07605 ENOG4108WBT adenosyltransferase AOD59_07620 ENOG4108SAX Membrane AOD59_07630 ENOG4105T7X AOD59_07635 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD59_07640 ENOG4105I7S Abortive infection protein AOD59_07655 ENOG4107X2D transcriptional regulator, merr family AOD59_07660 ENOG4108S6Z Negative regulator of genetic competence AOD59_07685 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AOD59_07690 ENOG4107RB3 L-asparaginase AOD59_07725 ENOG4105S2F AOD59_07730 ENOG41065D1 AOD59_07760 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AOD59_07775 ENOG4105XXQ heptaprenyl diphosphate synthase component I AOD59_07785 ENOG4105EAH synthase AOD59_07805 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD59_07810 ENOG41068YB TPR repeat-containing protein AOD59_07825 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AOD59_07830 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AOD59_07835 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AOD59_07865 ENOG4108JYZ YitT family AOD59_07875 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AOD59_07890 ENOG4105FJR Lmbe family AOD59_07895 ENOG4105CPK Glycosyl transferase (Group 1 AOD59_07935 ENOG4105DVT helicase AOD59_07940 ENOG4105YAC AOD59_07960 ENOG4105CSM endonuclease III AOD59_07970 ENOG4105BZ4 penicillin-binding protein AOD59_08020 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AOD59_08030 ENOG4105DVT helicase AOD59_08035 ENOG4105CTD carboxy-peptidase AOD59_08050 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AOD59_08060 ENOG4105C2W permease AOD59_08065 ENOG4105DHF Membrane AOD59_08070 ENOG410890F Dynamin family AOD59_08080 ENOG4108W0I acetyltransferase AOD59_08090 ENOG4105KHC sulfurtransferase AOD59_08105 ENOG4106032 Glutathionylspermidine synthase AOD59_08165 ENOG4105CPK Glycosyl transferase (Group 1 AOD59_08180 ENOG4108SZE gCN5-related N-acetyltransferase AOD59_08200 ENOG41081VK Ribonuclease AOD59_08265 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD59_08275 ENOG4107RWR Sodium hydrogen exchanger AOD59_08280 ENOG4105CN5 Metallo-Beta-Lactamase AOD59_08285 ENOG4108Z5V transcriptional regulator, merr family AOD59_08295 ENOG4105H67 Protein of unknown function (DUF421) AOD59_08300 ENOG41080C8 DUF218 domain AOD59_08355 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AOD59_08365 ENOG4107R0U MotA TolQ exbB proton channel AOD59_08370 ENOG4105ER2 Ompa motb domain protein AOD59_08375 ENOG4107YTP response regulator receiver protein AOD59_08385 ENOG4105DD5 Flagellar motor switch protein AOD59_08400 ENOG4105BZU Histidine kinase AOD59_08420 ENOG4105E1Q flagellar hook-associated protein AOD59_08425 ENOG4105DTJ flagellar hook-associated protein AOD59_08450 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AOD59_08455 ENOG4108ZC9 flagellar basal-body rod protein flgc AOD59_08460 ENOG41075Z6 flagellar hook-basal body complex protein fliE AOD59_08465 ENOG4107U2N Flagellar M-ring protein AOD59_08475 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AOD59_08510 ENOG4105BZE flagellar hook protein, FlgE AOD59_08535 ENOG4105K64 Glycosyl transferase, family 2 AOD59_08565 ENOG4107TVC Glycosyl transferase, family 2 AOD59_08590 ENOG4105I03 Flagellin AOD59_08595 ENOG4105E4C Lytic transglycosylase catalytic AOD59_08610 ENOG4105DD5 Flagellar motor switch protein AOD59_08620 ENOG4105CN7 Flagellar biosynthetic protein FliP AOD59_08625 ENOG4105VS8 Flagellar biosynthetic protein fliq AOD59_08635 ENOG4105D00 flagellar biosynthetic protein flhB AOD59_08640 ENOG4105D7B Flagellar biosynthesis protein flha AOD59_08650 ENOG4105KTQ flagellar basal-body rod protein AOD59_08655 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD59_08680 ENOG4108RZE Tetr family transcriptional regulator AOD59_08700 ENOG4105KAC Antibiotic biosynthesis monooxygenase AOD59_08725 ENOG4105DUM transcriptional regulator, lysR family AOD59_08730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AOD59_08735 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AOD59_08740 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AOD59_08745 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AOD59_08780 ENOG4105CVJ phosphoglycerate mutase AOD59_08810 ENOG4105CAQ asparagine synthetase AOD59_08830 ENOG4105PGM cation diffusion facilitator family transporter AOD59_08840 ENOG4105DRR Transcriptional regulator, GntR family AOD59_08845 ENOG4108UZ3 Transporter AOD59_08850 ENOG4105CKI cobalamin synthesis protein AOD59_08855 ENOG4108PJD permease AOD59_08870 ENOG4105DFD Na H antiporter AOD59_08875 ENOG4105C9Q fumarate hydratase class II AOD59_08905 ENOG4105EC3 peptidase S51, dipeptidase E AOD59_08925 ENOG4107QIV Cytochrome c biogenesis protein AOD59_08960 ENOG4106BRA Membrane AOD59_08995 ENOG4105CJ1 ABC, transporter AOD59_09015 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AOD59_09025 ENOG4108IJ0 Aspartate ammonia-lyase AOD59_09030 ENOG4105C6K Malic enzyme AOD59_09100 ENOG4105FVX AOD59_09140 ENOG4105CSR polyphosphate kinase 2 AOD59_09160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AOD59_09175 ENOG4105EU0 Major facilitator Superfamily AOD59_09180 ENOG4105C6T cysteine synthase AOD59_09200 ENOG4105C8J )-transporter AOD59_09210 ENOG4105X5K response regulator receiver protein AOD59_09215 ENOG4105H67 Protein of unknown function (DUF421) AOD59_09230 ENOG4106KE4 Dehydrogenase AOD59_09245 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AOD59_09250 ENOG4105CHR reductase AOD59_09255 ENOG4105CM2 brancheD-chain amino acid aminotransferase AOD59_09260 ENOG4105C7K acetolactate synthase AOD59_09265 ENOG4108ZP8 Acetolactate synthase small subunit AOD59_09270 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AOD59_09280 ENOG4105C7B Threonine dehydratase AOD59_09305 ENOG4105C6X Major Facilitator AOD59_09310 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AOD59_09320 ENOG4105DY9 regulatoR AOD59_09325 ENOG4105CYC Transferase AOD59_09345 ENOG4105F6J Alpha beta hydrolase fold AOD59_09350 ENOG4108J59 Extracellular solute-binding protein, family 5 AOD59_09380 ENOG41068WN AOD59_09400 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AOD59_09405 ENOG4105C72 UPF0176 protein AOD59_09415 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AOD59_09450 ENOG4107RHR regulatoR AOD59_09460 ENOG4105D9N nucleoside AOD59_09465 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AOD59_09500 ENOG4107RAQ aminopeptidase AOD59_09505 ENOG4107STQ Multicopper oxidase AOD59_09550 ENOG4108T5E Copper resistance protein AOD59_09555 ENOG4105KTB nuclear export factor GLE1 AOD59_09565 ENOG4107RT3 EamA-like transporter family AOD59_09570 ENOG4105GZI Transcriptional regulator AOD59_09575 ENOG4108Z40 Transcriptional regulator AOD59_09580 ENOG4107ZXU DSBA oxidoreductase AOD59_09585 ENOG4108TVJ Nitroreductase AOD59_09595 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD59_09600 ENOG4106F5Q Membrane AOD59_09605 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD59_09615 ENOG4105CKI cobalamin synthesis protein AOD59_09635 ENOG4108Z7G MaoC domain protein dehydratase AOD59_09640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD59_09650 ENOG4105C0Z ABC transporter AOD59_09655 ENOG4108IV0 ABC, transporter AOD59_09660 ENOG4105C32 Amino acid ABC transporter (Permease) AOD59_09670 ENOG4105SKE transcriptional Regulator LysR family AOD59_09690 ENOG4105YGB Transcriptional regulator AOD59_09700 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD59_09705 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD59_09710 ENOG4108JJ9 ABC, transporter AOD59_09715 ENOG4108JJ8 (ABC) transporter AOD59_09760 ENOG4105BZ1 (ABC) transporter AOD59_09765 ENOG4105BZ1 (ABC) transporter AOD59_09770 ENOG4105EFI regulatoR AOD59_09775 ENOG4105BZU Histidine kinase AOD59_09795 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AOD59_09800 ENOG4108ZJ4 polysaccharide deacetylase AOD59_09820 ENOG4105D6E homoserine dehydrogenase AOD59_09845 ENOG4108KGH TRANSCRIPTIONal AOD59_09855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_09860 ENOG4105BZU Histidine kinase AOD59_09865 ENOG4107VMI polysaccharide deacetylase AOD59_09875 ENOG4105KT7 mgtC SapB transporter AOD59_09880 ENOG4105VRR gCN5-related N-acetyltransferase AOD59_09890 ENOG4105DUU IucA IucC family protein AOD59_09895 ENOG4105CEY Amp-dependent synthetase and ligase AOD59_09910 ENOG4108WBH protein TIM barrel AOD59_09915 ENOG4105YWU small acid-soluble spore protein AOD59_09925 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AOD59_09975 ENOG4105KRN Transcriptional regulator, abrb family AOD59_09985 ENOG4105YVS arsR family transcriptional regulator AOD59_09990 ENOG4107SET aldo keto reductase AOD59_09995 ENOG4107XZQ multidrug resistance protein AOD59_10020 ENOG4105C8Q Methyl-accepting chemotaxis AOD59_10040 ENOG4108K88 Membrane AOD59_10045 ENOG4108WPJ Ferritin-like domain AOD59_10060 ENOG4105DEN Luciferase family AOD59_10080 ENOG4107QM2 Aldo Keto reductase AOD59_10085 ENOG4105CKI cobalamin synthesis protein AOD59_10150 ENOG4105DSE periplasmic solute binding protein AOD59_10160 ENOG4105K4T epimerase AOD59_10170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD59_10195 ENOG4105CVJ phosphoglycerate mutase AOD59_10215 ENOG4107T5V SNARE associated Golgi AOD59_10230 ENOG4108PJD permease AOD59_10240 ENOG4108S4H thioesterase Superfamily protein AOD59_10245 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AOD59_10265 ENOG4105SXS Protein of unknown function (DUF456) AOD59_10270 ENOG4105C37 (CBS) domain AOD59_10290 ENOG4108Z7R Chaperone CsaA AOD59_10310 ENOG4108ZRV stage ii sporulation protein p AOD59_10320 ENOG4108VXD carboxy-peptidase AOD59_10330 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AOD59_10355 ENOG4108X4Q Hydrolase AOD59_10365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AOD59_10370 ENOG4107RBS Methyltransferase AOD59_10385 ENOG41087PP glycosyltransferase MGT family AOD59_10390 ENOG4108JYZ YitT family AOD59_10395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AOD59_10420 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AOD59_10470 ENOG4105KBJ sporulation protein ytfj AOD59_10495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AOD59_10515 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AOD59_10520 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_10530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AOD59_10535 ENOG4105EMN RNA polymerase sigma factor AOD59_10560 ENOG4108V06 Glutathione peroxidase AOD59_10575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD59_10595 ENOG4108IUE nitrate reductase beta subunit AOD59_10600 ENOG4105R3A Nitrate reductase AOD59_10625 ENOG4107V6Q Cyclic nucleotide-binding domain AOD59_10630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AOD59_10635 ENOG4105D06 uba thif-type nad fad binding protein AOD59_10640 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD59_10645 ENOG4108ZAF Molybdopterin AOD59_10670 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AOD59_10675 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AOD59_10680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AOD59_10685 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AOD59_10690 ENOG4108IFG nitrite reductase, (NAD(P)H) AOD59_10695 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AOD59_10730 ENOG4105MCT stage V sporulation protein S AOD59_10745 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD59_10765 ENOG4105C5H ABC transporter AOD59_10780 ENOG4108UUM single-stranded DNA-binding protein AOD59_10795 ENOG41061H0 Monooxygenase AOD59_10815 ENOG4107YX5 Pfam:DUF548 AOD59_10820 ENOG4105C75 arginyL-tRNA synthetase AOD59_10845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD59_10860 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AOD59_10865 ENOG4105C5S asparaginyl-tRNA synthetase AOD59_10885 ENOG4105EC2 ftsk spoIIIe AOD59_10980 ENOG4105BZW Glycerate kinase AOD59_10985 ENOG4107QPK )-transporter AOD59_10990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_10995 ENOG41062D9 Histidine kinase AOD59_11010 ENOG4105C8J )-transporter AOD59_11030 ENOG4107XGZ Hydrolase AOD59_11035 ENOG4105CY2 Citrate transporter AOD59_11040 ENOG4105C0A alcohol dehydrogenase AOD59_11055 ENOG4105KD7 acetyltransferase AOD59_11085 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AOD59_11105 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AOD59_11120 ENOG4107RVG penicillin-binding protein AOD59_11125 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AOD59_11130 ENOG4105E9Q Acyl-transferase AOD59_11135 ENOG4108UT2 hemolysin iii AOD59_11145 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AOD59_11155 ENOG4108RCR degv family AOD59_11160 ENOG4105E8R UPF0173 metal-dependent hydrolase AOD59_11165 ENOG4108KF3 Electron transport protein SCO1 SenC AOD59_11170 ENOG4107Y70 Heat shock protein AOD59_11175 ENOG4105CAQ asparagine synthetase AOD59_11195 ENOG4108MES Periplasmic binding protein AOD59_11200 ENOG4105F0I Aminotransferase AOD59_11235 ENOG4105D8X mechanosensitive ion channel AOD59_11240 ENOG4105BZU Histidine kinase AOD59_11245 ENOG4105WH1 Two component transcriptional regulator luxr family AOD59_11255 ENOG4106KNT transcriptional regulator AOD59_11290 ENOG4105CMG Carbohydrate kinase AOD59_11295 ENOG4105CMG Carbohydrate kinase AOD59_11325 ENOG4108IJ8 ABC transporter AOD59_11330 ENOG4105E90 ABC transporter AOD59_11365 ENOG4105C37 (CBS) domain AOD59_11390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD59_11405 ENOG4107S4Y M20 DapE family protein YgeY AOD59_11410 ENOG4108TSC N-acetyltransferase AOD59_11415 ENOG4108JUB Transcriptional regulator AOD59_11420 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AOD59_11460 ENOG4108N23 SpoOM-related protein AOD59_11465 ENOG410841Q phosphoesterase PA-phosphatase related protein AOD59_11475 ENOG4105SZ6 Thioredoxin AOD59_11490 ENOG4108IBT Inherit from COG: transposase AOD59_11590 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AOD59_11630 ENOG4105BZ4 penicillin-binding protein AOD59_11640 ENOG4105CZM Major Facilitator AOD59_11645 ENOG4105W8X HesB YadR YfhF-family protein AOD59_11655 ENOG4105DXD 2-methylcitrate dehydratase AOD59_11660 ENOG4105CR4 methylisocitrate lyase AOD59_11665 ENOG4105C1G acyl-Coa dehydrogenase AOD59_11670 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AOD59_11680 ENOG4105N14 lysine exporter protein LysE YggA AOD59_11685 ENOG4105E39 Enoyl-CoA hydratase AOD59_11700 ENOG4107RFY SbcCD D subunit AOD59_11705 ENOG4105EYH Exonuclease AOD59_11735 ENOG4105FCD Major Facilitator AOD59_11740 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AOD59_11745 ENOG4105E4F Isochorismate synthase AOD59_11750 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AOD59_11755 ENOG4105WQI isochorismatase AOD59_11760 ENOG4105CEY Amp-dependent synthetase and ligase AOD59_11765 ENOG4105WQT MbtH domain protein AOD59_11770 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_11785 ENOG4105K70 DNA-binding protein AOD59_11805 ENOG4105BZG amino acid carrier protein AOD59_11830 ENOG4105FE9 pseudouridine synthase AOD59_11835 ENOG4105C22 threonyL-tRNA synthetase AOD59_11850 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD59_11875 ENOG4108D32 Methyltransferase AOD59_11905 ENOG41081I9 integral membrane protein AOD59_11920 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD59_11930 ENOG4105EYF MMPL domain protein AOD59_11955 ENOG4105WCN acetyltransferase AOD59_11985 ENOG4105C1Q protoporphyrinogen oxidase AOD59_11995 ENOG41068WN AOD59_12005 ENOG4105VEQ Cold shock protein AOD59_12025 ENOG410667J hydrolase AOD59_12070 ENOG4107V2S Transcriptional regulator AOD59_12075 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD59_12090 ENOG4105DND Transcriptional regulator AOD59_12095 ENOG4108RPX mosc domain containing protein AOD59_12110 ENOG4105BZ1 (ABC) transporter AOD59_12115 ENOG4105BZ1 (ABC) transporter AOD59_12135 ENOG4108JCI Transcriptional regulator AOD59_12165 ENOG4108KPJ rna polymerase sigma factor AOD59_12190 ENOG4105F32 YngK protein AOD59_12215 ENOG4105RD7 BadF BadG BcrA BcrD AOD59_12225 ENOG4107STF Involved in phosphonate degradation (By similarity) AOD59_12245 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AOD59_12260 ENOG4105C1J atp-dependent rna helicase AOD59_12275 ENOG4108RZE Tetr family transcriptional regulator AOD59_12295 ENOG41088CC tellurite resistance protein tehB AOD59_12305 ENOG4108I0C methyltransferase AOD59_12310 ENOG4107RA9 decarboxylase AOD59_12315 ENOG41090HR transcriptional regulator AOD59_12355 ENOG4105CIN aminoacyl-histidine dipeptidase AOD59_12380 ENOG4107RF6 penicillin-binding protein AOD59_12395 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AOD59_12400 ENOG4105ETE Transcriptional regulator (LacI family AOD59_12405 ENOG4105IE8 Alpha-ketoglutarate permease AOD59_12410 ENOG4105CK5 oxidoreductase AOD59_12435 ENOG4105D2N Aldolase AOD59_12440 ENOG4105DH8 myo-inositol catabolism AOD59_12455 ENOG4105CGH 5'-nucleotidase AOD59_12465 ENOG4105CGH 5'-nucleotidase AOD59_12480 ENOG4105VZ8 Transcriptional regulator AOD59_12495 ENOG4108VXD carboxy-peptidase AOD59_12515 ENOG41067SE Tetr family transcriptional regulator AOD59_12520 ENOG4105C5H ABC transporter AOD59_12530 ENOG4105BZU Histidine kinase AOD59_12540 ENOG4106ANW SMI1_KNR4 AOD59_12545 ENOG4105CEP NADH dehydrogenase AOD59_12550 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AOD59_12565 ENOG4105CJ1 ABC, transporter AOD59_12575 ENOG4107Z3H Transcriptional regulator, TetR family AOD59_12590 ENOG4105C1G acyl-Coa dehydrogenase AOD59_12595 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD59_12600 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AOD59_12605 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AOD59_12610 ENOG4105E39 Enoyl-CoA hydratase AOD59_12615 ENOG4107QX3 carboxylase AOD59_12620 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD59_12630 ENOG4105WCN acetyltransferase AOD59_12635 ENOG4105DBI uridine monophosphokinase AOD59_12670 ENOG4105T9C HD domain AOD59_12680 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AOD59_12720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD59_12720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD59_12735 ENOG4105FQP Beta-lactamase AOD59_12745 ENOG4107Y80 Major Facilitator superfamily AOD59_12765 ENOG4105CUV Homoserine Kinase AOD59_12800 ENOG4105CPQ Dehydrogenase AOD59_12815 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD59_12820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD59_12915 ENOG4105ETU transcriptional activator (TenA AOD59_13025 ENOG410667J hydrolase AOD59_13035 ENOG4105BZU Histidine kinase AOD59_13040 ENOG4107RF6 penicillin-binding protein AOD59_13060 ENOG4108JJB ABC transporter AOD59_13070 ENOG4108HGU Histidine kinase AOD59_13085 ENOG4105CB2 alcohol dehydrogenase AOD59_13090 ENOG4105CJN penicillin-binding protein AOD59_13100 ENOG4105FQP Beta-lactamase AOD59_13135 ENOG4108V4B ThiJ pfpI AOD59_13165 ENOG4107Y80 Major Facilitator superfamily AOD59_13180 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD59_13200 ENOG4107Y9U Membrane AOD59_13235 ENOG4105FCD Major Facilitator AOD59_13250 ENOG4105E09 nadh pyrophosphatase AOD59_13255 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AOD59_13260 ENOG4108Z4K mutator MutT protein AOD59_13295 ENOG4108XI2 Domain of unknown function (DUF1963) AOD59_13325 ENOG4108NRW Phospholipase, patatin family AOD59_13330 ENOG4105KWG Pfam:DUF1696 AOD59_13365 ENOG4105PKS Excinuclease abc c subunit domain protein AOD59_13405 ENOG4107VFR oxidoreductase AOD59_13430 ENOG4105PAD Hydrolase AOD59_13450 ENOG4105DY8 decarboxylase AOD59_13465 ENOG4108IUM Glycogen debranching enzyme AOD59_13490 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AOD59_13500 ENOG4105FDR Membrane AOD59_13535 ENOG4108V3A UPF0421 protein AOD59_13555 ENOG4105MSI germination protein ypeb AOD59_13575 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) AOD59_13580 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AOD59_13585 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AOD59_13590 ENOG4107Z3H Transcriptional regulator, TetR family AOD59_13620 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AOD59_13640 ENOG4105E98 transcriptional regulator DeoR family AOD59_13660 ENOG41062ES Transcriptional regulator AOD59_13680 ENOG4107QKR Dehydrogenase AOD59_13690 ENOG4107RUY (E1 component), alpha subunit AOD59_13700 ENOG4105E1F short-chain dehydrogenase reductase AOD59_13705 ENOG4105RHY Pfam:UPF0157 AOD59_13740 ENOG4107SQ8 Glycine betaine AOD59_13745 ENOG4108IJ7 Glycine betaine AOD59_13770 ENOG4105E66 phosphoriboisomerase A AOD59_13775 ENOG41082BV acetyltransferase AOD59_13780 ENOG4108M1A Chitin-binding protein AOD59_13825 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD59_13875 ENOG4105EEM helicase AOD59_13895 ENOG4105C9U ATP-dependent DNA helicase RecQ AOD59_13950 ENOG4108M1A Chitin-binding protein AOD59_13965 ENOG4105BZG amino acid carrier protein AOD59_13970 ENOG4105C26 Dehydrogenase AOD59_13975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD59_13980 ENOG4105CTU Proline racemase AOD59_13985 ENOG4105CTU Proline racemase AOD59_13990 ENOG41080HI glycine oxidase AOD59_14030 ENOG4107T5V SNARE associated Golgi AOD59_14045 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AOD59_14050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AOD59_14065 ENOG4105DTQ mandelate racemase muconate lactonizing AOD59_14105 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AOD59_14110 ENOG4105BZU Histidine kinase AOD59_14115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_14155 ENOG4105EPR degv family AOD59_14195 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AOD59_14200 ENOG4106K7D Major facilitator family transporter AOD59_14220 ENOG4107BMA Transglycosylase associated protein AOD59_14235 ENOG41089UC methyltransferase, type 11 AOD59_14270 ENOG4105CHM Aminotransferase AOD59_14305 ENOG4105DVE abc transporter atp-binding protein AOD59_14355 ENOG4105C02 permease AOD59_14370 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AOD59_14375 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AOD59_14380 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AOD59_14405 ENOG4105E09 nadh pyrophosphatase AOD59_14425 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AOD59_14475 ENOG4107VC0 DNA alkylation repair enzyme AOD59_14485 ENOG4107VMI polysaccharide deacetylase AOD59_14495 ENOG4108ZCF integral membrane protein AOD59_14500 ENOG4105E0M Sulfatase AOD59_14505 ENOG4105C5H ABC transporter AOD59_14515 ENOG4105EYF MMPL domain protein AOD59_14520 ENOG4105EYF MMPL domain protein AOD59_14525 ENOG4105EYF MMPL domain protein AOD59_14530 ENOG41082JN Transcriptional regulator AOD59_14550 ENOG4105CIH Imidazole acetol-phosphate transaminase AOD59_14555 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AOD59_14560 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AOD59_14595 ENOG41069ER domain protein AOD59_14605 ENOG4105EMN RNA polymerase sigma factor AOD59_14630 ENOG4105D4B ABC, transporter AOD59_14640 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AOD59_14650 ENOG4105DKT Transcriptional regulator AOD59_14665 ENOG41061GT Aldolase AOD59_14685 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AOD59_14715 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AOD59_14720 ENOG4105II7 pyrroline-5-carboxylate reductase AOD59_14730 ENOG4107258 Transcriptional regulator AOD59_14740 ENOG4105E0Y RtcB Protein AOD59_14745 ENOG4105ECK Fatty Acid Desaturase AOD59_14750 ENOG4105G6Z alkaline phosphatase AOD59_14760 ENOG4105VMP Transcriptional regulator AOD59_14775 ENOG41090T1 Membrane AOD59_14785 ENOG4108WCX response regulator AOD59_14795 ENOG41068WN AOD59_14820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD59_14845 ENOG4105CKK Glycosyl transferase, family 2 AOD59_14870 ENOG4105CKK Glycosyl transferase, family 2 AOD59_14880 ENOG4105C8Y Acetylornithine aminotransferase AOD59_14920 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AOD59_14930 ENOG4108TVJ Nitroreductase AOD59_14935 ENOG4105FS7 Transcriptional regulator AOD59_14970 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD59_14980 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AOD59_15010 ENOG4108XET gCN5-related N-acetyltransferase AOD59_15090 ENOG410635A Membrane AOD59_15095 ENOG4105KNA -acetyltransferase AOD59_15100 ENOG4108IQI permease AOD59_15110 ENOG4105F1N DNA alkylation repair AOD59_15150 ENOG4107RF6 penicillin-binding protein AOD59_15160 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AOD59_15200 ENOG4105P4J Allophanate hydrolase, subunit 1 AOD59_15205 ENOG4107258 Transcriptional regulator AOD59_15215 ENOG4106N3A copper homeostasis protein cutc AOD59_15220 ENOG4108ZRV stage ii sporulation protein p AOD59_15225 ENOG4108ZHR arsR family transcriptional regulator AOD59_15235 ENOG4105FDT acyl-CoA dehydrogenase AOD59_15255 ENOG4105DWD nucleoside recognition domain protein AOD59_15285 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AOD59_15350 ENOG4105E2A Dehydrogenase AOD59_15365 ENOG4108IJ0 Aspartate ammonia-lyase AOD59_15370 ENOG4105HDK L-asparaginase AOD59_15375 ENOG4108IMY Transcriptional regulator AOD59_15385 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AOD59_15390 ENOG4105CUB amino acid AOD59_15400 ENOG4105II7 pyrroline-5-carboxylate reductase AOD59_15410 ENOG4105C6K Malic enzyme AOD59_15420 ENOG4108NHD germination protein AOD59_15425 ENOG4108NHD germination protein AOD59_15430 ENOG4108Q8B Spore germination protein AOD59_15450 ENOG4105CSV Glutaminase AOD59_15480 ENOG4105CGH 5'-nucleotidase AOD59_15485 ENOG4105CH6 catalase AOD59_15495 ENOG4105CHJ isochorismatase hydrolase AOD59_15560 ENOG4108606 TspO/MBR family AOD59_15565 ENOG4105CVP deoxyribo-dipyrimidine photolyase AOD59_15580 ENOG4108TWJ NADH dehydrogenase subunit 5 AOD59_15585 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AOD59_15595 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD59_15600 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AOD59_15605 ENOG4105DSE periplasmic solute binding protein AOD59_15610 ENOG4105CC5 ABC transporter AOD59_15615 ENOG4105DIK (ABC) transporter AOD59_15645 ENOG4105D6J arsenicaL-resistance protein AOD59_15650 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_15655 ENOG41085FC arsR family transcriptional regulator AOD59_15670 ENOG4105F7F Chaperone AOD59_15680 ENOG4105CHR reductase AOD59_15685 ENOG4108YXU transcriptional regulator AsnC family AOD59_15760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AOD59_15770 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_15780 ENOG4105IIP Membrane AOD59_15795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_15800 ENOG41062D9 Histidine kinase AOD59_15830 ENOG4105K6H D-cysteine desulfhydrase AOD59_15855 ENOG4105VZ8 Transcriptional regulator AOD59_15870 ENOG4108NNI Beta-lactamase domain-containing protein AOD59_15875 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AOD59_15885 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AOD59_15890 ENOG4105JQZ Methyltransferase AOD59_15905 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD59_15910 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AOD59_15930 ENOG4105BZU Histidine kinase AOD59_15945 ENOG4108U05 Transcriptional regulator AOD59_15960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AOD59_15965 ENOG4105DJB Major Facilitator Superfamily AOD59_15970 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AOD59_15975 ENOG4107QR9 Iron-sulfur cluster binding protein AOD59_15985 ENOG4106P55 Transcriptional regulator AOD59_15995 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AOD59_16030 ENOG4105TRI Hydrolase AOD59_16065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD59_16095 ENOG4107QJQ Mate efflux family protein AOD59_16110 ENOG4105EQ0 Major Facilitator superfamily AOD59_16115 ENOG4108JGH Tetr family transcriptional regulator AOD59_16130 ENOG4105C44 Serine transporter AOD59_16135 ENOG4105EJQ L-serine dehydratase AOD59_16150 ENOG4108JPW Aminotransferase AOD59_16165 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AOD59_16175 ENOG4105DVH amino acid AOD59_16190 ENOG4108JQ1 Dehydrogenase AOD59_16210 ENOG4108AEY RNA polymerase sigma factor AOD59_16225 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD59_16235 ENOG410874W AraC family transcriptional regulator AOD59_16250 ENOG4105HIR S-layer domain protein AOD59_16290 ENOG4108ISG Major Facilitator AOD59_16300 ENOG4107MII Sugar-specific transcriptional regulator TrmB AOD59_16305 ENOG4105CZM Major Facilitator AOD59_16325 ENOG4105DA5 (ABC) transporter AOD59_16330 ENOG41069JR AOD59_16340 ENOG4105RXJ AOD59_16345 ENOG4105KPY Small multidrug resistance protein AOD59_16350 ENOG4105KBX Transcriptional regulator, TetR family AOD59_16365 ENOG4105CRW Short chain fatty acid transporter AOD59_16375 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD59_16405 ENOG4108JJB ABC transporter AOD59_16410 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AOD59_16435 ENOG4108K8S endonuclease I AOD59_16450 ENOG41067QW Transcriptional regulator AOD59_16460 ENOG4108Z66 YbaK ebsC protein AOD59_16465 ENOG4105CUT histidyl-tRNA synthetase AOD59_16480 ENOG4105KVH Transcriptional regulator AOD59_16485 ENOG4108RCM Nitroreductase AOD59_16505 ENOG4108PSK reductase AOD59_16515 ENOG4105CJ1 ABC, transporter AOD59_16575 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_16580 ENOG4105DKQ ROK family AOD59_16585 ENOG4106UW1 Major Facilitator superfamily AOD59_16590 ENOG4108UW5 maltose o-acetyltransferase AOD59_16605 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AOD59_16610 ENOG4105C31 Tryptophanyl-tRNA synthetase AOD59_16615 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD59_16640 ENOG4105DMQ Methyltransferase AOD59_16650 ENOG4105EV4 Multidrug resistance protein mdtH AOD59_16680 ENOG4105C37 (CBS) domain AOD59_16695 ENOG4105DDN Pentapeptide repeat-containing protein AOD59_16700 ENOG4105XDF Protein of unknown function (DUF1272) AOD59_16705 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AOD59_16710 ENOG4105CMG Carbohydrate kinase AOD59_16715 ENOG4105C6Z Gluconate AOD59_16720 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AOD59_16735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD59_16740 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AOD59_16745 ENOG4105CIS alcohol dehydrogenase AOD59_16750 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AOD59_16770 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AOD59_16775 ENOG4105D4Y metalloprotease AOD59_16795 ENOG4105CV8 reductase AOD59_16800 ENOG4105F27 Major Facilitator AOD59_16815 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AOD59_16820 ENOG4105C44 Serine transporter AOD59_16855 ENOG4105KVH Transcriptional regulator AOD59_16860 ENOG4108TZY GntR Family Transcriptional Regulator AOD59_16870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AOD59_16875 ENOG4105KVH Transcriptional regulator AOD59_16880 ENOG4105KVH Transcriptional regulator AOD59_16915 ENOG4105JAB phenazine biosynthesis protein, phzf family AOD59_16925 ENOG4105CHR reductase AOD59_16945 ENOG4105KVH Transcriptional regulator AOD59_17015 ENOG4105KAF membrAne AOD59_17040 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AOD59_17055 ENOG4107YXZ hydrolase, family 25 AOD59_17080 ENOG4105ED2 Beta-lactamase AOD59_17090 ENOG4105H3G oxidoreductase AOD59_17165 ENOG4108TN2 lmbE family AOD59_17175 ENOG4107R3E Citrate transporter AOD59_17195 ENOG4108MES Periplasmic binding protein AOD59_17205 ENOG4105EHG Permease protein AOD59_17210 ENOG4105DQ5 transport system permease protein AOD59_17215 ENOG4105NX3 Membrane AOD59_17220 ENOG4107ZY0 Phenazine biosynthesis-like protein AOD59_17240 ENOG4107CUJ Protein of unknown function (DUF2690) AOD59_17250 ENOG4107V2S Transcriptional regulator AOD59_17270 ENOG4105C98 muts2 protein AOD59_17280 ENOG4105E5K Alpha-amylase AOD59_17285 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AOD59_17290 ENOG4105DPN Oligoendopeptidase f AOD59_17295 ENOG4108A04 Beta-lactamase AOD59_17325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AOD59_17350 ENOG41082BM Transcriptional regulator, arsr family AOD59_17355 ENOG4105CIS alcohol dehydrogenase AOD59_17380 ENOG4105RHY Pfam:UPF0157 AOD59_17390 ENOG4105C09 Bile acid AOD59_17395 ENOG4105CQB FAD linked oxidase domain protein AOD59_17420 ENOG4108UT6 Transferase hexapeptide repeat containing protein AOD59_17430 ENOG4105K64 Glycosyl transferase, family 2 AOD59_17435 ENOG4105E39 Enoyl-CoA hydratase AOD59_17445 ENOG4105KT7 mgtC SapB transporter AOD59_17455 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_17460 ENOG41073R8 VanW family AOD59_17470 ENOG4108R1P AOD59_17490 ENOG4105VEQ Cold shock protein AOD59_17510 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AOD59_17530 ENOG410904N short-chain dehydrogenase reductase AOD59_17540 ENOG4106IQC argininosuccinate lyase AOD59_17555 ENOG4108IA2 Sodium pantothenate symporter AOD59_17565 ENOG4105C26 Dehydrogenase AOD59_17570 ENOG4105CHR reductase AOD59_17580 ENOG4105EWU Squalene--hopene cyclase AOD59_17590 ENOG4105FR1 rard protein AOD59_17595 ENOG410696E Membrane AOD59_17610 ENOG4105D1F ATP-binding protein AOD59_17620 ENOG4108ZAF Molybdopterin AOD59_17625 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD59_17630 ENOG4105D06 uba thif-type nad fad binding protein AOD59_17635 ENOG4105TMB Formate nitrite transporter AOD59_17645 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AOD59_17650 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AOD59_17660 ENOG4108JB9 formate dehydrogenase AOD59_17670 ENOG4105E1K spore germination protein AOD59_17730 ENOG4107QJT sodium dicarboxylate symporter AOD59_17735 ENOG4108KGH TRANSCRIPTIONal AOD59_17745 ENOG4105EMN RNA polymerase sigma factor AOD59_17770 ENOG4105CIG ABC transporter AOD59_17780 ENOG4105D9R oxidoreductase AOD59_17790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AOD59_17800 ENOG4105K4P CoA-binding domain protein AOD59_17805 ENOG4105C0H protease AOD59_17810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_17820 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AOD59_17825 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AOD59_17830 ENOG4105W8X HesB YadR YfhF-family protein AOD59_17860 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD59_17865 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AOD59_17875 ENOG4108JJA ABC, transporter AOD59_17880 ENOG4108I0Z Aconitate hydratase AOD59_17910 ENOG4105E5W Transporter AOD59_17920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD59_17940 ENOG4107F3J Amp-dependent synthetase and ligase AOD59_17945 ENOG4107ZYJ bioY protein AOD59_17950 ENOG4105CEY Amp-dependent synthetase and ligase AOD59_17995 ENOG4107AYK membrAne AOD59_18005 ENOG4105BZU Histidine kinase AOD59_18010 ENOG4105FBA Phospholipase Carboxylesterase AOD59_18015 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AOD59_18020 ENOG4105CK7 Sodium proline symporter AOD59_18025 ENOG4105CBC glutamate synthase AOD59_18030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AOD59_18035 ENOG4108VJ1 Transcriptional regulator (CarD family AOD59_18040 ENOG4108903 Formimidoylglutamase AOD59_18065 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AOD59_18125 ENOG4107QIV Cytochrome c biogenesis protein AOD59_18135 ENOG4107RSM transcriptional regulator AOD59_18140 ENOG4105VAW lrga family AOD59_18145 ENOG41067MG lrgb family AOD59_18170 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AOD59_18185 ENOG4105BZ1 (ABC) transporter AOD59_18190 ENOG4105BZ1 (ABC) transporter AOD59_18210 ENOG4105D7V transposase AOD59_18230 ENOG4105D5T phosphonate abc transporter AOD59_18245 ENOG4105CGH 5'-nucleotidase AOD59_18255 ENOG4108SVB resolvase AOD59_18275 ENOG4105K7K Transcriptional regulator AOD59_18310 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AOD59_18315 ENOG4105XSJ toxin secretion phage lysis holin AOD59_18525 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) AOD59_18630 ENOG4105C5F glutamine synthetase AOD59_18635 ENOG4105KV4 Transcriptional regulator AOD59_18640 ENOG4105CXI aluminum resistance protein AOD59_18650 ENOG4105EN6 Membrane AOD59_18655 ENOG4106F1P AAA ATPase, central domain protein AOD59_18685 ENOG41069ER domain protein AOD59_18690 ENOG4105DM4 PTS System AOD59_18695 ENOG4105DE4 1-phosphofructokinase AOD59_18700 ENOG4105E98 transcriptional regulator DeoR family AOD59_18710 ENOG4108SJC Membrane AOD59_18725 ENOG4105C85 amino acid AOD59_18740 ENOG4105TMB Formate nitrite transporter AOD59_18745 ENOG4105K70 DNA-binding protein AOD59_18750 ENOG4105C59 p-type ATPase AOD59_18755 ENOG410681U heavy metal transport detoxification protein AOD59_18760 ENOG4105VPX protein, conserved in bacteria AOD59_18770 ENOG4105NIV Esterase AOD59_18775 ENOG4105E0A ABC, transporter AOD59_18800 ENOG4105CGK Exodeoxyribonuclease III AOD59_18810 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AOD59_18815 ENOG4105D03 DNA-3-methyladenine glycosylase II AOD59_18845 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_18850 ENOG4105BZU Histidine kinase AOD59_18870 ENOG41067MG lrgb family AOD59_18885 ENOG4107TTQ Alpha beta hydrolase fold AOD59_18890 ENOG4107YEI lmbE family AOD59_18910 ENOG4105F0V Cell wall hydrolase AOD59_18915 ENOG4107R6R udp-galactopyranose mutase AOD59_18920 ENOG4105E0M Sulfatase AOD59_18925 ENOG410890F Dynamin family AOD59_18935 ENOG4107QHE Choloylglycine hydrolase AOD59_18960 ENOG4105DA5 (ABC) transporter AOD59_18985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD59_18990 ENOG4105DQU oxidoreductase, subunit beta AOD59_18995 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AOD59_19000 ENOG4108IGT Dipeptidase AOD59_19005 ENOG4105MCT stage V sporulation protein S AOD59_19010 ENOG4105D48 metallophosphoesterase AOD59_19035 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AOD59_19050 ENOG4105XZV Protein of unknown function (DUF3243) AOD59_19055 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AOD59_19075 ENOG4105UIB (ABC) transporter AOD59_19080 ENOG4105UIB (ABC) transporter AOD59_19085 ENOG4108JQ9 ABC transporter AOD59_19090 ENOG4105DIH basic membrane AOD59_19095 ENOG4105FDP GntR family transcriptional regulator AOD59_19100 ENOG4107QZI cell division protein FtsK AOD59_19110 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AOD59_19125 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AOD59_19135 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AOD59_19140 ENOG4108S0H Dipicolinic acid synthetase, b subunit AOD59_19145 ENOG4105E35 Dipicolinate synthase subunit A AOD59_19155 ENOG4105C1V Peptidase, M16 AOD59_19175 ENOG4105DTN riboflavin biosynthesis protein ribF AOD59_19180 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AOD59_19190 ENOG4105W7A Protein of unknown function (DUF503) AOD59_19200 ENOG4105VHM ribosomal protein AOD59_19205 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AOD59_19210 ENOG4105CHV Transcription elongation factor NusA AOD59_19220 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AOD59_19230 ENOG4105DZP Membrane-associated zinc metalloprotease AOD59_19235 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AOD59_19240 ENOG4105KNE Phosphatidate cytidylyltransferase AOD59_19245 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AOD59_19285 ENOG4108HE4 integrase family AOD59_19295 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AOD59_19305 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AOD59_19320 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AOD59_19345 ENOG4105VB6 UPF0109 protein AOD59_19365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AOD59_19370 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AOD59_19385 ENOG4105CHR reductase AOD59_19390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AOD59_19405 ENOG4105CB5 ATP-dependent DNA helicase recG AOD59_19410 ENOG4105DP4 dak2 domain fusion protein ylov AOD59_19415 ENOG4108ZAA Alkaline-shock protein AOD59_19430 ENOG4105FJ0 thiamine AOD59_19435 ENOG4105DJV ribulose-phosphate 3-epimerase AOD59_19440 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AOD59_19445 ENOG4105D9P serine threonine protein kinase AOD59_19450 ENOG4108ZF3 Phosphatase AOD59_19460 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AOD59_19470 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD59_19475 ENOG4105C25 Primosomal protein n' AOD59_19480 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AOD59_19500 ENOG4105DSJ YicC domain protein AOD59_19510 ENOG4105F23 Fibronectin-binding protein AOD59_19515 ENOG4105DC7 peptidase M24 AOD59_19570 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AOD59_19595 ENOG4105C34 Pseudouridine synthase AOD59_19610 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AOD59_19620 ENOG4105DBK s4 domain protein AOD59_19625 ENOG41067XK integral membrane protein AOD59_19635 ENOG4105DFA alanine racemase domain protein AOD59_19640 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AOD59_19645 ENOG4105WR5 sporulation protein, YlmC YmxH family AOD59_19655 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_19665 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AOD59_19670 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AOD59_19675 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AOD59_19680 ENOG4105D4A Cell wall formation (By similarity) AOD59_19685 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD59_19690 ENOG4105CNI cell division protein FtsW AOD59_19705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AOD59_19710 ENOG4105CJN penicillin-binding protein AOD59_19715 ENOG4105CJN penicillin-binding protein AOD59_19720 ENOG41068DC Essential cell division protein (By similarity) AOD59_19755 ENOG4105KNH Nucleic acid-binding protein AOD59_19805 ENOG4105XSJ toxin secretion phage lysis holin AOD59_19890 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD59_19900 ENOG4105CAR Terminase, large subunit AOD59_19990 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AOD59_20000 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_20055 ENOG4108IMY Transcriptional regulator AOD59_20080 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AOD59_20090 ENOG41063PX domain protein AOD59_20095 ENOG4105D78 K07001 NTE family protein AOD59_20100 ENOG4105H20 Sporulation integral membrane protein YlbJ AOD59_20110 ENOG4106H78 methyltransferase AOD59_20130 ENOG4107TB6 phosphoglycerate mutase AOD59_20145 ENOG4106UY4 Inherit from COG: Scp-like extracellular AOD59_20195 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AOD59_20200 ENOG4105CNI cell division protein FtsW AOD59_20215 ENOG4108IAB Phoh family AOD59_20235 ENOG4105QA2 AOD59_20240 ENOG4105CI3 gtp-binding protein typa AOD59_20250 ENOG4105ECY inositol monophosphatase AOD59_20270 ENOG4105CXN decarboxylase AOD59_20315 ENOG4105C7S Dehydrogenase AOD59_20320 ENOG4105CPP Dehydrogenase, E1 component AOD59_20335 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AOD59_20340 ENOG4108X4Q Hydrolase AOD59_20350 ENOG4105CN5 Metallo-Beta-Lactamase AOD59_20355 ENOG4107ZYR domain protein AOD59_20390 ENOG4108XRC Protein of unknown function (DUF458) AOD59_20400 ENOG4107IN1 Protein of unknown function (DUF1797) AOD59_20415 ENOG4105EPM Diguanylate phosphodiesterase AOD59_20420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AOD59_20435 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AOD59_20445 ENOG4105UIN AOD59_20510 ENOG4108HGU Histidine kinase AOD59_20520 ENOG4105CHM Aminotransferase AOD59_20525 ENOG4105FKQ transcriptional regulator AOD59_20530 ENOG4105EG2 ABC transporter, permease AOD59_20540 ENOG4107FKK extracellular solute-binding protein family 1 AOD59_20550 ENOG4105CG3 alpha amylase, catalytic region AOD59_20595 ENOG4105CHU acetyl-coa acetyltransferase AOD59_20635 ENOG4105K7K Transcriptional regulator AOD59_20640 ENOG4105DTD Dehydrogenase AOD59_20650 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AOD59_20660 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AOD59_20685 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AOD59_20705 ENOG4106TD9 Diguanylate cyclase AOD59_20725 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AOD59_20740 ENOG4105CID antiterminator AOD59_20750 ENOG4105FDP GntR family transcriptional regulator AOD59_20760 ENOG4105CE4 GlcNAc 6-P deacetylase AOD59_20805 ENOG4107ZE5 PPIases accelerate the folding of proteins AOD59_20810 ENOG4105PTM secreted protein AOD59_20815 ENOG4105J7I hydrolase AOD59_20825 ENOG4105G6R Stage v sporulation protein ae AOD59_20835 ENOG4105CZ3 stage V sporulation protein ad AOD59_20840 ENOG41090VF Stage v sporulation protein ac AOD59_20860 ENOG4105C8J )-transporter AOD59_20865 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_20875 ENOG41082AN stage II sporulation protein AOD59_20880 ENOG4105DZ1 carboxypeptidase AOD59_20885 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD59_20890 ENOG4105DVE abc transporter atp-binding protein AOD59_20925 ENOG4105D7N magnesium and cobalt transport protein CorA AOD59_20950 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD59_20960 ENOG4105I3K Ferric uptake regulator, Fur family AOD59_20965 ENOG4105MZ9 stage II sporulation protein m AOD59_20985 ENOG4105CPC Aldo Keto reductase AOD59_20995 ENOG4105RHY Pfam:UPF0157 AOD59_21015 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AOD59_21025 ENOG4105ETE Transcriptional regulator (LacI family AOD59_21030 ENOG4108YM7 Gcn5-related n-acetyltransferase AOD59_21050 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AOD59_21055 ENOG4108R6K riboflavin synthase, subunit alpha AOD59_21075 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AOD59_21080 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD59_21085 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AOD59_21090 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AOD59_21100 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AOD59_21110 ENOG4105DFD Na H antiporter AOD59_21115 ENOG4105CGH 5'-nucleotidase AOD59_21155 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AOD59_21170 ENOG4108IXY short-chain dehydrogenase reductase AOD59_21175 ENOG41069FQ Metallo-beta-lactamase superfamily AOD59_21185 ENOG4105II7 pyrroline-5-carboxylate reductase AOD59_21190 ENOG4105EJQ L-serine dehydratase AOD59_21215 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AOD59_21225 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AOD59_21230 ENOG4105D9U N-acetyltransferase AOD59_21245 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AOD59_21250 ENOG4108QEG Membrane AOD59_21255 ENOG4105CDA abc transporter atp-binding protein AOD59_21260 ENOG4105E5Q amino acid AbC transporter AOD59_21265 ENOG4108HW3 (ABC) transporter AOD59_21275 ENOG4105G7B Protein of unknown function (DUF2992) AOD59_21295 ENOG4105C7S Dehydrogenase AOD59_21300 ENOG4105CPP Dehydrogenase, E1 component AOD59_21320 ENOG4107RDP Dehydrogenase AOD59_21335 ENOG4108JUB Transcriptional regulator AOD59_21345 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD59_21360 ENOG4107QQR Sporulation AOD59_21370 ENOG4105S1Z Stage IV sporulation protein B AOD59_21375 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AOD59_21385 ENOG4105DX0 Hemolysin A AOD59_21395 ENOG4105CTB Polyprenyl synthetase AOD59_21420 ENOG4108ZSR alkaline shock protein AOD59_21425 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AOD59_21450 ENOG410644B Stage III sporulation protein af AOD59_21460 ENOG4105KQ4 Stage iii sporulation protein ad AOD59_21465 ENOG4108CQH stage III sporulation protein AC AOD59_21470 ENOG4105KR5 Stage iii sporulation protein AOD59_21475 ENOG4105CD2 stage iii sporulation protein aa AOD59_21500 ENOG4105DC7 peptidase M24 AOD59_21515 ENOG4105CBJ Metal-dependent enzyme AOD59_21525 ENOG4107YBY Hydrolase AOD59_21545 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AOD59_21550 ENOG4105WZW rhodanese family AOD59_21570 ENOG41080TC multidrug resistance protein AOD59_21610 ENOG4105CJ1 ABC, transporter AOD59_21615 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AOD59_21645 ENOG4105C0D helicase AOD59_21765 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AOD59_21770 ENOG4105C3R Methionine synthase AOD59_21785 ENOG4105C28 cystathionine AOD59_21790 ENOG4105C28 cystathionine AOD59_21815 ENOG4105C5X domain protein AOD59_21825 ENOG4105DKQ ROK family AOD59_21835 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AOD59_21850 ENOG4108UTW Plays a role in the regulation of phosphate uptake AOD59_21855 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AOD59_21860 ENOG4105E2Z phosphate ABC transporter (Permease AOD59_21865 ENOG4105C8U phosphate abc transporter AOD59_21870 ENOG4105PWN phosphate abc transporter AOD59_21875 ENOG4107RF6 penicillin-binding protein AOD59_21885 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD59_21910 ENOG4105N80 Ferric uptake regulator, Fur family AOD59_21920 ENOG4105FDK ABC transporter AOD59_21925 ENOG4108JYZ YitT family AOD59_21930 ENOG41069ZM Protein of unknown function (DUF2624) AOD59_21955 ENOG4105EGD dinuclear metal center protein, YbgI family AOD59_21970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_21975 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AOD59_22010 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AOD59_22015 ENOG4105KG3 cytidine deaminase AOD59_22020 ENOG4107YR5 Diacylglycerol kinase AOD59_22030 ENOG4105CTJ Metal Dependent Phosphohydrolase AOD59_22035 ENOG4105C9A Phoh family AOD59_22050 ENOG41068P3 sporulation protein YqfC AOD59_22055 ENOG4105KTH gatB Yqey AOD59_22065 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AOD59_22070 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AOD59_22090 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AOD59_22100 ENOG4105CSA Coproporphyrinogen iii oxidase AOD59_22105 ENOG4105KVH Transcriptional regulator AOD59_22130 ENOG4105TQK DNA polymerase iii, delta' subunit AOD59_22140 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AOD59_22145 ENOG4108UK2 deaminase AOD59_22150 ENOG4105KQC Competence protein AOD59_22160 ENOG4105DXX methyltransferase AOD59_22170 ENOG4108WF2 Metal Dependent Phosphohydrolase AOD59_22180 ENOG410812S Rna-binding protein AOD59_22190 ENOG4105CQW ribosome biogenesis GTPase YqeH AOD59_22195 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AOD59_22210 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_22230 ENOG4108TVJ Nitroreductase AOD59_22245 ENOG4105G6Z alkaline phosphatase AOD59_22255 ENOG4108MUZ hydrolase AOD59_22290 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AOD59_22295 ENOG4105MIR Phenylalanine 4-monooxygenase AOD59_22305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_22310 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_22350 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD59_22355 ENOG4108V5C ABC transporter AOD59_22365 ENOG4108EKI Dehydrogenase AOD59_22370 ENOG4105C28 cystathionine AOD59_22400 ENOG4107XRG penicillin-binding protein AOD59_22415 ENOG4105CFP Peptidase U32 AOD59_22420 ENOG4105XYU peptidase (U32 family) AOD59_22425 ENOG4108VQJ O-methyltransferase AOD59_22430 ENOG4105HHA aminodeoxychorismate lyase AOD59_22450 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AOD59_22460 ENOG4105C02 permease AOD59_22475 ENOG41060CR AOD59_22480 ENOG4105C7H Helicase, RecD TraA family AOD59_22490 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AOD59_22495 ENOG4105C3J Cysteine desulfurase AOD59_22505 ENOG4105D1H recombination factor protein RarA AOD59_22510 ENOG4108VCI transcription factor, rsfa family AOD59_22515 ENOG4105CUZ uba thif-type nad fad binding protein AOD59_22525 ENOG4105CUT histidyl-tRNA synthetase AOD59_22540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AOD59_22550 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AOD59_22555 ENOG41076HS cation diffusion facilitator family transporter AOD59_22560 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AOD59_22570 ENOG4105CKP Polysaccharide Biosynthesis Protein AOD59_22575 ENOG4108QG2 Membrane AOD59_22585 ENOG4105VIE preprotein translocase, subunit YajC AOD59_22600 ENOG41061AI Protein of unknown function (DUF2905) AOD59_22615 ENOG4108HUF Transporter AOD59_22625 ENOG4108IPJ Membrane AOD59_22630 ENOG4108IPJ Membrane AOD59_22635 ENOG41082BM Transcriptional regulator, arsr family AOD59_22660 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AOD59_22665 ENOG4108IYU L-aspartate oxidase AOD59_22680 ENOG4108RPX mosc domain containing protein AOD59_22685 ENOG4105CQC Prephenate dehydratase AOD59_22705 ENOG4105EWM Histidine kinase AOD59_22720 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AOD59_22735 ENOG4105X36 (ribosomal) protein AOD59_22745 ENOG4105C03 ribonuclease AOD59_22760 ENOG4107QMS site-determining protein AOD59_22775 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AOD59_22780 ENOG4105DFF Rod shape-determining protein mreb AOD59_22800 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AOD59_22805 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AOD59_22815 ENOG41068KH stage VI sporulation protein D AOD59_22825 ENOG4105D52 delta-aminolevulinic acid dehydratase AOD59_22850 ENOG4105K56 Transcriptional regulator AOD59_22870 ENOG4108IUQ atp-dependent protease AOD59_22900 ENOG4108QCI YvbH-like oligomerisation region AOD59_22920 ENOG4105M59 Phosphodiesterase, mj0936 family AOD59_22925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AOD59_22935 ENOG4108XJQ germination protein AOD59_22945 ENOG4108PCX Major Facilitator AOD59_22955 ENOG4105KBX Transcriptional regulator, TetR family AOD59_22970 ENOG4105PFC Transcriptional regulator AOD59_22985 ENOG4105DZC cytosine deaminase AOD59_22990 ENOG4105DZC cytosine deaminase AOD59_22995 ENOG4105DEF Extracellular solute-binding protein, family 5 AOD59_23000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AOD59_23015 ENOG4108JQ7 (ABC) transporter AOD59_23020 ENOG4108HRK Histidine kinase AOD59_23025 ENOG4105DY9 regulatoR AOD59_23040 ENOG41067S9 phage shock protein C, PspC AOD59_23045 ENOG4108JCI Transcriptional regulator AOD59_23055 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AOD59_23060 ENOG4108Z40 Transcriptional regulator AOD59_23065 ENOG4105RHA ABC transporter, permease AOD59_23070 ENOG4108IUX (ABC) transporter AOD59_23075 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AOD59_23085 ENOG4105E14 MotA TolQ exbB proton channel AOD59_23090 ENOG4108VXD carboxy-peptidase AOD59_23100 ENOG4105E33 succinate dehydrogenase AOD59_23110 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AOD59_23125 ENOG4105K63 Thioredoxin AOD59_23130 ENOG4105C10 Electron transfer flavoprotein AOD59_23135 ENOG4105BZJ Electron transfer flavoprotein AOD59_23140 ENOG41060WC Enoyl-CoA hydratase AOD59_23145 ENOG4107Z3H Transcriptional regulator, TetR family AOD59_23150 ENOG4105CEY Amp-dependent synthetase and ligase AOD59_23160 ENOG4105J76 Periplasmic binding protein AOD59_23165 ENOG4105S6R Iron-hydroxamate transporter permease subunit AOD59_23210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_23225 ENOG4105DR4 Methyltransferase AOD59_23240 ENOG4105KFN sortase, SrtB family AOD59_23245 ENOG4105E0A ABC, transporter AOD59_23260 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AOD59_23270 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AOD59_23280 ENOG4105FE9 pseudouridine synthase AOD59_23295 ENOG4105DCG PHP domain protein AOD59_23330 ENOG4105C5S asparaginyl-tRNA synthetase AOD59_23335 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AOD59_23345 ENOG4108RWN rrna methyltransferase AOD59_23380 ENOG4105C0R drug resistance transporter emrb qaca subfamily AOD59_23385 ENOG4105CW7 secretion protein, HlyD family AOD59_23390 ENOG4108JGH Tetr family transcriptional regulator AOD59_23395 ENOG4105CN9 Peptidase m42 family protein AOD59_23415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AOD59_23420 ENOG4105C22 threonyL-tRNA synthetase AOD59_23425 ENOG4108TDW sporulation protein YtxC AOD59_23445 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD59_23450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AOD59_23455 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AOD59_23465 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AOD59_23470 ENOG4105C2M dna polymerase I AOD59_23475 ENOG4105BZU Histidine kinase AOD59_23480 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_23500 ENOG4108HMX isocitrate dehydrogenase (NADP) AOD59_23505 ENOG4105BZN citrate synthase AOD59_23520 ENOG4108REF Sporulation integral membrane protein ytvi AOD59_23525 ENOG4105FS0 cytoplasmic membrane protein AOD59_23550 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AOD59_23555 ENOG4105C6K Malic enzyme AOD59_23560 ENOG4105C0B DNA polymerase III (alpha subunit) AOD59_23565 ENOG4105VV2 AOD59_23575 ENOG4105SFS phosphoesterase RecJ domain protein AOD59_23610 ENOG4105DC7 peptidase M24 AOD59_23645 ENOG4105Z7P Acetyltransferase (GNAT) family AOD59_23650 ENOG41082W1 Cupin 2, conserved barrel domain protein AOD59_23660 ENOG4105VZ8 Transcriptional regulator AOD59_23680 ENOG4107YZX Universal stress protein AOD59_23720 ENOG4108JYZ YitT family AOD59_23740 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AOD59_23750 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AOD59_23755 ENOG4105KBJ sporulation protein ytfj AOD59_23770 ENOG4105EFZ amidohydrolase AOD59_23780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AOD59_23805 ENOG4106KR7 LysR family Transcriptional regulator AOD59_23825 ENOG4105C28 cystathionine AOD59_23845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD59_23855 ENOG4105EMN RNA polymerase sigma factor AOD59_23870 ENOG4105F1V Acetoin utilization protein AOD59_23875 ENOG4105W87 Cbs domain AOD59_23880 ENOG4105DGU Histone deacetylase AOD59_23890 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AOD59_23900 ENOG4107SNB ankyrin repeat protein YahD AOD59_23905 ENOG4105EP9 oxidoreductase AOD59_23935 ENOG4105ETE Transcriptional regulator (LacI family AOD59_23960 ENOG4105C88 aminopeptidase AOD59_24005 ENOG4108VDD TRNA binding domain protein AOD59_24035 ENOG4105C8F Beta-lactamase domain protein AOD59_24050 ENOG4108V15 phosphotransferase enzyme family AOD59_24055 ENOG4108IUM Glycogen debranching enzyme AOD59_24070 ENOG4107QSE Dipeptidase AOD59_24075 ENOG4107QSE Dipeptidase AOD59_24080 ENOG4105YW5 deoR family transcriptional regulator AOD59_24095 ENOG4105CBX hi0933 family AOD59_24130 ENOG4108VJ1 Transcriptional regulator (CarD family AOD59_24135 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AOD59_24140 ENOG4105CSC Glucose uptake protein AOD59_24155 ENOG4108ZAF Molybdopterin AOD59_24160 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AOD59_24165 ENOG4105CVM Molybdenum cofactor synthesis domain protein AOD59_24175 ENOG4105D06 uba thif-type nad fad binding protein AOD59_24200 ENOG41085GJ domain protein AOD59_24210 ENOG4105DWV Homoserine O-trans-acetylase AOD59_24220 ENOG4108B31 Spore germination protein AOD59_24255 ENOG410605W Major Facilitator AOD59_24260 ENOG4107S91 Sodium hydrogen exchanger AOD59_24265 ENOG4105NCW Trka-c domain protein AOD59_24280 ENOG4105C19 ABC transporter AOD59_24300 ENOG4105N5T Radical SAM Protein AOD59_24310 ENOG4105DA5 (ABC) transporter AOD59_24340 ENOG4105E8V Alpha Beta Hydrolase Fold protein AOD59_24345 ENOG4108Z0R Transferase AOD59_24350 ENOG4105YVM Phosphoesterase, PA-phosphatase related AOD59_24355 ENOG4105BZF Glycosyl transferase (Group 1 AOD59_24365 ENOG4108RIR Molybdenum cofactor biosynthesis protein AOD59_24420 ENOG4105EGD dinuclear metal center protein, YbgI family AOD59_24425 ENOG4105BZU Histidine kinase AOD59_24430 ENOG4105BZU Histidine kinase AOD59_24435 ENOG4107S9D Alpha beta hydrolase AOD59_24455 ENOG4105D2X ABC transporter substrate-binding protein AOD59_24465 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AOD59_24520 ENOG4108V2W Carbonate dehydratase AOD59_24525 ENOG4105C4M (Ubiquinol oxidase) subunit I AOD59_24530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AOD59_24575 ENOG41087YS Phage shock protein A AOD59_24610 ENOG4105BZU Histidine kinase AOD59_24615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_24640 ENOG4108UGV hypoxanthine phosphoribosyltransferase AOD59_24645 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AOD59_24680 ENOG4107ZTW SNARE associated Golgi AOD59_24695 ENOG4105C19 ABC transporter AOD59_24700 ENOG41086D8 Transcriptional regulator AOD59_24750 ENOG4105C6Z Gluconate AOD59_24755 ENOG4105FDP GntR family transcriptional regulator AOD59_24775 ENOG41069H0 dihydroorotase EC 3.5.2.3 AOD59_24805 ENOG4105DTQ mandelate racemase muconate lactonizing AOD59_24815 ENOG4108IPT Naphthoate synthase AOD59_24820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AOD59_24825 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AOD59_24830 ENOG4105E4F Isochorismate synthase AOD59_24835 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AOD59_24845 ENOG4105VEQ Cold shock protein AOD59_24870 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AOD59_24880 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AOD59_24890 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD59_24985 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AOD59_25020 ENOG4105KT7 mgtC SapB transporter AOD59_25025 ENOG4107PBV potassium channel AOD59_25035 ENOG4107QYV phosphohexose isomerase AOD59_25045 ENOG4105WG9 Conserved Protein AOD59_25055 ENOG4105CHM Aminotransferase AOD59_25060 ENOG4108ZB6 transcriptional regulator AsnC family AOD59_25065 ENOG4105C5I Dehydrogenase AOD59_25070 ENOG4108MUZ hydrolase AOD59_25080 ENOG4105C87 Aminotransferase class I and II AOD59_25095 ENOG4105Y38 Kinase-associated protein B AOD59_25105 ENOG4107R3E Citrate transporter AOD59_25120 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AOD59_25125 ENOG4105KA0 thioesterase Superfamily protein AOD59_25145 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AOD59_25165 ENOG41069ER domain protein AOD59_25180 ENOG4105CEP NADH dehydrogenase AOD59_25210 ENOG4105EWC Purine nucleoside phosphorylase AOD59_25230 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AOD59_25255 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AOD59_25260 ENOG4105C4B ABC transporter, permease AOD59_25265 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AOD59_25310 ENOG41083MR nifu domain-containing protein AOD59_25325 ENOG4108W5N phosphatidylglycerophosphatase a AOD59_25340 ENOG4105DYS nad(p)h dehydrogenase (quinone) AOD59_25345 ENOG4105D4U had-superfamily hydrolase, subfamily iia AOD59_25360 ENOG4105CBT Fructose-1,6-bisphosphatase AOD59_25380 ENOG4105MMD transcriptional regulator AOD59_25385 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AOD59_25390 ENOG4107TXC Transcriptional regulator AOD59_25395 ENOG41090T1 Membrane AOD59_25420 ENOG4105FAA peptidase M23 AOD59_25430 ENOG4105KZD Domain of unknown function (DUF1805) AOD59_25435 ENOG4107R8B 5'-nucleotidase AOD59_25460 ENOG4105DIW FeS assembly protein SUFB AOD59_25465 ENOG4108UNV SUF system FeS assembly protein, NifU family AOD59_25470 ENOG4105C9B Cysteine desulfurase AOD59_25475 ENOG4105JRK feS assembly protein SufD AOD59_25480 ENOG4105C3K feS assembly ATPase SufC AOD59_25485 ENOG4105D01 (LipO)protein AOD59_25490 ENOG4105D01 (LipO)protein AOD59_25495 ENOG4108UMI ABC transporter, permease AOD59_25530 ENOG41080E8 Transcriptional regulator, Spx MgsR family AOD59_25580 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AOD59_25605 ENOG4108W8B Beta-lactamase domain protein AOD59_25610 ENOG4105C1G acyl-Coa dehydrogenase AOD59_25620 ENOG4105CHU acetyl-coa acetyltransferase AOD59_25635 ENOG4105DZ1 carboxypeptidase AOD59_25655 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AOD59_25675 ENOG4108SUT Major Facilitator Superfamily AOD59_25680 ENOG4107R7I amino acid AOD59_25690 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AOD59_25700 ENOG4107AYK membrAne AOD59_25735 ENOG4107ZTW SNARE associated Golgi AOD59_25745 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AOD59_25750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_25755 ENOG4105BZU Histidine kinase AOD59_25765 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AOD59_25780 ENOG4105VG1 fes assembly suf system protein AOD59_25785 ENOG4105D4Y metalloprotease AOD59_25805 ENOG4107S91 Sodium hydrogen exchanger AOD59_25810 ENOG4105NCW Trka-c domain protein AOD59_25825 ENOG4108RMU ferritin dps family protein AOD59_25840 ENOG4108URH decarboxylase AOD59_25865 ENOG4105D9N nucleoside AOD59_25870 ENOG4105D9N nucleoside AOD59_25885 ENOG4108RYK Nad-dependent epimerase dehydratase AOD59_25900 ENOG4105CV8 reductase AOD59_25905 ENOG4105F27 Major Facilitator AOD59_25910 ENOG4105KVH Transcriptional regulator AOD59_25925 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AOD59_25930 ENOG4105D4A Cell wall formation (By similarity) AOD59_25940 ENOG4105C8Q Methyl-accepting chemotaxis AOD59_25950 ENOG4105WMR Protein CrcB homolog AOD59_25955 ENOG4105WMR Protein CrcB homolog AOD59_25970 ENOG4108MK9 spermidine N(1)-acetyltransferase AOD59_25975 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AOD59_25990 ENOG4108IPW abc transporter atp-binding protein AOD59_25995 ENOG4105CM4 permease protein AOD59_26020 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AOD59_26030 ENOG4105XZU Preprotein translocase, subunit SecG AOD59_26035 ENOG41067MG lrgb family AOD59_26135 ENOG4105EFC phage portal protein HK97 family AOD59_26160 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AOD59_26170 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AOD59_26175 ENOG4105CP7 Triose-phosphate isomerase AOD59_26200 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_26220 ENOG41090VF Stage v sporulation protein ac AOD59_26225 ENOG4105CZ3 stage V sporulation protein ad AOD59_26240 ENOG4105H67 Protein of unknown function (DUF421) AOD59_26245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AOD59_26250 ENOG4105KRI phosphocarrier protein (HPr AOD59_26260 ENOG4105CHW UPF0052 protein AOD59_26270 ENOG4108Z4K mutator MutT protein AOD59_26280 ENOG4105C3M thioredoxin reductase AOD59_26290 ENOG4108S4C acetyltransferase AOD59_26310 ENOG41086DT Membrane protein of unknown function AOD59_26320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AOD59_26325 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AOD59_26330 ENOG4105D7V transposase AOD59_26345 ENOG4107TXC Transcriptional regulator AOD59_26370 ENOG4105HMI Membrane AOD59_26375 ENOG4105DUM transcriptional regulator, lysR family AOD59_26385 ENOG4108WS4 fmn reductase AOD59_26400 ENOG4105BZ1 (ABC) transporter AOD59_26410 ENOG4105CN1 protease AOD59_26415 ENOG4105CRP Part of the ABC transporter FtsEX involved in AOD59_26420 ENOG4105CAK Cell division ATP-binding protein ftsE AOD59_26435 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AOD59_26440 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AOD59_26445 ENOG4105MS2 ribosomal subunit Interface protein AOD59_26450 ENOG4105VEQ Cold shock protein AOD59_26455 ENOG41081UC Inherit from COG: Competence protein AOD59_26470 ENOG4105KVH Transcriptional regulator AOD59_26485 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AOD59_26490 ENOG4108KGH TRANSCRIPTIONal AOD59_26495 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD59_26500 ENOG4105C6Y Udp-glucose 6-dehydrogenase AOD59_26505 ENOG4105ESV Glycosyl transferase, family 4 AOD59_26515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AOD59_26530 ENOG410901P UPF0249 protein AOD59_26535 ENOG4105F8D glycoside hydrolase family 4 AOD59_26540 ENOG4105VCP PTS System AOD59_26545 ENOG4105CK1 PTS System AOD59_26555 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AOD59_26560 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AOD59_26565 ENOG4105VCP PTS System AOD59_26575 ENOG4105VZJ PTS System AOD59_26590 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AOD59_26595 ENOG4105ECB domain protein AOD59_26600 ENOG4107RSM transcriptional regulator AOD59_26645 ENOG4105DAA L-lactate AOD59_26655 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AOD59_26665 ENOG4105E0M Sulfatase AOD59_26700 ENOG4105C94 Transporter AOD59_26705 ENOG41069ER domain protein AOD59_26730 ENOG4105KBK Zinc finger, swim domain protein AOD59_26735 ENOG4105C0D helicase AOD59_26765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AOD59_26775 ENOG4107RBB ABC transporter, permease AOD59_26780 ENOG4105C19 ABC transporter AOD59_26800 ENOG4105CXY transporter AOD59_26815 ENOG4105BZU Histidine kinase AOD59_26820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_26825 ENOG4105CMR udp-glucose 4-epimerase AOD59_26840 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AOD59_26845 ENOG4105EY8 ABC transporter AOD59_26900 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AOD59_26915 ENOG4105FRN stage II sporulation protein AOD59_26930 ENOG4105DY9 regulatoR AOD59_26935 ENOG4108IUW ABC transporter AOD59_26955 ENOG4106778 Protein of unknown function (DUF1146) AOD59_26960 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD59_26965 ENOG4105C8S subunit m AOD59_26970 ENOG4105D65 subunit l AOD59_26995 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AOD59_27000 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD59_27010 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AOD59_27015 ENOG4105BZU Histidine kinase AOD59_27065 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AOD59_27070 ENOG41062M3 atp synthase AOD59_27100 ENOG4108YZG isomerase AOD59_27115 ENOG4108VGI doxx family AOD59_27120 ENOG4107XC4 flavin reductase domain protein, FMN-binding AOD59_27135 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AOD59_27145 ENOG4108ZXQ stage ii sporulation protein r AOD59_27150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AOD59_27155 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AOD59_27170 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AOD59_27175 ENOG4105CBT Fructose-1,6-bisphosphatase AOD59_27180 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AOD59_27215 ENOG4105C1G acyl-Coa dehydrogenase AOD59_27220 ENOG4105C1G acyl-Coa dehydrogenase AOD59_27225 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AOD59_27235 ENOG4105DF6 Fe-S oxidoreductase AOD59_27250 ENOG4105BZU Histidine kinase AOD59_27270 ENOG4105BZU Histidine kinase AOD59_27275 ENOG4105KCT ABC transporter AOD59_27280 ENOG4108M15 ABC transporter AOD59_27285 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AOD59_27305 ENOG4105IIU Aminopeptidase AOD59_27325 ENOG4105EMN RNA polymerase sigma factor AOD59_27335 ENOG410684U Domain of unknown function (DUF1934) AOD59_27360 ENOG4105CYW agmatinase AOD59_27370 ENOG4105DXB Major Facilitator superfamily AOD59_27375 ENOG4107SWG transcriptional regulator MERR family AOD59_27380 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AOD59_27385 ENOG4105BZ4 penicillin-binding protein AOD59_27390 ENOG4108XFG YwhD family AOD59_27395 ENOG4108Z4T Peptidase M50 AOD59_27400 ENOG41069HH 4-oxalocrotonate tautomerase AOD59_27405 ENOG4105DCI Phosphohydrolase AOD59_27410 ENOG4108MES Periplasmic binding protein AOD59_27415 ENOG4105E0A ABC, transporter AOD59_27420 ENOG4105EHG Permease protein AOD59_27425 ENOG4105DQ5 transport system permease protein AOD59_27430 ENOG4105DQ5 transport system permease protein AOD59_27440 ENOG4108VCI transcription factor, rsfa family AOD59_27455 ENOG4108IJ2 phosphate acetyltransferase AOD59_27470 ENOG4108VKI Cell wall hydrolase AOD59_27500 ENOG410667J hydrolase AOD59_27505 ENOG4105VCH membrane AOD59_27515 ENOG4108TU7 Inherit from COG: (ABC) transporter AOD59_27520 ENOG4105CJ1 ABC, transporter AOD59_27525 ENOG41090WU lipolytic protein G-D-S-L family AOD59_27540 ENOG4105D6E homoserine dehydrogenase AOD59_27565 ENOG4108Y4K DNA-binding transcriptional activator AOD59_27575 ENOG4105WH1 Two component transcriptional regulator luxr family AOD59_27585 ENOG4105DWF phosphomethylpyrimidine kinase AOD59_27590 ENOG4105BZU Histidine kinase AOD59_27595 ENOG4105VCD cytoplasmic protein AOD59_27600 ENOG4105D22 carbon starvation protein AOD59_27605 ENOG4105DY9 regulatoR AOD59_27610 ENOG41079KZ Major Facilitator Superfamily AOD59_27630 ENOG4105EN6 Membrane AOD59_27635 ENOG4106YBV Methyl-accepting chemotaxis AOD59_27645 ENOG4108S4H thioesterase Superfamily protein AOD59_27655 ENOG4105JEU Glycosyl transferase, family 2 AOD59_27660 ENOG4105C5H ABC transporter AOD59_27690 ENOG4105CKK Glycosyl transferase, family 2 AOD59_27695 ENOG41067SE Tetr family transcriptional regulator AOD59_27705 ENOG4105E0X reductase AOD59_27710 ENOG4106F5Q Membrane AOD59_27725 ENOG4105DY9 regulatoR AOD59_27730 ENOG4108HRK Histidine kinase AOD59_27735 ENOG4107RGD Major Facilitator superfamily AOD59_27750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AOD59_27760 ENOG4105IW1 AmiS UreI transporter AOD59_27770 ENOG4105CMR udp-glucose 4-epimerase AOD59_27775 ENOG4108UT2 hemolysin iii AOD59_27785 ENOG4105C1J atp-dependent rna helicase AOD59_27800 ENOG4105DPN Oligoendopeptidase f AOD59_27820 ENOG4105C0H protease AOD59_27825 ENOG4105Q2H domain protein AOD59_27840 ENOG4105BZU Histidine kinase AOD59_27845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AOD59_27875 ENOG4105CDU Replicative dna helicase AOD59_27885 ENOG4105BZR domain protein AOD59_27890 ENOG4108XMW Membrane AOD59_27900 ENOG4108UUM single-stranded DNA-binding protein AOD59_27910 ENOG4105C3G gtp-binding protein AOD59_27915 ENOG4105VDK protein, conserved in bacteria AOD59_27920 ENOG4105D8X mechanosensitive ion channel AOD59_27925 ENOG4108ZDA Sporulation protein YyaC AOD59_27930 ENOG4105FA0 parb-like partition protein AOD59_27935 ENOG4107QJE Chromosome Partitioning Protein AOD59_27955 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AOD59_27965 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins